locus-tag	class	description
GD442_RS00010	COG0592	DNA-directed DNA polymerase activity
GD442_RS00015	COG2501	S4 domain
GD442_RS00025	COG0187	DNA topoisomerase II activity
GD442_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GD442_RS00065	COG0517	IMP dehydrogenase activity
GD442_RS00065	COG0516	GMP reductase activity
GD442_RS00070	COG1686	Belongs to the peptidase S11 family
GD442_RS00100	COG1428	Deoxynucleoside kinase
GD442_RS00105	COG1428	Deoxynucleoside kinase
GD442_RS00110	COG1335	isochorismatase
GD442_RS00115	COG0590	tRNA wobble adenosine to inosine editing
GD442_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GD442_RS00180	COG1982	Orn Lys Arg decarboxylase major
GD442_RS00190	COG0470	DNA polymerase III
GD442_RS00195	COG1774	PSP1 C-terminal conserved region
GD442_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GD442_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GD442_RS00220	COG2002	toxin-antitoxin pair type II binding
GD442_RS00230	COG0084	hydrolase, TatD family'
GD442_RS00250	COG4466	Protein conserved in bacteria
GD442_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GD442_RS00270	COG0251	oxidation-reduction process
GD442_RS00285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GD442_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GD442_RS00305	COG2002	toxin-antitoxin pair type II binding
GD442_RS00310	COG2244	polysaccharide biosynthetic process
GD442_RS00315	COG3956	TIGRFAM MazG family protein
GD442_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GD442_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GD442_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GD442_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
GD442_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GD442_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GD442_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GD442_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GD442_RS00420	COG1396	sequence-specific DNA binding
GD442_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GD442_RS00515	COG3880	PFAM UvrB UvrC protein
GD442_RS00525	COG0542	response to heat
GD442_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GD442_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
GD442_RS00560	COG1045	serine acetyltransferase
GD442_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GD442_RS00580	COG3688	RNA-binding protein containing a PIN domain
GD442_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GD442_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GD442_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
GD442_RS00625	COG2813	Specifically methylates the guanine in position
GD442_RS00640	COG1358	cellular component organization or biogenesis
GD442_RS00745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GD442_RS00770	COG0201	protein transport
GD442_RS00780	COG0024	Methionine aminopeptidase
GD442_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GD442_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GD442_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
GD442_RS00855	COG0489	protein tyrosine kinase activity
GD442_RS00865	COG2194	sulfuric ester hydrolase activity
GD442_RS00870	COG0726	polysaccharide deacetylase
GD442_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GD442_RS00955	COG4856	YbbR-like protein
GD442_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS01010	COG2011	ABC-type metal ion transport system permease component
GD442_RS01015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GD442_RS01020	COG1464	Belongs to the NlpA lipoprotein family
GD442_RS01035	COG0277	FAD linked oxidase domain protein
GD442_RS01040	COG2271	Major facilitator Superfamily
GD442_RS01050	COG2814	Major facilitator Superfamily
GD442_RS01070	COG2207	Transcriptional regulator
GD442_RS01085	COG4166	transmembrane transport
GD442_RS01090	COG4166	transmembrane transport
GD442_RS01095	COG0656	L-ascorbic acid biosynthetic process
GD442_RS01115	COG4149	molybdate abc transporter
GD442_RS01120	COG0725	ABC transporter, periplasmic molybdate-binding protein
GD442_RS01125	COG1910	domain protein
GD442_RS01140	COG0697	spore germination
GD442_RS01155	COG0204	Acyl-transferase
GD442_RS01165	COG1609	Transcriptional regulator
GD442_RS01175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS01190	COG5298	Protein conserved in bacteria
GD442_RS01210	COG0488	(ABC) transporter
GD442_RS01220	COG0747	negative chemotaxis
GD442_RS01225	COG0601	transmembrane transport
GD442_RS01235	COG0444	Belongs to the ABC transporter superfamily
GD442_RS01240	COG4608	Belongs to the ABC transporter superfamily
GD442_RS01245	COG0561	phosphatase activity
GD442_RS01270	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GD442_RS01275	COG0179	Fumarylacetoacetate (FAA) hydrolase
GD442_RS01285	COG0531	amino acid
GD442_RS01290	COG2814	Major facilitator Superfamily
GD442_RS01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GD442_RS01310	COG4294	response to UV
GD442_RS01315	COG0705	Rhomboid family
GD442_RS01325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GD442_RS01330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GD442_RS01335	COG0864	Transcriptional regulator
GD442_RS01340	COG2337	Toxic component of a toxin-antitoxin (TA) module
GD442_RS01345	COG2183	response to ionizing radiation
GD442_RS01445	COG0802	atpase or kinase
GD442_RS01450	COG1214	PFAM Peptidase M22, glycoprotease
GD442_RS01455	COG0456	acetyltransferase
GD442_RS01465	COG0488	(ABC) transporter
GD442_RS01480	COG1266	CAAX protease self-immunity
GD442_RS01500	COG2252	PERMEase
GD442_RS01510	COG5002	protein histidine kinase activity
GD442_RS01535	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GD442_RS01575	COG2205	protein histidine kinase activity
GD442_RS01580	COG0745	RESPONSE REGULATOR receiver
GD442_RS01610	COG2226	methyltransferase
GD442_RS01620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GD442_RS01630	COG1215	transferase activity, transferring glycosyl groups
GD442_RS01650	COG0697	spore germination
GD442_RS01680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GD442_RS01685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GD442_RS01690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GD442_RS01700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GD442_RS01715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GD442_RS01725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GD442_RS01735	COG0151	Belongs to the GarS family
GD442_RS01760	COG0210	DNA helicase
GD442_RS01770	COG4851	CamS sex pheromone cAM373 precursor
GD442_RS01785	COG1335	isochorismatase
GD442_RS01795	COG2011	ABC-type metal ion transport system permease component
GD442_RS01800	COG1464	Belongs to the NlpA lipoprotein family
GD442_RS01815	COG0003	Pfam Anion-transporting ATPase
GD442_RS01820	COG1846	Transcriptional regulator
GD442_RS01825	COG4682	membrane
GD442_RS01845	COG1597	lipid kinase activity
GD442_RS01855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GD442_RS01865	COG1012	belongs to the aldehyde dehydrogenase family
GD442_RS01870	COG2076	Multidrug Resistance protein
GD442_RS01880	COG2309	aminopeptidase activity
GD442_RS01895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GD442_RS01905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GD442_RS01910	COG4807	Protein conserved in bacteria
GD442_RS01940	COG1473	amidohydrolase
GD442_RS01960	COG0450	alkyl hydroperoxide reductase
GD442_RS01965	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GD442_RS01975	COG0235	Class ii aldolase
GD442_RS01980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS01985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS01990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GD442_RS02005	COG0166	Belongs to the GPI family
GD442_RS02030	COG5002	protein histidine kinase activity
GD442_RS02050	COG3541	Predicted nucleotidyltransferase
GD442_RS02060	COG0723	plastoquinol--plastocyanin reductase activity
GD442_RS02060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GD442_RS02070	COG0765	amino acid transport
GD442_RS02075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD442_RS02080	COG1126	abc transporter atp-binding protein
GD442_RS02085	COG0840	transmembrane signaling receptor activity
GD442_RS02110	COG0549	Belongs to the carbamate kinase family
GD442_RS02115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GD442_RS02125	COG0277	FAD linked oxidase domain protein
GD442_RS02130	COG0366	Alpha amylase catalytic
GD442_RS02135	COG1263	PTS System
GD442_RS02135	COG2190	(PTS) system
GD442_RS02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GD442_RS02165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GD442_RS02185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GD442_RS02190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GD442_RS02195	COG1116	anion transmembrane transporter activity
GD442_RS02200	COG0488	(ABC) transporter
GD442_RS02245	COG2270	Major facilitator Superfamily
GD442_RS02275	COG2310	stress, protein
GD442_RS02280	COG2310	stress, protein
GD442_RS02285	COG2310	stress, protein
GD442_RS02290	COG0861	Integral membrane protein TerC family
GD442_RS02300	COG3853	Toxic anion resistance protein (TelA)
GD442_RS02315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GD442_RS02325	COG1295	ribonuclease BN
GD442_RS02330	COG2217	Heavy metal translocating P-type atpase
GD442_RS02335	COG0697	spore germination
GD442_RS02345	COG0681	Belongs to the peptidase S26 family
GD442_RS02355	COG0586	Pfam SNARE associated Golgi protein
GD442_RS02370	COG3871	stress protein (general stress protein 26)
GD442_RS02375	COG0387	Pfam Sodium calcium exchanger
GD442_RS02385	COG0535	radical SAM domain protein
GD442_RS02405	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GD442_RS02410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GD442_RS02425	COG3829	transcription factor binding
GD442_RS02435	COG0833	amino acid
GD442_RS02440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GD442_RS02465	COG1263	PTS System
GD442_RS02465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GD442_RS02470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GD442_RS02485	COG0463	Glycosyl transferase, family 2
GD442_RS02495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GD442_RS02495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GD442_RS02515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GD442_RS02535	COG1228	amidohydrolase
GD442_RS02540	COG1090	epimerase
GD442_RS02570	COG1988	membrane-bound metal-dependent
GD442_RS02575	COG1194	a g-specific adenine glycosylase
GD442_RS02600	COG1132	(ABC) transporter
GD442_RS02605	COG4129	membrane
GD442_RS02610	COG0067	glutamate synthase
GD442_RS02610	COG0070	glutamate synthase
GD442_RS02610	COG0069	glutamate synthase activity
GD442_RS02620	COG4555	ABC transporter
GD442_RS02640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GD442_RS02645	COG0735	belongs to the Fur family
GD442_RS02765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GD442_RS02790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GD442_RS02800	COG2766	serine protein kinase
GD442_RS02820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GD442_RS02830	COG1585	Membrane protein implicated in regulation of membrane protease activity
GD442_RS02835	COG2268	Band 7 protein
GD442_RS02845	COG3290	protein histidine kinase activity
GD442_RS02850	COG4565	transcriptional regulatory protein
GD442_RS02855	COG2851	Citrate transporter
GD442_RS02880	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GD442_RS02885	COG3842	ATPase activity
GD442_RS02890	COG1175	transmembrane transport
GD442_RS02895	COG0395	ABC-type sugar transport system, permease component
GD442_RS02905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GD442_RS02910	COG0745	RESPONSE REGULATOR receiver
GD442_RS02915	COG5002	protein histidine kinase activity
GD442_RS02925	COG4990	cell redox homeostasis
GD442_RS02935	COG3290	protein histidine kinase activity
GD442_RS02940	COG4565	transcriptional regulatory protein
GD442_RS02945	COG3493	citrate carrier protein
GD442_RS02950	COG0281	malic enzyme
GD442_RS02960	COG0697	spore germination
GD442_RS02965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD442_RS02975	COG5002	protein histidine kinase activity
GD442_RS02990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GD442_RS02995	COG3383	formate dehydrogenase (NAD+) activity
GD442_RS03000	COG2427	Protein of unknown function (DUF1641)
GD442_RS03015	COG0531	amino acid
GD442_RS03025	COG0640	Transcriptional regulator
GD442_RS03030	COG2217	Heavy metal translocating P-type atpase
GD442_RS03035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GD442_RS03050	COG3227	Zinc metalloprotease (Elastase)
GD442_RS03070	COG2720	vancomycin resistance protein
GD442_RS03075	COG1316	TRANSCRIPTIONal
GD442_RS03080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GD442_RS03085	COG0346	lactoylglutathione lyase activity
GD442_RS03090	COG1253	flavin adenine dinucleotide binding
GD442_RS03095	COG1027	Aspartate ammonia-lyase
GD442_RS03100	COG1620	l-lactate permease
GD442_RS03115	COG3104	oligopeptide transport
GD442_RS03120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GD442_RS03125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS03130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS03150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GD442_RS03160	COG4548	von Willebrand factor, type A
GD442_RS03165	COG0714	Associated with various cellular activities
GD442_RS03185	COG0531	amino acid
GD442_RS03190	COG2188	Transcriptional regulator
GD442_RS03195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GD442_RS03195	COG1263	PTS System
GD442_RS03200	COG0366	Alpha amylase catalytic
GD442_RS03215	COG0697	spore germination
GD442_RS03225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GD442_RS03230	COG1115	amino acid carrier protein
GD442_RS03235	COG1126	abc transporter atp-binding protein
GD442_RS03240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD442_RS03245	COG0765	amino acid transport
GD442_RS03250	COG0765	amino acid transport
GD442_RS03255	COG0833	amino acid
GD442_RS03280	COG2378	regulation of single-species biofilm formation
GD442_RS03285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GD442_RS03290	COG5002	protein histidine kinase activity
GD442_RS03305	COG0659	secondary active sulfate transmembrane transporter activity
GD442_RS03320	COG2271	Major facilitator Superfamily
GD442_RS03325	COG1846	Transcriptional regulator
GD442_RS03330	COG0477	Major facilitator Superfamily
GD442_RS03335	COG1609	Transcriptional regulator
GD442_RS03340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GD442_RS03355	COG1172	Belongs to the binding-protein-dependent transport system permease family
GD442_RS03360	COG1879	ABC-type sugar transport system periplasmic component
GD442_RS03380	COG1063	alcohol dehydrogenase
GD442_RS03430	COG0840	transmembrane signaling receptor activity
GD442_RS03435	COG3583	domain protein
GD442_RS03435	COG3584	3D domain protein
GD442_RS03440	COG1476	TRANSCRIPTIONal
GD442_RS03460	COG3104	oligopeptide transport
GD442_RS03465	COG1114	Component of the transport system for branched-chain amino acids
GD442_RS03480	COG1113	amino acid transport
GD442_RS03485	COG2252	PERMEase
GD442_RS03510	COG2153	protein acetylation
