locus-tag	class	description
DKE43_RS00005	COG3290	protein histidine kinase activity
DKE43_RS00010	COG4565	transcriptional regulatory protein
DKE43_RS00015	COG3181	Tripartite tricarboxylate transporter family receptor
DKE43_RS00020	COG2851	Citrate transporter
DKE43_RS00030	COG3479	Phenolic acid decarboxylase
DKE43_RS00035	COG1695	Transcriptional regulator
DKE43_RS00040	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DKE43_RS00045	COG1254	Belongs to the acylphosphatase family
DKE43_RS00050	COG2258	MOSC domain
DKE43_RS00060	COG0024	Methionine aminopeptidase
DKE43_RS00065	COG1263	PTS System
DKE43_RS00065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKE43_RS00070	COG3739	integral membrane protein
DKE43_RS00085	COG1368	sulfuric ester hydrolase activity
DKE43_RS00090	COG0076	glutamate decarboxylase activity
DKE43_RS00095	COG0840	transmembrane signaling receptor activity
DKE43_RS00105	COG1263	PTS System
DKE43_RS00105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKE43_RS00110	COG0366	Alpha amylase catalytic
DKE43_RS00115	COG2188	Transcriptional regulator
DKE43_RS00125	COG0737	Belongs to the 5'-nucleotidase family
DKE43_RS00130	COG0693	protein deglycase activity
DKE43_RS00135	COG4840	Belongs to the UPF0435 family
DKE43_RS00140	COG1115	amino acid carrier protein
DKE43_RS00150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKE43_RS00155	COG4980	gas vesicle protein
DKE43_RS00160	COG1295	ribonuclease BN
DKE43_RS00165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKE43_RS00170	COG0477	Major facilitator Superfamily
DKE43_RS00180	COG0387	Pfam Sodium calcium exchanger
DKE43_RS00195	COG4152	abc transporter atp-binding protein
DKE43_RS00215	COG0217	transcriptional regulatory protein
DKE43_RS00225	COG0668	transmembrane transport
DKE43_RS00230	COG0535	radical SAM domain protein
DKE43_RS00240	COG0726	polysaccharide deacetylase
DKE43_RS00250	COG0598	Magnesium transport protein CorA
DKE43_RS00260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DKE43_RS00265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DKE43_RS00275	COG0789	Transcriptional regulator
DKE43_RS00280	COG2814	Major facilitator Superfamily
DKE43_RS00295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DKE43_RS00335	COG2076	Multidrug Resistance protein
DKE43_RS00340	COG2076	Multidrug Resistance protein
DKE43_RS00345	COG1309	transcriptional regulator
DKE43_RS00355	COG4637	Psort location Cytoplasmic, score
DKE43_RS00360	COG2755	lipolytic protein G-D-S-L family
DKE43_RS00365	COG0492	ferredoxin-NADP+ reductase activity
DKE43_RS00370	COG1742	UPF0060 membrane protein
DKE43_RS00385	COG2318	DinB family
DKE43_RS00395	COG1846	Transcriptional regulator
DKE43_RS00400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DKE43_RS00400	COG0392	lysyltransferase activity
DKE43_RS00420	COG0778	Nitroreductase
DKE43_RS00435	COG1090	epimerase
DKE43_RS00440	COG2137	regulation of response to DNA damage stimulus
DKE43_RS00465	COG0463	Glycosyl transferase, family 2
DKE43_RS00470	COG4485	Bacterial membrane protein, YfhO
DKE43_RS00485	COG2140	Oxalate decarboxylase
DKE43_RS00495	COG1191	sigma factor activity
DKE43_RS00505	COG1988	membrane-bound metal-dependent
DKE43_RS00510	COG1194	a g-specific adenine glycosylase
DKE43_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS00535	COG3557	Belongs to the UPF0374 family
DKE43_RS00540	COG1132	(ABC) transporter
DKE43_RS00545	COG0444	Belongs to the ABC transporter superfamily
DKE43_RS00550	COG4608	Belongs to the ABC transporter superfamily
DKE43_RS00555	COG0747	negative chemotaxis
DKE43_RS00560	COG0601	transmembrane transport
DKE43_RS00565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DKE43_RS00570	COG4129	membrane
DKE43_RS00575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DKE43_RS00580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DKE43_RS00585	COG0735	belongs to the Fur family
DKE43_RS00725	COG1368	sulfuric ester hydrolase activity
DKE43_RS00730	COG0681	Belongs to the peptidase S26 family
DKE43_RS00735	COG2873	o-acetylhomoserine
DKE43_RS00745	COG1131	(ABC) transporter
DKE43_RS00775	COG3382	B3 4 domain protein
DKE43_RS00780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DKE43_RS00790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKE43_RS00800	COG2766	serine protein kinase
DKE43_RS00805	COG2718	Belongs to the UPF0229 family
DKE43_RS00810	COG1566	PFAM secretion protein HlyD family protein
DKE43_RS00815	COG2814	Major facilitator Superfamily
DKE43_RS00820	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE43_RS00830	COG1278	Cold shock
DKE43_RS00840	COG3706	GGDEF domain
DKE43_RS00865	COG5577	PFAM Coat F domain
DKE43_RS00870	COG5002	protein histidine kinase activity
DKE43_RS00875	COG1525	nuclease
DKE43_RS00875	COG4085	toxin activity
DKE43_RS00875	COG0737	Belongs to the 5'-nucleotidase family
DKE43_RS00880	COG3764	Sortase (surface protein transpeptidase)
DKE43_RS00885	COG0564	pseudouridine synthase activity
DKE43_RS00895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DKE43_RS00900	COG3153	acetyltransferase
DKE43_RS00900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE43_RS00915	COG3835	regulator
DKE43_RS00920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DKE43_RS00925	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DKE43_RS00930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DKE43_RS00935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DKE43_RS00940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DKE43_RS00945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DKE43_RS00950	COG2203	Gaf domain
DKE43_RS00950	COG4585	Histidine kinase
DKE43_RS00955	COG2197	response regulator
DKE43_RS00980	COG0753	catalase activity
DKE43_RS00985	COG1959	2 iron, 2 sulfur cluster binding
DKE43_RS00990	COG1017	nitric oxide dioxygenase activity
DKE43_RS00990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKE43_RS00995	COG2719	SpoVR family
DKE43_RS01000	COG1785	Belongs to the alkaline phosphatase family
DKE43_RS01005	COG0791	NLP P60 protein
DKE43_RS01005	COG1388	LysM domain
DKE43_RS01020	COG1595	DNA-templated transcription, initiation
DKE43_RS01025	COG0204	Acyl-transferase
DKE43_RS01030	COG1253	flavin adenine dinucleotide binding
DKE43_RS01035	COG0789	Transcriptional regulator
DKE43_RS01040	COG1253	flavin adenine dinucleotide binding
DKE43_RS01055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DKE43_RS01060	COG0584	glycerophosphoryl diester phosphodiesterase
DKE43_RS01070	COG0668	transmembrane transport
DKE43_RS01075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DKE43_RS01080	COG0726	polysaccharide deacetylase
DKE43_RS01090	COG0589	response to stress
DKE43_RS01095	COG1132	(ABC) transporter
DKE43_RS01100	COG1132	(ABC) transporter
DKE43_RS01105	COG0702	epimerase
DKE43_RS01115	COG3842	ATPase activity
DKE43_RS01120	COG2508	Transcriptional regulator
DKE43_RS01130	COG0189	ligase activity
DKE43_RS01135	COG0189	ligase activity
DKE43_RS01140	COG4399	Belongs to the UPF0754 family
DKE43_RS01145	COG3679	Belongs to the UPF0342 family
DKE43_RS01150	COG0561	phosphatase activity
DKE43_RS01155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKE43_RS01165	COG0475	glutathione-regulated potassium exporter activity
DKE43_RS01170	COG0490	domain, Protein
DKE43_RS01180	COG1024	Enoyl-CoA hydratase
DKE43_RS01190	COG0420	3'-5' exonuclease activity
DKE43_RS01195	COG4717	serine-type aminopeptidase activity
DKE43_RS01200	COG3481	metal-dependent phosphohydrolase, HD sub domain
DKE43_RS01210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKE43_RS01240	COG1846	Transcriptional regulator
DKE43_RS01245	COG4980	gas vesicle protein
DKE43_RS01260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DKE43_RS01265	COG0537	adenosine 5'-monophosphoramidase activity
DKE43_RS01270	COG1131	(ABC) transporter
DKE43_RS01275	COG4473	ABC transporter
DKE43_RS01285	COG1473	amidohydrolase
DKE43_RS01295	COG2329	Antibiotic biosynthesis monooxygenase
DKE43_RS01300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DKE43_RS01305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DKE43_RS01310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DKE43_RS01315	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DKE43_RS01320	COG1309	transcriptional regulator
DKE43_RS01325	COG1511	domain protein
DKE43_RS01330	COG1363	Peptidase, m42
DKE43_RS01335	COG1301	dicarboxylic acid transport
DKE43_RS01345	COG1234	tRNA 3'-trailer cleavage
DKE43_RS01350	COG0095	Lipoate-protein ligase
DKE43_RS01355	COG0318	PFAM AMP-dependent synthetase and ligase
DKE43_RS01365	COG0501	Belongs to the peptidase M48B family
DKE43_RS01370	COG1404	Belongs to the peptidase S8 family
DKE43_RS01375	COG0406	alpha-ribazole phosphatase activity
DKE43_RS01380	COG0840	transmembrane signaling receptor activity
DKE43_RS01385	COG0723	plastoquinol--plastocyanin reductase activity
DKE43_RS01385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKE43_RS01390	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS01400	COG4903	ComK protein
DKE43_RS01415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE43_RS01420	COG2814	Major facilitator Superfamily
DKE43_RS01425	COG2732	(Barnase) inhibitor
DKE43_RS01430	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE43_RS01435	COG4605	iron ion homeostasis
DKE43_RS01440	COG4604	ABC transporter, ATP-binding protein
DKE43_RS01445	COG4607	ABC-type enterochelin transport system periplasmic component
DKE43_RS01450	COG1316	TRANSCRIPTIONal
DKE43_RS01460	COG0398	Pfam SNARE associated Golgi protein
DKE43_RS01465	COG0681	Belongs to the peptidase S26 family
DKE43_RS01470	COG3180	Ammonia monooxygenase
DKE43_RS01485	COG2259	Doxx family
DKE43_RS01490	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DKE43_RS01495	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DKE43_RS01500	COG1074	ATP-dependent DNA helicase activity
DKE43_RS01505	COG0420	3'-5' exonuclease activity
DKE43_RS01510	COG0419	ATPase involved in DNA repair
DKE43_RS01515	COG1403	HNH endonuclease
DKE43_RS01555	COG5337	Spore coat protein CotH
DKE43_RS01565	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKE43_RS01580	COG0367	asparagine synthase
DKE43_RS01595	COG1562	ergosterol biosynthetic process
DKE43_RS01600	COG0534	Mate efflux family protein
DKE43_RS01605	COG2207	Transcriptional regulator
DKE43_RS01605	COG1917	Cupin 2, conserved barrel domain protein
DKE43_RS01630	COG0076	glutamate decarboxylase activity
DKE43_RS01660	COG0646	methionine synthase
DKE43_RS01660	COG1410	methionine synthase
DKE43_RS01665	COG0646	methionine synthase
DKE43_RS01665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKE43_RS01670	COG1666	GTP binding
DKE43_RS01675	COG2996	Protein conserved in bacteria
DKE43_RS01680	COG1744	ABC transporter substrate-binding protein PnrA-like
DKE43_RS01685	COG0840	transmembrane signaling receptor activity
DKE43_RS01690	COG1307	EDD domain protein, DegV family
DKE43_RS01695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DKE43_RS01715	COG0561	phosphatase activity
DKE43_RS01720	COG1073	alpha beta
DKE43_RS01725	COG2151	metal-sulfur cluster biosynthetic enzyme
DKE43_RS01730	COG0277	FAD linked oxidase domain protein
DKE43_RS01735	COG2271	Major facilitator Superfamily
DKE43_RS01740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DKE43_RS01745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DKE43_RS01750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DKE43_RS01755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE43_RS01760	COG0505	Belongs to the CarA family
DKE43_RS01765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DKE43_RS01770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DKE43_RS01780	COG2814	Major facilitator Superfamily
DKE43_RS01790	COG2267	carboxylic ester hydrolase activity
DKE43_RS01800	COG1744	ABC transporter substrate-binding protein PnrA-like
DKE43_RS01815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DKE43_RS01820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DKE43_RS01825	COG5504	Zn-dependent protease
DKE43_RS01830	COG0444	Belongs to the ABC transporter superfamily
DKE43_RS01835	COG4608	Belongs to the ABC transporter superfamily
DKE43_RS01845	COG0601	transmembrane transport
DKE43_RS01850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DKE43_RS01860	COG0180	Tryptophanyl-tRNA synthetase
DKE43_RS01865	COG4166	transmembrane transport
DKE43_RS01870	COG0601	transmembrane transport
DKE43_RS01875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DKE43_RS01880	COG0444	Belongs to the ABC transporter superfamily
DKE43_RS01885	COG4608	Belongs to the ABC transporter superfamily
DKE43_RS01895	COG0456	acetyltransferase
DKE43_RS01900	COG1393	Belongs to the ArsC family
DKE43_RS01905	COG0861	Integral membrane protein TerC family
DKE43_RS01910	COG4862	establishment of competence for transformation
DKE43_RS01915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE43_RS01925	COG1164	Oligoendopeptidase f
DKE43_RS01930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DKE43_RS01935	COG2346	COG2346, Truncated hemoglobins
DKE43_RS01940	COG0741	lytic transglycosylase activity
DKE43_RS01945	COG4116	CYTH
DKE43_RS01955	COG2357	RelA SpoT domain protein
DKE43_RS01960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKE43_RS01965	COG0564	pseudouridine synthase activity
DKE43_RS01970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DKE43_RS01975	COG0475	glutathione-regulated potassium exporter activity
DKE43_RS01975	COG0569	domain protein
DKE43_RS01980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE43_RS01985	COG0352	thiamine-phosphate diphosphorylase activity
DKE43_RS01995	COG2104	thiamine diphosphate biosynthetic process
DKE43_RS02000	COG2022	thiamine diphosphate biosynthetic process
DKE43_RS02005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DKE43_RS02010	COG0351	phosphomethylpyrimidine kinase
DKE43_RS02015	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DKE43_RS02070	COG0210	DNA helicase
DKE43_RS02080	COG2153	protein acetylation
DKE43_RS02085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DKE43_RS02090	COG2382	esterase
DKE43_RS02095	COG0626	cystathionine gamma-synthase activity
DKE43_RS02100	COG0626	cystathionine gamma-synthase activity
DKE43_RS02110	COG0604	alcohol dehydrogenase
DKE43_RS02125	COG0825	malonyl-CoA metabolic process
DKE43_RS02140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DKE43_RS02175	COG0457	Tetratricopeptide repeat
DKE43_RS02195	COG3173	Aminoglycoside phosphotransferase
DKE43_RS02215	COG0583	DNA-binding transcription factor activity
DKE43_RS02220	COG2807	transmembrane transport
DKE43_RS02230	COG0457	Tetratricopeptide repeat
DKE43_RS02250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKE43_RS02260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DKE43_RS02265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DKE43_RS02285	COG4195	phage-related replication protein
DKE43_RS02290	COG2856	Zn peptidase
DKE43_RS02295	COG5632	N-Acetylmuramoyl-L-alanine amidase
DKE43_RS02295	COG3409	Peptidoglycan-binding domain 1 protein
DKE43_RS02310	COG0306	phosphate transporter
DKE43_RS02315	COG1392	Phosphate transport regulator
DKE43_RS02325	COG0405	Gamma-glutamyltransferase
DKE43_RS02335	COG3775	system Galactitol-specific IIC component
DKE43_RS02355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE43_RS02360	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE43_RS02360	COG0022	dehydrogenase e1 component
DKE43_RS02365	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE43_RS02370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE43_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS02385	COG2390	Transcriptional regulator
DKE43_RS02395	COG0531	amino acid
DKE43_RS02400	COG0346	lactoylglutathione lyase activity
DKE43_RS02405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DKE43_RS02410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DKE43_RS02415	COG2362	D-Aminopeptidase
DKE43_RS02420	COG0601	transmembrane transport
DKE43_RS02425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DKE43_RS02430	COG0444	Belongs to the ABC transporter superfamily
DKE43_RS02435	COG4166	transmembrane transport
DKE43_RS02440	COG1619	proteins homologs of microcin C7 resistance protein MccF
DKE43_RS02445	COG4948	Mandelate Racemase Muconate Lactonizing
DKE43_RS02450	COG0791	NLP P60 protein
DKE43_RS02455	COG4608	Belongs to the ABC transporter superfamily
DKE43_RS02460	COG1834	amidinotransferase
DKE43_RS02465	COG1607	acyl-coa hydrolase
DKE43_RS02470	COG1695	Transcriptional regulator
DKE43_RS02485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKE43_RS02495	COG2076	Multidrug Resistance protein
DKE43_RS02500	COG2076	Multidrug Resistance protein
DKE43_RS02510	COG0788	formyltetrahydrofolate deformylase activity
DKE43_RS02515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DKE43_RS02520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DKE43_RS02525	COG0457	Tetratricopeptide repeat
DKE43_RS02535	COG1764	response to oxidative stress
DKE43_RS02540	COG1846	Transcriptional regulator
DKE43_RS02545	COG1764	response to oxidative stress
DKE43_RS02550	COG0590	tRNA wobble adenosine to inosine editing
DKE43_RS02555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DKE43_RS02560	COG1404	Belongs to the peptidase S8 family
DKE43_RS02565	COG0745	RESPONSE REGULATOR receiver
DKE43_RS02570	COG5002	protein histidine kinase activity
DKE43_RS02570	COG3850	Histidine kinase
DKE43_RS02575	COG3212	peptidase
DKE43_RS02580	COG3212	peptidase
DKE43_RS02590	COG2239	Acts as a magnesium transporter
DKE43_RS02605	COG0583	DNA-binding transcription factor activity
DKE43_RS02615	COG0789	Transcriptional regulator
DKE43_RS02625	COG1846	Transcriptional regulator
DKE43_RS02635	COG5001	Diguanylate cyclase
DKE43_RS02635	COG3300	MHYT domain
DKE43_RS02640	COG0586	Pfam SNARE associated Golgi protein
DKE43_RS02645	COG0861	Integral membrane protein TerC family
DKE43_RS02650	COG1191	sigma factor activity
DKE43_RS02670	COG0501	Belongs to the peptidase M48B family
DKE43_RS02675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DKE43_RS02680	COG2323	membrane
DKE43_RS02690	COG3594	Acyltransferase
DKE43_RS02695	COG5002	protein histidine kinase activity
DKE43_RS02700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKE43_RS02705	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DKE43_RS02710	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DKE43_RS02715	COG0436	Aminotransferase
DKE43_RS02720	COG1850	ribulose-bisphosphate carboxylase activity
DKE43_RS02725	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DKE43_RS02730	COG0235	Class ii aldolase
DKE43_RS02735	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DKE43_RS02745	COG3852	Histidine kinase
