locus-tag class description GNE05_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GNE05_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GNE05_RS00015 ENOG410848D S4 domain protein YaaA GNE05_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GNE05_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GNE05_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GNE05_RS00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GNE05_RS00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GNE05_RS00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GNE05_RS00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GNE05_RS00095 ENOG4105BZW Glycerate kinase GNE05_RS00105 ENOG4105ZMH deoxynucleoside kinase GNE05_RS00115 ENOG4105VRS hydrolase family 18 GNE05_RS00120 ENOG4105GTG Isochorismatase GNE05_RS00125 ENOG4108Z6B deaminase GNE05_RS00135 ENOG4105C6E dna polymerase iii GNE05_RS00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GNE05_RS00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GNE05_RS00155 ENOG41067KS pro-sigma K processing GNE05_RS00195 ENOG4105CDW Resistance protein GNE05_RS00200 ENOG4105CXN decarboxylase GNE05_RS00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GNE05_RS00210 ENOG4105X0R protein from nitrogen regulatory protein P-II GNE05_RS00215 ENOG4105XVJ Protein of unknown function (DUF327) GNE05_RS00220 ENOG4105FA2 dna polymerase iii GNE05_RS00225 ENOG4105MA4 psp1 domain protein GNE05_RS00235 ENOG41060K3 Methyltransferase GNE05_RS00240 ENOG4105VC4 domain protein GNE05_RS00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GNE05_RS00250 ENOG4105KRN Transcriptional regulator, abrb family GNE05_RS00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GNE05_RS00260 ENOG4105F8V Hydrolase, tatD family GNE05_RS00265 ENOG41069ER domain protein GNE05_RS00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GNE05_RS00280 ENOG4105XFA sporulation peptidase YabG GNE05_RS00285 ENOG4105W42 Veg protein GNE05_RS00290 ENOG4105XEW small acid-soluble spore protein GNE05_RS00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GNE05_RS00300 ENOG4105DFT pur operon repressor GNE05_RS00305 ENOG4105KME endoribonuclease L-psp GNE05_RS00310 ENOG4105K4W Could be involved in septation (By similarity) GNE05_RS00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GNE05_RS00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GNE05_RS00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GNE05_RS00340 ENOG4108JA2 transcriptioN-repair coupling factor GNE05_RS00345 ENOG4108M14 stage v sporulation protein t GNE05_RS00355 ENOG4108IY2 MazG family GNE05_RS00360 ENOG41082I2 s4 domain protein GNE05_RS00365 ENOG4105VYY sporulation protein yabp GNE05_RS00380 ENOG41060GV RNA binding s1 domain protein GNE05_RS00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GNE05_RS00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase GNE05_RS00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GNE05_RS00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) GNE05_RS00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GNE05_RS00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase GNE05_RS00440 ENOG4105C6T cysteine synthase GNE05_RS00445 ENOG4105CRQ synthase (Component I) GNE05_RS00450 ENOG4105DDQ anthranilate synthase GNE05_RS00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GNE05_RS00460 ENOG4105EEI dihydropteroate synthase GNE05_RS00465 ENOG4105KRF dihydroneopterin aldolase GNE05_RS00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GNE05_RS00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GNE05_RS00485 ENOG4105CRK lysyL-tRNA synthetase GNE05_RS00570 ENOG4108Z0C Uvrb UvrC protein GNE05_RS00575 ENOG41066A3 ATP guanido phosphotransferase