locus-tag class description GD442_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GD442_RS00015 ENOG410848D S4 domain protein YaaA GD442_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GD442_RS00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GD442_RS00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GD442_RS00100 ENOG4105ZMH deoxynucleoside kinase GD442_RS00110 ENOG4105GTG Isochorismatase GD442_RS00115 ENOG4108Z6B deaminase GD442_RS00125 ENOG4105C6E dna polymerase iii GD442_RS00145 ENOG41067KS pro-sigma K processing GD442_RS00180 ENOG4105CXN decarboxylase GD442_RS00190 ENOG4105FA2 dna polymerase iii GD442_RS00195 ENOG4105MA4 psp1 domain protein GD442_RS00205 ENOG41060K3 Methyltransferase GD442_RS00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GD442_RS00220 ENOG4105KRN Transcriptional regulator, abrb family GD442_RS00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GD442_RS00230 ENOG4105F8V Hydrolase, tatD family GD442_RS00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GD442_RS00245 ENOG4105XFA sporulation peptidase YabG GD442_RS00250 ENOG4105W42 Veg protein GD442_RS00265 ENOG4105DFT pur operon repressor GD442_RS00270 ENOG4105KME endoribonuclease L-psp GD442_RS00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GD442_RS00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GD442_RS00300 ENOG4108JA2 transcriptioN-repair coupling factor GD442_RS00305 ENOG4108M14 stage v sporulation protein t GD442_RS00315 ENOG4108IY2 MazG family GD442_RS00320 ENOG41082I2 s4 domain protein GD442_RS00325 ENOG4105VYY sporulation protein yabp GD442_RS00385 ENOG4105C6T cysteine synthase GD442_RS00390 ENOG4105CRQ synthase (Component I) GD442_RS00395 ENOG4105DDQ anthranilate synthase GD442_RS00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GD442_RS00405 ENOG4105EEI dihydropteroate synthase GD442_RS00410 ENOG4105KRF dihydroneopterin aldolase GD442_RS00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GD442_RS00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GD442_RS00515 ENOG4108Z0C Uvrb UvrC protein GD442_RS00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GD442_RS00535 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GD442_RS00540 ENOG4105CTP PilT protein domain protein GD442_RS00545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GD442_RS00560 ENOG4105D7W serine acetyltransferase GD442_RS00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 GD442_RS00580 ENOG4105M0M Tetracycline resistance protein GD442_RS00585 ENOG4105QIV RNA polymerase GD442_RS00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GD442_RS00625 ENOG4107Y49 methyltransferase GD442_RS00640 ENOG4105XPM ribosomal protein GD442_RS00745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GD442_RS00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GD442_RS00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GD442_RS00790 ENOG41067V7 50S ribosomal protein L36 GD442_RS00815 ENOG4108JJB ABC transporter GD442_RS00820 ENOG4108JJB ABC transporter GD442_RS00825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GD442_RS00830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GD442_RS00855 ENOG4105D1F ATP-binding protein GD442_RS00870 ENOG4108NMV polysaccharide deacetylase GD442_RS00950 ENOG4105C8B TIGR00159 family GD442_RS00955 ENOG4107U5W ybbr family GD442_RS00970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GD442_RS01005 ENOG4108PSK reductase GD442_RS01010 ENOG4108UMI ABC transporter, permease GD442_RS01015 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GD442_RS01020 ENOG4105D01 (LipO)protein GD442_RS01025 ENOG4105EE1 crotonyl-CoA reductase GD442_RS01035 ENOG4105IQ5 FAD linked oxidase domain protein GD442_RS01050 ENOG4105C2C drug resistance transporter, Bcr CflA GD442_RS01085 ENOG4108J59 Extracellular solute-binding protein, family 5 GD442_RS01090 ENOG4108J59 Extracellular solute-binding protein, family 5 GD442_RS01105 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GD442_RS01115 ENOG4105E0C molybdate abc transporter GD442_RS01120 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GD442_RS01125 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GD442_RS01135 ENOG4105EGI Transcriptional regulator GD442_RS01155 ENOG4105F6E Acyl-transferase GD442_RS01175 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GD442_RS01190 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GD442_RS01210 ENOG4105C5H ABC transporter GD442_RS01220 ENOG4105DEF Extracellular solute-binding protein, family 5 GD442_RS01230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD442_RS01235 ENOG4105C3U ABC transporter GD442_RS01240 ENOG4108JQ7 (ABC) transporter GD442_RS01245 ENOG410667J hydrolase GD442_RS01270 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GD442_RS01275 ENOG4105ERH Fumarylacetoacetate hydrolase GD442_RS01285 ENOG4105CUB amino acid GD442_RS01290 ENOG4108SC4 )-transporter GD442_RS01295 ENOG4105CPF Cell wall formation (By similarity) GD442_RS01300 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GD442_RS01325 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GD442_RS01330 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GD442_RS01340 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GD442_RS01445 ENOG4105K8N protein family UPF0079, ATPase GD442_RS01450 ENOG41072GX Peptidase M22 Glycoprotease GD442_RS01455 ENOG410801F ribosomal-protein-alanine acetyltransferase GD442_RS01460 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GD442_RS01465 ENOG4105C5H ABC transporter GD442_RS01480 ENOG4108TYN CAAX amino terminal protease family protein GD442_RS01500 ENOG4105C7N Xanthine uracil vitamin C permease GD442_RS01510 ENOG4105BZU Histidine kinase GD442_RS01535 ENOG4107ZXU DSBA oxidoreductase GD442_RS01580 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_RS01610 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GD442_RS01620 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GD442_RS01630 ENOG4108SHN Glycosyl transferase, family 2 GD442_RS01650 ENOG4105SX7 Transporter GD442_RS01680 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GD442_RS01685 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GD442_RS01690 ENOG4105C83 adenylosuccinate lyase GD442_RS01700 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GD442_RS01725 ENOG4108V3E phosphoribosylglycinamide formyltransferase GD442_RS01735 ENOG4105C12 Phosphoribosylglycinamide synthetase GD442_RS01760 ENOG4105C4R Atp-dependent dna helicase GD442_RS01765 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GD442_RS01785 ENOG4108W2Y isochorismatase GD442_RS01790 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GD442_RS01795 ENOG4108UMI ABC transporter, permease GD442_RS01800 ENOG4105D01 (LipO)protein GD442_RS01820 ENOG410834F Transcriptional regulator GD442_RS01825 ENOG4107I77 yiaA/B two helix domain GD442_RS01845 ENOG4105CBD Diacylglycerol kinase GD442_RS01855 ENOG4108JPW Aminotransferase GD442_RS01865 ENOG4105C26 Dehydrogenase GD442_RS01870 ENOG4105KPY Small multidrug resistance protein GD442_RS01895 ENOG4105D9N nucleoside GD442_RS01900 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GD442_RS01910 ENOG4108W15 Protein of unknown function (DUF1456) GD442_RS01925 ENOG4105DTQ mandelate racemase muconate lactonizing GD442_RS01935 ENOG4105DFD Na H antiporter GD442_RS01960 ENOG4105D3R alkyl hydroperoxide reductase GD442_RS01965 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GD442_RS01970 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GD442_RS01975 ENOG4107W7X Aldolase GD442_RS01980 ENOG4105EHG Permease protein GD442_RS01985 ENOG4105DQ5 transport system permease protein GD442_RS01990 ENOG4108V5C ABC transporter GD442_RS01995 ENOG4105CAY ferredoxin--nadp reductase GD442_RS02010 ENOG4106UIA GD442_RS02015 ENOG4106UIA GD442_RS02030 ENOG4105BZU Histidine kinase GD442_RS02050 ENOG410756H nucleotidyltransferase GD442_RS02070 ENOG4105E5Q amino acid AbC transporter GD442_RS02075 ENOG4105EAB amino acid AbC transporter GD442_RS02080 ENOG4105CDA abc transporter atp-binding protein GD442_RS02085 ENOG4105C8Q Methyl-accepting chemotaxis GD442_RS02100 ENOG4105DBV ornithine carbamoyltransferase GD442_RS02110 ENOG4105C5B carbamate kinase GD442_RS02115 ENOG4108W63 CRP FNR family transcriptional regulator GD442_RS02125 ENOG4105DNP FAD linked oxidase domain protein GD442_RS02135 ENOG4105CI1 PTS System GD442_RS02150 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_RS02165 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GD442_RS02185 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GD442_RS02190 ENOG4105D2X ABC transporter substrate-binding protein GD442_RS02200 ENOG4105C5H ABC transporter GD442_RS02230 ENOG41062JF Transcriptional regulator GD442_RS02245 ENOG4105DEU major facilitator superfamily GD442_RS02260 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GD442_RS02275 ENOG4108N0M stress protein GD442_RS02280 ENOG4106FN3 tellurium resistance protein GD442_RS02285 ENOG4106FN3 tellurium resistance protein GD442_RS02290 ENOG4107TS3 membrane protein, TerC GD442_RS02295 ENOG4108TTB tellurium resistance protein GD442_RS02310 ENOG41068PA UPF0435 protein GD442_RS02315 ENOG4105KJF protein tyrosine phosphatase GD442_RS02325 ENOG4107U9T Pfam:Ribonuclease_BN GD442_RS02330 ENOG4105C59 p-type ATPase GD442_RS02335 ENOG4108IPJ Membrane GD442_RS02345 ENOG4105C3F Signal peptidase i GD442_RS02355 ENOG4107ZTW SNARE associated Golgi GD442_RS02370 ENOG410606W general stress protein GD442_RS02375 ENOG4105UPD Calcium Proton GD442_RS02410 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GD442_RS02415 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GD442_RS02425 ENOG4108JUB Transcriptional regulator GD442_RS02435 ENOG4108IQI permease GD442_RS02470 ENOG4108A04 Beta-lactamase GD442_RS02485 ENOG4105CKK Glycosyl transferase, family 2 GD442_RS02490 ENOG4107QQG Dehydrogenase GD442_RS02495 ENOG4105C3I Nad-dependent epimerase dehydratase GD442_RS02515 ENOG4105F1A Pyruvate formate-lyase GD442_RS02520 ENOG4108QBV Monogalactosyldiacylglycerol synthase GD442_RS02535 ENOG4105CI2 imidazolone-5-propionate hydrolase GD442_RS02540 ENOG4105ECP epimerase GD442_RS02570 ENOG41067AE Membrane-bound metal-dependent hydrolase GD442_RS02575 ENOG4105CEN a g-specific adenine glycosylase GD442_RS02580 ENOG4106BXE GD442_RS02600 ENOG4105BZ1 (ABC) transporter GD442_RS02605 ENOG4107NBY Membrane GD442_RS02610 ENOG4105CBC glutamate synthase GD442_RS02620 ENOG4108IUW ABC transporter GD442_RS02640 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GD442_RS02645 ENOG4105G5W regulator Fur family GD442_RS02755 ENOG4105CDY transcriptional regulatory protein GD442_RS02765 ENOG4108JQC penicillin-binding protein 1A GD442_RS02770 ENOG4108R9S DSBA oxidoreductase GD442_RS02780 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GD442_RS02790 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GD442_RS02795 ENOG4105BZU Histidine kinase GD442_RS02800 ENOG4105CYN Serine protein kinase GD442_RS02805 ENOG4106AKX UPF0229 protein GD442_RS02820 ENOG4105C94 Transporter GD442_RS02835 ENOG4105DZ6 Band 7 protein GD442_RS02845 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GD442_RS02850 ENOG4108V9W transcriptional regulatory protein GD442_RS02855 ENOG4105D4T Citrate transporter GD442_RS02880 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GD442_RS02885 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GD442_RS02890 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GD442_RS02895 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GD442_RS02900 ENOG4105BZ7 extracellular solute-binding protein family 1 GD442_RS02905 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GD442_RS02910 ENOG4108STX response regulator GD442_RS02915 ENOG4105US7 Histidine kinase GD442_RS02940 ENOG4108MRH transcriptional regulatory protein GD442_RS02950 ENOG4105C6K Malic enzyme GD442_RS02960 ENOG4108UZ3 Transporter GD442_RS02965 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GD442_RS02975 ENOG4105BZU Histidine kinase GD442_RS02990 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GD442_RS02995 ENOG4108JB9 formate dehydrogenase GD442_RS03015 ENOG4105CUB amino acid GD442_RS03030 ENOG4105C59 p-type ATPase GD442_RS03035 ENOG4105DAP Nicotinate phosphoribosyltransferase GD442_RS03070 ENOG41073R8 VanW family GD442_RS03075 ENOG4108KGH TRANSCRIPTIONal GD442_RS03080 ENOG4105D9N nucleoside GD442_RS03085 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GD442_RS03090 ENOG4105C37 (CBS) domain GD442_RS03095 ENOG4108IJ0 Aspartate ammonia-lyase GD442_RS03100 ENOG4105DAA L-lactate GD442_RS03115 ENOG4105DUX Transporter GD442_RS03120 ENOG4108MES Periplasmic binding protein GD442_RS03125 ENOG4105DQ5 transport system permease protein GD442_RS03130 ENOG4108IHU transport system permease protein GD442_RS03135 ENOG4105E0A ABC, transporter GD442_RS03145 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GD442_RS03150 ENOG4105EXW epimerase dehydratase GD442_RS03160 ENOG4107T89 von Willebrand factor, type A GD442_RS03165 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GD442_RS03170 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GD442_RS03180 ENOG4105BZU Histidine kinase GD442_RS03185 ENOG4105D5Q Arginine ornithine antiporter GD442_RS03190 ENOG4107414 GntR family transcriptional regulator GD442_RS03195 ENOG4105C5Y PTS System GD442_RS03200 ENOG4105CG3 alpha amylase, catalytic region GD442_RS03215 ENOG4105E1K spore germination protein GD442_RS03225 ENOG4105CRN Aminoglycoside phosphotransferase GD442_RS03230 ENOG4105BZG amino acid carrier protein GD442_RS03235 ENOG4105CDA abc transporter atp-binding protein GD442_RS03240 ENOG4105CT1 (ABC) transporter GD442_RS03245 ENOG4105EAD ABC transporter GD442_RS03250 ENOG4105DRP amino acid AbC transporter GD442_RS03255 ENOG4108IQI permease GD442_RS03280 ENOG4105D29 Helix-turn-helix type 11 domain protein GD442_RS03285 ENOG4105NAE bifunctional deaminase-reductase domain protein GD442_RS03290 ENOG4105BZU Histidine kinase