DKE43_RS02750	COG1846	Transcriptional regulator
DKE43_RS02755	COG1360	Flagellar Motor Protein
DKE43_RS02760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DKE43_RS02765	COG0542	response to heat
DKE43_RS02770	COG3949	Membrane
DKE43_RS02775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKE43_RS02780	COG0720	synthase
DKE43_RS02785	COG0602	queuosine metabolic process
DKE43_RS02790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DKE43_RS02800	COG4873	Protein conserved in bacteria
DKE43_RS02810	COG3773	Cell wall hydrolase
DKE43_RS02815	COG2244	polysaccharide biosynthetic process
DKE43_RS02820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKE43_RS02825	COG2217	Heavy metal translocating P-type atpase
DKE43_RS02830	COG0006	proline dipeptidase activity
DKE43_RS02835	COG1609	Transcriptional regulator
DKE43_RS02840	COG3711	transcriptional antiterminator
DKE43_RS02845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKE43_RS02845	COG1263	PTS System
DKE43_RS02845	COG2190	(PTS) system
DKE43_RS02850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS02855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DKE43_RS02865	COG1533	DNA photolyase activity
DKE43_RS02870	COG0840	transmembrane signaling receptor activity
DKE43_RS02880	COG2084	Dehydrogenase
DKE43_RS02885	COG2340	Cysteine-rich secretory protein family
DKE43_RS02890	COG0768	penicillin binding
DKE43_RS02895	COG4191	Histidine kinase
DKE43_RS02900	COG0436	Aminotransferase
DKE43_RS02905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DKE43_RS02910	COG1714	RDD family
DKE43_RS02920	COG0835	chemotaxis
DKE43_RS02920	COG0784	Response regulator, receiver
DKE43_RS02940	COG2814	Major facilitator Superfamily
DKE43_RS02945	COG1376	ErfK ybiS ycfS ynhG family protein
DKE43_RS02950	COG1408	metallophosphoesterase
DKE43_RS02955	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS02960	COG2200	EAL domain
DKE43_RS02965	COG3546	catalase activity
DKE43_RS02970	COG4703	Protein of unknown function (DUF1797)
DKE43_RS02975	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DKE43_RS02985	COG0517	IMP dehydrogenase activity
DKE43_RS02990	COG0583	DNA-binding transcription factor activity
DKE43_RS03000	COG0716	FMN binding
DKE43_RS03010	COG0716	FMN binding
DKE43_RS03015	COG2171	N-acyltransferase activity
DKE43_RS03020	COG1473	amidohydrolase
DKE43_RS03030	COG0668	transmembrane transport
DKE43_RS03035	COG0450	alkyl hydroperoxide reductase
DKE43_RS03040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKE43_RS03055	COG0746	molybdenum cofactor guanylyltransferase activity
DKE43_RS03060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DKE43_RS03065	COG0303	'Molybdopterin
DKE43_RS03070	COG1763	Mo-molybdopterin cofactor biosynthetic process
DKE43_RS03075	COG0314	molybdopterin synthase activity
DKE43_RS03080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DKE43_RS03095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKE43_RS03100	COG1136	(ABC) transporter
DKE43_RS03105	COG0577	efflux transmembrane transporter activity
DKE43_RS03110	COG1349	DNA-binding transcription factor activity
DKE43_RS03115	COG1105	Belongs to the carbohydrate kinase PfkB family
DKE43_RS03120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE43_RS03120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS03120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE43_RS03135	COG0488	(ABC) transporter
DKE43_RS03140	COG2309	aminopeptidase activity
DKE43_RS03145	COG1077	Cell shape determining protein MreB Mrl
DKE43_RS03150	COG2002	toxin-antitoxin pair type II binding
DKE43_RS03155	COG3852	Histidine kinase
DKE43_RS03160	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DKE43_RS03160	COG2105	PFAM AIG2 family protein
DKE43_RS03165	COG0569	domain protein
DKE43_RS03170	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DKE43_RS03175	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DKE43_RS03180	COG5503	Protein of unknown function (DUF1447)
DKE43_RS03185	COG0561	phosphatase activity
DKE43_RS03190	COG0242	peptide deformylase activity
DKE43_RS03205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE43_RS03210	COG0022	dehydrogenase e1 component
DKE43_RS03215	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE43_RS03220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE43_RS03225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKE43_RS03240	COG1982	Orn Lys Arg decarboxylase major
DKE43_RS03245	COG4476	Belongs to the UPF0223 family
DKE43_RS03250	COG4493	Belongs to the UPF0637 family
DKE43_RS03260	COG0483	inositol monophosphate 1-phosphatase activity
DKE43_RS03275	COG1595	DNA-templated transcription, initiation
DKE43_RS03295	COG1217	gtp-binding protein TYPA
DKE43_RS03305	COG4896	Protein conserved in bacteria
DKE43_RS03315	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DKE43_RS03320	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DKE43_RS03325	COG2066	Belongs to the glutaminase family
DKE43_RS03330	COG4838	Belongs to the UPF0358 family
DKE43_RS03335	COG0772	Belongs to the SEDS family
DKE43_RS03340	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DKE43_RS03345	COG0415	Belongs to the DNA photolyase family
DKE43_RS03350	COG1612	heme a metabolic process
DKE43_RS03355	COG0109	protoheme IX farnesyltransferase activity
DKE43_RS03360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DKE43_RS03360	COG2010	Cytochrome c
DKE43_RS03365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKE43_RS03370	COG1845	cytochrome c oxidase, subunit III
DKE43_RS03375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE43_RS03380	COG3336	cytochrome c oxidase
DKE43_RS03395	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DKE43_RS03400	COG2340	Cysteine-rich secretory protein family
DKE43_RS03420	COG3679	Belongs to the UPF0342 family
DKE43_RS03425	COG4471	UPF0298 protein
DKE43_RS03430	COG0742	ribosomal rna small subunit methyltransferase
DKE43_RS03435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DKE43_RS03440	COG3314	Sporulation integral membrane protein YlbJ
DKE43_RS03445	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKE43_RS03450	COG3480	Lon protease (S16) C-terminal proteolytic domain
DKE43_RS03460	COG1399	metal-binding, possibly nucleic acid-binding protein
DKE43_RS03465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DKE43_RS03475	COG0454	-acetyltransferase
DKE43_RS03480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DKE43_RS03485	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DKE43_RS03490	COG2001	Belongs to the MraZ family
DKE43_RS03495	COG0275	rRNA processing
DKE43_RS03500	COG4839	cell division protein FtsL
DKE43_RS03505	COG0768	penicillin binding
DKE43_RS03515	COG0768	penicillin binding
DKE43_RS03520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DKE43_RS03525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DKE43_RS03530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DKE43_RS03535	COG0772	Belongs to the SEDS family
DKE43_RS03540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DKE43_RS03545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DKE43_RS03550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DKE43_RS03555	COG3879	Bacterial protein of unknown function (DUF881)
DKE43_RS03560	COG3879	Bacterial protein of unknown function (DUF881)
DKE43_RS03565	COG3856	small basic protein
DKE43_RS03570	COG0849	cell division
DKE43_RS03575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DKE43_RS03580	COG4412	M6 family metalloprotease domain protein
DKE43_RS03580	COG1404	Belongs to the peptidase S8 family
DKE43_RS03590	COG1191	sigma factor activity
DKE43_RS03595	COG1191	sigma factor activity
DKE43_RS03600	COG2390	Transcriptional regulator
DKE43_RS03615	COG3730	PTS system glucitol sorbitol-specific
DKE43_RS03620	COG3732	PTS system glucitol sorbitol-specific
DKE43_RS03630	COG1119	ATPase activity
DKE43_RS03635	COG1873	PFAM PRC-barrel domain
DKE43_RS03640	COG1496	oxidoreductase activity
DKE43_RS03645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DKE43_RS03650	COG1799	cell septum assembly
DKE43_RS03655	COG0762	integral membrane protein
DKE43_RS03660	COG2302	S4 RNA-binding domain
DKE43_RS03665	COG3599	regulation of cell shape
DKE43_RS03670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DKE43_RS03675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE43_RS03680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DKE43_RS03685	COG0564	pseudouridine synthase activity
DKE43_RS03690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DKE43_RS03695	COG2233	PERMEase
DKE43_RS03700	COG0540	Belongs to the ATCase OTCase family
DKE43_RS03705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DKE43_RS03710	COG0505	Belongs to the CarA family
DKE43_RS03715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DKE43_RS03720	COG0543	2 iron, 2 sulfur cluster binding
DKE43_RS03725	COG0167	dihydroorotate dehydrogenase activity
DKE43_RS03730	COG0284	orotidine-5'-phosphate decarboxylase activity
DKE43_RS03735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DKE43_RS03745	COG0175	sulfate reduction
DKE43_RS03750	COG0306	phosphate transporter
DKE43_RS03755	COG2046	Belongs to the sulfate adenylyltransferase family
DKE43_RS03760	COG0529	Catalyzes the synthesis of activated sulfate
DKE43_RS03765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DKE43_RS03770	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DKE43_RS03775	COG1648	precorrin-2 dehydrogenase activity
DKE43_RS03785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DKE43_RS03790	COG1561	YicC-like family, N-terminal region
DKE43_RS03795	COG2052	Domain of unknown function (DUF370)
DKE43_RS03800	COG0194	GDP metabolic process
DKE43_RS03805	COG1758	RNA polymerase activity
DKE43_RS03810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKE43_RS03815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DKE43_RS03820	COG0242	peptide deformylase activity
DKE43_RS03825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DKE43_RS03830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DKE43_RS03830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DKE43_RS03835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DKE43_RS03840	COG0631	protein serine/threonine phosphatase activity
DKE43_RS03845	COG0515	serine threonine protein kinase
DKE43_RS03845	COG2815	serine threonine protein kinase
DKE43_RS03850	COG1162	GTPase activity
DKE43_RS03855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKE43_RS03860	COG1564	THIamine pyrophosphokinase
DKE43_RS03870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DKE43_RS03875	COG1302	Protein conserved in bacteria
DKE43_RS03880	COG1461	Dihydroxyacetone kinase
DKE43_RS03885	COG1760	l-serine dehydratase
DKE43_RS03890	COG1760	l-serine dehydratase
DKE43_RS03895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DKE43_RS03900	COG1349	DNA-binding transcription factor activity
DKE43_RS03905	COG0416	fatty acid biosynthetic process
DKE43_RS03910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DKE43_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS03920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE43_RS03930	COG1196	nuclear chromosome segregation
DKE43_RS03935	COG0552	protein localization to endoplasmic reticulum
DKE43_RS03940	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DKE43_RS03945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DKE43_RS03950	COG0228	four-way junction DNA binding
DKE43_RS03955	COG1837	Belongs to the UPF0109 family
DKE43_RS03965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKE43_RS03970	COG0336	Belongs to the RNA methyltransferase TrmD family
DKE43_RS03975	COG0335	large ribosomal subunit rRNA binding
DKE43_RS03980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DKE43_RS03985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DKE43_RS03995	COG2257	FlhB HrpN YscU SpaS Family
DKE43_RS04000	COG0045	succinate-CoA ligase (ADP-forming) activity
DKE43_RS04005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DKE43_RS04010	COG0758	DNA mediated transformation
DKE43_RS04015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DKE43_RS04020	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DKE43_RS04025	COG4974	Belongs to the 'phage' integrase family
DKE43_RS04030	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DKE43_RS04035	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DKE43_RS04040	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DKE43_RS04045	COG1815	bacterial-type flagellum-dependent cell motility
DKE43_RS04050	COG1558	bacterial-type flagellum-dependent cell motility
DKE43_RS04055	COG1677	Flagellar hook-basal body complex protein FliE
DKE43_RS04060	COG1766	The M ring may be actively involved in energy transduction
DKE43_RS04065	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DKE43_RS04070	COG1317	bacterial-type flagellum organization
DKE43_RS04075	COG1157	protein secretion by the type III secretion system
DKE43_RS04080	COG2882	bacterial-type flagellum organization
DKE43_RS04085	COG3334	PFAM MgtE intracellular
DKE43_RS04090	COG3144	bacterial-type flagellum assembly
DKE43_RS04095	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DKE43_RS04100	COG4786	Flagellar basal body rod
DKE43_RS04105	COG1582	Flagellar protein (FlbD)
DKE43_RS04110	COG1580	Controls the rotational direction of flagella during chemotaxis
DKE43_RS04115	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DKE43_RS04120	COG1776	CheC inhibitor of MCP methylation
DKE43_RS04120	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DKE43_RS04125	COG2201	protein-glutamate methylesterase activity
DKE43_RS04130	COG3190	flagellar
DKE43_RS04135	COG1338	Plays a role in the flagellum-specific transport system
DKE43_RS04140	COG1987	bacterial-type flagellum assembly
DKE43_RS04145	COG1684	flagellar biosynthetic protein fliR
DKE43_RS04150	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DKE43_RS04155	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DKE43_RS04160	COG1419	protein localization to endoplasmic reticulum
DKE43_RS04165	COG0455	bacterial-type flagellum organization
DKE43_RS04170	COG2201	protein-glutamate methylesterase activity
DKE43_RS04175	COG0643	Histidine kinase
DKE43_RS04175	COG2198	Histidine kinase
DKE43_RS04180	COG0835	chemotaxis
DKE43_RS04185	COG1776	CheC inhibitor of MCP methylation
DKE43_RS04195	COG1191	sigma factor activity
DKE43_RS04205	COG0052	Belongs to the universal ribosomal protein uS2 family
DKE43_RS04210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DKE43_RS04215	COG0528	UMP kinase activity
DKE43_RS04220	COG0233	cytoplasmic translational termination
DKE43_RS04225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DKE43_RS04230	COG4589	Belongs to the CDS family
DKE43_RS04235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DKE43_RS04240	COG0750	zinc metalloprotease
DKE43_RS04245	COG0442	prolyl-tRNA aminoacylation
DKE43_RS04250	COG2176	DNA-directed DNA polymerase activity
DKE43_RS04265	COG3693	PFAM glycoside hydrolase, family 10
DKE43_RS04275	COG0779	Required for maturation of 30S ribosomal subunits
DKE43_RS04280	COG0195	Participates in both transcription termination and antitermination
DKE43_RS04285	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DKE43_RS04290	COG1358	cellular component organization or biogenesis
DKE43_RS04295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DKE43_RS04300	COG1550	Protein conserved in bacteria
DKE43_RS04305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DKE43_RS04310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DKE43_RS04315	COG0196	riboflavin kinase activity
DKE43_RS04320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DKE43_RS04325	COG1185	polyribonucleotide nucleotidyltransferase activity
DKE43_RS04330	COG0726	polysaccharide deacetylase
DKE43_RS04335	COG0612	Peptidase, M16
DKE43_RS04345	COG1873	PFAM PRC-barrel domain
DKE43_RS04350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DKE43_RS04355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKE43_RS04360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DKE43_RS04365	COG0527	aspartate kinase activity
DKE43_RS04375	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DKE43_RS04380	COG0740	serine-type endopeptidase activity
DKE43_RS04390	COG4980	gas vesicle protein
DKE43_RS04390	COG1674	ftsk spoiiie
DKE43_RS04395	COG2188	Transcriptional regulator
DKE43_RS04400	COG2814	Major facilitator Superfamily
DKE43_RS04405	COG1033	growth of symbiont in host cell
DKE43_RS04405	COG2409	Drug exporters of the RND superfamily
DKE43_RS04410	COG0612	Peptidase, M16
DKE43_RS04415	COG0612	Peptidase, M16
DKE43_RS04425	COG2409	Drug exporters of the RND superfamily
DKE43_RS04425	COG1033	growth of symbiont in host cell
DKE43_RS04430	COG0300	oxidoreductase activity
DKE43_RS04445	COG1426	Protein conserved in bacteria
DKE43_RS04450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKE43_RS04455	COG1546	Belongs to the CinA family
DKE43_RS04455	COG1058	Belongs to the CinA family
DKE43_RS04460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DKE43_RS04465	COG1418	mRNA catabolic process
DKE43_RS04470	COG1692	metallophosphoesterase
DKE43_RS04475	COG2359	stage V sporulation protein S
DKE43_RS04480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKE43_RS04485	COG1063	alcohol dehydrogenase
DKE43_RS04490	COG0156	8-amino-7-oxononanoate synthase activity
DKE43_RS04500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DKE43_RS04505	COG4550	Control of competence regulator ComK, YlbF/YmcA
DKE43_RS04515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DKE43_RS04520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DKE43_RS04545	COG1329	Transcriptional regulator
DKE43_RS04550	COG4195	phage-related replication protein
DKE43_RS04555	COG0457	Tetratricopeptide repeat
DKE43_RS04560	COG1404	Belongs to the peptidase S8 family
DKE43_RS04565	COG4195	phage-related replication protein
DKE43_RS04570	COG1764	response to oxidative stress
DKE43_RS04575	COG2076	Multidrug Resistance protein
DKE43_RS04600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DKE43_RS04605	COG1923	regulation of RNA biosynthetic process
DKE43_RS04620	COG1780	Probably involved in ribonucleotide reductase function
DKE43_RS04625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKE43_RS04630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKE43_RS04635	COG4112	unkown
DKE43_RS04645	COG0464	growth
DKE43_RS04650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DKE43_RS04655	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DKE43_RS04660	COG0789	Transcriptional regulator
DKE43_RS04665	COG0174	glutamine synthetase
DKE43_RS04675	COG0457	Tetratricopeptide repeat
DKE43_RS04680	COG5444	nuclease activity
DKE43_RS04705	COG5646	InterPro IPR014922
