locus-tag	class	description
UP17_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UP17_RS00010	COG0592	DNA-directed DNA polymerase activity
UP17_RS00015	COG2501	S4 domain
UP17_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
UP17_RS00030	COG0187	DNA topoisomerase II activity
UP17_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UP17_RS00070	COG0516	GMP reductase activity
UP17_RS00070	COG0517	IMP dehydrogenase activity
UP17_RS00090	COG1428	Deoxynucleoside kinase
UP17_RS00125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UP17_RS00170	COG1982	Orn Lys Arg decarboxylase major
UP17_RS00175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UP17_RS00180	COG3870	Protein conserved in bacteria
UP17_RS00185	COG1728	Protein conserved in bacteria
UP17_RS00190	COG0470	DNA polymerase III
UP17_RS00195	COG1774	PSP1 C-terminal conserved region
UP17_RS00200	COG4467	Involved in initiation control of chromosome replication
UP17_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
UP17_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UP17_RS00220	COG2002	toxin-antitoxin pair type II binding
UP17_RS00230	COG0084	hydrolase, TatD family'
UP17_RS00235	COG3583	domain protein
UP17_RS00235	COG3584	3D domain protein
UP17_RS00255	COG4466	Protein conserved in bacteria
UP17_RS00270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP17_RS00275	COG0251	oxidation-reduction process
UP17_RS00280	COG2088	sporulation resulting in formation of a cellular spore
UP17_RS00285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UP17_RS00295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UP17_RS00300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UP17_RS00315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UP17_RS00320	COG2002	toxin-antitoxin pair type II binding
UP17_RS00325	COG2244	polysaccharide biosynthetic process
UP17_RS00330	COG3956	TIGRFAM MazG family protein
UP17_RS00335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
UP17_RS00355	COG1098	S1 RNA binding domain
UP17_RS00370	COG2208	phosphoserine phosphatase activity
UP17_RS00375	COG2304	oxidoreductase activity
UP17_RS00380	COG0515	serine threonine protein kinase
UP17_RS00385	COG0037	tRNA processing
UP17_RS00390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
UP17_RS00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UP17_RS00400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
UP17_RS00405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
UP17_RS00410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP17_RS00415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP17_RS00420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UP17_RS00425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UP17_RS00430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UP17_RS00435	COG1396	sequence-specific DNA binding
UP17_RS00440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UP17_RS00445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UP17_RS00530	COG3880	PFAM UvrB UvrC protein
UP17_RS00535	COG3869	Catalyzes the specific phosphorylation of arginine residues in
UP17_RS00540	COG0542	response to heat
UP17_RS00545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
UP17_RS00555	COG4956	integral membrane protein (PIN domain superfamily)
UP17_RS00565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UP17_RS00570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UP17_RS00580	COG1045	serine acetyltransferase
UP17_RS00585	COG0215	cysteine-tRNA ligase activity
UP17_RS00595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UP17_RS00600	COG3688	RNA-binding protein containing a PIN domain
UP17_RS00610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UP17_RS00615	COG0250	Participates in transcription elongation, termination and antitermination
UP17_RS00620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UP17_RS00625	COG0081	regulation of translation
UP17_RS00635	COG0222	ribosome binding
UP17_RS00640	COG2813	Specifically methylates the guanine in position
UP17_RS00645	COG0085	RNA polymerase activity
UP17_RS00650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UP17_RS00655	COG1358	cellular component organization or biogenesis
UP17_RS00660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UP17_RS00665	COG0049	tRNA binding
UP17_RS00670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UP17_RS00675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UP17_RS00680	COG0051	transcription antitermination factor activity, RNA binding
UP17_RS00685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UP17_RS00690	COG0088	Forms part of the polypeptide exit tunnel
UP17_RS00700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UP17_RS00705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UP17_RS00710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UP17_RS00715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UP17_RS00720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UP17_RS00725	COG0255	Belongs to the universal ribosomal protein uL29 family
UP17_RS00730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UP17_RS00735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UP17_RS00740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UP17_RS00750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UP17_RS00755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UP17_RS00760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UP17_RS00765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UP17_RS00770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UP17_RS00775	COG1841	ribosomal large subunit assembly
UP17_RS00785	COG0201	protein transport
UP17_RS00790	COG0563	adenylate kinase activity
UP17_RS00795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UP17_RS00800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UP17_RS00805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UP17_RS00810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UP17_RS00815	COG0202	RNA polymerase activity
UP17_RS00820	COG0203	ribosomal protein L17
UP17_RS00825	COG1122	ATPase activity
UP17_RS00830	COG1122	ATPase activity
UP17_RS00835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
UP17_RS00845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UP17_RS00865	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP17_RS00870	COG0489	protein tyrosine kinase activity
UP17_RS00880	COG2194	sulfuric ester hydrolase activity
UP17_RS00885	COG0726	polysaccharide deacetylase
UP17_RS00965	COG1595	DNA-templated transcription, initiation
UP17_RS00970	COG5662	AntiSigma factor
UP17_RS00975	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
UP17_RS00980	COG4856	YbbR-like protein
UP17_RS00985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP17_RS00990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UP17_RS00995	COG5646	InterPro IPR014922
UP17_RS01010	COG5002	protein histidine kinase activity
UP17_RS01020	COG1132	(ABC) transporter
UP17_RS01040	COG1278	Cold shock
UP17_RS01060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UP17_RS01065	COG0493	'glutamate synthase
UP17_RS01070	COG0167	dihydroorotate dehydrogenase activity
UP17_RS01090	COG3835	regulator
UP17_RS01095	COG1597	lipid kinase activity
UP17_RS01100	COG0025	NhaP-type Na H and K H
UP17_RS01110	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
UP17_RS01120	COG3842	ATPase activity
UP17_RS01125	COG1176	ABC-type spermidine putrescine transport system, permease component I
UP17_RS01140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP17_RS01160	COG4821	SIS domain
UP17_RS01165	COG2188	Transcriptional regulator
UP17_RS01170	COG0363	glucosamine-6-phosphate deaminase activity
UP17_RS01175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UP17_RS01180	COG2190	(PTS) system
UP17_RS01180	COG1263	PTS System
UP17_RS01180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_RS01185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UP17_RS01200	COG2814	Major facilitator Superfamily
UP17_RS01205	COG1846	Transcriptional regulator
UP17_RS01210	COG2822	iron ion transport
UP17_RS01215	COG2837	iron assimilation
UP17_RS01220	COG0672	)-iron permease
UP17_RS01230	COG0789	Transcriptional regulator
UP17_RS01235	COG1253	flavin adenine dinucleotide binding
UP17_RS01240	COG2205	protein histidine kinase activity
UP17_RS01240	COG2198	Histidine kinase
UP17_RS01240	COG0784	Response regulator, receiver
UP17_RS01245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UP17_RS01250	COG2208	phosphoserine phosphatase activity
UP17_RS01290	COG4974	Belongs to the 'phage' integrase family
UP17_RS01295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UP17_RS01305	COG1597	lipid kinase activity
UP17_RS01330	COG1181	Belongs to the D-alanine--D-alanine ligase family
UP17_RS01335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UP17_RS01345	COG0513	Belongs to the DEAD box helicase family
UP17_RS01350	COG3402	PFAM membrane-flanked domain
UP17_RS01355	COG3428	Bacterial PH domain
UP17_RS01360	COG0705	Rhomboid family
UP17_RS01365	COG0736	holo-[acyl-carrier-protein] synthase activity
UP17_RS01370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UP17_RS01380	COG0864	Transcriptional regulator
UP17_RS01385	COG2337	Toxic component of a toxin-antitoxin (TA) module
UP17_RS01390	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_RS01395	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_RS01400	COG2172	sigma factor antagonist activity
UP17_RS01405	COG2208	phosphoserine phosphatase activity
UP17_RS01410	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_RS01415	COG2172	sigma factor antagonist activity
UP17_RS01420	COG1191	sigma factor activity
UP17_RS01425	COG2208	phosphoserine phosphatase activity
UP17_RS01430	COG2183	response to ionizing radiation
UP17_RS01515	COG0802	atpase or kinase
UP17_RS01520	COG1214	PFAM Peptidase M22, glycoprotease
UP17_RS01525	COG0456	acetyltransferase
UP17_RS01535	COG0488	(ABC) transporter
UP17_RS01540	COG0315	cyclic pyranopterin monophosphate synthase activity
UP17_RS01545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
UP17_RS01555	COG1266	CAAX protease self-immunity
UP17_RS01565	COG0459	protein refolding
UP17_RS01575	COG2205	protein histidine kinase activity
UP17_RS01580	COG2198	Histidine kinase
UP17_RS01580	COG0784	Response regulator, receiver
UP17_RS01580	COG2205	protein histidine kinase activity
UP17_RS01585	COG3104	oligopeptide transport
UP17_RS01600	COG1070	Carbohydrate kinase
UP17_RS01610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UP17_RS01630	COG0772	Belongs to the SEDS family
UP17_RS01640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP17_RS01640	COG4499	WXG100 protein secretion system (Wss), protein YukC
UP17_RS01655	COG2318	DinB family
UP17_RS01685	COG2964	Protein conserved in bacteria
UP17_RS01690	COG0251	oxidation-reduction process
UP17_RS01695	COG2271	Major facilitator Superfamily
UP17_RS01705	COG2385	sporulation resulting in formation of a cellular spore
UP17_RS01705	COG2247	cell wall binding repeat
UP17_RS01730	COG0531	amino acid
UP17_RS01735	COG0697	spore germination
UP17_RS01740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UP17_RS01755	COG2986	histidine ammonia-lyase
UP17_RS01760	COG0833	amino acid
UP17_RS01765	COG0825	malonyl-CoA metabolic process
UP17_RS01770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UP17_RS01785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UP17_RS01790	COG1288	antiporter activity
UP17_RS01800	COG0517	IMP dehydrogenase activity
UP17_RS01800	COG4175	Glycine betaine
UP17_RS01820	COG1957	nucleoside hydrolase
UP17_RS01825	COG4842	Belongs to the WXG100 family
UP17_RS01830	COG5417	Belongs to the EsaB family
UP17_RS01835	COG4499	WXG100 protein secretion system (Wss), protein YukC
UP17_RS01840	COG1674	ftsk spoiiie
UP17_RS01845	COG1511	domain protein
UP17_RS01855	COG0714	Associated with various cellular activities
UP17_RS01860	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
UP17_RS01865	COG1305	Transglutaminase-like
UP17_RS01870	COG0519	Catalyzes the synthesis of GMP from XMP
UP17_RS01870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UP17_RS01875	COG2252	PERMEase
UP17_RS01880	COG3711	transcriptional antiterminator
UP17_RS01885	COG2190	(PTS) system
UP17_RS01885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_RS01885	COG1263	PTS System
UP17_RS01925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UP17_RS01950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UP17_RS01955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
UP17_RS01960	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UP17_RS01970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UP17_RS01975	COG0047	phosphoribosylformylglycinamidine synthase activity
UP17_RS01985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UP17_RS01990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UP17_RS01995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UP17_RS02005	COG0151	Belongs to the GarS family
UP17_RS02020	COG1470	cell adhesion involved in biofilm formation
UP17_RS02025	COG4496	protein, YerC YecD
UP17_RS02030	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
UP17_RS02035	COG0210	DNA helicase
UP17_RS02040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UP17_RS02045	COG4851	CamS sex pheromone cAM373 precursor
UP17_RS02050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UP17_RS02055	COG0154	amidase activity
UP17_RS02060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UP17_RS02070	COG1597	lipid kinase activity
UP17_RS02075	COG0456	acetyltransferase
UP17_RS02090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_RS02095	COG2323	membrane
UP17_RS02110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP17_RS02135	COG1129	ABC transporter
UP17_RS02145	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
UP17_RS02150	COG3853	Toxic anion resistance protein (TelA)
UP17_RS02160	COG0653	protein targeting
UP17_RS02165	COG1404	Belongs to the peptidase S8 family
UP17_RS02170	COG4549	nuclear export factor GLE1
UP17_RS02175	COG2372	response to copper ion
UP17_RS02175	COG1276	copper resistance
UP17_RS02180	COG5002	protein histidine kinase activity
UP17_RS02190	COG4708	membrane
UP17_RS02195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UP17_RS02215	COG2204	response regulator
UP17_RS02220	COG3852	Histidine kinase
UP17_RS02230	COG2234	aminopeptidase activity
UP17_RS02255	COG0577	efflux transmembrane transporter activity
UP17_RS02260	COG1136	(ABC) transporter
UP17_RS02270	COG2226	methyltransferase
UP17_RS02270	COG1073	alpha beta
UP17_RS02275	COG0156	8-amino-7-oxononanoate synthase activity
UP17_RS02280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_RS02290	COG1653	transport
UP17_RS02305	COG1609	Transcriptional regulator
UP17_RS02315	COG0673	inositol 2-dehydrogenase activity
UP17_RS02320	COG0673	inositol 2-dehydrogenase activity
UP17_RS02330	COG1187	pseudouridine synthase activity
UP17_RS02340	COG0667	Aldo Keto reductase
UP17_RS02345	COG1114	Component of the transport system for branched-chain amino acids
UP17_RS02360	COG1129	ABC transporter
UP17_RS02365	COG1172	Belongs to the binding-protein-dependent transport system permease family
UP17_RS02380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP17_RS02395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UP17_RS02405	COG1845	cytochrome c oxidase, subunit III
UP17_RS02430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UP17_RS02435	COG0527	aspartate kinase activity
UP17_RS02440	COG0778	Nitroreductase
UP17_RS02450	COG1132	(ABC) transporter
UP17_RS02455	COG1132	(ABC) transporter
UP17_RS02470	COG1966	Carbon starvation protein
UP17_RS02480	COG0004	ammonium transporteR
UP17_RS02485	COG0347	Belongs to the P(II) protein family
UP17_RS02495	COG3279	Response regulator of the LytR AlgR family
UP17_RS02500	COG0427	acetyl-CoA hydrolase
UP17_RS02505	COG0628	permease
UP17_RS02510	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS02515	COG1301	dicarboxylic acid transport
UP17_RS02520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UP17_RS02525	COG3584	3D domain protein
UP17_RS02525	COG1388	LysM domain
UP17_RS02530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_RS02535	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
UP17_RS02560	COG2027	D-alanyl-D-alanine carboxypeptidase
UP17_RS02565	COG0546	phosphoglycolate phosphatase activity
UP17_RS02575	COG0778	Nitroreductase
UP17_RS02585	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS02590	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS02595	COG0243	molybdopterin cofactor binding
UP17_RS02600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_RS02605	COG5002	protein histidine kinase activity
UP17_RS02610	COG0513	Belongs to the DEAD box helicase family
UP17_RS02620	COG0626	cystathionine gamma-synthase activity
UP17_RS02630	COG0307	riboflavin synthase, alpha
UP17_RS02635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP17_RS02635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP17_RS02645	COG2404	hydrolase activity, acting on ester bonds
UP17_RS02650	COG1295	ribonuclease BN
UP17_RS02660	COG0475	glutathione-regulated potassium exporter activity
UP17_RS02665	COG0490	domain, Protein
UP17_RS02670	COG0582	viral genome integration into host DNA
UP17_RS02675	COG1077	Cell shape determining protein MreB Mrl
UP17_RS02685	COG3180	Ammonia monooxygenase
UP17_RS02690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UP17_RS02695	COG1360	Flagellar Motor Protein
UP17_RS02700	COG0693	protein deglycase activity
UP17_RS02705	COG0024	Methionine aminopeptidase
UP17_RS02715	COG1763	Mo-molybdopterin cofactor biosynthetic process
UP17_RS02720	COG0303	'Molybdopterin
UP17_RS02725	COG4840	Belongs to the UPF0435 family
UP17_RS02735	COG1295	ribonuclease BN
UP17_RS02745	COG2217	Heavy metal translocating P-type atpase
UP17_RS02750	COG0477	Major facilitator Superfamily
UP17_RS02755	COG0387	Pfam Sodium calcium exchanger
UP17_RS02765	COG0535	radical SAM domain protein
UP17_RS02790	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
UP17_RS02795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UP17_RS02800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UP17_RS02805	COG4807	Protein conserved in bacteria
UP17_RS02815	COG0156	8-amino-7-oxononanoate synthase activity
UP17_RS02825	COG1113	amino acid transport
UP17_RS02835	COG1072	(Pantothenic acid kinase))
UP17_RS02865	COG1733	regulation of RNA biosynthetic process
UP17_RS02870	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP17_RS02895	COG1686	Belongs to the peptidase S11 family