GNE05_RS00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GNE05_RS00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GNE05_RS00595 ENOG4105CTP PilT protein domain protein GNE05_RS00600 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GNE05_RS00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GNE05_RS00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GNE05_RS00615 ENOG4105D7W serine acetyltransferase GNE05_RS00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) GNE05_RS00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 GNE05_RS00635 ENOG4105M0M Tetracycline resistance protein GNE05_RS00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GNE05_RS00660 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GNE05_RS00670 ENOG4108VZM 50s ribosomal protein L10 GNE05_RS00675 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GNE05_RS00680 ENOG4107Y49 methyltransferase GNE05_RS00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GNE05_RS00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GNE05_RS00695 ENOG4105XPM ribosomal protein GNE05_RS00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GNE05_RS00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GNE05_RS00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GNE05_RS00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GNE05_RS00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase GNE05_RS00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GNE05_RS00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GNE05_RS00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GNE05_RS00740 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GNE05_RS00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GNE05_RS00750 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GNE05_RS00755 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GNE05_RS00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GNE05_RS00765 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GNE05_RS00770 ENOG41082SA 50s ribosomal protein l29 GNE05_RS00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GNE05_RS00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GNE05_RS00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GNE05_RS00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GNE05_RS00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GNE05_RS00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GNE05_RS00820 ENOG4105VPB 50S ribosomal protein L30 GNE05_RS00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GNE05_RS00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GNE05_RS00835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GNE05_RS00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GNE05_RS00850 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GNE05_RS00860 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GNE05_RS00865 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GNE05_RS00870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GNE05_RS00875 ENOG4108ZT0 50S ribosomal protein l17 GNE05_RS00880 ENOG4108JJB ABC transporter GNE05_RS00885 ENOG4108JJB ABC transporter GNE05_RS00890 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GNE05_RS00895 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GNE05_RS00900 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GNE05_RS00905 ENOG4108UJD 30S ribosomal protein S9 GNE05_RS00910 ENOG4108I0C methyltransferase GNE05_RS00930 ENOG4105D1F ATP-binding protein GNE05_RS00945 ENOG4108NMV polysaccharide deacetylase GNE05_RS00980 ENOG410635T phage-like element pbsx protein GNE05_RS00990 ENOG41067QW Transcriptional regulator GNE05_RS01055 ENOG4105CDU Replicative dna helicase GNE05_RS01065 ENOG4105QBX endodeoxyribonuclease RusA