locus-tag	class	description
HZ310_RS00020	COG4720	Psort location CytoplasmicMembrane, score
HZ310_RS00030	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZ310_RS00040	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZ310_RS00070	COG0640	Transcriptional regulator
HZ310_RS00075	COG2814	Major facilitator Superfamily
HZ310_RS00085	COG2409	Drug exporters of the RND superfamily
HZ310_RS00095	COG3850	Histidine kinase
HZ310_RS00095	COG5002	protein histidine kinase activity
HZ310_RS00110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZ310_RS00130	COG0583	DNA-binding transcription factor activity
HZ310_RS00135	COG0384	phenazine biosynthesis protein PhzF
HZ310_RS00150	COG2188	Transcriptional regulator
HZ310_RS00155	COG2723	6-phospho-beta-galactosidase activity
HZ310_RS00160	COG2814	Major facilitator Superfamily
HZ310_RS00170	COG2814	Major facilitator Superfamily
HZ310_RS00180	COG1113	amino acid transport
HZ310_RS00220	COG2190	(PTS) system
HZ310_RS00220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS00220	COG1263	PTS System
HZ310_RS00225	COG2723	6-phospho-beta-galactosidase activity
HZ310_RS00230	COG3711	transcriptional antiterminator
HZ310_RS00235	COG0457	Tetratricopeptide repeat
HZ310_RS00245	COG1136	(ABC) transporter
HZ310_RS00255	COG2814	Major facilitator Superfamily
HZ310_RS00260	COG1309	transcriptional regulator
HZ310_RS00265	COG3835	regulator
HZ310_RS00270	COG2610	gluconate transmembrane transporter activity
HZ310_RS00275	COG1929	Belongs to the glycerate kinase type-1 family
HZ310_RS00280	COG2824	Alkylphosphonate utilization operon protein PhnA
HZ310_RS00285	COG1131	(ABC) transporter
HZ310_RS00290	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HZ310_RS00300	COG2851	Citrate transporter
HZ310_RS00305	COG1874	Beta-galactosidase
HZ310_RS00315	COG3833	ABC-type maltose transport systems, permease component
HZ310_RS00320	COG1175	transmembrane transport
HZ310_RS00325	COG2182	Extracellular solute-binding protein
HZ310_RS00330	COG1609	Transcriptional regulator
HZ310_RS00335	COG0583	DNA-binding transcription factor activity
HZ310_RS00365	COG1957	nucleoside hydrolase
HZ310_RS00370	COG1737	Transcriptional regulator
HZ310_RS00375	COG1070	Carbohydrate kinase
HZ310_RS00385	COG4335	DNA alkylation repair
HZ310_RS00390	COG1113	amino acid transport
HZ310_RS00395	COG0840	transmembrane signaling receptor activity
HZ310_RS00400	COG0673	inositol 2-dehydrogenase activity
HZ310_RS00405	COG0789	Transcriptional regulator
HZ310_RS00410	COG0561	phosphatase activity
HZ310_RS00435	COG0477	Major facilitator Superfamily
HZ310_RS00440	COG2755	lipolytic protein G-D-S-L family
HZ310_RS00440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZ310_RS00450	COG2390	Transcriptional regulator
HZ310_RS00455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HZ310_RS00460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZ310_RS00465	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HZ310_RS00470	COG1846	Transcriptional regulator
HZ310_RS00475	COG0778	Nitroreductase
HZ310_RS00480	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HZ310_RS00515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HZ310_RS00520	COG4721	ABC-type cobalt transport system, permease component
HZ310_RS00525	COG1122	ATPase activity
HZ310_RS00530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZ310_RS00540	COG3878	Protein conserved in bacteria
HZ310_RS00545	COG3711	transcriptional antiterminator
HZ310_RS00550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS00550	COG2190	(PTS) system
HZ310_RS00550	COG1263	PTS System
HZ310_RS00555	COG2723	6-phospho-beta-galactosidase activity
HZ310_RS00560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HZ310_RS00565	COG2610	gluconate transmembrane transporter activity
HZ310_RS00575	COG2084	Dehydrogenase
HZ310_RS00580	COG1737	Transcriptional regulator
HZ310_RS00595	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZ310_RS00600	COG4842	Belongs to the WXG100 family
HZ310_RS00625	COG1396	sequence-specific DNA binding
HZ310_RS00630	COG0252	asparaginase activity
HZ310_RS00635	COG1027	Aspartate ammonia-lyase
HZ310_RS00640	COG1757	Na H antiporter
HZ310_RS00665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS00665	COG3711	transcriptional antiterminator
HZ310_RS00670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ310_RS00680	COG2723	6-phospho-beta-galactosidase activity
HZ310_RS00685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ310_RS00690	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZ310_RS00695	COG0726	polysaccharide deacetylase
HZ310_RS00700	COG0346	lactoylglutathione lyase activity
HZ310_RS00705	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ310_RS00705	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ310_RS00710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ310_RS00710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ310_RS00715	COG2514	catechol 2,3-dioxygenase activity
HZ310_RS00720	COG1733	regulation of RNA biosynthetic process
HZ310_RS00725	COG5386	Cell surface protein
HZ310_RS00730	COG5386	Cell surface protein
HZ310_RS00755	COG4509	Sortase family
HZ310_RS00775	COG1271	oxidase subunit
HZ310_RS00780	COG1294	oxidase, subunit
HZ310_RS00785	COG4988	ABC transporter
HZ310_RS00790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HZ310_RS00800	COG1595	DNA-templated transcription, initiation
HZ310_RS00815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZ310_RS00830	COG3711	transcriptional antiterminator
HZ310_RS00830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS00835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ310_RS00840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ310_RS00845	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZ310_RS00850	COG1486	melibiose metabolic process
HZ310_RS00860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZ310_RS00865	COG3420	alginic acid biosynthetic process
HZ310_RS00875	COG1129	ABC transporter
HZ310_RS00880	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZ310_RS00885	COG2357	RelA SpoT domain protein
HZ310_RS00895	COG0457	Tetratricopeptide repeat
HZ310_RS00900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ310_RS00905	COG0765	amino acid transport
HZ310_RS00915	COG0346	lactoylglutathione lyase activity
HZ310_RS00920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZ310_RS00925	COG1346	cytolysis
HZ310_RS00935	COG0583	DNA-binding transcription factor activity
HZ310_RS00940	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HZ310_RS00945	COG0352	thiamine-phosphate diphosphorylase activity
HZ310_RS00970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZ310_RS00975	COG3162	membrane
HZ310_RS00995	COG2246	polysaccharide biosynthetic process
HZ310_RS01010	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HZ310_RS01015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZ310_RS01020	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HZ310_RS01030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZ310_RS01035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZ310_RS01040	COG1845	cytochrome c oxidase, subunit III
HZ310_RS01045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HZ310_RS01055	COG0772	Belongs to the SEDS family
HZ310_RS01060	COG0778	Nitroreductase
HZ310_RS01065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ310_RS01070	COG1404	Belongs to the peptidase S8 family
HZ310_RS01080	COG3711	transcriptional antiterminator
HZ310_RS01085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS01085	COG1263	PTS System
HZ310_RS01090	COG1621	beta-fructofuranosidase activity
HZ310_RS01105	COG0351	phosphomethylpyrimidine kinase
HZ310_RS01115	COG1216	Glycosyl transferase, family 2
HZ310_RS01120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZ310_RS01125	COG1012	belongs to the aldehyde dehydrogenase family
HZ310_RS01135	COG2233	PERMEase
HZ310_RS01140	COG2363	Small membrane protein
HZ310_RS01160	COG0463	Glycosyl transferase, family 2
HZ310_RS01165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZ310_RS01170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZ310_RS01175	COG0456	acetyltransferase
HZ310_RS01180	COG2089	acid synthase
HZ310_RS01185	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HZ310_RS01190	COG3980	spore coat polysaccharide biosynthesis protein
HZ310_RS01195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HZ310_RS01200	COG1088	dTDP-glucose 4,6-dehydratase activity
HZ310_RS01205	COG1091	dTDP-4-dehydrorhamnose reductase activity
HZ310_RS01210	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HZ310_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS01220	COG0436	Aminotransferase
HZ310_RS01225	COG0151	Belongs to the GarS family
HZ310_RS01230	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS01235	COG1917	Cupin 2, conserved barrel domain protein
HZ310_RS01240	COG0077	Prephenate dehydratase
HZ310_RS01245	COG2814	Major facilitator Superfamily
HZ310_RS01250	COG1522	sequence-specific DNA binding
HZ310_RS01270	COG0280	phosphate acetyltransferase
HZ310_RS01280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HZ310_RS01310	COG5444	nuclease activity
HZ310_RS01350	COG4844	belongs to the
HZ310_RS01355	COG1078	dGTPase activity
HZ310_RS01360	COG3465	dGTPase activity
HZ310_RS01385	COG1131	(ABC) transporter
HZ310_RS01390	COG1942	4-Oxalocrotonate Tautomerase
HZ310_RS01395	COG1994	Peptidase M50
HZ310_RS01405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ310_RS01410	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZ310_RS01415	COG0010	Belongs to the arginase family
HZ310_RS01425	COG4506	Protein conserved in bacteria
HZ310_RS01430	COG0018	arginyl-trna synthetase
HZ310_RS01440	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZ310_RS01445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ310_RS01450	COG1132	(ABC) transporter
HZ310_RS01455	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZ310_RS01465	COG4294	response to UV
HZ310_RS01470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ310_RS01475	COG2181	nitrate reductase activity
HZ310_RS01475	COG0247	lactate metabolic process
HZ310_RS01480	COG0183	Belongs to the thiolase family
HZ310_RS01485	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ310_RS01490	COG1960	acyl-CoA dehydrogenase activity
HZ310_RS01495	COG1960	acyl-CoA dehydrogenase activity
HZ310_RS01530	COG3343	RNA polymerase activity
HZ310_RS01535	COG0504	CTP synthase activity
HZ310_RS01540	COG4821	SIS domain
HZ310_RS01545	COG2204	response regulator
HZ310_RS01550	COG0191	fructose-bisphosphate aldolase activity
HZ310_RS01555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZ310_RS01560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZ310_RS01565	COG1494	fructose-1,6-bisphosphatase
HZ310_RS01570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZ310_RS01575	COG0254	rRNA binding
HZ310_RS01580	COG1435	thymidine kinase activity
HZ310_RS01585	COG0281	malic enzyme
HZ310_RS01590	COG0679	Auxin Efflux Carrier
HZ310_RS01595	COG0789	Transcriptional regulator
HZ310_RS01600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZ310_RS01605	COG2890	protein-(glutamine-N5) methyltransferase activity
HZ310_RS01620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HZ310_RS01625	COG0009	L-threonylcarbamoyladenylate synthase
HZ310_RS01630	COG1971	Probably functions as a manganese efflux pump
HZ310_RS01635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ310_RS01640	COG0698	ribose 5-phosphate isomerase
HZ310_RS01645	COG4475	Protein of unknown function (DUF436)
HZ310_RS01650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZ310_RS01655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZ310_RS01665	COG0356	it plays a direct role in the translocation of protons across the membrane
HZ310_RS01670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZ310_RS01675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZ310_RS01680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZ310_RS01685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZ310_RS01690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HZ310_RS01695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZ310_RS01700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZ310_RS01710	COG4836	Membrane
HZ310_RS01720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZ310_RS01725	COG2385	sporulation resulting in formation of a cellular spore
HZ310_RS01730	COG2304	oxidoreductase activity
HZ310_RS01735	COG2304	oxidoreductase activity
HZ310_RS01740	COG0243	molybdopterin cofactor binding
HZ310_RS01745	COG2223	nitrite transmembrane transporter activity
HZ310_RS01750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HZ310_RS01755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZ310_RS01760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZ310_RS01765	COG0523	cobalamin synthesis protein
HZ310_RS01770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZ310_RS01810	COG1247	-acetyltransferase
HZ310_RS01815	COG0739	heme binding
HZ310_RS01820	COG0347	Belongs to the P(II) protein family
HZ310_RS01825	COG0004	ammonium transporteR
HZ310_RS01835	COG0765	amino acid transport
HZ310_RS01840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ310_RS01845	COG0477	Major facilitator Superfamily
HZ310_RS01850	COG0671	phosphoesterase, PA-phosphatase related
HZ310_RS01855	COG2814	Major facilitator Superfamily
HZ310_RS01860	COG1846	Transcriptional regulator
HZ310_RS01865	COG1609	Transcriptional regulator
HZ310_RS01870	COG1077	Cell shape determining protein MreB Mrl
HZ310_RS01875	COG4786	Flagellar basal body rod
HZ310_RS01880	COG4786	Flagellar basal body rod
HZ310_RS01885	COG0457	Tetratricopeptide repeat
HZ310_RS01890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZ310_RS01895	COG1970	mechanosensitive ion channel activity
HZ310_RS01910	COG0561	phosphatase activity
HZ310_RS01915	COG2202	Pas domain
HZ310_RS01915	COG1366	Belongs to the anti-sigma-factor antagonist family
HZ310_RS01920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ310_RS01925	COG4715	Zinc finger, swim domain protein
HZ310_RS01935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZ310_RS01940	COG2059	Chromate
HZ310_RS01945	COG2059	Chromate
HZ310_RS01950	COG1522	sequence-specific DNA binding
HZ310_RS01955	COG3527	Alpha-acetolactate decarboxylase
HZ310_RS01960	COG0028	Belongs to the TPP enzyme family
HZ310_RS01965	COG0583	DNA-binding transcription factor activity
HZ310_RS01970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZ310_RS01975	COG1879	ABC-type sugar transport system periplasmic component
HZ310_RS01980	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZ310_RS01985	COG1129	ABC transporter
HZ310_RS01990	COG1869	D-ribose catabolic process
HZ310_RS01995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZ310_RS02000	COG1609	Transcriptional regulator
HZ310_RS02015	COG0697	spore germination
HZ310_RS02020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZ310_RS02030	COG2843	Capsule synthesis protein
HZ310_RS02040	COG0791	NLP P60 protein
HZ310_RS02045	COG0561	phosphatase activity
HZ310_RS02050	COG1316	TRANSCRIPTIONal
HZ310_RS02055	COG2814	Major facilitator Superfamily
HZ310_RS02070	COG0814	amino acid
HZ310_RS02075	COG0697	spore germination
HZ310_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS02085	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HZ310_RS02090	COG1609	Transcriptional regulator
HZ310_RS02095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZ310_RS02100	COG0800	Aldolase
HZ310_RS02105	COG0454	-acetyltransferase
HZ310_RS02115	COG2972	Histidine kinase
HZ310_RS02120	COG2197	response regulator
HZ310_RS02125	COG1653	transport
HZ310_RS02130	COG1175	transmembrane transport
HZ310_RS02140	COG1482	cell wall glycoprotein biosynthetic process
HZ310_RS02145	COG4193	domain, Protein
HZ310_RS02150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZ310_RS02155	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZ310_RS02160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZ310_RS02170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZ310_RS02175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HZ310_RS02175	COG0463	Glycosyl transferase, family 2
HZ310_RS02180	COG1682	transport, permease protein
HZ310_RS02185	COG1134	teichoic acid transport
HZ310_RS02190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZ310_RS02195	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HZ310_RS02205	COG1316	TRANSCRIPTIONal
HZ310_RS02215	COG2385	sporulation resulting in formation of a cellular spore
HZ310_RS02215	COG2247	cell wall binding repeat
HZ310_RS02220	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ310_RS02220	COG2247	cell wall binding repeat
HZ310_RS02235	COG2244	polysaccharide biosynthetic process
HZ310_RS02240	COG0438	transferase activity, transferring glycosyl groups
HZ310_RS02240	COG0297	glycogen (starch) synthase activity
HZ310_RS02245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZ310_RS02250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ310_RS02255	COG3307	-O-antigen
HZ310_RS02260	COG3206	protein involved in exopolysaccharide biosynthesis
HZ310_RS02265	COG1215	transferase activity, transferring glycosyl groups
HZ310_RS02270	COG0438	transferase activity, transferring glycosyl groups
HZ310_RS02275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZ310_RS02280	COG1316	TRANSCRIPTIONal
HZ310_RS02285	COG1739	Uncharacterized protein family UPF0029
HZ310_RS02290	COG4585	Histidine kinase
HZ310_RS02295	COG2197	response regulator
HZ310_RS02300	COG1307	EDD domain protein, DegV family
HZ310_RS02305	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HZ310_RS02315	COG1040	competence protein
HZ310_RS02330	COG3418	PFAM FlgN family protein
HZ310_RS02335	COG4786	Flagellar basal body rod
HZ310_RS02335	COG1256	bacterial-type flagellum assembly
HZ310_RS02340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZ310_RS02350	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HZ310_RS02355	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZ310_RS02360	COG1334	flagellar protein FlaG
HZ310_RS02365	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HZ310_RS02370	COG1516	flagellar protein fliS
HZ310_RS02385	COG0840	transmembrane signaling receptor activity
HZ310_RS02390	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZ310_RS02415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ310_RS02420	COG2010	Cytochrome c
HZ310_RS02425	COG2884	Cell division ATP-binding protein ftsE
HZ310_RS02430	COG2177	Part of the ABC transporter FtsEX involved in
HZ310_RS02435	COG3883	PFAM NLP P60 protein
HZ310_RS02435	COG0791	NLP P60 protein
HZ310_RS02440	COG0730	response to heat
HZ310_RS02445	COG0793	Belongs to the peptidase S41A family
HZ310_RS02445	COG3409	Peptidoglycan-binding domain 1 protein