UP17_RS02905	COG0579	oxidoreductase
UP17_RS02915	COG2801	Transposase and inactivated derivatives
UP17_RS02920	COG2832	Protein of unknown function (DUF454)
UP17_RS02925	COG2814	Major facilitator Superfamily
UP17_RS02980	COG3344	reverse transcriptase
UP17_RS02995	COG3344	reverse transcriptase
UP17_RS03010	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS03035	COG3344	reverse transcriptase
UP17_RS03060	COG1309	transcriptional regulator
UP17_RS03080	COG0640	Transcriptional regulator
UP17_RS03100	COG2801	Transposase and inactivated derivatives
UP17_RS03135	COG2801	Transposase and inactivated derivatives
UP17_RS03160	COG0662	Cupin 2, conserved barrel domain protein
UP17_RS03170	COG4221	oxidoreductase activity
UP17_RS03180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP17_RS03185	COG3344	reverse transcriptase
UP17_RS03190	COG2364	Membrane
UP17_RS03195	COG1846	Transcriptional regulator
UP17_RS03200	COG0456	acetyltransferase
UP17_RS03210	COG0737	Belongs to the 5'-nucleotidase family
UP17_RS03210	COG4085	toxin activity
UP17_RS03210	COG1525	nuclease
UP17_RS03215	COG0737	Belongs to the 5'-nucleotidase family
UP17_RS03220	COG3344	reverse transcriptase
UP17_RS03240	COG2207	Transcriptional regulator
UP17_RS03245	COG0477	Major facilitator Superfamily
UP17_RS03250	COG2986	histidine ammonia-lyase
UP17_RS03260	COG1280	lysine exporter protein (LysE YggA)
UP17_RS03280	COG4978	Transcriptional regulator
UP17_RS03280	COG0789	Transcriptional regulator
UP17_RS03285	COG1811	Na channel or pump
UP17_RS03290	COG0425	Belongs to the sulfur carrier protein TusA family
UP17_RS03290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_RS03295	COG0477	Major facilitator Superfamily
UP17_RS03300	COG2814	Major facilitator Superfamily
UP17_RS03310	COG4413	Urea transporter
UP17_RS03315	COG0831	urea catabolic process
UP17_RS03325	COG0804	urea catabolic process
UP17_RS03330	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
UP17_RS03335	COG0830	nickel cation binding
UP17_RS03340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
UP17_RS03345	COG0829	nickel cation binding
UP17_RS03355	COG1695	Transcriptional regulator
UP17_RS03370	COG1840	ABC-type Fe3 transport system, periplasmic component
UP17_RS03375	COG3842	ATPase activity
UP17_RS03385	COG0165	Argininosuccinate lyase
UP17_RS03400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_RS03410	COG1113	amino acid transport
UP17_RS03415	COG1113	amino acid transport
UP17_RS03420	COG0531	amino acid
UP17_RS03425	COG0277	FAD linked oxidase domain protein
UP17_RS03455	COG1131	(ABC) transporter
UP17_RS03460	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP17_RS03465	COG1131	(ABC) transporter
UP17_RS03525	COG3069	C4-dicarboxylate transmembrane transporter activity
UP17_RS03545	COG1136	(ABC) transporter
UP17_RS03550	COG0577	efflux transmembrane transporter activity
UP17_RS03560	COG2205	protein histidine kinase activity
UP17_RS03565	COG0745	RESPONSE REGULATOR receiver
UP17_RS03575	COG1126	abc transporter atp-binding protein
UP17_RS03580	COG0765	amino acid transport
UP17_RS03585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP17_RS03605	COG0436	Aminotransferase
UP17_RS03620	COG1388	LysM domain
UP17_RS03620	COG0791	NLP P60 protein
UP17_RS03635	COG1695	Transcriptional regulator
UP17_RS03650	COG2814	Major facilitator Superfamily
UP17_RS03670	COG2124	cytochrome p450
UP17_RS03675	COG0166	Belongs to the GPI family
UP17_RS03680	COG0628	permease
UP17_RS03690	COG0765	amino acid transport
UP17_RS03695	COG1126	abc transporter atp-binding protein
UP17_RS03705	COG0583	DNA-binding transcription factor activity
UP17_RS03725	COG1960	acyl-CoA dehydrogenase activity
UP17_RS03730	COG0183	Belongs to the thiolase family
UP17_RS03745	COG1090	epimerase
UP17_RS03770	COG1988	membrane-bound metal-dependent
UP17_RS03775	COG1194	a g-specific adenine glycosylase
UP17_RS03785	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS03800	COG3557	Belongs to the UPF0374 family
UP17_RS03805	COG1132	(ABC) transporter
UP17_RS03820	COG0655	NAD(P)H dehydrogenase (quinone) activity
UP17_RS03825	COG2814	Major facilitator Superfamily
UP17_RS03830	COG1566	PFAM secretion protein HlyD family protein
UP17_RS03840	COG4129	membrane
UP17_RS03845	COG0070	glutamate synthase
UP17_RS03845	COG0069	glutamate synthase activity
UP17_RS03845	COG0067	glutamate synthase
UP17_RS03850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UP17_RS03860	COG4555	ABC transporter
UP17_RS03875	COG1607	acyl-coa hydrolase
UP17_RS03890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UP17_RS03900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP17_RS03905	COG0735	belongs to the Fur family
UP17_RS04020	COG2066	Belongs to the glutaminase family
UP17_RS04025	COG2066	Belongs to the glutaminase family
UP17_RS04035	COG0582	viral genome integration into host DNA
UP17_RS04060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UP17_RS04065	COG2205	protein histidine kinase activity
UP17_RS04070	COG0584	glycerophosphoryl diester phosphodiesterase
UP17_RS04095	COG1011	Hydrolase
UP17_RS04100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UP17_RS04110	COG5577	PFAM Coat F domain
UP17_RS04115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UP17_RS04130	COG3546	catalase activity
UP17_RS04140	COG2162	N-hydroxyarylamine O-acetyltransferase activity
UP17_RS04155	COG1388	LysM domain
UP17_RS04215	COG0697	spore germination
UP17_RS04230	COG0531	amino acid
UP17_RS04235	COG0531	amino acid
UP17_RS04250	COG1595	DNA-templated transcription, initiation
UP17_RS04260	COG1011	Hydrolase
UP17_RS04265	COG0477	Major facilitator Superfamily
UP17_RS04275	COG2204	response regulator
UP17_RS04300	COG1309	transcriptional regulator
UP17_RS04305	COG0477	Major facilitator Superfamily
UP17_RS04310	COG1902	pentaerythritol trinitrate reductase activity
UP17_RS04320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_RS04335	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UP17_RS04345	COG0833	amino acid
UP17_RS04350	COG0251	oxidation-reduction process
UP17_RS04355	COG2515	1-aminocyclopropane-1-carboxylate deaminase
UP17_RS04365	COG2239	Acts as a magnesium transporter
UP17_RS04370	COG2130	NADP-dependent
UP17_RS04375	COG1289	transmembrane transporter activity
UP17_RS04390	COG3382	B3 4 domain protein
UP17_RS04395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UP17_RS04400	COG2323	membrane
UP17_RS04410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UP17_RS04415	COG0778	Nitroreductase
UP17_RS04425	COG0784	Response regulator, receiver
UP17_RS04430	COG4191	Histidine kinase
UP17_RS04440	COG0531	amino acid
UP17_RS04445	COG2766	serine protein kinase
UP17_RS04465	COG2807	transmembrane transport
UP17_RS04480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP17_RS04490	COG0463	Glycosyl transferase, family 2
UP17_RS04500	COG0531	amino acid
UP17_RS04525	COG0385	Bile acid
UP17_RS04540	COG0778	Nitroreductase
UP17_RS04560	COG3961	Belongs to the TPP enzyme family
UP17_RS04570	COG0791	NLP P60 protein
UP17_RS04570	COG1388	LysM domain
UP17_RS04575	COG3689	TIGRFAM TIGR03943 family protein
UP17_RS04580	COG0701	Predicted permease
UP17_RS04585	COG2094	Belongs to the DNA glycosylase MPG family
UP17_RS04590	COG0477	Major facilitator Superfamily
UP17_RS04595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP17_RS04600	COG0277	FAD linked oxidase domain protein
UP17_RS04605	COG0686	Belongs to the AlaDH PNT family
UP17_RS04610	COG2217	Heavy metal translocating P-type atpase
UP17_RS04615	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UP17_RS04615	COG2508	Transcriptional regulator
UP17_RS04620	COG0306	phosphate transporter
UP17_RS04625	COG1392	Phosphate transport regulator
UP17_RS04630	COG0306	phosphate transporter
UP17_RS04635	COG0656	L-ascorbic acid biosynthetic process
UP17_RS04640	COG2261	transglycosylase associated protein
UP17_RS04645	COG0564	pseudouridine synthase activity
UP17_RS04665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UP17_RS04665	COG3153	acetyltransferase
UP17_RS04670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP17_RS04675	COG0431	NADPH-dependent FMN reductase
UP17_RS04695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UP17_RS04705	COG1473	amidohydrolase
UP17_RS04715	COG4948	Mandelate Racemase Muconate Lactonizing
UP17_RS04720	COG3949	Membrane
UP17_RS04725	COG2719	SpoVR family
UP17_RS04730	COG0640	Transcriptional regulator
UP17_RS04735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UP17_RS04740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UP17_RS04750	COG2801	Transposase and inactivated derivatives
UP17_RS04765	COG0398	Pfam SNARE associated Golgi protein
UP17_RS04770	COG0745	RESPONSE REGULATOR receiver
UP17_RS04775	COG5002	protein histidine kinase activity
UP17_RS04795	COG1522	sequence-specific DNA binding
UP17_RS04800	COG2059	Chromate
UP17_RS04805	COG2059	Chromate
UP17_RS04810	COG0405	Gamma-glutamyltransferase
UP17_RS04815	COG0697	spore germination
UP17_RS04830	COG0531	amino acid
UP17_RS04845	COG2508	Transcriptional regulator
UP17_RS04850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_RS04855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
UP17_RS04860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UP17_RS04870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_RS04880	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
UP17_RS04885	COG0492	ferredoxin-NADP+ reductase activity
UP17_RS04895	COG3396	Phenylacetate-CoA oxygenase
UP17_RS04920	COG1024	Enoyl-CoA hydratase
UP17_RS04925	COG1024	Enoyl-CoA hydratase
UP17_RS04930	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS04935	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP17_RS04940	COG0183	Belongs to the thiolase family
UP17_RS04945	COG1024	Enoyl-CoA hydratase
UP17_RS04960	COG2070	2-Nitropropane dioxygenase
UP17_RS04965	COG0586	Pfam SNARE associated Golgi protein
UP17_RS04985	COG0745	RESPONSE REGULATOR receiver
UP17_RS04990	COG5002	protein histidine kinase activity
UP17_RS04995	COG1393	Belongs to the ArsC family
UP17_RS05015	COG1393	Belongs to the ArsC family
UP17_RS05020	COG4149	molybdate abc transporter
UP17_RS05035	COG1278	Cold shock
UP17_RS05040	COG0716	FMN binding
UP17_RS05045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP17_RS05050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP17_RS05055	COG1227	inorganic diphosphatase activity
UP17_RS05060	COG0659	secondary active sulfate transmembrane transporter activity
UP17_RS05075	COG2814	Major facilitator Superfamily
UP17_RS05080	COG2851	Citrate transporter
UP17_RS05090	COG1054	Belongs to the UPF0176 family
UP17_RS05100	COG0456	acetyltransferase
UP17_RS05110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_RS05125	COG0628	permease
UP17_RS05130	COG1253	flavin adenine dinucleotide binding
UP17_RS05135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_RS05145	COG0586	Pfam SNARE associated Golgi protein
UP17_RS05150	COG1253	flavin adenine dinucleotide binding
UP17_RS05155	COG3852	Histidine kinase
UP17_RS05160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UP17_RS05165	COG3859	Proton-coupled thiamine transporter YuaJ
UP17_RS05170	COG0589	response to stress
UP17_RS05175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP17_RS05185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UP17_RS05205	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_RS05220	COG1113	amino acid transport
UP17_RS05225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UP17_RS05230	COG1522	sequence-specific DNA binding
UP17_RS05240	COG1522	sequence-specific DNA binding
UP17_RS05250	COG0393	Putative heavy-metal-binding
UP17_RS05255	COG0753	catalase activity
UP17_RS05260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UP17_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS05290	COG0517	IMP dehydrogenase activity
UP17_RS05290	COG0516	GMP reductase activity
UP17_RS05295	COG0768	penicillin binding
UP17_RS05310	COG1132	(ABC) transporter
UP17_RS05315	COG1132	(ABC) transporter
UP17_RS05320	COG0254	rRNA binding
UP17_RS05325	COG0626	cystathionine gamma-synthase activity
UP17_RS05330	COG0626	cystathionine gamma-synthase activity
UP17_RS05335	COG0114	fumarate hydratase activity
UP17_RS05345	COG3842	ATPase activity
UP17_RS05350	COG2508	Transcriptional regulator
UP17_RS05360	COG1215	transferase activity, transferring glycosyl groups
UP17_RS05360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP17_RS05365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP17_RS05365	COG1215	transferase activity, transferring glycosyl groups
UP17_RS05385	COG0189	ligase activity
UP17_RS05390	COG0189	ligase activity
UP17_RS05395	COG0189	ligase activity
UP17_RS05410	COG3679	Belongs to the UPF0342 family
UP17_RS05415	COG0561	phosphatase activity
UP17_RS05445	COG1834	amidinotransferase
UP17_RS05450	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_RS05455	COG1024	Enoyl-CoA hydratase
UP17_RS05475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP17_RS05485	COG0420	3'-5' exonuclease activity
UP17_RS05490	COG4717	serine-type aminopeptidase activity
UP17_RS05500	COG1120	ATPase activity
UP17_RS05520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP17_RS05550	COG1846	Transcriptional regulator
UP17_RS05555	COG4980	gas vesicle protein
UP17_RS05575	COG0537	adenosine 5'-monophosphoramidase activity
UP17_RS05580	COG1131	(ABC) transporter
UP17_RS05585	COG4473	ABC transporter
UP17_RS05595	COG1473	amidohydrolase
UP17_RS05600	COG0671	phosphoesterase, PA-phosphatase related
UP17_RS05605	COG2329	Antibiotic biosynthesis monooxygenase
UP17_RS05610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UP17_RS05615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
UP17_RS05620	COG1309	transcriptional regulator
UP17_RS05625	COG1234	tRNA 3'-trailer cleavage
UP17_RS05630	COG0095	Lipoate-protein ligase
UP17_RS05635	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_RS05640	COG1418	mRNA catabolic process
UP17_RS05650	COG0501	Belongs to the peptidase M48B family
UP17_RS05655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_RS05665	COG4903	ComK protein
UP17_RS05675	COG0398	Pfam SNARE associated Golgi protein
UP17_RS05685	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
UP17_RS05690	COG1074	ATP-dependent DNA helicase activity
UP17_RS05740	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_RS05745	COG2271	Major facilitator Superfamily
UP17_RS05750	COG2311	Membrane
UP17_RS05765	COG0367	asparagine synthase
UP17_RS05775	COG2182	Extracellular solute-binding protein
UP17_RS05780	COG0366	Alpha amylase catalytic
UP17_RS05780	COG1874	Beta-galactosidase
UP17_RS05785	COG0366	Alpha amylase catalytic
UP17_RS05790	COG1609	Transcriptional regulator
UP17_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS05810	COG1307	EDD domain protein, DegV family
UP17_RS05815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_RS05825	COG0561	phosphatase activity
UP17_RS05830	COG1073	alpha beta
UP17_RS05835	COG2151	metal-sulfur cluster biosynthetic enzyme
UP17_RS05840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UP17_RS05845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UP17_RS05850	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UP17_RS05855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
UP17_RS05860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UP17_RS05870	COG0505	Belongs to the CarA family
UP17_RS05880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UP17_RS05895	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP17_RS05910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UP17_RS05925	COG2267	carboxylic ester hydrolase activity
UP17_RS05945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP17_RS05950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UP17_RS05955	COG5504	Zn-dependent protease
UP17_RS05965	COG0180	Tryptophanyl-tRNA synthetase
UP17_RS05980	COG0456	acetyltransferase
UP17_RS05990	COG1393	Belongs to the ArsC family
UP17_RS05995	COG4862	establishment of competence for transformation
UP17_RS06000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_RS06005	COG4469	Competence protein
UP17_RS06010	COG1164	Oligoendopeptidase f
UP17_RS06015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UP17_RS06020	COG2346	COG2346, Truncated hemoglobins
UP17_RS06025	COG0741	lytic transglycosylase activity
UP17_RS06030	COG4116	CYTH
UP17_RS06035	COG2357	RelA SpoT domain protein
UP17_RS06045	COG0564	pseudouridine synthase activity
UP17_RS06050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UP17_RS06055	COG2239	Acts as a magnesium transporter
UP17_RS06060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UP17_RS06110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP17_RS06130	COG0210	DNA helicase
UP17_RS06150	COG2153	protein acetylation
UP17_RS06155	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
UP17_RS06160	COG2382	esterase
UP17_RS06165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UP17_RS06185	COG0693	protein deglycase activity
UP17_RS06190	COG2323	membrane
UP17_RS06215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UP17_RS06220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UP17_RS06225	COG1960	acyl-CoA dehydrogenase activity
UP17_RS06240	COG5337	Spore coat protein CotH
UP17_RS06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_RS06260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP17_RS06265	COG2814	Major facilitator Superfamily
UP17_RS06275	COG0673	inositol 2-dehydrogenase activity
UP17_RS06285	COG1902	pentaerythritol trinitrate reductase activity
UP17_RS06290	COG2723	6-phospho-beta-galactosidase activity
UP17_RS06295	COG0659	secondary active sulfate transmembrane transporter activity
UP17_RS06300	COG0789	Transcriptional regulator
UP17_RS06305	COG2272	Belongs to the type-B carboxylesterase lipase family
UP17_RS06315	COG3844	kynureninase activity
UP17_RS06320	COG1113	amino acid transport
UP17_RS06325	COG3483	tryptophan 2,3-dioxygenase activity
UP17_RS06330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UP17_RS06335	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
UP17_RS06345	COG4208	sulfate ABC transporter
UP17_RS06355	COG3883	PFAM NLP P60 protein
UP17_RS06355	COG0791	NLP P60 protein
UP17_RS06375	COG2017	converts alpha-aldose to the beta-anomer
UP17_RS06380	COG0531	amino acid
UP17_RS06400	COG1278	Cold shock
UP17_RS06410	COG2309	aminopeptidase activity
UP17_RS06415	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS06420	COG0477	Major facilitator Superfamily
UP17_RS06430	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
UP17_RS06435	COG0351	phosphomethylpyrimidine kinase
