locus-tag	class	description
AKO66_RS00005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKO66_RS00010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKO66_RS00015	COG1396	sequence-specific DNA binding
AKO66_RS00020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKO66_RS00025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKO66_RS00030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKO66_RS00035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO66_RS00040	COG0512	Glutamine amidotransferase of anthranilate synthase
AKO66_RS00045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKO66_RS00050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO66_RS00055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKO66_RS00060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKO66_RS00065	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKO66_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKO66_RS00075	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKO66_RS00080	COG0037	tRNA processing
AKO66_RS00085	COG0515	serine threonine protein kinase
AKO66_RS00090	COG2304	oxidoreductase activity
AKO66_RS00095	COG2208	phosphoserine phosphatase activity
AKO66_RS00110	COG1098	S1 RNA binding domain
AKO66_RS00115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AKO66_RS00130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKO66_RS00135	COG3956	TIGRFAM MazG family protein
AKO66_RS00140	COG2244	polysaccharide biosynthetic process
AKO66_RS00145	COG2002	toxin-antitoxin pair type II binding
AKO66_RS00150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKO66_RS00160	COG0193	aminoacyl-tRNA hydrolase activity
AKO66_RS00165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKO66_RS00170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKO66_RS00180	COG2088	sporulation resulting in formation of a cellular spore
AKO66_RS00185	COG0251	oxidation-reduction process
AKO66_RS00190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO66_RS00195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKO66_RS00205	COG4466	Protein conserved in bacteria
AKO66_RS00215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKO66_RS00220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AKO66_RS00225	COG3583	domain protein
AKO66_RS00225	COG3584	3D domain protein
AKO66_RS00230	COG0084	hydrolase, TatD family'
AKO66_RS00235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_RS00235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_RS00240	COG2002	toxin-antitoxin pair type II binding
AKO66_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKO66_RS00250	COG2827	Endonuclease containing a URI domain
AKO66_RS00255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKO66_RS00260	COG4467	Involved in initiation control of chromosome replication
AKO66_RS00265	COG1774	PSP1 C-terminal conserved region
AKO66_RS00270	COG0470	DNA polymerase III
AKO66_RS00275	COG1728	Protein conserved in bacteria
AKO66_RS00280	COG3870	Protein conserved in bacteria
AKO66_RS00285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKO66_RS00290	COG1982	Orn Lys Arg decarboxylase major
AKO66_RS00295	COG3853	Toxic anion resistance protein (TelA)
AKO66_RS00300	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
AKO66_RS00345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKO66_RS00350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKO66_RS00355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AKO66_RS00365	COG0590	tRNA wobble adenosine to inosine editing
AKO66_RS00370	COG1335	isochorismatase
AKO66_RS00375	COG3858	chitin binding
AKO66_RS00375	COG1388	LysM domain
AKO66_RS00380	COG1428	Deoxynucleoside kinase
AKO66_RS00385	COG1428	Deoxynucleoside kinase
AKO66_RS00395	COG0840	transmembrane signaling receptor activity
AKO66_RS00400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKO66_RS00405	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AKO66_RS00410	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AKO66_RS00415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_RS00420	COG1686	Belongs to the peptidase S11 family
AKO66_RS00425	COG0517	IMP dehydrogenase activity
AKO66_RS00425	COG0516	GMP reductase activity
AKO66_RS00460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKO66_RS00465	COG0187	DNA topoisomerase II activity
AKO66_RS00475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKO66_RS00480	COG2501	S4 domain
AKO66_RS00485	COG0592	DNA-directed DNA polymerase activity
AKO66_RS00490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKO66_RS00495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKO66_RS00500	COG0594	ribonuclease P activity
AKO66_RS00505	COG0706	membrane insertase activity
AKO66_RS00510	COG1847	R3H domain protein
AKO66_RS00515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKO66_RS00520	COG0445	tRNA wobble uridine modification
AKO66_RS00525	COG0357	Ribosomal RNA small subunit methyltransferase G
AKO66_RS00530	COG1475	DNA binding
AKO66_RS00540	COG1192	Involved in chromosome partitioning
AKO66_RS00545	COG1475	DNA binding
AKO66_RS00555	COG3949	Membrane
AKO66_RS00570	COG4481	Protein conserved in bacteria
AKO66_RS00575	COG0012	GTP binding
AKO66_RS00580	COG0360	Binds together with S18 to 16S ribosomal RNA
AKO66_RS00585	COG0629	single-stranded DNA binding
AKO66_RS00590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKO66_RS00595	COG1125	glycine betaine transport
AKO66_RS00595	COG0517	IMP dehydrogenase activity
AKO66_RS00600	COG1174	glycine betaine transport
AKO66_RS00605	COG0346	lactoylglutathione lyase activity
AKO66_RS00610	COG0400	carboxylic ester hydrolase activity
AKO66_RS00615	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKO66_RS00620	COG0753	catalase activity
AKO66_RS00630	COG1595	DNA-templated transcription, initiation
AKO66_RS00640	COG1227	inorganic diphosphatase activity
AKO66_RS00645	COG4241	membrane
AKO66_RS00650	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AKO66_RS00655	COG0359	binds to the 23S rRNA
AKO66_RS00660	COG2807	transmembrane transport
AKO66_RS00665	COG3093	addiction module antidote protein HigA
AKO66_RS00670	COG2819	hydrolase of the alpha beta superfamily
AKO66_RS00675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_RS00680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_RS00680	COG2207	Transcriptional regulator
AKO66_RS00685	COG2819	hydrolase of the alpha beta superfamily
AKO66_RS00705	COG0305	Participates in initiation and elongation during chromosome replication
AKO66_RS00710	COG0346	lactoylglutathione lyase activity
AKO66_RS00715	COG2124	cytochrome p450
AKO66_RS00720	COG1309	transcriptional regulator
AKO66_RS00725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKO66_RS00730	COG2311	Membrane
AKO66_RS00740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKO66_RS00765	COG0745	RESPONSE REGULATOR receiver
AKO66_RS00770	COG5002	protein histidine kinase activity
AKO66_RS00775	COG4863	YycH protein
AKO66_RS00780	COG4853	Protein conserved in bacteria
AKO66_RS00785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AKO66_RS00790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO66_RS00795	COG0456	acetyltransferase
AKO66_RS00815	COG4720	Psort location CytoplasmicMembrane, score
AKO66_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO66_RS00830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKO66_RS00860	COG2409	Drug exporters of the RND superfamily
AKO66_RS00870	COG5002	protein histidine kinase activity
AKO66_RS00870	COG3850	Histidine kinase
AKO66_RS00885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKO66_RS00905	COG0583	DNA-binding transcription factor activity
AKO66_RS00910	COG0384	phenazine biosynthesis protein PhzF
AKO66_RS00925	COG2188	Transcriptional regulator
AKO66_RS00930	COG1263	PTS System
AKO66_RS00930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS00930	COG2190	(PTS) system
AKO66_RS00935	COG2723	6-phospho-beta-galactosidase activity
AKO66_RS00945	COG5444	nuclease activity
AKO66_RS00965	COG2814	Major facilitator Superfamily
AKO66_RS00970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKO66_RS00975	COG2814	Major facilitator Superfamily
AKO66_RS00980	COG1609	Transcriptional regulator
AKO66_RS00985	COG1113	amino acid transport
AKO66_RS01000	COG0494	nUDIX hydrolase
AKO66_RS01025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS01025	COG1263	PTS System
AKO66_RS01025	COG2190	(PTS) system
AKO66_RS01030	COG2723	6-phospho-beta-galactosidase activity
AKO66_RS01035	COG3711	transcriptional antiterminator
AKO66_RS01040	COG0457	Tetratricopeptide repeat
AKO66_RS01050	COG1136	(ABC) transporter
AKO66_RS01060	COG2814	Major facilitator Superfamily
AKO66_RS01065	COG1309	transcriptional regulator
AKO66_RS01070	COG3835	regulator
AKO66_RS01075	COG2610	gluconate transmembrane transporter activity
AKO66_RS01080	COG1929	Belongs to the glycerate kinase type-1 family
AKO66_RS01085	COG2824	Alkylphosphonate utilization operon protein PhnA
AKO66_RS01090	COG1131	(ABC) transporter
AKO66_RS01095	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AKO66_RS01105	COG2851	Citrate transporter
AKO66_RS01110	COG1874	Beta-galactosidase
AKO66_RS01120	COG3833	ABC-type maltose transport systems, permease component
AKO66_RS01125	COG1175	transmembrane transport
AKO66_RS01130	COG2182	Extracellular solute-binding protein
AKO66_RS01135	COG1609	Transcriptional regulator
AKO66_RS01140	COG0583	DNA-binding transcription factor activity
AKO66_RS01180	COG1737	Transcriptional regulator
AKO66_RS01185	COG1070	Carbohydrate kinase
AKO66_RS01195	COG4335	DNA alkylation repair
AKO66_RS01200	COG1113	amino acid transport
AKO66_RS01205	COG0840	transmembrane signaling receptor activity
AKO66_RS01210	COG0673	inositol 2-dehydrogenase activity
AKO66_RS01215	COG0789	Transcriptional regulator
AKO66_RS01220	COG0561	phosphatase activity
AKO66_RS01230	COG2226	methyltransferase
AKO66_RS01235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKO66_RS01240	COG0477	Major facilitator Superfamily
AKO66_RS01245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKO66_RS01245	COG2755	lipolytic protein G-D-S-L family
AKO66_RS01255	COG2390	Transcriptional regulator
AKO66_RS01260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKO66_RS01265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AKO66_RS01270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AKO66_RS01275	COG1846	Transcriptional regulator
AKO66_RS01280	COG0778	Nitroreductase
AKO66_RS01285	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AKO66_RS01320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKO66_RS01325	COG4721	ABC-type cobalt transport system, permease component
AKO66_RS01330	COG1122	ATPase activity
AKO66_RS01335	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO66_RS01345	COG3878	Protein conserved in bacteria
AKO66_RS01350	COG3711	transcriptional antiterminator
AKO66_RS01355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS01355	COG1263	PTS System
AKO66_RS01355	COG2190	(PTS) system
AKO66_RS01360	COG2723	6-phospho-beta-galactosidase activity
AKO66_RS01385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKO66_RS01390	COG2610	gluconate transmembrane transporter activity
AKO66_RS01400	COG2084	Dehydrogenase
AKO66_RS01405	COG1737	Transcriptional regulator
AKO66_RS01420	COG2195	Cleaves the N-terminal amino acid of tripeptides
AKO66_RS01425	COG4842	Belongs to the WXG100 family
AKO66_RS01450	COG1396	sequence-specific DNA binding
AKO66_RS01455	COG0252	asparaginase activity
AKO66_RS01460	COG1027	Aspartate ammonia-lyase
AKO66_RS01465	COG1757	Na H antiporter
AKO66_RS01490	COG3711	transcriptional antiterminator
AKO66_RS01490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS01495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_RS01500	COG1312	Catalyzes the dehydration of D-mannonate
AKO66_RS01505	COG2723	6-phospho-beta-galactosidase activity
AKO66_RS01510	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_RS01515	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO66_RS01520	COG0726	polysaccharide deacetylase
AKO66_RS01530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO66_RS01530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO66_RS01535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO66_RS01535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO66_RS01540	COG2514	catechol 2,3-dioxygenase activity
AKO66_RS01545	COG1733	regulation of RNA biosynthetic process
AKO66_RS01550	COG5386	Cell surface protein
AKO66_RS01555	COG5386	Cell surface protein
AKO66_RS01580	COG4509	Sortase family
AKO66_RS01585	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AKO66_RS01590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_RS01595	COG1120	ATPase activity
AKO66_RS01600	COG1271	oxidase subunit
AKO66_RS01605	COG1294	oxidase, subunit
AKO66_RS01610	COG4988	ABC transporter
AKO66_RS01615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKO66_RS01625	COG1595	DNA-templated transcription, initiation
AKO66_RS01640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKO66_RS01655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS01655	COG3711	transcriptional antiterminator
AKO66_RS01660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_RS01665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_RS01670	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO66_RS01675	COG1486	melibiose metabolic process
AKO66_RS01690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO66_RS01695	COG3420	alginic acid biosynthetic process
AKO66_RS01705	COG1129	ABC transporter
AKO66_RS01710	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKO66_RS01715	COG2357	RelA SpoT domain protein
AKO66_RS01720	COG0457	Tetratricopeptide repeat
AKO66_RS01725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_RS01730	COG0765	amino acid transport
AKO66_RS01745	COG0346	lactoylglutathione lyase activity
AKO66_RS01750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKO66_RS01755	COG1346	cytolysis
AKO66_RS01760	COG1380	Effector of murein hydrolase LrgA
AKO66_RS01765	COG0583	DNA-binding transcription factor activity
AKO66_RS01770	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AKO66_RS01775	COG0352	thiamine-phosphate diphosphorylase activity
AKO66_RS01790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO66_RS01795	COG3162	membrane
AKO66_RS01805	COG4106	trans-aconitate 2-methyltransferase activity
AKO66_RS01815	COG2246	polysaccharide biosynthetic process
AKO66_RS01830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AKO66_RS01835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKO66_RS01840	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AKO66_RS01850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKO66_RS01855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKO66_RS01860	COG1845	cytochrome c oxidase, subunit III
AKO66_RS01865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AKO66_RS01875	COG0772	Belongs to the SEDS family
AKO66_RS01880	COG0778	Nitroreductase
AKO66_RS01885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO66_RS01895	COG1404	Belongs to the peptidase S8 family
AKO66_RS01905	COG3711	transcriptional antiterminator
AKO66_RS01910	COG1263	PTS System
AKO66_RS01910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS01915	COG1621	beta-fructofuranosidase activity
AKO66_RS01930	COG0351	phosphomethylpyrimidine kinase
AKO66_RS01940	COG1216	Glycosyl transferase, family 2
AKO66_RS01945	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKO66_RS01950	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_RS01960	COG2233	PERMEase
AKO66_RS01965	COG2363	Small membrane protein
AKO66_RS01985	COG0463	Glycosyl transferase, family 2
AKO66_RS01990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_RS01995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO66_RS02000	COG0456	acetyltransferase
AKO66_RS02005	COG2089	acid synthase
AKO66_RS02010	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AKO66_RS02015	COG3980	spore coat polysaccharide biosynthesis protein
AKO66_RS02020	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKO66_RS02025	COG1088	dTDP-glucose 4,6-dehydratase activity
AKO66_RS02030	COG1091	dTDP-4-dehydrorhamnose reductase activity
AKO66_RS02035	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AKO66_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS02045	COG0436	Aminotransferase
AKO66_RS02050	COG0151	Belongs to the GarS family
AKO66_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS02060	COG1917	Cupin 2, conserved barrel domain protein
AKO66_RS02065	COG0077	Prephenate dehydratase
AKO66_RS02070	COG2814	Major facilitator Superfamily
AKO66_RS02075	COG1522	sequence-specific DNA binding
AKO66_RS02080	COG2814	Major facilitator Superfamily
AKO66_RS02090	COG0280	phosphate acetyltransferase
AKO66_RS02100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKO66_RS02130	COG5444	nuclease activity
AKO66_RS02180	COG4844	belongs to the
AKO66_RS02185	COG1078	dGTPase activity
AKO66_RS02190	COG3465	dGTPase activity
AKO66_RS02200	COG1942	4-Oxalocrotonate Tautomerase
AKO66_RS02205	COG1994	Peptidase M50
AKO66_RS02215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO66_RS02220	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKO66_RS02225	COG0010	Belongs to the arginase family
AKO66_RS02235	COG4506	Protein conserved in bacteria
AKO66_RS02240	COG0018	arginyl-trna synthetase
AKO66_RS02245	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO66_RS02250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO66_RS02255	COG1132	(ABC) transporter
AKO66_RS02260	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO66_RS02270	COG4294	response to UV
AKO66_RS02275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO66_RS02280	COG0247	lactate metabolic process
AKO66_RS02280	COG2181	nitrate reductase activity
AKO66_RS02285	COG0183	Belongs to the thiolase family
AKO66_RS02290	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKO66_RS02295	COG1960	acyl-CoA dehydrogenase activity
AKO66_RS02300	COG1960	acyl-CoA dehydrogenase activity
AKO66_RS02325	COG1131	(ABC) transporter
AKO66_RS02335	COG3343	RNA polymerase activity
AKO66_RS02340	COG0504	CTP synthase activity
AKO66_RS02345	COG4821	SIS domain
AKO66_RS02350	COG2204	response regulator
AKO66_RS02355	COG0191	fructose-bisphosphate aldolase activity
AKO66_RS02360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKO66_RS02365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKO66_RS02370	COG1494	fructose-1,6-bisphosphatase
AKO66_RS02375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKO66_RS02380	COG0254	rRNA binding
AKO66_RS02385	COG1435	thymidine kinase activity
AKO66_RS02390	COG0281	malic enzyme
AKO66_RS02395	COG0679	Auxin Efflux Carrier
AKO66_RS02400	COG0789	Transcriptional regulator
AKO66_RS02405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKO66_RS02410	COG2890	protein-(glutamine-N5) methyltransferase activity
AKO66_RS02425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AKO66_RS02430	COG0009	L-threonylcarbamoyladenylate synthase
AKO66_RS02435	COG1971	Probably functions as a manganese efflux pump