GNE05_RS01160 ENOG4105IG6 Phage terminase, large subunit GNE05_RS01165 ENOG4108MDF Phage Portal Protein GNE05_RS01170 ENOG4106CGH Phage Mu protein F like protein GNE05_RS01205 ENOG41060SN GNE05_RS01220 ENOG4105PQS phage protein GNE05_RS01225 ENOG4105FR7 XkdM protein, phage-like element PBSX GNE05_RS01235 ENOG4105MTC XkdN-like protein GNE05_RS01240 ENOG4108FKH Transglycosylase SLT domain GNE05_RS01245 ENOG4108WZM domain protein GNE05_RS01250 ENOG4105X7F GNE05_RS01260 ENOG4105MFU Protein of unknown function (DUF2634) GNE05_RS01265 ENOG41066EA baseplate J family protein GNE05_RS01270 ENOG410906S phage-like element pbsx protein xkdt GNE05_RS01365 ENOG4108JPW Aminotransferase GNE05_RS01380 ENOG4105CHH sulfate transporter GNE05_RS01390 ENOG4108SA1 esterase GNE05_RS01410 ENOG410874W AraC family transcriptional regulator GNE05_RS01415 ENOG4105EHZ conserved protein UCP016719 GNE05_RS01420 ENOG4105D17 glycoside hydrolase, family 3 domain protein GNE05_RS01435 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GNE05_RS01445 ENOG4105EWC Purine nucleoside phosphorylase GNE05_RS01475 ENOG4105EMN RNA polymerase sigma factor GNE05_RS01485 ENOG4105C8B TIGR00159 family GNE05_RS01490 ENOG4107U5W ybbr family GNE05_RS01495 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GNE05_RS01530 ENOG4106K80 GNE05_RS01540 ENOG41067MG lrgb family GNE05_RS01550 ENOG41061AU MarR family Transcriptional regulator GNE05_RS01565 ENOG4105BZU Histidine kinase GNE05_RS01570 ENOG4105WH1 Two component transcriptional regulator luxr family GNE05_RS01575 ENOG4105CJ1 ABC, transporter GNE05_RS01600 ENOG4106DDH Sporulation-specific SASP protein GNE05_RS01615 ENOG4107QTZ amino acid GNE05_RS01640 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GNE05_RS01645 ENOG4105CXY transporter GNE05_RS01680 ENOG4107SCQ Iron-containing alcohol dehydrogenase GNE05_RS01685 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GNE05_RS01690 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GNE05_RS01695 ENOG4107ZTW SNARE associated Golgi GNE05_RS01710 ENOG4105C72 UPF0176 protein GNE05_RS01720 ENOG4105CM2 brancheD-chain amino acid aminotransferase GNE05_RS01725 ENOG4108IQI permease GNE05_RS01730 ENOG4108J5H Homocysteine s-methyltransferase GNE05_RS01740 ENOG4105CSV Glutaminase GNE05_RS01775 ENOG4105DGI Alkaline phosphatase GNE05_RS01780 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GNE05_RS01785 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GNE05_RS01790 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GNE05_RS01795 ENOG4107EPV Aminotransferase class V GNE05_RS01800 ENOG4105C0R drug resistance transporter emrb qaca subfamily GNE05_RS01805 ENOG4105J7D transcriptional regulator GNE05_RS01810 ENOG4107RB3 L-asparaginase GNE05_RS01815 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold GNE05_RS01820 ENOG41060AI SEC-C motif GNE05_RS01825 ENOG4107SET aldo keto reductase GNE05_RS01855 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GNE05_RS01865 ENOG4105DSE periplasmic solute binding protein GNE05_RS01870 ENOG4105DIK (ABC) transporter GNE05_RS01880 ENOG4105DEN Luciferase family GNE05_RS01885 ENOG4108N0M stress protein GNE05_RS01890 ENOG4106FN3 tellurium resistance protein GNE05_RS01895 ENOG4106FN3 tellurium resistance protein GNE05_RS01900 ENOG4107TS3 membrane protein, TerC GNE05_RS01905 ENOG4108TTB tellurium resistance protein GNE05_RS01915 ENOG41079KZ Major Facilitator Superfamily GNE05_RS01920 ENOG4108IJ7 Glycine betaine GNE05_RS01925 ENOG4107SQ8 Glycine betaine GNE05_RS01955 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GNE05_RS01985 ENOG4105EIG urea carboxylase-associated protein 1 GNE05_RS01990 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GNE05_RS02000 ENOG4105I1F