locus-tag	class	description
M5E03_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5E03_RS00010	COG0592	DNA-directed DNA polymerase activity
M5E03_RS00015	COG2501	S4 domain
M5E03_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M5E03_RS00030	COG0187	DNA topoisomerase II activity
M5E03_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5E03_RS00070	COG0516	GMP reductase activity
M5E03_RS00070	COG0517	IMP dehydrogenase activity
M5E03_RS00075	COG1686	Belongs to the peptidase S11 family
M5E03_RS00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_RS00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M5E03_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M5E03_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M5E03_RS00110	COG1428	Deoxynucleoside kinase
M5E03_RS00115	COG1428	Deoxynucleoside kinase
M5E03_RS00120	COG3858	chitin binding
M5E03_RS00120	COG1388	LysM domain
M5E03_RS00125	COG1335	isochorismatase
M5E03_RS00130	COG0590	tRNA wobble adenosine to inosine editing
M5E03_RS00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M5E03_RS00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M5E03_RS00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M5E03_RS00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M5E03_RS00200	COG3853	Toxic anion resistance protein (TelA)
M5E03_RS00205	COG1982	Orn Lys Arg decarboxylase major
M5E03_RS00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M5E03_RS00215	COG3870	Protein conserved in bacteria
M5E03_RS00220	COG1728	Protein conserved in bacteria
M5E03_RS00225	COG0470	DNA polymerase III
M5E03_RS00230	COG1774	PSP1 C-terminal conserved region
M5E03_RS00235	COG4467	Involved in initiation control of chromosome replication
M5E03_RS00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M5E03_RS00245	COG2827	Endonuclease containing a URI domain
M5E03_RS00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M5E03_RS00255	COG2002	toxin-antitoxin pair type II binding
M5E03_RS00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_RS00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_RS00265	COG0084	hydrolase, TatD family'
M5E03_RS00280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M5E03_RS00285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M5E03_RS00295	COG4466	Protein conserved in bacteria
M5E03_RS00305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M5E03_RS00310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E03_RS00315	COG0251	oxidation-reduction process
M5E03_RS00320	COG2088	sporulation resulting in formation of a cellular spore
M5E03_RS00330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M5E03_RS00335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M5E03_RS00340	COG0193	aminoacyl-tRNA hydrolase activity
M5E03_RS00350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5E03_RS00355	COG2002	toxin-antitoxin pair type II binding
M5E03_RS00360	COG2244	polysaccharide biosynthetic process
M5E03_RS00365	COG3956	TIGRFAM MazG family protein
M5E03_RS00370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M5E03_RS00385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M5E03_RS00390	COG1098	S1 RNA binding domain
M5E03_RS00405	COG2208	phosphoserine phosphatase activity
M5E03_RS00410	COG2304	oxidoreductase activity
M5E03_RS00415	COG0515	serine threonine protein kinase
M5E03_RS00420	COG0037	tRNA processing
M5E03_RS00425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M5E03_RS00430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5E03_RS00435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M5E03_RS00440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M5E03_RS00445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E03_RS00450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E03_RS00455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M5E03_RS00460	COG0512	Glutamine amidotransferase of anthranilate synthase
M5E03_RS00465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E03_RS00470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M5E03_RS00475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M5E03_RS00480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5E03_RS00485	COG1396	sequence-specific DNA binding
M5E03_RS00490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E03_RS00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M5E03_RS00575	COG4463	regulation of RNA biosynthetic process
M5E03_RS00580	COG3880	PFAM UvrB UvrC protein
M5E03_RS00585	COG3869	Catalyzes the specific phosphorylation of arginine residues in
M5E03_RS00590	COG0542	response to heat
M5E03_RS00595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M5E03_RS00600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M5E03_RS00605	COG4956	integral membrane protein (PIN domain superfamily)
M5E03_RS00610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M5E03_RS00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M5E03_RS00620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5E03_RS00625	COG1045	serine acetyltransferase
M5E03_RS00630	COG0215	cysteine-tRNA ligase activity
M5E03_RS00635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M5E03_RS00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E03_RS00645	COG3688	RNA-binding protein containing a PIN domain
M5E03_RS00650	COG1595	DNA-templated transcription, initiation
M5E03_RS00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M5E03_RS00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5E03_RS00665	COG0250	Participates in transcription elongation, termination and antitermination
M5E03_RS00675	COG0081	regulation of translation
M5E03_RS00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M5E03_RS00685	COG0222	ribosome binding
M5E03_RS00690	COG2813	Specifically methylates the guanine in position
M5E03_RS00695	COG0085	RNA polymerase activity
M5E03_RS00700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M5E03_RS00705	COG1358	cellular component organization or biogenesis
M5E03_RS00710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M5E03_RS00715	COG0049	tRNA binding
M5E03_RS00720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5E03_RS00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5E03_RS00730	COG0596	Alpha beta hydrolase
M5E03_RS00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M5E03_RS00745	COG0088	Forms part of the polypeptide exit tunnel
M5E03_RS00750	COG0089	rRNA binding
M5E03_RS00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M5E03_RS00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M5E03_RS00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M5E03_RS00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M5E03_RS00780	COG0255	Belongs to the universal ribosomal protein uL29 family
M5E03_RS00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M5E03_RS00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M5E03_RS00795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M5E03_RS00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M5E03_RS00805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5E03_RS00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M5E03_RS00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M5E03_RS00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M5E03_RS00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M5E03_RS00830	COG1841	ribosomal large subunit assembly
M5E03_RS00835	COG0200	Binds to the 23S rRNA
M5E03_RS00840	COG0201	protein transport
M5E03_RS00845	COG0563	adenylate kinase activity
M5E03_RS00850	COG0024	Methionine aminopeptidase
M5E03_RS00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M5E03_RS00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M5E03_RS00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M5E03_RS00875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M5E03_RS00880	COG0202	RNA polymerase activity
M5E03_RS00885	COG0203	ribosomal protein L17
M5E03_RS00890	COG1122	ATPase activity
M5E03_RS00895	COG1122	ATPase activity
M5E03_RS00900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5E03_RS00905	COG0101	tRNA pseudouridine synthase activity
M5E03_RS00910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M5E03_RS00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M5E03_RS00960	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M5E03_RS00965	COG3421	Type III restriction
M5E03_RS00975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_RS01000	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_RS01005	COG0489	protein tyrosine kinase activity
M5E03_RS01015	COG2194	sulfuric ester hydrolase activity
M5E03_RS01020	COG0726	polysaccharide deacetylase
M5E03_RS01050	COG0659	secondary active sulfate transmembrane transporter activity
M5E03_RS01055	COG0385	Bile acid
M5E03_RS01060	COG3876	Protein conserved in bacteria
M5E03_RS01065	COG1472	Belongs to the glycosyl hydrolase 3 family
M5E03_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5E03_RS01075	COG1263	PTS System
M5E03_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS01080	COG1737	Transcriptional regulator
M5E03_RS01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M5E03_RS01120	COG1595	DNA-templated transcription, initiation
M5E03_RS01125	COG5662	AntiSigma factor
M5E03_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M5E03_RS01135	COG4856	YbbR-like protein
M5E03_RS01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E03_RS01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M5E03_RS01165	COG1131	(ABC) transporter
M5E03_RS01180	COG1131	(ABC) transporter
M5E03_RS01190	COG1413	lyase activity
M5E03_RS01220	COG2311	Membrane
M5E03_RS01240	COG1113	amino acid transport
M5E03_RS01245	COG0584	glycerophosphoryl diester phosphodiesterase
M5E03_RS01250	COG2271	Major facilitator Superfamily
M5E03_RS01260	COG1331	Highly conserved protein containing a thioredoxin domain
M5E03_RS01285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5E03_RS01295	COG1331	Highly conserved protein containing a thioredoxin domain
M5E03_RS01310	COG1937	Protein conserved in bacteria
M5E03_RS01315	COG2210	Belongs to the sulfur carrier protein TusA family
M5E03_RS01325	COG0425	Belongs to the sulfur carrier protein TusA family
M5E03_RS01325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E03_RS01330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_RS01330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E03_RS01335	COG0425	Belongs to the sulfur carrier protein TusA family
M5E03_RS01340	COG0730	response to heat
M5E03_RS01350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5E03_RS01355	COG2814	Major facilitator Superfamily
M5E03_RS01365	COG1846	Transcriptional regulator
M5E03_RS01375	COG1683	Conserved Protein
M5E03_RS01385	COG0656	L-ascorbic acid biosynthetic process
M5E03_RS01390	COG0371	Dehydrogenase
M5E03_RS01395	COG1054	Belongs to the UPF0176 family
M5E03_RS01400	COG0531	amino acid
M5E03_RS01410	COG3711	transcriptional antiterminator
M5E03_RS01415	COG1263	PTS System
M5E03_RS01415	COG2190	(PTS) system
M5E03_RS01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS01420	COG2723	6-phospho-beta-galactosidase activity
M5E03_RS01440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS01440	COG3711	transcriptional antiterminator
M5E03_RS01445	COG1940	carbohydrate kinase activity
M5E03_RS01450	COG0383	alpha-mannosidase activity
M5E03_RS01455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_RS01460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_RS01470	COG1404	Belongs to the peptidase S8 family
M5E03_RS01485	COG0833	amino acid
M5E03_RS01490	COG2040	homocysteine
M5E03_RS01495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_RS01500	COG1695	Transcriptional regulator
M5E03_RS01515	COG2814	Major facilitator Superfamily
M5E03_RS01520	COG0456	acetyltransferase
M5E03_RS01535	COG1404	Belongs to the peptidase S8 family
M5E03_RS01545	COG1309	transcriptional regulator
M5E03_RS01550	COG1917	Cupin 2, conserved barrel domain protein
M5E03_RS01555	COG1063	alcohol dehydrogenase
M5E03_RS01560	COG1846	Transcriptional regulator
M5E03_RS01565	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_RS01570	COG0531	amino acid
M5E03_RS01580	COG0596	Alpha beta hydrolase
M5E03_RS01585	COG1115	amino acid carrier protein
M5E03_RS01590	COG2066	Belongs to the glutaminase family
M5E03_RS01595	COG4191	Histidine kinase
M5E03_RS01600	COG0784	Response regulator, receiver
M5E03_RS01605	COG1405	negative regulation of cell septum assembly
M5E03_RS01605	COG3012	SEC-C Motif Domain Protein
M5E03_RS01615	COG2197	response regulator
M5E03_RS01620	COG4585	Histidine kinase
M5E03_RS01630	COG0667	Aldo Keto reductase
M5E03_RS01635	COG3290	protein histidine kinase activity
M5E03_RS01640	COG3279	Response regulator of the LytR AlgR family
M5E03_RS01645	COG4555	ABC transporter
M5E03_RS01650	COG1668	transmembrane transport
M5E03_RS01660	COG3773	Cell wall hydrolase
M5E03_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_RS01680	COG2310	stress, protein
M5E03_RS01685	COG2310	stress, protein
M5E03_RS01690	COG2310	stress, protein
M5E03_RS01695	COG0861	Integral membrane protein TerC family
M5E03_RS01725	COG3853	Toxic anion resistance protein (TelA)
M5E03_RS01730	COG0517	IMP dehydrogenase activity
M5E03_RS01730	COG4175	Glycine betaine
M5E03_RS01735	COG4176	ABC-type proline glycine betaine transport system permease component
M5E03_RS01740	COG2113	Glycine betaine
M5E03_RS01745	COG0596	Alpha beta hydrolase
M5E03_RS01755	COG1473	amidohydrolase
M5E03_RS01760	COG1288	antiporter activity
M5E03_RS01765	COG0039	L-malate dehydrogenase activity
M5E03_RS01770	COG1620	l-lactate permease
M5E03_RS01775	COG1609	Transcriptional regulator
M5E03_RS01780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E03_RS01785	COG0561	phosphatase activity
M5E03_RS01790	COG0673	inositol 2-dehydrogenase activity
M5E03_RS01795	COG0738	Major facilitator superfamily
M5E03_RS01800	COG1280	lysine exporter protein (LysE YggA)
M5E03_RS01810	COG3403	YqcI/YcgG family
M5E03_RS01815	COG1113	amino acid transport
M5E03_RS01820	COG3665	Urea carboxylase-associated protein
M5E03_RS01825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M5E03_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_RS01840	COG0710	3-dehydroquinate dehydratase activity
M5E03_RS01845	COG0028	Belongs to the TPP enzyme family
M5E03_RS01855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M5E03_RS01875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M5E03_RS01880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E03_RS01890	COG0477	Major facilitator Superfamily
M5E03_RS01895	COG2226	methyltransferase
M5E03_RS01900	COG0583	DNA-binding transcription factor activity
M5E03_RS01905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E03_RS01910	COG3458	cephalosporin-C deacetylase activity
M5E03_RS01920	COG3541	Predicted nucleotidyltransferase
M5E03_RS01925	COG0506	proline dehydrogenase activity
M5E03_RS01930	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_RS01935	COG2508	Transcriptional regulator
M5E03_RS01940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M5E03_RS01945	COG0765	amino acid transport
M5E03_RS01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_RS01960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5E03_RS01965	COG1522	sequence-specific DNA binding
M5E03_RS01970	COG2746	aminoglycoside 3-N-acetyltransferase activity
M5E03_RS01980	COG0840	transmembrane signaling receptor activity
M5E03_RS01980	COG3290	protein histidine kinase activity
M5E03_RS01985	COG3209	COG3209 Rhs family protein
M5E03_RS02005	COG3842	ATPase activity
M5E03_RS02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E03_RS02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E03_RS02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E03_RS02045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M5E03_RS02060	COG4555	ABC transporter
M5E03_RS02075	COG0697	spore germination
M5E03_RS02080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_RS02095	COG2364	Membrane
M5E03_RS02100	COG0737	Belongs to the 5'-nucleotidase family
M5E03_RS02105	COG3764	Sortase (surface protein transpeptidase)
M5E03_RS02110	COG2002	toxin-antitoxin pair type II binding
M5E03_RS02115	COG1126	abc transporter atp-binding protein
M5E03_RS02120	COG0765	amino acid transport
M5E03_RS02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_RS02130	COG0412	Dienelactone hydrolase
M5E03_RS02135	COG0833	amino acid
M5E03_RS02140	COG3104	oligopeptide transport
M5E03_RS02145	COG5434	Belongs to the glycosyl hydrolase 28 family
M5E03_RS02150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_RS02155	COG0456	acetyltransferase
M5E03_RS02160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_RS02165	COG0765	amino acid transport
M5E03_RS02170	COG1126	abc transporter atp-binding protein
M5E03_RS02175	COG1473	amidohydrolase
M5E03_RS02180	COG2079	MmgE PrpD family protein
M5E03_RS02185	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_RS02190	COG0527	aspartate kinase activity
M5E03_RS02195	COG2814	Major facilitator Superfamily
M5E03_RS02200	COG1309	transcriptional regulator
M5E03_RS02210	COG0640	Transcriptional regulator
M5E03_RS02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_RS02220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5E03_RS02225	COG0531	amino acid
M5E03_RS02230	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_RS02235	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5E03_RS02240	COG4549	nuclear export factor GLE1
M5E03_RS02245	COG2372	response to copper ion
M5E03_RS02245	COG1276	copper resistance
M5E03_RS02250	COG2213	PTS system mannitol-specific
M5E03_RS02255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS02260	COG0246	Mannitol dehydrogenase
M5E03_RS02265	COG0840	transmembrane signaling receptor activity
M5E03_RS02285	COG0346	lactoylglutathione lyase activity
M5E03_RS02295	COG0561	phosphatase activity
M5E03_RS02300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M5E03_RS02305	COG1914	H( )-stimulated, divalent metal cation uptake system
M5E03_RS02310	COG4336	lyase activity
M5E03_RS02315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M5E03_RS02320	COG1984	allophanate hydrolase subunit 2
M5E03_RS02325	COG1414	Transcriptional regulator
M5E03_RS02330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M5E03_RS02335	COG2755	lipolytic protein G-D-S-L family
M5E03_RS02345	COG3711	transcriptional antiterminator
M5E03_RS02350	COG2226	methyltransferase
M5E03_RS02355	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS02360	COG3871	stress protein (general stress protein 26)
M5E03_RS02380	COG2814	Major facilitator Superfamily
M5E03_RS02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5E03_RS02390	COG0551	DNA topoisomerase type I activity
M5E03_RS02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M5E03_RS02405	COG3706	GGDEF domain