GD442_RS03520	COG0475	glutathione-regulated potassium exporter activity
GD442_RS03520	COG0569	domain protein
GD442_RS03535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GD442_RS03545	COG0833	amino acid
GD442_RS03550	COG4990	cell redox homeostasis
GD442_RS03565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GD442_RS03570	COG0697	spore germination
GD442_RS03575	COG0531	amino acid
GD442_RS03585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GD442_RS03590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GD442_RS03595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GD442_RS03595	COG1918	ferrous iron import across plasma membrane
GD442_RS03600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GD442_RS03605	COG0573	inorganic phosphate transmembrane transporter activity
GD442_RS03610	COG0581	inorganic phosphate transmembrane transporter activity
GD442_RS03620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GD442_RS03740	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GD442_RS03760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GD442_RS03765	COG1116	anion transmembrane transporter activity
GD442_RS03770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GD442_RS03775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GD442_RS03780	COG0352	thiamine-phosphate diphosphorylase activity
GD442_RS03785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GD442_RS03790	COG2104	thiamine diphosphate biosynthetic process
GD442_RS03800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GD442_RS03805	COG0351	phosphomethylpyrimidine kinase
GD442_RS03845	COG2205	protein histidine kinase activity
GD442_RS03850	COG2814	Major facilitator Superfamily
GD442_RS03855	COG1846	Transcriptional regulator
GD442_RS03880	COG1136	(ABC) transporter
GD442_RS03895	COG1172	Belongs to the binding-protein-dependent transport system permease family
GD442_RS03900	COG1129	ABC transporter
GD442_RS03910	COG2252	PERMEase
GD442_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS03930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GD442_RS03935	COG1621	beta-fructofuranosidase activity
GD442_RS03940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GD442_RS03940	COG1263	PTS System
GD442_RS03945	COG1609	Transcriptional regulator
GD442_RS03995	COG0778	Nitroreductase
GD442_RS04000	COG2719	SpoVR family
GD442_RS04010	COG1414	Transcriptional regulator
GD442_RS04025	COG0446	pyridine nucleotide-disulphide oxidoreductase
GD442_RS04030	COG1937	Protein conserved in bacteria
GD442_RS04035	COG0425	Belongs to the sulfur carrier protein TusA family
GD442_RS04035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GD442_RS04040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GD442_RS04040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS04045	COG0425	Belongs to the sulfur carrier protein TusA family
GD442_RS04050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GD442_RS04050	COG0425	Belongs to the sulfur carrier protein TusA family
GD442_RS04055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GD442_RS04060	COG2210	Belongs to the sulfur carrier protein TusA family
GD442_RS04065	COG0730	response to heat
GD442_RS04075	COG1316	TRANSCRIPTIONal
GD442_RS04080	COG0604	alcohol dehydrogenase
GD442_RS04085	COG1283	sodium-dependent phosphate transmembrane transporter activity
GD442_RS04100	COG3711	transcriptional antiterminator
GD442_RS04100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GD442_RS04105	COG1447	Phosphotransferase system cellobiose-specific component IIA
GD442_RS04110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GD442_RS04135	COG3584	3D domain protein
GD442_RS04135	COG1388	LysM domain
GD442_RS04140	COG0577	efflux transmembrane transporter activity
GD442_RS04145	COG1136	(ABC) transporter
GD442_RS04155	COG5522	Integral membrane protein (intg_mem_TP0381)
GD442_RS04170	COG1114	Component of the transport system for branched-chain amino acids
GD442_RS04175	COG3546	catalase activity
GD442_RS04210	COG0586	Pfam SNARE associated Golgi protein
GD442_RS04240	COG0531	amino acid
GD442_RS04245	COG0475	glutathione-regulated potassium exporter activity
GD442_RS04255	COG1737	Transcriptional regulator
GD442_RS04265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GD442_RS04265	COG1263	PTS System
GD442_RS04275	COG2259	Doxx family
GD442_RS04295	COG1522	sequence-specific DNA binding
GD442_RS04300	COG0165	Argininosuccinate lyase
GD442_RS04300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GD442_RS04305	COG0300	oxidoreductase activity
GD442_RS04315	COG2076	Multidrug Resistance protein
GD442_RS04325	COG1309	transcriptional regulator
GD442_RS04330	COG2814	Major facilitator Superfamily
GD442_RS04335	COG1733	regulation of RNA biosynthetic process
GD442_RS04375	COG0693	protein deglycase activity
GD442_RS04380	COG0693	protein deglycase activity
GD442_RS04380	COG0753	catalase activity
GD442_RS04390	COG0531	amino acid
GD442_RS04395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GD442_RS04405	COG1012	belongs to the aldehyde dehydrogenase family
GD442_RS04410	COG1132	(ABC) transporter
GD442_RS04415	COG1132	(ABC) transporter
GD442_RS04420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD442_RS04425	COG0765	amino acid transport
GD442_RS04430	COG1126	abc transporter atp-binding protein
GD442_RS04445	COG0189	ligase activity
GD442_RS04475	COG0028	Belongs to the TPP enzyme family
GD442_RS04480	COG3527	Alpha-acetolactate decarboxylase
GD442_RS04490	COG0561	phosphatase activity
GD442_RS04500	COG5632	N-Acetylmuramoyl-L-alanine amidase
GD442_RS04500	COG3409	Peptidoglycan-binding domain 1 protein
GD442_RS04505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GD442_RS04510	COG0318	PFAM AMP-dependent synthetase and ligase
GD442_RS04525	COG0659	secondary active sulfate transmembrane transporter activity
GD442_RS04530	COG2244	polysaccharide biosynthetic process
GD442_RS04550	COG1024	Enoyl-CoA hydratase
GD442_RS04570	COG1363	Peptidase, m42
GD442_RS04605	COG0601	transmembrane transport
GD442_RS04610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GD442_RS04615	COG0444	Belongs to the ABC transporter superfamily
GD442_RS04620	COG4608	Belongs to the ABC transporter superfamily
GD442_RS04645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS04725	COG0477	Major facilitator Superfamily
GD442_RS04730	COG3290	protein histidine kinase activity
GD442_RS04735	COG4565	transcriptional regulatory protein
GD442_RS04740	COG3181	Tripartite tricarboxylate transporter family receptor
GD442_RS04780	COG0305	Participates in initiation and elongation during chromosome replication
GD442_RS04800	COG0477	Major facilitator Superfamily
GD442_RS04815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS04835	COG1073	alpha beta
GD442_RS04875	COG1183	phosphatidylcholine synthase activity
GD442_RS04895	COG2376	Dihydroxyacetone kinase
GD442_RS04905	COG2376	Dihydroxyacetone kinase
GD442_RS04935	COG1388	LysM domain
GD442_RS04935	COG3584	3D domain protein
GD442_RS04940	COG1388	LysM domain
GD442_RS04940	COG0791	NLP P60 protein
GD442_RS04945	COG2373	Large extracellular alpha-helical protein
GD442_RS04965	COG0596	Alpha beta hydrolase
GD442_RS05015	COG1191	sigma factor activity
GD442_RS05025	COG2208	phosphoserine phosphatase activity
GD442_RS05030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GD442_RS05035	COG5002	protein histidine kinase activity
GD442_RS05035	COG2205	protein histidine kinase activity
GD442_RS05035	COG0784	Response regulator, receiver
GD442_RS05055	COG0393	Putative heavy-metal-binding
GD442_RS05070	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GD442_RS05090	COG0420	3'-5' exonuclease activity
GD442_RS05095	COG4717	serine-type aminopeptidase activity
GD442_RS05105	COG0346	lactoylglutathione lyase activity
GD442_RS05110	COG0346	lactoylglutathione lyase activity
GD442_RS05115	COG0457	Tetratricopeptide repeat
GD442_RS05125	COG2267	carboxylic ester hydrolase activity
GD442_RS05145	COG2140	Oxalate decarboxylase
GD442_RS05150	COG3620	sequence-specific DNA binding
GD442_RS05155	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GD442_RS05160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GD442_RS05170	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GD442_RS05175	COG1695	Transcriptional regulator
GD442_RS05190	COG3973	AAA domain
GD442_RS05220	COG4980	gas vesicle protein
GD442_RS05225	COG0537	adenosine 5'-monophosphoramidase activity
GD442_RS05230	COG1131	(ABC) transporter
GD442_RS05235	COG4473	ABC transporter
GD442_RS05255	COG3402	PFAM membrane-flanked domain
GD442_RS05260	COG3428	Bacterial PH domain
GD442_RS05295	COG0697	spore germination
GD442_RS05300	COG3402	PFAM membrane-flanked domain
GD442_RS05305	COG3428	Bacterial PH domain
GD442_RS05310	COG2329	Antibiotic biosynthesis monooxygenase
GD442_RS05315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GD442_RS05365	COG1309	transcriptional regulator
GD442_RS05370	COG1511	domain protein
GD442_RS05370	COG1511	domain protein
GD442_RS05385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS05390	COG1609	Transcriptional regulator
GD442_RS05400	COG1234	tRNA 3'-trailer cleavage
GD442_RS05405	COG0095	Lipoate-protein ligase
GD442_RS05415	COG0318	PFAM AMP-dependent synthetase and ligase
GD442_RS05425	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GD442_RS05435	COG4208	sulfate ABC transporter
GD442_RS05500	COG1408	metallophosphoesterase
GD442_RS05505	COG1078	dGTPase activity
GD442_RS05515	COG1595	DNA-templated transcription, initiation
GD442_RS05520	COG3708	Transcriptional regulator
GD442_RS05520	COG2207	Transcriptional regulator
GD442_RS05525	COG2205	protein histidine kinase activity
GD442_RS05530	COG0745	RESPONSE REGULATOR receiver
GD442_RS05550	COG0501	Belongs to the peptidase M48B family
GD442_RS05555	COG0840	transmembrane signaling receptor activity
GD442_RS05560	COG3693	PFAM glycoside hydrolase, family 10
GD442_RS05570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GD442_RS05575	COG2224	Isocitrate lyase
GD442_RS05590	COG1278	Cold shock
GD442_RS05610	COG0398	Pfam SNARE associated Golgi protein
GD442_RS05670	COG0179	Fumarylacetoacetate (FAA) hydrolase
GD442_RS05695	COG0367	asparagine synthase
GD442_RS05705	COG0753	catalase activity
GD442_RS05710	COG0004	ammonium transporteR
GD442_RS05730	COG2996	Protein conserved in bacteria
GD442_RS05745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS05760	COG0561	phosphatase activity
GD442_RS05780	COG2267	carboxylic ester hydrolase activity
GD442_RS05800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GD442_RS05805	COG5504	Zn-dependent protease
GD442_RS05815	COG0180	Tryptophanyl-tRNA synthetase
GD442_RS05825	COG4166	transmembrane transport
GD442_RS05830	COG0601	transmembrane transport
GD442_RS05835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GD442_RS05840	COG0444	Belongs to the ABC transporter superfamily
GD442_RS05845	COG4608	Belongs to the ABC transporter superfamily
GD442_RS05850	COG0534	Mate efflux family protein
GD442_RS05855	COG4166	transmembrane transport
GD442_RS05865	COG1393	Belongs to the ArsC family
GD442_RS05870	COG0861	Integral membrane protein TerC family
GD442_RS05890	COG1164	Oligoendopeptidase f
GD442_RS05900	COG2346	COG2346, Truncated hemoglobins
GD442_RS05905	COG4116	CYTH
GD442_RS05915	COG2357	RelA SpoT domain protein
GD442_RS05925	COG0564	pseudouridine synthase activity
GD442_RS05940	COG0772	Belongs to the SEDS family
GD442_RS05945	COG1216	Glycosyl transferase, family 2
GD442_RS05965	COG0457	Tetratricopeptide repeat
GD442_RS05965	COG0463	Glycosyl transferase, family 2
GD442_RS05985	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GD442_RS06000	COG1091	dTDP-4-dehydrorhamnose reductase activity
GD442_RS06045	COG2153	protein acetylation
GD442_RS06055	COG2382	esterase
GD442_RS06075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GD442_RS06085	COG0512	Glutamine amidotransferase of anthranilate synthase
GD442_RS06085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GD442_RS06120	COG1620	l-lactate permease
GD442_RS06125	COG5634	Uncharacterized conserved protein (DUF2278)
GD442_RS06175	COG0508	dehydrogenase complex catalyzes the overall conversion of
GD442_RS06185	COG1476	TRANSCRIPTIONal
GD442_RS06245	COG1686	Belongs to the peptidase S11 family
GD442_RS06250	COG0681	Belongs to the peptidase S26 family
GD442_RS06285	COG1012	belongs to the aldehyde dehydrogenase family
GD442_RS06295	COG1176	ABC-type spermidine putrescine transport system, permease component I
GD442_RS06300	COG1177	transmembrane transport
GD442_RS06305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GD442_RS06315	COG2409	Drug exporters of the RND superfamily
GD442_RS06325	COG0564	pseudouridine synthase activity
GD442_RS06335	COG2340	Cysteine-rich secretory protein family
GD442_RS06340	COG0247	lactate metabolic process
GD442_RS06345	COG0277	FAD linked oxidase domain protein
GD442_RS06350	COG3835	regulator
GD442_RS06360	COG0745	RESPONSE REGULATOR receiver
GD442_RS06365	COG5002	protein histidine kinase activity
GD442_RS06370	COG2186	Transcriptional regulator
GD442_RS06390	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GD442_RS06400	COG2116	formate transmembrane transporter activity
GD442_RS06405	COG0861	Integral membrane protein TerC family
GD442_RS06410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GD442_RS06420	COG2030	dehydratase
GD442_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS06445	COG3243	poly(R)-hydroxyalkanoic acid synthase
GD442_RS06455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GD442_RS06465	COG1840	ABC-type Fe3 transport system, periplasmic component
GD442_RS06470	COG3842	ATPase activity
GD442_RS06495	COG1349	DNA-binding transcription factor activity
GD442_RS06505	COG0235	Class ii aldolase
GD442_RS06515	COG2861	carbohydrate metabolic process
GD442_RS06525	COG3852	Histidine kinase
GD442_RS06530	COG1846	Transcriptional regulator
GD442_RS06540	COG2318	DinB family
GD442_RS06545	COG5002	protein histidine kinase activity
GD442_RS06555	COG0720	synthase
GD442_RS06570	COG4873	Protein conserved in bacteria
GD442_RS06595	COG1780	Probably involved in ribonucleotide reductase function
GD442_RS06615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GD442_RS06620	COG1725	Transcriptional regulator
GD442_RS06625	COG1131	(ABC) transporter
GD442_RS06635	COG1131	(ABC) transporter
GD442_RS06655	COG1522	sequence-specific DNA binding
GD442_RS06665	COG1335	isochorismatase
GD442_RS06675	COG1619	proteins homologs of microcin C7 resistance protein MccF
GD442_RS06680	COG2070	2-Nitropropane dioxygenase
GD442_RS06685	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GD442_RS06695	COG1696	Membrane protein involved in D-alanine export
GD442_RS06715	COG0716	FMN binding
GD442_RS06725	COG3173	Aminoglycoside phosphotransferase
GD442_RS06760	COG1846	Transcriptional regulator
GD442_RS06770	COG1301	dicarboxylic acid transport
GD442_RS06775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GD442_RS06780	COG4709	membrane
GD442_RS06785	COG3874	Sporulation protein YtfJ
GD442_RS06805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GD442_RS06810	COG0028	Belongs to the TPP enzyme family
GD442_RS06815	COG0440	acetolactate synthase activity
GD442_RS06890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GD442_RS06905	COG1183	phosphatidylcholine synthase activity