HZ310_RS02455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ310_RS02460	COG1733	regulation of RNA biosynthetic process
HZ310_RS02465	COG0778	Nitroreductase
HZ310_RS02470	COG1113	amino acid transport
HZ310_RS02475	COG0463	Glycosyl transferase, family 2
HZ310_RS02480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZ310_RS02485	COG5002	protein histidine kinase activity
HZ310_RS02490	COG0745	RESPONSE REGULATOR receiver
HZ310_RS02500	COG2814	Major facilitator Superfamily
HZ310_RS02505	COG1309	transcriptional regulator
HZ310_RS02510	COG3848	Pyruvate phosphate dikinase
HZ310_RS02510	COG0574	Belongs to the PEP-utilizing enzyme family
HZ310_RS02515	COG4897	Protein conserved in bacteria
HZ310_RS02525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZ310_RS02540	COG3595	metallopeptidase activity
HZ310_RS02545	COG1983	PspC domain protein
HZ310_RS02550	COG1950	PFAM Membrane protein of
HZ310_RS02555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZ310_RS02565	COG2188	Transcriptional regulator
HZ310_RS02570	COG0363	glucosamine-6-phosphate deaminase activity
HZ310_RS02575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZ310_RS02580	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZ310_RS02585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZ310_RS02590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HZ310_RS02595	COG0546	phosphoglycolate phosphatase activity
HZ310_RS02600	COG0110	maltose O-acetyltransferase activity
HZ310_RS02605	COG1959	2 iron, 2 sulfur cluster binding
HZ310_RS02610	COG2910	NAD(P)H-binding
HZ310_RS02620	COG4990	cell redox homeostasis
HZ310_RS02625	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HZ310_RS02630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HZ310_RS02635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HZ310_RS02640	COG0131	Imidazoleglycerol-phosphate dehydratase
HZ310_RS02645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZ310_RS02650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HZ310_RS02655	COG0107	imidazoleglycerol-phosphate synthase activity
HZ310_RS02660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZ310_RS02660	COG0140	phosphoribosyl-ATP diphosphatase activity
HZ310_RS02665	COG0457	Tetratricopeptide repeat
HZ310_RS02670	COG0791	NLP P60 protein
HZ310_RS02670	COG3883	PFAM NLP P60 protein
HZ310_RS02675	COG0492	ferredoxin-NADP+ reductase activity
HZ310_RS02680	COG1051	belongs to the nudix hydrolase family
HZ310_RS02685	COG1660	Displays ATPase and GTPase activities
HZ310_RS02690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZ310_RS02695	COG1481	regulation of sporulation
HZ310_RS02700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS02705	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HZ310_RS02715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ310_RS02720	COG0288	reversible hydration of carbon dioxide
HZ310_RS02725	COG0659	secondary active sulfate transmembrane transporter activity
HZ310_RS02730	COG1694	Mazg nucleotide pyrophosphohydrolase
HZ310_RS02735	COG1611	Belongs to the LOG family
HZ310_RS02740	COG0740	serine-type endopeptidase activity
HZ310_RS02755	COG1819	glycosyl
HZ310_RS02765	COG0726	polysaccharide deacetylase
HZ310_RS02770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ310_RS02775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ310_RS02780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ310_RS02795	COG1396	sequence-specific DNA binding
HZ310_RS02800	COG3944	biosynthesis protein
HZ310_RS02805	COG0489	protein tyrosine kinase activity
HZ310_RS02810	COG1086	Polysaccharide biosynthesis protein
HZ310_RS02815	COG0438	transferase activity, transferring glycosyl groups
HZ310_RS02820	COG1215	transferase activity, transferring glycosyl groups
HZ310_RS02825	COG0438	transferase activity, transferring glycosyl groups
HZ310_RS02835	COG1216	Glycosyl transferase, family 2
HZ310_RS02840	COG5039	Polysaccharide pyruvyl transferase
HZ310_RS02845	COG2244	polysaccharide biosynthetic process
HZ310_RS02850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZ310_RS02855	COG0110	maltose O-acetyltransferase activity
HZ310_RS02860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZ310_RS02865	COG0747	negative chemotaxis
HZ310_RS02870	COG0601	transmembrane transport
HZ310_RS02875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ310_RS02880	COG0444	Belongs to the ABC transporter superfamily
HZ310_RS02885	COG4608	Belongs to the ABC transporter superfamily
HZ310_RS02890	COG0534	Mate efflux family protein
HZ310_RS02900	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HZ310_RS02905	COG2186	Transcriptional regulator
HZ310_RS02910	COG3829	transcription factor binding
HZ310_RS02915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZ310_RS02920	COG0833	amino acid
HZ310_RS02925	COG2390	Transcriptional regulator
HZ310_RS02930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZ310_RS02935	COG0126	phosphoglycerate kinase activity
HZ310_RS02940	COG0149	triose-phosphate isomerase activity
HZ310_RS02945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HZ310_RS02950	COG0148	phosphopyruvate hydratase activity
HZ310_RS02960	COG1131	(ABC) transporter
HZ310_RS02980	COG0456	acetyltransferase
HZ310_RS02990	COG2095	MarC family integral membrane protein
HZ310_RS02995	COG1510	regulation of RNA biosynthetic process
HZ310_RS03000	COG0517	IMP dehydrogenase activity
HZ310_RS03000	COG1125	glycine betaine transport
HZ310_RS03005	COG1174	glycine betaine transport
HZ310_RS03010	COG1732	Glycine betaine
HZ310_RS03015	COG1174	glycine betaine transport
HZ310_RS03020	COG1733	regulation of RNA biosynthetic process
HZ310_RS03025	COG1396	sequence-specific DNA binding
HZ310_RS03030	COG1396	sequence-specific DNA binding
HZ310_RS03035	COG1476	TRANSCRIPTIONal
HZ310_RS03040	COG2002	toxin-antitoxin pair type II binding
HZ310_RS03045	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZ310_RS03050	COG1647	Serine aminopeptidase, S33
HZ310_RS03055	COG0557	exoribonuclease II activity
HZ310_RS03060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZ310_RS03070	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZ310_RS03090	COG1937	Protein conserved in bacteria
HZ310_RS03095	COG2608	mercury ion transmembrane transporter activity
HZ310_RS03100	COG2217	Heavy metal translocating P-type atpase
HZ310_RS03110	COG1027	Aspartate ammonia-lyase
HZ310_RS03115	COG4191	Histidine kinase
HZ310_RS03120	COG0784	Response regulator, receiver
HZ310_RS03125	COG3226	Transcriptional regulator
HZ310_RS03135	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZ310_RS03140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ310_RS03145	COG1121	(ABC) transporter
HZ310_RS03150	COG2217	Heavy metal translocating P-type atpase
HZ310_RS03155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZ310_RS03160	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HZ310_RS03165	COG2860	membrane
HZ310_RS03170	COG0025	NhaP-type Na H and K H
HZ310_RS03175	COG1940	carbohydrate kinase activity
HZ310_RS03180	COG0656	L-ascorbic acid biosynthetic process
HZ310_RS03185	COG4149	molybdate abc transporter
HZ310_RS03190	COG0725	ABC transporter, periplasmic molybdate-binding protein
HZ310_RS03195	COG1368	sulfuric ester hydrolase activity
HZ310_RS03200	COG1988	membrane-bound metal-dependent
HZ310_RS03215	COG0531	amino acid
HZ310_RS03220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ310_RS03225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ310_RS03230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ310_RS03235	COG1120	ATPase activity
HZ310_RS03240	COG0745	RESPONSE REGULATOR receiver
HZ310_RS03245	COG2205	protein histidine kinase activity
HZ310_RS03250	COG1904	glucuronate isomerase
HZ310_RS03255	COG1609	Transcriptional regulator
HZ310_RS03260	COG0246	Mannitol dehydrogenase
HZ310_RS03265	COG2721	sulfolactate sulfo-lyase activity
HZ310_RS03275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ310_RS03280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ310_RS03285	COG1120	ATPase activity
HZ310_RS03290	COG2096	Adenosyltransferase
HZ310_RS03295	COG4758	membrane
HZ310_RS03300	COG1842	Phage shock protein A
HZ310_RS03310	COG4758	membrane
HZ310_RS03315	COG4585	Histidine kinase
HZ310_RS03320	COG2197	response regulator
HZ310_RS03335	COG0814	amino acid
HZ310_RS03340	COG0697	spore germination
HZ310_RS03350	COG0114	fumarate hydratase activity
HZ310_RS03355	COG1309	transcriptional regulator
HZ310_RS03365	COG2770	Histidine kinase
HZ310_RS03365	COG2205	protein histidine kinase activity
HZ310_RS03370	COG0745	RESPONSE REGULATOR receiver
HZ310_RS03375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ310_RS03380	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS03390	COG1120	ATPase activity
HZ310_RS03400	COG5577	PFAM Coat F domain
HZ310_RS03415	COG1024	Enoyl-CoA hydratase
HZ310_RS03415	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ310_RS03420	COG0183	Belongs to the thiolase family
HZ310_RS03425	COG1960	acyl-CoA dehydrogenase activity
HZ310_RS03430	COG1393	Belongs to the ArsC family
HZ310_RS03435	COG0509	glycine decarboxylation via glycine cleavage system
HZ310_RS03445	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HZ310_RS03450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS03460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZ310_RS03465	COG2011	ABC-type metal ion transport system permease component
HZ310_RS03470	COG1464	Belongs to the NlpA lipoprotein family
HZ310_RS03475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZ310_RS03485	COG0396	ATPase activity
HZ310_RS03490	COG0719	Fe-S assembly protein
HZ310_RS03495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZ310_RS03500	COG0822	iron-sulfur transferase activity
HZ310_RS03505	COG0719	Fe-S assembly protein
HZ310_RS03530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZ310_RS03540	COG2311	Membrane
HZ310_RS03545	COG0745	RESPONSE REGULATOR receiver
HZ310_RS03550	COG5002	protein histidine kinase activity
HZ310_RS03550	COG0642	Histidine kinase
HZ310_RS03575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ310_RS03580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ310_RS03585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ310_RS03595	COG2356	endonuclease I
HZ310_RS03600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HZ310_RS03605	COG2814	Major facilitator Superfamily
HZ310_RS03610	COG2140	Oxalate decarboxylase
HZ310_RS03615	COG2508	Transcriptional regulator
HZ310_RS03620	COG1801	Protein of unknown function DUF72
HZ310_RS03625	COG0737	Belongs to the 5'-nucleotidase family
HZ310_RS03630	COG3377	Domain of unknown function (DUF1805)
HZ310_RS03640	COG0739	heme binding
HZ310_RS03645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HZ310_RS03655	COG4470	Protein conserved in bacteria
HZ310_RS03660	COG2445	Protein of unknown function DUF86
HZ310_RS03665	COG0647	UMP catabolic process
HZ310_RS03670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HZ310_RS03675	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZ310_RS03680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ310_RS03685	COG0460	homoserine dehydrogenase
HZ310_RS03690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HZ310_RS03695	COG0083	homoserine kinase activity
HZ310_RS03700	COG4946	Tricorn protease homolog
HZ310_RS03700	COG1506	peptidase
HZ310_RS03700	COG0823	Involved in the tonB-independent uptake of proteins
HZ310_RS03705	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HZ310_RS03710	COG4837	Protein of unknown function (DUF1462)
HZ310_RS03720	COG1252	NADH dehydrogenase
HZ310_RS03725	COG4844	belongs to the
HZ310_RS03730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZ310_RS03735	COG0316	Belongs to the HesB IscA family
HZ310_RS03760	COG0492	ferredoxin-NADP+ reductase activity
HZ310_RS03765	COG1252	NADH dehydrogenase
HZ310_RS03780	COG3584	3D domain protein
HZ310_RS03785	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HZ310_RS03790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZ310_RS03795	COG2056	Na+-H+ antiporter family
HZ310_RS03800	COG4326	sporulation control protein
HZ310_RS03805	COG1268	BioY protein
HZ310_RS03810	COG0686	Belongs to the AlaDH PNT family
HZ310_RS03815	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HZ310_RS03815	COG2508	Transcriptional regulator
HZ310_RS03820	COG4842	Belongs to the WXG100 family
HZ310_RS03825	COG5417	Belongs to the EsaB family
HZ310_RS03830	COG4499	WXG100 protein secretion system (Wss), protein YukC
HZ310_RS03835	COG1674	ftsk spoiiie
HZ310_RS03835	COG0433	COG0433 Predicted ATPase
HZ310_RS03840	COG1511	domain protein
HZ310_RS03850	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS03855	COG1418	mRNA catabolic process
HZ310_RS03870	COG0628	permease
HZ310_RS03890	COG5506	Protein of unknown function (DUF1694)
HZ310_RS03895	COG1335	isochorismatase
HZ310_RS03900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZ310_RS03905	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HZ310_RS03920	COG0142	geranyltranstransferase activity
HZ310_RS03930	COG4585	Histidine kinase
HZ310_RS03935	COG2197	response regulator
HZ310_RS03940	COG2050	protein possibly involved in aromatic compounds catabolism
HZ310_RS03945	COG1320	monovalent cation:proton antiporter activity
HZ310_RS03950	COG2212	antiporter activity
HZ310_RS03955	COG1863	multisubunit Na H antiporter MnhE subunit
HZ310_RS03960	COG0651	ATP synthesis coupled electron transport
HZ310_RS03965	COG1006	Multisubunit Na H antiporter MnhC subunit
HZ310_RS03970	COG2111	Na H antiporter
HZ310_RS03975	COG2111	Na H antiporter
HZ310_RS03975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZ310_RS03985	COG3493	citrate carrier protein
HZ310_RS04010	COG4565	transcriptional regulatory protein
HZ310_RS04015	COG3290	protein histidine kinase activity
HZ310_RS04030	COG3011	Protein conserved in bacteria
HZ310_RS04035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ310_RS04040	COG2814	Major facilitator Superfamily
HZ310_RS04045	COG5018	Exonuclease
HZ310_RS04060	COG2205	protein histidine kinase activity
HZ310_RS04065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZ310_RS04075	COG2267	carboxylic ester hydrolase activity
HZ310_RS04080	COG1522	sequence-specific DNA binding
HZ310_RS04085	COG0436	Aminotransferase
HZ310_RS04090	COG1098	S1 RNA binding domain
HZ310_RS04095	COG2155	Conserved Protein
HZ310_RS04100	COG1979	alcohol dehydrogenase
HZ310_RS04105	COG1979	alcohol dehydrogenase
HZ310_RS04110	COG0166	Belongs to the GPI family
HZ310_RS04130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZ310_RS04140	COG2738	Putative neutral zinc metallopeptidase
HZ310_RS04145	COG1253	flavin adenine dinucleotide binding
HZ310_RS04150	COG0432	Pfam Uncharacterised protein family UPF0047
HZ310_RS04155	COG2070	2-Nitropropane dioxygenase
HZ310_RS04170	COG0840	transmembrane signaling receptor activity
HZ310_RS04175	COG0840	transmembrane signaling receptor activity
HZ310_RS04180	COG0840	transmembrane signaling receptor activity
HZ310_RS04185	COG0840	transmembrane signaling receptor activity
HZ310_RS04190	COG0693	protein deglycase activity
HZ310_RS04195	COG0673	inositol 2-dehydrogenase activity
HZ310_RS04205	COG0628	permease
HZ310_RS04210	COG1968	undecaprenyl-diphosphatase activity
HZ310_RS04220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZ310_RS04235	COG1396	sequence-specific DNA binding
HZ310_RS04255	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HZ310_RS04265	COG1595	DNA-templated transcription, initiation
HZ310_RS04270	COG5484	DNA packaging
HZ310_RS04275	COG1783	phage Terminase large subunit
HZ310_RS04280	COG5518	Phage portal protein
HZ310_RS04285	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HZ310_RS04290	COG4653	Phage capsid family
HZ310_RS04345	COG3953	SLT domain
HZ310_RS04345	COG5280	Phage tail tape measure protein TP901
HZ310_RS04345	COG5280	Phage tail tape measure protein TP901
HZ310_RS04345	COG3953	SLT domain
HZ310_RS04350	COG1652	LysM domain
HZ310_RS04355	COG4193	domain, Protein
HZ310_RS04365	COG3628	GPW Gp25 family protein
HZ310_RS04370	COG3299	homolog of phage Mu protein gp47
HZ310_RS04375	COG3778	Protein conserved in bacteria
HZ310_RS04415	COG5632	N-Acetylmuramoyl-L-alanine amidase
HZ310_RS04415	COG3409	Peptidoglycan-binding domain 1 protein
HZ310_RS04535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ310_RS04535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ310_RS04590	COG1780	Probably involved in ribonucleotide reductase function
HZ310_RS04595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ310_RS04605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ310_RS04630	COG0756	dUTP diphosphatase activity
HZ310_RS04650	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HZ310_RS04740	COG0582	viral genome integration into host DNA
HZ310_RS04825	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ310_RS04890	COG4974	Belongs to the 'phage' integrase family
HZ310_RS04900	COG1510	regulation of RNA biosynthetic process
HZ310_RS04905	COG1012	belongs to the aldehyde dehydrogenase family
HZ310_RS04910	COG1454	alcohol dehydrogenase
HZ310_RS04915	COG2318	DinB family
HZ310_RS04920	COG1585	Membrane protein implicated in regulation of membrane protease activity
HZ310_RS04925	COG2268	Band 7 protein
HZ310_RS04930	COG0772	Belongs to the SEDS family
HZ310_RS04935	COG0772	Belongs to the SEDS family
HZ310_RS04940	COG3339	Conserved Protein
HZ310_RS04945	COG1247	-acetyltransferase
HZ310_RS04950	COG3859	Proton-coupled thiamine transporter YuaJ
HZ310_RS05075	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HZ310_RS05080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZ310_RS05085	COG1575	Belongs to the MenA family. Type 1 subfamily
HZ310_RS05090	COG1169	isochorismate synthase
HZ310_RS05095	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HZ310_RS05100	COG0596	Alpha beta hydrolase
HZ310_RS05105	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HZ310_RS05110	COG0318	PFAM AMP-dependent synthetase and ligase
HZ310_RS05115	COG4948	Mandelate Racemase Muconate Lactonizing
HZ310_RS05130	COG1294	oxidase, subunit
HZ310_RS05135	COG1271	oxidase subunit
HZ310_RS05150	COG3443	Belongs to the bacterial solute-binding protein 9 family
HZ310_RS05150	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZ310_RS05155	COG0288	reversible hydration of carbon dioxide
HZ310_RS05160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZ310_RS05165	COG1854	S-ribosylhomocysteine lyase activity
HZ310_RS05180	COG0783	Belongs to the Dps family
HZ310_RS05190	COG4824	toxin secretion phage lysis holin
HZ310_RS05205	COG2310	stress, protein
HZ310_RS05210	COG0494	nUDIX hydrolase
HZ310_RS05215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZ310_RS05220	COG1116	anion transmembrane transporter activity
HZ310_RS05225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZ310_RS05245	COG1233	COG1233 Phytoene dehydrogenase and related