UP17_RS06435	COG0352	thiamine-phosphate diphosphorylase activity
UP17_RS06445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UP17_RS06455	COG1247	-acetyltransferase
UP17_RS06465	COG2814	Major facilitator Superfamily
UP17_RS06475	COG1876	peptidase activity
UP17_RS06480	COG1607	acyl-coa hydrolase
UP17_RS06485	COG0670	Belongs to the BI1 family
UP17_RS06495	COG4608	Belongs to the ABC transporter superfamily
UP17_RS06500	COG0601	transmembrane transport
UP17_RS06505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP17_RS06520	COG1363	Peptidase, m42
UP17_RS06525	COG3871	stress protein (general stress protein 26)
UP17_RS06535	COG1181	Belongs to the D-alanine--D-alanine ligase family
UP17_RS06535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UP17_RS06540	COG1404	Belongs to the peptidase S8 family
UP17_RS06540	COG4412	M6 family metalloprotease domain protein
UP17_RS06555	COG0584	glycerophosphoryl diester phosphodiesterase
UP17_RS06565	COG1764	response to oxidative stress
UP17_RS06570	COG1725	Transcriptional regulator
UP17_RS06575	COG1131	(ABC) transporter
UP17_RS06590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
UP17_RS06600	COG3290	protein histidine kinase activity
UP17_RS06605	COG4565	transcriptional regulatory protein
UP17_RS06610	COG0281	malic enzyme
UP17_RS06615	COG0679	Auxin Efflux Carrier
UP17_RS06620	COG1757	Na H antiporter
UP17_RS06625	COG0772	Belongs to the SEDS family
UP17_RS06640	COG0861	Integral membrane protein TerC family
UP17_RS06645	COG1191	sigma factor activity
UP17_RS06660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UP17_RS06665	COG3852	Histidine kinase
UP17_RS06700	COG3594	Acyltransferase
UP17_RS06705	COG5002	protein histidine kinase activity
UP17_RS06720	COG2223	nitrite transmembrane transporter activity
UP17_RS06725	COG3852	Histidine kinase
UP17_RS06730	COG1846	Transcriptional regulator
UP17_RS06740	COG3949	Membrane
UP17_RS06760	COG1525	nuclease
UP17_RS06765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UP17_RS06770	COG0390	transport system, permease component
UP17_RS06775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_RS06780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UP17_RS06790	COG2084	Dehydrogenase
UP17_RS06800	COG0436	Aminotransferase
UP17_RS06805	COG0598	Magnesium transport protein CorA
UP17_RS06815	COG0835	chemotaxis
UP17_RS06815	COG0784	Response regulator, receiver
UP17_RS06830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UP17_RS06835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UP17_RS06840	COG1408	metallophosphoesterase
UP17_RS06845	COG0490	domain, Protein
UP17_RS06845	COG0471	metal ion transport
UP17_RS06850	COG2200	EAL domain
UP17_RS06875	COG4703	Protein of unknown function (DUF1797)
UP17_RS06880	COG0517	IMP dehydrogenase activity
UP17_RS06885	COG0477	Major facilitator Superfamily
UP17_RS06890	COG0583	DNA-binding transcription factor activity
UP17_RS06895	COG2171	N-acyltransferase activity
UP17_RS06900	COG1473	amidohydrolase
UP17_RS06905	COG0569	domain protein
UP17_RS06910	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP17_RS06915	COG5503	Protein of unknown function (DUF1447)
UP17_RS06920	COG0561	phosphatase activity
UP17_RS06930	COG0497	DNA recombination
UP17_RS06940	COG0022	dehydrogenase e1 component
UP17_RS06945	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_RS06970	COG1982	Orn Lys Arg decarboxylase major
UP17_RS06980	COG4476	Belongs to the UPF0223 family
UP17_RS06990	COG0512	Glutamine amidotransferase of anthranilate synthase
UP17_RS06990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UP17_RS06995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UP17_RS07030	COG0483	inositol monophosphate 1-phosphatase activity
UP17_RS07040	COG1217	gtp-binding protein TYPA
UP17_RS07060	COG4896	Protein conserved in bacteria
UP17_RS07070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UP17_RS07075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UP17_RS07080	COG4838	Belongs to the UPF0358 family
UP17_RS07085	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
UP17_RS07090	COG1612	heme a metabolic process
UP17_RS07095	COG0109	protoheme IX farnesyltransferase activity
UP17_RS07120	COG3336	cytochrome c oxidase
UP17_RS07135	COG2340	Cysteine-rich secretory protein family
UP17_RS07155	COG3679	Belongs to the UPF0342 family
UP17_RS07165	COG4471	UPF0298 protein
UP17_RS07175	COG0742	ribosomal rna small subunit methyltransferase
UP17_RS07180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UP17_RS07185	COG3314	Sporulation integral membrane protein YlbJ
UP17_RS07190	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP17_RS07195	COG3480	Lon protease (S16) C-terminal proteolytic domain
UP17_RS07200	COG2801	Transposase and inactivated derivatives
UP17_RS07205	COG1323	Belongs to the UPF0348 family
UP17_RS07210	COG1399	metal-binding, possibly nucleic acid-binding protein
UP17_RS07215	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UP17_RS07220	COG1024	Enoyl-CoA hydratase
UP17_RS07230	COG0454	-acetyltransferase
UP17_RS07235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UP17_RS07245	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
UP17_RS07250	COG2001	Belongs to the MraZ family
UP17_RS07260	COG4839	cell division protein FtsL
UP17_RS07265	COG0768	penicillin binding
UP17_RS07275	COG0768	penicillin binding
UP17_RS07285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UP17_RS07290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UP17_RS07295	COG0772	Belongs to the SEDS family
UP17_RS07300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UP17_RS07305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
UP17_RS07310	COG3879	Bacterial protein of unknown function (DUF881)
UP17_RS07315	COG3879	Bacterial protein of unknown function (DUF881)
UP17_RS07320	COG3856	small basic protein
UP17_RS07325	COG0849	cell division
UP17_RS07330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UP17_RS07340	COG1191	sigma factor activity
UP17_RS07345	COG1191	sigma factor activity
UP17_RS07350	COG1873	PFAM PRC-barrel domain
UP17_RS07355	COG1496	oxidoreductase activity
UP17_RS07360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UP17_RS07365	COG1799	cell septum assembly
UP17_RS07370	COG0762	integral membrane protein
UP17_RS07375	COG2302	S4 RNA-binding domain
UP17_RS07380	COG3599	regulation of cell shape
UP17_RS07390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UP17_RS07395	COG0564	pseudouridine synthase activity
UP17_RS07400	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
UP17_RS07410	COG0540	Belongs to the ATCase OTCase family
UP17_RS07415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UP17_RS07420	COG0505	Belongs to the CarA family
UP17_RS07425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UP17_RS07435	COG0167	dihydroorotate dehydrogenase activity
UP17_RS07440	COG0284	orotidine-5'-phosphate decarboxylase activity
UP17_RS07445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UP17_RS07455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UP17_RS07460	COG1561	YicC-like family, N-terminal region
UP17_RS07470	COG0194	GDP metabolic process
UP17_RS07480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UP17_RS07485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UP17_RS07500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UP17_RS07500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
UP17_RS07505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UP17_RS07510	COG0631	protein serine/threonine phosphatase activity
UP17_RS07515	COG0515	serine threonine protein kinase
UP17_RS07515	COG2815	serine threonine protein kinase
UP17_RS07525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UP17_RS07530	COG1564	THIamine pyrophosphokinase
UP17_RS07540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UP17_RS07545	COG1302	Protein conserved in bacteria
UP17_RS07550	COG1461	Dihydroxyacetone kinase
UP17_RS07555	COG1760	l-serine dehydratase
UP17_RS07560	COG1760	l-serine dehydratase
UP17_RS07565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UP17_RS07570	COG1349	DNA-binding transcription factor activity
UP17_RS07580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UP17_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS07595	COG0571	ribonuclease III activity
UP17_RS07600	COG1196	nuclear chromosome segregation
UP17_RS07605	COG0552	protein localization to endoplasmic reticulum
UP17_RS07615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UP17_RS07620	COG0228	four-way junction DNA binding
UP17_RS07625	COG1837	Belongs to the UPF0109 family
UP17_RS07635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UP17_RS07640	COG0336	Belongs to the RNA methyltransferase TrmD family
UP17_RS07645	COG0335	large ribosomal subunit rRNA binding
UP17_RS07655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
UP17_RS07660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UP17_RS07685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP17_RS07690	COG0045	succinate-CoA ligase (ADP-forming) activity
UP17_RS07695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UP17_RS07700	COG0758	DNA mediated transformation
UP17_RS07705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UP17_RS07710	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
UP17_RS07715	COG4974	Belongs to the 'phage' integrase family
UP17_RS07725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
UP17_RS07730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UP17_RS07735	COG1815	bacterial-type flagellum-dependent cell motility
UP17_RS07740	COG1558	bacterial-type flagellum-dependent cell motility
UP17_RS07745	COG1677	Flagellar hook-basal body complex protein FliE
UP17_RS07750	COG1766	The M ring may be actively involved in energy transduction
UP17_RS07755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP17_RS07760	COG1317	bacterial-type flagellum organization
UP17_RS07765	COG1157	protein secretion by the type III secretion system
UP17_RS07770	COG2882	bacterial-type flagellum organization
UP17_RS07785	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UP17_RS07800	COG1582	Flagellar protein (FlbD)
UP17_RS07810	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP17_RS07815	COG1776	CheC inhibitor of MCP methylation
UP17_RS07815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP17_RS07820	COG2201	protein-glutamate methylesterase activity
UP17_RS07825	COG3190	flagellar
UP17_RS07830	COG1338	Plays a role in the flagellum-specific transport system
UP17_RS07835	COG1987	bacterial-type flagellum assembly
UP17_RS07840	COG1684	flagellar biosynthetic protein fliR
UP17_RS07845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP17_RS07850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP17_RS07855	COG1419	protein localization to endoplasmic reticulum
UP17_RS07860	COG0455	bacterial-type flagellum organization
UP17_RS07865	COG2201	protein-glutamate methylesterase activity
UP17_RS07870	COG0643	Histidine kinase
UP17_RS07870	COG2198	Histidine kinase
UP17_RS07875	COG0835	chemotaxis
UP17_RS07880	COG1776	CheC inhibitor of MCP methylation
UP17_RS07885	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
UP17_RS07890	COG1191	sigma factor activity
UP17_RS07915	COG0528	UMP kinase activity
UP17_RS07930	COG4589	Belongs to the CDS family
UP17_RS07935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UP17_RS07940	COG0750	zinc metalloprotease
UP17_RS07950	COG2176	DNA-directed DNA polymerase activity
UP17_RS07955	COG0779	Required for maturation of 30S ribosomal subunits
UP17_RS07960	COG0195	Participates in both transcription termination and antitermination
UP17_RS07965	COG2740	Nucleic-acid-binding protein implicated in transcription termination
UP17_RS07970	COG1358	cellular component organization or biogenesis
UP17_RS07975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UP17_RS07980	COG1550	Protein conserved in bacteria
UP17_RS07985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UP17_RS07990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UP17_RS07995	COG0196	riboflavin kinase activity
UP17_RS08005	COG1185	polyribonucleotide nucleotidyltransferase activity
UP17_RS08015	COG0726	polysaccharide deacetylase
UP17_RS08020	COG0612	Peptidase, M16
UP17_RS08025	COG1873	PFAM PRC-barrel domain
UP17_RS08030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP17_RS08035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UP17_RS08040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UP17_RS08045	COG0527	aspartate kinase activity
UP17_RS08050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UP17_RS08055	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP17_RS08060	COG0740	serine-type endopeptidase activity
UP17_RS08070	COG4980	gas vesicle protein
UP17_RS08070	COG1674	ftsk spoiiie
UP17_RS08080	COG2188	Transcriptional regulator
UP17_RS08085	COG1744	ABC transporter substrate-binding protein PnrA-like
UP17_RS08090	COG3845	ABC transporter
UP17_RS08095	COG4603	Belongs to the binding-protein-dependent transport system permease family
UP17_RS08100	COG1079	Belongs to the binding-protein-dependent transport system permease family
UP17_RS08105	COG0612	Peptidase, M16
UP17_RS08110	COG0612	Peptidase, M16
UP17_RS08115	COG0300	oxidoreductase activity
UP17_RS08130	COG1426	Protein conserved in bacteria
UP17_RS08135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UP17_RS08140	COG1058	Belongs to the CinA family
UP17_RS08140	COG1546	Belongs to the CinA family
UP17_RS08150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UP17_RS08160	COG1692	metallophosphoesterase
UP17_RS08165	COG2359	stage V sporulation protein S
UP17_RS08175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
UP17_RS08175	COG0674	pyruvate-flavodoxin oxidoreductase activity
UP17_RS08180	COG1013	pyruvate-flavodoxin oxidoreductase activity
UP17_RS08190	COG1063	alcohol dehydrogenase
UP17_RS08195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP17_RS08200	COG4550	Control of competence regulator ComK, YlbF/YmcA
UP17_RS08220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
UP17_RS08225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UP17_RS08235	COG1297	OPT oligopeptide transporter protein
UP17_RS08250	COG0367	asparagine synthase
UP17_RS08255	COG2188	Transcriptional regulator
UP17_RS08260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP17_RS08265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP17_RS08270	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP17_RS08275	COG1486	melibiose metabolic process
UP17_RS08285	COG1252	NADH dehydrogenase
UP17_RS08300	COG2801	Transposase and inactivated derivatives
UP17_RS08310	COG0745	RESPONSE REGULATOR receiver
UP17_RS08315	COG5002	protein histidine kinase activity
UP17_RS08325	COG0577	efflux transmembrane transporter activity
UP17_RS08335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UP17_RS08340	COG1923	regulation of RNA biosynthetic process
UP17_RS08345	COG0464	growth
UP17_RS08350	COG2860	membrane
UP17_RS08355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UP17_RS08360	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
UP17_RS08365	COG0789	Transcriptional regulator
UP17_RS08370	COG0174	glutamine synthetase
UP17_RS08380	COG4974	Belongs to the 'phage' integrase family
UP17_RS08430	COG1595	DNA-templated transcription, initiation
UP17_RS08440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_RS08450	COG1131	(ABC) transporter
UP17_RS08465	COG1136	(ABC) transporter
UP17_RS08470	COG0577	efflux transmembrane transporter activity
UP17_RS08480	COG5002	protein histidine kinase activity
UP17_RS08495	COG1609	Transcriptional regulator
UP17_RS08500	COG1263	PTS System
UP17_RS08500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_RS08505	COG1621	beta-fructofuranosidase activity
UP17_RS08510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP17_RS08515	COG2190	(PTS) system
UP17_RS08530	COG0662	Cupin 2, conserved barrel domain protein
UP17_RS08540	COG2323	membrane
UP17_RS08550	COG2801	Transposase and inactivated derivatives
UP17_RS08605	COG2801	Transposase and inactivated derivatives
UP17_RS08645	COG0277	FAD linked oxidase domain protein
UP17_RS08650	COG2801	Transposase and inactivated derivatives
UP17_RS08680	COG0574	Belongs to the PEP-utilizing enzyme family
UP17_RS08680	COG3848	Pyruvate phosphate dikinase
UP17_RS08715	COG1335	isochorismatase
UP17_RS08725	COG0346	lactoylglutathione lyase activity
UP17_RS08730	COG0346	lactoylglutathione lyase activity
UP17_RS08735	COG0400	carboxylic ester hydrolase activity
UP17_RS08740	COG2267	carboxylic ester hydrolase activity
UP17_RS08775	COG1114	Component of the transport system for branched-chain amino acids
UP17_RS08785	COG1595	DNA-templated transcription, initiation
UP17_RS08805	COG1733	regulation of RNA biosynthetic process
UP17_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS08820	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UP17_RS08820	COG0456	acetyltransferase
UP17_RS08840	COG1757	Na H antiporter
UP17_RS08865	COG3764	Sortase (surface protein transpeptidase)
UP17_RS08890	COG2814	Major facilitator Superfamily
UP17_RS08900	COG0531	amino acid
UP17_RS08910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP17_RS08915	COG2188	Transcriptional regulator
UP17_RS08920	COG2318	DinB family
UP17_RS08960	COG2801	Transposase and inactivated derivatives
UP17_RS08975	COG0252	asparaginase activity
UP17_RS08980	COG1115	amino acid carrier protein
UP17_RS08985	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP17_RS08995	COG0861	Integral membrane protein TerC family
UP17_RS09000	COG1335	isochorismatase
UP17_RS09025	COG0697	spore germination
UP17_RS09035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
UP17_RS09055	COG2329	Antibiotic biosynthesis monooxygenase
UP17_RS09080	COG0642	Histidine kinase
UP17_RS09085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UP17_RS09090	COG0488	(ABC) transporter
UP17_RS09095	COG0789	Transcriptional regulator
UP17_RS09095	COG4978	Transcriptional regulator
UP17_RS09100	COG0531	amino acid
UP17_RS09105	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS09115	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS09130	COG4989	oxidoreductase activity
UP17_RS09135	COG0346	lactoylglutathione lyase activity
UP17_RS09150	COG1288	antiporter activity
UP17_RS09155	COG1473	amidohydrolase
UP17_RS09175	COG1011	Hydrolase
UP17_RS09180	COG4335	DNA alkylation repair
UP17_RS09195	COG1263	PTS System
UP17_RS09195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_RS09200	COG0366	Alpha amylase catalytic
UP17_RS09205	COG2188	Transcriptional regulator
UP17_RS09210	COG2076	Multidrug Resistance protein
