locus-tag	class	description
AKO65_RS00020	COG0735	belongs to the Fur family
AKO65_RS00025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKO65_RS00030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKO65_RS00035	COG4129	membrane
AKO65_RS00040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO65_RS00045	COG0601	transmembrane transport
AKO65_RS00050	COG0747	negative chemotaxis
AKO65_RS00055	COG4608	Belongs to the ABC transporter superfamily
AKO65_RS00060	COG0444	Belongs to the ABC transporter superfamily
AKO65_RS00065	COG1132	(ABC) transporter
AKO65_RS00070	COG3557	Belongs to the UPF0374 family
AKO65_RS00085	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS00095	COG1194	a g-specific adenine glycosylase
AKO65_RS00100	COG1988	membrane-bound metal-dependent
AKO65_RS00110	COG1191	sigma factor activity
AKO65_RS00115	COG2140	Oxalate decarboxylase
AKO65_RS00130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKO65_RS00135	COG4485	Bacterial membrane protein, YfhO
AKO65_RS00140	COG0463	Glycosyl transferase, family 2
AKO65_RS00160	COG2137	regulation of response to DNA damage stimulus
AKO65_RS00165	COG1090	epimerase
AKO65_RS00175	COG0778	Nitroreductase
AKO65_RS00195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AKO65_RS00195	COG0392	lysyltransferase activity
AKO65_RS00200	COG1846	Transcriptional regulator
AKO65_RS00210	COG2318	DinB family
AKO65_RS00230	COG1595	DNA-templated transcription, initiation
AKO65_RS00235	COG1742	UPF0060 membrane protein
AKO65_RS00240	COG1132	(ABC) transporter
AKO65_RS00245	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AKO65_RS00250	COG2169	Transcriptional regulator
AKO65_RS00255	COG0492	ferredoxin-NADP+ reductase activity
AKO65_RS00260	COG2755	lipolytic protein G-D-S-L family
AKO65_RS00265	COG4637	Psort location Cytoplasmic, score
AKO65_RS00275	COG1309	transcriptional regulator
AKO65_RS00280	COG2076	Multidrug Resistance protein
AKO65_RS00285	COG2076	Multidrug Resistance protein
AKO65_RS00340	COG2814	Major facilitator Superfamily
AKO65_RS00345	COG0789	Transcriptional regulator
AKO65_RS00350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKO65_RS00355	COG1942	4-Oxalocrotonate Tautomerase
AKO65_RS00375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKO65_RS00380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AKO65_RS00390	COG0598	Magnesium transport protein CorA
AKO65_RS00400	COG0726	polysaccharide deacetylase
AKO65_RS00410	COG0535	radical SAM domain protein
AKO65_RS00415	COG0668	transmembrane transport
AKO65_RS00425	COG0217	transcriptional regulatory protein
AKO65_RS00435	COG0387	Pfam Sodium calcium exchanger
AKO65_RS00445	COG0477	Major facilitator Superfamily
AKO65_RS00450	COG1295	ribonuclease BN
AKO65_RS00455	COG4980	gas vesicle protein
AKO65_RS00460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO65_RS00465	COG1115	amino acid carrier protein
AKO65_RS00470	COG4840	Belongs to the UPF0435 family
AKO65_RS00475	COG0693	protein deglycase activity
AKO65_RS00480	COG0737	Belongs to the 5'-nucleotidase family
AKO65_RS00490	COG2188	Transcriptional regulator
AKO65_RS00495	COG0366	Alpha amylase catalytic
AKO65_RS00500	COG1263	PTS System
AKO65_RS00500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS00515	COG0076	glutamate decarboxylase activity
AKO65_RS00520	COG1368	sulfuric ester hydrolase activity
AKO65_RS00535	COG3739	integral membrane protein
AKO65_RS00540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS00540	COG1263	PTS System
AKO65_RS00545	COG0024	Methionine aminopeptidase
AKO65_RS00550	COG2258	MOSC domain
AKO65_RS00555	COG1254	Belongs to the acylphosphatase family
AKO65_RS00565	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AKO65_RS00570	COG1695	Transcriptional regulator
AKO65_RS00575	COG3479	Phenolic acid decarboxylase
AKO65_RS00585	COG2851	Citrate transporter
AKO65_RS00590	COG3181	Tripartite tricarboxylate transporter family receptor
AKO65_RS00595	COG4565	transcriptional regulatory protein
AKO65_RS00600	COG3290	protein histidine kinase activity
AKO65_RS00610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO65_RS00610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO65_RS00620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKO65_RS00625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO65_RS00625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO65_RS00645	COG2130	NADP-dependent
AKO65_RS00650	COG0513	Belongs to the DEAD box helicase family
AKO65_RS00655	COG0488	(ABC) transporter
AKO65_RS00660	COG2814	Major facilitator Superfamily
AKO65_RS00665	COG0789	Transcriptional regulator
AKO65_RS00670	COG1469	GTP cyclohydrolase I activity
AKO65_RS00675	COG0488	(ABC) transporter
AKO65_RS00680	COG0463	Glycosyl transferase, family 2
AKO65_RS00680	COG0457	Tetratricopeptide repeat
AKO65_RS00685	COG0531	amino acid
AKO65_RS00700	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO65_RS00715	COG0471	metal ion transport
AKO65_RS00725	COG2223	nitrite transmembrane transporter activity
AKO65_RS00730	COG1442	glycosyl transferase family 8
AKO65_RS00735	COG1216	Glycosyl transferase, family 2
AKO65_RS00740	COG1442	glycosyl transferase family 8
AKO65_RS00745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO65_RS00750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKO65_RS00775	COG2211	Major facilitator Superfamily
AKO65_RS00785	COG1486	melibiose metabolic process
AKO65_RS00800	COG0492	ferredoxin-NADP+ reductase activity
AKO65_RS00805	COG1959	2 iron, 2 sulfur cluster binding
AKO65_RS00820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKO65_RS00825	COG5444	nuclease activity
AKO65_RS00835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKO65_RS00840	COG1597	lipid kinase activity
AKO65_RS00845	COG1957	nucleoside hydrolase
AKO65_RS00850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKO65_RS00855	COG1309	transcriptional regulator
AKO65_RS00860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKO65_RS00865	COG0154	amidase activity
AKO65_RS00870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKO65_RS00875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO65_RS00880	COG1285	pathogenesis
AKO65_RS00885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO65_RS00890	COG4851	CamS sex pheromone cAM373 precursor
AKO65_RS00895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKO65_RS00900	COG0210	DNA helicase
AKO65_RS00905	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AKO65_RS00920	COG0069	glutamate synthase activity
AKO65_RS00930	COG4496	protein, YerC YecD
AKO65_RS00935	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKO65_RS00945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKO65_RS00950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKO65_RS00955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AKO65_RS00960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKO65_RS00980	COG0151	Belongs to the GarS family
AKO65_RS00985	COG0138	bifunctional purine biosynthesis protein purh
AKO65_RS00990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKO65_RS00995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKO65_RS01000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AKO65_RS01005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKO65_RS01010	COG0047	phosphoribosylformylglycinamidine synthase activity
AKO65_RS01015	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKO65_RS01020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKO65_RS01025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKO65_RS01030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AKO65_RS01035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AKO65_RS01045	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AKO65_RS01050	COG3064	Membrane
AKO65_RS01055	COG5583	Uncharacterized small protein (DUF2292)
AKO65_RS01060	COG2252	PERMEase
AKO65_RS01065	COG0583	DNA-binding transcription factor activity
AKO65_RS01070	COG2814	Major facilitator Superfamily
AKO65_RS01080	COG1595	DNA-templated transcription, initiation
AKO65_RS01100	COG3279	Response regulator of the LytR AlgR family
AKO65_RS01130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO65_RS01140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKO65_RS01150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKO65_RS01150	COG0519	Catalyzes the synthesis of GMP from XMP
AKO65_RS01155	COG1305	Transglutaminase-like
AKO65_RS01160	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AKO65_RS01165	COG0714	Associated with various cellular activities
AKO65_RS01170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKO65_RS01175	COG1113	amino acid transport
AKO65_RS01180	COG2132	Multicopper oxidase
AKO65_RS01190	COG0823	Involved in the tonB-independent uptake of proteins
AKO65_RS01195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKO65_RS01220	COG1876	peptidase activity
AKO65_RS01225	COG2808	Putative FMN-binding domain
AKO65_RS01230	COG1846	Transcriptional regulator
AKO65_RS01255	COG0459	protein refolding
AKO65_RS01260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKO65_RS01265	COG1266	CAAX protease self-immunity
AKO65_RS01280	COG0805	protein transport
AKO65_RS01285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKO65_RS01290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AKO65_RS01295	COG0315	cyclic pyranopterin monophosphate synthase activity
AKO65_RS01300	COG0488	(ABC) transporter
AKO65_RS01305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKO65_RS01310	COG0456	acetyltransferase
AKO65_RS01315	COG1214	PFAM Peptidase M22, glycoprotease
AKO65_RS01320	COG0802	atpase or kinase
AKO65_RS01325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AKO65_RS01375	COG1301	dicarboxylic acid transport
AKO65_RS01385	COG0697	spore germination
AKO65_RS01390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKO65_RS01400	COG4122	O-methyltransferase activity
AKO65_RS01410	COG0456	acetyltransferase
AKO65_RS01420	COG1396	sequence-specific DNA binding
AKO65_RS01435	COG0778	Nitroreductase
AKO65_RS01440	COG1846	Transcriptional regulator
AKO65_RS01445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AKO65_RS01450	COG1309	transcriptional regulator
AKO65_RS01495	COG2814	Major facilitator Superfamily
AKO65_RS01515	COG2267	carboxylic ester hydrolase activity
AKO65_RS01520	COG0252	asparaginase activity
AKO65_RS01530	COG4221	oxidoreductase activity
AKO65_RS01540	COG0657	acetylesterase activity
AKO65_RS01545	COG0477	Major facilitator Superfamily
AKO65_RS01560	COG0789	Transcriptional regulator
AKO65_RS01565	COG1064	alcohol dehydrogenase
AKO65_RS01570	COG1329	Transcriptional regulator
AKO65_RS01575	COG1278	Cold shock
AKO65_RS01580	COG1404	Belongs to the peptidase S8 family
AKO65_RS01590	COG0433	COG0433 Predicted ATPase
AKO65_RS01630	COG3091	SprT-like family
AKO65_RS01635	COG2183	response to ionizing radiation
AKO65_RS01640	COG2208	phosphoserine phosphatase activity
AKO65_RS01645	COG1191	sigma factor activity
AKO65_RS01650	COG2172	sigma factor antagonist activity
AKO65_RS01655	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_RS01660	COG2208	phosphoserine phosphatase activity
AKO65_RS01665	COG2172	sigma factor antagonist activity
AKO65_RS01670	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_RS01675	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_RS01680	COG2337	Toxic component of a toxin-antitoxin (TA) module
AKO65_RS01685	COG0864	Transcriptional regulator
AKO65_RS01690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKO65_RS01695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AKO65_RS01700	COG0736	holo-[acyl-carrier-protein] synthase activity
AKO65_RS01705	COG0705	Rhomboid family
AKO65_RS01710	COG3428	Bacterial PH domain
AKO65_RS01715	COG3402	PFAM membrane-flanked domain
AKO65_RS01720	COG0513	Belongs to the DEAD box helicase family
AKO65_RS01735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKO65_RS01740	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKO65_RS01745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_RS01760	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AKO65_RS01765	COG1131	(ABC) transporter
AKO65_RS01770	COG1301	dicarboxylic acid transport
AKO65_RS01775	COG0628	permease
AKO65_RS01780	COG1301	dicarboxylic acid transport
AKO65_RS01785	COG4565	transcriptional regulatory protein
AKO65_RS01790	COG3290	protein histidine kinase activity
AKO65_RS01795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKO65_RS01800	COG2217	Heavy metal translocating P-type atpase
AKO65_RS01805	COG2261	transglycosylase associated protein
AKO65_RS01810	COG1914	H( )-stimulated, divalent metal cation uptake system
AKO65_RS01815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO65_RS01835	COG5444	nuclease activity
AKO65_RS01840	COG0028	Belongs to the TPP enzyme family
AKO65_RS01845	COG0531	amino acid
AKO65_RS01855	COG1215	transferase activity, transferring glycosyl groups
AKO65_RS01860	COG5298	Protein conserved in bacteria
AKO65_RS01865	COG3706	GGDEF domain
AKO65_RS01870	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AKO65_RS01875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKO65_RS01875	COG0551	DNA topoisomerase type I activity
AKO65_RS01880	COG2814	Major facilitator Superfamily
AKO65_RS01900	COG3871	stress protein (general stress protein 26)
AKO65_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS01910	COG2226	methyltransferase
AKO65_RS01915	COG3711	transcriptional antiterminator
AKO65_RS01925	COG2755	lipolytic protein G-D-S-L family
AKO65_RS01930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKO65_RS01935	COG1414	Transcriptional regulator
AKO65_RS01940	COG1984	allophanate hydrolase subunit 2
AKO65_RS01945	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AKO65_RS01950	COG4336	lyase activity
AKO65_RS01955	COG1914	H( )-stimulated, divalent metal cation uptake system
AKO65_RS01960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AKO65_RS01965	COG0457	Tetratricopeptide repeat
AKO65_RS01980	COG0561	phosphatase activity
AKO65_RS01990	COG0346	lactoylglutathione lyase activity
AKO65_RS02025	COG0840	transmembrane signaling receptor activity
AKO65_RS02030	COG0246	Mannitol dehydrogenase
AKO65_RS02035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS02040	COG2213	PTS system mannitol-specific
AKO65_RS02045	COG1276	copper resistance
AKO65_RS02045	COG2372	response to copper ion
AKO65_RS02050	COG4549	nuclear export factor GLE1
AKO65_RS02055	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKO65_RS02060	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_RS02065	COG0531	amino acid
AKO65_RS02070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AKO65_RS02075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_RS02080	COG0583	DNA-binding transcription factor activity
AKO65_RS02090	COG0640	Transcriptional regulator
AKO65_RS02100	COG1309	transcriptional regulator
AKO65_RS02105	COG2814	Major facilitator Superfamily
AKO65_RS02110	COG0527	aspartate kinase activity
AKO65_RS02115	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_RS02120	COG5002	protein histidine kinase activity
AKO65_RS02120	COG3850	Histidine kinase
AKO65_RS02125	COG0745	RESPONSE REGULATOR receiver
AKO65_RS02140	COG2079	MmgE PrpD family protein
AKO65_RS02145	COG1473	amidohydrolase
AKO65_RS02150	COG1126	abc transporter atp-binding protein
AKO65_RS02155	COG0765	amino acid transport
AKO65_RS02160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_RS02165	COG0456	acetyltransferase
AKO65_RS02170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO65_RS02175	COG5434	Belongs to the glycosyl hydrolase 28 family
AKO65_RS02180	COG3104	oligopeptide transport
AKO65_RS02185	COG0833	amino acid
AKO65_RS02190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_RS02195	COG0765	amino acid transport
AKO65_RS02200	COG1126	abc transporter atp-binding protein
AKO65_RS02205	COG2364	Membrane
AKO65_RS02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_RS02220	COG0697	spore germination
AKO65_RS02225	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AKO65_RS02240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO65_RS02245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO65_RS02250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO65_RS02260	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKO65_RS02265	COG3842	ATPase activity
AKO65_RS02290	COG3209	COG3209 Rhs family protein
AKO65_RS02295	COG3290	protein histidine kinase activity
AKO65_RS02295	COG0840	transmembrane signaling receptor activity
AKO65_RS02305	COG2746	aminoglycoside 3-N-acetyltransferase activity
AKO65_RS02310	COG1522	sequence-specific DNA binding
AKO65_RS02315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKO65_RS02325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_RS02330	COG0765	amino acid transport
AKO65_RS02335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKO65_RS02340	COG2508	Transcriptional regulator
AKO65_RS02345	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_RS02350	COG0506	proline dehydrogenase activity
AKO65_RS02355	COG3541	Predicted nucleotidyltransferase
AKO65_RS02365	COG3458	cephalosporin-C deacetylase activity
AKO65_RS02370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKO65_RS02375	COG0583	DNA-binding transcription factor activity
AKO65_RS02380	COG2226	methyltransferase
AKO65_RS02385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKO65_RS02400	COG2271	Major facilitator Superfamily
AKO65_RS02405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKO65_RS02415	COG0028	Belongs to the TPP enzyme family
AKO65_RS02420	COG0710	3-dehydroquinate dehydratase activity
AKO65_RS02425	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_RS02435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKO65_RS02440	COG3665	Urea carboxylase-associated protein
AKO65_RS02445	COG1113	amino acid transport
AKO65_RS02450	COG3403	YqcI/YcgG family
AKO65_RS02465	COG1280	lysine exporter protein (LysE YggA)
AKO65_RS02470	COG0738	Major facilitator superfamily
AKO65_RS02475	COG0673	inositol 2-dehydrogenase activity
AKO65_RS02480	COG0561	phosphatase activity
AKO65_RS02485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO65_RS02490	COG1609	Transcriptional regulator
AKO65_RS02495	COG1620	l-lactate permease
AKO65_RS02500	COG0039	L-malate dehydrogenase activity
AKO65_RS02505	COG1288	antiporter activity
AKO65_RS02510	COG1473	amidohydrolase
AKO65_RS02525	COG2113	Glycine betaine
AKO65_RS02530	COG4176	ABC-type proline glycine betaine transport system permease component
AKO65_RS02535	COG0517	IMP dehydrogenase activity
AKO65_RS02535	COG4175	Glycine betaine
AKO65_RS02540	COG3853	Toxic anion resistance protein (TelA)
AKO65_RS02570	COG0861	Integral membrane protein TerC family
AKO65_RS02575	COG2310	stress, protein
AKO65_RS02580	COG2310	stress, protein
AKO65_RS02585	COG2310	stress, protein
AKO65_RS02590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO65_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS02605	COG3773	Cell wall hydrolase
AKO65_RS02620	COG1668	transmembrane transport
AKO65_RS02625	COG4555	ABC transporter
