locus-tag	class	description
LXN49_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LXN49_RS00015	COG0592	DNA-directed DNA polymerase activity
LXN49_RS00020	COG2501	S4 domain
LXN49_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LXN49_RS00035	COG0187	DNA topoisomerase II activity
LXN49_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LXN49_RS00075	COG0516	GMP reductase activity
LXN49_RS00075	COG0517	IMP dehydrogenase activity
LXN49_RS00080	COG1686	Belongs to the peptidase S11 family
LXN49_RS00085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXN49_RS00090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LXN49_RS00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LXN49_RS00100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LXN49_RS00115	COG1428	Deoxynucleoside kinase
LXN49_RS00120	COG1428	Deoxynucleoside kinase
LXN49_RS00125	COG3858	chitin binding
LXN49_RS00125	COG1388	LysM domain
LXN49_RS00130	COG1335	isochorismatase
LXN49_RS00135	COG0590	tRNA wobble adenosine to inosine editing
LXN49_RS00145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LXN49_RS00150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LXN49_RS00155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LXN49_RS00200	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
LXN49_RS00205	COG3853	Toxic anion resistance protein (TelA)
LXN49_RS00210	COG1982	Orn Lys Arg decarboxylase major
LXN49_RS00215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LXN49_RS00220	COG3870	Protein conserved in bacteria
LXN49_RS00225	COG1728	Protein conserved in bacteria
LXN49_RS00230	COG0470	DNA polymerase III
LXN49_RS00235	COG1774	PSP1 C-terminal conserved region
LXN49_RS00240	COG4467	Involved in initiation control of chromosome replication
LXN49_RS00245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LXN49_RS00250	COG2827	Endonuclease containing a URI domain
LXN49_RS00255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LXN49_RS00260	COG2002	toxin-antitoxin pair type II binding
LXN49_RS00265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LXN49_RS00265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LXN49_RS00270	COG0084	hydrolase, TatD family'
LXN49_RS00275	COG3583	domain protein
LXN49_RS00275	COG3584	3D domain protein
LXN49_RS00280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LXN49_RS00285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LXN49_RS00295	COG4466	Protein conserved in bacteria
LXN49_RS00305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LXN49_RS00310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LXN49_RS00315	COG0251	oxidation-reduction process
LXN49_RS00320	COG2088	sporulation resulting in formation of a cellular spore
LXN49_RS00330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LXN49_RS00335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LXN49_RS00340	COG0193	aminoacyl-tRNA hydrolase activity
LXN49_RS00350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LXN49_RS00355	COG2002	toxin-antitoxin pair type II binding
LXN49_RS00360	COG2244	polysaccharide biosynthetic process
LXN49_RS00365	COG3956	TIGRFAM MazG family protein
LXN49_RS00370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LXN49_RS00385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LXN49_RS00390	COG1098	S1 RNA binding domain
LXN49_RS00405	COG2208	phosphoserine phosphatase activity
LXN49_RS00410	COG2304	oxidoreductase activity
LXN49_RS00415	COG0515	serine threonine protein kinase
LXN49_RS00420	COG0037	tRNA processing
LXN49_RS00425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LXN49_RS00430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LXN49_RS00435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LXN49_RS00440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LXN49_RS00445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LXN49_RS00450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LXN49_RS00455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LXN49_RS00460	COG0512	Glutamine amidotransferase of anthranilate synthase
LXN49_RS00465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LXN49_RS00470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LXN49_RS00475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LXN49_RS00480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LXN49_RS00485	COG1396	sequence-specific DNA binding
LXN49_RS00490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LXN49_RS00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LXN49_RS00575	COG4463	regulation of RNA biosynthetic process
LXN49_RS00580	COG3880	PFAM UvrB UvrC protein
LXN49_RS00585	COG3869	Catalyzes the specific phosphorylation of arginine residues in
LXN49_RS00590	COG0542	response to heat
LXN49_RS00595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LXN49_RS00600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LXN49_RS00605	COG4956	integral membrane protein (PIN domain superfamily)
LXN49_RS00610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LXN49_RS00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LXN49_RS00620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LXN49_RS00625	COG1045	serine acetyltransferase
LXN49_RS00630	COG0215	cysteine-tRNA ligase activity
LXN49_RS00635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LXN49_RS00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LXN49_RS00645	COG3688	RNA-binding protein containing a PIN domain
LXN49_RS00650	COG1595	DNA-templated transcription, initiation
LXN49_RS00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LXN49_RS00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LXN49_RS00665	COG0250	Participates in transcription elongation, termination and antitermination
LXN49_RS00675	COG0081	regulation of translation
LXN49_RS00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LXN49_RS00685	COG0222	ribosome binding
LXN49_RS00690	COG2813	Specifically methylates the guanine in position
LXN49_RS00695	COG0085	RNA polymerase activity
LXN49_RS00700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LXN49_RS00705	COG1358	cellular component organization or biogenesis
LXN49_RS00710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LXN49_RS00715	COG0049	tRNA binding
LXN49_RS00720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LXN49_RS00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LXN49_RS00730	COG0596	Alpha beta hydrolase
LXN49_RS00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LXN49_RS00745	COG0088	Forms part of the polypeptide exit tunnel
LXN49_RS00750	COG0089	rRNA binding
LXN49_RS00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LXN49_RS00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LXN49_RS00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LXN49_RS00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LXN49_RS00780	COG0255	Belongs to the universal ribosomal protein uL29 family
LXN49_RS00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LXN49_RS00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LXN49_RS00795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LXN49_RS00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LXN49_RS00805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LXN49_RS00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LXN49_RS00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LXN49_RS00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LXN49_RS00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LXN49_RS00830	COG1841	ribosomal large subunit assembly
LXN49_RS00835	COG0200	Binds to the 23S rRNA
LXN49_RS00840	COG0201	protein transport
LXN49_RS00845	COG0563	adenylate kinase activity
LXN49_RS00850	COG0024	Methionine aminopeptidase
LXN49_RS00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LXN49_RS00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LXN49_RS00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LXN49_RS00875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LXN49_RS00880	COG0202	RNA polymerase activity
LXN49_RS00885	COG0203	ribosomal protein L17
LXN49_RS00890	COG1122	ATPase activity
LXN49_RS00895	COG1122	ATPase activity
LXN49_RS00900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LXN49_RS00905	COG0101	tRNA pseudouridine synthase activity
LXN49_RS00910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LXN49_RS00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LXN49_RS00920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LXN49_RS00945	COG0860	N-Acetylmuramoyl-L-alanine amidase
LXN49_RS00950	COG0489	protein tyrosine kinase activity
LXN49_RS00960	COG2194	sulfuric ester hydrolase activity
LXN49_RS00965	COG0726	polysaccharide deacetylase
LXN49_RS00995	COG0659	secondary active sulfate transmembrane transporter activity
LXN49_RS01000	COG0385	Bile acid
LXN49_RS01005	COG3876	Protein conserved in bacteria
LXN49_RS01010	COG1472	Belongs to the glycosyl hydrolase 3 family
LXN49_RS01015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXN49_RS01020	COG1263	PTS System
LXN49_RS01020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS01025	COG1737	Transcriptional regulator
LXN49_RS01030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LXN49_RS01065	COG1595	DNA-templated transcription, initiation
LXN49_RS01070	COG5662	AntiSigma factor
LXN49_RS01075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LXN49_RS01080	COG4856	YbbR-like protein
LXN49_RS01085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LXN49_RS01090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LXN49_RS01110	COG1131	(ABC) transporter
LXN49_RS01125	COG1131	(ABC) transporter
LXN49_RS01135	COG1413	lyase activity
LXN49_RS01145	COG2311	Membrane
LXN49_RS01165	COG1113	amino acid transport
LXN49_RS01170	COG0584	glycerophosphoryl diester phosphodiesterase
LXN49_RS01175	COG2271	Major facilitator Superfamily
LXN49_RS01185	COG1331	Highly conserved protein containing a thioredoxin domain
LXN49_RS01190	COG1331	Highly conserved protein containing a thioredoxin domain
LXN49_RS01195	COG0697	spore germination
LXN49_RS01200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXN49_RS01210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LXN49_RS01230	COG1937	Protein conserved in bacteria
LXN49_RS01235	COG2210	Belongs to the sulfur carrier protein TusA family
LXN49_RS01245	COG0425	Belongs to the sulfur carrier protein TusA family
LXN49_RS01245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LXN49_RS01250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LXN49_RS01250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LXN49_RS01255	COG0425	Belongs to the sulfur carrier protein TusA family
LXN49_RS01260	COG0730	response to heat
LXN49_RS01270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LXN49_RS01275	COG2814	Major facilitator Superfamily
LXN49_RS01285	COG1846	Transcriptional regulator
LXN49_RS01295	COG1683	Conserved Protein
LXN49_RS01305	COG0656	L-ascorbic acid biosynthetic process
LXN49_RS01310	COG0371	Dehydrogenase
LXN49_RS01315	COG1054	Belongs to the UPF0176 family
LXN49_RS01320	COG0531	amino acid
LXN49_RS01330	COG3711	transcriptional antiterminator
LXN49_RS01335	COG1263	PTS System
LXN49_RS01335	COG2190	(PTS) system
LXN49_RS01335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS01340	COG2723	6-phospho-beta-galactosidase activity
LXN49_RS01360	COG3711	transcriptional antiterminator
LXN49_RS01360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS01365	COG1940	carbohydrate kinase activity
LXN49_RS01370	COG0383	alpha-mannosidase activity
LXN49_RS01375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXN49_RS01380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXN49_RS01390	COG1404	Belongs to the peptidase S8 family
LXN49_RS01400	COG0833	amino acid
LXN49_RS01405	COG2040	homocysteine
LXN49_RS01410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LXN49_RS01415	COG1695	Transcriptional regulator
LXN49_RS01430	COG2814	Major facilitator Superfamily
LXN49_RS01435	COG0456	acetyltransferase
LXN49_RS01450	COG1404	Belongs to the peptidase S8 family
LXN49_RS01460	COG1309	transcriptional regulator
LXN49_RS01465	COG1917	Cupin 2, conserved barrel domain protein
LXN49_RS01470	COG1063	alcohol dehydrogenase
LXN49_RS01475	COG1846	Transcriptional regulator
LXN49_RS01480	COG0318	PFAM AMP-dependent synthetase and ligase
LXN49_RS01485	COG0531	amino acid
LXN49_RS01495	COG0596	Alpha beta hydrolase
LXN49_RS01500	COG1115	amino acid carrier protein
LXN49_RS01505	COG2066	Belongs to the glutaminase family
LXN49_RS01510	COG4191	Histidine kinase
LXN49_RS01515	COG0784	Response regulator, receiver
LXN49_RS01520	COG1405	negative regulation of cell septum assembly
LXN49_RS01520	COG3012	SEC-C Motif Domain Protein
LXN49_RS01530	COG2197	response regulator
LXN49_RS01535	COG4585	Histidine kinase
LXN49_RS01545	COG0667	Aldo Keto reductase
LXN49_RS01550	COG3290	protein histidine kinase activity
LXN49_RS01555	COG3279	Response regulator of the LytR AlgR family
LXN49_RS01560	COG4555	ABC transporter
LXN49_RS01565	COG1668	transmembrane transport
LXN49_RS01580	COG3773	Cell wall hydrolase
LXN49_RS01585	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS01595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXN49_RS01600	COG2310	stress, protein
LXN49_RS01605	COG2310	stress, protein
LXN49_RS01610	COG2310	stress, protein
LXN49_RS01615	COG0861	Integral membrane protein TerC family
LXN49_RS01645	COG3853	Toxic anion resistance protein (TelA)
LXN49_RS01650	COG0517	IMP dehydrogenase activity
LXN49_RS01650	COG4175	Glycine betaine
LXN49_RS01655	COG4176	ABC-type proline glycine betaine transport system permease component
LXN49_RS01660	COG2113	Glycine betaine
LXN49_RS01675	COG1473	amidohydrolase
LXN49_RS01680	COG1288	antiporter activity
LXN49_RS01685	COG0039	L-malate dehydrogenase activity
LXN49_RS01690	COG1620	l-lactate permease
LXN49_RS01695	COG1609	Transcriptional regulator
LXN49_RS01700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LXN49_RS01705	COG0561	phosphatase activity
LXN49_RS01710	COG0673	inositol 2-dehydrogenase activity
LXN49_RS01715	COG0738	Major facilitator superfamily
LXN49_RS01720	COG1280	lysine exporter protein (LysE YggA)
LXN49_RS01730	COG3403	YqcI/YcgG family
LXN49_RS01735	COG1113	amino acid transport
LXN49_RS01740	COG3665	Urea carboxylase-associated protein
LXN49_RS01745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LXN49_RS01755	COG1012	belongs to the aldehyde dehydrogenase family
LXN49_RS01760	COG0710	3-dehydroquinate dehydratase activity
LXN49_RS01765	COG0028	Belongs to the TPP enzyme family
LXN49_RS01775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LXN49_RS01780	COG2271	Major facilitator Superfamily
LXN49_RS01795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LXN49_RS01800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXN49_RS01810	COG0477	Major facilitator Superfamily
LXN49_RS01815	COG2226	methyltransferase
LXN49_RS01820	COG0583	DNA-binding transcription factor activity
LXN49_RS01825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LXN49_RS01830	COG3458	cephalosporin-C deacetylase activity
LXN49_RS01840	COG3541	Predicted nucleotidyltransferase
LXN49_RS01845	COG0506	proline dehydrogenase activity
LXN49_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
LXN49_RS01855	COG2508	Transcriptional regulator
LXN49_RS01860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LXN49_RS01865	COG0765	amino acid transport
LXN49_RS01870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXN49_RS01880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LXN49_RS01885	COG1522	sequence-specific DNA binding
LXN49_RS01890	COG2746	aminoglycoside 3-N-acetyltransferase activity
LXN49_RS01900	COG0840	transmembrane signaling receptor activity
LXN49_RS01900	COG3290	protein histidine kinase activity
LXN49_RS01905	COG3209	COG3209 Rhs family protein
LXN49_RS01925	COG3842	ATPase activity
LXN49_RS01940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LXN49_RS01945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LXN49_RS01950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LXN49_RS01965	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
LXN49_RS01970	COG0697	spore germination
LXN49_RS01975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXN49_RS01990	COG2364	Membrane
LXN49_RS01995	COG1126	abc transporter atp-binding protein
LXN49_RS02000	COG0765	amino acid transport
LXN49_RS02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXN49_RS02010	COG0833	amino acid
LXN49_RS02020	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS02025	COG1312	Catalyzes the dehydration of D-mannonate
LXN49_RS02030	COG1802	Transcriptional regulator
LXN49_RS02035	COG0673	inositol 2-dehydrogenase activity
LXN49_RS02045	COG1904	glucuronate isomerase
LXN49_RS02050	COG3104	oligopeptide transport
LXN49_RS02055	COG5434	Belongs to the glycosyl hydrolase 28 family
LXN49_RS02060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXN49_RS02065	COG0456	acetyltransferase
LXN49_RS02070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXN49_RS02075	COG0765	amino acid transport
LXN49_RS02080	COG1126	abc transporter atp-binding protein
LXN49_RS02085	COG1473	amidohydrolase
LXN49_RS02090	COG2079	MmgE PrpD family protein
LXN49_RS02095	COG0745	RESPONSE REGULATOR receiver
LXN49_RS02100	COG3850	Histidine kinase
LXN49_RS02100	COG5002	protein histidine kinase activity
LXN49_RS02105	COG1366	Belongs to the anti-sigma-factor antagonist family
LXN49_RS02110	COG0527	aspartate kinase activity
LXN49_RS02115	COG2814	Major facilitator Superfamily
LXN49_RS02120	COG1309	transcriptional regulator
LXN49_RS02130	COG0640	Transcriptional regulator
LXN49_RS02135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXN49_RS02140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LXN49_RS02145	COG0531	amino acid
LXN49_RS02150	COG1012	belongs to the aldehyde dehydrogenase family
LXN49_RS02155	COG2249	NAD(P)H dehydrogenase (quinone) activity
LXN49_RS02160	COG4549	nuclear export factor GLE1
LXN49_RS02165	COG1276	copper resistance
LXN49_RS02165	COG2372	response to copper ion
LXN49_RS02170	COG2213	PTS system mannitol-specific
LXN49_RS02175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS02180	COG0246	Mannitol dehydrogenase
LXN49_RS02185	COG0840	transmembrane signaling receptor activity
LXN49_RS02190	COG0300	oxidoreductase activity
LXN49_RS02195	COG0789	Transcriptional regulator
LXN49_RS02215	COG0346	lactoylglutathione lyase activity
LXN49_RS02225	COG0561	phosphatase activity
LXN49_RS02230	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LXN49_RS02235	COG1914	H( )-stimulated, divalent metal cation uptake system
LXN49_RS02240	COG4336	lyase activity
LXN49_RS02245	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LXN49_RS02250	COG1984	allophanate hydrolase subunit 2
LXN49_RS02255	COG1414	Transcriptional regulator
LXN49_RS02260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LXN49_RS02265	COG2755	lipolytic protein G-D-S-L family
LXN49_RS02275	COG3711	transcriptional antiterminator
LXN49_RS02280	COG2226	methyltransferase