UP17_RS09215	COG2076	Multidrug Resistance protein
UP17_RS09240	COG3620	sequence-specific DNA binding
UP17_RS09265	COG1705	Flagellar rod assembly protein muramidase FlgJ
UP17_RS09270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UP17_RS09275	COG1388	LysM domain
UP17_RS09280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UP17_RS09285	COG4224	UPF0291 protein
UP17_RS09300	COG3763	UPF0154 protein
UP17_RS09305	COG1063	alcohol dehydrogenase
UP17_RS09310	COG5577	PFAM Coat F domain
UP17_RS09325	COG5577	PFAM Coat F domain
UP17_RS09340	COG3118	belongs to the thioredoxin family
UP17_RS09345	COG1902	pentaerythritol trinitrate reductase activity
UP17_RS09350	COG2259	Doxx family
UP17_RS09355	COG0785	Cytochrome C biogenesis protein
UP17_RS09365	COG4846	Membrane protein involved in cytochrome C biogenesis
UP17_RS09385	COG0419	ATPase involved in DNA repair
UP17_RS09390	COG0071	Belongs to the small heat shock protein (HSP20) family
UP17_RS09405	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS09410	COG0028	Belongs to the TPP enzyme family
UP17_RS09415	COG0069	glutamate synthase activity
UP17_RS09420	COG2066	Belongs to the glutaminase family
UP17_RS09440	COG0460	homoserine dehydrogenase
UP17_RS09445	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS09450	COG0833	amino acid
UP17_RS09470	COG0833	amino acid
UP17_RS09480	COG4948	Mandelate Racemase Muconate Lactonizing
UP17_RS09490	COG4319	ketosteroid isomerase
UP17_RS09510	COG1937	Protein conserved in bacteria
UP17_RS09520	COG2210	Belongs to the sulfur carrier protein TusA family
UP17_RS09530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_RS09535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_RS09535	COG0425	Belongs to the sulfur carrier protein TusA family
UP17_RS09545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_RS09545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_RS09550	COG0425	Belongs to the sulfur carrier protein TusA family
UP17_RS09555	COG0730	response to heat
UP17_RS09605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP17_RS09615	COG4152	abc transporter atp-binding protein
UP17_RS09620	COG1668	transmembrane transport
UP17_RS09635	COG1937	Protein conserved in bacteria
UP17_RS09640	COG2608	mercury ion transmembrane transporter activity
UP17_RS09645	COG2217	Heavy metal translocating P-type atpase
UP17_RS09650	COG2318	DinB family
UP17_RS09660	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP17_RS09680	COG3540	Alkaline phosphatase
UP17_RS09685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP17_RS09690	COG0805	protein transport
UP17_RS09700	COG1113	amino acid transport
UP17_RS09710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UP17_RS09710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
UP17_RS09720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_RS09725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP17_RS09735	COG2186	Transcriptional regulator
UP17_RS09750	COG2153	protein acetylation
UP17_RS09755	COG1846	Transcriptional regulator
UP17_RS09760	COG1132	(ABC) transporter
UP17_RS09770	COG1846	Transcriptional regulator
UP17_RS09775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP17_RS09780	COG0022	dehydrogenase e1 component
UP17_RS09790	COG0346	lactoylglutathione lyase activity
UP17_RS09805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_RS09810	COG0697	spore germination
UP17_RS09820	COG2271	Major facilitator Superfamily
UP17_RS09825	COG0277	FAD linked oxidase domain protein
UP17_RS09830	COG1309	transcriptional regulator
UP17_RS09845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
UP17_RS09850	COG1228	amidohydrolase
UP17_RS09855	COG2271	Major facilitator Superfamily
UP17_RS09870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
UP17_RS09875	COG1914	H( )-stimulated, divalent metal cation uptake system
UP17_RS09880	COG4336	lyase activity
UP17_RS09885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UP17_RS09890	COG1984	allophanate hydrolase subunit 2
UP17_RS09900	COG0243	molybdopterin cofactor binding
UP17_RS09930	COG2223	nitrite transmembrane transporter activity
UP17_RS09940	COG2197	response regulator
UP17_RS09950	COG4585	Histidine kinase
UP17_RS09955	COG1414	Transcriptional regulator
UP17_RS09970	COG1280	lysine exporter protein (LysE YggA)
UP17_RS09975	COG1378	Sugar-specific transcriptional regulator TrmB
UP17_RS09985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP17_RS09990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_RS09995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_RS10010	COG2358	TRAP transporter, solute receptor (TAXI family
UP17_RS10025	COG0405	Gamma-glutamyltransferase
UP17_RS10035	COG0010	Belongs to the arginase family
UP17_RS10040	COG0786	glutamate:sodium symporter activity
UP17_RS10045	COG2135	peptidase activity
UP17_RS10055	COG0561	phosphatase activity
UP17_RS10060	COG2271	Major facilitator Superfamily
UP17_RS10065	COG0251	oxidation-reduction process
UP17_RS10110	COG0583	DNA-binding transcription factor activity
UP17_RS10120	COG2801	Transposase and inactivated derivatives
UP17_RS10125	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_RS10135	COG2271	Major facilitator Superfamily
UP17_RS10145	COG0657	acetylesterase activity
UP17_RS10150	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS10160	COG2271	Major facilitator Superfamily
UP17_RS10170	COG0583	DNA-binding transcription factor activity
UP17_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS10185	COG0300	oxidoreductase activity
UP17_RS10190	COG1960	acyl-CoA dehydrogenase activity
UP17_RS10200	COG0439	Biotin carboxylase
UP17_RS10205	COG0511	ligase activity, forming carbon-carbon bonds
UP17_RS10210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP17_RS10215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS10220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS10220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS10230	COG0183	Belongs to the thiolase family
UP17_RS10240	COG1404	Belongs to the peptidase S8 family
UP17_RS10255	COG0697	spore germination
UP17_RS10290	COG3842	ATPase activity
UP17_RS10295	COG1349	DNA-binding transcription factor activity
UP17_RS10300	COG0561	phosphatase activity
UP17_RS10305	COG2076	Multidrug Resistance protein
UP17_RS10320	COG3048	D-serine ammonia-lyase activity
UP17_RS10340	COG0583	DNA-binding transcription factor activity
UP17_RS10345	COG1115	amino acid carrier protein
UP17_RS10355	COG1122	ATPase activity
UP17_RS10370	COG0310	cobalt ion transport
UP17_RS10445	COG1492	cobalamin metabolic process
UP17_RS10455	COG0515	serine threonine protein kinase
UP17_RS10465	COG2368	4-hydroxyphenylacetate
UP17_RS10470	COG1414	Transcriptional regulator
UP17_RS10515	COG2814	Major facilitator Superfamily
UP17_RS10530	COG1309	transcriptional regulator
UP17_RS10545	COG0300	oxidoreductase activity
UP17_RS10555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UP17_RS10560	COG4721	ABC-type cobalt transport system, permease component
UP17_RS10565	COG1122	ATPase activity
UP17_RS10575	COG0352	thiamine-phosphate diphosphorylase activity
UP17_RS10580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UP17_RS10590	COG2022	thiamine diphosphate biosynthetic process
UP17_RS10595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UP17_RS10615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UP17_RS10620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_RS10635	COG0824	Thioesterase
UP17_RS10645	COG4841	protein insertion into membrane
UP17_RS10655	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UP17_RS10660	COG1832	CoA-binding protein
UP17_RS10665	COG0187	DNA topoisomerase II activity
UP17_RS10670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UP17_RS10675	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
UP17_RS10680	COG1737	Transcriptional regulator
UP17_RS10685	COG1263	PTS System
UP17_RS10685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_RS10700	COG3876	Protein conserved in bacteria
UP17_RS10705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_RS10705	COG1263	PTS System
UP17_RS10715	COG0673	inositol 2-dehydrogenase activity
UP17_RS10750	COG3279	Response regulator of the LytR AlgR family
UP17_RS10760	COG3290	protein histidine kinase activity
UP17_RS10765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UP17_RS10780	COG0738	Major facilitator superfamily
UP17_RS10805	COG2801	Transposase and inactivated derivatives
UP17_RS10825	COG0789	Transcriptional regulator
UP17_RS10830	COG2814	Major facilitator Superfamily
UP17_RS10840	COG3964	amidohydrolase
UP17_RS10860	COG2188	Transcriptional regulator
UP17_RS10885	COG1414	Transcriptional regulator
UP17_RS10900	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS10905	COG0028	Belongs to the TPP enzyme family
UP17_RS10915	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
UP17_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS10940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP17_RS10975	COG1819	glycosyl
UP17_RS10980	COG2801	Transposase and inactivated derivatives
UP17_RS11015	COG0672	)-iron permease
UP17_RS11025	COG0583	DNA-binding transcription factor activity
UP17_RS11030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UP17_RS11035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UP17_RS11060	COG1231	oxidoreductase activity
UP17_RS11070	COG1309	transcriptional regulator
UP17_RS11075	COG1960	acyl-CoA dehydrogenase activity
UP17_RS11080	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_RS11085	COG0439	Biotin carboxylase
UP17_RS11090	COG0511	ligase activity, forming carbon-carbon bonds
UP17_RS11095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UP17_RS11100	COG1024	Enoyl-CoA hydratase
UP17_RS11105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP17_RS11115	COG1335	isochorismatase
UP17_RS11120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UP17_RS11125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UP17_RS11165	COG5444	nuclease activity
UP17_RS11185	COG1876	peptidase activity
UP17_RS11225	COG2801	Transposase and inactivated derivatives
UP17_RS11230	COG2851	Citrate transporter
UP17_RS11240	COG0583	DNA-binding transcription factor activity
UP17_RS11245	COG1053	succinate dehydrogenase
UP17_RS11250	COG2828	Protein conserved in bacteria
UP17_RS11255	COG0583	DNA-binding transcription factor activity
UP17_RS11260	COG2851	Citrate transporter
UP17_RS11275	COG0583	DNA-binding transcription factor activity
UP17_RS11310	COG2205	protein histidine kinase activity
UP17_RS11315	COG3344	reverse transcriptase
UP17_RS11330	COG2801	Transposase and inactivated derivatives
UP17_RS11345	COG0456	acetyltransferase
UP17_RS11370	COG3344	reverse transcriptase
UP17_RS11430	COG1733	regulation of RNA biosynthetic process
UP17_RS11435	COG0778	Nitroreductase
UP17_RS11450	COG2318	DinB family
UP17_RS11470	COG1522	sequence-specific DNA binding
UP17_RS11475	COG4257	antibiotic catabolic process
UP17_RS11545	COG0840	transmembrane signaling receptor activity
UP17_RS11550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP17_RS11560	COG2814	Major facilitator Superfamily
UP17_RS11570	COG1742	UPF0060 membrane protein
UP17_RS11575	COG0697	spore germination
UP17_RS11645	COG2244	polysaccharide biosynthetic process
UP17_RS11655	COG0833	amino acid
UP17_RS11700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_RS11725	COG4948	Mandelate Racemase Muconate Lactonizing
UP17_RS11740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UP17_RS11750	COG0741	lytic transglycosylase activity
UP17_RS11765	COG2318	DinB family
UP17_RS11785	COG0024	Methionine aminopeptidase
UP17_RS11790	COG2801	Transposase and inactivated derivatives
UP17_RS11810	COG2801	Transposase and inactivated derivatives
UP17_RS11820	COG1160	GTP binding
UP17_RS11825	COG1960	acyl-CoA dehydrogenase activity
UP17_RS11835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP17_RS11840	COG1473	amidohydrolase
UP17_RS11850	COG1113	amino acid transport
UP17_RS11855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UP17_RS11865	COG0509	glycine decarboxylation via glycine cleavage system
UP17_RS11870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP17_RS11875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP17_RS11880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UP17_RS11890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP17_RS11895	COG0788	formyltetrahydrofolate deformylase activity
UP17_RS11905	COG1760	l-serine dehydratase
UP17_RS11910	COG1760	l-serine dehydratase
UP17_RS11915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP17_RS11920	COG0022	dehydrogenase e1 component
UP17_RS11925	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_RS11930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP17_RS11935	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS11940	COG3284	Transcriptional regulator
UP17_RS11950	COG2720	vancomycin resistance protein
UP17_RS11960	COG0586	Pfam SNARE associated Golgi protein
UP17_RS11965	COG1183	phosphatidylcholine synthase activity
UP17_RS11970	COG0586	Pfam SNARE associated Golgi protein
UP17_RS11980	COG0697	spore germination
UP17_RS11985	COG1802	Transcriptional regulator
UP17_RS11990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UP17_RS11995	COG0596	Alpha beta hydrolase
UP17_RS12020	COG2068	MobA-Related Protein
UP17_RS12025	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
UP17_RS12035	COG0247	lactate metabolic process
UP17_RS12040	COG0277	FAD linked oxidase domain protein
UP17_RS12055	COG1176	ABC-type spermidine putrescine transport system, permease component I
UP17_RS12060	COG3842	ATPase activity
UP17_RS12065	COG1840	ABC-type Fe3 transport system, periplasmic component
UP17_RS12075	COG2204	response regulator
UP17_RS12080	COG3852	Histidine kinase
UP17_RS12085	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
UP17_RS12095	COG0640	Transcriptional regulator
UP17_RS12120	COG2223	nitrite transmembrane transporter activity
UP17_RS12125	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
UP17_RS12145	COG0668	transmembrane transport
UP17_RS12170	COG2610	gluconate transmembrane transporter activity
UP17_RS12175	COG1929	Belongs to the glycerate kinase type-1 family
UP17_RS12185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UP17_RS12215	COG0579	oxidoreductase
UP17_RS12220	COG1802	Transcriptional regulator
UP17_RS12240	COG1309	transcriptional regulator
UP17_RS12245	COG0582	viral genome integration into host DNA
UP17_RS12250	COG4294	response to UV
UP17_RS12255	COG0626	cystathionine gamma-synthase activity
UP17_RS12275	COG1131	(ABC) transporter
UP17_RS12280	COG1725	Transcriptional regulator
UP17_RS12295	COG1523	belongs to the glycosyl hydrolase 13 family
UP17_RS12305	COG0542	response to heat
UP17_RS12310	COG1388	LysM domain
UP17_RS12310	COG0791	NLP P60 protein
UP17_RS12330	COG0583	DNA-binding transcription factor activity
UP17_RS12340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
UP17_RS12345	COG1174	glycine betaine transport
UP17_RS12350	COG1732	Glycine betaine
UP17_RS12355	COG1174	glycine betaine transport
UP17_RS12360	COG1125	glycine betaine transport
UP17_RS12360	COG0517	IMP dehydrogenase activity
UP17_RS12365	COG1960	acyl-CoA dehydrogenase activity
UP17_RS12390	COG5002	protein histidine kinase activity
UP17_RS12395	COG0745	RESPONSE REGULATOR receiver
UP17_RS12415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UP17_RS12420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UP17_RS12425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP17_RS12435	COG3048	D-serine ammonia-lyase activity
UP17_RS12455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS12455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS12460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS12475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UP17_RS12480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UP17_RS12505	COG1819	glycosyl
UP17_RS12515	COG4974	Belongs to the 'phage' integrase family
UP17_RS12530	COG0488	(ABC) transporter
UP17_RS12565	COG2610	gluconate transmembrane transporter activity
UP17_RS12575	COG3290	protein histidine kinase activity
UP17_RS12575	COG3829	transcription factor binding
UP17_RS12590	COG2234	aminopeptidase activity
UP17_RS12620	COG0671	phosphoesterase, PA-phosphatase related
UP17_RS12650	COG2244	polysaccharide biosynthetic process
UP17_RS12670	COG2304	oxidoreductase activity
UP17_RS12690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP17_RS12725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UP17_RS12730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP17_RS12755	COG2801	Transposase and inactivated derivatives
UP17_RS12820	COG2259	Doxx family
UP17_RS12825	COG0501	Belongs to the peptidase M48B family
UP17_RS12835	COG0702	epimerase
UP17_RS12840	COG0406	alpha-ribazole phosphatase activity
UP17_RS12860	COG0708	Exodeoxyribonuclease III
UP17_RS12865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_RS12870	COG0297	glycogen (starch) synthase activity
UP17_RS12875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
UP17_RS12880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
UP17_RS12885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
UP17_RS12905	COG3663	DNA glycosylase
UP17_RS12930	COG0730	response to heat
UP17_RS12955	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UP17_RS12960	COG0529	Catalyzes the synthesis of activated sulfate
UP17_RS12965	COG2046	Belongs to the sulfate adenylyltransferase family
UP17_RS12970	COG0175	sulfate reduction
UP17_RS12975	COG0431	NADPH-dependent FMN reductase
UP17_RS12990	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
UP17_RS12995	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
UP17_RS13000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_RS13020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP17_RS13025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP17_RS13035	COG1164	Oligoendopeptidase f
UP17_RS13045	COG3403	YqcI/YcgG family
UP17_RS13070	COG2197	response regulator
UP17_RS13080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP17_RS13085	COG2223	nitrite transmembrane transporter activity
UP17_RS13090	COG0628	permease
UP17_RS13100	COG1376	ErfK ybiS ycfS ynhG family protein
UP17_RS13125	COG0679	Auxin Efflux Carrier
UP17_RS13130	COG0590	tRNA wobble adenosine to inosine editing
UP17_RS13140	COG2706	6-phosphogluconolactonase activity
UP17_RS13155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_RS13160	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS13165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP17_RS13175	COG1278	Cold shock