Resistance protein GNE05_RS02005 ENOG4108WBH protein TIM barrel GNE05_RS02010 ENOG4105DJB Major Facilitator Superfamily GNE05_RS02015 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GNE05_RS02020 ENOG4105I82 acetyl xylan esterase GNE05_RS02025 ENOG410756H nucleotidyltransferase GNE05_RS02035 ENOG4105C26 Dehydrogenase GNE05_RS02040 ENOG4105CK7 Sodium proline symporter GNE05_RS02045 ENOG4107YHD transcriptional regulator GNE05_RS02050 ENOG4105CAY ferredoxin--nadp reductase GNE05_RS02055 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GNE05_RS02060 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GNE05_RS02065 ENOG4108IFG nitrite reductase, (NAD(P)H) GNE05_RS02070 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GNE05_RS02085 ENOG4105CKI cobalamin synthesis protein GNE05_RS02090 ENOG4105E2A Dehydrogenase GNE05_RS02095 ENOG4105HHM rdd domain containing protein GNE05_RS02105 ENOG4105CS2 ec 3.2.1.21 GNE05_RS02120 ENOG41080HJ 6-phospho 3-hexuloisomerase GNE05_RS02125 ENOG4108VA3 3-hexulose-6-phosphate synthase GNE05_RS02130 ENOG4105KVH Transcriptional regulator GNE05_RS02135 ENOG4105CEY Amp-dependent synthetase and ligase GNE05_RS02170 ENOG4105CDA abc transporter atp-binding protein GNE05_RS02175 ENOG4105DRP amino acid AbC transporter GNE05_RS02185 ENOG4106P55 Transcriptional regulator GNE05_RS02190 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GNE05_RS02195 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GNE05_RS02200 ENOG41069ZX GNE05_RS02205 ENOG41069ZX GNE05_RS02210 ENOG4105DUX Transporter GNE05_RS02225 ENOG4105E1K spore germination protein GNE05_RS02240 ENOG4105CPU Monooxygenase GNE05_RS02245 ENOG4108XSB acetyltransferase, (GNAT) family GNE05_RS02250 ENOG4105EAB amino acid AbC transporter GNE05_RS02255 ENOG4108HW4 amino acid AbC transporter GNE05_RS02265 ENOG4105CH2 amidohydrolase GNE05_RS02270 ENOG4108PGP mmge prpd family protein GNE05_RS02280 ENOG4107WD8 ABC transporter, permease GNE05_RS02285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE05_RS02290 ENOG4105BZU Histidine kinase GNE05_RS02310 ENOG4105CFH Aspartokinase GNE05_RS02315 ENOG4105DHS permease protein GNE05_RS02320 ENOG4105CM4 permease protein GNE05_RS02325 ENOG4108IPW abc transporter atp-binding protein GNE05_RS02340 ENOG4105R8C Transcriptional regulator GNE05_RS02345 ENOG4108DBC nitroreductase GNE05_RS02350 ENOG41067V3 Antibiotic biosynthesis monooxygenase GNE05_RS02355 ENOG4105YVS arsR family transcriptional regulator GNE05_RS02365 ENOG4108JPW Aminotransferase GNE05_RS02370 ENOG4105C26 Dehydrogenase GNE05_RS02380 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GNE05_RS02385 ENOG4105KTB nuclear export factor GLE1 GNE05_RS02390 ENOG4108T5E Copper resistance protein GNE05_RS02395 ENOG4108ZYE Transcriptional regulator GNE05_RS02415 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GNE05_RS02435 ENOG4105E7W lamb ycsf family protein GNE05_RS02440 ENOG4105C5A transporter GNE05_RS02445 ENOG4105CFM UPF0317 protein GNE05_RS02450 ENOG4105P4J Allophanate hydrolase, subunit 1 GNE05_RS02460 ENOG4107258 Transcriptional regulator GNE05_RS02465 ENOG4105XJB lipolytic protein G-D-S-L family GNE05_RS02475 ENOG41061CK Antibiotic biosynthesis monooxygenase GNE05_RS02480 ENOG4107RVG penicillin-binding protein GNE05_RS02485 ENOG4107QM2 Aldo Keto reductase GNE05_RS02490 ENOG4105ETD TRANSCRIPTIONal GNE05_RS02500 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GNE05_RS02515 ENOG410606W general stress protein GNE05_RS02525 ENOG4105VCH membrane GNE05_RS02535 ENOG4105C9U ATP-dependent DNA helicase RecQ GNE05_RS02550 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GNE05_RS02555 ENOG4107R8N Glycosyl transferase, family 2 GNE05_RS02565 ENOG4105C0X amino acid GNE05_RS02630 