LXN49_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS02290	COG3871	stress protein (general stress protein 26)
LXN49_RS02315	COG2814	Major facilitator Superfamily
LXN49_RS02325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LXN49_RS02325	COG0551	DNA topoisomerase type I activity
LXN49_RS02330	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LXN49_RS02335	COG3706	GGDEF domain
LXN49_RS02340	COG5298	Protein conserved in bacteria
LXN49_RS02345	COG1215	transferase activity, transferring glycosyl groups
LXN49_RS02355	COG0531	amino acid
LXN49_RS02360	COG0028	Belongs to the TPP enzyme family
LXN49_RS02365	COG5444	nuclease activity
LXN49_RS02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LXN49_RS02395	COG1914	H( )-stimulated, divalent metal cation uptake system
LXN49_RS02400	COG2261	transglycosylase associated protein
LXN49_RS02405	COG2217	Heavy metal translocating P-type atpase
LXN49_RS02410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LXN49_RS02415	COG3290	protein histidine kinase activity
LXN49_RS02420	COG4565	transcriptional regulatory protein
LXN49_RS02425	COG1301	dicarboxylic acid transport
LXN49_RS02430	COG0628	permease
LXN49_RS02435	COG1301	dicarboxylic acid transport
LXN49_RS02440	COG1131	(ABC) transporter
LXN49_RS02445	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LXN49_RS02460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXN49_RS02465	COG1181	Belongs to the D-alanine--D-alanine ligase family
LXN49_RS02470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LXN49_RS02485	COG0513	Belongs to the DEAD box helicase family
LXN49_RS02490	COG3402	PFAM membrane-flanked domain
LXN49_RS02495	COG3428	Bacterial PH domain
LXN49_RS02500	COG0705	Rhomboid family
LXN49_RS02505	COG0736	holo-[acyl-carrier-protein] synthase activity
LXN49_RS02510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LXN49_RS02515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LXN49_RS02520	COG0864	Transcriptional regulator
LXN49_RS02525	COG2337	Toxic component of a toxin-antitoxin (TA) module
LXN49_RS02530	COG1366	Belongs to the anti-sigma-factor antagonist family
LXN49_RS02535	COG1366	Belongs to the anti-sigma-factor antagonist family
LXN49_RS02540	COG2172	sigma factor antagonist activity
LXN49_RS02545	COG2208	phosphoserine phosphatase activity
LXN49_RS02550	COG1366	Belongs to the anti-sigma-factor antagonist family
LXN49_RS02555	COG2172	sigma factor antagonist activity
LXN49_RS02560	COG1191	sigma factor activity
LXN49_RS02565	COG2208	phosphoserine phosphatase activity
LXN49_RS02570	COG2183	response to ionizing radiation
LXN49_RS02580	COG3091	SprT-like family
LXN49_RS02585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LXN49_RS02590	COG0022	dehydrogenase e1 component
LXN49_RS02595	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXN49_RS02600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LXN49_RS02605	COG3284	Transcriptional regulator
LXN49_RS02660	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LXN49_RS02660	COG0456	acetyltransferase
LXN49_RS02665	COG1278	Cold shock
LXN49_RS02675	COG1064	alcohol dehydrogenase
LXN49_RS02680	COG0789	Transcriptional regulator
LXN49_RS02690	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LXN49_RS02715	COG0477	Major facilitator Superfamily
LXN49_RS02720	COG0657	acetylesterase activity
LXN49_RS02730	COG4221	oxidoreductase activity
LXN49_RS02740	COG0252	asparaginase activity
LXN49_RS02760	COG2814	Major facilitator Superfamily
LXN49_RS02765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LXN49_RS02795	COG1309	transcriptional regulator
LXN49_RS02800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LXN49_RS02805	COG1846	Transcriptional regulator
LXN49_RS02810	COG0778	Nitroreductase
LXN49_RS02825	COG1396	sequence-specific DNA binding
LXN49_RS02835	COG0456	acetyltransferase
LXN49_RS02845	COG4122	O-methyltransferase activity
LXN49_RS02855	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LXN49_RS02860	COG0697	spore germination
LXN49_RS02870	COG1301	dicarboxylic acid transport
LXN49_RS02910	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LXN49_RS02915	COG0802	atpase or kinase
LXN49_RS02920	COG1214	PFAM Peptidase M22, glycoprotease
LXN49_RS02925	COG0456	acetyltransferase
LXN49_RS02930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LXN49_RS02935	COG0488	(ABC) transporter
LXN49_RS02940	COG0315	cyclic pyranopterin monophosphate synthase activity
LXN49_RS02945	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LXN49_RS02950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LXN49_RS02955	COG0805	protein transport
LXN49_RS02970	COG1266	CAAX protease self-immunity
LXN49_RS02975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LXN49_RS02980	COG0459	protein refolding
LXN49_RS02985	COG1846	Transcriptional regulator
LXN49_RS02990	COG0456	acetyltransferase
LXN49_RS02995	COG2808	Putative FMN-binding domain
LXN49_RS03015	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LXN49_RS03020	COG0823	Involved in the tonB-independent uptake of proteins
LXN49_RS03030	COG2132	Multicopper oxidase
LXN49_RS03035	COG1113	amino acid transport
LXN49_RS03040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LXN49_RS03045	COG0714	Associated with various cellular activities
LXN49_RS03050	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
LXN49_RS03055	COG1305	Transglutaminase-like
LXN49_RS03060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LXN49_RS03060	COG0519	Catalyzes the synthesis of GMP from XMP
LXN49_RS03065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LXN49_RS03075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LXN49_RS03080	COG2207	Transcriptional regulator
LXN49_RS03100	COG1404	Belongs to the peptidase S8 family
LXN49_RS03120	COG1595	DNA-templated transcription, initiation
LXN49_RS03130	COG2814	Major facilitator Superfamily
LXN49_RS03135	COG0583	DNA-binding transcription factor activity
LXN49_RS03140	COG2252	PERMEase
LXN49_RS03155	COG3064	Membrane
LXN49_RS03160	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
LXN49_RS03170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LXN49_RS03175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LXN49_RS03180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LXN49_RS03185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LXN49_RS03190	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LXN49_RS03195	COG0047	phosphoribosylformylglycinamidine synthase activity
LXN49_RS03200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LXN49_RS03205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LXN49_RS03210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LXN49_RS03215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LXN49_RS03220	COG0138	bifunctional purine biosynthesis protein purh
LXN49_RS03225	COG0151	Belongs to the GarS family
LXN49_RS03245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LXN49_RS03250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LXN49_RS03255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LXN49_RS03260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LXN49_RS03270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LXN49_RS03275	COG4496	protein, YerC YecD
LXN49_RS03280	COG0069	glutamate synthase activity
LXN49_RS03300	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LXN49_RS03305	COG0210	DNA helicase
LXN49_RS03310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LXN49_RS03315	COG4851	CamS sex pheromone cAM373 precursor
LXN49_RS03330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXN49_RS03345	COG1250	3-hydroxyacyl-CoA dehydrogenase
LXN49_RS03360	COG1960	acyl-CoA dehydrogenase activity
LXN49_RS03390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LXN49_RS03395	COG1785	Belongs to the alkaline phosphatase family
LXN49_RS03400	COG1285	pathogenesis
LXN49_RS03405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LXN49_RS03410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LXN49_RS03415	COG0154	amidase activity
LXN49_RS03420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LXN49_RS03425	COG1309	transcriptional regulator
LXN49_RS03430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LXN49_RS03435	COG1957	nucleoside hydrolase
LXN49_RS03440	COG1597	lipid kinase activity
LXN49_RS03445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LXN49_RS03465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LXN49_RS03475	COG1737	Transcriptional regulator
LXN49_RS03480	COG1263	PTS System
LXN49_RS03480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS03485	COG1486	melibiose metabolic process
LXN49_RS03495	COG1959	2 iron, 2 sulfur cluster binding
LXN49_RS03500	COG0492	ferredoxin-NADP+ reductase activity
LXN49_RS03515	COG1486	melibiose metabolic process
LXN49_RS03525	COG2211	Major facilitator Superfamily
LXN49_RS03555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LXN49_RS03560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LXN49_RS03565	COG1442	glycosyl transferase family 8
LXN49_RS03570	COG1216	Glycosyl transferase, family 2
LXN49_RS03575	COG1442	glycosyl transferase family 8
LXN49_RS03580	COG2223	nitrite transmembrane transporter activity
LXN49_RS03590	COG0471	metal ion transport
LXN49_RS03605	COG0071	Belongs to the small heat shock protein (HSP20) family
LXN49_RS03620	COG0531	amino acid
LXN49_RS03625	COG0463	Glycosyl transferase, family 2
LXN49_RS03630	COG0488	(ABC) transporter
LXN49_RS03640	COG0210	DNA helicase
LXN49_RS03655	COG1469	GTP cyclohydrolase I activity
LXN49_RS03660	COG0789	Transcriptional regulator
LXN49_RS03665	COG2814	Major facilitator Superfamily
LXN49_RS03670	COG0488	(ABC) transporter
LXN49_RS03675	COG0513	Belongs to the DEAD box helicase family
LXN49_RS03680	COG2130	NADP-dependent
LXN49_RS03700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LXN49_RS03700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LXN49_RS03705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LXN49_RS03715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LXN49_RS03715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LXN49_RS03725	COG3290	protein histidine kinase activity
LXN49_RS03730	COG4565	transcriptional regulatory protein
LXN49_RS03735	COG3181	Tripartite tricarboxylate transporter family receptor
LXN49_RS03740	COG2851	Citrate transporter
LXN49_RS03750	COG3479	Phenolic acid decarboxylase
LXN49_RS03755	COG1695	Transcriptional regulator
LXN49_RS03760	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
LXN49_RS03765	COG0477	Major facilitator Superfamily
LXN49_RS03770	COG0583	DNA-binding transcription factor activity
LXN49_RS03775	COG1254	Belongs to the acylphosphatase family
LXN49_RS03780	COG2258	MOSC domain
LXN49_RS03795	COG0024	Methionine aminopeptidase
LXN49_RS03800	COG1263	PTS System
LXN49_RS03800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS03805	COG3739	integral membrane protein
LXN49_RS03825	COG1368	sulfuric ester hydrolase activity
LXN49_RS03830	COG0076	glutamate decarboxylase activity
LXN49_RS03835	COG0840	transmembrane signaling receptor activity
LXN49_RS03845	COG1263	PTS System
LXN49_RS03845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS03850	COG0366	Alpha amylase catalytic
LXN49_RS03855	COG2188	Transcriptional regulator
LXN49_RS03865	COG0737	Belongs to the 5'-nucleotidase family
LXN49_RS03870	COG0693	protein deglycase activity
LXN49_RS03875	COG4840	Belongs to the UPF0435 family
LXN49_RS03880	COG1115	amino acid carrier protein
LXN49_RS03885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LXN49_RS03890	COG4980	gas vesicle protein
LXN49_RS03895	COG1295	ribonuclease BN
LXN49_RS03900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LXN49_RS03905	COG0477	Major facilitator Superfamily
LXN49_RS03915	COG0387	Pfam Sodium calcium exchanger
LXN49_RS03925	COG0217	transcriptional regulatory protein
LXN49_RS03930	COG0668	transmembrane transport
LXN49_RS03935	COG0535	radical SAM domain protein
LXN49_RS03945	COG0726	polysaccharide deacetylase
LXN49_RS03955	COG0598	Magnesium transport protein CorA
LXN49_RS03965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LXN49_RS03970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LXN49_RS03985	COG0583	DNA-binding transcription factor activity
LXN49_RS03990	COG1942	4-Oxalocrotonate Tautomerase
LXN49_RS03995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LXN49_RS04000	COG0789	Transcriptional regulator
LXN49_RS04005	COG2814	Major facilitator Superfamily
LXN49_RS04015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LXN49_RS04060	COG2076	Multidrug Resistance protein
LXN49_RS04065	COG2076	Multidrug Resistance protein
LXN49_RS04070	COG1309	transcriptional regulator
LXN49_RS04080	COG4637	Psort location Cytoplasmic, score
LXN49_RS04085	COG2755	lipolytic protein G-D-S-L family
LXN49_RS04090	COG0492	ferredoxin-NADP+ reductase activity
LXN49_RS04095	COG1742	UPF0060 membrane protein
LXN49_RS04100	COG1595	DNA-templated transcription, initiation
LXN49_RS04120	COG2318	DinB family
LXN49_RS04130	COG1846	Transcriptional regulator
LXN49_RS04135	COG0392	lysyltransferase activity
LXN49_RS04135	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LXN49_RS04155	COG0778	Nitroreductase
LXN49_RS04170	COG1090	epimerase
LXN49_RS04175	COG2137	regulation of response to DNA damage stimulus
LXN49_RS04200	COG0463	Glycosyl transferase, family 2
LXN49_RS04205	COG4485	Bacterial membrane protein, YfhO
LXN49_RS04215	COG2140	Oxalate decarboxylase
LXN49_RS04225	COG1191	sigma factor activity
LXN49_RS04270	COG1988	membrane-bound metal-dependent
LXN49_RS04275	COG1194	a g-specific adenine glycosylase
LXN49_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS04300	COG3557	Belongs to the UPF0374 family
LXN49_RS04305	COG1132	(ABC) transporter
LXN49_RS04310	COG0444	Belongs to the ABC transporter superfamily
LXN49_RS04315	COG4608	Belongs to the ABC transporter superfamily
LXN49_RS04320	COG0747	negative chemotaxis
LXN49_RS04325	COG0601	transmembrane transport
LXN49_RS04330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXN49_RS04335	COG4129	membrane
LXN49_RS04340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LXN49_RS04345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LXN49_RS04350	COG0735	belongs to the Fur family
LXN49_RS04500	COG1368	sulfuric ester hydrolase activity
LXN49_RS04505	COG0681	Belongs to the peptidase S26 family
LXN49_RS04510	COG2873	o-acetylhomoserine
LXN49_RS04520	COG1116	anion transmembrane transporter activity
LXN49_RS04525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LXN49_RS04530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LXN49_RS04545	COG4152	abc transporter atp-binding protein
LXN49_RS04575	COG3382	B3 4 domain protein
LXN49_RS04580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LXN49_RS04590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LXN49_RS04595	COG2766	serine protein kinase
LXN49_RS04600	COG2718	Belongs to the UPF0229 family
LXN49_RS04605	COG1566	PFAM secretion protein HlyD family protein
LXN49_RS04610	COG2814	Major facilitator Superfamily
LXN49_RS04615	COG0655	NAD(P)H dehydrogenase (quinone) activity
LXN49_RS04625	COG1278	Cold shock
LXN49_RS04630	COG3706	GGDEF domain
LXN49_RS04655	COG5577	PFAM Coat F domain
LXN49_RS04660	COG5002	protein histidine kinase activity
LXN49_RS04665	COG0737	Belongs to the 5'-nucleotidase family
LXN49_RS04665	COG1525	nuclease
LXN49_RS04665	COG4085	toxin activity
LXN49_RS04670	COG3764	Sortase (surface protein transpeptidase)
LXN49_RS04675	COG0564	pseudouridine synthase activity
LXN49_RS04685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LXN49_RS04690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LXN49_RS04690	COG3153	acetyltransferase
LXN49_RS04705	COG3835	regulator
LXN49_RS04710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LXN49_RS04715	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LXN49_RS04720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LXN49_RS04725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LXN49_RS04730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LXN49_RS04735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LXN49_RS04740	COG2203	Gaf domain
LXN49_RS04740	COG4585	Histidine kinase
LXN49_RS04745	COG2197	response regulator
LXN49_RS04760	COG0753	catalase activity
LXN49_RS04765	COG1959	2 iron, 2 sulfur cluster binding
LXN49_RS04770	COG1017	nitric oxide dioxygenase activity
LXN49_RS04770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LXN49_RS04775	COG2719	SpoVR family
LXN49_RS04780	COG1785	Belongs to the alkaline phosphatase family
LXN49_RS04785	COG0791	NLP P60 protein
LXN49_RS04785	COG1388	LysM domain
LXN49_RS04790	COG0531	amino acid
LXN49_RS04805	COG1595	DNA-templated transcription, initiation
LXN49_RS04810	COG0204	Acyl-transferase
LXN49_RS04815	COG1253	flavin adenine dinucleotide binding
LXN49_RS04820	COG0789	Transcriptional regulator
LXN49_RS04825	COG1253	flavin adenine dinucleotide binding
LXN49_RS04835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LXN49_RS04840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LXN49_RS04845	COG0584	glycerophosphoryl diester phosphodiesterase
LXN49_RS04855	COG0668	transmembrane transport
LXN49_RS04860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LXN49_RS04865	COG0726	polysaccharide deacetylase
LXN49_RS04870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LXN49_RS04875	COG0589	response to stress
LXN49_RS04880	COG1132	(ABC) transporter
LXN49_RS04885	COG1132	(ABC) transporter
LXN49_RS04890	COG0702	epimerase
LXN49_RS04900	COG3842	ATPase activity
LXN49_RS04905	COG2508	Transcriptional regulator
LXN49_RS04915	COG0189	ligase activity
LXN49_RS04920	COG0189	ligase activity
LXN49_RS04925	COG4399	Belongs to the UPF0754 family
LXN49_RS04930	COG3679	Belongs to the UPF0342 family
LXN49_RS04935	COG0561	phosphatase activity
LXN49_RS04940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LXN49_RS04950	COG0475	glutathione-regulated potassium exporter activity
LXN49_RS04955	COG0490	domain, Protein
LXN49_RS04965	COG1024	Enoyl-CoA hydratase
LXN49_RS04975	COG0420	3'-5' exonuclease activity
LXN49_RS04980	COG4717	serine-type aminopeptidase activity
LXN49_RS04985	COG3481	metal-dependent phosphohydrolase, HD sub domain
LXN49_RS04995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LXN49_RS05025	COG1846	Transcriptional regulator
LXN49_RS05030	COG4980	gas vesicle protein
LXN49_RS05045	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LXN49_RS05050	COG0537	adenosine 5'-monophosphoramidase activity
LXN49_RS05055	COG1131	(ABC) transporter
LXN49_RS05060	COG4473	ABC transporter
LXN49_RS05070	COG1473	amidohydrolase
LXN49_RS05080	COG2329	Antibiotic biosynthesis monooxygenase
LXN49_RS05085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LXN49_RS05090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LXN49_RS05095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LXN49_RS05100	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LXN49_RS05105	COG1309	transcriptional regulator
LXN49_RS05110	COG1511	domain protein
LXN49_RS05115	COG1363	Peptidase, m42
LXN49_RS05120	COG1301	dicarboxylic acid transport