DKE43_RS04720	COG0457	Tetratricopeptide repeat
DKE43_RS04730	COG3619	membrane
DKE43_RS04735	COG1793	dna ligase
DKE43_RS04735	COG3285	dna ligase
DKE43_RS04740	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DKE43_RS04745	COG4876	unkown
DKE43_RS04755	COG1959	2 iron, 2 sulfur cluster binding
DKE43_RS04760	COG0702	epimerase
DKE43_RS04765	COG0247	lactate metabolic process
DKE43_RS04770	COG1139	Iron-sulfur cluster binding protein
DKE43_RS04775	COG1556	Lactate utilization protein
DKE43_RS04800	COG1309	transcriptional regulator
DKE43_RS04805	COG2124	cytochrome p450
DKE43_RS04805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DKE43_RS04815	COG3591	Belongs to the peptidase S1B family
DKE43_RS04820	COG3209	COG3209 Rhs family protein
DKE43_RS04825	COG1366	Belongs to the anti-sigma-factor antagonist family
DKE43_RS04840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKE43_RS04845	COG1388	LysM domain
DKE43_RS04850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DKE43_RS04855	COG4224	UPF0291 protein
DKE43_RS04860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DKE43_RS04870	COG3763	UPF0154 protein
DKE43_RS04880	COG0785	Cytochrome C biogenesis protein
DKE43_RS04885	COG4846	Membrane protein involved in cytochrome C biogenesis
DKE43_RS04895	COG0071	Belongs to the small heat shock protein (HSP20) family
DKE43_RS04910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DKE43_RS04915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKE43_RS04935	COG0824	Thioesterase
DKE43_RS04945	COG4841	protein insertion into membrane
DKE43_RS04950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DKE43_RS04955	COG1832	CoA-binding protein
DKE43_RS04960	COG0187	DNA topoisomerase II activity
DKE43_RS04965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DKE43_RS04975	COG0738	Major facilitator superfamily
DKE43_RS04980	COG0473	3-isopropylmalate dehydrogenase activity
DKE43_RS04990	COG0583	DNA-binding transcription factor activity
DKE43_RS05015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKE43_RS05020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DKE43_RS05025	COG0640	Transcriptional regulator
DKE43_RS05030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DKE43_RS05035	COG0251	oxidation-reduction process
DKE43_RS05065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DKE43_RS05085	COG0657	acetylesterase activity
DKE43_RS05100	COG2205	protein histidine kinase activity
DKE43_RS05105	COG0745	RESPONSE REGULATOR receiver
DKE43_RS05115	COG3507	Belongs to the glycosyl hydrolase 43 family
DKE43_RS05120	COG1012	belongs to the aldehyde dehydrogenase family
DKE43_RS05125	COG1486	melibiose metabolic process
DKE43_RS05130	COG0395	ABC-type sugar transport system, permease component
DKE43_RS05135	COG1175	transmembrane transport
DKE43_RS05140	COG1653	transport
DKE43_RS05145	COG1609	Transcriptional regulator
DKE43_RS05150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKE43_RS05165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS05175	COG1846	Transcriptional regulator
DKE43_RS05180	COG2814	Major facilitator Superfamily
DKE43_RS05190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE43_RS05190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE43_RS05190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE43_RS05195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE43_RS05195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS05200	COG1105	Belongs to the carbohydrate kinase PfkB family
DKE43_RS05210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE43_RS05240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DKE43_RS05245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE43_RS05250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE43_RS05255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DKE43_RS05260	COG1024	Enoyl-CoA hydratase
DKE43_RS05265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DKE43_RS05270	COG0511	ligase activity, forming carbon-carbon bonds
DKE43_RS05275	COG0439	Biotin carboxylase
DKE43_RS05280	COG0318	PFAM AMP-dependent synthetase and ligase
DKE43_RS05285	COG1960	acyl-CoA dehydrogenase activity
DKE43_RS05290	COG1649	PFAM Uncharacterised BCR, COG1649
DKE43_RS05295	COG2365	Tyrosine phosphatase family
DKE43_RS05300	COG1349	DNA-binding transcription factor activity
DKE43_RS05315	COG0277	FAD linked oxidase domain protein
DKE43_RS05320	COG0247	lactate metabolic process
DKE43_RS05345	COG0166	Belongs to the GPI family
DKE43_RS05355	COG0586	Pfam SNARE associated Golgi protein
DKE43_RS05360	COG1587	Uroporphyrinogen-III synthase
DKE43_RS05370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE43_RS05390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE43_RS05395	COG1846	Transcriptional regulator
DKE43_RS05405	COG2085	NADP oxidoreductase coenzyme F420-dependent
DKE43_RS05425	COG0534	Mate efflux family protein
DKE43_RS05430	COG2027	D-alanyl-D-alanine carboxypeptidase
DKE43_RS05435	COG4677	pectinesterase activity
DKE43_RS05440	COG2323	membrane
DKE43_RS05445	COG2146	nitrite reductase [NAD(P)H] activity
DKE43_RS05450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE43_RS05455	COG0243	molybdopterin cofactor binding
DKE43_RS05460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKE43_RS05465	COG2223	nitrite transmembrane transporter activity
DKE43_RS05470	COG0493	'glutamate synthase
DKE43_RS05475	COG0067	glutamate synthase
DKE43_RS05475	COG0069	glutamate synthase activity
DKE43_RS05475	COG0070	glutamate synthase
DKE43_RS05480	COG0583	DNA-binding transcription factor activity
DKE43_RS05500	COG0454	-acetyltransferase
DKE43_RS05505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DKE43_RS05510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DKE43_RS05525	COG0243	molybdopterin cofactor binding
DKE43_RS05535	COG1070	Carbohydrate kinase
DKE43_RS05540	COG2115	Belongs to the xylose isomerase family
DKE43_RS05545	COG1940	carbohydrate kinase activity
DKE43_RS05555	COG2211	Major facilitator Superfamily
DKE43_RS05560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE43_RS05565	COG1994	Peptidase M50
DKE43_RS05585	COG1309	transcriptional regulator
DKE43_RS05590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE43_RS05595	COG3708	Transcriptional regulator
DKE43_RS05600	COG2378	regulation of single-species biofilm formation
DKE43_RS05610	COG0640	Transcriptional regulator
DKE43_RS05615	COG0531	amino acid
DKE43_RS05620	COG0741	lytic transglycosylase activity
DKE43_RS05625	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DKE43_RS05630	COG2079	MmgE PrpD family protein
DKE43_RS05635	COG0372	Belongs to the citrate synthase family
DKE43_RS05640	COG2322	membrane
DKE43_RS05650	COG3584	3D domain protein
DKE43_RS05650	COG1388	LysM domain
DKE43_RS05655	COG0514	ATP-dependent DNA helicase (RecQ)
DKE43_RS05665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE43_RS05690	COG1012	belongs to the aldehyde dehydrogenase family
DKE43_RS05695	COG1657	PFAM Prenyltransferase squalene oxidase
DKE43_RS05700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE43_RS05705	COG0385	Bile acid
DKE43_RS05710	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE43_RS05715	COG0567	Dehydrogenase, E1 component
DKE43_RS05720	COG4548	von Willebrand factor, type A
DKE43_RS05725	COG0714	Associated with various cellular activities
DKE43_RS05730	COG2032	superoxide dismutase activity
DKE43_RS05735	COG1388	LysM domain
DKE43_RS05735	COG0791	NLP P60 protein
DKE43_RS05740	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DKE43_RS05745	COG0534	Mate efflux family protein
DKE43_RS05750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DKE43_RS05755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DKE43_RS05765	COG2962	Rard protein
DKE43_RS05780	COG1733	regulation of RNA biosynthetic process
DKE43_RS05785	COG0778	Nitroreductase
DKE43_RS05795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE43_RS05800	COG0793	Belongs to the peptidase S41A family
DKE43_RS05800	COG3409	Peptidoglycan-binding domain 1 protein
DKE43_RS05805	COG2226	methyltransferase
DKE43_RS05815	COG1876	peptidase activity
DKE43_RS05820	COG0813	purine-nucleoside phosphorylase activity
DKE43_RS05830	COG0671	phosphoesterase, PA-phosphatase related
DKE43_RS05845	COG4479	Belongs to the UPF0346 family
DKE43_RS05855	COG1509	lysine 2,3-aminomutase activity
DKE43_RS05860	COG3829	transcription factor binding
DKE43_RS05865	COG0463	Glycosyl transferase, family 2
DKE43_RS05880	COG4641	Protein conserved in bacteria
DKE43_RS05890	COG1086	Polysaccharide biosynthesis protein
DKE43_RS05895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKE43_RS05900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKE43_RS05905	COG1846	Transcriptional regulator
DKE43_RS05925	COG4698	Protein conserved in bacteria
DKE43_RS05930	COG2755	lipolytic protein G-D-S-L family
DKE43_RS05935	COG1999	signal sequence binding
DKE43_RS05950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DKE43_RS05955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DKE43_RS05960	COG1272	protein, Hemolysin III
DKE43_RS05965	COG0204	Acyl-transferase
DKE43_RS05970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DKE43_RS05975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DKE43_RS05980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DKE43_RS05995	COG2136	Putative SAM-dependent methyltransferase
DKE43_RS05995	COG2521	methyltransferase
DKE43_RS06005	COG0129	dihydroxy-acid dehydratase activity
DKE43_RS06010	COG1413	lyase activity
DKE43_RS06015	COG1418	mRNA catabolic process
DKE43_RS06020	COG0386	Belongs to the glutathione peroxidase family
DKE43_RS06025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DKE43_RS06030	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DKE43_RS06035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DKE43_RS06045	COG1278	Cold shock
DKE43_RS06060	COG0328	RNA-DNA hybrid ribonuclease activity
DKE43_RS06065	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DKE43_RS06070	COG0328	RNA-DNA hybrid ribonuclease activity
DKE43_RS06080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DKE43_RS06090	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DKE43_RS06100	COG1755	Isoprenylcysteine carboxyl methyltransferase
DKE43_RS06105	COG3424	synthase
DKE43_RS06115	COG2233	PERMEase
DKE43_RS06120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DKE43_RS06125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DKE43_RS06130	COG1199	ATP-dependent helicase activity
DKE43_RS06140	COG0116	Belongs to the methyltransferase superfamily
DKE43_RS06150	COG3599	regulation of cell shape
DKE43_RS06165	COG3359	exonuclease
DKE43_RS06170	COG1111	helicase
DKE43_RS06170	COG1205	dead DEAH box helicase
DKE43_RS06175	COG1902	pentaerythritol trinitrate reductase activity
DKE43_RS06180	COG2190	(PTS) system
DKE43_RS06185	COG0071	Belongs to the small heat shock protein (HSP20) family
DKE43_RS06215	COG3331	DNA recombination
DKE43_RS06220	COG4499	WXG100 protein secretion system (Wss), protein YukC
DKE43_RS06220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DKE43_RS06230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DKE43_RS06235	COG3935	DnaD domain protein
DKE43_RS06240	COG0017	Asparaginyl-tRNA synthetase
DKE43_RS06245	COG5353	protein conserved in bacteria
DKE43_RS06255	COG1199	ATP-dependent helicase activity
DKE43_RS06255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKE43_RS06260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DKE43_RS06265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DKE43_RS06270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DKE43_RS06280	COG0617	tRNA 3'-terminal CCA addition
DKE43_RS06285	COG0438	transferase activity, transferring glycosyl groups
DKE43_RS06290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DKE43_RS06295	COG1803	Methylglyoxal synthase
DKE43_RS06300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DKE43_RS06305	COG1694	Mazg nucleotide pyrophosphohydrolase
DKE43_RS06310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DKE43_RS06320	COG4347	Protein of unknown function (DUF1405)
DKE43_RS06325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DKE43_RS06325	COG2010	Cytochrome c
DKE43_RS06330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DKE43_RS06335	COG0723	plastoquinol--plastocyanin reductase activity
DKE43_RS06345	COG5582	Belongs to the UPF0302 family
DKE43_RS06350	COG0457	Tetratricopeptide repeat
DKE43_RS06355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DKE43_RS06360	COG0287	Prephenate dehydrogenase
DKE43_RS06365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DKE43_RS06370	COG0159	tryptophan synthase activity
DKE43_RS06375	COG0133	tryptophan synthase activity
DKE43_RS06380	COG0135	phosphoribosylanthranilate isomerase activity
DKE43_RS06385	COG0134	indole-3-glycerol-phosphate synthase activity
DKE43_RS06390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DKE43_RS06400	COG4401	Chorismate mutase type I
DKE43_RS06405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DKE43_RS06410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DKE43_RS06415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DKE43_RS06420	COG0105	UTP biosynthetic process
DKE43_RS06425	COG0142	geranyltranstransferase activity
DKE43_RS06430	COG2226	methyltransferase
DKE43_RS06435	COG0142	geranyltranstransferase activity
DKE43_RS06445	COG0302	gtp cyclohydrolase
DKE43_RS06450	COG0776	regulation of translation
DKE43_RS06455	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DKE43_RS06470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DKE43_RS06475	COG1160	GTP binding
DKE43_RS06500	COG1304	FMN binding
DKE43_RS06505	COG0539	negative regulation of cytoplasmic translation
DKE43_RS06510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DKE43_RS06520	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DKE43_RS06525	COG2959	enzyme of heme biosynthesis
DKE43_RS06530	COG3773	Cell wall hydrolase
DKE43_RS06530	COG3409	Peptidoglycan-binding domain 1 protein
DKE43_RS06535	COG2339	peptidase activity
DKE43_RS06540	COG0492	ferredoxin-NADP+ reductase activity
DKE43_RS06545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKE43_RS06550	COG4862	establishment of competence for transformation
DKE43_RS06555	COG1408	metallophosphoesterase
DKE43_RS06565	COG1388	LysM domain
DKE43_RS06570	COG1266	CAAX protease self-immunity
DKE43_RS06575	COG0514	ATP-dependent DNA helicase (RecQ)
DKE43_RS06580	COG4955	Helix-turn-helix domain
DKE43_RS06585	COG1141	Ferredoxin
DKE43_RS06590	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DKE43_RS06595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DKE43_RS06600	COG5632	N-Acetylmuramoyl-L-alanine amidase
DKE43_RS06600	COG3409	Peptidoglycan-binding domain 1 protein
DKE43_RS06610	COG1595	DNA-templated transcription, initiation
DKE43_RS06615	COG5002	protein histidine kinase activity
DKE43_RS06620	COG0745	RESPONSE REGULATOR receiver
DKE43_RS06625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DKE43_RS06630	COG1333	cytochrome c biogenesis protein
DKE43_RS06635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKE43_RS06640	COG1187	pseudouridine synthase activity
DKE43_RS06645	COG0700	Nucleoside recognition
DKE43_RS06650	COG2715	membrane protein required for spore maturation
DKE43_RS06655	COG1686	Belongs to the peptidase S11 family
DKE43_RS06665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKE43_RS06670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DKE43_RS06680	COG1547	Domain of unknown function (DUF309)
DKE43_RS06685	COG0456	acetyltransferase
DKE43_RS06690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DKE43_RS06695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE43_RS06695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE43_RS06700	COG0307	riboflavin synthase, alpha
DKE43_RS06725	COG2814	Major facilitator Superfamily
DKE43_RS06730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DKE43_RS06735	COG4086	secreted protein
DKE43_RS06740	COG0019	diaminopimelate decarboxylase activity
DKE43_RS06745	COG0697	spore germination
DKE43_RS06760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DKE43_RS06780	COG1191	sigma factor activity
DKE43_RS06785	COG2172	sigma factor antagonist activity
DKE43_RS06795	COG1686	Belongs to the peptidase S11 family
DKE43_RS06800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DKE43_RS06805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DKE43_RS06810	COG4974	Belongs to the 'phage' integrase family
DKE43_RS06820	COG0735	belongs to the Fur family
DKE43_RS06825	COG1300	Membrane
DKE43_RS06830	COG1404	Belongs to the peptidase S8 family
DKE43_RS06840	COG2153	protein acetylation
DKE43_RS06845	COG1379	DNA repair
DKE43_RS06850	COG0494	nUDIX hydrolase
DKE43_RS06855	COG0667	Aldo Keto reductase
DKE43_RS06870	COG1073	alpha beta
DKE43_RS06875	COG0457	Tetratricopeptide repeat
DKE43_RS06885	COG4918	Iron-sulphur cluster biosynthesis
DKE43_RS06890	COG4305	rare lipoprotein A
DKE43_RS06895	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DKE43_RS06895	COG0456	acetyltransferase
DKE43_RS06900	COG0456	acetyltransferase
DKE43_RS06910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKE43_RS06920	COG2211	Major facilitator Superfamily
DKE43_RS06925	COG1072	(Pantothenic acid kinase))
DKE43_RS06930	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKE43_RS06935	COG0300	oxidoreductase activity
DKE43_RS06940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE43_RS06945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DKE43_RS06955	COG4187	Peptidase family M20/M25/M40
DKE43_RS06960	COG1902	pentaerythritol trinitrate reductase activity
DKE43_RS06965	COG0596	Alpha beta hydrolase
DKE43_RS06970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE43_RS06975	COG1234	tRNA 3'-trailer cleavage
DKE43_RS06980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DKE43_RS06985	COG2188	Transcriptional regulator
DKE43_RS06990	COG2723	6-phospho-beta-galactosidase activity
DKE43_RS06995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DKE43_RS07000	COG1447	Phosphotransferase system cellobiose-specific component IIA
DKE43_RS07005	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DKE43_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS07015	COG4975	Glucose uptake
DKE43_RS07020	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DKE43_RS07025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKE43_RS07035	COG0706	membrane insertase activity
DKE43_RS07045	COG2195	Cleaves the N-terminal amino acid of tripeptides
DKE43_RS07050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DKE43_RS07055	COG0346	lactoylglutathione lyase activity
DKE43_RS07060	COG1376	ErfK ybiS ycfS ynhG family protein