AKO66_RS02440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO66_RS02445	COG0698	ribose 5-phosphate isomerase
AKO66_RS02450	COG4475	Protein of unknown function (DUF436)
AKO66_RS02455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKO66_RS02460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKO66_RS02470	COG0356	it plays a direct role in the translocation of protons across the membrane
AKO66_RS02475	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKO66_RS02480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKO66_RS02485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKO66_RS02490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKO66_RS02495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKO66_RS02500	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKO66_RS02505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKO66_RS02515	COG4836	Membrane
AKO66_RS02525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKO66_RS02530	COG2385	sporulation resulting in formation of a cellular spore
AKO66_RS02535	COG2304	oxidoreductase activity
AKO66_RS02540	COG2304	oxidoreductase activity
AKO66_RS02550	COG2223	nitrite transmembrane transporter activity
AKO66_RS02555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AKO66_RS02560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AKO66_RS02565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKO66_RS02570	COG0523	cobalamin synthesis protein
AKO66_RS02575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKO66_RS02585	COG1247	-acetyltransferase
AKO66_RS02590	COG0739	heme binding
AKO66_RS02595	COG0347	Belongs to the P(II) protein family
AKO66_RS02600	COG0004	ammonium transporteR
AKO66_RS02605	COG1126	abc transporter atp-binding protein
AKO66_RS02610	COG0765	amino acid transport
AKO66_RS02615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_RS02620	COG0477	Major facilitator Superfamily
AKO66_RS02625	COG0671	phosphoesterase, PA-phosphatase related
AKO66_RS02630	COG2814	Major facilitator Superfamily
AKO66_RS02635	COG1846	Transcriptional regulator
AKO66_RS02640	COG1609	Transcriptional regulator
AKO66_RS02645	COG1077	Cell shape determining protein MreB Mrl
AKO66_RS02650	COG4786	Flagellar basal body rod
AKO66_RS02655	COG4786	Flagellar basal body rod
AKO66_RS02660	COG0457	Tetratricopeptide repeat
AKO66_RS02665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKO66_RS02670	COG1970	mechanosensitive ion channel activity
AKO66_RS02685	COG0561	phosphatase activity
AKO66_RS02690	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_RS02690	COG2202	Pas domain
AKO66_RS02695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKO66_RS02700	COG4715	Zinc finger, swim domain protein
AKO66_RS02705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKO66_RS02710	COG2059	Chromate
AKO66_RS02715	COG2059	Chromate
AKO66_RS02720	COG1522	sequence-specific DNA binding
AKO66_RS02725	COG3527	Alpha-acetolactate decarboxylase
AKO66_RS02730	COG0028	Belongs to the TPP enzyme family
AKO66_RS02735	COG0583	DNA-binding transcription factor activity
AKO66_RS02740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKO66_RS02745	COG1879	ABC-type sugar transport system periplasmic component
AKO66_RS02750	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKO66_RS02755	COG1129	ABC transporter
AKO66_RS02760	COG1869	D-ribose catabolic process
AKO66_RS02765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKO66_RS02770	COG1609	Transcriptional regulator
AKO66_RS02785	COG0697	spore germination
AKO66_RS02790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKO66_RS02800	COG2843	Capsule synthesis protein
AKO66_RS02805	COG0791	NLP P60 protein
AKO66_RS02810	COG0561	phosphatase activity
AKO66_RS02815	COG1316	TRANSCRIPTIONal
AKO66_RS02820	COG2814	Major facilitator Superfamily
AKO66_RS02835	COG0814	amino acid
AKO66_RS02840	COG0697	spore germination
AKO66_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS02850	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AKO66_RS02855	COG1609	Transcriptional regulator
AKO66_RS02860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKO66_RS02865	COG0800	Aldolase
AKO66_RS02870	COG0454	-acetyltransferase
AKO66_RS02880	COG2972	Histidine kinase
AKO66_RS02885	COG2197	response regulator
AKO66_RS02890	COG1653	transport
AKO66_RS02895	COG1175	transmembrane transport
AKO66_RS02905	COG1482	cell wall glycoprotein biosynthetic process
AKO66_RS02910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_RS02915	COG4193	domain, Protein
AKO66_RS02920	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_RS02925	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AKO66_RS02930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKO66_RS02940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_RS02945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKO66_RS02955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_RS02960	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKO66_RS02970	COG1216	Glycosyl transferase, family 2
AKO66_RS02975	COG1682	transport, permease protein
AKO66_RS02980	COG1134	teichoic acid transport
AKO66_RS02985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKO66_RS02990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKO66_RS02995	COG1316	TRANSCRIPTIONal
AKO66_RS03005	COG2247	cell wall binding repeat
AKO66_RS03005	COG2385	sporulation resulting in formation of a cellular spore
AKO66_RS03010	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_RS03010	COG2247	cell wall binding repeat
AKO66_RS03015	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_RS03015	COG2247	cell wall binding repeat
AKO66_RS03030	COG2244	polysaccharide biosynthetic process
AKO66_RS03035	COG0297	glycogen (starch) synthase activity
AKO66_RS03035	COG0438	transferase activity, transferring glycosyl groups
AKO66_RS03040	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKO66_RS03045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO66_RS03050	COG3307	-O-antigen
AKO66_RS03055	COG3206	protein involved in exopolysaccharide biosynthesis
AKO66_RS03060	COG1215	transferase activity, transferring glycosyl groups
AKO66_RS03065	COG0438	transferase activity, transferring glycosyl groups
AKO66_RS03070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKO66_RS03075	COG1316	TRANSCRIPTIONal
AKO66_RS03080	COG1739	Uncharacterized protein family UPF0029
AKO66_RS03085	COG4585	Histidine kinase
AKO66_RS03090	COG2197	response regulator
AKO66_RS03095	COG1307	EDD domain protein, DegV family
AKO66_RS03100	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AKO66_RS03110	COG1040	competence protein
AKO66_RS03125	COG3418	PFAM FlgN family protein
AKO66_RS03130	COG1256	bacterial-type flagellum assembly
AKO66_RS03130	COG4786	Flagellar basal body rod
AKO66_RS03135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_RS03145	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AKO66_RS03150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKO66_RS03155	COG1334	flagellar protein FlaG
AKO66_RS03160	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AKO66_RS03165	COG1516	flagellar protein fliS
AKO66_RS03180	COG0840	transmembrane signaling receptor activity
AKO66_RS03185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKO66_RS03190	COG0653	protein targeting
AKO66_RS03195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKO66_RS03210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_RS03215	COG2010	Cytochrome c
AKO66_RS03220	COG2884	Cell division ATP-binding protein ftsE
AKO66_RS03225	COG2177	Part of the ABC transporter FtsEX involved in
AKO66_RS03230	COG0791	NLP P60 protein
AKO66_RS03230	COG3883	PFAM NLP P60 protein
AKO66_RS03235	COG0730	response to heat
AKO66_RS03240	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_RS03240	COG0793	Belongs to the peptidase S41A family
AKO66_RS03250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO66_RS03255	COG1733	regulation of RNA biosynthetic process
AKO66_RS03260	COG0778	Nitroreductase
AKO66_RS03265	COG1113	amino acid transport
AKO66_RS03270	COG0463	Glycosyl transferase, family 2
AKO66_RS03275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKO66_RS03280	COG5002	protein histidine kinase activity
AKO66_RS03285	COG0745	RESPONSE REGULATOR receiver
AKO66_RS03295	COG2814	Major facilitator Superfamily
AKO66_RS03300	COG1309	transcriptional regulator
AKO66_RS03305	COG3848	Pyruvate phosphate dikinase
AKO66_RS03305	COG0574	Belongs to the PEP-utilizing enzyme family
AKO66_RS03310	COG4897	Protein conserved in bacteria
AKO66_RS03325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKO66_RS03340	COG3595	metallopeptidase activity
AKO66_RS03345	COG1983	PspC domain protein
AKO66_RS03350	COG1950	PFAM Membrane protein of
AKO66_RS03355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKO66_RS03360	COG2188	Transcriptional regulator
AKO66_RS03365	COG0363	glucosamine-6-phosphate deaminase activity
AKO66_RS03370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AKO66_RS03375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AKO66_RS03380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKO66_RS03385	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AKO66_RS03390	COG0546	phosphoglycolate phosphatase activity
AKO66_RS03395	COG0110	maltose O-acetyltransferase activity
AKO66_RS03400	COG1959	2 iron, 2 sulfur cluster binding
AKO66_RS03405	COG2910	NAD(P)H-binding
AKO66_RS03415	COG4990	cell redox homeostasis
AKO66_RS03420	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKO66_RS03425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKO66_RS03430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKO66_RS03435	COG0131	Imidazoleglycerol-phosphate dehydratase
AKO66_RS03440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKO66_RS03445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AKO66_RS03450	COG0107	imidazoleglycerol-phosphate synthase activity
AKO66_RS03455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKO66_RS03455	COG0140	phosphoribosyl-ATP diphosphatase activity
AKO66_RS03460	COG0457	Tetratricopeptide repeat
AKO66_RS03465	COG0791	NLP P60 protein
AKO66_RS03465	COG3883	PFAM NLP P60 protein
AKO66_RS03470	COG0492	ferredoxin-NADP+ reductase activity
AKO66_RS03475	COG1051	belongs to the nudix hydrolase family
AKO66_RS03480	COG1660	Displays ATPase and GTPase activities
AKO66_RS03485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AKO66_RS03490	COG1481	regulation of sporulation
AKO66_RS03495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS03500	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AKO66_RS03510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO66_RS03515	COG0288	reversible hydration of carbon dioxide
AKO66_RS03520	COG0659	secondary active sulfate transmembrane transporter activity
AKO66_RS03525	COG1694	Mazg nucleotide pyrophosphohydrolase
AKO66_RS03530	COG1611	Belongs to the LOG family
AKO66_RS03535	COG0740	serine-type endopeptidase activity
AKO66_RS03620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKO66_RS03625	COG0582	viral genome integration into host DNA
AKO66_RS03725	COG5412	phage tail tape measure protein
AKO66_RS03725	COG3953	SLT domain
AKO66_RS03735	COG1388	LysM domain
AKO66_RS03735	COG1705	Flagellar rod assembly protein muramidase FlgJ
AKO66_RS03760	COG4824	toxin secretion phage lysis holin
AKO66_RS03765	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_RS03790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_RS03795	COG1819	glycosyl
AKO66_RS03800	COG0747	negative chemotaxis
AKO66_RS03805	COG0601	transmembrane transport
AKO66_RS03825	COG0488	(ABC) transporter
AKO66_RS03830	COG0726	polysaccharide deacetylase
AKO66_RS03835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_RS03840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_RS03845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_RS03855	COG1396	sequence-specific DNA binding
AKO66_RS03860	COG3944	biosynthesis protein
AKO66_RS03865	COG0489	protein tyrosine kinase activity
AKO66_RS03870	COG1086	Polysaccharide biosynthesis protein
AKO66_RS03875	COG0438	transferase activity, transferring glycosyl groups
AKO66_RS03880	COG1215	transferase activity, transferring glycosyl groups
AKO66_RS03885	COG0438	transferase activity, transferring glycosyl groups
AKO66_RS03895	COG1216	Glycosyl transferase, family 2
AKO66_RS03900	COG5039	Polysaccharide pyruvyl transferase
AKO66_RS03905	COG2244	polysaccharide biosynthetic process
AKO66_RS03910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKO66_RS03915	COG0110	maltose O-acetyltransferase activity
AKO66_RS03920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO66_RS03925	COG0747	negative chemotaxis
AKO66_RS03930	COG0601	transmembrane transport
AKO66_RS03935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO66_RS03940	COG0444	Belongs to the ABC transporter superfamily
AKO66_RS03945	COG4608	Belongs to the ABC transporter superfamily
AKO66_RS03950	COG0534	Mate efflux family protein
AKO66_RS03960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKO66_RS03965	COG2186	Transcriptional regulator
AKO66_RS03970	COG3829	transcription factor binding
AKO66_RS03975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKO66_RS03980	COG0833	amino acid
AKO66_RS03985	COG2390	Transcriptional regulator
AKO66_RS03990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKO66_RS03995	COG0126	phosphoglycerate kinase activity
AKO66_RS04000	COG0149	triose-phosphate isomerase activity
AKO66_RS04005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKO66_RS04010	COG0148	phosphopyruvate hydratase activity
AKO66_RS04020	COG1131	(ABC) transporter
AKO66_RS04040	COG0456	acetyltransferase
AKO66_RS04050	COG2095	MarC family integral membrane protein
AKO66_RS04055	COG1510	regulation of RNA biosynthetic process
AKO66_RS04060	COG1125	glycine betaine transport
AKO66_RS04060	COG0517	IMP dehydrogenase activity
AKO66_RS04065	COG1174	glycine betaine transport
AKO66_RS04070	COG1732	Glycine betaine
AKO66_RS04075	COG1174	glycine betaine transport
AKO66_RS04080	COG1733	regulation of RNA biosynthetic process
AKO66_RS04085	COG1396	sequence-specific DNA binding
AKO66_RS04090	COG1396	sequence-specific DNA binding
AKO66_RS04095	COG1476	TRANSCRIPTIONal
AKO66_RS04100	COG2002	toxin-antitoxin pair type II binding
AKO66_RS04105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKO66_RS04110	COG1647	Serine aminopeptidase, S33
AKO66_RS04115	COG0557	exoribonuclease II activity
AKO66_RS04120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKO66_RS04155	COG1937	Protein conserved in bacteria
AKO66_RS04160	COG2608	mercury ion transmembrane transporter activity
AKO66_RS04165	COG2217	Heavy metal translocating P-type atpase
AKO66_RS04175	COG1027	Aspartate ammonia-lyase
AKO66_RS04180	COG4191	Histidine kinase
AKO66_RS04185	COG0784	Response regulator, receiver
AKO66_RS04190	COG3226	Transcriptional regulator
AKO66_RS04200	COG0803	Belongs to the bacterial solute-binding protein 9 family
AKO66_RS04205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKO66_RS04210	COG1121	(ABC) transporter
AKO66_RS04215	COG2217	Heavy metal translocating P-type atpase
AKO66_RS04220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKO66_RS04225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AKO66_RS04230	COG2860	membrane
AKO66_RS04235	COG0025	NhaP-type Na H and K H
AKO66_RS04240	COG1940	carbohydrate kinase activity
AKO66_RS04245	COG0656	L-ascorbic acid biosynthetic process
AKO66_RS04250	COG4149	molybdate abc transporter
AKO66_RS04255	COG0725	ABC transporter, periplasmic molybdate-binding protein
AKO66_RS04260	COG1368	sulfuric ester hydrolase activity
AKO66_RS04265	COG1988	membrane-bound metal-dependent
AKO66_RS04285	COG0531	amino acid
AKO66_RS04290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_RS04295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_RS04300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_RS04305	COG1120	ATPase activity
AKO66_RS04310	COG0745	RESPONSE REGULATOR receiver
AKO66_RS04315	COG2205	protein histidine kinase activity
AKO66_RS04320	COG1904	glucuronate isomerase
AKO66_RS04325	COG1609	Transcriptional regulator
AKO66_RS04330	COG0246	Mannitol dehydrogenase
AKO66_RS04335	COG2721	sulfolactate sulfo-lyase activity
AKO66_RS04345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_RS04350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_RS04355	COG1120	ATPase activity
AKO66_RS04360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKO66_RS04365	COG1454	alcohol dehydrogenase
AKO66_RS04380	COG3604	Transcriptional regulator
AKO66_RS04390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKO66_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS04400	COG2096	Adenosyltransferase
AKO66_RS04405	COG4758	membrane
AKO66_RS04410	COG1842	Phage shock protein A
AKO66_RS04420	COG4758	membrane
AKO66_RS04425	COG4585	Histidine kinase
AKO66_RS04430	COG2197	response regulator
AKO66_RS04445	COG0814	amino acid
AKO66_RS04450	COG0697	spore germination
AKO66_RS04455	COG0114	fumarate hydratase activity
AKO66_RS04460	COG1309	transcriptional regulator
AKO66_RS04465	COG2205	protein histidine kinase activity
AKO66_RS04465	COG2770	Histidine kinase
AKO66_RS04470	COG0745	RESPONSE REGULATOR receiver
AKO66_RS04475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO66_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS04490	COG1120	ATPase activity
AKO66_RS04500	COG5577	PFAM Coat F domain
AKO66_RS04510	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKO66_RS04510	COG1024	Enoyl-CoA hydratase
AKO66_RS04515	COG0183	Belongs to the thiolase family
AKO66_RS04520	COG1960	acyl-CoA dehydrogenase activity
AKO66_RS04525	COG1393	Belongs to the ArsC family
AKO66_RS04530	COG0509	glycine decarboxylation via glycine cleavage system
AKO66_RS04540	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AKO66_RS04545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_RS04555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AKO66_RS04560	COG2011	ABC-type metal ion transport system permease component
AKO66_RS04565	COG1464	Belongs to the NlpA lipoprotein family
AKO66_RS04570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKO66_RS04575	COG0396	ATPase activity
AKO66_RS04580	COG0719	Fe-S assembly protein
AKO66_RS04585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKO66_RS04590	COG0822	iron-sulfur transferase activity
AKO66_RS04595	COG0719	Fe-S assembly protein
AKO66_RS04610	COG1309	transcriptional regulator
AKO66_RS04620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKO66_RS04635	COG2311	Membrane
AKO66_RS04640	COG0745	RESPONSE REGULATOR receiver
AKO66_RS04645	COG0642	Histidine kinase
AKO66_RS04645	COG5002	protein histidine kinase activity
AKO66_RS04670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_RS04675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_RS04680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_RS04695	COG2356	endonuclease I
AKO66_RS04700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKO66_RS04705	COG2814	Major facilitator Superfamily
AKO66_RS04710	COG2140	Oxalate decarboxylase
AKO66_RS04715	COG2508	Transcriptional regulator