LXN49_RS05130	COG1234	tRNA 3'-trailer cleavage
LXN49_RS05135	COG0095	Lipoate-protein ligase
LXN49_RS05140	COG0318	PFAM AMP-dependent synthetase and ligase
LXN49_RS05150	COG0501	Belongs to the peptidase M48B family
LXN49_RS05155	COG1404	Belongs to the peptidase S8 family
LXN49_RS05160	COG0406	alpha-ribazole phosphatase activity
LXN49_RS05165	COG0840	transmembrane signaling receptor activity
LXN49_RS05170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LXN49_RS05170	COG0723	plastoquinol--plastocyanin reductase activity
LXN49_RS05175	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS05185	COG4903	ComK protein
LXN49_RS05195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXN49_RS05200	COG2814	Major facilitator Superfamily
LXN49_RS05205	COG2732	(Barnase) inhibitor
LXN49_RS05210	COG1316	TRANSCRIPTIONal
LXN49_RS05220	COG0398	Pfam SNARE associated Golgi protein
LXN49_RS05225	COG0681	Belongs to the peptidase S26 family
LXN49_RS05230	COG3180	Ammonia monooxygenase
LXN49_RS05240	COG0501	Belongs to the peptidase M48B family
LXN49_RS05245	COG2259	Doxx family
LXN49_RS05250	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LXN49_RS05255	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LXN49_RS05260	COG1074	ATP-dependent DNA helicase activity
LXN49_RS05265	COG0420	3'-5' exonuclease activity
LXN49_RS05270	COG0419	ATPase involved in DNA repair
LXN49_RS05275	COG1403	HNH endonuclease
LXN49_RS05315	COG5337	Spore coat protein CotH
LXN49_RS05325	COG0179	Fumarylacetoacetate (FAA) hydrolase
LXN49_RS05340	COG0367	asparagine synthase
LXN49_RS05355	COG1562	ergosterol biosynthetic process
LXN49_RS05360	COG0534	Mate efflux family protein
LXN49_RS05365	COG1917	Cupin 2, conserved barrel domain protein
LXN49_RS05365	COG2207	Transcriptional regulator
LXN49_RS05390	COG0076	glutamate decarboxylase activity
LXN49_RS05420	COG0646	methionine synthase
LXN49_RS05420	COG1410	methionine synthase
LXN49_RS05425	COG0646	methionine synthase
LXN49_RS05425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LXN49_RS05435	COG2996	Protein conserved in bacteria
LXN49_RS05440	COG1744	ABC transporter substrate-binding protein PnrA-like
LXN49_RS05445	COG0840	transmembrane signaling receptor activity
LXN49_RS05450	COG1307	EDD domain protein, DegV family
LXN49_RS05455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LXN49_RS05475	COG0561	phosphatase activity
LXN49_RS05480	COG1073	alpha beta
LXN49_RS05485	COG2151	metal-sulfur cluster biosynthetic enzyme
LXN49_RS05490	COG0277	FAD linked oxidase domain protein
LXN49_RS05495	COG2271	Major facilitator Superfamily
LXN49_RS05500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LXN49_RS05505	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LXN49_RS05510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LXN49_RS05515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LXN49_RS05520	COG0505	Belongs to the CarA family
LXN49_RS05525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LXN49_RS05530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LXN49_RS05540	COG2814	Major facilitator Superfamily
LXN49_RS05550	COG2267	carboxylic ester hydrolase activity
LXN49_RS05560	COG1744	ABC transporter substrate-binding protein PnrA-like
LXN49_RS05575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LXN49_RS05580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LXN49_RS05585	COG5504	Zn-dependent protease
LXN49_RS05590	COG0444	Belongs to the ABC transporter superfamily
LXN49_RS05595	COG4608	Belongs to the ABC transporter superfamily
LXN49_RS05605	COG0601	transmembrane transport
LXN49_RS05610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXN49_RS05620	COG0180	Tryptophanyl-tRNA synthetase
LXN49_RS05625	COG4166	transmembrane transport
LXN49_RS05630	COG0601	transmembrane transport
LXN49_RS05635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXN49_RS05640	COG0444	Belongs to the ABC transporter superfamily
LXN49_RS05645	COG4608	Belongs to the ABC transporter superfamily
LXN49_RS05655	COG0456	acetyltransferase
LXN49_RS05660	COG1393	Belongs to the ArsC family
LXN49_RS05665	COG0861	Integral membrane protein TerC family
LXN49_RS05670	COG4862	establishment of competence for transformation
LXN49_RS05675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LXN49_RS05685	COG1164	Oligoendopeptidase f
LXN49_RS05695	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LXN49_RS05700	COG2346	COG2346, Truncated hemoglobins
LXN49_RS05705	COG0741	lytic transglycosylase activity
LXN49_RS05710	COG4116	CYTH
LXN49_RS05720	COG2357	RelA SpoT domain protein
LXN49_RS05725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LXN49_RS05730	COG0564	pseudouridine synthase activity
LXN49_RS05735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LXN49_RS05740	COG0475	glutathione-regulated potassium exporter activity
LXN49_RS05740	COG0569	domain protein
LXN49_RS05745	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LXN49_RS05750	COG0352	thiamine-phosphate diphosphorylase activity
LXN49_RS05760	COG2104	thiamine diphosphate biosynthetic process
LXN49_RS05765	COG2022	thiamine diphosphate biosynthetic process
LXN49_RS05770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LXN49_RS05775	COG0351	phosphomethylpyrimidine kinase
LXN49_RS05780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LXN49_RS05835	COG0210	DNA helicase
LXN49_RS05850	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LXN49_RS05855	COG2382	esterase
LXN49_RS05860	COG0626	cystathionine gamma-synthase activity
LXN49_RS05865	COG0626	cystathionine gamma-synthase activity
LXN49_RS05880	COG0457	Tetratricopeptide repeat
LXN49_RS05885	COG1733	regulation of RNA biosynthetic process
LXN49_RS05900	COG0825	malonyl-CoA metabolic process
LXN49_RS05910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LXN49_RS05935	COG0457	Tetratricopeptide repeat
LXN49_RS05955	COG3173	Aminoglycoside phosphotransferase
LXN49_RS05960	COG0583	DNA-binding transcription factor activity
LXN49_RS05985	COG2807	transmembrane transport
LXN49_RS06015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LXN49_RS06035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LXN49_RS06040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LXN49_RS06060	COG4195	phage-related replication protein
LXN49_RS06065	COG2856	Zn peptidase
LXN49_RS06070	COG3409	Peptidoglycan-binding domain 1 protein
LXN49_RS06070	COG5632	N-Acetylmuramoyl-L-alanine amidase
LXN49_RS06090	COG0306	phosphate transporter
LXN49_RS06095	COG1392	Phosphate transport regulator
LXN49_RS06105	COG0405	Gamma-glutamyltransferase
LXN49_RS06110	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LXN49_RS06120	COG4208	sulfate ABC transporter
LXN49_RS06125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LXN49_RS06135	COG3775	system Galactitol-specific IIC component
LXN49_RS06150	COG1063	alcohol dehydrogenase
LXN49_RS06155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LXN49_RS06160	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXN49_RS06160	COG0022	dehydrogenase e1 component
LXN49_RS06165	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXN49_RS06170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LXN49_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS06180	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS06185	COG2390	Transcriptional regulator
LXN49_RS06195	COG0531	amino acid
LXN49_RS06200	COG0346	lactoylglutathione lyase activity
LXN49_RS06205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LXN49_RS06210	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LXN49_RS06215	COG2362	D-Aminopeptidase
LXN49_RS06220	COG0601	transmembrane transport
LXN49_RS06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXN49_RS06230	COG0444	Belongs to the ABC transporter superfamily
LXN49_RS06235	COG4166	transmembrane transport
LXN49_RS06240	COG1619	proteins homologs of microcin C7 resistance protein MccF
LXN49_RS06245	COG4948	Mandelate Racemase Muconate Lactonizing
LXN49_RS06250	COG0791	NLP P60 protein
LXN49_RS06255	COG4608	Belongs to the ABC transporter superfamily
LXN49_RS06260	COG1834	amidinotransferase
LXN49_RS06265	COG1607	acyl-coa hydrolase
LXN49_RS06270	COG1695	Transcriptional regulator
LXN49_RS06285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LXN49_RS06300	COG2076	Multidrug Resistance protein
LXN49_RS06305	COG2076	Multidrug Resistance protein
LXN49_RS06315	COG0788	formyltetrahydrofolate deformylase activity
LXN49_RS06320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LXN49_RS06325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LXN49_RS06330	COG0457	Tetratricopeptide repeat
LXN49_RS06340	COG1764	response to oxidative stress
LXN49_RS06345	COG1846	Transcriptional regulator
LXN49_RS06350	COG1764	response to oxidative stress
LXN49_RS06355	COG0590	tRNA wobble adenosine to inosine editing
LXN49_RS06360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LXN49_RS06365	COG1404	Belongs to the peptidase S8 family
LXN49_RS06370	COG0745	RESPONSE REGULATOR receiver
LXN49_RS06375	COG5002	protein histidine kinase activity
LXN49_RS06375	COG3850	Histidine kinase
LXN49_RS06380	COG3212	peptidase
LXN49_RS06385	COG3212	peptidase
LXN49_RS06395	COG2239	Acts as a magnesium transporter
LXN49_RS06405	COG0789	Transcriptional regulator
LXN49_RS06420	COG1846	Transcriptional regulator
LXN49_RS06425	COG5001	Diguanylate cyclase
LXN49_RS06425	COG3300	MHYT domain
LXN49_RS06430	COG0586	Pfam SNARE associated Golgi protein
LXN49_RS06440	COG1191	sigma factor activity
LXN49_RS06460	COG0501	Belongs to the peptidase M48B family
LXN49_RS06465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LXN49_RS06470	COG2323	membrane
LXN49_RS06485	COG3594	Acyltransferase
LXN49_RS06490	COG5002	protein histidine kinase activity
LXN49_RS06495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LXN49_RS06505	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LXN49_RS06510	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LXN49_RS06515	COG0436	Aminotransferase
LXN49_RS06520	COG1850	ribulose-bisphosphate carboxylase activity
LXN49_RS06525	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
LXN49_RS06530	COG0235	Class ii aldolase
LXN49_RS06535	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LXN49_RS06545	COG3852	Histidine kinase
LXN49_RS06550	COG1846	Transcriptional regulator
LXN49_RS06555	COG1360	Flagellar Motor Protein
LXN49_RS06560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LXN49_RS06565	COG0542	response to heat
LXN49_RS06570	COG3949	Membrane
LXN49_RS06575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LXN49_RS06580	COG0720	synthase
LXN49_RS06585	COG0602	queuosine metabolic process
LXN49_RS06590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LXN49_RS06595	COG1733	regulation of RNA biosynthetic process
LXN49_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS06610	COG4873	Protein conserved in bacteria
LXN49_RS06620	COG3773	Cell wall hydrolase
LXN49_RS06625	COG2244	polysaccharide biosynthetic process
LXN49_RS06630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXN49_RS06635	COG2217	Heavy metal translocating P-type atpase
LXN49_RS06640	COG0006	proline dipeptidase activity
LXN49_RS06650	COG1609	Transcriptional regulator
LXN49_RS06655	COG3711	transcriptional antiterminator
LXN49_RS06660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS06660	COG2190	(PTS) system
LXN49_RS06660	COG1263	PTS System
LXN49_RS06665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS06670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LXN49_RS06680	COG1533	DNA photolyase activity
LXN49_RS06685	COG0840	transmembrane signaling receptor activity
LXN49_RS06695	COG2084	Dehydrogenase
LXN49_RS06700	COG2340	Cysteine-rich secretory protein family
LXN49_RS06705	COG0768	penicillin binding
LXN49_RS06710	COG4191	Histidine kinase
LXN49_RS06715	COG0436	Aminotransferase
LXN49_RS06720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LXN49_RS06730	COG1714	RDD family
LXN49_RS06740	COG0835	chemotaxis
LXN49_RS06740	COG0784	Response regulator, receiver
LXN49_RS06760	COG1917	Cupin 2, conserved barrel domain protein
LXN49_RS06760	COG2207	Transcriptional regulator
LXN49_RS06765	COG0697	spore germination
LXN49_RS06775	COG2814	Major facilitator Superfamily
LXN49_RS06780	COG1376	ErfK ybiS ycfS ynhG family protein
LXN49_RS06785	COG1408	metallophosphoesterase
LXN49_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS06795	COG2200	EAL domain
LXN49_RS06800	COG3546	catalase activity
LXN49_RS06805	COG4703	Protein of unknown function (DUF1797)
LXN49_RS06810	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
LXN49_RS06820	COG0517	IMP dehydrogenase activity
LXN49_RS06825	COG0583	DNA-binding transcription factor activity
LXN49_RS06835	COG0716	FMN binding
LXN49_RS06845	COG0716	FMN binding
LXN49_RS06850	COG2171	N-acyltransferase activity
LXN49_RS06855	COG1473	amidohydrolase
LXN49_RS06865	COG0668	transmembrane transport
LXN49_RS06870	COG0450	alkyl hydroperoxide reductase
LXN49_RS06875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXN49_RS06890	COG0746	molybdenum cofactor guanylyltransferase activity
LXN49_RS06895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LXN49_RS06900	COG0303	'Molybdopterin
LXN49_RS06905	COG1763	Mo-molybdopterin cofactor biosynthetic process
LXN49_RS06910	COG0314	molybdopterin synthase activity
LXN49_RS06915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LXN49_RS06930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LXN49_RS06935	COG1136	(ABC) transporter
LXN49_RS06940	COG0577	efflux transmembrane transporter activity
LXN49_RS06945	COG1349	DNA-binding transcription factor activity
LXN49_RS06950	COG1105	Belongs to the carbohydrate kinase PfkB family
LXN49_RS06955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXN49_RS06955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXN49_RS06955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS06970	COG0488	(ABC) transporter
LXN49_RS06975	COG2309	aminopeptidase activity
LXN49_RS06985	COG1077	Cell shape determining protein MreB Mrl
LXN49_RS06990	COG2002	toxin-antitoxin pair type II binding
LXN49_RS06995	COG3852	Histidine kinase
LXN49_RS07000	COG2105	PFAM AIG2 family protein
LXN49_RS07000	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
LXN49_RS07005	COG0569	domain protein
LXN49_RS07010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LXN49_RS07015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LXN49_RS07020	COG5503	Protein of unknown function (DUF1447)
LXN49_RS07025	COG0561	phosphatase activity
LXN49_RS07030	COG0242	peptide deformylase activity
LXN49_RS07045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LXN49_RS07050	COG0022	dehydrogenase e1 component
LXN49_RS07055	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXN49_RS07060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LXN49_RS07065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXN49_RS07075	COG1982	Orn Lys Arg decarboxylase major
LXN49_RS07080	COG4476	Belongs to the UPF0223 family
LXN49_RS07085	COG4493	Belongs to the UPF0637 family
LXN49_RS07095	COG0483	inositol monophosphate 1-phosphatase activity
LXN49_RS07110	COG1595	DNA-templated transcription, initiation
LXN49_RS07130	COG1217	gtp-binding protein TYPA
LXN49_RS07140	COG4896	Protein conserved in bacteria
LXN49_RS07150	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LXN49_RS07155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LXN49_RS07160	COG2066	Belongs to the glutaminase family
LXN49_RS07165	COG4838	Belongs to the UPF0358 family
LXN49_RS07170	COG0772	Belongs to the SEDS family
LXN49_RS07175	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LXN49_RS07180	COG0415	Belongs to the DNA photolyase family
LXN49_RS07185	COG1612	heme a metabolic process
LXN49_RS07190	COG0109	protoheme IX farnesyltransferase activity
LXN49_RS07195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LXN49_RS07195	COG2010	Cytochrome c
LXN49_RS07200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LXN49_RS07205	COG1845	cytochrome c oxidase, subunit III
LXN49_RS07210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LXN49_RS07215	COG3336	cytochrome c oxidase
LXN49_RS07225	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LXN49_RS07230	COG2340	Cysteine-rich secretory protein family
LXN49_RS07250	COG3679	Belongs to the UPF0342 family
LXN49_RS07255	COG4471	UPF0298 protein
LXN49_RS07260	COG0742	ribosomal rna small subunit methyltransferase
LXN49_RS07265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LXN49_RS07270	COG3314	Sporulation integral membrane protein YlbJ
LXN49_RS07275	COG1752	Esterase of the alpha-beta hydrolase superfamily
LXN49_RS07280	COG3480	Lon protease (S16) C-terminal proteolytic domain
LXN49_RS07290	COG1399	metal-binding, possibly nucleic acid-binding protein
LXN49_RS07295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LXN49_RS07305	COG0454	-acetyltransferase
LXN49_RS07310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LXN49_RS07315	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LXN49_RS07320	COG2001	Belongs to the MraZ family
LXN49_RS07325	COG0275	rRNA processing
LXN49_RS07330	COG4839	cell division protein FtsL
LXN49_RS07335	COG0768	penicillin binding
LXN49_RS07340	COG0768	penicillin binding
LXN49_RS07345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LXN49_RS07350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LXN49_RS07355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LXN49_RS07360	COG0772	Belongs to the SEDS family
LXN49_RS07365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LXN49_RS07370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LXN49_RS07375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LXN49_RS07380	COG3879	Bacterial protein of unknown function (DUF881)
LXN49_RS07385	COG3879	Bacterial protein of unknown function (DUF881)
LXN49_RS07390	COG3856	small basic protein
LXN49_RS07395	COG0849	cell division
LXN49_RS07400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LXN49_RS07405	COG4412	M6 family metalloprotease domain protein
LXN49_RS07405	COG1404	Belongs to the peptidase S8 family
LXN49_RS07415	COG1191	sigma factor activity
LXN49_RS07420	COG1191	sigma factor activity
LXN49_RS07425	COG2390	Transcriptional regulator
LXN49_RS07440	COG3730	PTS system glucitol sorbitol-specific
LXN49_RS07445	COG3732	PTS system glucitol sorbitol-specific
LXN49_RS07455	COG1119	ATPase activity
LXN49_RS07460	COG1873	PFAM PRC-barrel domain
LXN49_RS07465	COG1496	oxidoreductase activity
LXN49_RS07470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LXN49_RS07475	COG1799	cell septum assembly
LXN49_RS07480	COG0762	integral membrane protein
LXN49_RS07485	COG2302	S4 RNA-binding domain
LXN49_RS07490	COG3599	regulation of cell shape
LXN49_RS07495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LXN49_RS07500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LXN49_RS07505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LXN49_RS07510	COG0564	pseudouridine synthase activity
LXN49_RS07515	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LXN49_RS07520	COG2233	PERMEase