HZ310_RS05250	COG1506	peptidase
HZ310_RS05260	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HZ310_RS05265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZ310_RS05270	COG0367	asparagine synthase
HZ310_RS05275	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZ310_RS05280	COG2267	carboxylic ester hydrolase activity
HZ310_RS05290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HZ310_RS05295	COG1242	4 iron, 4 sulfur cluster binding
HZ310_RS05310	COG1725	Transcriptional regulator
HZ310_RS05315	COG1131	(ABC) transporter
HZ310_RS05325	COG1136	(ABC) transporter
HZ310_RS05330	COG0577	efflux transmembrane transporter activity
HZ310_RS05335	COG2433	Pfam Transposase IS66
HZ310_RS05340	COG2202	Pas domain
HZ310_RS05340	COG1366	Belongs to the anti-sigma-factor antagonist family
HZ310_RS05350	COG0495	leucyl-tRNA aminoacylation
HZ310_RS05355	COG1073	alpha beta
HZ310_RS05360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ310_RS05365	COG0395	ABC-type sugar transport system, permease component
HZ310_RS05370	COG1653	transport
HZ310_RS05375	COG0656	L-ascorbic acid biosynthetic process
HZ310_RS05380	COG2814	Major facilitator Superfamily
HZ310_RS05385	COG1733	regulation of RNA biosynthetic process
HZ310_RS05390	COG2207	Transcriptional regulator
HZ310_RS05395	COG4209	transmembrane transport
HZ310_RS05400	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HZ310_RS05405	COG1653	transport
HZ310_RS05410	COG0673	inositol 2-dehydrogenase activity
HZ310_RS05415	COG5578	integral membrane protein
HZ310_RS05420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ310_RS05430	COG3196	Protein conserved in bacteria
HZ310_RS05435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZ310_RS05445	COG2081	HI0933 family
HZ310_RS05450	COG2244	polysaccharide biosynthetic process
HZ310_RS05455	COG1187	pseudouridine synthase activity
HZ310_RS05460	COG1349	DNA-binding transcription factor activity
HZ310_RS05465	COG2252	PERMEase
HZ310_RS05470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZ310_RS05475	COG3340	Belongs to the peptidase S51 family
HZ310_RS05480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZ310_RS05485	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HZ310_RS05495	COG1597	lipid kinase activity
HZ310_RS05500	COG0510	thiamine kinase activity
HZ310_RS05510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZ310_RS05515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ310_RS05520	COG0281	malic enzyme
HZ310_RS05525	COG5584	Small secreted protein
HZ310_RS05530	COG1363	Peptidase, m42
HZ310_RS05545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS05550	COG4848	Belongs to the UPF0354 family
HZ310_RS05555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ310_RS05560	COG1674	ftsk spoiiie
HZ310_RS05565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZ310_RS05570	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HZ310_RS05575	COG4980	gas vesicle protein
HZ310_RS05580	COG3118	belongs to the thioredoxin family
HZ310_RS05585	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZ310_RS05585	COG1605	Chorismate mutase
HZ310_RS05590	COG1609	Transcriptional regulator
HZ310_RS05595	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZ310_RS05600	COG0517	IMP dehydrogenase activity
HZ310_RS05605	COG0454	-acetyltransferase
HZ310_RS05610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZ310_RS05615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZ310_RS05620	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HZ310_RS05630	COG1335	isochorismatase
HZ310_RS05640	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZ310_RS05645	COG1956	GAF domain-containing protein
HZ310_RS05650	COG1309	transcriptional regulator
HZ310_RS05655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZ310_RS05660	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HZ310_RS05665	COG1114	Component of the transport system for branched-chain amino acids
HZ310_RS05670	COG1114	Component of the transport system for branched-chain amino acids
HZ310_RS05675	COG1104	cysteine desulfurase activity
HZ310_RS05680	COG0301	tRNA thio-modification
HZ310_RS05690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZ310_RS05695	COG1279	arginine transmembrane transporter activity
HZ310_RS05705	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZ310_RS05710	COG0402	S-adenosylhomocysteine deaminase activity
HZ310_RS05715	COG0577	efflux transmembrane transporter activity
HZ310_RS05720	COG1136	(ABC) transporter
HZ310_RS05725	COG1695	Transcriptional regulator
HZ310_RS05730	COG0772	Belongs to the SEDS family
HZ310_RS05735	COG2205	protein histidine kinase activity
HZ310_RS05740	COG0745	RESPONSE REGULATOR receiver
HZ310_RS05745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ310_RS05750	COG2197	response regulator
HZ310_RS05755	COG4585	Histidine kinase
HZ310_RS05760	COG3239	Fatty acid desaturase
HZ310_RS05770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZ310_RS05775	COG0616	signal peptide processing
HZ310_RS05780	COG1714	RDD family
HZ310_RS05790	COG3874	Sporulation protein YtfJ
HZ310_RS05795	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HZ310_RS05800	COG0827	DNA restriction-modification system
HZ310_RS05805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HZ310_RS05810	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZ310_RS05815	COG0137	argininosuccinate synthase activity
HZ310_RS05820	COG0165	Argininosuccinate lyase
HZ310_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS05835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZ310_RS05840	COG4109	DRTGG domain
HZ310_RS05850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HZ310_RS05870	COG0587	DNA-directed DNA polymerase activity
HZ310_RS05875	COG0281	malic enzyme
HZ310_RS05880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZ310_RS05885	COG0825	malonyl-CoA metabolic process
HZ310_RS05890	COG0205	6-phosphofructokinase activity
HZ310_RS05900	COG3030	protein affecting phage T7 exclusion by the F plasmid
HZ310_RS05905	COG0628	permease
HZ310_RS05910	COG2707	UPF0756 membrane protein
HZ310_RS05915	COG0372	Belongs to the citrate synthase family
HZ310_RS05920	COG0538	isocitrate dehydrogenase activity
HZ310_RS05925	COG0039	L-malate dehydrogenase activity
HZ310_RS05930	COG0745	RESPONSE REGULATOR receiver
HZ310_RS05935	COG5002	protein histidine kinase activity
HZ310_RS05940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ310_RS05940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ310_RS05945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZ310_RS05950	COG1971	Probably functions as a manganese efflux pump
HZ310_RS05955	COG0237	dephospho-CoA kinase activity
HZ310_RS05960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZ310_RS05965	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HZ310_RS05975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZ310_RS05980	COG3611	Membrane attachment protein
HZ310_RS05985	COG1484	DNA-dependent DNA replication
HZ310_RS05990	COG0398	Pfam SNARE associated Golgi protein
HZ310_RS06000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZ310_RS06010	COG1011	Hydrolase
HZ310_RS06015	COG3275	phosphorelay sensor kinase activity
HZ310_RS06020	COG3279	Response regulator of the LytR AlgR family
HZ310_RS06030	COG1346	cytolysis
HZ310_RS06035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZ310_RS06040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HZ310_RS06045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZ310_RS06050	COG3326	Membrane
HZ310_RS06060	COG1363	Peptidase, m42
HZ310_RS06065	COG1966	Carbon starvation protein
HZ310_RS06075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZ310_RS06080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZ310_RS06085	COG0072	phenylalanine-tRNA ligase activity
HZ310_RS06085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ310_RS06090	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZ310_RS06095	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HZ310_RS06100	COG1286	toxin biosynthetic process
HZ310_RS06105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZ310_RS06105	COG1796	DNA polymerase
HZ310_RS06110	COG1193	negative regulation of DNA recombination
HZ310_RS06115	COG3766	membrane
HZ310_RS06125	COG0318	PFAM AMP-dependent synthetase and ligase
HZ310_RS06130	COG1309	transcriptional regulator
HZ310_RS06135	COG1024	Enoyl-CoA hydratase
HZ310_RS06140	COG2086	electron transfer activity
HZ310_RS06145	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZ310_RS06150	COG3534	alpha-L-arabinofuranosidase
HZ310_RS06155	COG3118	belongs to the thioredoxin family
HZ310_RS06160	COG0322	excinuclease ABC activity
HZ310_RS06165	COG0527	aspartate kinase activity
HZ310_RS06170	COG1719	4-vinyl reductase, 4VR
HZ310_RS06175	COG2009	succinate dehydrogenase
HZ310_RS06180	COG1053	succinate dehydrogenase
HZ310_RS06185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZ310_RS06190	COG0824	Thioesterase
HZ310_RS06200	COG2828	Protein conserved in bacteria
HZ310_RS06205	COG0583	DNA-binding transcription factor activity
HZ310_RS06210	COG2851	Citrate transporter
HZ310_RS06215	COG2197	response regulator
HZ310_RS06220	COG1846	Transcriptional regulator
HZ310_RS06225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZ310_RS06230	COG5401	PFAM Sporulation and spore germination
HZ310_RS06235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZ310_RS06240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZ310_RS06245	COG0622	Phosphoesterase
HZ310_RS06270	COG1696	Membrane protein involved in D-alanine export
HZ310_RS06275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZ310_RS06280	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HZ310_RS06285	COG3339	Conserved Protein
HZ310_RS06290	COG2706	6-phosphogluconolactonase activity
HZ310_RS06295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZ310_RS06300	COG0028	Belongs to the TPP enzyme family
HZ310_RS06305	COG0440	acetolactate synthase activity
HZ310_RS06310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZ310_RS06315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZ310_RS06320	COG0473	3-isopropylmalate dehydrogenase activity
HZ310_RS06325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZ310_RS06330	COG0066	3-isopropylmalate dehydratase activity
HZ310_RS06335	COG1477	protein flavinylation
HZ310_RS06335	COG0457	Tetratricopeptide repeat
HZ310_RS06340	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZ310_RS06345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZ310_RS06350	COG0470	DNA polymerase III
HZ310_RS06350	COG1067	ATP-dependent peptidase activity
HZ310_RS06355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZ310_RS06360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZ310_RS06370	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZ310_RS06375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZ310_RS06380	COG0181	hydroxymethylbilane synthase activity
HZ310_RS06385	COG1587	Uroporphyrinogen-III synthase
HZ310_RS06390	COG0113	porphobilinogen synthase activity
HZ310_RS06395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZ310_RS06400	COG1388	LysM domain
HZ310_RS06405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZ310_RS06415	COG0525	valine-tRNA ligase activity
HZ310_RS06420	COG0285	dihydrofolate synthase activity
HZ310_RS06425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HZ310_RS06435	COG0424	maF-like protein
HZ310_RS06445	COG1077	Cell shape determining protein MreB Mrl
HZ310_RS06455	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HZ310_RS06460	COG0850	regulation of cytokinetic process
HZ310_RS06465	COG2894	cell division
HZ310_RS06470	COG0739	heme binding
HZ310_RS06475	COG1994	Peptidase M50
HZ310_RS06480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZ310_RS06485	COG2868	ribosomal protein
HZ310_RS06490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZ310_RS06495	COG3290	protein histidine kinase activity
HZ310_RS06500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZ310_RS06505	COG4492	Belongs to the UPF0735 family
HZ310_RS06510	COG0077	Prephenate dehydratase
HZ310_RS06515	COG1827	regulation of RNA biosynthetic process
HZ310_RS06520	COG1104	cysteine desulfurase activity
HZ310_RS06525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HZ310_RS06530	COG0157	Belongs to the NadC ModD family
HZ310_RS06535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HZ310_RS06540	COG1388	LysM domain
HZ310_RS06555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HZ310_RS06570	COG2112	serine threonine protein kinase
HZ310_RS06580	COG0632	four-way junction helicase activity
HZ310_RS06585	COG2255	four-way junction helicase activity
HZ310_RS06595	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZ310_RS06600	COG0343	queuine tRNA-ribosyltransferase activity
HZ310_RS06605	COG1862	Preprotein translocase
HZ310_RS06615	COG2323	membrane
HZ310_RS06620	COG2244	polysaccharide biosynthetic process
HZ310_RS06630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZ310_RS06630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZ310_RS06635	COG0490	domain, Protein
HZ310_RS06640	COG5416	Lipopolysaccharide assembly protein A domain
HZ310_RS06645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HZ310_RS06645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZ310_RS06650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ310_RS06655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZ310_RS06660	COG1490	D-aminoacyl-tRNA deacylase activity
HZ310_RS06665	COG4991	sh3 domain protein
HZ310_RS06665	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ310_RS06665	COG3103	Sh3 type 3 domain protein
HZ310_RS06675	COG0124	histidyl-tRNA synthetase
HZ310_RS06690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZ310_RS06695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZ310_RS06700	COG1959	2 iron, 2 sulfur cluster binding
HZ310_RS06705	COG1104	cysteine desulfurase activity
HZ310_RS06710	COG0482	sulfurtransferase activity
HZ310_RS06715	COG0457	Tetratricopeptide repeat
HZ310_RS06720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZ310_RS06725	COG3881	PFAM PRC-barrel domain
HZ310_RS06740	COG0765	amino acid transport
HZ310_RS06745	COG0765	amino acid transport
HZ310_RS06750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ310_RS06755	COG1126	abc transporter atp-binding protein
HZ310_RS06760	COG0628	permease
HZ310_RS06765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZ310_RS06770	COG4472	Bacterial protein of unknown function (DUF965)
HZ310_RS06775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZ310_RS06780	COG3906	Belongs to the UPF0473 family
HZ310_RS06785	COG1268	BioY protein
HZ310_RS06790	COG0318	PFAM AMP-dependent synthetase and ligase
HZ310_RS06795	COG0183	Belongs to the thiolase family
HZ310_RS06800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZ310_RS06805	COG4122	O-methyltransferase activity
HZ310_RS06820	COG0572	uridine kinase
HZ310_RS06830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZ310_RS06835	COG0768	penicillin binding
HZ310_RS06850	COG2226	methyltransferase
HZ310_RS06855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HZ310_RS06860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZ310_RS06865	COG0626	cystathionine gamma-synthase activity
HZ310_RS06890	COG2226	methyltransferase
HZ310_RS06895	COG1063	alcohol dehydrogenase
HZ310_RS06900	COG0583	DNA-binding transcription factor activity
HZ310_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS06925	COG1063	alcohol dehydrogenase
HZ310_RS06930	COG3546	catalase activity
HZ310_RS06940	COG0765	amino acid transport
HZ310_RS06945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ310_RS06950	COG1126	abc transporter atp-binding protein
HZ310_RS06955	COG1960	acyl-CoA dehydrogenase activity
HZ310_RS06960	COG2602	Beta-lactamase
HZ310_RS07000	COG1733	regulation of RNA biosynthetic process
HZ310_RS07005	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HZ310_RS07010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HZ310_RS07020	COG1609	Transcriptional regulator
HZ310_RS07035	COG2160	L-arabinose isomerase activity
HZ310_RS07065	COG0726	polysaccharide deacetylase
HZ310_RS07110	COG0457	Tetratricopeptide repeat
HZ310_RS07120	COG2755	lipolytic protein G-D-S-L family
HZ310_RS07135	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HZ310_RS07140	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HZ310_RS07145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZ310_RS07150	COG1534	Rna-binding protein
HZ310_RS07155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZ310_RS07160	COG1713	HD superfamily hydrolase involved in NAD metabolism
HZ310_RS07165	COG0799	negative regulation of ribosome biogenesis
HZ310_RS07170	COG2226	methyltransferase
HZ310_RS07175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZ310_RS07180	COG1555	photosystem II stabilization
HZ310_RS07185	COG2131	deaminase
HZ310_RS07190	COG2333	competence protein COMEC
HZ310_RS07190	COG0658	competence protein
HZ310_RS07200	COG1466	dna polymerase III delta subunit
HZ310_RS07205	COG0268	Binds directly to 16S ribosomal RNA
HZ310_RS07210	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZ310_RS07215	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ310_RS07225	COG0481	GTPase activity
HZ310_RS07230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZ310_RS07235	COG1420	regulation of RNA biosynthetic process
HZ310_RS07240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZ310_RS07245	COG0443	Heat shock 70 kDa protein
HZ310_RS07250	COG0484	heat shock protein binding
HZ310_RS07255	COG2264	protein methyltransferase activity
HZ310_RS07260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZ310_RS07265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ310_RS07270	COG1283	sodium-dependent phosphate transmembrane transporter activity
HZ310_RS07280	COG1610	YqeY-like protein
HZ310_RS07285	COG1030	water channel activity
HZ310_RS07290	COG4864	UPF0365 protein
HZ310_RS07310	COG0561	phosphatase activity
HZ310_RS07315	COG1702	phosphate starvation-inducible protein PhoH
HZ310_RS07320	COG1480	7TM receptor with intracellular HD hydrolase
HZ310_RS07325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZ310_RS07330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZ310_RS07335	COG0295	cytidine deaminase activity
HZ310_RS07340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZ310_RS07350	COG1381	Involved in DNA repair and RecF pathway recombination
HZ310_RS07355	COG0752	glycyl-tRNA synthetase alpha subunit
HZ310_RS07360	COG0751	glycine-tRNA ligase activity
HZ310_RS07365	COG0517	IMP dehydrogenase activity
HZ310_RS07370	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZ310_RS07375	COG1671	Belongs to the UPF0178 family