AKO66_RS04720	COG1801	Protein of unknown function DUF72
AKO66_RS04725	COG0737	Belongs to the 5'-nucleotidase family
AKO66_RS04730	COG3377	Domain of unknown function (DUF1805)
AKO66_RS04750	COG0739	heme binding
AKO66_RS04755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKO66_RS04765	COG4470	Protein conserved in bacteria
AKO66_RS04770	COG2445	Protein of unknown function DUF86
AKO66_RS04775	COG0647	UMP catabolic process
AKO66_RS04780	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKO66_RS04785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO66_RS04790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO66_RS04795	COG0460	homoserine dehydrogenase
AKO66_RS04800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AKO66_RS04805	COG0083	homoserine kinase activity
AKO66_RS04810	COG4946	Tricorn protease homolog
AKO66_RS04810	COG0823	Involved in the tonB-independent uptake of proteins
AKO66_RS04810	COG1506	peptidase
AKO66_RS04815	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKO66_RS04820	COG4837	Protein of unknown function (DUF1462)
AKO66_RS04830	COG1252	NADH dehydrogenase
AKO66_RS04835	COG4844	belongs to the
AKO66_RS04840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKO66_RS04845	COG0316	Belongs to the HesB IscA family
AKO66_RS04860	COG0492	ferredoxin-NADP+ reductase activity
AKO66_RS04865	COG1252	NADH dehydrogenase
AKO66_RS04875	COG3584	3D domain protein
AKO66_RS04880	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AKO66_RS04885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKO66_RS04890	COG2056	Na+-H+ antiporter family
AKO66_RS04895	COG1268	BioY protein
AKO66_RS04900	COG0686	Belongs to the AlaDH PNT family
AKO66_RS04905	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AKO66_RS04905	COG2508	Transcriptional regulator
AKO66_RS04910	COG4842	Belongs to the WXG100 family
AKO66_RS04915	COG5417	Belongs to the EsaB family
AKO66_RS04920	COG4499	WXG100 protein secretion system (Wss), protein YukC
AKO66_RS04925	COG0433	COG0433 Predicted ATPase
AKO66_RS04925	COG1674	ftsk spoiiie
AKO66_RS04930	COG1511	domain protein
AKO66_RS04940	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS04945	COG1418	mRNA catabolic process
AKO66_RS04960	COG0628	permease
AKO66_RS04980	COG5506	Protein of unknown function (DUF1694)
AKO66_RS04985	COG1335	isochorismatase
AKO66_RS04990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AKO66_RS04995	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AKO66_RS05010	COG0142	geranyltranstransferase activity
AKO66_RS05020	COG4585	Histidine kinase
AKO66_RS05025	COG2197	response regulator
AKO66_RS05030	COG2050	protein possibly involved in aromatic compounds catabolism
AKO66_RS05035	COG1320	monovalent cation:proton antiporter activity
AKO66_RS05040	COG2212	antiporter activity
AKO66_RS05045	COG1863	multisubunit Na H antiporter MnhE subunit
AKO66_RS05050	COG0651	ATP synthesis coupled electron transport
AKO66_RS05055	COG1006	Multisubunit Na H antiporter MnhC subunit
AKO66_RS05060	COG2111	Na H antiporter
AKO66_RS05065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKO66_RS05065	COG2111	Na H antiporter
AKO66_RS05075	COG3493	citrate carrier protein
AKO66_RS05080	COG1079	Belongs to the binding-protein-dependent transport system permease family
AKO66_RS05085	COG4603	Belongs to the binding-protein-dependent transport system permease family
AKO66_RS05090	COG3845	ABC transporter
AKO66_RS05095	COG1744	ABC transporter substrate-binding protein PnrA-like
AKO66_RS05100	COG4565	transcriptional regulatory protein
AKO66_RS05105	COG3290	protein histidine kinase activity
AKO66_RS05115	COG3011	Protein conserved in bacteria
AKO66_RS05120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO66_RS05125	COG2814	Major facilitator Superfamily
AKO66_RS05130	COG5018	Exonuclease
AKO66_RS05140	COG2205	protein histidine kinase activity
AKO66_RS05145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AKO66_RS05155	COG2267	carboxylic ester hydrolase activity
AKO66_RS05160	COG1522	sequence-specific DNA binding
AKO66_RS05165	COG0436	Aminotransferase
AKO66_RS05170	COG1098	S1 RNA binding domain
AKO66_RS05175	COG2155	Conserved Protein
AKO66_RS05180	COG1979	alcohol dehydrogenase
AKO66_RS05185	COG1979	alcohol dehydrogenase
AKO66_RS05190	COG0166	Belongs to the GPI family
AKO66_RS05205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKO66_RS05215	COG2738	Putative neutral zinc metallopeptidase
AKO66_RS05220	COG1253	flavin adenine dinucleotide binding
AKO66_RS05225	COG0432	Pfam Uncharacterised protein family UPF0047
AKO66_RS05230	COG2070	2-Nitropropane dioxygenase
AKO66_RS05245	COG0840	transmembrane signaling receptor activity
AKO66_RS05250	COG0840	transmembrane signaling receptor activity
AKO66_RS05255	COG0840	transmembrane signaling receptor activity
AKO66_RS05260	COG0840	transmembrane signaling receptor activity
AKO66_RS05265	COG0693	protein deglycase activity
AKO66_RS05270	COG0673	inositol 2-dehydrogenase activity
AKO66_RS05280	COG0628	permease
AKO66_RS05295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKO66_RS05305	COG1396	sequence-specific DNA binding
AKO66_RS05320	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
AKO66_RS05330	COG1595	DNA-templated transcription, initiation
AKO66_RS05335	COG5484	DNA packaging
AKO66_RS05340	COG1783	phage Terminase large subunit
AKO66_RS05345	COG5518	Phage portal protein
AKO66_RS05350	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AKO66_RS05355	COG4653	Phage capsid family
AKO66_RS05400	COG3953	SLT domain
AKO66_RS05400	COG5280	Phage tail tape measure protein TP901
AKO66_RS05400	COG3953	SLT domain
AKO66_RS05400	COG5280	Phage tail tape measure protein TP901
AKO66_RS05405	COG1652	LysM domain
AKO66_RS05410	COG4193	domain, Protein
AKO66_RS05420	COG3628	GPW Gp25 family protein
AKO66_RS05425	COG3299	homolog of phage Mu protein gp47
AKO66_RS05430	COG3778	Protein conserved in bacteria
AKO66_RS05485	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKO66_RS05485	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_RS05500	COG1510	regulation of RNA biosynthetic process
AKO66_RS05505	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_RS05510	COG1454	alcohol dehydrogenase
AKO66_RS05515	COG2318	DinB family
AKO66_RS05520	COG1585	Membrane protein implicated in regulation of membrane protease activity
AKO66_RS05525	COG2268	Band 7 protein
AKO66_RS05530	COG0772	Belongs to the SEDS family
AKO66_RS05535	COG0772	Belongs to the SEDS family
AKO66_RS05540	COG3339	Conserved Protein
AKO66_RS05545	COG1247	-acetyltransferase
AKO66_RS05550	COG3859	Proton-coupled thiamine transporter YuaJ
AKO66_RS05690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO66_RS05695	COG1575	Belongs to the MenA family. Type 1 subfamily
AKO66_RS05700	COG1169	isochorismate synthase
AKO66_RS05705	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AKO66_RS05710	COG0596	Alpha beta hydrolase
AKO66_RS05715	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AKO66_RS05720	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_RS05725	COG4948	Mandelate Racemase Muconate Lactonizing
AKO66_RS05740	COG1294	oxidase, subunit
AKO66_RS05745	COG1271	oxidase subunit
AKO66_RS05755	COG3443	Belongs to the bacterial solute-binding protein 9 family
AKO66_RS05755	COG0803	Belongs to the bacterial solute-binding protein 9 family
AKO66_RS05760	COG0288	reversible hydration of carbon dioxide
AKO66_RS05765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKO66_RS05770	COG1854	S-ribosylhomocysteine lyase activity
AKO66_RS05785	COG0783	Belongs to the Dps family
AKO66_RS05795	COG4824	toxin secretion phage lysis holin
AKO66_RS05810	COG2310	stress, protein
AKO66_RS05815	COG0494	nUDIX hydrolase
AKO66_RS05820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKO66_RS05825	COG1116	anion transmembrane transporter activity
AKO66_RS05830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKO66_RS05850	COG1233	COG1233 Phytoene dehydrogenase and related
AKO66_RS05855	COG1506	peptidase
AKO66_RS05865	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKO66_RS05870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKO66_RS05875	COG0367	asparagine synthase
AKO66_RS05880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKO66_RS05885	COG2267	carboxylic ester hydrolase activity
AKO66_RS05895	COG4326	sporulation control protein
AKO66_RS05900	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AKO66_RS05905	COG1242	4 iron, 4 sulfur cluster binding
AKO66_RS05925	COG1725	Transcriptional regulator
AKO66_RS05930	COG1131	(ABC) transporter
AKO66_RS05940	COG1136	(ABC) transporter
AKO66_RS05945	COG0577	efflux transmembrane transporter activity
AKO66_RS05950	COG2433	Pfam Transposase IS66
AKO66_RS05955	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_RS05955	COG2202	Pas domain
AKO66_RS05965	COG0495	leucyl-tRNA aminoacylation
AKO66_RS05970	COG1073	alpha beta
AKO66_RS05975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO66_RS05980	COG0395	ABC-type sugar transport system, permease component
AKO66_RS05985	COG1653	transport
AKO66_RS05990	COG0656	L-ascorbic acid biosynthetic process
AKO66_RS05995	COG2814	Major facilitator Superfamily
AKO66_RS06000	COG1733	regulation of RNA biosynthetic process
AKO66_RS06005	COG2207	Transcriptional regulator
AKO66_RS06010	COG4209	transmembrane transport
AKO66_RS06015	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AKO66_RS06020	COG1653	transport
AKO66_RS06025	COG0673	inositol 2-dehydrogenase activity
AKO66_RS06030	COG5578	integral membrane protein
AKO66_RS06035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO66_RS06045	COG3196	Protein conserved in bacteria
AKO66_RS06050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKO66_RS06060	COG2081	HI0933 family
AKO66_RS06065	COG2244	polysaccharide biosynthetic process
AKO66_RS06070	COG1187	pseudouridine synthase activity
AKO66_RS06075	COG1349	DNA-binding transcription factor activity
AKO66_RS06080	COG2252	PERMEase
AKO66_RS06085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKO66_RS06090	COG3340	Belongs to the peptidase S51 family
AKO66_RS06095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO66_RS06100	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKO66_RS06110	COG1597	lipid kinase activity
AKO66_RS06115	COG0510	thiamine kinase activity
AKO66_RS06125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKO66_RS06130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_RS06135	COG0281	malic enzyme
AKO66_RS06140	COG5584	Small secreted protein
AKO66_RS06145	COG1363	Peptidase, m42
AKO66_RS06160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_RS06165	COG4848	Belongs to the UPF0354 family
AKO66_RS06170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_RS06175	COG1674	ftsk spoiiie
AKO66_RS06180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKO66_RS06185	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AKO66_RS06190	COG4980	gas vesicle protein
AKO66_RS06195	COG3118	belongs to the thioredoxin family
AKO66_RS06200	COG1605	Chorismate mutase
AKO66_RS06200	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AKO66_RS06205	COG1609	Transcriptional regulator
AKO66_RS06210	COG0123	including yeast histone deacetylase and acetoin utilization protein
AKO66_RS06215	COG0517	IMP dehydrogenase activity
AKO66_RS06220	COG0454	-acetyltransferase
AKO66_RS06225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO66_RS06230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKO66_RS06235	COG2329	Antibiotic biosynthesis monooxygenase
AKO66_RS06240	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AKO66_RS06250	COG1335	isochorismatase
AKO66_RS06260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKO66_RS06265	COG1956	GAF domain-containing protein
AKO66_RS06270	COG1309	transcriptional regulator
AKO66_RS06275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO66_RS06280	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AKO66_RS06285	COG1114	Component of the transport system for branched-chain amino acids
AKO66_RS06290	COG1114	Component of the transport system for branched-chain amino acids
AKO66_RS06295	COG1104	cysteine desulfurase activity
AKO66_RS06300	COG0301	tRNA thio-modification
AKO66_RS06310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO66_RS06315	COG1279	arginine transmembrane transporter activity
AKO66_RS06330	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKO66_RS06335	COG0402	S-adenosylhomocysteine deaminase activity
AKO66_RS06340	COG0577	efflux transmembrane transporter activity
AKO66_RS06345	COG1136	(ABC) transporter
AKO66_RS06350	COG1695	Transcriptional regulator
AKO66_RS06355	COG0772	Belongs to the SEDS family
AKO66_RS06360	COG2205	protein histidine kinase activity
AKO66_RS06365	COG0745	RESPONSE REGULATOR receiver
AKO66_RS06370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_RS06375	COG2197	response regulator
AKO66_RS06380	COG4585	Histidine kinase
AKO66_RS06385	COG3239	Fatty acid desaturase
AKO66_RS06395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKO66_RS06400	COG0616	signal peptide processing
AKO66_RS06405	COG1714	RDD family
AKO66_RS06415	COG3874	Sporulation protein YtfJ
AKO66_RS06420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AKO66_RS06425	COG0827	DNA restriction-modification system
AKO66_RS06430	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKO66_RS06435	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKO66_RS06440	COG0137	argininosuccinate synthase activity
AKO66_RS06445	COG0165	Argininosuccinate lyase
AKO66_RS06455	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS06460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKO66_RS06465	COG4109	DRTGG domain
AKO66_RS06475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKO66_RS06495	COG0587	DNA-directed DNA polymerase activity
AKO66_RS06500	COG0281	malic enzyme
AKO66_RS06505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKO66_RS06510	COG0825	malonyl-CoA metabolic process
AKO66_RS06515	COG0205	6-phosphofructokinase activity
AKO66_RS06525	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKO66_RS06530	COG0628	permease
AKO66_RS06535	COG2707	UPF0756 membrane protein
AKO66_RS06540	COG0372	Belongs to the citrate synthase family
AKO66_RS06545	COG0538	isocitrate dehydrogenase activity
AKO66_RS06550	COG0039	L-malate dehydrogenase activity
AKO66_RS06555	COG0745	RESPONSE REGULATOR receiver
AKO66_RS06560	COG5002	protein histidine kinase activity
AKO66_RS06565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO66_RS06565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO66_RS06570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKO66_RS06575	COG1971	Probably functions as a manganese efflux pump
AKO66_RS06580	COG0237	dephospho-CoA kinase activity
AKO66_RS06585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKO66_RS06590	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKO66_RS06600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKO66_RS06605	COG3611	Membrane attachment protein
AKO66_RS06610	COG1484	DNA-dependent DNA replication
AKO66_RS06615	COG0398	Pfam SNARE associated Golgi protein
AKO66_RS06625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKO66_RS06635	COG1011	Hydrolase
AKO66_RS06645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AKO66_RS06650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKO66_RS06655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKO66_RS06660	COG3326	Membrane
AKO66_RS06670	COG1363	Peptidase, m42
AKO66_RS06675	COG1966	Carbon starvation protein
AKO66_RS06685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKO66_RS06690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKO66_RS06695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_RS06695	COG0072	phenylalanine-tRNA ligase activity
AKO66_RS06700	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKO66_RS06705	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AKO66_RS06710	COG1286	toxin biosynthetic process
AKO66_RS06715	COG1796	DNA polymerase
AKO66_RS06715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO66_RS06720	COG1193	negative regulation of DNA recombination
AKO66_RS06725	COG3766	membrane
AKO66_RS06735	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_RS06740	COG1309	transcriptional regulator
AKO66_RS06745	COG1024	Enoyl-CoA hydratase
AKO66_RS06750	COG2086	electron transfer activity
AKO66_RS06755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AKO66_RS06760	COG3534	alpha-L-arabinofuranosidase
AKO66_RS06765	COG3118	belongs to the thioredoxin family
AKO66_RS06770	COG0322	excinuclease ABC activity
AKO66_RS06775	COG0527	aspartate kinase activity
AKO66_RS06780	COG1719	4-vinyl reductase, 4VR
AKO66_RS06785	COG2009	succinate dehydrogenase
AKO66_RS06790	COG1053	succinate dehydrogenase
AKO66_RS06795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKO66_RS06800	COG0824	Thioesterase
AKO66_RS06805	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKO66_RS06805	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKO66_RS06810	COG2828	Protein conserved in bacteria
AKO66_RS06815	COG0583	DNA-binding transcription factor activity
AKO66_RS06820	COG2851	Citrate transporter
AKO66_RS06825	COG2197	response regulator
AKO66_RS06830	COG1846	Transcriptional regulator
AKO66_RS06835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKO66_RS06840	COG5401	PFAM Sporulation and spore germination
AKO66_RS06845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKO66_RS06850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKO66_RS06855	COG0622	Phosphoesterase
AKO66_RS06895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO66_RS06900	COG1696	Membrane protein involved in D-alanine export
AKO66_RS06905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO66_RS06910	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AKO66_RS06915	COG3339	Conserved Protein
AKO66_RS06920	COG2706	6-phosphogluconolactonase activity
AKO66_RS06925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO66_RS06930	COG0028	Belongs to the TPP enzyme family
AKO66_RS06935	COG0440	acetolactate synthase activity
AKO66_RS06940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AKO66_RS06945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO66_RS06950	COG0473	3-isopropylmalate dehydrogenase activity
AKO66_RS06955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKO66_RS06960	COG0066	3-isopropylmalate dehydratase activity
AKO66_RS06965	COG1477	protein flavinylation
AKO66_RS06965	COG0457	Tetratricopeptide repeat
AKO66_RS06970	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKO66_RS06975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKO66_RS06980	COG0470	DNA polymerase III
AKO66_RS06980	COG1067	ATP-dependent peptidase activity
AKO66_RS06985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKO66_RS06990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AKO66_RS07010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKO66_RS07015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKO66_RS07020	COG0181	hydroxymethylbilane synthase activity
AKO66_RS07025	COG1587	Uroporphyrinogen-III synthase