LXN49_RS07525	COG0540	Belongs to the ATCase OTCase family
LXN49_RS07530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LXN49_RS07535	COG0505	Belongs to the CarA family
LXN49_RS07540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LXN49_RS07545	COG0543	2 iron, 2 sulfur cluster binding
LXN49_RS07550	COG0167	dihydroorotate dehydrogenase activity
LXN49_RS07555	COG0284	orotidine-5'-phosphate decarboxylase activity
LXN49_RS07560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LXN49_RS07570	COG0175	sulfate reduction
LXN49_RS07575	COG0306	phosphate transporter
LXN49_RS07580	COG2046	Belongs to the sulfate adenylyltransferase family
LXN49_RS07585	COG0529	Catalyzes the synthesis of activated sulfate
LXN49_RS07590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LXN49_RS07595	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
LXN49_RS07600	COG1648	precorrin-2 dehydrogenase activity
LXN49_RS07610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LXN49_RS07615	COG1561	YicC-like family, N-terminal region
LXN49_RS07620	COG2052	Domain of unknown function (DUF370)
LXN49_RS07625	COG0194	GDP metabolic process
LXN49_RS07630	COG1758	RNA polymerase activity
LXN49_RS07635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LXN49_RS07640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LXN49_RS07645	COG0242	peptide deformylase activity
LXN49_RS07650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LXN49_RS07655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LXN49_RS07655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LXN49_RS07660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LXN49_RS07665	COG0631	protein serine/threonine phosphatase activity
LXN49_RS07670	COG0515	serine threonine protein kinase
LXN49_RS07670	COG2815	serine threonine protein kinase
LXN49_RS07675	COG1162	GTPase activity
LXN49_RS07680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LXN49_RS07685	COG1564	THIamine pyrophosphokinase
LXN49_RS07695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LXN49_RS07700	COG1302	Protein conserved in bacteria
LXN49_RS07705	COG1461	Dihydroxyacetone kinase
LXN49_RS07710	COG1760	l-serine dehydratase
LXN49_RS07715	COG1760	l-serine dehydratase
LXN49_RS07720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LXN49_RS07725	COG1349	DNA-binding transcription factor activity
LXN49_RS07730	COG0416	fatty acid biosynthetic process
LXN49_RS07735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LXN49_RS07740	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS07745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LXN49_RS07755	COG1196	nuclear chromosome segregation
LXN49_RS07760	COG0552	protein localization to endoplasmic reticulum
LXN49_RS07765	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LXN49_RS07770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LXN49_RS07775	COG0228	four-way junction DNA binding
LXN49_RS07780	COG1837	Belongs to the UPF0109 family
LXN49_RS07790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LXN49_RS07795	COG0336	Belongs to the RNA methyltransferase TrmD family
LXN49_RS07800	COG0335	large ribosomal subunit rRNA binding
LXN49_RS07805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LXN49_RS07810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LXN49_RS07820	COG2257	FlhB HrpN YscU SpaS Family
LXN49_RS07825	COG0045	succinate-CoA ligase (ADP-forming) activity
LXN49_RS07830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LXN49_RS07835	COG0758	DNA mediated transformation
LXN49_RS07840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LXN49_RS07845	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LXN49_RS07850	COG4974	Belongs to the 'phage' integrase family
LXN49_RS07855	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LXN49_RS07860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LXN49_RS07865	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LXN49_RS07870	COG1815	bacterial-type flagellum-dependent cell motility
LXN49_RS07875	COG1558	bacterial-type flagellum-dependent cell motility
LXN49_RS07880	COG1677	Flagellar hook-basal body complex protein FliE
LXN49_RS07885	COG1766	The M ring may be actively involved in energy transduction
LXN49_RS07890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LXN49_RS07895	COG1317	bacterial-type flagellum organization
LXN49_RS07900	COG1157	protein secretion by the type III secretion system
LXN49_RS07905	COG2882	bacterial-type flagellum organization
LXN49_RS07910	COG3334	PFAM MgtE intracellular
LXN49_RS07915	COG3144	bacterial-type flagellum assembly
LXN49_RS07920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LXN49_RS07925	COG4786	Flagellar basal body rod
LXN49_RS07930	COG1582	Flagellar protein (FlbD)
LXN49_RS07935	COG1580	Controls the rotational direction of flagella during chemotaxis
LXN49_RS07940	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LXN49_RS07945	COG1776	CheC inhibitor of MCP methylation
LXN49_RS07945	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LXN49_RS07950	COG2201	protein-glutamate methylesterase activity
LXN49_RS07955	COG3190	flagellar
LXN49_RS07960	COG1338	Plays a role in the flagellum-specific transport system
LXN49_RS07965	COG1987	bacterial-type flagellum assembly
LXN49_RS07970	COG1684	flagellar biosynthetic protein fliR
LXN49_RS07975	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LXN49_RS07980	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LXN49_RS07985	COG1419	protein localization to endoplasmic reticulum
LXN49_RS07990	COG0455	bacterial-type flagellum organization
LXN49_RS07995	COG2201	protein-glutamate methylesterase activity
LXN49_RS08000	COG0643	Histidine kinase
LXN49_RS08000	COG2198	Histidine kinase
LXN49_RS08005	COG0835	chemotaxis
LXN49_RS08010	COG1776	CheC inhibitor of MCP methylation
LXN49_RS08015	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LXN49_RS08020	COG1191	sigma factor activity
LXN49_RS08035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LXN49_RS08040	COG0528	UMP kinase activity
LXN49_RS08045	COG0233	cytoplasmic translational termination
LXN49_RS08050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LXN49_RS08055	COG4589	Belongs to the CDS family
LXN49_RS08060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LXN49_RS08065	COG0750	zinc metalloprotease
LXN49_RS08070	COG0442	prolyl-tRNA aminoacylation
LXN49_RS08075	COG2176	DNA-directed DNA polymerase activity
LXN49_RS08090	COG3693	PFAM glycoside hydrolase, family 10
LXN49_RS08110	COG1131	(ABC) transporter
LXN49_RS08155	COG2890	protein-(glutamine-N5) methyltransferase activity
LXN49_RS08160	COG0779	Required for maturation of 30S ribosomal subunits
LXN49_RS08165	COG0195	Participates in both transcription termination and antitermination
LXN49_RS08170	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LXN49_RS08175	COG1358	cellular component organization or biogenesis
LXN49_RS08180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LXN49_RS08185	COG1550	Protein conserved in bacteria
LXN49_RS08190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LXN49_RS08195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LXN49_RS08200	COG0196	riboflavin kinase activity
LXN49_RS08205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LXN49_RS08210	COG1185	polyribonucleotide nucleotidyltransferase activity
LXN49_RS08215	COG0726	polysaccharide deacetylase
LXN49_RS08220	COG0612	Peptidase, M16
LXN49_RS08230	COG1873	PFAM PRC-barrel domain
LXN49_RS08235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LXN49_RS08240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LXN49_RS08245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LXN49_RS08250	COG0527	aspartate kinase activity
LXN49_RS08260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LXN49_RS08265	COG0740	serine-type endopeptidase activity
LXN49_RS08275	COG4980	gas vesicle protein
LXN49_RS08275	COG1674	ftsk spoiiie
LXN49_RS08280	COG2188	Transcriptional regulator
LXN49_RS08285	COG2814	Major facilitator Superfamily
LXN49_RS08290	COG2409	Drug exporters of the RND superfamily
LXN49_RS08290	COG1033	growth of symbiont in host cell
LXN49_RS08295	COG0612	Peptidase, M16
LXN49_RS08300	COG0612	Peptidase, M16
LXN49_RS08310	COG1033	growth of symbiont in host cell
LXN49_RS08310	COG2409	Drug exporters of the RND superfamily
LXN49_RS08315	COG0300	oxidoreductase activity
LXN49_RS08330	COG1426	Protein conserved in bacteria
LXN49_RS08335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LXN49_RS08340	COG1546	Belongs to the CinA family
LXN49_RS08340	COG1058	Belongs to the CinA family
LXN49_RS08345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LXN49_RS08350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LXN49_RS08355	COG1418	mRNA catabolic process
LXN49_RS08360	COG1692	metallophosphoesterase
LXN49_RS08365	COG2359	stage V sporulation protein S
LXN49_RS08370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LXN49_RS08375	COG1063	alcohol dehydrogenase
LXN49_RS08380	COG0156	8-amino-7-oxononanoate synthase activity
LXN49_RS08390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LXN49_RS08395	COG4550	Control of competence regulator ComK, YlbF/YmcA
LXN49_RS08405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LXN49_RS08410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LXN49_RS08425	COG1329	Transcriptional regulator
LXN49_RS08430	COG4195	phage-related replication protein
LXN49_RS08435	COG0457	Tetratricopeptide repeat
LXN49_RS08440	COG1404	Belongs to the peptidase S8 family
LXN49_RS08445	COG4195	phage-related replication protein
LXN49_RS08450	COG1764	response to oxidative stress
LXN49_RS08455	COG2076	Multidrug Resistance protein
LXN49_RS08480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LXN49_RS08485	COG1923	regulation of RNA biosynthetic process
LXN49_RS08500	COG1780	Probably involved in ribonucleotide reductase function
LXN49_RS08505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LXN49_RS08510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LXN49_RS08515	COG4112	unkown
LXN49_RS08520	COG0860	N-Acetylmuramoyl-L-alanine amidase
LXN49_RS08525	COG0464	growth
LXN49_RS08530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LXN49_RS08535	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LXN49_RS08540	COG0789	Transcriptional regulator
LXN49_RS08545	COG0174	glutamine synthetase
LXN49_RS08570	COG1404	Belongs to the peptidase S8 family
LXN49_RS08600	COG2369	cell adhesion
LXN49_RS08625	COG0457	Tetratricopeptide repeat
LXN49_RS08630	COG5444	nuclease activity
LXN49_RS08660	COG5646	InterPro IPR014922
LXN49_RS08665	COG0457	Tetratricopeptide repeat
LXN49_RS08670	COG3619	membrane
LXN49_RS08675	COG1793	dna ligase
LXN49_RS08675	COG3285	dna ligase
LXN49_RS08680	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LXN49_RS08685	COG4876	unkown
LXN49_RS08690	COG0346	lactoylglutathione lyase activity
LXN49_RS08695	COG1959	2 iron, 2 sulfur cluster binding
LXN49_RS08700	COG0702	epimerase
LXN49_RS08720	COG2323	membrane
LXN49_RS08725	COG1309	transcriptional regulator
LXN49_RS08730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LXN49_RS08730	COG2124	cytochrome p450
LXN49_RS08735	COG3591	Belongs to the peptidase S1B family
LXN49_RS08740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LXN49_RS08745	COG3209	COG3209 Rhs family protein
LXN49_RS08750	COG1366	Belongs to the anti-sigma-factor antagonist family
LXN49_RS08765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LXN49_RS08770	COG1388	LysM domain
LXN49_RS08775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LXN49_RS08780	COG4224	UPF0291 protein
LXN49_RS08785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LXN49_RS08795	COG3763	UPF0154 protein
LXN49_RS08805	COG0785	Cytochrome C biogenesis protein
LXN49_RS08810	COG4846	Membrane protein involved in cytochrome C biogenesis
LXN49_RS08820	COG0071	Belongs to the small heat shock protein (HSP20) family
LXN49_RS08835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LXN49_RS08840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXN49_RS08860	COG0824	Thioesterase
LXN49_RS08870	COG4841	protein insertion into membrane
LXN49_RS08875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LXN49_RS08880	COG1832	CoA-binding protein
LXN49_RS08885	COG0187	DNA topoisomerase II activity
LXN49_RS08890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LXN49_RS08900	COG0738	Major facilitator superfamily
LXN49_RS08905	COG0110	maltose O-acetyltransferase activity
LXN49_RS08910	COG2249	NAD(P)H dehydrogenase (quinone) activity
LXN49_RS08915	COG1733	regulation of RNA biosynthetic process
LXN49_RS08920	COG1012	belongs to the aldehyde dehydrogenase family
LXN49_RS08925	COG0235	Class ii aldolase
LXN49_RS08930	COG1349	DNA-binding transcription factor activity
LXN49_RS08935	COG3254	rhamnose metabolic process
LXN49_RS08940	COG2814	Major facilitator Superfamily
LXN49_RS08950	COG1139	Iron-sulfur cluster binding protein
LXN49_RS08955	COG0247	lactate metabolic process
LXN49_RS08960	COG4806	L-rhamnose isomerase
LXN49_RS08965	COG1070	Carbohydrate kinase
LXN49_RS08970	COG3292	Two component regulator propeller
LXN49_RS08970	COG2205	protein histidine kinase activity
LXN49_RS08970	COG0745	RESPONSE REGULATOR receiver
LXN49_RS08975	COG2197	response regulator
LXN49_RS08980	COG4585	Histidine kinase
LXN49_RS08985	COG2409	Drug exporters of the RND superfamily
LXN49_RS08990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LXN49_RS08995	COG0251	oxidation-reduction process
LXN49_RS09035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LXN49_RS09050	COG0583	DNA-binding transcription factor activity
LXN49_RS09070	COG0657	acetylesterase activity
LXN49_RS09080	COG2723	6-phospho-beta-galactosidase activity
LXN49_RS09085	COG1263	PTS System
LXN49_RS09085	COG2190	(PTS) system
LXN49_RS09085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS09100	COG2205	protein histidine kinase activity
LXN49_RS09105	COG0745	RESPONSE REGULATOR receiver
LXN49_RS09115	COG3507	Belongs to the glycosyl hydrolase 43 family
LXN49_RS09120	COG1012	belongs to the aldehyde dehydrogenase family
LXN49_RS09125	COG1486	melibiose metabolic process
LXN49_RS09130	COG0395	ABC-type sugar transport system, permease component
LXN49_RS09135	COG1175	transmembrane transport
LXN49_RS09140	COG1653	transport
LXN49_RS09145	COG1609	Transcriptional regulator
LXN49_RS09150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LXN49_RS09165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS09205	COG5444	nuclease activity
LXN49_RS09210	COG1846	Transcriptional regulator
LXN49_RS09215	COG2814	Major facilitator Superfamily
LXN49_RS09225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXN49_RS09225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXN49_RS09225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS09230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXN49_RS09230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS09230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LXN49_RS09235	COG1105	Belongs to the carbohydrate kinase PfkB family
LXN49_RS09245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LXN49_RS09275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LXN49_RS09280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LXN49_RS09285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LXN49_RS09290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LXN49_RS09295	COG1024	Enoyl-CoA hydratase
LXN49_RS09300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LXN49_RS09305	COG0511	ligase activity, forming carbon-carbon bonds
LXN49_RS09310	COG0439	Biotin carboxylase
LXN49_RS09315	COG0318	PFAM AMP-dependent synthetase and ligase
LXN49_RS09320	COG1960	acyl-CoA dehydrogenase activity
LXN49_RS09325	COG1649	PFAM Uncharacterised BCR, COG1649
LXN49_RS09330	COG2365	Tyrosine phosphatase family
LXN49_RS09335	COG1349	DNA-binding transcription factor activity
LXN49_RS09345	COG3835	regulator
LXN49_RS09350	COG0277	FAD linked oxidase domain protein
LXN49_RS09355	COG0247	lactate metabolic process
LXN49_RS09385	COG0166	Belongs to the GPI family
LXN49_RS09390	COG2246	polysaccharide biosynthetic process
LXN49_RS09395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LXN49_RS09400	COG0586	Pfam SNARE associated Golgi protein
LXN49_RS09405	COG1587	Uroporphyrinogen-III synthase
LXN49_RS09415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXN49_RS09435	COG0534	Mate efflux family protein
LXN49_RS09440	COG2027	D-alanyl-D-alanine carboxypeptidase
LXN49_RS09445	COG4677	pectinesterase activity
LXN49_RS09450	COG2323	membrane
LXN49_RS09455	COG2146	nitrite reductase [NAD(P)H] activity
LXN49_RS09460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LXN49_RS09465	COG0243	molybdopterin cofactor binding
LXN49_RS09470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LXN49_RS09475	COG2223	nitrite transmembrane transporter activity
LXN49_RS09480	COG0493	'glutamate synthase
LXN49_RS09485	COG0067	glutamate synthase
LXN49_RS09485	COG0070	glutamate synthase
LXN49_RS09485	COG0069	glutamate synthase activity
LXN49_RS09490	COG0583	DNA-binding transcription factor activity
LXN49_RS09505	COG4978	Transcriptional regulator
LXN49_RS09505	COG0789	Transcriptional regulator
LXN49_RS09510	COG0454	-acetyltransferase
LXN49_RS09515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LXN49_RS09520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LXN49_RS09535	COG0243	molybdopterin cofactor binding
LXN49_RS09545	COG1070	Carbohydrate kinase
LXN49_RS09550	COG2115	Belongs to the xylose isomerase family
LXN49_RS09565	COG2211	Major facilitator Superfamily
LXN49_RS09570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LXN49_RS09575	COG1994	Peptidase M50
LXN49_RS09595	COG1309	transcriptional regulator
LXN49_RS09600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LXN49_RS09605	COG3708	Transcriptional regulator
LXN49_RS09610	COG2378	regulation of single-species biofilm formation
LXN49_RS09620	COG0640	Transcriptional regulator
LXN49_RS09625	COG0531	amino acid
LXN49_RS09630	COG0741	lytic transglycosylase activity
LXN49_RS09635	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LXN49_RS09640	COG2079	MmgE PrpD family protein
LXN49_RS09645	COG0372	Belongs to the citrate synthase family
LXN49_RS09650	COG2322	membrane
LXN49_RS09660	COG1388	LysM domain
LXN49_RS09660	COG3584	3D domain protein
LXN49_RS09665	COG0514	ATP-dependent DNA helicase (RecQ)
LXN49_RS09675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LXN49_RS09700	COG1012	belongs to the aldehyde dehydrogenase family
LXN49_RS09705	COG1657	PFAM Prenyltransferase squalene oxidase
LXN49_RS09710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LXN49_RS09715	COG0385	Bile acid
LXN49_RS09720	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXN49_RS09725	COG0567	Dehydrogenase, E1 component
LXN49_RS09730	COG4548	von Willebrand factor, type A
LXN49_RS09735	COG0714	Associated with various cellular activities
LXN49_RS09740	COG2032	superoxide dismutase activity
LXN49_RS09745	COG0791	NLP P60 protein
LXN49_RS09745	COG1388	LysM domain
LXN49_RS09750	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LXN49_RS09755	COG0534	Mate efflux family protein
LXN49_RS09760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LXN49_RS09765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LXN49_RS09775	COG2962	Rard protein
LXN49_RS09790	COG1733	regulation of RNA biosynthetic process
LXN49_RS09795	COG0778	Nitroreductase
LXN49_RS09805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LXN49_RS09810	COG3409	Peptidoglycan-binding domain 1 protein
LXN49_RS09810	COG0793	Belongs to the peptidase S41A family
LXN49_RS09815	COG2226	methyltransferase
LXN49_RS09825	COG1876	peptidase activity
LXN49_RS09830	COG0813	purine-nucleoside phosphorylase activity
LXN49_RS09840	COG0671	phosphoesterase, PA-phosphatase related
LXN49_RS09855	COG4479	Belongs to the UPF0346 family
LXN49_RS09865	COG1509	lysine 2,3-aminomutase activity
LXN49_RS09870	COG3829	transcription factor binding
LXN49_RS09875	COG0463	Glycosyl transferase, family 2
LXN49_RS09890	COG4641	Protein conserved in bacteria
LXN49_RS09900	COG1086	Polysaccharide biosynthesis protein
LXN49_RS09905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LXN49_RS09910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LXN49_RS09915	COG1846	Transcriptional regulator
LXN49_RS09935	COG4698	Protein conserved in bacteria
LXN49_RS09940	COG2755	lipolytic protein G-D-S-L family
LXN49_RS09945	COG1999	signal sequence binding
LXN49_RS09960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LXN49_RS09965	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LXN49_RS09970	COG1272	protein, Hemolysin III
LXN49_RS09975	COG0204	Acyl-transferase
LXN49_RS09980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LXN49_RS09985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LXN49_RS09990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LXN49_RS10000	COG2521	methyltransferase
LXN49_RS10000	COG2136	Putative SAM-dependent methyltransferase
LXN49_RS10010	COG0129	dihydroxy-acid dehydratase activity
LXN49_RS10015	COG1413	lyase activity
LXN49_RS10020	COG1418	mRNA catabolic process
LXN49_RS10025	COG0386	Belongs to the glutathione peroxidase family
LXN49_RS10030	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LXN49_RS10035	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LXN49_RS10040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LXN49_RS10050	COG1278	Cold shock
LXN49_RS10065	COG0328	RNA-DNA hybrid ribonuclease activity
LXN49_RS10070	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LXN49_RS10075	COG0328	RNA-DNA hybrid ribonuclease activity
LXN49_RS10085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LXN49_RS10095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LXN49_RS10100	COG1755	Isoprenylcysteine carboxyl methyltransferase
LXN49_RS10105	COG3424	synthase
LXN49_RS10115	COG0726	polysaccharide deacetylase
LXN49_RS10120	COG2233	PERMEase
LXN49_RS10125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LXN49_RS10130	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LXN49_RS10135	COG1199	ATP-dependent helicase activity
LXN49_RS10145	COG0116	Belongs to the methyltransferase superfamily
LXN49_RS10155	COG3599	regulation of cell shape
LXN49_RS10160	COG4474	Belongs to the UPF0398 family
LXN49_RS10170	COG3359	exonuclease
LXN49_RS10175	COG1111	helicase
LXN49_RS10175	COG1205	dead DEAH box helicase
LXN49_RS10180	COG1902	pentaerythritol trinitrate reductase activity
LXN49_RS10185	COG2190	(PTS) system
LXN49_RS10190	COG0071	Belongs to the small heat shock protein (HSP20) family
LXN49_RS10220	COG3331	DNA recombination
LXN49_RS10225	COG4499	WXG100 protein secretion system (Wss), protein YukC
LXN49_RS10225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LXN49_RS10235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LXN49_RS10240	COG3935	DnaD domain protein
LXN49_RS10245	COG0017	Asparaginyl-tRNA synthetase
LXN49_RS10250	COG5353	protein conserved in bacteria
LXN49_RS10260	COG1199	ATP-dependent helicase activity
LXN49_RS10260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LXN49_RS10265	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LXN49_RS10270	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LXN49_RS10275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LXN49_RS10285	COG0617	tRNA 3'-terminal CCA addition
LXN49_RS10290	COG0438	transferase activity, transferring glycosyl groups
LXN49_RS10295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LXN49_RS10300	COG1803	Methylglyoxal synthase
LXN49_RS10305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LXN49_RS10310	COG1694	Mazg nucleotide pyrophosphohydrolase
LXN49_RS10315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LXN49_RS10325	COG4347	Protein of unknown function (DUF1405)
LXN49_RS10330	COG2010	Cytochrome c
LXN49_RS10330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LXN49_RS10335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LXN49_RS10340	COG0723	plastoquinol--plastocyanin reductase activity
LXN49_RS10350	COG5582	Belongs to the UPF0302 family
LXN49_RS10355	COG0457	Tetratricopeptide repeat
LXN49_RS10360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LXN49_RS10365	COG0287	Prephenate dehydrogenase
LXN49_RS10370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LXN49_RS10375	COG0159	tryptophan synthase activity
LXN49_RS10380	COG0133	tryptophan synthase activity
LXN49_RS10390	COG0134	indole-3-glycerol-phosphate synthase activity
LXN49_RS10405	COG4401	Chorismate mutase type I
LXN49_RS10410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LXN49_RS10415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LXN49_RS10420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LXN49_RS10425	COG0105	UTP biosynthetic process
LXN49_RS10430	COG0142	geranyltranstransferase activity
LXN49_RS10435	COG2226	methyltransferase
LXN49_RS10440	COG0142	geranyltranstransferase activity
LXN49_RS10450	COG0302	gtp cyclohydrolase
LXN49_RS10455	COG0776	regulation of translation
LXN49_RS10460	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LXN49_RS10475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LXN49_RS10480	COG1160	GTP binding
LXN49_RS10505	COG1304	FMN binding
LXN49_RS10510	COG0539	negative regulation of cytoplasmic translation
LXN49_RS10515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LXN49_RS10525	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LXN49_RS10530	COG2959	enzyme of heme biosynthesis
LXN49_RS10535	COG3409	Peptidoglycan-binding domain 1 protein
LXN49_RS10535	COG3773	Cell wall hydrolase
LXN49_RS10540	COG2339	peptidase activity
LXN49_RS10545	COG0492	ferredoxin-NADP+ reductase activity
LXN49_RS10550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LXN49_RS10555	COG4862	establishment of competence for transformation
LXN49_RS10560	COG1408	metallophosphoesterase
LXN49_RS10570	COG1388	LysM domain
LXN49_RS10575	COG1266	CAAX protease self-immunity
LXN49_RS10580	COG0514	ATP-dependent DNA helicase (RecQ)
LXN49_RS10585	COG4955	Helix-turn-helix domain
LXN49_RS10590	COG1141	Ferredoxin
LXN49_RS10595	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LXN49_RS10600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LXN49_RS10605	COG3409	Peptidoglycan-binding domain 1 protein
LXN49_RS10605	COG5632	N-Acetylmuramoyl-L-alanine amidase
LXN49_RS10615	COG1595	DNA-templated transcription, initiation
LXN49_RS10620	COG5002	protein histidine kinase activity
LXN49_RS10625	COG0745	RESPONSE REGULATOR receiver
LXN49_RS10630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LXN49_RS10635	COG1333	cytochrome c biogenesis protein
LXN49_RS10640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXN49_RS10645	COG1187	pseudouridine synthase activity
LXN49_RS10650	COG0700	Nucleoside recognition
LXN49_RS10655	COG2715	membrane protein required for spore maturation
LXN49_RS10660	COG1686	Belongs to the peptidase S11 family
LXN49_RS10670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LXN49_RS10675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LXN49_RS10685	COG1547	Domain of unknown function (DUF309)
LXN49_RS10690	COG0456	acetyltransferase
LXN49_RS10695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LXN49_RS10705	COG0307	riboflavin synthase, alpha
LXN49_RS10725	COG2814	Major facilitator Superfamily
LXN49_RS10730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LXN49_RS10735	COG4086	secreted protein
LXN49_RS10740	COG0019	diaminopimelate decarboxylase activity
LXN49_RS10745	COG0697	spore germination
LXN49_RS10760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LXN49_RS10780	COG1191	sigma factor activity
LXN49_RS10785	COG2172	sigma factor antagonist activity
LXN49_RS10795	COG1686	Belongs to the peptidase S11 family
LXN49_RS10800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LXN49_RS10805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LXN49_RS10810	COG4974	Belongs to the 'phage' integrase family
LXN49_RS10820	COG0735	belongs to the Fur family
LXN49_RS10825	COG1300	Membrane
LXN49_RS10830	COG1404	Belongs to the peptidase S8 family
LXN49_RS10840	COG2153	protein acetylation
LXN49_RS10845	COG1379	DNA repair
LXN49_RS10850	COG0494	nUDIX hydrolase
LXN49_RS10855	COG0667	Aldo Keto reductase
LXN49_RS10870	COG1073	alpha beta
LXN49_RS10875	COG0457	Tetratricopeptide repeat
LXN49_RS10890	COG4918	Iron-sulphur cluster biosynthesis
LXN49_RS10895	COG0456	acetyltransferase
LXN49_RS10895	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LXN49_RS10900	COG0456	acetyltransferase
LXN49_RS10910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LXN49_RS10920	COG2211	Major facilitator Superfamily
LXN49_RS10925	COG1072	(Pantothenic acid kinase))
LXN49_RS10930	COG0446	pyridine nucleotide-disulphide oxidoreductase
LXN49_RS10935	COG0300	oxidoreductase activity
LXN49_RS10940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LXN49_RS10945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LXN49_RS10965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LXN49_RS10970	COG4187	Peptidase family M20/M25/M40
LXN49_RS10975	COG1902	pentaerythritol trinitrate reductase activity
LXN49_RS10980	COG0596	Alpha beta hydrolase
LXN49_RS10985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LXN49_RS10995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LXN49_RS11000	COG2188	Transcriptional regulator
LXN49_RS11005	COG2723	6-phospho-beta-galactosidase activity
LXN49_RS11010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LXN49_RS11015	COG1447	Phosphotransferase system cellobiose-specific component IIA
LXN49_RS11020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LXN49_RS11025	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS11035	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LXN49_RS11040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LXN49_RS11055	COG0706	membrane insertase activity
LXN49_RS11065	COG2195	Cleaves the N-terminal amino acid of tripeptides
LXN49_RS11070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LXN49_RS11075	COG0346	lactoylglutathione lyase activity
LXN49_RS11085	COG1376	ErfK ybiS ycfS ynhG family protein
LXN49_RS11090	COG4129	membrane
LXN49_RS11095	COG1126	abc transporter atp-binding protein
LXN49_RS11100	COG0765	amino acid transport
LXN49_RS11105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXN49_RS11115	COG1597	lipid kinase activity
LXN49_RS11125	COG0508	dehydrogenase complex catalyzes the overall conversion of
LXN49_RS11130	COG0022	dehydrogenase e1 component
LXN49_RS11135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LXN49_RS11140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LXN49_RS11145	COG3426	butyrate kinase activity
LXN49_RS11150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LXN49_RS11155	COG0280	phosphate acetyltransferase
LXN49_RS11160	COG3290	protein histidine kinase activity
LXN49_RS11160	COG3829	transcription factor binding
LXN49_RS11170	COG0584	glycerophosphoryl diester phosphodiesterase
LXN49_RS11175	COG0457	Tetratricopeptide repeat
LXN49_RS11180	COG0745	RESPONSE REGULATOR receiver
LXN49_RS11185	COG0750	zinc metalloprotease
LXN49_RS11190	COG0497	DNA recombination
LXN49_RS11195	COG1438	arginine binding
LXN49_RS11200	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LXN49_RS11205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LXN49_RS11210	COG0142	geranyltranstransferase activity
LXN49_RS11215	COG1722	exodeoxyribonuclease VII activity
LXN49_RS11220	COG1570	exodeoxyribonuclease VII activity
LXN49_RS11225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LXN49_RS11230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LXN49_RS11235	COG1302	Protein conserved in bacteria
LXN49_RS11240	COG0439	Biotin carboxylase
LXN49_RS11245	COG0511	ligase activity, forming carbon-carbon bonds
LXN49_RS11285	COG3854	ATPases associated with a variety of cellular activities
LXN49_RS11295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LXN49_RS11300	COG0006	proline dipeptidase activity
LXN49_RS11305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LXN49_RS11315	COG3872	metal-dependent enzyme
LXN49_RS11325	COG1752	Esterase of the alpha-beta hydrolase superfamily
LXN49_RS11330	COG1321	iron dependent repressor
LXN49_RS11335	COG0095	Lipoate-protein ligase
LXN49_RS11340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LXN49_RS11345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LXN49_RS11350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LXN49_RS11355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LXN49_RS11360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LXN49_RS11385	COG0681	Belongs to the peptidase S26 family
LXN49_RS11415	COG4970	Tfp pilus assembly protein FimT
LXN49_RS11420	COG4537	Required for transformation and DNA binding
LXN49_RS11425	COG1459	type II secretion system
LXN49_RS11430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LXN49_RS11435	COG1366	Belongs to the anti-sigma-factor antagonist family
LXN49_RS11445	COG1393	Belongs to the ArsC family
LXN49_RS11455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LXN49_RS11465	COG0011	TIGRFAM Protein of
LXN49_RS11470	COG2814	Major facilitator Superfamily
LXN49_RS11475	COG2866	Carboxypeptidase
LXN49_RS11480	COG1368	sulfuric ester hydrolase activity
LXN49_RS11485	COG1940	carbohydrate kinase activity
LXN49_RS11490	COG4483	Protein conserved in bacteria
LXN49_RS11495	COG0705	Rhomboid family
LXN49_RS11495	COG0457	Tetratricopeptide repeat
LXN49_RS11510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LXN49_RS11515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LXN49_RS11525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LXN49_RS11530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LXN49_RS11535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LXN49_RS11540	COG0581	inorganic phosphate transmembrane transporter activity
LXN49_RS11545	COG0573	inorganic phosphate transmembrane transporter activity
LXN49_RS11550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LXN49_RS11555	COG0768	penicillin binding
LXN49_RS11560	COG0477	Major facilitator Superfamily
LXN49_RS11565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LXN49_RS11570	COG2839	Protein conserved in bacteria
LXN49_RS11575	COG5521	maltodextrose utilization protein MalA
LXN49_RS11580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LXN49_RS11585	COG1388	LysM domain
LXN49_RS11590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LXN49_RS11595	COG4709	membrane
LXN49_RS11600	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
LXN49_RS11605	COG1940	carbohydrate kinase activity
LXN49_RS11610	COG0735	belongs to the Fur family
LXN49_RS11615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LXN49_RS11620	COG1121	(ABC) transporter
LXN49_RS11625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LXN49_RS11640	COG0513	Belongs to the DEAD box helicase family
LXN49_RS11650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LXN49_RS11655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LXN49_RS11660	COG2384	SAM-dependent methyltransferase
LXN49_RS11665	COG2010	Cytochrome c
LXN49_RS11670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LXN49_RS11675	COG0358	DNA primase activity
LXN49_RS11680	COG1671	Belongs to the UPF0178 family
LXN49_RS11685	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LXN49_RS11690	COG0517	IMP dehydrogenase activity
LXN49_RS11695	COG0751	glycine-tRNA ligase activity
LXN49_RS11700	COG0752	glycyl-tRNA synthetase alpha subunit
LXN49_RS11705	COG1381	Involved in DNA repair and RecF pathway recombination
LXN49_RS11715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LXN49_RS11720	COG0295	cytidine deaminase activity
LXN49_RS11725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LXN49_RS11730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LXN49_RS11735	COG1480	7TM receptor with intracellular HD hydrolase
LXN49_RS11740	COG1702	phosphate starvation-inducible protein PhoH
LXN49_RS11745	COG0561	phosphatase activity
LXN49_RS11760	COG4864	UPF0365 protein
LXN49_RS11765	COG1030	water channel activity
LXN49_RS11770	COG1610	YqeY-like protein
LXN49_RS11780	COG1283	sodium-dependent phosphate transmembrane transporter activity
LXN49_RS11785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LXN49_RS11790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LXN49_RS11795	COG2264	protein methyltransferase activity
LXN49_RS11800	COG0484	heat shock protein binding
LXN49_RS11805	COG0443	Heat shock 70 kDa protein
LXN49_RS11810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LXN49_RS11815	COG1420	regulation of RNA biosynthetic process
LXN49_RS11820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LXN49_RS11825	COG0481	GTPase activity
LXN49_RS11835	COG0860	N-Acetylmuramoyl-L-alanine amidase
LXN49_RS11840	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LXN49_RS11845	COG0268	Binds directly to 16S ribosomal RNA
LXN49_RS11850	COG1466	dna polymerase III delta subunit
LXN49_RS11860	COG2333	competence protein COMEC
LXN49_RS11860	COG0658	competence protein
LXN49_RS11865	COG2131	deaminase
LXN49_RS11870	COG1555	photosystem II stabilization
LXN49_RS11875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LXN49_RS11880	COG2226	methyltransferase
LXN49_RS11885	COG0799	negative regulation of ribosome biogenesis
LXN49_RS11890	COG1713	HD superfamily hydrolase involved in NAD metabolism
LXN49_RS11895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LXN49_RS11900	COG1534	Rna-binding protein
LXN49_RS11905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LXN49_RS11910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LXN49_RS11915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LXN49_RS11930	COG2755	lipolytic protein G-D-S-L family
LXN49_RS11940	COG0457	Tetratricopeptide repeat
LXN49_RS11950	COG2186	Transcriptional regulator
LXN49_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS11970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LXN49_RS11975	COG3959	Transketolase, thiamine diphosphate binding domain
LXN49_RS12000	COG0726	polysaccharide deacetylase
LXN49_RS12030	COG2160	L-arabinose isomerase activity
LXN49_RS12045	COG1609	Transcriptional regulator
LXN49_RS12055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LXN49_RS12060	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
LXN49_RS12065	COG1733	regulation of RNA biosynthetic process
LXN49_RS12070	COG0657	acetylesterase activity
LXN49_RS12090	COG2602	Beta-lactamase
LXN49_RS12095	COG1960	acyl-CoA dehydrogenase activity
LXN49_RS12100	COG1126	abc transporter atp-binding protein
LXN49_RS12110	COG0765	amino acid transport
LXN49_RS12120	COG3546	catalase activity
LXN49_RS12125	COG1063	alcohol dehydrogenase
LXN49_RS12135	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS12140	COG1132	(ABC) transporter
LXN49_RS12145	COG0454	-acetyltransferase
LXN49_RS12150	COG2226	methyltransferase
LXN49_RS12155	COG1063	alcohol dehydrogenase
LXN49_RS12160	COG2226	methyltransferase
LXN49_RS12185	COG0626	cystathionine gamma-synthase activity
LXN49_RS12190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LXN49_RS12195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LXN49_RS12200	COG2226	methyltransferase
LXN49_RS12215	COG0768	penicillin binding
LXN49_RS12220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LXN49_RS12230	COG0572	uridine kinase
LXN49_RS12235	COG0826	peptidase U32
LXN49_RS12240	COG0826	peptidase U32
LXN49_RS12245	COG4122	O-methyltransferase activity
LXN49_RS12250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LXN49_RS12255	COG0183	Belongs to the thiolase family
LXN49_RS12260	COG0318	PFAM AMP-dependent synthetase and ligase
LXN49_RS12265	COG1268	BioY protein
LXN49_RS12270	COG3906	Belongs to the UPF0473 family
LXN49_RS12275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LXN49_RS12280	COG4472	Bacterial protein of unknown function (DUF965)
LXN49_RS12285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LXN49_RS12290	COG0628	permease
LXN49_RS12295	COG1126	abc transporter atp-binding protein
LXN49_RS12300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXN49_RS12305	COG0765	amino acid transport
LXN49_RS12310	COG0765	amino acid transport
LXN49_RS12325	COG3881	PFAM PRC-barrel domain
LXN49_RS12330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LXN49_RS12335	COG0457	Tetratricopeptide repeat
LXN49_RS12340	COG0482	sulfurtransferase activity
LXN49_RS12345	COG1104	cysteine desulfurase activity
LXN49_RS12350	COG1959	2 iron, 2 sulfur cluster binding
LXN49_RS12355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LXN49_RS12360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LXN49_RS12375	COG0124	histidyl-tRNA synthetase
LXN49_RS12385	COG0860	N-Acetylmuramoyl-L-alanine amidase
LXN49_RS12385	COG4991	sh3 domain protein
LXN49_RS12385	COG3103	Sh3 type 3 domain protein
LXN49_RS12390	COG1490	D-aminoacyl-tRNA deacylase activity
LXN49_RS12395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LXN49_RS12400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LXN49_RS12405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LXN49_RS12405	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LXN49_RS12410	COG5416	Lipopolysaccharide assembly protein A domain
LXN49_RS12415	COG0490	domain, Protein
LXN49_RS12420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LXN49_RS12420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LXN49_RS12430	COG2244	polysaccharide biosynthetic process
LXN49_RS12435	COG2323	membrane
LXN49_RS12445	COG1862	Preprotein translocase
LXN49_RS12450	COG0343	queuine tRNA-ribosyltransferase activity
LXN49_RS12455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LXN49_RS12465	COG2255	four-way junction helicase activity
LXN49_RS12470	COG0632	four-way junction helicase activity
LXN49_RS12480	COG2112	serine threonine protein kinase
LXN49_RS12495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LXN49_RS12515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LXN49_RS12520	COG0157	Belongs to the NadC ModD family
LXN49_RS12525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LXN49_RS12530	COG1104	cysteine desulfurase activity
LXN49_RS12535	COG1827	regulation of RNA biosynthetic process
LXN49_RS12540	COG0077	Prephenate dehydratase
LXN49_RS12545	COG4492	Belongs to the UPF0735 family
LXN49_RS12550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LXN49_RS12555	COG3290	protein histidine kinase activity
LXN49_RS12560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LXN49_RS12565	COG2868	ribosomal protein
LXN49_RS12570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LXN49_RS12575	COG1994	Peptidase M50
LXN49_RS12580	COG0739	heme binding
LXN49_RS12585	COG2894	cell division
LXN49_RS12590	COG0850	regulation of cytokinetic process
LXN49_RS12595	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LXN49_RS12605	COG1077	Cell shape determining protein MreB Mrl
LXN49_RS12610	COG2003	Belongs to the UPF0758 family
LXN49_RS12615	COG0424	maF-like protein
LXN49_RS12625	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LXN49_RS12630	COG0285	dihydrofolate synthase activity
LXN49_RS12635	COG0525	valine-tRNA ligase activity
LXN49_RS12645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LXN49_RS12650	COG1388	LysM domain
LXN49_RS12655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LXN49_RS12660	COG0113	porphobilinogen synthase activity
LXN49_RS12665	COG1587	Uroporphyrinogen-III synthase
LXN49_RS12670	COG0181	hydroxymethylbilane synthase activity
LXN49_RS12675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LXN49_RS12680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LXN49_RS12690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LXN49_RS12695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LXN49_RS12700	COG0470	DNA polymerase III
LXN49_RS12700	COG1067	ATP-dependent peptidase activity
LXN49_RS12705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LXN49_RS12710	COG0544	peptidyl-prolyl cis-trans isomerase activity
LXN49_RS12715	COG0457	Tetratricopeptide repeat
LXN49_RS12715	COG1477	protein flavinylation
LXN49_RS12720	COG0066	3-isopropylmalate dehydratase activity
LXN49_RS12725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LXN49_RS12730	COG0473	3-isopropylmalate dehydrogenase activity
LXN49_RS12735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LXN49_RS12740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LXN49_RS12745	COG0440	acetolactate synthase activity
LXN49_RS12750	COG0028	Belongs to the TPP enzyme family
LXN49_RS12755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LXN49_RS12760	COG2706	6-phosphogluconolactonase activity
LXN49_RS12765	COG3339	Conserved Protein
LXN49_RS12770	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LXN49_RS12775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LXN49_RS12780	COG1696	Membrane protein involved in D-alanine export
LXN49_RS12785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LXN49_RS12815	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS12825	COG0622	Phosphoesterase
LXN49_RS12830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LXN49_RS12835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LXN49_RS12840	COG5401	PFAM Sporulation and spore germination
LXN49_RS12845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LXN49_RS12850	COG1846	Transcriptional regulator
LXN49_RS12855	COG2197	response regulator
LXN49_RS12860	COG2851	Citrate transporter
LXN49_RS12865	COG0583	DNA-binding transcription factor activity
LXN49_RS12870	COG2828	Protein conserved in bacteria
LXN49_RS12880	COG0824	Thioesterase
LXN49_RS12885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LXN49_RS12890	COG1053	succinate dehydrogenase
LXN49_RS12895	COG2009	succinate dehydrogenase
LXN49_RS12900	COG1719	4-vinyl reductase, 4VR
LXN49_RS12905	COG0527	aspartate kinase activity
LXN49_RS12910	COG0322	excinuclease ABC activity
LXN49_RS12915	COG3118	belongs to the thioredoxin family
LXN49_RS12920	COG3534	alpha-L-arabinofuranosidase
LXN49_RS12925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LXN49_RS12930	COG2086	electron transfer activity
LXN49_RS12935	COG1024	Enoyl-CoA hydratase
LXN49_RS12940	COG1309	transcriptional regulator
LXN49_RS12945	COG0318	PFAM AMP-dependent synthetase and ligase
LXN49_RS12955	COG3766	membrane
LXN49_RS12960	COG1193	negative regulation of DNA recombination
LXN49_RS12965	COG1796	DNA polymerase
LXN49_RS12965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LXN49_RS12970	COG1286	toxin biosynthetic process
LXN49_RS12975	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LXN49_RS12980	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LXN49_RS12985	COG0072	phenylalanine-tRNA ligase activity
LXN49_RS12985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LXN49_RS12990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LXN49_RS12995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LXN49_RS13005	COG1966	Carbon starvation protein
LXN49_RS13010	COG1363	Peptidase, m42
LXN49_RS13020	COG3326	Membrane
LXN49_RS13025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LXN49_RS13030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LXN49_RS13035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LXN49_RS13040	COG1346	cytolysis
LXN49_RS13050	COG3279	Response regulator of the LytR AlgR family
LXN49_RS13055	COG3275	phosphorelay sensor kinase activity
LXN49_RS13060	COG1011	Hydrolase
LXN49_RS13070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LXN49_RS13080	COG0398	Pfam SNARE associated Golgi protein
LXN49_RS13085	COG1484	DNA-dependent DNA replication
LXN49_RS13090	COG3611	Membrane attachment protein
LXN49_RS13095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LXN49_RS13105	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LXN49_RS13110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LXN49_RS13115	COG0237	dephospho-CoA kinase activity
LXN49_RS13120	COG1971	Probably functions as a manganese efflux pump
LXN49_RS13125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LXN49_RS13130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LXN49_RS13130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LXN49_RS13135	COG5002	protein histidine kinase activity
LXN49_RS13140	COG0745	RESPONSE REGULATOR receiver
LXN49_RS13145	COG0039	L-malate dehydrogenase activity
LXN49_RS13150	COG0538	isocitrate dehydrogenase activity
LXN49_RS13155	COG0372	Belongs to the citrate synthase family
LXN49_RS13160	COG2707	UPF0756 membrane protein
LXN49_RS13165	COG0628	permease
LXN49_RS13170	COG3030	protein affecting phage T7 exclusion by the F plasmid
LXN49_RS13180	COG0205	6-phosphofructokinase activity
LXN49_RS13185	COG0825	malonyl-CoA metabolic process
LXN49_RS13190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LXN49_RS13195	COG0281	malic enzyme
LXN49_RS13200	COG0587	DNA-directed DNA polymerase activity
LXN49_RS13220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LXN49_RS13230	COG4109	DRTGG domain
LXN49_RS13235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LXN49_RS13240	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS13250	COG0165	Argininosuccinate lyase
LXN49_RS13255	COG0137	argininosuccinate synthase activity
LXN49_RS13260	COG0521	Mo-molybdopterin cofactor biosynthetic process
LXN49_RS13265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LXN49_RS13270	COG0827	DNA restriction-modification system
LXN49_RS13275	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LXN49_RS13280	COG3874	Sporulation protein YtfJ
LXN49_RS13290	COG1714	RDD family
LXN49_RS13295	COG0616	signal peptide processing
LXN49_RS13300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LXN49_RS13310	COG3239	Fatty acid desaturase
LXN49_RS13315	COG4585	Histidine kinase
LXN49_RS13320	COG2197	response regulator
LXN49_RS13325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LXN49_RS13330	COG0745	RESPONSE REGULATOR receiver
LXN49_RS13335	COG0642	Histidine kinase
LXN49_RS13340	COG0772	Belongs to the SEDS family
LXN49_RS13345	COG1695	Transcriptional regulator
LXN49_RS13350	COG1136	(ABC) transporter
LXN49_RS13355	COG0577	efflux transmembrane transporter activity
LXN49_RS13360	COG0402	S-adenosylhomocysteine deaminase activity
LXN49_RS13375	COG1279	arginine transmembrane transporter activity
LXN49_RS13380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LXN49_RS13390	COG0301	tRNA thio-modification
LXN49_RS13395	COG1104	cysteine desulfurase activity
LXN49_RS13400	COG1114	Component of the transport system for branched-chain amino acids
LXN49_RS13405	COG1114	Component of the transport system for branched-chain amino acids
LXN49_RS13410	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LXN49_RS13415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LXN49_RS13420	COG1309	transcriptional regulator
LXN49_RS13425	COG1956	GAF domain-containing protein
LXN49_RS13430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LXN49_RS13440	COG1335	isochorismatase
LXN49_RS13445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LXN49_RS13465	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LXN49_RS13470	COG2329	Antibiotic biosynthesis monooxygenase
LXN49_RS13475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LXN49_RS13480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LXN49_RS13485	COG0454	-acetyltransferase
LXN49_RS13490	COG0517	IMP dehydrogenase activity
LXN49_RS13495	COG0123	including yeast histone deacetylase and acetoin utilization protein
LXN49_RS13500	COG1609	Transcriptional regulator
LXN49_RS13505	COG1605	Chorismate mutase
LXN49_RS13505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LXN49_RS13510	COG3118	belongs to the thioredoxin family
LXN49_RS13515	COG4980	gas vesicle protein
LXN49_RS13520	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
LXN49_RS13525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LXN49_RS13530	COG1674	ftsk spoiiie
LXN49_RS13535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LXN49_RS13540	COG4848	Belongs to the UPF0354 family
LXN49_RS13545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXN49_RS13560	COG1363	Peptidase, m42
LXN49_RS13565	COG5584	Small secreted protein
LXN49_RS13570	COG0281	malic enzyme
LXN49_RS13575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LXN49_RS13580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LXN49_RS13590	COG0510	thiamine kinase activity
LXN49_RS13595	COG1597	lipid kinase activity
LXN49_RS13605	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LXN49_RS13610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LXN49_RS13615	COG3340	Belongs to the peptidase S51 family
LXN49_RS13620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LXN49_RS13625	COG2252	PERMEase
LXN49_RS13630	COG1349	DNA-binding transcription factor activity
LXN49_RS13635	COG1187	pseudouridine synthase activity
LXN49_RS13640	COG2244	polysaccharide biosynthetic process
LXN49_RS13645	COG2081	HI0933 family
LXN49_RS13655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LXN49_RS13660	COG3196	Protein conserved in bacteria
LXN49_RS13670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LXN49_RS13675	COG5578	integral membrane protein
LXN49_RS13680	COG0673	inositol 2-dehydrogenase activity
LXN49_RS13685	COG1653	transport
LXN49_RS13690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LXN49_RS13695	COG4209	transmembrane transport
LXN49_RS13700	COG2207	Transcriptional regulator
LXN49_RS13705	COG1733	regulation of RNA biosynthetic process
LXN49_RS13710	COG2814	Major facilitator Superfamily
LXN49_RS13715	COG0656	L-ascorbic acid biosynthetic process
LXN49_RS13720	COG1653	transport
LXN49_RS13725	COG0395	ABC-type sugar transport system, permease component
LXN49_RS13730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LXN49_RS13735	COG1073	alpha beta
LXN49_RS13740	COG0495	leucyl-tRNA aminoacylation
LXN49_RS13750	COG1366	Belongs to the anti-sigma-factor antagonist family
LXN49_RS13750	COG2202	Pas domain
LXN49_RS13755	COG2433	Pfam Transposase IS66
LXN49_RS13760	COG0577	efflux transmembrane transporter activity
LXN49_RS13765	COG1136	(ABC) transporter
LXN49_RS13775	COG1131	(ABC) transporter
LXN49_RS13780	COG1725	Transcriptional regulator
LXN49_RS13795	COG1242	4 iron, 4 sulfur cluster binding
LXN49_RS13800	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LXN49_RS13810	COG2267	carboxylic ester hydrolase activity
LXN49_RS13815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LXN49_RS13820	COG0367	asparagine synthase
LXN49_RS13825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LXN49_RS13830	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LXN49_RS13840	COG1506	peptidase
LXN49_RS13845	COG1233	COG1233 Phytoene dehydrogenase and related
LXN49_RS13865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LXN49_RS13870	COG1116	anion transmembrane transporter activity
LXN49_RS13875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LXN49_RS13880	COG0494	nUDIX hydrolase
LXN49_RS13885	COG2310	stress, protein
LXN49_RS13900	COG4824	toxin secretion phage lysis holin
LXN49_RS13910	COG0783	Belongs to the Dps family
LXN49_RS13925	COG1854	S-ribosylhomocysteine lyase activity
LXN49_RS13930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LXN49_RS13935	COG0288	reversible hydration of carbon dioxide
LXN49_RS13940	COG0803	Belongs to the bacterial solute-binding protein 9 family
LXN49_RS13940	COG3443	Belongs to the bacterial solute-binding protein 9 family
LXN49_RS13945	COG0254	rRNA binding
LXN49_RS13950	COG1271	oxidase subunit
LXN49_RS13955	COG1294	oxidase, subunit
LXN49_RS13970	COG4948	Mandelate Racemase Muconate Lactonizing
LXN49_RS13975	COG0318	PFAM AMP-dependent synthetase and ligase
LXN49_RS13980	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LXN49_RS13985	COG0596	Alpha beta hydrolase
LXN49_RS13990	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LXN49_RS13995	COG1169	isochorismate synthase
LXN49_RS14000	COG1575	Belongs to the MenA family. Type 1 subfamily
LXN49_RS14005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LXN49_RS14135	COG3859	Proton-coupled thiamine transporter YuaJ
LXN49_RS14140	COG1247	-acetyltransferase
LXN49_RS14145	COG2268	Band 7 protein
LXN49_RS14150	COG1585	Membrane protein implicated in regulation of membrane protease activity
LXN49_RS14155	COG2318	DinB family
LXN49_RS14160	COG1454	alcohol dehydrogenase
LXN49_RS14165	COG1012	belongs to the aldehyde dehydrogenase family
LXN49_RS14170	COG1510	regulation of RNA biosynthetic process
LXN49_RS14180	COG3409	Peptidoglycan-binding domain 1 protein
LXN49_RS14180	COG5632	N-Acetylmuramoyl-L-alanine amidase
LXN49_RS14235	COG3778	Protein conserved in bacteria
LXN49_RS14240	COG3299	homolog of phage Mu protein gp47
LXN49_RS14245	COG3628	GPW Gp25 family protein
LXN49_RS14255	COG4193	domain, Protein
LXN49_RS14260	COG1652	LysM domain
LXN49_RS14265	COG3953	SLT domain
LXN49_RS14265	COG5280	Phage tail tape measure protein TP901
LXN49_RS14315	COG4653	Phage capsid family
LXN49_RS14320	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LXN49_RS14325	COG5518	Phage portal protein
LXN49_RS14330	COG1783	phage Terminase large subunit
LXN49_RS14335	COG5484	DNA packaging
LXN49_RS14340	COG1595	DNA-templated transcription, initiation
LXN49_RS14350	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
LXN49_RS14370	COG1396	sequence-specific DNA binding
LXN49_RS14380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LXN49_RS14390	COG1968	undecaprenyl-diphosphatase activity
LXN49_RS14395	COG0628	permease
LXN49_RS14405	COG0673	inositol 2-dehydrogenase activity
LXN49_RS14410	COG0693	protein deglycase activity
LXN49_RS14415	COG0840	transmembrane signaling receptor activity
LXN49_RS14420	COG0840	transmembrane signaling receptor activity
LXN49_RS14425	COG0840	transmembrane signaling receptor activity
LXN49_RS14430	COG0840	transmembrane signaling receptor activity
LXN49_RS14445	COG2070	2-Nitropropane dioxygenase
LXN49_RS14450	COG0432	Pfam Uncharacterised protein family UPF0047
LXN49_RS14455	COG1253	flavin adenine dinucleotide binding
LXN49_RS14460	COG2738	Putative neutral zinc metallopeptidase
LXN49_RS14470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LXN49_RS14485	COG0166	Belongs to the GPI family
LXN49_RS14490	COG1979	alcohol dehydrogenase
LXN49_RS14495	COG1979	alcohol dehydrogenase
LXN49_RS14500	COG2155	Conserved Protein
LXN49_RS14505	COG1098	S1 RNA binding domain
LXN49_RS14510	COG0436	Aminotransferase
LXN49_RS14515	COG1522	sequence-specific DNA binding
LXN49_RS14520	COG2267	carboxylic ester hydrolase activity
LXN49_RS14530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LXN49_RS14535	COG2205	protein histidine kinase activity
LXN49_RS14550	COG5018	Exonuclease
LXN49_RS14555	COG2814	Major facilitator Superfamily
LXN49_RS14560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LXN49_RS14565	COG3011	Protein conserved in bacteria
LXN49_RS14575	COG3290	protein histidine kinase activity
LXN49_RS14580	COG4565	transcriptional regulatory protein
LXN49_RS14585	COG1744	ABC transporter substrate-binding protein PnrA-like
LXN49_RS14590	COG3845	ABC transporter
LXN49_RS14595	COG4603	Belongs to the binding-protein-dependent transport system permease family
LXN49_RS14600	COG1079	Belongs to the binding-protein-dependent transport system permease family
LXN49_RS14605	COG3493	citrate carrier protein
LXN49_RS14615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LXN49_RS14615	COG2111	Na H antiporter
LXN49_RS14620	COG2111	Na H antiporter
LXN49_RS14625	COG1006	Multisubunit Na H antiporter MnhC subunit
LXN49_RS14630	COG0651	ATP synthesis coupled electron transport
LXN49_RS14635	COG1863	multisubunit Na H antiporter MnhE subunit
LXN49_RS14640	COG2212	antiporter activity
LXN49_RS14645	COG1320	monovalent cation:proton antiporter activity
LXN49_RS14650	COG2050	protein possibly involved in aromatic compounds catabolism
LXN49_RS14655	COG2197	response regulator
LXN49_RS14660	COG4585	Histidine kinase
LXN49_RS14670	COG0142	geranyltranstransferase activity
LXN49_RS14685	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LXN49_RS14690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LXN49_RS14695	COG1335	isochorismatase
LXN49_RS14700	COG5506	Protein of unknown function (DUF1694)
LXN49_RS14720	COG0628	permease
LXN49_RS14735	COG1418	mRNA catabolic process
LXN49_RS14740	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS14750	COG1511	domain protein
LXN49_RS14755	COG0433	COG0433 Predicted ATPase
LXN49_RS14755	COG1674	ftsk spoiiie
LXN49_RS14760	COG4499	WXG100 protein secretion system (Wss), protein YukC
LXN49_RS14765	COG5417	Belongs to the EsaB family
LXN49_RS14770	COG4842	Belongs to the WXG100 family
LXN49_RS14775	COG2508	Transcriptional regulator
LXN49_RS14775	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LXN49_RS14780	COG0686	Belongs to the AlaDH PNT family
LXN49_RS14785	COG1268	BioY protein
LXN49_RS14790	COG4326	sporulation control protein
LXN49_RS14795	COG2056	Na+-H+ antiporter family
LXN49_RS14800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LXN49_RS14805	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LXN49_RS14810	COG3584	3D domain protein
LXN49_RS14825	COG1252	NADH dehydrogenase
LXN49_RS14830	COG0492	ferredoxin-NADP+ reductase activity
LXN49_RS14840	COG0789	Transcriptional regulator
LXN49_RS14845	COG0316	Belongs to the HesB IscA family
LXN49_RS14850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LXN49_RS14855	COG4844	belongs to the
LXN49_RS14860	COG1252	NADH dehydrogenase
LXN49_RS14870	COG4837	Protein of unknown function (DUF1462)
LXN49_RS14880	COG0823	Involved in the tonB-independent uptake of proteins
LXN49_RS14880	COG1506	peptidase
LXN49_RS14880	COG4946	Tricorn protease homolog
LXN49_RS14885	COG0083	homoserine kinase activity
LXN49_RS14890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LXN49_RS14895	COG0460	homoserine dehydrogenase
LXN49_RS14900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LXN49_RS14905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LXN49_RS14910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LXN49_RS14915	COG0647	UMP catabolic process
LXN49_RS14920	COG2445	Protein of unknown function DUF86
LXN49_RS14925	COG4470	Protein conserved in bacteria
LXN49_RS14935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LXN49_RS14940	COG0739	heme binding
LXN49_RS14955	COG3377	Domain of unknown function (DUF1805)
LXN49_RS14960	COG0737	Belongs to the 5'-nucleotidase family
LXN49_RS14965	COG1801	Protein of unknown function DUF72
LXN49_RS14970	COG2508	Transcriptional regulator
LXN49_RS14975	COG2140	Oxalate decarboxylase
LXN49_RS14980	COG2814	Major facilitator Superfamily
LXN49_RS14985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LXN49_RS14990	COG2356	endonuclease I
LXN49_RS15000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LXN49_RS15005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LXN49_RS15010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LXN49_RS15025	COG5002	protein histidine kinase activity
LXN49_RS15025	COG0642	Histidine kinase
LXN49_RS15030	COG0745	RESPONSE REGULATOR receiver
LXN49_RS15035	COG2311	Membrane
LXN49_RS15045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LXN49_RS15055	COG1309	transcriptional regulator
LXN49_RS15060	COG0719	Fe-S assembly protein
LXN49_RS15065	COG0822	iron-sulfur transferase activity
LXN49_RS15070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LXN49_RS15075	COG0719	Fe-S assembly protein
LXN49_RS15080	COG0396	ATPase activity
LXN49_RS15085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LXN49_RS15090	COG1464	Belongs to the NlpA lipoprotein family
LXN49_RS15095	COG2011	ABC-type metal ion transport system permease component
LXN49_RS15100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LXN49_RS15110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXN49_RS15115	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LXN49_RS15125	COG0509	glycine decarboxylation via glycine cleavage system
LXN49_RS15130	COG1393	Belongs to the ArsC family
LXN49_RS15135	COG1960	acyl-CoA dehydrogenase activity
LXN49_RS15140	COG0183	Belongs to the thiolase family
LXN49_RS15145	COG1250	3-hydroxyacyl-CoA dehydrogenase
LXN49_RS15145	COG1024	Enoyl-CoA hydratase
LXN49_RS15160	COG5577	PFAM Coat F domain
LXN49_RS15170	COG1120	ATPase activity
LXN49_RS15180	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS15185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LXN49_RS15190	COG0745	RESPONSE REGULATOR receiver
LXN49_RS15195	COG2205	protein histidine kinase activity
LXN49_RS15195	COG2770	Histidine kinase
LXN49_RS15205	COG1309	transcriptional regulator
LXN49_RS15215	COG0114	fumarate hydratase activity
LXN49_RS15225	COG0697	spore germination
LXN49_RS15230	COG0814	amino acid
LXN49_RS15245	COG2197	response regulator
LXN49_RS15250	COG4585	Histidine kinase
LXN49_RS15255	COG4758	membrane
LXN49_RS15265	COG1842	Phage shock protein A
LXN49_RS15270	COG4758	membrane
LXN49_RS15275	COG2096	Adenosyltransferase
LXN49_RS15280	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS15285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LXN49_RS15295	COG2204	response regulator
LXN49_RS15310	COG1454	alcohol dehydrogenase
LXN49_RS15315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LXN49_RS15325	COG1120	ATPase activity
LXN49_RS15330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LXN49_RS15335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LXN49_RS15345	COG2721	sulfolactate sulfo-lyase activity
LXN49_RS15350	COG0246	Mannitol dehydrogenase
LXN49_RS15355	COG1609	Transcriptional regulator
LXN49_RS15360	COG1904	glucuronate isomerase
LXN49_RS15365	COG2205	protein histidine kinase activity
LXN49_RS15370	COG0745	RESPONSE REGULATOR receiver
LXN49_RS15375	COG1120	ATPase activity
LXN49_RS15380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LXN49_RS15385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LXN49_RS15390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LXN49_RS15395	COG0531	amino acid
LXN49_RS15410	COG1988	membrane-bound metal-dependent
LXN49_RS15415	COG1368	sulfuric ester hydrolase activity
LXN49_RS15420	COG0725	ABC transporter, periplasmic molybdate-binding protein
LXN49_RS15425	COG4149	molybdate abc transporter
LXN49_RS15430	COG0656	L-ascorbic acid biosynthetic process
LXN49_RS15435	COG1940	carbohydrate kinase activity
LXN49_RS15440	COG0025	NhaP-type Na H and K H
LXN49_RS15445	COG2860	membrane
LXN49_RS15450	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LXN49_RS15455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LXN49_RS15460	COG2217	Heavy metal translocating P-type atpase
LXN49_RS15465	COG1121	(ABC) transporter
LXN49_RS15470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LXN49_RS15475	COG0803	Belongs to the bacterial solute-binding protein 9 family
LXN49_RS15485	COG3226	Transcriptional regulator
LXN49_RS15490	COG0784	Response regulator, receiver
LXN49_RS15495	COG4191	Histidine kinase
LXN49_RS15500	COG1027	Aspartate ammonia-lyase
LXN49_RS15510	COG2217	Heavy metal translocating P-type atpase
LXN49_RS15515	COG2608	mercury ion transmembrane transporter activity
LXN49_RS15520	COG1937	Protein conserved in bacteria
LXN49_RS15575	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LXN49_RS15580	COG0557	exoribonuclease II activity
LXN49_RS15585	COG1647	Serine aminopeptidase, S33
LXN49_RS15590	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LXN49_RS15595	COG2002	toxin-antitoxin pair type II binding
LXN49_RS15600	COG1476	TRANSCRIPTIONal
LXN49_RS15605	COG1396	sequence-specific DNA binding
LXN49_RS15610	COG1396	sequence-specific DNA binding
LXN49_RS15615	COG1733	regulation of RNA biosynthetic process
LXN49_RS15620	COG1174	glycine betaine transport
LXN49_RS15625	COG1732	Glycine betaine
LXN49_RS15630	COG1174	glycine betaine transport
LXN49_RS15635	COG1125	glycine betaine transport
LXN49_RS15635	COG0517	IMP dehydrogenase activity
LXN49_RS15640	COG1510	regulation of RNA biosynthetic process
LXN49_RS15645	COG2095	MarC family integral membrane protein
LXN49_RS15655	COG0456	acetyltransferase
LXN49_RS15675	COG1122	ATPase activity
LXN49_RS15685	COG0148	phosphopyruvate hydratase activity
LXN49_RS15690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LXN49_RS15695	COG0149	triose-phosphate isomerase activity
LXN49_RS15700	COG0126	phosphoglycerate kinase activity
LXN49_RS15705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LXN49_RS15710	COG2390	Transcriptional regulator
LXN49_RS15715	COG0833	amino acid
LXN49_RS15720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LXN49_RS15725	COG3829	transcription factor binding
LXN49_RS15730	COG2186	Transcriptional regulator
LXN49_RS15735	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LXN49_RS15745	COG0534	Mate efflux family protein
LXN49_RS15755	COG0444	Belongs to the ABC transporter superfamily
LXN49_RS15760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LXN49_RS15765	COG0601	transmembrane transport
LXN49_RS15770	COG0747	negative chemotaxis
LXN49_RS15775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LXN49_RS15780	COG0110	maltose O-acetyltransferase activity
LXN49_RS15785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LXN49_RS15790	COG2244	polysaccharide biosynthetic process
LXN49_RS15795	COG5039	Polysaccharide pyruvyl transferase
LXN49_RS15800	COG1216	Glycosyl transferase, family 2
LXN49_RS15810	COG0438	transferase activity, transferring glycosyl groups
LXN49_RS15815	COG1215	transferase activity, transferring glycosyl groups
LXN49_RS15820	COG0438	transferase activity, transferring glycosyl groups
LXN49_RS15825	COG1086	Polysaccharide biosynthesis protein
LXN49_RS15830	COG0489	protein tyrosine kinase activity
LXN49_RS15835	COG3944	biosynthesis protein
LXN49_RS15840	COG1396	sequence-specific DNA binding
LXN49_RS15850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LXN49_RS15855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LXN49_RS15860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LXN49_RS15865	COG0726	polysaccharide deacetylase
LXN49_RS15870	COG0488	(ABC) transporter
LXN49_RS15890	COG0601	transmembrane transport
LXN49_RS15895	COG0747	negative chemotaxis
LXN49_RS15900	COG1819	glycosyl
LXN49_RS15910	COG0740	serine-type endopeptidase activity
LXN49_RS15915	COG1611	Belongs to the LOG family
LXN49_RS15920	COG1694	Mazg nucleotide pyrophosphohydrolase
LXN49_RS15925	COG0659	secondary active sulfate transmembrane transporter activity
LXN49_RS15930	COG0288	reversible hydration of carbon dioxide
LXN49_RS15935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LXN49_RS15945	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LXN49_RS15950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS15955	COG1481	regulation of sporulation
LXN49_RS15960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LXN49_RS15965	COG1660	Displays ATPase and GTPase activities
LXN49_RS15970	COG1051	belongs to the nudix hydrolase family
LXN49_RS15975	COG0492	ferredoxin-NADP+ reductase activity
LXN49_RS15980	COG0791	NLP P60 protein
LXN49_RS15980	COG3883	PFAM NLP P60 protein
LXN49_RS15985	COG0457	Tetratricopeptide repeat
LXN49_RS15990	COG0140	phosphoribosyl-ATP diphosphatase activity
LXN49_RS15990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LXN49_RS15995	COG0107	imidazoleglycerol-phosphate synthase activity
LXN49_RS16000	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LXN49_RS16005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LXN49_RS16010	COG0131	Imidazoleglycerol-phosphate dehydratase
LXN49_RS16015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LXN49_RS16020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LXN49_RS16025	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LXN49_RS16030	COG4990	cell redox homeostasis
LXN49_RS16040	COG2910	NAD(P)H-binding
LXN49_RS16045	COG1959	2 iron, 2 sulfur cluster binding
LXN49_RS16050	COG0110	maltose O-acetyltransferase activity
LXN49_RS16055	COG0546	phosphoglycolate phosphatase activity
LXN49_RS16060	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LXN49_RS16070	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LXN49_RS16075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LXN49_RS16080	COG0363	glucosamine-6-phosphate deaminase activity
LXN49_RS16085	COG2188	Transcriptional regulator
LXN49_RS16090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LXN49_RS16095	COG1950	PFAM Membrane protein of
LXN49_RS16100	COG1983	PspC domain protein
LXN49_RS16105	COG3595	metallopeptidase activity
LXN49_RS16120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LXN49_RS16130	COG4897	Protein conserved in bacteria
LXN49_RS16135	COG0574	Belongs to the PEP-utilizing enzyme family
LXN49_RS16135	COG3848	Pyruvate phosphate dikinase
LXN49_RS16140	COG1309	transcriptional regulator
LXN49_RS16145	COG2814	Major facilitator Superfamily
LXN49_RS16155	COG0745	RESPONSE REGULATOR receiver
LXN49_RS16160	COG5002	protein histidine kinase activity
LXN49_RS16165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LXN49_RS16170	COG0463	Glycosyl transferase, family 2
LXN49_RS16175	COG1113	amino acid transport
LXN49_RS16180	COG0778	Nitroreductase
LXN49_RS16185	COG1733	regulation of RNA biosynthetic process
LXN49_RS16190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LXN49_RS16200	COG3409	Peptidoglycan-binding domain 1 protein
LXN49_RS16200	COG0793	Belongs to the peptidase S41A family
LXN49_RS16205	COG0730	response to heat
LXN49_RS16210	COG0791	NLP P60 protein
LXN49_RS16210	COG3883	PFAM NLP P60 protein
LXN49_RS16215	COG2177	Part of the ABC transporter FtsEX involved in
LXN49_RS16220	COG2884	Cell division ATP-binding protein ftsE
LXN49_RS16225	COG2010	Cytochrome c
LXN49_RS16230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LXN49_RS16250	COG0653	protein targeting
LXN49_RS16255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LXN49_RS16260	COG0840	transmembrane signaling receptor activity
LXN49_RS16275	COG1516	flagellar protein fliS
LXN49_RS16280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LXN49_RS16285	COG1334	flagellar protein FlaG
LXN49_RS16290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LXN49_RS16295	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
LXN49_RS16305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LXN49_RS16310	COG1256	bacterial-type flagellum assembly
LXN49_RS16310	COG4786	Flagellar basal body rod
LXN49_RS16315	COG3418	PFAM FlgN family protein
LXN49_RS16330	COG1040	competence protein
LXN49_RS16340	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LXN49_RS16345	COG1307	EDD domain protein, DegV family
LXN49_RS16350	COG2197	response regulator
LXN49_RS16355	COG4585	Histidine kinase
LXN49_RS16360	COG1739	Uncharacterized protein family UPF0029
LXN49_RS16365	COG1316	TRANSCRIPTIONal
LXN49_RS16370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LXN49_RS16375	COG0438	transferase activity, transferring glycosyl groups
LXN49_RS16380	COG1215	transferase activity, transferring glycosyl groups
LXN49_RS16385	COG3206	protein involved in exopolysaccharide biosynthesis
LXN49_RS16390	COG3307	-O-antigen
LXN49_RS16395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LXN49_RS16400	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LXN49_RS16405	COG0297	glycogen (starch) synthase activity
LXN49_RS16405	COG0438	transferase activity, transferring glycosyl groups
LXN49_RS16410	COG2244	polysaccharide biosynthetic process
LXN49_RS16425	COG0860	N-Acetylmuramoyl-L-alanine amidase
LXN49_RS16425	COG2247	cell wall binding repeat
LXN49_RS16430	COG0860	N-Acetylmuramoyl-L-alanine amidase
LXN49_RS16430	COG2247	cell wall binding repeat
LXN49_RS16435	COG2247	cell wall binding repeat
LXN49_RS16435	COG2385	sporulation resulting in formation of a cellular spore
LXN49_RS16445	COG1316	TRANSCRIPTIONal
LXN49_RS16450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LXN49_RS16455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LXN49_RS16460	COG1134	teichoic acid transport
LXN49_RS16465	COG1682	transport, permease protein
LXN49_RS16475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LXN49_RS16485	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LXN49_RS16490	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LXN49_RS16495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LXN49_RS16500	COG4193	domain, Protein
LXN49_RS16505	COG1482	cell wall glycoprotein biosynthetic process
LXN49_RS16515	COG1175	transmembrane transport
LXN49_RS16520	COG1653	transport
LXN49_RS16525	COG2201	protein-glutamate methylesterase activity
LXN49_RS16530	COG2972	Histidine kinase
LXN49_RS16540	COG0454	-acetyltransferase
LXN49_RS16545	COG0800	Aldolase
LXN49_RS16550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LXN49_RS16555	COG1609	Transcriptional regulator
LXN49_RS16560	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LXN49_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS16570	COG0697	spore germination
LXN49_RS16575	COG0814	amino acid
LXN49_RS16590	COG2814	Major facilitator Superfamily
LXN49_RS16595	COG1316	TRANSCRIPTIONal
LXN49_RS16600	COG0561	phosphatase activity
LXN49_RS16605	COG0791	NLP P60 protein
LXN49_RS16615	COG2843	Capsule synthesis protein
LXN49_RS16625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LXN49_RS16630	COG0697	spore germination
LXN49_RS16645	COG1609	Transcriptional regulator
LXN49_RS16650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LXN49_RS16655	COG1869	D-ribose catabolic process
LXN49_RS16660	COG1129	ABC transporter
LXN49_RS16665	COG1172	Belongs to the binding-protein-dependent transport system permease family
LXN49_RS16670	COG1879	ABC-type sugar transport system periplasmic component
LXN49_RS16675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LXN49_RS16680	COG0583	DNA-binding transcription factor activity
LXN49_RS16685	COG0028	Belongs to the TPP enzyme family
LXN49_RS16690	COG3527	Alpha-acetolactate decarboxylase
LXN49_RS16695	COG1522	sequence-specific DNA binding
LXN49_RS16700	COG2059	Chromate
LXN49_RS16705	COG2059	Chromate
LXN49_RS16710	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LXN49_RS16720	COG4715	Zinc finger, swim domain protein
LXN49_RS16725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LXN49_RS16730	COG1366	Belongs to the anti-sigma-factor antagonist family
LXN49_RS16730	COG2202	Pas domain
LXN49_RS16735	COG0561	phosphatase activity
LXN49_RS16750	COG1970	mechanosensitive ion channel activity
LXN49_RS16755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LXN49_RS16760	COG0457	Tetratricopeptide repeat
LXN49_RS16765	COG4786	Flagellar basal body rod
LXN49_RS16770	COG4786	Flagellar basal body rod
LXN49_RS16775	COG1077	Cell shape determining protein MreB Mrl
LXN49_RS16780	COG1609	Transcriptional regulator
LXN49_RS16785	COG1846	Transcriptional regulator
LXN49_RS16790	COG2814	Major facilitator Superfamily
LXN49_RS16795	COG0671	phosphoesterase, PA-phosphatase related
LXN49_RS16800	COG0477	Major facilitator Superfamily
LXN49_RS16805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXN49_RS16810	COG0765	amino acid transport
LXN49_RS16820	COG0004	ammonium transporteR
LXN49_RS16825	COG0347	Belongs to the P(II) protein family
LXN49_RS16830	COG0739	heme binding
LXN49_RS16835	COG1247	-acetyltransferase
LXN49_RS16850	COG0523	cobalamin synthesis protein
LXN49_RS16855	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LXN49_RS16860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LXN49_RS16865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LXN49_RS16870	COG2223	nitrite transmembrane transporter activity
LXN49_RS16875	COG0243	molybdopterin cofactor binding
LXN49_RS16880	COG2304	oxidoreductase activity
LXN49_RS16885	COG2304	oxidoreductase activity
LXN49_RS16890	COG2385	sporulation resulting in formation of a cellular spore
LXN49_RS16895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LXN49_RS16905	COG4836	Membrane
LXN49_RS16915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LXN49_RS16920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LXN49_RS16925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LXN49_RS16930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LXN49_RS16935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LXN49_RS16940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LXN49_RS16945	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LXN49_RS16950	COG0356	it plays a direct role in the translocation of protons across the membrane
LXN49_RS16960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LXN49_RS16965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LXN49_RS16970	COG4475	Protein of unknown function (DUF436)
LXN49_RS16975	COG0698	ribose 5-phosphate isomerase
LXN49_RS16980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LXN49_RS16985	COG1971	Probably functions as a manganese efflux pump
LXN49_RS16990	COG0009	L-threonylcarbamoyladenylate synthase
LXN49_RS16995	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LXN49_RS17010	COG2890	protein-(glutamine-N5) methyltransferase activity
LXN49_RS17015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LXN49_RS17020	COG0789	Transcriptional regulator
LXN49_RS17025	COG0679	Auxin Efflux Carrier
LXN49_RS17030	COG0281	malic enzyme
LXN49_RS17035	COG1435	thymidine kinase activity
LXN49_RS17040	COG0254	rRNA binding
LXN49_RS17045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LXN49_RS17050	COG1494	fructose-1,6-bisphosphatase
LXN49_RS17055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LXN49_RS17060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LXN49_RS17065	COG0191	fructose-bisphosphate aldolase activity
LXN49_RS17070	COG2204	response regulator
LXN49_RS17075	COG4821	SIS domain
LXN49_RS17080	COG0504	CTP synthase activity
LXN49_RS17085	COG3343	RNA polymerase activity
LXN49_RS17095	COG1960	acyl-CoA dehydrogenase activity
LXN49_RS17100	COG1960	acyl-CoA dehydrogenase activity
LXN49_RS17105	COG1250	3-hydroxyacyl-CoA dehydrogenase
LXN49_RS17110	COG0183	Belongs to the thiolase family
LXN49_RS17115	COG0247	lactate metabolic process
LXN49_RS17115	COG2181	nitrate reductase activity
LXN49_RS17120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LXN49_RS17125	COG4294	response to UV
LXN49_RS17140	COG1132	(ABC) transporter
LXN49_RS17145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LXN49_RS17150	COG1619	proteins homologs of microcin C7 resistance protein MccF
LXN49_RS17155	COG0018	arginyl-trna synthetase
LXN49_RS17160	COG4506	Protein conserved in bacteria
LXN49_RS17170	COG0010	Belongs to the arginase family
LXN49_RS17175	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LXN49_RS17180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LXN49_RS17190	COG1994	Peptidase M50
LXN49_RS17195	COG1942	4-Oxalocrotonate Tautomerase
LXN49_RS17205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXN49_RS17210	COG0583	DNA-binding transcription factor activity
LXN49_RS17215	COG0431	NADPH-dependent FMN reductase
LXN49_RS17220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXN49_RS17225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LXN49_RS17230	COG0454	-acetyltransferase
LXN49_RS17235	COG0765	amino acid transport
LXN49_RS17250	COG1126	abc transporter atp-binding protein
LXN49_RS17255	COG3465	dGTPase activity
LXN49_RS17260	COG1078	dGTPase activity
LXN49_RS17265	COG4844	belongs to the
LXN49_RS17345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LXN49_RS17355	COG0280	phosphate acetyltransferase
LXN49_RS17365	COG2814	Major facilitator Superfamily
LXN49_RS17370	COG1522	sequence-specific DNA binding
LXN49_RS17375	COG2814	Major facilitator Superfamily
LXN49_RS17380	COG0077	Prephenate dehydratase
LXN49_RS17390	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS17395	COG0151	Belongs to the GarS family
LXN49_RS17400	COG0436	Aminotransferase
LXN49_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS17410	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LXN49_RS17415	COG1091	dTDP-4-dehydrorhamnose reductase activity
LXN49_RS17420	COG1088	dTDP-glucose 4,6-dehydratase activity
LXN49_RS17425	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LXN49_RS17430	COG3980	spore coat polysaccharide biosynthesis protein
LXN49_RS17435	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
LXN49_RS17440	COG2089	acid synthase
LXN49_RS17445	COG0456	acetyltransferase
LXN49_RS17450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LXN49_RS17455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LXN49_RS17460	COG0463	Glycosyl transferase, family 2
LXN49_RS17480	COG2363	Small membrane protein
LXN49_RS17485	COG2233	PERMEase
LXN49_RS17495	COG1012	belongs to the aldehyde dehydrogenase family
LXN49_RS17500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LXN49_RS17505	COG1216	Glycosyl transferase, family 2
LXN49_RS17515	COG0351	phosphomethylpyrimidine kinase
LXN49_RS17530	COG0457	Tetratricopeptide repeat
LXN49_RS17550	COG1621	beta-fructofuranosidase activity
LXN49_RS17555	COG1263	PTS System
LXN49_RS17555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS17560	COG3711	transcriptional antiterminator
LXN49_RS17570	COG1404	Belongs to the peptidase S8 family
LXN49_RS17575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LXN49_RS17580	COG0778	Nitroreductase
LXN49_RS17585	COG0772	Belongs to the SEDS family
LXN49_RS17595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LXN49_RS17600	COG1845	cytochrome c oxidase, subunit III
LXN49_RS17605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LXN49_RS17610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LXN49_RS17620	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LXN49_RS17625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LXN49_RS17630	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LXN49_RS17645	COG2246	polysaccharide biosynthetic process
LXN49_RS17665	COG3162	membrane
LXN49_RS17670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LXN49_RS17685	COG0352	thiamine-phosphate diphosphorylase activity
LXN49_RS17690	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LXN49_RS17695	COG0583	DNA-binding transcription factor activity
LXN49_RS17700	COG1380	Effector of murein hydrolase LrgA
LXN49_RS17705	COG1346	cytolysis
LXN49_RS17710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LXN49_RS17715	COG0346	lactoylglutathione lyase activity
LXN49_RS17725	COG0765	amino acid transport
LXN49_RS17730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LXN49_RS17735	COG0457	Tetratricopeptide repeat
LXN49_RS17745	COG2357	RelA SpoT domain protein
LXN49_RS17750	COG1172	Belongs to the binding-protein-dependent transport system permease family
LXN49_RS17755	COG1129	ABC transporter
LXN49_RS17765	COG3420	alginic acid biosynthetic process
LXN49_RS17770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LXN49_RS17780	COG1486	melibiose metabolic process
LXN49_RS17785	COG1447	Phosphotransferase system cellobiose-specific component IIA
LXN49_RS17790	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LXN49_RS17795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LXN49_RS17800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS17800	COG3711	transcriptional antiterminator
LXN49_RS17820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LXN49_RS17835	COG1595	DNA-templated transcription, initiation
LXN49_RS17845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LXN49_RS17850	COG4988	ABC transporter
LXN49_RS17855	COG1294	oxidase, subunit
LXN49_RS17860	COG1271	oxidase subunit
LXN49_RS17885	COG4509	Sortase family
LXN49_RS17910	COG5386	Cell surface protein
LXN49_RS17915	COG5386	Cell surface protein
LXN49_RS17920	COG1733	regulation of RNA biosynthetic process
LXN49_RS17925	COG2514	catechol 2,3-dioxygenase activity
LXN49_RS17930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LXN49_RS17930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LXN49_RS17935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LXN49_RS17935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LXN49_RS17945	COG0726	polysaccharide deacetylase
LXN49_RS17950	COG1447	Phosphotransferase system cellobiose-specific component IIA
LXN49_RS17955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LXN49_RS17960	COG2723	6-phospho-beta-galactosidase activity
LXN49_RS17965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LXN49_RS17970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LXN49_RS17970	COG3711	transcriptional antiterminator
LXN49_RS17995	COG1757	Na H antiporter
LXN49_RS18000	COG1027	Aspartate ammonia-lyase
LXN49_RS18005	COG0252	asparaginase activity
LXN49_RS18010	COG1396	sequence-specific DNA binding
LXN49_RS18035	COG4842	Belongs to the WXG100 family
LXN49_RS18040	COG2195	Cleaves the N-terminal amino acid of tripeptides
LXN49_RS18055	COG1737	Transcriptional regulator
LXN49_RS18060	COG2084	Dehydrogenase
LXN49_RS18070	COG2610	gluconate transmembrane transporter activity
LXN49_RS18075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LXN49_RS18085	COG2723	6-phospho-beta-galactosidase activity
LXN49_RS18090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS18090	COG2190	(PTS) system
LXN49_RS18090	COG1263	PTS System
LXN49_RS18095	COG3711	transcriptional antiterminator
LXN49_RS18100	COG3878	Protein conserved in bacteria
LXN49_RS18110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LXN49_RS18115	COG1122	ATPase activity
LXN49_RS18120	COG4721	ABC-type cobalt transport system, permease component
LXN49_RS18125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LXN49_RS18160	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LXN49_RS18165	COG0778	Nitroreductase
LXN49_RS18175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LXN49_RS18180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LXN49_RS18185	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LXN49_RS18190	COG2390	Transcriptional regulator
LXN49_RS18200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LXN49_RS18200	COG2755	lipolytic protein G-D-S-L family
LXN49_RS18220	COG0561	phosphatase activity
LXN49_RS18225	COG0789	Transcriptional regulator
LXN49_RS18230	COG0673	inositol 2-dehydrogenase activity
LXN49_RS18235	COG0840	transmembrane signaling receptor activity
LXN49_RS18240	COG1113	amino acid transport
LXN49_RS18245	COG4335	DNA alkylation repair
LXN49_RS18255	COG1070	Carbohydrate kinase
LXN49_RS18260	COG1737	Transcriptional regulator
LXN49_RS18290	COG0583	DNA-binding transcription factor activity
LXN49_RS18295	COG1609	Transcriptional regulator
LXN49_RS18300	COG2182	Extracellular solute-binding protein
LXN49_RS18305	COG1175	transmembrane transport
LXN49_RS18310	COG3833	ABC-type maltose transport systems, permease component
LXN49_RS18320	COG1874	Beta-galactosidase
LXN49_RS18325	COG2851	Citrate transporter
LXN49_RS18335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LXN49_RS18340	COG1131	(ABC) transporter
LXN49_RS18345	COG2824	Alkylphosphonate utilization operon protein PhnA
LXN49_RS18350	COG1929	Belongs to the glycerate kinase type-1 family
LXN49_RS18355	COG2610	gluconate transmembrane transporter activity
LXN49_RS18360	COG3835	regulator
LXN49_RS18365	COG1309	transcriptional regulator
LXN49_RS18370	COG2814	Major facilitator Superfamily
LXN49_RS18380	COG1136	(ABC) transporter
LXN49_RS18380	COG0577	efflux transmembrane transporter activity
LXN49_RS18390	COG0457	Tetratricopeptide repeat
LXN49_RS18395	COG3711	transcriptional antiterminator
LXN49_RS18400	COG2723	6-phospho-beta-galactosidase activity
LXN49_RS18405	COG2190	(PTS) system
LXN49_RS18405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LXN49_RS18405	COG1263	PTS System
LXN49_RS18440	COG1113	amino acid transport
LXN49_RS18445	COG1609	Transcriptional regulator
LXN49_RS18450	COG2814	Major facilitator Superfamily
LXN49_RS18460	COG2814	Major facilitator Superfamily
LXN49_RS18490	COG5444	nuclease activity
LXN49_RS18505	COG2723	6-phospho-beta-galactosidase activity
LXN49_RS18515	COG2188	Transcriptional regulator
LXN49_RS18530	COG0384	phenazine biosynthesis protein PhzF
LXN49_RS18535	COG0583	DNA-binding transcription factor activity
LXN49_RS18555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LXN49_RS18565	COG2814	Major facilitator Superfamily
LXN49_RS18570	COG0640	Transcriptional regulator
LXN49_RS18600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LXN49_RS18610	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LXN49_RS18620	COG4720	Psort location CytoplasmicMembrane, score
LXN49_RS18640	COG0456	acetyltransferase
LXN49_RS18645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LXN49_RS18650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LXN49_RS18655	COG4853	Protein conserved in bacteria
LXN49_RS18660	COG4863	YycH protein
LXN49_RS18665	COG5002	protein histidine kinase activity
LXN49_RS18670	COG0745	RESPONSE REGULATOR receiver
LXN49_RS18695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LXN49_RS18705	COG2311	Membrane
LXN49_RS18710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LXN49_RS18720	COG2124	cytochrome p450
LXN49_RS18725	COG0346	lactoylglutathione lyase activity
LXN49_RS18730	COG0305	Participates in initiation and elongation during chromosome replication
LXN49_RS18750	COG2819	hydrolase of the alpha beta superfamily
LXN49_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
LXN49_RS18760	COG1169	isochorismate synthase
LXN49_RS18765	COG1021	2,3-dihydroxybenzoate-AMP ligase
LXN49_RS18770	COG1535	isochorismatase
LXN49_RS18770	COG3433	isochorismatase activity
LXN49_RS18775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LXN49_RS18780	COG3251	PFAM MbtH domain protein
LXN49_RS18785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LXN49_RS18785	COG2207	Transcriptional regulator
LXN49_RS18790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LXN49_RS18795	COG2819	hydrolase of the alpha beta superfamily
LXN49_RS18800	COG3093	addiction module antidote protein HigA
LXN49_RS18805	COG2807	transmembrane transport
LXN49_RS18810	COG0359	binds to the 23S rRNA
LXN49_RS18815	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LXN49_RS18820	COG4241	membrane
LXN49_RS18825	COG1227	inorganic diphosphatase activity
LXN49_RS18835	COG1595	DNA-templated transcription, initiation
LXN49_RS18845	COG0753	catalase activity
LXN49_RS18850	COG0655	NAD(P)H dehydrogenase (quinone) activity
LXN49_RS18855	COG0400	carboxylic ester hydrolase activity
LXN49_RS18860	COG0346	lactoylglutathione lyase activity
LXN49_RS18865	COG1174	glycine betaine transport
LXN49_RS18870	COG0517	IMP dehydrogenase activity
LXN49_RS18870	COG1125	glycine betaine transport
LXN49_RS18875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LXN49_RS18880	COG0629	single-stranded DNA binding
LXN49_RS18885	COG0360	Binds together with S18 to 16S ribosomal RNA
LXN49_RS18890	COG0012	GTP binding
LXN49_RS18895	COG4481	Protein conserved in bacteria
LXN49_RS18910	COG3949	Membrane
LXN49_RS18920	COG1475	DNA binding
LXN49_RS18925	COG1192	Involved in chromosome partitioning
LXN49_RS18930	COG1475	DNA binding
LXN49_RS18935	COG0357	Ribosomal RNA small subunit methyltransferase G
LXN49_RS18940	COG0445	tRNA wobble uridine modification
LXN49_RS18945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LXN49_RS18950	COG1847	R3H domain protein
LXN49_RS18955	COG0706	membrane insertase activity
LXN49_RS18960	COG0594	ribonuclease P activity
LXN49_RS18970	COG1469	GTP cyclohydrolase I activity