AKO65_RS02630	COG3279	Response regulator of the LytR AlgR family
AKO65_RS02635	COG3290	protein histidine kinase activity
AKO65_RS02640	COG0667	Aldo Keto reductase
AKO65_RS02650	COG4585	Histidine kinase
AKO65_RS02655	COG2197	response regulator
AKO65_RS02665	COG3012	SEC-C Motif Domain Protein
AKO65_RS02665	COG1405	negative regulation of cell septum assembly
AKO65_RS02670	COG0784	Response regulator, receiver
AKO65_RS02675	COG4191	Histidine kinase
AKO65_RS02680	COG2066	Belongs to the glutaminase family
AKO65_RS02685	COG1115	amino acid carrier protein
AKO65_RS02690	COG0596	Alpha beta hydrolase
AKO65_RS02700	COG0531	amino acid
AKO65_RS02705	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_RS02710	COG1846	Transcriptional regulator
AKO65_RS02715	COG1063	alcohol dehydrogenase
AKO65_RS02720	COG1917	Cupin 2, conserved barrel domain protein
AKO65_RS02725	COG1309	transcriptional regulator
AKO65_RS02735	COG1404	Belongs to the peptidase S8 family
AKO65_RS02750	COG0456	acetyltransferase
AKO65_RS02755	COG2814	Major facilitator Superfamily
AKO65_RS02765	COG1695	Transcriptional regulator
AKO65_RS02770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_RS02775	COG2040	homocysteine
AKO65_RS02780	COG0833	amino acid
AKO65_RS02790	COG1404	Belongs to the peptidase S8 family
AKO65_RS02800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_RS02805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_RS02810	COG0383	alpha-mannosidase activity
AKO65_RS02815	COG1940	carbohydrate kinase activity
AKO65_RS02820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS02820	COG3711	transcriptional antiterminator
AKO65_RS02835	COG2723	6-phospho-beta-galactosidase activity
AKO65_RS02840	COG2190	(PTS) system
AKO65_RS02840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS02840	COG1263	PTS System
AKO65_RS02845	COG3711	transcriptional antiterminator
AKO65_RS02855	COG0531	amino acid
AKO65_RS02860	COG1054	Belongs to the UPF0176 family
AKO65_RS02865	COG0371	Dehydrogenase
AKO65_RS02870	COG0656	L-ascorbic acid biosynthetic process
AKO65_RS02880	COG1683	Conserved Protein
AKO65_RS02890	COG1846	Transcriptional regulator
AKO65_RS02905	COG2814	Major facilitator Superfamily
AKO65_RS02910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKO65_RS02915	COG0730	response to heat
AKO65_RS02920	COG0425	Belongs to the sulfur carrier protein TusA family
AKO65_RS02925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_RS02925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO65_RS02930	COG0425	Belongs to the sulfur carrier protein TusA family
AKO65_RS02930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO65_RS02940	COG2210	Belongs to the sulfur carrier protein TusA family
AKO65_RS02945	COG1937	Protein conserved in bacteria
AKO65_RS02960	COG0640	Transcriptional regulator
AKO65_RS02970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKO65_RS02975	COG1331	Highly conserved protein containing a thioredoxin domain
AKO65_RS02985	COG2271	Major facilitator Superfamily
AKO65_RS02990	COG0584	glycerophosphoryl diester phosphodiesterase
AKO65_RS02995	COG1113	amino acid transport
AKO65_RS03010	COG1309	transcriptional regulator
AKO65_RS03015	COG2207	Transcriptional regulator
AKO65_RS03020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKO65_RS03030	COG1476	TRANSCRIPTIONal
AKO65_RS03050	COG2311	Membrane
AKO65_RS03060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_RS03065	COG1413	lyase activity
AKO65_RS03075	COG1131	(ABC) transporter
AKO65_RS03080	COG1266	CAAX protease self-immunity
AKO65_RS03085	COG0535	radical SAM domain protein
AKO65_RS03100	COG1695	Transcriptional regulator
AKO65_RS03110	COG1136	(ABC) transporter
AKO65_RS03120	COG1131	(ABC) transporter
AKO65_RS03140	COG3852	Histidine kinase
AKO65_RS03145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKO65_RS03150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKO65_RS03155	COG4856	YbbR-like protein
AKO65_RS03160	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKO65_RS03165	COG5662	AntiSigma factor
AKO65_RS03170	COG1595	DNA-templated transcription, initiation
AKO65_RS03205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AKO65_RS03210	COG1737	Transcriptional regulator
AKO65_RS03215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS03215	COG1263	PTS System
AKO65_RS03220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AKO65_RS03225	COG1472	Belongs to the glycosyl hydrolase 3 family
AKO65_RS03230	COG3876	Protein conserved in bacteria
AKO65_RS03235	COG0385	Bile acid
AKO65_RS03240	COG0659	secondary active sulfate transmembrane transporter activity
AKO65_RS03245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_RS03285	COG0726	polysaccharide deacetylase
AKO65_RS03290	COG2194	sulfuric ester hydrolase activity
AKO65_RS03300	COG0489	protein tyrosine kinase activity
AKO65_RS03305	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_RS03330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO65_RS03335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKO65_RS03340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKO65_RS03345	COG0101	tRNA pseudouridine synthase activity
AKO65_RS03350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO65_RS03355	COG1122	ATPase activity
AKO65_RS03360	COG1122	ATPase activity
AKO65_RS03365	COG0203	ribosomal protein L17
AKO65_RS03370	COG0202	RNA polymerase activity
AKO65_RS03375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKO65_RS03380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKO65_RS03385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKO65_RS03390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKO65_RS03395	COG0024	Methionine aminopeptidase
AKO65_RS03400	COG0563	adenylate kinase activity
AKO65_RS03405	COG0201	protein transport
AKO65_RS03410	COG0200	Binds to the 23S rRNA
AKO65_RS03415	COG1841	ribosomal large subunit assembly
AKO65_RS03420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKO65_RS03425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKO65_RS03430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKO65_RS03435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKO65_RS03440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKO65_RS03445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKO65_RS03450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKO65_RS03455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKO65_RS03460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKO65_RS03465	COG0255	Belongs to the universal ribosomal protein uL29 family
AKO65_RS03470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKO65_RS03475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKO65_RS03480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKO65_RS03485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKO65_RS03490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKO65_RS03495	COG0089	rRNA binding
AKO65_RS03500	COG0088	Forms part of the polypeptide exit tunnel
AKO65_RS03505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKO65_RS03515	COG0596	Alpha beta hydrolase
AKO65_RS03520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKO65_RS03525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKO65_RS03530	COG0049	tRNA binding
AKO65_RS03535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKO65_RS03540	COG1358	cellular component organization or biogenesis
AKO65_RS03545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKO65_RS03550	COG0085	RNA polymerase activity
AKO65_RS03555	COG2813	Specifically methylates the guanine in position
AKO65_RS03560	COG0222	ribosome binding
AKO65_RS03565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKO65_RS03570	COG0081	regulation of translation
AKO65_RS03580	COG0250	Participates in transcription elongation, termination and antitermination
AKO65_RS03585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKO65_RS03590	COG1595	DNA-templated transcription, initiation
AKO65_RS03595	COG3688	RNA-binding protein containing a PIN domain
AKO65_RS03600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKO65_RS03605	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AKO65_RS03610	COG0215	cysteine-tRNA ligase activity
AKO65_RS03615	COG1045	serine acetyltransferase
AKO65_RS03620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKO65_RS03625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKO65_RS03630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKO65_RS03635	COG4956	integral membrane protein (PIN domain superfamily)
AKO65_RS03640	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AKO65_RS03645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AKO65_RS03650	COG0542	response to heat
AKO65_RS03655	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AKO65_RS03660	COG3880	PFAM UvrB UvrC protein
AKO65_RS03665	COG4463	regulation of RNA biosynthetic process
AKO65_RS03695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKO65_RS03700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKO65_RS03705	COG1396	sequence-specific DNA binding
AKO65_RS03710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKO65_RS03715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKO65_RS03720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKO65_RS03725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO65_RS03730	COG0512	Glutamine amidotransferase of anthranilate synthase
AKO65_RS03735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKO65_RS03740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO65_RS03745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKO65_RS03750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKO65_RS03755	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKO65_RS03760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKO65_RS03765	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKO65_RS03770	COG0037	tRNA processing
AKO65_RS03775	COG0515	serine threonine protein kinase
AKO65_RS03780	COG2304	oxidoreductase activity
AKO65_RS03785	COG2208	phosphoserine phosphatase activity
AKO65_RS03800	COG1098	S1 RNA binding domain
AKO65_RS03805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AKO65_RS03820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKO65_RS03825	COG3956	TIGRFAM MazG family protein
AKO65_RS03830	COG2244	polysaccharide biosynthetic process
AKO65_RS03835	COG2002	toxin-antitoxin pair type II binding
AKO65_RS03840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKO65_RS03850	COG0193	aminoacyl-tRNA hydrolase activity
AKO65_RS03855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKO65_RS03860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKO65_RS03870	COG2088	sporulation resulting in formation of a cellular spore
AKO65_RS03875	COG0251	oxidation-reduction process
AKO65_RS03880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO65_RS03885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKO65_RS03895	COG4466	Protein conserved in bacteria
AKO65_RS03905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKO65_RS03910	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AKO65_RS03915	COG3584	3D domain protein
AKO65_RS03915	COG3583	domain protein
AKO65_RS03920	COG0084	hydrolase, TatD family'
AKO65_RS03925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_RS03925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_RS03930	COG2002	toxin-antitoxin pair type II binding
AKO65_RS03935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKO65_RS03940	COG2827	Endonuclease containing a URI domain
AKO65_RS03945	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKO65_RS03950	COG4467	Involved in initiation control of chromosome replication
AKO65_RS03955	COG1774	PSP1 C-terminal conserved region
AKO65_RS03960	COG0470	DNA polymerase III
AKO65_RS03965	COG1728	Protein conserved in bacteria
AKO65_RS03970	COG3870	Protein conserved in bacteria
AKO65_RS03975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKO65_RS03980	COG1982	Orn Lys Arg decarboxylase major
AKO65_RS03985	COG3853	Toxic anion resistance protein (TelA)
AKO65_RS03990	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
AKO65_RS04035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKO65_RS04040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKO65_RS04045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AKO65_RS04050	COG0590	tRNA wobble adenosine to inosine editing
AKO65_RS04055	COG1335	isochorismatase
AKO65_RS04060	COG1388	LysM domain
AKO65_RS04060	COG3858	chitin binding
AKO65_RS04065	COG1428	Deoxynucleoside kinase
AKO65_RS04070	COG1428	Deoxynucleoside kinase
AKO65_RS04080	COG0840	transmembrane signaling receptor activity
AKO65_RS04085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKO65_RS04090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AKO65_RS04095	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AKO65_RS04100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_RS04105	COG1686	Belongs to the peptidase S11 family
AKO65_RS04110	COG0517	IMP dehydrogenase activity
AKO65_RS04110	COG0516	GMP reductase activity
AKO65_RS04145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKO65_RS04150	COG0187	DNA topoisomerase II activity
AKO65_RS04160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKO65_RS04165	COG2501	S4 domain
AKO65_RS04170	COG0592	DNA-directed DNA polymerase activity
AKO65_RS04175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKO65_RS04180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKO65_RS04185	COG0594	ribonuclease P activity
AKO65_RS04190	COG0706	membrane insertase activity
AKO65_RS04195	COG1847	R3H domain protein
AKO65_RS04200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKO65_RS04205	COG0445	tRNA wobble uridine modification
AKO65_RS04210	COG0357	Ribosomal RNA small subunit methyltransferase G
AKO65_RS04215	COG1475	DNA binding
AKO65_RS04225	COG1192	Involved in chromosome partitioning
AKO65_RS04230	COG1475	DNA binding
AKO65_RS04240	COG3949	Membrane
AKO65_RS04255	COG4481	Protein conserved in bacteria
AKO65_RS04260	COG0012	GTP binding
AKO65_RS04265	COG0360	Binds together with S18 to 16S ribosomal RNA
AKO65_RS04270	COG0629	single-stranded DNA binding
AKO65_RS04275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKO65_RS04280	COG0517	IMP dehydrogenase activity
AKO65_RS04280	COG1125	glycine betaine transport
AKO65_RS04285	COG1174	glycine betaine transport
AKO65_RS04290	COG0346	lactoylglutathione lyase activity
AKO65_RS04295	COG0400	carboxylic ester hydrolase activity
AKO65_RS04300	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKO65_RS04305	COG0753	catalase activity
AKO65_RS04315	COG1595	DNA-templated transcription, initiation
AKO65_RS04325	COG1227	inorganic diphosphatase activity
AKO65_RS04330	COG4241	membrane
AKO65_RS04335	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AKO65_RS04340	COG0359	binds to the 23S rRNA
AKO65_RS04345	COG2807	transmembrane transport
AKO65_RS04350	COG2819	hydrolase of the alpha beta superfamily
AKO65_RS04355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_RS04360	COG2207	Transcriptional regulator
AKO65_RS04360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_RS04365	COG2819	hydrolase of the alpha beta superfamily
AKO65_RS04385	COG0305	Participates in initiation and elongation during chromosome replication
AKO65_RS04390	COG0346	lactoylglutathione lyase activity
AKO65_RS04395	COG2124	cytochrome p450
AKO65_RS04400	COG1309	transcriptional regulator
AKO65_RS04405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKO65_RS04410	COG2311	Membrane
AKO65_RS04420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKO65_RS04445	COG0745	RESPONSE REGULATOR receiver
AKO65_RS04450	COG5002	protein histidine kinase activity
AKO65_RS04455	COG4863	YycH protein
AKO65_RS04460	COG4853	Protein conserved in bacteria
AKO65_RS04465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AKO65_RS04470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO65_RS04475	COG0456	acetyltransferase
AKO65_RS04495	COG4720	Psort location CytoplasmicMembrane, score
AKO65_RS04505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO65_RS04510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKO65_RS04540	COG2409	Drug exporters of the RND superfamily
AKO65_RS04550	COG3850	Histidine kinase
AKO65_RS04550	COG5002	protein histidine kinase activity
AKO65_RS04565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKO65_RS04585	COG0583	DNA-binding transcription factor activity
AKO65_RS04590	COG0384	phenazine biosynthesis protein PhzF
AKO65_RS04605	COG2188	Transcriptional regulator
AKO65_RS04610	COG2190	(PTS) system
AKO65_RS04610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS04610	COG1263	PTS System
AKO65_RS04615	COG2723	6-phospho-beta-galactosidase activity
AKO65_RS04625	COG5444	nuclease activity
AKO65_RS04645	COG2814	Major facilitator Superfamily
AKO65_RS04650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKO65_RS04655	COG2814	Major facilitator Superfamily
AKO65_RS04660	COG1609	Transcriptional regulator
AKO65_RS04665	COG1113	amino acid transport
AKO65_RS04680	COG0494	nUDIX hydrolase
AKO65_RS04705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS04705	COG1263	PTS System
AKO65_RS04705	COG2190	(PTS) system
AKO65_RS04710	COG2723	6-phospho-beta-galactosidase activity
AKO65_RS04715	COG3711	transcriptional antiterminator
AKO65_RS04720	COG0457	Tetratricopeptide repeat
AKO65_RS04730	COG1136	(ABC) transporter
AKO65_RS04740	COG2814	Major facilitator Superfamily
AKO65_RS04745	COG1309	transcriptional regulator
AKO65_RS04750	COG3835	regulator
AKO65_RS04755	COG2610	gluconate transmembrane transporter activity
AKO65_RS04760	COG1929	Belongs to the glycerate kinase type-1 family
AKO65_RS04765	COG2824	Alkylphosphonate utilization operon protein PhnA
AKO65_RS04770	COG1131	(ABC) transporter
AKO65_RS04775	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AKO65_RS04785	COG2851	Citrate transporter
AKO65_RS04790	COG1874	Beta-galactosidase
AKO65_RS04800	COG3833	ABC-type maltose transport systems, permease component
AKO65_RS04805	COG1175	transmembrane transport
AKO65_RS04810	COG2182	Extracellular solute-binding protein
AKO65_RS04815	COG1609	Transcriptional regulator
AKO65_RS04820	COG0583	DNA-binding transcription factor activity
AKO65_RS04860	COG1737	Transcriptional regulator
AKO65_RS04865	COG1070	Carbohydrate kinase
AKO65_RS04875	COG4335	DNA alkylation repair
AKO65_RS04880	COG1113	amino acid transport
AKO65_RS04885	COG0840	transmembrane signaling receptor activity
AKO65_RS04890	COG0673	inositol 2-dehydrogenase activity
AKO65_RS04895	COG0789	Transcriptional regulator
AKO65_RS04900	COG0561	phosphatase activity
AKO65_RS04910	COG2226	methyltransferase
AKO65_RS04915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKO65_RS04920	COG0477	Major facilitator Superfamily
AKO65_RS04925	COG2755	lipolytic protein G-D-S-L family
AKO65_RS04925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKO65_RS04935	COG2390	Transcriptional regulator
AKO65_RS04940	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKO65_RS04945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AKO65_RS04950	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AKO65_RS04955	COG1846	Transcriptional regulator