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GNE05_RS02640 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) GNE05_RS02645 ENOG4105RXJ GNE05_RS02650 ENOG4105KPY Small multidrug resistance protein GNE05_RS02655 ENOG4105EU9 GNE05_RS02665 ENOG41082W1 Cupin 2, conserved barrel domain protein GNE05_RS02680 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GNE05_RS02685 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GNE05_RS02690 ENOG4108MRH transcriptional regulatory protein GNE05_RS02695 ENOG4107QJT sodium dicarboxylate symporter GNE05_RS02700 ENOG4106F5Q Membrane GNE05_RS02705 ENOG4105CJ1 ABC, transporter GNE05_RS02720 ENOG4105FDT acyl-CoA dehydrogenase GNE05_RS02740 ENOG4105SZ6 Thioredoxin GNE05_RS02745 ENOG4105CPF Cell wall formation (By similarity) GNE05_RS02750 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GNE05_RS02755 ENOG4105C1J atp-dependent rna helicase GNE05_RS02760 ENOG410905X membrane-flanked domain protein GNE05_RS02765 ENOG4105CKV Membrane GNE05_RS02775 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GNE05_RS02780 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GNE05_RS02785 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GNE05_RS02795 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GNE05_RS02800 ENOG4107MMM Anti-sigma-factor antagonist GNE05_RS02805 ENOG4105FUA antagonist GNE05_RS02810 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GNE05_RS02815 ENOG4107SGM protein serine threonine phosphatase GNE05_RS02820 ENOG4105WN5 stage II sporulation protein GNE05_RS02825 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GNE05_RS02835 ENOG41064BQ Phosphatase GNE05_RS02850 ENOG410906U SprT-like GNE05_RS02895 ENOG4105C94 Transporter GNE05_RS02900 ENOG4105CSH Transporter GNE05_RS02920 ENOG4108ZMQ domain protein GNE05_RS02935 ENOG4108Z40 Transcriptional regulator GNE05_RS02940 ENOG4108RYK Nad-dependent epimerase dehydratase GNE05_RS02945 ENOG4105ECK Fatty Acid Desaturase GNE05_RS02955 ENOG4105VEQ Cold shock protein GNE05_RS02960 ENOG4108VJ1 Transcriptional regulator (CarD family GNE05_RS02965 ENOG4105XTG Pfam:DUF156 GNE05_RS02970 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GNE05_RS02975 ENOG4105C72 UPF0176 protein GNE05_RS02980 ENOG4105VFE sira family GNE05_RS02985 ENOG4107TPS domain protein GNE05_RS02990 ENOG4105VFE sira family GNE05_RS02995 ENOG41087NI Sulfite exporter TauE/SafE GNE05_RS03015 ENOG4105IRW patatin-like phospholipase family protein GNE05_RS03025 ENOG4107RCH Diaminopropionate ammonia-lyase GNE05_RS03035 ENOG4105KME endoribonuclease L-psp GNE05_RS03040 ENOG4105C44 Serine transporter GNE05_RS03045 ENOG4105CH2 amidohydrolase GNE05_RS03050 ENOG4108MCI Transcriptional regulator, ARAC family GNE05_RS03055 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GNE05_RS03060 ENOG4107U9B transcriptional regulator GNE05_RS03065 ENOG4105DXI Major Facilitator superfamily GNE05_RS03085 ENOG4105DNP FAD linked oxidase domain protein GNE05_RS03090 ENOG4105PGM cation diffusion facilitator family transporter GNE05_RS03095 ENOG4105H3G oxidoreductase GNE05_RS03135 ENOG4105DWF phosphomethylpyrimidine kinase GNE05_RS03150 ENOG4105DQ4 alcohol dehydrogenase GNE05_RS03155 ENOG4105VUF Transcriptional regulator GNE05_RS03165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNE05_RS03180 ENOG4105EQ0 Major Facilitator superfamily GNE05_RS03185 ENOG4108JGH Tetr family transcriptional regulator GNE05_RS03190 ENOG4105T38 integral membrane protein GNE05_RS03195 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNE05_RS03210 ENOG4105E2A Dehydrogenase GNE05_RS03215 ENOG4105PGS Spore coat protein GNE05_RS03225 ENOG4106UW1 Major Facilitator superfamily GNE05_RS03245 ENOG4105ENE Histidine kinase GNE05_RS03250 ENOG4108VB1 regulatoR GNE05_RS03255 ENOG4105EYF MMPL domain protein GNE05_RS03275 ENOG4108JYZ YitT family GNE05_RS03285 ENOG4105C2C drug resistance transporter, Bcr CflA GNE05_RS03290 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GNE05_RS03310 ENOG41090E6 transcriptional regulator MERR family GNE05_RS03325 ENOG4105F2W methyltransferase GNE05_RS03330 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GNE05_RS03335 ENOG4105DRR Transcriptional regulator, GntR family GNE05_RS03355 ENOG4105FQP Beta-lactamase GNE05_RS03360 ENOG41090UD (LipO)protein GNE05_RS03365 ENOG4108SUT Major Facilitator Superfamily GNE05_RS03370 ENOG4108TZY GntR Family Transcriptional Regulator GNE05_RS03375 ENOG4105JXH GntR family transcriptional regulator GNE05_RS03380 ENOG4105DJ2 Major Facilitator Superfamily GNE05_RS03400 ENOG4107QTZ amino acid GNE05_RS03420 ENOG4107QNK )-transporter GNE05_RS03460 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GNE05_RS03465 ENOG4105K8N protein family UPF0079, ATPase GNE05_RS03470 ENOG41072GX Peptidase M22 Glycoprotease GNE05_RS03475 ENOG410801F ribosomal-protein-alanine acetyltransferase GNE05_RS03480 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GNE05_RS03485 ENOG4105C5H ABC transporter GNE05_RS03490 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GNE05_RS03495 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GNE05_RS03500 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GNE05_RS03505 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GNE05_RS03515 ENOG4108TYN CAAX amino terminal protease family protein GNE05_RS03520 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GNE05_RS03525 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GNE05_RS03575 ENOG4108M15 ABC transporter GNE05_RS03580 ENOG4105KCT ABC transporter GNE05_RS03585 ENOG4105PGZ NB-ARC domain GNE05_RS03590 ENOG4105CPQ Dehydrogenase GNE05_RS03595 ENOG4105CT4 transporter GNE05_RS03610 ENOG41087YS Phage shock protein A GNE05_RS03615 ENOG4105DQX Zinc finger domain GNE05_RS03620 ENOG4108WV1 Pfam:DUF477 GNE05_RS03630 ENOG4105EXC Acyl-transferase GNE05_RS03635 ENOG4108P49 AntiSigma factor GNE05_RS03640 ENOG4105JVQ RNA Polymerase GNE05_RS03670 ENOG4107STQ Multicopper oxidase GNE05_RS03675 ENOG4105C85 amino acid GNE05_RS03685 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GNE05_RS03700 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GNE05_RS03705 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GNE05_RS03725 ENOG4105E5W Transporter GNE05_RS03740 ENOG4105C7N Xanthine uracil vitamin C permease GNE05_RS03765 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GNE05_RS03770 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GNE05_RS03775 ENOG4105C83 adenylosuccinate lyase GNE05_RS03780 ENOG4105C8V SAICAR synthetase GNE05_RS03785 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GNE05_RS03790 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GNE05_RS03795 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GNE05_RS03805 ENOG4105CXB phosphoribosylaminoimidazole synthetase GNE05_RS03810 ENOG4108V3E phosphoribosylglycinamide formyltransferase GNE05_RS03815 ENOG4105DC1 bifunctional purine biosynthesis protein purh GNE05_RS03820 ENOG4105C12 Phosphoribosylglycinamide synthetase GNE05_RS03835 ENOG4108R5T secreted protein GNE05_RS03840 ENOG4105KGF protein, YerC YecD GNE05_RS03845 ENOG4105CBC glutamate synthase GNE05_RS03855 ENOG4105C4R Atp-dependent dna helicase GNE05_RS03860 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GNE05_RS03870 ENOG4105CRN Aminoglycoside phosphotransferase GNE05_RS03875 ENOG4105KT7 mgtC SapB transporter GNE05_RS03880 ENOG4105CK7 Sodium proline symporter GNE05_RS03885 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GNE05_RS03890 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GNE05_RS03895 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GNE05_RS03900 ENOG4108IG5 Transcriptional regulator GNE05_RS03910 ENOG4105CBD Diacylglycerol kinase GNE05_RS03915 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GNE05_RS03965 ENOG4106BHF GNE05_RS03970 ENOG4105CDY transcriptional regulatory protein GNE05_RS03990 ENOG4105WEF catalase GNE05_RS03995 ENOG4105M18 -acetyltransferase GNE05_RS04005 ENOG4105H67 Protein of unknown function (DUF421) GNE05_RS04010 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GNE05_RS04015 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GNE05_RS04035 ENOG4106I4J membrane GNE05_RS04040 ENOG41082F9 transcriptional regulator GNE05_RS04045 ENOG41061H0 Monooxygenase GNE05_RS04050 ENOG4108R1P GNE05_RS04055 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GNE05_RS04060 ENOG4105E0M Sulfatase GNE05_RS04065 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GNE05_RS04075 ENOG41090R9 glycosyltransferase GNE05_RS04080 ENOG4107R51 Glycosyl transferase, family 2 GNE05_RS04085 ENOG41090R9 glycosyltransferase GNE05_RS04090 ENOG4105EU0 Major facilitator Superfamily GNE05_RS04095 ENOG4105CUB amino acid GNE05_RS04100 ENOG4105C26 Dehydrogenase GNE05_RS04105 ENOG4105FKZ Methyl-accepting chemotaxis GNE05_RS04110 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GNE05_RS04115 ENOG4107TVC Glycosyl transferase, family 2 GNE05_RS04120 ENOG4105C5H ABC transporter GNE05_RS04125 ENOG4107SWG transcriptional regulator MERR family GNE05_RS04130 ENOG4105DXB Major Facilitator superfamily GNE05_RS04135 ENOG4105C5H ABC transporter GNE05_RS04140 ENOG4105FDU atp-dependent rna helicase GNE05_RS04150 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GNE05_RS04165 ENOG4108J20 pectate lyase GNE05_RS04170 ENOG4107QPK )-transporter GNE05_RS04195 ENOG4108MRH transcriptional regulatory protein GNE05_RS04220 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) GNE05_RS04225 ENOG4108RPX mosc domain containing protein GNE05_RS04245 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) GNE05_RS04285 ENOG4105C5Y PTS System GNE05_RS04290 ENOG4105CG3 alpha amylase, catalytic region GNE05_RS04295 ENOG4107414 GntR family transcriptional regulator GNE05_RS04300 ENOG4108RCM Nitroreductase GNE05_RS04315 ENOG4105CGH 5'-nucleotidase GNE05_RS04320 ENOG4107RKG DJ-1/PfpI family GNE05_RS04325 ENOG4105ETE Transcriptional regulator (LacI family GNE05_RS04330 ENOG4105E2X shikimate dehydrogenase GNE05_RS04335 ENOG4105FF2 Type I DHQase GNE05_RS04350 ENOG4105KJF protein tyrosine phosphatase GNE05_RS04360 ENOG4107U9T Pfam:Ribonuclease_BN GNE05_RS04365 ENOG4108ISG Major Facilitator GNE05_RS04370 ENOG4105UPD Calcium Proton GNE05_RS04380 ENOG4105D8X mechanosensitive ion channel GNE05_RS04400 ENOG4106KE4 Dehydrogenase GNE05_RS04410 ENOG4105D7N magnesium and cobalt transport protein CorA GNE05_RS04420 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GNE05_RS04440 ENOG4107RUY (E1 component), alpha subunit GNE05_RS04450 ENOG4107QKR Dehydrogenase GNE05_RS04460 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GNE05_RS04470 ENOG4105F8D glycoside hydrolase family 4 GNE05_RS04475 ENOG4108Q3X Transcriptional regulator GNE05_RS04480 ENOG4105CI1 PTS System GNE05_RS04485 ENOG4105BZ1 (ABC) transporter GNE05_RS04490 ENOG4105BZ1 (ABC) transporter GNE05_RS04500 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GNE05_RS04505 ENOG4105ID8 Transcriptional regulator, ARAC family GNE05_RS04510 ENOG4107QNK )-transporter GNE05_RS04515 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GNE05_RS04520 ENOG4105CIB oxidoreductase Domain protein GNE05_RS04525 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GNE05_RS04530 