locus-tag	class	description
BSM4216_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BSM4216_RS00010	COG0592	DNA-directed DNA polymerase activity
BSM4216_RS00015	COG2501	S4 domain
BSM4216_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BSM4216_RS00030	COG0187	DNA topoisomerase II activity
BSM4216_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BSM4216_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BSM4216_RS00065	COG0516	GMP reductase activity
BSM4216_RS00065	COG0517	IMP dehydrogenase activity
BSM4216_RS00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BSM4216_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BSM4216_RS00085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BSM4216_RS00095	COG1388	LysM domain
BSM4216_RS00095	COG3858	chitin binding
BSM4216_RS00100	COG0590	tRNA wobble adenosine to inosine editing
BSM4216_RS00105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BSM4216_RS00110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BSM4216_RS00115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BSM4216_RS00150	COG1982	Orn Lys Arg decarboxylase major
BSM4216_RS00155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BSM4216_RS00160	COG1728	Protein conserved in bacteria
BSM4216_RS00165	COG0470	DNA polymerase III
BSM4216_RS00170	COG1774	PSP1 C-terminal conserved region
BSM4216_RS00175	COG4467	Involved in initiation control of chromosome replication
BSM4216_RS00180	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BSM4216_RS00185	COG2827	Endonuclease containing a URI domain
BSM4216_RS00190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BSM4216_RS00195	COG2002	toxin-antitoxin pair type II binding
BSM4216_RS00205	COG0084	hydrolase, TatD family'
BSM4216_RS00210	COG3583	domain protein
BSM4216_RS00210	COG3584	3D domain protein
BSM4216_RS00220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BSM4216_RS00230	COG4466	Protein conserved in bacteria
BSM4216_RS00245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BSM4216_RS00250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSM4216_RS00255	COG0251	oxidation-reduction process
BSM4216_RS00260	COG2088	sporulation resulting in formation of a cellular spore
BSM4216_RS00265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BSM4216_RS00275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BSM4216_RS00290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BSM4216_RS00295	COG2002	toxin-antitoxin pair type II binding
BSM4216_RS00300	COG2244	polysaccharide biosynthetic process
BSM4216_RS00305	COG3956	TIGRFAM MazG family protein
BSM4216_RS00310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BSM4216_RS00325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BSM4216_RS00330	COG1098	S1 RNA binding domain
BSM4216_RS00340	COG2208	phosphoserine phosphatase activity
BSM4216_RS00345	COG2304	oxidoreductase activity
BSM4216_RS00350	COG0515	serine threonine protein kinase
BSM4216_RS00360	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BSM4216_RS00365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BSM4216_RS00370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BSM4216_RS00375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BSM4216_RS00380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSM4216_RS00385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BSM4216_RS00390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BSM4216_RS00395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BSM4216_RS00400	COG1396	sequence-specific DNA binding
BSM4216_RS00405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BSM4216_RS00495	COG3880	PFAM UvrB UvrC protein
BSM4216_RS00500	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BSM4216_RS00505	COG0542	response to heat
BSM4216_RS00510	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BSM4216_RS00520	COG4956	integral membrane protein (PIN domain superfamily)
BSM4216_RS00525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BSM4216_RS00530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BSM4216_RS00535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSM4216_RS00540	COG1045	serine acetyltransferase
BSM4216_RS00545	COG0215	cysteine-tRNA ligase activity
BSM4216_RS00550	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BSM4216_RS00555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSM4216_RS00560	COG3688	RNA-binding protein containing a PIN domain
BSM4216_RS00570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BSM4216_RS00575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BSM4216_RS00580	COG0250	Participates in transcription elongation, termination and antitermination
BSM4216_RS00585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BSM4216_RS00590	COG0081	regulation of translation
BSM4216_RS00600	COG0222	ribosome binding
BSM4216_RS00605	COG2813	Specifically methylates the guanine in position
BSM4216_RS00610	COG0085	RNA polymerase activity
BSM4216_RS00615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BSM4216_RS00620	COG1358	cellular component organization or biogenesis
BSM4216_RS00625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BSM4216_RS00630	COG0049	tRNA binding
BSM4216_RS00635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BSM4216_RS00640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BSM4216_RS00645	COG0051	transcription antitermination factor activity, RNA binding
BSM4216_RS00650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BSM4216_RS00655	COG0088	Forms part of the polypeptide exit tunnel
BSM4216_RS00660	COG0089	rRNA binding
BSM4216_RS00665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BSM4216_RS00670	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BSM4216_RS00675	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BSM4216_RS00680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BSM4216_RS00685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BSM4216_RS00690	COG0255	Belongs to the universal ribosomal protein uL29 family
BSM4216_RS00695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BSM4216_RS00700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BSM4216_RS00710	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BSM4216_RS00715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BSM4216_RS00720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BSM4216_RS00725	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BSM4216_RS00730	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BSM4216_RS00735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BSM4216_RS00740	COG1841	ribosomal large subunit assembly
BSM4216_RS00745	COG0200	Binds to the 23S rRNA
BSM4216_RS00750	COG0201	protein transport
BSM4216_RS00755	COG0563	adenylate kinase activity
BSM4216_RS00760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BSM4216_RS00765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BSM4216_RS00770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BSM4216_RS00775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BSM4216_RS00780	COG0202	RNA polymerase activity
BSM4216_RS00785	COG0203	ribosomal protein L17
BSM4216_RS00790	COG1122	ATPase activity
BSM4216_RS00795	COG1122	ATPase activity
BSM4216_RS00800	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BSM4216_RS00805	COG0101	tRNA pseudouridine synthase activity
BSM4216_RS00810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BSM4216_RS00815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BSM4216_RS00825	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSM4216_RS00830	COG0489	protein tyrosine kinase activity
BSM4216_RS00840	COG2194	sulfuric ester hydrolase activity
BSM4216_RS00845	COG0726	polysaccharide deacetylase
BSM4216_RS00925	COG1595	DNA-templated transcription, initiation
BSM4216_RS00930	COG5662	AntiSigma factor
BSM4216_RS00935	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BSM4216_RS00940	COG4856	YbbR-like protein
BSM4216_RS00945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSM4216_RS00950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BSM4216_RS00970	COG3973	AAA domain
BSM4216_RS00980	COG0346	lactoylglutathione lyase activity
BSM4216_RS00990	COG1819	glycosyl
BSM4216_RS00995	COG1247	-acetyltransferase
BSM4216_RS01010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_RS01015	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS01020	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS01030	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS01035	COG0500	methyltransferase
BSM4216_RS01055	COG2814	Major facilitator Superfamily
BSM4216_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_RS01105	COG4948	Mandelate Racemase Muconate Lactonizing
BSM4216_RS01115	COG0789	Transcriptional regulator
BSM4216_RS01125	COG2080	2 iron, 2 sulfur cluster binding
BSM4216_RS01170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BSM4216_RS01175	COG0022	dehydrogenase e1 component
BSM4216_RS01185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BSM4216_RS01210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_RS01215	COG4521	taurine ABC transporter
BSM4216_RS01225	COG2175	clavaminate synthase activity
BSM4216_RS01230	COG2076	Multidrug Resistance protein
BSM4216_RS01255	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BSM4216_RS01300	COG0515	serine threonine protein kinase
BSM4216_RS01300	COG2815	serine threonine protein kinase
BSM4216_RS01305	COG2205	protein histidine kinase activity
BSM4216_RS01310	COG0745	RESPONSE REGULATOR receiver
BSM4216_RS01320	COG2814	Major facilitator Superfamily
BSM4216_RS01330	COG1664	Polymer-forming cytoskeletal
BSM4216_RS01335	COG0789	Transcriptional regulator
BSM4216_RS01355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_RS01370	COG1335	isochorismatase
BSM4216_RS01390	COG3414	Phosphotransferase system galactitol-specific IIB component
BSM4216_RS01395	COG3775	system Galactitol-specific IIC component
BSM4216_RS01400	COG1063	alcohol dehydrogenase
BSM4216_RS01410	COG1063	alcohol dehydrogenase
BSM4216_RS01415	COG1349	DNA-binding transcription factor activity
BSM4216_RS01425	COG1070	Carbohydrate kinase
BSM4216_RS01430	COG4806	L-rhamnose isomerase
BSM4216_RS01435	COG0235	Class ii aldolase
BSM4216_RS01440	COG3254	rhamnose metabolic process
BSM4216_RS01445	COG2814	Major facilitator Superfamily
BSM4216_RS01450	COG0697	spore germination
BSM4216_RS01455	COG0204	Acyl-transferase
BSM4216_RS01470	COG0789	Transcriptional regulator
BSM4216_RS01480	COG2323	membrane
BSM4216_RS01485	COG0702	epimerase
BSM4216_RS01495	COG1361	Conserved repeat domain
BSM4216_RS01500	COG1404	Belongs to the peptidase S8 family
BSM4216_RS01515	COG0475	glutathione-regulated potassium exporter activity
BSM4216_RS01520	COG0527	aspartate kinase activity
BSM4216_RS01540	COG0693	protein deglycase activity
BSM4216_RS01545	COG3835	regulator
BSM4216_RS01550	COG0277	FAD linked oxidase domain protein
BSM4216_RS01555	COG0247	lactate metabolic process
BSM4216_RS01565	COG3655	Transcriptional regulator
BSM4216_RS01570	COG3739	integral membrane protein
BSM4216_RS01635	COG1011	Hydrolase
BSM4216_RS01650	COG4177	L-phenylalanine transmembrane transporter activity
BSM4216_RS01655	COG0411	ABC transporter
BSM4216_RS01680	COG2353	YceI-like domain
BSM4216_RS01690	COG1737	Transcriptional regulator
BSM4216_RS01695	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BSM4216_RS01700	COG1268	BioY protein
BSM4216_RS01705	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_RS01710	COG0183	Belongs to the thiolase family
BSM4216_RS01715	COG4989	oxidoreductase activity
BSM4216_RS01720	COG0604	alcohol dehydrogenase
BSM4216_RS01765	COG1131	(ABC) transporter
BSM4216_RS01770	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BSM4216_RS01790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BSM4216_RS01795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BSM4216_RS01800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BSM4216_RS01815	COG0730	response to heat
BSM4216_RS01825	COG1609	Transcriptional regulator
BSM4216_RS01840	COG0235	Class ii aldolase
BSM4216_RS01845	COG2160	L-arabinose isomerase activity
BSM4216_RS01850	COG2433	Pfam Transposase IS66
BSM4216_RS01930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BSM4216_RS01935	COG3344	reverse transcriptase
BSM4216_RS01945	COG1297	OPT oligopeptide transporter protein
BSM4216_RS01960	COG3584	3D domain protein
BSM4216_RS01960	COG1388	LysM domain
BSM4216_RS01965	COG3584	3D domain protein
BSM4216_RS01965	COG1388	LysM domain
BSM4216_RS01970	COG2814	Major facilitator Superfamily
BSM4216_RS01985	COG0768	penicillin binding
BSM4216_RS01990	COG0791	NLP P60 protein
BSM4216_RS01990	COG1388	LysM domain
BSM4216_RS02000	COG3344	reverse transcriptase
BSM4216_RS02010	COG0653	protein targeting
BSM4216_RS02015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BSM4216_RS02020	COG1316	TRANSCRIPTIONal
BSM4216_RS02025	COG1739	Uncharacterized protein family UPF0029
BSM4216_RS02030	COG4585	Histidine kinase
BSM4216_RS02035	COG2197	response regulator
BSM4216_RS02040	COG2188	Transcriptional regulator
BSM4216_RS02045	COG0366	Alpha amylase catalytic
BSM4216_RS02050	COG1263	PTS System
BSM4216_RS02050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_RS02055	COG1307	EDD domain protein, DegV family
BSM4216_RS02065	COG1040	competence protein
BSM4216_RS02085	COG4786	Flagellar basal body rod
BSM4216_RS02085	COG1256	bacterial-type flagellum assembly
BSM4216_RS02090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSM4216_RS02100	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BSM4216_RS02105	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BSM4216_RS02125	COG1334	flagellar protein FlaG
BSM4216_RS02130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BSM4216_RS02135	COG1516	flagellar protein fliS
BSM4216_RS02155	COG0653	protein targeting