AKO66_RS07030	COG0113	porphobilinogen synthase activity
AKO66_RS07035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKO66_RS07040	COG1388	LysM domain
AKO66_RS07045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO66_RS07055	COG0525	valine-tRNA ligase activity
AKO66_RS07060	COG0285	dihydrofolate synthase activity
AKO66_RS07065	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKO66_RS07075	COG0424	maF-like protein
AKO66_RS07080	COG2003	Belongs to the UPF0758 family
AKO66_RS07085	COG1077	Cell shape determining protein MreB Mrl
AKO66_RS07095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AKO66_RS07100	COG0850	regulation of cytokinetic process
AKO66_RS07105	COG2894	cell division
AKO66_RS07110	COG0739	heme binding
AKO66_RS07115	COG1994	Peptidase M50
AKO66_RS07120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKO66_RS07125	COG2868	ribosomal protein
AKO66_RS07130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKO66_RS07135	COG3290	protein histidine kinase activity
AKO66_RS07140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKO66_RS07145	COG4492	Belongs to the UPF0735 family
AKO66_RS07150	COG0077	Prephenate dehydratase
AKO66_RS07155	COG1827	regulation of RNA biosynthetic process
AKO66_RS07160	COG1104	cysteine desulfurase activity
AKO66_RS07165	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AKO66_RS07170	COG0157	Belongs to the NadC ModD family
AKO66_RS07175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKO66_RS07180	COG1388	LysM domain
AKO66_RS07195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKO66_RS07205	COG2112	serine threonine protein kinase
AKO66_RS07215	COG0632	four-way junction helicase activity
AKO66_RS07220	COG2255	four-way junction helicase activity
AKO66_RS07230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKO66_RS07235	COG0343	queuine tRNA-ribosyltransferase activity
AKO66_RS07240	COG1862	Preprotein translocase
AKO66_RS07250	COG2323	membrane
AKO66_RS07255	COG2244	polysaccharide biosynthetic process
AKO66_RS07265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKO66_RS07265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKO66_RS07270	COG0490	domain, Protein
AKO66_RS07275	COG5416	Lipopolysaccharide assembly protein A domain
AKO66_RS07280	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AKO66_RS07280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKO66_RS07285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO66_RS07290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKO66_RS07295	COG1490	D-aminoacyl-tRNA deacylase activity
AKO66_RS07300	COG4991	sh3 domain protein
AKO66_RS07300	COG3103	Sh3 type 3 domain protein
AKO66_RS07300	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_RS07305	COG0124	histidyl-tRNA synthetase
AKO66_RS07320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKO66_RS07325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKO66_RS07330	COG1959	2 iron, 2 sulfur cluster binding
AKO66_RS07335	COG1104	cysteine desulfurase activity
AKO66_RS07340	COG0482	sulfurtransferase activity
AKO66_RS07345	COG0457	Tetratricopeptide repeat
AKO66_RS07350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKO66_RS07355	COG3881	PFAM PRC-barrel domain
AKO66_RS07370	COG0765	amino acid transport
AKO66_RS07375	COG0765	amino acid transport
AKO66_RS07380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_RS07385	COG1126	abc transporter atp-binding protein
AKO66_RS07390	COG0628	permease
AKO66_RS07395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKO66_RS07400	COG4472	Bacterial protein of unknown function (DUF965)
AKO66_RS07405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKO66_RS07410	COG3906	Belongs to the UPF0473 family
AKO66_RS07420	COG1268	BioY protein
AKO66_RS07425	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_RS07430	COG0183	Belongs to the thiolase family
AKO66_RS07435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKO66_RS07440	COG4122	O-methyltransferase activity
AKO66_RS07445	COG0826	peptidase U32
AKO66_RS07450	COG0826	peptidase U32
AKO66_RS07455	COG0572	uridine kinase
AKO66_RS07460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKO66_RS07465	COG0768	penicillin binding
AKO66_RS07480	COG2226	methyltransferase
AKO66_RS07485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKO66_RS07490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO66_RS07495	COG0626	cystathionine gamma-synthase activity
AKO66_RS07510	COG2226	methyltransferase
AKO66_RS07515	COG1063	alcohol dehydrogenase
AKO66_RS07520	COG0583	DNA-binding transcription factor activity
AKO66_RS07525	COG1115	amino acid carrier protein
AKO66_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS07545	COG1063	alcohol dehydrogenase
AKO66_RS07555	COG0765	amino acid transport
AKO66_RS07560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_RS07565	COG1126	abc transporter atp-binding protein
AKO66_RS07570	COG1960	acyl-CoA dehydrogenase activity
AKO66_RS07575	COG2602	Beta-lactamase
AKO66_RS07600	COG0657	acetylesterase activity
AKO66_RS07605	COG1733	regulation of RNA biosynthetic process
AKO66_RS07610	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AKO66_RS07615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AKO66_RS07625	COG1846	Transcriptional regulator
AKO66_RS07635	COG1609	Transcriptional regulator
AKO66_RS07650	COG2160	L-arabinose isomerase activity
AKO66_RS07675	COG1122	ATPase activity
AKO66_RS07710	COG0726	polysaccharide deacetylase
AKO66_RS07740	COG0457	Tetratricopeptide repeat
AKO66_RS07750	COG2755	lipolytic protein G-D-S-L family
AKO66_RS07760	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AKO66_RS07765	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AKO66_RS07770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKO66_RS07775	COG1534	Rna-binding protein
AKO66_RS07780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKO66_RS07785	COG1713	HD superfamily hydrolase involved in NAD metabolism
AKO66_RS07790	COG0799	negative regulation of ribosome biogenesis
AKO66_RS07795	COG2226	methyltransferase
AKO66_RS07800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO66_RS07805	COG1596	polysaccharide export
AKO66_RS07805	COG1555	photosystem II stabilization
AKO66_RS07810	COG2131	deaminase
AKO66_RS07815	COG0658	competence protein
AKO66_RS07815	COG2333	competence protein COMEC
AKO66_RS07825	COG1466	dna polymerase III delta subunit
AKO66_RS07830	COG0268	Binds directly to 16S ribosomal RNA
AKO66_RS07835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AKO66_RS07840	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_RS07850	COG0481	GTPase activity
AKO66_RS07855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKO66_RS07860	COG1420	regulation of RNA biosynthetic process
AKO66_RS07865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKO66_RS07870	COG0443	Heat shock 70 kDa protein
AKO66_RS07875	COG0484	heat shock protein binding
AKO66_RS07880	COG2264	protein methyltransferase activity
AKO66_RS07885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKO66_RS07890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKO66_RS07895	COG1283	sodium-dependent phosphate transmembrane transporter activity
AKO66_RS07905	COG1610	YqeY-like protein
AKO66_RS07910	COG1030	water channel activity
AKO66_RS07915	COG4864	UPF0365 protein
AKO66_RS07930	COG0561	phosphatase activity
AKO66_RS07935	COG1702	phosphate starvation-inducible protein PhoH
AKO66_RS07940	COG1480	7TM receptor with intracellular HD hydrolase
AKO66_RS07945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKO66_RS07950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AKO66_RS07955	COG0295	cytidine deaminase activity
AKO66_RS07960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKO66_RS07970	COG1381	Involved in DNA repair and RecF pathway recombination
AKO66_RS07975	COG0752	glycyl-tRNA synthetase alpha subunit
AKO66_RS07980	COG0751	glycine-tRNA ligase activity
AKO66_RS07985	COG0517	IMP dehydrogenase activity
AKO66_RS07990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKO66_RS07995	COG1671	Belongs to the UPF0178 family
AKO66_RS08000	COG0358	DNA primase activity
AKO66_RS08005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKO66_RS08010	COG2010	Cytochrome c
AKO66_RS08015	COG2384	SAM-dependent methyltransferase
AKO66_RS08020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKO66_RS08025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKO66_RS08035	COG0513	Belongs to the DEAD box helicase family
AKO66_RS08050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_RS08055	COG1121	(ABC) transporter
AKO66_RS08060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKO66_RS08065	COG0735	belongs to the Fur family
AKO66_RS08070	COG1940	carbohydrate kinase activity
AKO66_RS08075	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AKO66_RS08080	COG4709	membrane
AKO66_RS08085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKO66_RS08090	COG1388	LysM domain
AKO66_RS08095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO66_RS08100	COG5521	maltodextrose utilization protein MalA
AKO66_RS08105	COG2839	Protein conserved in bacteria
AKO66_RS08110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKO66_RS08115	COG0477	Major facilitator Superfamily
AKO66_RS08120	COG0768	penicillin binding
AKO66_RS08125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AKO66_RS08130	COG0573	inorganic phosphate transmembrane transporter activity
AKO66_RS08135	COG0581	inorganic phosphate transmembrane transporter activity
AKO66_RS08140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKO66_RS08145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKO66_RS08150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKO66_RS08165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKO66_RS08170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKO66_RS08180	COG0457	Tetratricopeptide repeat
AKO66_RS08180	COG0705	Rhomboid family
AKO66_RS08185	COG4483	Protein conserved in bacteria
AKO66_RS08190	COG1940	carbohydrate kinase activity
AKO66_RS08195	COG1368	sulfuric ester hydrolase activity
AKO66_RS08200	COG2866	Carboxypeptidase
AKO66_RS08205	COG2814	Major facilitator Superfamily
AKO66_RS08210	COG0011	TIGRFAM Protein of
AKO66_RS08220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_RS08230	COG1393	Belongs to the ArsC family
AKO66_RS08240	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_RS08245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKO66_RS08250	COG1459	type II secretion system
AKO66_RS08255	COG4537	Required for transformation and DNA binding
AKO66_RS08260	COG4970	Tfp pilus assembly protein FimT
AKO66_RS08295	COG0681	Belongs to the peptidase S26 family
AKO66_RS08315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKO66_RS08320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKO66_RS08325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKO66_RS08330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKO66_RS08335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO66_RS08340	COG0095	Lipoate-protein ligase
AKO66_RS08345	COG1321	iron dependent repressor
AKO66_RS08350	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKO66_RS08360	COG3872	metal-dependent enzyme
AKO66_RS08370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKO66_RS08375	COG0006	proline dipeptidase activity
AKO66_RS08380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKO66_RS08390	COG3854	ATPases associated with a variety of cellular activities
AKO66_RS08430	COG0511	ligase activity, forming carbon-carbon bonds
AKO66_RS08435	COG0439	Biotin carboxylase
AKO66_RS08440	COG1302	Protein conserved in bacteria
AKO66_RS08445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKO66_RS08450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKO66_RS08455	COG1570	exodeoxyribonuclease VII activity
AKO66_RS08460	COG1722	exodeoxyribonuclease VII activity
AKO66_RS08465	COG0142	geranyltranstransferase activity
AKO66_RS08470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKO66_RS08475	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AKO66_RS08480	COG1438	arginine binding
AKO66_RS08485	COG0497	DNA recombination
AKO66_RS08490	COG0750	zinc metalloprotease
AKO66_RS08495	COG0745	RESPONSE REGULATOR receiver
AKO66_RS08500	COG0457	Tetratricopeptide repeat
AKO66_RS08505	COG0584	glycerophosphoryl diester phosphodiesterase
AKO66_RS08515	COG3829	transcription factor binding
AKO66_RS08515	COG3290	protein histidine kinase activity
AKO66_RS08520	COG0280	phosphate acetyltransferase
AKO66_RS08530	COG3426	butyrate kinase activity
AKO66_RS08535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO66_RS08540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO66_RS08545	COG0022	dehydrogenase e1 component
AKO66_RS08550	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_RS08560	COG1597	lipid kinase activity
AKO66_RS08570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_RS08575	COG0765	amino acid transport
AKO66_RS08580	COG1126	abc transporter atp-binding protein
AKO66_RS08585	COG4129	membrane
AKO66_RS08590	COG1376	ErfK ybiS ycfS ynhG family protein
AKO66_RS08595	COG0346	lactoylglutathione lyase activity
AKO66_RS08600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKO66_RS08605	COG2195	Cleaves the N-terminal amino acid of tripeptides
AKO66_RS08610	COG0835	chemotaxis
AKO66_RS08615	COG0706	membrane insertase activity
AKO66_RS08625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKO66_RS08630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AKO66_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS08650	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_RS08655	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO66_RS08660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_RS08665	COG2723	6-phospho-beta-galactosidase activity
AKO66_RS08670	COG2188	Transcriptional regulator
AKO66_RS08675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKO66_RS08685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_RS08690	COG0596	Alpha beta hydrolase
AKO66_RS08695	COG1902	pentaerythritol trinitrate reductase activity
AKO66_RS08700	COG4187	Peptidase family M20/M25/M40
AKO66_RS08710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO66_RS08715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_RS08720	COG0300	oxidoreductase activity
AKO66_RS08730	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKO66_RS08735	COG1072	(Pantothenic acid kinase))
AKO66_RS08740	COG2211	Major facilitator Superfamily
AKO66_RS08750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKO66_RS08760	COG0456	acetyltransferase
AKO66_RS08765	COG0456	acetyltransferase
AKO66_RS08765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKO66_RS08770	COG4305	rare lipoprotein A
AKO66_RS08775	COG4918	Iron-sulphur cluster biosynthesis
AKO66_RS08785	COG0457	Tetratricopeptide repeat
AKO66_RS08790	COG1073	alpha beta
AKO66_RS08805	COG0667	Aldo Keto reductase
AKO66_RS08810	COG0494	nUDIX hydrolase
AKO66_RS08815	COG1379	DNA repair
AKO66_RS08820	COG2153	protein acetylation
AKO66_RS08830	COG1404	Belongs to the peptidase S8 family
AKO66_RS08835	COG1300	Membrane
AKO66_RS08840	COG0735	belongs to the Fur family
AKO66_RS08850	COG4974	Belongs to the 'phage' integrase family
AKO66_RS08855	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AKO66_RS08860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AKO66_RS08865	COG1686	Belongs to the peptidase S11 family
AKO66_RS08875	COG2172	sigma factor antagonist activity
AKO66_RS08880	COG1191	sigma factor activity
AKO66_RS08900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKO66_RS08915	COG0697	spore germination
AKO66_RS08920	COG0019	diaminopimelate decarboxylase activity
AKO66_RS08925	COG4086	secreted protein
AKO66_RS08930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKO66_RS08935	COG2814	Major facilitator Superfamily
AKO66_RS08955	COG0307	riboflavin synthase, alpha
AKO66_RS08965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKO66_RS08970	COG0456	acetyltransferase
AKO66_RS08975	COG1547	Domain of unknown function (DUF309)
AKO66_RS08980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKO66_RS08985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKO66_RS08995	COG1686	Belongs to the peptidase S11 family
AKO66_RS09000	COG2715	membrane protein required for spore maturation
AKO66_RS09005	COG0700	Nucleoside recognition
AKO66_RS09010	COG1187	pseudouridine synthase activity
AKO66_RS09015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_RS09020	COG1333	cytochrome c biogenesis protein
AKO66_RS09025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKO66_RS09030	COG0745	RESPONSE REGULATOR receiver
AKO66_RS09035	COG5002	protein histidine kinase activity
AKO66_RS09040	COG1595	DNA-templated transcription, initiation
AKO66_RS09055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKO66_RS09060	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AKO66_RS09065	COG1141	Ferredoxin
AKO66_RS09070	COG4955	Helix-turn-helix domain
AKO66_RS09075	COG0514	ATP-dependent DNA helicase (RecQ)
AKO66_RS09080	COG1266	CAAX protease self-immunity
AKO66_RS09085	COG1388	LysM domain
AKO66_RS09095	COG1408	metallophosphoesterase
AKO66_RS09100	COG4862	establishment of competence for transformation
AKO66_RS09105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKO66_RS09110	COG0492	ferredoxin-NADP+ reductase activity
AKO66_RS09115	COG2339	peptidase activity
AKO66_RS09120	COG3773	Cell wall hydrolase
AKO66_RS09120	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_RS09125	COG2959	enzyme of heme biosynthesis
AKO66_RS09130	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AKO66_RS09140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKO66_RS09145	COG0539	negative regulation of cytoplasmic translation
AKO66_RS09150	COG1304	FMN binding
AKO66_RS09175	COG1160	GTP binding
AKO66_RS09180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKO66_RS09195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKO66_RS09200	COG0776	regulation of translation
AKO66_RS09205	COG0302	gtp cyclohydrolase
AKO66_RS09215	COG0142	geranyltranstransferase activity
AKO66_RS09220	COG2226	methyltransferase
AKO66_RS09225	COG0142	geranyltranstransferase activity
AKO66_RS09230	COG0105	UTP biosynthetic process
AKO66_RS09235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AKO66_RS09240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKO66_RS09245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKO66_RS09250	COG4401	Chorismate mutase type I
AKO66_RS09260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKO66_RS09265	COG0134	indole-3-glycerol-phosphate synthase activity
AKO66_RS09270	COG0135	phosphoribosylanthranilate isomerase activity
AKO66_RS09275	COG0133	tryptophan synthase activity
AKO66_RS09280	COG0159	tryptophan synthase activity
AKO66_RS09285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKO66_RS09290	COG0287	Prephenate dehydrogenase
AKO66_RS09295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKO66_RS09300	COG0457	Tetratricopeptide repeat
AKO66_RS09305	COG5582	Belongs to the UPF0302 family
AKO66_RS09315	COG0723	plastoquinol--plastocyanin reductase activity