GD442_RS06910	COG1368	sulfuric ester hydrolase activity
GD442_RS06920	COG0019	diaminopimelate decarboxylase activity
GD442_RS06940	COG0529	Catalyzes the synthesis of activated sulfate
GD442_RS06945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GD442_RS06965	COG1648	precorrin-2 dehydrogenase activity
GD442_RS06970	COG0733	neurotransmitter:sodium symporter activity
GD442_RS06990	COG1757	Na H antiporter
GD442_RS07005	COG4758	membrane
GD442_RS07010	COG4585	Histidine kinase
GD442_RS07015	COG2197	response regulator
GD442_RS07025	COG1114	Component of the transport system for branched-chain amino acids
GD442_RS07075	COG0730	response to heat
GD442_RS07080	COG0306	phosphate transporter
GD442_RS07085	COG1392	Phosphate transport regulator
GD442_RS07090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GD442_RS07105	COG3852	Histidine kinase
GD442_RS07110	COG1801	Protein of unknown function DUF72
GD442_RS07120	COG0582	viral genome integration into host DNA
GD442_RS07125	COG5002	protein histidine kinase activity
GD442_RS07140	COG0392	lysyltransferase activity
GD442_RS07140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GD442_RS07155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GD442_RS07160	COG1686	Belongs to the peptidase S11 family
GD442_RS07165	COG2715	membrane protein required for spore maturation
GD442_RS07170	COG0700	Nucleoside recognition
GD442_RS07175	COG1187	pseudouridine synthase activity
GD442_RS07185	COG1333	cytochrome c biogenesis protein
GD442_RS07190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GD442_RS07195	COG0745	RESPONSE REGULATOR receiver
GD442_RS07200	COG5002	protein histidine kinase activity
GD442_RS07205	COG2096	Adenosyltransferase
GD442_RS07220	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GD442_RS07225	COG1141	Ferredoxin
GD442_RS07235	COG0514	ATP-dependent DNA helicase (RecQ)
GD442_RS07240	COG1266	CAAX protease self-immunity
GD442_RS07250	COG1408	metallophosphoesterase
GD442_RS07255	COG0789	Transcriptional regulator
GD442_RS07265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GD442_RS07285	COG0492	ferredoxin-NADP+ reductase activity
GD442_RS07290	COG0252	asparaginase activity
GD442_RS07360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GD442_RS07375	COG0142	geranyltranstransferase activity
GD442_RS07385	COG0142	geranyltranstransferase activity
GD442_RS07410	COG0457	Tetratricopeptide repeat
GD442_RS07430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GD442_RS07435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GD442_RS07435	COG2010	Cytochrome c
GD442_RS07440	COG4347	Protein of unknown function (DUF1405)
GD442_RS07455	COG2738	Putative neutral zinc metallopeptidase
GD442_RS07465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS07470	COG1694	Mazg nucleotide pyrophosphohydrolase
GD442_RS07490	COG0438	transferase activity, transferring glycosyl groups
GD442_RS07525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GD442_RS07525	COG1199	ATP-dependent helicase activity
GD442_RS07545	COG3935	DnaD domain protein
GD442_RS07550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GD442_RS07560	COG4499	WXG100 protein secretion system (Wss), protein YukC
GD442_RS07560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GD442_RS07615	COG0116	Belongs to the methyltransferase superfamily
GD442_RS07625	COG1199	ATP-dependent helicase activity
GD442_RS07630	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GD442_RS07640	COG0024	Methionine aminopeptidase
GD442_RS07650	COG2233	PERMEase
GD442_RS07655	COG2311	Membrane
GD442_RS07665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GD442_RS07675	COG0456	acetyltransferase
GD442_RS07725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GD442_RS07740	COG3944	biosynthesis protein
GD442_RS07750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GD442_RS07765	COG1215	transferase activity, transferring glycosyl groups
GD442_RS07770	COG0438	transferase activity, transferring glycosyl groups
GD442_RS07785	COG0454	-acetyltransferase
GD442_RS07805	COG0328	RNA-DNA hybrid ribonuclease activity
GD442_RS07840	COG3403	YqcI/YcgG family
GD442_RS07845	COG1280	lysine exporter protein (LysE YggA)
GD442_RS07865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GD442_RS07870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GD442_RS07880	COG0475	glutathione-regulated potassium exporter activity
GD442_RS07885	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GD442_RS07890	COG0789	Transcriptional regulator
GD442_RS07890	COG4978	Transcriptional regulator
GD442_RS07900	COG2323	membrane
GD442_RS07905	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GD442_RS07950	COG1923	regulation of RNA biosynthetic process
GD442_RS07960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GD442_RS07965	COG1360	Flagellar Motor Protein
GD442_RS07970	COG2201	protein-glutamate methylesterase activity
GD442_RS07975	COG2198	Histidine kinase
GD442_RS07975	COG0643	Histidine kinase
GD442_RS07980	COG1776	CheC inhibitor of MCP methylation
GD442_RS07980	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GD442_RS07995	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GD442_RS08015	COG1256	bacterial-type flagellum assembly
GD442_RS08020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GD442_RS08025	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GD442_RS08040	COG1815	bacterial-type flagellum-dependent cell motility
GD442_RS08045	COG1558	bacterial-type flagellum-dependent cell motility
GD442_RS08050	COG1677	Flagellar hook-basal body complex protein FliE
GD442_RS08055	COG1766	The M ring may be actively involved in energy transduction
GD442_RS08060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GD442_RS08070	COG1157	protein secretion by the type III secretion system
GD442_RS08090	COG1749	Flagellar hook protein flgE
GD442_RS08105	COG0784	Response regulator, receiver
GD442_RS08105	COG0835	chemotaxis
GD442_RS08115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GD442_RS08120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GD442_RS08125	COG0741	lytic transglycosylase activity
GD442_RS08135	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GD442_RS08140	COG1776	CheC inhibitor of MCP methylation
GD442_RS08140	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GD442_RS08150	COG1338	Plays a role in the flagellum-specific transport system
GD442_RS08155	COG1987	bacterial-type flagellum assembly
GD442_RS08165	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GD442_RS08170	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GD442_RS08175	COG1419	protein localization to endoplasmic reticulum
GD442_RS08180	COG4786	Flagellar basal body rod
GD442_RS08185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GD442_RS08220	COG2329	Antibiotic biosynthesis monooxygenase
GD442_RS08260	COG1177	transmembrane transport
GD442_RS08265	COG1234	tRNA 3'-trailer cleavage
GD442_RS08295	COG0406	alpha-ribazole phosphatase activity
GD442_RS08325	COG0367	asparagine synthase
GD442_RS08355	COG1802	Transcriptional regulator
GD442_RS08360	COG0697	spore germination
GD442_RS08370	COG0523	cobalamin synthesis protein
GD442_RS08375	COG0701	Predicted permease
GD442_RS08390	COG1757	Na H antiporter
GD442_RS08395	COG0789	Transcriptional regulator
GD442_RS08420	COG0534	Mate efflux family protein
GD442_RS08425	COG3340	Belongs to the peptidase S51 family
GD442_RS08445	COG0785	Cytochrome C biogenesis protein
GD442_RS08450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GD442_RS08460	COG0457	Tetratricopeptide repeat
GD442_RS08480	COG2733	membrane
GD442_RS08515	COG1131	(ABC) transporter
GD442_RS08530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GD442_RS08535	COG0528	UMP kinase activity
GD442_RS08545	COG1027	Aspartate ammonia-lyase
GD442_RS08550	COG0281	malic enzyme
GD442_RS08555	COG4191	Histidine kinase
GD442_RS08560	COG0784	Response regulator, receiver
GD442_RS08565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GD442_RS08620	COG1695	Transcriptional regulator
GD442_RS08630	COG0477	Major facilitator Superfamily
GD442_RS08640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GD442_RS08645	COG2223	nitrite transmembrane transporter activity
GD442_RS08650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GD442_RS08670	COG0733	neurotransmitter:sodium symporter activity
GD442_RS08680	COG5566	PFAM Mor transcription activator
GD442_RS08685	COG2323	membrane
GD442_RS08705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GD442_RS08715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GD442_RS08720	COG0028	Belongs to the TPP enzyme family
GD442_RS08740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GD442_RS08765	COG2814	Major facilitator Superfamily
GD442_RS08770	COG3384	dioxygenase
GD442_RS08780	COG3279	Response regulator of the LytR AlgR family
GD442_RS08785	COG0427	acetyl-CoA hydrolase
GD442_RS08805	COG4166	transmembrane transport
GD442_RS08810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS08815	COG1914	H( )-stimulated, divalent metal cation uptake system
GD442_RS08830	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GD442_RS08835	COG0531	amino acid
GD442_RS08865	COG2309	aminopeptidase activity
GD442_RS08880	COG0456	acetyltransferase
GD442_RS08895	COG1309	transcriptional regulator
GD442_RS08900	COG2390	Transcriptional regulator
GD442_RS08910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GD442_RS08915	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GD442_RS08925	COG4846	Membrane protein involved in cytochrome C biogenesis
GD442_RS08945	COG0583	DNA-binding transcription factor activity
GD442_RS08960	COG0006	proline dipeptidase activity
GD442_RS08970	COG2132	Multicopper oxidase
GD442_RS09000	COG1114	Component of the transport system for branched-chain amino acids
GD442_RS09010	COG1276	copper resistance
GD442_RS09010	COG2372	response to copper ion
GD442_RS09015	COG4549	nuclear export factor GLE1
GD442_RS09020	COG0697	spore germination
GD442_RS09025	COG0583	DNA-binding transcription factor activity
GD442_RS09030	COG1959	2 iron, 2 sulfur cluster binding
GD442_RS09035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GD442_RS09040	COG0778	Nitroreductase
GD442_RS09050	COG0628	permease
GD442_RS09060	COG1231	oxidoreductase activity
GD442_RS09065	COG0523	cobalamin synthesis protein
GD442_RS09075	COG0411	ABC transporter
GD442_RS09085	COG0559	Belongs to the binding-protein-dependent transport system permease family
GD442_RS09095	COG0583	DNA-binding transcription factor activity
GD442_RS09105	COG1942	4-Oxalocrotonate Tautomerase
GD442_RS09125	COG1271	oxidase subunit
GD442_RS09130	COG1294	oxidase, subunit
GD442_RS09135	COG4988	ABC transporter
GD442_RS09140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GD442_RS09150	COG1216	Glycosyl transferase, family 2
GD442_RS09190	COG1686	Belongs to the peptidase S11 family
GD442_RS09205	COG0791	NLP P60 protein
GD442_RS09205	COG1388	LysM domain
GD442_RS09215	COG1132	(ABC) transporter
GD442_RS09220	COG0745	RESPONSE REGULATOR receiver
GD442_RS09225	COG5002	protein histidine kinase activity
GD442_RS09230	COG0300	oxidoreductase activity
GD442_RS09240	COG0726	polysaccharide deacetylase
GD442_RS09260	COG0460	homoserine dehydrogenase
GD442_RS09285	COG1316	TRANSCRIPTIONal
GD442_RS09295	COG0745	RESPONSE REGULATOR receiver
GD442_RS09300	COG5002	protein histidine kinase activity
GD442_RS09305	COG0726	polysaccharide deacetylase
GD442_RS09315	COG1285	pathogenesis
GD442_RS09320	COG1247	-acetyltransferase
GD442_RS09330	COG4264	IucA IucC family
GD442_RS09335	COG0318	PFAM AMP-dependent synthetase and ligase
GD442_RS09350	COG1082	Xylose isomerase domain protein TIM barrel
GD442_RS09360	COG2814	Major facilitator Superfamily
GD442_RS09365	COG1279	arginine transmembrane transporter activity
GD442_RS09370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD442_RS09380	COG1752	Esterase of the alpha-beta hydrolase superfamily
GD442_RS09415	COG0577	efflux transmembrane transporter activity
GD442_RS09420	COG2002	toxin-antitoxin pair type II binding
GD442_RS09425	COG1404	Belongs to the peptidase S8 family
GD442_RS09440	COG3152	Membrane
GD442_RS09465	COG0840	transmembrane signaling receptor activity
GD442_RS09480	COG3949	Membrane
GD442_RS09485	COG0783	Belongs to the Dps family
GD442_RS09500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GD442_RS09510	COG1231	oxidoreductase activity
GD442_RS09515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS09520	COG4989	oxidoreductase activity
GD442_RS09525	COG0523	cobalamin synthesis protein
GD442_RS09530	COG0456	acetyltransferase
GD442_RS09535	COG0803	Belongs to the bacterial solute-binding protein 9 family
GD442_RS09540	COG0702	epimerase
GD442_RS09550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GD442_RS09560	COG4166	transmembrane transport
GD442_RS09585	COG5337	Spore coat protein CotH
GD442_RS09590	COG1051	belongs to the nudix hydrolase family
GD442_RS09595	COG0586	Pfam SNARE associated Golgi protein
GD442_RS09600	COG2244	polysaccharide biosynthetic process
GD442_RS09610	COG0701	Predicted permease
GD442_RS09615	COG3689	TIGRFAM TIGR03943 family protein
GD442_RS09620	COG1607	acyl-coa hydrolase
GD442_RS09630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GD442_RS09645	COG0702	epimerase
GD442_RS09650	COG2839	Protein conserved in bacteria
GD442_RS09655	COG1253	flavin adenine dinucleotide binding
GD442_RS09670	COG1114	Component of the transport system for branched-chain amino acids
GD442_RS09675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GD442_RS09695	COG0860	N-Acetylmuramoyl-L-alanine amidase
GD442_RS09705	COG1876	peptidase activity
GD442_RS09715	COG0154	amidase activity
GD442_RS09720	COG2211	Major facilitator Superfamily
GD442_RS09735	COG0860	N-Acetylmuramoyl-L-alanine amidase
GD442_RS09745	COG0561	phosphatase activity
GD442_RS09750	COG1846	Transcriptional regulator
GD442_RS09755	COG2814	Major facilitator Superfamily
GD442_RS09765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GD442_RS09775	COG1819	glycosyl
GD442_RS09780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS09785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD442_RS09815	COG0456	acetyltransferase
GD442_RS09835	COG0842	Transport permease protein
GD442_RS09835	COG1511	domain protein
GD442_RS09850	COG4499	WXG100 protein secretion system (Wss), protein YukC
GD442_RS09930	COG3646	Phage regulatory protein
GD442_RS09930	COG3645	SOS response
GD442_RS09980	COG4974	Belongs to the 'phage' integrase family
GD442_RS09990	COG3874	Sporulation protein YtfJ
GD442_RS10015	COG2226	methyltransferase
GD442_RS10040	COG0346	lactoylglutathione lyase activity
GD442_RS10050	COG0604	alcohol dehydrogenase
GD442_RS10055	COG1595	DNA-templated transcription, initiation
GD442_RS10070	COG0426	domain, Protein
GD442_RS10070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GD442_RS10080	COG0386	Belongs to the glutathione peroxidase family
GD442_RS10085	COG1305	Transglutaminase-like
GD442_RS10090	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GD442_RS10095	COG0714	Associated with various cellular activities
GD442_RS10100	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GD442_RS10105	COG1140	nitrate reductase beta subunit