M5E03_RS02410	COG5298	Protein conserved in bacteria
M5E03_RS02415	COG1215	transferase activity, transferring glycosyl groups
M5E03_RS02425	COG0531	amino acid
M5E03_RS02430	COG0028	Belongs to the TPP enzyme family
M5E03_RS02435	COG5444	nuclease activity
M5E03_RS02460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_RS02465	COG1914	H( )-stimulated, divalent metal cation uptake system
M5E03_RS02470	COG2261	transglycosylase associated protein
M5E03_RS02475	COG2217	Heavy metal translocating P-type atpase
M5E03_RS02480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M5E03_RS02485	COG3290	protein histidine kinase activity
M5E03_RS02490	COG4565	transcriptional regulatory protein
M5E03_RS02495	COG1301	dicarboxylic acid transport
M5E03_RS02500	COG0628	permease
M5E03_RS02505	COG1301	dicarboxylic acid transport
M5E03_RS02510	COG1131	(ABC) transporter
M5E03_RS02515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M5E03_RS02530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_RS02535	COG1181	Belongs to the D-alanine--D-alanine ligase family
M5E03_RS02540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M5E03_RS02555	COG0513	Belongs to the DEAD box helicase family
M5E03_RS02560	COG3402	PFAM membrane-flanked domain
M5E03_RS02565	COG3428	Bacterial PH domain
M5E03_RS02570	COG0705	Rhomboid family
M5E03_RS02575	COG0736	holo-[acyl-carrier-protein] synthase activity
M5E03_RS02580	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M5E03_RS02585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5E03_RS02590	COG0864	Transcriptional regulator
M5E03_RS02595	COG2337	Toxic component of a toxin-antitoxin (TA) module
M5E03_RS02600	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_RS02605	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_RS02610	COG2172	sigma factor antagonist activity
M5E03_RS02615	COG2208	phosphoserine phosphatase activity
M5E03_RS02620	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_RS02625	COG2172	sigma factor antagonist activity
M5E03_RS02630	COG1191	sigma factor activity
M5E03_RS02635	COG2208	phosphoserine phosphatase activity
M5E03_RS02640	COG2183	response to ionizing radiation
M5E03_RS02650	COG3091	SprT-like family
M5E03_RS02655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E03_RS02660	COG0022	dehydrogenase e1 component
M5E03_RS02665	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_RS02670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E03_RS02675	COG3284	Transcriptional regulator
M5E03_RS02720	COG1278	Cold shock
M5E03_RS02725	COG1329	Transcriptional regulator
M5E03_RS02730	COG1064	alcohol dehydrogenase
M5E03_RS02735	COG0789	Transcriptional regulator
M5E03_RS02750	COG0477	Major facilitator Superfamily
M5E03_RS02755	COG0657	acetylesterase activity
M5E03_RS02775	COG4221	oxidoreductase activity
M5E03_RS02790	COG0252	asparaginase activity
M5E03_RS02810	COG2814	Major facilitator Superfamily
M5E03_RS02815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_RS02845	COG1309	transcriptional regulator
M5E03_RS02850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5E03_RS02855	COG1846	Transcriptional regulator
M5E03_RS02860	COG0778	Nitroreductase
M5E03_RS02875	COG1396	sequence-specific DNA binding
M5E03_RS02895	COG4122	O-methyltransferase activity
M5E03_RS02905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M5E03_RS02910	COG0697	spore germination
M5E03_RS02920	COG1301	dicarboxylic acid transport
M5E03_RS02960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M5E03_RS02965	COG0802	atpase or kinase
M5E03_RS02970	COG1214	PFAM Peptidase M22, glycoprotease
M5E03_RS02975	COG0456	acetyltransferase
M5E03_RS02980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M5E03_RS02985	COG0488	(ABC) transporter
M5E03_RS02990	COG0315	cyclic pyranopterin monophosphate synthase activity
M5E03_RS02995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M5E03_RS03000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5E03_RS03005	COG0805	protein transport
M5E03_RS03020	COG1266	CAAX protease self-immunity
M5E03_RS03025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M5E03_RS03030	COG0459	protein refolding
M5E03_RS03035	COG4974	Belongs to the 'phage' integrase family
M5E03_RS03040	COG2856	Zn peptidase
M5E03_RS03050	COG1396	sequence-specific DNA binding
M5E03_RS03095	COG5377	YqaJ viral recombinase family
M5E03_RS03100	COG3723	Recombinational DNA repair protein, rece pathway
M5E03_RS03110	COG1484	DNA-dependent DNA replication
M5E03_RS03115	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
M5E03_RS03155	COG3677	Transposase
M5E03_RS03170	COG5484	DNA packaging
M5E03_RS03275	COG4824	toxin secretion phage lysis holin
M5E03_RS03280	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_RS03280	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5E03_RS03305	COG1487	ribonuclease activity
M5E03_RS03315	COG1846	Transcriptional regulator
M5E03_RS03320	COG0456	acetyltransferase
M5E03_RS03325	COG2808	Putative FMN-binding domain
M5E03_RS03345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M5E03_RS03350	COG0823	Involved in the tonB-independent uptake of proteins
M5E03_RS03360	COG2132	Multicopper oxidase
M5E03_RS03365	COG1113	amino acid transport
M5E03_RS03370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5E03_RS03375	COG0714	Associated with various cellular activities
M5E03_RS03380	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M5E03_RS03385	COG1305	Transglutaminase-like
M5E03_RS03390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5E03_RS03390	COG0519	Catalyzes the synthesis of GMP from XMP
M5E03_RS03395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M5E03_RS03405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E03_RS03410	COG2207	Transcriptional regulator
M5E03_RS03435	COG1404	Belongs to the peptidase S8 family
M5E03_RS03455	COG1595	DNA-templated transcription, initiation
M5E03_RS03465	COG2814	Major facilitator Superfamily
M5E03_RS03470	COG0583	DNA-binding transcription factor activity
M5E03_RS03475	COG2252	PERMEase
M5E03_RS03490	COG3064	Membrane
M5E03_RS03495	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M5E03_RS03505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M5E03_RS03510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M5E03_RS03515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M5E03_RS03520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5E03_RS03525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5E03_RS03530	COG0047	phosphoribosylformylglycinamidine synthase activity
M5E03_RS03535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5E03_RS03540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M5E03_RS03545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M5E03_RS03550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M5E03_RS03555	COG0138	bifunctional purine biosynthesis protein purh
M5E03_RS03560	COG0151	Belongs to the GarS family
M5E03_RS03580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5E03_RS03585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5E03_RS03590	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E03_RS03595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5E03_RS03605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M5E03_RS03610	COG4496	protein, YerC YecD
M5E03_RS03615	COG0069	glutamate synthase activity
M5E03_RS03630	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M5E03_RS03635	COG0210	DNA helicase
M5E03_RS03640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5E03_RS03645	COG4851	CamS sex pheromone cAM373 precursor
M5E03_RS03650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E03_RS03655	COG1285	pathogenesis
M5E03_RS03660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E03_RS03665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E03_RS03670	COG0154	amidase activity
M5E03_RS03675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E03_RS03680	COG1309	transcriptional regulator
M5E03_RS03685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E03_RS03690	COG1957	nucleoside hydrolase
M5E03_RS03695	COG1597	lipid kinase activity
M5E03_RS03700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5E03_RS03730	COG0457	Tetratricopeptide repeat
M5E03_RS03735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E03_RS03745	COG1737	Transcriptional regulator
M5E03_RS03750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS03750	COG1263	PTS System
M5E03_RS03755	COG1486	melibiose metabolic process
M5E03_RS03765	COG1959	2 iron, 2 sulfur cluster binding
M5E03_RS03770	COG0492	ferredoxin-NADP+ reductase activity
M5E03_RS03785	COG1486	melibiose metabolic process
M5E03_RS03795	COG2211	Major facilitator Superfamily
M5E03_RS03825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M5E03_RS03830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E03_RS03835	COG1442	glycosyl transferase family 8
M5E03_RS03840	COG1216	Glycosyl transferase, family 2
M5E03_RS03845	COG1442	glycosyl transferase family 8
M5E03_RS03850	COG2223	nitrite transmembrane transporter activity
M5E03_RS03870	COG0693	protein deglycase activity
M5E03_RS03885	COG0071	Belongs to the small heat shock protein (HSP20) family
M5E03_RS03900	COG0531	amino acid
M5E03_RS03905	COG0457	Tetratricopeptide repeat
M5E03_RS03905	COG0463	Glycosyl transferase, family 2
M5E03_RS03910	COG0488	(ABC) transporter
M5E03_RS03915	COG1469	GTP cyclohydrolase I activity
M5E03_RS03920	COG0789	Transcriptional regulator
M5E03_RS03925	COG2814	Major facilitator Superfamily
M5E03_RS03930	COG0488	(ABC) transporter
M5E03_RS03935	COG0513	Belongs to the DEAD box helicase family
M5E03_RS03940	COG2130	NADP-dependent
M5E03_RS03960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E03_RS03960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E03_RS03965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M5E03_RS03975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E03_RS03975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E03_RS03985	COG3290	protein histidine kinase activity
M5E03_RS03990	COG4565	transcriptional regulatory protein
M5E03_RS03995	COG3181	Tripartite tricarboxylate transporter family receptor
M5E03_RS04000	COG2851	Citrate transporter
M5E03_RS04010	COG3479	Phenolic acid decarboxylase
M5E03_RS04015	COG1695	Transcriptional regulator
M5E03_RS04020	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M5E03_RS04025	COG0477	Major facilitator Superfamily
M5E03_RS04030	COG0583	DNA-binding transcription factor activity
M5E03_RS04035	COG1254	Belongs to the acylphosphatase family
M5E03_RS04040	COG2258	MOSC domain
M5E03_RS04055	COG0024	Methionine aminopeptidase
M5E03_RS04060	COG1263	PTS System
M5E03_RS04060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS04065	COG3739	integral membrane protein
M5E03_RS04080	COG1368	sulfuric ester hydrolase activity
M5E03_RS04085	COG0076	glutamate decarboxylase activity
M5E03_RS04100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS04100	COG1263	PTS System
M5E03_RS04105	COG0366	Alpha amylase catalytic
M5E03_RS04110	COG2188	Transcriptional regulator
M5E03_RS04120	COG0737	Belongs to the 5'-nucleotidase family
M5E03_RS04125	COG0693	protein deglycase activity
M5E03_RS04130	COG4840	Belongs to the UPF0435 family
M5E03_RS04135	COG1115	amino acid carrier protein
M5E03_RS04140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5E03_RS04145	COG4980	gas vesicle protein
M5E03_RS04150	COG1295	ribonuclease BN
M5E03_RS04165	COG0477	Major facilitator Superfamily
M5E03_RS04175	COG0387	Pfam Sodium calcium exchanger
M5E03_RS04185	COG0217	transcriptional regulatory protein
M5E03_RS04190	COG0668	transmembrane transport
M5E03_RS04195	COG0535	radical SAM domain protein
M5E03_RS04205	COG0726	polysaccharide deacetylase
M5E03_RS04210	COG0598	Magnesium transport protein CorA
M5E03_RS04220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M5E03_RS04225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5E03_RS04240	COG0583	DNA-binding transcription factor activity
M5E03_RS04245	COG1942	4-Oxalocrotonate Tautomerase
M5E03_RS04250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E03_RS04255	COG0789	Transcriptional regulator
M5E03_RS04260	COG2814	Major facilitator Superfamily
M5E03_RS04315	COG2076	Multidrug Resistance protein
M5E03_RS04320	COG2076	Multidrug Resistance protein
M5E03_RS04325	COG1309	transcriptional regulator
M5E03_RS04335	COG4637	Psort location Cytoplasmic, score
M5E03_RS04340	COG2755	lipolytic protein G-D-S-L family
M5E03_RS04345	COG0492	ferredoxin-NADP+ reductase activity
M5E03_RS04350	COG1742	UPF0060 membrane protein
M5E03_RS04355	COG1595	DNA-templated transcription, initiation
M5E03_RS04375	COG2318	DinB family
M5E03_RS04385	COG1846	Transcriptional regulator
M5E03_RS04390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M5E03_RS04390	COG0392	lysyltransferase activity
M5E03_RS04410	COG0778	Nitroreductase
M5E03_RS04425	COG1090	epimerase
M5E03_RS04430	COG2137	regulation of response to DNA damage stimulus
M5E03_RS04455	COG0463	Glycosyl transferase, family 2
M5E03_RS04460	COG4485	Bacterial membrane protein, YfhO
M5E03_RS04465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5E03_RS04480	COG2140	Oxalate decarboxylase
M5E03_RS04490	COG1191	sigma factor activity
M5E03_RS04535	COG1988	membrane-bound metal-dependent
M5E03_RS04540	COG1194	a g-specific adenine glycosylase
M5E03_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS04565	COG3557	Belongs to the UPF0374 family
M5E03_RS04570	COG1132	(ABC) transporter
M5E03_RS04575	COG0444	Belongs to the ABC transporter superfamily
M5E03_RS04580	COG4608	Belongs to the ABC transporter superfamily
M5E03_RS04585	COG0747	negative chemotaxis
M5E03_RS04590	COG0601	transmembrane transport
M5E03_RS04595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_RS04600	COG4129	membrane
M5E03_RS04605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M5E03_RS04610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5E03_RS04615	COG0735	belongs to the Fur family
M5E03_RS04760	COG1368	sulfuric ester hydrolase activity
M5E03_RS04765	COG0681	Belongs to the peptidase S26 family
M5E03_RS04770	COG2873	o-acetylhomoserine
M5E03_RS04780	COG1116	anion transmembrane transporter activity
M5E03_RS04785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E03_RS04790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5E03_RS04805	COG1131	(ABC) transporter
M5E03_RS04835	COG3382	B3 4 domain protein
M5E03_RS04840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M5E03_RS04850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M5E03_RS04860	COG2766	serine protein kinase
M5E03_RS04865	COG2718	Belongs to the UPF0229 family
M5E03_RS04870	COG1566	PFAM secretion protein HlyD family protein
M5E03_RS04875	COG2814	Major facilitator Superfamily
M5E03_RS04880	COG0655	NAD(P)H dehydrogenase (quinone) activity
M5E03_RS04890	COG1278	Cold shock
M5E03_RS04895	COG3706	GGDEF domain
M5E03_RS04920	COG5577	PFAM Coat F domain
M5E03_RS04925	COG5002	protein histidine kinase activity
M5E03_RS04930	COG0737	Belongs to the 5'-nucleotidase family
M5E03_RS04930	COG4085	toxin activity
M5E03_RS04930	COG1525	nuclease
M5E03_RS04935	COG3764	Sortase (surface protein transpeptidase)
M5E03_RS04940	COG0564	pseudouridine synthase activity
M5E03_RS04950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5E03_RS04955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E03_RS04955	COG3153	acetyltransferase
M5E03_RS04970	COG3835	regulator
M5E03_RS04975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5E03_RS04980	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M5E03_RS04985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5E03_RS04990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M5E03_RS04995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M5E03_RS05000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E03_RS05005	COG4585	Histidine kinase
M5E03_RS05005	COG2203	Gaf domain
M5E03_RS05010	COG2197	response regulator
M5E03_RS05025	COG0753	catalase activity
M5E03_RS05030	COG1959	2 iron, 2 sulfur cluster binding
M5E03_RS05035	COG1017	nitric oxide dioxygenase activity
M5E03_RS05035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5E03_RS05040	COG2719	SpoVR family
M5E03_RS05045	COG2721	sulfolactate sulfo-lyase activity
M5E03_RS05050	COG2186	Transcriptional regulator
M5E03_RS05055	COG4948	Mandelate Racemase Muconate Lactonizing
M5E03_RS05060	COG2271	Major facilitator Superfamily
M5E03_RS05065	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_RS05070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E03_RS05075	COG1785	Belongs to the alkaline phosphatase family
M5E03_RS05080	COG0791	NLP P60 protein
M5E03_RS05080	COG1388	LysM domain
M5E03_RS05085	COG0531	amino acid
M5E03_RS05100	COG1595	DNA-templated transcription, initiation
M5E03_RS05105	COG0204	Acyl-transferase
M5E03_RS05110	COG1253	flavin adenine dinucleotide binding
M5E03_RS05115	COG0789	Transcriptional regulator
M5E03_RS05120	COG1253	flavin adenine dinucleotide binding
M5E03_RS05130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5E03_RS05135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5E03_RS05140	COG0584	glycerophosphoryl diester phosphodiesterase
M5E03_RS05150	COG0668	transmembrane transport
M5E03_RS05155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5E03_RS05160	COG0726	polysaccharide deacetylase
M5E03_RS05165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E03_RS05170	COG0589	response to stress
M5E03_RS05175	COG1132	(ABC) transporter
M5E03_RS05180	COG1132	(ABC) transporter
M5E03_RS05185	COG0702	epimerase
M5E03_RS05195	COG3842	ATPase activity
M5E03_RS05200	COG2508	Transcriptional regulator
M5E03_RS05210	COG0189	ligase activity
M5E03_RS05215	COG0189	ligase activity
M5E03_RS05220	COG4399	Belongs to the UPF0754 family
M5E03_RS05225	COG3679	Belongs to the UPF0342 family
M5E03_RS05230	COG0561	phosphatase activity
M5E03_RS05235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E03_RS05245	COG0475	glutathione-regulated potassium exporter activity
M5E03_RS05250	COG0490	domain, Protein
M5E03_RS05260	COG1024	Enoyl-CoA hydratase
M5E03_RS05270	COG0420	3'-5' exonuclease activity
M5E03_RS05275	COG4717	serine-type aminopeptidase activity
M5E03_RS05280	COG3481	metal-dependent phosphohydrolase, HD sub domain
M5E03_RS05290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E03_RS05320	COG1846	Transcriptional regulator
M5E03_RS05325	COG4980	gas vesicle protein
M5E03_RS05340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M5E03_RS05345	COG0537	adenosine 5'-monophosphoramidase activity
M5E03_RS05350	COG1131	(ABC) transporter
M5E03_RS05355	COG4473	ABC transporter
M5E03_RS05365	COG1473	amidohydrolase
M5E03_RS05375	COG2329	Antibiotic biosynthesis monooxygenase