DKE43_RS07065	COG4129	membrane
DKE43_RS07070	COG1126	abc transporter atp-binding protein
DKE43_RS07075	COG0765	amino acid transport
DKE43_RS07080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE43_RS07090	COG1597	lipid kinase activity
DKE43_RS07100	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE43_RS07105	COG0022	dehydrogenase e1 component
DKE43_RS07110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE43_RS07115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE43_RS07120	COG3426	butyrate kinase activity
DKE43_RS07125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKE43_RS07130	COG0280	phosphate acetyltransferase
DKE43_RS07135	COG3829	transcription factor binding
DKE43_RS07135	COG3290	protein histidine kinase activity
DKE43_RS07145	COG0584	glycerophosphoryl diester phosphodiesterase
DKE43_RS07150	COG0457	Tetratricopeptide repeat
DKE43_RS07160	COG0745	RESPONSE REGULATOR receiver
DKE43_RS07165	COG0750	zinc metalloprotease
DKE43_RS07170	COG0497	DNA recombination
DKE43_RS07175	COG1438	arginine binding
DKE43_RS07180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DKE43_RS07185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DKE43_RS07190	COG0142	geranyltranstransferase activity
DKE43_RS07195	COG1722	exodeoxyribonuclease VII activity
DKE43_RS07200	COG1570	exodeoxyribonuclease VII activity
DKE43_RS07205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DKE43_RS07210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DKE43_RS07215	COG1302	Protein conserved in bacteria
DKE43_RS07220	COG0439	Biotin carboxylase
DKE43_RS07225	COG0511	ligase activity, forming carbon-carbon bonds
DKE43_RS07265	COG3854	ATPases associated with a variety of cellular activities
DKE43_RS07280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DKE43_RS07285	COG0006	proline dipeptidase activity
DKE43_RS07290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DKE43_RS07300	COG3872	metal-dependent enzyme
DKE43_RS07310	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKE43_RS07315	COG1321	iron dependent repressor
DKE43_RS07320	COG0095	Lipoate-protein ligase
DKE43_RS07325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DKE43_RS07330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DKE43_RS07335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DKE43_RS07340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DKE43_RS07345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DKE43_RS07370	COG0681	Belongs to the peptidase S26 family
DKE43_RS07405	COG4970	Tfp pilus assembly protein FimT
DKE43_RS07410	COG4537	Required for transformation and DNA binding
DKE43_RS07415	COG1459	type II secretion system
DKE43_RS07420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DKE43_RS07425	COG1366	Belongs to the anti-sigma-factor antagonist family
DKE43_RS07435	COG1393	Belongs to the ArsC family
DKE43_RS07445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE43_RS07460	COG0011	TIGRFAM Protein of
DKE43_RS07465	COG2814	Major facilitator Superfamily
DKE43_RS07475	COG2866	Carboxypeptidase
DKE43_RS07480	COG1368	sulfuric ester hydrolase activity
DKE43_RS07485	COG1940	carbohydrate kinase activity
DKE43_RS07490	COG4483	Protein conserved in bacteria
DKE43_RS07495	COG0457	Tetratricopeptide repeat
DKE43_RS07495	COG0705	Rhomboid family
DKE43_RS07500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DKE43_RS07505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DKE43_RS07515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DKE43_RS07520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DKE43_RS07525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DKE43_RS07530	COG0581	inorganic phosphate transmembrane transporter activity
DKE43_RS07535	COG0573	inorganic phosphate transmembrane transporter activity
DKE43_RS07540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DKE43_RS07545	COG0768	penicillin binding
DKE43_RS07550	COG0477	Major facilitator Superfamily
DKE43_RS07555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKE43_RS07560	COG2839	Protein conserved in bacteria
DKE43_RS07565	COG5521	maltodextrose utilization protein MalA
DKE43_RS07570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKE43_RS07575	COG1388	LysM domain
DKE43_RS07580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DKE43_RS07585	COG4709	membrane
DKE43_RS07590	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DKE43_RS07595	COG1940	carbohydrate kinase activity
DKE43_RS07600	COG0735	belongs to the Fur family
DKE43_RS07605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKE43_RS07610	COG1121	(ABC) transporter
DKE43_RS07615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DKE43_RS07625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DKE43_RS07630	COG0513	Belongs to the DEAD box helicase family
DKE43_RS07640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DKE43_RS07645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DKE43_RS07650	COG2384	SAM-dependent methyltransferase
DKE43_RS07655	COG2010	Cytochrome c
DKE43_RS07660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DKE43_RS07665	COG0358	DNA primase activity
DKE43_RS07670	COG1671	Belongs to the UPF0178 family
DKE43_RS07675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DKE43_RS07680	COG0517	IMP dehydrogenase activity
DKE43_RS07685	COG0751	glycine-tRNA ligase activity
DKE43_RS07690	COG0752	glycyl-tRNA synthetase alpha subunit
DKE43_RS07695	COG1381	Involved in DNA repair and RecF pathway recombination
DKE43_RS07705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DKE43_RS07710	COG0295	cytidine deaminase activity
DKE43_RS07715	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DKE43_RS07720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DKE43_RS07725	COG1480	7TM receptor with intracellular HD hydrolase
DKE43_RS07730	COG1702	phosphate starvation-inducible protein PhoH
DKE43_RS07735	COG0561	phosphatase activity
DKE43_RS07750	COG4864	UPF0365 protein
DKE43_RS07755	COG1030	water channel activity
DKE43_RS07760	COG1610	YqeY-like protein
DKE43_RS07770	COG1283	sodium-dependent phosphate transmembrane transporter activity
DKE43_RS07775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DKE43_RS07780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DKE43_RS07785	COG2264	protein methyltransferase activity
DKE43_RS07790	COG0484	heat shock protein binding
DKE43_RS07795	COG0443	Heat shock 70 kDa protein
DKE43_RS07800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DKE43_RS07805	COG1420	regulation of RNA biosynthetic process
DKE43_RS07810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKE43_RS07815	COG0481	GTPase activity
DKE43_RS07825	COG0860	N-Acetylmuramoyl-L-alanine amidase
DKE43_RS07830	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DKE43_RS07835	COG0268	Binds directly to 16S ribosomal RNA
DKE43_RS07840	COG1466	dna polymerase III delta subunit
DKE43_RS07850	COG0658	competence protein
DKE43_RS07850	COG2333	competence protein COMEC
DKE43_RS07855	COG2131	deaminase
DKE43_RS07860	COG1555	photosystem II stabilization
DKE43_RS07865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DKE43_RS07870	COG2226	methyltransferase
DKE43_RS07875	COG0799	negative regulation of ribosome biogenesis
DKE43_RS07880	COG1713	HD superfamily hydrolase involved in NAD metabolism
DKE43_RS07885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DKE43_RS07890	COG1534	Rna-binding protein
DKE43_RS07895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DKE43_RS07900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DKE43_RS07905	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DKE43_RS07915	COG2755	lipolytic protein G-D-S-L family
DKE43_RS07925	COG0457	Tetratricopeptide repeat
DKE43_RS07940	COG4221	oxidoreductase activity
DKE43_RS07945	COG0300	oxidoreductase activity
DKE43_RS07950	COG1902	pentaerythritol trinitrate reductase activity
DKE43_RS07955	COG0596	Alpha beta hydrolase
DKE43_RS07955	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE43_RS07960	COG1309	transcriptional regulator
DKE43_RS07970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DKE43_RS07985	COG0726	polysaccharide deacetylase
DKE43_RS08020	COG1122	ATPase activity
DKE43_RS08040	COG2160	L-arabinose isomerase activity
DKE43_RS08055	COG1609	Transcriptional regulator
DKE43_RS08065	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DKE43_RS08070	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DKE43_RS08075	COG1733	regulation of RNA biosynthetic process
DKE43_RS08080	COG0657	acetylesterase activity
DKE43_RS08100	COG3209	COG3209 Rhs family protein
DKE43_RS08105	COG2602	Beta-lactamase
DKE43_RS08110	COG1960	acyl-CoA dehydrogenase activity
DKE43_RS08115	COG1126	abc transporter atp-binding protein
DKE43_RS08120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE43_RS08125	COG0765	amino acid transport
DKE43_RS08135	COG3546	catalase activity
DKE43_RS08140	COG1063	alcohol dehydrogenase
DKE43_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS08155	COG0842	Transport permease protein
DKE43_RS08160	COG1511	domain protein
DKE43_RS08160	COG0842	Transport permease protein
DKE43_RS08165	COG1131	(ABC) transporter
DKE43_RS08170	COG1063	alcohol dehydrogenase
DKE43_RS08175	COG2226	methyltransferase
DKE43_RS08195	COG0626	cystathionine gamma-synthase activity
DKE43_RS08200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DKE43_RS08205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DKE43_RS08210	COG2226	methyltransferase
DKE43_RS08225	COG0768	penicillin binding
DKE43_RS08230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DKE43_RS08235	COG0572	uridine kinase
DKE43_RS08240	COG0826	peptidase U32
DKE43_RS08245	COG0826	peptidase U32
DKE43_RS08250	COG4122	O-methyltransferase activity
DKE43_RS08255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DKE43_RS08260	COG0183	Belongs to the thiolase family
DKE43_RS08265	COG0318	PFAM AMP-dependent synthetase and ligase
DKE43_RS08270	COG1268	BioY protein
DKE43_RS08275	COG3906	Belongs to the UPF0473 family
DKE43_RS08280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DKE43_RS08285	COG4472	Bacterial protein of unknown function (DUF965)
DKE43_RS08290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DKE43_RS08295	COG0628	permease
DKE43_RS08300	COG1126	abc transporter atp-binding protein
DKE43_RS08305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE43_RS08310	COG0765	amino acid transport
DKE43_RS08315	COG0765	amino acid transport
DKE43_RS08330	COG3881	PFAM PRC-barrel domain
DKE43_RS08335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKE43_RS08340	COG0457	Tetratricopeptide repeat
DKE43_RS08345	COG0482	sulfurtransferase activity
DKE43_RS08350	COG1104	cysteine desulfurase activity
DKE43_RS08355	COG1959	2 iron, 2 sulfur cluster binding
DKE43_RS08360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DKE43_RS08365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DKE43_RS08380	COG0124	histidyl-tRNA synthetase
DKE43_RS08385	COG0860	N-Acetylmuramoyl-L-alanine amidase
DKE43_RS08385	COG3103	Sh3 type 3 domain protein
DKE43_RS08385	COG4991	sh3 domain protein
DKE43_RS08390	COG1490	D-aminoacyl-tRNA deacylase activity
DKE43_RS08395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DKE43_RS08400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DKE43_RS08405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DKE43_RS08405	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DKE43_RS08410	COG5416	Lipopolysaccharide assembly protein A domain
DKE43_RS08415	COG0490	domain, Protein
DKE43_RS08420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE43_RS08420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKE43_RS08430	COG2244	polysaccharide biosynthetic process
DKE43_RS08435	COG2323	membrane
DKE43_RS08445	COG1862	Preprotein translocase
DKE43_RS08450	COG0343	queuine tRNA-ribosyltransferase activity
DKE43_RS08455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DKE43_RS08465	COG2255	four-way junction helicase activity
DKE43_RS08470	COG0632	four-way junction helicase activity
DKE43_RS08480	COG2112	serine threonine protein kinase
DKE43_RS08490	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DKE43_RS08505	COG1388	LysM domain
DKE43_RS08505	COG1388	LysM domain
DKE43_RS08510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DKE43_RS08515	COG0157	Belongs to the NadC ModD family
DKE43_RS08520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DKE43_RS08525	COG1104	cysteine desulfurase activity
DKE43_RS08530	COG1827	regulation of RNA biosynthetic process
DKE43_RS08535	COG0077	Prephenate dehydratase
DKE43_RS08540	COG4492	Belongs to the UPF0735 family
DKE43_RS08545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DKE43_RS08550	COG3290	protein histidine kinase activity
DKE43_RS08555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DKE43_RS08560	COG2868	ribosomal protein
DKE43_RS08565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DKE43_RS08570	COG1994	Peptidase M50
DKE43_RS08575	COG0739	heme binding
DKE43_RS08580	COG2894	cell division
DKE43_RS08585	COG0850	regulation of cytokinetic process
DKE43_RS08590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DKE43_RS08600	COG1077	Cell shape determining protein MreB Mrl
DKE43_RS08605	COG2003	Belongs to the UPF0758 family
DKE43_RS08610	COG0424	maF-like protein
DKE43_RS08625	COG0285	dihydrofolate synthase activity
DKE43_RS08630	COG0525	valine-tRNA ligase activity
DKE43_RS08640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE43_RS08645	COG1388	LysM domain
DKE43_RS08650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DKE43_RS08655	COG0113	porphobilinogen synthase activity
DKE43_RS08660	COG1587	Uroporphyrinogen-III synthase
DKE43_RS08665	COG0181	hydroxymethylbilane synthase activity
DKE43_RS08670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DKE43_RS08675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DKE43_RS08685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DKE43_RS08690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DKE43_RS08695	COG0470	DNA polymerase III
DKE43_RS08695	COG1067	ATP-dependent peptidase activity
DKE43_RS08700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DKE43_RS08705	COG0544	peptidyl-prolyl cis-trans isomerase activity
DKE43_RS08710	COG0457	Tetratricopeptide repeat
DKE43_RS08710	COG1477	protein flavinylation
DKE43_RS08715	COG0066	3-isopropylmalate dehydratase activity
DKE43_RS08720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DKE43_RS08725	COG0473	3-isopropylmalate dehydrogenase activity
DKE43_RS08730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DKE43_RS08735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DKE43_RS08740	COG0440	acetolactate synthase activity
DKE43_RS08745	COG0028	Belongs to the TPP enzyme family
DKE43_RS08750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DKE43_RS08755	COG2706	6-phosphogluconolactonase activity
DKE43_RS08760	COG3339	Conserved Protein
DKE43_RS08765	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DKE43_RS08770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKE43_RS08775	COG1696	Membrane protein involved in D-alanine export
DKE43_RS08780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DKE43_RS08825	COG0622	Phosphoesterase
DKE43_RS08830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DKE43_RS08835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DKE43_RS08840	COG5401	PFAM Sporulation and spore germination
DKE43_RS08845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKE43_RS08850	COG1846	Transcriptional regulator
DKE43_RS08855	COG2197	response regulator
DKE43_RS08860	COG2851	Citrate transporter
DKE43_RS08865	COG0583	DNA-binding transcription factor activity
DKE43_RS08870	COG2828	Protein conserved in bacteria
DKE43_RS08880	COG0824	Thioesterase
DKE43_RS08885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKE43_RS08890	COG1053	succinate dehydrogenase
DKE43_RS08895	COG2009	succinate dehydrogenase
DKE43_RS08900	COG1719	4-vinyl reductase, 4VR
DKE43_RS08905	COG0527	aspartate kinase activity
DKE43_RS08910	COG0322	excinuclease ABC activity
DKE43_RS08915	COG3118	belongs to the thioredoxin family
DKE43_RS08920	COG3534	alpha-L-arabinofuranosidase
DKE43_RS08925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DKE43_RS08930	COG2086	electron transfer activity
DKE43_RS08935	COG1024	Enoyl-CoA hydratase
DKE43_RS08940	COG1309	transcriptional regulator
DKE43_RS08945	COG0318	PFAM AMP-dependent synthetase and ligase
DKE43_RS08955	COG3766	membrane
DKE43_RS08960	COG1193	negative regulation of DNA recombination
DKE43_RS08965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DKE43_RS08965	COG1796	DNA polymerase
DKE43_RS08970	COG1286	toxin biosynthetic process
DKE43_RS08975	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DKE43_RS08980	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DKE43_RS08985	COG0072	phenylalanine-tRNA ligase activity
DKE43_RS08985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE43_RS08990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DKE43_RS08995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE43_RS09005	COG1966	Carbon starvation protein
DKE43_RS09010	COG1363	Peptidase, m42
DKE43_RS09020	COG3326	Membrane
DKE43_RS09025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DKE43_RS09030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKE43_RS09035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DKE43_RS09040	COG1346	cytolysis
DKE43_RS09050	COG3279	Response regulator of the LytR AlgR family
DKE43_RS09055	COG3275	phosphorelay sensor kinase activity
DKE43_RS09060	COG1011	Hydrolase
DKE43_RS09070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DKE43_RS09085	COG0398	Pfam SNARE associated Golgi protein
DKE43_RS09090	COG1484	DNA-dependent DNA replication
DKE43_RS09095	COG3611	Membrane attachment protein
DKE43_RS09100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DKE43_RS09110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DKE43_RS09115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DKE43_RS09120	COG0237	dephospho-CoA kinase activity
DKE43_RS09125	COG1971	Probably functions as a manganese efflux pump
DKE43_RS09130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DKE43_RS09135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DKE43_RS09135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DKE43_RS09145	COG5002	protein histidine kinase activity
DKE43_RS09150	COG0745	RESPONSE REGULATOR receiver
DKE43_RS09155	COG0039	L-malate dehydrogenase activity
DKE43_RS09160	COG0538	isocitrate dehydrogenase activity
DKE43_RS09165	COG0372	Belongs to the citrate synthase family
DKE43_RS09170	COG2707	UPF0756 membrane protein
DKE43_RS09175	COG0628	permease