HZ310_RS07380	COG0358	DNA primase activity
HZ310_RS07385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZ310_RS07390	COG2010	Cytochrome c
HZ310_RS07395	COG2384	SAM-dependent methyltransferase
HZ310_RS07400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZ310_RS07405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZ310_RS07415	COG0513	Belongs to the DEAD box helicase family
HZ310_RS07420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HZ310_RS07430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ310_RS07435	COG1121	(ABC) transporter
HZ310_RS07440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ310_RS07445	COG0735	belongs to the Fur family
HZ310_RS07450	COG1940	carbohydrate kinase activity
HZ310_RS07455	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HZ310_RS07460	COG4709	membrane
HZ310_RS07465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZ310_RS07470	COG1388	LysM domain
HZ310_RS07475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZ310_RS07480	COG5521	maltodextrose utilization protein MalA
HZ310_RS07485	COG2839	Protein conserved in bacteria
HZ310_RS07490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZ310_RS07495	COG0477	Major facilitator Superfamily
HZ310_RS07505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZ310_RS07510	COG0573	inorganic phosphate transmembrane transporter activity
HZ310_RS07515	COG0581	inorganic phosphate transmembrane transporter activity
HZ310_RS07520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZ310_RS07525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZ310_RS07530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZ310_RS07540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZ310_RS07545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZ310_RS07560	COG0705	Rhomboid family
HZ310_RS07560	COG0457	Tetratricopeptide repeat
HZ310_RS07565	COG4483	Protein conserved in bacteria
HZ310_RS07570	COG1940	carbohydrate kinase activity
HZ310_RS07575	COG1368	sulfuric ester hydrolase activity
HZ310_RS07580	COG2866	Carboxypeptidase
HZ310_RS07585	COG2814	Major facilitator Superfamily
HZ310_RS07590	COG0011	TIGRFAM Protein of
HZ310_RS07600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ310_RS07615	COG1393	Belongs to the ArsC family
HZ310_RS07625	COG1366	Belongs to the anti-sigma-factor antagonist family
HZ310_RS07630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZ310_RS07635	COG1459	type II secretion system
HZ310_RS07640	COG4537	Required for transformation and DNA binding
HZ310_RS07645	COG4970	Tfp pilus assembly protein FimT
HZ310_RS07675	COG0681	Belongs to the peptidase S26 family
HZ310_RS07700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ310_RS07705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZ310_RS07710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZ310_RS07715	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZ310_RS07720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ310_RS07725	COG0095	Lipoate-protein ligase
HZ310_RS07730	COG1321	iron dependent repressor
HZ310_RS07735	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZ310_RS07745	COG3872	metal-dependent enzyme
HZ310_RS07755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZ310_RS07760	COG0006	proline dipeptidase activity
HZ310_RS07765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZ310_RS07775	COG3854	ATPases associated with a variety of cellular activities
HZ310_RS07815	COG0511	ligase activity, forming carbon-carbon bonds
HZ310_RS07820	COG0439	Biotin carboxylase
HZ310_RS07825	COG1302	Protein conserved in bacteria
HZ310_RS07830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZ310_RS07835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZ310_RS07840	COG1570	exodeoxyribonuclease VII activity
HZ310_RS07845	COG1722	exodeoxyribonuclease VII activity
HZ310_RS07850	COG0142	geranyltranstransferase activity
HZ310_RS07855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZ310_RS07860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HZ310_RS07865	COG1438	arginine binding
HZ310_RS07870	COG0497	DNA recombination
HZ310_RS07875	COG0750	zinc metalloprotease
HZ310_RS07880	COG0745	RESPONSE REGULATOR receiver
HZ310_RS07885	COG0457	Tetratricopeptide repeat
HZ310_RS07890	COG0584	glycerophosphoryl diester phosphodiesterase
HZ310_RS07900	COG3829	transcription factor binding
HZ310_RS07900	COG3290	protein histidine kinase activity
HZ310_RS07905	COG0280	phosphate acetyltransferase
HZ310_RS07910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZ310_RS07915	COG3426	butyrate kinase activity
HZ310_RS07920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ310_RS07925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZ310_RS07935	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ310_RS07945	COG1597	lipid kinase activity
HZ310_RS07955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ310_RS07960	COG0765	amino acid transport
HZ310_RS07965	COG1126	abc transporter atp-binding protein
HZ310_RS07970	COG4129	membrane
HZ310_RS07975	COG1376	ErfK ybiS ycfS ynhG family protein
HZ310_RS07985	COG0346	lactoylglutathione lyase activity
HZ310_RS07995	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZ310_RS08005	COG0706	membrane insertase activity
HZ310_RS08020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZ310_RS08025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HZ310_RS08030	COG4975	Glucose uptake
HZ310_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS08040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ310_RS08045	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZ310_RS08050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ310_RS08055	COG2723	6-phospho-beta-galactosidase activity
HZ310_RS08060	COG2188	Transcriptional regulator
HZ310_RS08065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZ310_RS08070	COG1234	tRNA 3'-trailer cleavage
HZ310_RS08075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ310_RS08080	COG0596	Alpha beta hydrolase
HZ310_RS08085	COG1902	pentaerythritol trinitrate reductase activity
HZ310_RS08090	COG4187	Peptidase family M20/M25/M40
HZ310_RS08100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZ310_RS08105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ310_RS08110	COG0300	oxidoreductase activity
HZ310_RS08120	COG1072	(Pantothenic acid kinase))
HZ310_RS08125	COG2211	Major facilitator Superfamily
HZ310_RS08135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZ310_RS08145	COG0456	acetyltransferase
HZ310_RS08150	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HZ310_RS08150	COG0456	acetyltransferase
HZ310_RS08155	COG4305	rare lipoprotein A
HZ310_RS08160	COG4918	Iron-sulphur cluster biosynthesis
HZ310_RS08170	COG0457	Tetratricopeptide repeat
HZ310_RS08175	COG1073	alpha beta
HZ310_RS08185	COG0667	Aldo Keto reductase
HZ310_RS08190	COG0494	nUDIX hydrolase
HZ310_RS08195	COG1379	DNA repair
HZ310_RS08200	COG2153	protein acetylation
HZ310_RS08210	COG1404	Belongs to the peptidase S8 family
HZ310_RS08215	COG1300	Membrane
HZ310_RS08220	COG0735	belongs to the Fur family
HZ310_RS08230	COG4974	Belongs to the 'phage' integrase family
HZ310_RS08235	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HZ310_RS08240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZ310_RS08245	COG1686	Belongs to the peptidase S11 family
HZ310_RS08255	COG2172	sigma factor antagonist activity
HZ310_RS08260	COG1191	sigma factor activity
HZ310_RS08280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZ310_RS08295	COG0697	spore germination
HZ310_RS08300	COG0019	diaminopimelate decarboxylase activity
HZ310_RS08305	COG4086	secreted protein
HZ310_RS08310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZ310_RS08315	COG2814	Major facilitator Superfamily
HZ310_RS08335	COG0307	riboflavin synthase, alpha
HZ310_RS08340	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ310_RS08340	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ310_RS08345	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZ310_RS08350	COG0456	acetyltransferase
HZ310_RS08355	COG1547	Domain of unknown function (DUF309)
HZ310_RS08365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZ310_RS08370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZ310_RS08380	COG1686	Belongs to the peptidase S11 family
HZ310_RS08385	COG2715	membrane protein required for spore maturation
HZ310_RS08390	COG0700	Nucleoside recognition
HZ310_RS08395	COG1187	pseudouridine synthase activity
HZ310_RS08400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS08405	COG1333	cytochrome c biogenesis protein
HZ310_RS08410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZ310_RS08415	COG0745	RESPONSE REGULATOR receiver
HZ310_RS08420	COG5002	protein histidine kinase activity
HZ310_RS08425	COG1595	DNA-templated transcription, initiation
HZ310_RS08435	COG3409	Peptidoglycan-binding domain 1 protein
HZ310_RS08435	COG5632	N-Acetylmuramoyl-L-alanine amidase
HZ310_RS08440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZ310_RS08445	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HZ310_RS08450	COG1141	Ferredoxin
HZ310_RS08455	COG4955	Helix-turn-helix domain
HZ310_RS08460	COG0514	ATP-dependent DNA helicase (RecQ)
HZ310_RS08465	COG1266	CAAX protease self-immunity
HZ310_RS08470	COG1388	LysM domain
HZ310_RS08480	COG1408	metallophosphoesterase
HZ310_RS08485	COG4862	establishment of competence for transformation
HZ310_RS08490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZ310_RS08495	COG0492	ferredoxin-NADP+ reductase activity
HZ310_RS08500	COG2339	peptidase activity
HZ310_RS08510	COG3409	Peptidoglycan-binding domain 1 protein
HZ310_RS08510	COG3773	Cell wall hydrolase
HZ310_RS08515	COG2959	enzyme of heme biosynthesis
HZ310_RS08520	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HZ310_RS08530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZ310_RS08535	COG0539	negative regulation of cytoplasmic translation
HZ310_RS08540	COG1304	FMN binding
HZ310_RS08565	COG1160	GTP binding
HZ310_RS08570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZ310_RS08585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HZ310_RS08590	COG0776	regulation of translation
HZ310_RS08595	COG0302	gtp cyclohydrolase
HZ310_RS08605	COG0142	geranyltranstransferase activity
HZ310_RS08610	COG2226	methyltransferase
HZ310_RS08615	COG0142	geranyltranstransferase activity
HZ310_RS08620	COG0105	UTP biosynthetic process
HZ310_RS08625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZ310_RS08630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZ310_RS08635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZ310_RS08640	COG4401	Chorismate mutase type I
HZ310_RS08650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZ310_RS08655	COG0134	indole-3-glycerol-phosphate synthase activity
HZ310_RS08660	COG0135	phosphoribosylanthranilate isomerase activity
HZ310_RS08665	COG0133	tryptophan synthase activity
HZ310_RS08670	COG0159	tryptophan synthase activity
HZ310_RS08675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZ310_RS08680	COG0287	Prephenate dehydrogenase
HZ310_RS08685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZ310_RS08690	COG0457	Tetratricopeptide repeat
HZ310_RS08695	COG5582	Belongs to the UPF0302 family
HZ310_RS08705	COG0723	plastoquinol--plastocyanin reductase activity
HZ310_RS08710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZ310_RS08715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZ310_RS08715	COG2010	Cytochrome c
HZ310_RS08720	COG4347	Protein of unknown function (DUF1405)
HZ310_RS08730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ310_RS08735	COG1694	Mazg nucleotide pyrophosphohydrolase
HZ310_RS08740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZ310_RS08745	COG1803	Methylglyoxal synthase
HZ310_RS08750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZ310_RS08755	COG0438	transferase activity, transferring glycosyl groups
HZ310_RS08760	COG0617	tRNA 3'-terminal CCA addition
HZ310_RS08770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZ310_RS08775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZ310_RS08780	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZ310_RS08785	COG1199	ATP-dependent helicase activity
HZ310_RS08785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZ310_RS08795	COG5353	protein conserved in bacteria
HZ310_RS08800	COG0017	Asparaginyl-tRNA synthetase
HZ310_RS08805	COG3935	DnaD domain protein
HZ310_RS08810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZ310_RS08820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ310_RS08820	COG4499	WXG100 protein secretion system (Wss), protein YukC
HZ310_RS08825	COG3331	DNA recombination
HZ310_RS08855	COG0071	Belongs to the small heat shock protein (HSP20) family
HZ310_RS08860	COG2190	(PTS) system
HZ310_RS08865	COG1902	pentaerythritol trinitrate reductase activity
HZ310_RS08870	COG1205	dead DEAH box helicase
HZ310_RS08870	COG1111	helicase
HZ310_RS08875	COG3359	exonuclease
HZ310_RS08885	COG4474	Belongs to the UPF0398 family
HZ310_RS08890	COG3599	regulation of cell shape
HZ310_RS08900	COG0116	Belongs to the methyltransferase superfamily
HZ310_RS08910	COG1199	ATP-dependent helicase activity
HZ310_RS08915	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HZ310_RS08920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ310_RS08925	COG2233	PERMEase
HZ310_RS08930	COG0726	polysaccharide deacetylase
HZ310_RS08935	COG3424	synthase
HZ310_RS08940	COG1755	Isoprenylcysteine carboxyl methyltransferase
HZ310_RS08950	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HZ310_RS08960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ310_RS08970	COG0328	RNA-DNA hybrid ribonuclease activity
HZ310_RS08975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZ310_RS08980	COG0328	RNA-DNA hybrid ribonuclease activity
HZ310_RS08995	COG1278	Cold shock
HZ310_RS09005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZ310_RS09010	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HZ310_RS09015	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HZ310_RS09020	COG0386	Belongs to the glutathione peroxidase family
HZ310_RS09025	COG1418	mRNA catabolic process
HZ310_RS09030	COG1413	lyase activity
HZ310_RS09035	COG0129	dihydroxy-acid dehydratase activity
HZ310_RS09045	COG2521	methyltransferase
HZ310_RS09045	COG2136	Putative SAM-dependent methyltransferase
HZ310_RS09055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HZ310_RS09060	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZ310_RS09065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZ310_RS09070	COG0204	Acyl-transferase
HZ310_RS09075	COG1272	protein, Hemolysin III
HZ310_RS09080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZ310_RS09085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZ310_RS09100	COG1999	signal sequence binding
HZ310_RS09105	COG2755	lipolytic protein G-D-S-L family
HZ310_RS09110	COG4698	Protein conserved in bacteria
HZ310_RS09130	COG1846	Transcriptional regulator
HZ310_RS09135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ310_RS09140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ310_RS09145	COG1086	Polysaccharide biosynthesis protein
HZ310_RS09155	COG4641	Protein conserved in bacteria
HZ310_RS09170	COG0463	Glycosyl transferase, family 2
HZ310_RS09175	COG3829	transcription factor binding
HZ310_RS09180	COG1509	lysine 2,3-aminomutase activity
HZ310_RS09190	COG4479	Belongs to the UPF0346 family
HZ310_RS09205	COG0671	phosphoesterase, PA-phosphatase related
HZ310_RS09215	COG0813	purine-nucleoside phosphorylase activity
HZ310_RS09220	COG1876	peptidase activity
HZ310_RS09230	COG2226	methyltransferase
HZ310_RS09235	COG0793	Belongs to the peptidase S41A family
HZ310_RS09235	COG3409	Peptidoglycan-binding domain 1 protein
HZ310_RS09240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZ310_RS09250	COG0778	Nitroreductase
HZ310_RS09255	COG1733	regulation of RNA biosynthetic process
HZ310_RS09270	COG2962	Rard protein
HZ310_RS09280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZ310_RS09285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZ310_RS09290	COG0534	Mate efflux family protein
HZ310_RS09295	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HZ310_RS09300	COG0791	NLP P60 protein
HZ310_RS09300	COG1388	LysM domain
HZ310_RS09305	COG2032	superoxide dismutase activity
HZ310_RS09310	COG0714	Associated with various cellular activities
HZ310_RS09315	COG4548	von Willebrand factor, type A
HZ310_RS09320	COG0567	Dehydrogenase, E1 component
HZ310_RS09325	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ310_RS09335	COG0385	Bile acid
HZ310_RS09340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZ310_RS09345	COG1657	PFAM Prenyltransferase squalene oxidase
HZ310_RS09350	COG1012	belongs to the aldehyde dehydrogenase family
HZ310_RS09375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZ310_RS09385	COG0514	ATP-dependent DNA helicase (RecQ)
HZ310_RS09390	COG3584	3D domain protein
HZ310_RS09390	COG1388	LysM domain
HZ310_RS09400	COG2322	membrane
HZ310_RS09405	COG0372	Belongs to the citrate synthase family
HZ310_RS09410	COG2079	MmgE PrpD family protein
HZ310_RS09415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HZ310_RS09420	COG0741	lytic transglycosylase activity
HZ310_RS09425	COG0531	amino acid
HZ310_RS09430	COG0640	Transcriptional regulator
HZ310_RS09440	COG2378	regulation of single-species biofilm formation
HZ310_RS09445	COG3708	Transcriptional regulator
HZ310_RS09455	COG1309	transcriptional regulator
HZ310_RS09475	COG1994	Peptidase M50
HZ310_RS09480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ310_RS09485	COG2211	Major facilitator Superfamily
HZ310_RS09495	COG1940	carbohydrate kinase activity
HZ310_RS09500	COG2115	Belongs to the xylose isomerase family
HZ310_RS09505	COG1070	Carbohydrate kinase
HZ310_RS09515	COG0243	molybdopterin cofactor binding
HZ310_RS09530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZ310_RS09535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZ310_RS09540	COG0454	-acetyltransferase
HZ310_RS09560	COG0583	DNA-binding transcription factor activity
HZ310_RS09565	COG0070	glutamate synthase
HZ310_RS09565	COG0069	glutamate synthase activity
HZ310_RS09565	COG0067	glutamate synthase
HZ310_RS09570	COG0493	'glutamate synthase
HZ310_RS09575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZ310_RS09580	COG2146	nitrite reductase [NAD(P)H] activity
HZ310_RS09585	COG2323	membrane
HZ310_RS09590	COG4677	pectinesterase activity
HZ310_RS09595	COG2027	D-alanyl-D-alanine carboxypeptidase
HZ310_RS09600	COG0534	Mate efflux family protein
HZ310_RS09620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ310_RS09630	COG1587	Uroporphyrinogen-III synthase
HZ310_RS09635	COG0586	Pfam SNARE associated Golgi protein
HZ310_RS09645	COG0166	Belongs to the GPI family
HZ310_RS09665	COG0247	lactate metabolic process
HZ310_RS09670	COG0277	FAD linked oxidase domain protein
HZ310_RS09675	COG3835	regulator
HZ310_RS09685	COG1942	4-Oxalocrotonate Tautomerase
HZ310_RS09690	COG1349	DNA-binding transcription factor activity
HZ310_RS09700	COG1649	PFAM Uncharacterised BCR, COG1649
HZ310_RS09705	COG1960	acyl-CoA dehydrogenase activity
HZ310_RS09710	COG0318	PFAM AMP-dependent synthetase and ligase
HZ310_RS09715	COG0439	Biotin carboxylase
HZ310_RS09720	COG0511	ligase activity, forming carbon-carbon bonds
HZ310_RS09725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZ310_RS09730	COG1024	Enoyl-CoA hydratase
HZ310_RS09735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZ310_RS09740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZ310_RS09745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZ310_RS09750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZ310_RS09755	COG1012	belongs to the aldehyde dehydrogenase family
HZ310_RS09775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ310_RS09785	COG1105	Belongs to the carbohydrate kinase PfkB family
HZ310_RS09790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ310_RS09790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ310_RS09790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS09795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ310_RS09795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS09795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ310_RS09805	COG2814	Major facilitator Superfamily
HZ310_RS09810	COG1846	Transcriptional regulator
HZ310_RS09815	COG5444	nuclease activity
HZ310_RS09830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS09845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZ310_RS09850	COG1609	Transcriptional regulator
HZ310_RS09855	COG1653	transport
HZ310_RS09860	COG1175	transmembrane transport
HZ310_RS09865	COG0395	ABC-type sugar transport system, permease component
HZ310_RS09870	COG1486	melibiose metabolic process
HZ310_RS09875	COG1012	belongs to the aldehyde dehydrogenase family
HZ310_RS09880	COG3507	Belongs to the glycosyl hydrolase 43 family
HZ310_RS09890	COG0745	RESPONSE REGULATOR receiver
HZ310_RS09895	COG2205	protein histidine kinase activity
HZ310_RS09910	COG2190	(PTS) system
HZ310_RS09910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS09910	COG1263	PTS System
HZ310_RS09915	COG2723	6-phospho-beta-galactosidase activity
HZ310_RS09925	COG0657	acetylesterase activity
HZ310_RS09995	COG0251	oxidation-reduction process
HZ310_RS10000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZ310_RS10010	COG1733	regulation of RNA biosynthetic process
HZ310_RS10015	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZ310_RS10020	COG0640	Transcriptional regulator
HZ310_RS10025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZ310_RS10030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ310_RS10035	COG0110	maltose O-acetyltransferase activity
HZ310_RS10040	COG0738	Major facilitator superfamily
HZ310_RS10050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZ310_RS10055	COG0187	DNA topoisomerase II activity
HZ310_RS10060	COG1832	CoA-binding protein
HZ310_RS10065	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HZ310_RS10070	COG4841	protein insertion into membrane
HZ310_RS10080	COG0824	Thioesterase
HZ310_RS10100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS10105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZ310_RS10120	COG0071	Belongs to the small heat shock protein (HSP20) family
HZ310_RS10130	COG4846	Membrane protein involved in cytochrome C biogenesis
HZ310_RS10135	COG0785	Cytochrome C biogenesis protein
HZ310_RS10145	COG3763	UPF0154 protein
HZ310_RS10155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZ310_RS10160	COG4224	UPF0291 protein
HZ310_RS10165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ310_RS10170	COG1388	LysM domain
HZ310_RS10175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZ310_RS10190	COG1366	Belongs to the anti-sigma-factor antagonist family
HZ310_RS10195	COG3209	COG3209 Rhs family protein
HZ310_RS10200	COG3591	Belongs to the peptidase S1B family
HZ310_RS10205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HZ310_RS10205	COG2124	cytochrome p450
HZ310_RS10210	COG1309	transcriptional regulator
HZ310_RS10215	COG2323	membrane
HZ310_RS10235	COG1556	Lactate utilization protein
HZ310_RS10240	COG1139	Iron-sulfur cluster binding protein
HZ310_RS10245	COG0247	lactate metabolic process
HZ310_RS10250	COG0702	epimerase
HZ310_RS10255	COG1959	2 iron, 2 sulfur cluster binding
HZ310_RS10265	COG4876	unkown
HZ310_RS10270	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HZ310_RS10275	COG3285	dna ligase
HZ310_RS10275	COG1793	dna ligase
HZ310_RS10280	COG3619	membrane
HZ310_RS10290	COG0457	Tetratricopeptide repeat
HZ310_RS10300	COG5646	InterPro IPR014922
HZ310_RS10350	COG5444	nuclease activity
HZ310_RS10365	COG3409	Peptidoglycan-binding domain 1 protein
HZ310_RS10365	COG5632	N-Acetylmuramoyl-L-alanine amidase
HZ310_RS10370	COG4824	toxin secretion phage lysis holin
HZ310_RS10395	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ310_RS10470	COG1802	Transcriptional regulator
HZ310_RS10470	COG4626	Terminase
HZ310_RS10615	COG4974	Belongs to the 'phage' integrase family
HZ310_RS10620	COG0174	glutamine synthetase
HZ310_RS10625	COG0789	Transcriptional regulator
HZ310_RS10630	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HZ310_RS10635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZ310_RS10640	COG0464	growth
HZ310_RS10650	COG4112	unkown
HZ310_RS10655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ310_RS10660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ310_RS10665	COG1780	Probably involved in ribonucleotide reductase function
HZ310_RS10680	COG1923	regulation of RNA biosynthetic process
HZ310_RS10685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZ310_RS10710	COG2076	Multidrug Resistance protein
HZ310_RS10715	COG1764	response to oxidative stress
HZ310_RS10720	COG4195	phage-related replication protein
HZ310_RS10725	COG1404	Belongs to the peptidase S8 family
HZ310_RS10730	COG0457	Tetratricopeptide repeat
HZ310_RS10735	COG4195	phage-related replication protein
HZ310_RS10740	COG1329	Transcriptional regulator
HZ310_RS10755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZ310_RS10760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZ310_RS10770	COG4550	Control of competence regulator ComK, YlbF/YmcA
HZ310_RS10775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ310_RS10785	COG0156	8-amino-7-oxononanoate synthase activity
HZ310_RS10790	COG1063	alcohol dehydrogenase
HZ310_RS10795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZ310_RS10800	COG2359	stage V sporulation protein S
HZ310_RS10805	COG1692	metallophosphoesterase
HZ310_RS10810	COG1418	mRNA catabolic process
HZ310_RS10815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HZ310_RS10820	COG1546	Belongs to the CinA family
HZ310_RS10820	COG1058	Belongs to the CinA family
HZ310_RS10825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZ310_RS10830	COG1426	Protein conserved in bacteria
HZ310_RS10845	COG0300	oxidoreductase activity
HZ310_RS10850	COG1033	growth of symbiont in host cell
HZ310_RS10850	COG2409	Drug exporters of the RND superfamily
HZ310_RS10860	COG0612	Peptidase, M16
HZ310_RS10865	COG0612	Peptidase, M16
HZ310_RS10870	COG1033	growth of symbiont in host cell
HZ310_RS10870	COG2409	Drug exporters of the RND superfamily
HZ310_RS10875	COG2814	Major facilitator Superfamily
HZ310_RS10880	COG2188	Transcriptional regulator
HZ310_RS10885	COG4980	gas vesicle protein
HZ310_RS10885	COG1674	ftsk spoiiie
HZ310_RS10895	COG0740	serine-type endopeptidase activity
HZ310_RS10900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZ310_RS10910	COG0527	aspartate kinase activity
HZ310_RS10915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZ310_RS10920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZ310_RS10925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ310_RS10930	COG1873	PFAM PRC-barrel domain
HZ310_RS10940	COG0612	Peptidase, M16
HZ310_RS10945	COG0726	polysaccharide deacetylase
HZ310_RS10950	COG1185	polyribonucleotide nucleotidyltransferase activity
HZ310_RS10955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZ310_RS10960	COG0196	riboflavin kinase activity
HZ310_RS10965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZ310_RS10970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZ310_RS10975	COG1550	Protein conserved in bacteria
HZ310_RS10980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZ310_RS10985	COG1358	cellular component organization or biogenesis
HZ310_RS10990	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HZ310_RS10995	COG0195	Participates in both transcription termination and antitermination
HZ310_RS11000	COG0779	Required for maturation of 30S ribosomal subunits
HZ310_RS11010	COG3693	PFAM glycoside hydrolase, family 10
HZ310_RS11025	COG2176	DNA-directed DNA polymerase activity
HZ310_RS11030	COG0442	prolyl-tRNA aminoacylation
HZ310_RS11035	COG0750	zinc metalloprotease
HZ310_RS11040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZ310_RS11045	COG4589	Belongs to the CDS family
HZ310_RS11050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZ310_RS11055	COG0233	cytoplasmic translational termination
HZ310_RS11065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZ310_RS11070	COG0052	Belongs to the universal ribosomal protein uS2 family
HZ310_RS11080	COG1191	sigma factor activity
HZ310_RS11090	COG1776	CheC inhibitor of MCP methylation
HZ310_RS11095	COG0835	chemotaxis
HZ310_RS11100	COG2198	Histidine kinase
HZ310_RS11100	COG0643	Histidine kinase
HZ310_RS11105	COG2201	protein-glutamate methylesterase activity
HZ310_RS11110	COG0455	bacterial-type flagellum organization
HZ310_RS11115	COG1419	protein localization to endoplasmic reticulum
HZ310_RS11120	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZ310_RS11125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZ310_RS11130	COG1684	flagellar biosynthetic protein fliR
HZ310_RS11135	COG1987	bacterial-type flagellum assembly
HZ310_RS11140	COG1338	Plays a role in the flagellum-specific transport system
HZ310_RS11145	COG3190	flagellar
HZ310_RS11150	COG2201	protein-glutamate methylesterase activity
HZ310_RS11155	COG1776	CheC inhibitor of MCP methylation
HZ310_RS11155	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZ310_RS11160	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZ310_RS11165	COG1580	Controls the rotational direction of flagella during chemotaxis
HZ310_RS11170	COG1582	Flagellar protein (FlbD)
HZ310_RS11175	COG4786	Flagellar basal body rod
HZ310_RS11180	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZ310_RS11185	COG3144	bacterial-type flagellum assembly
HZ310_RS11195	COG2882	bacterial-type flagellum organization
HZ310_RS11200	COG1157	protein secretion by the type III secretion system
HZ310_RS11205	COG1317	bacterial-type flagellum organization
HZ310_RS11210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZ310_RS11215	COG1766	The M ring may be actively involved in energy transduction
HZ310_RS11220	COG1677	Flagellar hook-basal body complex protein FliE
HZ310_RS11225	COG1558	bacterial-type flagellum-dependent cell motility
HZ310_RS11230	COG1815	bacterial-type flagellum-dependent cell motility
HZ310_RS11235	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HZ310_RS11240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HZ310_RS11245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HZ310_RS11250	COG4974	Belongs to the 'phage' integrase family
HZ310_RS11255	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HZ310_RS11260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZ310_RS11265	COG0758	DNA mediated transformation
HZ310_RS11270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZ310_RS11275	COG0045	succinate-CoA ligase (ADP-forming) activity
HZ310_RS11280	COG2257	FlhB HrpN YscU SpaS Family
HZ310_RS11290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZ310_RS11295	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HZ310_RS11300	COG0335	large ribosomal subunit rRNA binding
HZ310_RS11305	COG0336	Belongs to the RNA methyltransferase TrmD family
HZ310_RS11310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZ310_RS11320	COG1837	Belongs to the UPF0109 family
HZ310_RS11325	COG0228	four-way junction DNA binding
HZ310_RS11330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZ310_RS11335	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HZ310_RS11340	COG0552	protein localization to endoplasmic reticulum
HZ310_RS11345	COG1196	nuclear chromosome segregation
HZ310_RS11355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZ310_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS11365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZ310_RS11370	COG0416	fatty acid biosynthetic process
HZ310_RS11375	COG1349	DNA-binding transcription factor activity
HZ310_RS11380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZ310_RS11385	COG1760	l-serine dehydratase
HZ310_RS11390	COG1760	l-serine dehydratase
HZ310_RS11395	COG1461	Dihydroxyacetone kinase
HZ310_RS11400	COG1302	Protein conserved in bacteria
HZ310_RS11405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZ310_RS11415	COG1564	THIamine pyrophosphokinase
HZ310_RS11420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZ310_RS11425	COG1162	GTPase activity
HZ310_RS11430	COG0515	serine threonine protein kinase
HZ310_RS11430	COG2815	serine threonine protein kinase
HZ310_RS11435	COG0631	protein serine/threonine phosphatase activity
HZ310_RS11440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZ310_RS11445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZ310_RS11445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZ310_RS11450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZ310_RS11455	COG0242	peptide deformylase activity
HZ310_RS11460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZ310_RS11465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZ310_RS11470	COG1758	RNA polymerase activity
HZ310_RS11475	COG0194	GDP metabolic process
HZ310_RS11480	COG2052	Domain of unknown function (DUF370)
HZ310_RS11485	COG1561	YicC-like family, N-terminal region
HZ310_RS11490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZ310_RS11500	COG1648	precorrin-2 dehydrogenase activity
HZ310_RS11505	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HZ310_RS11510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZ310_RS11515	COG0529	Catalyzes the synthesis of activated sulfate
HZ310_RS11520	COG2046	Belongs to the sulfate adenylyltransferase family
HZ310_RS11525	COG0306	phosphate transporter
HZ310_RS11530	COG0175	sulfate reduction
HZ310_RS11540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZ310_RS11545	COG0284	orotidine-5'-phosphate decarboxylase activity
HZ310_RS11550	COG0167	dihydroorotate dehydrogenase activity
HZ310_RS11555	COG0543	2 iron, 2 sulfur cluster binding
HZ310_RS11560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZ310_RS11565	COG0505	Belongs to the CarA family
HZ310_RS11570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZ310_RS11575	COG0540	Belongs to the ATCase OTCase family
HZ310_RS11580	COG2233	PERMEase
HZ310_RS11585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZ310_RS11590	COG0564	pseudouridine synthase activity
HZ310_RS11595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZ310_RS11600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZ310_RS11605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZ310_RS11610	COG3599	regulation of cell shape
HZ310_RS11615	COG2302	S4 RNA-binding domain
HZ310_RS11620	COG0762	integral membrane protein
HZ310_RS11625	COG1799	cell septum assembly
HZ310_RS11630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZ310_RS11640	COG1873	PFAM PRC-barrel domain
HZ310_RS11645	COG1119	ATPase activity
HZ310_RS11655	COG3732	PTS system glucitol sorbitol-specific
HZ310_RS11660	COG3730	PTS system glucitol sorbitol-specific
HZ310_RS11675	COG2390	Transcriptional regulator
HZ310_RS11680	COG1191	sigma factor activity
HZ310_RS11685	COG1191	sigma factor activity
HZ310_RS11695	COG1404	Belongs to the peptidase S8 family
HZ310_RS11695	COG4412	M6 family metalloprotease domain protein
HZ310_RS11700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZ310_RS11705	COG0849	cell division
HZ310_RS11710	COG3856	small basic protein
HZ310_RS11715	COG3879	Bacterial protein of unknown function (DUF881)
HZ310_RS11720	COG3879	Bacterial protein of unknown function (DUF881)
HZ310_RS11725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HZ310_RS11730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZ310_RS11735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZ310_RS11740	COG0772	Belongs to the SEDS family
HZ310_RS11745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HZ310_RS11750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZ310_RS11755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZ310_RS11760	COG0768	penicillin binding
HZ310_RS11770	COG4839	cell division protein FtsL
HZ310_RS11775	COG0275	rRNA processing
HZ310_RS11780	COG2001	Belongs to the MraZ family
HZ310_RS11785	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HZ310_RS11790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZ310_RS11795	COG0454	-acetyltransferase
HZ310_RS11805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZ310_RS11810	COG1399	metal-binding, possibly nucleic acid-binding protein
HZ310_RS11820	COG3480	Lon protease (S16) C-terminal proteolytic domain
HZ310_RS11825	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZ310_RS11830	COG3314	Sporulation integral membrane protein YlbJ
HZ310_RS11835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZ310_RS11840	COG0742	ribosomal rna small subunit methyltransferase
HZ310_RS11845	COG4471	UPF0298 protein
HZ310_RS11850	COG3679	Belongs to the UPF0342 family
HZ310_RS11870	COG2340	Cysteine-rich secretory protein family
HZ310_RS11875	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HZ310_RS11885	COG3336	cytochrome c oxidase
HZ310_RS11890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HZ310_RS11895	COG1845	cytochrome c oxidase, subunit III
HZ310_RS11900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZ310_RS11905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZ310_RS11905	COG2010	Cytochrome c
HZ310_RS11910	COG0109	protoheme IX farnesyltransferase activity
HZ310_RS11915	COG1612	heme a metabolic process
HZ310_RS11925	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HZ310_RS11930	COG0772	Belongs to the SEDS family
HZ310_RS11935	COG4838	Belongs to the UPF0358 family
HZ310_RS11940	COG2066	Belongs to the glutaminase family
HZ310_RS11945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HZ310_RS11950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HZ310_RS11960	COG4896	Protein conserved in bacteria
HZ310_RS11985	COG0483	inositol monophosphate 1-phosphatase activity
HZ310_RS11995	COG4493	Belongs to the UPF0637 family
HZ310_RS12000	COG4476	Belongs to the UPF0223 family
HZ310_RS12005	COG1982	Orn Lys Arg decarboxylase major
HZ310_RS12015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS12020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ310_RS12025	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ310_RS12030	COG0022	dehydrogenase e1 component
HZ310_RS12035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZ310_RS12050	COG0242	peptide deformylase activity
HZ310_RS12055	COG0561	phosphatase activity
HZ310_RS12065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZ310_RS12070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HZ310_RS12075	COG0569	domain protein
HZ310_RS12080	COG2105	PFAM AIG2 family protein
HZ310_RS12080	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HZ310_RS12085	COG3852	Histidine kinase
HZ310_RS12090	COG2002	toxin-antitoxin pair type II binding
HZ310_RS12095	COG1077	Cell shape determining protein MreB Mrl
HZ310_RS12105	COG2309	aminopeptidase activity
HZ310_RS12115	COG0488	(ABC) transporter
HZ310_RS12125	COG0681	Belongs to the peptidase S26 family
HZ310_RS12130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS12130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ310_RS12130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ310_RS12135	COG1105	Belongs to the carbohydrate kinase PfkB family
HZ310_RS12140	COG1349	DNA-binding transcription factor activity
HZ310_RS12145	COG0577	efflux transmembrane transporter activity
HZ310_RS12150	COG1136	(ABC) transporter
HZ310_RS12155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ310_RS12170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HZ310_RS12175	COG0314	molybdopterin synthase activity
HZ310_RS12180	COG1763	Mo-molybdopterin cofactor biosynthetic process
HZ310_RS12185	COG0303	'Molybdopterin
HZ310_RS12190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZ310_RS12195	COG0746	molybdenum cofactor guanylyltransferase activity
HZ310_RS12210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS12215	COG0450	alkyl hydroperoxide reductase
HZ310_RS12220	COG0668	transmembrane transport
HZ310_RS12230	COG1473	amidohydrolase
HZ310_RS12235	COG2171	N-acyltransferase activity
HZ310_RS12240	COG0716	FMN binding
HZ310_RS12250	COG0716	FMN binding
HZ310_RS12260	COG0583	DNA-binding transcription factor activity
HZ310_RS12265	COG0517	IMP dehydrogenase activity
HZ310_RS12275	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HZ310_RS12280	COG4703	Protein of unknown function (DUF1797)
HZ310_RS12285	COG3546	catalase activity
HZ310_RS12290	COG2200	EAL domain
HZ310_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS12300	COG1408	metallophosphoesterase
HZ310_RS12305	COG1376	ErfK ybiS ycfS ynhG family protein
HZ310_RS12310	COG2814	Major facilitator Superfamily
HZ310_RS12335	COG0835	chemotaxis
HZ310_RS12335	COG0784	Response regulator, receiver
HZ310_RS12345	COG1714	RDD family
HZ310_RS12355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZ310_RS12360	COG0436	Aminotransferase
HZ310_RS12365	COG4191	Histidine kinase
HZ310_RS12370	COG0768	penicillin binding
HZ310_RS12375	COG2340	Cysteine-rich secretory protein family
HZ310_RS12380	COG2084	Dehydrogenase
HZ310_RS12390	COG0840	transmembrane signaling receptor activity
HZ310_RS12395	COG1533	DNA photolyase activity
HZ310_RS12405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZ310_RS12410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS12415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS12415	COG2190	(PTS) system
HZ310_RS12415	COG1263	PTS System
HZ310_RS12420	COG3711	transcriptional antiterminator
HZ310_RS12425	COG1609	Transcriptional regulator
HZ310_RS12435	COG0006	proline dipeptidase activity
HZ310_RS12440	COG2217	Heavy metal translocating P-type atpase
HZ310_RS12445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS12450	COG2244	polysaccharide biosynthetic process
HZ310_RS12455	COG3773	Cell wall hydrolase
HZ310_RS12465	COG4873	Protein conserved in bacteria
HZ310_RS12475	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZ310_RS12480	COG0602	queuosine metabolic process
HZ310_RS12485	COG0720	synthase
HZ310_RS12490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HZ310_RS12495	COG3949	Membrane
HZ310_RS12500	COG0542	response to heat
HZ310_RS12505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZ310_RS12510	COG1360	Flagellar Motor Protein
HZ310_RS12515	COG1846	Transcriptional regulator
HZ310_RS12520	COG3852	Histidine kinase
HZ310_RS12530	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HZ310_RS12535	COG0235	Class ii aldolase
HZ310_RS12540	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HZ310_RS12545	COG1850	ribulose-bisphosphate carboxylase activity
HZ310_RS12550	COG0436	Aminotransferase
HZ310_RS12555	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HZ310_RS12560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HZ310_RS12565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZ310_RS12570	COG5002	protein histidine kinase activity
HZ310_RS12575	COG3594	Acyltransferase
HZ310_RS12590	COG2323	membrane
HZ310_RS12595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZ310_RS12600	COG0501	Belongs to the peptidase M48B family
HZ310_RS12620	COG1191	sigma factor activity
HZ310_RS12625	COG0861	Integral membrane protein TerC family
HZ310_RS12630	COG0586	Pfam SNARE associated Golgi protein
HZ310_RS12635	COG3300	MHYT domain
HZ310_RS12635	COG5001	Diguanylate cyclase
HZ310_RS12640	COG1846	Transcriptional regulator
HZ310_RS12655	COG0789	Transcriptional regulator
HZ310_RS12670	COG0583	DNA-binding transcription factor activity
HZ310_RS12680	COG2239	Acts as a magnesium transporter
HZ310_RS12690	COG3212	peptidase
HZ310_RS12695	COG3212	peptidase
HZ310_RS12700	COG5002	protein histidine kinase activity
HZ310_RS12700	COG3850	Histidine kinase
HZ310_RS12705	COG0745	RESPONSE REGULATOR receiver
HZ310_RS12710	COG1404	Belongs to the peptidase S8 family
HZ310_RS12715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HZ310_RS12720	COG0590	tRNA wobble adenosine to inosine editing
HZ310_RS12725	COG1764	response to oxidative stress
HZ310_RS12730	COG1846	Transcriptional regulator
HZ310_RS12735	COG1764	response to oxidative stress
HZ310_RS12745	COG0457	Tetratricopeptide repeat
HZ310_RS12750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZ310_RS12755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZ310_RS12760	COG0788	formyltetrahydrofolate deformylase activity
HZ310_RS12770	COG2076	Multidrug Resistance protein
HZ310_RS12775	COG2076	Multidrug Resistance protein
HZ310_RS12790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZ310_RS12810	COG1607	acyl-coa hydrolase
HZ310_RS12815	COG1834	amidinotransferase
HZ310_RS12820	COG4608	Belongs to the ABC transporter superfamily
HZ310_RS12825	COG0791	NLP P60 protein
HZ310_RS12830	COG4948	Mandelate Racemase Muconate Lactonizing
HZ310_RS12835	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZ310_RS12840	COG4166	transmembrane transport
HZ310_RS12845	COG0444	Belongs to the ABC transporter superfamily
HZ310_RS12850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ310_RS12855	COG0601	transmembrane transport
HZ310_RS12860	COG2362	D-Aminopeptidase
HZ310_RS12865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZ310_RS12870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ310_RS12875	COG0346	lactoylglutathione lyase activity
HZ310_RS12880	COG0531	amino acid
HZ310_RS12890	COG2390	Transcriptional regulator
HZ310_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS12900	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS12905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ310_RS12910	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ310_RS12915	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ310_RS12915	COG0022	dehydrogenase e1 component
HZ310_RS12920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZ310_RS12940	COG3775	system Galactitol-specific IIC component
HZ310_RS12950	COG0405	Gamma-glutamyltransferase
HZ310_RS12960	COG1392	Phosphate transport regulator
HZ310_RS12965	COG0306	phosphate transporter
HZ310_RS12980	COG5632	N-Acetylmuramoyl-L-alanine amidase
HZ310_RS12980	COG3409	Peptidoglycan-binding domain 1 protein
HZ310_RS12985	COG2856	Zn peptidase
HZ310_RS12990	COG4195	phage-related replication protein
HZ310_RS13020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZ310_RS13025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZ310_RS13030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZ310_RS13035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZ310_RS13045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZ310_RS13065	COG0457	Tetratricopeptide repeat
HZ310_RS13090	COG2807	transmembrane transport
HZ310_RS13095	COG0583	DNA-binding transcription factor activity
HZ310_RS13110	COG0583	DNA-binding transcription factor activity
HZ310_RS13115	COG3173	Aminoglycoside phosphotransferase
HZ310_RS13190	COG3409	Peptidoglycan-binding domain 1 protein
HZ310_RS13190	COG5632	N-Acetylmuramoyl-L-alanine amidase
HZ310_RS13225	COG3778	Protein conserved in bacteria
HZ310_RS13230	COG3299	homolog of phage Mu protein gp47
HZ310_RS13235	COG3628	GPW Gp25 family protein
HZ310_RS13245	COG4193	domain, Protein
HZ310_RS13250	COG1652	LysM domain
HZ310_RS13255	COG3953	SLT domain
HZ310_RS13255	COG5280	Phage tail tape measure protein TP901
HZ310_RS13255	COG5280	Phage tail tape measure protein TP901
HZ310_RS13255	COG3953	SLT domain
HZ310_RS13315	COG4653	Phage capsid family
HZ310_RS13320	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HZ310_RS13330	COG2369	cell adhesion
HZ310_RS13335	COG5518	Phage portal protein
HZ310_RS13340	COG1783	phage Terminase large subunit
HZ310_RS13395	COG4282	regulation of fungal-type cell wall biogenesis
HZ310_RS13430	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HZ310_RS13440	COG0305	Participates in initiation and elongation during chromosome replication
HZ310_RS13500	COG1396	sequence-specific DNA binding
HZ310_RS13510	COG2856	Zn peptidase
HZ310_RS13515	COG0582	viral genome integration into host DNA
HZ310_RS13525	COG0626	cystathionine gamma-synthase activity
HZ310_RS13530	COG0626	cystathionine gamma-synthase activity
HZ310_RS13535	COG2382	esterase
HZ310_RS13540	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HZ310_RS13545	COG2153	protein acetylation
HZ310_RS13555	COG0210	DNA helicase
HZ310_RS13615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZ310_RS13620	COG0351	phosphomethylpyrimidine kinase
HZ310_RS13625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZ310_RS13630	COG2022	thiamine diphosphate biosynthetic process
HZ310_RS13635	COG2104	thiamine diphosphate biosynthetic process
HZ310_RS13645	COG0352	thiamine-phosphate diphosphorylase activity
HZ310_RS13650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HZ310_RS13655	COG0569	domain protein
HZ310_RS13655	COG0475	glutathione-regulated potassium exporter activity
HZ310_RS13660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZ310_RS13665	COG0564	pseudouridine synthase activity
HZ310_RS13670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZ310_RS13675	COG2357	RelA SpoT domain protein
HZ310_RS13685	COG4116	CYTH
HZ310_RS13690	COG0741	lytic transglycosylase activity
HZ310_RS13695	COG2346	COG2346, Truncated hemoglobins
HZ310_RS13705	COG1164	Oligoendopeptidase f
HZ310_RS13715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ310_RS13720	COG4862	establishment of competence for transformation
HZ310_RS13725	COG0861	Integral membrane protein TerC family
HZ310_RS13730	COG1393	Belongs to the ArsC family
HZ310_RS13735	COG0456	acetyltransferase
HZ310_RS13745	COG4608	Belongs to the ABC transporter superfamily
HZ310_RS13750	COG0444	Belongs to the ABC transporter superfamily
HZ310_RS13755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ310_RS13760	COG0601	transmembrane transport
HZ310_RS13765	COG4166	transmembrane transport
HZ310_RS13770	COG0180	Tryptophanyl-tRNA synthetase
HZ310_RS13790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ310_RS13795	COG0601	transmembrane transport
HZ310_RS13805	COG4608	Belongs to the ABC transporter superfamily
HZ310_RS13810	COG0444	Belongs to the ABC transporter superfamily
HZ310_RS13815	COG5504	Zn-dependent protease
HZ310_RS13820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZ310_RS13825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZ310_RS13840	COG1744	ABC transporter substrate-binding protein PnrA-like
HZ310_RS13850	COG2267	carboxylic ester hydrolase activity
HZ310_RS13860	COG2814	Major facilitator Superfamily
HZ310_RS13870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZ310_RS13875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZ310_RS13880	COG0505	Belongs to the CarA family
HZ310_RS13885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZ310_RS13890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZ310_RS13895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZ310_RS13900	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZ310_RS13915	COG2151	metal-sulfur cluster biosynthetic enzyme
HZ310_RS13920	COG1073	alpha beta
HZ310_RS13925	COG0561	phosphatase activity
HZ310_RS13945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ310_RS13950	COG1307	EDD domain protein, DegV family
HZ310_RS13955	COG0840	transmembrane signaling receptor activity
HZ310_RS13965	COG2996	Protein conserved in bacteria
HZ310_RS13970	COG1666	GTP binding
HZ310_RS13975	COG0646	methionine synthase
HZ310_RS13975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZ310_RS13980	COG1410	methionine synthase
HZ310_RS13980	COG0646	methionine synthase
HZ310_RS14010	COG0076	glutamate decarboxylase activity
HZ310_RS14040	COG1917	Cupin 2, conserved barrel domain protein
HZ310_RS14040	COG2207	Transcriptional regulator
HZ310_RS14045	COG0534	Mate efflux family protein
HZ310_RS14050	COG1562	ergosterol biosynthetic process
HZ310_RS14065	COG0367	asparagine synthase
HZ310_RS14080	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZ310_RS14085	COG5337	Spore coat protein CotH
HZ310_RS14125	COG1403	HNH endonuclease
HZ310_RS14130	COG0419	ATPase involved in DNA repair
HZ310_RS14135	COG0420	3'-5' exonuclease activity
HZ310_RS14140	COG1074	ATP-dependent DNA helicase activity
HZ310_RS14145	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HZ310_RS14150	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HZ310_RS14155	COG2259	Doxx family
HZ310_RS14160	COG0501	Belongs to the peptidase M48B family
HZ310_RS14170	COG3180	Ammonia monooxygenase
HZ310_RS14175	COG0681	Belongs to the peptidase S26 family
HZ310_RS14180	COG0398	Pfam SNARE associated Golgi protein
HZ310_RS14190	COG1316	TRANSCRIPTIONal
HZ310_RS14195	COG2732	(Barnase) inhibitor
HZ310_RS14220	COG4903	ComK protein
HZ310_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS14235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ310_RS14235	COG0723	plastoquinol--plastocyanin reductase activity
HZ310_RS14240	COG0840	transmembrane signaling receptor activity
HZ310_RS14245	COG0406	alpha-ribazole phosphatase activity
HZ310_RS14250	COG1404	Belongs to the peptidase S8 family
HZ310_RS14255	COG0501	Belongs to the peptidase M48B family
HZ310_RS14265	COG0318	PFAM AMP-dependent synthetase and ligase
HZ310_RS14270	COG0095	Lipoate-protein ligase
HZ310_RS14275	COG1234	tRNA 3'-trailer cleavage
HZ310_RS14285	COG1301	dicarboxylic acid transport
HZ310_RS14290	COG1363	Peptidase, m42
HZ310_RS14295	COG1511	domain protein
HZ310_RS14300	COG1309	transcriptional regulator
HZ310_RS14315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZ310_RS14320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ310_RS14325	COG2329	Antibiotic biosynthesis monooxygenase
HZ310_RS14335	COG1473	amidohydrolase
HZ310_RS14345	COG4473	ABC transporter
HZ310_RS14350	COG1131	(ABC) transporter
HZ310_RS14355	COG0537	adenosine 5'-monophosphoramidase activity
HZ310_RS14360	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZ310_RS14375	COG4980	gas vesicle protein
HZ310_RS14380	COG1846	Transcriptional regulator
HZ310_RS14405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ310_RS14415	COG3481	metal-dependent phosphohydrolase, HD sub domain
HZ310_RS14420	COG4717	serine-type aminopeptidase activity
HZ310_RS14425	COG0420	3'-5' exonuclease activity
HZ310_RS14435	COG1024	Enoyl-CoA hydratase
HZ310_RS14445	COG0490	domain, Protein
HZ310_RS14450	COG0475	glutathione-regulated potassium exporter activity
HZ310_RS14465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZ310_RS14470	COG0561	phosphatase activity
HZ310_RS14475	COG3679	Belongs to the UPF0342 family
HZ310_RS14480	COG4399	Belongs to the UPF0754 family
HZ310_RS14485	COG0189	ligase activity
HZ310_RS14490	COG0189	ligase activity
HZ310_RS14500	COG2508	Transcriptional regulator
HZ310_RS14505	COG3842	ATPase activity
HZ310_RS14515	COG0702	epimerase
HZ310_RS14520	COG1132	(ABC) transporter
HZ310_RS14525	COG1132	(ABC) transporter
HZ310_RS14530	COG0589	response to stress
HZ310_RS14535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZ310_RS14540	COG0726	polysaccharide deacetylase
HZ310_RS14545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZ310_RS14550	COG0668	transmembrane transport
HZ310_RS14560	COG0584	glycerophosphoryl diester phosphodiesterase
HZ310_RS14565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZ310_RS14580	COG1253	flavin adenine dinucleotide binding
HZ310_RS14585	COG0789	Transcriptional regulator
HZ310_RS14590	COG1253	flavin adenine dinucleotide binding
HZ310_RS14595	COG0204	Acyl-transferase
HZ310_RS14600	COG1595	DNA-templated transcription, initiation
HZ310_RS14615	COG0791	NLP P60 protein
HZ310_RS14615	COG1388	LysM domain
HZ310_RS14620	COG1785	Belongs to the alkaline phosphatase family
HZ310_RS14625	COG2719	SpoVR family
HZ310_RS14630	COG1017	nitric oxide dioxygenase activity
HZ310_RS14630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZ310_RS14635	COG1959	2 iron, 2 sulfur cluster binding
HZ310_RS14640	COG0753	catalase activity
HZ310_RS14660	COG2197	response regulator
HZ310_RS14665	COG2203	Gaf domain
HZ310_RS14665	COG4585	Histidine kinase
HZ310_RS14670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZ310_RS14675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZ310_RS14680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZ310_RS14685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZ310_RS14690	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HZ310_RS14695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZ310_RS14700	COG3835	regulator
HZ310_RS14715	COG3153	acetyltransferase
HZ310_RS14715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZ310_RS14720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ310_RS14730	COG0564	pseudouridine synthase activity
HZ310_RS14735	COG3764	Sortase (surface protein transpeptidase)
HZ310_RS14740	COG4085	toxin activity
HZ310_RS14740	COG1525	nuclease
HZ310_RS14740	COG0737	Belongs to the 5'-nucleotidase family
HZ310_RS14745	COG5002	protein histidine kinase activity
HZ310_RS14750	COG5577	PFAM Coat F domain
HZ310_RS14775	COG3706	GGDEF domain
HZ310_RS14780	COG1278	Cold shock
HZ310_RS14790	COG0655	NAD(P)H dehydrogenase (quinone) activity
HZ310_RS14795	COG2814	Major facilitator Superfamily
HZ310_RS14800	COG1566	PFAM secretion protein HlyD family protein
HZ310_RS14805	COG2718	Belongs to the UPF0229 family
HZ310_RS14810	COG2766	serine protein kinase
HZ310_RS14820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZ310_RS14830	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZ310_RS14835	COG3382	B3 4 domain protein
HZ310_RS14865	COG1131	(ABC) transporter
HZ310_RS14875	COG2873	o-acetylhomoserine
HZ310_RS14880	COG0681	Belongs to the peptidase S26 family
HZ310_RS14885	COG1368	sulfuric ester hydrolase activity
HZ310_RS15030	COG0735	belongs to the Fur family
HZ310_RS15035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZ310_RS15040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZ310_RS15045	COG4129	membrane
HZ310_RS15065	COG4608	Belongs to the ABC transporter superfamily
HZ310_RS15070	COG0444	Belongs to the ABC transporter superfamily
HZ310_RS15075	COG1132	(ABC) transporter
HZ310_RS15080	COG3557	Belongs to the UPF0374 family
HZ310_RS15100	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS15110	COG1194	a g-specific adenine glycosylase
HZ310_RS15115	COG1988	membrane-bound metal-dependent
HZ310_RS15125	COG1191	sigma factor activity
HZ310_RS15135	COG2140	Oxalate decarboxylase
HZ310_RS15150	COG4485	Bacterial membrane protein, YfhO
HZ310_RS15155	COG0463	Glycosyl transferase, family 2
HZ310_RS15180	COG2137	regulation of response to DNA damage stimulus
HZ310_RS15185	COG1090	epimerase
HZ310_RS15205	COG0778	Nitroreductase
HZ310_RS15225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZ310_RS15225	COG0392	lysyltransferase activity
HZ310_RS15230	COG1846	Transcriptional regulator
HZ310_RS15240	COG2318	DinB family
HZ310_RS15260	COG1595	DNA-templated transcription, initiation
HZ310_RS15265	COG1742	UPF0060 membrane protein
HZ310_RS15270	COG1132	(ABC) transporter
HZ310_RS15275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ310_RS15280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ310_RS15280	COG2207	Transcriptional regulator
HZ310_RS15285	COG0492	ferredoxin-NADP+ reductase activity
HZ310_RS15290	COG2755	lipolytic protein G-D-S-L family
HZ310_RS15295	COG4637	Psort location Cytoplasmic, score
HZ310_RS15305	COG1309	transcriptional regulator
HZ310_RS15310	COG2076	Multidrug Resistance protein
HZ310_RS15315	COG2076	Multidrug Resistance protein
HZ310_RS15355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZ310_RS15370	COG2814	Major facilitator Superfamily
HZ310_RS15375	COG0789	Transcriptional regulator
HZ310_RS15395	COG1309	transcriptional regulator
HZ310_RS15400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZ310_RS15405	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HZ310_RS15415	COG0598	Magnesium transport protein CorA
HZ310_RS15425	COG0726	polysaccharide deacetylase
HZ310_RS15435	COG0535	radical SAM domain protein
HZ310_RS15440	COG0668	transmembrane transport
HZ310_RS15450	COG0217	transcriptional regulatory protein
HZ310_RS15460	COG0387	Pfam Sodium calcium exchanger
HZ310_RS15470	COG0477	Major facilitator Superfamily
HZ310_RS15475	COG1295	ribonuclease BN
HZ310_RS15480	COG4980	gas vesicle protein
HZ310_RS15485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ310_RS15490	COG1115	amino acid carrier protein
HZ310_RS15495	COG4840	Belongs to the UPF0435 family
HZ310_RS15500	COG0693	protein deglycase activity
HZ310_RS15505	COG0737	Belongs to the 5'-nucleotidase family
HZ310_RS15515	COG2188	Transcriptional regulator
HZ310_RS15520	COG0366	Alpha amylase catalytic
HZ310_RS15525	COG1263	PTS System
HZ310_RS15525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS15540	COG0076	glutamate decarboxylase activity
HZ310_RS15545	COG1368	sulfuric ester hydrolase activity
HZ310_RS15560	COG3739	integral membrane protein
HZ310_RS15565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS15565	COG1263	PTS System
HZ310_RS15570	COG0024	Methionine aminopeptidase
HZ310_RS15585	COG2258	MOSC domain
HZ310_RS15590	COG1254	Belongs to the acylphosphatase family
HZ310_RS15595	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HZ310_RS15600	COG1695	Transcriptional regulator
HZ310_RS15605	COG3479	Phenolic acid decarboxylase
HZ310_RS15615	COG2851	Citrate transporter
HZ310_RS15620	COG3181	Tripartite tricarboxylate transporter family receptor
HZ310_RS15625	COG4565	transcriptional regulatory protein
HZ310_RS15630	COG3290	protein histidine kinase activity
HZ310_RS15640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ310_RS15640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ310_RS15650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HZ310_RS15655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ310_RS15655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ310_RS15675	COG2130	NADP-dependent
HZ310_RS15680	COG0513	Belongs to the DEAD box helicase family
HZ310_RS15685	COG0488	(ABC) transporter
HZ310_RS15695	COG0789	Transcriptional regulator
HZ310_RS15700	COG0488	(ABC) transporter
HZ310_RS15705	COG0457	Tetratricopeptide repeat
HZ310_RS15705	COG0463	Glycosyl transferase, family 2
HZ310_RS15710	COG0531	amino acid
HZ310_RS15725	COG0071	Belongs to the small heat shock protein (HSP20) family
HZ310_RS15740	COG0471	metal ion transport
HZ310_RS15750	COG2223	nitrite transmembrane transporter activity
HZ310_RS15755	COG1442	glycosyl transferase family 8
HZ310_RS15760	COG1216	Glycosyl transferase, family 2
HZ310_RS15765	COG1442	glycosyl transferase family 8
HZ310_RS15770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ310_RS15775	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HZ310_RS15805	COG2211	Major facilitator Superfamily
HZ310_RS15815	COG1486	melibiose metabolic process
HZ310_RS15830	COG0492	ferredoxin-NADP+ reductase activity
HZ310_RS15835	COG1959	2 iron, 2 sulfur cluster binding
HZ310_RS15845	COG1486	melibiose metabolic process
HZ310_RS15850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS15850	COG1263	PTS System
HZ310_RS15855	COG1737	Transcriptional regulator
HZ310_RS15865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZ310_RS15880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZ310_RS15885	COG1597	lipid kinase activity
HZ310_RS15890	COG1957	nucleoside hydrolase
HZ310_RS15895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZ310_RS15900	COG1309	transcriptional regulator
HZ310_RS15905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZ310_RS15910	COG0154	amidase activity
HZ310_RS15915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZ310_RS15920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZ310_RS15925	COG1285	pathogenesis
HZ310_RS15930	COG1785	Belongs to the alkaline phosphatase family
HZ310_RS15935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZ310_RS15945	COG3321	synthase
HZ310_RS15945	COG4221	oxidoreductase activity
HZ310_RS15945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZ310_RS15945	COG0300	oxidoreductase activity
HZ310_RS15955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZ310_RS15965	COG1960	acyl-CoA dehydrogenase activity
HZ310_RS15980	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZ310_RS15995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZ310_RS16010	COG4851	CamS sex pheromone cAM373 precursor
HZ310_RS16015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZ310_RS16020	COG0210	DNA helicase
HZ310_RS16025	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HZ310_RS16040	COG0069	glutamate synthase activity
HZ310_RS16050	COG4496	protein, YerC YecD
HZ310_RS16055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HZ310_RS16065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZ310_RS16070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HZ310_RS16075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZ310_RS16080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZ310_RS16095	COG0151	Belongs to the GarS family
HZ310_RS16100	COG0138	bifunctional purine biosynthesis protein purh
HZ310_RS16105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZ310_RS16110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZ310_RS16115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HZ310_RS16120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZ310_RS16125	COG0047	phosphoribosylformylglycinamidine synthase activity
HZ310_RS16130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZ310_RS16135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZ310_RS16140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZ310_RS16145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZ310_RS16150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZ310_RS16160	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HZ310_RS16165	COG3064	Membrane
HZ310_RS16170	COG2252	PERMEase
HZ310_RS16175	COG0583	DNA-binding transcription factor activity
HZ310_RS16180	COG2814	Major facilitator Superfamily
HZ310_RS16195	COG1595	DNA-templated transcription, initiation
HZ310_RS16225	COG1522	sequence-specific DNA binding
HZ310_RS16235	COG2207	Transcriptional regulator
HZ310_RS16245	COG0519	Catalyzes the synthesis of GMP from XMP
HZ310_RS16245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZ310_RS16250	COG1305	Transglutaminase-like
HZ310_RS16255	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HZ310_RS16260	COG0714	Associated with various cellular activities
HZ310_RS16265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HZ310_RS16270	COG1113	amino acid transport
HZ310_RS16275	COG2132	Multicopper oxidase
HZ310_RS16285	COG0823	Involved in the tonB-independent uptake of proteins
HZ310_RS16290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZ310_RS16315	COG0459	protein refolding
HZ310_RS16320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HZ310_RS16325	COG1266	CAAX protease self-immunity
HZ310_RS16340	COG0805	protein transport
HZ310_RS16345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZ310_RS16350	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HZ310_RS16355	COG0315	cyclic pyranopterin monophosphate synthase activity
HZ310_RS16360	COG0488	(ABC) transporter
HZ310_RS16365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZ310_RS16370	COG0456	acetyltransferase
HZ310_RS16375	COG1214	PFAM Peptidase M22, glycoprotease
HZ310_RS16380	COG0802	atpase or kinase
HZ310_RS16385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZ310_RS16425	COG1301	dicarboxylic acid transport
HZ310_RS16435	COG0697	spore germination
HZ310_RS16440	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HZ310_RS16450	COG4122	O-methyltransferase activity
HZ310_RS16460	COG0667	Aldo Keto reductase
HZ310_RS16465	COG0583	DNA-binding transcription factor activity
HZ310_RS16470	COG0456	acetyltransferase
HZ310_RS16480	COG1396	sequence-specific DNA binding
HZ310_RS16495	COG0778	Nitroreductase
HZ310_RS16500	COG1846	Transcriptional regulator
HZ310_RS16505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZ310_RS16510	COG1309	transcriptional regulator
HZ310_RS16545	COG2197	response regulator
HZ310_RS16550	COG4585	Histidine kinase
HZ310_RS16555	COG2409	Drug exporters of the RND superfamily
HZ310_RS16560	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HZ310_RS16565	COG2814	Major facilitator Superfamily
HZ310_RS16585	COG0252	asparaginase activity
HZ310_RS16610	COG0583	DNA-binding transcription factor activity
HZ310_RS16630	COG0477	Major facilitator Superfamily
HZ310_RS16645	COG0789	Transcriptional regulator
HZ310_RS16650	COG1064	alcohol dehydrogenase
HZ310_RS16655	COG1329	Transcriptional regulator
HZ310_RS16660	COG1278	Cold shock
HZ310_RS16665	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HZ310_RS16665	COG0456	acetyltransferase
HZ310_RS16680	COG0604	alcohol dehydrogenase
HZ310_RS16725	COG3284	Transcriptional regulator
HZ310_RS16730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ310_RS16735	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZ310_RS16740	COG0022	dehydrogenase e1 component
HZ310_RS16745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZ310_RS16750	COG3091	SprT-like family
HZ310_RS16760	COG2183	response to ionizing radiation
HZ310_RS16765	COG2208	phosphoserine phosphatase activity
HZ310_RS16770	COG1191	sigma factor activity
HZ310_RS16775	COG2172	sigma factor antagonist activity
HZ310_RS16780	COG1366	Belongs to the anti-sigma-factor antagonist family
HZ310_RS16785	COG2208	phosphoserine phosphatase activity
HZ310_RS16790	COG2172	sigma factor antagonist activity
HZ310_RS16795	COG1366	Belongs to the anti-sigma-factor antagonist family
HZ310_RS16800	COG1366	Belongs to the anti-sigma-factor antagonist family
HZ310_RS16805	COG2337	Toxic component of a toxin-antitoxin (TA) module
HZ310_RS16810	COG0864	Transcriptional regulator
HZ310_RS16815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZ310_RS16820	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HZ310_RS16825	COG0736	holo-[acyl-carrier-protein] synthase activity
HZ310_RS16830	COG0705	Rhomboid family
HZ310_RS16835	COG3428	Bacterial PH domain
HZ310_RS16840	COG3402	PFAM membrane-flanked domain
HZ310_RS16845	COG0513	Belongs to the DEAD box helicase family
HZ310_RS16860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZ310_RS16865	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZ310_RS16870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS16885	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HZ310_RS16890	COG1131	(ABC) transporter
HZ310_RS16900	COG1301	dicarboxylic acid transport
HZ310_RS16905	COG0628	permease
HZ310_RS16910	COG1301	dicarboxylic acid transport
HZ310_RS16915	COG4565	transcriptional regulatory protein
HZ310_RS16920	COG3290	protein histidine kinase activity
HZ310_RS16925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HZ310_RS16930	COG2217	Heavy metal translocating P-type atpase
HZ310_RS16935	COG2261	transglycosylase associated protein
HZ310_RS16940	COG1914	H( )-stimulated, divalent metal cation uptake system
HZ310_RS16945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZ310_RS16965	COG5444	nuclease activity
HZ310_RS16970	COG0028	Belongs to the TPP enzyme family
HZ310_RS16975	COG0531	amino acid
HZ310_RS16985	COG1215	transferase activity, transferring glycosyl groups
HZ310_RS16990	COG5298	Protein conserved in bacteria
HZ310_RS16995	COG3706	GGDEF domain
HZ310_RS17000	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HZ310_RS17005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZ310_RS17005	COG0551	DNA topoisomerase type I activity
HZ310_RS17015	COG0473	3-isopropylmalate dehydrogenase activity
HZ310_RS17020	COG0697	spore germination
HZ310_RS17025	COG2207	Transcriptional regulator
HZ310_RS17025	COG1917	Cupin 2, conserved barrel domain protein
HZ310_RS17030	COG1802	Transcriptional regulator
HZ310_RS17035	COG2814	Major facilitator Superfamily
HZ310_RS17055	COG3871	stress protein (general stress protein 26)
HZ310_RS17060	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS17065	COG2226	methyltransferase
HZ310_RS17070	COG3711	transcriptional antiterminator
HZ310_RS17080	COG2755	lipolytic protein G-D-S-L family
HZ310_RS17085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZ310_RS17090	COG1414	Transcriptional regulator
HZ310_RS17095	COG1984	allophanate hydrolase subunit 2
HZ310_RS17100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HZ310_RS17105	COG4336	lyase activity
HZ310_RS17110	COG1914	H( )-stimulated, divalent metal cation uptake system
HZ310_RS17115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HZ310_RS17120	COG0457	Tetratricopeptide repeat
HZ310_RS17145	COG0561	phosphatase activity
HZ310_RS17155	COG0346	lactoylglutathione lyase activity
HZ310_RS17175	COG0840	transmembrane signaling receptor activity
HZ310_RS17180	COG0246	Mannitol dehydrogenase
HZ310_RS17185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS17190	COG2213	PTS system mannitol-specific
HZ310_RS17195	COG1276	copper resistance
HZ310_RS17195	COG2372	response to copper ion
HZ310_RS17200	COG4549	nuclear export factor GLE1
HZ310_RS17205	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZ310_RS17210	COG1012	belongs to the aldehyde dehydrogenase family
HZ310_RS17215	COG0531	amino acid
HZ310_RS17220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZ310_RS17225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ310_RS17230	COG0640	Transcriptional regulator
HZ310_RS17240	COG1309	transcriptional regulator
HZ310_RS17245	COG2814	Major facilitator Superfamily
HZ310_RS17250	COG0527	aspartate kinase activity
HZ310_RS17255	COG1366	Belongs to the anti-sigma-factor antagonist family
HZ310_RS17260	COG3850	Histidine kinase
HZ310_RS17260	COG5002	protein histidine kinase activity
HZ310_RS17265	COG0745	RESPONSE REGULATOR receiver
HZ310_RS17270	COG2079	MmgE PrpD family protein
HZ310_RS17275	COG1473	amidohydrolase
HZ310_RS17280	COG1126	abc transporter atp-binding protein
HZ310_RS17285	COG0765	amino acid transport
HZ310_RS17290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ310_RS17295	COG0456	acetyltransferase
HZ310_RS17300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ310_RS17305	COG5434	Belongs to the glycosyl hydrolase 28 family
HZ310_RS17310	COG3104	oligopeptide transport
HZ310_RS17315	COG0833	amino acid
HZ310_RS17320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ310_RS17325	COG0765	amino acid transport
HZ310_RS17330	COG1126	abc transporter atp-binding protein
HZ310_RS17335	COG2364	Membrane
HZ310_RS17350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ310_RS17355	COG0697	spore germination
HZ310_RS17360	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HZ310_RS17375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZ310_RS17380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZ310_RS17385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZ310_RS17395	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZ310_RS17400	COG3842	ATPase activity
HZ310_RS17420	COG3209	COG3209 Rhs family protein
HZ310_RS17425	COG3290	protein histidine kinase activity
HZ310_RS17425	COG0840	transmembrane signaling receptor activity
HZ310_RS17435	COG2746	aminoglycoside 3-N-acetyltransferase activity
HZ310_RS17440	COG1522	sequence-specific DNA binding
HZ310_RS17445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZ310_RS17455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ310_RS17460	COG0765	amino acid transport