BSM4216_RS02160	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BSM4216_RS02170	COG0745	RESPONSE REGULATOR receiver
BSM4216_RS02175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BSM4216_RS02195	COG3344	reverse transcriptase
BSM4216_RS02200	COG2884	Cell division ATP-binding protein ftsE
BSM4216_RS02205	COG2177	Part of the ABC transporter FtsEX involved in
BSM4216_RS02210	COG0791	NLP P60 protein
BSM4216_RS02210	COG3883	PFAM NLP P60 protein
BSM4216_RS02215	COG3328	transposase activity
BSM4216_RS02220	COG0456	acetyltransferase
BSM4216_RS02230	COG0793	Belongs to the peptidase S41A family
BSM4216_RS02230	COG3409	Peptidoglycan-binding domain 1 protein
BSM4216_RS02235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSM4216_RS02255	COG0697	spore germination
BSM4216_RS02265	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BSM4216_RS02270	COG0556	nucleotide-excision repair
BSM4216_RS02275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BSM4216_RS02280	COG0363	glucosamine-6-phosphate deaminase activity
BSM4216_RS02285	COG2188	Transcriptional regulator
BSM4216_RS02290	COG1263	PTS System
BSM4216_RS02290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_RS02290	COG2190	(PTS) system
BSM4216_RS02295	COG1609	Transcriptional regulator
BSM4216_RS02300	COG1983	PspC domain protein
BSM4216_RS02305	COG1950	PFAM Membrane protein of
BSM4216_RS02310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BSM4216_RS02315	COG0671	phosphoesterase, PA-phosphatase related
BSM4216_RS02320	COG0586	Pfam SNARE associated Golgi protein
BSM4216_RS02335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BSM4216_RS02340	COG0546	phosphoglycolate phosphatase activity
BSM4216_RS02345	COG0110	maltose O-acetyltransferase activity
BSM4216_RS02350	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BSM4216_RS02355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BSM4216_RS02360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BSM4216_RS02365	COG0131	Imidazoleglycerol-phosphate dehydratase
BSM4216_RS02370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BSM4216_RS02375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BSM4216_RS02380	COG0107	imidazoleglycerol-phosphate synthase activity
BSM4216_RS02385	COG0140	phosphoribosyl-ATP diphosphatase activity
BSM4216_RS02385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BSM4216_RS02390	COG0457	Tetratricopeptide repeat
BSM4216_RS02395	COG0492	ferredoxin-NADP+ reductase activity
BSM4216_RS02400	COG1051	belongs to the nudix hydrolase family
BSM4216_RS02405	COG1660	Displays ATPase and GTPase activities
BSM4216_RS02410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BSM4216_RS02415	COG1481	regulation of sporulation
BSM4216_RS02420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSM4216_RS02425	COG0740	serine-type endopeptidase activity
BSM4216_RS02435	COG2258	MOSC domain
BSM4216_RS02450	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BSM4216_RS02470	COG0126	phosphoglycerate kinase activity
BSM4216_RS02475	COG0149	triose-phosphate isomerase activity
BSM4216_RS02485	COG0148	phosphopyruvate hydratase activity
BSM4216_RS02490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BSM4216_RS02495	COG1647	Serine aminopeptidase, S33
BSM4216_RS02500	COG0557	exoribonuclease II activity
BSM4216_RS02505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BSM4216_RS02510	COG3226	Transcriptional regulator
BSM4216_RS02530	COG0583	DNA-binding transcription factor activity
BSM4216_RS02540	COG1988	membrane-bound metal-dependent
BSM4216_RS02545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BSM4216_RS02550	COG0022	dehydrogenase e1 component
BSM4216_RS02555	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSM4216_RS02560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSM4216_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_RS02575	COG3284	Transcriptional regulator
BSM4216_RS02600	COG3706	GGDEF domain
BSM4216_RS02605	COG0673	inositol 2-dehydrogenase activity
BSM4216_RS02620	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BSM4216_RS02625	COG0840	transmembrane signaling receptor activity
BSM4216_RS02655	COG2204	response regulator
BSM4216_RS02660	COG5002	protein histidine kinase activity
BSM4216_RS02670	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BSM4216_RS02675	COG2079	MmgE PrpD family protein
BSM4216_RS02685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BSM4216_RS02690	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BSM4216_RS02695	COG1733	regulation of RNA biosynthetic process
BSM4216_RS02700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BSM4216_RS02705	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BSM4216_RS02730	COG0482	sulfurtransferase activity
BSM4216_RS02745	COG0535	radical SAM domain protein
BSM4216_RS02765	COG4464	protein tyrosine phosphatase activity
BSM4216_RS02770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSM4216_RS02775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSM4216_RS02780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BSM4216_RS02790	COG0840	transmembrane signaling receptor activity
BSM4216_RS02795	COG1316	TRANSCRIPTIONal
BSM4216_RS02810	COG2358	TRAP transporter, solute receptor (TAXI family
BSM4216_RS02820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSM4216_RS02825	COG2022	thiamine diphosphate biosynthetic process
BSM4216_RS02830	COG2104	thiamine diphosphate biosynthetic process
BSM4216_RS02835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSM4216_RS02840	COG0352	thiamine-phosphate diphosphorylase activity
BSM4216_RS02845	COG4512	PFAM Accessory gene regulator B
BSM4216_RS02865	COG3852	Histidine kinase
BSM4216_RS02870	COG0531	amino acid
BSM4216_RS02880	COG1522	sequence-specific DNA binding
BSM4216_RS02885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BSM4216_RS02890	COG1984	allophanate hydrolase subunit 2
BSM4216_RS02895	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BSM4216_RS02905	COG1113	amino acid transport
BSM4216_RS02910	COG3689	TIGRFAM TIGR03943 family protein
BSM4216_RS02915	COG0701	Predicted permease
BSM4216_RS02920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_RS02925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_RS02930	COG1116	anion transmembrane transporter activity
BSM4216_RS02940	COG0833	amino acid
BSM4216_RS02955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BSM4216_RS02970	COG1215	transferase activity, transferring glycosyl groups
BSM4216_RS02980	COG0824	Thioesterase
BSM4216_RS02985	COG0431	NADPH-dependent FMN reductase
BSM4216_RS02990	COG4106	trans-aconitate 2-methyltransferase activity
BSM4216_RS02995	COG1349	DNA-binding transcription factor activity
BSM4216_RS03000	COG1105	Belongs to the carbohydrate kinase PfkB family
BSM4216_RS03005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSM4216_RS03005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSM4216_RS03005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSM4216_RS03010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BSM4216_RS03010	COG0551	DNA topoisomerase type I activity
BSM4216_RS03015	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BSM4216_RS03020	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BSM4216_RS03065	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_RS03070	COG2244	polysaccharide biosynthetic process
BSM4216_RS03085	COG0288	reversible hydration of carbon dioxide
BSM4216_RS03090	COG1410	methionine synthase
BSM4216_RS03090	COG0646	methionine synthase
BSM4216_RS03095	COG0646	methionine synthase
BSM4216_RS03095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BSM4216_RS03100	COG1077	Cell shape determining protein MreB Mrl
BSM4216_RS03105	COG1607	acyl-coa hydrolase
BSM4216_RS03110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BSM4216_RS03115	COG0493	'glutamate synthase
BSM4216_RS03120	COG0070	glutamate synthase
BSM4216_RS03120	COG0069	glutamate synthase activity
BSM4216_RS03120	COG0067	glutamate synthase
BSM4216_RS03125	COG0583	DNA-binding transcription factor activity
BSM4216_RS03130	COG2309	aminopeptidase activity
BSM4216_RS03135	COG3189	MarR family transcriptional regulator
BSM4216_RS03140	COG1959	2 iron, 2 sulfur cluster binding
BSM4216_RS03150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSM4216_RS03165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BSM4216_RS03170	COG1360	Flagellar Motor Protein
BSM4216_RS03175	COG0693	protein deglycase activity
BSM4216_RS03180	COG0024	Methionine aminopeptidase
BSM4216_RS03185	COG4840	Belongs to the UPF0435 family
BSM4216_RS03190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BSM4216_RS03195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BSM4216_RS03205	COG2217	Heavy metal translocating P-type atpase
BSM4216_RS03210	COG0387	Pfam Sodium calcium exchanger
BSM4216_RS03240	COG3093	addiction module antidote protein HigA
BSM4216_RS03275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSM4216_RS03280	COG1136	(ABC) transporter
BSM4216_RS03285	COG0577	efflux transmembrane transporter activity
BSM4216_RS03295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSM4216_RS03300	COG5001	Diguanylate cyclase
BSM4216_RS03300	COG5002	protein histidine kinase activity
BSM4216_RS03315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BSM4216_RS03320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BSM4216_RS03345	COG1988	membrane-bound metal-dependent
BSM4216_RS03350	COG1194	a g-specific adenine glycosylase
BSM4216_RS03360	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_RS03375	COG3557	Belongs to the UPF0374 family
BSM4216_RS03385	COG1132	(ABC) transporter
BSM4216_RS03390	COG4129	membrane
BSM4216_RS03395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BSM4216_RS03405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BSM4216_RS03415	COG2096	Adenosyltransferase
BSM4216_RS03420	COG0735	belongs to the Fur family
BSM4216_RS03530	COG0583	DNA-binding transcription factor activity
BSM4216_RS03535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_RS03540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_RS03545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BSM4216_RS03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_RS03555	COG0765	amino acid transport
BSM4216_RS03560	COG0765	amino acid transport
BSM4216_RS03565	COG1126	abc transporter atp-binding protein
BSM4216_RS03575	COG1473	amidohydrolase
BSM4216_RS03595	COG3328	transposase activity
BSM4216_RS03610	COG1113	amino acid transport
BSM4216_RS03620	COG2211	Major facilitator Superfamily
BSM4216_RS03625	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BSM4216_RS03630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BSM4216_RS03640	COG2808	Putative FMN-binding domain
BSM4216_RS03645	COG1280	lysine exporter protein (LysE YggA)
BSM4216_RS03650	COG0531	amino acid
BSM4216_RS03660	COG1247	-acetyltransferase
BSM4216_RS03680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BSM4216_RS03695	COG0778	Nitroreductase
BSM4216_RS03705	COG2766	serine protein kinase
BSM4216_RS03735	COG1086	Polysaccharide biosynthesis protein
BSM4216_RS03740	COG2718	Belongs to the UPF0229 family
BSM4216_RS03745	COG3402	PFAM membrane-flanked domain
BSM4216_RS03760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSM4216_RS03770	COG2323	membrane
BSM4216_RS03780	COG3104	oligopeptide transport
BSM4216_RS03790	COG2252	PERMEase
BSM4216_RS03795	COG0306	phosphate transporter
BSM4216_RS03800	COG1392	Phosphate transport regulator
BSM4216_RS03805	COG0656	L-ascorbic acid biosynthetic process
BSM4216_RS03810	COG0564	pseudouridine synthase activity
BSM4216_RS03830	COG2719	SpoVR family
BSM4216_RS03835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSM4216_RS03840	COG0390	transport system, permease component
BSM4216_RS03865	COG1414	Transcriptional regulator
BSM4216_RS03880	COG3971	2-oxopent-4-enoate hydratase activity
BSM4216_RS03905	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BSM4216_RS03910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSM4216_RS03915	COG0725	ABC transporter, periplasmic molybdate-binding protein
BSM4216_RS03920	COG4149	molybdate abc transporter
BSM4216_RS03925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSM4216_RS03935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BSM4216_RS03940	COG0129	dihydroxy-acid dehydratase activity
BSM4216_RS03945	COG0028	Belongs to the TPP enzyme family
BSM4216_RS03950	COG0440	acetolactate synthase activity
BSM4216_RS03955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BSM4216_RS03960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSM4216_RS03970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BSM4216_RS03975	COG0066	3-isopropylmalate dehydratase activity
BSM4216_RS03980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BSM4216_RS03985	COG0512	Glutamine amidotransferase of anthranilate synthase
BSM4216_RS03990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BSM4216_RS04010	COG0189	ligase activity
BSM4216_RS04015	COG0189	ligase activity
BSM4216_RS04020	COG0189	ligase activity
BSM4216_RS04030	COG4399	Belongs to the UPF0754 family
BSM4216_RS04035	COG3679	Belongs to the UPF0342 family
BSM4216_RS04060	COG0561	phosphatase activity
BSM4216_RS04065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BSM4216_RS04080	COG0420	3'-5' exonuclease activity
BSM4216_RS04085	COG4717	serine-type aminopeptidase activity
BSM4216_RS04090	COG3481	metal-dependent phosphohydrolase, HD sub domain
BSM4216_RS04100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSM4216_RS04125	COG1846	Transcriptional regulator
BSM4216_RS04145	COG0537	adenosine 5'-monophosphoramidase activity
BSM4216_RS04150	COG1131	(ABC) transporter
BSM4216_RS04155	COG4473	ABC transporter
BSM4216_RS04160	COG3069	C4-dicarboxylate transmembrane transporter activity
BSM4216_RS04165	COG2329	Antibiotic biosynthesis monooxygenase
BSM4216_RS04170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BSM4216_RS04175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BSM4216_RS04180	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BSM4216_RS04185	COG1309	transcriptional regulator
BSM4216_RS04190	COG1511	domain protein
BSM4216_RS04195	COG1234	tRNA 3'-trailer cleavage
BSM4216_RS04200	COG0492	ferredoxin-NADP+ reductase activity
BSM4216_RS04210	COG1024	Enoyl-CoA hydratase
BSM4216_RS04220	COG0501	Belongs to the peptidase M48B family
BSM4216_RS04225	COG5582	Belongs to the UPF0302 family
BSM4216_RS04230	COG4903	ComK protein
BSM4216_RS04240	COG0398	Pfam SNARE associated Golgi protein
BSM4216_RS04260	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BSM4216_RS04265	COG1074	ATP-dependent DNA helicase activity
BSM4216_RS04300	COG2311	Membrane
BSM4216_RS04305	COG0179	Fumarylacetoacetate (FAA) hydrolase
BSM4216_RS04320	COG0367	asparagine synthase
BSM4216_RS04340	COG1666	GTP binding
BSM4216_RS04345	COG1307	EDD domain protein, DegV family
BSM4216_RS04350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSM4216_RS04355	COG1073	alpha beta
BSM4216_RS04360	COG2151	metal-sulfur cluster biosynthetic enzyme
BSM4216_RS04370	COG0542	response to heat
BSM4216_RS04380	COG2267	carboxylic ester hydrolase activity
BSM4216_RS04390	COG1744	ABC transporter substrate-binding protein PnrA-like
BSM4216_RS04405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSM4216_RS04410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BSM4216_RS04420	COG2197	response regulator
BSM4216_RS04425	COG1131	(ABC) transporter
BSM4216_RS04440	COG5504	Zn-dependent protease
BSM4216_RS04455	COG0180	Tryptophanyl-tRNA synthetase
BSM4216_RS04470	COG4166	transmembrane transport
BSM4216_RS04475	COG0601	transmembrane transport
BSM4216_RS04480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSM4216_RS04485	COG0444	Belongs to the ABC transporter superfamily
BSM4216_RS04490	COG4608	Belongs to the ABC transporter superfamily
BSM4216_RS04505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_RS04510	COG0765	amino acid transport
BSM4216_RS04515	COG0765	amino acid transport
BSM4216_RS04520	COG1393	Belongs to the ArsC family
BSM4216_RS04525	COG5002	protein histidine kinase activity
BSM4216_RS04535	COG0573	inorganic phosphate transmembrane transporter activity
BSM4216_RS04540	COG0581	inorganic phosphate transmembrane transporter activity
BSM4216_RS04550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSM4216_RS04555	COG0704	Plays a role in the regulation of phosphate uptake
BSM4216_RS04560	COG1349	DNA-binding transcription factor activity
BSM4216_RS04565	COG1276	copper resistance
BSM4216_RS04565	COG2372	response to copper ion
BSM4216_RS04570	COG4549	nuclear export factor GLE1
BSM4216_RS04580	COG4862	establishment of competence for transformation
BSM4216_RS04590	COG1164	Oligoendopeptidase f
BSM4216_RS04600	COG3853	Toxic anion resistance protein (TelA)
BSM4216_RS04605	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BSM4216_RS04610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BSM4216_RS04615	COG2346	COG2346, Truncated hemoglobins
BSM4216_RS04620	COG0741	lytic transglycosylase activity
BSM4216_RS04625	COG4116	CYTH
BSM4216_RS04635	COG2357	RelA SpoT domain protein
BSM4216_RS04645	COG0564	pseudouridine synthase activity
BSM4216_RS04650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BSM4216_RS04715	COG2153	protein acetylation
BSM4216_RS04720	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BSM4216_RS04725	COG2382	esterase
BSM4216_RS04740	COG1063	alcohol dehydrogenase
BSM4216_RS04765	COG0386	Belongs to the glutathione peroxidase family
BSM4216_RS04770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSM4216_RS04800	COG0431	NADPH-dependent FMN reductase
BSM4216_RS04815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_RS04820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_RS04850	COG1247	-acetyltransferase
BSM4216_RS04870	COG0531	amino acid
BSM4216_RS04890	COG0579	oxidoreductase
BSM4216_RS04910	COG0535	radical SAM domain protein
BSM4216_RS04920	COG1131	(ABC) transporter
BSM4216_RS04925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BSM4216_RS04935	COG0612	Peptidase, M16
BSM4216_RS04945	COG1959	2 iron, 2 sulfur cluster binding
BSM4216_RS04950	COG2910	NAD(P)H-binding
BSM4216_RS04955	COG1125	glycine betaine transport
BSM4216_RS04955	COG0517	IMP dehydrogenase activity
BSM4216_RS04960	COG1732	Glycine betaine
BSM4216_RS04990	COG0446	pyridine nucleotide-disulphide oxidoreductase
BSM4216_RS04990	COG1902	pentaerythritol trinitrate reductase activity
BSM4216_RS04995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BSM4216_RS05005	COG2318	DinB family
BSM4216_RS05010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BSM4216_RS05015	COG2814	Major facilitator Superfamily
BSM4216_RS05025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BSM4216_RS05040	COG1131	(ABC) transporter
BSM4216_RS05050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BSM4216_RS05060	COG0523	cobalamin synthesis protein
BSM4216_RS05065	COG2814	Major facilitator Superfamily
BSM4216_RS05070	COG0196	riboflavin kinase activity
BSM4216_RS05075	COG5583	Uncharacterized small protein (DUF2292)
BSM4216_RS05080	COG0778	Nitroreductase
BSM4216_RS05085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSM4216_RS05090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BSM4216_RS05095	COG0561	phosphatase activity
BSM4216_RS05100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BSM4216_RS05105	COG0803	Belongs to the bacterial solute-binding protein 9 family
BSM4216_RS05110	COG1121	(ABC) transporter
BSM4216_RS05115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BSM4216_RS05125	COG0701	Predicted permease
BSM4216_RS05135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSM4216_RS05140	COG3162	membrane
BSM4216_RS05155	COG0076	glutamate decarboxylase activity
BSM4216_RS05185	COG1120	ATPase activity
BSM4216_RS05190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSM4216_RS05195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSM4216_RS05200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSM4216_RS05210	COG1120	ATPase activity
BSM4216_RS05215	COG0778	Nitroreductase
BSM4216_RS05220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSM4216_RS05225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSM4216_RS05230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSM4216_RS05250	COG1082	Xylose isomerase domain protein TIM barrel
BSM4216_RS05265	COG2259	Doxx family
BSM4216_RS05270	COG0346	lactoylglutathione lyase activity
BSM4216_RS05275	COG0400	carboxylic ester hydrolase activity
BSM4216_RS05280	COG2514	catechol 2,3-dioxygenase activity
BSM4216_RS05285	COG1914	H( )-stimulated, divalent metal cation uptake system
BSM4216_RS05295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSM4216_RS05305	COG0463	Glycosyl transferase, family 2
BSM4216_RS05310	COG2246	polysaccharide biosynthetic process
BSM4216_RS05315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSM4216_RS05335	COG2135	peptidase activity
BSM4216_RS05345	COG1937	Protein conserved in bacteria
BSM4216_RS05355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BSM4216_RS05360	COG0720	synthase
BSM4216_RS05365	COG0602	queuosine metabolic process
BSM4216_RS05370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BSM4216_RS05395	COG3328	transposase activity
BSM4216_RS05405	COG1473	amidohydrolase
BSM4216_RS05410	COG4948	Mandelate Racemase Muconate Lactonizing
BSM4216_RS05420	COG3764	Sortase (surface protein transpeptidase)
BSM4216_RS05455	COG3383	formate dehydrogenase (NAD+) activity
BSM4216_RS05465	COG0753	catalase activity
BSM4216_RS05470	COG1126	abc transporter atp-binding protein
BSM4216_RS05475	COG0765	amino acid transport
BSM4216_RS05480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_RS05495	COG0626	cystathionine gamma-synthase activity
BSM4216_RS05500	COG0626	cystathionine gamma-synthase activity
BSM4216_RS05505	COG2261	transglycosylase associated protein
BSM4216_RS05510	COG1363	Peptidase, m42
BSM4216_RS05520	COG2233	PERMEase
BSM4216_RS05525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BSM4216_RS05535	COG0861	Integral membrane protein TerC family
BSM4216_RS05545	COG1032	radical SAM domain protein
BSM4216_RS05550	COG3594	Acyltransferase
BSM4216_RS05555	COG5002	protein histidine kinase activity
BSM4216_RS05560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BSM4216_RS05570	COG3852	Histidine kinase
BSM4216_RS05575	COG1846	Transcriptional regulator
BSM4216_RS05580	COG0542	response to heat
BSM4216_RS05585	COG3949	Membrane
BSM4216_RS05595	COG4873	Protein conserved in bacteria
BSM4216_RS05610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BSM4216_RS05615	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_RS05620	COG2084	Dehydrogenase
BSM4216_RS05625	COG0436	Aminotransferase
BSM4216_RS05630	COG0598	Magnesium transport protein CorA
BSM4216_RS05635	COG0784	Response regulator, receiver
BSM4216_RS05635	COG0835	chemotaxis
BSM4216_RS05650	COG0156	8-amino-7-oxononanoate synthase activity
BSM4216_RS05655	COG0596	Alpha beta hydrolase
BSM4216_RS05665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_RS05670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_RS05675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_RS05680	COG1116	anion transmembrane transporter activity
BSM4216_RS05685	COG0431	NADPH-dependent FMN reductase
BSM4216_RS05690	COG2855	membrane
BSM4216_RS05700	COG1408	metallophosphoesterase
BSM4216_RS05710	COG2200	EAL domain
BSM4216_RS05720	COG4703	Protein of unknown function (DUF1797)
BSM4216_RS05725	COG0517	IMP dehydrogenase activity
BSM4216_RS05730	COG2814	Major facilitator Superfamily
BSM4216_RS05735	COG0583	DNA-binding transcription factor activity
BSM4216_RS05740	COG2171	N-acyltransferase activity
BSM4216_RS05745	COG1473	amidohydrolase
BSM4216_RS05750	COG0450	alkyl hydroperoxide reductase
BSM4216_RS05755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_RS05765	COG1271	oxidase subunit
BSM4216_RS05770	COG1294	oxidase, subunit
BSM4216_RS05775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BSM4216_RS05780	COG5503	Protein of unknown function (DUF1447)
BSM4216_RS05785	COG0561	phosphatase activity
BSM4216_RS05825	COG1982	Orn Lys Arg decarboxylase major
BSM4216_RS05835	COG4476	Belongs to the UPF0223 family
BSM4216_RS05840	COG4493	Belongs to the UPF0637 family
BSM4216_RS05855	COG0483	inositol monophosphate 1-phosphatase activity
BSM4216_RS05865	COG1217	gtp-binding protein TYPA
BSM4216_RS05885	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BSM4216_RS05890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BSM4216_RS05900	COG0772	Belongs to the SEDS family
BSM4216_RS05905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BSM4216_RS05910	COG1612	heme a metabolic process
BSM4216_RS05915	COG0109	protoheme IX farnesyltransferase activity
BSM4216_RS05940	COG3336	cytochrome c oxidase
BSM4216_RS05960	COG2340	Cysteine-rich secretory protein family
BSM4216_RS05965	COG2050	protein possibly involved in aromatic compounds catabolism
BSM4216_RS05985	COG3679	Belongs to the UPF0342 family
BSM4216_RS05990	COG4471	UPF0298 protein
BSM4216_RS06000	COG0742	ribosomal rna small subunit methyltransferase
BSM4216_RS06005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BSM4216_RS06010	COG3314	Sporulation integral membrane protein YlbJ
BSM4216_RS06015	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSM4216_RS06020	COG3480	Lon protease (S16) C-terminal proteolytic domain
BSM4216_RS06025	COG1323	Belongs to the UPF0348 family
BSM4216_RS06030	COG1399	metal-binding, possibly nucleic acid-binding protein
BSM4216_RS06035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BSM4216_RS06045	COG0454	-acetyltransferase
BSM4216_RS06050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BSM4216_RS06055	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BSM4216_RS06065	COG0275	rRNA processing
BSM4216_RS06070	COG4839	cell division protein FtsL
BSM4216_RS06075	COG0768	penicillin binding
BSM4216_RS06080	COG0768	penicillin binding
BSM4216_RS06085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BSM4216_RS06095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BSM4216_RS06100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BSM4216_RS06105	COG0772	Belongs to the SEDS family
BSM4216_RS06110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BSM4216_RS06115	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BSM4216_RS06120	COG0849	cell division
BSM4216_RS06125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BSM4216_RS06135	COG1191	sigma factor activity
BSM4216_RS06140	COG1191	sigma factor activity
BSM4216_RS06145	COG1873	PFAM PRC-barrel domain
BSM4216_RS06155	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BSM4216_RS06160	COG1799	cell septum assembly
BSM4216_RS06165	COG0762	integral membrane protein
BSM4216_RS06170	COG2302	S4 RNA-binding domain
BSM4216_RS06175	COG3599	regulation of cell shape
BSM4216_RS06180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BSM4216_RS06190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BSM4216_RS06195	COG0564	pseudouridine synthase activity
BSM4216_RS06200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BSM4216_RS06210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BSM4216_RS06230	COG0167	dihydroorotate dehydrogenase activity
BSM4216_RS06235	COG0284	orotidine-5'-phosphate decarboxylase activity
BSM4216_RS06240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BSM4216_RS06250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BSM4216_RS06255	COG1561	YicC-like family, N-terminal region
BSM4216_RS06260	COG2052	Domain of unknown function (DUF370)
BSM4216_RS06265	COG0194	GDP metabolic process
BSM4216_RS06275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BSM4216_RS06280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BSM4216_RS06285	COG0242	peptide deformylase activity
BSM4216_RS06290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BSM4216_RS06295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BSM4216_RS06295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSM4216_RS06305	COG0631	protein serine/threonine phosphatase activity
BSM4216_RS06310	COG2815	serine threonine protein kinase
BSM4216_RS06310	COG0515	serine threonine protein kinase
BSM4216_RS06315	COG1162	GTPase activity
BSM4216_RS06320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BSM4216_RS06325	COG1564	THIamine pyrophosphokinase
BSM4216_RS06335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BSM4216_RS06340	COG1302	Protein conserved in bacteria
BSM4216_RS06345	COG1461	Dihydroxyacetone kinase
BSM4216_RS06350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BSM4216_RS06355	COG1349	DNA-binding transcription factor activity
BSM4216_RS06360	COG0416	fatty acid biosynthetic process
BSM4216_RS06365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BSM4216_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_RS06375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BSM4216_RS06380	COG0571	ribonuclease III activity
BSM4216_RS06385	COG1196	nuclear chromosome segregation
BSM4216_RS06390	COG0552	protein localization to endoplasmic reticulum
BSM4216_RS06395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BSM4216_RS06400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BSM4216_RS06405	COG0228	four-way junction DNA binding
BSM4216_RS06415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BSM4216_RS06420	COG0336	Belongs to the RNA methyltransferase TrmD family
BSM4216_RS06425	COG0335	large ribosomal subunit rRNA binding
BSM4216_RS06435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BSM4216_RS06440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BSM4216_RS06450	COG2257	FlhB HrpN YscU SpaS Family
BSM4216_RS06455	COG0045	succinate-CoA ligase (ADP-forming) activity
BSM4216_RS06460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BSM4216_RS06465	COG0758	DNA mediated transformation
BSM4216_RS06470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BSM4216_RS06475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BSM4216_RS06480	COG4974	Belongs to the 'phage' integrase family
BSM4216_RS06485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BSM4216_RS06490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BSM4216_RS06495	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BSM4216_RS06500	COG1815	bacterial-type flagellum-dependent cell motility
BSM4216_RS06505	COG1558	bacterial-type flagellum-dependent cell motility
BSM4216_RS06510	COG1677	Flagellar hook-basal body complex protein FliE
BSM4216_RS06515	COG1766	The M ring may be actively involved in energy transduction
BSM4216_RS06520	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSM4216_RS06530	COG1157	protein secretion by the type III secretion system
BSM4216_RS06535	COG2882	bacterial-type flagellum organization
BSM4216_RS06550	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BSM4216_RS06555	COG4786	Flagellar basal body rod
BSM4216_RS06560	COG1582	Flagellar protein (FlbD)
BSM4216_RS06565	COG1580	Controls the rotational direction of flagella during chemotaxis
BSM4216_RS06570	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSM4216_RS06575	COG1776	CheC inhibitor of MCP methylation
BSM4216_RS06575	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSM4216_RS06580	COG2201	protein-glutamate methylesterase activity
BSM4216_RS06585	COG3190	flagellar
BSM4216_RS06590	COG1338	Plays a role in the flagellum-specific transport system
BSM4216_RS06595	COG1987	bacterial-type flagellum assembly
BSM4216_RS06600	COG1684	flagellar biosynthetic protein fliR
BSM4216_RS06605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BSM4216_RS06610	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BSM4216_RS06615	COG1419	protein localization to endoplasmic reticulum
BSM4216_RS06620	COG0455	bacterial-type flagellum organization
BSM4216_RS06625	COG2201	protein-glutamate methylesterase activity
BSM4216_RS06630	COG2198	Histidine kinase
BSM4216_RS06630	COG0643	Histidine kinase
BSM4216_RS06635	COG0835	chemotaxis
BSM4216_RS06640	COG1776	CheC inhibitor of MCP methylation
BSM4216_RS06645	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BSM4216_RS06650	COG1191	sigma factor activity
BSM4216_RS06660	COG0052	Belongs to the universal ribosomal protein uS2 family
BSM4216_RS06665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BSM4216_RS06670	COG0528	UMP kinase activity
BSM4216_RS06675	COG0233	cytoplasmic translational termination
BSM4216_RS06685	COG4589	Belongs to the CDS family
BSM4216_RS06690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BSM4216_RS06695	COG0750	zinc metalloprotease
BSM4216_RS06700	COG0442	prolyl-tRNA aminoacylation
BSM4216_RS06705	COG2176	DNA-directed DNA polymerase activity
BSM4216_RS06710	COG0779	Required for maturation of 30S ribosomal subunits
BSM4216_RS06715	COG0195	Participates in both transcription termination and antitermination
BSM4216_RS06720	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BSM4216_RS06725	COG1358	cellular component organization or biogenesis
BSM4216_RS06730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BSM4216_RS06735	COG1550	Protein conserved in bacteria
BSM4216_RS06740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BSM4216_RS06745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BSM4216_RS06750	COG0196	riboflavin kinase activity
BSM4216_RS06755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BSM4216_RS06760	COG1185	polyribonucleotide nucleotidyltransferase activity
BSM4216_RS06765	COG0726	polysaccharide deacetylase
BSM4216_RS06770	COG0612	Peptidase, M16
BSM4216_RS06780	COG1268	BioY protein
BSM4216_RS06785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BSM4216_RS06800	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_RS06805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BSM4216_RS06810	COG0303	'Molybdopterin
BSM4216_RS06815	COG1763	Mo-molybdopterin cofactor biosynthetic process
BSM4216_RS06830	COG1346	cytolysis
BSM4216_RS06845	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_RS06855	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSM4216_RS06875	COG2045	Belongs to the ComB family
BSM4216_RS06880	COG1024	Enoyl-CoA hydratase
BSM4216_RS06885	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_RS06895	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_RS06900	COG4191	Histidine kinase
BSM4216_RS06905	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS06910	COG0071	Belongs to the small heat shock protein (HSP20) family
BSM4216_RS06915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BSM4216_RS06925	COG2223	nitrite transmembrane transporter activity
BSM4216_RS06930	COG2391	methyltransferase activity
BSM4216_RS06940	COG4637	Psort location Cytoplasmic, score
BSM4216_RS06945	COG2814	Major facilitator Superfamily
BSM4216_RS06950	COG1272	protein, Hemolysin III
BSM4216_RS06960	COG0024	Methionine aminopeptidase
BSM4216_RS06970	COG0531	amino acid
BSM4216_RS06985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSM4216_RS06985	COG0723	plastoquinol--plastocyanin reductase activity
BSM4216_RS07010	COG0295	cytidine deaminase activity
BSM4216_RS07015	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BSM4216_RS07020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSM4216_RS07045	COG5337	Spore coat protein CotH
BSM4216_RS07060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSM4216_RS07065	COG1733	regulation of RNA biosynthetic process
BSM4216_RS07085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BSM4216_RS07090	COG1113	amino acid transport
BSM4216_RS07095	COG1280	lysine exporter protein (LysE YggA)
BSM4216_RS07105	COG0243	molybdopterin cofactor binding
BSM4216_RS07115	COG1587	Uroporphyrinogen-III synthase
BSM4216_RS07125	COG3328	transposase activity
BSM4216_RS07130	COG0477	Major facilitator Superfamily
BSM4216_RS07140	COG0534	Mate efflux family protein
BSM4216_RS07150	COG0840	transmembrane signaling receptor activity
BSM4216_RS07150	COG3290	protein histidine kinase activity
BSM4216_RS07155	COG2427	Protein of unknown function (DUF1641)
BSM4216_RS07160	COG3383	formate dehydrogenase (NAD+) activity
BSM4216_RS07165	COG5609	conserved protein (DUF2294)
BSM4216_RS07170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BSM4216_RS07175	COG2116	formate transmembrane transporter activity
BSM4216_RS07185	COG3773	Cell wall hydrolase
BSM4216_RS07195	COG0708	Exodeoxyribonuclease III
BSM4216_RS07200	COG1741	Belongs to the pirin family
BSM4216_RS07210	COG2066	Belongs to the glutaminase family
BSM4216_RS07215	COG2070	2-Nitropropane dioxygenase
BSM4216_RS07225	COG1122	ATPase activity
BSM4216_RS07235	COG0640	Transcriptional regulator
BSM4216_RS07240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BSM4216_RS07245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BSM4216_RS07255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSM4216_RS07260	COG0384	phenazine biosynthesis protein PhzF
BSM4216_RS07265	COG1279	arginine transmembrane transporter activity
BSM4216_RS07270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BSM4216_RS07275	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSM4216_RS07285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BSM4216_RS07290	COG1937	Protein conserved in bacteria
BSM4216_RS07295	COG2217	Heavy metal translocating P-type atpase
BSM4216_RS07305	COG0702	epimerase
BSM4216_RS07315	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS07330	COG2267	carboxylic ester hydrolase activity
BSM4216_RS07335	COG3832	glyoxalase III activity
BSM4216_RS07340	COG0640	Transcriptional regulator
BSM4216_RS07345	COG3290	protein histidine kinase activity
BSM4216_RS07345	COG0840	transmembrane signaling receptor activity
BSM4216_RS07355	COG2226	methyltransferase
BSM4216_RS07360	COG1854	S-ribosylhomocysteine lyase activity
BSM4216_RS07365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSM4216_RS07370	COG0626	cystathionine gamma-synthase activity
BSM4216_RS07380	COG1129	ABC transporter
BSM4216_RS07385	COG1172	Belongs to the binding-protein-dependent transport system permease family
BSM4216_RS07395	COG1609	Transcriptional regulator
BSM4216_RS07400	COG0673	inositol 2-dehydrogenase activity
BSM4216_RS07415	COG3962	Belongs to the TPP enzyme family
BSM4216_RS07420	COG1082	Xylose isomerase domain protein TIM barrel
BSM4216_RS07425	COG3718	enzyme involved in inositol metabolism
BSM4216_RS07430	COG2814	Major facilitator Superfamily
BSM4216_RS07435	COG0673	inositol 2-dehydrogenase activity
BSM4216_RS07450	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_RS07455	COG2030	dehydratase
BSM4216_RS07470	COG0456	acetyltransferase
BSM4216_RS07545	COG1011	Hydrolase
BSM4216_RS07560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSM4216_RS07565	COG0444	Belongs to the ABC transporter superfamily
BSM4216_RS07570	COG4608	Belongs to the ABC transporter superfamily
BSM4216_RS07580	COG1464	Belongs to the NlpA lipoprotein family
BSM4216_RS07585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BSM4216_RS07590	COG2011	ABC-type metal ion transport system permease component
BSM4216_RS07595	COG1464	Belongs to the NlpA lipoprotein family
BSM4216_RS07600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_RS07610	COG3328	transposase activity
BSM4216_RS07615	COG0454	-acetyltransferase
BSM4216_RS07670	COG0697	spore germination
BSM4216_RS07695	COG1607	acyl-coa hydrolase
BSM4216_RS07700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BSM4216_RS07705	COG0531	amino acid
BSM4216_RS07710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSM4216_RS07720	COG2376	Dihydroxyacetone kinase
BSM4216_RS07725	COG1461	Dihydroxyacetone kinase
BSM4216_RS07730	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BSM4216_RS07735	COG1113	amino acid transport
BSM4216_RS07745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BSM4216_RS07765	COG2205	protein histidine kinase activity
BSM4216_RS07770	COG1136	(ABC) transporter
BSM4216_RS07775	COG0577	efflux transmembrane transporter activity
BSM4216_RS07795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSM4216_RS07805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BSM4216_RS07810	COG0488	(ABC) transporter
BSM4216_RS07815	COG0583	DNA-binding transcription factor activity
BSM4216_RS07820	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_RS07840	COG4372	Transposase
BSM4216_RS07850	COG1611	Belongs to the LOG family
BSM4216_RS07865	COG0515	serine threonine protein kinase
BSM4216_RS07870	COG0730	response to heat
BSM4216_RS07875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BSM4216_RS07875	COG1648	precorrin-2 dehydrogenase activity
BSM4216_RS07895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BSM4216_RS07900	COG0529	Catalyzes the synthesis of activated sulfate
BSM4216_RS07905	COG2046	Belongs to the sulfate adenylyltransferase family
BSM4216_RS07910	COG0175	sulfate reduction
BSM4216_RS07915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BSM4216_RS07920	COG0187	DNA topoisomerase II activity
BSM4216_RS07925	COG1832	CoA-binding protein
BSM4216_RS07930	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BSM4216_RS07935	COG4841	protein insertion into membrane
BSM4216_RS07955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_RS07960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BSM4216_RS07975	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSM4216_RS08030	COG0686	Belongs to the AlaDH PNT family
BSM4216_RS08040	COG1999	signal sequence binding
BSM4216_RS08050	COG0419	ATPase involved in DNA repair
BSM4216_RS08055	COG0420	3'-5' exonuclease activity
BSM4216_RS08065	COG4846	Membrane protein involved in cytochrome C biogenesis
BSM4216_RS08075	COG0785	Cytochrome C biogenesis protein
BSM4216_RS08080	COG0583	DNA-binding transcription factor activity
BSM4216_RS08090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSM4216_RS08095	COG3763	UPF0154 protein
BSM4216_RS08110	COG4224	UPF0291 protein
BSM4216_RS08115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BSM4216_RS08125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BSM4216_RS08140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_RS08145	COG0640	Transcriptional regulator
BSM4216_RS08155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BSM4216_RS08160	COG2169	Transcriptional regulator
BSM4216_RS08165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BSM4216_RS08190	COG2333	competence protein COMEC
BSM4216_RS08190	COG0658	competence protein
BSM4216_RS08205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BSM4216_RS08210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BSM4216_RS08240	COG3328	transposase activity
BSM4216_RS08245	COG0174	glutamine synthetase
BSM4216_RS08250	COG0789	Transcriptional regulator
BSM4216_RS08255	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BSM4216_RS08260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BSM4216_RS08265	COG0464	growth
BSM4216_RS08270	COG1923	regulation of RNA biosynthetic process
BSM4216_RS08275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BSM4216_RS08305	COG3328	transposase activity
BSM4216_RS08320	COG1376	ErfK ybiS ycfS ynhG family protein
BSM4216_RS08325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BSM4216_RS08330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BSM4216_RS08340	COG4550	Control of competence regulator ComK, YlbF/YmcA
BSM4216_RS08345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BSM4216_RS08350	COG1013	pyruvate-flavodoxin oxidoreductase activity
BSM4216_RS08355	COG0674	pyruvate-flavodoxin oxidoreductase activity
BSM4216_RS08355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BSM4216_RS08365	COG2359	stage V sporulation protein S
BSM4216_RS08370	COG1692	metallophosphoesterase
BSM4216_RS08375	COG1418	mRNA catabolic process
BSM4216_RS08395	COG1546	Belongs to the CinA family
BSM4216_RS08395	COG1058	Belongs to the CinA family
BSM4216_RS08400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BSM4216_RS08405	COG1426	Protein conserved in bacteria
BSM4216_RS08420	COG0300	oxidoreductase activity
BSM4216_RS08425	COG0612	Peptidase, M16
BSM4216_RS08430	COG0612	Peptidase, M16
BSM4216_RS08435	COG4980	gas vesicle protein
BSM4216_RS08435	COG1674	ftsk spoiiie
BSM4216_RS08445	COG0740	serine-type endopeptidase activity
BSM4216_RS08470	COG0527	aspartate kinase activity
BSM4216_RS08475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BSM4216_RS08480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BSM4216_RS08485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSM4216_RS08490	COG1873	PFAM PRC-barrel domain
BSM4216_RS08530	COG1114	Component of the transport system for branched-chain amino acids
BSM4216_RS08540	COG4548	von Willebrand factor, type A
BSM4216_RS08545	COG0714	Associated with various cellular activities
BSM4216_RS08580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BSM4216_RS08600	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSM4216_RS08605	COG0567	Dehydrogenase, E1 component
BSM4216_RS08615	COG1119	ATPase activity
BSM4216_RS08620	COG1295	ribonuclease BN
BSM4216_RS08650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BSM4216_RS08655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BSM4216_RS08670	COG0083	homoserine kinase activity
BSM4216_RS08675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BSM4216_RS08680	COG0460	homoserine dehydrogenase
BSM4216_RS08690	COG0183	Belongs to the thiolase family
BSM4216_RS08700	COG1331	Highly conserved protein containing a thioredoxin domain
BSM4216_RS08705	COG4372	Transposase
BSM4216_RS08720	COG0840	transmembrane signaling receptor activity
BSM4216_RS08725	COG0840	transmembrane signaling receptor activity
BSM4216_RS08730	COG0840	transmembrane signaling receptor activity
BSM4216_RS08740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BSM4216_RS08745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSM4216_RS08750	COG0438	transferase activity, transferring glycosyl groups
BSM4216_RS08755	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSM4216_RS08760	COG0456	acetyltransferase
BSM4216_RS08770	COG2814	Major facilitator Superfamily
BSM4216_RS08775	COG1070	Carbohydrate kinase
BSM4216_RS08780	COG2115	Belongs to the xylose isomerase family
BSM4216_RS08790	COG2017	converts alpha-aldose to the beta-anomer
BSM4216_RS08795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BSM4216_RS08800	COG1953	Uracil, thiamine, allantoin
BSM4216_RS08805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSM4216_RS08815	COG2508	Transcriptional regulator
BSM4216_RS08820	COG2233	PERMEase
BSM4216_RS08830	COG2351	hydroxyisourate hydrolase activity
BSM4216_RS08835	COG2080	2 iron, 2 sulfur cluster binding
BSM4216_RS08840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BSM4216_RS08845	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BSM4216_RS08850	COG0402	S-adenosylhomocysteine deaminase activity
BSM4216_RS08860	COG2226	methyltransferase
BSM4216_RS08865	COG1378	Sugar-specific transcriptional regulator TrmB
BSM4216_RS08875	COG0579	oxidoreductase
BSM4216_RS08880	COG2186	Transcriptional regulator
BSM4216_RS08885	COG0277	FAD linked oxidase domain protein
BSM4216_RS08890	COG0247	lactate metabolic process
BSM4216_RS08925	COG0656	L-ascorbic acid biosynthetic process
BSM4216_RS08930	COG2368	4-hydroxyphenylacetate
BSM4216_RS08940	COG2848	UPF0210 protein
BSM4216_RS08950	COG0765	amino acid transport
BSM4216_RS08955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_RS08960	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_RS08970	COG2966	Psort location CytoplasmicMembrane, score
BSM4216_RS08975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BSM4216_RS08985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BSM4216_RS08995	COG2329	Antibiotic biosynthesis monooxygenase
BSM4216_RS09000	COG0352	thiamine-phosphate diphosphorylase activity
BSM4216_RS09005	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BSM4216_RS09010	COG0351	phosphomethylpyrimidine kinase
BSM4216_RS09020	COG0671	phosphoesterase, PA-phosphatase related
BSM4216_RS09025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BSM4216_RS09030	COG1793	dna ligase
BSM4216_RS09030	COG3285	dna ligase
BSM4216_RS09035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BSM4216_RS09040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BSM4216_RS09045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BSM4216_RS09045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BSM4216_RS09050	COG0307	riboflavin synthase, alpha
BSM4216_RS09055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSM4216_RS09055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSM4216_RS09065	COG0586	Pfam SNARE associated Golgi protein
BSM4216_RS09075	COG0534	Mate efflux family protein
BSM4216_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_RS09085	COG2340	Cysteine-rich secretory protein family
BSM4216_RS09095	COG1846	Transcriptional regulator
BSM4216_RS09100	COG3409	Peptidoglycan-binding domain 1 protein
BSM4216_RS09100	COG0793	Belongs to the peptidase S41A family
BSM4216_RS09105	COG1876	peptidase activity
BSM4216_RS09110	COG0813	purine-nucleoside phosphorylase activity
BSM4216_RS09120	COG4326	sporulation control protein
BSM4216_RS09140	COG4479	Belongs to the UPF0346 family
BSM4216_RS09145	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BSM4216_RS09155	COG2190	(PTS) system
BSM4216_RS09160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSM4216_RS09165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSM4216_RS09175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BSM4216_RS09175	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BSM4216_RS09190	COG2755	lipolytic protein G-D-S-L family
BSM4216_RS09205	COG0517	IMP dehydrogenase activity
BSM4216_RS09205	COG1125	glycine betaine transport
BSM4216_RS09220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BSM4216_RS09235	COG0166	Belongs to the GPI family
BSM4216_RS09240	COG0861	Integral membrane protein TerC family
BSM4216_RS09250	COG1413	lyase activity
BSM4216_RS09255	COG0488	(ABC) transporter
BSM4216_RS09270	COG2226	methyltransferase
BSM4216_RS09280	COG1321	iron dependent repressor
BSM4216_RS09285	COG1278	Cold shock
BSM4216_RS09290	COG0328	RNA-DNA hybrid ribonuclease activity
BSM4216_RS09295	COG0697	spore germination
BSM4216_RS09305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSM4216_RS09315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BSM4216_RS09325	COG3424	synthase
BSM4216_RS09330	COG2233	PERMEase
BSM4216_RS09335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSM4216_RS09340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BSM4216_RS09345	COG0116	Belongs to the methyltransferase superfamily
BSM4216_RS09370	COG3359	exonuclease
BSM4216_RS09375	COG1205	dead DEAH box helicase
BSM4216_RS09375	COG1111	helicase
BSM4216_RS09415	COG3331	DNA recombination
BSM4216_RS09420	COG4499	WXG100 protein secretion system (Wss), protein YukC
BSM4216_RS09420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSM4216_RS09430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BSM4216_RS09435	COG3935	DnaD domain protein
BSM4216_RS09440	COG0017	Asparaginyl-tRNA synthetase
BSM4216_RS09445	COG5353	protein conserved in bacteria
BSM4216_RS09455	COG1199	ATP-dependent helicase activity
BSM4216_RS09455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BSM4216_RS09460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BSM4216_RS09465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BSM4216_RS09470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BSM4216_RS09480	COG0617	tRNA 3'-terminal CCA addition
BSM4216_RS09485	COG0438	transferase activity, transferring glycosyl groups
BSM4216_RS09490	COG1803	Methylglyoxal synthase
BSM4216_RS09495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BSM4216_RS09500	COG1694	Mazg nucleotide pyrophosphohydrolase
BSM4216_RS09505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSM4216_RS09510	COG2738	Putative neutral zinc metallopeptidase
BSM4216_RS09520	COG4347	Protein of unknown function (DUF1405)
BSM4216_RS09525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BSM4216_RS09525	COG2010	Cytochrome c
BSM4216_RS09530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BSM4216_RS09550	COG0457	Tetratricopeptide repeat
BSM4216_RS09555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BSM4216_RS09560	COG0287	Prephenate dehydrogenase
BSM4216_RS09565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BSM4216_RS09570	COG4401	Chorismate mutase type I
BSM4216_RS09580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BSM4216_RS09585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BSM4216_RS09590	COG0105	UTP biosynthetic process
BSM4216_RS09595	COG0142	geranyltranstransferase activity
BSM4216_RS09600	COG2226	methyltransferase
BSM4216_RS09605	COG0142	geranyltranstransferase activity
BSM4216_RS09615	COG0302	gtp cyclohydrolase
BSM4216_RS09625	COG0776	regulation of translation
BSM4216_RS09630	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BSM4216_RS09645	COG0154	amidase activity
BSM4216_RS09655	COG1160	GTP binding
BSM4216_RS09680	COG0539	negative regulation of cytoplasmic translation
BSM4216_RS09685	COG0204	Acyl-transferase
BSM4216_RS09690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BSM4216_RS09705	COG2959	enzyme of heme biosynthesis
BSM4216_RS09710	COG3409	Peptidoglycan-binding domain 1 protein
BSM4216_RS09710	COG3773	Cell wall hydrolase
BSM4216_RS09715	COG2339	peptidase activity
BSM4216_RS09720	COG0252	asparaginase activity
BSM4216_RS09725	COG0517	IMP dehydrogenase activity
BSM4216_RS09740	COG0492	ferredoxin-NADP+ reductase activity
BSM4216_RS09745	COG4862	establishment of competence for transformation
BSM4216_RS09750	COG0789	Transcriptional regulator
BSM4216_RS09765	COG0531	amino acid
BSM4216_RS09770	COG4302	ethanolamine ammonia-lyase activity
BSM4216_RS09775	COG4303	Ethanolamine ammonia lyase large subunit
BSM4216_RS09800	COG3546	catalase activity
BSM4216_RS09810	COG1388	LysM domain
BSM4216_RS09815	COG1266	CAAX protease self-immunity
BSM4216_RS09820	COG0514	ATP-dependent DNA helicase (RecQ)
BSM4216_RS09825	COG4955	Helix-turn-helix domain
BSM4216_RS09830	COG1141	Ferredoxin
BSM4216_RS09835	COG0840	transmembrane signaling receptor activity
BSM4216_RS09845	COG5002	protein histidine kinase activity
BSM4216_RS09850	COG0745	RESPONSE REGULATOR receiver
BSM4216_RS09855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSM4216_RS09860	COG1333	cytochrome c biogenesis protein
BSM4216_RS09865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_RS09870	COG1187	pseudouridine synthase activity
BSM4216_RS09875	COG0700	Nucleoside recognition
BSM4216_RS09880	COG2715	membrane protein required for spore maturation
BSM4216_RS09885	COG1686	Belongs to the peptidase S11 family
BSM4216_RS09890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BSM4216_RS09895	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BSM4216_RS09900	COG1547	Domain of unknown function (DUF309)
BSM4216_RS09915	COG0697	spore germination
BSM4216_RS09935	COG2172	sigma factor antagonist activity
BSM4216_RS09960	COG4974	Belongs to the 'phage' integrase family
BSM4216_RS09970	COG0735	belongs to the Fur family
BSM4216_RS09980	COG1300	Membrane
BSM4216_RS09990	COG0667	Aldo Keto reductase
BSM4216_RS10000	COG1073	alpha beta
BSM4216_RS10015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSM4216_RS10020	COG0300	oxidoreductase activity
BSM4216_RS10025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSM4216_RS10030	COG1902	pentaerythritol trinitrate reductase activity
BSM4216_RS10035	COG1234	tRNA 3'-trailer cleavage
BSM4216_RS10040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BSM4216_RS10045	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BSM4216_RS10055	COG0351	phosphomethylpyrimidine kinase
BSM4216_RS10060	COG0561	phosphatase activity
BSM4216_RS10075	COG1263	PTS System
BSM4216_RS10075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_RS10080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BSM4216_RS10085	COG1737	Transcriptional regulator
BSM4216_RS10090	COG1132	(ABC) transporter
BSM4216_RS10115	COG1953	Uracil, thiamine, allantoin
BSM4216_RS10125	COG1454	alcohol dehydrogenase
BSM4216_RS10130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BSM4216_RS10140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BSM4216_RS10145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSM4216_RS10150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BSM4216_RS10155	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS10160	COG0835	chemotaxis
BSM4216_RS10160	COG0784	Response regulator, receiver
BSM4216_RS10165	COG2195	Cleaves the N-terminal amino acid of tripeptides
BSM4216_RS10170	COG1376	ErfK ybiS ycfS ynhG family protein
BSM4216_RS10175	COG4129	membrane
BSM4216_RS10185	COG4086	secreted protein
BSM4216_RS10190	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSM4216_RS10195	COG0022	dehydrogenase e1 component
BSM4216_RS10200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BSM4216_RS10205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSM4216_RS10215	COG3290	protein histidine kinase activity
BSM4216_RS10215	COG3829	transcription factor binding
BSM4216_RS10225	COG0584	glycerophosphoryl diester phosphodiesterase
BSM4216_RS10230	COG0745	RESPONSE REGULATOR receiver
BSM4216_RS10235	COG0750	zinc metalloprotease
BSM4216_RS10240	COG0497	DNA recombination
BSM4216_RS10245	COG1438	arginine binding
BSM4216_RS10250	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BSM4216_RS10255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BSM4216_RS10265	COG1722	exodeoxyribonuclease VII activity
BSM4216_RS10275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BSM4216_RS10280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSM4216_RS10285	COG1302	Protein conserved in bacteria
BSM4216_RS10290	COG0439	Biotin carboxylase
BSM4216_RS10295	COG0511	ligase activity, forming carbon-carbon bonds
BSM4216_RS10335	COG3854	ATPases associated with a variety of cellular activities
BSM4216_RS10340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BSM4216_RS10345	COG0006	proline dipeptidase activity
BSM4216_RS10350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BSM4216_RS10360	COG3872	metal-dependent enzyme
BSM4216_RS10370	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSM4216_RS10375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSM4216_RS10380	COG0095	Lipoate-protein ligase
BSM4216_RS10385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSM4216_RS10390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSM4216_RS10395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSM4216_RS10400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BSM4216_RS10405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BSM4216_RS10415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BSM4216_RS10440	COG4537	Required for transformation and DNA binding
BSM4216_RS10445	COG1459	type II secretion system
BSM4216_RS10450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BSM4216_RS10455	COG0737	Belongs to the 5'-nucleotidase family
BSM4216_RS10465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSM4216_RS10480	COG1368	sulfuric ester hydrolase activity
BSM4216_RS10485	COG1940	carbohydrate kinase activity
BSM4216_RS10490	COG4483	Protein conserved in bacteria
BSM4216_RS10500	COG0705	Rhomboid family
BSM4216_RS10500	COG0457	Tetratricopeptide repeat
BSM4216_RS10510	COG1836	PFAM Integral membrane protein DUF92
BSM4216_RS10515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BSM4216_RS10530	COG0438	transferase activity, transferring glycosyl groups
BSM4216_RS10550	COG0768	penicillin binding
BSM4216_RS10570	COG2839	Protein conserved in bacteria
BSM4216_RS10580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BSM4216_RS10585	COG4709	membrane
BSM4216_RS10590	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BSM4216_RS10595	COG0735	belongs to the Fur family
BSM4216_RS10605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BSM4216_RS10620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BSM4216_RS10625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BSM4216_RS10630	COG2384	SAM-dependent methyltransferase
BSM4216_RS10635	COG2010	Cytochrome c
BSM4216_RS10645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BSM4216_RS10650	COG0358	DNA primase activity
BSM4216_RS10655	COG1671	Belongs to the UPF0178 family
BSM4216_RS10660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BSM4216_RS10665	COG0517	IMP dehydrogenase activity
BSM4216_RS10670	COG0751	glycine-tRNA ligase activity
BSM4216_RS10675	COG0752	glycyl-tRNA synthetase alpha subunit
BSM4216_RS10680	COG1381	Involved in DNA repair and RecF pathway recombination
BSM4216_RS10690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BSM4216_RS10695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BSM4216_RS10700	COG1480	7TM receptor with intracellular HD hydrolase
BSM4216_RS10705	COG1702	phosphate starvation-inducible protein PhoH
BSM4216_RS10725	COG4864	UPF0365 protein
BSM4216_RS10730	COG1030	water channel activity
BSM4216_RS10735	COG1610	YqeY-like protein
BSM4216_RS10740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BSM4216_RS10745	COG0697	spore germination
BSM4216_RS10750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BSM4216_RS10755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BSM4216_RS10760	COG2264	protein methyltransferase activity
BSM4216_RS10765	COG0484	heat shock protein binding
BSM4216_RS10770	COG0443	Heat shock 70 kDa protein
BSM4216_RS10775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BSM4216_RS10785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BSM4216_RS10790	COG0481	GTPase activity
BSM4216_RS10795	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSM4216_RS10815	COG1466	dna polymerase III delta subunit
BSM4216_RS10825	COG0658	competence protein
BSM4216_RS10825	COG2333	competence protein COMEC
BSM4216_RS10830	COG2131	deaminase
BSM4216_RS10835	COG1596	polysaccharide export
BSM4216_RS10835	COG1555	photosystem II stabilization
BSM4216_RS10840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSM4216_RS10845	COG2226	methyltransferase
BSM4216_RS10850	COG0799	negative regulation of ribosome biogenesis
BSM4216_RS10855	COG1713	HD superfamily hydrolase involved in NAD metabolism
BSM4216_RS10860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BSM4216_RS10865	COG1534	Rna-binding protein
BSM4216_RS10875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BSM4216_RS10880	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BSM4216_RS10905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BSM4216_RS10915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BSM4216_RS10920	COG0572	uridine kinase
BSM4216_RS10925	COG0826	peptidase U32
BSM4216_RS10930	COG0826	peptidase U32
BSM4216_RS10935	COG4122	O-methyltransferase activity
BSM4216_RS10940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BSM4216_RS10945	COG3906	Belongs to the UPF0473 family
BSM4216_RS10950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BSM4216_RS10955	COG4472	Bacterial protein of unknown function (DUF965)
BSM4216_RS10960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BSM4216_RS10965	COG0628	permease
BSM4216_RS10975	COG3881	PFAM PRC-barrel domain
BSM4216_RS10980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BSM4216_RS10990	COG0482	sulfurtransferase activity
BSM4216_RS10995	COG1104	cysteine desulfurase activity
BSM4216_RS11000	COG1959	2 iron, 2 sulfur cluster binding
BSM4216_RS11005	COG2364	Membrane
BSM4216_RS11010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BSM4216_RS11025	COG0477	Major facilitator Superfamily
BSM4216_RS11030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BSM4216_RS11035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BSM4216_RS11040	COG0124	histidyl-tRNA synthetase
BSM4216_RS11050	COG4991	sh3 domain protein
BSM4216_RS11050	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSM4216_RS11050	COG3103	Sh3 type 3 domain protein
BSM4216_RS11055	COG1490	D-aminoacyl-tRNA deacylase activity
BSM4216_RS11060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BSM4216_RS11065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSM4216_RS11070	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BSM4216_RS11070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BSM4216_RS11075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSM4216_RS11075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSM4216_RS11085	COG2244	polysaccharide biosynthetic process
BSM4216_RS11095	COG1862	Preprotein translocase
BSM4216_RS11100	COG0343	queuine tRNA-ribosyltransferase activity
BSM4216_RS11105	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BSM4216_RS11120	COG0632	four-way junction helicase activity
BSM4216_RS11140	COG0392	lysyltransferase activity
BSM4216_RS11140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BSM4216_RS11145	COG0217	transcriptional regulatory protein
BSM4216_RS11160	COG1388	LysM domain
BSM4216_RS11165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BSM4216_RS11170	COG0157	Belongs to the NadC ModD family
BSM4216_RS11175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BSM4216_RS11180	COG1104	cysteine desulfurase activity
BSM4216_RS11185	COG1827	regulation of RNA biosynthetic process
BSM4216_RS11190	COG0077	Prephenate dehydratase
BSM4216_RS11195	COG4492	Belongs to the UPF0735 family
BSM4216_RS11200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BSM4216_RS11205	COG3290	protein histidine kinase activity
BSM4216_RS11210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BSM4216_RS11215	COG2868	ribosomal protein
BSM4216_RS11220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BSM4216_RS11225	COG1530	ribonuclease E activity
BSM4216_RS11230	COG1994	Peptidase M50
BSM4216_RS11240	COG2894	cell division
BSM4216_RS11245	COG0850	regulation of cytokinetic process
BSM4216_RS11250	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BSM4216_RS11255	COG1792	Involved in formation and maintenance of cell shape
BSM4216_RS11260	COG1077	Cell shape determining protein MreB Mrl
BSM4216_RS11265	COG2003	Belongs to the UPF0758 family
BSM4216_RS11295	COG0285	dihydrofolate synthase activity
BSM4216_RS11305	COG1301	dicarboxylic acid transport
BSM4216_RS11315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSM4216_RS11320	COG1388	LysM domain
BSM4216_RS11320	COG1388	LysM domain
BSM4216_RS11325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BSM4216_RS11330	COG0113	porphobilinogen synthase activity
BSM4216_RS11340	COG0181	hydroxymethylbilane synthase activity
BSM4216_RS11345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSM4216_RS11360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BSM4216_RS11365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BSM4216_RS11370	COG1067	ATP-dependent peptidase activity
BSM4216_RS11370	COG0470	DNA polymerase III
BSM4216_RS11375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BSM4216_RS11380	COG0544	peptidyl-prolyl cis-trans isomerase activity
BSM4216_RS11385	COG1477	protein flavinylation
BSM4216_RS11385	COG0457	Tetratricopeptide repeat
BSM4216_RS11415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BSM4216_RS11420	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BSM4216_RS11425	COG5401	PFAM Sporulation and spore germination
BSM4216_RS11430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BSM4216_RS11440	COG1695	Transcriptional regulator
BSM4216_RS11460	COG2197	response regulator
BSM4216_RS11465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BSM4216_RS11470	COG1053	succinate dehydrogenase
BSM4216_RS11475	COG2009	succinate dehydrogenase
BSM4216_RS11480	COG1719	4-vinyl reductase, 4VR
BSM4216_RS11490	COG0322	excinuclease ABC activity
BSM4216_RS11495	COG3118	belongs to the thioredoxin family
BSM4216_RS11500	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BSM4216_RS11505	COG2086	electron transfer activity
BSM4216_RS11510	COG1024	Enoyl-CoA hydratase
BSM4216_RS11515	COG1309	transcriptional regulator
BSM4216_RS11520	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_RS11525	COG1193	negative regulation of DNA recombination
BSM4216_RS11530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BSM4216_RS11530	COG1796	DNA polymerase
BSM4216_RS11540	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BSM4216_RS11550	COG0072	phenylalanine-tRNA ligase activity
BSM4216_RS11550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSM4216_RS11555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BSM4216_RS11560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSM4216_RS11570	COG1363	Peptidase, m42
BSM4216_RS11580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BSM4216_RS11600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BSM4216_RS11615	COG1484	DNA-dependent DNA replication
BSM4216_RS11620	COG3611	Membrane attachment protein
BSM4216_RS11625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BSM4216_RS11630	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BSM4216_RS11635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BSM4216_RS11640	COG0237	dephospho-CoA kinase activity
BSM4216_RS11645	COG1971	Probably functions as a manganese efflux pump
BSM4216_RS11650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BSM4216_RS11655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSM4216_RS11655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSM4216_RS11660	COG0745	RESPONSE REGULATOR receiver
BSM4216_RS11665	COG0039	L-malate dehydrogenase activity
BSM4216_RS11670	COG0538	isocitrate dehydrogenase activity
BSM4216_RS11675	COG0372	Belongs to the citrate synthase family
BSM4216_RS11680	COG2707	UPF0756 membrane protein
BSM4216_RS11685	COG0628	permease
BSM4216_RS11695	COG0205	6-phosphofructokinase activity
BSM4216_RS11700	COG0825	malonyl-CoA metabolic process
BSM4216_RS11705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BSM4216_RS11710	COG1725	Transcriptional regulator
BSM4216_RS11715	COG0281	malic enzyme
BSM4216_RS11720	COG0587	DNA-directed DNA polymerase activity
BSM4216_RS11735	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BSM4216_RS11745	COG4109	DRTGG domain
BSM4216_RS11750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BSM4216_RS11755	COG0006	proline dipeptidase activity
BSM4216_RS11765	COG0589	response to stress
BSM4216_RS11770	COG0165	Argininosuccinate lyase
BSM4216_RS11775	COG0137	argininosuccinate synthase activity
BSM4216_RS11785	COG0521	Mo-molybdopterin cofactor biosynthetic process
BSM4216_RS11795	COG0827	DNA restriction-modification system
BSM4216_RS11800	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BSM4216_RS11805	COG3874	Sporulation protein YtfJ
BSM4216_RS11815	COG1714	RDD family
BSM4216_RS11820	COG0616	signal peptide processing
BSM4216_RS11835	COG2962	Rard protein
BSM4216_RS11840	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BSM4216_RS11845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSM4216_RS11855	COG0301	tRNA thio-modification
BSM4216_RS11860	COG1104	cysteine desulfurase activity
BSM4216_RS11865	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BSM4216_RS11870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BSM4216_RS11875	COG1309	transcriptional regulator
BSM4216_RS11880	COG1956	GAF domain-containing protein
BSM4216_RS11885	COG2203	Gaf domain
BSM4216_RS11885	COG2199	diguanylate cyclase activity
BSM4216_RS11900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BSM4216_RS11910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSM4216_RS11915	COG0454	-acetyltransferase
BSM4216_RS11920	COG0517	IMP dehydrogenase activity
BSM4216_RS11925	COG0123	including yeast histone deacetylase and acetoin utilization protein
BSM4216_RS11935	COG1605	Chorismate mutase
BSM4216_RS11935	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BSM4216_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_RS11960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BSM4216_RS11965	COG1674	ftsk spoiiie
BSM4216_RS11970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSM4216_RS11975	COG4848	Belongs to the UPF0354 family
BSM4216_RS11980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_RS11985	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BSM4216_RS11990	COG1363	Peptidase, m42
BSM4216_RS12010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BSM4216_RS12020	COG0510	thiamine kinase activity
BSM4216_RS12025	COG1523	belongs to the glycosyl hydrolase 13 family
BSM4216_RS12040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSM4216_RS12050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSM4216_RS12055	COG1349	DNA-binding transcription factor activity
BSM4216_RS12060	COG1187	pseudouridine synthase activity
BSM4216_RS12065	COG2244	polysaccharide biosynthetic process
BSM4216_RS12080	COG2059	Chromate
BSM4216_RS12085	COG2059	Chromate
BSM4216_RS12090	COG0840	transmembrane signaling receptor activity
BSM4216_RS12095	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_RS12105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSM4216_RS12110	COG0495	leucyl-tRNA aminoacylation
BSM4216_RS12130	COG1242	4 iron, 4 sulfur cluster binding
BSM4216_RS12135	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BSM4216_RS12140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_RS12150	COG2267	carboxylic ester hydrolase activity
BSM4216_RS12160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BSM4216_RS12165	COG4990	cell redox homeostasis
BSM4216_RS12170	COG0367	asparagine synthase
BSM4216_RS12175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BSM4216_RS12180	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BSM4216_RS12190	COG1506	peptidase
BSM4216_RS12195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_RS12200	COG1116	anion transmembrane transporter activity
BSM4216_RS12205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_RS12210	COG0494	nUDIX hydrolase
BSM4216_RS12225	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BSM4216_RS12235	COG0697	spore germination
BSM4216_RS12245	COG0783	Belongs to the Dps family
BSM4216_RS12250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BSM4216_RS12255	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_RS12260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BSM4216_RS12265	COG0596	Alpha beta hydrolase
BSM4216_RS12270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BSM4216_RS12275	COG1169	isochorismate synthase
BSM4216_RS12280	COG1575	Belongs to the MenA family. Type 1 subfamily
BSM4216_RS12290	COG0058	SHG alpha-glucan phosphorylase activity
BSM4216_RS12295	COG0297	glycogen (starch) synthase activity
BSM4216_RS12300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BSM4216_RS12305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BSM4216_RS12430	COG1285	pathogenesis
BSM4216_RS12440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BSM4216_RS12450	COG2814	Major facilitator Superfamily
BSM4216_RS12455	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BSM4216_RS12470	COG1979	alcohol dehydrogenase
BSM4216_RS12475	COG2155	Conserved Protein
BSM4216_RS12485	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_RS12490	COG1098	S1 RNA binding domain
BSM4216_RS12495	COG0436	Aminotransferase
BSM4216_RS12500	COG1522	sequence-specific DNA binding
BSM4216_RS12505	COG2267	carboxylic ester hydrolase activity
BSM4216_RS12515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BSM4216_RS12550	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BSM4216_RS12560	COG1459	type II secretion system
BSM4216_RS12575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSM4216_RS12585	COG2050	protein possibly involved in aromatic compounds catabolism
BSM4216_RS12595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BSM4216_RS12600	COG3584	3D domain protein
BSM4216_RS12605	COG1764	response to oxidative stress
BSM4216_RS12615	COG1252	NADH dehydrogenase
BSM4216_RS12620	COG0492	ferredoxin-NADP+ reductase activity
BSM4216_RS12630	COG0316	Belongs to the HesB IscA family
BSM4216_RS12640	COG4844	belongs to the
BSM4216_RS12645	COG1252	NADH dehydrogenase
BSM4216_RS12650	COG4837	Protein of unknown function (DUF1462)
BSM4216_RS12655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BSM4216_RS12665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSM4216_RS12670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BSM4216_RS12675	COG0647	UMP catabolic process
BSM4216_RS12680	COG2445	Protein of unknown function DUF86
BSM4216_RS12695	COG4470	Protein conserved in bacteria
BSM4216_RS12705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BSM4216_RS12710	COG0739	heme binding
BSM4216_RS12720	COG0737	Belongs to the 5'-nucleotidase family
BSM4216_RS12725	COG1801	Protein of unknown function DUF72
BSM4216_RS12750	COG0719	Fe-S assembly protein
BSM4216_RS12755	COG0822	iron-sulfur transferase activity
BSM4216_RS12760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BSM4216_RS12765	COG0719	Fe-S assembly protein
BSM4216_RS12770	COG0396	ATPase activity
BSM4216_RS12780	COG1464	Belongs to the NlpA lipoprotein family
BSM4216_RS12785	COG2011	ABC-type metal ion transport system permease component
BSM4216_RS12790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BSM4216_RS12800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_RS12805	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BSM4216_RS12810	COG0509	glycine decarboxylation via glycine cleavage system
BSM4216_RS12815	COG1393	Belongs to the ArsC family
BSM4216_RS12820	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS12825	COG0183	Belongs to the thiolase family
BSM4216_RS12830	COG1024	Enoyl-CoA hydratase
BSM4216_RS12830	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSM4216_RS12835	COG3328	transposase activity
BSM4216_RS12850	COG5577	PFAM Coat F domain
BSM4216_RS12855	COG1556	Lactate utilization protein
BSM4216_RS12860	COG1139	Iron-sulfur cluster binding protein
BSM4216_RS12865	COG0247	lactate metabolic process
BSM4216_RS12870	COG2186	Transcriptional regulator
BSM4216_RS12875	COG2814	Major facilitator Superfamily
BSM4216_RS12880	COG0772	Belongs to the SEDS family
BSM4216_RS12885	COG0778	Nitroreductase
BSM4216_RS12900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BSM4216_RS12905	COG1024	Enoyl-CoA hydratase
BSM4216_RS12910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSM4216_RS12915	COG0511	ligase activity, forming carbon-carbon bonds
BSM4216_RS12920	COG0439	Biotin carboxylase
BSM4216_RS12925	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_RS12930	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS12935	COG1309	transcriptional regulator
BSM4216_RS12940	COG2996	Protein conserved in bacteria
BSM4216_RS12945	COG1388	LysM domain
BSM4216_RS12945	COG3858	chitin binding
BSM4216_RS12955	COG1473	amidohydrolase
BSM4216_RS12960	COG1619	proteins homologs of microcin C7 resistance protein MccF
BSM4216_RS12965	COG1742	UPF0060 membrane protein
BSM4216_RS12970	COG3037	sugar-specific permease SgaT UlaA
BSM4216_RS12980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSM4216_RS12985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_RS12990	COG0628	permease
BSM4216_RS12995	COG2267	carboxylic ester hydrolase activity
BSM4216_RS13010	COG0765	amino acid transport
BSM4216_RS13060	COG3344	reverse transcriptase
BSM4216_RS13065	COG2723	6-phospho-beta-galactosidase activity
BSM4216_RS13075	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_RS13080	COG0531	amino acid
BSM4216_RS13090	COG3829	transcription factor binding
BSM4216_RS13090	COG3290	protein histidine kinase activity
BSM4216_RS13095	COG0667	Aldo Keto reductase
BSM4216_RS13100	COG0442	prolyl-tRNA aminoacylation
BSM4216_RS13110	COG1309	transcriptional regulator
BSM4216_RS13125	COG4372	Transposase
BSM4216_RS13140	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BSM4216_RS13155	COG1203	CRISPR-associated helicase, Cas3
BSM4216_RS13190	COG1388	LysM domain
BSM4216_RS13190	COG0791	NLP P60 protein
BSM4216_RS13230	COG0840	transmembrane signaling receptor activity
BSM4216_RS13235	COG5577	PFAM Coat F domain
BSM4216_RS13245	COG3764	Sortase (surface protein transpeptidase)
BSM4216_RS13255	COG1595	DNA-templated transcription, initiation
BSM4216_RS13280	COG0586	Pfam SNARE associated Golgi protein
BSM4216_RS13285	COG2094	Belongs to the DNA glycosylase MPG family
BSM4216_RS13305	COG0672	)-iron permease
BSM4216_RS13310	COG2837	iron assimilation
BSM4216_RS13315	COG2822	iron ion transport
BSM4216_RS13335	COG0655	NAD(P)H dehydrogenase (quinone) activity
BSM4216_RS13340	COG2814	Major facilitator Superfamily
BSM4216_RS13345	COG1566	PFAM secretion protein HlyD family protein
BSM4216_RS13355	COG1846	Transcriptional regulator
BSM4216_RS13360	COG3842	ATPase activity
BSM4216_RS13370	COG0010	Belongs to the arginase family
BSM4216_RS13380	COG3328	transposase activity
BSM4216_RS13400	COG0347	Belongs to the P(II) protein family
BSM4216_RS13405	COG0004	ammonium transporteR
BSM4216_RS13410	COG0385	Bile acid
BSM4216_RS13435	COG2911	Protein conserved in bacteria
BSM4216_RS13435	COG1361	Conserved repeat domain
BSM4216_RS13435	COG3266	domain, Protein
BSM4216_RS13450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BSM4216_RS13455	COG2089	acid synthase
BSM4216_RS13465	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BSM4216_RS13490	COG1216	Glycosyl transferase, family 2
BSM4216_RS13510	COG1086	Polysaccharide biosynthesis protein
BSM4216_RS13515	COG2604	Protein of unknown function DUF115
BSM4216_RS13525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSM4216_RS13555	COG0531	amino acid
BSM4216_RS13560	COG0531	amino acid
BSM4216_RS13565	COG2172	sigma factor antagonist activity
BSM4216_RS13570	COG1366	Belongs to the anti-sigma-factor antagonist family
BSM4216_RS13575	COG0531	amino acid
BSM4216_RS13580	COG0473	3-isopropylmalate dehydrogenase activity
BSM4216_RS13585	COG3180	Ammonia monooxygenase
BSM4216_RS13590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BSM4216_RS13595	COG1929	Belongs to the glycerate kinase type-1 family
BSM4216_RS13600	COG2610	gluconate transmembrane transporter activity
BSM4216_RS13605	COG2132	Multicopper oxidase
BSM4216_RS13615	COG2814	Major facilitator Superfamily
BSM4216_RS13680	COG3711	transcriptional antiterminator
BSM4216_RS13710	COG1346	cytolysis
BSM4216_RS13715	COG1380	Effector of murein hydrolase LrgA
BSM4216_RS13720	COG1846	Transcriptional regulator
BSM4216_RS13740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSM4216_RS13745	COG0531	amino acid
BSM4216_RS13750	COG0655	NAD(P)H dehydrogenase (quinone) activity
BSM4216_RS13765	COG0667	Aldo Keto reductase
BSM4216_RS13780	COG1280	lysine exporter protein (LysE YggA)
BSM4216_RS13800	COG4372	Transposase
BSM4216_RS13870	COG1396	sequence-specific DNA binding
BSM4216_RS13875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSM4216_RS13880	COG2132	Multicopper oxidase
BSM4216_RS13885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSM4216_RS13890	COG1597	lipid kinase activity
BSM4216_RS13905	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BSM4216_RS13910	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BSM4216_RS13915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BSM4216_RS13920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BSM4216_RS13925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSM4216_RS13930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSM4216_RS13935	COG3344	reverse transcriptase
BSM4216_RS13940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BSM4216_RS13945	COG0154	amidase activity
BSM4216_RS13955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSM4216_RS13960	COG2224	Isocitrate lyase
BSM4216_RS13965	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BSM4216_RS13970	COG4851	CamS sex pheromone cAM373 precursor
BSM4216_RS13975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BSM4216_RS13980	COG0210	DNA helicase
BSM4216_RS13985	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BSM4216_RS13995	COG4496	protein, YerC YecD
BSM4216_RS14010	COG0151	Belongs to the GarS family
BSM4216_RS14020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BSM4216_RS14025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BSM4216_RS14030	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BSM4216_RS14040	COG0047	phosphoribosylformylglycinamidine synthase activity
BSM4216_RS14045	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BSM4216_RS14050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BSM4216_RS14055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BSM4216_RS14060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BSM4216_RS14065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BSM4216_RS14085	COG1263	PTS System
BSM4216_RS14085	COG2190	(PTS) system
BSM4216_RS14085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_RS14090	COG3711	transcriptional antiterminator
BSM4216_RS14095	COG2252	PERMEase
BSM4216_RS14100	COG0519	Catalyzes the synthesis of GMP from XMP
BSM4216_RS14100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BSM4216_RS14110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BSM4216_RS14115	COG1335	isochorismatase
BSM4216_RS14130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BSM4216_RS14135	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BSM4216_RS14140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSM4216_RS14145	COG0436	Aminotransferase
BSM4216_RS14150	COG1850	ribulose-bisphosphate carboxylase activity
BSM4216_RS14155	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BSM4216_RS14160	COG0235	Class ii aldolase
BSM4216_RS14165	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BSM4216_RS14170	COG2201	protein-glutamate methylesterase activity
BSM4216_RS14180	COG1525	nuclease
BSM4216_RS14185	COG3328	transposase activity
BSM4216_RS14195	COG0459	protein refolding
BSM4216_RS14200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BSM4216_RS14210	COG1266	CAAX protease self-immunity
BSM4216_RS14225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BSM4216_RS14240	COG0745	RESPONSE REGULATOR receiver
BSM4216_RS14245	COG0577	efflux transmembrane transporter activity
BSM4216_RS14245	COG1136	(ABC) transporter
BSM4216_RS14250	COG1136	(ABC) transporter
BSM4216_RS14260	COG0805	protein transport
BSM4216_RS14265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSM4216_RS14270	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BSM4216_RS14280	COG0488	(ABC) transporter
BSM4216_RS14285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BSM4216_RS14290	COG0456	acetyltransferase
BSM4216_RS14295	COG1214	PFAM Peptidase M22, glycoprotease
BSM4216_RS14300	COG0802	atpase or kinase
BSM4216_RS14390	COG2183	response to ionizing radiation
BSM4216_RS14400	COG1191	sigma factor activity
BSM4216_RS14405	COG2172	sigma factor antagonist activity
BSM4216_RS14415	COG2337	Toxic component of a toxin-antitoxin (TA) module
BSM4216_RS14420	COG0864	Transcriptional regulator
BSM4216_RS14430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BSM4216_RS14435	COG0736	holo-[acyl-carrier-protein] synthase activity
BSM4216_RS14440	COG0705	Rhomboid family
BSM4216_RS14445	COG0513	Belongs to the DEAD box helicase family
BSM4216_RS14455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BSM4216_RS14460	COG1181	Belongs to the D-alanine--D-alanine ligase family
BSM4216_RS14465	COG2814	Major facilitator Superfamily
BSM4216_RS14475	COG2239	Acts as a magnesium transporter
BSM4216_RS14480	COG1253	flavin adenine dinucleotide binding
BSM4216_RS14485	COG1253	flavin adenine dinucleotide binding
BSM4216_RS14490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSM4216_RS14505	COG1253	flavin adenine dinucleotide binding
BSM4216_RS14530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_RS14540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_RS14545	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BSM4216_RS14550	COG1966	Carbon starvation protein
BSM4216_RS14560	COG1164	Oligoendopeptidase f
BSM4216_RS14570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSM4216_RS14575	COG0791	NLP P60 protein
BSM4216_RS14580	COG0726	polysaccharide deacetylase
BSM4216_RS14585	COG0347	Belongs to the P(II) protein family
BSM4216_RS14590	COG0004	ammonium transporteR
BSM4216_RS14610	COG1472	Belongs to the glycosyl hydrolase 3 family
BSM4216_RS14620	COG0438	transferase activity, transferring glycosyl groups
BSM4216_RS14630	COG0297	glycogen (starch) synthase activity
BSM4216_RS14645	COG0728	peptidoglycan biosynthetic process
BSM4216_RS14650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_RS14650	COG1263	PTS System
BSM4216_RS14655	COG1486	melibiose metabolic process
BSM4216_RS14660	COG1737	Transcriptional regulator
BSM4216_RS14665	COG2190	(PTS) system
BSM4216_RS14675	COG0670	Belongs to the BI1 family
BSM4216_RS14680	COG2076	Multidrug Resistance protein
BSM4216_RS14690	COG0463	Glycosyl transferase, family 2
BSM4216_RS14705	COG0670	Belongs to the BI1 family
BSM4216_RS14735	COG4990	cell redox homeostasis
BSM4216_RS14740	COG0475	glutathione-regulated potassium exporter activity
BSM4216_RS14740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BSM4216_RS14745	COG0840	transmembrane signaling receptor activity
BSM4216_RS14750	COG1744	ABC transporter substrate-binding protein PnrA-like
BSM4216_RS14770	COG1131	(ABC) transporter
BSM4216_RS14780	COG5002	protein histidine kinase activity
BSM4216_RS14810	COG0728	peptidoglycan biosynthetic process
BSM4216_RS14825	COG5263	repeat protein
BSM4216_RS14825	COG4193	domain, Protein
BSM4216_RS14830	COG0791	NLP P60 protein
BSM4216_RS14835	COG1404	Belongs to the peptidase S8 family
BSM4216_RS14850	COG1785	Belongs to the alkaline phosphatase family
BSM4216_RS14855	COG4715	Zinc finger, swim domain protein
BSM4216_RS14860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BSM4216_RS14870	COG0629	single-stranded DNA binding
BSM4216_RS14910	COG4786	Flagellar basal body rod
BSM4216_RS14915	COG4786	Flagellar basal body rod
BSM4216_RS14920	COG1077	Cell shape determining protein MreB Mrl
BSM4216_RS14925	COG1609	Transcriptional regulator
BSM4216_RS14930	COG0739	heme binding
BSM4216_RS14935	COG2385	sporulation resulting in formation of a cellular spore
BSM4216_RS14940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BSM4216_RS14950	COG4836	Membrane
BSM4216_RS14955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BSM4216_RS14960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BSM4216_RS14965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BSM4216_RS14970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BSM4216_RS14975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BSM4216_RS14980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BSM4216_RS14985	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BSM4216_RS14990	COG0356	it plays a direct role in the translocation of protons across the membrane
BSM4216_RS15000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BSM4216_RS15005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BSM4216_RS15020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BSM4216_RS15035	COG0698	ribose 5-phosphate isomerase
BSM4216_RS15040	COG0840	transmembrane signaling receptor activity
BSM4216_RS15050	COG1971	Probably functions as a manganese efflux pump
BSM4216_RS15055	COG0009	L-threonylcarbamoyladenylate synthase
BSM4216_RS15060	COG1668	transmembrane transport
BSM4216_RS15065	COG4152	abc transporter atp-binding protein
BSM4216_RS15080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BSM4216_RS15090	COG1435	thymidine kinase activity
BSM4216_RS15100	COG0254	rRNA binding
BSM4216_RS15105	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BSM4216_RS15110	COG1494	fructose-1,6-bisphosphatase
BSM4216_RS15115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BSM4216_RS15120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BSM4216_RS15125	COG0191	fructose-bisphosphate aldolase activity
BSM4216_RS15130	COG2204	response regulator
BSM4216_RS15135	COG0504	CTP synthase activity
BSM4216_RS15140	COG3343	RNA polymerase activity
BSM4216_RS15165	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS15170	COG1960	acyl-CoA dehydrogenase activity
BSM4216_RS15175	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSM4216_RS15180	COG0183	Belongs to the thiolase family
BSM4216_RS15185	COG2181	nitrate reductase activity
BSM4216_RS15185	COG0247	lactate metabolic process
BSM4216_RS15190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSM4216_RS15200	COG0018	arginyl-trna synthetase
BSM4216_RS15205	COG4506	Protein conserved in bacteria
BSM4216_RS15210	COG0010	Belongs to the arginase family
BSM4216_RS15215	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BSM4216_RS15220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSM4216_RS15235	COG1994	Peptidase M50
BSM4216_RS15245	COG3465	dGTPase activity
BSM4216_RS15250	COG1078	dGTPase activity
BSM4216_RS15260	COG4844	belongs to the
BSM4216_RS15265	COG1879	ABC-type sugar transport system periplasmic component
BSM4216_RS15270	COG1172	Belongs to the binding-protein-dependent transport system permease family
BSM4216_RS15275	COG1129	ABC transporter
BSM4216_RS15280	COG1869	D-ribose catabolic process
BSM4216_RS15285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSM4216_RS15290	COG1609	Transcriptional regulator
BSM4216_RS15305	COG3253	May function as heme-dependent peroxidase
BSM4216_RS15315	COG2363	Small membrane protein
BSM4216_RS15330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BSM4216_RS15335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSM4216_RS15340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BSM4216_RS15345	COG0314	molybdopterin synthase activity
BSM4216_RS15350	COG0746	molybdenum cofactor guanylyltransferase activity
BSM4216_RS15360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BSM4216_RS15370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BSM4216_RS15375	COG0561	phosphatase activity
BSM4216_RS15395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BSM4216_RS15400	COG3279	Response regulator of the LytR AlgR family
BSM4216_RS15405	COG0427	acetyl-CoA hydrolase
BSM4216_RS15410	COG3328	transposase activity
BSM4216_RS15415	COG1368	sulfuric ester hydrolase activity
BSM4216_RS15420	COG2226	methyltransferase
BSM4216_RS15430	COG1388	LysM domain
BSM4216_RS15430	COG3858	chitin binding
BSM4216_RS15440	COG2851	Citrate transporter
BSM4216_RS15445	COG1470	cell adhesion involved in biofilm formation
BSM4216_RS15450	COG5434	Belongs to the glycosyl hydrolase 28 family
BSM4216_RS15460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BSM4216_RS15465	COG1442	glycosyl transferase family 8
BSM4216_RS15485	COG2195	Cleaves the N-terminal amino acid of tripeptides
BSM4216_RS15490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BSM4216_RS15495	COG0697	spore germination
BSM4216_RS15500	COG2140	Oxalate decarboxylase
BSM4216_RS15510	COG1309	transcriptional regulator
BSM4216_RS15515	COG1846	Transcriptional regulator
BSM4216_RS15520	COG0477	Major facilitator Superfamily
BSM4216_RS15595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BSM4216_RS15610	COG1428	Deoxynucleoside kinase
BSM4216_RS15615	COG1620	l-lactate permease
BSM4216_RS15625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BSM4216_RS15635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BSM4216_RS15650	COG5002	protein histidine kinase activity
BSM4216_RS15655	COG0745	RESPONSE REGULATOR receiver
BSM4216_RS15695	COG0305	Participates in initiation and elongation during chromosome replication
BSM4216_RS15700	COG0359	binds to the 23S rRNA
BSM4216_RS15705	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BSM4216_RS15715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BSM4216_RS15720	COG0629	single-stranded DNA binding
BSM4216_RS15725	COG0360	Binds together with S18 to 16S ribosomal RNA
BSM4216_RS15730	COG0012	GTP binding
BSM4216_RS15740	COG4481	Protein conserved in bacteria
BSM4216_RS15745	COG0668	transmembrane transport
BSM4216_RS15760	COG1475	DNA binding
BSM4216_RS15765	COG1192	Involved in chromosome partitioning
BSM4216_RS15770	COG1475	DNA binding
BSM4216_RS15775	COG0357	Ribosomal RNA small subunit methyltransferase G
BSM4216_RS15780	COG0445	tRNA wobble uridine modification
BSM4216_RS15785	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BSM4216_RS15790	COG0594	ribonuclease P activity
BSM4216_RS15795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BSM4216_RS15870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BSM4216_RS15895	COG4585	Histidine kinase