DKE43_RS09180	COG3030	protein affecting phage T7 exclusion by the F plasmid
DKE43_RS09190	COG0205	6-phosphofructokinase activity
DKE43_RS09195	COG0825	malonyl-CoA metabolic process
DKE43_RS09200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DKE43_RS09205	COG0281	malic enzyme
DKE43_RS09210	COG0587	DNA-directed DNA polymerase activity
DKE43_RS09230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DKE43_RS09240	COG4109	DRTGG domain
DKE43_RS09245	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DKE43_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS09255	COG0165	Argininosuccinate lyase
DKE43_RS09260	COG0137	argininosuccinate synthase activity
DKE43_RS09265	COG0521	Mo-molybdopterin cofactor biosynthetic process
DKE43_RS09270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DKE43_RS09275	COG0827	DNA restriction-modification system
DKE43_RS09280	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DKE43_RS09285	COG3874	Sporulation protein YtfJ
DKE43_RS09295	COG1714	RDD family
DKE43_RS09300	COG0616	signal peptide processing
DKE43_RS09305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKE43_RS09315	COG3239	Fatty acid desaturase
DKE43_RS09320	COG4585	Histidine kinase
DKE43_RS09325	COG2197	response regulator
DKE43_RS09330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKE43_RS09335	COG0745	RESPONSE REGULATOR receiver
DKE43_RS09340	COG2205	protein histidine kinase activity
DKE43_RS09345	COG0772	Belongs to the SEDS family
DKE43_RS09350	COG1695	Transcriptional regulator
DKE43_RS09355	COG1136	(ABC) transporter
DKE43_RS09360	COG0577	efflux transmembrane transporter activity
DKE43_RS09365	COG0402	S-adenosylhomocysteine deaminase activity
DKE43_RS09370	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE43_RS09390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE43_RS09400	COG0301	tRNA thio-modification
DKE43_RS09405	COG1104	cysteine desulfurase activity
DKE43_RS09410	COG1114	Component of the transport system for branched-chain amino acids
DKE43_RS09415	COG1114	Component of the transport system for branched-chain amino acids
DKE43_RS09420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DKE43_RS09425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DKE43_RS09430	COG1309	transcriptional regulator
DKE43_RS09435	COG1956	GAF domain-containing protein
DKE43_RS09440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DKE43_RS09450	COG1335	isochorismatase
DKE43_RS09460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DKE43_RS09465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DKE43_RS09470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKE43_RS09475	COG0454	-acetyltransferase
DKE43_RS09480	COG0517	IMP dehydrogenase activity
DKE43_RS09485	COG0123	including yeast histone deacetylase and acetoin utilization protein
DKE43_RS09490	COG1609	Transcriptional regulator
DKE43_RS09495	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DKE43_RS09495	COG1605	Chorismate mutase
DKE43_RS09500	COG3118	belongs to the thioredoxin family
DKE43_RS09505	COG4980	gas vesicle protein
DKE43_RS09510	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DKE43_RS09515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKE43_RS09520	COG1674	ftsk spoiiie
DKE43_RS09525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE43_RS09530	COG4848	Belongs to the UPF0354 family
DKE43_RS09535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKE43_RS09550	COG1363	Peptidase, m42
DKE43_RS09555	COG5584	Small secreted protein
DKE43_RS09560	COG0281	malic enzyme
DKE43_RS09565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE43_RS09570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKE43_RS09580	COG0510	thiamine kinase activity
DKE43_RS09585	COG1597	lipid kinase activity
DKE43_RS09595	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DKE43_RS09600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DKE43_RS09605	COG3340	Belongs to the peptidase S51 family
DKE43_RS09610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKE43_RS09615	COG2252	PERMEase
DKE43_RS09620	COG1349	DNA-binding transcription factor activity
DKE43_RS09625	COG1187	pseudouridine synthase activity
DKE43_RS09630	COG2244	polysaccharide biosynthetic process
DKE43_RS09635	COG2081	HI0933 family
DKE43_RS09645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DKE43_RS09660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DKE43_RS09665	COG5578	integral membrane protein
DKE43_RS09670	COG0673	inositol 2-dehydrogenase activity
DKE43_RS09675	COG1653	transport
DKE43_RS09680	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DKE43_RS09685	COG4209	transmembrane transport
DKE43_RS09690	COG2207	Transcriptional regulator
DKE43_RS09695	COG1733	regulation of RNA biosynthetic process
DKE43_RS09700	COG2814	Major facilitator Superfamily
DKE43_RS09705	COG0656	L-ascorbic acid biosynthetic process
DKE43_RS09710	COG1653	transport
DKE43_RS09715	COG0395	ABC-type sugar transport system, permease component
DKE43_RS09720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DKE43_RS09725	COG1073	alpha beta
DKE43_RS09730	COG0495	leucyl-tRNA aminoacylation
DKE43_RS09745	COG1366	Belongs to the anti-sigma-factor antagonist family
DKE43_RS09745	COG2202	Pas domain
DKE43_RS09750	COG2433	Pfam Transposase IS66
DKE43_RS09755	COG0577	efflux transmembrane transporter activity
DKE43_RS09760	COG1136	(ABC) transporter
DKE43_RS09770	COG1131	(ABC) transporter
DKE43_RS09775	COG1725	Transcriptional regulator
DKE43_RS09790	COG1242	4 iron, 4 sulfur cluster binding
DKE43_RS09795	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DKE43_RS09805	COG2267	carboxylic ester hydrolase activity
DKE43_RS09810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKE43_RS09815	COG0367	asparagine synthase
DKE43_RS09820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DKE43_RS09825	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DKE43_RS09835	COG1506	peptidase
DKE43_RS09840	COG1233	COG1233 Phytoene dehydrogenase and related
DKE43_RS09860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DKE43_RS09865	COG1116	anion transmembrane transporter activity
DKE43_RS09870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKE43_RS09875	COG0494	nUDIX hydrolase
DKE43_RS09880	COG2310	stress, protein
DKE43_RS09900	COG4824	toxin secretion phage lysis holin
DKE43_RS09910	COG0783	Belongs to the Dps family
DKE43_RS09925	COG1854	S-ribosylhomocysteine lyase activity
DKE43_RS09930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DKE43_RS09935	COG0288	reversible hydration of carbon dioxide
DKE43_RS09940	COG0803	Belongs to the bacterial solute-binding protein 9 family
DKE43_RS09940	COG3443	Belongs to the bacterial solute-binding protein 9 family
DKE43_RS09945	COG0254	rRNA binding
DKE43_RS09955	COG1271	oxidase subunit
DKE43_RS09960	COG1294	oxidase, subunit
DKE43_RS09975	COG4948	Mandelate Racemase Muconate Lactonizing
DKE43_RS09980	COG0318	PFAM AMP-dependent synthetase and ligase
DKE43_RS09985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DKE43_RS09990	COG0596	Alpha beta hydrolase
DKE43_RS09995	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DKE43_RS10000	COG1169	isochorismate synthase
DKE43_RS10005	COG1575	Belongs to the MenA family. Type 1 subfamily
DKE43_RS10010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DKE43_RS10140	COG3859	Proton-coupled thiamine transporter YuaJ
DKE43_RS10150	COG1247	-acetyltransferase
DKE43_RS10155	COG3339	Conserved Protein
DKE43_RS10160	COG0772	Belongs to the SEDS family
DKE43_RS10165	COG0772	Belongs to the SEDS family
DKE43_RS10175	COG2268	Band 7 protein
DKE43_RS10180	COG1585	Membrane protein implicated in regulation of membrane protease activity
DKE43_RS10185	COG2318	DinB family
DKE43_RS10190	COG1454	alcohol dehydrogenase
DKE43_RS10195	COG1012	belongs to the aldehyde dehydrogenase family
DKE43_RS10200	COG1510	regulation of RNA biosynthetic process
DKE43_RS10215	COG5632	N-Acetylmuramoyl-L-alanine amidase
DKE43_RS10215	COG3409	Peptidoglycan-binding domain 1 protein
DKE43_RS10265	COG3778	Protein conserved in bacteria
DKE43_RS10270	COG3299	homolog of phage Mu protein gp47
DKE43_RS10275	COG3628	GPW Gp25 family protein
DKE43_RS10285	COG4193	domain, Protein
DKE43_RS10290	COG1652	LysM domain
DKE43_RS10295	COG5280	Phage tail tape measure protein TP901
DKE43_RS10295	COG3953	SLT domain
DKE43_RS10295	COG5280	Phage tail tape measure protein TP901
DKE43_RS10295	COG3953	SLT domain
DKE43_RS10350	COG4653	Phage capsid family
DKE43_RS10355	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DKE43_RS10360	COG5518	Phage portal protein
DKE43_RS10365	COG1783	phage Terminase large subunit
DKE43_RS10370	COG5484	DNA packaging
DKE43_RS10375	COG1595	DNA-templated transcription, initiation
DKE43_RS10385	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
DKE43_RS10400	COG1396	sequence-specific DNA binding
DKE43_RS10410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DKE43_RS10425	COG0628	permease
DKE43_RS10435	COG0673	inositol 2-dehydrogenase activity
DKE43_RS10440	COG0693	protein deglycase activity
DKE43_RS10445	COG0840	transmembrane signaling receptor activity
DKE43_RS10450	COG0840	transmembrane signaling receptor activity
DKE43_RS10455	COG0840	transmembrane signaling receptor activity
DKE43_RS10460	COG0840	transmembrane signaling receptor activity
DKE43_RS10475	COG2070	2-Nitropropane dioxygenase
DKE43_RS10480	COG0432	Pfam Uncharacterised protein family UPF0047
DKE43_RS10485	COG1253	flavin adenine dinucleotide binding
DKE43_RS10490	COG2738	Putative neutral zinc metallopeptidase
DKE43_RS10500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DKE43_RS10515	COG0166	Belongs to the GPI family
DKE43_RS10520	COG1979	alcohol dehydrogenase
DKE43_RS10525	COG1979	alcohol dehydrogenase
DKE43_RS10530	COG2155	Conserved Protein
DKE43_RS10535	COG1098	S1 RNA binding domain
DKE43_RS10540	COG0436	Aminotransferase
DKE43_RS10545	COG1522	sequence-specific DNA binding
DKE43_RS10550	COG2267	carboxylic ester hydrolase activity
DKE43_RS10560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DKE43_RS10565	COG2205	protein histidine kinase activity
DKE43_RS10580	COG5018	Exonuclease
DKE43_RS10585	COG2814	Major facilitator Superfamily
DKE43_RS10590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DKE43_RS10595	COG3011	Protein conserved in bacteria
DKE43_RS10610	COG3290	protein histidine kinase activity
DKE43_RS10615	COG4565	transcriptional regulatory protein
DKE43_RS10620	COG1744	ABC transporter substrate-binding protein PnrA-like
DKE43_RS10625	COG3845	ABC transporter
DKE43_RS10630	COG4603	Belongs to the binding-protein-dependent transport system permease family
DKE43_RS10635	COG1079	Belongs to the binding-protein-dependent transport system permease family
DKE43_RS10640	COG3493	citrate carrier protein
DKE43_RS10650	COG2111	Na H antiporter
DKE43_RS10650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DKE43_RS10655	COG2111	Na H antiporter
DKE43_RS10660	COG1006	Multisubunit Na H antiporter MnhC subunit
DKE43_RS10665	COG0651	ATP synthesis coupled electron transport
DKE43_RS10670	COG1863	multisubunit Na H antiporter MnhE subunit
DKE43_RS10675	COG2212	antiporter activity
DKE43_RS10680	COG1320	monovalent cation:proton antiporter activity
DKE43_RS10685	COG2050	protein possibly involved in aromatic compounds catabolism
DKE43_RS10690	COG2197	response regulator
DKE43_RS10695	COG4585	Histidine kinase
DKE43_RS10705	COG0142	geranyltranstransferase activity
DKE43_RS10720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DKE43_RS10725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DKE43_RS10730	COG1335	isochorismatase
DKE43_RS10735	COG5506	Protein of unknown function (DUF1694)
DKE43_RS10755	COG0628	permease
DKE43_RS10770	COG1418	mRNA catabolic process
DKE43_RS10775	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS10785	COG1511	domain protein
DKE43_RS10790	COG1674	ftsk spoiiie
DKE43_RS10790	COG0433	COG0433 Predicted ATPase
DKE43_RS10795	COG4499	WXG100 protein secretion system (Wss), protein YukC
DKE43_RS10800	COG5417	Belongs to the EsaB family
DKE43_RS10805	COG4842	Belongs to the WXG100 family
DKE43_RS10810	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DKE43_RS10810	COG2508	Transcriptional regulator
DKE43_RS10815	COG0686	Belongs to the AlaDH PNT family
DKE43_RS10820	COG1268	BioY protein
DKE43_RS10825	COG4326	sporulation control protein
DKE43_RS10830	COG2056	Na+-H+ antiporter family
DKE43_RS10835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DKE43_RS10840	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DKE43_RS10845	COG3584	3D domain protein
DKE43_RS10855	COG1252	NADH dehydrogenase
DKE43_RS10860	COG0492	ferredoxin-NADP+ reductase activity
DKE43_RS10875	COG0316	Belongs to the HesB IscA family
DKE43_RS10880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DKE43_RS10885	COG4844	belongs to the
DKE43_RS10890	COG1252	NADH dehydrogenase
DKE43_RS10900	COG4837	Protein of unknown function (DUF1462)
DKE43_RS10905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DKE43_RS10915	COG4946	Tricorn protease homolog
DKE43_RS10915	COG1506	peptidase
DKE43_RS10915	COG0823	Involved in the tonB-independent uptake of proteins
DKE43_RS10920	COG0083	homoserine kinase activity
DKE43_RS10925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DKE43_RS10930	COG0460	homoserine dehydrogenase
DKE43_RS10935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DKE43_RS10940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE43_RS10945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DKE43_RS10950	COG0647	UMP catabolic process
DKE43_RS10955	COG2445	Protein of unknown function DUF86
DKE43_RS10960	COG4470	Protein conserved in bacteria
DKE43_RS10970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKE43_RS10975	COG0739	heme binding
DKE43_RS10985	COG3377	Domain of unknown function (DUF1805)
DKE43_RS10990	COG0737	Belongs to the 5'-nucleotidase family
DKE43_RS10995	COG1801	Protein of unknown function DUF72
DKE43_RS11000	COG2508	Transcriptional regulator
DKE43_RS11010	COG2814	Major facilitator Superfamily
DKE43_RS11015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DKE43_RS11030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE43_RS11035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE43_RS11040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKE43_RS11055	COG5002	protein histidine kinase activity
DKE43_RS11055	COG0642	Histidine kinase
DKE43_RS11060	COG0745	RESPONSE REGULATOR receiver
DKE43_RS11065	COG2311	Membrane
DKE43_RS11075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DKE43_RS11080	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DKE43_RS11105	COG0719	Fe-S assembly protein
DKE43_RS11110	COG0822	iron-sulfur transferase activity
DKE43_RS11115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DKE43_RS11120	COG0719	Fe-S assembly protein
DKE43_RS11125	COG0396	ATPase activity
DKE43_RS11130	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKE43_RS11135	COG1464	Belongs to the NlpA lipoprotein family
DKE43_RS11140	COG2011	ABC-type metal ion transport system permease component
DKE43_RS11145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKE43_RS11155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKE43_RS11160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DKE43_RS11170	COG0509	glycine decarboxylation via glycine cleavage system
DKE43_RS11175	COG1393	Belongs to the ArsC family
DKE43_RS11180	COG1960	acyl-CoA dehydrogenase activity
DKE43_RS11185	COG0183	Belongs to the thiolase family
DKE43_RS11190	COG1250	3-hydroxyacyl-CoA dehydrogenase
DKE43_RS11190	COG1024	Enoyl-CoA hydratase
DKE43_RS11205	COG5577	PFAM Coat F domain
DKE43_RS11225	COG1120	ATPase activity
DKE43_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS11240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DKE43_RS11245	COG0745	RESPONSE REGULATOR receiver
DKE43_RS11250	COG2205	protein histidine kinase activity
DKE43_RS11250	COG2770	Histidine kinase
DKE43_RS11255	COG1309	transcriptional regulator
DKE43_RS11260	COG0114	fumarate hydratase activity
DKE43_RS11270	COG0697	spore germination
DKE43_RS11275	COG0814	amino acid
DKE43_RS11290	COG2197	response regulator
DKE43_RS11295	COG4585	Histidine kinase
DKE43_RS11300	COG4758	membrane
DKE43_RS11310	COG1842	Phage shock protein A
DKE43_RS11315	COG4758	membrane
DKE43_RS11320	COG2096	Adenosyltransferase
DKE43_RS11325	COG1120	ATPase activity
DKE43_RS11330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE43_RS11335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKE43_RS11345	COG2721	sulfolactate sulfo-lyase activity
DKE43_RS11350	COG0246	Mannitol dehydrogenase
DKE43_RS11355	COG1609	Transcriptional regulator
DKE43_RS11360	COG1904	glucuronate isomerase
DKE43_RS11365	COG2205	protein histidine kinase activity
DKE43_RS11370	COG0745	RESPONSE REGULATOR receiver
DKE43_RS11375	COG1120	ATPase activity
DKE43_RS11380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE43_RS11385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE43_RS11390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKE43_RS11395	COG0531	amino acid
DKE43_RS11415	COG1988	membrane-bound metal-dependent
DKE43_RS11420	COG1368	sulfuric ester hydrolase activity
DKE43_RS11425	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKE43_RS11430	COG4149	molybdate abc transporter
DKE43_RS11435	COG0656	L-ascorbic acid biosynthetic process
DKE43_RS11440	COG1940	carbohydrate kinase activity
DKE43_RS11445	COG0025	NhaP-type Na H and K H
DKE43_RS11455	COG2860	membrane
DKE43_RS11460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DKE43_RS11465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DKE43_RS11470	COG2217	Heavy metal translocating P-type atpase
DKE43_RS11475	COG1121	(ABC) transporter
DKE43_RS11480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKE43_RS11485	COG0803	Belongs to the bacterial solute-binding protein 9 family
DKE43_RS11495	COG3226	Transcriptional regulator
DKE43_RS11500	COG0784	Response regulator, receiver
DKE43_RS11505	COG4191	Histidine kinase
DKE43_RS11510	COG1027	Aspartate ammonia-lyase
DKE43_RS11520	COG2217	Heavy metal translocating P-type atpase
DKE43_RS11525	COG2608	mercury ion transmembrane transporter activity
DKE43_RS11530	COG1937	Protein conserved in bacteria
DKE43_RS11550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKE43_RS11565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DKE43_RS11570	COG0557	exoribonuclease II activity
DKE43_RS11575	COG1647	Serine aminopeptidase, S33
DKE43_RS11580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DKE43_RS11585	COG2002	toxin-antitoxin pair type II binding
DKE43_RS11590	COG1476	TRANSCRIPTIONal
DKE43_RS11595	COG1396	sequence-specific DNA binding
DKE43_RS11600	COG1396	sequence-specific DNA binding