GD442_RS10110	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GD442_RS10115	COG2181	nitrate reductase activity
GD442_RS10120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GD442_RS10125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GD442_RS10130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GD442_RS10135	COG0303	'Molybdopterin
GD442_RS10140	COG0314	molybdopterin synthase activity
GD442_RS10150	COG2223	nitrite transmembrane transporter activity
GD442_RS10170	COG1648	precorrin-2 dehydrogenase activity
GD442_RS10180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GD442_RS10180	COG1587	Uroporphyrinogen-III synthase
GD442_RS10185	COG2146	nitrite reductase [NAD(P)H] activity
GD442_RS10190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GD442_RS10195	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GD442_RS10230	COG2359	stage V sporulation protein S
GD442_RS10255	COG0457	Tetratricopeptide repeat
GD442_RS10270	COG1418	mRNA catabolic process
GD442_RS10275	COG0488	(ABC) transporter
GD442_RS10290	COG0629	single-stranded DNA binding
GD442_RS10295	COG1413	lyase activity
GD442_RS10310	COG2521	methyltransferase
GD442_RS10310	COG2136	Putative SAM-dependent methyltransferase
GD442_RS10315	COG0018	arginyl-trna synthetase
GD442_RS10365	COG0017	Asparaginyl-tRNA synthetase
GD442_RS10370	COG0733	neurotransmitter:sodium symporter activity
GD442_RS10395	COG2610	gluconate transmembrane transporter activity
GD442_RS10405	COG1794	racemase activity, acting on amino acids and derivatives
GD442_RS10415	COG0456	acetyltransferase
GD442_RS10425	COG3655	Transcriptional regulator
GD442_RS10430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GD442_RS10440	COG1131	(ABC) transporter
GD442_RS10445	COG4473	ABC transporter
GD442_RS10455	COG0546	phosphoglycolate phosphatase activity
GD442_RS10470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GD442_RS10485	COG0768	penicillin binding
GD442_RS10495	COG0204	Acyl-transferase
GD442_RS10500	COG1272	protein, Hemolysin III
GD442_RS10510	COG0805	protein transport
GD442_RS10520	COG1307	EDD domain protein, DegV family
GD442_RS10525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GD442_RS10530	COG1999	signal sequence binding
GD442_RS10535	COG0071	Belongs to the small heat shock protein (HSP20) family
GD442_RS10540	COG0367	asparagine synthase
GD442_RS10555	COG0860	N-Acetylmuramoyl-L-alanine amidase
GD442_RS10560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GD442_RS10565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GD442_RS10580	COG1335	isochorismatase
GD442_RS10590	COG0668	transmembrane transport
GD442_RS10595	COG4585	Histidine kinase
GD442_RS10595	COG2203	Gaf domain
GD442_RS10600	COG2197	response regulator
GD442_RS10605	COG1737	Transcriptional regulator
GD442_RS10610	COG0384	phenazine biosynthesis protein PhzF
GD442_RS10615	COG1064	alcohol dehydrogenase
GD442_RS10640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GD442_RS10675	COG1125	glycine betaine transport
GD442_RS10675	COG0517	IMP dehydrogenase activity
GD442_RS10680	COG1174	glycine betaine transport
GD442_RS10715	COG1253	flavin adenine dinucleotide binding
GD442_RS10720	COG1012	belongs to the aldehyde dehydrogenase family
GD442_RS10725	COG5506	Protein of unknown function (DUF1694)
GD442_RS10740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GD442_RS10745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GD442_RS10750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GD442_RS10755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GD442_RS10760	COG0456	acetyltransferase
GD442_RS10765	COG3829	transcription factor binding
GD442_RS10770	COG1509	lysine 2,3-aminomutase activity
GD442_RS10805	COG4991	sh3 domain protein
GD442_RS10805	COG3064	Membrane
GD442_RS10805	COG0515	serine threonine protein kinase
GD442_RS10815	COG0671	phosphoesterase, PA-phosphatase related
GD442_RS10820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GD442_RS10825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GD442_RS10910	COG0300	oxidoreductase activity
GD442_RS10930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GD442_RS10930	COG4499	WXG100 protein secretion system (Wss), protein YukC
GD442_RS10940	COG2814	Major facilitator Superfamily
GD442_RS10945	COG4841	protein insertion into membrane
GD442_RS10950	COG0372	Belongs to the citrate synthase family
GD442_RS10955	COG2079	MmgE PrpD family protein
GD442_RS10960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GD442_RS10965	COG1960	acyl-CoA dehydrogenase activity
GD442_RS10970	COG2084	Dehydrogenase
GD442_RS10980	COG1280	lysine exporter protein (LysE YggA)
GD442_RS10985	COG1024	Enoyl-CoA hydratase
GD442_RS11000	COG0420	3'-5' exonuclease activity
GD442_RS11005	COG0419	ATPase involved in DNA repair
GD442_RS11025	COG2223	nitrite transmembrane transporter activity
GD442_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS11035	COG1169	isochorismate synthase
GD442_RS11040	COG1021	2,3-dihydroxybenzoate-AMP ligase
GD442_RS11045	COG1535	isochorismatase
GD442_RS11045	COG3433	isochorismatase activity
GD442_RS11050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GD442_RS11055	COG3251	PFAM MbtH domain protein
GD442_RS11060	COG2814	Major facilitator Superfamily
GD442_RS11075	COG0776	regulation of translation
GD442_RS11085	COG2318	DinB family
GD442_RS11095	COG1115	amino acid carrier protein
GD442_RS11115	COG1187	pseudouridine synthase activity
GD442_RS11120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GD442_RS11125	COG1136	(ABC) transporter
GD442_RS11150	COG0028	Belongs to the TPP enzyme family
GD442_RS11190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GD442_RS11210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS11245	COG1247	-acetyltransferase
GD442_RS11280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS11310	COG0583	DNA-binding transcription factor activity
GD442_RS11315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GD442_RS11335	COG0583	DNA-binding transcription factor activity
GD442_RS11340	COG2258	MOSC domain
GD442_RS11355	COG1132	(ABC) transporter
GD442_RS11360	COG1132	(ABC) transporter
GD442_RS11390	COG1396	sequence-specific DNA binding
GD442_RS11420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GD442_RS11425	COG1595	DNA-templated transcription, initiation
GD442_RS11445	COG1649	PFAM Uncharacterised BCR, COG1649
GD442_RS11470	COG2971	BadF BadG BcrA BcrD
GD442_RS11480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GD442_RS11490	COG1846	Transcriptional regulator
GD442_RS11510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS11535	COG1309	transcriptional regulator
GD442_RS11640	COG3615	Tellurite resistance protein tehB
GD442_RS11640	COG0500	methyltransferase
GD442_RS11650	COG2226	methyltransferase
GD442_RS11655	COG3961	Belongs to the TPP enzyme family
GD442_RS11660	COG1846	Transcriptional regulator
GD442_RS11690	COG2195	Cleaves the N-terminal amino acid of tripeptides
GD442_RS11720	COG2002	toxin-antitoxin pair type II binding
GD442_RS11730	COG0730	response to heat
GD442_RS11735	COG0110	maltose O-acetyltransferase activity
GD442_RS11740	COG1686	Belongs to the peptidase S11 family
GD442_RS11755	COG2814	Major facilitator Superfamily
GD442_RS11790	COG2312	Erythromycin esterase
GD442_RS11795	COG0741	lytic transglycosylase activity
GD442_RS11800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS11835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GD442_RS11840	COG0768	penicillin binding
GD442_RS11845	COG1595	DNA-templated transcription, initiation
GD442_RS11855	COG0768	penicillin binding
GD442_RS11880	COG1131	(ABC) transporter
GD442_RS11890	COG1309	transcriptional regulator
GD442_RS11905	COG1960	acyl-CoA dehydrogenase activity
GD442_RS11910	COG0439	Biotin carboxylase
GD442_RS11915	COG0511	ligase activity, forming carbon-carbon bonds
GD442_RS11920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GD442_RS11925	COG1024	Enoyl-CoA hydratase
GD442_RS11930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GD442_RS11935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GD442_RS11955	COG0572	uridine kinase
GD442_RS11975	COG1686	Belongs to the peptidase S11 family
GD442_RS12000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GD442_RS12015	COG3227	Zinc metalloprotease (Elastase)
GD442_RS12020	COG2207	Transcriptional regulator
GD442_RS12050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GD442_RS12060	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS12065	COG1733	regulation of RNA biosynthetic process
GD442_RS12110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD442_RS12115	COG2368	4-hydroxyphenylacetate
GD442_RS12130	COG1063	alcohol dehydrogenase
GD442_RS12140	COG2323	membrane
GD442_RS12145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GD442_RS12155	COG3386	PFAM SMP-30 Gluconolaconase
GD442_RS12165	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GD442_RS12170	COG3773	Cell wall hydrolase
GD442_RS12175	COG0596	Alpha beta hydrolase
GD442_RS12185	COG0745	RESPONSE REGULATOR receiver
GD442_RS12190	COG2205	protein histidine kinase activity
GD442_RS12215	COG0825	malonyl-CoA metabolic process
GD442_RS12225	COG1136	(ABC) transporter
GD442_RS12230	COG0577	efflux transmembrane transporter activity
GD442_RS12250	COG0460	homoserine dehydrogenase
GD442_RS12255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD442_RS12265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GD442_RS12320	COG2124	cytochrome p450
GD442_RS12355	COG0561	phosphatase activity
GD442_RS12360	COG5002	protein histidine kinase activity
GD442_RS12375	COG1819	glycosyl
GD442_RS12380	COG1794	racemase activity, acting on amino acids and derivatives
GD442_RS12405	COG2205	protein histidine kinase activity
GD442_RS12420	COG0604	alcohol dehydrogenase
GD442_RS12425	COG0671	phosphoesterase, PA-phosphatase related
GD442_RS12475	COG2814	Major facilitator Superfamily
GD442_RS12480	COG4978	Transcriptional regulator
GD442_RS12480	COG0789	Transcriptional regulator
GD442_RS12500	COG0584	glycerophosphoryl diester phosphodiesterase
GD442_RS12520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD442_RS12525	COG0697	spore germination
GD442_RS12565	COG2223	nitrite transmembrane transporter activity
GD442_RS12580	COG0592	DNA-directed DNA polymerase activity
GD442_RS12600	COG3878	Protein conserved in bacteria
GD442_RS12620	COG4667	esterase of the alpha-beta hydrolase superfamily
GD442_RS12660	COG0322	excinuclease ABC activity
GD442_RS12700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GD442_RS12735	COG0745	RESPONSE REGULATOR receiver
GD442_RS12740	COG5002	protein histidine kinase activity
GD442_RS12755	COG1136	(ABC) transporter
GD442_RS12760	COG0577	efflux transmembrane transporter activity
GD442_RS12765	COG1073	alpha beta
GD442_RS12775	COG1523	belongs to the glycosyl hydrolase 13 family
GD442_RS12780	COG3227	Zinc metalloprotease (Elastase)
GD442_RS12785	COG0737	Belongs to the 5'-nucleotidase family
GD442_RS12805	COG0201	protein transport
GD442_RS12810	COG0697	spore germination
GD442_RS12815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD442_RS12825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GD442_RS12855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS12870	COG2959	enzyme of heme biosynthesis
GD442_RS12875	COG3409	Peptidoglycan-binding domain 1 protein
GD442_RS12875	COG3773	Cell wall hydrolase
GD442_RS12910	COG1309	transcriptional regulator
GD442_RS12930	COG3284	Transcriptional regulator
GD442_RS12945	COG1349	DNA-binding transcription factor activity
GD442_RS12960	COG1959	2 iron, 2 sulfur cluster binding
GD442_RS12975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GD442_RS12980	COG0508	dehydrogenase complex catalyzes the overall conversion of
GD442_RS12985	COG0022	dehydrogenase e1 component
GD442_RS12990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GD442_RS13000	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS13005	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GD442_RS13005	COG0456	acetyltransferase
GD442_RS13045	COG4176	ABC-type proline glycine betaine transport system permease component
GD442_RS13050	COG0517	IMP dehydrogenase activity
GD442_RS13050	COG4175	Glycine betaine
GD442_RS13080	COG2153	protein acetylation
GD442_RS13085	COG3397	chitin binding
GD442_RS13090	COG1819	glycosyl
GD442_RS13110	COG2205	protein histidine kinase activity
GD442_RS13115	COG2226	methyltransferase
GD442_RS13120	COG2315	Protein conserved in bacteria
GD442_RS13160	COG0456	acetyltransferase
GD442_RS13165	COG3973	AAA domain
GD442_RS13180	COG0514	ATP-dependent DNA helicase (RecQ)
GD442_RS13210	COG4637	Psort location Cytoplasmic, score
GD442_RS13225	COG3397	chitin binding
GD442_RS13240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GD442_RS13245	COG1115	amino acid carrier protein
GD442_RS13250	COG1012	belongs to the aldehyde dehydrogenase family
GD442_RS13255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GD442_RS13265	COG3938	Belongs to the proline racemase family
GD442_RS13270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GD442_RS13310	COG0586	Pfam SNARE associated Golgi protein
GD442_RS13320	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GD442_RS13330	COG4166	transmembrane transport
GD442_RS13340	COG4948	Mandelate Racemase Muconate Lactonizing
GD442_RS13355	COG0667	Aldo Keto reductase
GD442_RS13400	COG5002	protein histidine kinase activity
GD442_RS13400	COG3850	Histidine kinase
GD442_RS13405	COG0745	RESPONSE REGULATOR receiver
GD442_RS13445	COG1164	Oligoendopeptidase f
GD442_RS13450	COG1307	EDD domain protein, DegV family
GD442_RS13490	COG2814	Major facilitator Superfamily
GD442_RS13500	COG1664	Polymer-forming cytoskeletal
GD442_RS13505	COG0789	Transcriptional regulator
GD442_RS13510	COG4533	DNA binding
GD442_RS13515	COG0477	Major facilitator Superfamily
GD442_RS13515	COG2814	Major facilitator Superfamily
GD442_RS13535	COG2261	transglycosylase associated protein
GD442_RS13550	COG2226	methyltransferase
GD442_RS13585	COG0436	Aminotransferase
GD442_RS13590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GD442_RS13615	COG1131	(ABC) transporter
GD442_RS13665	COG0628	permease
GD442_RS13675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GD442_RS13680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GD442_RS13685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GD442_RS13725	COG2746	aminoglycoside 3-N-acetyltransferase activity
GD442_RS13735	COG0697	spore germination
GD442_RS13740	COG2318	DinB family
GD442_RS13760	COG4912	Dna alkylation repair
GD442_RS13765	COG0346	lactoylglutathione lyase activity
GD442_RS13770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS13775	COG0726	polysaccharide deacetylase
GD442_RS13785	COG0861	Integral membrane protein TerC family
GD442_RS13790	COG1368	sulfuric ester hydrolase activity
GD442_RS13795	COG0488	(ABC) transporter
GD442_RS13805	COG2409	Drug exporters of the RND superfamily
GD442_RS13805	COG1033	growth of symbiont in host cell
GD442_RS13810	COG1309	transcriptional regulator
GD442_RS13825	COG0287	Prephenate dehydrogenase
GD442_RS13840	COG1605	Chorismate mutase
GD442_RS13840	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GD442_RS13885	COG1388	LysM domain
GD442_RS13885	COG3584	3D domain protein
GD442_RS13895	COG0346	lactoylglutathione lyase activity
GD442_RS13925	COG1879	ABC-type sugar transport system periplasmic component
GD442_RS13930	COG1172	Belongs to the binding-protein-dependent transport system permease family
GD442_RS13935	COG1172	Belongs to the binding-protein-dependent transport system permease family
GD442_RS13945	COG2390	Transcriptional regulator
GD442_RS13950	COG1070	Carbohydrate kinase
GD442_RS13970	COG2329	Antibiotic biosynthesis monooxygenase
GD442_RS13990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GD442_RS14005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GD442_RS14010	COG4187	Peptidase family M20/M25/M40
GD442_RS14015	COG1414	Transcriptional regulator
GD442_RS14020	COG0833	amino acid
GD442_RS14030	COG3239	Fatty acid desaturase
GD442_RS14040	COG2720	vancomycin resistance protein
GD442_RS14045	COG1785	Belongs to the alkaline phosphatase family
GD442_RS14055	COG3655	Transcriptional regulator
GD442_RS14075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS14080	COG0346	lactoylglutathione lyase activity
GD442_RS14105	COG0714	Associated with various cellular activities
GD442_RS14130	COG0463	Glycosyl transferase, family 2
GD442_RS14160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GD442_RS14165	COG0753	catalase activity
GD442_RS14205	COG0714	Associated with various cellular activities
GD442_RS14270	COG0778	Nitroreductase
GD442_RS14275	COG1846	Transcriptional regulator
GD442_RS14295	COG3831	ATPase activity
GD442_RS14295	COG4884	unkown
GD442_RS14320	COG0590	tRNA wobble adenosine to inosine editing
GD442_RS14320	COG0037	tRNA processing
GD442_RS14325	COG0456	acetyltransferase
GD442_RS14340	COG0697	spore germination
GD442_RS14345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD442_RS14400	COG0730	response to heat
GD442_RS14410	COG0833	amino acid
GD442_RS14420	COG4335	DNA alkylation repair
GD442_RS14490	COG1984	allophanate hydrolase subunit 2
GD442_RS14495	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GD442_RS14500	COG1414	Transcriptional regulator
GD442_RS14515	COG0640	Transcriptional regulator
GD442_RS14525	COG1960	acyl-CoA dehydrogenase activity
GD442_RS14560	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GD442_RS14585	COG3848	Pyruvate phosphate dikinase
GD442_RS14585	COG0574	Belongs to the PEP-utilizing enzyme family
GD442_RS14590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS14610	COG1063	alcohol dehydrogenase
GD442_RS14615	COG1027	Aspartate ammonia-lyase
GD442_RS14620	COG0252	asparaginase activity
GD442_RS14625	COG1396	sequence-specific DNA binding
GD442_RS14660	COG5002	protein histidine kinase activity
GD442_RS14685	COG2207	Transcriptional regulator
GD442_RS14700	COG0322	excinuclease ABC activity
GD442_RS14705	COG0531	amino acid
GD442_RS14710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GD442_RS14720	COG0531	amino acid
GD442_RS14725	COG0697	spore germination
GD442_RS14730	COG0784	Response regulator, receiver
GD442_RS14735	COG4191	Histidine kinase
GD442_RS14745	COG1115	amino acid carrier protein
GD442_RS14755	COG2124	cytochrome p450
GD442_RS14770	COG0737	Belongs to the 5'-nucleotidase family
GD442_RS14775	COG2267	carboxylic ester hydrolase activity
GD442_RS14780	COG1335	isochorismatase
GD442_RS14800	COG0583	DNA-binding transcription factor activity
GD442_RS14805	COG1846	Transcriptional regulator
GD442_RS14810	COG0598	Magnesium transport protein CorA
GD442_RS14830	COG1073	alpha beta
GD442_RS14850	COG0415	Belongs to the DNA photolyase family
GD442_RS14865	COG0288	reversible hydration of carbon dioxide
GD442_RS14875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GD442_RS14880	COG5609	conserved protein (DUF2294)
GD442_RS14895	COG0697	spore germination
GD442_RS14900	COG0726	polysaccharide deacetylase
GD442_RS14910	COG1575	Belongs to the MenA family. Type 1 subfamily
GD442_RS14920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS14930	COG0798	PFAM Bile acid sodium symporter
GD442_RS14935	COG0346	lactoylglutathione lyase activity
GD442_RS14940	COG0640	Transcriptional regulator
GD442_RS14950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GD442_RS14955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GD442_RS14955	COG3320	Male sterility
GD442_RS14965	COG2814	Major facilitator Superfamily
GD442_RS14970	COG1309	transcriptional regulator
GD442_RS14975	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS14980	COG1522	sequence-specific DNA binding
GD442_RS14995	COG0346	lactoylglutathione lyase activity
GD442_RS15070	COG0745	RESPONSE REGULATOR receiver
GD442_RS15075	COG5002	protein histidine kinase activity
GD442_RS15075	COG3850	Histidine kinase
GD442_RS15115	COG1136	(ABC) transporter
GD442_RS15150	COG2814	Major facilitator Superfamily
GD442_RS15165	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GD442_RS15180	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GD442_RS15195	COG0577	efflux transmembrane transporter activity
GD442_RS15215	COG3850	Histidine kinase
GD442_RS15215	COG5002	protein histidine kinase activity
GD442_RS15225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS15235	COG1619	proteins homologs of microcin C7 resistance protein MccF
GD442_RS15280	COG0814	amino acid
GD442_RS15285	COG1760	l-serine dehydratase
GD442_RS15290	COG1760	l-serine dehydratase
GD442_RS15300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GD442_RS15305	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GD442_RS15315	COG1335	isochorismatase
GD442_RS15320	COG1522	sequence-specific DNA binding
GD442_RS15325	COG0531	amino acid
GD442_RS15340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GD442_RS15360	COG0662	Cupin 2, conserved barrel domain protein
GD442_RS15365	COG2207	Transcriptional regulator
GD442_RS15365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GD442_RS15385	COG3409	Peptidoglycan-binding domain 1 protein
GD442_RS15385	COG5632	N-Acetylmuramoyl-L-alanine amidase
GD442_RS15470	COG5444	nuclease activity
GD442_RS15495	COG1876	peptidase activity
GD442_RS15500	COG2843	Capsule synthesis protein
GD442_RS15510	COG0477	Major facilitator Superfamily
GD442_RS15525	COG1846	Transcriptional regulator
GD442_RS15530	COG2814	Major facilitator Superfamily
GD442_RS15540	COG2031	fatty acid transporter
GD442_RS15550	COG2249	NAD(P)H dehydrogenase (quinone) activity
GD442_RS15605	COG1288	antiporter activity
GD442_RS15610	COG2356	endonuclease I
GD442_RS15625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GD442_RS15645	COG1733	regulation of RNA biosynthetic process
GD442_RS15650	COG0778	Nitroreductase
GD442_RS15680	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS15690	COG1131	(ABC) transporter
GD442_RS15715	COG1011	Hydrolase
GD442_RS15745	COG0180	Tryptophanyl-tRNA synthetase
GD442_RS15755	COG0628	permease
GD442_RS15780	COG0500	methyltransferase
GD442_RS15790	COG0477	Major facilitator Superfamily
GD442_RS15820	COG1253	flavin adenine dinucleotide binding
GD442_RS15825	COG0789	Transcriptional regulator
GD442_RS15835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GD442_RS15865	COG0697	spore germination
GD442_RS15875	COG1357	PFAM Pentapeptide repeats (8 copies)
GD442_RS15880	COG3813	Protein conserved in bacteria
GD442_RS15885	COG2706	6-phosphogluconolactonase activity
GD442_RS15890	COG1070	Carbohydrate kinase
GD442_RS15905	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GD442_RS15910	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GD442_RS15915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GD442_RS15925	COG0604	alcohol dehydrogenase
GD442_RS15930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GD442_RS15940	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS15955	COG0840	transmembrane signaling receptor activity
GD442_RS15965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD442_RS15965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD442_RS15970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GD442_RS15970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GD442_RS15975	COG1733	regulation of RNA biosynthetic process
GD442_RS15990	COG0656	L-ascorbic acid biosynthetic process
GD442_RS15995	COG2814	Major facilitator Superfamily
GD442_RS16020	COG2824	Alkylphosphonate utilization operon protein PhnA
GD442_RS16025	COG0659	secondary active sulfate transmembrane transporter activity
GD442_RS16040	COG0814	amino acid
GD442_RS16070	COG1733	regulation of RNA biosynthetic process
GD442_RS16075	COG2188	Transcriptional regulator
GD442_RS16080	COG0673	inositol 2-dehydrogenase activity
GD442_RS16085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GD442_RS16090	COG1733	regulation of RNA biosynthetic process
GD442_RS16095	COG1733	regulation of RNA biosynthetic process
GD442_RS16120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS16140	COG0384	phenazine biosynthesis protein PhzF
GD442_RS16160	COG0318	PFAM AMP-dependent synthetase and ligase
GD442_RS16165	COG2249	NAD(P)H dehydrogenase (quinone) activity
GD442_RS16170	COG1733	regulation of RNA biosynthetic process
GD442_RS16180	COG0726	polysaccharide deacetylase
GD442_RS16190	COG1191	sigma factor activity
GD442_RS16200	COG1280	lysine exporter protein (LysE YggA)
GD442_RS16235	COG3152	Membrane
GD442_RS16260	COG1151	hydroxylamine reductase activity
GD442_RS16270	COG3409	Peptidoglycan-binding domain 1 protein
GD442_RS16270	COG3757	hydrolase, family 25
GD442_RS16305	COG2072	flavoprotein involved in K transport
GD442_RS16340	COG1113	amino acid transport
GD442_RS16345	COG2814	Major facilitator Superfamily
GD442_RS16375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GD442_RS16380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GD442_RS16395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GD442_RS16400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS16405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS16410	COG3739	integral membrane protein
GD442_RS16430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS16445	COG0583	DNA-binding transcription factor activity
GD442_RS16480	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GD442_RS16485	COG1164	Oligoendopeptidase f
GD442_RS16505	COG3781	membrane
GD442_RS16520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GD442_RS16545	COG0584	glycerophosphoryl diester phosphodiesterase
GD442_RS16555	COG0640	Transcriptional regulator
GD442_RS16560	COG0604	alcohol dehydrogenase
GD442_RS16570	COG0457	Tetratricopeptide repeat
GD442_RS16585	COG0277	FAD linked oxidase domain protein
GD442_RS16610	COG1183	phosphatidylcholine synthase activity
GD442_RS16615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GD442_RS16615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS16620	COG1252	NADH dehydrogenase
GD442_RS16630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GD442_RS16640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GD442_RS16650	COG0457	Tetratricopeptide repeat
GD442_RS16720	COG3852	Histidine kinase
GD442_RS16730	COG1285	pathogenesis
GD442_RS16740	COG2514	catechol 2,3-dioxygenase activity
GD442_RS16745	COG2720	vancomycin resistance protein
GD442_RS16770	COG1278	Cold shock
GD442_RS16780	COG0716	FMN binding
GD442_RS16810	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS16820	COG0165	Argininosuccinate lyase
GD442_RS16835	COG4145	pantothenate transmembrane transporter activity
GD442_RS16845	COG1012	belongs to the aldehyde dehydrogenase family
GD442_RS16850	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS16860	COG1657	PFAM Prenyltransferase squalene oxidase
GD442_RS16865	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GD442_RS16870	COG2962	Rard protein
GD442_RS16875	COG3326	Membrane
GD442_RS16890	COG0489	protein tyrosine kinase activity
GD442_RS16900	COG0314	molybdopterin synthase activity
GD442_RS16905	COG0303	'Molybdopterin
GD442_RS16910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GD442_RS16915	COG2116	formate transmembrane transporter activity
GD442_RS16925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GD442_RS16930	COG5609	conserved protein (DUF2294)
GD442_RS16935	COG2427	Protein of unknown function (DUF1641)
GD442_RS16940	COG3383	formate dehydrogenase (NAD+) activity
GD442_RS16945	COG0697	spore germination
GD442_RS16960	COG0531	amino acid
GD442_RS16995	COG2226	methyltransferase
GD442_RS17000	COG4166	transmembrane transport
GD442_RS17005	COG4166	transmembrane transport
GD442_RS17010	COG4166	transmembrane transport
GD442_RS17015	COG1301	dicarboxylic acid transport
GD442_RS17020	COG1316	TRANSCRIPTIONal
GD442_RS17030	COG1595	DNA-templated transcription, initiation
GD442_RS17040	COG1131	(ABC) transporter
GD442_RS17060	COG0673	inositol 2-dehydrogenase activity
GD442_RS17065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GD442_RS17070	COG0187	DNA topoisomerase II activity
GD442_RS17075	COG1832	CoA-binding protein
GD442_RS17080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GD442_RS17085	COG0745	RESPONSE REGULATOR receiver
GD442_RS17105	COG4841	protein insertion into membrane
GD442_RS17110	COG0824	Thioesterase
GD442_RS17140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GD442_RS17150	COG2274	protein secretion by the type I secretion system
GD442_RS17155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GD442_RS17165	COG0726	polysaccharide deacetylase
GD442_RS17185	COG2211	Major facilitator Superfamily
GD442_RS17195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GD442_RS17210	COG0183	Belongs to the thiolase family
GD442_RS17215	COG0318	PFAM AMP-dependent synthetase and ligase
GD442_RS17220	COG1268	BioY protein
GD442_RS17225	COG0318	PFAM AMP-dependent synthetase and ligase
GD442_RS17270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS17280	COG5002	protein histidine kinase activity
GD442_RS17285	COG0400	carboxylic ester hydrolase activity
GD442_RS17290	COG0346	lactoylglutathione lyase activity
GD442_RS17295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GD442_RS17305	COG0069	glutamate synthase activity
GD442_RS17310	COG1902	pentaerythritol trinitrate reductase activity
GD442_RS17315	COG1329	Transcriptional regulator
GD442_RS17320	COG0010	Belongs to the arginase family
GD442_RS17370	COG4846	Membrane protein involved in cytochrome C biogenesis
GD442_RS17375	COG0785	Cytochrome C biogenesis protein
GD442_RS17395	COG1131	(ABC) transporter
GD442_RS17410	COG0583	DNA-binding transcription factor activity
GD442_RS17420	COG1346	cytolysis
GD442_RS17435	COG0730	response to heat
GD442_RS17460	COG1132	(ABC) transporter
GD442_RS17465	COG1132	(ABC) transporter
GD442_RS17490	COG3639	organic phosphonate transmembrane transporter activity
GD442_RS17500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD442_RS17505	COG0737	Belongs to the 5'-nucleotidase family
GD442_RS17515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GD442_RS17535	COG1695	Transcriptional regulator
GD442_RS17540	COG0174	glutamine synthetase
GD442_RS17545	COG0789	Transcriptional regulator
GD442_RS17550	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GD442_RS17555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GD442_RS17560	COG2860	membrane
GD442_RS17565	COG0464	growth
GD442_RS17595	COG3584	3D domain protein
GD442_RS17595	COG1388	LysM domain
GD442_RS17600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GD442_RS17600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GD442_RS17600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GD442_RS17605	COG1105	Belongs to the carbohydrate kinase PfkB family
GD442_RS17610	COG1349	DNA-binding transcription factor activity
GD442_RS17615	COG1979	alcohol dehydrogenase
GD442_RS17620	COG2322	membrane
GD442_RS17630	COG1113	amino acid transport
GD442_RS17640	COG1408	metallophosphoesterase
GD442_RS17645	COG2116	formate transmembrane transporter activity
GD442_RS17660	COG2217	Heavy metal translocating P-type atpase
GD442_RS17665	COG2608	mercury ion transmembrane transporter activity
GD442_RS17670	COG1937	Protein conserved in bacteria
GD442_RS17680	COG2819	hydrolase of the alpha beta superfamily
GD442_RS17685	COG1120	ATPase activity
GD442_RS17690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS17695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS17700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GD442_RS17705	COG0708	Exodeoxyribonuclease III
GD442_RS17710	COG2169	Transcriptional regulator
GD442_RS17715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GD442_RS17720	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GD442_RS17740	COG2267	carboxylic ester hydrolase activity
GD442_RS17745	COG5001	Diguanylate cyclase
GD442_RS17745	COG3300	MHYT domain
GD442_RS17765	COG1086	Polysaccharide biosynthesis protein
GD442_RS17785	COG1346	cytolysis
GD442_RS17795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GD442_RS17805	COG2188	Transcriptional regulator
GD442_RS17810	COG2723	6-phospho-beta-galactosidase activity
GD442_RS17820	COG1404	Belongs to the peptidase S8 family
GD442_RS17825	COG3773	Cell wall hydrolase
GD442_RS17835	COG1368	sulfuric ester hydrolase activity
GD442_RS17840	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GD442_RS17865	COG4550	Control of competence regulator ComK, YlbF/YmcA
GD442_RS17875	COG1013	pyruvate-flavodoxin oxidoreductase activity
GD442_RS17880	COG0674	pyruvate-flavodoxin oxidoreductase activity
GD442_RS17880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GD442_RS17890	COG2359	stage V sporulation protein S
GD442_RS17895	COG1692	metallophosphoesterase
GD442_RS17915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GD442_RS17920	COG1426	Protein conserved in bacteria
GD442_RS17935	COG0300	oxidoreductase activity
GD442_RS17940	COG0612	Peptidase, M16
GD442_RS17945	COG0612	Peptidase, M16
GD442_RS17970	COG2188	Transcriptional regulator
GD442_RS17985	COG0740	serine-type endopeptidase activity
GD442_RS17990	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GD442_RS18000	COG0527	aspartate kinase activity
GD442_RS18005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GD442_RS18010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GD442_RS18175	COG0582	viral genome integration into host DNA
GD442_RS18205	COG0305	Participates in initiation and elongation during chromosome replication
GD442_RS18245	COG1396	sequence-specific DNA binding
GD442_RS18275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GD442_RS18280	COG1873	PFAM PRC-barrel domain
GD442_RS18285	COG0612	Peptidase, M16
GD442_RS18290	COG0726	polysaccharide deacetylase
GD442_RS18305	COG0196	riboflavin kinase activity
GD442_RS18320	COG1550	Protein conserved in bacteria
GD442_RS18330	COG1358	cellular component organization or biogenesis
GD442_RS18335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GD442_RS18340	COG0195	Participates in both transcription termination and antitermination
GD442_RS18360	COG0750	zinc metalloprotease
GD442_RS18370	COG4589	Belongs to the CDS family
GD442_RS18415	COG4974	Belongs to the 'phage' integrase family
GD442_RS18425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GD442_RS18430	COG0758	DNA mediated transformation
GD442_RS18435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GD442_RS18475	COG1837	Belongs to the UPF0109 family
GD442_RS18485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GD442_RS18495	COG0552	protein localization to endoplasmic reticulum
GD442_RS18500	COG1196	nuclear chromosome segregation
GD442_RS18515	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS18520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GD442_RS18535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GD442_RS18540	COG1461	Dihydroxyacetone kinase
GD442_RS18545	COG1302	Protein conserved in bacteria
GD442_RS18560	COG1564	THIamine pyrophosphokinase
GD442_RS18565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GD442_RS18575	COG0515	serine threonine protein kinase
GD442_RS18575	COG2815	serine threonine protein kinase
GD442_RS18580	COG0631	protein serine/threonine phosphatase activity
GD442_RS18590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GD442_RS18590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GD442_RS18605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GD442_RS18610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GD442_RS18630	COG1561	YicC-like family, N-terminal region
GD442_RS18635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GD442_RS18645	COG0006	proline dipeptidase activity
GD442_RS18655	COG3069	C4-dicarboxylate transmembrane transporter activity
GD442_RS18715	COG0564	pseudouridine synthase activity
GD442_RS18735	COG3599	regulation of cell shape
GD442_RS18740	COG2302	S4 RNA-binding domain
GD442_RS18745	COG0762	integral membrane protein
GD442_RS18755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GD442_RS18765	COG1873	PFAM PRC-barrel domain
GD442_RS18770	COG1191	sigma factor activity
GD442_RS18775	COG1191	sigma factor activity
GD442_RS18785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GD442_RS18790	COG0849	cell division
GD442_RS18810	COG0772	Belongs to the SEDS family
GD442_RS18830	COG0768	penicillin binding
GD442_RS18855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GD442_RS18875	COG1399	metal-binding, possibly nucleic acid-binding protein
GD442_RS18885	COG3480	Lon protease (S16) C-terminal proteolytic domain
GD442_RS18890	COG1752	Esterase of the alpha-beta hydrolase superfamily
GD442_RS18895	COG3314	Sporulation integral membrane protein YlbJ
GD442_RS18905	COG0742	ribosomal rna small subunit methyltransferase
GD442_RS18925	COG3679	Belongs to the UPF0342 family
GD442_RS18930	COG0406	alpha-ribazole phosphatase activity
GD442_RS18945	COG2340	Cysteine-rich secretory protein family
GD442_RS18960	COG3336	cytochrome c oxidase
GD442_RS18995	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GD442_RS19000	COG0772	Belongs to the SEDS family
GD442_RS19010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GD442_RS19015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GD442_RS19025	COG4896	Protein conserved in bacteria
GD442_RS19050	COG0483	inositol monophosphate 1-phosphatase activity
GD442_RS19070	COG1982	Orn Lys Arg decarboxylase major
GD442_RS19120	COG0022	dehydrogenase e1 component
GD442_RS19125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GD442_RS19140	COG0561	phosphatase activity
GD442_RS19150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GD442_RS19155	COG0569	domain protein
GD442_RS19175	COG0583	DNA-binding transcription factor activity
GD442_RS19180	COG0517	IMP dehydrogenase activity
GD442_RS19190	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GD442_RS19195	COG4703	Protein of unknown function (DUF1797)
GD442_RS19210	COG2200	EAL domain
GD442_RS19215	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS19220	COG1408	metallophosphoesterase
GD442_RS19270	COG2814	Major facilitator Superfamily
GD442_RS19290	COG3209	COG3209 Rhs family protein
GD442_RS19300	COG2205	protein histidine kinase activity
GD442_RS19310	COG0436	Aminotransferase
GD442_RS19315	COG1609	Transcriptional regulator
GD442_RS19320	COG3833	ABC-type maltose transport systems, permease component
GD442_RS19325	COG1175	transmembrane transport
GD442_RS19330	COG2182	Extracellular solute-binding protein
GD442_RS19340	COG0366	Alpha amylase catalytic
GD442_RS19345	COG3842	ATPase activity
GD442_RS19385	COG0183	Belongs to the thiolase family
GD442_RS19420	COG1695	Transcriptional regulator
GD442_RS19425	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS19445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GD442_RS19450	COG0436	Aminotransferase
GD442_RS19485	COG2084	Dehydrogenase
GD442_RS19495	COG2203	Gaf domain
GD442_RS19495	COG2199	diguanylate cyclase activity
GD442_RS19500	COG0778	Nitroreductase
GD442_RS19525	COG1263	PTS System
GD442_RS19525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GD442_RS19525	COG2190	(PTS) system
GD442_RS19530	COG3711	transcriptional antiterminator
GD442_RS19550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GD442_RS19575	COG1547	Domain of unknown function (DUF309)
GD442_RS19580	COG0456	acetyltransferase
GD442_RS19585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GD442_RS19590	COG4086	secreted protein
GD442_RS19595	COG0561	phosphatase activity
GD442_RS19600	COG0697	spore germination
GD442_RS19615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GD442_RS19640	COG0733	neurotransmitter:sodium symporter activity
GD442_RS19660	COG1686	Belongs to the peptidase S11 family
GD442_RS19665	COG1725	Transcriptional regulator
GD442_RS19670	COG1131	(ABC) transporter
GD442_RS19690	COG1846	Transcriptional regulator
GD442_RS19705	COG0598	Magnesium transport protein CorA
GD442_RS19730	COG4974	Belongs to the 'phage' integrase family
GD442_RS19740	COG0735	belongs to the Fur family
GD442_RS19745	COG1300	Membrane
GD442_RS19765	COG0667	Aldo Keto reductase
GD442_RS19770	COG0656	L-ascorbic acid biosynthetic process
GD442_RS19775	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GD442_RS19775	COG0456	acetyltransferase
GD442_RS19785	COG0737	Belongs to the 5'-nucleotidase family
GD442_RS19785	COG4085	toxin activity
GD442_RS19785	COG1525	nuclease
GD442_RS19795	COG0596	Alpha beta hydrolase
GD442_RS19800	COG2056	Na+-H+ antiporter family
GD442_RS19805	COG1609	Transcriptional regulator
GD442_RS19810	COG0456	acetyltransferase
GD442_RS19815	COG1073	alpha beta
GD442_RS19830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD442_RS19830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GD442_RS19835	COG0307	riboflavin synthase, alpha
GD442_RS19865	COG1073	alpha beta
GD442_RS19865	COG2226	methyltransferase
GD442_RS19880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GD442_RS19895	COG0737	Belongs to the 5'-nucleotidase family
GD442_RS19905	COG1522	sequence-specific DNA binding
GD442_RS19950	COG0300	oxidoreductase activity
GD442_RS19955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS19960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GD442_RS19965	COG1760	l-serine dehydratase
GD442_RS19970	COG1760	l-serine dehydratase
GD442_RS20000	COG1285	pathogenesis
GD442_RS20010	COG2195	Cleaves the N-terminal amino acid of tripeptides
GD442_RS20015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS20030	COG1376	ErfK ybiS ycfS ynhG family protein
GD442_RS20035	COG4129	membrane
GD442_RS20040	COG1126	abc transporter atp-binding protein
GD442_RS20045	COG0765	amino acid transport
GD442_RS20050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GD442_RS20070	COG2323	membrane
GD442_RS20075	COG0772	Belongs to the SEDS family
GD442_RS20080	COG0508	dehydrogenase complex catalyzes the overall conversion of
GD442_RS20085	COG0022	dehydrogenase e1 component
GD442_RS20090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GD442_RS20095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GD442_RS20105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GD442_RS20110	COG0280	phosphate acetyltransferase
GD442_RS20115	COG3829	transcription factor binding
GD442_RS20115	COG3290	protein histidine kinase activity
GD442_RS20125	COG0584	glycerophosphoryl diester phosphodiesterase
GD442_RS20130	COG3093	addiction module antidote protein HigA
GD442_RS20145	COG0750	zinc metalloprotease
GD442_RS20150	COG0497	DNA recombination
GD442_RS20160	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GD442_RS20170	COG0142	geranyltranstransferase activity
GD442_RS20195	COG1302	Protein conserved in bacteria
GD442_RS20200	COG0439	Biotin carboxylase
GD442_RS20205	COG0511	ligase activity, forming carbon-carbon bonds
GD442_RS20250	COG3854	ATPases associated with a variety of cellular activities
GD442_RS20275	COG0006	proline dipeptidase activity
GD442_RS20290	COG3872	metal-dependent enzyme
GD442_RS20300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GD442_RS20335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GD442_RS20345	COG1609	Transcriptional regulator
GD442_RS20355	COG2076	Multidrug Resistance protein
GD442_RS20360	COG2076	Multidrug Resistance protein
GD442_RS20390	COG1131	(ABC) transporter
GD442_RS20395	COG1725	Transcriptional regulator
GD442_RS20425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GD442_RS20505	COG5632	N-Acetylmuramoyl-L-alanine amidase
GD442_RS20505	COG1388	LysM domain
GD442_RS20505	COG3409	Peptidoglycan-binding domain 1 protein
GD442_RS20510	COG4824	toxin secretion phage lysis holin
GD442_RS20635	COG0582	viral genome integration into host DNA
GD442_RS20665	COG0270	DNA (cytosine-5-)-methyltransferase activity
GD442_RS20715	COG2002	toxin-antitoxin pair type II binding
GD442_RS20800	COG1459	type II secretion system
GD442_RS20805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GD442_RS20860	COG1410	methionine synthase
GD442_RS20860	COG0646	methionine synthase
GD442_RS20865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GD442_RS20865	COG0646	methionine synthase
GD442_RS20870	COG0626	cystathionine gamma-synthase activity
GD442_RS20875	COG0626	cystathionine gamma-synthase activity
GD442_RS20895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS20905	COG1940	carbohydrate kinase activity
GD442_RS20910	COG4483	Protein conserved in bacteria
GD442_RS20915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GD442_RS20925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GD442_RS20935	COG0704	Plays a role in the regulation of phosphate uptake
GD442_RS20945	COG0573	inorganic phosphate transmembrane transporter activity
GD442_RS20950	COG0573	inorganic phosphate transmembrane transporter activity
GD442_RS20955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GD442_RS20965	COG0477	Major facilitator Superfamily
GD442_RS20970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GD442_RS20980	COG5521	maltodextrose utilization protein MalA
GD442_RS20995	COG0735	belongs to the Fur family
GD442_RS21000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GD442_RS21005	COG1121	(ABC) transporter
GD442_RS21010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS21040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GD442_RS21045	COG2384	SAM-dependent methyltransferase
GD442_RS21055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GD442_RS21060	COG0358	DNA primase activity
GD442_RS21070	COG0517	IMP dehydrogenase activity
GD442_RS21085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GD442_RS21090	COG0295	cytidine deaminase activity
GD442_RS21095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GD442_RS21105	COG1480	7TM receptor with intracellular HD hydrolase
GD442_RS21110	COG1702	phosphate starvation-inducible protein PhoH
GD442_RS21125	COG1610	YqeY-like protein
GD442_RS21135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GD442_RS21140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GD442_RS21170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GD442_RS21175	COG1733	regulation of RNA biosynthetic process