AKO65_RS04960	COG0778	Nitroreductase
AKO65_RS04965	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AKO65_RS04995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKO65_RS05000	COG4721	ABC-type cobalt transport system, permease component
AKO65_RS05005	COG1122	ATPase activity
AKO65_RS05010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO65_RS05020	COG3878	Protein conserved in bacteria
AKO65_RS05025	COG3711	transcriptional antiterminator
AKO65_RS05030	COG2190	(PTS) system
AKO65_RS05030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS05030	COG1263	PTS System
AKO65_RS05035	COG2723	6-phospho-beta-galactosidase activity
AKO65_RS05060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKO65_RS05065	COG2610	gluconate transmembrane transporter activity
AKO65_RS05075	COG2084	Dehydrogenase
AKO65_RS05080	COG1737	Transcriptional regulator
AKO65_RS05095	COG2195	Cleaves the N-terminal amino acid of tripeptides
AKO65_RS05100	COG4842	Belongs to the WXG100 family
AKO65_RS05125	COG1396	sequence-specific DNA binding
AKO65_RS05130	COG0252	asparaginase activity
AKO65_RS05135	COG1027	Aspartate ammonia-lyase
AKO65_RS05140	COG1757	Na H antiporter
AKO65_RS05165	COG3711	transcriptional antiterminator
AKO65_RS05165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS05170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_RS05175	COG1312	Catalyzes the dehydration of D-mannonate
AKO65_RS05180	COG2723	6-phospho-beta-galactosidase activity
AKO65_RS05185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_RS05190	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO65_RS05195	COG0726	polysaccharide deacetylase
AKO65_RS05205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO65_RS05205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO65_RS05210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO65_RS05210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO65_RS05215	COG2514	catechol 2,3-dioxygenase activity
AKO65_RS05220	COG1733	regulation of RNA biosynthetic process
AKO65_RS05225	COG5386	Cell surface protein
AKO65_RS05230	COG5386	Cell surface protein
AKO65_RS05255	COG4509	Sortase family
AKO65_RS05260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AKO65_RS05265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_RS05270	COG1120	ATPase activity
AKO65_RS05275	COG1271	oxidase subunit
AKO65_RS05280	COG1294	oxidase, subunit
AKO65_RS05285	COG4988	ABC transporter
AKO65_RS05290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKO65_RS05300	COG1595	DNA-templated transcription, initiation
AKO65_RS05315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKO65_RS05330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS05330	COG3711	transcriptional antiterminator
AKO65_RS05335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_RS05340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_RS05345	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO65_RS05350	COG1486	melibiose metabolic process
AKO65_RS05365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO65_RS05370	COG3420	alginic acid biosynthetic process
AKO65_RS05380	COG1129	ABC transporter
AKO65_RS05385	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKO65_RS05390	COG2357	RelA SpoT domain protein
AKO65_RS05395	COG0457	Tetratricopeptide repeat
AKO65_RS05400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_RS05405	COG0765	amino acid transport
AKO65_RS05420	COG0346	lactoylglutathione lyase activity
AKO65_RS05425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKO65_RS05430	COG1346	cytolysis
AKO65_RS05435	COG1380	Effector of murein hydrolase LrgA
AKO65_RS05440	COG0583	DNA-binding transcription factor activity
AKO65_RS05445	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AKO65_RS05450	COG0352	thiamine-phosphate diphosphorylase activity
AKO65_RS05465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO65_RS05470	COG3162	membrane
AKO65_RS05480	COG4106	trans-aconitate 2-methyltransferase activity
AKO65_RS05490	COG2246	polysaccharide biosynthetic process
AKO65_RS05505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AKO65_RS05510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKO65_RS05515	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AKO65_RS05525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKO65_RS05530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKO65_RS05535	COG1845	cytochrome c oxidase, subunit III
AKO65_RS05540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AKO65_RS05550	COG0772	Belongs to the SEDS family
AKO65_RS05555	COG0778	Nitroreductase
AKO65_RS05560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO65_RS05570	COG1404	Belongs to the peptidase S8 family
AKO65_RS05580	COG3711	transcriptional antiterminator
AKO65_RS05585	COG1263	PTS System
AKO65_RS05585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS05590	COG1621	beta-fructofuranosidase activity
AKO65_RS05605	COG0351	phosphomethylpyrimidine kinase
AKO65_RS05615	COG1216	Glycosyl transferase, family 2
AKO65_RS05620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKO65_RS05625	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_RS05635	COG2233	PERMEase
AKO65_RS05640	COG2363	Small membrane protein
AKO65_RS05660	COG0463	Glycosyl transferase, family 2
AKO65_RS05665	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_RS05670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO65_RS05675	COG0456	acetyltransferase
AKO65_RS05680	COG2089	acid synthase
AKO65_RS05685	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AKO65_RS05690	COG3980	spore coat polysaccharide biosynthesis protein
AKO65_RS05695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKO65_RS05700	COG1088	dTDP-glucose 4,6-dehydratase activity
AKO65_RS05705	COG1091	dTDP-4-dehydrorhamnose reductase activity
AKO65_RS05710	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AKO65_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS05720	COG0436	Aminotransferase
AKO65_RS05725	COG0151	Belongs to the GarS family
AKO65_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS05735	COG1917	Cupin 2, conserved barrel domain protein
AKO65_RS05740	COG0077	Prephenate dehydratase
AKO65_RS05745	COG2814	Major facilitator Superfamily
AKO65_RS05750	COG1522	sequence-specific DNA binding
AKO65_RS05755	COG2814	Major facilitator Superfamily
AKO65_RS05765	COG0280	phosphate acetyltransferase
AKO65_RS05775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKO65_RS05805	COG5444	nuclease activity
AKO65_RS05855	COG4844	belongs to the
AKO65_RS05860	COG1078	dGTPase activity
AKO65_RS05865	COG3465	dGTPase activity
AKO65_RS05875	COG1942	4-Oxalocrotonate Tautomerase
AKO65_RS05880	COG1994	Peptidase M50
AKO65_RS05890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO65_RS05895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKO65_RS05900	COG0010	Belongs to the arginase family
AKO65_RS05910	COG4506	Protein conserved in bacteria
AKO65_RS05915	COG0018	arginyl-trna synthetase
AKO65_RS05920	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO65_RS05925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO65_RS05930	COG1132	(ABC) transporter
AKO65_RS05935	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO65_RS05945	COG4294	response to UV
AKO65_RS05950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO65_RS05955	COG0247	lactate metabolic process
AKO65_RS05955	COG2181	nitrate reductase activity
AKO65_RS05960	COG0183	Belongs to the thiolase family
AKO65_RS05965	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKO65_RS05970	COG1960	acyl-CoA dehydrogenase activity
AKO65_RS05975	COG1960	acyl-CoA dehydrogenase activity
AKO65_RS06000	COG1131	(ABC) transporter
AKO65_RS06010	COG3343	RNA polymerase activity
AKO65_RS06015	COG0504	CTP synthase activity
AKO65_RS06020	COG4821	SIS domain
AKO65_RS06025	COG2204	response regulator
AKO65_RS06030	COG0191	fructose-bisphosphate aldolase activity
AKO65_RS06035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKO65_RS06040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKO65_RS06045	COG1494	fructose-1,6-bisphosphatase
AKO65_RS06050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKO65_RS06055	COG0254	rRNA binding
AKO65_RS06060	COG1435	thymidine kinase activity
AKO65_RS06065	COG0281	malic enzyme
AKO65_RS06070	COG0679	Auxin Efflux Carrier
AKO65_RS06075	COG0789	Transcriptional regulator
AKO65_RS06080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKO65_RS06085	COG2890	protein-(glutamine-N5) methyltransferase activity
AKO65_RS06100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AKO65_RS06105	COG0009	L-threonylcarbamoyladenylate synthase
AKO65_RS06110	COG1971	Probably functions as a manganese efflux pump
AKO65_RS06115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO65_RS06120	COG0698	ribose 5-phosphate isomerase
AKO65_RS06125	COG4475	Protein of unknown function (DUF436)
AKO65_RS06130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKO65_RS06135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKO65_RS06145	COG0356	it plays a direct role in the translocation of protons across the membrane
AKO65_RS06150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKO65_RS06155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKO65_RS06160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKO65_RS06165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKO65_RS06170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKO65_RS06175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKO65_RS06180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKO65_RS06190	COG4836	Membrane
AKO65_RS06200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKO65_RS06205	COG2385	sporulation resulting in formation of a cellular spore
AKO65_RS06210	COG2304	oxidoreductase activity
AKO65_RS06215	COG2304	oxidoreductase activity
AKO65_RS06225	COG2223	nitrite transmembrane transporter activity
AKO65_RS06230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AKO65_RS06235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AKO65_RS06240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKO65_RS06245	COG0523	cobalamin synthesis protein
AKO65_RS06250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKO65_RS06260	COG1247	-acetyltransferase
AKO65_RS06265	COG0739	heme binding
AKO65_RS06270	COG0347	Belongs to the P(II) protein family
AKO65_RS06275	COG0004	ammonium transporteR
AKO65_RS06280	COG1126	abc transporter atp-binding protein
AKO65_RS06285	COG0765	amino acid transport
AKO65_RS06290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_RS06295	COG0477	Major facilitator Superfamily
AKO65_RS06300	COG0671	phosphoesterase, PA-phosphatase related
AKO65_RS06305	COG2814	Major facilitator Superfamily
AKO65_RS06310	COG1846	Transcriptional regulator
AKO65_RS06315	COG1609	Transcriptional regulator
AKO65_RS06320	COG1077	Cell shape determining protein MreB Mrl
AKO65_RS06325	COG4786	Flagellar basal body rod
AKO65_RS06330	COG4786	Flagellar basal body rod
AKO65_RS06335	COG0457	Tetratricopeptide repeat
AKO65_RS06340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKO65_RS06345	COG1970	mechanosensitive ion channel activity
AKO65_RS06360	COG0561	phosphatase activity
AKO65_RS06365	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_RS06365	COG2202	Pas domain
AKO65_RS06370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKO65_RS06375	COG4715	Zinc finger, swim domain protein
AKO65_RS06380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKO65_RS06385	COG2059	Chromate
AKO65_RS06390	COG2059	Chromate
AKO65_RS06395	COG1522	sequence-specific DNA binding
AKO65_RS06400	COG3527	Alpha-acetolactate decarboxylase
AKO65_RS06405	COG0028	Belongs to the TPP enzyme family
AKO65_RS06410	COG0583	DNA-binding transcription factor activity
AKO65_RS06415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKO65_RS06420	COG1879	ABC-type sugar transport system periplasmic component
AKO65_RS06425	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKO65_RS06430	COG1129	ABC transporter
AKO65_RS06435	COG1869	D-ribose catabolic process
AKO65_RS06440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKO65_RS06445	COG1609	Transcriptional regulator
AKO65_RS06460	COG0697	spore germination
AKO65_RS06465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKO65_RS06475	COG2843	Capsule synthesis protein
AKO65_RS06480	COG0791	NLP P60 protein
AKO65_RS06485	COG0561	phosphatase activity
AKO65_RS06490	COG1316	TRANSCRIPTIONal
AKO65_RS06495	COG2814	Major facilitator Superfamily
AKO65_RS06510	COG0814	amino acid
AKO65_RS06515	COG0697	spore germination
AKO65_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS06525	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AKO65_RS06530	COG1609	Transcriptional regulator
AKO65_RS06535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKO65_RS06540	COG0800	Aldolase
AKO65_RS06545	COG0454	-acetyltransferase
AKO65_RS06555	COG2972	Histidine kinase
AKO65_RS06560	COG2197	response regulator
AKO65_RS06565	COG1653	transport
AKO65_RS06570	COG1175	transmembrane transport
AKO65_RS06580	COG1482	cell wall glycoprotein biosynthetic process
AKO65_RS06585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_RS06590	COG4193	domain, Protein
AKO65_RS06595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_RS06600	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AKO65_RS06605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKO65_RS06615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_RS06620	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKO65_RS06630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_RS06635	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKO65_RS06645	COG1216	Glycosyl transferase, family 2
AKO65_RS06650	COG1682	transport, permease protein
AKO65_RS06655	COG1134	teichoic acid transport
AKO65_RS06660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKO65_RS06665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKO65_RS06670	COG1316	TRANSCRIPTIONal
AKO65_RS06680	COG2247	cell wall binding repeat
AKO65_RS06680	COG2385	sporulation resulting in formation of a cellular spore
AKO65_RS06685	COG2247	cell wall binding repeat
AKO65_RS06685	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_RS06690	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_RS06690	COG2247	cell wall binding repeat
AKO65_RS06705	COG2244	polysaccharide biosynthetic process
AKO65_RS06710	COG0297	glycogen (starch) synthase activity
AKO65_RS06710	COG0438	transferase activity, transferring glycosyl groups
AKO65_RS06715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKO65_RS06720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO65_RS06725	COG3307	-O-antigen
AKO65_RS06730	COG3206	protein involved in exopolysaccharide biosynthesis
AKO65_RS06735	COG1215	transferase activity, transferring glycosyl groups
AKO65_RS06740	COG0438	transferase activity, transferring glycosyl groups
AKO65_RS06745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKO65_RS06750	COG1316	TRANSCRIPTIONal
AKO65_RS06755	COG1739	Uncharacterized protein family UPF0029
AKO65_RS06760	COG4585	Histidine kinase
AKO65_RS06765	COG2197	response regulator
AKO65_RS06770	COG1307	EDD domain protein, DegV family
AKO65_RS06775	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AKO65_RS06785	COG1040	competence protein
AKO65_RS06800	COG3418	PFAM FlgN family protein
AKO65_RS06805	COG1256	bacterial-type flagellum assembly
AKO65_RS06805	COG4786	Flagellar basal body rod
AKO65_RS06810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_RS06820	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AKO65_RS06825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKO65_RS06830	COG1334	flagellar protein FlaG
AKO65_RS06835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AKO65_RS06840	COG1516	flagellar protein fliS
AKO65_RS06855	COG0840	transmembrane signaling receptor activity
AKO65_RS06860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKO65_RS06865	COG0653	protein targeting
AKO65_RS06870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKO65_RS06885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_RS06890	COG2010	Cytochrome c
AKO65_RS06895	COG2884	Cell division ATP-binding protein ftsE
AKO65_RS06900	COG2177	Part of the ABC transporter FtsEX involved in
AKO65_RS06905	COG0791	NLP P60 protein
AKO65_RS06905	COG3883	PFAM NLP P60 protein
AKO65_RS06910	COG0730	response to heat
AKO65_RS06915	COG0793	Belongs to the peptidase S41A family
AKO65_RS06915	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_RS06925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO65_RS06930	COG1733	regulation of RNA biosynthetic process
AKO65_RS06935	COG0778	Nitroreductase
AKO65_RS06940	COG1113	amino acid transport
AKO65_RS06945	COG0463	Glycosyl transferase, family 2
AKO65_RS06950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKO65_RS06955	COG5002	protein histidine kinase activity
AKO65_RS06960	COG0745	RESPONSE REGULATOR receiver
AKO65_RS06970	COG2814	Major facilitator Superfamily
AKO65_RS06975	COG1309	transcriptional regulator
AKO65_RS06980	COG3848	Pyruvate phosphate dikinase
AKO65_RS06980	COG0574	Belongs to the PEP-utilizing enzyme family
AKO65_RS06985	COG4897	Protein conserved in bacteria
AKO65_RS07000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKO65_RS07015	COG3595	metallopeptidase activity
AKO65_RS07020	COG1983	PspC domain protein
AKO65_RS07025	COG1950	PFAM Membrane protein of
AKO65_RS07030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKO65_RS07035	COG2188	Transcriptional regulator
AKO65_RS07040	COG0363	glucosamine-6-phosphate deaminase activity
AKO65_RS07045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AKO65_RS07050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AKO65_RS07055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKO65_RS07060	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AKO65_RS07065	COG0546	phosphoglycolate phosphatase activity
AKO65_RS07070	COG0110	maltose O-acetyltransferase activity
AKO65_RS07075	COG1959	2 iron, 2 sulfur cluster binding
AKO65_RS07080	COG2910	NAD(P)H-binding
AKO65_RS07090	COG4990	cell redox homeostasis
AKO65_RS07095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKO65_RS07100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKO65_RS07105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKO65_RS07110	COG0131	Imidazoleglycerol-phosphate dehydratase
AKO65_RS07115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKO65_RS07120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AKO65_RS07125	COG0107	imidazoleglycerol-phosphate synthase activity
AKO65_RS07130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKO65_RS07130	COG0140	phosphoribosyl-ATP diphosphatase activity
AKO65_RS07135	COG0457	Tetratricopeptide repeat
AKO65_RS07140	COG0791	NLP P60 protein
AKO65_RS07140	COG3883	PFAM NLP P60 protein
AKO65_RS07145	COG0492	ferredoxin-NADP+ reductase activity
AKO65_RS07150	COG1051	belongs to the nudix hydrolase family
AKO65_RS07155	COG1660	Displays ATPase and GTPase activities