HZ310_RS17465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZ310_RS17470	COG2508	Transcriptional regulator
HZ310_RS17475	COG1012	belongs to the aldehyde dehydrogenase family
HZ310_RS17480	COG0506	proline dehydrogenase activity
HZ310_RS17485	COG3541	Predicted nucleotidyltransferase
HZ310_RS17495	COG3458	cephalosporin-C deacetylase activity
HZ310_RS17500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZ310_RS17505	COG0583	DNA-binding transcription factor activity
HZ310_RS17510	COG2226	methyltransferase
HZ310_RS17515	COG0477	Major facilitator Superfamily
HZ310_RS17525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZ310_RS17530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZ310_RS17545	COG2271	Major facilitator Superfamily
HZ310_RS17550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZ310_RS17560	COG0028	Belongs to the TPP enzyme family
HZ310_RS17565	COG0710	3-dehydroquinate dehydratase activity
HZ310_RS17570	COG1012	belongs to the aldehyde dehydrogenase family
HZ310_RS17585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HZ310_RS17590	COG3665	Urea carboxylase-associated protein
HZ310_RS17595	COG1113	amino acid transport
HZ310_RS17600	COG3403	YqcI/YcgG family
HZ310_RS17610	COG1280	lysine exporter protein (LysE YggA)
HZ310_RS17615	COG0738	Major facilitator superfamily
HZ310_RS17620	COG0673	inositol 2-dehydrogenase activity
HZ310_RS17625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZ310_RS17630	COG1609	Transcriptional regulator
HZ310_RS17635	COG1620	l-lactate permease
HZ310_RS17640	COG0039	L-malate dehydrogenase activity
HZ310_RS17645	COG1288	antiporter activity
HZ310_RS17650	COG1473	amidohydrolase
HZ310_RS17665	COG2113	Glycine betaine
HZ310_RS17670	COG4176	ABC-type proline glycine betaine transport system permease component
HZ310_RS17675	COG0517	IMP dehydrogenase activity
HZ310_RS17675	COG4175	Glycine betaine
HZ310_RS17680	COG3853	Toxic anion resistance protein (TelA)
HZ310_RS17710	COG0861	Integral membrane protein TerC family
HZ310_RS17715	COG2310	stress, protein
HZ310_RS17720	COG2310	stress, protein
HZ310_RS17725	COG2310	stress, protein
HZ310_RS17730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZ310_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS17745	COG3773	Cell wall hydrolase
HZ310_RS17760	COG1668	transmembrane transport
HZ310_RS17765	COG4555	ABC transporter
HZ310_RS17770	COG3279	Response regulator of the LytR AlgR family
HZ310_RS17775	COG3290	protein histidine kinase activity
HZ310_RS17780	COG0667	Aldo Keto reductase
HZ310_RS17790	COG1405	negative regulation of cell septum assembly
HZ310_RS17790	COG3012	SEC-C Motif Domain Protein
HZ310_RS17795	COG0784	Response regulator, receiver
HZ310_RS17800	COG4191	Histidine kinase
HZ310_RS17805	COG2066	Belongs to the glutaminase family
HZ310_RS17810	COG1115	amino acid carrier protein
HZ310_RS17815	COG0596	Alpha beta hydrolase
HZ310_RS17825	COG0531	amino acid
HZ310_RS17830	COG0318	PFAM AMP-dependent synthetase and ligase
HZ310_RS17835	COG1846	Transcriptional regulator
HZ310_RS17840	COG1063	alcohol dehydrogenase
HZ310_RS17845	COG1917	Cupin 2, conserved barrel domain protein
HZ310_RS17850	COG1309	transcriptional regulator
HZ310_RS17860	COG1404	Belongs to the peptidase S8 family
HZ310_RS17875	COG0456	acetyltransferase
HZ310_RS17880	COG2814	Major facilitator Superfamily
HZ310_RS17895	COG1695	Transcriptional regulator
HZ310_RS17900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ310_RS17905	COG2040	homocysteine
HZ310_RS17910	COG0833	amino acid
HZ310_RS17925	COG1404	Belongs to the peptidase S8 family
HZ310_RS17935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ310_RS17940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ310_RS17945	COG0383	alpha-mannosidase activity
HZ310_RS17950	COG1940	carbohydrate kinase activity
HZ310_RS17955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ310_RS17955	COG3711	transcriptional antiterminator
HZ310_RS17980	COG2723	6-phospho-beta-galactosidase activity
HZ310_RS17985	COG1263	PTS System
HZ310_RS17985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS17985	COG2190	(PTS) system
HZ310_RS17990	COG3711	transcriptional antiterminator
HZ310_RS18000	COG0531	amino acid
HZ310_RS18010	COG0371	Dehydrogenase
HZ310_RS18015	COG0656	L-ascorbic acid biosynthetic process
HZ310_RS18025	COG1683	Conserved Protein
HZ310_RS18035	COG1846	Transcriptional regulator
HZ310_RS18045	COG2814	Major facilitator Superfamily
HZ310_RS18050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZ310_RS18060	COG0730	response to heat
HZ310_RS18065	COG0425	Belongs to the sulfur carrier protein TusA family
HZ310_RS18070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ310_RS18070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ310_RS18075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ310_RS18075	COG0425	Belongs to the sulfur carrier protein TusA family
HZ310_RS18080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ310_RS18085	COG2210	Belongs to the sulfur carrier protein TusA family
HZ310_RS18090	COG1937	Protein conserved in bacteria
HZ310_RS18100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZ310_RS18105	COG1331	Highly conserved protein containing a thioredoxin domain
HZ310_RS18115	COG2271	Major facilitator Superfamily
HZ310_RS18120	COG0584	glycerophosphoryl diester phosphodiesterase
HZ310_RS18125	COG1113	amino acid transport
HZ310_RS18140	COG1309	transcriptional regulator
HZ310_RS18145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HZ310_RS18155	COG1476	TRANSCRIPTIONal
HZ310_RS18175	COG2311	Membrane
HZ310_RS18185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS18190	COG1413	lyase activity
HZ310_RS18200	COG1131	(ABC) transporter
HZ310_RS18205	COG1266	CAAX protease self-immunity
HZ310_RS18210	COG0535	radical SAM domain protein
HZ310_RS18230	COG1131	(ABC) transporter
HZ310_RS18250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZ310_RS18255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZ310_RS18260	COG4856	YbbR-like protein
HZ310_RS18265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HZ310_RS18270	COG5662	AntiSigma factor
HZ310_RS18275	COG1595	DNA-templated transcription, initiation
HZ310_RS18310	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HZ310_RS18315	COG1737	Transcriptional regulator
HZ310_RS18320	COG1263	PTS System
HZ310_RS18320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ310_RS18325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZ310_RS18330	COG1472	Belongs to the glycosyl hydrolase 3 family
HZ310_RS18335	COG3876	Protein conserved in bacteria
HZ310_RS18340	COG0385	Bile acid
HZ310_RS18345	COG0659	secondary active sulfate transmembrane transporter activity
HZ310_RS18375	COG0726	polysaccharide deacetylase
HZ310_RS18380	COG2194	sulfuric ester hydrolase activity
HZ310_RS18390	COG0489	protein tyrosine kinase activity
HZ310_RS18395	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ310_RS18425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZ310_RS18430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZ310_RS18435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZ310_RS18440	COG0101	tRNA pseudouridine synthase activity
HZ310_RS18445	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZ310_RS18450	COG1122	ATPase activity
HZ310_RS18455	COG1122	ATPase activity
HZ310_RS18460	COG0203	ribosomal protein L17
HZ310_RS18465	COG0202	RNA polymerase activity
HZ310_RS18470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HZ310_RS18475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZ310_RS18480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZ310_RS18485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZ310_RS18490	COG0024	Methionine aminopeptidase
HZ310_RS18495	COG0563	adenylate kinase activity
HZ310_RS18500	COG0201	protein transport
HZ310_RS18505	COG0200	Binds to the 23S rRNA
HZ310_RS18510	COG1841	ribosomal large subunit assembly
HZ310_RS18515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZ310_RS18520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZ310_RS18525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZ310_RS18530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZ310_RS18535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZ310_RS18540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZ310_RS18545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZ310_RS18550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HZ310_RS18555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZ310_RS18560	COG0255	Belongs to the universal ribosomal protein uL29 family
HZ310_RS18570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZ310_RS18575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZ310_RS18580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZ310_RS18585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZ310_RS18590	COG0089	rRNA binding
HZ310_RS18595	COG0088	Forms part of the polypeptide exit tunnel
HZ310_RS18600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZ310_RS18610	COG0596	Alpha beta hydrolase
HZ310_RS18615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZ310_RS18620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZ310_RS18625	COG0049	tRNA binding
HZ310_RS18630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZ310_RS18635	COG1358	cellular component organization or biogenesis
HZ310_RS18640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZ310_RS18645	COG0085	RNA polymerase activity
HZ310_RS18650	COG2813	Specifically methylates the guanine in position
HZ310_RS18655	COG0222	ribosome binding
HZ310_RS18660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZ310_RS18665	COG0081	regulation of translation
HZ310_RS18675	COG0250	Participates in transcription elongation, termination and antitermination
HZ310_RS18680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZ310_RS18685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZ310_RS18690	COG1595	DNA-templated transcription, initiation
HZ310_RS18695	COG3688	RNA-binding protein containing a PIN domain
HZ310_RS18700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZ310_RS18705	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HZ310_RS18710	COG0215	cysteine-tRNA ligase activity
HZ310_RS18715	COG1045	serine acetyltransferase
HZ310_RS18720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ310_RS18725	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZ310_RS18730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZ310_RS18735	COG4956	integral membrane protein (PIN domain superfamily)
HZ310_RS18740	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HZ310_RS18745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HZ310_RS18750	COG0542	response to heat
HZ310_RS18755	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HZ310_RS18760	COG3880	PFAM UvrB UvrC protein
HZ310_RS18765	COG4463	regulation of RNA biosynthetic process
HZ310_RS18850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZ310_RS18855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZ310_RS18860	COG1396	sequence-specific DNA binding
HZ310_RS18865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZ310_RS18870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZ310_RS18875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZ310_RS18880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZ310_RS18885	COG0512	Glutamine amidotransferase of anthranilate synthase
HZ310_RS18890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZ310_RS18895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZ310_RS18900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ310_RS18905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZ310_RS18910	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZ310_RS18915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZ310_RS18925	COG0037	tRNA processing
HZ310_RS18930	COG0515	serine threonine protein kinase
HZ310_RS18935	COG2304	oxidoreductase activity
HZ310_RS18940	COG2208	phosphoserine phosphatase activity
HZ310_RS18955	COG1098	S1 RNA binding domain
HZ310_RS18960	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HZ310_RS18975	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZ310_RS18980	COG3956	TIGRFAM MazG family protein
HZ310_RS18985	COG2244	polysaccharide biosynthetic process
HZ310_RS18990	COG2002	toxin-antitoxin pair type II binding
HZ310_RS18995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZ310_RS19005	COG0193	aminoacyl-tRNA hydrolase activity
HZ310_RS19010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZ310_RS19015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZ310_RS19025	COG2088	sporulation resulting in formation of a cellular spore
HZ310_RS19030	COG0251	oxidation-reduction process
HZ310_RS19035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ310_RS19040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZ310_RS19050	COG4466	Protein conserved in bacteria
HZ310_RS19060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZ310_RS19065	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HZ310_RS19070	COG3583	domain protein
HZ310_RS19070	COG3584	3D domain protein
HZ310_RS19075	COG0084	hydrolase, TatD family'
HZ310_RS19080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ310_RS19080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ310_RS19085	COG2002	toxin-antitoxin pair type II binding
HZ310_RS19090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZ310_RS19095	COG2827	Endonuclease containing a URI domain
HZ310_RS19100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HZ310_RS19105	COG4467	Involved in initiation control of chromosome replication
HZ310_RS19110	COG1774	PSP1 C-terminal conserved region
HZ310_RS19115	COG0470	DNA polymerase III
HZ310_RS19120	COG1728	Protein conserved in bacteria
HZ310_RS19125	COG3870	Protein conserved in bacteria
HZ310_RS19130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZ310_RS19135	COG1982	Orn Lys Arg decarboxylase major
HZ310_RS19140	COG3853	Toxic anion resistance protein (TelA)
HZ310_RS19145	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HZ310_RS19190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZ310_RS19195	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZ310_RS19200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZ310_RS19210	COG0590	tRNA wobble adenosine to inosine editing
HZ310_RS19215	COG1335	isochorismatase
HZ310_RS19220	COG3858	chitin binding
HZ310_RS19220	COG1388	LysM domain
HZ310_RS19225	COG1428	Deoxynucleoside kinase
HZ310_RS19230	COG1428	Deoxynucleoside kinase
HZ310_RS19240	COG0840	transmembrane signaling receptor activity
HZ310_RS19245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZ310_RS19250	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HZ310_RS19255	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HZ310_RS19260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ310_RS19265	COG1686	Belongs to the peptidase S11 family
HZ310_RS19270	COG0516	GMP reductase activity
HZ310_RS19270	COG0517	IMP dehydrogenase activity
HZ310_RS19305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZ310_RS19310	COG0187	DNA topoisomerase II activity
HZ310_RS19320	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZ310_RS19325	COG2501	S4 domain
HZ310_RS19330	COG0592	DNA-directed DNA polymerase activity
HZ310_RS19335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZ310_RS19340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HZ310_RS19345	COG0594	ribonuclease P activity
HZ310_RS19350	COG0706	membrane insertase activity
HZ310_RS19355	COG1847	R3H domain protein
HZ310_RS19360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZ310_RS19365	COG0445	tRNA wobble uridine modification
HZ310_RS19370	COG0357	Ribosomal RNA small subunit methyltransferase G
HZ310_RS19375	COG1475	DNA binding
HZ310_RS19385	COG1192	Involved in chromosome partitioning
HZ310_RS19390	COG1475	DNA binding
HZ310_RS19400	COG3949	Membrane
HZ310_RS19415	COG4481	Protein conserved in bacteria
HZ310_RS19420	COG0012	GTP binding
HZ310_RS19425	COG0360	Binds together with S18 to 16S ribosomal RNA
HZ310_RS19430	COG0629	single-stranded DNA binding
HZ310_RS19435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZ310_RS19440	COG0517	IMP dehydrogenase activity
HZ310_RS19440	COG1125	glycine betaine transport
HZ310_RS19445	COG1174	glycine betaine transport
HZ310_RS19450	COG0346	lactoylglutathione lyase activity
HZ310_RS19455	COG0400	carboxylic ester hydrolase activity
HZ310_RS19460	COG0655	NAD(P)H dehydrogenase (quinone) activity
HZ310_RS19465	COG0753	catalase activity
HZ310_RS19475	COG1595	DNA-templated transcription, initiation
HZ310_RS19485	COG1227	inorganic diphosphatase activity
HZ310_RS19490	COG4241	membrane
HZ310_RS19495	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HZ310_RS19500	COG0359	binds to the 23S rRNA
HZ310_RS19505	COG2807	transmembrane transport
HZ310_RS19510	COG3093	addiction module antidote protein HigA
HZ310_RS19515	COG2819	hydrolase of the alpha beta superfamily
HZ310_RS19520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ310_RS19525	COG2207	Transcriptional regulator
HZ310_RS19525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ310_RS19530	COG3251	PFAM MbtH domain protein
HZ310_RS19535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZ310_RS19540	COG3433	isochorismatase activity
HZ310_RS19540	COG1535	isochorismatase
HZ310_RS19545	COG1021	2,3-dihydroxybenzoate-AMP ligase
HZ310_RS19550	COG1169	isochorismate synthase
HZ310_RS19555	COG1028	Short-chain dehydrogenase reductase Sdr
HZ310_RS19560	COG2819	hydrolase of the alpha beta superfamily
HZ310_RS19575	COG0305	Participates in initiation and elongation during chromosome replication
HZ310_RS19580	COG0346	lactoylglutathione lyase activity
HZ310_RS19585	COG2124	cytochrome p450
HZ310_RS19595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZ310_RS19600	COG2311	Membrane
HZ310_RS19610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ310_RS19635	COG0745	RESPONSE REGULATOR receiver
HZ310_RS19640	COG5002	protein histidine kinase activity
HZ310_RS19645	COG4863	YycH protein
HZ310_RS19650	COG4853	Protein conserved in bacteria
HZ310_RS19655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZ310_RS19660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ310_RS19665	COG0456	acetyltransferase
HZ310_RS19685	COG4720	Psort location CytoplasmicMembrane, score
HZ310_RS19695	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZ310_RS19735	COG0640	Transcriptional regulator
HZ310_RS19740	COG2814	Major facilitator Superfamily
HZ310_RS19750	COG2409	Drug exporters of the RND superfamily
HZ310_RS19760	COG5002	protein histidine kinase activity
HZ310_RS19760	COG3850	Histidine kinase
HZ310_RS19775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZ310_RS19795	COG0583	DNA-binding transcription factor activity