DKE43_RS11605	COG1733	regulation of RNA biosynthetic process
DKE43_RS11610	COG1174	glycine betaine transport
DKE43_RS11615	COG1732	Glycine betaine
DKE43_RS11620	COG1174	glycine betaine transport
DKE43_RS11625	COG0517	IMP dehydrogenase activity
DKE43_RS11625	COG1125	glycine betaine transport
DKE43_RS11630	COG1510	regulation of RNA biosynthetic process
DKE43_RS11635	COG2095	MarC family integral membrane protein
DKE43_RS11645	COG0456	acetyltransferase
DKE43_RS11665	COG1131	(ABC) transporter
DKE43_RS11675	COG0148	phosphopyruvate hydratase activity
DKE43_RS11680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DKE43_RS11685	COG0149	triose-phosphate isomerase activity
DKE43_RS11690	COG0126	phosphoglycerate kinase activity
DKE43_RS11695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DKE43_RS11700	COG2390	Transcriptional regulator
DKE43_RS11705	COG0833	amino acid
DKE43_RS11710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKE43_RS11715	COG3829	transcription factor binding
DKE43_RS11720	COG2186	Transcriptional regulator
DKE43_RS11725	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DKE43_RS11735	COG0534	Mate efflux family protein
DKE43_RS11740	COG4608	Belongs to the ABC transporter superfamily
DKE43_RS11745	COG0444	Belongs to the ABC transporter superfamily
DKE43_RS11750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DKE43_RS11755	COG0601	transmembrane transport
DKE43_RS11760	COG0747	negative chemotaxis
DKE43_RS11765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DKE43_RS11770	COG0110	maltose O-acetyltransferase activity
DKE43_RS11775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DKE43_RS11780	COG2244	polysaccharide biosynthetic process
DKE43_RS11785	COG5039	Polysaccharide pyruvyl transferase
DKE43_RS11790	COG1216	Glycosyl transferase, family 2
DKE43_RS11800	COG0438	transferase activity, transferring glycosyl groups
DKE43_RS11805	COG1215	transferase activity, transferring glycosyl groups
DKE43_RS11810	COG0438	transferase activity, transferring glycosyl groups
DKE43_RS11815	COG1086	Polysaccharide biosynthesis protein
DKE43_RS11820	COG0489	protein tyrosine kinase activity
DKE43_RS11825	COG3944	biosynthesis protein
DKE43_RS11830	COG1396	sequence-specific DNA binding
DKE43_RS11840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKE43_RS11845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE43_RS11850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKE43_RS11855	COG0726	polysaccharide deacetylase
DKE43_RS11860	COG0488	(ABC) transporter
DKE43_RS11865	COG1124	(ABC) transporter
DKE43_RS11880	COG0601	transmembrane transport
DKE43_RS11885	COG0747	negative chemotaxis
DKE43_RS11890	COG1819	glycosyl
DKE43_RS11895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKE43_RS11905	COG0740	serine-type endopeptidase activity
DKE43_RS11910	COG1611	Belongs to the LOG family
DKE43_RS11915	COG1694	Mazg nucleotide pyrophosphohydrolase
DKE43_RS11920	COG0659	secondary active sulfate transmembrane transporter activity
DKE43_RS11925	COG0288	reversible hydration of carbon dioxide
DKE43_RS11930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DKE43_RS11940	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DKE43_RS11945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS11950	COG1481	regulation of sporulation
DKE43_RS11955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DKE43_RS11960	COG1660	Displays ATPase and GTPase activities
DKE43_RS11965	COG1051	belongs to the nudix hydrolase family
DKE43_RS11970	COG0492	ferredoxin-NADP+ reductase activity
DKE43_RS11975	COG3883	PFAM NLP P60 protein
DKE43_RS11975	COG0791	NLP P60 protein
DKE43_RS11980	COG0457	Tetratricopeptide repeat
DKE43_RS11985	COG0140	phosphoribosyl-ATP diphosphatase activity
DKE43_RS11985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DKE43_RS11990	COG0107	imidazoleglycerol-phosphate synthase activity
DKE43_RS11995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DKE43_RS12000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKE43_RS12005	COG0131	Imidazoleglycerol-phosphate dehydratase
DKE43_RS12010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKE43_RS12015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKE43_RS12020	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DKE43_RS12025	COG4990	cell redox homeostasis
DKE43_RS12030	COG2910	NAD(P)H-binding
DKE43_RS12035	COG1959	2 iron, 2 sulfur cluster binding
DKE43_RS12040	COG0110	maltose O-acetyltransferase activity
DKE43_RS12045	COG0546	phosphoglycolate phosphatase activity
DKE43_RS12050	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DKE43_RS12060	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DKE43_RS12065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DKE43_RS12070	COG0363	glucosamine-6-phosphate deaminase activity
DKE43_RS12075	COG2188	Transcriptional regulator
DKE43_RS12080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DKE43_RS12085	COG1950	PFAM Membrane protein of
DKE43_RS12090	COG1983	PspC domain protein
DKE43_RS12095	COG3595	metallopeptidase activity
DKE43_RS12110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DKE43_RS12120	COG4897	Protein conserved in bacteria
DKE43_RS12125	COG0574	Belongs to the PEP-utilizing enzyme family
DKE43_RS12125	COG3848	Pyruvate phosphate dikinase
DKE43_RS12130	COG1309	transcriptional regulator
DKE43_RS12135	COG2814	Major facilitator Superfamily
DKE43_RS12145	COG0745	RESPONSE REGULATOR receiver
DKE43_RS12150	COG5002	protein histidine kinase activity
DKE43_RS12155	COG1113	amino acid transport
DKE43_RS12160	COG0778	Nitroreductase
DKE43_RS12165	COG1733	regulation of RNA biosynthetic process
DKE43_RS12170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DKE43_RS12180	COG3409	Peptidoglycan-binding domain 1 protein
DKE43_RS12180	COG0793	Belongs to the peptidase S41A family
DKE43_RS12185	COG0730	response to heat
DKE43_RS12190	COG0791	NLP P60 protein
DKE43_RS12190	COG3883	PFAM NLP P60 protein
DKE43_RS12195	COG2177	Part of the ABC transporter FtsEX involved in
DKE43_RS12200	COG2884	Cell division ATP-binding protein ftsE
DKE43_RS12205	COG2010	Cytochrome c
DKE43_RS12210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DKE43_RS12230	COG0653	protein targeting
DKE43_RS12235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DKE43_RS12240	COG0840	transmembrane signaling receptor activity
DKE43_RS12255	COG1516	flagellar protein fliS
DKE43_RS12260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DKE43_RS12265	COG1334	flagellar protein FlaG
DKE43_RS12270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DKE43_RS12275	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DKE43_RS12285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DKE43_RS12290	COG1256	bacterial-type flagellum assembly
DKE43_RS12290	COG4786	Flagellar basal body rod
DKE43_RS12295	COG3418	PFAM FlgN family protein
DKE43_RS12310	COG1040	competence protein
DKE43_RS12320	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DKE43_RS12325	COG1307	EDD domain protein, DegV family
DKE43_RS12330	COG2197	response regulator
DKE43_RS12335	COG4585	Histidine kinase
DKE43_RS12340	COG1739	Uncharacterized protein family UPF0029
DKE43_RS12345	COG1316	TRANSCRIPTIONal
DKE43_RS12350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DKE43_RS12355	COG0438	transferase activity, transferring glycosyl groups
DKE43_RS12360	COG1215	transferase activity, transferring glycosyl groups
DKE43_RS12365	COG3206	protein involved in exopolysaccharide biosynthesis
DKE43_RS12370	COG3307	-O-antigen
DKE43_RS12375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DKE43_RS12380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DKE43_RS12385	COG0297	glycogen (starch) synthase activity
DKE43_RS12385	COG0438	transferase activity, transferring glycosyl groups
DKE43_RS12390	COG2244	polysaccharide biosynthetic process
DKE43_RS12405	COG2247	cell wall binding repeat
DKE43_RS12405	COG0860	N-Acetylmuramoyl-L-alanine amidase
DKE43_RS12410	COG2247	cell wall binding repeat
DKE43_RS12410	COG2385	sporulation resulting in formation of a cellular spore
DKE43_RS12420	COG1316	TRANSCRIPTIONal
DKE43_RS12425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKE43_RS12430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DKE43_RS12435	COG1134	teichoic acid transport
DKE43_RS12440	COG1682	transport, permease protein
DKE43_RS12450	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DKE43_RS12460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DKE43_RS12465	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DKE43_RS12470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DKE43_RS12480	COG4193	domain, Protein
DKE43_RS12485	COG1482	cell wall glycoprotein biosynthetic process
DKE43_RS12495	COG1175	transmembrane transport
DKE43_RS12500	COG1653	transport
DKE43_RS12505	COG2197	response regulator
DKE43_RS12510	COG2972	Histidine kinase
DKE43_RS12520	COG0454	-acetyltransferase
DKE43_RS12525	COG0800	Aldolase
DKE43_RS12530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DKE43_RS12535	COG1609	Transcriptional regulator
DKE43_RS12540	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DKE43_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS12550	COG0697	spore germination
DKE43_RS12555	COG0814	amino acid
DKE43_RS12570	COG2814	Major facilitator Superfamily
DKE43_RS12575	COG1316	TRANSCRIPTIONal
DKE43_RS12585	COG0561	phosphatase activity
DKE43_RS12590	COG0791	NLP P60 protein
DKE43_RS12595	COG2843	Capsule synthesis protein
DKE43_RS12605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DKE43_RS12610	COG0697	spore germination
DKE43_RS12625	COG1609	Transcriptional regulator
DKE43_RS12630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DKE43_RS12635	COG1869	D-ribose catabolic process
DKE43_RS12640	COG1129	ABC transporter
DKE43_RS12645	COG1172	Belongs to the binding-protein-dependent transport system permease family
DKE43_RS12650	COG1879	ABC-type sugar transport system periplasmic component
DKE43_RS12655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKE43_RS12660	COG0583	DNA-binding transcription factor activity
DKE43_RS12665	COG0028	Belongs to the TPP enzyme family
DKE43_RS12670	COG3527	Alpha-acetolactate decarboxylase
DKE43_RS12675	COG1522	sequence-specific DNA binding
DKE43_RS12680	COG2059	Chromate
DKE43_RS12685	COG2059	Chromate
DKE43_RS12690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DKE43_RS12695	COG4715	Zinc finger, swim domain protein
DKE43_RS12700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DKE43_RS12705	COG2202	Pas domain
DKE43_RS12705	COG1366	Belongs to the anti-sigma-factor antagonist family
DKE43_RS12710	COG0561	phosphatase activity
DKE43_RS12725	COG1970	mechanosensitive ion channel activity
DKE43_RS12730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DKE43_RS12735	COG0457	Tetratricopeptide repeat
DKE43_RS12740	COG4786	Flagellar basal body rod
DKE43_RS12745	COG4786	Flagellar basal body rod
DKE43_RS12750	COG1077	Cell shape determining protein MreB Mrl
DKE43_RS12755	COG1609	Transcriptional regulator
DKE43_RS12760	COG1846	Transcriptional regulator
DKE43_RS12765	COG2814	Major facilitator Superfamily
DKE43_RS12770	COG0671	phosphoesterase, PA-phosphatase related
DKE43_RS12775	COG0477	Major facilitator Superfamily
DKE43_RS12780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE43_RS12785	COG0765	amino acid transport
DKE43_RS12790	COG1126	abc transporter atp-binding protein
DKE43_RS12800	COG0004	ammonium transporteR
DKE43_RS12805	COG0347	Belongs to the P(II) protein family
DKE43_RS12810	COG0739	heme binding
DKE43_RS12815	COG1247	-acetyltransferase
DKE43_RS12855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DKE43_RS12860	COG0523	cobalamin synthesis protein
DKE43_RS12865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DKE43_RS12870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKE43_RS12875	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKE43_RS12880	COG2223	nitrite transmembrane transporter activity
DKE43_RS12885	COG0243	molybdopterin cofactor binding
DKE43_RS12890	COG2304	oxidoreductase activity
DKE43_RS12895	COG2304	oxidoreductase activity
DKE43_RS12900	COG2385	sporulation resulting in formation of a cellular spore
DKE43_RS12905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DKE43_RS12915	COG4836	Membrane
DKE43_RS12925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DKE43_RS12930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKE43_RS12935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DKE43_RS12940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DKE43_RS12945	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DKE43_RS12950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DKE43_RS12955	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DKE43_RS12960	COG0356	it plays a direct role in the translocation of protons across the membrane
DKE43_RS12970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DKE43_RS12975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DKE43_RS12980	COG4475	Protein of unknown function (DUF436)
DKE43_RS12985	COG0698	ribose 5-phosphate isomerase
DKE43_RS12990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKE43_RS12995	COG1971	Probably functions as a manganese efflux pump
DKE43_RS13000	COG0009	L-threonylcarbamoyladenylate synthase
DKE43_RS13005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DKE43_RS13020	COG2890	protein-(glutamine-N5) methyltransferase activity
DKE43_RS13025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DKE43_RS13030	COG0789	Transcriptional regulator
DKE43_RS13035	COG0679	Auxin Efflux Carrier
DKE43_RS13040	COG0281	malic enzyme
DKE43_RS13045	COG1435	thymidine kinase activity
DKE43_RS13050	COG0254	rRNA binding
DKE43_RS13055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DKE43_RS13060	COG1494	fructose-1,6-bisphosphatase
DKE43_RS13065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DKE43_RS13070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DKE43_RS13075	COG0191	fructose-bisphosphate aldolase activity
DKE43_RS13080	COG2204	response regulator
DKE43_RS13085	COG4821	SIS domain
DKE43_RS13090	COG0504	CTP synthase activity
DKE43_RS13095	COG3343	RNA polymerase activity
DKE43_RS13105	COG1960	acyl-CoA dehydrogenase activity
DKE43_RS13110	COG1960	acyl-CoA dehydrogenase activity
DKE43_RS13115	COG1250	3-hydroxyacyl-CoA dehydrogenase
DKE43_RS13120	COG0183	Belongs to the thiolase family
DKE43_RS13125	COG0247	lactate metabolic process
DKE43_RS13125	COG2181	nitrate reductase activity
DKE43_RS13130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE43_RS13135	COG4294	response to UV
DKE43_RS13145	COG1619	proteins homologs of microcin C7 resistance protein MccF
DKE43_RS13150	COG1132	(ABC) transporter
DKE43_RS13155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKE43_RS13160	COG1619	proteins homologs of microcin C7 resistance protein MccF
DKE43_RS13165	COG0018	arginyl-trna synthetase
DKE43_RS13170	COG4506	Protein conserved in bacteria
DKE43_RS13185	COG0010	Belongs to the arginase family
DKE43_RS13190	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DKE43_RS13195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DKE43_RS13205	COG1994	Peptidase M50
DKE43_RS13210	COG1942	4-Oxalocrotonate Tautomerase
DKE43_RS13220	COG3465	dGTPase activity
DKE43_RS13225	COG1078	dGTPase activity
DKE43_RS13230	COG4844	belongs to the
DKE43_RS13265	COG5444	nuclease activity
DKE43_RS13280	COG0280	phosphate acetyltransferase
DKE43_RS13325	COG1396	sequence-specific DNA binding
DKE43_RS13330	COG3620	sequence-specific DNA binding
DKE43_RS13345	COG1073	alpha beta
DKE43_RS13355	COG1522	sequence-specific DNA binding
DKE43_RS13360	COG2814	Major facilitator Superfamily
DKE43_RS13365	COG0077	Prephenate dehydratase
DKE43_RS13370	COG1917	Cupin 2, conserved barrel domain protein
DKE43_RS13375	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS13380	COG0151	Belongs to the GarS family
DKE43_RS13385	COG0436	Aminotransferase
DKE43_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS13395	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DKE43_RS13400	COG1091	dTDP-4-dehydrorhamnose reductase activity
DKE43_RS13405	COG1088	dTDP-glucose 4,6-dehydratase activity
DKE43_RS13410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DKE43_RS13415	COG3980	spore coat polysaccharide biosynthesis protein
DKE43_RS13420	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DKE43_RS13425	COG2089	acid synthase
DKE43_RS13430	COG0456	acetyltransferase
DKE43_RS13435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DKE43_RS13440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DKE43_RS13445	COG0463	Glycosyl transferase, family 2
DKE43_RS13465	COG2363	Small membrane protein
DKE43_RS13470	COG2233	PERMEase
DKE43_RS13480	COG1012	belongs to the aldehyde dehydrogenase family
DKE43_RS13485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DKE43_RS13490	COG1216	Glycosyl transferase, family 2
DKE43_RS13500	COG0351	phosphomethylpyrimidine kinase
DKE43_RS13520	COG1621	beta-fructofuranosidase activity
DKE43_RS13525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKE43_RS13525	COG1263	PTS System
DKE43_RS13530	COG3711	transcriptional antiterminator
DKE43_RS13540	COG1404	Belongs to the peptidase S8 family
DKE43_RS13550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE43_RS13555	COG0778	Nitroreductase
DKE43_RS13560	COG0772	Belongs to the SEDS family
DKE43_RS13570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DKE43_RS13575	COG1845	cytochrome c oxidase, subunit III
DKE43_RS13580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKE43_RS13585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DKE43_RS13595	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DKE43_RS13600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DKE43_RS13605	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DKE43_RS13620	COG2246	polysaccharide biosynthetic process
DKE43_RS13640	COG3162	membrane
DKE43_RS13645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE43_RS13660	COG0352	thiamine-phosphate diphosphorylase activity
DKE43_RS13665	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DKE43_RS13670	COG0583	DNA-binding transcription factor activity
DKE43_RS13680	COG1346	cytolysis
DKE43_RS13685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DKE43_RS13690	COG0346	lactoylglutathione lyase activity
DKE43_RS13700	COG0765	amino acid transport
DKE43_RS13705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE43_RS13715	COG0457	Tetratricopeptide repeat
DKE43_RS13720	COG2357	RelA SpoT domain protein
DKE43_RS13725	COG1172	Belongs to the binding-protein-dependent transport system permease family
DKE43_RS13730	COG1129	ABC transporter
DKE43_RS13740	COG3420	alginic acid biosynthetic process