AKO65_RS07160	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AKO65_RS07165	COG1481	regulation of sporulation
AKO65_RS07170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS07175	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AKO65_RS07185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO65_RS07190	COG0288	reversible hydration of carbon dioxide
AKO65_RS07195	COG0659	secondary active sulfate transmembrane transporter activity
AKO65_RS07200	COG1694	Mazg nucleotide pyrophosphohydrolase
AKO65_RS07205	COG1611	Belongs to the LOG family
AKO65_RS07210	COG0740	serine-type endopeptidase activity
AKO65_RS07300	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKO65_RS07305	COG0582	viral genome integration into host DNA
AKO65_RS07405	COG3953	SLT domain
AKO65_RS07405	COG5412	phage tail tape measure protein
AKO65_RS07415	COG1388	LysM domain
AKO65_RS07415	COG1705	Flagellar rod assembly protein muramidase FlgJ
AKO65_RS07440	COG4824	toxin secretion phage lysis holin
AKO65_RS07445	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_RS07470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_RS07475	COG1819	glycosyl
AKO65_RS07480	COG0747	negative chemotaxis
AKO65_RS07485	COG0601	transmembrane transport
AKO65_RS07505	COG0488	(ABC) transporter
AKO65_RS07510	COG0726	polysaccharide deacetylase
AKO65_RS07515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_RS07520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_RS07525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_RS07535	COG1396	sequence-specific DNA binding
AKO65_RS07540	COG3944	biosynthesis protein
AKO65_RS07545	COG0489	protein tyrosine kinase activity
AKO65_RS07550	COG1086	Polysaccharide biosynthesis protein
AKO65_RS07555	COG0438	transferase activity, transferring glycosyl groups
AKO65_RS07560	COG1215	transferase activity, transferring glycosyl groups
AKO65_RS07565	COG0438	transferase activity, transferring glycosyl groups
AKO65_RS07575	COG1216	Glycosyl transferase, family 2
AKO65_RS07580	COG5039	Polysaccharide pyruvyl transferase
AKO65_RS07585	COG2244	polysaccharide biosynthetic process
AKO65_RS07590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKO65_RS07595	COG0110	maltose O-acetyltransferase activity
AKO65_RS07600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO65_RS07605	COG0747	negative chemotaxis
AKO65_RS07610	COG0601	transmembrane transport
AKO65_RS07615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO65_RS07620	COG0444	Belongs to the ABC transporter superfamily
AKO65_RS07625	COG4608	Belongs to the ABC transporter superfamily
AKO65_RS07630	COG0534	Mate efflux family protein
AKO65_RS07640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKO65_RS07645	COG2186	Transcriptional regulator
AKO65_RS07650	COG3829	transcription factor binding
AKO65_RS07655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKO65_RS07660	COG0833	amino acid
AKO65_RS07665	COG2390	Transcriptional regulator
AKO65_RS07670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKO65_RS07675	COG0126	phosphoglycerate kinase activity
AKO65_RS07680	COG0149	triose-phosphate isomerase activity
AKO65_RS07685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKO65_RS07690	COG0148	phosphopyruvate hydratase activity
AKO65_RS07700	COG1131	(ABC) transporter
AKO65_RS07720	COG0456	acetyltransferase
AKO65_RS07730	COG2095	MarC family integral membrane protein
AKO65_RS07735	COG1510	regulation of RNA biosynthetic process
AKO65_RS07740	COG1125	glycine betaine transport
AKO65_RS07740	COG0517	IMP dehydrogenase activity
AKO65_RS07745	COG1174	glycine betaine transport
AKO65_RS07750	COG1732	Glycine betaine
AKO65_RS07755	COG1174	glycine betaine transport
AKO65_RS07760	COG1733	regulation of RNA biosynthetic process
AKO65_RS07765	COG1396	sequence-specific DNA binding
AKO65_RS07770	COG1396	sequence-specific DNA binding
AKO65_RS07775	COG1476	TRANSCRIPTIONal
AKO65_RS07780	COG2002	toxin-antitoxin pair type II binding
AKO65_RS07785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKO65_RS07790	COG1647	Serine aminopeptidase, S33
AKO65_RS07795	COG0557	exoribonuclease II activity
AKO65_RS07800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKO65_RS07830	COG1937	Protein conserved in bacteria
AKO65_RS07835	COG2608	mercury ion transmembrane transporter activity
AKO65_RS07840	COG2217	Heavy metal translocating P-type atpase
AKO65_RS07850	COG1027	Aspartate ammonia-lyase
AKO65_RS07855	COG4191	Histidine kinase
AKO65_RS07860	COG0784	Response regulator, receiver
AKO65_RS07865	COG3226	Transcriptional regulator
AKO65_RS07875	COG0803	Belongs to the bacterial solute-binding protein 9 family
AKO65_RS07880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKO65_RS07885	COG1121	(ABC) transporter
AKO65_RS07890	COG2217	Heavy metal translocating P-type atpase
AKO65_RS07895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKO65_RS07900	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AKO65_RS07905	COG2860	membrane
AKO65_RS07910	COG0025	NhaP-type Na H and K H
AKO65_RS07915	COG1940	carbohydrate kinase activity
AKO65_RS07920	COG0656	L-ascorbic acid biosynthetic process
AKO65_RS07925	COG4149	molybdate abc transporter
AKO65_RS07930	COG0725	ABC transporter, periplasmic molybdate-binding protein
AKO65_RS07935	COG1368	sulfuric ester hydrolase activity
AKO65_RS07940	COG1988	membrane-bound metal-dependent
AKO65_RS07960	COG0531	amino acid
AKO65_RS07965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_RS07970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_RS07975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_RS07980	COG1120	ATPase activity
AKO65_RS07985	COG0745	RESPONSE REGULATOR receiver
AKO65_RS07990	COG2205	protein histidine kinase activity
AKO65_RS07995	COG1904	glucuronate isomerase
AKO65_RS08000	COG1609	Transcriptional regulator
AKO65_RS08005	COG0246	Mannitol dehydrogenase
AKO65_RS08010	COG2721	sulfolactate sulfo-lyase activity
AKO65_RS08020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_RS08025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_RS08030	COG1120	ATPase activity
AKO65_RS08035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKO65_RS08040	COG1454	alcohol dehydrogenase
AKO65_RS08055	COG3604	Transcriptional regulator
AKO65_RS08065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKO65_RS08070	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS08075	COG2096	Adenosyltransferase
AKO65_RS08080	COG4758	membrane
AKO65_RS08085	COG1842	Phage shock protein A
AKO65_RS08095	COG4758	membrane
AKO65_RS08100	COG4585	Histidine kinase
AKO65_RS08105	COG2197	response regulator
AKO65_RS08120	COG0814	amino acid
AKO65_RS08125	COG0697	spore germination
AKO65_RS08130	COG0114	fumarate hydratase activity
AKO65_RS08135	COG1309	transcriptional regulator
AKO65_RS08140	COG2205	protein histidine kinase activity
AKO65_RS08140	COG2770	Histidine kinase
AKO65_RS08145	COG0745	RESPONSE REGULATOR receiver
AKO65_RS08150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO65_RS08155	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS08165	COG1120	ATPase activity
AKO65_RS08175	COG5577	PFAM Coat F domain
AKO65_RS08185	COG1024	Enoyl-CoA hydratase
AKO65_RS08185	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKO65_RS08190	COG0183	Belongs to the thiolase family
AKO65_RS08195	COG1960	acyl-CoA dehydrogenase activity
AKO65_RS08200	COG1393	Belongs to the ArsC family
AKO65_RS08205	COG0509	glycine decarboxylation via glycine cleavage system
AKO65_RS08215	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AKO65_RS08220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_RS08230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AKO65_RS08235	COG2011	ABC-type metal ion transport system permease component
AKO65_RS08240	COG1464	Belongs to the NlpA lipoprotein family
AKO65_RS08245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKO65_RS08250	COG0396	ATPase activity
AKO65_RS08255	COG0719	Fe-S assembly protein
AKO65_RS08260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKO65_RS08265	COG0822	iron-sulfur transferase activity
AKO65_RS08270	COG0719	Fe-S assembly protein
AKO65_RS08285	COG1309	transcriptional regulator
AKO65_RS08295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKO65_RS08310	COG2311	Membrane
AKO65_RS08315	COG0745	RESPONSE REGULATOR receiver
AKO65_RS08320	COG0642	Histidine kinase
AKO65_RS08320	COG5002	protein histidine kinase activity
AKO65_RS08345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_RS08350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_RS08355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_RS08370	COG2356	endonuclease I
AKO65_RS08375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKO65_RS08380	COG2814	Major facilitator Superfamily
AKO65_RS08385	COG2140	Oxalate decarboxylase
AKO65_RS08390	COG2508	Transcriptional regulator
AKO65_RS08395	COG1801	Protein of unknown function DUF72
AKO65_RS08400	COG0737	Belongs to the 5'-nucleotidase family
AKO65_RS08405	COG3377	Domain of unknown function (DUF1805)
AKO65_RS08425	COG0739	heme binding
AKO65_RS08430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKO65_RS08440	COG4470	Protein conserved in bacteria
AKO65_RS08445	COG2445	Protein of unknown function DUF86
AKO65_RS08450	COG0647	UMP catabolic process
AKO65_RS08455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKO65_RS08460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO65_RS08465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO65_RS08470	COG0460	homoserine dehydrogenase
AKO65_RS08475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AKO65_RS08480	COG0083	homoserine kinase activity
AKO65_RS08485	COG1506	peptidase
AKO65_RS08485	COG4946	Tricorn protease homolog
AKO65_RS08485	COG0823	Involved in the tonB-independent uptake of proteins
AKO65_RS08490	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKO65_RS08495	COG4837	Protein of unknown function (DUF1462)
AKO65_RS08505	COG1252	NADH dehydrogenase
AKO65_RS08510	COG4844	belongs to the
AKO65_RS08515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKO65_RS08520	COG0316	Belongs to the HesB IscA family
AKO65_RS08535	COG0492	ferredoxin-NADP+ reductase activity
AKO65_RS08540	COG1252	NADH dehydrogenase
AKO65_RS08550	COG3584	3D domain protein
AKO65_RS08555	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AKO65_RS08560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKO65_RS08565	COG2056	Na+-H+ antiporter family
AKO65_RS08570	COG1268	BioY protein
AKO65_RS08575	COG0686	Belongs to the AlaDH PNT family
AKO65_RS08580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AKO65_RS08580	COG2508	Transcriptional regulator
AKO65_RS08585	COG4842	Belongs to the WXG100 family
AKO65_RS08590	COG5417	Belongs to the EsaB family
AKO65_RS08595	COG4499	WXG100 protein secretion system (Wss), protein YukC
AKO65_RS08600	COG1674	ftsk spoiiie
AKO65_RS08600	COG0433	COG0433 Predicted ATPase
AKO65_RS08605	COG1511	domain protein
AKO65_RS08615	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS08620	COG1418	mRNA catabolic process
AKO65_RS08635	COG0628	permease
AKO65_RS08655	COG5506	Protein of unknown function (DUF1694)
AKO65_RS08660	COG1335	isochorismatase
AKO65_RS08665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AKO65_RS08670	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AKO65_RS08685	COG0142	geranyltranstransferase activity
AKO65_RS08695	COG4585	Histidine kinase
AKO65_RS08700	COG2197	response regulator
AKO65_RS08705	COG2050	protein possibly involved in aromatic compounds catabolism
AKO65_RS08710	COG1320	monovalent cation:proton antiporter activity
AKO65_RS08715	COG2212	antiporter activity
AKO65_RS08720	COG1863	multisubunit Na H antiporter MnhE subunit
AKO65_RS08725	COG0651	ATP synthesis coupled electron transport
AKO65_RS08730	COG1006	Multisubunit Na H antiporter MnhC subunit
AKO65_RS08735	COG2111	Na H antiporter
AKO65_RS08740	COG2111	Na H antiporter
AKO65_RS08740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKO65_RS08750	COG3493	citrate carrier protein
AKO65_RS08755	COG1079	Belongs to the binding-protein-dependent transport system permease family
AKO65_RS08760	COG4603	Belongs to the binding-protein-dependent transport system permease family
AKO65_RS08765	COG3845	ABC transporter
AKO65_RS08770	COG1744	ABC transporter substrate-binding protein PnrA-like
AKO65_RS08775	COG4565	transcriptional regulatory protein
AKO65_RS08780	COG3290	protein histidine kinase activity
AKO65_RS08790	COG3011	Protein conserved in bacteria
AKO65_RS08795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO65_RS08800	COG2814	Major facilitator Superfamily
AKO65_RS08805	COG5018	Exonuclease
AKO65_RS08815	COG2205	protein histidine kinase activity
AKO65_RS08820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AKO65_RS08830	COG2267	carboxylic ester hydrolase activity
AKO65_RS08835	COG1522	sequence-specific DNA binding
AKO65_RS08840	COG0436	Aminotransferase
AKO65_RS08845	COG1098	S1 RNA binding domain
AKO65_RS08850	COG2155	Conserved Protein
AKO65_RS08855	COG1979	alcohol dehydrogenase
AKO65_RS08860	COG1979	alcohol dehydrogenase
AKO65_RS08865	COG0166	Belongs to the GPI family
AKO65_RS08880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKO65_RS08890	COG2738	Putative neutral zinc metallopeptidase
AKO65_RS08895	COG1253	flavin adenine dinucleotide binding
AKO65_RS08900	COG0432	Pfam Uncharacterised protein family UPF0047
AKO65_RS08905	COG2070	2-Nitropropane dioxygenase
AKO65_RS08920	COG0840	transmembrane signaling receptor activity
AKO65_RS08925	COG0840	transmembrane signaling receptor activity
AKO65_RS08930	COG0840	transmembrane signaling receptor activity
AKO65_RS08935	COG0840	transmembrane signaling receptor activity
AKO65_RS08940	COG0693	protein deglycase activity
AKO65_RS08945	COG0673	inositol 2-dehydrogenase activity
AKO65_RS08955	COG0628	permease
AKO65_RS08970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKO65_RS08980	COG1396	sequence-specific DNA binding
AKO65_RS08995	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
AKO65_RS09005	COG1595	DNA-templated transcription, initiation
AKO65_RS09010	COG5484	DNA packaging
AKO65_RS09015	COG1783	phage Terminase large subunit
AKO65_RS09020	COG5518	Phage portal protein
AKO65_RS09025	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AKO65_RS09030	COG4653	Phage capsid family
AKO65_RS09075	COG3953	SLT domain
AKO65_RS09075	COG5280	Phage tail tape measure protein TP901
AKO65_RS09075	COG5280	Phage tail tape measure protein TP901
AKO65_RS09075	COG3953	SLT domain
AKO65_RS09080	COG1652	LysM domain
AKO65_RS09085	COG4193	domain, Protein
AKO65_RS09095	COG3628	GPW Gp25 family protein
AKO65_RS09100	COG3299	homolog of phage Mu protein gp47
AKO65_RS09105	COG3778	Protein conserved in bacteria
AKO65_RS09160	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_RS09160	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKO65_RS09175	COG1510	regulation of RNA biosynthetic process
AKO65_RS09180	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_RS09185	COG1454	alcohol dehydrogenase
AKO65_RS09190	COG2318	DinB family
AKO65_RS09195	COG1585	Membrane protein implicated in regulation of membrane protease activity
AKO65_RS09200	COG2268	Band 7 protein
AKO65_RS09205	COG0772	Belongs to the SEDS family
AKO65_RS09210	COG0772	Belongs to the SEDS family
AKO65_RS09215	COG3339	Conserved Protein
AKO65_RS09220	COG1247	-acetyltransferase
AKO65_RS09225	COG3859	Proton-coupled thiamine transporter YuaJ
AKO65_RS09365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO65_RS09370	COG1575	Belongs to the MenA family. Type 1 subfamily
AKO65_RS09375	COG1169	isochorismate synthase
AKO65_RS09380	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AKO65_RS09385	COG0596	Alpha beta hydrolase
AKO65_RS09390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AKO65_RS09395	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_RS09400	COG4948	Mandelate Racemase Muconate Lactonizing
AKO65_RS09410	COG1294	oxidase, subunit
AKO65_RS09415	COG1271	oxidase subunit
AKO65_RS09425	COG0803	Belongs to the bacterial solute-binding protein 9 family
AKO65_RS09425	COG3443	Belongs to the bacterial solute-binding protein 9 family
AKO65_RS09430	COG0288	reversible hydration of carbon dioxide
AKO65_RS09435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKO65_RS09440	COG1854	S-ribosylhomocysteine lyase activity
AKO65_RS09455	COG0783	Belongs to the Dps family
AKO65_RS09465	COG4824	toxin secretion phage lysis holin
AKO65_RS09480	COG2310	stress, protein
AKO65_RS09485	COG0494	nUDIX hydrolase
AKO65_RS09490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKO65_RS09495	COG1116	anion transmembrane transporter activity
AKO65_RS09500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKO65_RS09520	COG1233	COG1233 Phytoene dehydrogenase and related
AKO65_RS09525	COG1506	peptidase
AKO65_RS09535	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKO65_RS09540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKO65_RS09545	COG0367	asparagine synthase
AKO65_RS09550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKO65_RS09555	COG2267	carboxylic ester hydrolase activity
AKO65_RS09565	COG4326	sporulation control protein
AKO65_RS09570	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AKO65_RS09575	COG1242	4 iron, 4 sulfur cluster binding
AKO65_RS09595	COG1725	Transcriptional regulator
AKO65_RS09600	COG1131	(ABC) transporter
AKO65_RS09610	COG1136	(ABC) transporter
AKO65_RS09615	COG0577	efflux transmembrane transporter activity
AKO65_RS09620	COG2433	Pfam Transposase IS66
AKO65_RS09625	COG2202	Pas domain
AKO65_RS09625	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_RS09635	COG0495	leucyl-tRNA aminoacylation
AKO65_RS09640	COG1073	alpha beta
AKO65_RS09645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO65_RS09650	COG0395	ABC-type sugar transport system, permease component
AKO65_RS09655	COG1653	transport
AKO65_RS09660	COG0656	L-ascorbic acid biosynthetic process
AKO65_RS09665	COG2814	Major facilitator Superfamily
AKO65_RS09670	COG1733	regulation of RNA biosynthetic process
AKO65_RS09675	COG2207	Transcriptional regulator
AKO65_RS09680	COG4209	transmembrane transport
AKO65_RS09685	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AKO65_RS09690	COG1653	transport
AKO65_RS09695	COG0673	inositol 2-dehydrogenase activity
AKO65_RS09700	COG5578	integral membrane protein
AKO65_RS09705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO65_RS09715	COG3196	Protein conserved in bacteria
AKO65_RS09720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKO65_RS09730	COG2081	HI0933 family
AKO65_RS09735	COG2244	polysaccharide biosynthetic process
AKO65_RS09740	COG1187	pseudouridine synthase activity
AKO65_RS09745	COG1349	DNA-binding transcription factor activity
AKO65_RS09750	COG2252	PERMEase
AKO65_RS09755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKO65_RS09760	COG3340	Belongs to the peptidase S51 family
AKO65_RS09765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO65_RS09770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKO65_RS09780	COG1597	lipid kinase activity
AKO65_RS09785	COG0510	thiamine kinase activity
AKO65_RS09795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKO65_RS09800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_RS09805	COG0281	malic enzyme
AKO65_RS09810	COG5584	Small secreted protein
AKO65_RS09815	COG1363	Peptidase, m42
AKO65_RS09830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_RS09835	COG4848	Belongs to the UPF0354 family
AKO65_RS09840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_RS09845	COG1674	ftsk spoiiie
AKO65_RS09850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKO65_RS09855	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AKO65_RS09860	COG4980	gas vesicle protein
AKO65_RS09865	COG3118	belongs to the thioredoxin family
AKO65_RS09870	COG1605	Chorismate mutase
AKO65_RS09870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AKO65_RS09875	COG1609	Transcriptional regulator
AKO65_RS09880	COG0123	including yeast histone deacetylase and acetoin utilization protein
AKO65_RS09885	COG0517	IMP dehydrogenase activity
AKO65_RS09890	COG0454	-acetyltransferase
AKO65_RS09895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO65_RS09900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKO65_RS09905	COG2329	Antibiotic biosynthesis monooxygenase
AKO65_RS09910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AKO65_RS09920	COG1335	isochorismatase
AKO65_RS09930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKO65_RS09935	COG1956	GAF domain-containing protein
AKO65_RS09940	COG1309	transcriptional regulator
AKO65_RS09945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO65_RS09950	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AKO65_RS09955	COG1114	Component of the transport system for branched-chain amino acids
AKO65_RS09960	COG1114	Component of the transport system for branched-chain amino acids
AKO65_RS09965	COG1104	cysteine desulfurase activity
AKO65_RS09970	COG0301	tRNA thio-modification
AKO65_RS09980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO65_RS09985	COG1279	arginine transmembrane transporter activity
AKO65_RS10000	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKO65_RS10005	COG0402	S-adenosylhomocysteine deaminase activity
AKO65_RS10010	COG0577	efflux transmembrane transporter activity
AKO65_RS10015	COG1136	(ABC) transporter
AKO65_RS10020	COG1695	Transcriptional regulator
AKO65_RS10025	COG0772	Belongs to the SEDS family
AKO65_RS10030	COG2205	protein histidine kinase activity
AKO65_RS10035	COG0745	RESPONSE REGULATOR receiver
AKO65_RS10040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_RS10045	COG2197	response regulator
AKO65_RS10050	COG4585	Histidine kinase
AKO65_RS10055	COG3239	Fatty acid desaturase
AKO65_RS10065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKO65_RS10070	COG0616	signal peptide processing
AKO65_RS10075	COG1714	RDD family
AKO65_RS10085	COG3874	Sporulation protein YtfJ
AKO65_RS10090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AKO65_RS10095	COG0827	DNA restriction-modification system
AKO65_RS10100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKO65_RS10105	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKO65_RS10110	COG0137	argininosuccinate synthase activity
AKO65_RS10115	COG0165	Argininosuccinate lyase
AKO65_RS10125	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS10130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKO65_RS10135	COG4109	DRTGG domain
AKO65_RS10145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKO65_RS10165	COG0587	DNA-directed DNA polymerase activity
AKO65_RS10170	COG0281	malic enzyme
AKO65_RS10175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKO65_RS10180	COG0825	malonyl-CoA metabolic process
AKO65_RS10185	COG0205	6-phosphofructokinase activity
AKO65_RS10195	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKO65_RS10200	COG0628	permease
AKO65_RS10205	COG2707	UPF0756 membrane protein
AKO65_RS10210	COG0372	Belongs to the citrate synthase family
AKO65_RS10215	COG0538	isocitrate dehydrogenase activity
AKO65_RS10220	COG0039	L-malate dehydrogenase activity
AKO65_RS10225	COG0745	RESPONSE REGULATOR receiver
AKO65_RS10230	COG5002	protein histidine kinase activity
AKO65_RS10235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO65_RS10235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO65_RS10240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKO65_RS10245	COG1971	Probably functions as a manganese efflux pump
AKO65_RS10250	COG0237	dephospho-CoA kinase activity
AKO65_RS10255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKO65_RS10260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKO65_RS10270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKO65_RS10275	COG3611	Membrane attachment protein
AKO65_RS10280	COG1484	DNA-dependent DNA replication
AKO65_RS10285	COG0398	Pfam SNARE associated Golgi protein
AKO65_RS10295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKO65_RS10305	COG1011	Hydrolase
AKO65_RS10315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AKO65_RS10320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKO65_RS10325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKO65_RS10330	COG3326	Membrane
AKO65_RS10340	COG1363	Peptidase, m42
AKO65_RS10345	COG1966	Carbon starvation protein
AKO65_RS10355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKO65_RS10360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKO65_RS10365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_RS10365	COG0072	phenylalanine-tRNA ligase activity
AKO65_RS10370	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKO65_RS10375	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AKO65_RS10380	COG1286	toxin biosynthetic process
AKO65_RS10385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO65_RS10385	COG1796	DNA polymerase
AKO65_RS10390	COG1193	negative regulation of DNA recombination
AKO65_RS10395	COG3766	membrane
AKO65_RS10405	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_RS10410	COG1309	transcriptional regulator
AKO65_RS10415	COG1024	Enoyl-CoA hydratase
AKO65_RS10420	COG2086	electron transfer activity
AKO65_RS10425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AKO65_RS10430	COG3534	alpha-L-arabinofuranosidase
AKO65_RS10435	COG3118	belongs to the thioredoxin family
AKO65_RS10440	COG0322	excinuclease ABC activity
AKO65_RS10445	COG0527	aspartate kinase activity
AKO65_RS10450	COG1719	4-vinyl reductase, 4VR
AKO65_RS10455	COG2009	succinate dehydrogenase
AKO65_RS10460	COG1053	succinate dehydrogenase
AKO65_RS10465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKO65_RS10470	COG0824	Thioesterase
AKO65_RS10475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKO65_RS10475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKO65_RS10480	COG2828	Protein conserved in bacteria
AKO65_RS10485	COG0583	DNA-binding transcription factor activity
AKO65_RS10490	COG2851	Citrate transporter
AKO65_RS10495	COG2197	response regulator
AKO65_RS10500	COG1846	Transcriptional regulator
AKO65_RS10505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKO65_RS10510	COG5401	PFAM Sporulation and spore germination
AKO65_RS10515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKO65_RS10520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKO65_RS10525	COG0622	Phosphoesterase
AKO65_RS10565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO65_RS10570	COG1696	Membrane protein involved in D-alanine export
AKO65_RS10575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO65_RS10580	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AKO65_RS10585	COG3339	Conserved Protein
AKO65_RS10590	COG2706	6-phosphogluconolactonase activity
AKO65_RS10595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO65_RS10600	COG0028	Belongs to the TPP enzyme family
AKO65_RS10605	COG0440	acetolactate synthase activity
AKO65_RS10610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AKO65_RS10615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO65_RS10620	COG0473	3-isopropylmalate dehydrogenase activity
AKO65_RS10625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKO65_RS10630	COG0066	3-isopropylmalate dehydratase activity
AKO65_RS10635	COG1477	protein flavinylation
AKO65_RS10635	COG0457	Tetratricopeptide repeat
AKO65_RS10640	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKO65_RS10645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKO65_RS10650	COG1067	ATP-dependent peptidase activity
AKO65_RS10650	COG0470	DNA polymerase III
AKO65_RS10655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKO65_RS10660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AKO65_RS10680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKO65_RS10685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKO65_RS10690	COG0181	hydroxymethylbilane synthase activity
AKO65_RS10695	COG1587	Uroporphyrinogen-III synthase
AKO65_RS10700	COG0113	porphobilinogen synthase activity
AKO65_RS10705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKO65_RS10710	COG1388	LysM domain
AKO65_RS10715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO65_RS10725	COG0525	valine-tRNA ligase activity
AKO65_RS10730	COG0285	dihydrofolate synthase activity
AKO65_RS10735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKO65_RS10745	COG0424	maF-like protein
AKO65_RS10750	COG2003	Belongs to the UPF0758 family
AKO65_RS10755	COG1077	Cell shape determining protein MreB Mrl
AKO65_RS10765	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AKO65_RS10770	COG0850	regulation of cytokinetic process
AKO65_RS10775	COG2894	cell division
AKO65_RS10780	COG0739	heme binding
AKO65_RS10785	COG1994	Peptidase M50
AKO65_RS10790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKO65_RS10795	COG2868	ribosomal protein
AKO65_RS10800	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKO65_RS10805	COG3290	protein histidine kinase activity
AKO65_RS10810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKO65_RS10815	COG4492	Belongs to the UPF0735 family
AKO65_RS10820	COG0077	Prephenate dehydratase
AKO65_RS10825	COG1827	regulation of RNA biosynthetic process
AKO65_RS10830	COG1104	cysteine desulfurase activity
AKO65_RS10835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AKO65_RS10840	COG0157	Belongs to the NadC ModD family
AKO65_RS10845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKO65_RS10850	COG1388	LysM domain
AKO65_RS10865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKO65_RS10875	COG2112	serine threonine protein kinase
AKO65_RS10885	COG0632	four-way junction helicase activity
AKO65_RS10890	COG2255	four-way junction helicase activity
AKO65_RS10900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKO65_RS10905	COG0343	queuine tRNA-ribosyltransferase activity
AKO65_RS10910	COG1862	Preprotein translocase
AKO65_RS10920	COG2323	membrane
AKO65_RS10925	COG2244	polysaccharide biosynthetic process
AKO65_RS10935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKO65_RS10935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKO65_RS10940	COG0490	domain, Protein
AKO65_RS10945	COG5416	Lipopolysaccharide assembly protein A domain
AKO65_RS10950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKO65_RS10950	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AKO65_RS10955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO65_RS10960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKO65_RS10965	COG1490	D-aminoacyl-tRNA deacylase activity
AKO65_RS10970	COG3103	Sh3 type 3 domain protein
AKO65_RS10970	COG4991	sh3 domain protein
AKO65_RS10970	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_RS10975	COG0124	histidyl-tRNA synthetase
AKO65_RS10985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKO65_RS10990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKO65_RS10995	COG1959	2 iron, 2 sulfur cluster binding
AKO65_RS11000	COG1104	cysteine desulfurase activity
AKO65_RS11005	COG0482	sulfurtransferase activity
AKO65_RS11010	COG0457	Tetratricopeptide repeat
AKO65_RS11015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKO65_RS11020	COG3881	PFAM PRC-barrel domain
AKO65_RS11030	COG0765	amino acid transport
AKO65_RS11035	COG0765	amino acid transport
AKO65_RS11040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_RS11045	COG1126	abc transporter atp-binding protein
AKO65_RS11050	COG0628	permease
AKO65_RS11055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKO65_RS11060	COG4472	Bacterial protein of unknown function (DUF965)
AKO65_RS11065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKO65_RS11070	COG3906	Belongs to the UPF0473 family
AKO65_RS11080	COG1268	BioY protein
AKO65_RS11085	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_RS11090	COG0183	Belongs to the thiolase family
AKO65_RS11095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKO65_RS11100	COG4122	O-methyltransferase activity
AKO65_RS11105	COG0826	peptidase U32
AKO65_RS11110	COG0826	peptidase U32
AKO65_RS11115	COG0572	uridine kinase
AKO65_RS11120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKO65_RS11125	COG0768	penicillin binding
AKO65_RS11140	COG2226	methyltransferase
AKO65_RS11145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKO65_RS11150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO65_RS11155	COG0626	cystathionine gamma-synthase activity
AKO65_RS11165	COG2226	methyltransferase
AKO65_RS11170	COG1063	alcohol dehydrogenase
AKO65_RS11175	COG0583	DNA-binding transcription factor activity
AKO65_RS11180	COG1115	amino acid carrier protein
AKO65_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS11200	COG1063	alcohol dehydrogenase
AKO65_RS11210	COG0765	amino acid transport
AKO65_RS11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_RS11220	COG1126	abc transporter atp-binding protein
AKO65_RS11225	COG1960	acyl-CoA dehydrogenase activity
AKO65_RS11230	COG2602	Beta-lactamase
AKO65_RS11255	COG0657	acetylesterase activity
AKO65_RS11260	COG1733	regulation of RNA biosynthetic process
AKO65_RS11265	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AKO65_RS11270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AKO65_RS11280	COG1846	Transcriptional regulator
AKO65_RS11290	COG1609	Transcriptional regulator
AKO65_RS11305	COG2160	L-arabinose isomerase activity
AKO65_RS11330	COG1122	ATPase activity
AKO65_RS11365	COG0726	polysaccharide deacetylase
AKO65_RS11395	COG0457	Tetratricopeptide repeat
AKO65_RS11405	COG2755	lipolytic protein G-D-S-L family
AKO65_RS11415	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AKO65_RS11420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AKO65_RS11425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKO65_RS11430	COG1534	Rna-binding protein
AKO65_RS11435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKO65_RS11440	COG1713	HD superfamily hydrolase involved in NAD metabolism
AKO65_RS11445	COG0799	negative regulation of ribosome biogenesis
AKO65_RS11450	COG2226	methyltransferase
AKO65_RS11455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO65_RS11460	COG1555	photosystem II stabilization
AKO65_RS11460	COG1596	polysaccharide export
AKO65_RS11465	COG2131	deaminase
AKO65_RS11470	COG0658	competence protein
AKO65_RS11470	COG2333	competence protein COMEC
AKO65_RS11475	COG1466	dna polymerase III delta subunit
AKO65_RS11480	COG0268	Binds directly to 16S ribosomal RNA
AKO65_RS11485	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AKO65_RS11490	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_RS11500	COG0481	GTPase activity
AKO65_RS11505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKO65_RS11510	COG1420	regulation of RNA biosynthetic process
AKO65_RS11515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKO65_RS11520	COG0443	Heat shock 70 kDa protein
AKO65_RS11525	COG0484	heat shock protein binding
AKO65_RS11530	COG2264	protein methyltransferase activity
AKO65_RS11535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKO65_RS11540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKO65_RS11545	COG1283	sodium-dependent phosphate transmembrane transporter activity
AKO65_RS11555	COG1610	YqeY-like protein
AKO65_RS11560	COG1030	water channel activity
AKO65_RS11565	COG4864	UPF0365 protein
AKO65_RS11580	COG0561	phosphatase activity
AKO65_RS11585	COG1702	phosphate starvation-inducible protein PhoH
AKO65_RS11590	COG1480	7TM receptor with intracellular HD hydrolase
AKO65_RS11595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKO65_RS11600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AKO65_RS11605	COG0295	cytidine deaminase activity
AKO65_RS11610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKO65_RS11615	COG1381	Involved in DNA repair and RecF pathway recombination
AKO65_RS11620	COG0752	glycyl-tRNA synthetase alpha subunit
AKO65_RS11625	COG0751	glycine-tRNA ligase activity
AKO65_RS11630	COG0517	IMP dehydrogenase activity
AKO65_RS11635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKO65_RS11640	COG1671	Belongs to the UPF0178 family
AKO65_RS11645	COG0358	DNA primase activity
AKO65_RS11650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKO65_RS11655	COG2010	Cytochrome c
AKO65_RS11660	COG2384	SAM-dependent methyltransferase
AKO65_RS11665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKO65_RS11670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKO65_RS11680	COG0513	Belongs to the DEAD box helicase family
AKO65_RS11695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_RS11700	COG1121	(ABC) transporter
AKO65_RS11705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKO65_RS11710	COG0735	belongs to the Fur family
AKO65_RS11715	COG1940	carbohydrate kinase activity
AKO65_RS11720	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AKO65_RS11725	COG4709	membrane
AKO65_RS11730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKO65_RS11735	COG1388	LysM domain
AKO65_RS11740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO65_RS11745	COG5521	maltodextrose utilization protein MalA
AKO65_RS11750	COG2839	Protein conserved in bacteria
AKO65_RS11755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKO65_RS11760	COG0477	Major facilitator Superfamily
AKO65_RS11765	COG0768	penicillin binding
AKO65_RS11770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AKO65_RS11775	COG0573	inorganic phosphate transmembrane transporter activity
AKO65_RS11780	COG0581	inorganic phosphate transmembrane transporter activity
AKO65_RS11785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKO65_RS11790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKO65_RS11795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKO65_RS11810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKO65_RS11815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKO65_RS11825	COG0457	Tetratricopeptide repeat
AKO65_RS11825	COG0705	Rhomboid family
AKO65_RS11830	COG4483	Protein conserved in bacteria
AKO65_RS11835	COG1940	carbohydrate kinase activity
AKO65_RS11840	COG1368	sulfuric ester hydrolase activity
AKO65_RS11845	COG2866	Carboxypeptidase
AKO65_RS11850	COG2814	Major facilitator Superfamily
AKO65_RS11855	COG0011	TIGRFAM Protein of
AKO65_RS11860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_RS11870	COG1393	Belongs to the ArsC family
AKO65_RS11880	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_RS11885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKO65_RS11890	COG1459	type II secretion system
AKO65_RS11895	COG4537	Required for transformation and DNA binding
AKO65_RS11900	COG4970	Tfp pilus assembly protein FimT
AKO65_RS11935	COG0681	Belongs to the peptidase S26 family
AKO65_RS11955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKO65_RS11960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKO65_RS11965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKO65_RS11970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKO65_RS11975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO65_RS11980	COG0095	Lipoate-protein ligase
AKO65_RS11985	COG1321	iron dependent repressor
AKO65_RS11990	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKO65_RS12000	COG3872	metal-dependent enzyme
AKO65_RS12010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKO65_RS12015	COG0006	proline dipeptidase activity
AKO65_RS12020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKO65_RS12030	COG3854	ATPases associated with a variety of cellular activities
AKO65_RS12070	COG0511	ligase activity, forming carbon-carbon bonds
AKO65_RS12075	COG0439	Biotin carboxylase
AKO65_RS12080	COG1302	Protein conserved in bacteria
AKO65_RS12085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKO65_RS12090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKO65_RS12095	COG1570	exodeoxyribonuclease VII activity
AKO65_RS12100	COG1722	exodeoxyribonuclease VII activity
AKO65_RS12105	COG0142	geranyltranstransferase activity
AKO65_RS12110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKO65_RS12115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AKO65_RS12120	COG1438	arginine binding
AKO65_RS12125	COG0497	DNA recombination
AKO65_RS12130	COG0750	zinc metalloprotease
AKO65_RS12135	COG0745	RESPONSE REGULATOR receiver
AKO65_RS12140	COG0457	Tetratricopeptide repeat
AKO65_RS12145	COG0584	glycerophosphoryl diester phosphodiesterase
AKO65_RS12155	COG3829	transcription factor binding
AKO65_RS12155	COG3290	protein histidine kinase activity
AKO65_RS12160	COG0280	phosphate acetyltransferase
AKO65_RS12170	COG3426	butyrate kinase activity
AKO65_RS12175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO65_RS12180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO65_RS12185	COG0022	dehydrogenase e1 component
AKO65_RS12190	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_RS12200	COG1597	lipid kinase activity
AKO65_RS12210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_RS12215	COG0765	amino acid transport
AKO65_RS12220	COG1126	abc transporter atp-binding protein
AKO65_RS12225	COG4129	membrane
AKO65_RS12230	COG1376	ErfK ybiS ycfS ynhG family protein
AKO65_RS12235	COG0346	lactoylglutathione lyase activity
AKO65_RS12240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKO65_RS12245	COG2195	Cleaves the N-terminal amino acid of tripeptides
AKO65_RS12250	COG0835	chemotaxis
AKO65_RS12255	COG0706	membrane insertase activity
AKO65_RS12265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKO65_RS12270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AKO65_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS12290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_RS12295	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO65_RS12300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_RS12305	COG2723	6-phospho-beta-galactosidase activity
AKO65_RS12310	COG2188	Transcriptional regulator
AKO65_RS12315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKO65_RS12325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_RS12330	COG0596	Alpha beta hydrolase
AKO65_RS12335	COG1902	pentaerythritol trinitrate reductase activity
AKO65_RS12340	COG4187	Peptidase family M20/M25/M40
AKO65_RS12350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO65_RS12355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_RS12360	COG0300	oxidoreductase activity
AKO65_RS12370	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKO65_RS12375	COG1072	(Pantothenic acid kinase))
AKO65_RS12380	COG2211	Major facilitator Superfamily
AKO65_RS12390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKO65_RS12400	COG0456	acetyltransferase
AKO65_RS12405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKO65_RS12405	COG0456	acetyltransferase
AKO65_RS12410	COG4305	rare lipoprotein A
AKO65_RS12415	COG4918	Iron-sulphur cluster biosynthesis
AKO65_RS12425	COG0457	Tetratricopeptide repeat
AKO65_RS12430	COG1073	alpha beta
AKO65_RS12445	COG0667	Aldo Keto reductase
AKO65_RS12450	COG0494	nUDIX hydrolase
AKO65_RS12455	COG1379	DNA repair
AKO65_RS12460	COG2153	protein acetylation
AKO65_RS12470	COG1404	Belongs to the peptidase S8 family
AKO65_RS12475	COG1300	Membrane
AKO65_RS12480	COG0735	belongs to the Fur family
AKO65_RS12490	COG4974	Belongs to the 'phage' integrase family
AKO65_RS12495	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AKO65_RS12500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AKO65_RS12505	COG1686	Belongs to the peptidase S11 family
AKO65_RS12515	COG2172	sigma factor antagonist activity
AKO65_RS12520	COG1191	sigma factor activity
AKO65_RS12540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKO65_RS12555	COG0697	spore germination
AKO65_RS12560	COG0019	diaminopimelate decarboxylase activity
AKO65_RS12565	COG4086	secreted protein
AKO65_RS12570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKO65_RS12575	COG2814	Major facilitator Superfamily
AKO65_RS12595	COG0307	riboflavin synthase, alpha
AKO65_RS12605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKO65_RS12610	COG0456	acetyltransferase
AKO65_RS12615	COG1547	Domain of unknown function (DUF309)
AKO65_RS12620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKO65_RS12625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKO65_RS12635	COG1686	Belongs to the peptidase S11 family
AKO65_RS12640	COG2715	membrane protein required for spore maturation
AKO65_RS12645	COG0700	Nucleoside recognition
AKO65_RS12650	COG1187	pseudouridine synthase activity
AKO65_RS12655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_RS12660	COG1333	cytochrome c biogenesis protein
AKO65_RS12665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKO65_RS12670	COG0745	RESPONSE REGULATOR receiver
AKO65_RS12675	COG5002	protein histidine kinase activity
AKO65_RS12680	COG1595	DNA-templated transcription, initiation
AKO65_RS12695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKO65_RS12700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AKO65_RS12705	COG1141	Ferredoxin
AKO65_RS12710	COG4955	Helix-turn-helix domain
AKO65_RS12715	COG0514	ATP-dependent DNA helicase (RecQ)
AKO65_RS12720	COG1266	CAAX protease self-immunity
AKO65_RS12725	COG1388	LysM domain
AKO65_RS12735	COG1408	metallophosphoesterase
AKO65_RS12740	COG4862	establishment of competence for transformation
AKO65_RS12745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKO65_RS12750	COG0492	ferredoxin-NADP+ reductase activity
AKO65_RS12755	COG2339	peptidase activity
AKO65_RS12760	COG3773	Cell wall hydrolase
AKO65_RS12760	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_RS12765	COG2959	enzyme of heme biosynthesis
AKO65_RS12770	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AKO65_RS12780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKO65_RS12785	COG0539	negative regulation of cytoplasmic translation
AKO65_RS12790	COG1304	FMN binding
AKO65_RS12810	COG1160	GTP binding
AKO65_RS12815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKO65_RS12830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKO65_RS12835	COG0776	regulation of translation
AKO65_RS12840	COG0302	gtp cyclohydrolase
AKO65_RS12850	COG0142	geranyltranstransferase activity
AKO65_RS12855	COG2226	methyltransferase
AKO65_RS12860	COG0142	geranyltranstransferase activity
AKO65_RS12865	COG0105	UTP biosynthetic process
AKO65_RS12870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AKO65_RS12875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKO65_RS12880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKO65_RS12885	COG4401	Chorismate mutase type I
AKO65_RS12895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKO65_RS12900	COG0134	indole-3-glycerol-phosphate synthase activity
AKO65_RS12905	COG0135	phosphoribosylanthranilate isomerase activity
AKO65_RS12910	COG0133	tryptophan synthase activity
AKO65_RS12915	COG0159	tryptophan synthase activity
AKO65_RS12920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKO65_RS12925	COG0287	Prephenate dehydrogenase
AKO65_RS12930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKO65_RS12935	COG0457	Tetratricopeptide repeat
AKO65_RS12940	COG5582	Belongs to the UPF0302 family
AKO65_RS12950	COG0723	plastoquinol--plastocyanin reductase activity
AKO65_RS12955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKO65_RS12960	COG2010	Cytochrome c
AKO65_RS12960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKO65_RS12965	COG4347	Protein of unknown function (DUF1405)
AKO65_RS12975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_RS12980	COG1694	Mazg nucleotide pyrophosphohydrolase
AKO65_RS12985	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKO65_RS12990	COG1803	Methylglyoxal synthase
AKO65_RS12995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO65_RS13000	COG0438	transferase activity, transferring glycosyl groups
AKO65_RS13005	COG0617	tRNA 3'-terminal CCA addition
AKO65_RS13015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKO65_RS13020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKO65_RS13025	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AKO65_RS13030	COG1199	ATP-dependent helicase activity
AKO65_RS13030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKO65_RS13035	COG5353	protein conserved in bacteria
AKO65_RS13040	COG0017	Asparaginyl-tRNA synthetase
AKO65_RS13045	COG3935	DnaD domain protein
AKO65_RS13050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKO65_RS13060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO65_RS13060	COG4499	WXG100 protein secretion system (Wss), protein YukC
AKO65_RS13065	COG3331	DNA recombination
AKO65_RS13095	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO65_RS13100	COG2190	(PTS) system
AKO65_RS13105	COG1902	pentaerythritol trinitrate reductase activity
AKO65_RS13110	COG1205	dead DEAH box helicase
AKO65_RS13110	COG1111	helicase
AKO65_RS13120	COG3620	sequence-specific DNA binding
AKO65_RS13215	COG1802	Transcriptional regulator
AKO65_RS13215	COG4626	Terminase
AKO65_RS13295	COG3942	CHAP domain
AKO65_RS13295	COG1705	Flagellar rod assembly protein muramidase FlgJ
AKO65_RS13320	COG4824	toxin secretion phage lysis holin
AKO65_RS13325	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_RS13345	COG0457	Tetratricopeptide repeat
AKO65_RS13360	COG1205	dead DEAH box helicase
AKO65_RS13360	COG1111	helicase
AKO65_RS13365	COG3359	exonuclease
AKO65_RS13370	COG4474	Belongs to the UPF0398 family
AKO65_RS13375	COG3599	regulation of cell shape
AKO65_RS13380	COG0116	Belongs to the methyltransferase superfamily
AKO65_RS13390	COG1199	ATP-dependent helicase activity
AKO65_RS13395	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AKO65_RS13400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO65_RS13405	COG2233	PERMEase
AKO65_RS13410	COG0726	polysaccharide deacetylase
AKO65_RS13415	COG0456	acetyltransferase
AKO65_RS13415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKO65_RS13420	COG3424	synthase
AKO65_RS13425	COG1755	Isoprenylcysteine carboxyl methyltransferase
AKO65_RS13430	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKO65_RS13440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO65_RS13450	COG0328	RNA-DNA hybrid ribonuclease activity
AKO65_RS13455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKO65_RS13460	COG0328	RNA-DNA hybrid ribonuclease activity
AKO65_RS13475	COG1278	Cold shock
AKO65_RS13485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKO65_RS13490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AKO65_RS13495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AKO65_RS13500	COG0386	Belongs to the glutathione peroxidase family
AKO65_RS13505	COG1418	mRNA catabolic process
AKO65_RS13510	COG1413	lyase activity
AKO65_RS13515	COG0129	dihydroxy-acid dehydratase activity
AKO65_RS13525	COG2521	methyltransferase
AKO65_RS13525	COG2136	Putative SAM-dependent methyltransferase
AKO65_RS13535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKO65_RS13540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKO65_RS13545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AKO65_RS13550	COG0204	Acyl-transferase
AKO65_RS13555	COG1272	protein, Hemolysin III
AKO65_RS13560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AKO65_RS13565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKO65_RS13580	COG1999	signal sequence binding
AKO65_RS13585	COG2755	lipolytic protein G-D-S-L family
AKO65_RS13590	COG4698	Protein conserved in bacteria
AKO65_RS13610	COG1846	Transcriptional regulator
AKO65_RS13615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKO65_RS13620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKO65_RS13625	COG1086	Polysaccharide biosynthesis protein
AKO65_RS13635	COG4641	Protein conserved in bacteria
AKO65_RS13650	COG0463	Glycosyl transferase, family 2
AKO65_RS13655	COG3829	transcription factor binding
AKO65_RS13660	COG1509	lysine 2,3-aminomutase activity
AKO65_RS13670	COG4479	Belongs to the UPF0346 family
AKO65_RS13680	COG0671	phosphoesterase, PA-phosphatase related
AKO65_RS13690	COG0813	purine-nucleoside phosphorylase activity
AKO65_RS13695	COG1876	peptidase activity
AKO65_RS13705	COG2226	methyltransferase
AKO65_RS13710	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_RS13710	COG0793	Belongs to the peptidase S41A family
AKO65_RS13715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO65_RS13725	COG0778	Nitroreductase
AKO65_RS13730	COG1733	regulation of RNA biosynthetic process
AKO65_RS13745	COG2962	Rard protein
AKO65_RS13755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO65_RS13760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO65_RS13765	COG0534	Mate efflux family protein
AKO65_RS13770	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKO65_RS13775	COG1388	LysM domain
AKO65_RS13775	COG0791	NLP P60 protein
AKO65_RS13780	COG2032	superoxide dismutase activity
AKO65_RS13785	COG0714	Associated with various cellular activities
AKO65_RS13790	COG4548	von Willebrand factor, type A
AKO65_RS13795	COG0567	Dehydrogenase, E1 component
AKO65_RS13800	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_RS13805	COG0385	Bile acid
AKO65_RS13810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKO65_RS13815	COG1657	PFAM Prenyltransferase squalene oxidase
AKO65_RS13825	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_RS13845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO65_RS13850	COG0514	ATP-dependent DNA helicase (RecQ)
AKO65_RS13855	COG1388	LysM domain
AKO65_RS13855	COG3584	3D domain protein
AKO65_RS13865	COG2322	membrane
AKO65_RS13870	COG0372	Belongs to the citrate synthase family
AKO65_RS13875	COG2079	MmgE PrpD family protein
AKO65_RS13880	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AKO65_RS13885	COG0741	lytic transglycosylase activity
AKO65_RS13890	COG0531	amino acid
AKO65_RS13895	COG0640	Transcriptional regulator
AKO65_RS13905	COG2378	regulation of single-species biofilm formation
AKO65_RS13910	COG3708	Transcriptional regulator
AKO65_RS13915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_RS13920	COG1309	transcriptional regulator
AKO65_RS13940	COG1994	Peptidase M50
AKO65_RS13945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_RS13950	COG2211	Major facilitator Superfamily
AKO65_RS13960	COG1940	carbohydrate kinase activity
AKO65_RS13965	COG2115	Belongs to the xylose isomerase family
AKO65_RS13970	COG1070	Carbohydrate kinase
AKO65_RS13980	COG0243	molybdopterin cofactor binding
AKO65_RS13990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO65_RS13995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKO65_RS14000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKO65_RS14005	COG0454	-acetyltransferase
AKO65_RS14010	COG4978	Transcriptional regulator
AKO65_RS14010	COG0789	Transcriptional regulator
AKO65_RS14015	COG1132	(ABC) transporter
AKO65_RS14025	COG0583	DNA-binding transcription factor activity
AKO65_RS14030	COG0067	glutamate synthase
AKO65_RS14030	COG0069	glutamate synthase activity
AKO65_RS14030	COG0070	glutamate synthase
AKO65_RS14035	COG0493	'glutamate synthase
AKO65_RS14040	COG2223	nitrite transmembrane transporter activity
AKO65_RS14045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO65_RS14050	COG0243	molybdopterin cofactor binding
AKO65_RS14055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO65_RS14060	COG2146	nitrite reductase [NAD(P)H] activity
AKO65_RS14065	COG2323	membrane
AKO65_RS14070	COG4677	pectinesterase activity
AKO65_RS14075	COG2027	D-alanyl-D-alanine carboxypeptidase
AKO65_RS14080	COG0534	Mate efflux family protein
AKO65_RS14095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO65_RS14105	COG1587	Uroporphyrinogen-III synthase
AKO65_RS14110	COG0586	Pfam SNARE associated Golgi protein
AKO65_RS14115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKO65_RS14120	COG2246	polysaccharide biosynthetic process
AKO65_RS14125	COG0166	Belongs to the GPI family
AKO65_RS14145	COG0247	lactate metabolic process
AKO65_RS14150	COG0277	FAD linked oxidase domain protein
AKO65_RS14155	COG3835	regulator
AKO65_RS14165	COG1942	4-Oxalocrotonate Tautomerase
AKO65_RS14170	COG1349	DNA-binding transcription factor activity
AKO65_RS14175	COG2365	Tyrosine phosphatase family
AKO65_RS14180	COG1649	PFAM Uncharacterised BCR, COG1649
AKO65_RS14185	COG1960	acyl-CoA dehydrogenase activity
AKO65_RS14190	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_RS14195	COG0439	Biotin carboxylase
AKO65_RS14200	COG0511	ligase activity, forming carbon-carbon bonds
AKO65_RS14205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO65_RS14210	COG1024	Enoyl-CoA hydratase
AKO65_RS14215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKO65_RS14220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO65_RS14225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO65_RS14230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKO65_RS14235	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_RS14255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO65_RS14265	COG1105	Belongs to the carbohydrate kinase PfkB family
AKO65_RS14270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_RS14270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_RS14270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS14275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_RS14275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_RS14275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS14285	COG2814	Major facilitator Superfamily
AKO65_RS14290	COG1846	Transcriptional regulator
AKO65_RS14295	COG5444	nuclease activity
AKO65_RS14325	COG1783	phage Terminase large subunit
AKO65_RS14330	COG5518	Phage portal protein
AKO65_RS14335	COG2369	cell adhesion
AKO65_RS14345	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AKO65_RS14350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS14365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKO65_RS14370	COG1609	Transcriptional regulator
AKO65_RS14375	COG1653	transport
AKO65_RS14380	COG1175	transmembrane transport
AKO65_RS14385	COG0395	ABC-type sugar transport system, permease component
AKO65_RS14390	COG1486	melibiose metabolic process
AKO65_RS14395	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_RS14400	COG3507	Belongs to the glycosyl hydrolase 43 family
AKO65_RS14410	COG0745	RESPONSE REGULATOR receiver
AKO65_RS14415	COG2205	protein histidine kinase activity
AKO65_RS14430	COG2190	(PTS) system
AKO65_RS14430	COG1263	PTS System
AKO65_RS14430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS14435	COG2723	6-phospho-beta-galactosidase activity
AKO65_RS14440	COG0789	Transcriptional regulator
AKO65_RS14445	COG0657	acetylesterase activity
AKO65_RS14485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO65_RS14495	COG0640	Transcriptional regulator
AKO65_RS14500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKO65_RS14505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO65_RS14510	COG0110	maltose O-acetyltransferase activity
AKO65_RS14515	COG0473	3-isopropylmalate dehydrogenase activity
AKO65_RS14520	COG0738	Major facilitator superfamily
AKO65_RS14530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKO65_RS14535	COG0187	DNA topoisomerase II activity
AKO65_RS14540	COG1832	CoA-binding protein
AKO65_RS14545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKO65_RS14550	COG4841	protein insertion into membrane
AKO65_RS14560	COG0824	Thioesterase
AKO65_RS14575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_RS14580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKO65_RS14595	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO65_RS14605	COG4846	Membrane protein involved in cytochrome C biogenesis
AKO65_RS14610	COG0785	Cytochrome C biogenesis protein
AKO65_RS14620	COG3763	UPF0154 protein
AKO65_RS14630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AKO65_RS14635	COG4224	UPF0291 protein
AKO65_RS14640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AKO65_RS14645	COG1388	LysM domain
AKO65_RS14650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKO65_RS14665	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_RS14670	COG3209	COG3209 Rhs family protein
AKO65_RS14675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKO65_RS14680	COG3591	Belongs to the peptidase S1B family
AKO65_RS14685	COG2124	cytochrome p450
AKO65_RS14685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKO65_RS14690	COG1309	transcriptional regulator
AKO65_RS14695	COG2323	membrane
AKO65_RS14715	COG1556	Lactate utilization protein
AKO65_RS14720	COG1139	Iron-sulfur cluster binding protein
AKO65_RS14725	COG0247	lactate metabolic process
AKO65_RS14735	COG0702	epimerase
AKO65_RS14740	COG1959	2 iron, 2 sulfur cluster binding
AKO65_RS14750	COG4876	unkown
AKO65_RS14755	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AKO65_RS14760	COG3285	dna ligase
AKO65_RS14760	COG1793	dna ligase
AKO65_RS14765	COG3619	membrane
AKO65_RS14775	COG0457	Tetratricopeptide repeat
AKO65_RS14800	COG5646	InterPro IPR014922
AKO65_RS14825	COG5444	nuclease activity
AKO65_RS14845	COG0604	alcohol dehydrogenase
AKO65_RS14860	COG0457	Tetratricopeptide repeat
AKO65_RS14885	COG0174	glutamine synthetase
AKO65_RS14890	COG0789	Transcriptional regulator
AKO65_RS14895	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AKO65_RS14900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKO65_RS14905	COG0464	growth
AKO65_RS14915	COG4112	unkown
AKO65_RS14920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKO65_RS14925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKO65_RS14930	COG1780	Probably involved in ribonucleotide reductase function
AKO65_RS14945	COG1923	regulation of RNA biosynthetic process
AKO65_RS14950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKO65_RS14975	COG2076	Multidrug Resistance protein
AKO65_RS14980	COG1764	response to oxidative stress
AKO65_RS14985	COG4195	phage-related replication protein
AKO65_RS14990	COG1404	Belongs to the peptidase S8 family
AKO65_RS14995	COG0457	Tetratricopeptide repeat
AKO65_RS15000	COG4195	phage-related replication protein
AKO65_RS15005	COG1329	Transcriptional regulator
AKO65_RS15025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AKO65_RS15030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKO65_RS15040	COG4550	Control of competence regulator ComK, YlbF/YmcA
AKO65_RS15045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKO65_RS15055	COG0156	8-amino-7-oxononanoate synthase activity
AKO65_RS15060	COG1063	alcohol dehydrogenase
AKO65_RS15065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKO65_RS15070	COG2359	stage V sporulation protein S
AKO65_RS15075	COG1692	metallophosphoesterase
AKO65_RS15080	COG1418	mRNA catabolic process
AKO65_RS15085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AKO65_RS15090	COG1546	Belongs to the CinA family
AKO65_RS15090	COG1058	Belongs to the CinA family
AKO65_RS15095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKO65_RS15100	COG1426	Protein conserved in bacteria
AKO65_RS15115	COG0300	oxidoreductase activity
AKO65_RS15120	COG2409	Drug exporters of the RND superfamily
AKO65_RS15120	COG1033	growth of symbiont in host cell
AKO65_RS15130	COG0612	Peptidase, M16
AKO65_RS15135	COG0612	Peptidase, M16
AKO65_RS15140	COG2409	Drug exporters of the RND superfamily
AKO65_RS15140	COG1033	growth of symbiont in host cell
AKO65_RS15145	COG2814	Major facilitator Superfamily
AKO65_RS15150	COG2188	Transcriptional regulator
AKO65_RS15155	COG4980	gas vesicle protein
AKO65_RS15155	COG1674	ftsk spoiiie
AKO65_RS15165	COG0740	serine-type endopeptidase activity
AKO65_RS15170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKO65_RS15180	COG0527	aspartate kinase activity
AKO65_RS15185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKO65_RS15190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKO65_RS15195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO65_RS15200	COG1873	PFAM PRC-barrel domain
AKO65_RS15205	COG0367	asparagine synthase
AKO65_RS15250	COG1260	myo-inositol-1-phosphate synthase
AKO65_RS15255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO65_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS15285	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AKO65_RS15320	COG1132	(ABC) transporter
AKO65_RS15325	COG1132	(ABC) transporter
AKO65_RS15335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO65_RS15340	COG0612	Peptidase, M16
AKO65_RS15345	COG0726	polysaccharide deacetylase
AKO65_RS15350	COG1185	polyribonucleotide nucleotidyltransferase activity
AKO65_RS15355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKO65_RS15360	COG0196	riboflavin kinase activity
AKO65_RS15365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKO65_RS15370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKO65_RS15375	COG1550	Protein conserved in bacteria
AKO65_RS15380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKO65_RS15385	COG1358	cellular component organization or biogenesis
AKO65_RS15390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AKO65_RS15395	COG0195	Participates in both transcription termination and antitermination
AKO65_RS15400	COG0779	Required for maturation of 30S ribosomal subunits
AKO65_RS15410	COG3693	PFAM glycoside hydrolase, family 10
AKO65_RS15425	COG2176	DNA-directed DNA polymerase activity
AKO65_RS15430	COG0442	prolyl-tRNA aminoacylation
AKO65_RS15435	COG0750	zinc metalloprotease
AKO65_RS15440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKO65_RS15445	COG4589	Belongs to the CDS family
AKO65_RS15450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKO65_RS15455	COG0233	cytoplasmic translational termination
AKO65_RS15460	COG0528	UMP kinase activity
AKO65_RS15465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKO65_RS15480	COG1191	sigma factor activity
AKO65_RS15490	COG1776	CheC inhibitor of MCP methylation
AKO65_RS15495	COG0835	chemotaxis
AKO65_RS15500	COG2198	Histidine kinase
AKO65_RS15500	COG0643	Histidine kinase
AKO65_RS15505	COG2201	protein-glutamate methylesterase activity
AKO65_RS15510	COG0455	bacterial-type flagellum organization
AKO65_RS15515	COG1419	protein localization to endoplasmic reticulum
AKO65_RS15520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKO65_RS15525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKO65_RS15530	COG1684	flagellar biosynthetic protein fliR
AKO65_RS15535	COG1987	bacterial-type flagellum assembly
AKO65_RS15540	COG1338	Plays a role in the flagellum-specific transport system
AKO65_RS15545	COG3190	flagellar
AKO65_RS15550	COG2201	protein-glutamate methylesterase activity
AKO65_RS15555	COG1776	CheC inhibitor of MCP methylation
AKO65_RS15555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO65_RS15560	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO65_RS15565	COG1580	Controls the rotational direction of flagella during chemotaxis
AKO65_RS15570	COG1582	Flagellar protein (FlbD)
AKO65_RS15575	COG4786	Flagellar basal body rod
AKO65_RS15580	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AKO65_RS15585	COG3144	bacterial-type flagellum assembly
AKO65_RS15590	COG3334	PFAM MgtE intracellular
AKO65_RS15595	COG2882	bacterial-type flagellum organization
AKO65_RS15600	COG1157	protein secretion by the type III secretion system
AKO65_RS15605	COG1317	bacterial-type flagellum organization
AKO65_RS15610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO65_RS15615	COG1766	The M ring may be actively involved in energy transduction
AKO65_RS15620	COG1677	Flagellar hook-basal body complex protein FliE
AKO65_RS15625	COG1558	bacterial-type flagellum-dependent cell motility
AKO65_RS15630	COG1815	bacterial-type flagellum-dependent cell motility
AKO65_RS15635	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AKO65_RS15640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKO65_RS15645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AKO65_RS15650	COG4974	Belongs to the 'phage' integrase family
AKO65_RS15655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AKO65_RS15660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKO65_RS15665	COG0758	DNA mediated transformation
AKO65_RS15670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKO65_RS15675	COG0045	succinate-CoA ligase (ADP-forming) activity
AKO65_RS15680	COG2257	FlhB HrpN YscU SpaS Family
AKO65_RS15690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKO65_RS15695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AKO65_RS15700	COG0335	large ribosomal subunit rRNA binding
AKO65_RS15705	COG0336	Belongs to the RNA methyltransferase TrmD family
AKO65_RS15710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKO65_RS15720	COG1837	Belongs to the UPF0109 family
AKO65_RS15725	COG0228	four-way junction DNA binding
AKO65_RS15730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKO65_RS15735	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AKO65_RS15740	COG0552	protein localization to endoplasmic reticulum
AKO65_RS15745	COG1196	nuclear chromosome segregation
AKO65_RS15755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO65_RS15760	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS15765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKO65_RS15770	COG0416	fatty acid biosynthetic process
AKO65_RS15775	COG1349	DNA-binding transcription factor activity
AKO65_RS15780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKO65_RS15785	COG1760	l-serine dehydratase
AKO65_RS15790	COG1760	l-serine dehydratase
AKO65_RS15795	COG1461	Dihydroxyacetone kinase
AKO65_RS15800	COG1302	Protein conserved in bacteria
AKO65_RS15805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKO65_RS15815	COG1564	THIamine pyrophosphokinase
AKO65_RS15820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKO65_RS15825	COG1162	GTPase activity
AKO65_RS15830	COG0515	serine threonine protein kinase
AKO65_RS15830	COG2815	serine threonine protein kinase
AKO65_RS15835	COG0631	protein serine/threonine phosphatase activity
AKO65_RS15840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKO65_RS15845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKO65_RS15845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKO65_RS15850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKO65_RS15855	COG0242	peptide deformylase activity
AKO65_RS15860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKO65_RS15865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKO65_RS15870	COG1758	RNA polymerase activity
AKO65_RS15875	COG0194	GDP metabolic process
AKO65_RS15880	COG2052	Domain of unknown function (DUF370)
AKO65_RS15885	COG1561	YicC-like family, N-terminal region
AKO65_RS15890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKO65_RS15900	COG1648	precorrin-2 dehydrogenase activity
AKO65_RS15905	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
AKO65_RS15910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKO65_RS15915	COG0529	Catalyzes the synthesis of activated sulfate
AKO65_RS15920	COG2046	Belongs to the sulfate adenylyltransferase family
AKO65_RS15925	COG0306	phosphate transporter
AKO65_RS15930	COG0175	sulfate reduction
AKO65_RS15935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKO65_RS15940	COG0284	orotidine-5'-phosphate decarboxylase activity
AKO65_RS15945	COG0167	dihydroorotate dehydrogenase activity
AKO65_RS15950	COG0543	2 iron, 2 sulfur cluster binding
AKO65_RS15955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKO65_RS15960	COG0505	Belongs to the CarA family
AKO65_RS15965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKO65_RS15970	COG0540	Belongs to the ATCase OTCase family
AKO65_RS15975	COG2233	PERMEase
AKO65_RS15980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AKO65_RS15985	COG0564	pseudouridine synthase activity
AKO65_RS15990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKO65_RS15995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO65_RS16000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKO65_RS16005	COG3599	regulation of cell shape
AKO65_RS16010	COG2302	S4 RNA-binding domain
AKO65_RS16015	COG0762	integral membrane protein
AKO65_RS16020	COG1799	cell septum assembly
AKO65_RS16025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKO65_RS16030	COG1496	oxidoreductase activity
AKO65_RS16035	COG1873	PFAM PRC-barrel domain
AKO65_RS16040	COG1119	ATPase activity
AKO65_RS16050	COG3732	PTS system glucitol sorbitol-specific
AKO65_RS16055	COG3730	PTS system glucitol sorbitol-specific
AKO65_RS16070	COG2390	Transcriptional regulator
AKO65_RS16075	COG1191	sigma factor activity
AKO65_RS16080	COG1191	sigma factor activity
AKO65_RS16090	COG4412	M6 family metalloprotease domain protein
AKO65_RS16090	COG1404	Belongs to the peptidase S8 family
AKO65_RS16095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKO65_RS16100	COG0849	cell division
AKO65_RS16105	COG3856	small basic protein
AKO65_RS16110	COG3879	Bacterial protein of unknown function (DUF881)
AKO65_RS16115	COG3879	Bacterial protein of unknown function (DUF881)
AKO65_RS16120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AKO65_RS16125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKO65_RS16130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKO65_RS16135	COG0772	Belongs to the SEDS family
AKO65_RS16140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKO65_RS16145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKO65_RS16150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKO65_RS16155	COG0768	penicillin binding
AKO65_RS16160	COG0768	penicillin binding
AKO65_RS16165	COG4839	cell division protein FtsL
AKO65_RS16170	COG0275	rRNA processing
AKO65_RS16175	COG2001	Belongs to the MraZ family
AKO65_RS16180	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AKO65_RS16185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKO65_RS16190	COG0454	-acetyltransferase
AKO65_RS16200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKO65_RS16205	COG1399	metal-binding, possibly nucleic acid-binding protein
AKO65_RS16215	COG3480	Lon protease (S16) C-terminal proteolytic domain
AKO65_RS16220	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKO65_RS16225	COG3314	Sporulation integral membrane protein YlbJ
AKO65_RS16230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKO65_RS16235	COG0742	ribosomal rna small subunit methyltransferase
AKO65_RS16240	COG4471	UPF0298 protein
AKO65_RS16245	COG3679	Belongs to the UPF0342 family
AKO65_RS16265	COG2340	Cysteine-rich secretory protein family
AKO65_RS16270	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AKO65_RS16280	COG3336	cytochrome c oxidase
AKO65_RS16285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AKO65_RS16290	COG1845	cytochrome c oxidase, subunit III
AKO65_RS16295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKO65_RS16300	COG2010	Cytochrome c
AKO65_RS16300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKO65_RS16305	COG0109	protoheme IX farnesyltransferase activity
AKO65_RS16310	COG1612	heme a metabolic process
AKO65_RS16315	COG0415	Belongs to the DNA photolyase family
AKO65_RS16320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AKO65_RS16325	COG0772	Belongs to the SEDS family
AKO65_RS16330	COG4838	Belongs to the UPF0358 family
AKO65_RS16335	COG2066	Belongs to the glutaminase family
AKO65_RS16340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AKO65_RS16345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKO65_RS16355	COG4896	Protein conserved in bacteria
AKO65_RS16365	COG1217	gtp-binding protein TYPA
AKO65_RS16385	COG1595	DNA-templated transcription, initiation
AKO65_RS16395	COG0483	inositol monophosphate 1-phosphatase activity
AKO65_RS16405	COG4493	Belongs to the UPF0637 family
AKO65_RS16410	COG4476	Belongs to the UPF0223 family
AKO65_RS16415	COG1982	Orn Lys Arg decarboxylase major
AKO65_RS16420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_RS16425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO65_RS16430	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_RS16435	COG0022	dehydrogenase e1 component
AKO65_RS16440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO65_RS16455	COG0242	peptide deformylase activity
AKO65_RS16460	COG0561	phosphatase activity
AKO65_RS16465	COG5503	Protein of unknown function (DUF1447)
AKO65_RS16470	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKO65_RS16475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKO65_RS16480	COG0569	domain protein
AKO65_RS16485	COG2105	PFAM AIG2 family protein
AKO65_RS16485	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AKO65_RS16490	COG3852	Histidine kinase
AKO65_RS16495	COG2002	toxin-antitoxin pair type II binding
AKO65_RS16500	COG1077	Cell shape determining protein MreB Mrl
AKO65_RS16505	COG2309	aminopeptidase activity
AKO65_RS16515	COG0488	(ABC) transporter
AKO65_RS16525	COG0681	Belongs to the peptidase S26 family
AKO65_RS16530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS16530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_RS16530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_RS16535	COG1105	Belongs to the carbohydrate kinase PfkB family
AKO65_RS16540	COG1349	DNA-binding transcription factor activity
AKO65_RS16545	COG0577	efflux transmembrane transporter activity
AKO65_RS16550	COG1136	(ABC) transporter
AKO65_RS16555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKO65_RS16570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AKO65_RS16575	COG0314	molybdopterin synthase activity
AKO65_RS16580	COG1763	Mo-molybdopterin cofactor biosynthetic process
AKO65_RS16585	COG0303	'Molybdopterin
AKO65_RS16590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKO65_RS16595	COG0746	molybdenum cofactor guanylyltransferase activity
AKO65_RS16610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_RS16615	COG0450	alkyl hydroperoxide reductase
AKO65_RS16620	COG0668	transmembrane transport
AKO65_RS16630	COG1473	amidohydrolase
AKO65_RS16635	COG2171	N-acyltransferase activity
AKO65_RS16640	COG0716	FMN binding
AKO65_RS16650	COG0716	FMN binding
AKO65_RS16660	COG0583	DNA-binding transcription factor activity
AKO65_RS16665	COG0517	IMP dehydrogenase activity
AKO65_RS16675	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AKO65_RS16680	COG4703	Protein of unknown function (DUF1797)
AKO65_RS16685	COG3546	catalase activity
AKO65_RS16690	COG2200	EAL domain
AKO65_RS16695	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS16700	COG1408	metallophosphoesterase
AKO65_RS16705	COG1376	ErfK ybiS ycfS ynhG family protein
AKO65_RS16710	COG2814	Major facilitator Superfamily
AKO65_RS16730	COG0784	Response regulator, receiver
AKO65_RS16730	COG0835	chemotaxis
AKO65_RS16740	COG1714	RDD family
AKO65_RS16745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKO65_RS16750	COG0436	Aminotransferase
AKO65_RS16755	COG4191	Histidine kinase
AKO65_RS16760	COG0768	penicillin binding
AKO65_RS16765	COG2340	Cysteine-rich secretory protein family
AKO65_RS16770	COG2084	Dehydrogenase
AKO65_RS16780	COG0840	transmembrane signaling receptor activity
AKO65_RS16785	COG1533	DNA photolyase activity
AKO65_RS16795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKO65_RS16800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_RS16805	COG1263	PTS System
AKO65_RS16805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_RS16805	COG2190	(PTS) system
AKO65_RS16810	COG3711	transcriptional antiterminator
AKO65_RS16815	COG1609	Transcriptional regulator
AKO65_RS16820	COG0006	proline dipeptidase activity
AKO65_RS16825	COG2217	Heavy metal translocating P-type atpase
AKO65_RS16830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_RS16835	COG2244	polysaccharide biosynthetic process
AKO65_RS16840	COG3773	Cell wall hydrolase
AKO65_RS16850	COG4873	Protein conserved in bacteria
AKO65_RS16860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKO65_RS16865	COG0602	queuosine metabolic process
AKO65_RS16870	COG0720	synthase
AKO65_RS16875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKO65_RS16880	COG3949	Membrane
AKO65_RS16885	COG0542	response to heat
AKO65_RS16890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AKO65_RS16895	COG1360	Flagellar Motor Protein
AKO65_RS16900	COG1846	Transcriptional regulator
AKO65_RS16905	COG3852	Histidine kinase
AKO65_RS16915	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AKO65_RS16920	COG0235	Class ii aldolase
AKO65_RS16925	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AKO65_RS16930	COG1850	ribulose-bisphosphate carboxylase activity
AKO65_RS16935	COG0436	Aminotransferase
AKO65_RS16940	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AKO65_RS16945	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKO65_RS16950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKO65_RS16955	COG5002	protein histidine kinase activity
AKO65_RS16960	COG3594	Acyltransferase
AKO65_RS16970	COG2323	membrane
AKO65_RS16975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKO65_RS16980	COG0501	Belongs to the peptidase M48B family
AKO65_RS17000	COG1191	sigma factor activity
AKO65_RS17005	COG0861	Integral membrane protein TerC family
AKO65_RS17010	COG0586	Pfam SNARE associated Golgi protein
AKO65_RS17015	COG3300	MHYT domain
AKO65_RS17015	COG5001	Diguanylate cyclase
AKO65_RS17020	COG1846	Transcriptional regulator
AKO65_RS17035	COG0789	Transcriptional regulator
AKO65_RS17045	COG0583	DNA-binding transcription factor activity
AKO65_RS17055	COG2239	Acts as a magnesium transporter
AKO65_RS17065	COG3212	peptidase
AKO65_RS17070	COG3212	peptidase
AKO65_RS17075	COG5002	protein histidine kinase activity
AKO65_RS17075	COG3850	Histidine kinase
AKO65_RS17080	COG0745	RESPONSE REGULATOR receiver
AKO65_RS17095	COG1404	Belongs to the peptidase S8 family
AKO65_RS17100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKO65_RS17105	COG0590	tRNA wobble adenosine to inosine editing
AKO65_RS17110	COG1764	response to oxidative stress
AKO65_RS17115	COG1846	Transcriptional regulator
AKO65_RS17120	COG1764	response to oxidative stress
AKO65_RS17130	COG0457	Tetratricopeptide repeat
AKO65_RS17135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKO65_RS17140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKO65_RS17145	COG0788	formyltetrahydrofolate deformylase activity
AKO65_RS17155	COG2076	Multidrug Resistance protein
AKO65_RS17160	COG2076	Multidrug Resistance protein
AKO65_RS17170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO65_RS17185	COG1695	Transcriptional regulator
AKO65_RS17190	COG1607	acyl-coa hydrolase
AKO65_RS17195	COG1834	amidinotransferase
AKO65_RS17200	COG4608	Belongs to the ABC transporter superfamily
AKO65_RS17205	COG0791	NLP P60 protein
AKO65_RS17210	COG4948	Mandelate Racemase Muconate Lactonizing
AKO65_RS17215	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO65_RS17220	COG4166	transmembrane transport
AKO65_RS17225	COG0444	Belongs to the ABC transporter superfamily
AKO65_RS17230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO65_RS17235	COG0601	transmembrane transport
AKO65_RS17240	COG2362	D-Aminopeptidase
AKO65_RS17245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO65_RS17250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO65_RS17255	COG0346	lactoylglutathione lyase activity
AKO65_RS17260	COG0531	amino acid
AKO65_RS17270	COG2390	Transcriptional regulator
AKO65_RS17275	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS17285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO65_RS17290	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_RS17295	COG0022	dehydrogenase e1 component
AKO65_RS17295	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_RS17300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO65_RS17305	COG1063	alcohol dehydrogenase
AKO65_RS17320	COG3775	system Galactitol-specific IIC component
AKO65_RS17330	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKO65_RS17335	COG4208	sulfate ABC transporter
AKO65_RS17345	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKO65_RS17350	COG0405	Gamma-glutamyltransferase
AKO65_RS17360	COG1392	Phosphate transport regulator
AKO65_RS17365	COG0306	phosphate transporter
AKO65_RS17380	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKO65_RS17380	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_RS17390	COG2856	Zn peptidase
AKO65_RS17395	COG4195	phage-related replication protein
AKO65_RS17415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_RS17420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_RS17425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_RS17430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_RS17440	COG1309	transcriptional regulator
AKO65_RS17450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKO65_RS17485	COG2807	transmembrane transport
AKO65_RS17490	COG0583	DNA-binding transcription factor activity
AKO65_RS17510	COG0583	DNA-binding transcription factor activity
AKO65_RS17535	COG0457	Tetratricopeptide repeat
AKO65_RS17545	COG2364	Membrane
AKO65_RS17550	COG2153	protein acetylation
AKO65_RS17555	COG0457	Tetratricopeptide repeat
AKO65_RS17565	COG0583	DNA-binding transcription factor activity
AKO65_RS17575	COG2807	transmembrane transport
AKO65_RS17595	COG0825	malonyl-CoA metabolic process
AKO65_RS17600	COG0113	porphobilinogen synthase activity
AKO65_RS17735	COG0626	cystathionine gamma-synthase activity
AKO65_RS17740	COG0626	cystathionine gamma-synthase activity
AKO65_RS17745	COG2382	esterase
AKO65_RS17750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKO65_RS17755	COG2153	protein acetylation
AKO65_RS17765	COG0210	DNA helicase
AKO65_RS17815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AKO65_RS17820	COG0351	phosphomethylpyrimidine kinase
AKO65_RS17825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKO65_RS17830	COG2022	thiamine diphosphate biosynthetic process
AKO65_RS17835	COG2104	thiamine diphosphate biosynthetic process
AKO65_RS17845	COG0352	thiamine-phosphate diphosphorylase activity
AKO65_RS17850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKO65_RS17855	COG0569	domain protein
AKO65_RS17855	COG0475	glutathione-regulated potassium exporter activity
AKO65_RS17860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKO65_RS17865	COG0564	pseudouridine synthase activity
AKO65_RS17870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKO65_RS17875	COG2357	RelA SpoT domain protein
AKO65_RS17885	COG4116	CYTH
AKO65_RS17890	COG0741	lytic transglycosylase activity
AKO65_RS17895	COG2346	COG2346, Truncated hemoglobins
AKO65_RS17900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AKO65_RS17905	COG1164	Oligoendopeptidase f
AKO65_RS17915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO65_RS17920	COG4862	establishment of competence for transformation
AKO65_RS17925	COG0861	Integral membrane protein TerC family
AKO65_RS17930	COG1393	Belongs to the ArsC family
AKO65_RS17935	COG0456	acetyltransferase
AKO65_RS17945	COG4608	Belongs to the ABC transporter superfamily
AKO65_RS17950	COG0444	Belongs to the ABC transporter superfamily
AKO65_RS17955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO65_RS17960	COG0601	transmembrane transport
AKO65_RS17965	COG4166	transmembrane transport
AKO65_RS17970	COG0180	Tryptophanyl-tRNA synthetase
AKO65_RS17980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO65_RS17985	COG0601	transmembrane transport
AKO65_RS17995	COG4608	Belongs to the ABC transporter superfamily
AKO65_RS18000	COG0444	Belongs to the ABC transporter superfamily
AKO65_RS18005	COG5504	Zn-dependent protease
AKO65_RS18010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKO65_RS18015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKO65_RS18030	COG1744	ABC transporter substrate-binding protein PnrA-like
AKO65_RS18040	COG2267	carboxylic ester hydrolase activity
AKO65_RS18050	COG2814	Major facilitator Superfamily
AKO65_RS18060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKO65_RS18065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKO65_RS18070	COG0505	Belongs to the CarA family
AKO65_RS18075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKO65_RS18080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKO65_RS18085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKO65_RS18090	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKO65_RS18095	COG2271	Major facilitator Superfamily
AKO65_RS18100	COG0277	FAD linked oxidase domain protein
AKO65_RS18105	COG2151	metal-sulfur cluster biosynthetic enzyme
AKO65_RS18110	COG1073	alpha beta
AKO65_RS18115	COG0561	phosphatase activity
AKO65_RS18135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_RS18140	COG1307	EDD domain protein, DegV family
AKO65_RS18145	COG0840	transmembrane signaling receptor activity
AKO65_RS18150	COG1744	ABC transporter substrate-binding protein PnrA-like
AKO65_RS18155	COG2996	Protein conserved in bacteria
AKO65_RS18160	COG1666	GTP binding
AKO65_RS18165	COG0646	methionine synthase
AKO65_RS18165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKO65_RS18170	COG1410	methionine synthase
AKO65_RS18170	COG0646	methionine synthase
AKO65_RS18205	COG0076	glutamate decarboxylase activity
AKO65_RS18230	COG1917	Cupin 2, conserved barrel domain protein
AKO65_RS18230	COG2207	Transcriptional regulator
AKO65_RS18235	COG0534	Mate efflux family protein
AKO65_RS18240	COG1562	ergosterol biosynthetic process
AKO65_RS18255	COG0367	asparagine synthase
AKO65_RS18270	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKO65_RS18285	COG5337	Spore coat protein CotH
AKO65_RS18325	COG1403	HNH endonuclease
AKO65_RS18330	COG0419	ATPase involved in DNA repair
AKO65_RS18335	COG0420	3'-5' exonuclease activity
AKO65_RS18340	COG1074	ATP-dependent DNA helicase activity
AKO65_RS18345	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AKO65_RS18350	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AKO65_RS18355	COG2259	Doxx family
AKO65_RS18370	COG3180	Ammonia monooxygenase
AKO65_RS18375	COG0681	Belongs to the peptidase S26 family
AKO65_RS18380	COG0398	Pfam SNARE associated Golgi protein
AKO65_RS18395	COG1316	TRANSCRIPTIONal
AKO65_RS18400	COG4607	ABC-type enterochelin transport system periplasmic component
AKO65_RS18405	COG4604	ABC transporter, ATP-binding protein
AKO65_RS18410	COG4605	iron ion homeostasis
AKO65_RS18415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_RS18420	COG2732	(Barnase) inhibitor
AKO65_RS18425	COG2814	Major facilitator Superfamily
AKO65_RS18430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_RS18445	COG4903	ComK protein
AKO65_RS18455	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_RS18460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKO65_RS18460	COG0723	plastoquinol--plastocyanin reductase activity
AKO65_RS18465	COG0840	transmembrane signaling receptor activity
AKO65_RS18470	COG0406	alpha-ribazole phosphatase activity
AKO65_RS18475	COG1404	Belongs to the peptidase S8 family
AKO65_RS18480	COG0501	Belongs to the peptidase M48B family
AKO65_RS18490	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_RS18495	COG0095	Lipoate-protein ligase
AKO65_RS18500	COG1234	tRNA 3'-trailer cleavage
AKO65_RS18505	COG1301	dicarboxylic acid transport
AKO65_RS18510	COG1363	Peptidase, m42
AKO65_RS18515	COG1511	domain protein
AKO65_RS18520	COG1309	transcriptional regulator
AKO65_RS18525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AKO65_RS18530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKO65_RS18535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKO65_RS18540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO65_RS18545	COG2329	Antibiotic biosynthesis monooxygenase
AKO65_RS18555	COG1473	amidohydrolase
AKO65_RS18565	COG4473	ABC transporter
AKO65_RS18570	COG1131	(ABC) transporter
AKO65_RS18575	COG0537	adenosine 5'-monophosphoramidase activity
AKO65_RS18580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AKO65_RS18595	COG4980	gas vesicle protein
AKO65_RS18600	COG1846	Transcriptional regulator
AKO65_RS18620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKO65_RS18630	COG3481	metal-dependent phosphohydrolase, HD sub domain
AKO65_RS18635	COG4717	serine-type aminopeptidase activity
AKO65_RS18640	COG0420	3'-5' exonuclease activity
AKO65_RS18650	COG1024	Enoyl-CoA hydratase
AKO65_RS18660	COG0490	domain, Protein
AKO65_RS18665	COG0475	glutathione-regulated potassium exporter activity
AKO65_RS18675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKO65_RS18680	COG0561	phosphatase activity
AKO65_RS18685	COG3679	Belongs to the UPF0342 family
AKO65_RS18690	COG4399	Belongs to the UPF0754 family
AKO65_RS18695	COG0189	ligase activity
AKO65_RS18700	COG0189	ligase activity
AKO65_RS18710	COG2508	Transcriptional regulator
AKO65_RS18715	COG3842	ATPase activity
AKO65_RS18725	COG0702	epimerase
AKO65_RS18730	COG1132	(ABC) transporter
AKO65_RS18735	COG1132	(ABC) transporter
AKO65_RS18740	COG0589	response to stress
AKO65_RS18745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO65_RS18750	COG0726	polysaccharide deacetylase
AKO65_RS18755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKO65_RS18760	COG0668	transmembrane transport
AKO65_RS18765	COG0584	glycerophosphoryl diester phosphodiesterase
AKO65_RS18770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKO65_RS18785	COG1253	flavin adenine dinucleotide binding
AKO65_RS18790	COG0789	Transcriptional regulator
AKO65_RS18795	COG1253	flavin adenine dinucleotide binding
AKO65_RS18800	COG0204	Acyl-transferase
AKO65_RS18805	COG1595	DNA-templated transcription, initiation
AKO65_RS18820	COG0531	amino acid
AKO65_RS18825	COG1388	LysM domain
AKO65_RS18825	COG0791	NLP P60 protein
AKO65_RS18830	COG1785	Belongs to the alkaline phosphatase family
AKO65_RS18835	COG2719	SpoVR family
AKO65_RS18840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKO65_RS18840	COG1017	nitric oxide dioxygenase activity
AKO65_RS18845	COG1959	2 iron, 2 sulfur cluster binding
AKO65_RS18850	COG0753	catalase activity
AKO65_RS18865	COG2197	response regulator
AKO65_RS18870	COG4585	Histidine kinase
AKO65_RS18870	COG2203	Gaf domain
AKO65_RS18875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKO65_RS18880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKO65_RS18885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AKO65_RS18890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AKO65_RS18895	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AKO65_RS18900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKO65_RS18905	COG3835	regulator
AKO65_RS18925	COG3153	acetyltransferase
AKO65_RS18925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKO65_RS18930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKO65_RS18940	COG0564	pseudouridine synthase activity
AKO65_RS18945	COG3764	Sortase (surface protein transpeptidase)
AKO65_RS18950	COG1525	nuclease
AKO65_RS18950	COG0737	Belongs to the 5'-nucleotidase family
AKO65_RS18950	COG4085	toxin activity
AKO65_RS18955	COG5002	protein histidine kinase activity
AKO65_RS18960	COG5577	PFAM Coat F domain
AKO65_RS18985	COG3706	GGDEF domain
AKO65_RS18990	COG1278	Cold shock
AKO65_RS19000	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKO65_RS19005	COG2814	Major facilitator Superfamily
AKO65_RS19010	COG1566	PFAM secretion protein HlyD family protein
AKO65_RS19015	COG2718	Belongs to the UPF0229 family
AKO65_RS19020	COG2766	serine protein kinase
AKO65_RS19025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKO65_RS19035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKO65_RS19040	COG3382	B3 4 domain protein
AKO65_RS19070	COG1131	(ABC) transporter
AKO65_RS19085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKO65_RS19090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKO65_RS19095	COG1116	anion transmembrane transporter activity
AKO65_RS19105	COG2873	o-acetylhomoserine
AKO65_RS19110	COG0681	Belongs to the peptidase S26 family
AKO65_RS19115	COG1368	sulfuric ester hydrolase activity