GD442_RS21200	COG1466	dna polymerase III delta subunit
GD442_RS21210	COG2333	competence protein COMEC
GD442_RS21210	COG0658	competence protein
GD442_RS21215	COG2131	deaminase
GD442_RS21220	COG1596	polysaccharide export
GD442_RS21220	COG1555	photosystem II stabilization
GD442_RS21225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GD442_RS21230	COG2226	methyltransferase
GD442_RS21235	COG0799	negative regulation of ribosome biogenesis
GD442_RS21240	COG1713	HD superfamily hydrolase involved in NAD metabolism
GD442_RS21250	COG1534	Rna-binding protein
GD442_RS21260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GD442_RS21265	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GD442_RS21280	COG1191	sigma factor activity
GD442_RS21300	COG0778	Nitroreductase
GD442_RS21305	COG2357	RelA SpoT domain protein
GD442_RS21315	COG1785	Belongs to the alkaline phosphatase family
GD442_RS21325	COG2267	carboxylic ester hydrolase activity
GD442_RS21365	COG1404	Belongs to the peptidase S8 family
GD442_RS21370	COG3186	Phenylalanine-4-hydroxylase
GD442_RS21380	COG2514	catechol 2,3-dioxygenase activity
GD442_RS21385	COG2259	Doxx family
GD442_RS21425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GD442_RS21435	COG1012	belongs to the aldehyde dehydrogenase family
GD442_RS21435	COG1454	alcohol dehydrogenase
GD442_RS21440	COG0626	cystathionine gamma-synthase activity
GD442_RS21445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GD442_RS21470	COG0768	penicillin binding
GD442_RS21505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GD442_RS21535	COG0628	permease
GD442_RS21555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GD442_RS21570	COG1104	cysteine desulfurase activity
GD442_RS21575	COG1959	2 iron, 2 sulfur cluster binding
GD442_RS21580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GD442_RS21590	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GD442_RS21610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GD442_RS21620	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GD442_RS21620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GD442_RS21625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GD442_RS21630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GD442_RS21630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GD442_RS21640	COG2244	polysaccharide biosynthetic process
GD442_RS21645	COG2323	membrane
GD442_RS21655	COG1862	Preprotein translocase
GD442_RS21685	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GD442_RS21715	COG0157	Belongs to the NadC ModD family
GD442_RS21720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GD442_RS21725	COG1104	cysteine desulfurase activity
GD442_RS21730	COG1827	regulation of RNA biosynthetic process
GD442_RS21735	COG2258	MOSC domain
GD442_RS21740	COG0077	Prephenate dehydratase
GD442_RS21745	COG0577	efflux transmembrane transporter activity
GD442_RS21750	COG0577	efflux transmembrane transporter activity
GD442_RS21755	COG1136	(ABC) transporter
GD442_RS21760	COG5002	protein histidine kinase activity
GD442_RS21765	COG0745	RESPONSE REGULATOR receiver
GD442_RS21775	COG3290	protein histidine kinase activity
GD442_RS21790	COG1530	ribonuclease E activity
GD442_RS21795	COG1994	Peptidase M50
GD442_RS21800	COG0739	heme binding
GD442_RS21805	COG2894	cell division
GD442_RS21820	COG1792	Involved in formation and maintenance of cell shape
GD442_RS21825	COG1077	Cell shape determining protein MreB Mrl
GD442_RS21845	COG0285	dihydrofolate synthase activity
GD442_RS21860	COG1388	LysM domain
GD442_RS21870	COG0113	porphobilinogen synthase activity
GD442_RS21875	COG1587	Uroporphyrinogen-III synthase
GD442_RS21885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GD442_RS21895	COG1846	Transcriptional regulator
GD442_RS21900	COG1764	response to oxidative stress
GD442_RS21915	COG1067	ATP-dependent peptidase activity
GD442_RS21915	COG0470	DNA polymerase III
GD442_RS21960	COG0622	Phosphoesterase
GD442_RS21975	COG5401	PFAM Sporulation and spore germination
GD442_RS21995	COG1309	transcriptional regulator
GD442_RS22005	COG2197	response regulator
GD442_RS22080	COG2197	response regulator
GD442_RS22085	COG2233	PERMEase
GD442_RS22090	COG0402	S-adenosylhomocysteine deaminase activity
GD442_RS22095	COG1983	PspC domain protein
GD442_RS22100	COG1396	sequence-specific DNA binding
GD442_RS22105	COG0697	spore germination
GD442_RS22115	COG1959	2 iron, 2 sulfur cluster binding
GD442_RS22120	COG1668	transmembrane transport
GD442_RS22125	COG4152	abc transporter atp-binding protein
GD442_RS22130	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GD442_RS22135	COG1360	Flagellar Motor Protein
GD442_RS22140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GD442_RS22145	COG1876	peptidase activity
GD442_RS22150	COG0824	Thioesterase
GD442_RS22155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GD442_RS22160	COG1053	succinate dehydrogenase
GD442_RS22165	COG2009	succinate dehydrogenase
GD442_RS22170	COG1719	4-vinyl reductase, 4VR
GD442_RS22180	COG3118	belongs to the thioredoxin family
GD442_RS22185	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GD442_RS22190	COG2086	electron transfer activity
GD442_RS22195	COG1024	Enoyl-CoA hydratase
GD442_RS22200	COG1309	transcriptional regulator
GD442_RS22205	COG0318	PFAM AMP-dependent synthetase and ligase
GD442_RS22230	COG2318	DinB family
GD442_RS22255	COG1131	(ABC) transporter
GD442_RS22260	COG2205	protein histidine kinase activity
GD442_RS22265	COG0745	RESPONSE REGULATOR receiver
GD442_RS22270	COG4895	conserved protein (DUF2196)
GD442_RS22275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GD442_RS22285	COG4509	Sortase family
GD442_RS22290	COG1120	ATPase activity
GD442_RS22305	COG5386	Cell surface protein
GD442_RS22315	COG5386	Cell surface protein
GD442_RS22320	COG1114	Component of the transport system for branched-chain amino acids
GD442_RS22325	COG1187	pseudouridine synthase activity
GD442_RS22335	COG1796	DNA polymerase
GD442_RS22335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GD442_RS22340	COG1286	toxin biosynthetic process
GD442_RS22385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GD442_RS22395	COG1418	mRNA catabolic process
GD442_RS22415	COG2814	Major facilitator Superfamily
GD442_RS22420	COG1566	PFAM secretion protein HlyD family protein
GD442_RS22425	COG1309	transcriptional regulator
GD442_RS22430	COG1363	Peptidase, m42
GD442_RS22455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GD442_RS22470	COG1484	DNA-dependent DNA replication
GD442_RS22475	COG3611	Membrane attachment protein
GD442_RS22485	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GD442_RS22490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GD442_RS22500	COG1971	Probably functions as a manganese efflux pump
GD442_RS22510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GD442_RS22510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GD442_RS22515	COG5002	protein histidine kinase activity
GD442_RS22520	COG0745	RESPONSE REGULATOR receiver
GD442_RS22535	COG0538	isocitrate dehydrogenase activity
GD442_RS22540	COG0372	Belongs to the citrate synthase family
GD442_RS22550	COG0628	permease
GD442_RS22555	COG3030	protein affecting phage T7 exclusion by the F plasmid
GD442_RS22580	COG1725	Transcriptional regulator
GD442_RS22585	COG0281	malic enzyme
GD442_RS22590	COG0587	DNA-directed DNA polymerase activity
GD442_RS22605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GD442_RS22620	COG4109	DRTGG domain
GD442_RS22630	COG0006	proline dipeptidase activity
GD442_RS22670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS22675	COG0662	Cupin 2, conserved barrel domain protein
GD442_RS22690	COG1028	Short-chain dehydrogenase reductase Sdr
GD442_RS22695	COG0589	response to stress
GD442_RS22700	COG0346	lactoylglutathione lyase activity
GD442_RS22740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS22765	COG0827	DNA restriction-modification system
GD442_RS22770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GD442_RS22775	COG3874	Sporulation protein YtfJ
GD442_RS22790	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GD442_RS22800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GD442_RS22815	COG1104	cysteine desulfurase activity
GD442_RS22825	COG0583	DNA-binding transcription factor activity
GD442_RS22830	COG0697	spore germination
GD442_RS22835	COG1309	transcriptional regulator
GD442_RS22840	COG1956	GAF domain-containing protein
GD442_RS22845	COG0626	cystathionine gamma-synthase activity
GD442_RS22870	COG0110	maltose O-acetyltransferase activity
GD442_RS22875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GD442_RS22880	COG0454	-acetyltransferase
GD442_RS22885	COG0517	IMP dehydrogenase activity
GD442_RS22890	COG0123	including yeast histone deacetylase and acetoin utilization protein
GD442_RS22905	COG0745	RESPONSE REGULATOR receiver
GD442_RS22915	COG0666	response to abiotic stimulus
GD442_RS22950	COG1609	Transcriptional regulator
GD442_RS22955	COG1605	Chorismate mutase
GD442_RS22955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GD442_RS22960	COG4851	CamS sex pheromone cAM373 precursor
GD442_RS22965	COG3118	belongs to the thioredoxin family
GD442_RS22975	COG2309	aminopeptidase activity
GD442_RS23000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS23015	COG1674	ftsk spoiiie
GD442_RS23020	COG0860	N-Acetylmuramoyl-L-alanine amidase
GD442_RS23020	COG1388	LysM domain
GD442_RS23030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GD442_RS23040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GD442_RS23045	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GD442_RS23050	COG1363	Peptidase, m42
GD442_RS23060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS23075	COG0510	thiamine kinase activity
GD442_RS23080	COG1523	belongs to the glycosyl hydrolase 13 family
GD442_RS23090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GD442_RS23095	COG1349	DNA-binding transcription factor activity
GD442_RS23100	COG1187	pseudouridine synthase activity
GD442_RS23105	COG2244	polysaccharide biosynthetic process
GD442_RS23110	COG2081	HI0933 family
GD442_RS23115	COG2814	Major facilitator Superfamily
GD442_RS23125	COG3832	glyoxalase III activity
GD442_RS23145	COG1329	Transcriptional regulator
GD442_RS23170	COG0314	molybdopterin synthase activity
GD442_RS23175	COG1763	Mo-molybdopterin cofactor biosynthetic process
GD442_RS23180	COG0303	'Molybdopterin
GD442_RS23190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GD442_RS23195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GD442_RS23215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GD442_RS23225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GD442_RS23265	COG2814	Major facilitator Superfamily
GD442_RS23270	COG0475	glutathione-regulated potassium exporter activity
GD442_RS23275	COG0490	domain, Protein
GD442_RS23280	COG0582	viral genome integration into host DNA
GD442_RS23290	COG1136	(ABC) transporter
GD442_RS23310	COG1242	4 iron, 4 sulfur cluster binding
GD442_RS23315	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GD442_RS23320	COG1794	racemase activity, acting on amino acids and derivatives
GD442_RS23340	COG2267	carboxylic ester hydrolase activity
GD442_RS23345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GD442_RS23350	COG0671	phosphoesterase, PA-phosphatase related
GD442_RS23355	COG0438	transferase activity, transferring glycosyl groups
GD442_RS23375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS23425	COG5002	protein histidine kinase activity
GD442_RS23430	COG3852	Histidine kinase
GD442_RS23445	COG2267	carboxylic ester hydrolase activity
GD442_RS23450	COG1368	sulfuric ester hydrolase activity
GD442_RS23470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GD442_RS23475	COG1116	anion transmembrane transporter activity
GD442_RS23480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GD442_RS23505	COG0494	nUDIX hydrolase
GD442_RS23545	COG0288	reversible hydration of carbon dioxide
GD442_RS23550	COG1271	oxidase subunit
GD442_RS23555	COG1294	oxidase, subunit
GD442_RS23570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS23590	COG1842	Phage shock protein A
GD442_RS23620	COG5002	protein histidine kinase activity
GD442_RS23625	COG0745	RESPONSE REGULATOR receiver
GD442_RS23655	COG1597	lipid kinase activity
GD442_RS23675	COG0577	efflux transmembrane transporter activity
GD442_RS23680	COG1136	(ABC) transporter
GD442_RS23695	COG0586	Pfam SNARE associated Golgi protein
GD442_RS23700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GD442_RS23705	COG0577	efflux transmembrane transporter activity
GD442_RS23710	COG1136	(ABC) transporter
GD442_RS23715	COG3708	Transcriptional regulator
GD442_RS23715	COG2207	Transcriptional regulator
GD442_RS23725	COG5658	integral membrane protein
GD442_RS23730	COG0640	Transcriptional regulator
GD442_RS23735	COG0745	RESPONSE REGULATOR receiver
GD442_RS23740	COG2205	protein histidine kinase activity
GD442_RS23745	COG0577	efflux transmembrane transporter activity
GD442_RS23750	COG0577	efflux transmembrane transporter activity
GD442_RS23755	COG1136	(ABC) transporter
GD442_RS23760	COG0577	efflux transmembrane transporter activity
GD442_RS23805	COG3964	amidohydrolase
GD442_RS23825	COG4948	Mandelate Racemase Muconate Lactonizing
GD442_RS23835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GD442_RS23840	COG0596	Alpha beta hydrolase
GD442_RS23850	COG1169	isochorismate synthase
GD442_RS23855	COG1575	Belongs to the MenA family. Type 1 subfamily
GD442_RS23860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GD442_RS23865	COG1278	Cold shock
GD442_RS23880	COG0058	SHG alpha-glucan phosphorylase activity
GD442_RS23890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GD442_RS23910	COG1404	Belongs to the peptidase S8 family
GD442_RS23915	COG0039	L-malate dehydrogenase activity
GD442_RS24010	COG0544	peptidyl-prolyl cis-trans isomerase activity
GD442_RS24045	COG1285	pathogenesis
GD442_RS24050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GD442_RS24065	COG2155	Conserved Protein
GD442_RS24070	COG1098	S1 RNA binding domain
GD442_RS24075	COG0436	Aminotransferase
GD442_RS24080	COG1522	sequence-specific DNA binding
GD442_RS24085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GD442_RS24090	COG2267	carboxylic ester hydrolase activity
GD442_RS24100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GD442_RS24115	COG5018	Exonuclease
GD442_RS24120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GD442_RS24135	COG0423	glycine-tRNA ligase activity
GD442_RS24140	COG2050	protein possibly involved in aromatic compounds catabolism
GD442_RS24150	COG1268	BioY protein
GD442_RS24155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GD442_RS24160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GD442_RS24175	COG3584	3D domain protein
GD442_RS24190	COG1252	NADH dehydrogenase
GD442_RS24205	COG3708	Transcriptional regulator
GD442_RS24220	COG1683	Conserved Protein
GD442_RS24240	COG0316	Belongs to the HesB IscA family
GD442_RS24255	COG1252	NADH dehydrogenase
GD442_RS24270	COG0390	transport system, permease component
GD442_RS24275	COG2824	Alkylphosphonate utilization operon protein PhnA
GD442_RS24300	COG4837	Protein of unknown function (DUF1462)