DKE43_RS13745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DKE43_RS13760	COG1486	melibiose metabolic process
DKE43_RS13765	COG1447	Phosphotransferase system cellobiose-specific component IIA
DKE43_RS13770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DKE43_RS13775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DKE43_RS13780	COG3711	transcriptional antiterminator
DKE43_RS13780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS13795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKE43_RS13810	COG1595	DNA-templated transcription, initiation
DKE43_RS13820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DKE43_RS13825	COG4988	ABC transporter
DKE43_RS13830	COG1294	oxidase, subunit
DKE43_RS13835	COG1271	oxidase subunit
DKE43_RS13855	COG4509	Sortase family
DKE43_RS13880	COG5386	Cell surface protein
DKE43_RS13885	COG5386	Cell surface protein
DKE43_RS13890	COG1733	regulation of RNA biosynthetic process
DKE43_RS13895	COG2514	catechol 2,3-dioxygenase activity
DKE43_RS13900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE43_RS13900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE43_RS13905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DKE43_RS13905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DKE43_RS13910	COG0346	lactoylglutathione lyase activity
DKE43_RS13915	COG0726	polysaccharide deacetylase
DKE43_RS13920	COG1447	Phosphotransferase system cellobiose-specific component IIA
DKE43_RS13925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DKE43_RS13930	COG2723	6-phospho-beta-galactosidase activity
DKE43_RS13940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DKE43_RS13945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS13945	COG3711	transcriptional antiterminator
DKE43_RS13970	COG1757	Na H antiporter
DKE43_RS13975	COG1027	Aspartate ammonia-lyase
DKE43_RS13980	COG0252	asparaginase activity
DKE43_RS13985	COG1396	sequence-specific DNA binding
DKE43_RS14010	COG4842	Belongs to the WXG100 family
DKE43_RS14015	COG2195	Cleaves the N-terminal amino acid of tripeptides
DKE43_RS14030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DKE43_RS14035	COG2723	6-phospho-beta-galactosidase activity
DKE43_RS14040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKE43_RS14040	COG1263	PTS System
DKE43_RS14040	COG2190	(PTS) system
DKE43_RS14045	COG3711	transcriptional antiterminator
DKE43_RS14050	COG3878	Protein conserved in bacteria
DKE43_RS14060	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DKE43_RS14065	COG1122	ATPase activity
DKE43_RS14070	COG4721	ABC-type cobalt transport system, permease component
DKE43_RS14075	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DKE43_RS14105	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DKE43_RS14110	COG0778	Nitroreductase
DKE43_RS14115	COG1846	Transcriptional regulator
DKE43_RS14120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DKE43_RS14125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DKE43_RS14130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DKE43_RS14135	COG2390	Transcriptional regulator
DKE43_RS14145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DKE43_RS14145	COG2755	lipolytic protein G-D-S-L family
DKE43_RS14165	COG0561	phosphatase activity
DKE43_RS14170	COG0789	Transcriptional regulator
DKE43_RS14175	COG0673	inositol 2-dehydrogenase activity
DKE43_RS14180	COG0840	transmembrane signaling receptor activity
DKE43_RS14185	COG1113	amino acid transport
DKE43_RS14190	COG4335	DNA alkylation repair
DKE43_RS14200	COG1070	Carbohydrate kinase
DKE43_RS14205	COG1737	Transcriptional regulator
DKE43_RS14225	COG0583	DNA-binding transcription factor activity
DKE43_RS14230	COG1609	Transcriptional regulator
DKE43_RS14235	COG2182	Extracellular solute-binding protein
DKE43_RS14240	COG1175	transmembrane transport
DKE43_RS14245	COG3833	ABC-type maltose transport systems, permease component
DKE43_RS14255	COG1874	Beta-galactosidase
DKE43_RS14260	COG2851	Citrate transporter
DKE43_RS14275	COG1131	(ABC) transporter
DKE43_RS14280	COG2824	Alkylphosphonate utilization operon protein PhnA
DKE43_RS14285	COG1929	Belongs to the glycerate kinase type-1 family
DKE43_RS14290	COG2610	gluconate transmembrane transporter activity
DKE43_RS14295	COG3835	regulator
DKE43_RS14300	COG1309	transcriptional regulator
DKE43_RS14305	COG2814	Major facilitator Superfamily
DKE43_RS14315	COG1136	(ABC) transporter
DKE43_RS14325	COG0457	Tetratricopeptide repeat
DKE43_RS14330	COG3711	transcriptional antiterminator
DKE43_RS14335	COG2723	6-phospho-beta-galactosidase activity
DKE43_RS14340	COG1263	PTS System
DKE43_RS14340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKE43_RS14340	COG2190	(PTS) system
DKE43_RS14375	COG1113	amino acid transport
DKE43_RS14380	COG1609	Transcriptional regulator
DKE43_RS14385	COG2814	Major facilitator Superfamily
DKE43_RS14390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DKE43_RS14395	COG2814	Major facilitator Superfamily
DKE43_RS14410	COG5444	nuclease activity
DKE43_RS14425	COG2723	6-phospho-beta-galactosidase activity
DKE43_RS14435	COG2188	Transcriptional regulator
DKE43_RS14460	COG1131	(ABC) transporter
DKE43_RS14465	COG1396	sequence-specific DNA binding
DKE43_RS14470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE43_RS14490	COG1404	Belongs to the peptidase S8 family
DKE43_RS14500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DKE43_RS14510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DKE43_RS14520	COG4720	Psort location CytoplasmicMembrane, score
DKE43_RS14540	COG0456	acetyltransferase
DKE43_RS14545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DKE43_RS14550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DKE43_RS14555	COG4853	Protein conserved in bacteria
DKE43_RS14560	COG4863	YycH protein
DKE43_RS14565	COG5002	protein histidine kinase activity
DKE43_RS14570	COG0745	RESPONSE REGULATOR receiver
DKE43_RS14595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKE43_RS14605	COG2311	Membrane
DKE43_RS14610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKE43_RS14615	COG1309	transcriptional regulator
DKE43_RS14620	COG2124	cytochrome p450
DKE43_RS14625	COG0346	lactoylglutathione lyase activity
DKE43_RS14630	COG0305	Participates in initiation and elongation during chromosome replication
DKE43_RS14645	COG2819	hydrolase of the alpha beta superfamily
DKE43_RS14650	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS14655	COG1169	isochorismate synthase
DKE43_RS14660	COG1021	2,3-dihydroxybenzoate-AMP ligase
DKE43_RS14665	COG3433	isochorismatase activity
DKE43_RS14665	COG1535	isochorismatase
DKE43_RS14670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DKE43_RS14675	COG3251	PFAM MbtH domain protein
DKE43_RS14680	COG2207	Transcriptional regulator
DKE43_RS14680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKE43_RS14685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKE43_RS14690	COG2819	hydrolase of the alpha beta superfamily
DKE43_RS14695	COG3093	addiction module antidote protein HigA
DKE43_RS14700	COG2807	transmembrane transport
DKE43_RS14705	COG0359	binds to the 23S rRNA
DKE43_RS14710	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DKE43_RS14715	COG4241	membrane
DKE43_RS14720	COG1227	inorganic diphosphatase activity
DKE43_RS14730	COG1595	DNA-templated transcription, initiation
DKE43_RS14740	COG0753	catalase activity
DKE43_RS14745	COG0655	NAD(P)H dehydrogenase (quinone) activity
DKE43_RS14750	COG0400	carboxylic ester hydrolase activity
DKE43_RS14755	COG0346	lactoylglutathione lyase activity
DKE43_RS14760	COG1174	glycine betaine transport
DKE43_RS14765	COG1125	glycine betaine transport
DKE43_RS14765	COG0517	IMP dehydrogenase activity
DKE43_RS14770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DKE43_RS14775	COG0629	single-stranded DNA binding
DKE43_RS14780	COG0360	Binds together with S18 to 16S ribosomal RNA
DKE43_RS14785	COG0012	GTP binding
DKE43_RS14790	COG4481	Protein conserved in bacteria
DKE43_RS14805	COG3949	Membrane
DKE43_RS14815	COG1475	DNA binding
DKE43_RS14820	COG1192	Involved in chromosome partitioning
DKE43_RS14830	COG1475	DNA binding
DKE43_RS14835	COG0357	Ribosomal RNA small subunit methyltransferase G
DKE43_RS14840	COG0445	tRNA wobble uridine modification
DKE43_RS14845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DKE43_RS14850	COG1847	R3H domain protein
DKE43_RS14855	COG0706	membrane insertase activity
DKE43_RS14860	COG0594	ribonuclease P activity
DKE43_RS14865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DKE43_RS14870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DKE43_RS14875	COG0592	DNA-directed DNA polymerase activity
DKE43_RS14880	COG2501	S4 domain
DKE43_RS14885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DKE43_RS14895	COG0187	DNA topoisomerase II activity
DKE43_RS14900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DKE43_RS14935	COG0516	GMP reductase activity
DKE43_RS14935	COG0517	IMP dehydrogenase activity
DKE43_RS14940	COG1686	Belongs to the peptidase S11 family
DKE43_RS14945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE43_RS14950	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DKE43_RS14955	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DKE43_RS14960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DKE43_RS14965	COG0840	transmembrane signaling receptor activity
DKE43_RS14975	COG1428	Deoxynucleoside kinase
DKE43_RS14980	COG1428	Deoxynucleoside kinase
DKE43_RS14985	COG3858	chitin binding
DKE43_RS14985	COG1388	LysM domain
DKE43_RS14990	COG1335	isochorismatase
DKE43_RS14995	COG0590	tRNA wobble adenosine to inosine editing
DKE43_RS15005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DKE43_RS15010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DKE43_RS15015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DKE43_RS15060	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DKE43_RS15065	COG3853	Toxic anion resistance protein (TelA)
DKE43_RS15070	COG1982	Orn Lys Arg decarboxylase major
DKE43_RS15075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DKE43_RS15080	COG3870	Protein conserved in bacteria
DKE43_RS15085	COG1728	Protein conserved in bacteria
DKE43_RS15090	COG0470	DNA polymerase III
DKE43_RS15095	COG1774	PSP1 C-terminal conserved region
DKE43_RS15100	COG4467	Involved in initiation control of chromosome replication
DKE43_RS15105	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DKE43_RS15110	COG2827	Endonuclease containing a URI domain
DKE43_RS15115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DKE43_RS15120	COG2002	toxin-antitoxin pair type II binding
DKE43_RS15125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE43_RS15125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKE43_RS15130	COG0084	hydrolase, TatD family'
DKE43_RS15135	COG3583	domain protein
DKE43_RS15135	COG3584	3D domain protein
DKE43_RS15140	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DKE43_RS15145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKE43_RS15155	COG4466	Protein conserved in bacteria
DKE43_RS15165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DKE43_RS15170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DKE43_RS15175	COG0251	oxidation-reduction process
DKE43_RS15180	COG2088	sporulation resulting in formation of a cellular spore
DKE43_RS15190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKE43_RS15195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DKE43_RS15200	COG0193	aminoacyl-tRNA hydrolase activity
DKE43_RS15210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DKE43_RS15215	COG2002	toxin-antitoxin pair type II binding
DKE43_RS15220	COG2244	polysaccharide biosynthetic process
DKE43_RS15225	COG3956	TIGRFAM MazG family protein
DKE43_RS15230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DKE43_RS15245	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DKE43_RS15250	COG1098	S1 RNA binding domain
DKE43_RS15265	COG2208	phosphoserine phosphatase activity
DKE43_RS15270	COG2304	oxidoreductase activity
DKE43_RS15275	COG0515	serine threonine protein kinase
DKE43_RS15280	COG0037	tRNA processing
DKE43_RS15285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DKE43_RS15290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKE43_RS15295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DKE43_RS15300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKE43_RS15305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKE43_RS15310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DKE43_RS15315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DKE43_RS15320	COG0512	Glutamine amidotransferase of anthranilate synthase
DKE43_RS15325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DKE43_RS15330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DKE43_RS15335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DKE43_RS15340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DKE43_RS15345	COG1396	sequence-specific DNA binding
DKE43_RS15350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE43_RS15355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DKE43_RS15435	COG4463	regulation of RNA biosynthetic process
DKE43_RS15440	COG3880	PFAM UvrB UvrC protein
DKE43_RS15445	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DKE43_RS15450	COG0542	response to heat
DKE43_RS15455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DKE43_RS15460	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DKE43_RS15465	COG4956	integral membrane protein (PIN domain superfamily)
DKE43_RS15470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DKE43_RS15475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DKE43_RS15480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKE43_RS15485	COG1045	serine acetyltransferase
DKE43_RS15490	COG0215	cysteine-tRNA ligase activity
DKE43_RS15495	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DKE43_RS15500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKE43_RS15505	COG3688	RNA-binding protein containing a PIN domain
DKE43_RS15510	COG1595	DNA-templated transcription, initiation
DKE43_RS15515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DKE43_RS15520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DKE43_RS15525	COG0250	Participates in transcription elongation, termination and antitermination
DKE43_RS15535	COG0081	regulation of translation
DKE43_RS15540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DKE43_RS15545	COG0222	ribosome binding
DKE43_RS15550	COG2813	Specifically methylates the guanine in position
DKE43_RS15555	COG0085	RNA polymerase activity
DKE43_RS15560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DKE43_RS15565	COG1358	cellular component organization or biogenesis
DKE43_RS15570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DKE43_RS15575	COG0049	tRNA binding
DKE43_RS15580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DKE43_RS15585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKE43_RS15590	COG0596	Alpha beta hydrolase
DKE43_RS15600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKE43_RS15605	COG0088	Forms part of the polypeptide exit tunnel
DKE43_RS15610	COG0089	rRNA binding
DKE43_RS15615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DKE43_RS15620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DKE43_RS15625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DKE43_RS15630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DKE43_RS15640	COG0255	Belongs to the universal ribosomal protein uL29 family
DKE43_RS15645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DKE43_RS15650	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DKE43_RS15655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DKE43_RS15660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DKE43_RS15665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DKE43_RS15670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DKE43_RS15675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DKE43_RS15680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DKE43_RS15685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DKE43_RS15690	COG1841	ribosomal large subunit assembly
DKE43_RS15695	COG0200	Binds to the 23S rRNA
DKE43_RS15700	COG0201	protein transport
DKE43_RS15705	COG0563	adenylate kinase activity
DKE43_RS15710	COG0024	Methionine aminopeptidase
DKE43_RS15720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DKE43_RS15725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DKE43_RS15730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DKE43_RS15735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DKE43_RS15740	COG0202	RNA polymerase activity
DKE43_RS15745	COG0203	ribosomal protein L17
DKE43_RS15750	COG1122	ATPase activity
DKE43_RS15755	COG1122	ATPase activity
DKE43_RS15760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DKE43_RS15765	COG0101	tRNA pseudouridine synthase activity
DKE43_RS15770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DKE43_RS15775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKE43_RS15780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKE43_RS15810	COG0860	N-Acetylmuramoyl-L-alanine amidase
DKE43_RS15815	COG0489	protein tyrosine kinase activity
DKE43_RS15825	COG2194	sulfuric ester hydrolase activity
DKE43_RS15830	COG0726	polysaccharide deacetylase
DKE43_RS15860	COG0659	secondary active sulfate transmembrane transporter activity
DKE43_RS15865	COG0385	Bile acid
DKE43_RS15870	COG3876	Protein conserved in bacteria
DKE43_RS15875	COG1472	Belongs to the glycosyl hydrolase 3 family
DKE43_RS15880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DKE43_RS15885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKE43_RS15885	COG1263	PTS System
DKE43_RS15890	COG1737	Transcriptional regulator
DKE43_RS15895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DKE43_RS15930	COG1595	DNA-templated transcription, initiation
DKE43_RS15935	COG5662	AntiSigma factor
DKE43_RS15940	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DKE43_RS15945	COG4856	YbbR-like protein
DKE43_RS15950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DKE43_RS15955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DKE43_RS15975	COG0084	hydrolase, TatD family'
DKE43_RS15990	COG1131	(ABC) transporter
DKE43_RS16005	COG1131	(ABC) transporter
DKE43_RS16015	COG1413	lyase activity
DKE43_RS16025	COG2311	Membrane
DKE43_RS16050	COG1309	transcriptional regulator
DKE43_RS16065	COG1113	amino acid transport
DKE43_RS16070	COG0584	glycerophosphoryl diester phosphodiesterase
DKE43_RS16075	COG2271	Major facilitator Superfamily
DKE43_RS16085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKE43_RS16090	COG1331	Highly conserved protein containing a thioredoxin domain
DKE43_RS16100	COG1131	(ABC) transporter
DKE43_RS16130	COG1937	Protein conserved in bacteria