GD442_RS03305 ENOG4105CHH sulfate transporter GD442_RS03310 ENOG41068KF Universal stress protein GD442_RS03320 ENOG4105CXY transporter GD442_RS03325 ENOG41067TZ transcriptional regulator, MarR family GD442_RS03330 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_RS03335 ENOG4105ETE Transcriptional regulator (LacI family GD442_RS03340 ENOG4108RVA ribokinase GD442_RS03350 ENOG4105C2J ABC transporter GD442_RS03355 ENOG4105CNN ABC, transporter GD442_RS03360 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GD442_RS03365 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GD442_RS03395 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) GD442_RS03425 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GD442_RS03430 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GD442_RS03435 ENOG41069ER domain protein GD442_RS03440 ENOG4105VZ8 Transcriptional regulator GD442_RS03460 ENOG4105DUX Transporter GD442_RS03480 ENOG4105C85 amino acid GD442_RS03485 ENOG4105C7N Xanthine uracil vitamin C permease GD442_RS03495 ENOG4105D7V transposase GD442_RS03510 ENOG4105MA6 gCN5-related N-acetyltransferase GD442_RS03535 ENOG4105BZ9 Cytochrome C oxidase, subunit I GD442_RS03540 ENOG4105E2S oxidase) subunit II GD442_RS03560 ENOG4106CAD Protein of unknown function (DUF3311) GD442_RS03565 ENOG4105E1V na solute symporter GD442_RS03580 ENOG4108NHD germination protein GD442_RS03585 ENOG4105CE1 Ferrous iron transport protein b GD442_RS03590 ENOG4105CE1 Ferrous iron transport protein b GD442_RS03595 ENOG4105CE1 Ferrous iron transport protein b GD442_RS03600 ENOG4105CVA phosphate GD442_RS03605 ENOG4105C8U phosphate abc transporter GD442_RS03610 ENOG4105E2Z phosphate ABC transporter (Permease GD442_RS03740 ENOG41080XQ Signal transduction protein with cbs domains GD442_RS03760 ENOG4105ETU transcriptional activator (TenA GD442_RS03770 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GD442_RS03780 ENOG4108VEU Thiamine monophosphate synthase GD442_RS03785 ENOG41080HI glycine oxidase GD442_RS03800 ENOG4105D06 uba thif-type nad fad binding protein GD442_RS03805 ENOG4105DWF phosphomethylpyrimidine kinase GD442_RS03840 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GD442_RS03855 ENOG4108INS Transcriptional regulator GD442_RS03880 ENOG4105C19 ABC transporter GD442_RS03895 ENOG4105CNN ABC, transporter GD442_RS03910 ENOG4105C7N Xanthine uracil vitamin C permease GD442_RS03920 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GD442_RS03940 ENOG4105C5Y PTS System GD442_RS03955 ENOG4105K63 Thioredoxin GD442_RS03975 ENOG4108B31 Spore germination protein GD442_RS03995 ENOG4107Y03 Nitroreductase GD442_RS04000 ENOG4105ED1 spovr family GD442_RS04010 ENOG4105J4Q Transcriptional regulator GD442_RS04025 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GD442_RS04030 ENOG4105XTG Pfam:DUF156 GD442_RS04035 ENOG4105VFE sira family GD442_RS04040 ENOG4107TPS domain protein GD442_RS04045 ENOG4105VFE sira family GD442_RS04050 ENOG4105VFE sira family GD442_RS04055 ENOG41085GJ domain protein GD442_RS04060 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GD442_RS04065 ENOG41087NI Sulfite exporter TauE/SafE GD442_RS04075 ENOG4108KGH TRANSCRIPTIONal GD442_RS04100 ENOG4105EMD TRANSCRIPTIONal GD442_RS04105 ENOG4105VCP PTS System GD442_RS04110 ENOG4105VZJ PTS System GD442_RS04135 ENOG41069ER domain protein GD442_RS04140 ENOG4107RBB ABC transporter, permease GD442_RS04145 ENOG4105C19 ABC transporter GD442_RS04175 ENOG4105WEF catalase GD442_RS04210 ENOG4107T5V SNARE associated Golgi GD442_RS04240 ENOG4105CUB amino acid GD442_RS04245 ENOG4107RWR Sodium hydrogen exchanger GD442_RS04255 ENOG4106KNT transcriptional regulator GD442_RS04260 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GD442_RS04295 ENOG4108YXU transcriptional regulator AsnC family GD442_RS04300 ENOG4105CH7 arginosuccinase GD442_RS04305 ENOG4108IXY short-chain dehydrogenase reductase GD442_RS04315 ENOG4105KPY Small multidrug resistance protein GD442_RS04375 ENOG4107RKG DJ-1/PfpI family GD442_RS04380 ENOG4105CH6 catalase GD442_RS04390 ENOG4105D5Q Arginine ornithine antiporter GD442_RS04395 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GD442_RS04405 ENOG4105C26 Dehydrogenase GD442_RS04410 ENOG4105BZ1 (ABC) transporter GD442_RS04415 ENOG4105BZ1 (ABC) transporter GD442_RS04425 ENOG4105DRP amino acid AbC transporter GD442_RS04430 ENOG4105CDA abc transporter atp-binding protein GD442_RS04445 ENOG410839P GD442_RS04455 ENOG4108UH6 UPF0754 membrane protein GD442_RS04480 ENOG4107FQX Alpha-acetolactate decarboxylase GD442_RS04485 ENOG4108VX5 3-methyladenine DNA glycosylase GD442_RS04500 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GD442_RS04505 ENOG4105D4P Coproporphyrinogen iii oxidase GD442_RS04510 ENOG4105CEY Amp-dependent synthetase and ligase GD442_RS04525 ENOG4105CHH sulfate transporter GD442_RS04550 ENOG4105CGU Enoyl-CoA hydratase GD442_RS04570 ENOG4105DER m42 family GD442_RS04590 ENOG4105CTU Proline racemase GD442_RS04595 ENOG4105CIF Ornithine Cyclodeaminase GD442_RS04610 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD442_RS04620 ENOG4108JQ7 (ABC) transporter GD442_RS04685 ENOG4108IBT Inherit from COG: transposase GD442_RS04725 ENOG4105CSH Transporter GD442_RS04735 ENOG4108MRH transcriptional regulatory protein GD442_RS04780 ENOG4105CDU Replicative dna helicase GD442_RS04800 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_RS04815 ENOG4105D9U N-acetyltransferase GD442_RS04835 ENOG4105F6J Alpha beta hydrolase fold GD442_RS04875 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GD442_RS04895 ENOG4105CMT Dihydroxyacetone kinase GD442_RS04905 ENOG4105CMT Dihydroxyacetone kinase GD442_RS04935 ENOG41069ER domain protein GD442_RS04965 ENOG4108WC5 Alpha Beta Hydrolase Fold protein GD442_RS05005 ENOG4105WN5 stage II sporulation protein GD442_RS05015 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_RS05025 ENOG4108MJI response regulator GD442_RS05030 ENOG4105BZU Histidine kinase GD442_RS05035 ENOG4105BZU Histidine kinase GD442_RS05055 ENOG4105K8R UPF0145 protein GD442_RS05070 ENOG4107QHE Choloylglycine hydrolase GD442_RS05090 ENOG4107VRP DNA repair exonuclease GD442_RS05095 ENOG4106D4I domain protein GD442_RS05125 ENOG4108MUZ hydrolase GD442_RS05145 ENOG4105F0F Oxalate decarboxylase GD442_RS05150 ENOG41067QW Transcriptional regulator GD442_RS05155 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GD442_RS05170 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GD442_RS05190 ENOG4105EEM helicase GD442_RS05200 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GD442_RS05225 ENOG4105K59 histidine triad (HIT) protein GD442_RS05255 ENOG410905X membrane-flanked domain protein GD442_RS05260 ENOG4105CKV Membrane GD442_RS05300 ENOG410905X membrane-flanked domain protein GD442_RS05305 ENOG4105CKV Membrane GD442_RS05310 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GD442_RS05315 ENOG4105BZ4 penicillin-binding protein GD442_RS05325 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GD442_RS05330 ENOG4105C1Q protoporphyrinogen oxidase GD442_RS05355 ENOG4105NA0 Transcriptional regulator GD442_RS05370 ENOG4105ECB domain protein GD442_RS05370 ENOG4105ECB domain protein GD442_RS05385 ENOG4108MK9 spermidine N(1)-acetyltransferase GD442_RS05395 ENOG4106AXD GD442_RS05400 ENOG4108RQ5 Beta-lactamase domain-containing protein GD442_RS05405 ENOG4105DF9 Lipoate-protein, ligase GD442_RS05415 ENOG4105CEY Amp-dependent synthetase and ligase GD442_RS05425 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GD442_RS05430 ENOG4108I5D sulfate abc transporter GD442_RS05435 ENOG4105ECW sulfate abc transporter GD442_RS05440 ENOG4108IJ6 ABC transporter GD442_RS05490 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) GD442_RS05500 ENOG4107RN3 metallophosphoesterase GD442_RS05505 ENOG4107TVP HD domain protein GD442_RS05515 ENOG4108AEY RNA polymerase sigma factor GD442_RS05520 ENOG41086D8 Transcriptional regulator GD442_RS05530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_RS05550 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GD442_RS05555 ENOG4105C8Q Methyl-accepting chemotaxis GD442_RS05560 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GD442_RS05570 ENOG4107QP3 malate synthase g GD442_RS05590 ENOG4105VEQ Cold shock protein GD442_RS05625 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GD442_RS05670 ENOG4105ERH Fumarylacetoacetate hydrolase GD442_RS05680 ENOG4105C8Y Acetylornithine aminotransferase GD442_RS05685 ENOG4106BKT UPF0344 protein GD442_RS05695 ENOG4105CAQ asparagine synthetase GD442_RS05700 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GD442_RS05705 ENOG4105CH6 catalase GD442_RS05710 ENOG4105BZU Histidine kinase GD442_RS05725 ENOG4108VPT UPF0234 protein GD442_RS05730 ENOG4105QNR S1 RNA binding domain protein GD442_RS05735 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GD442_RS05745 ENOG4107AYK membrAne GD442_RS05750 ENOG41073B9 GD442_RS05760 ENOG4108KP7 hydrolase GD442_RS05770 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GD442_RS05795 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GD442_RS05800 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GD442_RS05815 ENOG4105C31 Tryptophanyl-tRNA synthetase GD442_RS05830 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GD442_RS05835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD442_RS05845 ENOG4108JQ7 (ABC) transporter GD442_RS05850 ENOG4105UQX Mate efflux family protein GD442_RS05870 ENOG4108ZCF integral membrane protein GD442_RS05880 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GD442_RS05890 ENOG4105DPN Oligoendopeptidase f GD442_RS05900 ENOG4108Z18 K06886 hemoglobin GD442_RS05905 ENOG4105MIX Adenylate cyclase GD442_RS05910 ENOG4106EFP UPF0738 protein GD442_RS05920 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GD442_RS05925 ENOG4105EMS pseudouridine synthase GD442_RS05945 ENOG4105K64 Glycosyl transferase, family 2 GD442_RS05965 ENOG4107TVC Glycosyl transferase, family 2 GD442_RS05985 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GD442_RS05990 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GD442_RS06000 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GD442_RS06050 ENOG4108ZMI UPF0477 protein GD442_RS06075 ENOG4105CK7 Sodium proline symporter GD442_RS06080 ENOG4105CRQ synthase (Component I) GD442_RS06085 ENOG4105DDQ anthranilate synthase GD442_RS06090 ENOG4108I0Q anthranilate phosphoribosyltransferase GD442_RS06095 ENOG4105DK0 Indole-3-glycerol phosphate synthase GD442_RS06100 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GD442_RS06105 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GD442_RS06110 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GD442_RS06175 ENOG4105C7S Dehydrogenase GD442_RS06180 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GD442_RS06185 ENOG4105VZ8 Transcriptional regulator GD442_RS06245 ENOG4105DZ1 carboxypeptidase GD442_RS06250 ENOG4105VFR signal peptidase GD442_RS06285 ENOG4105C26 Dehydrogenase GD442_RS06290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GD442_RS06295 ENOG4105F38 ABC transporter, permease GD442_RS06300 ENOG4105D38 putrescine abc transporter GD442_RS06305 ENOG4107RUE extracellular solute-binding protein family 1 GD442_RS06315 ENOG4105EYF MMPL domain protein GD442_RS06325 ENOG4108YBP pseudouridine synthase GD442_RS06335 ENOG4105K4I Scp-like extracellular GD442_RS06340 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GD442_RS06345 ENOG4105CQB FAD linked oxidase domain protein GD442_RS06360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS06365 ENOG4105BZU Histidine kinase GD442_RS06370 ENOG4105JXH GntR family transcriptional regulator GD442_RS06390 ENOG4106A3R peptidase GD442_RS06400 ENOG4108QTI )-transporter GD442_RS06405 ENOG4107TS3 membrane protein, TerC GD442_RS06410 ENOG4105CZN Potassium uptake protein GD442_RS06415 ENOG410681C small acid-soluble spore protein GD442_RS06420 ENOG4108Z7G MaoC domain protein dehydratase GD442_RS06440 ENOG4105CHR reductase GD442_RS06465 ENOG4105C4Y ABC transporter GD442_RS06470 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GD442_RS06475 ENOG4107RCV ABC transporter, permease GD442_RS06495 ENOG4105E98 transcriptional regulator DeoR family GD442_RS06505 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GD442_RS06515 ENOG4105PXI polysaccharide deacetylase GD442_RS06525 ENOG4105BZU Histidine kinase GD442_RS06530 ENOG41090MY MarR family Transcriptional regulator GD442_RS06540 ENOG4106DF1 GD442_RS06545 ENOG4105BZU Histidine kinase GD442_RS06550 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GD442_RS06555 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GD442_RS06560 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GD442_RS06595 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GD442_RS06615 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GD442_RS06620 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GD442_RS06625 ENOG4105CZV ABC transporter GD442_RS06635 ENOG4105CJ1 ABC, transporter GD442_RS06675 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GD442_RS06680 ENOG4105EA8 2-Nitropropane dioxygenase GD442_RS06685 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GD442_RS06695 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GD442_RS06715 ENOG4105NQC Flavodoxin GD442_RS06745 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GD442_RS06775 ENOG4105CZN Potassium uptake protein GD442_RS06780 ENOG41063Y9 GD442_RS06785 ENOG4105KBJ sporulation protein ytfj GD442_RS06805 ENOG4105CM2 brancheD-chain amino acid aminotransferase GD442_RS06810 ENOG4105C7K acetolactate synthase GD442_RS06815 ENOG4108ZP8 Acetolactate synthase small subunit GD442_RS06820 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GD442_RS06835 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GD442_RS06850 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GD442_RS06855 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GD442_RS06860 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GD442_RS06865 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GD442_RS06870 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GD442_RS06875 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GD442_RS06885 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase GD442_RS06890 ENOG4107RVV histidinol phosphate phosphatase, hisj family GD442_RS06905 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GD442_RS06910 ENOG4105E0M Sulfatase GD442_RS06920 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GD442_RS06935 ENOG4107S4M Sulfate adenylate transferase GD442_RS06940 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GD442_RS06945 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GD442_RS06955 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GD442_RS06960 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GD442_RS06965 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GD442_RS06970 ENOG4105C8J )-transporter GD442_RS06990 ENOG4105DFD Na H antiporter GD442_RS07010 ENOG4105ENE Histidine kinase GD442_RS07015 ENOG4105WH1 Two component transcriptional regulator luxr family GD442_RS07035 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GD442_RS07060 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GD442_RS07080 ENOG4105CJ3 phosphate transporter GD442_RS07085 ENOG4107GRR phosphate transport regulator GD442_RS07090 ENOG4105BZ4 penicillin-binding protein GD442_RS07105 ENOG4105BZU Histidine kinase GD442_RS07110 ENOG4105I3N Conserved Protein GD442_RS07125 ENOG4105BZU Histidine kinase GD442_RS07130 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GD442_RS07155 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GD442_RS07160 ENOG4105DZ1 carboxypeptidase GD442_RS07165 ENOG4108JIC nucleoside recognition domain protein GD442_RS07175 ENOG4105FE9 pseudouridine synthase GD442_RS07180 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GD442_RS07185 ENOG4107TWT Cytochrome c biogenesis protein GD442_RS07190 ENOG4105CRE cytochrome C GD442_RS07195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS07200 ENOG4105BZU Histidine kinase GD442_RS07205 ENOG4108WBT adenosyltransferase GD442_RS07220 ENOG4108SAX Membrane GD442_RS07235 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_RS07240 ENOG4105I7S Abortive infection protein GD442_RS07250 ENOG4107RGJ metallophosphoesterase GD442_RS07255 ENOG4108XDN Transcriptional regulator GD442_RS07260 ENOG4108S6Z Negative regulator of genetic competence GD442_RS07285 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GD442_RS07290 ENOG4107RB3 L-asparaginase GD442_RS07310 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GD442_RS07325 ENOG4105S2F GD442_RS07330 ENOG41065D1 GD442_RS07360 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GD442_RS07375 ENOG4105XXQ heptaprenyl diphosphate synthase component I GD442_RS07385 ENOG4105EAH synthase GD442_RS07390 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GD442_RS07395 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GD442_RS07400 ENOG4105D49 3-dehydroquinate synthase GD442_RS07410 ENOG41068YB TPR repeat-containing protein GD442_RS07425 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GD442_RS07430 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GD442_RS07465 ENOG4108JYZ YitT family GD442_RS07470 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GD442_RS07475 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GD442_RS07485 ENOG4105FJR Lmbe family GD442_RS07490 ENOG4105CPK Glycosyl transferase (Group 1 GD442_RS07510 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GD442_RS07515 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GD442_RS07525 ENOG4105DVT helicase GD442_RS07530 ENOG4105YAC GD442_RS07550 ENOG4105CSM endonuclease III GD442_RS07560 ENOG4105BZ4 penicillin-binding protein GD442_RS07600 ENOG4106F55 Protein of unknown function (DUF1273) GD442_RS07615 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GD442_RS07625 ENOG4105DVT helicase GD442_RS07630 ENOG4105CTD carboxy-peptidase GD442_RS07640 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GD442_RS07645 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GD442_RS07650 ENOG4105C2W permease GD442_RS07655 ENOG4105DHF Membrane GD442_RS07665 ENOG410890F Dynamin family GD442_RS07675 ENOG4108W0I acetyltransferase GD442_RS07685 ENOG4105KHC sulfurtransferase GD442_RS07740 ENOG4105HTX biosynthesis protein GD442_RS07770 ENOG4105CPK Glycosyl transferase (Group 1 GD442_RS07785 ENOG4108SZE gCN5-related N-acetyltransferase GD442_RS07805 ENOG41081VK Ribonuclease GD442_RS07870 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GD442_RS07880 ENOG4107RWR Sodium hydrogen exchanger GD442_RS07885 ENOG4105CN5 Metallo-Beta-Lactamase GD442_RS07890 ENOG4108Z5V transcriptional regulator, merr family GD442_RS07900 ENOG4105H67 Protein of unknown function (DUF421) GD442_RS07905 ENOG41080C8 DUF218 domain GD442_RS07950 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GD442_RS07960 ENOG4107R0U MotA TolQ exbB proton channel GD442_RS07965 ENOG4105ER2 Ompa motb domain protein GD442_RS07970 ENOG4107YTP response regulator receiver protein GD442_RS07975 ENOG4105CBS Chea signal transduction histidine kinase GD442_RS07980 ENOG4105DD5 Flagellar motor switch protein GD442_RS07995 ENOG4105BZU Histidine kinase GD442_RS08015 ENOG4105E1Q flagellar hook-associated protein GD442_RS08020 ENOG4105DTJ flagellar hook-associated protein GD442_RS08040 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GD442_RS08045 ENOG4108ZC9 flagellar basal-body rod protein flgc GD442_RS08050 ENOG41075Z6 flagellar hook-basal body complex protein fliE GD442_RS08055 ENOG4107U2N Flagellar M-ring protein GD442_RS08060 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GD442_RS08090 ENOG4105BZE flagellar hook protein, FlgE GD442_RS08105 ENOG4107R88 Chemotaxis protein (CheV) GD442_RS08115 ENOG4105I03 Flagellin GD442_RS08120 ENOG4105I03 Flagellin GD442_RS08125 ENOG4105E4C Lytic transglycosylase catalytic GD442_RS08135 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GD442_RS08140 ENOG4105DD5 Flagellar motor switch protein GD442_RS08150 ENOG4105CN7 Flagellar biosynthetic protein FliP GD442_RS08155 ENOG4105VS8 Flagellar biosynthetic protein fliq GD442_RS08165 ENOG4105D00 flagellar biosynthetic protein flhB GD442_RS08170 ENOG4105D7B Flagellar biosynthesis protein flha GD442_RS08175 ENOG4105FZW flagellar biosynthesis regulator FlhF GD442_RS08180 ENOG4105KTQ flagellar basal-body rod protein GD442_RS08185 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GD442_RS08220 ENOG4105KAC Antibiotic biosynthesis monooxygenase GD442_RS08245 ENOG4105DUM transcriptional regulator, lysR family GD442_RS08260 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component GD442_RS08265 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GD442_RS08295 ENOG4105CVJ phosphoglycerate mutase GD442_RS08305 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GD442_RS08325 ENOG4105CAQ asparagine synthetase GD442_RS08345 ENOG4105PGM cation diffusion facilitator family transporter GD442_RS08355 ENOG4105DRR Transcriptional regulator, GntR family GD442_RS08360 ENOG4108UZ3 Transporter GD442_RS08370 ENOG4105CKI cobalamin synthesis protein GD442_RS08375 ENOG4108PJD permease GD442_RS08390 ENOG4105DFD Na H antiporter GD442_RS08395 ENOG4105VUF Transcriptional regulator GD442_RS08405 ENOG4105C9Q fumarate hydratase class II GD442_RS08420 ENOG4107QJQ Mate efflux family protein GD442_RS08425 ENOG4105EC3 peptidase S51, dipeptidase E GD442_RS08445 ENOG4107QIV Cytochrome c biogenesis protein GD442_RS08450 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GD442_RS08460 ENOG4107JM4 Tetratricopeptide repeat GD442_RS08475 ENOG4105BZC d-serine deaminase GD442_RS08480 ENOG4106BRA Membrane GD442_RS08515 ENOG4105CJ1 ABC, transporter GD442_RS08535 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GD442_RS08545 ENOG4108IJ0 Aspartate ammonia-lyase GD442_RS08550 ENOG4105C6K Malic enzyme GD442_RS08600 ENOG4105FVX GD442_RS08615 ENOG4105CSR polyphosphate kinase 2 GD442_RS08620 ENOG4105U3E Transcriptional regulator GD442_RS08630 ENOG4105DXI Major Facilitator superfamily GD442_RS08640 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GD442_RS08645 ENOG4105EU0 Major facilitator Superfamily GD442_RS08650 ENOG4105C6T cysteine synthase GD442_RS08670 ENOG4105C8J )-transporter GD442_RS08680 ENOG4105X5K response regulator receiver protein GD442_RS08685 ENOG4105H67 Protein of unknown function (DUF421) GD442_RS08705 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GD442_RS08710 ENOG4105CHR reductase GD442_RS08715 ENOG4105CM2 brancheD-chain amino acid aminotransferase GD442_RS08720 ENOG4105C7K acetolactate synthase GD442_RS08730 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GD442_RS08735 ENOG4105C01 Dihydroxy-acid dehydratase GD442_RS08740 ENOG4105C7B Threonine dehydratase GD442_RS08765 ENOG4105C6X Major Facilitator GD442_RS08770 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GD442_RS08780 ENOG4105DY9 regulatoR GD442_RS08785 ENOG4105CYC Transferase GD442_RS08800 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GD442_RS08810 ENOG41068WN GD442_RS08815 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GD442_RS08830 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GD442_RS08835 ENOG4105C0X amino acid GD442_RS08880 ENOG410849A acetyltransferase, (GNAT) family GD442_RS08885 ENOG4105K8R UPF0145 protein GD442_RS08900 ENOG4107RHR regulatoR GD442_RS08910 ENOG4105D9N nucleoside GD442_RS08915 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GD442_RS08945 ENOG410811B TRANSCRIPTIONal GD442_RS08960 ENOG4107RAQ aminopeptidase GD442_RS08970 ENOG4107R16 Multicopper oxidase GD442_RS09010 ENOG4108T5E Copper resistance protein GD442_RS09015 ENOG4105KTB nuclear export factor GLE1 GD442_RS09020 ENOG4107RT3 EamA-like transporter family GD442_RS09025 ENOG4105GZI Transcriptional regulator GD442_RS09030 ENOG4108Z40 Transcriptional regulator GD442_RS09035 ENOG4107ZXU DSBA oxidoreductase GD442_RS09040 ENOG4108TVJ Nitroreductase GD442_RS09045 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GD442_RS09050 ENOG4106F5Q Membrane GD442_RS09055 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GD442_RS09065 ENOG4105CKI cobalamin synthesis protein GD442_RS09075 ENOG4105C0Z ABC transporter GD442_RS09080 ENOG4108IV0 ABC, transporter GD442_RS09085 ENOG4105C32 Amino acid ABC transporter (Permease) GD442_RS09095 ENOG4105SKE transcriptional Regulator LysR family GD442_RS09105 ENOG4105MDS 4-oxalocrotonate tautomerase GD442_RS09125 ENOG4105C4M (Ubiquinol oxidase) subunit I GD442_RS09130 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GD442_RS09135 ENOG4108JJ9 ABC, transporter GD442_RS09140 ENOG4108JJ8 (ABC) transporter GD442_RS09150 ENOG4105K64 Glycosyl transferase, family 2 GD442_RS09160 ENOG4108UT6 Transferase hexapeptide repeat containing protein GD442_RS09215 ENOG4105BZ1 (ABC) transporter GD442_RS09220 ENOG4105EFI regulatoR GD442_RS09225 ENOG4105BZU Histidine kinase GD442_RS09235 ENOG41075D4 Aminoglycoside 6-adenylyltransferase GD442_RS09240 ENOG4108ZJ4 polysaccharide deacetylase GD442_RS09260 ENOG4105D6E homoserine dehydrogenase GD442_RS09270 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GD442_RS09285 ENOG4108KGH TRANSCRIPTIONal GD442_RS09295 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_RS09300 ENOG4105BZU Histidine kinase GD442_RS09305 ENOG4107VMI polysaccharide deacetylase GD442_RS09315 ENOG4105KT7 mgtC SapB transporter GD442_RS09320 ENOG4105VRR gCN5-related N-acetyltransferase GD442_RS09330 ENOG4105DUU IucA IucC family protein GD442_RS09335 ENOG4105CEY Amp-dependent synthetase and ligase GD442_RS09350 ENOG4108WBH protein TIM barrel GD442_RS09355 ENOG4105YWU small acid-soluble spore protein GD442_RS09365 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GD442_RS09370 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GD442_RS09420 ENOG4105KRN Transcriptional regulator, abrb family GD442_RS09440 ENOG4105KAF membrAne GD442_RS09465 ENOG4105C8Q Methyl-accepting chemotaxis GD442_RS09480 ENOG4108K88 Membrane GD442_RS09485 ENOG4108WPJ Ferritin-like domain GD442_RS09500 ENOG4105DEN Luciferase family GD442_RS09515 ENOG4105VMI -acetyltransferase GD442_RS09520 ENOG4107QM2 Aldo Keto reductase GD442_RS09525 ENOG4105CKI cobalamin synthesis protein GD442_RS09535 ENOG4105DSE periplasmic solute binding protein GD442_RS09540 ENOG4105K4T epimerase GD442_RS09550 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GD442_RS09595 ENOG4107T5V SNARE associated Golgi GD442_RS09610 ENOG4108PJD permease GD442_RS09620 ENOG4108S4H thioesterase Superfamily protein GD442_RS09630 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GD442_RS09650 ENOG4105SXS Protein of unknown function (DUF456) GD442_RS09655 ENOG4105C37 (CBS) domain GD442_RS09675 ENOG4108Z7R Chaperone CsaA GD442_RS09695 ENOG4108ZRV stage ii sporulation protein p GD442_RS09705 ENOG4108VXD carboxy-peptidase GD442_RS09715 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GD442_RS09735 ENOG4108ZRV stage ii sporulation protein p GD442_RS09745 ENOG4108X4Q Hydrolase GD442_RS09750 ENOG41082F9 transcriptional regulator GD442_RS09755 ENOG4105D94 Major Facilitator Superfamily GD442_RS09765 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GD442_RS09775 ENOG41087PP glycosyltransferase MGT family GD442_RS09780 ENOG4108JYZ YitT family GD442_RS09785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GD442_RS09815 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GD442_RS09835 ENOG4106PAW secretion accessory protein EsaA YueB GD442_RS09845 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) GD442_RS09850 ENOG4108MGT Required for secretion of EsxA and EsxB GD442_RS09930 ENOG4108ZUE Phage regulatory protein rha GD442_RS09980 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GD442_RS09990 ENOG4105KBJ sporulation protein ytfj GD442_RS10015 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GD442_RS10040 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GD442_RS10050 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GD442_RS10055 ENOG4105EMN RNA polymerase sigma factor GD442_RS10070 ENOG4105CNW domain protein GD442_RS10080 ENOG4108V06 Glutathione peroxidase GD442_RS10095 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GD442_RS10105 ENOG4108IUE nitrate reductase beta subunit GD442_RS10110 ENOG4105R3A Nitrate reductase GD442_RS10120 ENOG4107V6Q Cyclic nucleotide-binding domain GD442_RS10125 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GD442_RS10130 ENOG4105D06 uba thif-type nad fad binding protein GD442_RS10135 ENOG4105CVM Molybdenum cofactor synthesis domain protein GD442_RS10140 ENOG4108ZAF Molybdopterin GD442_RS10170 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GD442_RS10175 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GD442_RS10180 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GD442_RS10185 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GD442_RS10190 ENOG4108IFG nitrite reductase, (NAD(P)H) GD442_RS10195 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GD442_RS10230 ENOG4105MCT stage V sporulation protein S GD442_RS10275 ENOG4105C5H ABC transporter GD442_RS10290 ENOG4108UUM single-stranded DNA-binding protein GD442_RS10310 ENOG4107YX5 Pfam:DUF548 GD442_RS10315 ENOG4105C75 arginyL-tRNA synthetase GD442_RS10340 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GD442_RS10365 ENOG4105C5S asparaginyl-tRNA synthetase GD442_RS10370 ENOG4105C8J )-transporter GD442_RS10390 ENOG4107XGZ Hydrolase GD442_RS10395 ENOG4105CY2 Citrate transporter GD442_RS10415 ENOG4105KD7 acetyltransferase GD442_RS10425 ENOG4105VMP Transcriptional regulator GD442_RS10430 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GD442_RS10455 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 GD442_RS10470 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) GD442_RS10475 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GD442_RS10485 ENOG4107RVG penicillin-binding protein GD442_RS10490 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GD442_RS10495 ENOG4105E9Q Acyl-transferase GD442_RS10500 ENOG4108UT2 hemolysin iii GD442_RS10510 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GD442_RS10520 ENOG4108RCR degv family GD442_RS10525 ENOG4107T8T UPF0173 metal-dependent hydrolase GD442_RS10530 ENOG4108KF3 Electron transport protein SCO1 SenC GD442_RS10535 ENOG4107Y70 Heat shock protein GD442_RS10540 ENOG4105CAQ asparagine synthetase GD442_RS10555 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GD442_RS10560 ENOG4108MES Periplasmic binding protein GD442_RS10565 ENOG4105F0I Aminotransferase GD442_RS10590 ENOG4105D8X mechanosensitive ion channel GD442_RS10595 ENOG4105BZU Histidine kinase GD442_RS10600 ENOG4105WH1 Two component transcriptional regulator luxr family GD442_RS10605 ENOG4106KNT transcriptional regulator GD442_RS10610 ENOG4107ZY0 Phenazine biosynthesis-like protein GD442_RS10630 ENOG4105CMG Carbohydrate kinase GD442_RS10635 ENOG4105C6Z Gluconate GD442_RS10645 ENOG4108YV3 Protein of unknown function (DUF2711) GD442_RS10675 ENOG4108IJ8 ABC transporter GD442_RS10680 ENOG4105E90 ABC transporter GD442_RS10715 ENOG4105C37 (CBS) domain GD442_RS10740 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GD442_RS10755 ENOG4107S4Y M20 DapE family protein YgeY GD442_RS10760 ENOG4108TSC N-acetyltransferase GD442_RS10765 ENOG4108JUB Transcriptional regulator GD442_RS10770 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GD442_RS10815 ENOG410841Q phosphoesterase PA-phosphatase related protein GD442_RS10825 ENOG4105SZ6 Thioredoxin GD442_RS10875 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GD442_RS10930 ENOG4105BZ4 penicillin-binding protein GD442_RS10940 ENOG4105CZM Major Facilitator GD442_RS10945 ENOG4105W8X HesB YadR YfhF-family protein GD442_RS10955 ENOG4105DXD 2-methylcitrate dehydratase GD442_RS10960 ENOG4105CR4 methylisocitrate lyase GD442_RS10965 ENOG4105C1G acyl-Coa dehydrogenase GD442_RS10970 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GD442_RS10980 ENOG4105N14 lysine exporter protein LysE YggA GD442_RS10985 ENOG4105E39 Enoyl-CoA hydratase GD442_RS11000 ENOG4107RFY SbcCD D subunit GD442_RS11005 ENOG4105EYH Exonuclease GD442_RS11025 ENOG4105FCD Major Facilitator GD442_RS11030 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GD442_RS11035 ENOG4105E4F Isochorismate synthase GD442_RS11040 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GD442_RS11045 ENOG4105WQI isochorismatase GD442_RS11050 ENOG4105CEY Amp-dependent synthetase and ligase GD442_RS11055 ENOG4105WQT MbtH domain protein GD442_RS11060 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_RS11075 ENOG4105K70 DNA-binding protein GD442_RS11095 ENOG4105BZG amino acid carrier protein GD442_RS11115 ENOG4105FE9 pseudouridine synthase GD442_RS11120 ENOG4105C22 threonyL-tRNA synthetase GD442_RS11125 ENOG4105C19 ABC transporter GD442_RS11180 ENOG41081I9 integral membrane protein GD442_RS11190 ENOG4108Y4K DNA-binding transcriptional activator GD442_RS11210 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GD442_RS11220 ENOG4105EYF MMPL domain protein GD442_RS11245 ENOG4105WCN acetyltransferase GD442_RS11270 ENOG4105C1Q protoporphyrinogen oxidase GD442_RS11280 ENOG41068WN GD442_RS11310 ENOG4107V2S Transcriptional regulator GD442_RS11315 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GD442_RS11335 ENOG4105DND Transcriptional regulator GD442_RS11340 ENOG4108RPX mosc domain containing protein GD442_RS11355 ENOG4105BZ1 (ABC) transporter GD442_RS11360 ENOG4105BZ1 (ABC) transporter GD442_RS11390 ENOG4108JCI Transcriptional regulator GD442_RS11420 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GD442_RS11425 ENOG4108KPJ rna polymerase sigma factor GD442_RS11445 ENOG4105F32 YngK protein GD442_RS11465 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GD442_RS11470 ENOG4105RD7 BadF BadG BcrA BcrD GD442_RS11475 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GD442_RS11480 ENOG4107STF Involved in phosphonate degradation (By similarity) GD442_RS11485 ENOG4105C7B Threonine dehydratase GD442_RS11490 ENOG4108INS Transcriptional regulator GD442_RS11510 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GD442_RS11525 ENOG4105C1J atp-dependent rna helicase GD442_RS11535 ENOG4108RZE Tetr family transcriptional regulator GD442_RS11640 ENOG41088CC tellurite resistance protein tehB GD442_RS11650 ENOG4108I0C methyltransferase GD442_RS11655 ENOG4107RA9 decarboxylase GD442_RS11660 ENOG4105K56 Transcriptional regulator GD442_RS11665 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GD442_RS11690 ENOG4105CIN aminoacyl-histidine dipeptidase GD442_RS11720 ENOG4105KRN Transcriptional regulator, abrb family GD442_RS11730 ENOG4105EJ9 Membrane GD442_RS11735 ENOG4105EQK -acetyltransferase GD442_RS11775 ENOG4105W8Z 4'-phosphopantetheinyl transferase GD442_RS11835 ENOG4105FQP Beta-lactamase GD442_RS11840 ENOG4107RVG penicillin-binding protein GD442_RS11855 ENOG4107RF6 penicillin-binding protein GD442_RS11860 ENOG4107RF6 penicillin-binding protein GD442_RS11880 ENOG4105CJ1 ABC, transporter GD442_RS11890 ENOG4107Z3H Transcriptional regulator, TetR family GD442_RS11905 ENOG4105C1G acyl-Coa dehydrogenase GD442_RS11910 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GD442_RS11915 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GD442_RS11920 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GD442_RS11925 ENOG4105E39 Enoyl-CoA hydratase GD442_RS11930 ENOG4107QX3 carboxylase GD442_RS11935 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GD442_RS11955 ENOG4105DBI uridine monophosphokinase GD442_RS11975 ENOG4105DZ1 carboxypeptidase GD442_RS11990 ENOG4105T9C HD domain GD442_RS12000 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GD442_RS12020 ENOG41075H3 AraC family transcriptional regulator GD442_RS12050 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GD442_RS12060 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GD442_RS12065 ENOG4105KVH Transcriptional regulator GD442_RS12115 ENOG4105EFA 4-hydroxyphenylacetate GD442_RS12130 ENOG4105CPQ Dehydrogenase GD442_RS12140 ENOG410900G Protein of unknown function (DUF421) GD442_RS12145 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GD442_RS12155 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GD442_RS12165 ENOG4105DK7 lysyl-tRNA synthetase GD442_RS12175 ENOG4108VQT Alpha beta hydrolase fold protein GD442_RS12215 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GD442_RS12250 ENOG4105D6E homoserine dehydrogenase GD442_RS12260 ENOG4105CPF Cell wall formation (By similarity) GD442_RS12265 ENOG4105ETU transcriptional activator (TenA GD442_RS12355 ENOG410667J hydrolase GD442_RS12360 ENOG4105BZU Histidine kinase GD442_RS12365 ENOG4107RF6 penicillin-binding protein GD442_RS12390 ENOG4108JJB ABC transporter GD442_RS12405 ENOG4108HGU Histidine kinase GD442_RS12420 ENOG4105CB2 alcohol dehydrogenase GD442_RS12425 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GD442_RS12430 ENOG4105CJN penicillin-binding protein GD442_RS12475 ENOG4107Y80 Major Facilitator superfamily GD442_RS12480 ENOG4108Z5V transcriptional regulator, merr family GD442_RS12500 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GD442_RS12525 ENOG4107Y9U Membrane GD442_RS12565 ENOG4105FCD Major Facilitator GD442_RS12575 ENOG4105E09 nadh pyrophosphatase GD442_RS12580 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GD442_RS12600 ENOG4108XI2 Domain of unknown function (DUF1963) GD442_RS12620 ENOG4108NRW Phospholipase, patatin family GD442_RS12625 ENOG4105KWG Pfam:DUF1696 GD442_RS12635 ENOG4108YYS metal-dependent hydrolase (By similarity) GD442_RS12650 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GD442_RS12660 ENOG4105PKS Excinuclease abc c subunit domain protein GD442_RS12700 ENOG4107VFR oxidoreductase GD442_RS12730 ENOG4105U0R haloacid dehalogenase-like hydrolase GD442_RS12735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS12740 ENOG4105BZU Histidine kinase GD442_RS12760 ENOG4107WD8 ABC transporter, permease GD442_RS12775 ENOG4108IUM Glycogen debranching enzyme GD442_RS12785 ENOG4105CGH 5'-nucleotidase GD442_RS12800 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GD442_RS12805 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GD442_RS12810 ENOG4105FDR Membrane GD442_RS12820 ENOG4105CIS alcohol dehydrogenase GD442_RS12825 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GD442_RS12870 ENOG4105MSI germination protein ypeb GD442_RS12900 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) GD442_RS12905 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GD442_RS12910 ENOG4107Z3H Transcriptional regulator, TetR family GD442_RS12930 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GD442_RS12945 ENOG4105E98 transcriptional regulator DeoR family GD442_RS12960 ENOG41062ES Transcriptional regulator GD442_RS12980 ENOG4107QKR Dehydrogenase GD442_RS12990 ENOG4107RUY (E1 component), alpha subunit GD442_RS13000 ENOG4105E1F short-chain dehydrogenase reductase GD442_RS13005 ENOG4105RHY Pfam:UPF0157 GD442_RS13045 ENOG4107SQ8 Glycine betaine GD442_RS13050 ENOG4108IJ7 Glycine betaine GD442_RS13060 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GD442_RS13075 ENOG4105E66 phosphoriboisomerase A GD442_RS13080 ENOG41082BV acetyltransferase GD442_RS13085 ENOG4108M1A Chitin-binding protein GD442_RS13115 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GD442_RS13120 ENOG4105MSB protein, conserved in bacteria GD442_RS13140 ENOG4108Z7F N-acetyltransferase GD442_RS13160 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GD442_RS13165 ENOG4105EEM helicase GD442_RS13180 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_RS13225 ENOG4108M1A Chitin-binding protein GD442_RS13245 ENOG4105BZG amino acid carrier protein GD442_RS13250 ENOG4105C26 Dehydrogenase GD442_RS13255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GD442_RS13260 ENOG4105CTU Proline racemase GD442_RS13265 ENOG4105CTU Proline racemase GD442_RS13270 ENOG41080HI glycine oxidase GD442_RS13280 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GD442_RS13310 ENOG4107T5V SNARE associated Golgi GD442_RS13320 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GD442_RS13340 ENOG4105DTQ mandelate racemase muconate lactonizing GD442_RS13355 ENOG4107SET aldo keto reductase GD442_RS13390 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) GD442_RS13395 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GD442_RS13400 ENOG4105BZU Histidine kinase GD442_RS13405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS13430 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GD442_RS13445 ENOG4105DPN Oligoendopeptidase f GD442_RS13450 ENOG4105EPR degv family GD442_RS13510 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GD442_RS13515 ENOG4106K7D Major facilitator family transporter GD442_RS13535 ENOG4107BMA Transglycosylase associated protein GD442_RS13550 ENOG41089UC methyltransferase, type 11 GD442_RS13585 ENOG4105CHM Aminotransferase GD442_RS13615 ENOG4105DVE abc transporter atp-binding protein GD442_RS13665 ENOG4105C02 permease GD442_RS13675 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GD442_RS13680 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GD442_RS13685 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein GD442_RS13690 ENOG4105D7T ABC transporter GD442_RS13725 ENOG4108AQF aminoglycoside N(3)-acetyltransferase GD442_RS13760 ENOG4107VC0 DNA alkylation repair enzyme GD442_RS13765 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_RS13775 ENOG4107VMI polysaccharide deacetylase GD442_RS13785 ENOG4108ZCF integral membrane protein GD442_RS13790 ENOG4105E0M Sulfatase GD442_RS13795 ENOG4105C5H ABC transporter GD442_RS13805 ENOG4105EYF MMPL domain protein GD442_RS13810 ENOG41082JN Transcriptional regulator GD442_RS13830 ENOG4105CIH Imidazole acetol-phosphate transaminase GD442_RS13835 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GD442_RS13840 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GD442_RS13885 ENOG41069ER domain protein GD442_RS13895 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_RS13925 ENOG4105D4B ABC, transporter GD442_RS13930 ENOG4105F5R ABC transporter GD442_RS13935 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GD442_RS13945 ENOG4105DKT Transcriptional regulator GD442_RS13950 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) GD442_RS13960 ENOG41061GT Aldolase GD442_RS13970 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GD442_RS14005 ENOG4105II7 pyrroline-5-carboxylate reductase GD442_RS14015 ENOG4107258 Transcriptional regulator GD442_RS14030 ENOG4105ECK Fatty Acid Desaturase GD442_RS14040 ENOG4107RBI VanW family GD442_RS14045 ENOG4105G6Z alkaline phosphatase GD442_RS14055 ENOG4105VMP Transcriptional regulator GD442_RS14075 ENOG41068WN GD442_RS14105 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GD442_RS14130 ENOG4105CKK Glycosyl transferase, family 2 GD442_RS14160 ENOG4105C8Y Acetylornithine aminotransferase GD442_RS14205 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GD442_RS14250 ENOG4108IBT Inherit from COG: transposase GD442_RS14270 ENOG4108TVJ Nitroreductase GD442_RS14275 ENOG4105FS7 Transcriptional regulator GD442_RS14290 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GD442_RS14295 ENOG4105WEC Molybdate metabolism regulator GD442_RS14305 ENOG4105CMR udp-glucose 4-epimerase GD442_RS14315 ENOG4108DMH HTH_ARAC GD442_RS14320 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GD442_RS14325 ENOG4108XET gCN5-related N-acetyltransferase GD442_RS14340 ENOG4108PCN EamA-like transporter family GD442_RS14360 ENOG4107XJU UPF0178 protein GD442_RS14400 ENOG410635A Membrane GD442_RS14410 ENOG4108IQI permease GD442_RS14420 ENOG4105F1N DNA alkylation repair GD442_RS14455 ENOG4107RF6 penicillin-binding protein GD442_RS14460 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GD442_RS14485 ENOG4105E7W lamb ycsf family protein GD442_RS14495 ENOG4105P4J Allophanate hydrolase, subunit 1 GD442_RS14500 ENOG4107258 Transcriptional regulator GD442_RS14510 ENOG4106N3A copper homeostasis protein cutc GD442_RS14515 ENOG4108ZHR arsR family transcriptional regulator GD442_RS14525 ENOG4105FDT acyl-CoA dehydrogenase GD442_RS14540 ENOG4105DWD nucleoside recognition domain protein GD442_RS14585 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GD442_RS14610 ENOG4105E2A Dehydrogenase GD442_RS14615 ENOG4108IJ0 Aspartate ammonia-lyase GD442_RS14620 ENOG4105HDK L-asparaginase GD442_RS14625 ENOG4108IMY Transcriptional regulator GD442_RS14650 ENOG4108B31 Spore germination protein GD442_RS14660 ENOG4105BZU Histidine kinase GD442_RS14685 ENOG41075H3 AraC family transcriptional regulator GD442_RS14700 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GD442_RS14705 ENOG4105CUB amino acid GD442_RS14710 ENOG4105II7 pyrroline-5-carboxylate reductase GD442_RS14715 ENOG4108NHD germination protein GD442_RS14720 ENOG4108Q8B Spore germination protein GD442_RS14755 ENOG4106A3M Cytochrome p-450 GD442_RS14770 ENOG4105CGH 5'-nucleotidase GD442_RS14780 ENOG4105CHJ isochorismatase hydrolase GD442_RS14805 ENOG41090MY MarR family Transcriptional regulator GD442_RS14830 ENOG4105F6J Alpha beta hydrolase fold GD442_RS14845 ENOG4108606 TspO/MBR family GD442_RS14850 ENOG4105CVP deoxyribo-dipyrimidine photolyase GD442_RS14875 ENOG4108TWJ NADH dehydrogenase subunit 5 GD442_RS14880 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GD442_RS14895 ENOG4105E1K spore germination protein GD442_RS14900 ENOG4107VMI polysaccharide deacetylase GD442_RS14905 ENOG4105KY5 gCN5-related N-acetyltransferase GD442_RS14910 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GD442_RS14920 ENOG4105Z7P Acetyltransferase (GNAT) family GD442_RS14930 ENOG4105D6J arsenicaL-resistance protein GD442_RS14935 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_RS14940 ENOG41085FC arsR family transcriptional regulator GD442_RS14950 ENOG4105NAE bifunctional deaminase-reductase domain protein GD442_RS14955 ENOG4107P5I polyketide synthase GD442_RS14960 ENOG4108IG5 Transcriptional regulator GD442_RS14965 ENOG4105F27 Major Facilitator GD442_RS14970 ENOG4105M4P Tetr family transcriptional regulator GD442_RS14975 ENOG4105CHR reductase GD442_RS14980 ENOG4108YXU transcriptional regulator AsnC family GD442_RS15070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS15075 ENOG41062D9 Histidine kinase GD442_RS15115 ENOG4105C19 ABC transporter GD442_RS15145 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GD442_RS15150 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_RS15165 ENOG4105K6H D-cysteine desulfhydrase GD442_RS15180 ENOG4105JQZ Methyltransferase GD442_RS15195 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) GD442_RS15215 ENOG4105BZU Histidine kinase GD442_RS15225 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GD442_RS15235 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GD442_RS15280 ENOG4105C44 Serine transporter GD442_RS15285 ENOG4105EJQ L-serine dehydratase GD442_RS15300 ENOG4108JPW Aminotransferase GD442_RS15315 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GD442_RS15325 ENOG4105DVH amino acid GD442_RS15340 ENOG4108JQ1 Dehydrogenase GD442_RS15345 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GD442_RS15360 ENOG41082W1 Cupin 2, conserved barrel domain protein GD442_RS15365 ENOG410874W AraC family transcriptional regulator GD442_RS15385 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GD442_RS15495 ENOG4108VXD carboxy-peptidase GD442_RS15500 ENOG4105PNM synthesis protein GD442_RS15510 ENOG4108ISG Major Facilitator GD442_RS15525 ENOG4107MII Sugar-specific transcriptional regulator TrmB GD442_RS15530 ENOG4105CZM Major Facilitator GD442_RS15540 ENOG4105CRW Short chain fatty acid transporter GD442_RS15550 ENOG4105DYS nad(p)h dehydrogenase (quinone) GD442_RS15610 ENOG4108K8S endonuclease I GD442_RS15625 ENOG4108Z66 YbaK ebsC protein GD442_RS15630 ENOG4105CUT histidyl-tRNA synthetase GD442_RS15645 ENOG4105KVH Transcriptional regulator GD442_RS15650 ENOG4108RCM Nitroreductase GD442_RS15680 ENOG4108PSK reductase GD442_RS15745 ENOG4105C31 Tryptophanyl-tRNA synthetase GD442_RS15750 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GD442_RS15780 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GD442_RS15790 ENOG4105EV4 Multidrug resistance protein mdtH GD442_RS15820 ENOG4105C37 (CBS) domain GD442_RS15835 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GD442_RS15840 ENOG4105FAW cDP-glucose 4,6-dehydratase GD442_RS15875 ENOG4105DDN Pentapeptide repeat-containing protein GD442_RS15880 ENOG4105XDF Protein of unknown function (DUF1272) GD442_RS15885 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GD442_RS15890 ENOG4105CMG Carbohydrate kinase GD442_RS15895 ENOG4105C6Z Gluconate GD442_RS15910 ENOG4105CV1 Transketolase (EC 2.2.1.1) GD442_RS15915 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GD442_RS15925 ENOG4105CIS alcohol dehydrogenase GD442_RS15930 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GD442_RS15940 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GD442_RS15955 ENOG4105C8Q Methyl-accepting chemotaxis GD442_RS15960 ENOG4108UX3 '-nucleotidase GD442_RS15965 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GD442_RS15970 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GD442_RS15975 ENOG4105KVH Transcriptional regulator GD442_RS15990 ENOG4105CV8 reductase GD442_RS15995 ENOG4105F27 Major Facilitator GD442_RS16005 ENOG41090KN UPF0303 protein GD442_RS16020 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GD442_RS16025 ENOG4105CHH sulfate transporter GD442_RS16040 ENOG4105C44 Serine transporter GD442_RS16070 ENOG4105KVH Transcriptional regulator GD442_RS16075 ENOG4108TZY GntR Family Transcriptional Regulator GD442_RS16080 ENOG4105D9R oxidoreductase GD442_RS16085 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GD442_RS16090 ENOG4105KVH Transcriptional regulator GD442_RS16095 ENOG4105KVH Transcriptional regulator GD442_RS16140 ENOG4105JAB phenazine biosynthesis protein, phzf family GD442_RS16150 ENOG4108RU0 short-chain dehydrogenase reductase GD442_RS16165 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GD442_RS16170 ENOG4105KVH Transcriptional regulator GD442_RS16180 ENOG4108ZJ4 polysaccharide deacetylase GD442_RS16235 ENOG4105KAF membrAne GD442_RS16260 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GD442_RS16270 ENOG4107YXZ hydrolase, family 25 GD442_RS16305 ENOG4105H3G oxidoreductase GD442_RS16370 ENOG4108TN2 lmbE family GD442_RS16380 ENOG4107R3E Citrate transporter GD442_RS16395 ENOG4108MES Periplasmic binding protein GD442_RS16400 ENOG4105EHG Permease protein GD442_RS16405 ENOG4105DQ5 transport system permease protein GD442_RS16410 ENOG4105NX3 Membrane GD442_RS16430 ENOG41068WN GD442_RS16435 ENOG4107CUJ Protein of unknown function (DUF2690) GD442_RS16445 ENOG4107V2S Transcriptional regulator GD442_RS16465 ENOG4105C98 muts2 protein GD442_RS16475 ENOG4105E5K Alpha-amylase GD442_RS16480 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GD442_RS16485 ENOG4105DPN Oligoendopeptidase f GD442_RS16505 ENOG4105FFC UPF0187 protein GD442_RS16520 ENOG4108A04 Beta-lactamase GD442_RS16545 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GD442_RS16555 ENOG41082BM Transcriptional regulator, arsr family GD442_RS16560 ENOG4105CIS alcohol dehydrogenase GD442_RS16585 ENOG4105CQB FAD linked oxidase domain protein GD442_RS16610 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GD442_RS16615 ENOG4107TPS domain protein GD442_RS16620 ENOG4105CEP NADH dehydrogenase GD442_RS16630 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GD442_RS16640 ENOG4108IAJ Nad-dependent epimerase dehydratase GD442_RS16645 ENOG4105FAW cDP-glucose 4,6-dehydratase GD442_RS16690 ENOG4105BZU Histidine kinase GD442_RS16695 ENOG4105C5H ABC transporter GD442_RS16720 ENOG4105BZU Histidine kinase GD442_RS16730 ENOG4105KT7 mgtC SapB transporter GD442_RS16740 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_RS16745 ENOG41073R8 VanW family GD442_RS16755 ENOG4108R1P GD442_RS16770 ENOG4105VEQ Cold shock protein GD442_RS16810 ENOG410904N short-chain dehydrogenase reductase GD442_RS16820 ENOG4106IQC argininosuccinate lyase GD442_RS16835 ENOG4108IA2 Sodium pantothenate symporter GD442_RS16845 ENOG4105C26 Dehydrogenase GD442_RS16850 ENOG4105CHR reductase GD442_RS16860 ENOG4105EWU Squalene--hopene cyclase GD442_RS16870 ENOG4105FR1 rard protein GD442_RS16875 ENOG410696E Membrane GD442_RS16890 ENOG4105D1F ATP-binding protein GD442_RS16900 ENOG4108ZAF Molybdopterin GD442_RS16905 ENOG4105CVM Molybdenum cofactor synthesis domain protein GD442_RS16910 ENOG4105D06 uba thif-type nad fad binding protein GD442_RS16915 ENOG4105TMB Formate nitrite transporter GD442_RS16925 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GD442_RS16930 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) GD442_RS16940 ENOG4108JB9 formate dehydrogenase GD442_RS16945 ENOG4105E1K spore germination protein GD442_RS16960 ENOG4105CUB amino acid GD442_RS17015 ENOG4107QJT sodium dicarboxylate symporter GD442_RS17020 ENOG4108KGH TRANSCRIPTIONal GD442_RS17030 ENOG4105EMN RNA polymerase sigma factor GD442_RS17040 ENOG4105CIG ABC transporter GD442_RS17060 ENOG4105D9R oxidoreductase GD442_RS17070 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GD442_RS17075 ENOG4105K4P CoA-binding domain protein GD442_RS17080 ENOG4105C0H protease GD442_RS17085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS17095 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GD442_RS17100 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GD442_RS17105 ENOG4105W8X HesB YadR YfhF-family protein GD442_RS17135 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GD442_RS17140 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GD442_RS17150 ENOG4108JJA ABC, transporter GD442_RS17155 ENOG4108I0Z Aconitate hydratase GD442_RS17185 ENOG4105E5W Transporter GD442_RS17195 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GD442_RS17215 ENOG4107F3J Amp-dependent synthetase and ligase GD442_RS17220 ENOG4107ZYJ bioY protein GD442_RS17225 ENOG4105CEY Amp-dependent synthetase and ligase GD442_RS17270 ENOG4107AYK membrAne GD442_RS17280 ENOG4105BZU Histidine kinase GD442_RS17285 ENOG4105FBA Phospholipase Carboxylesterase GD442_RS17290 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GD442_RS17295 ENOG4105CK7 Sodium proline symporter GD442_RS17305 ENOG4105CBC glutamate synthase GD442_RS17310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GD442_RS17315 ENOG4108VJ1 Transcriptional regulator (CarD family GD442_RS17320 ENOG4108903 Formimidoylglutamase GD442_RS17375 ENOG4107QIV Cytochrome c biogenesis protein GD442_RS17385 ENOG4105CH2 amidohydrolase GD442_RS17395 ENOG4105CJ1 ABC, transporter GD442_RS17410 ENOG4107RSM transcriptional regulator GD442_RS17415 ENOG4105VAW lrga family GD442_RS17420 ENOG41067MG lrgb family GD442_RS17460 ENOG4105BZ1 (ABC) transporter GD442_RS17465 ENOG4105BZ1 (ABC) transporter GD442_RS17500 ENOG4108HW3 (ABC) transporter GD442_RS17505 ENOG4105CGH 5'-nucleotidase GD442_RS17515 ENOG4108SVB resolvase GD442_RS17535 ENOG4105K7K Transcriptional regulator GD442_RS17540 ENOG4105C5F glutamine synthetase GD442_RS17545 ENOG4105KV4 Transcriptional regulator GD442_RS17550 ENOG4105CXI aluminum resistance protein GD442_RS17555 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GD442_RS17560 ENOG4105EN6 Membrane GD442_RS17565 ENOG4106F1P AAA ATPase, central domain protein GD442_RS17595 ENOG41069ER domain protein GD442_RS17600 ENOG4105DM4 PTS System GD442_RS17605 ENOG4105DE4 1-phosphofructokinase GD442_RS17610 ENOG4105E98 transcriptional regulator DeoR family GD442_RS17615 ENOG4107QW4 alcohol dehydrogenase GD442_RS17620 ENOG4108SJC Membrane GD442_RS17630 ENOG4105C85 amino acid GD442_RS17645 ENOG4105TMB Formate nitrite transporter GD442_RS17650 ENOG4105K70 DNA-binding protein GD442_RS17660 ENOG4105C59 p-type ATPase GD442_RS17665 ENOG410681U heavy metal transport detoxification protein GD442_RS17670 ENOG4105VPX protein, conserved in bacteria GD442_RS17680 ENOG4105NIV Esterase GD442_RS17685 ENOG4105E0A ABC, transporter GD442_RS17705 ENOG4105CGK Exodeoxyribonuclease III GD442_RS17715 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GD442_RS17720 ENOG4105D03 DNA-3-methyladenine glycosylase II GD442_RS17725 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GD442_RS17745 ENOG4105BZU Histidine kinase GD442_RS17785 ENOG41067MG lrgb family GD442_RS17805 ENOG4108S3Y transcriptional regulator GD442_RS17810 ENOG4105CS2 ec 3.2.1.21 GD442_RS17825 ENOG4105F0V Cell wall hydrolase GD442_RS17835 ENOG4105E0M Sulfatase GD442_RS17840 ENOG410890F Dynamin family GD442_RS17875 ENOG4105DQU oxidoreductase, subunit beta GD442_RS17880 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GD442_RS17885 ENOG4108IGT Dipeptidase GD442_RS17890 ENOG4105MCT stage V sporulation protein S GD442_RS17895 ENOG4105D48 metallophosphoesterase GD442_RS17910 ENOG4105CEV competence damage-inducible protein GD442_RS17915 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GD442_RS17930 ENOG4105XZV Protein of unknown function (DUF3243) GD442_RS17935 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GD442_RS17955 ENOG4105UIB (ABC) transporter GD442_RS17960 ENOG4108JQ9 ABC transporter GD442_RS17965 ENOG4105DIH basic membrane GD442_RS17970 ENOG4105FDP GntR family transcriptional regulator GD442_RS17975 ENOG4105CNU cell division protein FtsK GD442_RS17985 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GD442_RS17995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GD442_RS18005 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GD442_RS18010 ENOG4108S0H Dipicolinic acid synthetase, b subunit GD442_RS18030 ENOG4108IBT Inherit from COG: transposase GD442_RS18205 ENOG4105CDU Replicative dna helicase GD442_RS18245 ENOG4108IMY Transcriptional regulator GD442_RS18275 ENOG4105E35 Dipicolinate synthase subunit A GD442_RS18285 ENOG4105C1V Peptidase, M16 GD442_RS18305 ENOG4105DTN riboflavin biosynthesis protein ribF GD442_RS18320 ENOG4105W7A Protein of unknown function (DUF503) GD442_RS18330 ENOG4105VHM ribosomal protein GD442_RS18335 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GD442_RS18340 ENOG4105CHV Transcription elongation factor NusA GD442_RS18350 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GD442_RS18360 ENOG4105DZP Membrane-associated zinc metalloprotease GD442_RS18365 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GD442_RS18370 ENOG4105KNE Phosphatidate cytidylyltransferase GD442_RS18375 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GD442_RS18385 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GD442_RS18415 ENOG4108HE4 integrase family GD442_RS18420 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GD442_RS18425 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GD442_RS18430 ENOG4105C79 DNA protecting protein DprA GD442_RS18435 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GD442_RS18450 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GD442_RS18475 ENOG4105VB6 UPF0109 protein GD442_RS18495 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GD442_RS18500 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GD442_RS18515 ENOG4105CHR reductase GD442_RS18520 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GD442_RS18535 ENOG4105CB5 ATP-dependent DNA helicase recG GD442_RS18540 ENOG4105DP4 dak2 domain fusion protein ylov GD442_RS18545 ENOG4108ZAA Alkaline-shock protein GD442_RS18560 ENOG4105FJ0 thiamine GD442_RS18565 ENOG4105DJV ribulose-phosphate 3-epimerase GD442_RS18570 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GD442_RS18575 ENOG4105D9P serine threonine protein kinase GD442_RS18580 ENOG4108ZF3 Phosphatase GD442_RS18585 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GD442_RS18590 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GD442_RS18605 ENOG4105C25 Primosomal protein n' GD442_RS18610 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GD442_RS18630 ENOG4105DSJ YicC domain protein GD442_RS18640 ENOG4105F23 Fibronectin-binding protein GD442_RS18645 ENOG4105DC7 peptidase M24 GD442_RS18665 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GD442_RS18680 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GD442_RS18685 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GD442_RS18695 ENOG4105CD3 dihydroorotase GD442_RS18715 ENOG4105C34 Pseudouridine synthase GD442_RS18730 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GD442_RS18740 ENOG4105DBK s4 domain protein GD442_RS18745 ENOG41067XK integral membrane protein GD442_RS18755 ENOG4105DFA alanine racemase domain protein GD442_RS18760 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GD442_RS18765 ENOG4105WR5 sporulation protein, YlmC YmxH family GD442_RS18775 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_RS18785 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GD442_RS18790 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GD442_RS18800 ENOG4105D4A Cell wall formation (By similarity) GD442_RS18805 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GD442_RS18810 ENOG4105CNI cell division protein FtsW GD442_RS18815 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GD442_RS18825 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GD442_RS18830 ENOG4105CJN penicillin-binding protein GD442_RS18835 ENOG4105CJN penicillin-binding protein GD442_RS18850 ENOG41074B2 UPF0747 protein GD442_RS18875 ENOG4105KNH Nucleic acid-binding protein GD442_RS18885 ENOG41063PX domain protein GD442_RS18890 ENOG4105D78 K07001 NTE family protein GD442_RS18895 ENOG4105H20 Sporulation integral membrane protein YlbJ GD442_RS18905 ENOG4106H78 methyltransferase GD442_RS18930 ENOG4107TB6 phosphoglycerate mutase GD442_RS18945 ENOG4106UY4 Inherit from COG: Scp-like extracellular GD442_RS18990 ENOG4107VFP cytochrome oxidase assembly GD442_RS18995 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GD442_RS19000 ENOG4105CNI cell division protein FtsW GD442_RS19015 ENOG4108IAB Phoh family GD442_RS19035 ENOG4105QA2 GD442_RS19040 ENOG4105CI3 gtp-binding protein typa GD442_RS19050 ENOG4105ECY inositol monophosphatase GD442_RS19070 ENOG4105CXN decarboxylase GD442_RS19120 ENOG4105CPP Dehydrogenase, E1 component GD442_RS19135 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GD442_RS19140 ENOG4108X4Q Hydrolase GD442_RS19150 ENOG4105CN5 Metallo-Beta-Lactamase GD442_RS19155 ENOG4107ZYR domain protein GD442_RS19190 ENOG4108XRC Protein of unknown function (DUF458) GD442_RS19195 ENOG4107IN1 Protein of unknown function (DUF1797) GD442_RS19210 ENOG4105EPM Diguanylate phosphodiesterase GD442_RS19215 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GD442_RS19230 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GD442_RS19245 ENOG4105UIN GD442_RS19280 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GD442_RS19300 ENOG4108HGU Histidine kinase GD442_RS19310 ENOG4105CHM Aminotransferase GD442_RS19315 ENOG4105FKQ transcriptional regulator GD442_RS19320 ENOG4105EG2 ABC transporter, permease GD442_RS19330 ENOG4107FKK extracellular solute-binding protein family 1 GD442_RS19340 ENOG4105CG3 alpha amylase, catalytic region GD442_RS19385 ENOG4105CHU acetyl-coa acetyltransferase GD442_RS19420 ENOG4105K7K Transcriptional regulator GD442_RS19425 ENOG4105DTD Dehydrogenase GD442_RS19445 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GD442_RS19455 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GD442_RS19470 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GD442_RS19485 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GD442_RS19495 ENOG4105BZU Histidine kinase GD442_RS19515 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GD442_RS19530 ENOG4105CID antiterminator GD442_RS19540 ENOG4105FDP GntR family transcriptional regulator GD442_RS19550 ENOG4105CE4 GlcNAc 6-P deacetylase GD442_RS19585 ENOG4107ZE5 PPIases accelerate the folding of proteins GD442_RS19590 ENOG4105PTM secreted protein GD442_RS19595 ENOG4105J7I hydrolase GD442_RS19605 ENOG4105G6R Stage v sporulation protein ae GD442_RS19615 ENOG4105CZ3 stage V sporulation protein ad GD442_RS19620 ENOG41090VF Stage v sporulation protein ac GD442_RS19640 ENOG4105C8J )-transporter GD442_RS19645 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_RS19655 ENOG41082AN stage II sporulation protein GD442_RS19660 ENOG4105DZ1 carboxypeptidase GD442_RS19665 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GD442_RS19670 ENOG4105DVE abc transporter atp-binding protein GD442_RS19705 ENOG4105D7N magnesium and cobalt transport protein CorA GD442_RS19730 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GD442_RS19740 ENOG4105I3K Ferric uptake regulator, Fur family GD442_RS19745 ENOG4105MZ9 stage II sporulation protein m GD442_RS19765 ENOG4105CPC Aldo Keto reductase GD442_RS19775 ENOG4105RHY Pfam:UPF0157 GD442_RS19795 ENOG4107SKW Inherit from COG: Alpha beta hydrolase GD442_RS19805 ENOG4105ETE Transcriptional regulator (LacI family GD442_RS19810 ENOG4108YM7 Gcn5-related n-acetyltransferase GD442_RS19830 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GD442_RS19835 ENOG4108R6K riboflavin synthase, subunit alpha GD442_RS19860 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GD442_RS19865 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GD442_RS19875 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GD442_RS19880 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GD442_RS19890 ENOG4105DFD Na H antiporter GD442_RS19895 ENOG4105CGH 5'-nucleotidase GD442_RS19920 ENOG4105DBV ornithine carbamoyltransferase GD442_RS19935 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GD442_RS19950 ENOG4108IXY short-chain dehydrogenase reductase GD442_RS19955 ENOG41069FQ Metallo-beta-lactamase superfamily GD442_RS19960 ENOG4105II7 pyrroline-5-carboxylate reductase GD442_RS19965 ENOG4105EJQ L-serine dehydratase GD442_RS19980 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GD442_RS19995 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GD442_RS20010 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GD442_RS20015 ENOG4105D9U N-acetyltransferase GD442_RS20030 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GD442_RS20035 ENOG4108QEG Membrane GD442_RS20040 ENOG4105CDA abc transporter atp-binding protein GD442_RS20045 ENOG4105E5Q amino acid AbC transporter GD442_RS20050 ENOG4108HW3 (ABC) transporter GD442_RS20060 ENOG4105G7B Protein of unknown function (DUF2992) GD442_RS20070 ENOG4108QY0 Membrane GD442_RS20080 ENOG4105C7S Dehydrogenase GD442_RS20085 ENOG4105CPP Dehydrogenase, E1 component GD442_RS20100 ENOG4105CKM Branched-chain carboxylic acid kinase GD442_RS20105 ENOG4107RDP Dehydrogenase GD442_RS20115 ENOG4108JUB Transcriptional regulator GD442_RS20125 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GD442_RS20140 ENOG4107QQR Sporulation GD442_RS20145 ENOG4105S1Z Stage IV sporulation protein B GD442_RS20150 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GD442_RS20155 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GD442_RS20160 ENOG4105DX0 Hemolysin A GD442_RS20170 ENOG4105CTB Polyprenyl synthetase GD442_RS20185 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GD442_RS20195 ENOG4108ZSR alkaline shock protein GD442_RS20200 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GD442_RS20225 ENOG410644B Stage III sporulation protein af GD442_RS20235 ENOG4105KQ4 Stage iii sporulation protein ad GD442_RS20240 ENOG4108CQH stage III sporulation protein AC GD442_RS20245 ENOG4105KR5 Stage iii sporulation protein GD442_RS20250 ENOG4105CD2 stage iii sporulation protein aa GD442_RS20275 ENOG4105DC7 peptidase M24 GD442_RS20280 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GD442_RS20290 ENOG4105CBJ Metal-dependent enzyme GD442_RS20300 ENOG4107YBY Hydrolase GD442_RS20330 ENOG41082GG biotin lipoate A B protein ligase GD442_RS20335 ENOG4105WZW rhodanese family GD442_RS20360 ENOG41080TC multidrug resistance protein GD442_RS20390 ENOG4105CJ1 ABC, transporter GD442_RS20395 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GD442_RS20425 ENOG4105C0D helicase GD442_RS20505 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GD442_RS20510 ENOG4105XSJ toxin secretion phage lysis holin GD442_RS20665 ENOG4105DVF Cytosine-specific methyltransferase GD442_RS20715 ENOG4105KRN Transcriptional regulator, abrb family GD442_RS20820 ENOG4107R6U sodium dicarboxylate symporter GD442_RS20855 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GD442_RS20860 ENOG4105C3R Methionine synthase GD442_RS20870 ENOG4105C28 cystathionine GD442_RS20875 ENOG4105C28 cystathionine GD442_RS20895 ENOG4105C5X domain protein GD442_RS20905 ENOG4105DKQ ROK family GD442_RS20915 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GD442_RS20935 ENOG4108UTW Plays a role in the regulation of phosphate uptake GD442_RS20940 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GD442_RS20945 ENOG4105C8U phosphate abc transporter GD442_RS20950 ENOG4105C8U phosphate abc transporter GD442_RS20955 ENOG4105EXS phosphate abc transporter GD442_RS20960 ENOG4107RF6 penicillin-binding protein GD442_RS20970 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GD442_RS20995 ENOG4105N80 Ferric uptake regulator, Fur family GD442_RS21005 ENOG4105FDK ABC transporter GD442_RS21010 ENOG4108JYZ YitT family GD442_RS21015 ENOG41069ZM Protein of unknown function (DUF2624) GD442_RS21040 ENOG4105EGD dinuclear metal center protein, YbgI family GD442_RS21055 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_RS21060 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GD442_RS21085 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GD442_RS21090 ENOG4105KG3 cytidine deaminase GD442_RS21095 ENOG4107YR5 Diacylglycerol kinase GD442_RS21100 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GD442_RS21105 ENOG4105CTJ Metal Dependent Phosphohydrolase GD442_RS21110 ENOG4105C9A Phoh family GD442_RS21120 ENOG41068P3 