M5E03_RS05380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E03_RS05385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M5E03_RS05390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M5E03_RS05395	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M5E03_RS05400	COG1309	transcriptional regulator
M5E03_RS05405	COG1511	domain protein
M5E03_RS05410	COG1363	Peptidase, m42
M5E03_RS05415	COG1301	dicarboxylic acid transport
M5E03_RS05425	COG1234	tRNA 3'-trailer cleavage
M5E03_RS05430	COG0095	Lipoate-protein ligase
M5E03_RS05435	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_RS05445	COG0501	Belongs to the peptidase M48B family
M5E03_RS05450	COG1404	Belongs to the peptidase S8 family
M5E03_RS05455	COG0406	alpha-ribazole phosphatase activity
M5E03_RS05460	COG0840	transmembrane signaling receptor activity
M5E03_RS05465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5E03_RS05465	COG0723	plastoquinol--plastocyanin reductase activity
M5E03_RS05470	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS05480	COG4903	ComK protein
M5E03_RS05490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_RS05495	COG2814	Major facilitator Superfamily
M5E03_RS05500	COG2732	(Barnase) inhibitor
M5E03_RS05505	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_RS05510	COG4605	iron ion homeostasis
M5E03_RS05515	COG4604	ABC transporter, ATP-binding protein
M5E03_RS05520	COG4607	ABC-type enterochelin transport system periplasmic component
M5E03_RS05525	COG1316	TRANSCRIPTIONal
M5E03_RS05535	COG0398	Pfam SNARE associated Golgi protein
M5E03_RS05540	COG0681	Belongs to the peptidase S26 family
M5E03_RS05545	COG3180	Ammonia monooxygenase
M5E03_RS05555	COG0501	Belongs to the peptidase M48B family
M5E03_RS05560	COG2259	Doxx family
M5E03_RS05565	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M5E03_RS05570	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M5E03_RS05575	COG1074	ATP-dependent DNA helicase activity
M5E03_RS05580	COG0420	3'-5' exonuclease activity
M5E03_RS05585	COG0419	ATPase involved in DNA repair
M5E03_RS05590	COG1403	HNH endonuclease
M5E03_RS05630	COG5337	Spore coat protein CotH
M5E03_RS05635	COG0179	Fumarylacetoacetate (FAA) hydrolase
M5E03_RS05650	COG0367	asparagine synthase
M5E03_RS05665	COG1562	ergosterol biosynthetic process
M5E03_RS05670	COG0534	Mate efflux family protein
M5E03_RS05675	COG1917	Cupin 2, conserved barrel domain protein
M5E03_RS05675	COG2207	Transcriptional regulator
M5E03_RS05700	COG0076	glutamate decarboxylase activity
M5E03_RS05730	COG0646	methionine synthase
M5E03_RS05730	COG1410	methionine synthase
M5E03_RS05735	COG0646	methionine synthase
M5E03_RS05735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M5E03_RS05740	COG1666	GTP binding
M5E03_RS05745	COG2996	Protein conserved in bacteria
M5E03_RS05750	COG1744	ABC transporter substrate-binding protein PnrA-like
M5E03_RS05755	COG0840	transmembrane signaling receptor activity
M5E03_RS05760	COG1307	EDD domain protein, DegV family
M5E03_RS05765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_RS05785	COG0561	phosphatase activity
M5E03_RS05790	COG1073	alpha beta
M5E03_RS05795	COG2151	metal-sulfur cluster biosynthetic enzyme
M5E03_RS05800	COG0277	FAD linked oxidase domain protein
M5E03_RS05805	COG2271	Major facilitator Superfamily
M5E03_RS05810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M5E03_RS05815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M5E03_RS05820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5E03_RS05825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E03_RS05830	COG0505	Belongs to the CarA family
M5E03_RS05835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5E03_RS05840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M5E03_RS05850	COG2814	Major facilitator Superfamily
M5E03_RS05860	COG2267	carboxylic ester hydrolase activity
M5E03_RS05870	COG1744	ABC transporter substrate-binding protein PnrA-like
M5E03_RS05885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5E03_RS05890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5E03_RS05895	COG5504	Zn-dependent protease
M5E03_RS05900	COG0444	Belongs to the ABC transporter superfamily
M5E03_RS05905	COG4608	Belongs to the ABC transporter superfamily
M5E03_RS05915	COG0601	transmembrane transport
M5E03_RS05920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_RS05930	COG0180	Tryptophanyl-tRNA synthetase
M5E03_RS05935	COG4166	transmembrane transport
M5E03_RS05940	COG0601	transmembrane transport
M5E03_RS05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_RS05950	COG0444	Belongs to the ABC transporter superfamily
M5E03_RS05955	COG4608	Belongs to the ABC transporter superfamily
M5E03_RS05965	COG0456	acetyltransferase
M5E03_RS05970	COG1393	Belongs to the ArsC family
M5E03_RS05975	COG0861	Integral membrane protein TerC family
M5E03_RS05980	COG4862	establishment of competence for transformation
M5E03_RS05985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E03_RS05995	COG1164	Oligoendopeptidase f
M5E03_RS06005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M5E03_RS06010	COG2346	COG2346, Truncated hemoglobins
M5E03_RS06015	COG0741	lytic transglycosylase activity
M5E03_RS06020	COG4116	CYTH
M5E03_RS06030	COG2357	RelA SpoT domain protein
M5E03_RS06035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5E03_RS06040	COG0564	pseudouridine synthase activity
M5E03_RS06045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M5E03_RS06050	COG0475	glutathione-regulated potassium exporter activity
M5E03_RS06050	COG0569	domain protein
M5E03_RS06055	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E03_RS06060	COG0352	thiamine-phosphate diphosphorylase activity
M5E03_RS06070	COG2104	thiamine diphosphate biosynthetic process
M5E03_RS06075	COG2022	thiamine diphosphate biosynthetic process
M5E03_RS06080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5E03_RS06085	COG0351	phosphomethylpyrimidine kinase
M5E03_RS06090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M5E03_RS06145	COG0210	DNA helicase
M5E03_RS06160	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M5E03_RS06165	COG2382	esterase
M5E03_RS06170	COG0626	cystathionine gamma-synthase activity
M5E03_RS06175	COG0626	cystathionine gamma-synthase activity
M5E03_RS06185	COG1280	lysine exporter protein (LysE YggA)
M5E03_RS06190	COG0825	malonyl-CoA metabolic process
M5E03_RS06210	COG0457	Tetratricopeptide repeat
M5E03_RS06235	COG3173	Aminoglycoside phosphotransferase
M5E03_RS06240	COG0583	DNA-binding transcription factor activity
M5E03_RS06260	COG0583	DNA-binding transcription factor activity
M5E03_RS06265	COG2807	transmembrane transport
M5E03_RS06275	COG0457	Tetratricopeptide repeat
M5E03_RS06295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5E03_RS06305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E03_RS06310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E03_RS06315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E03_RS06335	COG4195	phage-related replication protein
M5E03_RS06340	COG2856	Zn peptidase
M5E03_RS06345	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5E03_RS06345	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_RS06360	COG0306	phosphate transporter
M5E03_RS06365	COG1392	Phosphate transport regulator
M5E03_RS06375	COG0405	Gamma-glutamyltransferase
M5E03_RS06380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M5E03_RS06390	COG4208	sulfate ABC transporter
M5E03_RS06395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M5E03_RS06405	COG3775	system Galactitol-specific IIC component
M5E03_RS06425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E03_RS06430	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_RS06430	COG0022	dehydrogenase e1 component
M5E03_RS06435	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_RS06440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E03_RS06445	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS06455	COG2390	Transcriptional regulator
M5E03_RS06465	COG0531	amino acid
M5E03_RS06470	COG0346	lactoylglutathione lyase activity
M5E03_RS06475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E03_RS06480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5E03_RS06485	COG2362	D-Aminopeptidase
M5E03_RS06490	COG0601	transmembrane transport
M5E03_RS06495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_RS06500	COG0444	Belongs to the ABC transporter superfamily
M5E03_RS06505	COG4166	transmembrane transport
M5E03_RS06510	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5E03_RS06515	COG4948	Mandelate Racemase Muconate Lactonizing
M5E03_RS06520	COG0791	NLP P60 protein
M5E03_RS06525	COG4608	Belongs to the ABC transporter superfamily
M5E03_RS06530	COG1834	amidinotransferase
M5E03_RS06535	COG1607	acyl-coa hydrolase
M5E03_RS06540	COG1695	Transcriptional regulator
M5E03_RS06555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_RS06570	COG2076	Multidrug Resistance protein
M5E03_RS06575	COG2076	Multidrug Resistance protein
M5E03_RS06585	COG0788	formyltetrahydrofolate deformylase activity
M5E03_RS06590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5E03_RS06595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M5E03_RS06600	COG0457	Tetratricopeptide repeat
M5E03_RS06610	COG1764	response to oxidative stress
M5E03_RS06615	COG1846	Transcriptional regulator
M5E03_RS06620	COG1764	response to oxidative stress
M5E03_RS06625	COG0590	tRNA wobble adenosine to inosine editing
M5E03_RS06630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5E03_RS06635	COG1404	Belongs to the peptidase S8 family
M5E03_RS06640	COG0745	RESPONSE REGULATOR receiver
M5E03_RS06645	COG3850	Histidine kinase
M5E03_RS06645	COG5002	protein histidine kinase activity
M5E03_RS06650	COG3212	peptidase
M5E03_RS06655	COG3212	peptidase
M5E03_RS06665	COG2239	Acts as a magnesium transporter
M5E03_RS06675	COG0789	Transcriptional regulator
M5E03_RS06690	COG1846	Transcriptional regulator
M5E03_RS06695	COG3300	MHYT domain
M5E03_RS06695	COG5001	Diguanylate cyclase
M5E03_RS06700	COG0586	Pfam SNARE associated Golgi protein
M5E03_RS06710	COG1191	sigma factor activity
M5E03_RS06730	COG0501	Belongs to the peptidase M48B family
M5E03_RS06735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5E03_RS06740	COG2323	membrane
M5E03_RS06755	COG3594	Acyltransferase
M5E03_RS06760	COG5002	protein histidine kinase activity
M5E03_RS06765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M5E03_RS06775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M5E03_RS06780	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
M5E03_RS06785	COG0436	Aminotransferase
M5E03_RS06790	COG1850	ribulose-bisphosphate carboxylase activity
M5E03_RS06795	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
M5E03_RS06800	COG0235	Class ii aldolase
M5E03_RS06805	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M5E03_RS06815	COG3852	Histidine kinase
M5E03_RS06820	COG1846	Transcriptional regulator
M5E03_RS06825	COG1360	Flagellar Motor Protein
M5E03_RS06830	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M5E03_RS06835	COG0542	response to heat
M5E03_RS06840	COG3949	Membrane
M5E03_RS06845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M5E03_RS06850	COG0720	synthase
M5E03_RS06855	COG0602	queuosine metabolic process
M5E03_RS06860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M5E03_RS06865	COG1733	regulation of RNA biosynthetic process
M5E03_RS06870	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS06885	COG4873	Protein conserved in bacteria
M5E03_RS06895	COG3773	Cell wall hydrolase
M5E03_RS06900	COG2244	polysaccharide biosynthetic process
M5E03_RS06905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_RS06910	COG2217	Heavy metal translocating P-type atpase
M5E03_RS06915	COG0006	proline dipeptidase activity
M5E03_RS06925	COG1609	Transcriptional regulator
M5E03_RS06930	COG3711	transcriptional antiterminator
M5E03_RS06935	COG1263	PTS System
M5E03_RS06935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS06935	COG2190	(PTS) system
M5E03_RS06940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS06945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5E03_RS06955	COG1533	DNA photolyase activity
M5E03_RS06960	COG0840	transmembrane signaling receptor activity
M5E03_RS06970	COG2084	Dehydrogenase
M5E03_RS06975	COG2340	Cysteine-rich secretory protein family
M5E03_RS06980	COG0768	penicillin binding
M5E03_RS06985	COG4191	Histidine kinase
M5E03_RS06990	COG0436	Aminotransferase
M5E03_RS06995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5E03_RS07005	COG1714	RDD family
M5E03_RS07015	COG0835	chemotaxis
M5E03_RS07015	COG0784	Response regulator, receiver
M5E03_RS07030	COG1917	Cupin 2, conserved barrel domain protein
M5E03_RS07030	COG2207	Transcriptional regulator
M5E03_RS07035	COG0697	spore germination
M5E03_RS07045	COG2814	Major facilitator Superfamily
M5E03_RS07050	COG1376	ErfK ybiS ycfS ynhG family protein
M5E03_RS07055	COG1408	metallophosphoesterase
M5E03_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS07065	COG2200	EAL domain
M5E03_RS07070	COG3546	catalase activity
M5E03_RS07075	COG4703	Protein of unknown function (DUF1797)
M5E03_RS07080	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M5E03_RS07090	COG0517	IMP dehydrogenase activity
M5E03_RS07095	COG0583	DNA-binding transcription factor activity
M5E03_RS07100	COG0716	FMN binding
M5E03_RS07110	COG0716	FMN binding
M5E03_RS07115	COG2171	N-acyltransferase activity
M5E03_RS07120	COG1473	amidohydrolase
M5E03_RS07130	COG0668	transmembrane transport
M5E03_RS07135	COG0450	alkyl hydroperoxide reductase
M5E03_RS07140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_RS07155	COG0746	molybdenum cofactor guanylyltransferase activity
M5E03_RS07160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5E03_RS07165	COG0303	'Molybdopterin
M5E03_RS07170	COG1763	Mo-molybdopterin cofactor biosynthetic process
M5E03_RS07175	COG0314	molybdopterin synthase activity
M5E03_RS07180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M5E03_RS07195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E03_RS07200	COG1136	(ABC) transporter
M5E03_RS07205	COG0577	efflux transmembrane transporter activity
M5E03_RS07210	COG1349	DNA-binding transcription factor activity
M5E03_RS07215	COG1105	Belongs to the carbohydrate kinase PfkB family
M5E03_RS07220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_RS07220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS07220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_RS07235	COG0488	(ABC) transporter
M5E03_RS07240	COG2309	aminopeptidase activity
M5E03_RS07250	COG1077	Cell shape determining protein MreB Mrl
M5E03_RS07255	COG2002	toxin-antitoxin pair type II binding
M5E03_RS07260	COG3852	Histidine kinase
M5E03_RS07265	COG2105	PFAM AIG2 family protein
M5E03_RS07265	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M5E03_RS07270	COG0569	domain protein
M5E03_RS07275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M5E03_RS07280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5E03_RS07285	COG5503	Protein of unknown function (DUF1447)
M5E03_RS07290	COG0561	phosphatase activity
M5E03_RS07295	COG0242	peptide deformylase activity
M5E03_RS07310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E03_RS07315	COG0022	dehydrogenase e1 component
M5E03_RS07320	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_RS07325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E03_RS07330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_RS07340	COG1982	Orn Lys Arg decarboxylase major
M5E03_RS07345	COG4476	Belongs to the UPF0223 family
M5E03_RS07350	COG4493	Belongs to the UPF0637 family
M5E03_RS07360	COG0483	inositol monophosphate 1-phosphatase activity
M5E03_RS07375	COG1595	DNA-templated transcription, initiation
M5E03_RS07395	COG1217	gtp-binding protein TYPA
M5E03_RS07405	COG4896	Protein conserved in bacteria
M5E03_RS07415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M5E03_RS07420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M5E03_RS07425	COG2066	Belongs to the glutaminase family
M5E03_RS07430	COG4838	Belongs to the UPF0358 family
M5E03_RS07435	COG0772	Belongs to the SEDS family
M5E03_RS07440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M5E03_RS07445	COG0415	Belongs to the DNA photolyase family
M5E03_RS07450	COG1612	heme a metabolic process
M5E03_RS07455	COG0109	protoheme IX farnesyltransferase activity
M5E03_RS07460	COG2010	Cytochrome c
M5E03_RS07460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5E03_RS07465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5E03_RS07470	COG1845	cytochrome c oxidase, subunit III
M5E03_RS07475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5E03_RS07480	COG3336	cytochrome c oxidase
M5E03_RS07490	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M5E03_RS07495	COG2340	Cysteine-rich secretory protein family
M5E03_RS07515	COG3679	Belongs to the UPF0342 family
M5E03_RS07520	COG4471	UPF0298 protein
M5E03_RS07525	COG0742	ribosomal rna small subunit methyltransferase
M5E03_RS07530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M5E03_RS07535	COG3314	Sporulation integral membrane protein YlbJ
M5E03_RS07540	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E03_RS07545	COG3480	Lon protease (S16) C-terminal proteolytic domain
M5E03_RS07555	COG1399	metal-binding, possibly nucleic acid-binding protein
M5E03_RS07560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M5E03_RS07570	COG0454	-acetyltransferase
M5E03_RS07575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M5E03_RS07580	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M5E03_RS07585	COG2001	Belongs to the MraZ family
M5E03_RS07590	COG0275	rRNA processing
M5E03_RS07595	COG4839	cell division protein FtsL
M5E03_RS07600	COG0768	penicillin binding
M5E03_RS07605	COG0768	penicillin binding
M5E03_RS07615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5E03_RS07620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M5E03_RS07625	COG0772	Belongs to the SEDS family
M5E03_RS07630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5E03_RS07635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M5E03_RS07640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M5E03_RS07645	COG3879	Bacterial protein of unknown function (DUF881)
M5E03_RS07650	COG3879	Bacterial protein of unknown function (DUF881)
M5E03_RS07655	COG3856	small basic protein
M5E03_RS07660	COG0849	cell division
M5E03_RS07665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M5E03_RS07670	COG1404	Belongs to the peptidase S8 family
M5E03_RS07670	COG4412	M6 family metalloprotease domain protein
M5E03_RS07680	COG1191	sigma factor activity
M5E03_RS07685	COG1191	sigma factor activity
M5E03_RS07690	COG2390	Transcriptional regulator
M5E03_RS07705	COG3730	PTS system glucitol sorbitol-specific
M5E03_RS07710	COG3732	PTS system glucitol sorbitol-specific
M5E03_RS07720	COG1119	ATPase activity
M5E03_RS07725	COG1873	PFAM PRC-barrel domain
M5E03_RS07730	COG1496	oxidoreductase activity
M5E03_RS07735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M5E03_RS07740	COG1799	cell septum assembly
M5E03_RS07745	COG0762	integral membrane protein
M5E03_RS07750	COG2302	S4 RNA-binding domain
M5E03_RS07755	COG3599	regulation of cell shape
M5E03_RS07760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5E03_RS07765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E03_RS07770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M5E03_RS07775	COG0564	pseudouridine synthase activity
M5E03_RS07780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M5E03_RS07785	COG2233	PERMEase
M5E03_RS07790	COG0540	Belongs to the ATCase OTCase family
M5E03_RS07795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M5E03_RS07800	COG0505	Belongs to the CarA family
M5E03_RS07805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5E03_RS07810	COG0543	2 iron, 2 sulfur cluster binding
M5E03_RS07815	COG0167	dihydroorotate dehydrogenase activity
M5E03_RS07820	COG0284	orotidine-5'-phosphate decarboxylase activity
M5E03_RS07825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M5E03_RS07835	COG0175	sulfate reduction
M5E03_RS07840	COG0306	phosphate transporter
M5E03_RS07845	COG2046	Belongs to the sulfate adenylyltransferase family
M5E03_RS07850	COG0529	Catalyzes the synthesis of activated sulfate
M5E03_RS07855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M5E03_RS07860	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M5E03_RS07865	COG1648	precorrin-2 dehydrogenase activity
M5E03_RS07875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M5E03_RS07880	COG1561	YicC-like family, N-terminal region
M5E03_RS07885	COG2052	Domain of unknown function (DUF370)
M5E03_RS07890	COG0194	GDP metabolic process
M5E03_RS07895	COG1758	RNA polymerase activity
M5E03_RS07900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5E03_RS07905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5E03_RS07910	COG0242	peptide deformylase activity
M5E03_RS07915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M5E03_RS07920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5E03_RS07920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5E03_RS07925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M5E03_RS07930	COG0631	protein serine/threonine phosphatase activity
M5E03_RS07935	COG2815	serine threonine protein kinase
M5E03_RS07935	COG0515	serine threonine protein kinase
M5E03_RS07940	COG1162	GTPase activity
M5E03_RS07945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E03_RS07950	COG1564	THIamine pyrophosphokinase
M5E03_RS07960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M5E03_RS07965	COG1302	Protein conserved in bacteria
M5E03_RS07970	COG1461	Dihydroxyacetone kinase
M5E03_RS07975	COG1760	l-serine dehydratase
M5E03_RS07980	COG1760	l-serine dehydratase
M5E03_RS07985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5E03_RS07990	COG1349	DNA-binding transcription factor activity
M5E03_RS07995	COG0416	fatty acid biosynthetic process
M5E03_RS08000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M5E03_RS08005	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS08010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E03_RS08020	COG1196	nuclear chromosome segregation
M5E03_RS08025	COG0552	protein localization to endoplasmic reticulum
M5E03_RS08030	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M5E03_RS08035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M5E03_RS08040	COG0228	four-way junction DNA binding
M5E03_RS08045	COG1837	Belongs to the UPF0109 family
M5E03_RS08055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M5E03_RS08060	COG0336	Belongs to the RNA methyltransferase TrmD family
M5E03_RS08065	COG0335	large ribosomal subunit rRNA binding
M5E03_RS08070	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5E03_RS08075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5E03_RS08085	COG2257	FlhB HrpN YscU SpaS Family
M5E03_RS08090	COG0045	succinate-CoA ligase (ADP-forming) activity
M5E03_RS08095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M5E03_RS08100	COG0758	DNA mediated transformation
M5E03_RS08105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5E03_RS08110	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M5E03_RS08115	COG4974	Belongs to the 'phage' integrase family
M5E03_RS08120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M5E03_RS08125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M5E03_RS08130	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M5E03_RS08135	COG1815	bacterial-type flagellum-dependent cell motility
M5E03_RS08140	COG1558	bacterial-type flagellum-dependent cell motility
M5E03_RS08145	COG1677	Flagellar hook-basal body complex protein FliE
M5E03_RS08150	COG1766	The M ring may be actively involved in energy transduction
M5E03_RS08155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5E03_RS08160	COG1317	bacterial-type flagellum organization
M5E03_RS08165	COG1157	protein secretion by the type III secretion system
M5E03_RS08170	COG2882	bacterial-type flagellum organization
M5E03_RS08175	COG3334	PFAM MgtE intracellular
M5E03_RS08180	COG3144	bacterial-type flagellum assembly
M5E03_RS08185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M5E03_RS08190	COG4786	Flagellar basal body rod
M5E03_RS08195	COG1582	Flagellar protein (FlbD)
M5E03_RS08200	COG1580	Controls the rotational direction of flagella during chemotaxis
M5E03_RS08205	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5E03_RS08210	COG1776	CheC inhibitor of MCP methylation
M5E03_RS08210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5E03_RS08215	COG2201	protein-glutamate methylesterase activity
M5E03_RS08220	COG3190	flagellar
M5E03_RS08225	COG1338	Plays a role in the flagellum-specific transport system
M5E03_RS08230	COG1987	bacterial-type flagellum assembly
M5E03_RS08235	COG1684	flagellar biosynthetic protein fliR
M5E03_RS08240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5E03_RS08245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5E03_RS08250	COG1419	protein localization to endoplasmic reticulum
M5E03_RS08255	COG0455	bacterial-type flagellum organization
M5E03_RS08260	COG2201	protein-glutamate methylesterase activity
M5E03_RS08265	COG0643	Histidine kinase
M5E03_RS08265	COG2198	Histidine kinase
M5E03_RS08270	COG0835	chemotaxis
M5E03_RS08275	COG1776	CheC inhibitor of MCP methylation
M5E03_RS08285	COG1191	sigma factor activity
M5E03_RS08300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M5E03_RS08305	COG0528	UMP kinase activity
M5E03_RS08310	COG0233	cytoplasmic translational termination
M5E03_RS08315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5E03_RS08320	COG4589	Belongs to the CDS family
M5E03_RS08325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M5E03_RS08330	COG0750	zinc metalloprotease
M5E03_RS08335	COG0442	prolyl-tRNA aminoacylation
M5E03_RS08340	COG2176	DNA-directed DNA polymerase activity
M5E03_RS08355	COG3693	PFAM glycoside hydrolase, family 10
M5E03_RS08375	COG1131	(ABC) transporter
M5E03_RS08425	COG0779	Required for maturation of 30S ribosomal subunits
M5E03_RS08430	COG0195	Participates in both transcription termination and antitermination
M5E03_RS08435	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M5E03_RS08440	COG1358	cellular component organization or biogenesis
M5E03_RS08445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M5E03_RS08450	COG1550	Protein conserved in bacteria
M5E03_RS08455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M5E03_RS08460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M5E03_RS08465	COG0196	riboflavin kinase activity
M5E03_RS08470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M5E03_RS08475	COG1185	polyribonucleotide nucleotidyltransferase activity
M5E03_RS08480	COG0726	polysaccharide deacetylase
M5E03_RS08485	COG0612	Peptidase, M16
M5E03_RS08495	COG1873	PFAM PRC-barrel domain
M5E03_RS08500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E03_RS08505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5E03_RS08510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M5E03_RS08515	COG0527	aspartate kinase activity
M5E03_RS08525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5E03_RS08530	COG0740	serine-type endopeptidase activity
M5E03_RS08540	COG1674	ftsk spoiiie
M5E03_RS08540	COG4980	gas vesicle protein
M5E03_RS08545	COG2188	Transcriptional regulator
M5E03_RS08550	COG2814	Major facilitator Superfamily
M5E03_RS08555	COG1033	growth of symbiont in host cell
M5E03_RS08555	COG2409	Drug exporters of the RND superfamily
M5E03_RS08560	COG0612	Peptidase, M16
M5E03_RS08565	COG0612	Peptidase, M16
M5E03_RS08575	COG1033	growth of symbiont in host cell
M5E03_RS08575	COG2409	Drug exporters of the RND superfamily
M5E03_RS08580	COG0300	oxidoreductase activity
M5E03_RS08595	COG1426	Protein conserved in bacteria
M5E03_RS08600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5E03_RS08605	COG1058	Belongs to the CinA family
M5E03_RS08605	COG1546	Belongs to the CinA family
M5E03_RS08610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M5E03_RS08615	COG1418	mRNA catabolic process
M5E03_RS08620	COG1692	metallophosphoesterase
M5E03_RS08625	COG2359	stage V sporulation protein S
M5E03_RS08630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E03_RS08635	COG1063	alcohol dehydrogenase
M5E03_RS08640	COG0156	8-amino-7-oxononanoate synthase activity
M5E03_RS08645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E03_RS08650	COG4550	Control of competence regulator ComK, YlbF/YmcA
M5E03_RS08660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M5E03_RS08665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M5E03_RS08680	COG1329	Transcriptional regulator
M5E03_RS08685	COG4195	phage-related replication protein
M5E03_RS08690	COG0457	Tetratricopeptide repeat
M5E03_RS08695	COG1404	Belongs to the peptidase S8 family
M5E03_RS08700	COG4195	phage-related replication protein
M5E03_RS08705	COG1764	response to oxidative stress
M5E03_RS08710	COG2076	Multidrug Resistance protein
M5E03_RS08740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M5E03_RS08745	COG1923	regulation of RNA biosynthetic process
M5E03_RS08760	COG1780	Probably involved in ribonucleotide reductase function
M5E03_RS08765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E03_RS08770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E03_RS08775	COG4112	unkown
M5E03_RS08785	COG0464	growth
M5E03_RS08790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M5E03_RS08795	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M5E03_RS08800	COG0789	Transcriptional regulator
M5E03_RS08805	COG0174	glutamine synthetase
M5E03_RS08830	COG0457	Tetratricopeptide repeat
M5E03_RS08835	COG5444	nuclease activity
M5E03_RS08855	COG5646	InterPro IPR014922
M5E03_RS08860	COG0457	Tetratricopeptide repeat
M5E03_RS08865	COG3619	membrane
M5E03_RS08870	COG1793	dna ligase
M5E03_RS08870	COG3285	dna ligase
M5E03_RS08875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M5E03_RS08880	COG4876	unkown
M5E03_RS08890	COG1959	2 iron, 2 sulfur cluster binding
M5E03_RS08895	COG0702	epimerase
M5E03_RS08900	COG0247	lactate metabolic process
M5E03_RS08905	COG1139	Iron-sulfur cluster binding protein
M5E03_RS08910	COG1556	Lactate utilization protein
M5E03_RS08930	COG2323	membrane
M5E03_RS08935	COG1309	transcriptional regulator
M5E03_RS08940	COG2124	cytochrome p450
M5E03_RS08940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5E03_RS08945	COG3591	Belongs to the peptidase S1B family
M5E03_RS08950	COG3209	COG3209 Rhs family protein
M5E03_RS08955	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_RS08970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M5E03_RS08975	COG1388	LysM domain
M5E03_RS08980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M5E03_RS08985	COG4224	UPF0291 protein
M5E03_RS08990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5E03_RS09000	COG3763	UPF0154 protein
M5E03_RS09010	COG0785	Cytochrome C biogenesis protein
M5E03_RS09015	COG4846	Membrane protein involved in cytochrome C biogenesis
M5E03_RS09025	COG0071	Belongs to the small heat shock protein (HSP20) family
M5E03_RS09040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M5E03_RS09045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_RS09065	COG0824	Thioesterase
M5E03_RS09075	COG4841	protein insertion into membrane
M5E03_RS09080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M5E03_RS09085	COG1832	CoA-binding protein
M5E03_RS09090	COG0187	DNA topoisomerase II activity
M5E03_RS09095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5E03_RS09105	COG0738	Major facilitator superfamily
M5E03_RS09110	COG0110	maltose O-acetyltransferase activity
M5E03_RS09115	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5E03_RS09120	COG1733	regulation of RNA biosynthetic process
M5E03_RS09130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E03_RS09135	COG0251	oxidation-reduction process
M5E03_RS09160	COG0583	DNA-binding transcription factor activity
M5E03_RS09165	COG2851	Citrate transporter
M5E03_RS09170	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E03_RS09175	COG0183	Belongs to the thiolase family
M5E03_RS09180	COG1024	Enoyl-CoA hydratase
M5E03_RS09185	COG1024	Enoyl-CoA hydratase
M5E03_RS09190	COG1024	Enoyl-CoA hydratase
M5E03_RS09195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M5E03_RS09220	COG0657	acetylesterase activity
M5E03_RS09230	COG2723	6-phospho-beta-galactosidase activity
M5E03_RS09235	COG1263	PTS System
M5E03_RS09235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS09235	COG2190	(PTS) system
M5E03_RS09250	COG2205	protein histidine kinase activity
M5E03_RS09255	COG0745	RESPONSE REGULATOR receiver
M5E03_RS09265	COG3507	Belongs to the glycosyl hydrolase 43 family
M5E03_RS09270	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_RS09275	COG1486	melibiose metabolic process
M5E03_RS09280	COG0395	ABC-type sugar transport system, permease component
M5E03_RS09285	COG1175	transmembrane transport
M5E03_RS09290	COG1653	transport
M5E03_RS09295	COG1609	Transcriptional regulator
M5E03_RS09300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E03_RS09315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS09355	COG5444	nuclease activity
M5E03_RS09360	COG1846	Transcriptional regulator
M5E03_RS09365	COG2814	Major facilitator Superfamily
M5E03_RS09375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_RS09375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_RS09375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS09380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_RS09380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_RS09380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS09385	COG1105	Belongs to the carbohydrate kinase PfkB family
M5E03_RS09395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E03_RS09425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5E03_RS09430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E03_RS09435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E03_RS09440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5E03_RS09445	COG1024	Enoyl-CoA hydratase
M5E03_RS09450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E03_RS09455	COG0511	ligase activity, forming carbon-carbon bonds
M5E03_RS09460	COG0439	Biotin carboxylase
M5E03_RS09465	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_RS09470	COG1960	acyl-CoA dehydrogenase activity
M5E03_RS09475	COG1649	PFAM Uncharacterised BCR, COG1649
M5E03_RS09480	COG2365	Tyrosine phosphatase family
M5E03_RS09485	COG1349	DNA-binding transcription factor activity
M5E03_RS09495	COG3835	regulator
M5E03_RS09500	COG0277	FAD linked oxidase domain protein
M5E03_RS09505	COG0247	lactate metabolic process
M5E03_RS09535	COG0166	Belongs to the GPI family
M5E03_RS09540	COG0586	Pfam SNARE associated Golgi protein
M5E03_RS09545	COG1587	Uroporphyrinogen-III synthase
M5E03_RS09555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_RS09570	COG0534	Mate efflux family protein
M5E03_RS09575	COG2027	D-alanyl-D-alanine carboxypeptidase
M5E03_RS09580	COG4677	pectinesterase activity
M5E03_RS09585	COG2323	membrane
M5E03_RS09590	COG2146	nitrite reductase [NAD(P)H] activity
M5E03_RS09595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E03_RS09600	COG0243	molybdopterin cofactor binding
M5E03_RS09605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E03_RS09610	COG2223	nitrite transmembrane transporter activity
M5E03_RS09615	COG0493	'glutamate synthase
M5E03_RS09620	COG0067	glutamate synthase
M5E03_RS09620	COG0069	glutamate synthase activity
M5E03_RS09620	COG0070	glutamate synthase
M5E03_RS09625	COG0583	DNA-binding transcription factor activity
M5E03_RS09640	COG4978	Transcriptional regulator
M5E03_RS09640	COG0789	Transcriptional regulator
M5E03_RS09645	COG0454	-acetyltransferase
M5E03_RS09650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M5E03_RS09655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5E03_RS09670	COG0243	molybdopterin cofactor binding
M5E03_RS09680	COG1070	Carbohydrate kinase
M5E03_RS09685	COG2115	Belongs to the xylose isomerase family
M5E03_RS09700	COG2211	Major facilitator Superfamily
M5E03_RS09705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_RS09710	COG1994	Peptidase M50
M5E03_RS09730	COG1309	transcriptional regulator
M5E03_RS09735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_RS09740	COG3708	Transcriptional regulator
M5E03_RS09745	COG2378	regulation of single-species biofilm formation
M5E03_RS09755	COG0640	Transcriptional regulator
M5E03_RS09760	COG0531	amino acid
M5E03_RS09765	COG0741	lytic transglycosylase activity
M5E03_RS09770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M5E03_RS09775	COG2079	MmgE PrpD family protein
M5E03_RS09780	COG0372	Belongs to the citrate synthase family
M5E03_RS09785	COG2322	membrane
M5E03_RS09795	COG1388	LysM domain
M5E03_RS09795	COG3584	3D domain protein
M5E03_RS09800	COG0514	ATP-dependent DNA helicase (RecQ)
M5E03_RS09810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E03_RS09835	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_RS09840	COG1657	PFAM Prenyltransferase squalene oxidase
M5E03_RS09845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E03_RS09850	COG0385	Bile acid
M5E03_RS09855	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_RS09860	COG0567	Dehydrogenase, E1 component
M5E03_RS09865	COG4548	von Willebrand factor, type A
M5E03_RS09870	COG0714	Associated with various cellular activities
M5E03_RS09875	COG2032	superoxide dismutase activity
M5E03_RS09880	COG1388	LysM domain
M5E03_RS09880	COG0791	NLP P60 protein
M5E03_RS09885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M5E03_RS09890	COG0534	Mate efflux family protein
M5E03_RS09895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5E03_RS09900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5E03_RS09910	COG2962	Rard protein
M5E03_RS09925	COG1733	regulation of RNA biosynthetic process
M5E03_RS09930	COG0778	Nitroreductase
M5E03_RS09940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E03_RS09945	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_RS09945	COG0793	Belongs to the peptidase S41A family
M5E03_RS09950	COG2226	methyltransferase
M5E03_RS09960	COG1876	peptidase activity
M5E03_RS09965	COG0813	purine-nucleoside phosphorylase activity
M5E03_RS09975	COG0671	phosphoesterase, PA-phosphatase related
M5E03_RS09990	COG4479	Belongs to the UPF0346 family
M5E03_RS10000	COG1509	lysine 2,3-aminomutase activity
M5E03_RS10005	COG3829	transcription factor binding
M5E03_RS10010	COG0463	Glycosyl transferase, family 2
M5E03_RS10025	COG4641	Protein conserved in bacteria
M5E03_RS10035	COG1086	Polysaccharide biosynthesis protein
M5E03_RS10040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5E03_RS10045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5E03_RS10050	COG1846	Transcriptional regulator
M5E03_RS10070	COG4698	Protein conserved in bacteria
M5E03_RS10075	COG2755	lipolytic protein G-D-S-L family
M5E03_RS10080	COG1999	signal sequence binding
M5E03_RS10095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M5E03_RS10100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M5E03_RS10105	COG1272	protein, Hemolysin III
M5E03_RS10110	COG0204	Acyl-transferase
M5E03_RS10115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5E03_RS10120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M5E03_RS10125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5E03_RS10135	COG2521	methyltransferase
M5E03_RS10135	COG2136	Putative SAM-dependent methyltransferase
M5E03_RS10145	COG0129	dihydroxy-acid dehydratase activity
M5E03_RS10150	COG1413	lyase activity
M5E03_RS10155	COG1418	mRNA catabolic process
M5E03_RS10160	COG0386	Belongs to the glutathione peroxidase family
M5E03_RS10165	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M5E03_RS10170	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M5E03_RS10175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5E03_RS10185	COG1278	Cold shock
M5E03_RS10200	COG0328	RNA-DNA hybrid ribonuclease activity
M5E03_RS10205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M5E03_RS10210	COG0328	RNA-DNA hybrid ribonuclease activity
M5E03_RS10220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5E03_RS10230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M5E03_RS10235	COG1755	Isoprenylcysteine carboxyl methyltransferase
M5E03_RS10240	COG3424	synthase
M5E03_RS10245	COG0726	polysaccharide deacetylase
M5E03_RS10250	COG2233	PERMEase
M5E03_RS10255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E03_RS10260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M5E03_RS10265	COG1199	ATP-dependent helicase activity
M5E03_RS10275	COG0116	Belongs to the methyltransferase superfamily
M5E03_RS10285	COG3599	regulation of cell shape
M5E03_RS10290	COG4474	Belongs to the UPF0398 family
M5E03_RS10300	COG3359	exonuclease
M5E03_RS10305	COG1111	helicase
M5E03_RS10305	COG1205	dead DEAH box helicase
M5E03_RS10310	COG1902	pentaerythritol trinitrate reductase activity
M5E03_RS10315	COG2190	(PTS) system
M5E03_RS10320	COG0071	Belongs to the small heat shock protein (HSP20) family
M5E03_RS10350	COG3331	DNA recombination
M5E03_RS10355	COG4499	WXG100 protein secretion system (Wss), protein YukC
M5E03_RS10355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E03_RS10365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M5E03_RS10370	COG3935	DnaD domain protein
M5E03_RS10375	COG0017	Asparaginyl-tRNA synthetase
M5E03_RS10380	COG5353	protein conserved in bacteria
M5E03_RS10390	COG1199	ATP-dependent helicase activity
M5E03_RS10390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5E03_RS10395	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M5E03_RS10400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M5E03_RS10405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M5E03_RS10415	COG0617	tRNA 3'-terminal CCA addition
M5E03_RS10420	COG0438	transferase activity, transferring glycosyl groups
M5E03_RS10425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5E03_RS10430	COG1803	Methylglyoxal synthase
M5E03_RS10435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M5E03_RS10440	COG1694	Mazg nucleotide pyrophosphohydrolase
M5E03_RS10445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_RS10455	COG4347	Protein of unknown function (DUF1405)
M5E03_RS10460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5E03_RS10460	COG2010	Cytochrome c
M5E03_RS10465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5E03_RS10470	COG0723	plastoquinol--plastocyanin reductase activity
M5E03_RS10480	COG5582	Belongs to the UPF0302 family
M5E03_RS10485	COG0457	Tetratricopeptide repeat
M5E03_RS10490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M5E03_RS10495	COG0287	Prephenate dehydrogenase
M5E03_RS10500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M5E03_RS10505	COG0159	tryptophan synthase activity
M5E03_RS10510	COG0133	tryptophan synthase activity
M5E03_RS10515	COG0135	phosphoribosylanthranilate isomerase activity
M5E03_RS10520	COG0134	indole-3-glycerol-phosphate synthase activity
M5E03_RS10535	COG4401	Chorismate mutase type I
M5E03_RS10540	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M5E03_RS10545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M5E03_RS10550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M5E03_RS10555	COG0105	UTP biosynthetic process
M5E03_RS10560	COG0142	geranyltranstransferase activity
M5E03_RS10565	COG2226	methyltransferase
M5E03_RS10570	COG0142	geranyltranstransferase activity
M5E03_RS10580	COG0302	gtp cyclohydrolase
M5E03_RS10585	COG0776	regulation of translation
M5E03_RS10590	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M5E03_RS10605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M5E03_RS10610	COG1160	GTP binding
M5E03_RS10635	COG1304	FMN binding
M5E03_RS10640	COG0539	negative regulation of cytoplasmic translation
M5E03_RS10645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M5E03_RS10655	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M5E03_RS10660	COG2959	enzyme of heme biosynthesis
M5E03_RS10665	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_RS10665	COG3773	Cell wall hydrolase
M5E03_RS10670	COG2339	peptidase activity
M5E03_RS10675	COG0492	ferredoxin-NADP+ reductase activity
M5E03_RS10680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E03_RS10685	COG4862	establishment of competence for transformation
M5E03_RS10690	COG1408	metallophosphoesterase
M5E03_RS10700	COG1388	LysM domain
M5E03_RS10705	COG1266	CAAX protease self-immunity
M5E03_RS10710	COG0514	ATP-dependent DNA helicase (RecQ)
M5E03_RS10715	COG4955	Helix-turn-helix domain
M5E03_RS10720	COG1141	Ferredoxin
M5E03_RS10725	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M5E03_RS10730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5E03_RS10735	COG1388	LysM domain
M5E03_RS10735	COG0791	NLP P60 protein
M5E03_RS10745	COG1595	DNA-templated transcription, initiation
M5E03_RS10750	COG5002	protein histidine kinase activity
M5E03_RS10755	COG0745	RESPONSE REGULATOR receiver
M5E03_RS10760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5E03_RS10765	COG1333	cytochrome c biogenesis protein
M5E03_RS10770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_RS10775	COG1187	pseudouridine synthase activity
M5E03_RS10780	COG0700	Nucleoside recognition
M5E03_RS10785	COG2715	membrane protein required for spore maturation
M5E03_RS10790	COG1686	Belongs to the peptidase S11 family
M5E03_RS10800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M5E03_RS10805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M5E03_RS10815	COG1547	Domain of unknown function (DUF309)
M5E03_RS10820	COG0456	acetyltransferase
M5E03_RS10825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M5E03_RS10835	COG0307	riboflavin synthase, alpha
M5E03_RS10855	COG2814	Major facilitator Superfamily
M5E03_RS10860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5E03_RS10865	COG4086	secreted protein
M5E03_RS10870	COG0019	diaminopimelate decarboxylase activity
M5E03_RS10875	COG0697	spore germination
M5E03_RS10890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5E03_RS10910	COG1191	sigma factor activity
M5E03_RS10915	COG2172	sigma factor antagonist activity
M5E03_RS10925	COG1686	Belongs to the peptidase S11 family
M5E03_RS10930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M5E03_RS10935	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M5E03_RS10940	COG4974	Belongs to the 'phage' integrase family
M5E03_RS10950	COG0735	belongs to the Fur family
M5E03_RS10955	COG1300	Membrane
M5E03_RS10960	COG1404	Belongs to the peptidase S8 family
M5E03_RS10970	COG2153	protein acetylation
M5E03_RS10975	COG1379	DNA repair
M5E03_RS10980	COG0494	nUDIX hydrolase
M5E03_RS10985	COG0667	Aldo Keto reductase
M5E03_RS11000	COG1073	alpha beta
M5E03_RS11005	COG0457	Tetratricopeptide repeat
M5E03_RS11015	COG4918	Iron-sulphur cluster biosynthesis
M5E03_RS11020	COG0456	acetyltransferase
M5E03_RS11020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M5E03_RS11025	COG0456	acetyltransferase
M5E03_RS11035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5E03_RS11045	COG2211	Major facilitator Superfamily
M5E03_RS11050	COG1072	(Pantothenic acid kinase))
M5E03_RS11055	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5E03_RS11060	COG0300	oxidoreductase activity
M5E03_RS11065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_RS11070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5E03_RS11080	COG4187	Peptidase family M20/M25/M40
M5E03_RS11085	COG1902	pentaerythritol trinitrate reductase activity
M5E03_RS11090	COG0596	Alpha beta hydrolase
M5E03_RS11095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_RS11105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M5E03_RS11110	COG2188	Transcriptional regulator
M5E03_RS11115	COG2723	6-phospho-beta-galactosidase activity
M5E03_RS11120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_RS11125	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5E03_RS11130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS11145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M5E03_RS11150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5E03_RS11165	COG0706	membrane insertase activity
M5E03_RS11175	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5E03_RS11180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5E03_RS11185	COG0346	lactoylglutathione lyase activity
M5E03_RS11195	COG1376	ErfK ybiS ycfS ynhG family protein
M5E03_RS11200	COG4129	membrane
M5E03_RS11205	COG1126	abc transporter atp-binding protein
M5E03_RS11210	COG0765	amino acid transport
M5E03_RS11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_RS11225	COG1597	lipid kinase activity
M5E03_RS11235	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_RS11240	COG0022	dehydrogenase e1 component
M5E03_RS11245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E03_RS11250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E03_RS11255	COG3426	butyrate kinase activity
M5E03_RS11260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E03_RS11265	COG0280	phosphate acetyltransferase
M5E03_RS11270	COG3290	protein histidine kinase activity
M5E03_RS11270	COG3829	transcription factor binding
M5E03_RS11280	COG0584	glycerophosphoryl diester phosphodiesterase
M5E03_RS11285	COG0457	Tetratricopeptide repeat
M5E03_RS11295	COG0745	RESPONSE REGULATOR receiver
M5E03_RS11300	COG0750	zinc metalloprotease
M5E03_RS11305	COG0497	DNA recombination
M5E03_RS11310	COG1438	arginine binding
M5E03_RS11315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M5E03_RS11320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M5E03_RS11325	COG0142	geranyltranstransferase activity
M5E03_RS11330	COG1722	exodeoxyribonuclease VII activity
M5E03_RS11335	COG1570	exodeoxyribonuclease VII activity
M5E03_RS11340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M5E03_RS11345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5E03_RS11350	COG1302	Protein conserved in bacteria
M5E03_RS11355	COG0439	Biotin carboxylase
M5E03_RS11360	COG0511	ligase activity, forming carbon-carbon bonds
M5E03_RS11400	COG3854	ATPases associated with a variety of cellular activities
M5E03_RS11410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5E03_RS11415	COG0006	proline dipeptidase activity
M5E03_RS11420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M5E03_RS11430	COG3872	metal-dependent enzyme
M5E03_RS11440	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E03_RS11445	COG1321	iron dependent repressor
M5E03_RS11450	COG0095	Lipoate-protein ligase
M5E03_RS11455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E03_RS11460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5E03_RS11465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5E03_RS11470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M5E03_RS11475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5E03_RS11500	COG0681	Belongs to the peptidase S26 family
M5E03_RS11530	COG4970	Tfp pilus assembly protein FimT
M5E03_RS11535	COG4537	Required for transformation and DNA binding
M5E03_RS11540	COG1459	type II secretion system
M5E03_RS11545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5E03_RS11550	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_RS11560	COG1393	Belongs to the ArsC family
M5E03_RS11570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_RS11580	COG0011	TIGRFAM Protein of
M5E03_RS11585	COG2814	Major facilitator Superfamily
M5E03_RS11590	COG2866	Carboxypeptidase
M5E03_RS11595	COG1368	sulfuric ester hydrolase activity
M5E03_RS11600	COG1940	carbohydrate kinase activity
M5E03_RS11605	COG4483	Protein conserved in bacteria
M5E03_RS11610	COG0457	Tetratricopeptide repeat
M5E03_RS11610	COG0705	Rhomboid family
M5E03_RS11625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M5E03_RS11630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M5E03_RS11640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5E03_RS11645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E03_RS11650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E03_RS11655	COG0581	inorganic phosphate transmembrane transporter activity
M5E03_RS11660	COG0573	inorganic phosphate transmembrane transporter activity
M5E03_RS11665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M5E03_RS11670	COG0768	penicillin binding
M5E03_RS11675	COG0477	Major facilitator Superfamily
M5E03_RS11680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E03_RS11685	COG2839	Protein conserved in bacteria
M5E03_RS11690	COG5521	maltodextrose utilization protein MalA
M5E03_RS11695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_RS11700	COG1388	LysM domain
M5E03_RS11705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M5E03_RS11710	COG4709	membrane
M5E03_RS11715	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M5E03_RS11720	COG1940	carbohydrate kinase activity
M5E03_RS11725	COG0735	belongs to the Fur family
M5E03_RS11730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5E03_RS11735	COG1121	(ABC) transporter
M5E03_RS11740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_RS11755	COG0513	Belongs to the DEAD box helicase family
M5E03_RS11765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M5E03_RS11770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5E03_RS11775	COG2384	SAM-dependent methyltransferase
M5E03_RS11780	COG2010	Cytochrome c
M5E03_RS11785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M5E03_RS11790	COG0358	DNA primase activity
M5E03_RS11795	COG1671	Belongs to the UPF0178 family
M5E03_RS11800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M5E03_RS11805	COG0517	IMP dehydrogenase activity
M5E03_RS11810	COG0751	glycine-tRNA ligase activity
M5E03_RS11815	COG0752	glycyl-tRNA synthetase alpha subunit
M5E03_RS11820	COG1381	Involved in DNA repair and RecF pathway recombination
M5E03_RS11830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5E03_RS11835	COG0295	cytidine deaminase activity
M5E03_RS11840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5E03_RS11845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M5E03_RS11850	COG1480	7TM receptor with intracellular HD hydrolase
M5E03_RS11855	COG1702	phosphate starvation-inducible protein PhoH
M5E03_RS11860	COG0561	phosphatase activity
M5E03_RS11875	COG4864	UPF0365 protein
M5E03_RS11880	COG1030	water channel activity
M5E03_RS11885	COG1610	YqeY-like protein
M5E03_RS11895	COG1283	sodium-dependent phosphate transmembrane transporter activity
M5E03_RS11900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E03_RS11905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5E03_RS11910	COG2264	protein methyltransferase activity
M5E03_RS11915	COG0484	heat shock protein binding
M5E03_RS11920	COG0443	Heat shock 70 kDa protein
M5E03_RS11925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M5E03_RS11930	COG1420	regulation of RNA biosynthetic process
M5E03_RS11935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E03_RS11940	COG0481	GTPase activity
M5E03_RS11950	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_RS11955	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M5E03_RS11960	COG0268	Binds directly to 16S ribosomal RNA
M5E03_RS11965	COG1466	dna polymerase III delta subunit
M5E03_RS11975	COG0658	competence protein
M5E03_RS11975	COG2333	competence protein COMEC
M5E03_RS11980	COG2131	deaminase
M5E03_RS11985	COG1555	photosystem II stabilization
M5E03_RS11990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5E03_RS11995	COG2226	methyltransferase
M5E03_RS12000	COG0799	negative regulation of ribosome biogenesis
M5E03_RS12005	COG1713	HD superfamily hydrolase involved in NAD metabolism
M5E03_RS12010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M5E03_RS12015	COG1534	Rna-binding protein
M5E03_RS12020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M5E03_RS12025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5E03_RS12030	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M5E03_RS12045	COG2755	lipolytic protein G-D-S-L family
M5E03_RS12055	COG0457	Tetratricopeptide repeat
M5E03_RS12065	COG2318	DinB family
M5E03_RS12090	COG0726	polysaccharide deacetylase
M5E03_RS12125	COG1131	(ABC) transporter
M5E03_RS12145	COG2160	L-arabinose isomerase activity
M5E03_RS12160	COG1609	Transcriptional regulator
M5E03_RS12170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M5E03_RS12175	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M5E03_RS12180	COG1733	regulation of RNA biosynthetic process
M5E03_RS12185	COG0657	acetylesterase activity
M5E03_RS12230	COG1309	transcriptional regulator
M5E03_RS12235	COG0109	protoheme IX farnesyltransferase activity
M5E03_RS12240	COG2602	Beta-lactamase
M5E03_RS12245	COG1960	acyl-CoA dehydrogenase activity
M5E03_RS12250	COG1126	abc transporter atp-binding protein
M5E03_RS12255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_RS12260	COG0765	amino acid transport
M5E03_RS12270	COG3546	catalase activity
M5E03_RS12275	COG1063	alcohol dehydrogenase
M5E03_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS12290	COG1132	(ABC) transporter
M5E03_RS12295	COG0454	-acetyltransferase
M5E03_RS12300	COG2226	methyltransferase
M5E03_RS12305	COG1063	alcohol dehydrogenase
M5E03_RS12310	COG2226	methyltransferase
M5E03_RS12335	COG0626	cystathionine gamma-synthase activity
M5E03_RS12340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E03_RS12345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5E03_RS12350	COG2226	methyltransferase
M5E03_RS12365	COG0768	penicillin binding
M5E03_RS12370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5E03_RS12380	COG0572	uridine kinase
M5E03_RS12385	COG0826	peptidase U32
M5E03_RS12390	COG0826	peptidase U32
M5E03_RS12395	COG4122	O-methyltransferase activity
M5E03_RS12400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5E03_RS12405	COG0183	Belongs to the thiolase family
M5E03_RS12410	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_RS12415	COG1268	BioY protein
M5E03_RS12420	COG3906	Belongs to the UPF0473 family
M5E03_RS12425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M5E03_RS12430	COG4472	Bacterial protein of unknown function (DUF965)
M5E03_RS12435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M5E03_RS12440	COG0628	permease
M5E03_RS12445	COG1126	abc transporter atp-binding protein
M5E03_RS12450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_RS12455	COG0765	amino acid transport
M5E03_RS12460	COG0765	amino acid transport
M5E03_RS12475	COG3881	PFAM PRC-barrel domain
M5E03_RS12480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5E03_RS12485	COG0457	Tetratricopeptide repeat
M5E03_RS12490	COG0482	sulfurtransferase activity
M5E03_RS12495	COG1104	cysteine desulfurase activity
M5E03_RS12500	COG1959	2 iron, 2 sulfur cluster binding
M5E03_RS12505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M5E03_RS12510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M5E03_RS12525	COG0124	histidyl-tRNA synthetase
M5E03_RS12535	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_RS12535	COG3103	Sh3 type 3 domain protein
M5E03_RS12535	COG4991	sh3 domain protein
M5E03_RS12540	COG1490	D-aminoacyl-tRNA deacylase activity
M5E03_RS12545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5E03_RS12550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E03_RS12555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5E03_RS12555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M5E03_RS12560	COG5416	Lipopolysaccharide assembly protein A domain
M5E03_RS12565	COG0490	domain, Protein
M5E03_RS12570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5E03_RS12570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5E03_RS12580	COG2244	polysaccharide biosynthetic process
M5E03_RS12585	COG2323	membrane
M5E03_RS12595	COG1862	Preprotein translocase
M5E03_RS12600	COG0343	queuine tRNA-ribosyltransferase activity
M5E03_RS12605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M5E03_RS12615	COG2255	four-way junction helicase activity
M5E03_RS12620	COG0632	four-way junction helicase activity
M5E03_RS12630	COG2112	serine threonine protein kinase
M5E03_RS12645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M5E03_RS12660	COG1388	LysM domain
M5E03_RS12660	COG1388	LysM domain
M5E03_RS12665	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M5E03_RS12670	COG0157	Belongs to the NadC ModD family
M5E03_RS12675	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M5E03_RS12680	COG1104	cysteine desulfurase activity
M5E03_RS12685	COG1827	regulation of RNA biosynthetic process
M5E03_RS12690	COG0077	Prephenate dehydratase
M5E03_RS12695	COG4492	Belongs to the UPF0735 family
M5E03_RS12700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M5E03_RS12705	COG3290	protein histidine kinase activity
M5E03_RS12710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M5E03_RS12715	COG2868	ribosomal protein
M5E03_RS12720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M5E03_RS12725	COG1994	Peptidase M50
M5E03_RS12730	COG0739	heme binding
M5E03_RS12735	COG2894	cell division
M5E03_RS12740	COG0850	regulation of cytokinetic process
M5E03_RS12745	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M5E03_RS12755	COG1077	Cell shape determining protein MreB Mrl
M5E03_RS12760	COG2003	Belongs to the UPF0758 family
M5E03_RS12765	COG0424	maF-like protein
M5E03_RS12775	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M5E03_RS12785	COG0285	dihydrofolate synthase activity
M5E03_RS12790	COG0525	valine-tRNA ligase activity
M5E03_RS12800	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E03_RS12805	COG1388	LysM domain
M5E03_RS12810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M5E03_RS12815	COG0113	porphobilinogen synthase activity
M5E03_RS12820	COG1587	Uroporphyrinogen-III synthase
M5E03_RS12825	COG0181	hydroxymethylbilane synthase activity
M5E03_RS12830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5E03_RS12835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M5E03_RS12845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M5E03_RS12850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M5E03_RS12855	COG0470	DNA polymerase III
M5E03_RS12855	COG1067	ATP-dependent peptidase activity
M5E03_RS12860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M5E03_RS12865	COG0544	peptidyl-prolyl cis-trans isomerase activity
M5E03_RS12870	COG0457	Tetratricopeptide repeat
M5E03_RS12870	COG1477	protein flavinylation
M5E03_RS12875	COG0066	3-isopropylmalate dehydratase activity
M5E03_RS12880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M5E03_RS12885	COG0473	3-isopropylmalate dehydrogenase activity
M5E03_RS12890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E03_RS12895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M5E03_RS12900	COG0440	acetolactate synthase activity
M5E03_RS12905	COG0028	Belongs to the TPP enzyme family
M5E03_RS12910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E03_RS12915	COG2706	6-phosphogluconolactonase activity
M5E03_RS12920	COG3339	Conserved Protein
M5E03_RS12925	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M5E03_RS12930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E03_RS12935	COG1696	Membrane protein involved in D-alanine export
M5E03_RS12975	COG0622	Phosphoesterase
M5E03_RS12980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M5E03_RS12985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M5E03_RS12990	COG5401	PFAM Sporulation and spore germination
M5E03_RS12995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5E03_RS13000	COG1846	Transcriptional regulator
M5E03_RS13005	COG2197	response regulator
M5E03_RS13010	COG2851	Citrate transporter
M5E03_RS13015	COG0583	DNA-binding transcription factor activity
M5E03_RS13020	COG2828	Protein conserved in bacteria
M5E03_RS13030	COG0824	Thioesterase
M5E03_RS13035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5E03_RS13040	COG1053	succinate dehydrogenase
M5E03_RS13045	COG2009	succinate dehydrogenase
M5E03_RS13050	COG1719	4-vinyl reductase, 4VR
M5E03_RS13055	COG0527	aspartate kinase activity
M5E03_RS13060	COG0322	excinuclease ABC activity
M5E03_RS13065	COG3118	belongs to the thioredoxin family
M5E03_RS13070	COG3534	alpha-L-arabinofuranosidase
M5E03_RS13075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M5E03_RS13080	COG2086	electron transfer activity
M5E03_RS13085	COG1024	Enoyl-CoA hydratase
M5E03_RS13090	COG1309	transcriptional regulator
M5E03_RS13095	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_RS13105	COG3766	membrane
M5E03_RS13110	COG1193	negative regulation of DNA recombination
M5E03_RS13115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5E03_RS13115	COG1796	DNA polymerase
M5E03_RS13120	COG1286	toxin biosynthetic process
M5E03_RS13125	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M5E03_RS13130	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5E03_RS13135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_RS13135	COG0072	phenylalanine-tRNA ligase activity
M5E03_RS13140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M5E03_RS13145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E03_RS13155	COG1966	Carbon starvation protein
M5E03_RS13160	COG1363	Peptidase, m42
M5E03_RS13170	COG3326	Membrane
M5E03_RS13175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M5E03_RS13180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M5E03_RS13185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M5E03_RS13190	COG1346	cytolysis
M5E03_RS13200	COG3279	Response regulator of the LytR AlgR family
M5E03_RS13205	COG3275	phosphorelay sensor kinase activity
M5E03_RS13210	COG1011	Hydrolase
M5E03_RS13220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5E03_RS13230	COG0398	Pfam SNARE associated Golgi protein
M5E03_RS13235	COG1484	DNA-dependent DNA replication
M5E03_RS13240	COG3611	Membrane attachment protein
M5E03_RS13245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M5E03_RS13255	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M5E03_RS13260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5E03_RS13265	COG0237	dephospho-CoA kinase activity
M5E03_RS13270	COG1971	Probably functions as a manganese efflux pump
M5E03_RS13275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M5E03_RS13280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5E03_RS13280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5E03_RS13285	COG5002	protein histidine kinase activity
M5E03_RS13290	COG0745	RESPONSE REGULATOR receiver
M5E03_RS13295	COG0039	L-malate dehydrogenase activity
M5E03_RS13300	COG0538	isocitrate dehydrogenase activity
M5E03_RS13305	COG0372	Belongs to the citrate synthase family
M5E03_RS13310	COG2707	UPF0756 membrane protein
M5E03_RS13315	COG0628	permease
M5E03_RS13320	COG3030	protein affecting phage T7 exclusion by the F plasmid
M5E03_RS13330	COG0205	6-phosphofructokinase activity
M5E03_RS13335	COG0825	malonyl-CoA metabolic process
M5E03_RS13340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M5E03_RS13345	COG0281	malic enzyme
M5E03_RS13350	COG0587	DNA-directed DNA polymerase activity
M5E03_RS13370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M5E03_RS13380	COG4109	DRTGG domain
M5E03_RS13385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5E03_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS13400	COG0165	Argininosuccinate lyase
M5E03_RS13405	COG0137	argininosuccinate synthase activity
M5E03_RS13410	COG0521	Mo-molybdopterin cofactor biosynthetic process
M5E03_RS13415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5E03_RS13420	COG0827	DNA restriction-modification system
M5E03_RS13425	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M5E03_RS13430	COG3874	Sporulation protein YtfJ
M5E03_RS13440	COG1714	RDD family
M5E03_RS13445	COG0616	signal peptide processing
M5E03_RS13450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5E03_RS13460	COG3239	Fatty acid desaturase
M5E03_RS13465	COG4585	Histidine kinase
M5E03_RS13470	COG2197	response regulator
M5E03_RS13475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_RS13480	COG0745	RESPONSE REGULATOR receiver
M5E03_RS13485	COG0642	Histidine kinase
M5E03_RS13490	COG0772	Belongs to the SEDS family
M5E03_RS13495	COG1695	Transcriptional regulator
M5E03_RS13500	COG1136	(ABC) transporter
M5E03_RS13505	COG0577	efflux transmembrane transporter activity
M5E03_RS13510	COG0402	S-adenosylhomocysteine deaminase activity
M5E03_RS13515	COG1279	arginine transmembrane transporter activity
M5E03_RS13520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E03_RS13530	COG0301	tRNA thio-modification
M5E03_RS13535	COG1104	cysteine desulfurase activity
M5E03_RS13540	COG1114	Component of the transport system for branched-chain amino acids
M5E03_RS13545	COG1114	Component of the transport system for branched-chain amino acids
M5E03_RS13550	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M5E03_RS13555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5E03_RS13560	COG1309	transcriptional regulator
M5E03_RS13565	COG1956	GAF domain-containing protein
M5E03_RS13570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M5E03_RS13580	COG1335	isochorismatase
M5E03_RS13585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5E03_RS13590	COG2329	Antibiotic biosynthesis monooxygenase
M5E03_RS13595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5E03_RS13600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E03_RS13605	COG0454	-acetyltransferase
M5E03_RS13610	COG0517	IMP dehydrogenase activity
M5E03_RS13615	COG0123	including yeast histone deacetylase and acetoin utilization protein
M5E03_RS13620	COG1609	Transcriptional regulator
M5E03_RS13625	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M5E03_RS13625	COG1605	Chorismate mutase
M5E03_RS13630	COG3118	belongs to the thioredoxin family
M5E03_RS13635	COG4980	gas vesicle protein
M5E03_RS13640	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M5E03_RS13645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5E03_RS13650	COG1674	ftsk spoiiie
M5E03_RS13655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_RS13660	COG4848	Belongs to the UPF0354 family
M5E03_RS13665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_RS13680	COG1363	Peptidase, m42
M5E03_RS13685	COG5584	Small secreted protein
M5E03_RS13690	COG0281	malic enzyme
M5E03_RS13695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_RS13700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M5E03_RS13710	COG0510	thiamine kinase activity
M5E03_RS13715	COG1597	lipid kinase activity
M5E03_RS13725	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M5E03_RS13730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E03_RS13735	COG3340	Belongs to the peptidase S51 family
M5E03_RS13740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5E03_RS13745	COG2252	PERMEase
M5E03_RS13750	COG1349	DNA-binding transcription factor activity
M5E03_RS13755	COG1187	pseudouridine synthase activity
M5E03_RS13760	COG2244	polysaccharide biosynthetic process
M5E03_RS13765	COG2081	HI0933 family
M5E03_RS13775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5E03_RS13790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E03_RS13795	COG5578	integral membrane protein
M5E03_RS13800	COG0673	inositol 2-dehydrogenase activity
M5E03_RS13805	COG1653	transport
M5E03_RS13810	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M5E03_RS13815	COG4209	transmembrane transport
M5E03_RS13820	COG2207	Transcriptional regulator
M5E03_RS13825	COG1733	regulation of RNA biosynthetic process
M5E03_RS13830	COG2814	Major facilitator Superfamily
M5E03_RS13835	COG0656	L-ascorbic acid biosynthetic process
M5E03_RS13840	COG1653	transport
M5E03_RS13845	COG0395	ABC-type sugar transport system, permease component
M5E03_RS13850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E03_RS13855	COG1073	alpha beta
M5E03_RS13860	COG0495	leucyl-tRNA aminoacylation
M5E03_RS13870	COG2202	Pas domain
M5E03_RS13870	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_RS13875	COG2433	Pfam Transposase IS66
M5E03_RS13880	COG0577	efflux transmembrane transporter activity
M5E03_RS13885	COG1136	(ABC) transporter
M5E03_RS13895	COG1131	(ABC) transporter
M5E03_RS13900	COG1725	Transcriptional regulator
M5E03_RS13915	COG1242	4 iron, 4 sulfur cluster binding
M5E03_RS13920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M5E03_RS13930	COG2267	carboxylic ester hydrolase activity
M5E03_RS13935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M5E03_RS13940	COG0367	asparagine synthase
M5E03_RS13945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M5E03_RS13950	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M5E03_RS13960	COG1506	peptidase
M5E03_RS13965	COG1233	COG1233 Phytoene dehydrogenase and related
M5E03_RS13985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E03_RS13990	COG1116	anion transmembrane transporter activity
M5E03_RS13995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5E03_RS14000	COG0494	nUDIX hydrolase
M5E03_RS14005	COG2310	stress, protein
M5E03_RS14020	COG4824	toxin secretion phage lysis holin
M5E03_RS14030	COG0783	Belongs to the Dps family
M5E03_RS14045	COG1854	S-ribosylhomocysteine lyase activity
M5E03_RS14050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M5E03_RS14055	COG0288	reversible hydration of carbon dioxide
M5E03_RS14060	COG3443	Belongs to the bacterial solute-binding protein 9 family
M5E03_RS14060	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5E03_RS14065	COG0254	rRNA binding
M5E03_RS14070	COG1271	oxidase subunit
M5E03_RS14075	COG1294	oxidase, subunit
M5E03_RS14090	COG4948	Mandelate Racemase Muconate Lactonizing
M5E03_RS14095	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_RS14100	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M5E03_RS14105	COG0596	Alpha beta hydrolase
M5E03_RS14110	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M5E03_RS14115	COG1169	isochorismate synthase
M5E03_RS14120	COG1575	Belongs to the MenA family. Type 1 subfamily
M5E03_RS14125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E03_RS14255	COG3859	Proton-coupled thiamine transporter YuaJ
M5E03_RS14265	COG1247	-acetyltransferase
M5E03_RS14270	COG2268	Band 7 protein
M5E03_RS14275	COG1585	Membrane protein implicated in regulation of membrane protease activity
M5E03_RS14280	COG2318	DinB family
M5E03_RS14285	COG1454	alcohol dehydrogenase
M5E03_RS14290	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_RS14295	COG1510	regulation of RNA biosynthetic process
M5E03_RS14310	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_RS14310	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5E03_RS14355	COG3778	Protein conserved in bacteria
M5E03_RS14360	COG3299	homolog of phage Mu protein gp47
M5E03_RS14365	COG3628	GPW Gp25 family protein
M5E03_RS14375	COG4193	domain, Protein
M5E03_RS14380	COG1652	LysM domain
M5E03_RS14385	COG3953	SLT domain
M5E03_RS14385	COG5280	Phage tail tape measure protein TP901
M5E03_RS14435	COG4653	Phage capsid family
M5E03_RS14440	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M5E03_RS14445	COG5518	Phage portal protein
M5E03_RS14450	COG1783	phage Terminase large subunit
M5E03_RS14455	COG5484	DNA packaging
M5E03_RS14460	COG1595	DNA-templated transcription, initiation
M5E03_RS14490	COG1396	sequence-specific DNA binding
M5E03_RS14500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M5E03_RS14510	COG1968	undecaprenyl-diphosphatase activity
M5E03_RS14515	COG0628	permease
M5E03_RS14525	COG0673	inositol 2-dehydrogenase activity
M5E03_RS14530	COG0693	protein deglycase activity
M5E03_RS14535	COG0840	transmembrane signaling receptor activity
M5E03_RS14540	COG0840	transmembrane signaling receptor activity
M5E03_RS14545	COG0840	transmembrane signaling receptor activity
M5E03_RS14550	COG0840	transmembrane signaling receptor activity
M5E03_RS14565	COG2070	2-Nitropropane dioxygenase
M5E03_RS14570	COG0432	Pfam Uncharacterised protein family UPF0047
M5E03_RS14575	COG1253	flavin adenine dinucleotide binding
M5E03_RS14580	COG2738	Putative neutral zinc metallopeptidase
M5E03_RS14590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5E03_RS14605	COG0166	Belongs to the GPI family
M5E03_RS14610	COG1979	alcohol dehydrogenase
M5E03_RS14615	COG1979	alcohol dehydrogenase
M5E03_RS14620	COG2155	Conserved Protein
M5E03_RS14625	COG1098	S1 RNA binding domain
M5E03_RS14630	COG0436	Aminotransferase
M5E03_RS14635	COG1522	sequence-specific DNA binding
M5E03_RS14640	COG2267	carboxylic ester hydrolase activity
M5E03_RS14650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M5E03_RS14655	COG2205	protein histidine kinase activity
M5E03_RS14670	COG5018	Exonuclease
M5E03_RS14675	COG2814	Major facilitator Superfamily
M5E03_RS14680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E03_RS14685	COG3011	Protein conserved in bacteria
M5E03_RS14695	COG3290	protein histidine kinase activity
M5E03_RS14700	COG4565	transcriptional regulatory protein
M5E03_RS14705	COG1744	ABC transporter substrate-binding protein PnrA-like
M5E03_RS14710	COG3845	ABC transporter
M5E03_RS14715	COG4603	Belongs to the binding-protein-dependent transport system permease family
M5E03_RS14720	COG1079	Belongs to the binding-protein-dependent transport system permease family
M5E03_RS14725	COG3493	citrate carrier protein
M5E03_RS14735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M5E03_RS14735	COG2111	Na H antiporter
M5E03_RS14740	COG2111	Na H antiporter
M5E03_RS14745	COG1006	Multisubunit Na H antiporter MnhC subunit
M5E03_RS14750	COG0651	ATP synthesis coupled electron transport
M5E03_RS14755	COG1863	multisubunit Na H antiporter MnhE subunit
M5E03_RS14760	COG2212	antiporter activity
M5E03_RS14765	COG1320	monovalent cation:proton antiporter activity
M5E03_RS14770	COG2050	protein possibly involved in aromatic compounds catabolism
M5E03_RS14775	COG2197	response regulator
M5E03_RS14780	COG4585	Histidine kinase
M5E03_RS14790	COG0142	geranyltranstransferase activity
M5E03_RS14805	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5E03_RS14810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M5E03_RS14815	COG1335	isochorismatase
M5E03_RS14820	COG5506	Protein of unknown function (DUF1694)
M5E03_RS14840	COG0628	permease
M5E03_RS14855	COG1418	mRNA catabolic process
M5E03_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS14870	COG1511	domain protein
M5E03_RS14875	COG0433	COG0433 Predicted ATPase
M5E03_RS14875	COG1674	ftsk spoiiie
M5E03_RS14880	COG4499	WXG100 protein secretion system (Wss), protein YukC
M5E03_RS14885	COG5417	Belongs to the EsaB family
M5E03_RS14890	COG4842	Belongs to the WXG100 family
M5E03_RS14895	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M5E03_RS14895	COG2508	Transcriptional regulator
M5E03_RS14900	COG0686	Belongs to the AlaDH PNT family
M5E03_RS14905	COG1268	BioY protein
M5E03_RS14910	COG4326	sporulation control protein
M5E03_RS14915	COG2056	Na+-H+ antiporter family
M5E03_RS14920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M5E03_RS14925	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M5E03_RS14930	COG3584	3D domain protein
M5E03_RS14945	COG1252	NADH dehydrogenase
M5E03_RS14950	COG0492	ferredoxin-NADP+ reductase activity
M5E03_RS14960	COG0789	Transcriptional regulator
M5E03_RS14995	COG0316	Belongs to the HesB IscA family
M5E03_RS15000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M5E03_RS15005	COG4844	belongs to the
M5E03_RS15010	COG1252	NADH dehydrogenase
M5E03_RS15020	COG4837	Protein of unknown function (DUF1462)
M5E03_RS15030	COG1506	peptidase
M5E03_RS15030	COG4946	Tricorn protease homolog
M5E03_RS15030	COG0823	Involved in the tonB-independent uptake of proteins
M5E03_RS15035	COG0083	homoserine kinase activity
M5E03_RS15040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M5E03_RS15045	COG0460	homoserine dehydrogenase
M5E03_RS15050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E03_RS15055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E03_RS15060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5E03_RS15065	COG0647	UMP catabolic process
M5E03_RS15070	COG2445	Protein of unknown function DUF86
M5E03_RS15075	COG4470	Protein conserved in bacteria
M5E03_RS15085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5E03_RS15090	COG0739	heme binding
M5E03_RS15100	COG3377	Domain of unknown function (DUF1805)
M5E03_RS15105	COG0737	Belongs to the 5'-nucleotidase family
M5E03_RS15110	COG1801	Protein of unknown function DUF72
M5E03_RS15115	COG2508	Transcriptional regulator
M5E03_RS15120	COG2140	Oxalate decarboxylase
M5E03_RS15130	COG2814	Major facilitator Superfamily
M5E03_RS15135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M5E03_RS15140	COG2356	endonuclease I
M5E03_RS15150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_RS15155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_RS15160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_RS15175	COG0561	phosphatase activity
M5E03_RS15185	COG0642	Histidine kinase
M5E03_RS15185	COG5002	protein histidine kinase activity
M5E03_RS15190	COG0745	RESPONSE REGULATOR receiver
M5E03_RS15195	COG2311	Membrane
M5E03_RS15215	COG1309	transcriptional regulator
M5E03_RS15220	COG0719	Fe-S assembly protein
M5E03_RS15225	COG0822	iron-sulfur transferase activity
M5E03_RS15230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M5E03_RS15235	COG0719	Fe-S assembly protein
M5E03_RS15240	COG0396	ATPase activity
M5E03_RS15245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E03_RS15250	COG1464	Belongs to the NlpA lipoprotein family
M5E03_RS15255	COG2011	ABC-type metal ion transport system permease component
M5E03_RS15260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5E03_RS15270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_RS15275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M5E03_RS15285	COG0509	glycine decarboxylation via glycine cleavage system
M5E03_RS15290	COG1393	Belongs to the ArsC family
M5E03_RS15295	COG1960	acyl-CoA dehydrogenase activity
M5E03_RS15300	COG0183	Belongs to the thiolase family
M5E03_RS15305	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E03_RS15305	COG1024	Enoyl-CoA hydratase
M5E03_RS15320	COG5577	PFAM Coat F domain
M5E03_RS15330	COG1120	ATPase activity
M5E03_RS15340	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS15345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E03_RS15350	COG0745	RESPONSE REGULATOR receiver
M5E03_RS15355	COG2205	protein histidine kinase activity
M5E03_RS15355	COG2770	Histidine kinase
M5E03_RS15365	COG1309	transcriptional regulator
M5E03_RS15370	COG0114	fumarate hydratase activity
M5E03_RS15380	COG0697	spore germination
M5E03_RS15385	COG0814	amino acid
M5E03_RS15400	COG2197	response regulator
M5E03_RS15405	COG4585	Histidine kinase
M5E03_RS15410	COG4758	membrane
M5E03_RS15420	COG1842	Phage shock protein A
M5E03_RS15425	COG4758	membrane
M5E03_RS15430	COG2096	Adenosyltransferase
M5E03_RS15440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M5E03_RS15450	COG2204	response regulator
M5E03_RS15465	COG1454	alcohol dehydrogenase
M5E03_RS15470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E03_RS15475	COG1120	ATPase activity
M5E03_RS15480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_RS15485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_RS15495	COG2721	sulfolactate sulfo-lyase activity
M5E03_RS15500	COG0246	Mannitol dehydrogenase
M5E03_RS15505	COG1609	Transcriptional regulator
M5E03_RS15510	COG1904	glucuronate isomerase
M5E03_RS15515	COG2205	protein histidine kinase activity
M5E03_RS15520	COG0745	RESPONSE REGULATOR receiver
M5E03_RS15525	COG1120	ATPase activity
M5E03_RS15530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_RS15535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_RS15540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_RS15545	COG0531	amino acid
M5E03_RS15560	COG1988	membrane-bound metal-dependent
M5E03_RS15565	COG1368	sulfuric ester hydrolase activity
M5E03_RS15570	COG0725	ABC transporter, periplasmic molybdate-binding protein
M5E03_RS15575	COG4149	molybdate abc transporter
M5E03_RS15580	COG0656	L-ascorbic acid biosynthetic process
M5E03_RS15585	COG1940	carbohydrate kinase activity
M5E03_RS15590	COG0025	NhaP-type Na H and K H
M5E03_RS15595	COG2860	membrane
M5E03_RS15600	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M5E03_RS15605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5E03_RS15610	COG2217	Heavy metal translocating P-type atpase
M5E03_RS15615	COG1121	(ABC) transporter
M5E03_RS15620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5E03_RS15625	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5E03_RS15635	COG3226	Transcriptional regulator
M5E03_RS15640	COG0784	Response regulator, receiver
M5E03_RS15645	COG4191	Histidine kinase
M5E03_RS15650	COG1027	Aspartate ammonia-lyase
M5E03_RS15660	COG2217	Heavy metal translocating P-type atpase
M5E03_RS15665	COG2608	mercury ion transmembrane transporter activity
M5E03_RS15670	COG1937	Protein conserved in bacteria
M5E03_RS15695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M5E03_RS15700	COG0557	exoribonuclease II activity
M5E03_RS15705	COG1647	Serine aminopeptidase, S33
M5E03_RS15710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5E03_RS15715	COG2002	toxin-antitoxin pair type II binding
M5E03_RS15720	COG1476	TRANSCRIPTIONal
M5E03_RS15725	COG1396	sequence-specific DNA binding
M5E03_RS15730	COG1396	sequence-specific DNA binding
M5E03_RS15735	COG1733	regulation of RNA biosynthetic process
M5E03_RS15740	COG1174	glycine betaine transport
M5E03_RS15745	COG1732	Glycine betaine
M5E03_RS15750	COG1174	glycine betaine transport
M5E03_RS15755	COG0517	IMP dehydrogenase activity
M5E03_RS15755	COG1125	glycine betaine transport
M5E03_RS15760	COG1510	regulation of RNA biosynthetic process
M5E03_RS15765	COG2095	MarC family integral membrane protein
M5E03_RS15775	COG0456	acetyltransferase
M5E03_RS15795	COG1122	ATPase activity
M5E03_RS15805	COG0148	phosphopyruvate hydratase activity
M5E03_RS15810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M5E03_RS15815	COG0149	triose-phosphate isomerase activity
M5E03_RS15820	COG0126	phosphoglycerate kinase activity
M5E03_RS15825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5E03_RS15830	COG2390	Transcriptional regulator
M5E03_RS15835	COG0833	amino acid
M5E03_RS15840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E03_RS15845	COG3829	transcription factor binding
M5E03_RS15850	COG2186	Transcriptional regulator
M5E03_RS15855	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M5E03_RS15865	COG0534	Mate efflux family protein
M5E03_RS15875	COG0444	Belongs to the ABC transporter superfamily
M5E03_RS15880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_RS15885	COG0601	transmembrane transport
M5E03_RS15890	COG0747	negative chemotaxis
M5E03_RS15895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E03_RS15900	COG0110	maltose O-acetyltransferase activity
M5E03_RS15905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5E03_RS15910	COG2244	polysaccharide biosynthetic process
M5E03_RS15915	COG5039	Polysaccharide pyruvyl transferase
M5E03_RS15920	COG1216	Glycosyl transferase, family 2
M5E03_RS15930	COG0438	transferase activity, transferring glycosyl groups
M5E03_RS15935	COG1215	transferase activity, transferring glycosyl groups
M5E03_RS15940	COG0438	transferase activity, transferring glycosyl groups
M5E03_RS15945	COG1086	Polysaccharide biosynthesis protein
M5E03_RS15950	COG0489	protein tyrosine kinase activity
M5E03_RS15955	COG3944	biosynthesis protein
M5E03_RS15960	COG1396	sequence-specific DNA binding
M5E03_RS15970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_RS15975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_RS15980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_RS15985	COG0726	polysaccharide deacetylase
M5E03_RS15990	COG0488	(ABC) transporter
M5E03_RS16010	COG0601	transmembrane transport
M5E03_RS16015	COG0747	negative chemotaxis
M5E03_RS16020	COG1819	glycosyl
M5E03_RS16025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_RS16035	COG0740	serine-type endopeptidase activity
M5E03_RS16040	COG1611	Belongs to the LOG family
M5E03_RS16045	COG1694	Mazg nucleotide pyrophosphohydrolase
M5E03_RS16050	COG0659	secondary active sulfate transmembrane transporter activity
M5E03_RS16055	COG0288	reversible hydration of carbon dioxide
M5E03_RS16060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E03_RS16070	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M5E03_RS16075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS16080	COG1481	regulation of sporulation
M5E03_RS16085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M5E03_RS16090	COG1660	Displays ATPase and GTPase activities
M5E03_RS16095	COG1051	belongs to the nudix hydrolase family
M5E03_RS16100	COG0492	ferredoxin-NADP+ reductase activity
M5E03_RS16105	COG0791	NLP P60 protein
M5E03_RS16105	COG3883	PFAM NLP P60 protein
M5E03_RS16110	COG0457	Tetratricopeptide repeat
M5E03_RS16115	COG0140	phosphoribosyl-ATP diphosphatase activity
M5E03_RS16115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M5E03_RS16120	COG0107	imidazoleglycerol-phosphate synthase activity
M5E03_RS16125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M5E03_RS16130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M5E03_RS16135	COG0131	Imidazoleglycerol-phosphate dehydratase
M5E03_RS16140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M5E03_RS16145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M5E03_RS16150	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M5E03_RS16155	COG4990	cell redox homeostasis
M5E03_RS16170	COG2910	NAD(P)H-binding
M5E03_RS16175	COG1959	2 iron, 2 sulfur cluster binding
M5E03_RS16180	COG0110	maltose O-acetyltransferase activity
M5E03_RS16185	COG0546	phosphoglycolate phosphatase activity
M5E03_RS16190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M5E03_RS16200	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M5E03_RS16205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M5E03_RS16210	COG0363	glucosamine-6-phosphate deaminase activity
M5E03_RS16215	COG2188	Transcriptional regulator
M5E03_RS16220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M5E03_RS16225	COG1950	PFAM Membrane protein of
M5E03_RS16230	COG1983	PspC domain protein
M5E03_RS16235	COG3595	metallopeptidase activity
M5E03_RS16250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5E03_RS16260	COG4897	Protein conserved in bacteria
M5E03_RS16265	COG0574	Belongs to the PEP-utilizing enzyme family
M5E03_RS16265	COG3848	Pyruvate phosphate dikinase
M5E03_RS16270	COG1309	transcriptional regulator
M5E03_RS16275	COG2814	Major facilitator Superfamily
M5E03_RS16285	COG0745	RESPONSE REGULATOR receiver
M5E03_RS16290	COG5002	protein histidine kinase activity
M5E03_RS16295	COG1113	amino acid transport
M5E03_RS16300	COG0778	Nitroreductase
M5E03_RS16305	COG1733	regulation of RNA biosynthetic process
M5E03_RS16310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E03_RS16320	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_RS16320	COG0793	Belongs to the peptidase S41A family
M5E03_RS16325	COG0730	response to heat
M5E03_RS16330	COG0791	NLP P60 protein
M5E03_RS16330	COG3883	PFAM NLP P60 protein
M5E03_RS16335	COG2177	Part of the ABC transporter FtsEX involved in
M5E03_RS16340	COG2884	Cell division ATP-binding protein ftsE
M5E03_RS16345	COG2010	Cytochrome c
M5E03_RS16350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_RS16370	COG0653	protein targeting
M5E03_RS16375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5E03_RS16380	COG0840	transmembrane signaling receptor activity
M5E03_RS16395	COG1516	flagellar protein fliS
M5E03_RS16400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M5E03_RS16405	COG1334	flagellar protein FlaG
M5E03_RS16410	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M5E03_RS16415	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
M5E03_RS16425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E03_RS16430	COG1256	bacterial-type flagellum assembly
M5E03_RS16430	COG4786	Flagellar basal body rod
M5E03_RS16435	COG3418	PFAM FlgN family protein
M5E03_RS16450	COG1040	competence protein
M5E03_RS16460	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M5E03_RS16465	COG1307	EDD domain protein, DegV family
M5E03_RS16470	COG2197	response regulator
M5E03_RS16475	COG4585	Histidine kinase
M5E03_RS16480	COG1739	Uncharacterized protein family UPF0029
M5E03_RS16485	COG1316	TRANSCRIPTIONal
M5E03_RS16490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5E03_RS16495	COG0438	transferase activity, transferring glycosyl groups
M5E03_RS16500	COG1215	transferase activity, transferring glycosyl groups
M5E03_RS16505	COG3206	protein involved in exopolysaccharide biosynthesis
M5E03_RS16510	COG3307	-O-antigen
M5E03_RS16515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E03_RS16520	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M5E03_RS16525	COG0297	glycogen (starch) synthase activity
M5E03_RS16525	COG0438	transferase activity, transferring glycosyl groups
M5E03_RS16530	COG2244	polysaccharide biosynthetic process
M5E03_RS16545	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_RS16545	COG2247	cell wall binding repeat
M5E03_RS16550	COG2247	cell wall binding repeat
M5E03_RS16550	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_RS16555	COG2247	cell wall binding repeat
M5E03_RS16555	COG2385	sporulation resulting in formation of a cellular spore
M5E03_RS16565	COG1316	TRANSCRIPTIONal
M5E03_RS16570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M5E03_RS16575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M5E03_RS16580	COG1134	teichoic acid transport
M5E03_RS16585	COG1682	transport, permease protein
M5E03_RS16590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E03_RS16595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E03_RS16605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M5E03_RS16610	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M5E03_RS16615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E03_RS16620	COG4193	domain, Protein
M5E03_RS16625	COG1482	cell wall glycoprotein biosynthetic process
M5E03_RS16635	COG1175	transmembrane transport
M5E03_RS16640	COG1653	transport
M5E03_RS16645	COG2197	response regulator
M5E03_RS16650	COG2972	Histidine kinase
M5E03_RS16660	COG0454	-acetyltransferase
M5E03_RS16665	COG0800	Aldolase
M5E03_RS16670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5E03_RS16675	COG1609	Transcriptional regulator
M5E03_RS16680	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M5E03_RS16685	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS16690	COG0697	spore germination
M5E03_RS16695	COG0814	amino acid
M5E03_RS16710	COG2814	Major facilitator Superfamily
M5E03_RS16715	COG1316	TRANSCRIPTIONal
M5E03_RS16720	COG0561	phosphatase activity
M5E03_RS16725	COG0791	NLP P60 protein
M5E03_RS16735	COG2843	Capsule synthesis protein
M5E03_RS16750	COG0697	spore germination
M5E03_RS16765	COG1609	Transcriptional regulator
M5E03_RS16770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5E03_RS16775	COG1869	D-ribose catabolic process
M5E03_RS16780	COG1129	ABC transporter
M5E03_RS16785	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5E03_RS16790	COG1879	ABC-type sugar transport system periplasmic component
M5E03_RS16795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E03_RS16800	COG0583	DNA-binding transcription factor activity
M5E03_RS16805	COG0028	Belongs to the TPP enzyme family
M5E03_RS16810	COG3527	Alpha-acetolactate decarboxylase
M5E03_RS16815	COG1522	sequence-specific DNA binding
M5E03_RS16820	COG2059	Chromate
M5E03_RS16825	COG2059	Chromate
M5E03_RS16830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M5E03_RS16840	COG4715	Zinc finger, swim domain protein
M5E03_RS16845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5E03_RS16850	COG2202	Pas domain
M5E03_RS16850	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_RS16855	COG0561	phosphatase activity
M5E03_RS16870	COG1970	mechanosensitive ion channel activity
M5E03_RS16875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5E03_RS16880	COG0457	Tetratricopeptide repeat
M5E03_RS16885	COG4786	Flagellar basal body rod
M5E03_RS16890	COG4786	Flagellar basal body rod
M5E03_RS16895	COG1077	Cell shape determining protein MreB Mrl
M5E03_RS16900	COG1609	Transcriptional regulator
M5E03_RS16905	COG1846	Transcriptional regulator
M5E03_RS16910	COG2814	Major facilitator Superfamily
M5E03_RS16915	COG0671	phosphoesterase, PA-phosphatase related
M5E03_RS16920	COG0477	Major facilitator Superfamily
M5E03_RS16925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_RS16930	COG0765	amino acid transport
M5E03_RS16940	COG0004	ammonium transporteR
M5E03_RS16945	COG0347	Belongs to the P(II) protein family
M5E03_RS16950	COG0739	heme binding
M5E03_RS16955	COG1247	-acetyltransferase
M5E03_RS16970	COG0523	cobalamin synthesis protein
M5E03_RS16975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5E03_RS16980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5E03_RS16985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M5E03_RS16990	COG2223	nitrite transmembrane transporter activity
M5E03_RS16995	COG0243	molybdopterin cofactor binding
M5E03_RS17000	COG2304	oxidoreductase activity
M5E03_RS17005	COG2304	oxidoreductase activity
M5E03_RS17010	COG2385	sporulation resulting in formation of a cellular spore
M5E03_RS17015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5E03_RS17025	COG4836	Membrane
M5E03_RS17035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M5E03_RS17040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M5E03_RS17045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M5E03_RS17050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M5E03_RS17055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5E03_RS17060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M5E03_RS17065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5E03_RS17070	COG0356	it plays a direct role in the translocation of protons across the membrane
M5E03_RS17080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M5E03_RS17085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5E03_RS17090	COG4475	Protein of unknown function (DUF436)
M5E03_RS17095	COG0698	ribose 5-phosphate isomerase
M5E03_RS17100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5E03_RS17105	COG1971	Probably functions as a manganese efflux pump
M5E03_RS17110	COG0009	L-threonylcarbamoyladenylate synthase
M5E03_RS17115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5E03_RS17130	COG2890	protein-(glutamine-N5) methyltransferase activity
M5E03_RS17135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M5E03_RS17140	COG0789	Transcriptional regulator
M5E03_RS17145	COG0679	Auxin Efflux Carrier
M5E03_RS17150	COG0281	malic enzyme
M5E03_RS17155	COG1435	thymidine kinase activity
M5E03_RS17160	COG0254	rRNA binding
M5E03_RS17165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M5E03_RS17170	COG1494	fructose-1,6-bisphosphatase
M5E03_RS17175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5E03_RS17180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5E03_RS17185	COG0191	fructose-bisphosphate aldolase activity
M5E03_RS17190	COG2204	response regulator
M5E03_RS17195	COG4821	SIS domain
M5E03_RS17200	COG0504	CTP synthase activity
M5E03_RS17205	COG3343	RNA polymerase activity
M5E03_RS17215	COG1960	acyl-CoA dehydrogenase activity
M5E03_RS17220	COG1960	acyl-CoA dehydrogenase activity
M5E03_RS17225	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E03_RS17230	COG0183	Belongs to the thiolase family
M5E03_RS17235	COG0247	lactate metabolic process
M5E03_RS17235	COG2181	nitrate reductase activity
M5E03_RS17240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E03_RS17245	COG4294	response to UV
M5E03_RS17255	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5E03_RS17265	COG1132	(ABC) transporter
M5E03_RS17270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E03_RS17275	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5E03_RS17285	COG0018	arginyl-trna synthetase
M5E03_RS17290	COG4506	Protein conserved in bacteria
M5E03_RS17300	COG0010	Belongs to the arginase family
M5E03_RS17305	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M5E03_RS17310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E03_RS17320	COG1994	Peptidase M50
M5E03_RS17325	COG1942	4-Oxalocrotonate Tautomerase
M5E03_RS17355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_RS17360	COG0583	DNA-binding transcription factor activity
M5E03_RS17365	COG0431	NADPH-dependent FMN reductase
M5E03_RS17370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_RS17375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5E03_RS17380	COG0454	-acetyltransferase
M5E03_RS17385	COG0765	amino acid transport
M5E03_RS17390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_RS17395	COG0765	amino acid transport
M5E03_RS17400	COG1126	abc transporter atp-binding protein
M5E03_RS17405	COG3465	dGTPase activity
M5E03_RS17410	COG1078	dGTPase activity
M5E03_RS17415	COG4844	belongs to the
M5E03_RS17495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M5E03_RS17505	COG0280	phosphate acetyltransferase
M5E03_RS17515	COG1073	alpha beta
M5E03_RS17520	COG1522	sequence-specific DNA binding
M5E03_RS17525	COG2814	Major facilitator Superfamily
M5E03_RS17530	COG0077	Prephenate dehydratase
M5E03_RS17540	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS17545	COG0151	Belongs to the GarS family
M5E03_RS17550	COG0436	Aminotransferase
M5E03_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS17560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M5E03_RS17565	COG1091	dTDP-4-dehydrorhamnose reductase activity
M5E03_RS17570	COG1088	dTDP-glucose 4,6-dehydratase activity
M5E03_RS17575	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M5E03_RS17580	COG3980	spore coat polysaccharide biosynthesis protein
M5E03_RS17585	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M5E03_RS17590	COG2089	acid synthase
M5E03_RS17595	COG0456	acetyltransferase
M5E03_RS17600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E03_RS17605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E03_RS17610	COG0463	Glycosyl transferase, family 2
M5E03_RS17630	COG2363	Small membrane protein
M5E03_RS17635	COG2233	PERMEase
M5E03_RS17645	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_RS17650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M5E03_RS17655	COG1216	Glycosyl transferase, family 2
M5E03_RS17665	COG0351	phosphomethylpyrimidine kinase
M5E03_RS17680	COG1621	beta-fructofuranosidase activity
M5E03_RS17685	COG1263	PTS System
M5E03_RS17685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS17690	COG3711	transcriptional antiterminator
M5E03_RS17700	COG1404	Belongs to the peptidase S8 family
M5E03_RS17705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_RS17710	COG0778	Nitroreductase
M5E03_RS17715	COG0772	Belongs to the SEDS family
M5E03_RS17725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5E03_RS17730	COG1845	cytochrome c oxidase, subunit III
M5E03_RS17735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5E03_RS17740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5E03_RS17750	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M5E03_RS17755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5E03_RS17760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M5E03_RS17775	COG2246	polysaccharide biosynthetic process
M5E03_RS17795	COG3162	membrane
M5E03_RS17800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E03_RS17810	COG0352	thiamine-phosphate diphosphorylase activity
M5E03_RS17815	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M5E03_RS17820	COG0583	DNA-binding transcription factor activity
M5E03_RS17825	COG1380	Effector of murein hydrolase LrgA
M5E03_RS17830	COG1346	cytolysis
M5E03_RS17835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5E03_RS17840	COG0346	lactoylglutathione lyase activity
M5E03_RS17850	COG0765	amino acid transport
M5E03_RS17855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_RS17860	COG0457	Tetratricopeptide repeat
M5E03_RS17870	COG2357	RelA SpoT domain protein
M5E03_RS17875	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5E03_RS17880	COG1129	ABC transporter
M5E03_RS17890	COG3420	alginic acid biosynthetic process
M5E03_RS17895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E03_RS17905	COG1486	melibiose metabolic process
M5E03_RS17910	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5E03_RS17915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_RS17920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_RS17925	COG3711	transcriptional antiterminator
M5E03_RS17925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS17945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E03_RS17960	COG1595	DNA-templated transcription, initiation
M5E03_RS17970	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M5E03_RS17975	COG4988	ABC transporter
M5E03_RS17980	COG1294	oxidase, subunit
M5E03_RS17985	COG1271	oxidase subunit
M5E03_RS18010	COG4509	Sortase family
M5E03_RS18035	COG5386	Cell surface protein
M5E03_RS18040	COG5386	Cell surface protein
M5E03_RS18045	COG1733	regulation of RNA biosynthetic process
M5E03_RS18050	COG2514	catechol 2,3-dioxygenase activity
M5E03_RS18055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E03_RS18055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E03_RS18060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E03_RS18060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E03_RS18070	COG0726	polysaccharide deacetylase
M5E03_RS18075	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5E03_RS18080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_RS18085	COG2723	6-phospho-beta-galactosidase activity
M5E03_RS18090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_RS18095	COG3711	transcriptional antiterminator
M5E03_RS18095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_RS18120	COG1757	Na H antiporter
M5E03_RS18125	COG1027	Aspartate ammonia-lyase
M5E03_RS18130	COG0252	asparaginase activity
M5E03_RS18135	COG1396	sequence-specific DNA binding
M5E03_RS18160	COG4842	Belongs to the WXG100 family
M5E03_RS18165	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5E03_RS18180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5E03_RS18185	COG2723	6-phospho-beta-galactosidase activity
M5E03_RS18190	COG1263	PTS System
M5E03_RS18190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS18190	COG2190	(PTS) system
M5E03_RS18195	COG3711	transcriptional antiterminator
M5E03_RS18200	COG3878	Protein conserved in bacteria
M5E03_RS18210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5E03_RS18215	COG1122	ATPase activity
M5E03_RS18220	COG4721	ABC-type cobalt transport system, permease component
M5E03_RS18225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E03_RS18260	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M5E03_RS18265	COG0778	Nitroreductase
M5E03_RS18275	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M5E03_RS18280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5E03_RS18285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M5E03_RS18290	COG2390	Transcriptional regulator
M5E03_RS18300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M5E03_RS18300	COG2755	lipolytic protein G-D-S-L family
M5E03_RS18320	COG0561	phosphatase activity
M5E03_RS18325	COG0789	Transcriptional regulator
M5E03_RS18330	COG0673	inositol 2-dehydrogenase activity
M5E03_RS18335	COG0840	transmembrane signaling receptor activity
M5E03_RS18340	COG1113	amino acid transport
M5E03_RS18345	COG4335	DNA alkylation repair
M5E03_RS18355	COG1070	Carbohydrate kinase
M5E03_RS18360	COG1737	Transcriptional regulator
M5E03_RS18380	COG0583	DNA-binding transcription factor activity
M5E03_RS18385	COG1609	Transcriptional regulator
M5E03_RS18390	COG2182	Extracellular solute-binding protein
M5E03_RS18395	COG1175	transmembrane transport
M5E03_RS18400	COG3833	ABC-type maltose transport systems, permease component
M5E03_RS18410	COG1874	Beta-galactosidase
M5E03_RS18415	COG2851	Citrate transporter
M5E03_RS18425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M5E03_RS18430	COG1131	(ABC) transporter
M5E03_RS18435	COG2824	Alkylphosphonate utilization operon protein PhnA
M5E03_RS18440	COG1929	Belongs to the glycerate kinase type-1 family
M5E03_RS18445	COG2610	gluconate transmembrane transporter activity
M5E03_RS18450	COG3835	regulator
M5E03_RS18455	COG1309	transcriptional regulator
M5E03_RS18460	COG2814	Major facilitator Superfamily
M5E03_RS18470	COG1136	(ABC) transporter
M5E03_RS18470	COG0577	efflux transmembrane transporter activity
M5E03_RS18475	COG0457	Tetratricopeptide repeat
M5E03_RS18480	COG3711	transcriptional antiterminator
M5E03_RS18485	COG2723	6-phospho-beta-galactosidase activity
M5E03_RS18490	COG2190	(PTS) system
M5E03_RS18490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_RS18490	COG1263	PTS System
M5E03_RS18525	COG1113	amino acid transport
M5E03_RS18530	COG1609	Transcriptional regulator
M5E03_RS18535	COG2814	Major facilitator Superfamily
M5E03_RS18545	COG2814	Major facilitator Superfamily
M5E03_RS18565	COG5444	nuclease activity
M5E03_RS18580	COG2723	6-phospho-beta-galactosidase activity
M5E03_RS18590	COG2188	Transcriptional regulator
M5E03_RS18600	COG0384	phenazine biosynthesis protein PhzF
M5E03_RS18605	COG0583	DNA-binding transcription factor activity
M5E03_RS18625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5E03_RS18635	COG2814	Major facilitator Superfamily
M5E03_RS18640	COG0640	Transcriptional regulator
M5E03_RS18660	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M5E03_RS18670	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5E03_RS18680	COG4720	Psort location CytoplasmicMembrane, score
M5E03_RS18700	COG0456	acetyltransferase
M5E03_RS18705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E03_RS18710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M5E03_RS18715	COG4853	Protein conserved in bacteria
M5E03_RS18720	COG4863	YycH protein
M5E03_RS18725	COG5002	protein histidine kinase activity
M5E03_RS18730	COG0745	RESPONSE REGULATOR receiver
M5E03_RS18755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_RS18765	COG2311	Membrane
M5E03_RS18770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5E03_RS18775	COG0346	lactoylglutathione lyase activity
M5E03_RS18780	COG0305	Participates in initiation and elongation during chromosome replication
M5E03_RS18800	COG2819	hydrolase of the alpha beta superfamily
M5E03_RS18805	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_RS18810	COG1169	isochorismate synthase
M5E03_RS18815	COG1021	2,3-dihydroxybenzoate-AMP ligase
M5E03_RS18820	COG1535	isochorismatase
M5E03_RS18820	COG3433	isochorismatase activity
M5E03_RS18825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E03_RS18830	COG3251	PFAM MbtH domain protein
M5E03_RS18835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_RS18835	COG2207	Transcriptional regulator
M5E03_RS18840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_RS18845	COG2819	hydrolase of the alpha beta superfamily
M5E03_RS18850	COG3093	addiction module antidote protein HigA
M5E03_RS18855	COG2807	transmembrane transport
M5E03_RS18860	COG0359	binds to the 23S rRNA
M5E03_RS18865	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M5E03_RS18870	COG4241	membrane
M5E03_RS18875	COG1227	inorganic diphosphatase activity
M5E03_RS18885	COG1595	DNA-templated transcription, initiation
M5E03_RS18895	COG0753	catalase activity
M5E03_RS18900	COG0655	NAD(P)H dehydrogenase (quinone) activity
M5E03_RS18905	COG0400	carboxylic ester hydrolase activity
M5E03_RS18910	COG0346	lactoylglutathione lyase activity
M5E03_RS18915	COG1174	glycine betaine transport
M5E03_RS18920	COG0517	IMP dehydrogenase activity
M5E03_RS18920	COG1125	glycine betaine transport
M5E03_RS18925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M5E03_RS18930	COG0629	single-stranded DNA binding
M5E03_RS18935	COG0360	Binds together with S18 to 16S ribosomal RNA
M5E03_RS18940	COG0012	GTP binding
M5E03_RS18945	COG4481	Protein conserved in bacteria
M5E03_RS18960	COG3949	Membrane
M5E03_RS18970	COG1475	DNA binding
M5E03_RS18975	COG1192	Involved in chromosome partitioning
M5E03_RS18980	COG1475	DNA binding
M5E03_RS18985	COG0357	Ribosomal RNA small subunit methyltransferase G
M5E03_RS18990	COG0445	tRNA wobble uridine modification
M5E03_RS18995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M5E03_RS19000	COG1847	R3H domain protein
M5E03_RS19005	COG0706	membrane insertase activity
M5E03_RS19010	COG0594	ribonuclease P activity
M5E03_RS19015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M5E03_RS19040	COG0457	Tetratricopeptide repeat