DKE43_RS16135	COG2210	Belongs to the sulfur carrier protein TusA family
DKE43_RS16140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DKE43_RS16145	COG0425	Belongs to the sulfur carrier protein TusA family
DKE43_RS16145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DKE43_RS16150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKE43_RS16150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DKE43_RS16155	COG0425	Belongs to the sulfur carrier protein TusA family
DKE43_RS16160	COG0730	response to heat
DKE43_RS16165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DKE43_RS16170	COG2814	Major facilitator Superfamily
DKE43_RS16175	COG1846	Transcriptional regulator
DKE43_RS16185	COG1683	Conserved Protein
DKE43_RS16195	COG0656	L-ascorbic acid biosynthetic process
DKE43_RS16200	COG0371	Dehydrogenase
DKE43_RS16205	COG1054	Belongs to the UPF0176 family
DKE43_RS16210	COG0531	amino acid
DKE43_RS16220	COG3711	transcriptional antiterminator
DKE43_RS16225	COG1263	PTS System
DKE43_RS16225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKE43_RS16225	COG2190	(PTS) system
DKE43_RS16230	COG2723	6-phospho-beta-galactosidase activity
DKE43_RS16245	COG3711	transcriptional antiterminator
DKE43_RS16245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS16250	COG1940	carbohydrate kinase activity
DKE43_RS16255	COG0383	alpha-mannosidase activity
DKE43_RS16260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE43_RS16265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKE43_RS16275	COG1404	Belongs to the peptidase S8 family
DKE43_RS16290	COG0833	amino acid
DKE43_RS16295	COG2040	homocysteine
DKE43_RS16300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DKE43_RS16305	COG1695	Transcriptional regulator
DKE43_RS16315	COG2814	Major facilitator Superfamily
DKE43_RS16320	COG0456	acetyltransferase
DKE43_RS16335	COG1404	Belongs to the peptidase S8 family
DKE43_RS16345	COG1309	transcriptional regulator
DKE43_RS16350	COG1917	Cupin 2, conserved barrel domain protein
DKE43_RS16355	COG1063	alcohol dehydrogenase
DKE43_RS16360	COG1846	Transcriptional regulator
DKE43_RS16365	COG0318	PFAM AMP-dependent synthetase and ligase
DKE43_RS16370	COG0531	amino acid
DKE43_RS16385	COG0596	Alpha beta hydrolase
DKE43_RS16390	COG1115	amino acid carrier protein
DKE43_RS16395	COG2066	Belongs to the glutaminase family
DKE43_RS16400	COG4191	Histidine kinase
DKE43_RS16405	COG0784	Response regulator, receiver
DKE43_RS16410	COG3012	SEC-C Motif Domain Protein
DKE43_RS16410	COG1405	negative regulation of cell septum assembly
DKE43_RS16420	COG0667	Aldo Keto reductase
DKE43_RS16425	COG3290	protein histidine kinase activity
DKE43_RS16430	COG3279	Response regulator of the LytR AlgR family
DKE43_RS16435	COG4555	ABC transporter
DKE43_RS16440	COG1668	transmembrane transport
DKE43_RS16460	COG3773	Cell wall hydrolase
DKE43_RS16465	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS16475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE43_RS16480	COG2310	stress, protein
DKE43_RS16485	COG2310	stress, protein
DKE43_RS16490	COG2310	stress, protein
DKE43_RS16495	COG0861	Integral membrane protein TerC family
DKE43_RS16525	COG3853	Toxic anion resistance protein (TelA)
DKE43_RS16530	COG4175	Glycine betaine
DKE43_RS16530	COG0517	IMP dehydrogenase activity
DKE43_RS16535	COG4176	ABC-type proline glycine betaine transport system permease component
DKE43_RS16540	COG2113	Glycine betaine
DKE43_RS16555	COG1473	amidohydrolase
DKE43_RS16560	COG1288	antiporter activity
DKE43_RS16565	COG0039	L-malate dehydrogenase activity
DKE43_RS16570	COG1620	l-lactate permease
DKE43_RS16575	COG1609	Transcriptional regulator
DKE43_RS16580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DKE43_RS16585	COG0561	phosphatase activity
DKE43_RS16590	COG0673	inositol 2-dehydrogenase activity
DKE43_RS16595	COG0738	Major facilitator superfamily
DKE43_RS16600	COG1280	lysine exporter protein (LysE YggA)
DKE43_RS16610	COG3403	YqcI/YcgG family
DKE43_RS16615	COG1113	amino acid transport
DKE43_RS16620	COG3665	Urea carboxylase-associated protein
DKE43_RS16625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DKE43_RS16630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKE43_RS16640	COG0477	Major facilitator Superfamily
DKE43_RS16645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DKE43_RS16650	COG2226	methyltransferase
DKE43_RS16655	COG0583	DNA-binding transcription factor activity
DKE43_RS16660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKE43_RS16665	COG3458	cephalosporin-C deacetylase activity
DKE43_RS16675	COG3541	Predicted nucleotidyltransferase
DKE43_RS16680	COG0506	proline dehydrogenase activity
DKE43_RS16685	COG1012	belongs to the aldehyde dehydrogenase family
DKE43_RS16690	COG2508	Transcriptional regulator
DKE43_RS16695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DKE43_RS16700	COG0765	amino acid transport
DKE43_RS16705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE43_RS16715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DKE43_RS16720	COG1522	sequence-specific DNA binding
DKE43_RS16725	COG2746	aminoglycoside 3-N-acetyltransferase activity
DKE43_RS16735	COG3290	protein histidine kinase activity
DKE43_RS16735	COG0840	transmembrane signaling receptor activity
DKE43_RS16740	COG3209	COG3209 Rhs family protein
DKE43_RS16765	COG3842	ATPase activity
DKE43_RS16770	COG1176	ABC-type spermidine putrescine transport system, permease component I
DKE43_RS16780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DKE43_RS16785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DKE43_RS16790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DKE43_RS16805	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DKE43_RS16820	COG4555	ABC transporter
DKE43_RS16835	COG0697	spore germination
DKE43_RS16840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE43_RS16850	COG2364	Membrane
DKE43_RS16855	COG1126	abc transporter atp-binding protein
DKE43_RS16860	COG0765	amino acid transport
DKE43_RS16865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE43_RS16870	COG0833	amino acid
DKE43_RS16875	COG3104	oligopeptide transport
DKE43_RS16880	COG5434	Belongs to the glycosyl hydrolase 28 family
DKE43_RS16885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKE43_RS16890	COG0456	acetyltransferase
DKE43_RS16895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKE43_RS16900	COG0765	amino acid transport
DKE43_RS16905	COG1126	abc transporter atp-binding protein
DKE43_RS16910	COG1473	amidohydrolase
DKE43_RS16915	COG2079	MmgE PrpD family protein
DKE43_RS16920	COG1366	Belongs to the anti-sigma-factor antagonist family
DKE43_RS16925	COG0527	aspartate kinase activity
DKE43_RS16930	COG2814	Major facilitator Superfamily
DKE43_RS16935	COG1309	transcriptional regulator
DKE43_RS16945	COG0640	Transcriptional regulator
DKE43_RS16950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKE43_RS16955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DKE43_RS16960	COG0531	amino acid
DKE43_RS16965	COG1012	belongs to the aldehyde dehydrogenase family
DKE43_RS16970	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKE43_RS16975	COG4549	nuclear export factor GLE1
DKE43_RS16980	COG1276	copper resistance
DKE43_RS16980	COG2372	response to copper ion
DKE43_RS16985	COG2213	PTS system mannitol-specific
DKE43_RS16990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKE43_RS16995	COG0246	Mannitol dehydrogenase
DKE43_RS17000	COG0840	transmembrane signaling receptor activity
DKE43_RS17020	COG0346	lactoylglutathione lyase activity
DKE43_RS17030	COG0561	phosphatase activity
DKE43_RS17035	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DKE43_RS17040	COG1914	H( )-stimulated, divalent metal cation uptake system
DKE43_RS17045	COG4336	lyase activity
DKE43_RS17050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DKE43_RS17055	COG1984	allophanate hydrolase subunit 2
DKE43_RS17060	COG1414	Transcriptional regulator
DKE43_RS17065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DKE43_RS17070	COG2755	lipolytic protein G-D-S-L family
DKE43_RS17080	COG3711	transcriptional antiterminator
DKE43_RS17085	COG2226	methyltransferase
DKE43_RS17090	COG1028	Short-chain dehydrogenase reductase Sdr
DKE43_RS17095	COG3871	stress protein (general stress protein 26)
DKE43_RS17115	COG2814	Major facilitator Superfamily
DKE43_RS17120	COG1802	Transcriptional regulator
DKE43_RS17125	COG2207	Transcriptional regulator
DKE43_RS17125	COG1917	Cupin 2, conserved barrel domain protein
DKE43_RS17130	COG0697	spore germination
DKE43_RS17135	COG0473	3-isopropylmalate dehydrogenase activity
DKE43_RS17140	COG0551	DNA topoisomerase type I activity
DKE43_RS17140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DKE43_RS17145	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DKE43_RS17150	COG3706	GGDEF domain
DKE43_RS17155	COG5298	Protein conserved in bacteria
DKE43_RS17160	COG1215	transferase activity, transferring glycosyl groups
DKE43_RS17170	COG0531	amino acid
DKE43_RS17175	COG0028	Belongs to the TPP enzyme family
DKE43_RS17180	COG5444	nuclease activity
DKE43_RS17205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKE43_RS17210	COG1914	H( )-stimulated, divalent metal cation uptake system
DKE43_RS17215	COG2261	transglycosylase associated protein
DKE43_RS17220	COG2217	Heavy metal translocating P-type atpase
DKE43_RS17225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DKE43_RS17230	COG3290	protein histidine kinase activity
DKE43_RS17235	COG4565	transcriptional regulatory protein
DKE43_RS17240	COG1301	dicarboxylic acid transport
DKE43_RS17245	COG0628	permease
DKE43_RS17250	COG1301	dicarboxylic acid transport
DKE43_RS17255	COG1131	(ABC) transporter
DKE43_RS17260	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DKE43_RS17275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKE43_RS17280	COG1181	Belongs to the D-alanine--D-alanine ligase family
DKE43_RS17285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DKE43_RS17300	COG0513	Belongs to the DEAD box helicase family
DKE43_RS17305	COG3402	PFAM membrane-flanked domain
DKE43_RS17310	COG3428	Bacterial PH domain
DKE43_RS17315	COG0705	Rhomboid family
DKE43_RS17320	COG0736	holo-[acyl-carrier-protein] synthase activity
DKE43_RS17325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DKE43_RS17330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKE43_RS17335	COG0864	Transcriptional regulator
DKE43_RS17340	COG2337	Toxic component of a toxin-antitoxin (TA) module
DKE43_RS17345	COG1366	Belongs to the anti-sigma-factor antagonist family
DKE43_RS17350	COG1366	Belongs to the anti-sigma-factor antagonist family
DKE43_RS17355	COG2172	sigma factor antagonist activity
DKE43_RS17360	COG2208	phosphoserine phosphatase activity
DKE43_RS17365	COG1366	Belongs to the anti-sigma-factor antagonist family
DKE43_RS17370	COG2172	sigma factor antagonist activity
DKE43_RS17375	COG1191	sigma factor activity
DKE43_RS17380	COG2208	phosphoserine phosphatase activity
DKE43_RS17385	COG2183	response to ionizing radiation
DKE43_RS17395	COG3091	SprT-like family
DKE43_RS17400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DKE43_RS17405	COG0022	dehydrogenase e1 component
DKE43_RS17410	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKE43_RS17415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKE43_RS17420	COG3284	Transcriptional regulator
DKE43_RS17460	COG0582	viral genome integration into host DNA
DKE43_RS17465	COG2856	Zn peptidase
DKE43_RS17470	COG1396	sequence-specific DNA binding
DKE43_RS17495	COG1674	ftsk spoiiie
DKE43_RS17500	COG2946	Replication initiation factor
DKE43_RS17590	COG0433	COG0433 Predicted ATPase
DKE43_RS17595	COG5644	endopeptidase inhibitor activity
DKE43_RS17600	COG0791	NLP P60 protein
DKE43_RS17600	COG0741	lytic transglycosylase activity
DKE43_RS17610	COG0457	Tetratricopeptide repeat
DKE43_RS17630	COG1278	Cold shock
DKE43_RS17635	COG1329	Transcriptional regulator
DKE43_RS17640	COG1064	alcohol dehydrogenase
DKE43_RS17645	COG0789	Transcriptional regulator
DKE43_RS17660	COG0477	Major facilitator Superfamily
DKE43_RS17665	COG0657	acetylesterase activity
DKE43_RS17695	COG0252	asparaginase activity
DKE43_RS17715	COG2814	Major facilitator Superfamily
DKE43_RS17750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DKE43_RS17755	COG1846	Transcriptional regulator
DKE43_RS17760	COG0778	Nitroreductase
DKE43_RS17775	COG1396	sequence-specific DNA binding
DKE43_RS17785	COG0456	acetyltransferase
DKE43_RS17790	COG0583	DNA-binding transcription factor activity
DKE43_RS17795	COG0667	Aldo Keto reductase
DKE43_RS17805	COG4122	O-methyltransferase activity
DKE43_RS17815	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DKE43_RS17820	COG0697	spore germination
DKE43_RS17830	COG1301	dicarboxylic acid transport
DKE43_RS17870	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DKE43_RS17875	COG0802	atpase or kinase
DKE43_RS17880	COG1214	PFAM Peptidase M22, glycoprotease
DKE43_RS17885	COG0456	acetyltransferase
DKE43_RS17890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DKE43_RS17895	COG0488	(ABC) transporter
DKE43_RS17900	COG0315	cyclic pyranopterin monophosphate synthase activity
DKE43_RS17905	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DKE43_RS17910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DKE43_RS17915	COG0805	protein transport
DKE43_RS17920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DKE43_RS17930	COG1266	CAAX protease self-immunity
DKE43_RS17935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DKE43_RS17940	COG0459	protein refolding
DKE43_RS17950	COG1846	Transcriptional regulator
DKE43_RS17955	COG0456	acetyltransferase
DKE43_RS17960	COG2808	Putative FMN-binding domain
DKE43_RS17980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DKE43_RS17985	COG0823	Involved in the tonB-independent uptake of proteins
DKE43_RS18000	COG2132	Multicopper oxidase
DKE43_RS18005	COG1113	amino acid transport
DKE43_RS18010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DKE43_RS18015	COG0714	Associated with various cellular activities
DKE43_RS18020	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DKE43_RS18025	COG1305	Transglutaminase-like
DKE43_RS18030	COG0519	Catalyzes the synthesis of GMP from XMP
DKE43_RS18030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKE43_RS18035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DKE43_RS18040	COG1917	Cupin 2, conserved barrel domain protein
DKE43_RS18040	COG2207	Transcriptional regulator
DKE43_RS18045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DKE43_RS18050	COG2207	Transcriptional regulator
DKE43_RS18075	COG2814	Major facilitator Superfamily
DKE43_RS18080	COG0583	DNA-binding transcription factor activity
DKE43_RS18085	COG2252	PERMEase
DKE43_RS18095	COG3064	Membrane
DKE43_RS18100	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DKE43_RS18110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DKE43_RS18115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DKE43_RS18120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DKE43_RS18125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DKE43_RS18130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DKE43_RS18135	COG0047	phosphoribosylformylglycinamidine synthase activity
DKE43_RS18140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DKE43_RS18145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DKE43_RS18150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DKE43_RS18155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKE43_RS18160	COG0138	bifunctional purine biosynthesis protein purh
DKE43_RS18165	COG0151	Belongs to the GarS family
DKE43_RS18185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DKE43_RS18190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DKE43_RS18195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DKE43_RS18200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKE43_RS18210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DKE43_RS18215	COG4496	protein, YerC YecD
DKE43_RS18220	COG0069	glutamate synthase activity
DKE43_RS18235	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DKE43_RS18240	COG0210	DNA helicase
DKE43_RS18245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DKE43_RS18250	COG4851	CamS sex pheromone cAM373 precursor
DKE43_RS18265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DKE43_RS18280	COG1250	3-hydroxyacyl-CoA dehydrogenase
DKE43_RS18295	COG1960	acyl-CoA dehydrogenase activity
DKE43_RS18325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKE43_RS18330	COG1785	Belongs to the alkaline phosphatase family
DKE43_RS18335	COG1285	pathogenesis
DKE43_RS18340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKE43_RS18345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE43_RS18350	COG0154	amidase activity
DKE43_RS18355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKE43_RS18360	COG1309	transcriptional regulator
DKE43_RS18365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKE43_RS18375	COG1597	lipid kinase activity
DKE43_RS18380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DKE43_RS18395	COG0457	Tetratricopeptide repeat
DKE43_RS18400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKE43_RS18410	COG1737	Transcriptional regulator
DKE43_RS18415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKE43_RS18415	COG1263	PTS System
DKE43_RS18430	COG1959	2 iron, 2 sulfur cluster binding
DKE43_RS18435	COG0492	ferredoxin-NADP+ reductase activity
DKE43_RS18450	COG1486	melibiose metabolic process
DKE43_RS18460	COG2211	Major facilitator Superfamily
DKE43_RS18490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DKE43_RS18495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DKE43_RS18500	COG1442	glycosyl transferase family 8
DKE43_RS18505	COG1216	Glycosyl transferase, family 2
DKE43_RS18510	COG1442	glycosyl transferase family 8
DKE43_RS18515	COG2223	nitrite transmembrane transporter activity
DKE43_RS18525	COG0471	metal ion transport
DKE43_RS18530	COG0531	amino acid
DKE43_RS18535	COG0457	Tetratricopeptide repeat
DKE43_RS18535	COG0463	Glycosyl transferase, family 2
DKE43_RS18540	COG0488	(ABC) transporter
DKE43_RS18545	COG1469	GTP cyclohydrolase I activity
DKE43_RS18550	COG0789	Transcriptional regulator
DKE43_RS18555	COG2814	Major facilitator Superfamily
DKE43_RS18560	COG0488	(ABC) transporter
DKE43_RS18565	COG0513	Belongs to the DEAD box helicase family
DKE43_RS18570	COG2130	NADP-dependent
DKE43_RS18590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE43_RS18590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKE43_RS18595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DKE43_RS18605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DKE43_RS18605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate