locus-tag	class	description
S101395_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S101395_RS00010	COG0592	DNA-directed DNA polymerase activity
S101395_RS00015	COG2501	S4 domain
S101395_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S101395_RS00030	COG0187	DNA topoisomerase II activity
S101395_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101395_RS00070	COG0516	GMP reductase activity
S101395_RS00070	COG0517	IMP dehydrogenase activity
S101395_RS00075	COG1686	Belongs to the peptidase S11 family
S101395_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
S101395_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
S101395_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S101395_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
S101395_RS00100	COG2610	gluconate transmembrane transporter activity
S101395_RS00105	COG3835	regulator
S101395_RS00120	COG1428	Deoxynucleoside kinase
S101395_RS00125	COG1428	Deoxynucleoside kinase
S101395_RS00130	COG3858	chitin binding
S101395_RS00130	COG1388	LysM domain
S101395_RS00135	COG1335	isochorismatase
S101395_RS00140	COG0590	tRNA wobble adenosine to inosine editing
S101395_RS00150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S101395_RS00155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S101395_RS00160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S101395_RS00205	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
S101395_RS00210	COG3853	Toxic anion resistance protein (TelA)
S101395_RS00215	COG1982	Orn Lys Arg decarboxylase major
S101395_RS00220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S101395_RS00225	COG3870	Protein conserved in bacteria
S101395_RS00230	COG1728	Protein conserved in bacteria
S101395_RS00235	COG0470	DNA polymerase III
S101395_RS00240	COG1774	PSP1 C-terminal conserved region
S101395_RS00245	COG4467	Involved in initiation control of chromosome replication
S101395_RS00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S101395_RS00255	COG2827	Endonuclease containing a URI domain
S101395_RS00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S101395_RS00265	COG2002	toxin-antitoxin pair type II binding
S101395_RS00270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101395_RS00270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101395_RS00275	COG0084	hydrolase, TatD family'
S101395_RS00280	COG3584	3D domain protein
S101395_RS00280	COG3583	domain protein
S101395_RS00285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S101395_RS00290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S101395_RS00300	COG4466	Protein conserved in bacteria
S101395_RS00310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S101395_RS00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101395_RS00320	COG0251	oxidation-reduction process
S101395_RS00325	COG2088	sporulation resulting in formation of a cellular spore
S101395_RS00335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S101395_RS00340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S101395_RS00345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S101395_RS00350	COG0193	aminoacyl-tRNA hydrolase activity
S101395_RS00360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S101395_RS00365	COG2002	toxin-antitoxin pair type II binding
S101395_RS00370	COG2244	polysaccharide biosynthetic process
S101395_RS00375	COG3956	TIGRFAM MazG family protein
S101395_RS00380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S101395_RS00395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S101395_RS00400	COG1098	S1 RNA binding domain
S101395_RS00415	COG2208	phosphoserine phosphatase activity
S101395_RS00420	COG2304	oxidoreductase activity
S101395_RS00425	COG0515	serine threonine protein kinase
S101395_RS00430	COG0037	tRNA processing
S101395_RS00435	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
S101395_RS00440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S101395_RS00445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S101395_RS00450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S101395_RS00460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101395_RS00465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S101395_RS00470	COG0512	Glutamine amidotransferase of anthranilate synthase
S101395_RS00475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101395_RS00480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S101395_RS00485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S101395_RS00490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S101395_RS00495	COG1396	sequence-specific DNA binding
S101395_RS00500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S101395_RS00585	COG4463	regulation of RNA biosynthetic process
S101395_RS00590	COG3880	PFAM UvrB UvrC protein
S101395_RS00595	COG3869	Catalyzes the specific phosphorylation of arginine residues in
S101395_RS00600	COG0542	response to heat
S101395_RS00605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S101395_RS00610	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S101395_RS00615	COG4956	integral membrane protein (PIN domain superfamily)
S101395_RS00620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S101395_RS00625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S101395_RS00630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S101395_RS00635	COG1045	serine acetyltransferase
S101395_RS00640	COG0215	cysteine-tRNA ligase activity
S101395_RS00650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101395_RS00655	COG3688	RNA-binding protein containing a PIN domain
S101395_RS00665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S101395_RS00675	COG0250	Participates in transcription elongation, termination and antitermination
S101395_RS00680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
S101395_RS00685	COG0081	regulation of translation
S101395_RS00690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S101395_RS00695	COG0222	ribosome binding
S101395_RS00700	COG2813	Specifically methylates the guanine in position
S101395_RS00705	COG0085	RNA polymerase activity
S101395_RS00710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S101395_RS00715	COG1358	cellular component organization or biogenesis
S101395_RS00720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S101395_RS00725	COG0049	tRNA binding
S101395_RS00730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S101395_RS00735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S101395_RS00745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S101395_RS00750	COG0088	Forms part of the polypeptide exit tunnel
S101395_RS00755	COG0089	rRNA binding
S101395_RS00760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S101395_RS00765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
S101395_RS00770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
S101395_RS00775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S101395_RS00780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S101395_RS00785	COG0255	Belongs to the universal ribosomal protein uL29 family
S101395_RS00790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S101395_RS00795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S101395_RS00800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
S101395_RS00805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S101395_RS00810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S101395_RS00815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S101395_RS00820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S101395_RS00825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S101395_RS00830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S101395_RS00840	COG0200	Binds to the 23S rRNA
S101395_RS00845	COG0201	protein transport
S101395_RS00850	COG0563	adenylate kinase activity
S101395_RS00855	COG0024	Methionine aminopeptidase
S101395_RS00860	COG2163	COG2163 Ribosomal protein L14E L6E L27E
S101395_RS00865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
S101395_RS00870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S101395_RS00875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S101395_RS00880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S101395_RS00885	COG0202	RNA polymerase activity
S101395_RS00890	COG0203	ribosomal protein L17
S101395_RS00895	COG1122	ATPase activity
S101395_RS00900	COG1122	ATPase activity
S101395_RS00905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S101395_RS00910	COG0101	tRNA pseudouridine synthase activity
S101395_RS00915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S101395_RS00920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S101395_RS00945	COG1131	(ABC) transporter
S101395_RS00975	COG3290	protein histidine kinase activity
S101395_RS01000	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101395_RS01005	COG0489	protein tyrosine kinase activity
S101395_RS01015	COG2194	sulfuric ester hydrolase activity
S101395_RS01020	COG0726	polysaccharide deacetylase
S101395_RS01060	COG1609	Transcriptional regulator
S101395_RS01070	COG1175	transmembrane transport
S101395_RS01075	COG0395	ABC-type sugar transport system, permease component
S101395_RS01095	COG2195	Cleaves the N-terminal amino acid of tripeptides
S101395_RS01105	COG1595	DNA-templated transcription, initiation
S101395_RS01115	COG2205	protein histidine kinase activity
S101395_RS01120	COG0745	RESPONSE REGULATOR receiver
S101395_RS01140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101395_RS01145	COG2723	6-phospho-beta-galactosidase activity
S101395_RS01155	COG0549	Belongs to the carbamate kinase family
S101395_RS01165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S101395_RS01170	COG2235	arginine
S101395_RS01180	COG1438	arginine binding
S101395_RS01185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101395_RS01195	COG1368	sulfuric ester hydrolase activity
S101395_RS01205	COG5444	nuclease activity
S101395_RS01225	COG0584	glycerophosphoryl diester phosphodiesterase
S101395_RS01230	COG3493	citrate carrier protein
S101395_RS01245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101395_RS01250	COG0726	polysaccharide deacetylase
S101395_RS01265	COG5294	Protein conserved in bacteria
S101395_RS01270	COG0577	efflux transmembrane transporter activity
S101395_RS01275	COG1136	(ABC) transporter
S101395_RS01285	COG2205	protein histidine kinase activity
S101395_RS01290	COG0745	RESPONSE REGULATOR receiver
S101395_RS01295	COG2706	6-phosphogluconolactonase activity
S101395_RS01300	COG1396	sequence-specific DNA binding
S101395_RS01305	COG0252	asparaginase activity
S101395_RS01310	COG1027	Aspartate ammonia-lyase
S101395_RS01315	COG1757	Na H antiporter
S101395_RS01320	COG0281	malic enzyme
S101395_RS01330	COG2116	formate transmembrane transporter activity
S101395_RS01335	COG3001	Fructosamine kinase
S101395_RS01340	COG1271	oxidase subunit
S101395_RS01345	COG1294	oxidase, subunit
S101395_RS01350	COG4988	ABC transporter
S101395_RS01355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S101395_RS01360	COG2311	Membrane
S101395_RS01365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S101395_RS01375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S101395_RS01385	COG0753	catalase activity
S101395_RS01390	COG0753	catalase activity
S101395_RS01395	COG2814	Major facilitator Superfamily
S101395_RS01400	COG1595	DNA-templated transcription, initiation
S101395_RS01420	COG1131	(ABC) transporter
S101395_RS01425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101395_RS01430	COG2814	Major facilitator Superfamily
S101395_RS01440	COG2755	lipolytic protein G-D-S-L family
S101395_RS01445	COG1132	(ABC) transporter
S101395_RS01460	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S101395_RS01465	COG2079	MmgE PrpD family protein
S101395_RS01470	COG0372	Belongs to the citrate synthase family
S101395_RS01475	COG2186	Transcriptional regulator
S101395_RS01485	COG1086	Polysaccharide biosynthesis protein
S101395_RS01495	COG2094	Belongs to the DNA glycosylase MPG family
S101395_RS01500	COG3711	transcriptional antiterminator
S101395_RS01500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS01505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101395_RS01510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101395_RS01515	COG1447	Phosphotransferase system cellobiose-specific component IIA
S101395_RS01520	COG1486	melibiose metabolic process
S101395_RS01525	COG2814	Major facilitator Superfamily
S101395_RS01530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101395_RS01535	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S101395_RS01540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101395_RS01545	COG1696	Membrane protein involved in D-alanine export
S101395_RS01550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101395_RS01560	COG2357	RelA SpoT domain protein
S101395_RS01565	COG1335	isochorismatase
S101395_RS01570	COG0477	Major facilitator Superfamily
S101395_RS01595	COG2234	aminopeptidase activity
S101395_RS01600	COG1414	Transcriptional regulator
S101395_RS01605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101395_RS01610	COG0800	Aldolase
S101395_RS01615	COG4948	Mandelate Racemase Muconate Lactonizing
S101395_RS01620	COG2271	Major facilitator Superfamily
S101395_RS01625	COG5522	Integral membrane protein (intg_mem_TP0381)
S101395_RS01630	COG2409	Drug exporters of the RND superfamily
S101395_RS01635	COG2197	response regulator
S101395_RS01640	COG4585	Histidine kinase
S101395_RS01655	COG1442	glycosyl transferase family 8
S101395_RS01660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101395_RS01665	COG0346	lactoylglutathione lyase activity
S101395_RS01670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S101395_RS01675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101395_RS01680	COG1346	cytolysis
S101395_RS01685	COG1380	Effector of murein hydrolase LrgA
S101395_RS01700	COG0583	DNA-binding transcription factor activity
S101395_RS01705	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S101395_RS01710	COG0352	thiamine-phosphate diphosphorylase activity
S101395_RS01715	COG1940	carbohydrate kinase activity
S101395_RS01720	COG2115	Belongs to the xylose isomerase family
S101395_RS01725	COG1070	Carbohydrate kinase
S101395_RS01730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101395_RS01735	COG3162	membrane
S101395_RS01740	COG0655	NAD(P)H dehydrogenase (quinone) activity
S101395_RS01750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S101395_RS01755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S101395_RS01760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S101395_RS01770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S101395_RS01775	COG0456	acetyltransferase
S101395_RS01785	COG3314	Sporulation integral membrane protein YlbJ
S101395_RS01790	COG0772	Belongs to the SEDS family
S101395_RS01795	COG0772	Belongs to the SEDS family
S101395_RS01800	COG1473	amidohydrolase
S101395_RS01805	COG0778	Nitroreductase
S101395_RS01810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101395_RS01820	COG1404	Belongs to the peptidase S8 family
S101395_RS01830	COG3711	transcriptional antiterminator
S101395_RS01835	COG1263	PTS System
S101395_RS01835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS01840	COG1621	beta-fructofuranosidase activity
S101395_RS01850	COG0351	phosphomethylpyrimidine kinase
S101395_RS01855	COG1216	Glycosyl transferase, family 2
S101395_RS01860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S101395_RS01875	COG2363	Small membrane protein
S101395_RS01890	COG1131	(ABC) transporter
S101395_RS01910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101395_RS01920	COG3253	May function as heme-dependent peroxidase
S101395_RS01925	COG0280	phosphate acetyltransferase
S101395_RS01935	COG1414	Transcriptional regulator
S101395_RS01960	COG2814	Major facilitator Superfamily
S101395_RS01985	COG4844	belongs to the
S101395_RS01990	COG1078	dGTPase activity
S101395_RS01995	COG3465	dGTPase activity
S101395_RS02005	COG1942	4-Oxalocrotonate Tautomerase
S101395_RS02010	COG1994	Peptidase M50
S101395_RS02020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101395_RS02035	COG1131	(ABC) transporter
S101395_RS02050	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S101395_RS02055	COG0010	Belongs to the arginase family
S101395_RS02060	COG4506	Protein conserved in bacteria
S101395_RS02065	COG0018	arginyl-trna synthetase
S101395_RS02080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101395_RS02085	COG2181	nitrate reductase activity
S101395_RS02085	COG0247	lactate metabolic process
S101395_RS02090	COG0183	Belongs to the thiolase family
S101395_RS02095	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101395_RS02100	COG1960	acyl-CoA dehydrogenase activity
S101395_RS02105	COG1960	acyl-CoA dehydrogenase activity
S101395_RS02110	COG3343	RNA polymerase activity
S101395_RS02115	COG0504	CTP synthase activity
S101395_RS02120	COG4821	SIS domain
S101395_RS02125	COG2204	response regulator
S101395_RS02130	COG0191	fructose-bisphosphate aldolase activity
S101395_RS02135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S101395_RS02140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101395_RS02145	COG1494	fructose-1,6-bisphosphatase
S101395_RS02150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S101395_RS02160	COG1435	thymidine kinase activity
S101395_RS02165	COG0281	malic enzyme
S101395_RS02175	COG0679	Auxin Efflux Carrier
S101395_RS02180	COG0789	Transcriptional regulator
S101395_RS02185	COG0346	lactoylglutathione lyase activity
S101395_RS02190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S101395_RS02195	COG2890	protein-(glutamine-N5) methyltransferase activity
S101395_RS02200	COG1609	Transcriptional regulator
S101395_RS02205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101395_RS02210	COG0561	phosphatase activity
S101395_RS02220	COG0738	Major facilitator superfamily
S101395_RS02230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S101395_RS02235	COG0009	L-threonylcarbamoyladenylate synthase
S101395_RS02240	COG1971	Probably functions as a manganese efflux pump
S101395_RS02245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101395_RS02250	COG0698	ribose 5-phosphate isomerase
S101395_RS02255	COG4475	Protein of unknown function (DUF436)
S101395_RS02260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S101395_RS02265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S101395_RS02280	COG0356	it plays a direct role in the translocation of protons across the membrane
S101395_RS02285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S101395_RS02290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S101395_RS02295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S101395_RS02300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S101395_RS02305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S101395_RS02310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S101395_RS02315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S101395_RS02320	COG4836	Membrane
S101395_RS02330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101395_RS02335	COG2385	sporulation resulting in formation of a cellular spore
S101395_RS02340	COG2304	oxidoreductase activity
S101395_RS02345	COG2304	oxidoreductase activity
S101395_RS02350	COG0243	molybdopterin cofactor binding
S101395_RS02355	COG2223	nitrite transmembrane transporter activity
S101395_RS02360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S101395_RS02365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S101395_RS02375	COG1994	Peptidase M50
S101395_RS02385	COG1959	2 iron, 2 sulfur cluster binding
S101395_RS02390	COG2910	NAD(P)H-binding
S101395_RS02400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101395_RS02400	COG2207	Transcriptional regulator
S101395_RS02405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101395_RS02410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS02415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS02420	COG2819	hydrolase of the alpha beta superfamily
S101395_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS02430	COG1169	isochorismate synthase
S101395_RS02435	COG1021	2,3-dihydroxybenzoate-AMP ligase
S101395_RS02440	COG3433	isochorismatase activity
S101395_RS02440	COG1535	isochorismatase
S101395_RS02445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101395_RS02450	COG3251	PFAM MbtH domain protein
S101395_RS02455	COG0477	Major facilitator Superfamily
S101395_RS02460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101395_RS02470	COG1247	-acetyltransferase
S101395_RS02475	COG0739	heme binding
S101395_RS02485	COG0740	serine-type endopeptidase activity
S101395_RS02495	COG0347	Belongs to the P(II) protein family
S101395_RS02500	COG0004	ammonium transporteR
S101395_RS02505	COG1253	flavin adenine dinucleotide binding
S101395_RS02510	COG0598	Magnesium transport protein CorA
S101395_RS02515	COG0517	IMP dehydrogenase activity
S101395_RS02525	COG1309	transcriptional regulator
S101395_RS02530	COG3361	conserved protein (COG2071)
S101395_RS02535	COG3546	catalase activity
S101395_RS02540	COG1227	inorganic diphosphatase activity
S101395_RS02545	COG0671	phosphoesterase, PA-phosphatase related
S101395_RS02550	COG2814	Major facilitator Superfamily
S101395_RS02555	COG1846	Transcriptional regulator
S101395_RS02565	COG1609	Transcriptional regulator
S101395_RS02570	COG1077	Cell shape determining protein MreB Mrl
S101395_RS02575	COG4786	Flagellar basal body rod
S101395_RS02580	COG4786	Flagellar basal body rod
S101395_RS02585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101395_RS02590	COG1970	mechanosensitive ion channel activity
S101395_RS02600	COG0629	single-stranded DNA binding
S101395_RS02620	COG3732	PTS system glucitol sorbitol-specific
S101395_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS02645	COG0561	phosphatase activity
S101395_RS02650	COG0804	urea catabolic process
S101395_RS02655	COG0832	Belongs to the urease beta subunit family
S101395_RS02660	COG0831	urea catabolic process
S101395_RS02665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S101395_RS02670	COG4715	Zinc finger, swim domain protein
S101395_RS02685	COG4464	protein tyrosine phosphatase activity
S101395_RS02690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101395_RS02695	COG2059	Chromate
S101395_RS02700	COG2059	Chromate
S101395_RS02705	COG1522	sequence-specific DNA binding
S101395_RS02715	COG0583	DNA-binding transcription factor activity
S101395_RS02720	COG0028	Belongs to the TPP enzyme family
S101395_RS02725	COG3527	Alpha-acetolactate decarboxylase
S101395_RS02735	COG0583	DNA-binding transcription factor activity
S101395_RS02740	COG1879	ABC-type sugar transport system periplasmic component
S101395_RS02755	COG1869	D-ribose catabolic process
S101395_RS02760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101395_RS02765	COG1609	Transcriptional regulator
S101395_RS02770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101395_RS02780	COG2843	Capsule synthesis protein
S101395_RS02790	COG0791	NLP P60 protein
S101395_RS02795	COG0561	phosphatase activity
S101395_RS02800	COG1316	TRANSCRIPTIONal
S101395_RS02805	COG2814	Major facilitator Superfamily
S101395_RS02810	COG1063	alcohol dehydrogenase
S101395_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS02820	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S101395_RS02825	COG1609	Transcriptional regulator
S101395_RS02830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101395_RS02835	COG0800	Aldolase
S101395_RS02845	COG1328	CTP reductase activity
S101395_RS02855	COG1482	cell wall glycoprotein biosynthetic process
S101395_RS02860	COG4193	domain, Protein
S101395_RS02870	COG0438	transferase activity, transferring glycosyl groups
S101395_RS02875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
S101395_RS02880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S101395_RS02900	COG4193	domain, Protein
S101395_RS02905	COG1134	teichoic acid transport
S101395_RS02910	COG1682	transport, permease protein
S101395_RS02915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101395_RS02925	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S101395_RS02930	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S101395_RS02935	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101395_RS02940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101395_RS02945	COG1316	TRANSCRIPTIONal
S101395_RS02955	COG2385	sporulation resulting in formation of a cellular spore
S101395_RS02955	COG2247	cell wall binding repeat
S101395_RS02960	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101395_RS02960	COG2247	cell wall binding repeat
S101395_RS02970	COG2244	polysaccharide biosynthetic process
S101395_RS02975	COG0438	transferase activity, transferring glycosyl groups
S101395_RS02975	COG0297	glycogen (starch) synthase activity
S101395_RS02980	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101395_RS02985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101395_RS02990	COG3307	-O-antigen
S101395_RS02995	COG3206	protein involved in exopolysaccharide biosynthesis
S101395_RS03000	COG1215	transferase activity, transferring glycosyl groups
S101395_RS03005	COG0438	transferase activity, transferring glycosyl groups
S101395_RS03010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101395_RS03015	COG1316	TRANSCRIPTIONal
S101395_RS03020	COG1739	Uncharacterized protein family UPF0029
S101395_RS03025	COG4585	Histidine kinase
S101395_RS03030	COG2197	response regulator
S101395_RS03035	COG1307	EDD domain protein, DegV family
S101395_RS03040	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S101395_RS03050	COG1040	competence protein
S101395_RS03060	COG2747	anti-sigma28 factor FlgM
S101395_RS03065	COG3418	PFAM FlgN family protein
S101395_RS03070	COG1256	bacterial-type flagellum assembly
S101395_RS03070	COG4786	Flagellar basal body rod
S101395_RS03075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101395_RS03085	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
S101395_RS03090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S101395_RS03095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101395_RS03100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101395_RS03105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101395_RS03110	COG1334	flagellar protein FlaG
S101395_RS03115	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S101395_RS03120	COG1516	flagellar protein fliS
S101395_RS03135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S101395_RS03140	COG0653	protein targeting
S101395_RS03150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101395_RS03155	COG2010	Cytochrome c
S101395_RS03160	COG2884	Cell division ATP-binding protein ftsE
S101395_RS03165	COG2177	Part of the ABC transporter FtsEX involved in
S101395_RS03170	COG0791	NLP P60 protein
S101395_RS03170	COG3883	PFAM NLP P60 protein
S101395_RS03175	COG0473	3-isopropylmalate dehydrogenase activity
S101395_RS03180	COG3409	Peptidoglycan-binding domain 1 protein
S101395_RS03180	COG0793	Belongs to the peptidase S41A family
S101395_RS03190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101395_RS03200	COG4897	Protein conserved in bacteria
S101395_RS03205	COG0556	nucleotide-excision repair
S101395_RS03210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S101395_RS03230	COG3595	metallopeptidase activity
S101395_RS03235	COG1983	PspC domain protein
S101395_RS03240	COG1950	PFAM Membrane protein of
S101395_RS03245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S101395_RS03250	COG2814	Major facilitator Superfamily
S101395_RS03255	COG1846	Transcriptional regulator
S101395_RS03260	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S101395_RS03265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S101395_RS03270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S101395_RS03275	COG0546	phosphoglycolate phosphatase activity
S101395_RS03280	COG0110	maltose O-acetyltransferase activity
S101395_RS03285	COG5297	Belongs to the glycosyl hydrolase family 6
S101395_RS03290	COG3858	chitin binding
S101395_RS03295	COG4990	cell redox homeostasis
S101395_RS03300	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S101395_RS03305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S101395_RS03310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S101395_RS03315	COG0131	Imidazoleglycerol-phosphate dehydratase
S101395_RS03320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S101395_RS03325	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S101395_RS03330	COG0107	imidazoleglycerol-phosphate synthase activity
S101395_RS03335	COG0140	phosphoribosyl-ATP diphosphatase activity
S101395_RS03335	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S101395_RS03340	COG0457	Tetratricopeptide repeat
S101395_RS03345	COG0492	ferredoxin-NADP+ reductase activity
S101395_RS03355	COG1051	belongs to the nudix hydrolase family
S101395_RS03360	COG1660	Displays ATPase and GTPase activities
S101395_RS03365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S101395_RS03370	COG1481	regulation of sporulation
S101395_RS03375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS03380	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S101395_RS03385	COG0745	RESPONSE REGULATOR receiver
S101395_RS03390	COG5002	protein histidine kinase activity
S101395_RS03395	COG1136	(ABC) transporter
S101395_RS03400	COG0577	efflux transmembrane transporter activity
S101395_RS03405	COG0640	Transcriptional regulator
S101395_RS03410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S101395_RS03415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101395_RS03420	COG0288	reversible hydration of carbon dioxide
S101395_RS03425	COG0659	secondary active sulfate transmembrane transporter activity
S101395_RS03430	COG1078	dGTPase activity
S101395_RS03435	COG1694	Mazg nucleotide pyrophosphohydrolase
S101395_RS03440	COG1611	Belongs to the LOG family
S101395_RS03450	COG0740	serine-type endopeptidase activity
S101395_RS03470	COG4221	oxidoreductase activity
S101395_RS03480	COG1621	beta-fructofuranosidase activity
S101395_RS03485	COG1621	beta-fructofuranosidase activity
S101395_RS03490	COG1902	pentaerythritol trinitrate reductase activity
S101395_RS03500	COG2249	NAD(P)H dehydrogenase (quinone) activity
S101395_RS03505	COG1396	sequence-specific DNA binding
S101395_RS03510	COG3944	biosynthesis protein
S101395_RS03515	COG0489	protein tyrosine kinase activity
S101395_RS03520	COG1086	Polysaccharide biosynthesis protein
S101395_RS03525	COG0438	transferase activity, transferring glycosyl groups
S101395_RS03530	COG1215	transferase activity, transferring glycosyl groups
S101395_RS03535	COG0438	transferase activity, transferring glycosyl groups
S101395_RS03545	COG1216	Glycosyl transferase, family 2
S101395_RS03550	COG5039	Polysaccharide pyruvyl transferase
S101395_RS03555	COG1216	Glycosyl transferase, family 2
S101395_RS03560	COG2244	polysaccharide biosynthetic process
S101395_RS03565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S101395_RS03570	COG0110	maltose O-acetyltransferase activity
S101395_RS03575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101395_RS03580	COG5039	Polysaccharide pyruvyl transferase
S101395_RS03590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S101395_RS03595	COG1620	l-lactate permease
S101395_RS03600	COG2186	Transcriptional regulator
S101395_RS03605	COG0247	lactate metabolic process
S101395_RS03610	COG1139	Iron-sulfur cluster binding protein
S101395_RS03615	COG1556	Lactate utilization protein
S101395_RS03630	COG4978	Transcriptional regulator
S101395_RS03630	COG0789	Transcriptional regulator
S101395_RS03655	COG1113	amino acid transport
S101395_RS03660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101395_RS03670	COG2814	Major facilitator Superfamily
S101395_RS03675	COG2390	Transcriptional regulator
S101395_RS03680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S101395_RS03685	COG0126	phosphoglycerate kinase activity
S101395_RS03690	COG0149	triose-phosphate isomerase activity
S101395_RS03695	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S101395_RS03700	COG0148	phosphopyruvate hydratase activity
S101395_RS03710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101395_RS03715	COG4640	response to antibiotic
S101395_RS03720	COG3064	Membrane
S101395_RS03725	COG2095	MarC family integral membrane protein
S101395_RS03730	COG1510	regulation of RNA biosynthetic process
S101395_RS03735	COG1125	glycine betaine transport
S101395_RS03735	COG0517	IMP dehydrogenase activity
S101395_RS03740	COG1174	glycine betaine transport
S101395_RS03745	COG1732	Glycine betaine
S101395_RS03750	COG1174	glycine betaine transport
S101395_RS03755	COG1396	sequence-specific DNA binding
S101395_RS03760	COG1396	sequence-specific DNA binding
S101395_RS03765	COG1476	TRANSCRIPTIONal
S101395_RS03770	COG2002	toxin-antitoxin pair type II binding
S101395_RS03775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S101395_RS03780	COG1647	Serine aminopeptidase, S33
S101395_RS03785	COG0557	exoribonuclease II activity
S101395_RS03790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S101395_RS03950	COG4626	Terminase
S101395_RS03950	COG1802	Transcriptional regulator
S101395_RS04010	COG3953	SLT domain
S101395_RS04010	COG5280	Phage tail tape measure protein TP901
S101395_RS04020	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101395_RS04025	COG5434	Belongs to the glycosyl hydrolase 28 family
S101395_RS04065	COG5444	nuclease activity
S101395_RS04095	COG5634	Uncharacterized conserved protein (DUF2278)
S101395_RS04100	COG0402	S-adenosylhomocysteine deaminase activity
S101395_RS04125	COG1309	transcriptional regulator
S101395_RS04130	COG0574	Belongs to the PEP-utilizing enzyme family
S101395_RS04130	COG3848	Pyruvate phosphate dikinase
S101395_RS04140	COG3189	MarR family transcriptional regulator
S101395_RS04145	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
S101395_RS04150	COG2272	Belongs to the type-B carboxylesterase lipase family
S101395_RS04155	COG2814	Major facilitator Superfamily
S101395_RS04165	COG0640	Transcriptional regulator
S101395_RS04175	COG1378	Sugar-specific transcriptional regulator TrmB
S101395_RS04180	COG1280	lysine exporter protein (LysE YggA)
S101395_RS04185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S101395_RS04215	COG0726	polysaccharide deacetylase
S101395_RS04225	COG1609	Transcriptional regulator
S101395_RS04230	COG0366	Alpha amylase catalytic
S101395_RS04235	COG2182	Extracellular solute-binding protein
S101395_RS04240	COG1175	transmembrane transport
S101395_RS04245	COG3833	ABC-type maltose transport systems, permease component
S101395_RS04250	COG5521	maltodextrose utilization protein MalA
S101395_RS04255	COG1554	hydrolase, family 65, central catalytic
S101395_RS04260	COG0366	Alpha amylase catalytic
S101395_RS04265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101395_RS04290	COG3655	Transcriptional regulator
S101395_RS04295	COG3739	integral membrane protein
S101395_RS04300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S101395_RS04305	COG0823	Involved in the tonB-independent uptake of proteins
S101395_RS04325	COG0702	epimerase
S101395_RS04335	COG2132	Multicopper oxidase
S101395_RS04345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101395_RS04350	COG0714	Associated with various cellular activities
S101395_RS04355	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S101395_RS04360	COG1305	Transglutaminase-like
S101395_RS04365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S101395_RS04365	COG0519	Catalyzes the synthesis of GMP from XMP
S101395_RS04370	COG2252	PERMEase
S101395_RS04380	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S101395_RS04390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S101395_RS04395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S101395_RS04400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S101395_RS04405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S101395_RS04410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101395_RS04415	COG0047	phosphoribosylformylglycinamidine synthase activity
S101395_RS04420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101395_RS04425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S101395_RS04430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S101395_RS04435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S101395_RS04440	COG0138	bifunctional purine biosynthesis protein purh
S101395_RS04445	COG0151	Belongs to the GarS family
S101395_RS04455	COG2124	cytochrome p450
S101395_RS04465	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S101395_RS04470	COG1470	cell adhesion involved in biofilm formation
S101395_RS04475	COG4496	protein, YerC YecD
S101395_RS04480	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
S101395_RS04485	COG0210	DNA helicase
S101395_RS04490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S101395_RS04500	COG2188	Transcriptional regulator
S101395_RS04520	COG1735	metal-dependent hydrolase with the TIM-barrel fold
S101395_RS04525	COG0626	cystathionine gamma-synthase activity
S101395_RS04530	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S101395_RS04535	COG3457	Alanine racemase
S101395_RS04540	COG1285	pathogenesis
S101395_RS04550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101395_RS04555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101395_RS04560	COG0154	amidase activity
S101395_RS04565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101395_RS04575	COG1063	alcohol dehydrogenase
S101395_RS04580	COG1309	transcriptional regulator
S101395_RS04585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S101395_RS04590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101395_RS04595	COG1957	nucleoside hydrolase
S101395_RS04600	COG1597	lipid kinase activity
S101395_RS04605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101395_RS04620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101395_RS04625	COG1263	PTS System
S101395_RS04625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS04625	COG2190	(PTS) system
S101395_RS04630	COG2723	6-phospho-beta-galactosidase activity
S101395_RS04635	COG3711	transcriptional antiterminator
S101395_RS04645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101395_RS04645	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
S101395_RS04650	COG3586	endonuclease activity
S101395_RS04655	COG0697	spore germination
S101395_RS04660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101395_RS04665	COG0217	transcriptional regulatory protein
S101395_RS04685	COG0471	metal ion transport
S101395_RS04690	COG0281	malic enzyme
S101395_RS04695	COG0583	DNA-binding transcription factor activity
S101395_RS04700	COG1012	belongs to the aldehyde dehydrogenase family
S101395_RS04705	COG0840	transmembrane signaling receptor activity
S101395_RS04710	COG5444	nuclease activity
S101395_RS04715	COG0471	metal ion transport
S101395_RS04720	COG0488	(ABC) transporter
S101395_RS04725	COG0640	Transcriptional regulator
S101395_RS04730	COG2814	Major facilitator Superfamily
S101395_RS04735	COG1469	GTP cyclohydrolase I activity
S101395_RS04750	COG0523	cobalamin synthesis protein
S101395_RS04755	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
S101395_RS04760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101395_RS04770	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
S101395_RS04775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S101395_RS04785	COG0789	Transcriptional regulator
S101395_RS04790	COG2814	Major facilitator Superfamily
S101395_RS04795	COG0488	(ABC) transporter
S101395_RS04800	COG0513	Belongs to the DEAD box helicase family
S101395_RS04820	COG0471	metal ion transport
S101395_RS04835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101395_RS04845	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
S101395_RS04850	COG3858	chitin binding
S101395_RS04865	COG5658	integral membrane protein
S101395_RS04870	COG0640	Transcriptional regulator
S101395_RS04875	COG1254	Belongs to the acylphosphatase family
S101395_RS04880	COG2258	MOSC domain
S101395_RS04895	COG0024	Methionine aminopeptidase
S101395_RS04900	COG1368	sulfuric ester hydrolase activity
S101395_RS04910	COG1115	amino acid carrier protein
S101395_RS04915	COG1263	PTS System
S101395_RS04915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS04920	COG0366	Alpha amylase catalytic
S101395_RS04925	COG2188	Transcriptional regulator
S101395_RS04945	COG0463	Glycosyl transferase, family 2
S101395_RS04950	COG0463	Glycosyl transferase, family 2
S101395_RS04950	COG0457	Tetratricopeptide repeat
S101395_RS04960	COG0673	inositol 2-dehydrogenase activity
S101395_RS04970	COG1073	alpha beta
S101395_RS04975	COG1733	regulation of RNA biosynthetic process
S101395_RS04980	COG0778	Nitroreductase
S101395_RS04985	COG0737	Belongs to the 5'-nucleotidase family
S101395_RS04990	COG0693	protein deglycase activity
S101395_RS04995	COG4840	Belongs to the UPF0435 family
S101395_RS05000	COG1115	amino acid carrier protein
S101395_RS05005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101395_RS05010	COG4980	gas vesicle protein
S101395_RS05015	COG1295	ribonuclease BN
S101395_RS05020	COG0477	Major facilitator Superfamily
S101395_RS05030	COG0387	Pfam Sodium calcium exchanger
S101395_RS05040	COG0535	radical SAM domain protein
S101395_RS05050	COG0726	polysaccharide deacetylase
S101395_RS05055	COG0371	Dehydrogenase
S101395_RS05070	COG0598	Magnesium transport protein CorA
S101395_RS05075	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S101395_RS05080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101395_RS05095	COG0477	Major facilitator Superfamily
S101395_RS05100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS05100	COG1263	PTS System
S101395_RS05105	COG3711	transcriptional antiterminator
S101395_RS05115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101395_RS05120	COG0022	dehydrogenase e1 component
S101395_RS05125	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101395_RS05130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101395_RS05135	COG3284	Transcriptional regulator
S101395_RS05140	COG1742	UPF0060 membrane protein
S101395_RS05145	COG1486	melibiose metabolic process
S101395_RS05150	COG1737	Transcriptional regulator
S101395_RS05165	COG1733	regulation of RNA biosynthetic process
S101395_RS05170	COG2259	Doxx family
S101395_RS05175	COG2514	catechol 2,3-dioxygenase activity
S101395_RS05190	COG1917	Cupin 2, conserved barrel domain protein
S101395_RS05190	COG2207	Transcriptional regulator
S101395_RS05195	COG1653	transport
S101395_RS05200	COG1309	transcriptional regulator
S101395_RS05205	COG2814	Major facilitator Superfamily
S101395_RS05210	COG2249	NAD(P)H dehydrogenase (quinone) activity
S101395_RS05215	COG1051	belongs to the nudix hydrolase family
S101395_RS05225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S101395_RS05225	COG0392	lysyltransferase activity
S101395_RS05230	COG0384	phenazine biosynthesis protein PhzF
S101395_RS05235	COG0778	Nitroreductase
S101395_RS05255	COG1090	epimerase
S101395_RS05260	COG2137	regulation of response to DNA damage stimulus
S101395_RS05285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101395_RS05290	COG0463	Glycosyl transferase, family 2
S101395_RS05305	COG1988	membrane-bound metal-dependent
S101395_RS05310	COG1194	a g-specific adenine glycosylase
S101395_RS05320	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS05335	COG3557	Belongs to the UPF0374 family
S101395_RS05340	COG1132	(ABC) transporter
S101395_RS05345	COG0444	Belongs to the ABC transporter superfamily
S101395_RS05350	COG4608	Belongs to the ABC transporter superfamily
S101395_RS05355	COG0747	negative chemotaxis
S101395_RS05360	COG0601	transmembrane transport
S101395_RS05365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101395_RS05370	COG4129	membrane
S101395_RS05375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S101395_RS05380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S101395_RS05385	COG0735	belongs to the Fur family
S101395_RS05490	COG4974	Belongs to the 'phage' integrase family
S101395_RS05585	COG1396	sequence-specific DNA binding
S101395_RS05615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101395_RS05615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101395_RS05650	COG1780	Probably involved in ribonucleotide reductase function
S101395_RS05655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101395_RS05660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101395_RS05680	COG3584	3D domain protein
S101395_RS05800	COG0582	viral genome integration into host DNA
S101395_RS05910	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101395_RS05910	COG1388	LysM domain
S101395_RS05910	COG3409	Peptidoglycan-binding domain 1 protein
S101395_RS05955	COG1510	regulation of RNA biosynthetic process
S101395_RS05960	COG1012	belongs to the aldehyde dehydrogenase family
S101395_RS05965	COG1454	alcohol dehydrogenase
S101395_RS05980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101395_RS05985	COG0569	domain protein
S101395_RS05990	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
S101395_RS05995	COG0457	Tetratricopeptide repeat
S101395_RS06010	COG3764	Sortase (surface protein transpeptidase)
S101395_RS06015	COG3859	Proton-coupled thiamine transporter YuaJ
S101395_RS06020	COG1609	Transcriptional regulator
S101395_RS06170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101395_RS06175	COG1575	Belongs to the MenA family. Type 1 subfamily
S101395_RS06180	COG1169	isochorismate synthase
S101395_RS06185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
S101395_RS06190	COG0596	Alpha beta hydrolase
S101395_RS06195	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S101395_RS06200	COG0318	PFAM AMP-dependent synthetase and ligase
S101395_RS06205	COG4948	Mandelate Racemase Muconate Lactonizing
S101395_RS06210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101395_RS06215	COG0456	acetyltransferase
S101395_RS06220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101395_RS06225	COG0765	amino acid transport
S101395_RS06230	COG1126	abc transporter atp-binding protein
S101395_RS06235	COG1473	amidohydrolase
S101395_RS06240	COG2079	MmgE PrpD family protein
S101395_RS06255	COG1294	oxidase, subunit
S101395_RS06260	COG1271	oxidase subunit
S101395_RS06265	COG0254	rRNA binding
S101395_RS06270	COG0803	Belongs to the bacterial solute-binding protein 9 family
S101395_RS06275	COG0288	reversible hydration of carbon dioxide
S101395_RS06280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S101395_RS06285	COG1854	S-ribosylhomocysteine lyase activity
S101395_RS06300	COG0783	Belongs to the Dps family
S101395_RS06305	COG4824	toxin secretion phage lysis holin
S101395_RS06325	COG0494	nUDIX hydrolase
S101395_RS06330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101395_RS06335	COG1116	anion transmembrane transporter activity
S101395_RS06340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101395_RS06345	COG1506	peptidase
S101395_RS06360	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S101395_RS06365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S101395_RS06370	COG0367	asparagine synthase
S101395_RS06380	COG0671	phosphoesterase, PA-phosphatase related
S101395_RS06385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S101395_RS06390	COG2267	carboxylic ester hydrolase activity
S101395_RS06400	COG1301	dicarboxylic acid transport
S101395_RS06405	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S101395_RS06410	COG1242	4 iron, 4 sulfur cluster binding
S101395_RS06420	COG1725	Transcriptional regulator
S101395_RS06425	COG1131	(ABC) transporter
S101395_RS06435	COG1136	(ABC) transporter
S101395_RS06440	COG0577	efflux transmembrane transporter activity
S101395_RS06445	COG0109	protoheme IX farnesyltransferase activity
S101395_RS06460	COG2814	Major facilitator Superfamily
S101395_RS06470	COG0495	leucyl-tRNA aminoacylation
S101395_RS06475	COG0346	lactoylglutathione lyase activity
S101395_RS06480	COG0583	DNA-binding transcription factor activity
S101395_RS06490	COG1073	alpha beta
S101395_RS06495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101395_RS06500	COG0395	ABC-type sugar transport system, permease component
S101395_RS06505	COG1653	transport
S101395_RS06515	COG4209	transmembrane transport
S101395_RS06520	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S101395_RS06525	COG1653	transport
S101395_RS06535	COG5578	integral membrane protein
S101395_RS06545	COG0457	Tetratricopeptide repeat
S101395_RS06550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101395_RS06555	COG0471	metal ion transport
S101395_RS06560	COG1053	succinate dehydrogenase
S101395_RS06565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S101395_RS06570	COG2048	Heterodisulfide reductase, subunit B
S101395_RS06590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
S101395_RS06595	COG3395	kinase activity
S101395_RS06600	COG1349	DNA-binding transcription factor activity
S101395_RS06605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S101395_RS06610	COG2081	HI0933 family
S101395_RS06615	COG2244	polysaccharide biosynthetic process
S101395_RS06620	COG1187	pseudouridine synthase activity
S101395_RS06625	COG1349	DNA-binding transcription factor activity
S101395_RS06630	COG2252	PERMEase
S101395_RS06635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101395_RS06640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101395_RS06645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S101395_RS06655	COG1597	lipid kinase activity
S101395_RS06660	COG0510	thiamine kinase activity
S101395_RS06670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S101395_RS06675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101395_RS06680	COG0281	malic enzyme
S101395_RS06685	COG5584	Small secreted protein
S101395_RS06690	COG1363	Peptidase, m42
S101395_RS06700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101395_RS06705	COG4848	Belongs to the UPF0354 family
S101395_RS06710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101395_RS06715	COG1674	ftsk spoiiie
S101395_RS06720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S101395_RS06725	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S101395_RS06730	COG4980	gas vesicle protein
S101395_RS06735	COG3118	belongs to the thioredoxin family
S101395_RS06745	COG1605	Chorismate mutase
S101395_RS06745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S101395_RS06750	COG1609	Transcriptional regulator
S101395_RS06755	COG1609	Transcriptional regulator
S101395_RS06760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S101395_RS06765	COG1360	Flagellar Motor Protein
S101395_RS06770	COG0123	including yeast histone deacetylase and acetoin utilization protein
S101395_RS06775	COG0517	IMP dehydrogenase activity
S101395_RS06780	COG0454	-acetyltransferase
S101395_RS06785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101395_RS06790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101395_RS06795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S101395_RS06800	COG2203	Gaf domain
S101395_RS06800	COG2199	diguanylate cyclase activity
S101395_RS06805	COG1956	GAF domain-containing protein
S101395_RS06810	COG1309	transcriptional regulator
S101395_RS06815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S101395_RS06820	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S101395_RS06825	COG1114	Component of the transport system for branched-chain amino acids
S101395_RS06830	COG1104	cysteine desulfurase activity
S101395_RS06835	COG0301	tRNA thio-modification
S101395_RS06845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101395_RS06855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S101395_RS06860	COG0616	signal peptide processing
S101395_RS06865	COG1714	RDD family
S101395_RS06875	COG3874	Sporulation protein YtfJ
S101395_RS06880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S101395_RS06885	COG0827	DNA restriction-modification system
S101395_RS06890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S101395_RS06895	COG0521	Mo-molybdopterin cofactor biosynthetic process
S101395_RS06900	COG0137	argininosuccinate synthase activity
S101395_RS06905	COG0165	Argininosuccinate lyase
S101395_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS06915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S101395_RS06920	COG1695	Transcriptional regulator
S101395_RS06925	COG4109	DRTGG domain
S101395_RS06935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S101395_RS06955	COG0587	DNA-directed DNA polymerase activity
S101395_RS06960	COG0281	malic enzyme
S101395_RS06965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S101395_RS06970	COG0825	malonyl-CoA metabolic process
S101395_RS06975	COG0205	6-phosphofructokinase activity
S101395_RS06985	COG3030	protein affecting phage T7 exclusion by the F plasmid
S101395_RS06990	COG0628	permease
S101395_RS06995	COG2707	UPF0756 membrane protein
S101395_RS07000	COG0372	Belongs to the citrate synthase family
S101395_RS07005	COG0538	isocitrate dehydrogenase activity
S101395_RS07015	COG0745	RESPONSE REGULATOR receiver
S101395_RS07020	COG5002	protein histidine kinase activity
S101395_RS07025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101395_RS07025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101395_RS07030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S101395_RS07035	COG1971	Probably functions as a manganese efflux pump
S101395_RS07040	COG0237	dephospho-CoA kinase activity
S101395_RS07045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S101395_RS07050	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S101395_RS07060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S101395_RS07070	COG1484	DNA-dependent DNA replication
S101395_RS07075	COG0398	Pfam SNARE associated Golgi protein
S101395_RS07095	COG1011	Hydrolase
S101395_RS07105	COG3275	phosphorelay sensor kinase activity
S101395_RS07110	COG3279	Response regulator of the LytR AlgR family
S101395_RS07115	COG3540	Alkaline phosphatase
S101395_RS07120	COG1380	Effector of murein hydrolase LrgA
S101395_RS07125	COG1346	cytolysis
S101395_RS07130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S101395_RS07135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S101395_RS07140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S101395_RS07145	COG3326	Membrane
S101395_RS07155	COG1363	Peptidase, m42
S101395_RS07160	COG3507	Belongs to the glycosyl hydrolase 43 family
S101395_RS07170	COG1069	ribulokinase activity
S101395_RS07175	COG0235	Class ii aldolase
S101395_RS07180	COG0371	Dehydrogenase
S101395_RS07185	COG1653	transport
S101395_RS07190	COG1175	transmembrane transport
S101395_RS07195	COG0395	ABC-type sugar transport system, permease component
S101395_RS07215	COG3402	PFAM membrane-flanked domain
S101395_RS07220	COG1309	transcriptional regulator
S101395_RS07225	COG1966	Carbon starvation protein
S101395_RS07235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101395_RS07245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S101395_RS07250	COG0072	phenylalanine-tRNA ligase activity
S101395_RS07250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101395_RS07270	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S101395_RS07275	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S101395_RS07280	COG1286	toxin biosynthetic process
S101395_RS07285	COG1796	DNA polymerase
S101395_RS07285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S101395_RS07290	COG1193	negative regulation of DNA recombination
S101395_RS07295	COG3766	membrane
S101395_RS07300	COG0318	PFAM AMP-dependent synthetase and ligase
S101395_RS07305	COG1309	transcriptional regulator
S101395_RS07310	COG1024	Enoyl-CoA hydratase
S101395_RS07315	COG2086	electron transfer activity
S101395_RS07320	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S101395_RS07325	COG3118	belongs to the thioredoxin family
S101395_RS07330	COG0322	excinuclease ABC activity
S101395_RS07340	COG0527	aspartate kinase activity
S101395_RS07345	COG1719	4-vinyl reductase, 4VR
S101395_RS07350	COG2009	succinate dehydrogenase
S101395_RS07355	COG1053	succinate dehydrogenase
S101395_RS07360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S101395_RS07365	COG0824	Thioesterase
S101395_RS07370	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS07375	COG2197	response regulator
S101395_RS07380	COG1846	Transcriptional regulator
S101395_RS07385	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S101395_RS07390	COG3420	alginic acid biosynthetic process
S101395_RS07395	COG5401	PFAM Sporulation and spore germination
S101395_RS07400	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S101395_RS07405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S101395_RS07410	COG0622	Phosphoesterase
S101395_RS07455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101395_RS07465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101395_RS07470	COG0028	Belongs to the TPP enzyme family
S101395_RS07475	COG0440	acetolactate synthase activity
S101395_RS07480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S101395_RS07485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S101395_RS07490	COG0473	3-isopropylmalate dehydrogenase activity
S101395_RS07495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S101395_RS07500	COG0066	3-isopropylmalate dehydratase activity
S101395_RS07505	COG1477	protein flavinylation
S101395_RS07505	COG0457	Tetratricopeptide repeat
S101395_RS07510	COG0544	peptidyl-prolyl cis-trans isomerase activity
S101395_RS07515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S101395_RS07520	COG1067	ATP-dependent peptidase activity
S101395_RS07520	COG0470	DNA polymerase III
S101395_RS07525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S101395_RS07530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S101395_RS07540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S101395_RS07545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S101395_RS07550	COG0181	hydroxymethylbilane synthase activity
S101395_RS07555	COG1587	Uroporphyrinogen-III synthase
S101395_RS07560	COG0113	porphobilinogen synthase activity
S101395_RS07565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S101395_RS07570	COG1388	LysM domain
S101395_RS07575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101395_RS07585	COG0525	valine-tRNA ligase activity
S101395_RS07590	COG0285	dihydrofolate synthase activity
S101395_RS07595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S101395_RS07605	COG0424	maF-like protein
S101395_RS07610	COG2003	Belongs to the UPF0758 family
S101395_RS07615	COG1077	Cell shape determining protein MreB Mrl
S101395_RS07625	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S101395_RS07630	COG0850	regulation of cytokinetic process
S101395_RS07635	COG2894	cell division
S101395_RS07640	COG0640	Transcriptional regulator
S101395_RS07645	COG3832	glyoxalase III activity
S101395_RS07650	COG0739	heme binding
S101395_RS07655	COG1994	Peptidase M50
S101395_RS07660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S101395_RS07665	COG2868	ribosomal protein
S101395_RS07670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S101395_RS07675	COG3290	protein histidine kinase activity
S101395_RS07680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S101395_RS07685	COG4492	Belongs to the UPF0735 family
S101395_RS07690	COG0077	Prephenate dehydratase
S101395_RS07695	COG1827	regulation of RNA biosynthetic process
S101395_RS07700	COG1104	cysteine desulfurase activity
S101395_RS07705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S101395_RS07710	COG0157	Belongs to the NadC ModD family
S101395_RS07720	COG1388	LysM domain
S101395_RS07730	COG0217	transcriptional regulatory protein
S101395_RS07750	COG4195	phage-related replication protein
S101395_RS07755	COG2318	DinB family
S101395_RS07770	COG2112	serine threonine protein kinase
S101395_RS07780	COG0632	four-way junction helicase activity
S101395_RS07785	COG2255	four-way junction helicase activity
S101395_RS07795	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S101395_RS07800	COG0343	queuine tRNA-ribosyltransferase activity
S101395_RS07805	COG1862	Preprotein translocase
S101395_RS07815	COG2323	membrane
S101395_RS07820	COG2244	polysaccharide biosynthetic process
S101395_RS07830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101395_RS07830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101395_RS07835	COG0490	domain, Protein
S101395_RS07840	COG5416	Lipopolysaccharide assembly protein A domain
S101395_RS07845	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S101395_RS07845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S101395_RS07850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101395_RS07855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S101395_RS07860	COG1490	D-aminoacyl-tRNA deacylase activity
S101395_RS07865	COG4991	sh3 domain protein
S101395_RS07865	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101395_RS07865	COG3103	Sh3 type 3 domain protein
S101395_RS07875	COG0124	histidyl-tRNA synthetase
S101395_RS07880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S101395_RS07890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S101395_RS07905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S101395_RS07910	COG1959	2 iron, 2 sulfur cluster binding
S101395_RS07915	COG1104	cysteine desulfurase activity
S101395_RS07920	COG0482	sulfurtransferase activity
S101395_RS07925	COG0457	Tetratricopeptide repeat
S101395_RS07930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S101395_RS07935	COG3881	PFAM PRC-barrel domain
S101395_RS07955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S101395_RS07960	COG4472	Bacterial protein of unknown function (DUF965)
S101395_RS07965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S101395_RS07970	COG3906	Belongs to the UPF0473 family
S101395_RS07975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101395_RS07980	COG4122	O-methyltransferase activity
S101395_RS07985	COG0826	peptidase U32
S101395_RS07990	COG0826	peptidase U32
S101395_RS07995	COG0572	uridine kinase
S101395_RS08000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S101395_RS08005	COG0768	penicillin binding
S101395_RS08020	COG2226	methyltransferase
S101395_RS08025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S101395_RS08030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101395_RS08035	COG0626	cystathionine gamma-synthase activity
S101395_RS08060	COG2226	methyltransferase
S101395_RS08065	COG1404	Belongs to the peptidase S8 family
S101395_RS08075	COG1309	transcriptional regulator
S101395_RS08080	COG2124	cytochrome p450
S101395_RS08080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101395_RS08090	COG2814	Major facilitator Superfamily
S101395_RS08095	COG0583	DNA-binding transcription factor activity
S101395_RS08105	COG1587	Uroporphyrinogen-III synthase
S101395_RS08110	COG1733	regulation of RNA biosynthetic process
S101395_RS08115	COG2814	Major facilitator Superfamily
S101395_RS08120	COG0656	L-ascorbic acid biosynthetic process
S101395_RS08145	COG2205	protein histidine kinase activity
S101395_RS08150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S101395_RS08155	COG2169	Transcriptional regulator
S101395_RS08170	COG2350	Protein conserved in bacteria
S101395_RS08190	COG1525	nuclease
S101395_RS08205	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S101395_RS08205	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S101395_RS08210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS08215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS08220	COG3715	PTS system
S101395_RS08225	COG3716	PTS system mannose fructose sorbose family IID component
S101395_RS08230	COG1621	beta-fructofuranosidase activity
S101395_RS08235	COG0673	inositol 2-dehydrogenase activity
S101395_RS08240	COG1082	Xylose isomerase domain protein TIM barrel
S101395_RS08245	COG4977	sequence-specific DNA binding
S101395_RS08245	COG1917	Cupin 2, conserved barrel domain protein
S101395_RS08250	COG2211	Major facilitator Superfamily
S101395_RS08255	COG3507	Belongs to the glycosyl hydrolase 43 family
S101395_RS08265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101395_RS08270	COG4187	Peptidase family M20/M25/M40
S101395_RS08275	COG0833	amino acid
S101395_RS08285	COG2124	cytochrome p450
S101395_RS08295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101395_RS08310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101395_RS08315	COG1846	Transcriptional regulator
S101395_RS08325	COG0693	protein deglycase activity
S101395_RS08340	COG1263	PTS System
S101395_RS08340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS08340	COG2190	(PTS) system
S101395_RS08370	COG1942	4-Oxalocrotonate Tautomerase
S101395_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS08390	COG1070	Carbohydrate kinase
S101395_RS08395	COG4806	L-rhamnose isomerase
S101395_RS08400	COG0235	Class ii aldolase
S101395_RS08405	COG3254	rhamnose metabolic process
S101395_RS08410	COG2814	Major facilitator Superfamily
S101395_RS08415	COG1454	alcohol dehydrogenase
S101395_RS08420	COG0492	ferredoxin-NADP+ reductase activity
S101395_RS08425	COG1114	Component of the transport system for branched-chain amino acids
S101395_RS08430	COG3409	Peptidoglycan-binding domain 1 protein
S101395_RS08460	COG2197	response regulator
S101395_RS08465	COG4585	Histidine kinase
S101395_RS08470	COG3239	Fatty acid desaturase
S101395_RS08475	COG1733	regulation of RNA biosynthetic process
S101395_RS08480	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
S101395_RS08485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S101395_RS08505	COG0789	Transcriptional regulator
S101395_RS08505	COG4978	Transcriptional regulator
S101395_RS08515	COG1846	Transcriptional regulator
S101395_RS08525	COG5386	Cell surface protein
S101395_RS08530	COG5386	Cell surface protein
S101395_RS08535	COG5386	Cell surface protein
S101395_RS08555	COG4509	Sortase family
S101395_RS08560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101395_RS08565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS08575	COG2329	Antibiotic biosynthesis monooxygenase
S101395_RS08600	COG2390	Transcriptional regulator
S101395_RS08605	COG0133	tryptophan synthase activity
S101395_RS08640	COG2070	2-Nitropropane dioxygenase
S101395_RS08660	COG2807	transmembrane transport
S101395_RS08685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
S101395_RS08690	COG0583	DNA-binding transcription factor activity
S101395_RS08700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101395_RS08710	COG2427	Protein of unknown function (DUF1641)
S101395_RS08715	COG3383	formate dehydrogenase (NAD+) activity
S101395_RS08720	COG5609	conserved protein (DUF2294)
S101395_RS08730	COG2755	lipolytic protein G-D-S-L family
S101395_RS08740	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S101395_RS08750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S101395_RS08755	COG1534	Rna-binding protein
S101395_RS08760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S101395_RS08765	COG1713	HD superfamily hydrolase involved in NAD metabolism
S101395_RS08770	COG0799	negative regulation of ribosome biogenesis
S101395_RS08775	COG2226	methyltransferase
S101395_RS08780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101395_RS08785	COG1555	photosystem II stabilization
S101395_RS08785	COG1596	polysaccharide export
S101395_RS08790	COG2131	deaminase
S101395_RS08795	COG0658	competence protein
S101395_RS08795	COG2333	competence protein COMEC
S101395_RS08805	COG1466	dna polymerase III delta subunit
S101395_RS08810	COG0268	Binds directly to 16S ribosomal RNA
S101395_RS08815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S101395_RS08820	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101395_RS08830	COG0481	GTPase activity
S101395_RS08835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101395_RS08840	COG1420	regulation of RNA biosynthetic process
S101395_RS08845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S101395_RS08850	COG0443	Heat shock 70 kDa protein
S101395_RS08855	COG0484	heat shock protein binding
S101395_RS08860	COG2264	protein methyltransferase activity
S101395_RS08865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S101395_RS08870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S101395_RS08875	COG1247	-acetyltransferase
S101395_RS08880	COG1283	sodium-dependent phosphate transmembrane transporter activity
S101395_RS08885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
S101395_RS08890	COG1610	YqeY-like protein
S101395_RS08895	COG1030	water channel activity
S101395_RS08900	COG4864	UPF0365 protein
S101395_RS08915	COG0561	phosphatase activity
S101395_RS08920	COG1702	phosphate starvation-inducible protein PhoH
S101395_RS08925	COG1480	7TM receptor with intracellular HD hydrolase
S101395_RS08930	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S101395_RS08935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S101395_RS08940	COG0295	cytidine deaminase activity
S101395_RS08945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S101395_RS08955	COG1381	Involved in DNA repair and RecF pathway recombination
S101395_RS08960	COG0752	glycyl-tRNA synthetase alpha subunit
S101395_RS08965	COG0751	glycine-tRNA ligase activity
S101395_RS08970	COG0517	IMP dehydrogenase activity
S101395_RS08975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S101395_RS08980	COG1671	Belongs to the UPF0178 family
S101395_RS08985	COG0358	DNA primase activity
S101395_RS08990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S101395_RS08995	COG2010	Cytochrome c
S101395_RS09015	COG1515	deoxyribonuclease V activity
S101395_RS09020	COG2384	SAM-dependent methyltransferase
S101395_RS09025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S101395_RS09030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S101395_RS09040	COG0513	Belongs to the DEAD box helicase family
S101395_RS09045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S101395_RS09055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101395_RS09060	COG1121	(ABC) transporter
S101395_RS09070	COG0735	belongs to the Fur family
S101395_RS09075	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
S101395_RS09080	COG4709	membrane
S101395_RS09085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S101395_RS09090	COG1388	LysM domain
S101395_RS09095	COG5521	maltodextrose utilization protein MalA
S101395_RS09100	COG2839	Protein conserved in bacteria
S101395_RS09105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S101395_RS09110	COG0477	Major facilitator Superfamily
S101395_RS09115	COG0768	penicillin binding
S101395_RS09120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S101395_RS09125	COG0573	inorganic phosphate transmembrane transporter activity
S101395_RS09130	COG0581	inorganic phosphate transmembrane transporter activity
S101395_RS09135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101395_RS09140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101395_RS09145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101395_RS09170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S101395_RS09180	COG0457	Tetratricopeptide repeat
S101395_RS09180	COG0705	Rhomboid family
S101395_RS09185	COG0697	spore germination
S101395_RS09190	COG4483	Protein conserved in bacteria
S101395_RS09195	COG1940	carbohydrate kinase activity
S101395_RS09200	COG1368	sulfuric ester hydrolase activity
S101395_RS09205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101395_RS09210	COG2866	Carboxypeptidase
S101395_RS09220	COG0011	TIGRFAM Protein of
S101395_RS09230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101395_RS09240	COG1393	Belongs to the ArsC family
S101395_RS09250	COG1366	Belongs to the anti-sigma-factor antagonist family
S101395_RS09255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S101395_RS09260	COG1459	type II secretion system
S101395_RS09280	COG2856	Zn peptidase
S101395_RS09285	COG1396	sequence-specific DNA binding
S101395_RS09330	COG5377	YqaJ viral recombinase family
S101395_RS09335	COG3723	Recombinational DNA repair protein, rece pathway
S101395_RS09350	COG0305	Participates in initiation and elongation during chromosome replication
S101395_RS09365	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
S101395_RS09400	COG0457	Tetratricopeptide repeat
S101395_RS09405	COG5444	nuclease activity
S101395_RS09445	COG1783	phage Terminase large subunit
S101395_RS09450	COG5518	Phage portal protein
S101395_RS09455	COG2369	cell adhesion
S101395_RS09465	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S101395_RS09470	COG4653	Phage capsid family
S101395_RS09525	COG5280	Phage tail tape measure protein TP901
S101395_RS09525	COG3953	SLT domain
S101395_RS09525	COG5280	Phage tail tape measure protein TP901
S101395_RS09525	COG3953	SLT domain
S101395_RS09530	COG1652	LysM domain
S101395_RS09535	COG4193	domain, Protein
S101395_RS09545	COG3628	GPW Gp25 family protein
S101395_RS09550	COG3299	homolog of phage Mu protein gp47
S101395_RS09555	COG3778	Protein conserved in bacteria
S101395_RS09580	COG4824	toxin secretion phage lysis holin
S101395_RS09630	COG4537	Required for transformation and DNA binding
S101395_RS09635	COG4970	Tfp pilus assembly protein FimT
S101395_RS09645	COG4940	Competence protein ComGF
S101395_RS09670	COG0681	Belongs to the peptidase S26 family
S101395_RS09695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S101395_RS09700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S101395_RS09705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101395_RS09710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101395_RS09715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101395_RS09720	COG0095	Lipoate-protein ligase
S101395_RS09725	COG1321	iron dependent repressor
S101395_RS09730	COG1752	Esterase of the alpha-beta hydrolase superfamily
S101395_RS09740	COG3872	metal-dependent enzyme
S101395_RS09750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S101395_RS09755	COG0006	proline dipeptidase activity
S101395_RS09760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S101395_RS09770	COG3854	ATPases associated with a variety of cellular activities
S101395_RS09810	COG0511	ligase activity, forming carbon-carbon bonds
S101395_RS09815	COG0439	Biotin carboxylase
S101395_RS09820	COG1302	Protein conserved in bacteria
S101395_RS09825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101395_RS09830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S101395_RS09835	COG1570	exodeoxyribonuclease VII activity
S101395_RS09840	COG1722	exodeoxyribonuclease VII activity
S101395_RS09845	COG0142	geranyltranstransferase activity
S101395_RS09850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S101395_RS09855	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S101395_RS09860	COG1438	arginine binding
S101395_RS09865	COG0497	DNA recombination
S101395_RS09870	COG0750	zinc metalloprotease
S101395_RS09880	COG0745	RESPONSE REGULATOR receiver
S101395_RS09900	COG1619	proteins homologs of microcin C7 resistance protein MccF
S101395_RS09915	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101395_RS09920	COG0584	glycerophosphoryl diester phosphodiesterase
S101395_RS09930	COG3829	transcription factor binding
S101395_RS09930	COG3290	protein histidine kinase activity
S101395_RS09935	COG0280	phosphate acetyltransferase
S101395_RS09945	COG3426	butyrate kinase activity
S101395_RS09950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101395_RS09955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101395_RS09960	COG0022	dehydrogenase e1 component
S101395_RS09965	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101395_RS09970	COG1597	lipid kinase activity
S101395_RS09980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101395_RS09985	COG0765	amino acid transport
S101395_RS09990	COG1126	abc transporter atp-binding protein
S101395_RS09995	COG4129	membrane
S101395_RS10000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S101395_RS10005	COG2195	Cleaves the N-terminal amino acid of tripeptides
S101395_RS10015	COG0706	membrane insertase activity
S101395_RS10025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101395_RS10030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S101395_RS10035	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS10040	COG1785	Belongs to the alkaline phosphatase family
S101395_RS10045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101395_RS10050	COG1447	Phosphotransferase system cellobiose-specific component IIA
S101395_RS10055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101395_RS10060	COG2723	6-phospho-beta-galactosidase activity
S101395_RS10065	COG2188	Transcriptional regulator
S101395_RS10070	COG2358	TRAP transporter, solute receptor (TAXI family
S101395_RS10085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S101395_RS10090	COG1234	tRNA 3'-trailer cleavage
S101395_RS10095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
S101395_RS10100	COG0596	Alpha beta hydrolase
S101395_RS10105	COG1902	pentaerythritol trinitrate reductase activity
S101395_RS10110	COG4187	Peptidase family M20/M25/M40
S101395_RS10115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101395_RS10120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101395_RS10125	COG0300	oxidoreductase activity
S101395_RS10130	COG4195	phage-related replication protein
S101395_RS10145	COG2814	Major facilitator Superfamily
S101395_RS10150	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S101395_RS10165	COG2205	protein histidine kinase activity
S101395_RS10190	COG1131	(ABC) transporter
S101395_RS10200	COG1072	(Pantothenic acid kinase))
S101395_RS10205	COG0346	lactoylglutathione lyase activity
S101395_RS10210	COG2211	Major facilitator Superfamily
S101395_RS10225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101395_RS10240	COG0534	Mate efflux family protein
S101395_RS10250	COG0444	Belongs to the ABC transporter superfamily
S101395_RS10255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101395_RS10260	COG0601	transmembrane transport
S101395_RS10265	COG0747	negative chemotaxis
S101395_RS10275	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S101395_RS10285	COG0456	acetyltransferase
S101395_RS10290	COG2329	Antibiotic biosynthesis monooxygenase
S101395_RS10295	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S101395_RS10295	COG0456	acetyltransferase
S101395_RS10305	COG4918	Iron-sulphur cluster biosynthesis
S101395_RS10315	COG1073	alpha beta
S101395_RS10325	COG0667	Aldo Keto reductase
S101395_RS10335	COG1309	transcriptional regulator
S101395_RS10345	COG0494	nUDIX hydrolase
S101395_RS10350	COG1379	DNA repair
S101395_RS10355	COG2153	protein acetylation
S101395_RS10370	COG1953	Uracil, thiamine, allantoin
S101395_RS10380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101395_RS10385	COG1300	Membrane
S101395_RS10390	COG0735	belongs to the Fur family
S101395_RS10400	COG4974	Belongs to the 'phage' integrase family
S101395_RS10405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S101395_RS10410	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S101395_RS10415	COG1686	Belongs to the peptidase S11 family
S101395_RS10450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101395_RS10465	COG0697	spore germination
S101395_RS10480	COG0019	diaminopimelate decarboxylase activity
S101395_RS10485	COG4195	phage-related replication protein
S101395_RS10490	COG4086	secreted protein
S101395_RS10495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S101395_RS10500	COG0457	Tetratricopeptide repeat
S101395_RS10520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101395_RS10520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101395_RS10525	COG0307	riboflavin synthase, alpha
S101395_RS10530	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101395_RS10530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101395_RS10535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S101395_RS10540	COG0456	acetyltransferase
S101395_RS10545	COG1547	Domain of unknown function (DUF309)
S101395_RS10555	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S101395_RS10560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S101395_RS10570	COG1686	Belongs to the peptidase S11 family
S101395_RS10575	COG2715	membrane protein required for spore maturation
S101395_RS10580	COG0700	Nucleoside recognition
S101395_RS10585	COG1187	pseudouridine synthase activity
S101395_RS10590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101395_RS10595	COG1333	cytochrome c biogenesis protein
S101395_RS10600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S101395_RS10605	COG0745	RESPONSE REGULATOR receiver
S101395_RS10610	COG5002	protein histidine kinase activity
S101395_RS10615	COG0745	RESPONSE REGULATOR receiver
S101395_RS10620	COG5002	protein histidine kinase activity
S101395_RS10635	COG1316	TRANSCRIPTIONal
S101395_RS10640	COG1595	DNA-templated transcription, initiation
S101395_RS10650	COG0739	heme binding
S101395_RS10655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S101395_RS10660	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S101395_RS10665	COG1141	Ferredoxin
S101395_RS10670	COG4955	Helix-turn-helix domain
S101395_RS10675	COG0514	ATP-dependent DNA helicase (RecQ)
S101395_RS10680	COG1266	CAAX protease self-immunity
S101395_RS10685	COG1388	LysM domain
S101395_RS10695	COG1408	metallophosphoesterase
S101395_RS10700	COG4862	establishment of competence for transformation
S101395_RS10705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101395_RS10710	COG0492	ferredoxin-NADP+ reductase activity
S101395_RS10720	COG2339	peptidase activity
S101395_RS10725	COG3773	Cell wall hydrolase
S101395_RS10725	COG3409	Peptidoglycan-binding domain 1 protein
S101395_RS10730	COG2959	enzyme of heme biosynthesis
S101395_RS10740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S101395_RS10745	COG0539	negative regulation of cytoplasmic translation
S101395_RS10750	COG1304	FMN binding
S101395_RS10775	COG1160	GTP binding
S101395_RS10780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S101395_RS10800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S101395_RS10805	COG0776	regulation of translation
S101395_RS10810	COG0302	gtp cyclohydrolase
S101395_RS10820	COG0142	geranyltranstransferase activity
S101395_RS10825	COG2226	methyltransferase
S101395_RS10830	COG0142	geranyltranstransferase activity
S101395_RS10835	COG0105	UTP biosynthetic process
S101395_RS10840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S101395_RS10845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S101395_RS10850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S101395_RS10855	COG4401	Chorismate mutase type I
S101395_RS10860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S101395_RS10865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S101395_RS10870	COG0134	indole-3-glycerol-phosphate synthase activity
S101395_RS10875	COG0135	phosphoribosylanthranilate isomerase activity
S101395_RS10880	COG0133	tryptophan synthase activity
S101395_RS10885	COG0159	tryptophan synthase activity
S101395_RS10890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S101395_RS10895	COG0287	Prephenate dehydrogenase
S101395_RS10900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S101395_RS10905	COG0457	Tetratricopeptide repeat
S101395_RS10910	COG5582	Belongs to the UPF0302 family
S101395_RS10920	COG0723	plastoquinol--plastocyanin reductase activity
S101395_RS10925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101395_RS10930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101395_RS10930	COG2010	Cytochrome c
S101395_RS10935	COG4347	Protein of unknown function (DUF1405)
S101395_RS10945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101395_RS10950	COG1694	Mazg nucleotide pyrophosphohydrolase
S101395_RS10955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S101395_RS10960	COG1803	Methylglyoxal synthase
S101395_RS10965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101395_RS10970	COG0438	transferase activity, transferring glycosyl groups
S101395_RS10975	COG0617	tRNA 3'-terminal CCA addition
S101395_RS10985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S101395_RS10990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S101395_RS10995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S101395_RS11000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S101395_RS11000	COG1199	ATP-dependent helicase activity
S101395_RS11010	COG5353	protein conserved in bacteria
S101395_RS11015	COG0436	Aminotransferase
S101395_RS11020	COG0017	Asparaginyl-tRNA synthetase
S101395_RS11030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S101395_RS11040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101395_RS11040	COG4499	WXG100 protein secretion system (Wss), protein YukC
S101395_RS11045	COG3331	DNA recombination
S101395_RS11080	COG0071	Belongs to the small heat shock protein (HSP20) family
S101395_RS11090	COG2190	(PTS) system
S101395_RS11095	COG1205	dead DEAH box helicase
S101395_RS11095	COG1111	helicase
S101395_RS11100	COG3359	exonuclease
S101395_RS11110	COG4474	Belongs to the UPF0398 family
S101395_RS11115	COG3599	regulation of cell shape
S101395_RS11125	COG0116	Belongs to the methyltransferase superfamily
S101395_RS11140	COG1199	ATP-dependent helicase activity
S101395_RS11145	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S101395_RS11150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101395_RS11155	COG2233	PERMEase
S101395_RS11160	COG1247	-acetyltransferase
S101395_RS11165	COG3424	synthase
S101395_RS11170	COG1755	Isoprenylcysteine carboxyl methyltransferase
S101395_RS11180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S101395_RS11195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101395_RS11205	COG0328	RNA-DNA hybrid ribonuclease activity
S101395_RS11210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
S101395_RS11215	COG0328	RNA-DNA hybrid ribonuclease activity
S101395_RS11235	COG1278	Cold shock
S101395_RS11245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101395_RS11250	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S101395_RS11255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
S101395_RS11260	COG0386	Belongs to the glutathione peroxidase family
S101395_RS11265	COG1418	mRNA catabolic process
S101395_RS11270	COG1413	lyase activity
S101395_RS11275	COG0129	dihydroxy-acid dehydratase activity
S101395_RS11285	COG2521	methyltransferase
S101395_RS11285	COG2136	Putative SAM-dependent methyltransferase
S101395_RS11295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S101395_RS11300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S101395_RS11305	COG0204	Acyl-transferase
S101395_RS11310	COG1272	protein, Hemolysin III
S101395_RS11315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S101395_RS11320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S101395_RS11330	COG1307	EDD domain protein, DegV family
S101395_RS11335	COG1999	signal sequence binding
S101395_RS11340	COG2755	lipolytic protein G-D-S-L family
S101395_RS11345	COG4698	Protein conserved in bacteria
S101395_RS11365	COG0534	Mate efflux family protein
S101395_RS11375	COG1846	Transcriptional regulator
S101395_RS11380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101395_RS11380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101395_RS11385	COG0456	acetyltransferase
S101395_RS11400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101395_RS11405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S101395_RS11410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S101395_RS11415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101395_RS11420	COG0456	acetyltransferase
S101395_RS11425	COG1509	lysine 2,3-aminomutase activity
S101395_RS11435	COG4479	Belongs to the UPF0346 family
S101395_RS11455	COG0671	phosphoesterase, PA-phosphatase related
S101395_RS11475	COG0701	Predicted permease
S101395_RS11480	COG0813	purine-nucleoside phosphorylase activity
S101395_RS11495	COG2226	methyltransferase
S101395_RS11500	COG3409	Peptidoglycan-binding domain 1 protein
S101395_RS11500	COG0793	Belongs to the peptidase S41A family
S101395_RS11505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101395_RS11515	COG0346	lactoylglutathione lyase activity
S101395_RS11520	COG0400	carboxylic ester hydrolase activity
S101395_RS11525	COG0778	Nitroreductase
S101395_RS11530	COG1733	regulation of RNA biosynthetic process
S101395_RS11535	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS11545	COG4305	rare lipoprotein A
S101395_RS11555	COG2962	Rard protein
S101395_RS11565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101395_RS11570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101395_RS11575	COG0534	Mate efflux family protein
S101395_RS11580	COG1388	LysM domain
S101395_RS11580	COG0791	NLP P60 protein
S101395_RS11585	COG2032	superoxide dismutase activity
S101395_RS11590	COG0714	Associated with various cellular activities
S101395_RS11595	COG4548	von Willebrand factor, type A
S101395_RS11600	COG0567	Dehydrogenase, E1 component
S101395_RS11605	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101395_RS11610	COG0385	Bile acid
S101395_RS11620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S101395_RS11650	COG1012	belongs to the aldehyde dehydrogenase family
S101395_RS11665	COG2140	Oxalate decarboxylase
S101395_RS11670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101395_RS11675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S101395_RS11715	COG4555	ABC transporter
S101395_RS11730	COG0602	queuosine metabolic process
S101395_RS11735	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S101395_RS11740	COG2318	DinB family
S101395_RS11745	COG0405	Gamma-glutamyltransferase
S101395_RS11760	COG1309	transcriptional regulator
S101395_RS11770	COG0574	Belongs to the PEP-utilizing enzyme family
S101395_RS11770	COG3848	Pyruvate phosphate dikinase
S101395_RS11775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S101395_RS11785	COG1280	lysine exporter protein (LysE YggA)
S101395_RS11800	COG1357	PFAM Pentapeptide repeats (8 copies)
S101395_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS11840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101395_RS11855	COG2323	membrane
S101395_RS11885	COG1660	Displays ATPase and GTPase activities
S101395_RS11890	COG0789	Transcriptional regulator
S101395_RS11895	COG4221	oxidoreductase activity
S101395_RS11925	COG5646	InterPro IPR014922
S101395_RS11965	COG0514	ATP-dependent DNA helicase (RecQ)
S101395_RS11970	COG3584	3D domain protein
S101395_RS11970	COG1388	LysM domain
S101395_RS11975	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101395_RS11985	COG2322	membrane
S101395_RS12005	COG1086	Polysaccharide biosynthesis protein
S101395_RS12010	COG0741	lytic transglycosylase activity
S101395_RS12015	COG0531	amino acid
S101395_RS12025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101395_RS12030	COG0640	Transcriptional regulator
S101395_RS12040	COG2378	regulation of single-species biofilm formation
S101395_RS12050	COG3708	Transcriptional regulator
S101395_RS12055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101395_RS12060	COG1309	transcriptional regulator
S101395_RS12075	COG1309	transcriptional regulator
S101395_RS12085	COG1404	Belongs to the peptidase S8 family
S101395_RS12095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101395_RS12100	COG0840	transmembrane signaling receptor activity
S101395_RS12110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S101395_RS12115	COG0697	spore germination
S101395_RS12125	COG0488	(ABC) transporter
S101395_RS12135	COG0697	spore germination
S101395_RS12140	COG0531	amino acid
S101395_RS12145	COG0531	amino acid
S101395_RS12160	COG2814	Major facilitator Superfamily
S101395_RS12165	COG1846	Transcriptional regulator
S101395_RS12170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101395_RS12175	COG0243	molybdopterin cofactor binding
S101395_RS12180	COG0477	Major facilitator Superfamily
S101395_RS12190	COG0300	oxidoreductase activity
S101395_RS12200	COG3540	Alkaline phosphatase
S101395_RS12205	COG1132	(ABC) transporter
S101395_RS12235	COG0583	DNA-binding transcription factor activity
S101395_RS12240	COG0069	glutamate synthase activity
S101395_RS12240	COG0067	glutamate synthase
S101395_RS12240	COG0070	glutamate synthase
S101395_RS12245	COG0493	'glutamate synthase
S101395_RS12265	COG0463	Glycosyl transferase, family 2
S101395_RS12270	COG2814	Major facilitator Superfamily
S101395_RS12275	COG4948	Mandelate Racemase Muconate Lactonizing
S101395_RS12280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101395_RS12285	COG1809	phosphosulfolactate synthase activity
S101395_RS12290	COG0175	sulfate reduction
S101395_RS12300	COG2046	Belongs to the sulfate adenylyltransferase family
S101395_RS12305	COG0529	Catalyzes the synthesis of activated sulfate
S101395_RS12310	COG2323	membrane
S101395_RS12315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101395_RS12320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101395_RS12325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S101395_RS12330	COG1960	acyl-CoA dehydrogenase activity
S101395_RS12335	COG0318	PFAM AMP-dependent synthetase and ligase
S101395_RS12340	COG0439	Biotin carboxylase
S101395_RS12345	COG0511	ligase activity, forming carbon-carbon bonds
S101395_RS12350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S101395_RS12355	COG1024	Enoyl-CoA hydratase
S101395_RS12360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S101395_RS12365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101395_RS12375	COG0166	Belongs to the GPI family
S101395_RS12390	COG1252	NADH dehydrogenase
S101395_RS12395	COG2027	D-alanyl-D-alanine carboxypeptidase
S101395_RS12400	COG1882	Formate acetyltransferase
S101395_RS12405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
S101395_RS12410	COG2404	hydrolase activity, acting on ester bonds
S101395_RS12415	COG1649	PFAM Uncharacterised BCR, COG1649
S101395_RS12430	COG0640	Transcriptional regulator
S101395_RS12435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S101395_RS12440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101395_RS12450	COG1725	Transcriptional regulator
S101395_RS12480	COG2814	Major facilitator Superfamily
S101395_RS12485	COG0785	Cytochrome C biogenesis protein
S101395_RS12490	COG1309	transcriptional regulator
S101395_RS12500	COG2076	Multidrug Resistance protein
S101395_RS12505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS12505	COG3711	transcriptional antiterminator
S101395_RS12510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101395_RS12510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101395_RS12510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS12515	COG1482	cell wall glycoprotein biosynthetic process
S101395_RS12520	COG1595	DNA-templated transcription, initiation
S101395_RS12525	COG0667	Aldo Keto reductase
S101395_RS12535	COG1960	acyl-CoA dehydrogenase activity
S101395_RS12540	COG2084	Dehydrogenase
S101395_RS12545	COG1012	belongs to the aldehyde dehydrogenase family
S101395_RS12550	COG1024	Enoyl-CoA hydratase
S101395_RS12575	COG1017	nitric oxide dioxygenase activity
S101395_RS12575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S101395_RS12580	COG2223	nitrite transmembrane transporter activity
S101395_RS12585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
S101395_RS12590	COG1140	nitrate reductase beta subunit
S101395_RS12595	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
S101395_RS12600	COG2181	nitrate reductase activity
S101395_RS12610	COG1125	glycine betaine transport
S101395_RS12610	COG0517	IMP dehydrogenase activity
S101395_RS12615	COG1174	glycine betaine transport
S101395_RS12625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101395_RS12630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
S101395_RS12635	COG1687	branched-chain amino acid
S101395_RS12645	COG0457	Tetratricopeptide repeat
S101395_RS12660	COG5609	conserved protein (DUF2294)
S101395_RS12665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S101395_RS12670	COG3002	Belongs to the UPF0753 family
S101395_RS12700	COG1073	alpha beta
S101395_RS12705	COG1473	amidohydrolase
S101395_RS12730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101395_RS12735	COG1116	anion transmembrane transporter activity
S101395_RS12740	COG5444	nuclease activity
S101395_RS12745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101395_RS12755	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
S101395_RS12765	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
S101395_RS12785	COG2223	nitrite transmembrane transporter activity
S101395_RS12790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101395_RS12800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101395_RS12805	COG0535	radical SAM domain protein
S101395_RS12820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
S101395_RS12825	COG1140	nitrate reductase beta subunit
S101395_RS12830	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
S101395_RS12835	COG2181	nitrate reductase activity
S101395_RS12845	COG1115	amino acid carrier protein
S101395_RS12870	COG2160	L-arabinose isomerase activity
S101395_RS12885	COG1609	Transcriptional regulator
S101395_RS12890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101395_RS12895	COG0187	DNA topoisomerase II activity
S101395_RS12900	COG1832	CoA-binding protein
S101395_RS12905	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S101395_RS12910	COG4841	protein insertion into membrane
S101395_RS12920	COG0824	Thioesterase
S101395_RS12940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101395_RS12945	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S101395_RS12960	COG0071	Belongs to the small heat shock protein (HSP20) family
S101395_RS12970	COG4846	Membrane protein involved in cytochrome C biogenesis
S101395_RS12975	COG2201	protein-glutamate methylesterase activity
S101395_RS12980	COG0785	Cytochrome C biogenesis protein
S101395_RS12990	COG3763	UPF0154 protein
S101395_RS13000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S101395_RS13005	COG4224	UPF0291 protein
S101395_RS13010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S101395_RS13015	COG1388	LysM domain
S101395_RS13020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S101395_RS13025	COG5434	Belongs to the glycosyl hydrolase 28 family
S101395_RS13080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101395_RS13085	COG2076	Multidrug Resistance protein
S101395_RS13090	COG2076	Multidrug Resistance protein
S101395_RS13095	COG1309	transcriptional regulator
S101395_RS13100	COG0457	Tetratricopeptide repeat
S101395_RS13105	COG2814	Major facilitator Superfamily
S101395_RS13125	COG4989	oxidoreductase activity
S101395_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS13165	COG0457	Tetratricopeptide repeat
S101395_RS13180	COG1064	alcohol dehydrogenase
S101395_RS13190	COG0756	dUTP diphosphatase activity
S101395_RS13205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101395_RS13220	COG0475	glutathione-regulated potassium exporter activity
S101395_RS13225	COG0490	domain, Protein
S101395_RS13270	COG0457	Tetratricopeptide repeat
S101395_RS13275	COG2814	Major facilitator Superfamily
S101395_RS13285	COG0574	Belongs to the PEP-utilizing enzyme family
S101395_RS13285	COG3848	Pyruvate phosphate dikinase
S101395_RS13300	COG0457	Tetratricopeptide repeat
S101395_RS13305	COG2814	Major facilitator Superfamily
S101395_RS13320	COG3716	PTS system mannose fructose sorbose family IID component
S101395_RS13325	COG3715	PTS system
S101395_RS13370	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S101395_RS13390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S101395_RS13520	COG0174	glutamine synthetase
S101395_RS13525	COG0789	Transcriptional regulator
S101395_RS13530	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S101395_RS13535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S101395_RS13540	COG0464	growth
S101395_RS13550	COG3331	DNA recombination
S101395_RS13570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S101395_RS13600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S101395_RS13610	COG0756	dUTP diphosphatase activity
S101395_RS13630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101395_RS13635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101395_RS13645	COG1372	Participates in initiation and elongation during chromosome replication
S101395_RS13645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101395_RS13650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101395_RS13655	COG1780	Probably involved in ribonucleotide reductase function
S101395_RS13735	COG0587	DNA-directed DNA polymerase activity
S101395_RS13745	COG0587	DNA-directed DNA polymerase activity
S101395_RS13750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S101395_RS13755	COG0358	DNA primase activity
S101395_RS13760	COG0305	Participates in initiation and elongation during chromosome replication
S101395_RS13770	COG2887	Belongs to the helicase family. UvrD subfamily
S101395_RS13785	COG1404	Belongs to the peptidase S8 family
S101395_RS13845	COG1793	dna ligase
S101395_RS13900	COG4474	Belongs to the UPF0398 family
S101395_RS13955	COG0582	viral genome integration into host DNA
S101395_RS13995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S101395_RS14040	COG3655	Transcriptional regulator
S101395_RS14140	COG1121	(ABC) transporter
S101395_RS14145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S101395_RS14200	COG4373	Mu-like prophage FluMu protein gp28
S101395_RS14295	COG0582	viral genome integration into host DNA
S101395_RS14360	COG0741	lytic transglycosylase activity
S101395_RS14360	COG0739	heme binding
S101395_RS14360	COG1196	nuclear chromosome segregation
S101395_RS14365	COG0741	lytic transglycosylase activity
S101395_RS14365	COG1196	nuclear chromosome segregation
S101395_RS14365	COG0739	heme binding
S101395_RS14370	COG1196	nuclear chromosome segregation
S101395_RS14370	COG0741	lytic transglycosylase activity
S101395_RS14370	COG0739	heme binding
S101395_RS14380	COG2433	Pfam Transposase IS66
S101395_RS14390	COG5434	Belongs to the glycosyl hydrolase 28 family
S101395_RS14395	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101395_RS14415	COG0457	Tetratricopeptide repeat
S101395_RS14445	COG5444	nuclease activity
S101395_RS14450	COG4282	regulation of fungal-type cell wall biogenesis
S101395_RS14475	COG0464	growth
S101395_RS14500	COG0697	spore germination
S101395_RS14505	COG1802	Transcriptional regulator
S101395_RS14510	COG4112	unkown
S101395_RS14515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101395_RS14520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101395_RS14525	COG1780	Probably involved in ribonucleotide reductase function
S101395_RS14535	COG1923	regulation of RNA biosynthetic process
S101395_RS14540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S101395_RS14555	COG2076	Multidrug Resistance protein
S101395_RS14565	COG1764	response to oxidative stress
S101395_RS14575	COG0702	epimerase
S101395_RS14580	COG3631	Ketosteroid isomerase-related protein
S101395_RS14585	COG1309	transcriptional regulator
S101395_RS14590	COG3858	chitin binding
S101395_RS14590	COG1388	LysM domain
S101395_RS14600	COG5577	PFAM Coat F domain
S101395_RS14605	COG0531	amino acid
S101395_RS14610	COG1819	glycosyl
S101395_RS14615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101395_RS14620	COG0398	Pfam SNARE associated Golgi protein
S101395_RS14625	COG0393	Putative heavy-metal-binding
S101395_RS14665	COG2814	Major facilitator Superfamily
S101395_RS14670	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
S101395_RS14670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101395_RS14675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101395_RS14680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101395_RS14685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101395_RS14695	COG3263	regulation of cellular component size
S101395_RS14700	COG3619	membrane
S101395_RS14710	COG0346	lactoylglutathione lyase activity
S101395_RS14715	COG2135	peptidase activity
S101395_RS14720	COG1231	oxidoreductase activity
S101395_RS14795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S101395_RS14810	COG5444	nuclease activity
S101395_RS14815	COG0457	Tetratricopeptide repeat
S101395_RS14845	COG4282	regulation of fungal-type cell wall biogenesis
S101395_RS14900	COG1124	(ABC) transporter
S101395_RS14905	COG0444	Belongs to the ABC transporter superfamily
S101395_RS14910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101395_RS14915	COG0601	transmembrane transport
S101395_RS14920	COG0747	negative chemotaxis
S101395_RS14940	COG0523	cobalamin synthesis protein
S101395_RS14950	COG3411	Ferredoxin
S101395_RS14955	COG0523	cobalamin synthesis protein
S101395_RS14960	COG0822	iron-sulfur transferase activity
S101395_RS14975	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
S101395_RS14980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S101395_RS14985	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S101395_RS14995	COG4550	Control of competence regulator ComK, YlbF/YmcA
S101395_RS15000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S101395_RS15005	COG0156	8-amino-7-oxononanoate synthase activity
S101395_RS15010	COG1063	alcohol dehydrogenase
S101395_RS15020	COG2359	stage V sporulation protein S
S101395_RS15030	COG1418	mRNA catabolic process
S101395_RS15040	COG1058	Belongs to the CinA family
S101395_RS15040	COG1546	Belongs to the CinA family
S101395_RS15045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S101395_RS15050	COG1426	Protein conserved in bacteria
S101395_RS15065	COG0300	oxidoreductase activity
S101395_RS15070	COG0612	Peptidase, M16
S101395_RS15075	COG0612	Peptidase, M16
S101395_RS15085	COG2188	Transcriptional regulator
S101395_RS15090	COG1674	ftsk spoiiie
S101395_RS15090	COG4980	gas vesicle protein
S101395_RS15100	COG0740	serine-type endopeptidase activity
S101395_RS15105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S101395_RS15115	COG0527	aspartate kinase activity
S101395_RS15125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101395_RS15130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101395_RS15135	COG1873	PFAM PRC-barrel domain
S101395_RS15140	COG0612	Peptidase, M16
S101395_RS15145	COG0726	polysaccharide deacetylase
S101395_RS15150	COG1185	polyribonucleotide nucleotidyltransferase activity
S101395_RS15155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S101395_RS15160	COG0196	riboflavin kinase activity
S101395_RS15165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S101395_RS15170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S101395_RS15175	COG1550	Protein conserved in bacteria
S101395_RS15180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S101395_RS15185	COG1358	cellular component organization or biogenesis
S101395_RS15190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S101395_RS15195	COG0195	Participates in both transcription termination and antitermination
S101395_RS15200	COG0779	Required for maturation of 30S ribosomal subunits
S101395_RS15230	COG2176	DNA-directed DNA polymerase activity
S101395_RS15235	COG0442	prolyl-tRNA aminoacylation
S101395_RS15240	COG0750	zinc metalloprotease
S101395_RS15245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S101395_RS15250	COG4589	Belongs to the CDS family
S101395_RS15255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S101395_RS15260	COG0233	cytoplasmic translational termination
S101395_RS15265	COG0528	UMP kinase activity
S101395_RS15270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S101395_RS15275	COG0052	Belongs to the universal ribosomal protein uS2 family
S101395_RS15285	COG1191	sigma factor activity
S101395_RS15290	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S101395_RS15295	COG1776	CheC inhibitor of MCP methylation
S101395_RS15300	COG0835	chemotaxis
S101395_RS15305	COG2198	Histidine kinase
S101395_RS15305	COG0643	Histidine kinase
S101395_RS15310	COG2201	protein-glutamate methylesterase activity
S101395_RS15315	COG0455	bacterial-type flagellum organization
S101395_RS15320	COG1419	protein localization to endoplasmic reticulum
S101395_RS15325	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S101395_RS15330	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S101395_RS15335	COG1684	flagellar biosynthetic protein fliR
S101395_RS15340	COG1987	bacterial-type flagellum assembly
S101395_RS15345	COG1338	Plays a role in the flagellum-specific transport system
S101395_RS15350	COG3190	flagellar
S101395_RS15355	COG2201	protein-glutamate methylesterase activity
S101395_RS15360	COG1776	CheC inhibitor of MCP methylation
S101395_RS15360	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101395_RS15365	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101395_RS15370	COG1580	Controls the rotational direction of flagella during chemotaxis
S101395_RS15375	COG1582	Flagellar protein (FlbD)
S101395_RS15380	COG4786	Flagellar basal body rod
S101395_RS15385	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S101395_RS15390	COG3144	bacterial-type flagellum assembly
S101395_RS15405	COG1157	protein secretion by the type III secretion system
S101395_RS15410	COG1317	bacterial-type flagellum organization
S101395_RS15415	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101395_RS15420	COG1766	The M ring may be actively involved in energy transduction
S101395_RS15425	COG1677	Flagellar hook-basal body complex protein FliE
S101395_RS15430	COG1558	bacterial-type flagellum-dependent cell motility
S101395_RS15435	COG1815	bacterial-type flagellum-dependent cell motility
S101395_RS15440	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S101395_RS15445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S101395_RS15450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S101395_RS15455	COG4974	Belongs to the 'phage' integrase family
S101395_RS15460	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S101395_RS15465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101395_RS15470	COG0758	DNA mediated transformation
S101395_RS15475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S101395_RS15480	COG0045	succinate-CoA ligase (ADP-forming) activity
S101395_RS15485	COG2257	FlhB HrpN YscU SpaS Family
S101395_RS15495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S101395_RS15500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S101395_RS15505	COG0335	large ribosomal subunit rRNA binding
S101395_RS15510	COG0336	Belongs to the RNA methyltransferase TrmD family
S101395_RS15515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S101395_RS15525	COG1837	Belongs to the UPF0109 family
S101395_RS15530	COG0228	four-way junction DNA binding
S101395_RS15535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S101395_RS15540	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S101395_RS15545	COG0552	protein localization to endoplasmic reticulum
S101395_RS15550	COG1196	nuclear chromosome segregation
S101395_RS15555	COG0571	ribonuclease III activity
S101395_RS15560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101395_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS15570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S101395_RS15575	COG0416	fatty acid biosynthetic process
S101395_RS15580	COG1349	DNA-binding transcription factor activity
S101395_RS15585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S101395_RS15590	COG1760	l-serine dehydratase
S101395_RS15595	COG1760	l-serine dehydratase
S101395_RS15600	COG1461	Dihydroxyacetone kinase
S101395_RS15605	COG1302	Protein conserved in bacteria
S101395_RS15610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S101395_RS15620	COG1564	THIamine pyrophosphokinase
S101395_RS15625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S101395_RS15630	COG1162	GTPase activity
S101395_RS15635	COG2815	serine threonine protein kinase
S101395_RS15635	COG0515	serine threonine protein kinase
S101395_RS15640	COG0631	protein serine/threonine phosphatase activity
S101395_RS15645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S101395_RS15650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S101395_RS15650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101395_RS15655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S101395_RS15660	COG0242	peptide deformylase activity
S101395_RS15665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S101395_RS15670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101395_RS15675	COG1758	RNA polymerase activity
S101395_RS15680	COG0194	GDP metabolic process
S101395_RS15685	COG2052	Domain of unknown function (DUF370)
S101395_RS15690	COG1561	YicC-like family, N-terminal region
S101395_RS15705	COG1648	precorrin-2 dehydrogenase activity
S101395_RS15710	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S101395_RS15715	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S101395_RS15720	COG0529	Catalyzes the synthesis of activated sulfate
S101395_RS15725	COG2046	Belongs to the sulfate adenylyltransferase family
S101395_RS15730	COG0306	phosphate transporter
S101395_RS15735	COG0175	sulfate reduction
S101395_RS15745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S101395_RS15750	COG0284	orotidine-5'-phosphate decarboxylase activity
S101395_RS15755	COG0167	dihydroorotate dehydrogenase activity
S101395_RS15760	COG0543	2 iron, 2 sulfur cluster binding
S101395_RS15765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101395_RS15770	COG0505	Belongs to the CarA family
S101395_RS15775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101395_RS15780	COG0540	Belongs to the ATCase OTCase family
S101395_RS15785	COG2233	PERMEase
S101395_RS15795	COG0564	pseudouridine synthase activity
S101395_RS15800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S101395_RS15805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101395_RS15810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S101395_RS15815	COG3599	regulation of cell shape
S101395_RS15820	COG2302	S4 RNA-binding domain
S101395_RS15825	COG0762	integral membrane protein
S101395_RS15830	COG1799	cell septum assembly
S101395_RS15835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S101395_RS15840	COG1496	oxidoreductase activity
S101395_RS15845	COG1873	PFAM PRC-barrel domain
S101395_RS15850	COG0500	methyltransferase
S101395_RS15855	COG0457	Tetratricopeptide repeat
S101395_RS15860	COG1119	ATPase activity
S101395_RS15865	COG1191	sigma factor activity
S101395_RS15870	COG1191	sigma factor activity
S101395_RS15880	COG1404	Belongs to the peptidase S8 family
S101395_RS15880	COG4412	M6 family metalloprotease domain protein
S101395_RS15885	COG1404	Belongs to the peptidase S8 family
S101395_RS15885	COG4412	M6 family metalloprotease domain protein
S101395_RS15890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S101395_RS15895	COG0849	cell division
S101395_RS15900	COG3856	small basic protein
S101395_RS15905	COG3879	Bacterial protein of unknown function (DUF881)
S101395_RS15910	COG3879	Bacterial protein of unknown function (DUF881)
S101395_RS15915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S101395_RS15920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S101395_RS15925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101395_RS15930	COG0772	Belongs to the SEDS family
S101395_RS15935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101395_RS15940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101395_RS15945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S101395_RS15950	COG0768	penicillin binding
S101395_RS15955	COG0768	penicillin binding
S101395_RS15960	COG4839	cell division protein FtsL
S101395_RS15965	COG0275	rRNA processing
S101395_RS15970	COG2001	Belongs to the MraZ family
S101395_RS15975	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
S101395_RS15980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S101395_RS15985	COG0454	-acetyltransferase
S101395_RS15995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
S101395_RS16000	COG1399	metal-binding, possibly nucleic acid-binding protein
S101395_RS16005	COG1323	Belongs to the UPF0348 family
S101395_RS16010	COG3480	Lon protease (S16) C-terminal proteolytic domain
S101395_RS16015	COG3314	Sporulation integral membrane protein YlbJ
S101395_RS16020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S101395_RS16025	COG0742	ribosomal rna small subunit methyltransferase
S101395_RS16030	COG4471	UPF0298 protein
S101395_RS16035	COG3679	Belongs to the UPF0342 family
S101395_RS16050	COG1834	amidinotransferase
S101395_RS16060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101395_RS16065	COG0583	DNA-binding transcription factor activity
S101395_RS16070	COG2340	Cysteine-rich secretory protein family
S101395_RS16075	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S101395_RS16085	COG3336	cytochrome c oxidase
S101395_RS16090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S101395_RS16095	COG1845	cytochrome c oxidase, subunit III
S101395_RS16100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S101395_RS16105	COG2010	Cytochrome c
S101395_RS16105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S101395_RS16110	COG0109	protoheme IX farnesyltransferase activity
S101395_RS16115	COG1612	heme a metabolic process
S101395_RS16120	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S101395_RS16125	COG0772	Belongs to the SEDS family
S101395_RS16130	COG4838	Belongs to the UPF0358 family
S101395_RS16135	COG2066	Belongs to the glutaminase family
S101395_RS16140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S101395_RS16145	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S101395_RS16155	COG4896	Protein conserved in bacteria
S101395_RS16165	COG1846	Transcriptional regulator
S101395_RS16175	COG1217	gtp-binding protein TYPA
S101395_RS16190	COG0483	inositol monophosphate 1-phosphatase activity
S101395_RS16205	COG4476	Belongs to the UPF0223 family
S101395_RS16210	COG1982	Orn Lys Arg decarboxylase major
S101395_RS16225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101395_RS16230	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101395_RS16235	COG0022	dehydrogenase e1 component
S101395_RS16240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101395_RS16245	COG0497	DNA recombination
S101395_RS16255	COG0242	peptide deformylase activity
S101395_RS16265	COG5503	Protein of unknown function (DUF1447)
S101395_RS16270	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S101395_RS16275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S101395_RS16280	COG0569	domain protein
S101395_RS16285	COG3852	Histidine kinase
S101395_RS16290	COG2002	toxin-antitoxin pair type II binding
S101395_RS16295	COG1077	Cell shape determining protein MreB Mrl
S101395_RS16305	COG2309	aminopeptidase activity
S101395_RS16315	COG0488	(ABC) transporter
S101395_RS16335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101395_RS16335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS16335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101395_RS16340	COG1105	Belongs to the carbohydrate kinase PfkB family
S101395_RS16345	COG1349	DNA-binding transcription factor activity
S101395_RS16360	COG0577	efflux transmembrane transporter activity
S101395_RS16365	COG1136	(ABC) transporter
S101395_RS16370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101395_RS16380	COG1132	(ABC) transporter
S101395_RS16385	COG1132	(ABC) transporter
S101395_RS16395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S101395_RS16400	COG0314	molybdopterin synthase activity
S101395_RS16405	COG1763	Mo-molybdopterin cofactor biosynthetic process
S101395_RS16410	COG0303	'Molybdopterin
S101395_RS16415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101395_RS16420	COG0746	molybdenum cofactor guanylyltransferase activity
S101395_RS16435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101395_RS16440	COG0450	alkyl hydroperoxide reductase
S101395_RS16450	COG1473	amidohydrolase
S101395_RS16455	COG2171	N-acyltransferase activity
S101395_RS16460	COG0716	FMN binding
S101395_RS16470	COG0716	FMN binding
S101395_RS16475	COG0583	DNA-binding transcription factor activity
S101395_RS16480	COG0517	IMP dehydrogenase activity
S101395_RS16490	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
S101395_RS16500	COG4703	Protein of unknown function (DUF1797)
S101395_RS16520	COG2200	EAL domain
S101395_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS16530	COG1408	metallophosphoesterase
S101395_RS16535	COG1376	ErfK ybiS ycfS ynhG family protein
S101395_RS16540	COG2814	Major facilitator Superfamily
S101395_RS16550	COG0835	chemotaxis
S101395_RS16550	COG0784	Response regulator, receiver
S101395_RS16560	COG1714	RDD family
S101395_RS16565	COG0436	Aminotransferase
S101395_RS16575	COG0768	penicillin binding
S101395_RS16580	COG2340	Cysteine-rich secretory protein family
S101395_RS16585	COG2084	Dehydrogenase
S101395_RS16590	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS16595	COG0840	transmembrane signaling receptor activity
S101395_RS16600	COG0456	acetyltransferase
S101395_RS16605	COG1533	DNA photolyase activity
S101395_RS16615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S101395_RS16620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS16625	COG1263	PTS System
S101395_RS16625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS16625	COG2190	(PTS) system
S101395_RS16630	COG3711	transcriptional antiterminator
S101395_RS16635	COG1609	Transcriptional regulator
S101395_RS16650	COG0006	proline dipeptidase activity
S101395_RS16655	COG2217	Heavy metal translocating P-type atpase
S101395_RS16660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101395_RS16665	COG2244	polysaccharide biosynthetic process
S101395_RS16670	COG3773	Cell wall hydrolase
S101395_RS16680	COG4873	Protein conserved in bacteria
S101395_RS16690	COG0456	acetyltransferase
S101395_RS16695	COG1522	sequence-specific DNA binding
S101395_RS16700	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S101395_RS16730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S101395_RS16735	COG0457	Tetratricopeptide repeat
S101395_RS16760	COG2378	regulation of single-species biofilm formation
S101395_RS16785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S101395_RS16790	COG0602	queuosine metabolic process
S101395_RS16795	COG0720	synthase
S101395_RS16800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S101395_RS16805	COG3949	Membrane
S101395_RS16810	COG0542	response to heat
S101395_RS16815	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S101395_RS16820	COG1360	Flagellar Motor Protein
S101395_RS16825	COG1846	Transcriptional regulator
S101395_RS16840	COG3339	Conserved Protein
S101395_RS16845	COG0346	lactoylglutathione lyase activity
S101395_RS16850	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S101395_RS16855	COG0235	Class ii aldolase
S101395_RS16855	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
S101395_RS16860	COG0235	Class ii aldolase
S101395_RS16860	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
S101395_RS16865	COG1850	ribulose-bisphosphate carboxylase activity
S101395_RS16870	COG0436	Aminotransferase
S101395_RS16875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S101395_RS16880	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S101395_RS16885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S101395_RS16890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S101395_RS16895	COG5002	protein histidine kinase activity
S101395_RS16900	COG3594	Acyltransferase
S101395_RS16915	COG0768	penicillin binding
S101395_RS16920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101395_RS16925	COG0501	Belongs to the peptidase M48B family
S101395_RS16945	COG1191	sigma factor activity
S101395_RS16950	COG0861	Integral membrane protein TerC family
S101395_RS16955	COG0586	Pfam SNARE associated Golgi protein
S101395_RS16960	COG5001	Diguanylate cyclase
S101395_RS16960	COG3300	MHYT domain
S101395_RS16965	COG5001	Diguanylate cyclase
S101395_RS16965	COG2203	Gaf domain
S101395_RS16965	COG4251	negative regulation of phosphorylation
S101395_RS16965	COG3706	GGDEF domain
S101395_RS16970	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S101395_RS16975	COG1793	dna ligase
S101395_RS16975	COG3285	dna ligase
S101395_RS16980	COG1846	Transcriptional regulator
S101395_RS16995	COG0789	Transcriptional regulator
S101395_RS17005	COG2239	Acts as a magnesium transporter
S101395_RS17015	COG1404	Belongs to the peptidase S8 family
S101395_RS17020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101395_RS17040	COG0590	tRNA wobble adenosine to inosine editing
S101395_RS17050	COG1764	response to oxidative stress
S101395_RS17055	COG1846	Transcriptional regulator
S101395_RS17060	COG1764	response to oxidative stress
S101395_RS17065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S101395_RS17070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101395_RS17075	COG0788	formyltetrahydrofolate deformylase activity
S101395_RS17080	COG2076	Multidrug Resistance protein
S101395_RS17085	COG2076	Multidrug Resistance protein
S101395_RS17090	COG2318	DinB family
S101395_RS17095	COG3866	Pectate lyase
S101395_RS17100	COG2323	membrane
S101395_RS17105	COG1607	acyl-coa hydrolase
S101395_RS17110	COG1834	amidinotransferase
S101395_RS17115	COG4608	Belongs to the ABC transporter superfamily
S101395_RS17120	COG0791	NLP P60 protein
S101395_RS17125	COG4948	Mandelate Racemase Muconate Lactonizing
S101395_RS17130	COG1619	proteins homologs of microcin C7 resistance protein MccF
S101395_RS17135	COG4166	transmembrane transport
S101395_RS17140	COG0444	Belongs to the ABC transporter superfamily
S101395_RS17145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101395_RS17150	COG0601	transmembrane transport
S101395_RS17155	COG2362	D-Aminopeptidase
S101395_RS17160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101395_RS17165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101395_RS17170	COG0346	lactoylglutathione lyase activity
S101395_RS17175	COG0531	amino acid
S101395_RS17180	COG0395	ABC-type sugar transport system, permease component
S101395_RS17185	COG4209	transmembrane transport
S101395_RS17190	COG1653	transport
S101395_RS17200	COG1874	Beta-galactosidase
S101395_RS17205	COG2755	lipolytic protein G-D-S-L family
S101395_RS17215	COG3401	FG-GAP repeat protein
S101395_RS17220	COG5578	integral membrane protein
S101395_RS17230	COG2755	lipolytic protein G-D-S-L family
S101395_RS17235	COG2207	Transcriptional regulator
S101395_RS17240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S101395_RS17245	COG0395	ABC-type sugar transport system, permease component
S101395_RS17250	COG1175	transmembrane transport
S101395_RS17255	COG1653	transport
S101395_RS17260	COG4753	response regulator
S101395_RS17260	COG2207	Transcriptional regulator
S101395_RS17265	COG2972	Histidine kinase
S101395_RS17280	COG4208	sulfate ABC transporter
S101395_RS17290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
S101395_RS17295	COG0405	Gamma-glutamyltransferase
S101395_RS17300	COG1392	Phosphate transport regulator
S101395_RS17305	COG0306	phosphate transporter
S101395_RS17320	COG2271	Major facilitator Superfamily
S101395_RS17325	COG1063	alcohol dehydrogenase
S101395_RS17330	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS17335	COG1312	Catalyzes the dehydration of D-mannonate
S101395_RS17340	COG1063	alcohol dehydrogenase
S101395_RS17345	COG1802	Transcriptional regulator
S101395_RS17385	COG1595	DNA-templated transcription, initiation
S101395_RS17415	COG1396	sequence-specific DNA binding
S101395_RS17420	COG2856	Zn peptidase
S101395_RS17425	COG4195	phage-related replication protein
S101395_RS17440	COG0697	spore germination
S101395_RS17445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101395_RS17460	COG1309	transcriptional regulator
S101395_RS17465	COG2814	Major facilitator Superfamily
S101395_RS17475	COG3584	3D domain protein
S101395_RS17475	COG1388	LysM domain
S101395_RS17485	COG0346	lactoylglutathione lyase activity
S101395_RS17495	COG0583	DNA-binding transcription factor activity
S101395_RS17500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101395_RS17505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101395_RS17510	COG0583	DNA-binding transcription factor activity
S101395_RS17520	COG0110	maltose O-acetyltransferase activity
S101395_RS17540	COG1388	LysM domain
S101395_RS17545	COG2267	carboxylic ester hydrolase activity
S101395_RS17550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S101395_RS17555	COG0129	dihydroxy-acid dehydratase activity
S101395_RS17570	COG1902	pentaerythritol trinitrate reductase activity
S101395_RS17575	COG1522	sequence-specific DNA binding
S101395_RS17595	COG1073	alpha beta
S101395_RS17605	COG0457	Tetratricopeptide repeat
S101395_RS17635	COG5444	nuclease activity
S101395_RS17645	COG5444	nuclease activity
S101395_RS17650	COG4282	regulation of fungal-type cell wall biogenesis
S101395_RS17665	COG5505	Protein of unknown function (DUF819)
S101395_RS17670	COG0626	cystathionine gamma-synthase activity
S101395_RS17675	COG0626	cystathionine gamma-synthase activity
S101395_RS17680	COG2382	esterase
S101395_RS17685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S101395_RS17690	COG2153	protein acetylation
S101395_RS17695	COG2246	polysaccharide biosynthetic process
S101395_RS17700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101395_RS17705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S101395_RS17710	COG0586	Pfam SNARE associated Golgi protein
S101395_RS17720	COG0210	DNA helicase
S101395_RS17775	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S101395_RS17780	COG0351	phosphomethylpyrimidine kinase
S101395_RS17785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101395_RS17790	COG2022	thiamine diphosphate biosynthetic process
S101395_RS17795	COG2104	thiamine diphosphate biosynthetic process
S101395_RS17805	COG0352	thiamine-phosphate diphosphorylase activity
S101395_RS17810	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S101395_RS17815	COG0475	glutathione-regulated potassium exporter activity
S101395_RS17815	COG0569	domain protein
S101395_RS17825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S101395_RS17830	COG0564	pseudouridine synthase activity
S101395_RS17835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S101395_RS17840	COG2357	RelA SpoT domain protein
S101395_RS17850	COG4116	CYTH
S101395_RS17855	COG0741	lytic transglycosylase activity
S101395_RS17860	COG2346	COG2346, Truncated hemoglobins
S101395_RS17865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S101395_RS17880	COG1164	Oligoendopeptidase f
S101395_RS17885	COG4469	Competence protein
S101395_RS17890	COG4862	establishment of competence for transformation
S101395_RS17895	COG0861	Integral membrane protein TerC family
S101395_RS17900	COG1393	Belongs to the ArsC family
S101395_RS17905	COG0456	acetyltransferase
S101395_RS17910	COG4608	Belongs to the ABC transporter superfamily
S101395_RS17915	COG0444	Belongs to the ABC transporter superfamily
S101395_RS17920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101395_RS17925	COG0601	transmembrane transport
S101395_RS17930	COG4166	transmembrane transport
S101395_RS17935	COG0180	Tryptophanyl-tRNA synthetase
S101395_RS17945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101395_RS17950	COG0601	transmembrane transport
S101395_RS17960	COG4608	Belongs to the ABC transporter superfamily
S101395_RS17965	COG0444	Belongs to the ABC transporter superfamily
S101395_RS17970	COG5504	Zn-dependent protease
S101395_RS17975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S101395_RS17980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101395_RS17995	COG1744	ABC transporter substrate-binding protein PnrA-like
S101395_RS18005	COG2267	carboxylic ester hydrolase activity
S101395_RS18020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S101395_RS18025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101395_RS18030	COG0505	Belongs to the CarA family
S101395_RS18035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S101395_RS18040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
S101395_RS18045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S101395_RS18050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S101395_RS18060	COG2151	metal-sulfur cluster biosynthetic enzyme
S101395_RS18065	COG1073	alpha beta
S101395_RS18070	COG0561	phosphatase activity
S101395_RS18080	COG0516	GMP reductase activity
S101395_RS18090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101395_RS18095	COG1307	EDD domain protein, DegV family
S101395_RS18110	COG2996	Protein conserved in bacteria
S101395_RS18115	COG1666	GTP binding
S101395_RS18120	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S101395_RS18120	COG0646	methionine synthase
S101395_RS18125	COG1410	methionine synthase
S101395_RS18125	COG0646	methionine synthase
S101395_RS18150	COG0076	glutamate decarboxylase activity
S101395_RS18160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101395_RS18165	COG1279	arginine transmembrane transporter activity
S101395_RS18170	COG0673	inositol 2-dehydrogenase activity
S101395_RS18175	COG1609	Transcriptional regulator
S101395_RS18185	COG2207	Transcriptional regulator
S101395_RS18185	COG1917	Cupin 2, conserved barrel domain protein
S101395_RS18190	COG0534	Mate efflux family protein
S101395_RS18195	COG0367	asparagine synthase
S101395_RS18215	COG0179	Fumarylacetoacetate (FAA) hydrolase
S101395_RS18225	COG5337	Spore coat protein CotH
S101395_RS18270	COG0419	ATPase involved in DNA repair
S101395_RS18275	COG0420	3'-5' exonuclease activity
S101395_RS18280	COG1074	ATP-dependent DNA helicase activity
S101395_RS18285	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S101395_RS18290	COG4149	molybdate abc transporter
S101395_RS18295	COG0725	ABC transporter, periplasmic molybdate-binding protein
S101395_RS18300	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S101395_RS18305	COG0745	RESPONSE REGULATOR receiver
S101395_RS18310	COG5002	protein histidine kinase activity
S101395_RS18315	COG2720	vancomycin resistance protein
S101395_RS18325	COG0477	Major facilitator Superfamily
S101395_RS18325	COG2814	Major facilitator Superfamily
S101395_RS18330	COG0318	PFAM AMP-dependent synthetase and ligase
S101395_RS18335	COG3546	catalase activity
S101395_RS18350	COG3180	Ammonia monooxygenase
S101395_RS18355	COG0549	Belongs to the carbamate kinase family
S101395_RS18365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S101395_RS18375	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S101395_RS18380	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S101395_RS18385	COG3257	ureidoglycine aminohydrolase activity
S101395_RS18390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101395_RS18400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101395_RS18410	COG2508	Transcriptional regulator
S101395_RS18425	COG3421	Type III restriction
S101395_RS18430	COG2189	Belongs to the N(4) N(6)-methyltransferase family
S101395_RS18445	COG0681	Belongs to the peptidase S26 family
S101395_RS18450	COG0398	Pfam SNARE associated Golgi protein
S101395_RS18460	COG4903	ComK protein
S101395_RS18470	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS18475	COG0723	plastoquinol--plastocyanin reductase activity
S101395_RS18475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101395_RS18480	COG0840	transmembrane signaling receptor activity
S101395_RS18485	COG0406	alpha-ribazole phosphatase activity
S101395_RS18490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS18495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS18500	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S101395_RS18510	COG0501	Belongs to the peptidase M48B family
S101395_RS18525	COG1396	sequence-specific DNA binding
S101395_RS18535	COG0318	PFAM AMP-dependent synthetase and ligase
S101395_RS18540	COG0095	Lipoate-protein ligase
S101395_RS18545	COG1234	tRNA 3'-trailer cleavage
S101395_RS18555	COG1301	dicarboxylic acid transport
S101395_RS18560	COG1363	Peptidase, m42
S101395_RS18565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101395_RS18570	COG1511	domain protein
S101395_RS18575	COG1309	transcriptional regulator
S101395_RS18580	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
S101395_RS18585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S101395_RS18590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S101395_RS18595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101395_RS18600	COG2329	Antibiotic biosynthesis monooxygenase
S101395_RS18605	COG3069	C4-dicarboxylate transmembrane transporter activity
S101395_RS18610	COG1473	amidohydrolase
S101395_RS18620	COG4473	ABC transporter
S101395_RS18625	COG1131	(ABC) transporter
S101395_RS18635	COG0537	adenosine 5'-monophosphoramidase activity
S101395_RS18640	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S101395_RS18655	COG4980	gas vesicle protein
S101395_RS18660	COG1846	Transcriptional regulator
S101395_RS18690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101395_RS18700	COG3481	metal-dependent phosphohydrolase, HD sub domain
S101395_RS18705	COG4717	serine-type aminopeptidase activity
S101395_RS18710	COG0420	3'-5' exonuclease activity
S101395_RS18715	COG1668	transmembrane transport
S101395_RS18720	COG4152	abc transporter atp-binding protein
S101395_RS18740	COG1024	Enoyl-CoA hydratase
S101395_RS18750	COG0490	domain, Protein
S101395_RS18755	COG0475	glutathione-regulated potassium exporter activity
S101395_RS18765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101395_RS18770	COG0561	phosphatase activity
S101395_RS18780	COG3679	Belongs to the UPF0342 family
S101395_RS18785	COG4399	Belongs to the UPF0754 family
S101395_RS18790	COG0189	ligase activity
S101395_RS18795	COG0189	ligase activity
S101395_RS18805	COG2508	Transcriptional regulator
S101395_RS18810	COG3842	ATPase activity
S101395_RS18825	COG0702	epimerase
S101395_RS18830	COG1132	(ABC) transporter
S101395_RS18835	COG1132	(ABC) transporter
S101395_RS18845	COG0589	response to stress
S101395_RS18865	COG2017	converts alpha-aldose to the beta-anomer
S101395_RS18870	COG1757	Na H antiporter
S101395_RS18880	COG0726	polysaccharide deacetylase
S101395_RS18890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S101395_RS18895	COG0668	transmembrane transport
S101395_RS18905	COG0584	glycerophosphoryl diester phosphodiesterase
S101395_RS18910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101395_RS18915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101395_RS18935	COG1253	flavin adenine dinucleotide binding
S101395_RS18940	COG0789	Transcriptional regulator
S101395_RS18945	COG1253	flavin adenine dinucleotide binding
S101395_RS18950	COG1309	transcriptional regulator
S101395_RS18960	COG0204	Acyl-transferase
S101395_RS18965	COG1595	DNA-templated transcription, initiation
S101395_RS18980	COG0456	acetyltransferase
S101395_RS18985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101395_RS18990	COG2207	Transcriptional regulator
S101395_RS18990	COG3708	Transcriptional regulator
S101395_RS19000	COG0733	neurotransmitter:sodium symporter activity
S101395_RS19005	COG0531	amino acid
S101395_RS19020	COG0372	Belongs to the citrate synthase family
S101395_RS19025	COG0583	DNA-binding transcription factor activity
S101395_RS19030	COG0791	NLP P60 protein
S101395_RS19030	COG1388	LysM domain
S101395_RS19040	COG1785	Belongs to the alkaline phosphatase family
S101395_RS19045	COG2719	SpoVR family
S101395_RS19050	COG1017	nitric oxide dioxygenase activity
S101395_RS19050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S101395_RS19055	COG1959	2 iron, 2 sulfur cluster binding
S101395_RS19070	COG0431	NADPH-dependent FMN reductase
S101395_RS19075	COG2197	response regulator
S101395_RS19080	COG4585	Histidine kinase
S101395_RS19080	COG2203	Gaf domain
S101395_RS19100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101395_RS19105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S101395_RS19115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S101395_RS19120	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
S101395_RS19125	COG0604	alcohol dehydrogenase
S101395_RS19130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101395_RS19135	COG0679	Auxin Efflux Carrier
S101395_RS19150	COG3153	acetyltransferase
S101395_RS19150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S101395_RS19155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101395_RS19160	COG0517	IMP dehydrogenase activity
S101395_RS19170	COG0564	pseudouridine synthase activity
S101395_RS19175	COG1174	glycine betaine transport
S101395_RS19180	COG1732	Glycine betaine
S101395_RS19185	COG1174	glycine betaine transport
S101395_RS19190	COG1125	glycine betaine transport
S101395_RS19190	COG0517	IMP dehydrogenase activity
S101395_RS19195	COG3764	Sortase (surface protein transpeptidase)
S101395_RS19200	COG0737	Belongs to the 5'-nucleotidase family
S101395_RS19200	COG4085	toxin activity
S101395_RS19200	COG1525	nuclease
S101395_RS19205	COG5002	protein histidine kinase activity
S101395_RS19210	COG5577	PFAM Coat F domain
S101395_RS19235	COG1823	symporter activity
S101395_RS19240	COG1464	Belongs to the NlpA lipoprotein family
S101395_RS19245	COG2011	ABC-type metal ion transport system permease component
S101395_RS19250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S101395_RS19255	COG1278	Cold shock
S101395_RS19260	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101395_RS19265	COG1131	(ABC) transporter
S101395_RS19270	COG1131	(ABC) transporter
S101395_RS19275	COG1725	Transcriptional regulator
S101395_RS19290	COG0655	NAD(P)H dehydrogenase (quinone) activity
S101395_RS19300	COG1566	PFAM secretion protein HlyD family protein
S101395_RS19305	COG2718	Belongs to the UPF0229 family
S101395_RS19320	COG1664	Polymer-forming cytoskeletal
S101395_RS19325	COG0789	Transcriptional regulator
S101395_RS19330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S101395_RS19340	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S101395_RS19345	COG3382	B3 4 domain protein
S101395_RS19355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S101395_RS19360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101395_RS19365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101395_RS19370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101395_RS19375	COG1116	anion transmembrane transporter activity
S101395_RS19380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S101395_RS19385	COG4326	sporulation control protein
S101395_RS19390	COG0710	3-dehydroquinate dehydratase activity
S101395_RS19405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S101395_RS19445	COG1388	LysM domain
S101395_RS19445	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101395_RS19445	COG3409	Peptidoglycan-binding domain 1 protein
S101395_RS19550	COG0582	viral genome integration into host DNA
S101395_RS19650	COG3584	3D domain protein
S101395_RS19655	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
S101395_RS19665	COG0756	dUTP diphosphatase activity
S101395_RS19670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101395_RS19675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101395_RS19680	COG1780	Probably involved in ribonucleotide reductase function
S101395_RS19720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101395_RS19720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101395_RS19755	COG1396	sequence-specific DNA binding
S101395_RS19855	COG4974	Belongs to the 'phage' integrase family
S101395_RS19920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101395_RS19930	COG1408	metallophosphoesterase
S101395_RS19935	COG1968	undecaprenyl-diphosphatase activity
S101395_RS19940	COG0628	permease
S101395_RS19945	COG0673	inositol 2-dehydrogenase activity
S101395_RS19950	COG0840	transmembrane signaling receptor activity
S101395_RS19955	COG0840	transmembrane signaling receptor activity
S101395_RS19975	COG0432	Pfam Uncharacterised protein family UPF0047
S101395_RS19980	COG5297	Belongs to the glycosyl hydrolase family 6
S101395_RS19985	COG1253	flavin adenine dinucleotide binding
S101395_RS19990	COG2738	Putative neutral zinc metallopeptidase
S101395_RS20005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S101395_RS20015	COG2323	membrane
S101395_RS20020	COG0166	Belongs to the GPI family
S101395_RS20025	COG1979	alcohol dehydrogenase
S101395_RS20030	COG2155	Conserved Protein
S101395_RS20035	COG1098	S1 RNA binding domain
S101395_RS20040	COG0436	Aminotransferase
S101395_RS20045	COG1522	sequence-specific DNA binding
S101395_RS20050	COG2267	carboxylic ester hydrolase activity
S101395_RS20065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S101395_RS20080	COG5018	Exonuclease
S101395_RS20085	COG2814	Major facilitator Superfamily
S101395_RS20090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101395_RS20095	COG3011	Protein conserved in bacteria
S101395_RS20105	COG3290	protein histidine kinase activity
S101395_RS20110	COG4565	transcriptional regulatory protein
S101395_RS20115	COG1744	ABC transporter substrate-binding protein PnrA-like
S101395_RS20120	COG3845	ABC transporter
S101395_RS20125	COG4603	Belongs to the binding-protein-dependent transport system permease family
S101395_RS20135	COG1183	phosphatidylcholine synthase activity
S101395_RS20140	COG0586	Pfam SNARE associated Golgi protein
S101395_RS20145	COG0688	phosphatidylethanolamine metabolic process
S101395_RS20150	COG3493	citrate carrier protein
S101395_RS20165	COG2111	Na H antiporter
S101395_RS20170	COG1006	Multisubunit Na H antiporter MnhC subunit
S101395_RS20175	COG0651	ATP synthesis coupled electron transport
S101395_RS20180	COG1863	multisubunit Na H antiporter MnhE subunit
S101395_RS20185	COG2212	antiporter activity
S101395_RS20190	COG1320	monovalent cation:proton antiporter activity
S101395_RS20195	COG2050	protein possibly involved in aromatic compounds catabolism
S101395_RS20200	COG2197	response regulator
S101395_RS20215	COG0142	geranyltranstransferase activity
S101395_RS20235	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S101395_RS20240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S101395_RS20245	COG1335	isochorismatase
S101395_RS20250	COG5506	Protein of unknown function (DUF1694)
S101395_RS20265	COG0628	permease
S101395_RS20270	COG1959	2 iron, 2 sulfur cluster binding
S101395_RS20275	COG0657	acetylesterase activity
S101395_RS20285	COG1418	mRNA catabolic process
S101395_RS20295	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS20315	COG1674	ftsk spoiiie
S101395_RS20315	COG0433	COG0433 Predicted ATPase
S101395_RS20320	COG4499	WXG100 protein secretion system (Wss), protein YukC
S101395_RS20325	COG5417	Belongs to the EsaB family
S101395_RS20330	COG4842	Belongs to the WXG100 family
S101395_RS20335	COG1115	amino acid carrier protein
S101395_RS20340	COG2508	Transcriptional regulator
S101395_RS20340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S101395_RS20345	COG0686	Belongs to the AlaDH PNT family
S101395_RS20350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S101395_RS20355	COG1268	BioY protein
S101395_RS20365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S101395_RS20370	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S101395_RS20375	COG3584	3D domain protein
S101395_RS20390	COG0492	ferredoxin-NADP+ reductase activity
S101395_RS20405	COG0316	Belongs to the HesB IscA family
S101395_RS20410	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S101395_RS20415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101395_RS20420	COG4844	belongs to the
S101395_RS20425	COG1252	NADH dehydrogenase
S101395_RS20440	COG0457	Tetratricopeptide repeat
S101395_RS20445	COG3479	Phenolic acid decarboxylase
S101395_RS20455	COG4837	Protein of unknown function (DUF1462)
S101395_RS20460	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S101395_RS20465	COG1506	peptidase
S101395_RS20465	COG4946	Tricorn protease homolog
S101395_RS20465	COG0823	Involved in the tonB-independent uptake of proteins
S101395_RS20470	COG0083	homoserine kinase activity
S101395_RS20475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S101395_RS20480	COG0460	homoserine dehydrogenase
S101395_RS20485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101395_RS20490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101395_RS20495	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S101395_RS20500	COG0647	UMP catabolic process
S101395_RS20505	COG2445	Protein of unknown function DUF86
S101395_RS20510	COG4470	Protein conserved in bacteria
S101395_RS20525	COG0739	heme binding
S101395_RS20530	COG0733	neurotransmitter:sodium symporter activity
S101395_RS20540	COG3377	Domain of unknown function (DUF1805)
S101395_RS20545	COG0737	Belongs to the 5'-nucleotidase family
S101395_RS20550	COG0730	response to heat
S101395_RS20565	COG3226	Transcriptional regulator
S101395_RS20570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101395_RS20580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S101395_RS20585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101395_RS20590	COG2508	Transcriptional regulator
S101395_RS20595	COG2814	Major facilitator Superfamily
S101395_RS20600	COG1288	antiporter activity
S101395_RS20605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S101395_RS20615	COG2356	endonuclease I
S101395_RS20620	COG3842	ATPase activity
S101395_RS20625	COG2188	Transcriptional regulator
S101395_RS20630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101395_RS20635	COG0395	ABC-type sugar transport system, permease component
S101395_RS20640	COG1175	transmembrane transport
S101395_RS20650	COG2222	sugar isomerase
S101395_RS20655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101395_RS20675	COG0482	sulfurtransferase activity
S101395_RS20715	COG0719	Fe-S assembly protein
S101395_RS20720	COG0822	iron-sulfur transferase activity
S101395_RS20725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S101395_RS20730	COG0719	Fe-S assembly protein
S101395_RS20735	COG0396	ATPase activity
S101395_RS20745	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S101395_RS20750	COG1464	Belongs to the NlpA lipoprotein family
S101395_RS20755	COG2011	ABC-type metal ion transport system permease component
S101395_RS20760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S101395_RS20770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101395_RS20775	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S101395_RS20785	COG0509	glycine decarboxylation via glycine cleavage system
S101395_RS20790	COG1393	Belongs to the ArsC family
S101395_RS20795	COG1960	acyl-CoA dehydrogenase activity
S101395_RS20800	COG0183	Belongs to the thiolase family
S101395_RS20805	COG1024	Enoyl-CoA hydratase
S101395_RS20805	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101395_RS20820	COG5577	PFAM Coat F domain
S101395_RS20835	COG1120	ATPase activity
S101395_RS20840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS20845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS20850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101395_RS20865	COG1686	Belongs to the peptidase S11 family
S101395_RS20870	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS20875	COG0783	Belongs to the Dps family
S101395_RS20880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101395_RS20885	COG0745	RESPONSE REGULATOR receiver
S101395_RS20890	COG2770	Histidine kinase
S101395_RS20890	COG2205	protein histidine kinase activity
S101395_RS20900	COG1309	transcriptional regulator
S101395_RS20905	COG0114	fumarate hydratase activity
S101395_RS20915	COG0697	spore germination
S101395_RS20920	COG0814	amino acid
S101395_RS20935	COG2197	response regulator
S101395_RS20940	COG4585	Histidine kinase
S101395_RS20945	COG4758	membrane
S101395_RS20950	COG3595	metallopeptidase activity
S101395_RS20955	COG1842	Phage shock protein A
S101395_RS20960	COG4758	membrane
S101395_RS20965	COG4677	pectinesterase activity
S101395_RS20970	COG2096	Adenosyltransferase
S101395_RS20975	COG1120	ATPase activity
S101395_RS20980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS20985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101395_RS20990	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS20995	COG2258	MOSC domain
S101395_RS21010	COG2721	sulfolactate sulfo-lyase activity
S101395_RS21015	COG0246	Mannitol dehydrogenase
S101395_RS21020	COG1609	Transcriptional regulator
S101395_RS21025	COG2211	Major facilitator Superfamily
S101395_RS21030	COG1904	glucuronate isomerase
S101395_RS21035	COG2205	protein histidine kinase activity
S101395_RS21040	COG0745	RESPONSE REGULATOR receiver
S101395_RS21045	COG1120	ATPase activity
S101395_RS21050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS21055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS21060	COG0531	amino acid
S101395_RS21070	COG1988	membrane-bound metal-dependent
S101395_RS21075	COG1368	sulfuric ester hydrolase activity
S101395_RS21080	COG2814	Major facilitator Superfamily
S101395_RS21085	COG0656	L-ascorbic acid biosynthetic process
S101395_RS21090	COG1940	carbohydrate kinase activity
S101395_RS21110	COG3973	AAA domain
S101395_RS21115	COG2860	membrane
S101395_RS21120	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S101395_RS21120	COG0456	acetyltransferase
S101395_RS21150	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S101395_RS21155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S101395_RS21160	COG2217	Heavy metal translocating P-type atpase
S101395_RS21170	COG1175	transmembrane transport
S101395_RS21175	COG0395	ABC-type sugar transport system, permease component
S101395_RS21180	COG1501	Belongs to the glycosyl hydrolase 31 family
S101395_RS21190	COG1121	(ABC) transporter
S101395_RS21195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101395_RS21215	COG1105	Belongs to the carbohydrate kinase PfkB family
S101395_RS21220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101395_RS21220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS21220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101395_RS21225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101395_RS21225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101395_RS21225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS21240	COG2217	Heavy metal translocating P-type atpase
S101395_RS21245	COG2608	mercury ion transmembrane transporter activity
S101395_RS21250	COG1937	Protein conserved in bacteria
S101395_RS21255	COG0693	protein deglycase activity
S101395_RS21260	COG1349	DNA-binding transcription factor activity
S101395_RS21265	COG1070	Carbohydrate kinase
S101395_RS21275	COG2814	Major facilitator Superfamily
S101395_RS21280	COG3340	Belongs to the peptidase S51 family
S101395_RS21285	COG2814	Major facilitator Superfamily
S101395_RS21290	COG1846	Transcriptional regulator
S101395_RS21295	COG1819	glycosyl
S101395_RS21300	COG0673	inositol 2-dehydrogenase activity
S101395_RS21305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S101395_RS21310	COG1054	Belongs to the UPF0176 family
S101395_RS21320	COG1191	sigma factor activity
S101395_RS21330	COG2140	Oxalate decarboxylase
S101395_RS21375	COG5444	nuclease activity
S101395_RS21430	COG5434	Belongs to the glycosyl hydrolase 28 family
S101395_RS21435	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101395_RS21445	COG5280	Phage tail tape measure protein TP901
S101395_RS21445	COG3953	SLT domain
S101395_RS21505	COG4626	Terminase
S101395_RS21505	COG1802	Transcriptional regulator
S101395_RS21610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S101395_RS21615	COG4974	Belongs to the 'phage' integrase family
S101395_RS21620	COG0459	protein refolding
S101395_RS21625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
S101395_RS21630	COG1266	CAAX protease self-immunity
S101395_RS21640	COG0805	protein transport
S101395_RS21645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101395_RS21650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S101395_RS21655	COG0315	cyclic pyranopterin monophosphate synthase activity
S101395_RS21660	COG0488	(ABC) transporter
S101395_RS21665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S101395_RS21670	COG0456	acetyltransferase
S101395_RS21675	COG1214	PFAM Peptidase M22, glycoprotease
S101395_RS21680	COG0802	atpase or kinase
S101395_RS21685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S101395_RS21725	COG2814	Major facilitator Superfamily
S101395_RS21730	COG3764	Sortase (surface protein transpeptidase)
S101395_RS21740	COG0745	RESPONSE REGULATOR receiver
S101395_RS21740	COG2972	Histidine kinase
S101395_RS21745	COG1979	alcohol dehydrogenase
S101395_RS21750	COG2814	Major facilitator Superfamily
S101395_RS21755	COG0494	nUDIX hydrolase
S101395_RS21760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S101395_RS21760	COG2755	lipolytic protein G-D-S-L family
S101395_RS21770	COG1595	DNA-templated transcription, initiation
S101395_RS21775	COG5566	PFAM Mor transcription activator
S101395_RS21780	COG0596	Alpha beta hydrolase
S101395_RS21790	COG1309	transcriptional regulator
S101395_RS21810	COG1113	amino acid transport
S101395_RS21815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101395_RS21820	COG0778	Nitroreductase
S101395_RS21825	COG1846	Transcriptional regulator
S101395_RS21830	COG0583	DNA-binding transcription factor activity
S101395_RS21845	COG1114	Component of the transport system for branched-chain amino acids
S101395_RS21850	COG1309	transcriptional regulator
S101395_RS21855	COG2814	Major facilitator Superfamily
S101395_RS21860	COG2249	NAD(P)H dehydrogenase (quinone) activity
S101395_RS21865	COG1733	regulation of RNA biosynthetic process
S101395_RS21875	COG0789	Transcriptional regulator
S101395_RS21875	COG4978	Transcriptional regulator
S101395_RS21880	COG2814	Major facilitator Superfamily
S101395_RS21895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101395_RS21910	COG1733	regulation of RNA biosynthetic process
S101395_RS21920	COG0457	Tetratricopeptide repeat
S101395_RS21930	COG4124	Belongs to the glycosyl hydrolase 26 family
S101395_RS21935	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
S101395_RS21940	COG0640	Transcriptional regulator
S101395_RS21945	COG0477	Major facilitator Superfamily
S101395_RS21950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101395_RS21955	COG1278	Cold shock
S101395_RS21965	COG3239	Fatty acid desaturase
S101395_RS21980	COG0726	polysaccharide deacetylase
S101395_RS21995	COG0457	Tetratricopeptide repeat
S101395_RS22040	COG3091	SprT-like family
S101395_RS22050	COG2409	Drug exporters of the RND superfamily
S101395_RS22050	COG1033	growth of symbiont in host cell
S101395_RS22055	COG1309	transcriptional regulator
S101395_RS22060	COG2183	response to ionizing radiation
S101395_RS22065	COG2208	phosphoserine phosphatase activity
S101395_RS22070	COG1191	sigma factor activity
S101395_RS22085	COG2208	phosphoserine phosphatase activity
S101395_RS22090	COG2172	sigma factor antagonist activity
S101395_RS22095	COG1366	Belongs to the anti-sigma-factor antagonist family
S101395_RS22100	COG1366	Belongs to the anti-sigma-factor antagonist family
S101395_RS22105	COG2337	Toxic component of a toxin-antitoxin (TA) module
S101395_RS22110	COG0864	Transcriptional regulator
S101395_RS22115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101395_RS22120	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S101395_RS22125	COG0705	Rhomboid family
S101395_RS22130	COG3428	Bacterial PH domain
S101395_RS22135	COG3402	PFAM membrane-flanked domain
S101395_RS22140	COG0513	Belongs to the DEAD box helicase family
S101395_RS22150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S101395_RS22155	COG1181	Belongs to the D-alanine--D-alanine ligase family
S101395_RS22160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101395_RS22175	COG1960	acyl-CoA dehydrogenase activity
S101395_RS22185	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101395_RS22190	COG1131	(ABC) transporter
S101395_RS22195	COG1301	dicarboxylic acid transport
S101395_RS22215	COG2217	Heavy metal translocating P-type atpase
S101395_RS22225	COG1819	glycosyl
S101395_RS22230	COG1027	Aspartate ammonia-lyase
S101395_RS22235	COG2261	transglycosylase associated protein
S101395_RS22240	COG1914	H( )-stimulated, divalent metal cation uptake system
S101395_RS22245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101395_RS22255	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS22265	COG0028	Belongs to the TPP enzyme family
S101395_RS22270	COG0531	amino acid
S101395_RS22285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101395_RS22285	COG0551	DNA topoisomerase type I activity
S101395_RS22290	COG1522	sequence-specific DNA binding
S101395_RS22300	COG2814	Major facilitator Superfamily
S101395_RS22320	COG3871	stress protein (general stress protein 26)
S101395_RS22325	COG1917	Cupin 2, conserved barrel domain protein
S101395_RS22330	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS22335	COG3711	transcriptional antiterminator
S101395_RS22340	COG0246	Mannitol dehydrogenase
S101395_RS22345	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101395_RS22350	COG2213	PTS system mannitol-specific
S101395_RS22355	COG2755	lipolytic protein G-D-S-L family
S101395_RS22360	COG1414	Transcriptional regulator
S101395_RS22365	COG1984	allophanate hydrolase subunit 2
S101395_RS22370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S101395_RS22375	COG4336	lyase activity
S101395_RS22380	COG1914	H( )-stimulated, divalent metal cation uptake system
S101395_RS22385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S101395_RS22390	COG0561	phosphatase activity
S101395_RS22430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101395_RS22460	COG1587	Uroporphyrinogen-III synthase
S101395_RS22460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S101395_RS22465	COG2146	nitrite reductase [NAD(P)H] activity
S101395_RS22475	COG0243	molybdopterin cofactor binding
S101395_RS22490	COG1349	DNA-binding transcription factor activity
S101395_RS22495	COG2372	response to copper ion
S101395_RS22495	COG1276	copper resistance
S101395_RS22500	COG4549	nuclear export factor GLE1
S101395_RS22505	COG0697	spore germination
S101395_RS22510	COG1012	belongs to the aldehyde dehydrogenase family
S101395_RS22530	COG0640	Transcriptional regulator
S101395_RS22535	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S101395_RS22540	COG0778	Nitroreductase
S101395_RS22565	COG4604	ABC transporter, ATP-binding protein
S101395_RS22575	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS22585	COG0840	transmembrane signaling receptor activity
S101395_RS22585	COG5278	phosphoserine phosphatase activity
S101395_RS22595	COG0745	RESPONSE REGULATOR receiver
S101395_RS22600	COG0577	efflux transmembrane transporter activity
S101395_RS22615	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S101395_RS22625	COG0697	spore germination
S101395_RS22635	COG5434	Belongs to the glycosyl hydrolase 28 family
S101395_RS22640	COG3104	oligopeptide transport
S101395_RS22645	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
S101395_RS22650	COG1874	Beta-galactosidase
S101395_RS22660	COG2271	Major facilitator Superfamily
S101395_RS22665	COG4214	carbohydrate transport
S101395_RS22680	COG2207	Transcriptional regulator
S101395_RS22680	COG4753	response regulator
S101395_RS22685	COG2972	Histidine kinase
S101395_RS22735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S101395_RS22740	COG0163	prenyltransferase activity
S101395_RS22750	COG2808	Putative FMN-binding domain
S101395_RS22755	COG0456	acetyltransferase
S101395_RS22760	COG1846	Transcriptional regulator
S101395_RS22770	COG0010	Belongs to the arginase family
S101395_RS22775	COG0833	amino acid
S101395_RS22780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S101395_RS22785	COG3829	transcription factor binding
S101395_RS22790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101395_RS22795	COG0765	amino acid transport
S101395_RS22800	COG1126	abc transporter atp-binding protein
S101395_RS22825	COG2364	Membrane
S101395_RS22865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101395_RS22870	COG0697	spore germination
S101395_RS22875	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S101395_RS22880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101395_RS22885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101395_RS22890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101395_RS22895	COG2814	Major facilitator Superfamily
S101395_RS22910	COG1176	ABC-type spermidine putrescine transport system, permease component I
S101395_RS22935	COG5444	nuclease activity
S101395_RS22950	COG2723	6-phospho-beta-galactosidase activity
S101395_RS22960	COG1120	ATPase activity
S101395_RS22965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS22970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS22975	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S101395_RS22985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101395_RS22990	COG0765	amino acid transport
S101395_RS23015	COG3458	cephalosporin-C deacetylase activity
S101395_RS23020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S101395_RS23025	COG0701	Predicted permease
S101395_RS23030	COG3689	TIGRFAM TIGR03943 family protein
S101395_RS23035	COG2508	Transcriptional regulator
S101395_RS23045	COG1012	belongs to the aldehyde dehydrogenase family
S101395_RS23050	COG0506	proline dehydrogenase activity
S101395_RS23055	COG3541	Predicted nucleotidyltransferase
S101395_RS23065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S101395_RS23070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S101395_RS23075	COG1113	amino acid transport
S101395_RS23080	COG1280	lysine exporter protein (LysE YggA)
S101395_RS23085	COG1620	l-lactate permease
S101395_RS23090	COG0039	L-malate dehydrogenase activity
S101395_RS23100	COG1288	antiporter activity
S101395_RS23105	COG1473	amidohydrolase
S101395_RS23110	COG2113	Glycine betaine
S101395_RS23115	COG4176	ABC-type proline glycine betaine transport system permease component
S101395_RS23120	COG4175	Glycine betaine
S101395_RS23120	COG0517	IMP dehydrogenase activity
S101395_RS23125	COG3853	Toxic anion resistance protein (TelA)
S101395_RS23160	COG0861	Integral membrane protein TerC family
S101395_RS23165	COG2310	stress, protein
S101395_RS23170	COG2310	stress, protein
S101395_RS23175	COG2310	stress, protein
S101395_RS23190	COG1309	transcriptional regulator
S101395_RS23195	COG1131	(ABC) transporter
S101395_RS23205	COG3883	PFAM NLP P60 protein
S101395_RS23205	COG0791	NLP P60 protein
S101395_RS23210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101395_RS23215	COG3773	Cell wall hydrolase
S101395_RS23225	COG1595	DNA-templated transcription, initiation
S101395_RS23235	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS23240	COG3591	Belongs to the peptidase S1B family
S101395_RS23245	COG0277	FAD linked oxidase domain protein
S101395_RS23250	COG0247	lactate metabolic process
S101395_RS23260	COG2261	transglycosylase associated protein
S101395_RS23265	COG1164	Oligoendopeptidase f
S101395_RS23275	COG0456	acetyltransferase
S101395_RS23280	COG0252	asparaginase activity
S101395_RS23290	COG1288	antiporter activity
S101395_RS23305	COG1028	Short-chain dehydrogenase reductase Sdr
S101395_RS23310	COG1942	4-Oxalocrotonate Tautomerase
S101395_RS23315	COG0583	DNA-binding transcription factor activity
S101395_RS23325	COG1405	negative regulation of cell septum assembly
S101395_RS23325	COG3012	SEC-C Motif Domain Protein
S101395_RS23330	COG1714	RDD family
S101395_RS23335	COG0697	spore germination
S101395_RS23350	COG0789	Transcriptional regulator
S101395_RS23375	COG0318	PFAM AMP-dependent synthetase and ligase
S101395_RS23380	COG1846	Transcriptional regulator
S101395_RS23385	COG3173	Aminoglycoside phosphotransferase
S101395_RS23415	COG1131	(ABC) transporter
S101395_RS23420	COG2205	protein histidine kinase activity
S101395_RS23425	COG0745	RESPONSE REGULATOR receiver
S101395_RS23445	COG2721	sulfolactate sulfo-lyase activity
S101395_RS23450	COG2186	Transcriptional regulator
S101395_RS23455	COG4948	Mandelate Racemase Muconate Lactonizing
S101395_RS23460	COG2271	Major facilitator Superfamily
S101395_RS23465	COG1012	belongs to the aldehyde dehydrogenase family
S101395_RS23470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S101395_RS23475	COG0805	protein transport
S101395_RS23480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101395_RS23485	COG3540	Alkaline phosphatase
S101395_RS23495	COG0784	Response regulator, receiver
S101395_RS23500	COG4191	Histidine kinase
S101395_RS23505	COG2066	Belongs to the glutaminase family
S101395_RS23510	COG1115	amino acid carrier protein
S101395_RS23525	COG2205	protein histidine kinase activity
S101395_RS23530	COG0531	amino acid
S101395_RS23545	COG1263	PTS System
S101395_RS23545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS23550	COG3394	polysaccharide catabolic process
S101395_RS23555	COG2188	Transcriptional regulator
S101395_RS23560	COG0363	glucosamine-6-phosphate deaminase activity
S101395_RS23575	COG4257	antibiotic catabolic process
S101395_RS23585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101395_RS23590	COG0371	Dehydrogenase
S101395_RS23610	COG2207	Transcriptional regulator
S101395_RS23610	COG1917	Cupin 2, conserved barrel domain protein
S101395_RS23615	COG0697	spore germination
S101395_RS23625	COG3409	Peptidoglycan-binding domain 1 protein
S101395_RS23645	COG4682	membrane
S101395_RS23650	COG1283	sodium-dependent phosphate transmembrane transporter activity
S101395_RS23660	COG0730	response to heat
S101395_RS23665	COG1802	Transcriptional regulator
S101395_RS23670	COG0778	Nitroreductase
S101395_RS23680	COG2226	methyltransferase
S101395_RS23705	COG2211	Major facilitator Superfamily
S101395_RS23710	COG0596	Alpha beta hydrolase
S101395_RS23715	COG1733	regulation of RNA biosynthetic process
S101395_RS23730	COG0697	spore germination
S101395_RS23735	COG2207	Transcriptional regulator
S101395_RS23735	COG1917	Cupin 2, conserved barrel domain protein
S101395_RS23750	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
S101395_RS23755	COG1331	Highly conserved protein containing a thioredoxin domain
S101395_RS23760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101395_RS23775	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
S101395_RS23780	COG1331	Highly conserved protein containing a thioredoxin domain
S101395_RS23795	COG1331	Highly conserved protein containing a thioredoxin domain
S101395_RS23800	COG1331	Highly conserved protein containing a thioredoxin domain
S101395_RS23835	COG1113	amino acid transport
S101395_RS23840	COG1011	Hydrolase
S101395_RS23860	COG2312	Erythromycin esterase
S101395_RS23870	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S101395_RS23880	COG1131	(ABC) transporter
S101395_RS23895	COG1132	(ABC) transporter
S101395_RS23920	COG1131	(ABC) transporter
S101395_RS23955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101395_RS23960	COG1309	transcriptional regulator
S101395_RS23965	COG2814	Major facilitator Superfamily
S101395_RS23970	COG0640	Transcriptional regulator
S101395_RS23980	COG1725	Transcriptional regulator
S101395_RS24005	COG2723	6-phospho-beta-galactosidase activity
S101395_RS24010	COG2190	(PTS) system
S101395_RS24020	COG2190	(PTS) system
S101395_RS24020	COG1263	PTS System
S101395_RS24020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS24025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S101395_RS24030	COG3958	Transketolase
S101395_RS24035	COG3959	Transketolase, thiamine diphosphate binding domain
S101395_RS24045	COG1609	Transcriptional regulator
S101395_RS24050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S101395_RS24055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101395_RS24060	COG4856	YbbR-like protein
S101395_RS24065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S101395_RS24070	COG5662	AntiSigma factor
S101395_RS24075	COG1595	DNA-templated transcription, initiation
S101395_RS24110	COG1683	Conserved Protein
S101395_RS24115	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S101395_RS24120	COG1737	Transcriptional regulator
S101395_RS24125	COG1263	PTS System
S101395_RS24125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS24130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101395_RS24135	COG1472	Belongs to the glycosyl hydrolase 3 family
S101395_RS24140	COG3876	Protein conserved in bacteria
S101395_RS24145	COG0385	Bile acid
S101395_RS24155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101395_RS24180	COG5444	nuclease activity
S101395_RS24185	COG0457	Tetratricopeptide repeat
S101395_RS24205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101395_RS24210	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S101395_RS24215	COG0463	Glycosyl transferase, family 2
S101395_RS24220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S101395_RS24225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101395_RS24230	COG0753	catalase activity
S101395_RS24230	COG0693	protein deglycase activity
S101395_RS24235	COG2851	Citrate transporter
S101395_RS24240	COG2723	6-phospho-beta-galactosidase activity
S101395_RS24245	COG2190	(PTS) system
S101395_RS24245	COG1263	PTS System
S101395_RS24245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS24250	COG3711	transcriptional antiterminator
S101395_RS24255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S101395_RS24260	COG1122	ATPase activity
S101395_RS24265	COG4721	ABC-type cobalt transport system, permease component
S101395_RS24270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S101395_RS24280	COG3684	Belongs to the aldolase LacD family
S101395_RS24285	COG1105	Belongs to the carbohydrate kinase PfkB family
S101395_RS24290	COG0698	ribose 5-phosphate isomerase
S101395_RS24295	COG0698	ribose 5-phosphate isomerase
S101395_RS24300	COG1349	DNA-binding transcription factor activity
S101395_RS24315	COG3775	system Galactitol-specific IIC component
S101395_RS24320	COG0561	phosphatase activity
S101395_RS24325	COG2224	Isocitrate lyase
S101395_RS24330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
S101395_RS24340	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S101395_RS24345	COG0577	efflux transmembrane transporter activity
S101395_RS24350	COG1136	(ABC) transporter
S101395_RS24355	COG2205	protein histidine kinase activity
S101395_RS24360	COG0745	RESPONSE REGULATOR receiver
S101395_RS24365	COG2723	6-phospho-beta-galactosidase activity
S101395_RS24370	COG2190	(PTS) system
S101395_RS24370	COG1263	PTS System
S101395_RS24370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS24380	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S101395_RS24390	COG3507	Belongs to the glycosyl hydrolase 43 family
S101395_RS24395	COG0513	Belongs to the DEAD box helicase family
S101395_RS24425	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S101395_RS24430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101395_RS24435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S101395_RS24440	COG2390	Transcriptional regulator
S101395_RS24455	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
S101395_RS24460	COG3706	GGDEF domain
S101395_RS24465	COG5298	Protein conserved in bacteria
S101395_RS24470	COG1215	transferase activity, transferring glycosyl groups
S101395_RS24480	COG3977	Valine--pyruvate aminotransferase
S101395_RS24495	COG1181	Belongs to the D-alanine--D-alanine ligase family
S101395_RS24505	COG0191	fructose-bisphosphate aldolase activity
S101395_RS24510	COG1082	Xylose isomerase domain protein TIM barrel
S101395_RS24515	COG1082	Xylose isomerase domain protein TIM barrel
S101395_RS24525	COG2814	Major facilitator Superfamily
S101395_RS24530	COG1082	Xylose isomerase domain protein TIM barrel
S101395_RS24535	COG3962	Belongs to the TPP enzyme family
S101395_RS24540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101395_RS24545	COG3718	enzyme involved in inositol metabolism
S101395_RS24550	COG1012	belongs to the aldehyde dehydrogenase family
S101395_RS24555	COG1349	DNA-binding transcription factor activity
S101395_RS24560	COG0667	Aldo Keto reductase
S101395_RS24565	COG0584	glycerophosphoryl diester phosphodiesterase
S101395_RS24570	COG2271	Major facilitator Superfamily
S101395_RS24575	COG0326	Molecular chaperone. Has ATPase activity
S101395_RS24580	COG0488	(ABC) transporter
S101395_RS24585	COG0561	phosphatase activity
S101395_RS24605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101395_RS24630	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
S101395_RS24635	COG0577	efflux transmembrane transporter activity
S101395_RS24640	COG1136	(ABC) transporter
S101395_RS24645	COG2205	protein histidine kinase activity
S101395_RS24650	COG0745	RESPONSE REGULATOR receiver
S101395_RS24665	COG1115	amino acid carrier protein
S101395_RS24670	COG0686	Belongs to the AlaDH PNT family
S101395_RS24675	COG3867	Arabinogalactan endo-beta-1,4-galactanase
S101395_RS24680	COG1874	Beta-galactosidase
S101395_RS24685	COG3833	ABC-type maltose transport systems, permease component
S101395_RS24690	COG1175	transmembrane transport
S101395_RS24695	COG2182	Extracellular solute-binding protein
S101395_RS24700	COG1609	Transcriptional regulator
S101395_RS24705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S101395_RS24710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S101395_RS24715	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S101395_RS24720	COG1940	carbohydrate kinase activity
S101395_RS24730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101395_RS24750	COG2610	gluconate transmembrane transporter activity
S101395_RS24755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S101395_RS24760	COG1454	alcohol dehydrogenase
S101395_RS24760	COG1012	belongs to the aldehyde dehydrogenase family
S101395_RS24765	COG0450	alkyl hydroperoxide reductase
S101395_RS24770	COG3634	alkyl hydroperoxide reductase activity
S101395_RS24785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101395_RS24790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS24795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101395_RS24810	COG1131	(ABC) transporter
S101395_RS24815	COG0842	Transport permease protein
S101395_RS24820	COG4585	Histidine kinase
S101395_RS24825	COG2197	response regulator
S101395_RS24855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S101395_RS24870	COG0456	acetyltransferase
S101395_RS24885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101395_RS24890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S101395_RS24895	COG4853	Protein conserved in bacteria
S101395_RS24900	COG4863	YycH protein
S101395_RS24905	COG5002	protein histidine kinase activity
S101395_RS24910	COG0745	RESPONSE REGULATOR receiver
S101395_RS24935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
S101395_RS24945	COG0305	Participates in initiation and elongation during chromosome replication
S101395_RS24955	COG3093	addiction module antidote protein HigA
S101395_RS24960	COG2807	transmembrane transport
S101395_RS24965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S101395_RS24970	COG0363	glucosamine-6-phosphate deaminase activity
S101395_RS24975	COG2188	Transcriptional regulator
S101395_RS24980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S101395_RS24985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101395_RS24985	COG1263	PTS System
S101395_RS24990	COG0359	binds to the 23S rRNA
S101395_RS24995	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
S101395_RS25000	COG4241	membrane
S101395_RS25010	COG5577	PFAM Coat F domain
S101395_RS25015	COG0659	secondary active sulfate transmembrane transporter activity
S101395_RS25020	COG2271	Major facilitator Superfamily
S101395_RS25030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S101395_RS25035	COG0629	single-stranded DNA binding
S101395_RS25040	COG0360	Binds together with S18 to 16S ribosomal RNA
S101395_RS25045	COG0012	GTP binding
S101395_RS25050	COG4481	Protein conserved in bacteria
S101395_RS25055	COG3949	Membrane
S101395_RS25065	COG1475	DNA binding
S101395_RS25070	COG1192	Involved in chromosome partitioning
S101395_RS25075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S101395_RS25085	COG1475	DNA binding
S101395_RS25090	COG0357	Ribosomal RNA small subunit methyltransferase G
S101395_RS25095	COG0445	tRNA wobble uridine modification
S101395_RS25100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S101395_RS25105	COG1847	R3H domain protein
S101395_RS25110	COG0706	membrane insertase activity
S101395_RS25115	COG0594	ribonuclease P activity