AKO66_RS09320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKO66_RS09325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKO66_RS09325	COG2010	Cytochrome c
AKO66_RS09330	COG4347	Protein of unknown function (DUF1405)
AKO66_RS09340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_RS09345	COG1694	Mazg nucleotide pyrophosphohydrolase
AKO66_RS09350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKO66_RS09355	COG1803	Methylglyoxal synthase
AKO66_RS09360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO66_RS09365	COG0438	transferase activity, transferring glycosyl groups
AKO66_RS09370	COG0617	tRNA 3'-terminal CCA addition
AKO66_RS09380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKO66_RS09385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKO66_RS09390	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AKO66_RS09395	COG1199	ATP-dependent helicase activity
AKO66_RS09395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKO66_RS09405	COG5353	protein conserved in bacteria
AKO66_RS09410	COG0017	Asparaginyl-tRNA synthetase
AKO66_RS09415	COG3935	DnaD domain protein
AKO66_RS09420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKO66_RS09430	COG4499	WXG100 protein secretion system (Wss), protein YukC
AKO66_RS09430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO66_RS09435	COG3331	DNA recombination
AKO66_RS09465	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO66_RS09470	COG2190	(PTS) system
AKO66_RS09475	COG1902	pentaerythritol trinitrate reductase activity
AKO66_RS09480	COG1111	helicase
AKO66_RS09480	COG1205	dead DEAH box helicase
AKO66_RS09490	COG3620	sequence-specific DNA binding
AKO66_RS09580	COG1802	Transcriptional regulator
AKO66_RS09580	COG4626	Terminase
AKO66_RS09660	COG3942	CHAP domain
AKO66_RS09660	COG1705	Flagellar rod assembly protein muramidase FlgJ
AKO66_RS09685	COG4824	toxin secretion phage lysis holin
AKO66_RS09690	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_RS09710	COG0457	Tetratricopeptide repeat
AKO66_RS09725	COG1111	helicase
AKO66_RS09725	COG1205	dead DEAH box helicase
AKO66_RS09730	COG3359	exonuclease
AKO66_RS09735	COG4474	Belongs to the UPF0398 family
AKO66_RS09740	COG3599	regulation of cell shape
AKO66_RS09750	COG0116	Belongs to the methyltransferase superfamily
AKO66_RS09760	COG1199	ATP-dependent helicase activity
AKO66_RS09765	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AKO66_RS09770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO66_RS09775	COG2233	PERMEase
AKO66_RS09780	COG0726	polysaccharide deacetylase
AKO66_RS09785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKO66_RS09785	COG0456	acetyltransferase
AKO66_RS09790	COG3424	synthase
AKO66_RS09795	COG1755	Isoprenylcysteine carboxyl methyltransferase
AKO66_RS09800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKO66_RS09810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO66_RS09820	COG0328	RNA-DNA hybrid ribonuclease activity
AKO66_RS09825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKO66_RS09830	COG0328	RNA-DNA hybrid ribonuclease activity
AKO66_RS09845	COG1278	Cold shock
AKO66_RS09855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKO66_RS09860	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AKO66_RS09865	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AKO66_RS09870	COG0386	Belongs to the glutathione peroxidase family
AKO66_RS09875	COG1418	mRNA catabolic process
AKO66_RS09880	COG1413	lyase activity
AKO66_RS09885	COG0129	dihydroxy-acid dehydratase activity
AKO66_RS09895	COG2136	Putative SAM-dependent methyltransferase
AKO66_RS09895	COG2521	methyltransferase
AKO66_RS09905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKO66_RS09910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKO66_RS09915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AKO66_RS09920	COG0204	Acyl-transferase
AKO66_RS09925	COG1272	protein, Hemolysin III
AKO66_RS09930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AKO66_RS09935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKO66_RS09950	COG1999	signal sequence binding
AKO66_RS09955	COG2755	lipolytic protein G-D-S-L family
AKO66_RS09960	COG4698	Protein conserved in bacteria
AKO66_RS09980	COG1846	Transcriptional regulator
AKO66_RS09985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKO66_RS09990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKO66_RS09995	COG1086	Polysaccharide biosynthesis protein
AKO66_RS10005	COG4641	Protein conserved in bacteria
AKO66_RS10020	COG0463	Glycosyl transferase, family 2
AKO66_RS10025	COG3829	transcription factor binding
AKO66_RS10030	COG1509	lysine 2,3-aminomutase activity
AKO66_RS10040	COG4479	Belongs to the UPF0346 family
AKO66_RS10055	COG0671	phosphoesterase, PA-phosphatase related
AKO66_RS10065	COG0813	purine-nucleoside phosphorylase activity
AKO66_RS10070	COG1876	peptidase activity
AKO66_RS10080	COG2226	methyltransferase
AKO66_RS10085	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_RS10085	COG0793	Belongs to the peptidase S41A family
AKO66_RS10090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO66_RS10100	COG0778	Nitroreductase
AKO66_RS10105	COG1733	regulation of RNA biosynthetic process
AKO66_RS10120	COG2962	Rard protein
AKO66_RS10130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO66_RS10135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO66_RS10140	COG0534	Mate efflux family protein
AKO66_RS10145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKO66_RS10150	COG1388	LysM domain
AKO66_RS10150	COG0791	NLP P60 protein
AKO66_RS10155	COG2032	superoxide dismutase activity
AKO66_RS10160	COG0714	Associated with various cellular activities
AKO66_RS10165	COG4548	von Willebrand factor, type A
AKO66_RS10170	COG0567	Dehydrogenase, E1 component
AKO66_RS10175	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_RS10180	COG0385	Bile acid
AKO66_RS10185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKO66_RS10190	COG1657	PFAM Prenyltransferase squalene oxidase
AKO66_RS10200	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_RS10220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO66_RS10230	COG0514	ATP-dependent DNA helicase (RecQ)
AKO66_RS10235	COG1388	LysM domain
AKO66_RS10235	COG3584	3D domain protein
AKO66_RS10245	COG2322	membrane
AKO66_RS10250	COG0372	Belongs to the citrate synthase family
AKO66_RS10255	COG2079	MmgE PrpD family protein
AKO66_RS10260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AKO66_RS10265	COG0741	lytic transglycosylase activity
AKO66_RS10270	COG0531	amino acid
AKO66_RS10275	COG0640	Transcriptional regulator
AKO66_RS10285	COG2378	regulation of single-species biofilm formation
AKO66_RS10290	COG3708	Transcriptional regulator
AKO66_RS10295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_RS10300	COG1309	transcriptional regulator
AKO66_RS10320	COG1994	Peptidase M50
AKO66_RS10325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_RS10330	COG2211	Major facilitator Superfamily
AKO66_RS10340	COG1940	carbohydrate kinase activity
AKO66_RS10345	COG2115	Belongs to the xylose isomerase family
AKO66_RS10350	COG1070	Carbohydrate kinase
AKO66_RS10360	COG0243	molybdopterin cofactor binding
AKO66_RS10370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO66_RS10375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKO66_RS10380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKO66_RS10385	COG0454	-acetyltransferase
AKO66_RS10390	COG4978	Transcriptional regulator
AKO66_RS10390	COG0789	Transcriptional regulator
AKO66_RS10395	COG1132	(ABC) transporter
AKO66_RS10405	COG0583	DNA-binding transcription factor activity
AKO66_RS10410	COG0069	glutamate synthase activity
AKO66_RS10410	COG0067	glutamate synthase
AKO66_RS10410	COG0070	glutamate synthase
AKO66_RS10415	COG0493	'glutamate synthase
AKO66_RS10420	COG2223	nitrite transmembrane transporter activity
AKO66_RS10425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO66_RS10430	COG0243	molybdopterin cofactor binding
AKO66_RS10435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO66_RS10440	COG2146	nitrite reductase [NAD(P)H] activity
AKO66_RS10445	COG2323	membrane
AKO66_RS10450	COG4677	pectinesterase activity
AKO66_RS10455	COG2027	D-alanyl-D-alanine carboxypeptidase
AKO66_RS10460	COG0534	Mate efflux family protein
AKO66_RS10475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO66_RS10485	COG1587	Uroporphyrinogen-III synthase
AKO66_RS10490	COG0586	Pfam SNARE associated Golgi protein
AKO66_RS10495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKO66_RS10500	COG2246	polysaccharide biosynthetic process
AKO66_RS10505	COG0166	Belongs to the GPI family
AKO66_RS10525	COG0247	lactate metabolic process
AKO66_RS10530	COG0277	FAD linked oxidase domain protein
AKO66_RS10535	COG3835	regulator
AKO66_RS10545	COG1942	4-Oxalocrotonate Tautomerase
AKO66_RS10550	COG1349	DNA-binding transcription factor activity
AKO66_RS10555	COG2365	Tyrosine phosphatase family
AKO66_RS10560	COG1649	PFAM Uncharacterised BCR, COG1649
AKO66_RS10565	COG1960	acyl-CoA dehydrogenase activity
AKO66_RS10570	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_RS10575	COG0439	Biotin carboxylase
AKO66_RS10580	COG0511	ligase activity, forming carbon-carbon bonds
AKO66_RS10585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO66_RS10590	COG1024	Enoyl-CoA hydratase
AKO66_RS10595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKO66_RS10600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO66_RS10605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO66_RS10610	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKO66_RS10615	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_RS10635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO66_RS10645	COG1105	Belongs to the carbohydrate kinase PfkB family
AKO66_RS10650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_RS10650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS10650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_RS10655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_RS10655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_RS10655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS10665	COG2814	Major facilitator Superfamily
AKO66_RS10670	COG1846	Transcriptional regulator
AKO66_RS10675	COG5444	nuclease activity
AKO66_RS10705	COG1783	phage Terminase large subunit
AKO66_RS10710	COG5518	Phage portal protein
AKO66_RS10715	COG2369	cell adhesion
AKO66_RS10725	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AKO66_RS10730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS10745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKO66_RS10750	COG1609	Transcriptional regulator
AKO66_RS10755	COG1653	transport
AKO66_RS10760	COG1175	transmembrane transport
AKO66_RS10765	COG0395	ABC-type sugar transport system, permease component
AKO66_RS10770	COG1486	melibiose metabolic process
AKO66_RS10775	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_RS10780	COG3507	Belongs to the glycosyl hydrolase 43 family
AKO66_RS10790	COG0745	RESPONSE REGULATOR receiver
AKO66_RS10795	COG2205	protein histidine kinase activity
AKO66_RS10810	COG2190	(PTS) system
AKO66_RS10810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS10810	COG1263	PTS System
AKO66_RS10815	COG2723	6-phospho-beta-galactosidase activity
AKO66_RS10820	COG0789	Transcriptional regulator
AKO66_RS10825	COG0657	acetylesterase activity
AKO66_RS10865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO66_RS10875	COG0640	Transcriptional regulator
AKO66_RS10880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKO66_RS10885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO66_RS10890	COG0110	maltose O-acetyltransferase activity
AKO66_RS10895	COG0473	3-isopropylmalate dehydrogenase activity
AKO66_RS10900	COG0738	Major facilitator superfamily
AKO66_RS10910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKO66_RS10915	COG0187	DNA topoisomerase II activity
AKO66_RS10920	COG1832	CoA-binding protein
AKO66_RS10925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKO66_RS10930	COG4841	protein insertion into membrane
AKO66_RS10940	COG0824	Thioesterase
AKO66_RS10960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_RS10965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKO66_RS10980	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO66_RS10990	COG4846	Membrane protein involved in cytochrome C biogenesis
AKO66_RS10995	COG0785	Cytochrome C biogenesis protein
AKO66_RS11005	COG3763	UPF0154 protein
AKO66_RS11015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AKO66_RS11020	COG4224	UPF0291 protein
AKO66_RS11025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AKO66_RS11030	COG1388	LysM domain
AKO66_RS11035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKO66_RS11050	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_RS11055	COG3209	COG3209 Rhs family protein
AKO66_RS11060	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKO66_RS11065	COG3591	Belongs to the peptidase S1B family
AKO66_RS11070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKO66_RS11070	COG2124	cytochrome p450
AKO66_RS11075	COG1309	transcriptional regulator
AKO66_RS11080	COG2323	membrane
AKO66_RS11100	COG1556	Lactate utilization protein
AKO66_RS11105	COG1139	Iron-sulfur cluster binding protein
AKO66_RS11110	COG0247	lactate metabolic process
AKO66_RS11120	COG0702	epimerase
AKO66_RS11125	COG1959	2 iron, 2 sulfur cluster binding
AKO66_RS11135	COG4876	unkown
AKO66_RS11140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AKO66_RS11145	COG1793	dna ligase
AKO66_RS11145	COG3285	dna ligase
AKO66_RS11150	COG3619	membrane
AKO66_RS11160	COG0457	Tetratricopeptide repeat
AKO66_RS11185	COG5646	InterPro IPR014922
AKO66_RS11210	COG5444	nuclease activity
AKO66_RS11230	COG0604	alcohol dehydrogenase
AKO66_RS11245	COG0457	Tetratricopeptide repeat
AKO66_RS11275	COG0174	glutamine synthetase
AKO66_RS11280	COG0789	Transcriptional regulator
AKO66_RS11285	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AKO66_RS11290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKO66_RS11295	COG0464	growth
AKO66_RS11305	COG4112	unkown
AKO66_RS11310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKO66_RS11315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKO66_RS11320	COG1780	Probably involved in ribonucleotide reductase function
AKO66_RS11335	COG1923	regulation of RNA biosynthetic process
AKO66_RS11340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKO66_RS11365	COG2076	Multidrug Resistance protein
AKO66_RS11370	COG1764	response to oxidative stress
AKO66_RS11375	COG4195	phage-related replication protein
AKO66_RS11380	COG1404	Belongs to the peptidase S8 family
AKO66_RS11385	COG0457	Tetratricopeptide repeat
AKO66_RS11390	COG4195	phage-related replication protein
AKO66_RS11395	COG1329	Transcriptional regulator
AKO66_RS11415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AKO66_RS11420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKO66_RS11430	COG4550	Control of competence regulator ComK, YlbF/YmcA
AKO66_RS11435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKO66_RS11445	COG0156	8-amino-7-oxononanoate synthase activity
AKO66_RS11450	COG1063	alcohol dehydrogenase
AKO66_RS11455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKO66_RS11460	COG2359	stage V sporulation protein S
AKO66_RS11465	COG1692	metallophosphoesterase
AKO66_RS11470	COG1418	mRNA catabolic process
AKO66_RS11475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AKO66_RS11480	COG1546	Belongs to the CinA family
AKO66_RS11480	COG1058	Belongs to the CinA family
AKO66_RS11485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKO66_RS11490	COG1426	Protein conserved in bacteria
AKO66_RS11505	COG0300	oxidoreductase activity
AKO66_RS11510	COG2409	Drug exporters of the RND superfamily
AKO66_RS11510	COG1033	growth of symbiont in host cell
AKO66_RS11520	COG0612	Peptidase, M16
AKO66_RS11525	COG0612	Peptidase, M16
AKO66_RS11530	COG1033	growth of symbiont in host cell
AKO66_RS11530	COG2409	Drug exporters of the RND superfamily
AKO66_RS11535	COG2814	Major facilitator Superfamily
AKO66_RS11540	COG2188	Transcriptional regulator
AKO66_RS11545	COG1674	ftsk spoiiie
AKO66_RS11545	COG4980	gas vesicle protein
AKO66_RS11555	COG0740	serine-type endopeptidase activity
AKO66_RS11560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKO66_RS11570	COG0527	aspartate kinase activity
AKO66_RS11575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKO66_RS11580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKO66_RS11585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO66_RS11590	COG1873	PFAM PRC-barrel domain
AKO66_RS11595	COG0367	asparagine synthase
AKO66_RS11640	COG1260	myo-inositol-1-phosphate synthase
AKO66_RS11645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO66_RS11650	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS11655	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS11675	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AKO66_RS11710	COG1132	(ABC) transporter
AKO66_RS11715	COG1132	(ABC) transporter
AKO66_RS11725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO66_RS11730	COG0612	Peptidase, M16
AKO66_RS11735	COG0726	polysaccharide deacetylase
AKO66_RS11740	COG1185	polyribonucleotide nucleotidyltransferase activity
AKO66_RS11745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKO66_RS11750	COG0196	riboflavin kinase activity
AKO66_RS11755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKO66_RS11760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKO66_RS11765	COG1550	Protein conserved in bacteria
AKO66_RS11770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKO66_RS11775	COG1358	cellular component organization or biogenesis
AKO66_RS11780	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AKO66_RS11785	COG0195	Participates in both transcription termination and antitermination
AKO66_RS11790	COG0779	Required for maturation of 30S ribosomal subunits
AKO66_RS11800	COG3693	PFAM glycoside hydrolase, family 10
AKO66_RS11815	COG2176	DNA-directed DNA polymerase activity
AKO66_RS11820	COG0442	prolyl-tRNA aminoacylation
AKO66_RS11825	COG0750	zinc metalloprotease
AKO66_RS11830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKO66_RS11835	COG4589	Belongs to the CDS family
AKO66_RS11840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKO66_RS11845	COG0233	cytoplasmic translational termination
AKO66_RS11850	COG0528	UMP kinase activity
AKO66_RS11855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKO66_RS11870	COG1191	sigma factor activity
AKO66_RS11880	COG1776	CheC inhibitor of MCP methylation
AKO66_RS11885	COG0835	chemotaxis
AKO66_RS11890	COG2198	Histidine kinase
AKO66_RS11890	COG0643	Histidine kinase
AKO66_RS11895	COG2201	protein-glutamate methylesterase activity
AKO66_RS11900	COG0455	bacterial-type flagellum organization
AKO66_RS11905	COG1419	protein localization to endoplasmic reticulum
AKO66_RS11910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKO66_RS11915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKO66_RS11920	COG1684	flagellar biosynthetic protein fliR