GD442_RS24305	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GD442_RS24315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GD442_RS24320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GD442_RS24340	COG1358	cellular component organization or biogenesis
GD442_RS24350	COG2249	NAD(P)H dehydrogenase (quinone) activity
GD442_RS24355	COG0647	UMP catabolic process
GD442_RS24365	COG2445	Protein of unknown function DUF86
GD442_RS24370	COG1494	fructose-1,6-bisphosphatase
GD442_RS24385	COG4470	Protein conserved in bacteria
GD442_RS24395	COG0789	Transcriptional regulator
GD442_RS24400	COG4377	Putative membrane peptidase family (DUF2324)
GD442_RS24425	COG0739	heme binding
GD442_RS24435	COG3377	Domain of unknown function (DUF1805)
GD442_RS24440	COG0737	Belongs to the 5'-nucleotidase family
GD442_RS24445	COG0719	Fe-S assembly protein
GD442_RS24450	COG0822	iron-sulfur transferase activity
GD442_RS24455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GD442_RS24460	COG0719	Fe-S assembly protein
GD442_RS24465	COG0396	ATPase activity
GD442_RS24470	COG1464	Belongs to the NlpA lipoprotein family
GD442_RS24475	COG1464	Belongs to the NlpA lipoprotein family
GD442_RS24480	COG2011	ABC-type metal ion transport system permease component
GD442_RS24485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GD442_RS24495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GD442_RS24500	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GD442_RS24510	COG1393	Belongs to the ArsC family
GD442_RS24550	COG1309	transcriptional regulator
GD442_RS24555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GD442_RS24560	COG1960	acyl-CoA dehydrogenase activity
GD442_RS24565	COG0183	Belongs to the thiolase family
GD442_RS24570	COG1024	Enoyl-CoA hydratase
GD442_RS24570	COG1250	3-hydroxyacyl-CoA dehydrogenase
GD442_RS24580	COG1686	Belongs to the peptidase S11 family
GD442_RS24595	COG0011	TIGRFAM Protein of
GD442_RS24600	COG0840	transmembrane signaling receptor activity
GD442_RS24620	COG2814	Major facilitator Superfamily
GD442_RS24625	COG0531	amino acid
GD442_RS24650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GD442_RS24685	COG0586	Pfam SNARE associated Golgi protein
GD442_RS24695	COG1376	ErfK ybiS ycfS ynhG family protein
GD442_RS24700	COG0745	RESPONSE REGULATOR receiver
GD442_RS24705	COG5002	protein histidine kinase activity
GD442_RS24735	COG0840	transmembrane signaling receptor activity
GD442_RS24740	COG2151	metal-sulfur cluster biosynthetic enzyme
GD442_RS24745	COG3227	Zinc metalloprotease (Elastase)
GD442_RS24750	COG1741	Belongs to the pirin family
GD442_RS24765	COG0586	Pfam SNARE associated Golgi protein
GD442_RS24770	COG0475	glutathione-regulated potassium exporter activity
GD442_RS24775	COG0490	domain, Protein
GD442_RS24780	COG1115	amino acid carrier protein
GD442_RS24785	COG0783	Belongs to the Dps family
GD442_RS24800	COG1611	Belongs to the LOG family
GD442_RS24810	COG1528	Iron-storage protein
GD442_RS24820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GD442_RS24825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GD442_RS24830	COG1115	amino acid carrier protein
GD442_RS24835	COG1115	amino acid carrier protein
GD442_RS24840	COG2910	NAD(P)H-binding
GD442_RS24855	COG0656	L-ascorbic acid biosynthetic process
GD442_RS24860	COG2814	Major facilitator Superfamily
GD442_RS24865	COG1733	regulation of RNA biosynthetic process
GD442_RS24875	COG1252	NADH dehydrogenase
GD442_RS24880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GD442_RS24930	COG0488	(ABC) transporter
GD442_RS24935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GD442_RS24940	COG3223	Belongs to the PsiE family
GD442_RS25010	COG1309	transcriptional regulator
GD442_RS25025	COG0557	exoribonuclease II activity
GD442_RS25030	COG1647	Serine aminopeptidase, S33
GD442_RS25035	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GD442_RS25040	COG1346	cytolysis
GD442_RS25075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GD442_RS25090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GD442_RS25115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GD442_RS25130	COG2323	membrane
GD442_RS25140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GD442_RS25150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GD442_RS25160	COG1051	belongs to the nudix hydrolase family
GD442_RS25170	COG0492	ferredoxin-NADP+ reductase activity
GD442_RS25175	COG0457	Tetratricopeptide repeat
GD442_RS25180	COG0110	maltose O-acetyltransferase activity
GD442_RS25200	COG1950	PFAM Membrane protein of
GD442_RS25205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GD442_RS25210	COG0556	nucleotide-excision repair
GD442_RS25225	COG0789	Transcriptional regulator
GD442_RS25245	COG0583	DNA-binding transcription factor activity
GD442_RS25255	COG0655	NAD(P)H dehydrogenase (quinone) activity
GD442_RS25260	COG0488	(ABC) transporter
GD442_RS25270	COG1132	(ABC) transporter
GD442_RS25280	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GD442_RS25285	COG0583	DNA-binding transcription factor activity
GD442_RS25290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GD442_RS25295	COG0793	Belongs to the peptidase S41A family
GD442_RS25295	COG3409	Peptidoglycan-binding domain 1 protein
GD442_RS25300	COG2177	Part of the ABC transporter FtsEX involved in
GD442_RS25305	COG2884	Cell division ATP-binding protein ftsE
GD442_RS25325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GD442_RS25330	COG1278	Cold shock
GD442_RS25335	COG1040	competence protein
GD442_RS25340	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GD442_RS25345	COG0791	NLP P60 protein
GD442_RS25350	COG1733	regulation of RNA biosynthetic process
GD442_RS25355	COG1307	EDD domain protein, DegV family
GD442_RS25360	COG1739	Uncharacterized protein family UPF0029
GD442_RS25365	COG1316	TRANSCRIPTIONal
GD442_RS25370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GD442_RS25375	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GD442_RS25380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GD442_RS25390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GD442_RS25390	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GD442_RS25410	COG1486	melibiose metabolic process
GD442_RS25415	COG1447	Phosphotransferase system cellobiose-specific component IIA
GD442_RS25420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GD442_RS25440	COG1447	Phosphotransferase system cellobiose-specific component IIA
GD442_RS25450	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GD442_RS25455	COG1301	dicarboxylic acid transport
GD442_RS25470	COG1511	domain protein
GD442_RS25475	COG0583	DNA-binding transcription factor activity
GD442_RS25480	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GD442_RS25485	COG1271	oxidase subunit
GD442_RS25490	COG1294	oxidase, subunit
GD442_RS25495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GD442_RS25505	COG1620	l-lactate permease
GD442_RS25515	COG2389	metal-binding protein
GD442_RS25525	COG1368	sulfuric ester hydrolase activity
GD442_RS25535	COG0791	NLP P60 protein
GD442_RS25535	COG1388	LysM domain
GD442_RS25540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GD442_RS25550	COG1215	transferase activity, transferring glycosyl groups
GD442_RS25555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GD442_RS25560	COG1388	LysM domain
GD442_RS25560	COG3584	3D domain protein
GD442_RS25585	COG4715	Zinc finger, swim domain protein
GD442_RS25590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GD442_RS25620	COG1191	sigma factor activity
GD442_RS25630	COG0577	efflux transmembrane transporter activity
GD442_RS25635	COG1136	(ABC) transporter
GD442_RS25645	COG2271	Major facilitator Superfamily
GD442_RS25660	COG5002	protein histidine kinase activity
GD442_RS25665	COG0745	RESPONSE REGULATOR receiver
GD442_RS25670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GD442_RS25685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GD442_RS25695	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GD442_RS25700	COG5434	Belongs to the glycosyl hydrolase 28 family
GD442_RS25705	COG0728	peptidoglycan biosynthetic process
GD442_RS25725	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GD442_RS25730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GD442_RS25735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GD442_RS25740	COG4464	protein tyrosine phosphatase activity
GD442_RS25745	COG0489	protein tyrosine kinase activity
GD442_RS25750	COG3944	biosynthesis protein
GD442_RS25755	COG0489	protein tyrosine kinase activity
GD442_RS25770	COG1609	Transcriptional regulator
GD442_RS25780	COG0739	heme binding
GD442_RS25795	COG3279	Response regulator of the LytR AlgR family
GD442_RS25800	COG2385	sporulation resulting in formation of a cellular spore
GD442_RS25815	COG4836	Membrane
GD442_RS25820	COG1007	ATP synthesis coupled electron transport
GD442_RS25825	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GD442_RS25830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GD442_RS25840	COG0839	Belongs to the complex I subunit 6 family
GD442_RS25860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GD442_RS25875	COG3300	MHYT domain
GD442_RS25875	COG5001	Diguanylate cyclase
GD442_RS25925	COG0356	it plays a direct role in the translocation of protons across the membrane
GD442_RS25960	COG0698	ribose 5-phosphate isomerase
GD442_RS25975	COG2259	Doxx family
GD442_RS25980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GD442_RS25995	COG0009	L-threonylcarbamoyladenylate synthase
GD442_RS26030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GD442_RS26035	COG1494	fructose-1,6-bisphosphatase
GD442_RS26055	COG4821	SIS domain
GD442_RS26075	COG1960	acyl-CoA dehydrogenase activity
GD442_RS26080	COG1960	acyl-CoA dehydrogenase activity
GD442_RS26085	COG1250	3-hydroxyacyl-CoA dehydrogenase
GD442_RS26090	COG0183	Belongs to the thiolase family
GD442_RS26095	COG0247	lactate metabolic process
GD442_RS26095	COG2181	nitrate reductase activity
GD442_RS26100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GD442_RS26110	COG3300	MHYT domain
GD442_RS26110	COG5001	Diguanylate cyclase
GD442_RS26125	COG3227	Zinc metalloprotease (Elastase)
GD442_RS26130	COG2197	response regulator
GD442_RS26135	COG4585	Histidine kinase
GD442_RS26140	COG0842	Transport permease protein
GD442_RS26145	COG1131	(ABC) transporter
GD442_RS26150	COG0024	Methionine aminopeptidase
GD442_RS26160	COG2234	aminopeptidase activity
GD442_RS26185	COG4506	Protein conserved in bacteria
GD442_RS26190	COG1619	proteins homologs of microcin C7 resistance protein MccF
GD442_RS26210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GD442_RS26215	COG2814	Major facilitator Superfamily
GD442_RS26220	COG0789	Transcriptional regulator
GD442_RS26225	COG0584	glycerophosphoryl diester phosphodiesterase
GD442_RS26230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GD442_RS26240	COG1994	Peptidase M50
GD442_RS26250	COG1078	dGTPase activity
GD442_RS26255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GD442_RS26260	COG1120	ATPase activity
GD442_RS26265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS26270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GD442_RS26290	COG0280	phosphate acetyltransferase
GD442_RS26305	COG3773	Cell wall hydrolase
GD442_RS26315	COG2363	Small membrane protein
GD442_RS26325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GD442_RS26330	COG2233	PERMEase
GD442_RS26335	COG0561	phosphatase activity
GD442_RS26340	COG2814	Major facilitator Superfamily
GD442_RS26350	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GD442_RS26355	COG1131	(ABC) transporter
GD442_RS26360	COG2755	lipolytic protein G-D-S-L family
GD442_RS26365	COG1609	Transcriptional regulator
GD442_RS26375	COG0460	homoserine dehydrogenase
GD442_RS26395	COG1011	Hydrolase
GD442_RS26400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GD442_RS26410	COG2197	response regulator
GD442_RS26415	COG4585	Histidine kinase
GD442_RS26415	COG2203	Gaf domain
GD442_RS26420	COG0351	phosphomethylpyrimidine kinase
GD442_RS26425	COG3706	GGDEF domain
GD442_RS26430	COG2879	small protein
GD442_RS26435	COG1966	Carbon starvation protein
GD442_RS26440	COG3279	Response regulator of the LytR AlgR family
GD442_RS26445	COG0477	Major facilitator Superfamily
GD442_RS26455	COG0438	transferase activity, transferring glycosyl groups
GD442_RS26470	COG0840	transmembrane signaling receptor activity
GD442_RS26480	COG1607	acyl-coa hydrolase
GD442_RS26485	COG1216	Glycosyl transferase, family 2
GD442_RS26500	COG1216	Glycosyl transferase, family 2
GD442_RS26510	COG4485	Bacterial membrane protein, YfhO
GD442_RS26515	COG0463	Glycosyl transferase, family 2
GD442_RS26520	COG0488	(ABC) transporter
GD442_RS26525	COG1309	transcriptional regulator
GD442_RS26530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GD442_RS26535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GD442_RS26535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GD442_RS26540	COG0628	permease
GD442_RS26560	COG3275	phosphorelay sensor kinase activity
GD442_RS26565	COG2814	Major facilitator Superfamily
GD442_RS26570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GD442_RS26575	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GD442_RS26595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GD442_RS26600	COG1272	protein, Hemolysin III
GD442_RS26620	COG1164	Oligoendopeptidase f
GD442_RS26630	COG5002	protein histidine kinase activity
GD442_RS26645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GD442_RS26650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GD442_RS26655	COG4853	Protein conserved in bacteria
GD442_RS26665	COG5002	protein histidine kinase activity
GD442_RS26670	COG0745	RESPONSE REGULATOR receiver
GD442_RS26700	COG0305	Participates in initiation and elongation during chromosome replication
GD442_RS26710	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GD442_RS26715	COG4241	membrane
GD442_RS26735	COG0012	GTP binding
GD442_RS26740	COG4481	Protein conserved in bacteria
GD442_RS26745	COG0668	transmembrane transport
GD442_RS26755	COG1475	DNA binding
GD442_RS26760	COG1192	Involved in chromosome partitioning
GD442_RS26785	COG1847	R3H domain protein
GD442_RS26790	COG0706	membrane insertase activity
GD442_RS26895	COG0457	Tetratricopeptide repeat
GD442_RS26930	COG1192	Involved in chromosome partitioning
GD442_RS26950	COG0551	DNA topoisomerase type I activity
GD442_RS26950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GD442_RS26980	COG0791	NLP P60 protein
GD442_RS26980	COG0741	lytic transglycosylase activity
GD442_RS27100	COG0156	8-amino-7-oxononanoate synthase activity
GD442_RS27110	COG1760	l-serine dehydratase
GD442_RS27275	COG0456	acetyltransferase
GD442_RS27285	COG5632	N-Acetylmuramoyl-L-alanine amidase
GD442_RS27285	COG3409	Peptidoglycan-binding domain 1 protein
GD442_RS27290	COG1522	sequence-specific DNA binding
GD442_RS27300	COG0791	NLP P60 protein
GD442_RS27300	COG1388	LysM domain
GD442_RS27300	COG3103	Sh3 type 3 domain protein
GD442_RS27320	COG4166	transmembrane transport
GD442_RS27345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GD442_RS27455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GD442_RS27455	COG0551	DNA topoisomerase type I activity
GD442_RS27515	COG0791	NLP P60 protein
GD442_RS27515	COG0741	lytic transglycosylase activity