sporulation protein YqfC GD442_RS21125 ENOG4105KTH gatB Yqey GD442_RS21135 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GD442_RS21140 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GD442_RS21170 ENOG4105CSA Coproporphyrinogen iii oxidase GD442_RS21175 ENOG4105KVH Transcriptional regulator GD442_RS21200 ENOG4105TQK DNA polymerase iii, delta' subunit GD442_RS21210 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GD442_RS21215 ENOG4108UK2 deaminase GD442_RS21220 ENOG4105KQC Competence protein GD442_RS21230 ENOG4105DXX methyltransferase GD442_RS21240 ENOG4108WF2 Metal Dependent Phosphohydrolase GD442_RS21250 ENOG410812S Rna-binding protein GD442_RS21260 ENOG4105CQW ribosome biogenesis GTPase YqeH GD442_RS21265 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GD442_RS21280 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_RS21300 ENOG4108TVJ Nitroreductase GD442_RS21315 ENOG4105G6Z alkaline phosphatase GD442_RS21320 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GD442_RS21325 ENOG4108MUZ hydrolase GD442_RS21365 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GD442_RS21370 ENOG4105MIR Phenylalanine 4-monooxygenase GD442_RS21380 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_RS21420 ENOG4105S6R Iron-hydroxamate transporter permease subunit GD442_RS21425 ENOG4108V5C ABC transporter GD442_RS21435 ENOG4108EKI Dehydrogenase GD442_RS21440 ENOG4105C28 cystathionine GD442_RS21470 ENOG4107XRG penicillin-binding protein GD442_RS21480 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GD442_RS21490 ENOG4105CFP Peptidase U32 GD442_RS21495 ENOG4105XYU peptidase (U32 family) GD442_RS21500 ENOG4108VQJ O-methyltransferase GD442_RS21505 ENOG4105HHA aminodeoxychorismate lyase GD442_RS21525 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GD442_RS21535 ENOG4105C02 permease GD442_RS21550 ENOG41060CR GD442_RS21555 ENOG4105C7H Helicase, RecD TraA family GD442_RS21565 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GD442_RS21570 ENOG4105C3J Cysteine desulfurase GD442_RS21580 ENOG4105D1H recombination factor protein RarA GD442_RS21585 ENOG4108VCI transcription factor, rsfa family GD442_RS21590 ENOG4105CUZ uba thif-type nad fad binding protein GD442_RS21600 ENOG4105CUT histidyl-tRNA synthetase GD442_RS21605 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GD442_RS21610 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GD442_RS21620 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GD442_RS21625 ENOG41076HS cation diffusion facilitator family transporter GD442_RS21630 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GD442_RS21640 ENOG4105CKP Polysaccharide Biosynthesis Protein GD442_RS21645 ENOG4108QG2 Membrane GD442_RS21655 ENOG4105VIE preprotein translocase, subunit YajC GD442_RS21670 ENOG41061AI Protein of unknown function (DUF2905) GD442_RS21685 ENOG4108HUF Transporter GD442_RS21710 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GD442_RS21715 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GD442_RS21720 ENOG4108IYU L-aspartate oxidase GD442_RS21735 ENOG4108RPX mosc domain containing protein GD442_RS21740 ENOG4105CQC Prephenate dehydratase GD442_RS21755 ENOG4105C19 ABC transporter GD442_RS21760 ENOG4105EWM Histidine kinase GD442_RS21770 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GD442_RS21790 ENOG4105C03 ribonuclease GD442_RS21805 ENOG4107QMS site-determining protein GD442_RS21820 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GD442_RS21825 ENOG4105DFF Rod shape-determining protein mreb GD442_RS21845 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GD442_RS21850 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GD442_RS21860 ENOG41068KH stage VI sporulation protein D GD442_RS21870 ENOG4105D52 delta-aminolevulinic acid dehydratase GD442_RS21895 ENOG4105K56 Transcriptional regulator GD442_RS21915 ENOG4108IUQ atp-dependent protease GD442_RS21940 ENOG4108QCI YvbH-like oligomerisation region GD442_RS21960 ENOG4105M59 Phosphodiesterase, mj0936 family GD442_RS21965 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GD442_RS21975 ENOG4108XJQ germination protein GD442_RS21985 ENOG4108PCX Major Facilitator GD442_RS21995 ENOG4105KBX Transcriptional regulator, TetR family GD442_RS22005 ENOG4105PFC Transcriptional regulator GD442_RS22080 ENOG4105PFC Transcriptional regulator GD442_RS22090 ENOG4105DZC cytosine deaminase GD442_RS22095 ENOG41067S9 phage shock protein C, PspC GD442_RS22100 ENOG4108JCI Transcriptional regulator GD442_RS22110 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GD442_RS22115 ENOG4108Z40 Transcriptional regulator GD442_RS22120 ENOG4105RHA ABC transporter, permease GD442_RS22125 ENOG4108IUX (ABC) transporter GD442_RS22130 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family GD442_RS22135 ENOG4105ER2 Ompa motb domain protein GD442_RS22140 ENOG4105E14 MotA TolQ exbB proton channel GD442_RS22145 ENOG4108VXD carboxy-peptidase GD442_RS22155 ENOG4105E33 succinate dehydrogenase GD442_RS22165 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GD442_RS22175 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GD442_RS22180 ENOG4105K63 Thioredoxin GD442_RS22185 ENOG4105C10 Electron transfer flavoprotein GD442_RS22190 ENOG4105BZJ Electron transfer flavoprotein GD442_RS22195 ENOG41060WC Enoyl-CoA hydratase GD442_RS22200 ENOG4107Z3H Transcriptional regulator, TetR family GD442_RS22205 ENOG4105CEY Amp-dependent synthetase and ligase GD442_RS22215 ENOG4105J76 Periplasmic binding protein GD442_RS22220 ENOG4105S6R Iron-hydroxamate transporter permease subunit GD442_RS22265 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_RS22275 ENOG4105DR4 Methyltransferase GD442_RS22285 ENOG4105KFN sortase, SrtB family GD442_RS22290 ENOG4105E0A ABC, transporter GD442_RS22305 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) GD442_RS22315 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) GD442_RS22325 ENOG4105FE9 pseudouridine synthase GD442_RS22335 ENOG4105DCG PHP domain protein GD442_RS22350 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GD442_RS22370 ENOG4105C5S asparaginyl-tRNA synthetase GD442_RS22375 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GD442_RS22385 ENOG4108RWN rrna methyltransferase GD442_RS22415 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_RS22420 ENOG4105CW7 secretion protein, HlyD family GD442_RS22425 ENOG4108JGH Tetr family transcriptional regulator GD442_RS22430 ENOG4105CN9 Peptidase m42 family protein GD442_RS22450 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GD442_RS22455 ENOG4105C22 threonyL-tRNA synthetase GD442_RS22460 ENOG4108TDW sporulation protein YtxC GD442_RS22485 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GD442_RS22490 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GD442_RS22495 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GD442_RS22505 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GD442_RS22510 ENOG4105C2M dna polymerase I GD442_RS22515 ENOG4105BZU Histidine kinase GD442_RS22520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_RS22530 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GD442_RS22535 ENOG4108HMX isocitrate dehydrogenase (NADP) GD442_RS22540 ENOG4105BZN citrate synthase GD442_RS22550 ENOG4108REF Sporulation integral membrane protein ytvi GD442_RS22555 ENOG4105FS0 cytoplasmic membrane protein GD442_RS22580 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GD442_RS22585 ENOG4105C6K Malic enzyme GD442_RS22590 ENOG4105C0B DNA polymerase III (alpha subunit) GD442_RS22595 ENOG4105VV2 GD442_RS22605 ENOG4105SFS phosphoesterase RecJ domain protein GD442_RS22625 ENOG4105E8R UPF0173 metal-dependent hydrolase GD442_RS22630 ENOG4105DC7 peptidase M24 GD442_RS22670 ENOG4105Z7P Acetyltransferase (GNAT) family GD442_RS22675 ENOG41082W1 Cupin 2, conserved barrel domain protein GD442_RS22695 ENOG4107YZX Universal stress protein GD442_RS22700 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_RS22720 ENOG4105CH7 arginosuccinase GD442_RS22740 ENOG4108JYZ YitT family GD442_RS22760 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GD442_RS22770 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GD442_RS22775 ENOG4105KBJ sporulation protein ytfj GD442_RS22790 ENOG4105EFZ amidohydrolase GD442_RS22800 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GD442_RS22825 ENOG4106KR7 LysR family Transcriptional regulator GD442_RS22835 ENOG4105U5Y Transcriptional regulator GD442_RS22845 ENOG4105C28 cystathionine GD442_RS22865 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GD442_RS22870 ENOG4108UW5 maltose o-acetyltransferase GD442_RS22880 ENOG4105F1V Acetoin utilization protein GD442_RS22885 ENOG4105W87 Cbs domain GD442_RS22890 ENOG4105DGU Histone deacetylase GD442_RS22905 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_RS22915 ENOG4107SNB ankyrin repeat protein YahD GD442_RS22920 ENOG4105EP9 oxidoreductase GD442_RS22950 ENOG4105ETE Transcriptional regulator (LacI family GD442_RS22955 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GD442_RS22975 ENOG4105C88 aminopeptidase GD442_RS23020 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GD442_RS23030 ENOG4108VDD TRNA binding domain protein GD442_RS23060 ENOG4105C8F Beta-lactamase domain protein GD442_RS23075 ENOG4108V15 phosphotransferase enzyme family GD442_RS23080 ENOG4108IUM Glycogen debranching enzyme GD442_RS23090 ENOG4107QSE Dipeptidase GD442_RS23095 ENOG4105YW5 deoR family transcriptional regulator GD442_RS23110 ENOG4105CBX hi0933 family GD442_RS23145 ENOG4108VJ1 Transcriptional regulator (CarD family GD442_RS23150 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GD442_RS23155 ENOG4105CSC Glucose uptake protein GD442_RS23170 ENOG4108ZAF Molybdopterin GD442_RS23175 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GD442_RS23180 ENOG4105CVM Molybdenum cofactor synthesis domain protein GD442_RS23190 ENOG4105D06 uba thif-type nad fad binding protein GD442_RS23195 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GD442_RS23215 ENOG41085GJ domain protein GD442_RS23225 ENOG4105DWV Homoserine O-trans-acetylase GD442_RS23235 ENOG4108B31 Spore germination protein GD442_RS23260 ENOG4105C8T Leucyl-tRNA synthetase GD442_RS23265 ENOG410605W Major Facilitator GD442_RS23270 ENOG4107S91 Sodium hydrogen exchanger GD442_RS23275 ENOG4105NCW Trka-c domain protein GD442_RS23290 ENOG4105C19 ABC transporter GD442_RS23310 ENOG4105N5T Radical SAM Protein GD442_RS23340 ENOG4105E8V Alpha Beta Hydrolase Fold protein GD442_RS23345 ENOG4108Z0R Transferase GD442_RS23350 ENOG4105YVM Phosphoesterase, PA-phosphatase related GD442_RS23355 ENOG4105BZF Glycosyl transferase (Group 1 GD442_RS23365 ENOG4105EPU Molybdenum cofactor synthesis domain protein GD442_RS23375 ENOG4108MK9 spermidine N(1)-acetyltransferase GD442_RS23425 ENOG4105BZU Histidine kinase GD442_RS23430 ENOG4105BZU Histidine kinase GD442_RS23445 ENOG4107S9D Alpha beta hydrolase GD442_RS23450 ENOG4107T7U Sulfatase GD442_RS23470 ENOG4105D2X ABC transporter substrate-binding protein GD442_RS23480 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GD442_RS23545 ENOG4108V2W Carbonate dehydratase GD442_RS23550 ENOG4105C4M (Ubiquinol oxidase) subunit I GD442_RS23555 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GD442_RS23590 ENOG41087YS Phage shock protein A GD442_RS23620 ENOG4105BZU Histidine kinase GD442_RS23625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS23650 ENOG4108UGV hypoxanthine phosphoribosyltransferase GD442_RS23655 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GD442_RS23680 ENOG4105C19 ABC transporter GD442_RS23695 ENOG4107ZTW SNARE associated Golgi GD442_RS23700 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GD442_RS23710 ENOG4105C19 ABC transporter GD442_RS23715 ENOG41086D8 Transcriptional regulator GD442_RS23730 ENOG41082BM Transcriptional regulator, arsr family GD442_RS23780 ENOG4105C6Z Gluconate GD442_RS23785 ENOG4105FDP GntR family transcriptional regulator GD442_RS23805 ENOG41069H0 dihydroorotase EC 3.5.2.3 GD442_RS23825 ENOG4105DTQ mandelate racemase muconate lactonizing GD442_RS23830 ENOG4105CEY Amp-dependent synthetase and ligase GD442_RS23835 ENOG4108IPT Naphthoate synthase GD442_RS23840 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GD442_RS23845 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GD442_RS23850 ENOG4105E4F Isochorismate synthase GD442_RS23855 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GD442_RS23865 ENOG4105VEQ Cold shock protein GD442_RS23895 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GD442_RS23900 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GD442_RS23910 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GD442_RS23915 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GD442_RS24010 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GD442_RS24045 ENOG4105KT7 mgtC SapB transporter GD442_RS24050 ENOG4107PBV potassium channel GD442_RS24065 ENOG4105WG9 Conserved Protein GD442_RS24075 ENOG4105CHM Aminotransferase GD442_RS24080 ENOG4108ZB6 transcriptional regulator AsnC family GD442_RS24085 ENOG4105C5I Dehydrogenase GD442_RS24090 ENOG4108MUZ hydrolase GD442_RS24100 ENOG4105C87 Aminotransferase class I and II GD442_RS24110 ENOG4105Y38 Kinase-associated protein B GD442_RS24120 ENOG4107R3E Citrate transporter GD442_RS24135 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GD442_RS24140 ENOG4105KA0 thioesterase Superfamily protein GD442_RS24155 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GD442_RS24175 ENOG41069ER domain protein GD442_RS24190 ENOG4105CEP NADH dehydrogenase GD442_RS24220 ENOG4105EWC Purine nucleoside phosphorylase GD442_RS24240 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GD442_RS24265 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GD442_RS24270 ENOG4105C4B ABC transporter, permease GD442_RS24275 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GD442_RS24305 ENOG41083MR nifu domain-containing protein GD442_RS24320 ENOG4108W5N phosphatidylglycerophosphatase a GD442_RS24340 ENOG4105DAX Pfam:DUF2983 GD442_RS24350 ENOG4105DYS nad(p)h dehydrogenase (quinone) GD442_RS24355 ENOG4105D4U had-superfamily hydrolase, subfamily iia GD442_RS24370 ENOG4105CBT Fructose-1,6-bisphosphatase GD442_RS24385 ENOG4105MMD transcriptional regulator GD442_RS24390 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GD442_RS24395 ENOG4107TXC Transcriptional regulator GD442_RS24400 ENOG41090T1 Membrane GD442_RS24425 ENOG4105FAA peptidase M23 GD442_RS24430 ENOG4108YTE sporulation protein YunB GD442_RS24435 ENOG4105KZD Domain of unknown function (DUF1805) GD442_RS24440 ENOG4107R8B 5'-nucleotidase GD442_RS24445 ENOG4105DIW FeS assembly protein SUFB GD442_RS24450 ENOG4108UNV SUF system FeS assembly protein, NifU family GD442_RS24455 ENOG4105C9B Cysteine desulfurase GD442_RS24460 ENOG4105JRK feS assembly protein SufD GD442_RS24465 ENOG4105C3K feS assembly ATPase SufC GD442_RS24470 ENOG4105D01 (LipO)protein GD442_RS24475 ENOG4105D01 (LipO)protein GD442_RS24480 ENOG4108UMI ABC transporter, permease GD442_RS24510 ENOG41080E8 Transcriptional regulator, Spx MgsR family GD442_RS24530 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GD442_RS24555 ENOG4108W8B Beta-lactamase domain protein GD442_RS24560 ENOG4105C1G acyl-Coa dehydrogenase GD442_RS24565 ENOG4105CHU acetyl-coa acetyltransferase GD442_RS24580 ENOG4105DZ1 carboxypeptidase GD442_RS24600 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GD442_RS24605 ENOG4105D7V transposase GD442_RS24620 ENOG4108SUT Major Facilitator Superfamily GD442_RS24625 ENOG4107R7I amino acid GD442_RS24640 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GD442_RS24650 ENOG4107AYK membrAne GD442_RS24685 ENOG4107ZTW SNARE associated Golgi GD442_RS24695 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GD442_RS24700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS24705 ENOG4105BZU Histidine kinase GD442_RS24720 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GD442_RS24735 ENOG4105C8Q Methyl-accepting chemotaxis GD442_RS24740 ENOG4105VG1 fes assembly suf system protein GD442_RS24745 ENOG4105D4Y metalloprotease GD442_RS24765 ENOG4107T5V SNARE associated Golgi GD442_RS24770 ENOG4107S91 Sodium hydrogen exchanger GD442_RS24775 ENOG4105NCW Trka-c domain protein GD442_RS24785 ENOG4108RMU ferritin dps family protein GD442_RS24800 ENOG4108URH decarboxylase GD442_RS24810 ENOG41090A1 ferritin GD442_RS24820 ENOG4105D9N nucleoside GD442_RS24825 ENOG4105D9N nucleoside GD442_RS24840 ENOG4108RYK Nad-dependent epimerase dehydratase GD442_RS24855 ENOG4105CV8 reductase GD442_RS24860 ENOG4105F27 Major Facilitator GD442_RS24865 ENOG4105KVH Transcriptional regulator GD442_RS24880 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GD442_RS24885 ENOG4105D4A Cell wall formation (By similarity) GD442_RS24905 ENOG4105WMR Protein CrcB homolog GD442_RS24910 ENOG4105WMR Protein CrcB homolog GD442_RS24930 ENOG4105C5H ABC transporter GD442_RS24935 ENOG4108MK9 spermidine N(1)-acetyltransferase GD442_RS24940 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GD442_RS24975 ENOG4108IPW abc transporter atp-binding protein GD442_RS24980 ENOG4105CM4 permease protein GD442_RS25010 ENOG4105ST3 Transcriptional regulator GD442_RS25025 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GD442_RS25035 ENOG4105XZU Preprotein translocase, subunit SecG GD442_RS25040 ENOG41067MG lrgb family GD442_RS25060 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GD442_RS25090 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_RS25110 ENOG41090VF Stage v sporulation protein ac GD442_RS25115 ENOG4105CZ3 stage V sporulation protein ad GD442_RS25130 ENOG4108QY0 Membrane GD442_RS25135 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GD442_RS25140 ENOG4105KRI phosphocarrier protein (HPr GD442_RS25150 ENOG4105CHW UPF0052 protein GD442_RS25155 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GD442_RS25160 ENOG4108Z4K mutator MutT protein GD442_RS25170 ENOG4105C3M thioredoxin reductase GD442_RS25180 ENOG4108S4C acetyltransferase GD442_RS25190 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GD442_RS25200 ENOG41086DT Membrane protein of unknown function GD442_RS25205 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GD442_RS25210 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GD442_RS25225 ENOG4107TXC Transcriptional regulator GD442_RS25240 ENOG4105HMI Membrane GD442_RS25245 ENOG4105DUM transcriptional regulator, lysR family GD442_RS25255 ENOG4108WS4 fmn reductase GD442_RS25260 ENOG4105C5H ABC transporter GD442_RS25270 ENOG4105BZ1 (ABC) transporter GD442_RS25280 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GD442_RS25285 ENOG4107RSM transcriptional regulator GD442_RS25295 ENOG4105CN1 protease GD442_RS25300 ENOG4105CRP Part of the ABC transporter FtsEX involved in GD442_RS25305 ENOG4105CAK Cell division ATP-binding protein ftsE GD442_RS25325 ENOG4105MS2 ribosomal subunit Interface protein GD442_RS25330 ENOG4105VEQ Cold shock protein GD442_RS25335 ENOG41081UC Inherit from COG: Competence protein GD442_RS25345 ENOG4105K4H Nlp p60 protein GD442_RS25350 ENOG4105KVH Transcriptional regulator GD442_RS25360 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GD442_RS25365 ENOG4108KGH TRANSCRIPTIONal GD442_RS25370 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GD442_RS25375 ENOG4105C6Y Udp-glucose 6-dehydrogenase GD442_RS25380 ENOG4105ESV Glycosyl transferase, family 4 GD442_RS25390 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GD442_RS25410 ENOG4105F8D glycoside hydrolase family 4 GD442_RS25415 ENOG4105VCP PTS System GD442_RS25420 ENOG4105CK1 PTS System GD442_RS25430 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GD442_RS25435 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GD442_RS25440 ENOG4105VCP PTS System GD442_RS25450 ENOG4105VZJ PTS System GD442_RS25470 ENOG4105ECB domain protein GD442_RS25475 ENOG4107RSM transcriptional regulator GD442_RS25505 ENOG4105DAA L-lactate GD442_RS25515 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) GD442_RS25525 ENOG4105E0M Sulfatase GD442_RS25550 ENOG4107R8N Glycosyl transferase, family 2 GD442_RS25555 ENOG4105C94 Transporter GD442_RS25560 ENOG41069ER domain protein GD442_RS25585 ENOG4105KBK Zinc finger, swim domain protein GD442_RS25590 ENOG4105C0D helicase GD442_RS25620 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_RS25630 ENOG4107RBB ABC transporter, permease GD442_RS25635 ENOG4105C19 ABC transporter GD442_RS25645 ENOG4105CXY transporter GD442_RS25660 ENOG4105BZU Histidine kinase GD442_RS25665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS25670 ENOG4105CMR udp-glucose 4-epimerase GD442_RS25680 ENOG4108KGH TRANSCRIPTIONal GD442_RS25685 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GD442_RS25700 ENOG4108PTS heparinase ii GD442_RS25705 ENOG4105CJR Integral membrane protein (MviN GD442_RS25710 ENOG4107T8Q Glycosyl transferase (Group 1 GD442_RS25730 ENOG4105D3Q Sugar transferase GD442_RS25735 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GD442_RS25740 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GD442_RS25745 ENOG4107YJ4 chain length determinant protein GD442_RS25750 ENOG4105HTX biosynthesis protein GD442_RS25755 ENOG4107YJ4 chain length determinant protein GD442_RS25770 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GD442_RS25780 ENOG4105FRN stage II sporulation protein GD442_RS25795 ENOG4105DY9 regulatoR GD442_RS25815 ENOG4106778 Protein of unknown function (DUF1146) GD442_RS25820 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GD442_RS25825 ENOG4105C8S subunit m GD442_RS25830 ENOG4105D65 subunit l GD442_RS25855 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GD442_RS25860 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GD442_RS25870 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GD442_RS25875 ENOG4105BZU Histidine kinase GD442_RS25925 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GD442_RS25930 ENOG41062M3 atp synthase GD442_RS25950 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GD442_RS25955 ENOG4108UIC UPF0340 protein GD442_RS25960 ENOG4108YZG isomerase GD442_RS25975 ENOG4108VGI doxx family GD442_RS25980 ENOG4107XC4 flavin reductase domain protein, FMN-binding GD442_RS25995 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GD442_RS26005 ENOG4108ZXQ stage ii sporulation protein r GD442_RS26010 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GD442_RS26015 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GD442_RS26020 ENOG4107104 thymidine kinase GD442_RS26030 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GD442_RS26035 ENOG4105CBT Fructose-1,6-bisphosphatase GD442_RS26040 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GD442_RS26060 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GD442_RS26075 ENOG4105C1G acyl-Coa dehydrogenase GD442_RS26080 ENOG4105C1G acyl-Coa dehydrogenase GD442_RS26085 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GD442_RS26095 ENOG4105DF6 Fe-S oxidoreductase GD442_RS26110 ENOG4105BZU Histidine kinase GD442_RS26125 ENOG4105D4Y metalloprotease GD442_RS26135 ENOG4105BZU Histidine kinase GD442_RS26140 ENOG4105KCT ABC transporter GD442_RS26145 ENOG4108M15 ABC transporter GD442_RS26150 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) GD442_RS26160 ENOG4105IIU Aminopeptidase GD442_RS26185 ENOG410684U Domain of unknown function (DUF1934) GD442_RS26205 ENOG4105CYW agmatinase GD442_RS26215 ENOG4105DXB Major Facilitator superfamily GD442_RS26220 ENOG4107SWG transcriptional regulator MERR family GD442_RS26225 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GD442_RS26230 ENOG4105BZ4 penicillin-binding protein GD442_RS26235 ENOG4108XFG YwhD family GD442_RS26240 ENOG4108Z4T Peptidase M50 GD442_RS26245 ENOG41069HH 4-oxalocrotonate tautomerase GD442_RS26250 ENOG4105DCI Phosphohydrolase GD442_RS26255 ENOG4108MES Periplasmic binding protein GD442_RS26260 ENOG4105E0A ABC, transporter GD442_RS26265 ENOG4105EHG Permease protein GD442_RS26270 ENOG4105DQ5 transport system permease protein GD442_RS26280 ENOG4108VCI transcription factor, rsfa family GD442_RS26285 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GD442_RS26290 ENOG4108IJ2 phosphate acetyltransferase GD442_RS26295 ENOG4107UEZ chlorite dismutase GD442_RS26305 ENOG4108VKI Cell wall hydrolase GD442_RS26325 ENOG4107SVH Potassium channel protein GD442_RS26335 ENOG410667J hydrolase GD442_RS26340 ENOG4105VCH membrane GD442_RS26350 ENOG4108TU7 Inherit from COG: (ABC) transporter GD442_RS26355 ENOG4105CJ1 ABC, transporter GD442_RS26360 ENOG41090WU lipolytic protein G-D-S-L family GD442_RS26375 ENOG4105D6E homoserine dehydrogenase GD442_RS26400 ENOG4108Y4K DNA-binding transcriptional activator GD442_RS26410 ENOG4105WH1 Two component transcriptional regulator luxr family GD442_RS26415 ENOG4105BZU Histidine kinase GD442_RS26420 ENOG4105DWF phosphomethylpyrimidine kinase GD442_RS26425 ENOG4105BZU Histidine kinase GD442_RS26430 ENOG4105VCD cytoplasmic protein GD442_RS26435 ENOG4105D22 carbon starvation protein GD442_RS26440 ENOG4105DY9 regulatoR GD442_RS26445 ENOG41079KZ Major Facilitator Superfamily GD442_RS26455 ENOG4105CG5 Glycosyl transferase (Group 1 GD442_RS26465 ENOG4105EN6 Membrane GD442_RS26470 ENOG4106YBV Methyl-accepting chemotaxis GD442_RS26480 ENOG4108S4H thioesterase Superfamily protein GD442_RS26485 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GD442_RS26500 ENOG4105K64 Glycosyl transferase, family 2 GD442_RS26510 ENOG4105EJV Membrane GD442_RS26515 ENOG4105CKK Glycosyl transferase, family 2 GD442_RS26520 ENOG4105C5H ABC transporter GD442_RS26525 ENOG41067SE Tetr family transcriptional regulator GD442_RS26535 ENOG4105E0X reductase GD442_RS26540 ENOG4106F5Q Membrane GD442_RS26555 ENOG4108NEV two component transcriptional regulator, LytTR family GD442_RS26560 ENOG4108HRK Histidine kinase GD442_RS26565 ENOG4107RGD Major Facilitator superfamily GD442_RS26580 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GD442_RS26590 ENOG4105IW1 AmiS UreI transporter GD442_RS26595 ENOG4105CMR udp-glucose 4-epimerase GD442_RS26600 ENOG4108UT2 hemolysin iii GD442_RS26610 ENOG4105C1J atp-dependent rna helicase GD442_RS26615 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) GD442_RS26620 ENOG4105DPN Oligoendopeptidase f GD442_RS26630 ENOG4105BZU Histidine kinase GD442_RS26635 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GD442_RS26645 ENOG4105C0H protease GD442_RS26650 ENOG4105Q2H domain protein GD442_RS26665 ENOG4105BZU Histidine kinase GD442_RS26670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_RS26695 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GD442_RS26700 ENOG4105CDU Replicative dna helicase GD442_RS26710 ENOG4105BZR domain protein GD442_RS26715 ENOG4108XMW Membrane GD442_RS26725 ENOG4108UUM single-stranded DNA-binding protein GD442_RS26735 ENOG4105C3G gtp-binding protein GD442_RS26740 ENOG4105VDK protein, conserved in bacteria GD442_RS26745 ENOG4105D8X mechanosensitive ion channel GD442_RS26750 ENOG4108ZDA Sporulation protein YyaC GD442_RS26755 ENOG4105FA0 parb-like partition protein GD442_RS26760 ENOG4107QJE Chromosome Partitioning Protein GD442_RS26775 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GD442_RS26780 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GD442_RS26790 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GD442_RS26895 ENOG4107JM4 Tetratricopeptide repeat GD442_RS26930 ENOG4107QJE Chromosome Partitioning Protein GD442_RS26950 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_RS26980 ENOG4105K4H Nlp p60 protein GD442_RS27100 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GD442_RS27285 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GD442_RS27300 ENOG4105K4H Nlp p60 protein GD442_RS27320 ENOG4108J59 Extracellular solute-binding protein, family 5 GD442_RS27345 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GD442_RS27455 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_RS27515 ENOG4105K4H Nlp p60 protein