UP17_RS13180	COG1024	Enoyl-CoA hydratase
UP17_RS13185	COG4608	Belongs to the ABC transporter superfamily
UP17_RS13190	COG0444	Belongs to the ABC transporter superfamily
UP17_RS13195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP17_RS13200	COG0601	transmembrane transport
UP17_RS13205	COG4166	transmembrane transport
UP17_RS13225	COG2340	Cysteine-rich secretory protein family
UP17_RS13235	COG2176	DNA-directed DNA polymerase activity
UP17_RS13240	COG1511	domain protein
UP17_RS13250	COG0561	phosphatase activity
UP17_RS13270	COG0833	amino acid
UP17_RS13285	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS13290	COG0861	Integral membrane protein TerC family
UP17_RS13300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP17_RS13305	COG0604	alcohol dehydrogenase
UP17_RS13310	COG2046	Belongs to the sulfate adenylyltransferase family
UP17_RS13315	COG0529	Catalyzes the synthesis of activated sulfate
UP17_RS13320	COG0730	response to heat
UP17_RS13325	COG0463	Glycosyl transferase, family 2
UP17_RS13325	COG1216	Glycosyl transferase, family 2
UP17_RS13330	COG0438	transferase activity, transferring glycosyl groups
UP17_RS13345	COG1216	Glycosyl transferase, family 2
UP17_RS13345	COG0463	Glycosyl transferase, family 2
UP17_RS13355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UP17_RS13360	COG1086	Polysaccharide biosynthesis protein
UP17_RS13370	COG1132	(ABC) transporter
UP17_RS13385	COG1388	LysM domain
UP17_RS13385	COG3858	chitin binding
UP17_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS13395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_RS13400	COG1937	Protein conserved in bacteria
UP17_RS13410	COG1027	Aspartate ammonia-lyase
UP17_RS13415	COG0252	asparaginase activity
UP17_RS13420	COG1396	sequence-specific DNA binding
UP17_RS13435	COG2040	homocysteine
UP17_RS13440	COG0833	amino acid
UP17_RS13445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UP17_RS13450	COG0400	carboxylic ester hydrolase activity
UP17_RS13455	COG0346	lactoylglutathione lyase activity
UP17_RS13460	COG0346	lactoylglutathione lyase activity
UP17_RS13480	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS13485	COG1764	response to oxidative stress
UP17_RS13490	COG3344	reverse transcriptase
UP17_RS13515	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
UP17_RS13520	COG1733	regulation of RNA biosynthetic process
UP17_RS13535	COG4946	Tricorn protease homolog
UP17_RS13535	COG1506	peptidase
UP17_RS13535	COG0823	Involved in the tonB-independent uptake of proteins
UP17_RS13540	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
UP17_RS13545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_RS13550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP17_RS13555	COG1131	(ABC) transporter
UP17_RS13565	COG0385	Bile acid
UP17_RS13570	COG2814	Major facilitator Superfamily
UP17_RS13575	COG5002	protein histidine kinase activity
UP17_RS13580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_RS13595	COG0514	ATP-dependent DNA helicase (RecQ)
UP17_RS13600	COG1388	LysM domain
UP17_RS13600	COG3584	3D domain protein
UP17_RS13615	COG3546	catalase activity
UP17_RS13620	COG2996	Protein conserved in bacteria
UP17_RS13645	COG1247	-acetyltransferase
UP17_RS13650	COG3973	AAA domain
UP17_RS13660	COG1714	RDD family
UP17_RS13665	COG0488	(ABC) transporter
UP17_RS13680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP17_RS13685	COG1621	beta-fructofuranosidase activity
UP17_RS13690	COG1172	Belongs to the binding-protein-dependent transport system permease family
UP17_RS13695	COG1129	ABC transporter
UP17_RS13700	COG1879	ABC-type sugar transport system periplasmic component
UP17_RS13705	COG1349	DNA-binding transcription factor activity
UP17_RS13710	COG1621	beta-fructofuranosidase activity
UP17_RS13715	COG1621	beta-fructofuranosidase activity
UP17_RS13720	COG2182	Extracellular solute-binding protein
UP17_RS13725	COG4753	response regulator
UP17_RS13725	COG2207	Transcriptional regulator
UP17_RS13730	COG2972	Histidine kinase
UP17_RS13735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_RS13745	COG2801	Transposase and inactivated derivatives
UP17_RS13755	COG0069	glutamate synthase activity
UP17_RS13770	COG2268	Band 7 protein
UP17_RS13820	COG2801	Transposase and inactivated derivatives
UP17_RS13845	COG0697	spore germination
UP17_RS13850	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS13855	COG2271	Major facilitator Superfamily
UP17_RS13865	COG1454	alcohol dehydrogenase
UP17_RS13870	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS13885	COG1063	alcohol dehydrogenase
UP17_RS13890	COG5577	PFAM Coat F domain
UP17_RS13925	COG2268	Band 7 protein
UP17_RS13930	COG1585	Membrane protein implicated in regulation of membrane protease activity
UP17_RS13935	COG1268	BioY protein
UP17_RS13950	COG1272	protein, Hemolysin III
UP17_RS13960	COG3773	Cell wall hydrolase
UP17_RS13970	COG0432	Pfam Uncharacterised protein family UPF0047
UP17_RS13980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP17_RS13980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_RS13980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP17_RS13985	COG1105	Belongs to the carbohydrate kinase PfkB family
UP17_RS13990	COG1349	DNA-binding transcription factor activity
UP17_RS13995	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_RS14000	COG0567	Dehydrogenase, E1 component
UP17_RS14005	COG3384	dioxygenase
UP17_RS14015	COG1410	methionine synthase
UP17_RS14015	COG0646	methionine synthase
UP17_RS14020	COG0646	methionine synthase
UP17_RS14020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
UP17_RS14025	COG2258	MOSC domain
UP17_RS14030	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
UP17_RS14035	COG1793	dna ligase
UP17_RS14035	COG3285	dna ligase
UP17_RS14045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UP17_RS14055	COG0288	reversible hydration of carbon dioxide
UP17_RS14085	COG1346	cytolysis
UP17_RS14095	COG0668	transmembrane transport
UP17_RS14100	COG0534	Mate efflux family protein
UP17_RS14105	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS14115	COG2340	Cysteine-rich secretory protein family
UP17_RS14125	COG5002	protein histidine kinase activity
UP17_RS14130	COG0745	RESPONSE REGULATOR receiver
UP17_RS14150	COG0523	cobalamin synthesis protein
UP17_RS14155	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
UP17_RS14160	COG0235	Class ii aldolase
UP17_RS14165	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
UP17_RS14170	COG1850	ribulose-bisphosphate carboxylase activity
UP17_RS14175	COG0436	Aminotransferase
UP17_RS14180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UP17_RS14185	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
UP17_RS14190	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
UP17_RS14200	COG3409	Peptidoglycan-binding domain 1 protein
UP17_RS14200	COG0793	Belongs to the peptidase S41A family
UP17_RS14205	COG0813	purine-nucleoside phosphorylase activity
UP17_RS14215	COG4191	Histidine kinase
UP17_RS14220	COG4479	Belongs to the UPF0346 family
UP17_RS14230	COG1509	lysine 2,3-aminomutase activity
UP17_RS14235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
UP17_RS14240	COG1845	cytochrome c oxidase, subunit III
UP17_RS14255	COG1113	amino acid transport
UP17_RS14260	COG1113	amino acid transport
UP17_RS14275	COG1509	lysine 2,3-aminomutase activity
UP17_RS14280	COG3829	transcription factor binding
UP17_RS14285	COG0456	acetyltransferase
UP17_RS14290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_RS14295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UP17_RS14300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UP17_RS14305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_RS14315	COG1619	proteins homologs of microcin C7 resistance protein MccF
UP17_RS14325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP17_RS14345	COG2755	lipolytic protein G-D-S-L family
UP17_RS14350	COG1999	signal sequence binding
UP17_RS14355	COG1307	EDD domain protein, DegV family
UP17_RS14365	COG0805	protein transport
UP17_RS14370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP17_RS14375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UP17_RS14380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UP17_RS14405	COG0861	Integral membrane protein TerC family
UP17_RS14415	COG0405	Gamma-glutamyltransferase
UP17_RS14420	COG2521	methyltransferase
UP17_RS14420	COG2136	Putative SAM-dependent methyltransferase
UP17_RS14430	COG0129	dihydroxy-acid dehydratase activity
UP17_RS14435	COG1413	lyase activity
UP17_RS14440	COG0488	(ABC) transporter
UP17_RS14445	COG1418	mRNA catabolic process
UP17_RS14450	COG1307	EDD domain protein, DegV family
UP17_RS14455	COG0386	Belongs to the glutathione peroxidase family
UP17_RS14465	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
UP17_RS14480	COG1321	iron dependent repressor
UP17_RS14485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UP17_RS14490	COG1396	sequence-specific DNA binding
UP17_RS14495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP17_RS14505	COG1620	l-lactate permease
UP17_RS14515	COG2205	protein histidine kinase activity
UP17_RS14525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
UP17_RS14530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
UP17_RS14540	COG5609	conserved protein (DUF2294)
UP17_RS14550	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP17_RS14580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_RS14595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_RS14600	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS14615	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS14620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UP17_RS14635	COG0569	domain protein
UP17_RS14640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UP17_RS14650	COG2814	Major facilitator Superfamily
UP17_RS14655	COG4565	transcriptional regulatory protein
UP17_RS14660	COG3290	protein histidine kinase activity
UP17_RS14670	COG3493	citrate carrier protein
UP17_RS14700	COG2814	Major facilitator Superfamily
UP17_RS14735	COG0640	Transcriptional regulator
UP17_RS14750	COG0702	epimerase
UP17_RS14755	COG1737	Transcriptional regulator
UP17_RS14760	COG2971	BadF BadG BcrA BcrD
UP17_RS14770	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP17_RS14775	COG1486	melibiose metabolic process
UP17_RS14785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP17_RS14810	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS14815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UP17_RS14855	COG0833	amino acid
UP17_RS14860	COG1834	amidinotransferase
UP17_RS14870	COG1288	antiporter activity
UP17_RS14875	COG4187	Peptidase family M20/M25/M40
UP17_RS14880	COG2235	arginine
UP17_RS14905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP17_RS14910	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
UP17_RS14915	COG3716	PTS system mannose fructose sorbose family IID component
UP17_RS14920	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_RS14930	COG1737	Transcriptional regulator
UP17_RS14940	COG0531	amino acid
UP17_RS14980	COG1511	domain protein
UP17_RS15000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UP17_RS15005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UP17_RS15015	COG1959	2 iron, 2 sulfur cluster binding
UP17_RS15030	COG0328	RNA-DNA hybrid ribonuclease activity
UP17_RS15035	COG0328	RNA-DNA hybrid ribonuclease activity
UP17_RS15050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP17_RS15065	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UP17_RS15070	COG1755	Isoprenylcysteine carboxyl methyltransferase
UP17_RS15075	COG3424	synthase
UP17_RS15080	COG2233	PERMEase
UP17_RS15085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP17_RS15090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
UP17_RS15095	COG1199	ATP-dependent helicase activity
UP17_RS15100	COG1278	Cold shock
UP17_RS15105	COG0116	Belongs to the methyltransferase superfamily
UP17_RS15115	COG3599	regulation of cell shape
UP17_RS15125	COG3359	exonuclease
UP17_RS15130	COG1111	helicase
UP17_RS15130	COG1205	dead DEAH box helicase
UP17_RS15165	COG3331	DNA recombination
UP17_RS15170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP17_RS15170	COG4499	WXG100 protein secretion system (Wss), protein YukC
UP17_RS15180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UP17_RS15185	COG3935	DnaD domain protein
UP17_RS15190	COG0017	Asparaginyl-tRNA synthetase
UP17_RS15195	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP17_RS15215	COG0583	DNA-binding transcription factor activity
UP17_RS15220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_RS15245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UP17_RS15255	COG0436	Aminotransferase
UP17_RS15265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UP17_RS15265	COG1199	ATP-dependent helicase activity
UP17_RS15270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
UP17_RS15280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UP17_RS15290	COG0617	tRNA 3'-terminal CCA addition
UP17_RS15295	COG0438	transferase activity, transferring glycosyl groups
UP17_RS15300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP17_RS15305	COG1803	Methylglyoxal synthase
UP17_RS15315	COG1694	Mazg nucleotide pyrophosphohydrolase
UP17_RS15320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_RS15330	COG2738	Putative neutral zinc metallopeptidase
UP17_RS15340	COG4347	Protein of unknown function (DUF1405)
UP17_RS15345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UP17_RS15345	COG2010	Cytochrome c
UP17_RS15365	COG5582	Belongs to the UPF0302 family
UP17_RS15370	COG0457	Tetratricopeptide repeat
UP17_RS15375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UP17_RS15380	COG0287	Prephenate dehydrogenase
UP17_RS15385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UP17_RS15390	COG4401	Chorismate mutase type I
UP17_RS15395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UP17_RS15400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UP17_RS15405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UP17_RS15410	COG0105	UTP biosynthetic process
UP17_RS15415	COG0142	geranyltranstransferase activity
UP17_RS15420	COG2226	methyltransferase
UP17_RS15425	COG0142	geranyltranstransferase activity
UP17_RS15435	COG0302	gtp cyclohydrolase
UP17_RS15440	COG0776	regulation of translation
UP17_RS15445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UP17_RS15470	COG3290	protein histidine kinase activity
UP17_RS15470	COG3829	transcription factor binding
UP17_RS15485	COG0531	amino acid
UP17_RS15490	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UP17_RS15510	COG0539	negative regulation of cytoplasmic translation
UP17_RS15520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UP17_RS15530	COG2959	enzyme of heme biosynthesis
UP17_RS15535	COG3773	Cell wall hydrolase
UP17_RS15535	COG3409	Peptidoglycan-binding domain 1 protein
UP17_RS15540	COG2339	peptidase activity
UP17_RS15550	COG0492	ferredoxin-NADP+ reductase activity
UP17_RS15555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP17_RS15560	COG4862	establishment of competence for transformation
UP17_RS15570	COG1408	metallophosphoesterase
UP17_RS15580	COG1388	LysM domain
UP17_RS15585	COG1266	CAAX protease self-immunity
UP17_RS15590	COG0514	ATP-dependent DNA helicase (RecQ)
UP17_RS15595	COG4955	Helix-turn-helix domain
UP17_RS15605	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
UP17_RS15615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UP17_RS15625	COG1595	DNA-templated transcription, initiation
UP17_RS15630	COG5002	protein histidine kinase activity
UP17_RS15635	COG0745	RESPONSE REGULATOR receiver
UP17_RS15640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UP17_RS15645	COG1333	cytochrome c biogenesis protein
UP17_RS15650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_RS15655	COG1187	pseudouridine synthase activity
UP17_RS15660	COG0700	Nucleoside recognition
UP17_RS15665	COG2715	membrane protein required for spore maturation
UP17_RS15670	COG1686	Belongs to the peptidase S11 family
UP17_RS15685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UP17_RS15700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
UP17_RS15710	COG1547	Domain of unknown function (DUF309)
UP17_RS15720	COG4086	secreted protein
UP17_RS15730	COG0697	spore germination
UP17_RS15750	COG2252	PERMEase
UP17_RS15760	COG2172	sigma factor antagonist activity
UP17_RS15770	COG1686	Belongs to the peptidase S11 family
UP17_RS15790	COG4974	Belongs to the 'phage' integrase family
UP17_RS15800	COG0735	belongs to the Fur family
UP17_RS15805	COG1300	Membrane
UP17_RS15815	COG1379	DNA repair
UP17_RS15825	COG0667	Aldo Keto reductase
UP17_RS15830	COG1764	response to oxidative stress
UP17_RS15835	COG1846	Transcriptional regulator
UP17_RS15845	COG1073	alpha beta
UP17_RS15850	COG4918	Iron-sulphur cluster biosynthesis
UP17_RS15860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UP17_RS15865	COG0791	NLP P60 protein
UP17_RS15865	COG1388	LysM domain
UP17_RS15875	COG0300	oxidoreductase activity
UP17_RS15880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_RS15885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP17_RS15895	COG0789	Transcriptional regulator
UP17_RS15925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
UP17_RS15935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UP17_RS15940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UP17_RS15945	COG2195	Cleaves the N-terminal amino acid of tripeptides
UP17_RS15950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP17_RS15955	COG0346	lactoylglutathione lyase activity
UP17_RS15960	COG1376	ErfK ybiS ycfS ynhG family protein
UP17_RS15965	COG4129	membrane
UP17_RS15970	COG1126	abc transporter atp-binding protein
UP17_RS15975	COG0765	amino acid transport
UP17_RS15980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP17_RS15995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS15995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS16000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS16010	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_RS16015	COG0022	dehydrogenase e1 component
UP17_RS16020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP17_RS16025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP17_RS16050	COG0584	glycerophosphoryl diester phosphodiesterase
UP17_RS16060	COG0745	RESPONSE REGULATOR receiver
UP17_RS16065	COG0750	zinc metalloprotease
UP17_RS16070	COG0497	DNA recombination
UP17_RS16075	COG1438	arginine binding
UP17_RS16080	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
UP17_RS16085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UP17_RS16095	COG1722	exodeoxyribonuclease VII activity