AKO66_RS11925	COG1987	bacterial-type flagellum assembly
AKO66_RS11930	COG1338	Plays a role in the flagellum-specific transport system
AKO66_RS11935	COG3190	flagellar
AKO66_RS11940	COG2201	protein-glutamate methylesterase activity
AKO66_RS11945	COG1776	CheC inhibitor of MCP methylation
AKO66_RS11945	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO66_RS11950	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO66_RS11955	COG1580	Controls the rotational direction of flagella during chemotaxis
AKO66_RS11960	COG1582	Flagellar protein (FlbD)
AKO66_RS11965	COG4786	Flagellar basal body rod
AKO66_RS11970	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AKO66_RS11980	COG3334	PFAM MgtE intracellular
AKO66_RS11985	COG2882	bacterial-type flagellum organization
AKO66_RS11990	COG1157	protein secretion by the type III secretion system
AKO66_RS11995	COG1317	bacterial-type flagellum organization
AKO66_RS12000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO66_RS12005	COG1766	The M ring may be actively involved in energy transduction
AKO66_RS12010	COG1677	Flagellar hook-basal body complex protein FliE
AKO66_RS12015	COG1558	bacterial-type flagellum-dependent cell motility
AKO66_RS12020	COG1815	bacterial-type flagellum-dependent cell motility
AKO66_RS12025	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AKO66_RS12030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKO66_RS12035	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AKO66_RS12040	COG4974	Belongs to the 'phage' integrase family
AKO66_RS12045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AKO66_RS12050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKO66_RS12055	COG0758	DNA mediated transformation
AKO66_RS12060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKO66_RS12065	COG0045	succinate-CoA ligase (ADP-forming) activity
AKO66_RS12070	COG2257	FlhB HrpN YscU SpaS Family
AKO66_RS12080	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKO66_RS12085	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AKO66_RS12090	COG0335	large ribosomal subunit rRNA binding
AKO66_RS12095	COG0336	Belongs to the RNA methyltransferase TrmD family
AKO66_RS12100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKO66_RS12110	COG1837	Belongs to the UPF0109 family
AKO66_RS12115	COG0228	four-way junction DNA binding
AKO66_RS12120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKO66_RS12125	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AKO66_RS12130	COG0552	protein localization to endoplasmic reticulum
AKO66_RS12135	COG1196	nuclear chromosome segregation
AKO66_RS12145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO66_RS12150	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS12155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKO66_RS12160	COG0416	fatty acid biosynthetic process
AKO66_RS12165	COG1349	DNA-binding transcription factor activity
AKO66_RS12170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKO66_RS12175	COG1760	l-serine dehydratase
AKO66_RS12180	COG1760	l-serine dehydratase
AKO66_RS12185	COG1461	Dihydroxyacetone kinase
AKO66_RS12190	COG1302	Protein conserved in bacteria
AKO66_RS12195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKO66_RS12205	COG1564	THIamine pyrophosphokinase
AKO66_RS12210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKO66_RS12215	COG1162	GTPase activity
AKO66_RS12220	COG0515	serine threonine protein kinase
AKO66_RS12220	COG2815	serine threonine protein kinase
AKO66_RS12225	COG0631	protein serine/threonine phosphatase activity
AKO66_RS12230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKO66_RS12235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKO66_RS12235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKO66_RS12240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKO66_RS12245	COG0242	peptide deformylase activity
AKO66_RS12250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKO66_RS12255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKO66_RS12260	COG1758	RNA polymerase activity
AKO66_RS12265	COG0194	GDP metabolic process
AKO66_RS12270	COG2052	Domain of unknown function (DUF370)
AKO66_RS12275	COG1561	YicC-like family, N-terminal region
AKO66_RS12280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKO66_RS12290	COG1648	precorrin-2 dehydrogenase activity
AKO66_RS12295	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
AKO66_RS12300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKO66_RS12305	COG0529	Catalyzes the synthesis of activated sulfate
AKO66_RS12310	COG2046	Belongs to the sulfate adenylyltransferase family
AKO66_RS12315	COG0306	phosphate transporter
AKO66_RS12320	COG0175	sulfate reduction
AKO66_RS12325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKO66_RS12330	COG0284	orotidine-5'-phosphate decarboxylase activity
AKO66_RS12335	COG0167	dihydroorotate dehydrogenase activity
AKO66_RS12340	COG0543	2 iron, 2 sulfur cluster binding
AKO66_RS12345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKO66_RS12350	COG0505	Belongs to the CarA family
AKO66_RS12355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKO66_RS12360	COG0540	Belongs to the ATCase OTCase family
AKO66_RS12365	COG2233	PERMEase
AKO66_RS12370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AKO66_RS12375	COG0564	pseudouridine synthase activity
AKO66_RS12380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKO66_RS12385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO66_RS12390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKO66_RS12395	COG3599	regulation of cell shape
AKO66_RS12400	COG2302	S4 RNA-binding domain
AKO66_RS12405	COG0762	integral membrane protein
AKO66_RS12410	COG1799	cell septum assembly
AKO66_RS12415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKO66_RS12420	COG1496	oxidoreductase activity
AKO66_RS12425	COG1873	PFAM PRC-barrel domain
AKO66_RS12430	COG1119	ATPase activity
AKO66_RS12440	COG3732	PTS system glucitol sorbitol-specific
AKO66_RS12445	COG3730	PTS system glucitol sorbitol-specific
AKO66_RS12460	COG2390	Transcriptional regulator
AKO66_RS12465	COG1191	sigma factor activity
AKO66_RS12470	COG1191	sigma factor activity
AKO66_RS12480	COG4412	M6 family metalloprotease domain protein
AKO66_RS12480	COG1404	Belongs to the peptidase S8 family
AKO66_RS12485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKO66_RS12490	COG0849	cell division
AKO66_RS12495	COG3856	small basic protein
AKO66_RS12500	COG3879	Bacterial protein of unknown function (DUF881)
AKO66_RS12505	COG3879	Bacterial protein of unknown function (DUF881)
AKO66_RS12510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AKO66_RS12515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKO66_RS12520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKO66_RS12525	COG0772	Belongs to the SEDS family
AKO66_RS12530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKO66_RS12535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKO66_RS12540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKO66_RS12545	COG0768	penicillin binding
AKO66_RS12550	COG0768	penicillin binding
AKO66_RS12555	COG4839	cell division protein FtsL
AKO66_RS12560	COG0275	rRNA processing
AKO66_RS12565	COG2001	Belongs to the MraZ family
AKO66_RS12570	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AKO66_RS12575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKO66_RS12580	COG0454	-acetyltransferase
AKO66_RS12590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKO66_RS12595	COG1399	metal-binding, possibly nucleic acid-binding protein
AKO66_RS12605	COG3480	Lon protease (S16) C-terminal proteolytic domain
AKO66_RS12610	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKO66_RS12615	COG3314	Sporulation integral membrane protein YlbJ
AKO66_RS12620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKO66_RS12625	COG0742	ribosomal rna small subunit methyltransferase
AKO66_RS12630	COG4471	UPF0298 protein
AKO66_RS12635	COG3679	Belongs to the UPF0342 family
AKO66_RS12655	COG2340	Cysteine-rich secretory protein family
AKO66_RS12660	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AKO66_RS12670	COG3336	cytochrome c oxidase
AKO66_RS12675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AKO66_RS12680	COG1845	cytochrome c oxidase, subunit III
AKO66_RS12685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKO66_RS12690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKO66_RS12690	COG2010	Cytochrome c
AKO66_RS12695	COG0109	protoheme IX farnesyltransferase activity
AKO66_RS12700	COG1612	heme a metabolic process
AKO66_RS12705	COG0415	Belongs to the DNA photolyase family
AKO66_RS12710	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AKO66_RS12715	COG0772	Belongs to the SEDS family
AKO66_RS12720	COG4838	Belongs to the UPF0358 family
AKO66_RS12725	COG2066	Belongs to the glutaminase family
AKO66_RS12730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AKO66_RS12735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKO66_RS12745	COG4896	Protein conserved in bacteria
AKO66_RS12755	COG1217	gtp-binding protein TYPA
AKO66_RS12775	COG1595	DNA-templated transcription, initiation
AKO66_RS12785	COG0483	inositol monophosphate 1-phosphatase activity
AKO66_RS12795	COG4493	Belongs to the UPF0637 family
AKO66_RS12800	COG4476	Belongs to the UPF0223 family
AKO66_RS12805	COG1982	Orn Lys Arg decarboxylase major
AKO66_RS12810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_RS12815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO66_RS12820	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_RS12825	COG0022	dehydrogenase e1 component
AKO66_RS12830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO66_RS12845	COG0242	peptide deformylase activity
AKO66_RS12850	COG0561	phosphatase activity
AKO66_RS12855	COG5503	Protein of unknown function (DUF1447)
AKO66_RS12860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKO66_RS12865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKO66_RS12870	COG0569	domain protein
AKO66_RS12875	COG2105	PFAM AIG2 family protein
AKO66_RS12875	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AKO66_RS12880	COG3852	Histidine kinase
AKO66_RS12885	COG2002	toxin-antitoxin pair type II binding
AKO66_RS12890	COG1077	Cell shape determining protein MreB Mrl
AKO66_RS12895	COG2309	aminopeptidase activity
AKO66_RS12905	COG0488	(ABC) transporter
AKO66_RS12915	COG0681	Belongs to the peptidase S26 family
AKO66_RS12920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS12920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_RS12920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_RS12925	COG1105	Belongs to the carbohydrate kinase PfkB family
AKO66_RS12930	COG1349	DNA-binding transcription factor activity
AKO66_RS12935	COG0577	efflux transmembrane transporter activity
AKO66_RS12940	COG1136	(ABC) transporter
AKO66_RS12945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKO66_RS12960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AKO66_RS12965	COG0314	molybdopterin synthase activity
AKO66_RS12970	COG1763	Mo-molybdopterin cofactor biosynthetic process
AKO66_RS12975	COG0303	'Molybdopterin
AKO66_RS12980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKO66_RS12985	COG0746	molybdenum cofactor guanylyltransferase activity
AKO66_RS13000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_RS13005	COG0450	alkyl hydroperoxide reductase
AKO66_RS13010	COG0668	transmembrane transport
AKO66_RS13020	COG1473	amidohydrolase
AKO66_RS13025	COG2171	N-acyltransferase activity
AKO66_RS13030	COG0716	FMN binding
AKO66_RS13040	COG0716	FMN binding
AKO66_RS13050	COG0583	DNA-binding transcription factor activity
AKO66_RS13055	COG0517	IMP dehydrogenase activity
AKO66_RS13065	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AKO66_RS13070	COG4703	Protein of unknown function (DUF1797)
AKO66_RS13075	COG3546	catalase activity
AKO66_RS13080	COG2200	EAL domain
AKO66_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS13090	COG1408	metallophosphoesterase
AKO66_RS13095	COG1376	ErfK ybiS ycfS ynhG family protein
AKO66_RS13100	COG2814	Major facilitator Superfamily
AKO66_RS13120	COG0784	Response regulator, receiver
AKO66_RS13120	COG0835	chemotaxis
AKO66_RS13130	COG1714	RDD family
AKO66_RS13135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKO66_RS13140	COG0436	Aminotransferase
AKO66_RS13145	COG4191	Histidine kinase
AKO66_RS13150	COG0768	penicillin binding
AKO66_RS13155	COG2340	Cysteine-rich secretory protein family
AKO66_RS13160	COG2084	Dehydrogenase
AKO66_RS13170	COG0840	transmembrane signaling receptor activity
AKO66_RS13175	COG1533	DNA photolyase activity
AKO66_RS13185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKO66_RS13190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS13195	COG1263	PTS System
AKO66_RS13195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS13195	COG2190	(PTS) system
AKO66_RS13200	COG3711	transcriptional antiterminator
AKO66_RS13205	COG1609	Transcriptional regulator
AKO66_RS13210	COG0006	proline dipeptidase activity
AKO66_RS13215	COG2217	Heavy metal translocating P-type atpase
AKO66_RS13220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_RS13225	COG2244	polysaccharide biosynthetic process
AKO66_RS13230	COG3773	Cell wall hydrolase
AKO66_RS13240	COG4873	Protein conserved in bacteria
AKO66_RS13250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKO66_RS13255	COG0602	queuosine metabolic process
AKO66_RS13260	COG0720	synthase
AKO66_RS13265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKO66_RS13270	COG3949	Membrane
AKO66_RS13275	COG0542	response to heat
AKO66_RS13280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AKO66_RS13285	COG1360	Flagellar Motor Protein
AKO66_RS13290	COG1846	Transcriptional regulator
AKO66_RS13295	COG3852	Histidine kinase
AKO66_RS13305	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AKO66_RS13310	COG0235	Class ii aldolase
AKO66_RS13315	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AKO66_RS13320	COG1850	ribulose-bisphosphate carboxylase activity
AKO66_RS13325	COG0436	Aminotransferase
AKO66_RS13330	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AKO66_RS13335	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKO66_RS13340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKO66_RS13345	COG5002	protein histidine kinase activity
AKO66_RS13350	COG3594	Acyltransferase
AKO66_RS13360	COG2323	membrane
AKO66_RS13365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKO66_RS13370	COG0501	Belongs to the peptidase M48B family
AKO66_RS13390	COG1191	sigma factor activity
AKO66_RS13395	COG0861	Integral membrane protein TerC family
AKO66_RS13400	COG0586	Pfam SNARE associated Golgi protein
AKO66_RS13405	COG3300	MHYT domain
AKO66_RS13405	COG5001	Diguanylate cyclase
AKO66_RS13410	COG1846	Transcriptional regulator
AKO66_RS13420	COG0789	Transcriptional regulator
AKO66_RS13430	COG0583	DNA-binding transcription factor activity
AKO66_RS13440	COG2239	Acts as a magnesium transporter
AKO66_RS13450	COG3212	peptidase
AKO66_RS13455	COG3212	peptidase
AKO66_RS13460	COG5002	protein histidine kinase activity
AKO66_RS13460	COG3850	Histidine kinase
AKO66_RS13465	COG0745	RESPONSE REGULATOR receiver
AKO66_RS13480	COG1404	Belongs to the peptidase S8 family
AKO66_RS13485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKO66_RS13490	COG0590	tRNA wobble adenosine to inosine editing
AKO66_RS13495	COG1764	response to oxidative stress
AKO66_RS13500	COG1846	Transcriptional regulator
AKO66_RS13505	COG1764	response to oxidative stress
AKO66_RS13515	COG0457	Tetratricopeptide repeat
AKO66_RS13520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKO66_RS13525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKO66_RS13530	COG0788	formyltetrahydrofolate deformylase activity
AKO66_RS13540	COG2076	Multidrug Resistance protein
AKO66_RS13545	COG2076	Multidrug Resistance protein
AKO66_RS13555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO66_RS13570	COG1695	Transcriptional regulator
AKO66_RS13575	COG1607	acyl-coa hydrolase
AKO66_RS13580	COG1834	amidinotransferase
AKO66_RS13585	COG4608	Belongs to the ABC transporter superfamily
AKO66_RS13590	COG0791	NLP P60 protein
AKO66_RS13595	COG4948	Mandelate Racemase Muconate Lactonizing
AKO66_RS13600	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO66_RS13605	COG4166	transmembrane transport
AKO66_RS13610	COG0444	Belongs to the ABC transporter superfamily
AKO66_RS13615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO66_RS13620	COG0601	transmembrane transport
AKO66_RS13625	COG2362	D-Aminopeptidase
AKO66_RS13630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO66_RS13635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO66_RS13640	COG0346	lactoylglutathione lyase activity
AKO66_RS13645	COG0531	amino acid
AKO66_RS13655	COG2390	Transcriptional regulator
AKO66_RS13660	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS13665	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS13670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO66_RS13675	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_RS13680	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_RS13680	COG0022	dehydrogenase e1 component
AKO66_RS13685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO66_RS13690	COG1063	alcohol dehydrogenase
AKO66_RS13705	COG3775	system Galactitol-specific IIC component
AKO66_RS13715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AKO66_RS13720	COG4208	sulfate ABC transporter
AKO66_RS13730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKO66_RS13735	COG0405	Gamma-glutamyltransferase
AKO66_RS13745	COG1392	Phosphate transport regulator
AKO66_RS13750	COG0306	phosphate transporter
AKO66_RS13765	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_RS13765	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKO66_RS13775	COG2856	Zn peptidase
AKO66_RS13780	COG4195	phage-related replication protein
AKO66_RS13800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_RS13805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_RS13810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_RS13815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_RS13825	COG1309	transcriptional regulator
AKO66_RS13835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKO66_RS13870	COG2807	transmembrane transport
AKO66_RS13875	COG0583	DNA-binding transcription factor activity
AKO66_RS13895	COG0583	DNA-binding transcription factor activity
AKO66_RS13920	COG0457	Tetratricopeptide repeat
AKO66_RS13930	COG2364	Membrane
AKO66_RS13935	COG2153	protein acetylation
AKO66_RS13940	COG0457	Tetratricopeptide repeat
AKO66_RS13950	COG0583	DNA-binding transcription factor activity
AKO66_RS13960	COG2807	transmembrane transport
AKO66_RS13980	COG0825	malonyl-CoA metabolic process
AKO66_RS13985	COG0113	porphobilinogen synthase activity
AKO66_RS14115	COG0626	cystathionine gamma-synthase activity
AKO66_RS14120	COG0626	cystathionine gamma-synthase activity
AKO66_RS14125	COG2382	esterase
AKO66_RS14130	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKO66_RS14135	COG2153	protein acetylation
AKO66_RS14145	COG0210	DNA helicase
AKO66_RS14200	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AKO66_RS14205	COG0351	phosphomethylpyrimidine kinase
AKO66_RS14210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKO66_RS14215	COG2022	thiamine diphosphate biosynthetic process
AKO66_RS14220	COG2104	thiamine diphosphate biosynthetic process
AKO66_RS14230	COG0352	thiamine-phosphate diphosphorylase activity
AKO66_RS14235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKO66_RS14240	COG0475	glutathione-regulated potassium exporter activity
AKO66_RS14240	COG0569	domain protein
AKO66_RS14245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKO66_RS14250	COG0564	pseudouridine synthase activity
AKO66_RS14255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKO66_RS14260	COG2357	RelA SpoT domain protein
AKO66_RS14270	COG4116	CYTH
AKO66_RS14275	COG0741	lytic transglycosylase activity
AKO66_RS14280	COG2346	COG2346, Truncated hemoglobins
AKO66_RS14285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AKO66_RS14290	COG1164	Oligoendopeptidase f
AKO66_RS14300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO66_RS14305	COG4862	establishment of competence for transformation
AKO66_RS14310	COG0861	Integral membrane protein TerC family
AKO66_RS14315	COG1393	Belongs to the ArsC family
AKO66_RS14320	COG0456	acetyltransferase
AKO66_RS14330	COG4608	Belongs to the ABC transporter superfamily
AKO66_RS14335	COG0444	Belongs to the ABC transporter superfamily
AKO66_RS14340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO66_RS14345	COG0601	transmembrane transport
AKO66_RS14350	COG4166	transmembrane transport
AKO66_RS14355	COG0180	Tryptophanyl-tRNA synthetase
AKO66_RS14365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO66_RS14370	COG0601	transmembrane transport
AKO66_RS14380	COG4608	Belongs to the ABC transporter superfamily
AKO66_RS14385	COG0444	Belongs to the ABC transporter superfamily
AKO66_RS14390	COG5504	Zn-dependent protease
AKO66_RS14395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKO66_RS14400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKO66_RS14415	COG1744	ABC transporter substrate-binding protein PnrA-like
AKO66_RS14425	COG2267	carboxylic ester hydrolase activity
AKO66_RS14435	COG2814	Major facilitator Superfamily
AKO66_RS14445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKO66_RS14450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKO66_RS14455	COG0505	Belongs to the CarA family
AKO66_RS14460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKO66_RS14465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKO66_RS14470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKO66_RS14475	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKO66_RS14480	COG2271	Major facilitator Superfamily
AKO66_RS14485	COG0277	FAD linked oxidase domain protein
AKO66_RS14490	COG2151	metal-sulfur cluster biosynthetic enzyme
AKO66_RS14495	COG1073	alpha beta
AKO66_RS14500	COG0561	phosphatase activity
AKO66_RS14520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_RS14525	COG1307	EDD domain protein, DegV family
AKO66_RS14530	COG0840	transmembrane signaling receptor activity
AKO66_RS14535	COG1744	ABC transporter substrate-binding protein PnrA-like
AKO66_RS14540	COG2996	Protein conserved in bacteria
AKO66_RS14545	COG1666	GTP binding
AKO66_RS14550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKO66_RS14550	COG0646	methionine synthase
AKO66_RS14555	COG0646	methionine synthase
AKO66_RS14555	COG1410	methionine synthase
AKO66_RS14590	COG0076	glutamate decarboxylase activity
AKO66_RS14615	COG1917	Cupin 2, conserved barrel domain protein
AKO66_RS14615	COG2207	Transcriptional regulator
AKO66_RS14620	COG0534	Mate efflux family protein
AKO66_RS14625	COG1562	ergosterol biosynthetic process
AKO66_RS14640	COG0367	asparagine synthase
AKO66_RS14655	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKO66_RS14670	COG5337	Spore coat protein CotH
AKO66_RS14710	COG1403	HNH endonuclease
AKO66_RS14715	COG0419	ATPase involved in DNA repair
AKO66_RS14720	COG0420	3'-5' exonuclease activity
AKO66_RS14725	COG1074	ATP-dependent DNA helicase activity
AKO66_RS14730	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AKO66_RS14735	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AKO66_RS14740	COG2259	Doxx family
AKO66_RS14755	COG3180	Ammonia monooxygenase
AKO66_RS14760	COG0681	Belongs to the peptidase S26 family
AKO66_RS14765	COG0398	Pfam SNARE associated Golgi protein
AKO66_RS14780	COG1316	TRANSCRIPTIONal
AKO66_RS14785	COG4607	ABC-type enterochelin transport system periplasmic component
AKO66_RS14790	COG4604	ABC transporter, ATP-binding protein
AKO66_RS14795	COG4605	iron ion homeostasis
AKO66_RS14800	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_RS14805	COG2732	(Barnase) inhibitor
AKO66_RS14810	COG2814	Major facilitator Superfamily
AKO66_RS14815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_RS14830	COG4903	ComK protein
AKO66_RS14840	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS14845	COG0723	plastoquinol--plastocyanin reductase activity
AKO66_RS14845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKO66_RS14850	COG0840	transmembrane signaling receptor activity
AKO66_RS14855	COG0406	alpha-ribazole phosphatase activity
AKO66_RS14860	COG1404	Belongs to the peptidase S8 family
AKO66_RS14865	COG0501	Belongs to the peptidase M48B family
AKO66_RS14875	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_RS14880	COG0095	Lipoate-protein ligase
AKO66_RS14885	COG1234	tRNA 3'-trailer cleavage
AKO66_RS14895	COG1301	dicarboxylic acid transport
AKO66_RS14900	COG1363	Peptidase, m42
AKO66_RS14905	COG1511	domain protein
AKO66_RS14910	COG1309	transcriptional regulator
AKO66_RS14915	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AKO66_RS14920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKO66_RS14925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKO66_RS14930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO66_RS14935	COG2329	Antibiotic biosynthesis monooxygenase
AKO66_RS14945	COG1473	amidohydrolase
AKO66_RS14955	COG4473	ABC transporter
AKO66_RS14960	COG1131	(ABC) transporter
AKO66_RS14965	COG0537	adenosine 5'-monophosphoramidase activity
AKO66_RS14970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AKO66_RS14985	COG4980	gas vesicle protein
AKO66_RS14990	COG1846	Transcriptional regulator
AKO66_RS15010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKO66_RS15020	COG3481	metal-dependent phosphohydrolase, HD sub domain
AKO66_RS15025	COG4717	serine-type aminopeptidase activity
AKO66_RS15030	COG0420	3'-5' exonuclease activity
AKO66_RS15040	COG1024	Enoyl-CoA hydratase
AKO66_RS15050	COG0490	domain, Protein
AKO66_RS15055	COG0475	glutathione-regulated potassium exporter activity
AKO66_RS15065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKO66_RS15070	COG0561	phosphatase activity
AKO66_RS15075	COG3679	Belongs to the UPF0342 family
AKO66_RS15080	COG4399	Belongs to the UPF0754 family
AKO66_RS15085	COG0189	ligase activity
AKO66_RS15090	COG0189	ligase activity
AKO66_RS15100	COG2508	Transcriptional regulator
AKO66_RS15105	COG3842	ATPase activity
AKO66_RS15115	COG0702	epimerase
AKO66_RS15120	COG1132	(ABC) transporter
AKO66_RS15125	COG1132	(ABC) transporter
AKO66_RS15130	COG0589	response to stress
AKO66_RS15135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO66_RS15140	COG0726	polysaccharide deacetylase
AKO66_RS15145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKO66_RS15150	COG0668	transmembrane transport
AKO66_RS15155	COG0584	glycerophosphoryl diester phosphodiesterase
AKO66_RS15160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKO66_RS15175	COG1253	flavin adenine dinucleotide binding
AKO66_RS15180	COG0789	Transcriptional regulator
AKO66_RS15185	COG1253	flavin adenine dinucleotide binding
AKO66_RS15190	COG0204	Acyl-transferase
AKO66_RS15195	COG1595	DNA-templated transcription, initiation
AKO66_RS15210	COG0531	amino acid
AKO66_RS15215	COG0791	NLP P60 protein
AKO66_RS15215	COG1388	LysM domain
AKO66_RS15220	COG1785	Belongs to the alkaline phosphatase family
AKO66_RS15225	COG2719	SpoVR family
AKO66_RS15230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKO66_RS15230	COG1017	nitric oxide dioxygenase activity
AKO66_RS15235	COG1959	2 iron, 2 sulfur cluster binding
AKO66_RS15240	COG0753	catalase activity
AKO66_RS15255	COG2197	response regulator
AKO66_RS15260	COG2203	Gaf domain
AKO66_RS15260	COG4585	Histidine kinase
AKO66_RS15265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKO66_RS15270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKO66_RS15275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AKO66_RS15280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AKO66_RS15285	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AKO66_RS15290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKO66_RS15295	COG3835	regulator
AKO66_RS15315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKO66_RS15315	COG3153	acetyltransferase
AKO66_RS15320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKO66_RS15330	COG0564	pseudouridine synthase activity
AKO66_RS15335	COG3764	Sortase (surface protein transpeptidase)
AKO66_RS15340	COG0737	Belongs to the 5'-nucleotidase family
AKO66_RS15340	COG1525	nuclease
AKO66_RS15340	COG4085	toxin activity
AKO66_RS15345	COG5002	protein histidine kinase activity
AKO66_RS15350	COG5577	PFAM Coat F domain
AKO66_RS15375	COG3706	GGDEF domain
AKO66_RS15380	COG1278	Cold shock
AKO66_RS15390	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKO66_RS15395	COG2814	Major facilitator Superfamily
AKO66_RS15400	COG1566	PFAM secretion protein HlyD family protein
AKO66_RS15405	COG2718	Belongs to the UPF0229 family
AKO66_RS15410	COG2766	serine protein kinase
AKO66_RS15415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKO66_RS15425	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKO66_RS15430	COG3382	B3 4 domain protein
AKO66_RS15460	COG1131	(ABC) transporter
AKO66_RS15475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKO66_RS15480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKO66_RS15485	COG1116	anion transmembrane transporter activity
AKO66_RS15495	COG2873	o-acetylhomoserine
AKO66_RS15500	COG0681	Belongs to the peptidase S26 family
AKO66_RS15505	COG1368	sulfuric ester hydrolase activity
AKO66_RS15660	COG0735	belongs to the Fur family
AKO66_RS15665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKO66_RS15670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKO66_RS15675	COG4129	membrane
AKO66_RS15680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO66_RS15685	COG0601	transmembrane transport
AKO66_RS15690	COG0747	negative chemotaxis
AKO66_RS15695	COG4608	Belongs to the ABC transporter superfamily
AKO66_RS15700	COG0444	Belongs to the ABC transporter superfamily
AKO66_RS15705	COG1132	(ABC) transporter
AKO66_RS15710	COG3557	Belongs to the UPF0374 family
AKO66_RS15725	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS15735	COG1194	a g-specific adenine glycosylase
AKO66_RS15740	COG1988	membrane-bound metal-dependent
AKO66_RS15750	COG1191	sigma factor activity
AKO66_RS15755	COG2140	Oxalate decarboxylase
AKO66_RS15770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKO66_RS15775	COG4485	Bacterial membrane protein, YfhO
AKO66_RS15780	COG0463	Glycosyl transferase, family 2
AKO66_RS15800	COG2137	regulation of response to DNA damage stimulus
AKO66_RS15805	COG1090	epimerase
AKO66_RS15820	COG0778	Nitroreductase
AKO66_RS15840	COG0392	lysyltransferase activity
AKO66_RS15840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AKO66_RS15845	COG1846	Transcriptional regulator
AKO66_RS15855	COG2318	DinB family
AKO66_RS15875	COG1595	DNA-templated transcription, initiation
AKO66_RS15880	COG1742	UPF0060 membrane protein
AKO66_RS15885	COG1132	(ABC) transporter
AKO66_RS15890	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AKO66_RS15895	COG2169	Transcriptional regulator
AKO66_RS15900	COG0492	ferredoxin-NADP+ reductase activity
AKO66_RS15905	COG2755	lipolytic protein G-D-S-L family
AKO66_RS15910	COG4637	Psort location Cytoplasmic, score
AKO66_RS15920	COG1309	transcriptional regulator
AKO66_RS15925	COG2076	Multidrug Resistance protein
AKO66_RS15930	COG2076	Multidrug Resistance protein
AKO66_RS15985	COG2814	Major facilitator Superfamily
AKO66_RS15990	COG0789	Transcriptional regulator
AKO66_RS15995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKO66_RS16000	COG1942	4-Oxalocrotonate Tautomerase
AKO66_RS16020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKO66_RS16025	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AKO66_RS16035	COG0598	Magnesium transport protein CorA
AKO66_RS16045	COG0726	polysaccharide deacetylase
AKO66_RS16055	COG0535	radical SAM domain protein
AKO66_RS16060	COG0668	transmembrane transport
AKO66_RS16070	COG0217	transcriptional regulatory protein
AKO66_RS16080	COG0387	Pfam Sodium calcium exchanger
AKO66_RS16090	COG0477	Major facilitator Superfamily
AKO66_RS16095	COG1295	ribonuclease BN
AKO66_RS16100	COG4980	gas vesicle protein
AKO66_RS16105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO66_RS16110	COG1115	amino acid carrier protein
AKO66_RS16115	COG4840	Belongs to the UPF0435 family
AKO66_RS16120	COG0693	protein deglycase activity
AKO66_RS16125	COG0737	Belongs to the 5'-nucleotidase family
AKO66_RS16135	COG2188	Transcriptional regulator
AKO66_RS16140	COG0366	Alpha amylase catalytic
AKO66_RS16145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS16145	COG1263	PTS System
AKO66_RS16160	COG0076	glutamate decarboxylase activity
AKO66_RS16165	COG1368	sulfuric ester hydrolase activity
AKO66_RS16180	COG3739	integral membrane protein
AKO66_RS16185	COG1263	PTS System
AKO66_RS16185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS16190	COG0024	Methionine aminopeptidase
AKO66_RS16200	COG2258	MOSC domain
AKO66_RS16205	COG1254	Belongs to the acylphosphatase family
AKO66_RS16215	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AKO66_RS16220	COG1695	Transcriptional regulator
AKO66_RS16225	COG3479	Phenolic acid decarboxylase
AKO66_RS16235	COG2851	Citrate transporter
AKO66_RS16240	COG3181	Tripartite tricarboxylate transporter family receptor
AKO66_RS16245	COG4565	transcriptional regulatory protein
AKO66_RS16250	COG3290	protein histidine kinase activity
AKO66_RS16260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO66_RS16260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO66_RS16270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKO66_RS16275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO66_RS16275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO66_RS16295	COG2130	NADP-dependent
AKO66_RS16300	COG0513	Belongs to the DEAD box helicase family
AKO66_RS16305	COG0488	(ABC) transporter
AKO66_RS16310	COG2814	Major facilitator Superfamily
AKO66_RS16315	COG0789	Transcriptional regulator
AKO66_RS16320	COG1469	GTP cyclohydrolase I activity
AKO66_RS16325	COG0488	(ABC) transporter
AKO66_RS16330	COG0457	Tetratricopeptide repeat
AKO66_RS16330	COG0463	Glycosyl transferase, family 2
AKO66_RS16335	COG0531	amino acid
AKO66_RS16350	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO66_RS16365	COG0471	metal ion transport
AKO66_RS16375	COG2223	nitrite transmembrane transporter activity
AKO66_RS16380	COG1442	glycosyl transferase family 8
AKO66_RS16385	COG1216	Glycosyl transferase, family 2
AKO66_RS16390	COG1442	glycosyl transferase family 8
AKO66_RS16395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO66_RS16400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKO66_RS16425	COG2211	Major facilitator Superfamily
AKO66_RS16435	COG1486	melibiose metabolic process
AKO66_RS16450	COG0492	ferredoxin-NADP+ reductase activity
AKO66_RS16455	COG1959	2 iron, 2 sulfur cluster binding
AKO66_RS16470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKO66_RS16475	COG5444	nuclease activity
AKO66_RS16485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKO66_RS16490	COG1597	lipid kinase activity
AKO66_RS16495	COG1957	nucleoside hydrolase
AKO66_RS16500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKO66_RS16505	COG1309	transcriptional regulator
AKO66_RS16510	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKO66_RS16515	COG0154	amidase activity
AKO66_RS16520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKO66_RS16525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO66_RS16530	COG1285	pathogenesis
AKO66_RS16535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO66_RS16540	COG4851	CamS sex pheromone cAM373 precursor
AKO66_RS16545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKO66_RS16550	COG0210	DNA helicase
AKO66_RS16555	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AKO66_RS16570	COG0069	glutamate synthase activity
AKO66_RS16580	COG4496	protein, YerC YecD
AKO66_RS16585	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKO66_RS16595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKO66_RS16600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKO66_RS16605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AKO66_RS16610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKO66_RS16630	COG0151	Belongs to the GarS family
AKO66_RS16635	COG0138	bifunctional purine biosynthesis protein purh
AKO66_RS16640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKO66_RS16645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKO66_RS16650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AKO66_RS16655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKO66_RS16660	COG0047	phosphoribosylformylglycinamidine synthase activity
AKO66_RS16665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKO66_RS16670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKO66_RS16675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKO66_RS16680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AKO66_RS16685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AKO66_RS16695	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AKO66_RS16700	COG3064	Membrane
AKO66_RS16705	COG5583	Uncharacterized small protein (DUF2292)
AKO66_RS16710	COG2252	PERMEase
AKO66_RS16715	COG0583	DNA-binding transcription factor activity
AKO66_RS16720	COG2814	Major facilitator Superfamily
AKO66_RS16730	COG1595	DNA-templated transcription, initiation
AKO66_RS16750	COG3279	Response regulator of the LytR AlgR family
AKO66_RS16780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO66_RS16790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKO66_RS16800	COG0519	Catalyzes the synthesis of GMP from XMP
AKO66_RS16800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKO66_RS16805	COG1305	Transglutaminase-like
AKO66_RS16810	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AKO66_RS16815	COG0714	Associated with various cellular activities
AKO66_RS16820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKO66_RS16825	COG1113	amino acid transport
AKO66_RS16830	COG2132	Multicopper oxidase
AKO66_RS16840	COG0823	Involved in the tonB-independent uptake of proteins
AKO66_RS16845	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKO66_RS16870	COG1876	peptidase activity
AKO66_RS16875	COG2808	Putative FMN-binding domain
AKO66_RS16880	COG1846	Transcriptional regulator
AKO66_RS16905	COG0459	protein refolding
AKO66_RS16910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKO66_RS16915	COG1266	CAAX protease self-immunity
AKO66_RS16930	COG0805	protein transport
AKO66_RS16935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKO66_RS16940	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AKO66_RS16945	COG0315	cyclic pyranopterin monophosphate synthase activity
AKO66_RS16950	COG0488	(ABC) transporter
AKO66_RS16955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKO66_RS16960	COG0456	acetyltransferase
AKO66_RS16965	COG1214	PFAM Peptidase M22, glycoprotease
AKO66_RS16970	COG0802	atpase or kinase
AKO66_RS16975	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AKO66_RS17025	COG1301	dicarboxylic acid transport
AKO66_RS17035	COG0697	spore germination
AKO66_RS17040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKO66_RS17050	COG4122	O-methyltransferase activity
AKO66_RS17060	COG0456	acetyltransferase
AKO66_RS17070	COG1396	sequence-specific DNA binding
AKO66_RS17085	COG0778	Nitroreductase
AKO66_RS17090	COG1846	Transcriptional regulator
AKO66_RS17095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AKO66_RS17100	COG1309	transcriptional regulator
AKO66_RS17145	COG2814	Major facilitator Superfamily
AKO66_RS17165	COG2267	carboxylic ester hydrolase activity
AKO66_RS17170	COG0252	asparaginase activity
AKO66_RS17180	COG4221	oxidoreductase activity
AKO66_RS17190	COG0657	acetylesterase activity
AKO66_RS17195	COG0477	Major facilitator Superfamily
AKO66_RS17210	COG0789	Transcriptional regulator
AKO66_RS17215	COG1064	alcohol dehydrogenase
AKO66_RS17220	COG1329	Transcriptional regulator
AKO66_RS17225	COG1278	Cold shock
AKO66_RS17230	COG1404	Belongs to the peptidase S8 family
AKO66_RS17240	COG0433	COG0433 Predicted ATPase
AKO66_RS17280	COG3091	SprT-like family
AKO66_RS17285	COG2183	response to ionizing radiation
AKO66_RS17290	COG2208	phosphoserine phosphatase activity
AKO66_RS17295	COG1191	sigma factor activity
AKO66_RS17300	COG2172	sigma factor antagonist activity
AKO66_RS17305	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_RS17310	COG2208	phosphoserine phosphatase activity
AKO66_RS17315	COG2172	sigma factor antagonist activity
AKO66_RS17320	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_RS17325	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_RS17330	COG2337	Toxic component of a toxin-antitoxin (TA) module
AKO66_RS17335	COG0864	Transcriptional regulator
AKO66_RS17340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKO66_RS17345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AKO66_RS17350	COG0736	holo-[acyl-carrier-protein] synthase activity
AKO66_RS17355	COG0705	Rhomboid family
AKO66_RS17360	COG3428	Bacterial PH domain
AKO66_RS17365	COG3402	PFAM membrane-flanked domain
AKO66_RS17370	COG0513	Belongs to the DEAD box helicase family
AKO66_RS17385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKO66_RS17390	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKO66_RS17395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_RS17410	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AKO66_RS17415	COG1131	(ABC) transporter
AKO66_RS17420	COG1301	dicarboxylic acid transport
AKO66_RS17425	COG0628	permease
AKO66_RS17430	COG1301	dicarboxylic acid transport
AKO66_RS17435	COG4565	transcriptional regulatory protein
AKO66_RS17440	COG3290	protein histidine kinase activity
AKO66_RS17445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKO66_RS17450	COG2217	Heavy metal translocating P-type atpase
AKO66_RS17455	COG2261	transglycosylase associated protein
AKO66_RS17460	COG1914	H( )-stimulated, divalent metal cation uptake system
AKO66_RS17465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO66_RS17485	COG5444	nuclease activity
AKO66_RS17490	COG0028	Belongs to the TPP enzyme family
AKO66_RS17495	COG0531	amino acid
AKO66_RS17505	COG1215	transferase activity, transferring glycosyl groups
AKO66_RS17510	COG5298	Protein conserved in bacteria
AKO66_RS17515	COG3706	GGDEF domain
AKO66_RS17520	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AKO66_RS17525	COG0551	DNA topoisomerase type I activity
AKO66_RS17525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKO66_RS17530	COG2814	Major facilitator Superfamily
AKO66_RS17550	COG3871	stress protein (general stress protein 26)
AKO66_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS17560	COG2226	methyltransferase
AKO66_RS17565	COG3711	transcriptional antiterminator
AKO66_RS17575	COG2755	lipolytic protein G-D-S-L family
AKO66_RS17580	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKO66_RS17585	COG1414	Transcriptional regulator
AKO66_RS17590	COG1984	allophanate hydrolase subunit 2
AKO66_RS17595	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AKO66_RS17600	COG4336	lyase activity
AKO66_RS17605	COG1914	H( )-stimulated, divalent metal cation uptake system
AKO66_RS17610	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AKO66_RS17615	COG0457	Tetratricopeptide repeat
AKO66_RS17630	COG0561	phosphatase activity
AKO66_RS17640	COG0346	lactoylglutathione lyase activity
AKO66_RS17675	COG0840	transmembrane signaling receptor activity
AKO66_RS17680	COG0246	Mannitol dehydrogenase
AKO66_RS17685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS17690	COG2213	PTS system mannitol-specific
AKO66_RS17695	COG1276	copper resistance
AKO66_RS17695	COG2372	response to copper ion
AKO66_RS17700	COG4549	nuclear export factor GLE1
AKO66_RS17705	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKO66_RS17710	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_RS17715	COG0531	amino acid
AKO66_RS17720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AKO66_RS17725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_RS17730	COG0583	DNA-binding transcription factor activity
AKO66_RS17740	COG0640	Transcriptional regulator
AKO66_RS17750	COG1309	transcriptional regulator
AKO66_RS17755	COG2814	Major facilitator Superfamily
AKO66_RS17760	COG0527	aspartate kinase activity
AKO66_RS17765	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_RS17770	COG3850	Histidine kinase
AKO66_RS17770	COG5002	protein histidine kinase activity
AKO66_RS17775	COG0745	RESPONSE REGULATOR receiver
AKO66_RS17790	COG2079	MmgE PrpD family protein
AKO66_RS17795	COG1473	amidohydrolase
AKO66_RS17800	COG1126	abc transporter atp-binding protein
AKO66_RS17805	COG0765	amino acid transport
AKO66_RS17810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_RS17815	COG0456	acetyltransferase
AKO66_RS17820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO66_RS17825	COG5434	Belongs to the glycosyl hydrolase 28 family
AKO66_RS17830	COG3104	oligopeptide transport
AKO66_RS17835	COG0833	amino acid
AKO66_RS17840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_RS17845	COG0765	amino acid transport
AKO66_RS17850	COG1126	abc transporter atp-binding protein
AKO66_RS17855	COG2364	Membrane
AKO66_RS17865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_RS17870	COG0697	spore germination
AKO66_RS17875	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AKO66_RS17890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO66_RS17895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO66_RS17900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO66_RS17910	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKO66_RS17915	COG3842	ATPase activity
AKO66_RS17940	COG3209	COG3209 Rhs family protein
AKO66_RS17945	COG3290	protein histidine kinase activity
AKO66_RS17945	COG0840	transmembrane signaling receptor activity
AKO66_RS17955	COG2746	aminoglycoside 3-N-acetyltransferase activity
AKO66_RS17960	COG1522	sequence-specific DNA binding
AKO66_RS17965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKO66_RS17975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_RS17980	COG0765	amino acid transport
AKO66_RS17985	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKO66_RS17990	COG2508	Transcriptional regulator
AKO66_RS17995	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_RS18000	COG0506	proline dehydrogenase activity
AKO66_RS18005	COG3541	Predicted nucleotidyltransferase
AKO66_RS18015	COG3458	cephalosporin-C deacetylase activity
AKO66_RS18020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKO66_RS18025	COG0583	DNA-binding transcription factor activity
AKO66_RS18030	COG2226	methyltransferase
AKO66_RS18035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKO66_RS18050	COG2271	Major facilitator Superfamily
AKO66_RS18055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKO66_RS18065	COG0028	Belongs to the TPP enzyme family
AKO66_RS18070	COG0710	3-dehydroquinate dehydratase activity
AKO66_RS18075	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_RS18085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKO66_RS18090	COG3665	Urea carboxylase-associated protein
AKO66_RS18095	COG1113	amino acid transport
AKO66_RS18100	COG3403	YqcI/YcgG family
AKO66_RS18115	COG1280	lysine exporter protein (LysE YggA)
AKO66_RS18120	COG0738	Major facilitator superfamily
AKO66_RS18125	COG0673	inositol 2-dehydrogenase activity
AKO66_RS18130	COG0561	phosphatase activity
AKO66_RS18135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO66_RS18140	COG1609	Transcriptional regulator
AKO66_RS18145	COG1620	l-lactate permease
AKO66_RS18150	COG0039	L-malate dehydrogenase activity
AKO66_RS18155	COG1288	antiporter activity
AKO66_RS18160	COG1473	amidohydrolase
AKO66_RS18175	COG2113	Glycine betaine
AKO66_RS18180	COG4176	ABC-type proline glycine betaine transport system permease component
AKO66_RS18185	COG4175	Glycine betaine
AKO66_RS18185	COG0517	IMP dehydrogenase activity
AKO66_RS18190	COG3853	Toxic anion resistance protein (TelA)
AKO66_RS18220	COG0861	Integral membrane protein TerC family
AKO66_RS18225	COG2310	stress, protein
AKO66_RS18230	COG2310	stress, protein
AKO66_RS18235	COG2310	stress, protein
AKO66_RS18240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO66_RS18250	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_RS18255	COG3773	Cell wall hydrolase
AKO66_RS18270	COG1668	transmembrane transport
AKO66_RS18275	COG4555	ABC transporter
AKO66_RS18280	COG3279	Response regulator of the LytR AlgR family
AKO66_RS18285	COG3290	protein histidine kinase activity
AKO66_RS18290	COG0667	Aldo Keto reductase
AKO66_RS18300	COG4585	Histidine kinase
AKO66_RS18305	COG2197	response regulator
AKO66_RS18315	COG1405	negative regulation of cell septum assembly
AKO66_RS18315	COG3012	SEC-C Motif Domain Protein
AKO66_RS18320	COG0784	Response regulator, receiver
AKO66_RS18325	COG4191	Histidine kinase
AKO66_RS18330	COG2066	Belongs to the glutaminase family
AKO66_RS18335	COG1115	amino acid carrier protein
AKO66_RS18340	COG0596	Alpha beta hydrolase
AKO66_RS18350	COG0531	amino acid
AKO66_RS18355	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_RS18360	COG1846	Transcriptional regulator
AKO66_RS18365	COG1063	alcohol dehydrogenase
AKO66_RS18370	COG1917	Cupin 2, conserved barrel domain protein
AKO66_RS18375	COG1309	transcriptional regulator
AKO66_RS18385	COG1404	Belongs to the peptidase S8 family
AKO66_RS18400	COG0456	acetyltransferase
AKO66_RS18405	COG2814	Major facilitator Superfamily
AKO66_RS18415	COG1695	Transcriptional regulator
AKO66_RS18420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_RS18425	COG2040	homocysteine
AKO66_RS18430	COG0833	amino acid
AKO66_RS18440	COG1404	Belongs to the peptidase S8 family
AKO66_RS18450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_RS18455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_RS18460	COG0383	alpha-mannosidase activity
AKO66_RS18465	COG1940	carbohydrate kinase activity
AKO66_RS18470	COG3711	transcriptional antiterminator
AKO66_RS18470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_RS18485	COG2723	6-phospho-beta-galactosidase activity
AKO66_RS18490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS18490	COG1263	PTS System
AKO66_RS18490	COG2190	(PTS) system
AKO66_RS18495	COG3711	transcriptional antiterminator
AKO66_RS18505	COG0531	amino acid
AKO66_RS18510	COG1054	Belongs to the UPF0176 family
AKO66_RS18515	COG0371	Dehydrogenase
AKO66_RS18520	COG0656	L-ascorbic acid biosynthetic process
AKO66_RS18530	COG1683	Conserved Protein
AKO66_RS18540	COG1846	Transcriptional regulator
AKO66_RS18555	COG2814	Major facilitator Superfamily
AKO66_RS18560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKO66_RS18565	COG0730	response to heat
AKO66_RS18570	COG0425	Belongs to the sulfur carrier protein TusA family
AKO66_RS18575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO66_RS18575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_RS18580	COG0425	Belongs to the sulfur carrier protein TusA family
AKO66_RS18580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO66_RS18590	COG2210	Belongs to the sulfur carrier protein TusA family
AKO66_RS18595	COG1937	Protein conserved in bacteria
AKO66_RS18610	COG0640	Transcriptional regulator
AKO66_RS18620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKO66_RS18625	COG1331	Highly conserved protein containing a thioredoxin domain
AKO66_RS18635	COG2271	Major facilitator Superfamily
AKO66_RS18640	COG0584	glycerophosphoryl diester phosphodiesterase
AKO66_RS18645	COG1113	amino acid transport
AKO66_RS18660	COG1309	transcriptional regulator
AKO66_RS18665	COG2207	Transcriptional regulator
AKO66_RS18670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKO66_RS18680	COG1476	TRANSCRIPTIONal
AKO66_RS18700	COG2311	Membrane
AKO66_RS18710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_RS18715	COG1413	lyase activity
AKO66_RS18725	COG1131	(ABC) transporter
AKO66_RS18730	COG1266	CAAX protease self-immunity
AKO66_RS18735	COG0535	radical SAM domain protein
AKO66_RS18750	COG1695	Transcriptional regulator
AKO66_RS18760	COG1136	(ABC) transporter
AKO66_RS18770	COG1131	(ABC) transporter
AKO66_RS18790	COG3852	Histidine kinase
AKO66_RS18795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKO66_RS18800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKO66_RS18805	COG4856	YbbR-like protein
AKO66_RS18810	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKO66_RS18815	COG5662	AntiSigma factor
AKO66_RS18820	COG1595	DNA-templated transcription, initiation
AKO66_RS18855	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AKO66_RS18860	COG1737	Transcriptional regulator
AKO66_RS18865	COG1263	PTS System
AKO66_RS18865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_RS18870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AKO66_RS18875	COG1472	Belongs to the glycosyl hydrolase 3 family
AKO66_RS18880	COG3876	Protein conserved in bacteria
AKO66_RS18885	COG0385	Bile acid
AKO66_RS18890	COG0659	secondary active sulfate transmembrane transporter activity
AKO66_RS18895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_RS18935	COG0726	polysaccharide deacetylase
AKO66_RS18940	COG2194	sulfuric ester hydrolase activity
AKO66_RS18950	COG0489	protein tyrosine kinase activity
AKO66_RS18955	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_RS18980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO66_RS18985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKO66_RS18990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKO66_RS18995	COG0101	tRNA pseudouridine synthase activity
AKO66_RS19000	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO66_RS19005	COG1122	ATPase activity
AKO66_RS19010	COG1122	ATPase activity
AKO66_RS19015	COG0203	ribosomal protein L17
AKO66_RS19020	COG0202	RNA polymerase activity
AKO66_RS19025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKO66_RS19030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKO66_RS19035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKO66_RS19040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKO66_RS19045	COG0024	Methionine aminopeptidase
AKO66_RS19050	COG0563	adenylate kinase activity
AKO66_RS19055	COG0201	protein transport
AKO66_RS19060	COG0200	Binds to the 23S rRNA
AKO66_RS19065	COG1841	ribosomal large subunit assembly
AKO66_RS19070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKO66_RS19075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKO66_RS19080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKO66_RS19085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKO66_RS19090	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKO66_RS19095	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKO66_RS19100	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKO66_RS19105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKO66_RS19110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKO66_RS19115	COG0255	Belongs to the universal ribosomal protein uL29 family
AKO66_RS19120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKO66_RS19125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKO66_RS19130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKO66_RS19135	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKO66_RS19140	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKO66_RS19145	COG0089	rRNA binding
AKO66_RS19150	COG0088	Forms part of the polypeptide exit tunnel
AKO66_RS19155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKO66_RS19165	COG0596	Alpha beta hydrolase
AKO66_RS19170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKO66_RS19175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKO66_RS19180	COG0049	tRNA binding
AKO66_RS19185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKO66_RS19190	COG1358	cellular component organization or biogenesis
AKO66_RS19195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKO66_RS19200	COG0085	RNA polymerase activity
AKO66_RS19205	COG2813	Specifically methylates the guanine in position
AKO66_RS19210	COG0222	ribosome binding
AKO66_RS19215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKO66_RS19220	COG0081	regulation of translation
AKO66_RS19230	COG0250	Participates in transcription elongation, termination and antitermination
AKO66_RS19235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKO66_RS19240	COG1595	DNA-templated transcription, initiation
AKO66_RS19245	COG3688	RNA-binding protein containing a PIN domain
AKO66_RS19250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKO66_RS19255	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AKO66_RS19260	COG0215	cysteine-tRNA ligase activity
AKO66_RS19265	COG1045	serine acetyltransferase
AKO66_RS19270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKO66_RS19275	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKO66_RS19280	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKO66_RS19285	COG4956	integral membrane protein (PIN domain superfamily)
AKO66_RS19290	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AKO66_RS19295	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AKO66_RS19300	COG0542	response to heat
AKO66_RS19305	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AKO66_RS19310	COG3880	PFAM UvrB UvrC protein
AKO66_RS19315	COG4463	regulation of RNA biosynthetic process