UP17_RS16100	COG1570	exodeoxyribonuclease VII activity
UP17_RS16105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UP17_RS16110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UP17_RS16115	COG1302	Protein conserved in bacteria
UP17_RS16120	COG0439	Biotin carboxylase
UP17_RS16125	COG0511	ligase activity, forming carbon-carbon bonds
UP17_RS16165	COG3854	ATPases associated with a variety of cellular activities
UP17_RS16170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UP17_RS16175	COG0006	proline dipeptidase activity
UP17_RS16190	COG3872	metal-dependent enzyme
UP17_RS16200	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP17_RS16215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP17_RS16220	COG0095	Lipoate-protein ligase
UP17_RS16225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_RS16235	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP17_RS16245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP17_RS16280	COG4537	Required for transformation and DNA binding
UP17_RS16285	COG1459	type II secretion system
UP17_RS16290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UP17_RS16415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UP17_RS16420	COG1393	Belongs to the ArsC family
UP17_RS16440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_RS16460	COG1368	sulfuric ester hydrolase activity
UP17_RS16465	COG1940	carbohydrate kinase activity
UP17_RS16480	COG0457	Tetratricopeptide repeat
UP17_RS16480	COG0705	Rhomboid family
UP17_RS16490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
UP17_RS16515	COG0704	Plays a role in the regulation of phosphate uptake
UP17_RS16525	COG0581	inorganic phosphate transmembrane transporter activity
UP17_RS16530	COG0573	inorganic phosphate transmembrane transporter activity
UP17_RS16535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UP17_RS16540	COG0768	penicillin binding
UP17_RS16545	COG0477	Major facilitator Superfamily
UP17_RS16555	COG2839	Protein conserved in bacteria
UP17_RS16560	COG5521	maltodextrose utilization protein MalA
UP17_RS16570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UP17_RS16575	COG4709	membrane
UP17_RS16580	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
UP17_RS16585	COG0735	belongs to the Fur family
UP17_RS16590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UP17_RS16595	COG1121	(ABC) transporter
UP17_RS16605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
UP17_RS16610	COG0513	Belongs to the DEAD box helicase family
UP17_RS16625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UP17_RS16630	COG2384	SAM-dependent methyltransferase
UP17_RS16635	COG2010	Cytochrome c
UP17_RS16645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UP17_RS16650	COG0358	DNA primase activity
UP17_RS16655	COG1671	Belongs to the UPF0178 family
UP17_RS16660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
UP17_RS16665	COG0517	IMP dehydrogenase activity
UP17_RS16670	COG0751	glycine-tRNA ligase activity
UP17_RS16675	COG0752	glycyl-tRNA synthetase alpha subunit
UP17_RS16680	COG1381	Involved in DNA repair and RecF pathway recombination
UP17_RS16685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UP17_RS16690	COG0295	cytidine deaminase activity
UP17_RS16695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UP17_RS16705	COG1480	7TM receptor with intracellular HD hydrolase
UP17_RS16710	COG1702	phosphate starvation-inducible protein PhoH
UP17_RS16730	COG4864	UPF0365 protein
UP17_RS16735	COG1030	water channel activity
UP17_RS16740	COG1610	YqeY-like protein
UP17_RS16745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UP17_RS16750	COG1283	sodium-dependent phosphate transmembrane transporter activity
UP17_RS16755	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
UP17_RS16760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP17_RS16765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UP17_RS16770	COG2264	protein methyltransferase activity
UP17_RS16780	COG0443	Heat shock 70 kDa protein
UP17_RS16785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UP17_RS16790	COG1420	regulation of RNA biosynthetic process
UP17_RS16795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UP17_RS16810	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP17_RS16820	COG0268	Binds directly to 16S ribosomal RNA
UP17_RS16825	COG1466	dna polymerase III delta subunit
UP17_RS16830	COG2333	competence protein COMEC
UP17_RS16830	COG0658	competence protein
UP17_RS16835	COG2131	deaminase
UP17_RS16840	COG1596	polysaccharide export
UP17_RS16840	COG1555	photosystem II stabilization
UP17_RS16845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP17_RS16850	COG2226	methyltransferase
UP17_RS16855	COG0799	negative regulation of ribosome biogenesis
UP17_RS16860	COG1713	HD superfamily hydrolase involved in NAD metabolism
UP17_RS16865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UP17_RS16870	COG1534	Rna-binding protein
UP17_RS16880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
UP17_RS16885	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
UP17_RS16890	COG0688	phosphatidylethanolamine metabolic process
UP17_RS16895	COG1183	phosphatidylcholine synthase activity
UP17_RS16920	COG0626	cystathionine gamma-synthase activity
UP17_RS16925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP17_RS16935	COG2226	methyltransferase
UP17_RS16950	COG0768	penicillin binding
UP17_RS16955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UP17_RS16975	COG0572	uridine kinase
UP17_RS16980	COG0826	peptidase U32
UP17_RS16985	COG0826	peptidase U32
UP17_RS16990	COG4122	O-methyltransferase activity
UP17_RS17000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UP17_RS17005	COG3906	Belongs to the UPF0473 family
UP17_RS17010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
UP17_RS17025	COG0628	permease
UP17_RS17035	COG3881	PFAM PRC-barrel domain
UP17_RS17040	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
UP17_RS17045	COG1704	LemA family
UP17_RS17050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UP17_RS17060	COG0482	sulfurtransferase activity
UP17_RS17065	COG1104	cysteine desulfurase activity
UP17_RS17070	COG1959	2 iron, 2 sulfur cluster binding
UP17_RS17080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UP17_RS17095	COG1131	(ABC) transporter
UP17_RS17100	COG1725	Transcriptional regulator
UP17_RS17110	COG1316	TRANSCRIPTIONal
UP17_RS17125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UP17_RS17130	COG1132	(ABC) transporter
UP17_RS17185	COG1216	Glycosyl transferase, family 2
UP17_RS17185	COG1442	glycosyl transferase family 8
UP17_RS17200	COG0438	transferase activity, transferring glycosyl groups
UP17_RS17210	COG0438	transferase activity, transferring glycosyl groups
UP17_RS17215	COG0438	transferase activity, transferring glycosyl groups
UP17_RS17225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UP17_RS17230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP17_RS17245	COG4464	protein tyrosine phosphatase activity
UP17_RS17250	COG0489	protein tyrosine kinase activity
UP17_RS17265	COG3420	alginic acid biosynthetic process
UP17_RS17265	COG5434	Belongs to the glycosyl hydrolase 28 family
UP17_RS17280	COG2814	Major facilitator Superfamily
UP17_RS17300	COG0411	ABC transporter
UP17_RS17330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UP17_RS17350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
UP17_RS17355	COG0124	histidyl-tRNA synthetase
UP17_RS17360	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP17_RS17360	COG4991	sh3 domain protein
UP17_RS17360	COG3103	Sh3 type 3 domain protein
UP17_RS17365	COG1490	D-aminoacyl-tRNA deacylase activity
UP17_RS17370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UP17_RS17375	COG2801	Transposase and inactivated derivatives
UP17_RS17385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP17_RS17390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UP17_RS17390	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
UP17_RS17395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UP17_RS17395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UP17_RS17405	COG2244	polysaccharide biosynthetic process
UP17_RS17410	COG2323	membrane
UP17_RS17420	COG1862	Preprotein translocase
UP17_RS17430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
UP17_RS17445	COG0632	four-way junction helicase activity
UP17_RS17475	COG0157	Belongs to the NadC ModD family
UP17_RS17480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
UP17_RS17485	COG1104	cysteine desulfurase activity
UP17_RS17490	COG1827	regulation of RNA biosynthetic process
UP17_RS17495	COG0077	Prephenate dehydratase
UP17_RS17500	COG4492	Belongs to the UPF0735 family
UP17_RS17505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UP17_RS17510	COG3290	protein histidine kinase activity
UP17_RS17520	COG2868	ribosomal protein
UP17_RS17525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UP17_RS17530	COG1530	ribonuclease E activity
UP17_RS17535	COG1994	Peptidase M50
UP17_RS17540	COG0739	heme binding
UP17_RS17550	COG1098	S1 RNA binding domain
UP17_RS17555	COG2894	cell division
UP17_RS17570	COG1792	Involved in formation and maintenance of cell shape
UP17_RS17580	COG1077	Cell shape determining protein MreB Mrl
UP17_RS17585	COG2003	Belongs to the UPF0758 family
UP17_RS17600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
UP17_RS17610	COG0285	dihydrofolate synthase activity
UP17_RS17620	COG0189	ligase activity
UP17_RS17625	COG0525	valine-tRNA ligase activity
UP17_RS17635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP17_RS17640	COG1388	LysM domain
UP17_RS17645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UP17_RS17650	COG0113	porphobilinogen synthase activity
UP17_RS17660	COG0181	hydroxymethylbilane synthase activity
UP17_RS17665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UP17_RS17680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UP17_RS17685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UP17_RS17690	COG1067	ATP-dependent peptidase activity
UP17_RS17690	COG0470	DNA polymerase III
UP17_RS17700	COG0544	peptidyl-prolyl cis-trans isomerase activity
UP17_RS17710	COG0066	3-isopropylmalate dehydratase activity
UP17_RS17715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UP17_RS17725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UP17_RS17730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UP17_RS17735	COG0440	acetolactate synthase activity
UP17_RS17740	COG0028	Belongs to the TPP enzyme family
UP17_RS17810	COG0622	Phosphoesterase
UP17_RS17815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UP17_RS17835	COG5401	PFAM Sporulation and spore germination
UP17_RS17845	COG1846	Transcriptional regulator
UP17_RS17850	COG2197	response regulator
UP17_RS17855	COG0824	Thioesterase
UP17_RS17860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UP17_RS17865	COG1053	succinate dehydrogenase
UP17_RS17870	COG2009	succinate dehydrogenase
UP17_RS17875	COG1719	4-vinyl reductase, 4VR
UP17_RS17890	COG3118	belongs to the thioredoxin family
UP17_RS17895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UP17_RS17900	COG2086	electron transfer activity
UP17_RS17905	COG1024	Enoyl-CoA hydratase
UP17_RS17910	COG1309	transcriptional regulator
UP17_RS17915	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_RS17925	COG3766	membrane
UP17_RS17935	COG1796	DNA polymerase
UP17_RS17935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UP17_RS17940	COG1286	toxin biosynthetic process
UP17_RS17945	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
UP17_RS17950	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UP17_RS17955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP17_RS17955	COG0072	phenylalanine-tRNA ligase activity
UP17_RS17960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UP17_RS17965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UP17_RS17985	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
UP17_RS17990	COG0247	lactate metabolic process
UP17_RS17995	COG0277	FAD linked oxidase domain protein
UP17_RS18000	COG3835	regulator
UP17_RS18005	COG1620	l-lactate permease
UP17_RS18010	COG2186	Transcriptional regulator
UP17_RS18015	COG0247	lactate metabolic process
UP17_RS18020	COG1139	Iron-sulfur cluster binding protein
UP17_RS18025	COG1556	Lactate utilization protein
UP17_RS18030	COG1363	Peptidase, m42
UP17_RS18050	COG3326	Membrane
UP17_RS18055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UP17_RS18065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UP17_RS18070	COG1247	-acetyltransferase
UP17_RS18075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UP17_RS18085	COG1484	DNA-dependent DNA replication
UP17_RS18090	COG3611	Membrane attachment protein
UP17_RS18095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UP17_RS18100	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
UP17_RS18110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UP17_RS18115	COG0237	dephospho-CoA kinase activity
UP17_RS18120	COG1971	Probably functions as a manganese efflux pump
UP17_RS18125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UP17_RS18130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP17_RS18130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP17_RS18135	COG0330	HflC and HflK could
UP17_RS18140	COG0330	HflC and HflK could
UP17_RS18145	COG5002	protein histidine kinase activity
UP17_RS18150	COG0745	RESPONSE REGULATOR receiver
UP17_RS18160	COG0538	isocitrate dehydrogenase activity
UP17_RS18165	COG0372	Belongs to the citrate synthase family
UP17_RS18170	COG2707	UPF0756 membrane protein
UP17_RS18175	COG0628	permease
UP17_RS18180	COG2224	Isocitrate lyase
UP17_RS18185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
UP17_RS18200	COG0205	6-phosphofructokinase activity
UP17_RS18205	COG0825	malonyl-CoA metabolic process
UP17_RS18210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UP17_RS18215	COG2186	Transcriptional regulator
UP17_RS18220	COG0281	malic enzyme
UP17_RS18225	COG0587	DNA-directed DNA polymerase activity
UP17_RS18240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UP17_RS18250	COG4109	DRTGG domain
UP17_RS18260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UP17_RS18265	COG0006	proline dipeptidase activity
UP17_RS18275	COG0589	response to stress
UP17_RS18280	COG0165	Argininosuccinate lyase
UP17_RS18285	COG0137	argininosuccinate synthase activity
UP17_RS18295	COG0521	Mo-molybdopterin cofactor biosynthetic process
UP17_RS18305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UP17_RS18310	COG0827	DNA restriction-modification system
UP17_RS18315	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
UP17_RS18320	COG3874	Sporulation protein YtfJ
UP17_RS18330	COG1714	RDD family
UP17_RS18335	COG0616	signal peptide processing
UP17_RS18340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UP17_RS18345	COG0084	hydrolase, TatD family'
UP17_RS18355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UP17_RS18365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UP17_RS18380	COG2962	Rard protein
UP17_RS18385	COG1574	metal-dependent hydrolase with the TIM-barrel fold
UP17_RS18390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP17_RS18400	COG0301	tRNA thio-modification
UP17_RS18405	COG1104	cysteine desulfurase activity
UP17_RS18410	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
UP17_RS18415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UP17_RS18420	COG1309	transcriptional regulator
UP17_RS18425	COG1956	GAF domain-containing protein
UP17_RS18430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UP17_RS18445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP17_RS18450	COG0454	-acetyltransferase
UP17_RS18455	COG0517	IMP dehydrogenase activity
UP17_RS18460	COG0123	including yeast histone deacetylase and acetoin utilization protein
UP17_RS18465	COG1609	Transcriptional regulator
UP17_RS18470	COG1605	Chorismate mutase
UP17_RS18470	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
UP17_RS18475	COG3118	belongs to the thioredoxin family
UP17_RS18480	COG4980	gas vesicle protein
UP17_RS18490	COG2309	aminopeptidase activity
UP17_RS18495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UP17_RS18500	COG1674	ftsk spoiiie
UP17_RS18510	COG4848	Belongs to the UPF0354 family
UP17_RS18515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_RS18530	COG2207	Transcriptional regulator
UP17_RS18530	COG3708	Transcriptional regulator
UP17_RS18535	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
UP17_RS18540	COG1363	Peptidase, m42
UP17_RS18550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_RS18555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UP17_RS18565	COG0510	thiamine kinase activity
UP17_RS18585	COG1914	H( )-stimulated, divalent metal cation uptake system
UP17_RS18595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_RS18600	COG0534	Mate efflux family protein
UP17_RS18605	COG0586	Pfam SNARE associated Golgi protein
UP17_RS18620	COG3344	reverse transcriptase
UP17_RS18630	COG3344	reverse transcriptase
UP17_RS18635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UP17_RS18635	COG1587	Uroporphyrinogen-III synthase
UP17_RS18640	COG1587	Uroporphyrinogen-III synthase
UP17_RS18655	COG0039	L-malate dehydrogenase activity
UP17_RS18660	COG1620	l-lactate permease
UP17_RS18665	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UP17_RS18675	COG2814	Major facilitator Superfamily
UP17_RS18685	COG4221	oxidoreductase activity
UP17_RS18695	COG1309	transcriptional regulator
UP17_RS18705	COG0701	Predicted permease
UP17_RS18735	COG2824	Alkylphosphonate utilization operon protein PhnA
UP17_RS18740	COG0745	RESPONSE REGULATOR receiver
UP17_RS18745	COG2205	protein histidine kinase activity
UP17_RS18750	COG1136	(ABC) transporter
UP17_RS18755	COG0577	efflux transmembrane transporter activity
UP17_RS18770	COG1349	DNA-binding transcription factor activity
UP17_RS18775	COG1187	pseudouridine synthase activity
UP17_RS18780	COG2244	polysaccharide biosynthetic process
UP17_RS18785	COG2081	HI0933 family
UP17_RS18800	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS18810	COG0473	3-isopropylmalate dehydrogenase activity
UP17_RS18820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_RS18825	COG1902	pentaerythritol trinitrate reductase activity
UP17_RS18835	COG0656	L-ascorbic acid biosynthetic process
UP17_RS18840	COG2814	Major facilitator Superfamily
UP17_RS18845	COG1733	regulation of RNA biosynthetic process
UP17_RS18860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
UP17_RS18870	COG1647	Serine aminopeptidase, S33
UP17_RS18875	COG1695	Transcriptional regulator
UP17_RS18900	COG1309	transcriptional regulator
UP17_RS18915	COG0720	synthase
UP17_RS18925	COG0840	transmembrane signaling receptor activity
UP17_RS18955	COG4195	phage-related replication protein
UP17_RS18960	COG1388	LysM domain
UP17_RS18960	COG0791	NLP P60 protein
UP17_RS18975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UP17_RS18990	COG2318	DinB family
UP17_RS18995	COG0456	acetyltransferase
UP17_RS19000	COG2002	toxin-antitoxin pair type II binding
UP17_RS19005	COG0697	spore germination
UP17_RS19015	COG2076	Multidrug Resistance protein
UP17_RS19020	COG2076	Multidrug Resistance protein
UP17_RS19025	COG3739	integral membrane protein
UP17_RS19030	COG3655	Transcriptional regulator
UP17_RS19040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP17_RS19050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
UP17_RS19060	COG0697	spore germination
UP17_RS19065	COG0586	Pfam SNARE associated Golgi protein
UP17_RS19070	COG0671	phosphoesterase, PA-phosphatase related
UP17_RS19105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP17_RS19110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UP17_RS19115	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS19120	COG3829	transcription factor binding
UP17_RS19125	COG2801	Transposase and inactivated derivatives
UP17_RS19140	COG2514	catechol 2,3-dioxygenase activity
UP17_RS19145	COG2259	Doxx family
UP17_RS19155	COG0246	Mannitol dehydrogenase
UP17_RS19160	COG3711	transcriptional antiterminator
UP17_RS19165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_RS19165	COG2213	PTS system mannitol-specific
UP17_RS19170	COG2851	Citrate transporter
UP17_RS19175	COG2207	Transcriptional regulator
UP17_RS19180	COG4565	transcriptional regulatory protein
UP17_RS19185	COG3290	protein histidine kinase activity
UP17_RS19195	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
UP17_RS19200	COG2169	Transcriptional regulator
UP17_RS19205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UP17_RS19220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
UP17_RS19230	COG3142	Participates in the control of copper homeostasis
UP17_RS19245	COG0789	Transcriptional regulator
UP17_RS19260	COG1357	PFAM Pentapeptide repeats (8 copies)
UP17_RS19285	COG1823	symporter activity
UP17_RS19310	COG1113	amino acid transport
UP17_RS19345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP17_RS19350	COG0477	Major facilitator Superfamily
UP17_RS19370	COG2197	response regulator
UP17_RS19375	COG4585	Histidine kinase
UP17_RS19400	COG3844	kynureninase activity
UP17_RS19410	COG3483	tryptophan 2,3-dioxygenase activity
UP17_RS19415	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
UP17_RS19420	COG1280	lysine exporter protein (LysE YggA)
UP17_RS19435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_RS19450	COG0778	Nitroreductase
UP17_RS19455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UP17_RS19460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UP17_RS19505	COG2801	Transposase and inactivated derivatives
UP17_RS19515	COG2721	sulfolactate sulfo-lyase activity
UP17_RS19520	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS19525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UP17_RS19530	COG2271	Major facilitator Superfamily
UP17_RS19540	COG2186	Transcriptional regulator
UP17_RS19545	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS19560	COG0583	DNA-binding transcription factor activity
UP17_RS19565	COG1511	domain protein
UP17_RS19570	COG2814	Major facilitator Superfamily
UP17_RS19575	COG1309	transcriptional regulator
UP17_RS19580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP17_RS19585	COG1113	amino acid transport
UP17_RS19595	COG2814	Major facilitator Superfamily
UP17_RS19605	COG1280	lysine exporter protein (LysE YggA)
UP17_RS19610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UP17_RS19630	COG0833	amino acid
UP17_RS19635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_RS19640	COG0183	Belongs to the thiolase family
UP17_RS19645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UP17_RS19650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UP17_RS19655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_RS19660	COG1141	Ferredoxin
UP17_RS19675	COG1509	lysine 2,3-aminomutase activity
UP17_RS19680	COG3829	transcription factor binding
UP17_RS19695	COG1609	Transcriptional regulator
UP17_RS19700	COG0561	phosphatase activity
UP17_RS19705	COG1876	peptidase activity
UP17_RS19715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UP17_RS19720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UP17_RS19725	COG2610	gluconate transmembrane transporter activity
UP17_RS19730	COG3829	transcription factor binding
UP17_RS19730	COG3290	protein histidine kinase activity
UP17_RS19735	COG0183	Belongs to the thiolase family
UP17_RS19740	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP17_RS19745	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_RS19760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UP17_RS19765	COG1846	Transcriptional regulator
UP17_RS19780	COG0024	Methionine aminopeptidase
UP17_RS19785	COG2315	Protein conserved in bacteria
UP17_RS19815	COG3344	reverse transcriptase
UP17_RS19825	COG1876	peptidase activity
UP17_RS19845	COG3011	Protein conserved in bacteria
UP17_RS19850	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP17_RS19905	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UP17_RS19920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UP17_RS19950	COG2031	fatty acid transporter
UP17_RS19970	COG1687	branched-chain amino acid
UP17_RS19975	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
UP17_RS19980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_RS19985	COG1476	TRANSCRIPTIONal
UP17_RS20045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UP17_RS20105	COG5444	nuclease activity
UP17_RS20115	COG2205	protein histidine kinase activity
UP17_RS20140	COG0784	Response regulator, receiver
UP17_RS20145	COG4191	Histidine kinase
UP17_RS20160	COG3973	AAA domain
UP17_RS20185	COG1966	Carbon starvation protein
UP17_RS20190	COG3279	Response regulator of the LytR AlgR family
UP17_RS20195	COG3275	phosphorelay sensor kinase activity
UP17_RS20250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP17_RS20255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UP17_RS20260	COG0346	lactoylglutathione lyase activity
UP17_RS20290	COG2602	Beta-lactamase
UP17_RS20300	COG0659	secondary active sulfate transmembrane transporter activity
UP17_RS20305	COG0288	reversible hydration of carbon dioxide
UP17_RS20315	COG5002	protein histidine kinase activity
UP17_RS20315	COG3850	Histidine kinase
UP17_RS20320	COG0745	RESPONSE REGULATOR receiver
UP17_RS20325	COG0697	spore germination
UP17_RS20335	COG1051	belongs to the nudix hydrolase family
UP17_RS20350	COG1694	Mazg nucleotide pyrophosphohydrolase
UP17_RS20370	COG0412	Dienelactone hydrolase
UP17_RS20390	COG1464	Belongs to the NlpA lipoprotein family
UP17_RS20395	COG2011	ABC-type metal ion transport system permease component
UP17_RS20400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UP17_RS20440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_RS20465	COG0561	phosphatase activity
UP17_RS20485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_RS20490	COG1335	isochorismatase
UP17_RS20505	COG0477	Major facilitator Superfamily
UP17_RS20510	COG1309	transcriptional regulator
UP17_RS20520	COG0583	DNA-binding transcription factor activity
UP17_RS20525	COG0697	spore germination
UP17_RS20530	COG1193	negative regulation of DNA recombination
UP17_RS20535	COG3842	ATPase activity
UP17_RS20545	COG1263	PTS System
UP17_RS20545	COG2190	(PTS) system
UP17_RS20545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_RS20550	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
UP17_RS20575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_RS20600	COG2233	PERMEase
UP17_RS20605	COG0402	S-adenosylhomocysteine deaminase activity
UP17_RS20610	COG0402	S-adenosylhomocysteine deaminase activity
UP17_RS20615	COG0402	S-adenosylhomocysteine deaminase activity
UP17_RS20620	COG0747	negative chemotaxis
UP17_RS20630	COG0402	S-adenosylhomocysteine deaminase activity
UP17_RS20635	COG0747	negative chemotaxis
UP17_RS20640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP17_RS20650	COG0444	Belongs to the ABC transporter superfamily
UP17_RS20655	COG4608	Belongs to the ABC transporter superfamily
UP17_RS20660	COG2972	Histidine kinase
UP17_RS20665	COG2207	Transcriptional regulator
UP17_RS20675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP17_RS20685	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
UP17_RS20745	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_RS20750	COG1522	sequence-specific DNA binding
UP17_RS20755	COG0047	phosphoribosylformylglycinamidine synthase activity
UP17_RS20780	COG1252	NADH dehydrogenase
UP17_RS20785	COG5337	Spore coat protein CotH
UP17_RS20790	COG0018	arginyl-trna synthetase
UP17_RS20795	COG2197	response regulator
UP17_RS20800	COG3239	Fatty acid desaturase
UP17_RS20805	COG3858	chitin binding
UP17_RS20810	COG0697	spore germination
UP17_RS20815	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
UP17_RS20830	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP17_RS20835	COG1131	(ABC) transporter
UP17_RS20850	COG3584	3D domain protein
UP17_RS20850	COG3583	domain protein
UP17_RS20855	COG1247	-acetyltransferase
UP17_RS20865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP17_RS20905	COG1301	dicarboxylic acid transport
UP17_RS20935	COG0583	DNA-binding transcription factor activity
UP17_RS20945	COG3773	Cell wall hydrolase
UP17_RS20950	COG3344	reverse transcriptase
UP17_RS20955	COG1522	sequence-specific DNA binding
UP17_RS20960	COG2357	RelA SpoT domain protein
UP17_RS20980	COG2801	Transposase and inactivated derivatives
UP17_RS20995	COG1522	sequence-specific DNA binding
UP17_RS21000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UP17_RS21005	COG2814	Major facilitator Superfamily
UP17_RS21045	COG0402	S-adenosylhomocysteine deaminase activity
UP17_RS21055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP17_RS21065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_RS21125	COG0822	iron-sulfur transferase activity
UP17_RS21135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UP17_RS21140	COG2072	flavoprotein involved in K transport
UP17_RS21145	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_RS21165	COG3344	reverse transcriptase
UP17_RS21185	COG1595	DNA-templated transcription, initiation
UP17_RS21205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_RS21210	COG0346	lactoylglutathione lyase activity
UP17_RS21235	COG1511	domain protein
UP17_RS21250	COG3655	Transcriptional regulator
UP17_RS21270	COG1464	Belongs to the NlpA lipoprotein family
UP17_RS21275	COG5002	protein histidine kinase activity
UP17_RS21300	COG0671	phosphoesterase, PA-phosphatase related
UP17_RS21310	COG0024	Methionine aminopeptidase
UP17_RS21315	COG2318	DinB family
UP17_RS21385	COG0384	phenazine biosynthesis protein PhzF
UP17_RS21420	COG1114	Component of the transport system for branched-chain amino acids
UP17_RS21430	COG1760	l-serine dehydratase
UP17_RS21435	COG1760	l-serine dehydratase
UP17_RS21455	COG0737	Belongs to the 5'-nucleotidase family
UP17_RS21460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_RS21465	COG0697	spore germination
UP17_RS21470	COG0384	phenazine biosynthesis protein PhzF
UP17_RS21480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP17_RS21490	COG2188	Transcriptional regulator
UP17_RS21505	COG1131	(ABC) transporter
UP17_RS21510	COG1309	transcriptional regulator
UP17_RS21525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UP17_RS21530	COG0569	domain protein
UP17_RS21540	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_RS21545	COG0500	methyltransferase
UP17_RS21545	COG3615	Tellurite resistance protein tehB
UP17_RS21550	COG2226	methyltransferase
UP17_RS21555	COG2226	methyltransferase
UP17_RS21575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UP17_RS21580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP17_RS21585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP17_RS21590	COG2910	NAD(P)H-binding
UP17_RS21595	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
UP17_RS21605	COG1959	2 iron, 2 sulfur cluster binding
UP17_RS21610	COG4193	domain, Protein
UP17_RS21615	COG2112	serine threonine protein kinase
UP17_RS21625	COG3832	glyoxalase III activity
UP17_RS21630	COG0640	Transcriptional regulator
UP17_RS21635	COG1511	domain protein
UP17_RS21640	COG1959	2 iron, 2 sulfur cluster binding
UP17_RS21645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_RS21660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UP17_RS21665	COG4122	O-methyltransferase activity
UP17_RS21695	COG0346	lactoylglutathione lyase activity
UP17_RS21700	COG1846	Transcriptional regulator
UP17_RS21705	COG2814	Major facilitator Superfamily
UP17_RS21720	COG1131	(ABC) transporter
UP17_RS21740	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UP17_RS21740	COG0456	acetyltransferase
UP17_RS21750	COG2197	response regulator
UP17_RS21760	COG0586	Pfam SNARE associated Golgi protein
UP17_RS21765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UP17_RS21775	COG0726	polysaccharide deacetylase
UP17_RS21780	COG5002	protein histidine kinase activity
UP17_RS21780	COG3850	Histidine kinase
UP17_RS21785	COG0745	RESPONSE REGULATOR receiver
UP17_RS21805	COG0725	ABC transporter, periplasmic molybdate-binding protein
UP17_RS21810	COG1910	domain protein
UP17_RS21815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UP17_RS21830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UP17_RS21835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_RS21850	COG3104	oligopeptide transport
UP17_RS21865	COG1595	DNA-templated transcription, initiation
UP17_RS21870	COG0726	polysaccharide deacetylase
UP17_RS21885	COG4302	ethanolamine ammonia-lyase activity
UP17_RS21890	COG4303	Ethanolamine ammonia lyase large subunit
UP17_RS21895	COG4819	ethanolamine utilization protein
UP17_RS21925	COG4548	von Willebrand factor, type A
UP17_RS21930	COG0714	Associated with various cellular activities
UP17_RS21935	COG1114	Component of the transport system for branched-chain amino acids
UP17_RS21940	COG0110	maltose O-acetyltransferase activity
UP17_RS21945	COG0702	epimerase
UP17_RS21950	COG5566	PFAM Mor transcription activator
UP17_RS21970	COG0493	'glutamate synthase
UP17_RS21975	COG0069	glutamate synthase activity
UP17_RS21975	COG0067	glutamate synthase
UP17_RS21975	COG0070	glutamate synthase
UP17_RS21980	COG0583	DNA-binding transcription factor activity
UP17_RS21985	COG5577	PFAM Coat F domain
UP17_RS22000	COG1404	Belongs to the peptidase S8 family
UP17_RS22005	COG0495	leucyl-tRNA aminoacylation
UP17_RS22020	COG1242	4 iron, 4 sulfur cluster binding
UP17_RS22025	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
UP17_RS22035	COG2267	carboxylic ester hydrolase activity
UP17_RS22040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
UP17_RS22045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UP17_RS22070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UP17_RS22100	COG1683	Conserved Protein
UP17_RS22110	COG1506	peptidase
UP17_RS22115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UP17_RS22120	COG1116	anion transmembrane transporter activity
UP17_RS22125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UP17_RS22145	COG0783	Belongs to the Dps family
UP17_RS22150	COG1854	S-ribosylhomocysteine lyase activity
UP17_RS22155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UP17_RS22165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UP17_RS22170	COG3290	protein histidine kinase activity
UP17_RS22175	COG4565	transcriptional regulatory protein
UP17_RS22180	COG4948	Mandelate Racemase Muconate Lactonizing
UP17_RS22185	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_RS22190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
UP17_RS22200	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
UP17_RS22205	COG1169	isochorismate synthase
UP17_RS22210	COG1575	Belongs to the MenA family. Type 1 subfamily
UP17_RS22215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP17_RS22350	COG1285	pathogenesis
UP17_RS22365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_RS22390	COG0506	proline dehydrogenase activity
UP17_RS22395	COG1012	belongs to the aldehyde dehydrogenase family
UP17_RS22400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_RS22405	COG2508	Transcriptional regulator
UP17_RS22410	COG1959	2 iron, 2 sulfur cluster binding
UP17_RS22415	COG5553	Cysteine dioxygenase type I
UP17_RS22420	COG2368	4-hydroxyphenylacetate
UP17_RS22425	COG1309	transcriptional regulator
UP17_RS22430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_RS22435	COG1115	amino acid carrier protein
UP17_RS22440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UP17_RS22450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UP17_RS22455	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
UP17_RS22465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UP17_RS22470	COG0640	Transcriptional regulator
UP17_RS22475	COG2814	Major facilitator Superfamily
UP17_RS22480	COG1994	Peptidase M50
UP17_RS22485	COG0833	amino acid
UP17_RS22505	COG1472	Belongs to the glycosyl hydrolase 3 family
UP17_RS22515	COG1378	Sugar-specific transcriptional regulator TrmB
UP17_RS22530	COG3344	reverse transcriptase
UP17_RS22535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UP17_RS22540	COG0604	alcohol dehydrogenase
UP17_RS22545	COG4191	Histidine kinase
UP17_RS22550	COG3773	Cell wall hydrolase
UP17_RS22555	COG3906	Belongs to the UPF0473 family
UP17_RS22560	COG1595	DNA-templated transcription, initiation
UP17_RS22570	COG0346	lactoylglutathione lyase activity
UP17_RS22575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UP17_RS22585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UP17_RS22590	COG0523	cobalamin synthesis protein
UP17_RS22595	COG0322	excinuclease ABC activity
UP17_RS22605	COG1785	Belongs to the alkaline phosphatase family
UP17_RS22615	COG3344	reverse transcriptase
UP17_RS22620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
UP17_RS22630	COG0753	catalase activity
UP17_RS22640	COG1950	PFAM Membrane protein of
UP17_RS22645	COG0640	Transcriptional regulator
UP17_RS22650	COG2814	Major facilitator Superfamily
UP17_RS22660	COG1113	amino acid transport
UP17_RS22670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
UP17_RS22685	COG0697	spore germination
UP17_RS22690	COG0737	Belongs to the 5'-nucleotidase family
UP17_RS22695	COG2318	DinB family
UP17_RS22700	COG0456	acetyltransferase
UP17_RS22705	COG1191	sigma factor activity
UP17_RS22740	COG2814	Major facilitator Superfamily
UP17_RS22745	COG0531	amino acid
UP17_RS22750	COG1968	undecaprenyl-diphosphatase activity
UP17_RS22755	COG0584	glycerophosphoryl diester phosphodiesterase
UP17_RS22765	COG1388	LysM domain
UP17_RS22765	COG3858	chitin binding
UP17_RS22770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UP17_RS22785	COG1979	alcohol dehydrogenase
UP17_RS22790	COG2155	Conserved Protein
UP17_RS22795	COG1098	S1 RNA binding domain
UP17_RS22800	COG0733	neurotransmitter:sodium symporter activity
UP17_RS22810	COG0436	Aminotransferase
UP17_RS22815	COG1522	sequence-specific DNA binding
UP17_RS22820	COG2267	carboxylic ester hydrolase activity
UP17_RS22830	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UP17_RS22835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP17_RS22850	COG0456	acetyltransferase
UP17_RS22860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UP17_RS22870	COG5018	Exonuclease
UP17_RS22885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UP17_RS22885	COG2111	Na H antiporter
UP17_RS22890	COG2111	Na H antiporter
UP17_RS22895	COG1006	Multisubunit Na H antiporter MnhC subunit
UP17_RS22900	COG0651	ATP synthesis coupled electron transport
UP17_RS22905	COG1863	multisubunit Na H antiporter MnhE subunit
UP17_RS22910	COG2212	antiporter activity
UP17_RS22915	COG1320	monovalent cation:proton antiporter activity
UP17_RS22925	COG2050	protein possibly involved in aromatic compounds catabolism
UP17_RS22940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP17_RS22940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP17_RS22945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP17_RS22945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP17_RS22955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UP17_RS22960	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
UP17_RS22970	COG3584	3D domain protein
UP17_RS22975	COG3344	reverse transcriptase
UP17_RS22990	COG1252	NADH dehydrogenase
UP17_RS22995	COG0492	ferredoxin-NADP+ reductase activity
UP17_RS23000	COG0316	Belongs to the HesB IscA family
UP17_RS23015	COG1252	NADH dehydrogenase
UP17_RS23020	COG4837	Protein of unknown function (DUF1462)
UP17_RS23025	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
UP17_RS23030	COG0083	homoserine kinase activity
UP17_RS23035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UP17_RS23040	COG0460	homoserine dehydrogenase
UP17_RS23050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP17_RS23055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UP17_RS23060	COG0647	UMP catabolic process
UP17_RS23065	COG2445	Protein of unknown function DUF86
UP17_RS23080	COG4470	Protein conserved in bacteria
UP17_RS23090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UP17_RS23095	COG0739	heme binding
UP17_RS23105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
UP17_RS23110	COG3377	Domain of unknown function (DUF1805)
UP17_RS23115	COG0737	Belongs to the 5'-nucleotidase family
UP17_RS23120	COG0730	response to heat
UP17_RS23125	COG1801	Protein of unknown function DUF72
UP17_RS23130	COG0719	Fe-S assembly protein
UP17_RS23135	COG0822	iron-sulfur transferase activity
UP17_RS23140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UP17_RS23145	COG0719	Fe-S assembly protein
UP17_RS23150	COG0396	ATPase activity
UP17_RS23155	COG1464	Belongs to the NlpA lipoprotein family
UP17_RS23160	COG2011	ABC-type metal ion transport system permease component
UP17_RS23165	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UP17_RS23170	COG2873	o-acetylhomoserine
UP17_RS23175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_RS23180	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
UP17_RS23185	COG0509	glycine decarboxylation via glycine cleavage system
UP17_RS23190	COG1393	Belongs to the ArsC family
UP17_RS23195	COG1960	acyl-CoA dehydrogenase activity
UP17_RS23200	COG0183	Belongs to the thiolase family
UP17_RS23205	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP17_RS23205	COG1024	Enoyl-CoA hydratase
UP17_RS23220	COG5577	PFAM Coat F domain
UP17_RS23225	COG0772	Belongs to the SEDS family
UP17_RS23230	COG1609	Transcriptional regulator
UP17_RS23235	COG0833	amino acid
UP17_RS23240	COG0366	Alpha amylase catalytic
UP17_RS23280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
UP17_RS23285	COG1368	sulfuric ester hydrolase activity
UP17_RS23290	COG4607	ABC-type enterochelin transport system periplasmic component
UP17_RS23295	COG4604	ABC transporter, ATP-binding protein
UP17_RS23300	COG4605	iron ion homeostasis
UP17_RS23305	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_RS23320	COG1657	PFAM Prenyltransferase squalene oxidase
UP17_RS23335	COG3850	Histidine kinase
UP17_RS23335	COG5002	protein histidine kinase activity
UP17_RS23340	COG0745	RESPONSE REGULATOR receiver
UP17_RS23345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP17_RS23350	COG2197	response regulator
UP17_RS23355	COG4585	Histidine kinase
UP17_RS23360	COG3239	Fatty acid desaturase
UP17_RS23370	COG3290	protein histidine kinase activity
UP17_RS23395	COG0583	DNA-binding transcription factor activity
UP17_RS23400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UP17_RS23405	COG5609	conserved protein (DUF2294)
UP17_RS23410	COG3383	formate dehydrogenase (NAD+) activity
UP17_RS23415	COG2427	Protein of unknown function (DUF1641)
UP17_RS23440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UP17_RS23445	COG0557	exoribonuclease II activity
UP17_RS23450	COG1647	Serine aminopeptidase, S33
UP17_RS23455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UP17_RS23465	COG1876	peptidase activity
UP17_RS23475	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
UP17_RS23480	COG0149	triose-phosphate isomerase activity
UP17_RS23485	COG0126	phosphoglycerate kinase activity
UP17_RS23490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UP17_RS23505	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UP17_RS23515	COG0740	serine-type endopeptidase activity
UP17_RS23520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_RS23530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
UP17_RS23535	COG1660	Displays ATPase and GTPase activities
UP17_RS23540	COG1051	belongs to the nudix hydrolase family
UP17_RS23545	COG0492	ferredoxin-NADP+ reductase activity
UP17_RS23550	COG0457	Tetratricopeptide repeat
UP17_RS23555	COG0140	phosphoribosyl-ATP diphosphatase activity
UP17_RS23555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UP17_RS23560	COG0107	imidazoleglycerol-phosphate synthase activity
UP17_RS23565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UP17_RS23570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UP17_RS23575	COG0131	Imidazoleglycerol-phosphate dehydratase
UP17_RS23580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UP17_RS23585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UP17_RS23590	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
UP17_RS23600	COG3764	Sortase (surface protein transpeptidase)
UP17_RS23605	COG0110	maltose O-acetyltransferase activity
UP17_RS23610	COG0546	phosphoglycolate phosphatase activity
UP17_RS23615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
UP17_RS23620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UP17_RS23630	COG3595	metallopeptidase activity
UP17_RS23635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UP17_RS23640	COG0556	nucleotide-excision repair
UP17_RS23645	COG4897	Protein conserved in bacteria
UP17_RS23650	COG0753	catalase activity
UP17_RS23660	COG2353	YceI-like domain
UP17_RS23665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_RS23670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_RS23675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP17_RS23680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP17_RS23685	COG3409	Peptidoglycan-binding domain 1 protein
UP17_RS23685	COG0793	Belongs to the peptidase S41A family
UP17_RS23690	COG0791	NLP P60 protein
UP17_RS23690	COG3883	PFAM NLP P60 protein
UP17_RS23695	COG2177	Part of the ABC transporter FtsEX involved in
UP17_RS23700	COG2884	Cell division ATP-binding protein ftsE
UP17_RS23715	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UP17_RS23720	COG0653	protein targeting
UP17_RS23725	COG1396	sequence-specific DNA binding
UP17_RS23730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
UP17_RS23740	COG1516	flagellar protein fliS
UP17_RS23745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
UP17_RS23750	COG1334	flagellar protein FlaG
UP17_RS23760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
UP17_RS23765	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
UP17_RS23775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP17_RS23780	COG1256	bacterial-type flagellum assembly
UP17_RS23780	COG4786	Flagellar basal body rod
UP17_RS23790	COG2747	anti-sigma28 factor FlgM
UP17_RS23805	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
UP17_RS23810	COG1307	EDD domain protein, DegV family
UP17_RS23815	COG2197	response regulator
UP17_RS23820	COG4585	Histidine kinase
UP17_RS23825	COG1739	Uncharacterized protein family UPF0029
UP17_RS23830	COG1316	TRANSCRIPTIONal
UP17_RS23835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UP17_RS23855	COG0728	peptidoglycan biosynthetic process
UP17_RS23860	COG0438	transferase activity, transferring glycosyl groups
UP17_RS23865	COG1134	teichoic acid transport
UP17_RS23870	COG1682	transport, permease protein
UP17_RS23875	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP17_RS23885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP17_RS23890	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UP17_RS23895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP17_RS23900	COG1388	LysM domain
UP17_RS23900	COG0791	NLP P60 protein
UP17_RS23905	COG1316	TRANSCRIPTIONal
UP17_RS23910	COG1368	sulfuric ester hydrolase activity
UP17_RS23925	COG0653	protein targeting
UP17_RS23930	COG1785	Belongs to the alkaline phosphatase family
UP17_RS23935	COG2247	cell wall binding repeat
UP17_RS23935	COG2385	sporulation resulting in formation of a cellular spore
UP17_RS23945	COG0768	penicillin binding
UP17_RS23965	COG4715	Zinc finger, swim domain protein
UP17_RS23970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP17_RS23975	COG1279	arginine transmembrane transporter activity
UP17_RS23980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_RS23995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP17_RS24000	COG0601	transmembrane transport
UP17_RS24005	COG0747	negative chemotaxis
UP17_RS24010	COG4608	Belongs to the ABC transporter superfamily
UP17_RS24015	COG0444	Belongs to the ABC transporter superfamily
UP17_RS24025	COG0629	single-stranded DNA binding
UP17_RS24050	COG4786	Flagellar basal body rod
UP17_RS24055	COG4786	Flagellar basal body rod
UP17_RS24060	COG1077	Cell shape determining protein MreB Mrl
UP17_RS24065	COG1609	Transcriptional regulator
UP17_RS24070	COG0739	heme binding
UP17_RS24080	COG2385	sporulation resulting in formation of a cellular spore
UP17_RS24095	COG4836	Membrane
UP17_RS24100	COG1007	ATP synthesis coupled electron transport
UP17_RS24105	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_RS24110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UP17_RS24115	COG0713	ATP synthesis coupled electron transport
UP17_RS24125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_RS24135	COG0649	NAD binding
UP17_RS24140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_RS24145	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_RS24150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_RS24160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UP17_RS24165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UP17_RS24175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UP17_RS24185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UP17_RS24190	COG0356	it plays a direct role in the translocation of protons across the membrane
UP17_RS24200	COG1404	Belongs to the peptidase S8 family
UP17_RS24205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UP17_RS24210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UP17_RS24225	COG0698	ribose 5-phosphate isomerase
UP17_RS24240	COG1971	Probably functions as a manganese efflux pump
UP17_RS24245	COG0009	L-threonylcarbamoyladenylate synthase
UP17_RS24260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UP17_RS24270	COG1435	thymidine kinase activity
UP17_RS24280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UP17_RS24285	COG1494	fructose-1,6-bisphosphatase
UP17_RS24290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UP17_RS24295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UP17_RS24305	COG2204	response regulator
UP17_RS24310	COG4821	SIS domain
UP17_RS24315	COG0504	CTP synthase activity
UP17_RS24320	COG3343	RNA polymerase activity
UP17_RS24325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS24325	COG1703	isobutyryl-CoA mutase activity
UP17_RS24325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_RS24335	COG1960	acyl-CoA dehydrogenase activity
UP17_RS24340	COG1960	acyl-CoA dehydrogenase activity
UP17_RS24345	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP17_RS24350	COG0183	Belongs to the thiolase family
UP17_RS24355	COG2181	nitrate reductase activity
UP17_RS24355	COG0247	lactate metabolic process
UP17_RS24360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_RS24370	COG0018	arginyl-trna synthetase
UP17_RS24380	COG0010	Belongs to the arginase family
UP17_RS24385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UP17_RS24390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP17_RS24400	COG1994	Peptidase M50
UP17_RS24410	COG3465	dGTPase activity
UP17_RS24415	COG1078	dGTPase activity
UP17_RS24420	COG4844	belongs to the
UP17_RS24435	COG0280	phosphate acetyltransferase
UP17_RS24440	COG3253	May function as heme-dependent peroxidase
UP17_RS24450	COG2363	Small membrane protein
UP17_RS24460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UP17_RS24475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UP17_RS24480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
UP17_RS24485	COG0314	molybdopterin synthase activity
UP17_RS24490	COG0746	molybdenum cofactor guanylyltransferase activity
UP17_RS24495	COG0351	phosphomethylpyrimidine kinase
UP17_RS24500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP17_RS24510	COG2814	Major facilitator Superfamily
UP17_RS24515	COG1846	Transcriptional regulator
UP17_RS24525	COG0561	phosphatase activity
UP17_RS24535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UP17_RS24560	COG2096	Adenosyltransferase
UP17_RS24575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
UP17_RS24585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UP17_RS24590	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
UP17_RS24595	COG1120	ATPase activity
UP17_RS24600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_RS24605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP17_RS24610	COG0726	polysaccharide deacetylase
UP17_RS24620	COG3397	chitin binding
UP17_RS24625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP17_RS24635	COG0551	DNA topoisomerase type I activity
UP17_RS24635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UP17_RS24640	COG0488	(ABC) transporter
UP17_RS24650	COG3173	Aminoglycoside phosphotransferase
UP17_RS24660	COG2252	PERMEase
UP17_RS24685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UP17_RS24685	COG0723	plastoquinol--plastocyanin reductase activity
UP17_RS24690	COG4895	conserved protein (DUF2196)
UP17_RS24700	COG0788	formyltetrahydrofolate deformylase activity
UP17_RS24705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP17_RS24710	COG0765	amino acid transport
UP17_RS24720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UP17_RS24725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP17_RS24725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP17_RS24730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
UP17_RS24735	COG5002	protein histidine kinase activity
UP17_RS24740	COG0745	RESPONSE REGULATOR receiver
UP17_RS24755	COG3162	membrane
UP17_RS24760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_RS24775	COG2267	carboxylic ester hydrolase activity
UP17_RS24780	COG1301	dicarboxylic acid transport
UP17_RS24790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
UP17_RS24800	COG0583	DNA-binding transcription factor activity
UP17_RS24805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP17_RS24810	COG1869	D-ribose catabolic process
UP17_RS24815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP17_RS24845	COG0076	glutamate decarboxylase activity
UP17_RS24860	COG2195	Cleaves the N-terminal amino acid of tripeptides
UP17_RS24865	COG0753	catalase activity
UP17_RS24865	COG0693	protein deglycase activity
UP17_RS24875	COG2329	Antibiotic biosynthesis monooxygenase
UP17_RS24880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UP17_RS24885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
UP17_RS24890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP17_RS24895	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
UP17_RS24900	COG4853	Protein conserved in bacteria
UP17_RS24910	COG5002	protein histidine kinase activity
UP17_RS24915	COG0745	RESPONSE REGULATOR receiver
UP17_RS24920	COG0741	lytic transglycosylase activity
UP17_RS24920	COG1196	nuclear chromosome segregation
UP17_RS24920	COG0739	heme binding
UP17_RS24950	COG0305	Participates in initiation and elongation during chromosome replication
UP17_RS24955	COG0359	binds to the 23S rRNA
UP17_RS24960	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
UP17_RS24970	COG3344	reverse transcriptase
UP17_RS24975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UP17_RS24980	COG0629	single-stranded DNA binding
UP17_RS24985	COG0360	Binds together with S18 to 16S ribosomal RNA
UP17_RS24990	COG0012	GTP binding
UP17_RS24995	COG4481	Protein conserved in bacteria
UP17_RS25000	COG0668	transmembrane transport
UP17_RS25015	COG1475	DNA binding
UP17_RS25020	COG1192	Involved in chromosome partitioning
UP17_RS25025	COG1475	DNA binding
UP17_RS25030	COG0357	Ribosomal RNA small subunit methyltransferase G
UP17_RS25035	COG0445	tRNA wobble uridine modification
UP17_RS25045	COG3344	reverse transcriptase
UP17_RS25050	COG1847	R3H domain protein
UP17_RS25055	COG0706	membrane insertase activity
UP17_RS25060	COG0594	ribonuclease P activity
UP17_RS25110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UP17_RS25255	COG0470	DNA polymerase III