ENOG4105U3E Transcriptional regulator GNE05_RS04535 ENOG4105DYS nad(p)h dehydrogenase (quinone) GNE05_RS04540 ENOG4105H93 Acyltransferase family GNE05_RS04555 ENOG4108YYS metal-dependent hydrolase (By similarity) GNE05_RS04560 ENOG4105C0R drug resistance transporter emrb qaca subfamily GNE05_RS04565 ENOG410834F Transcriptional regulator GNE05_RS04575 ENOG4105JAB phenazine biosynthesis protein, phzf family GNE05_RS04580 ENOG4107Y03 Nitroreductase GNE05_RS04595 ENOG4105ECP epimerase GNE05_RS04600 ENOG410902V Modulates RecA activity (By similarity) GNE05_RS04610 ENOG4105F27 Major Facilitator GNE05_RS04620 ENOG4108TCS Glutamyl endopeptidase GNE05_RS04640 ENOG4106AKJ GNE05_RS04645 ENOG4105D74 hydrolase GNE05_RS04650 ENOG4105CKK Glycosyl transferase, family 2 GNE05_RS04655 ENOG4105EJV Membrane GNE05_RS04660 ENOG41067AE Membrane-bound metal-dependent hydrolase GNE05_RS04665 ENOG4105CEN a g-specific adenine glycosylase GNE05_RS04670 ENOG4106BXE GNE05_RS04675 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GNE05_RS04695 ENOG4105BZ1 (ABC) transporter GNE05_RS04700 ENOG4107NBY Membrane GNE05_RS04705 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GNE05_RS04710 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GNE05_RS04715 ENOG4105G5W regulator Fur family GNE05_RS04720 ENOG4105TUA UPF0295 protein GNE05_RS04825 ENOG4107S6Z Na H antiporter GNE05_RS04830 ENOG4105EC3 peptidase S51, dipeptidase E GNE05_RS04835 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GNE05_RS04840 ENOG4105DNP FAD linked oxidase domain protein GNE05_RS04850 ENOG4105DEF Extracellular solute-binding protein, family 5 GNE05_RS04860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNE05_RS04870 ENOG4108JQ7 (ABC) transporter GNE05_RS04885 ENOG4105E2Y ABC, transporter GNE05_RS04890 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein GNE05_RS04895 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GNE05_RS04905 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GNE05_RS04910 ENOG4107D63 GNE05_RS04915 ENOG4105VZ8 Transcriptional regulator GNE05_RS04930 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GNE05_RS04940 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GNE05_RS04960 ENOG4105CYN Serine protein kinase GNE05_RS04970 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GNE05_RS04975 ENOG4105CW7 secretion protein, HlyD family GNE05_RS04980 ENOG4105C0R drug resistance transporter emrb qaca subfamily GNE05_RS04985 ENOG4105CS1 NAD(P)H quinone oxidoreductase GNE05_RS05000 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GNE05_RS05005 ENOG4105CZV ABC transporter GNE05_RS05010 ENOG4105CJ1 ABC, transporter GNE05_RS05015 ENOG4108TU7 Inherit from COG: (ABC) transporter GNE05_RS05020 ENOG4105VEQ Cold shock protein GNE05_RS05030 ENOG4105BZU Histidine kinase GNE05_RS05070 ENOG4108YBP pseudouridine synthase GNE05_RS05080 ENOG41080XP Cbs domain GNE05_RS05085 ENOG4107YBY Hydrolase GNE05_RS05090 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GNE05_RS05095 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GNE05_RS05100 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GNE05_RS05110 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GNE05_RS05115 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GNE05_RS05125 ENOG4105BZU Histidine kinase GNE05_RS05130 ENOG4105WH1 Two component transcriptional regulator luxr family GNE05_RS05165 ENOG4105ED1 spovr family GNE05_RS05170 ENOG4105G6Z alkaline phosphatase GNE05_RS05185 ENOG4105BZN citrate synthase GNE05_RS05190 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GNE05_RS05195 ENOG4105CUB amino acid GNE05_RS05200 ENOG4105C8J )-transporter GNE05_RS05210 ENOG4105J37 GNE05_RS05215 ENOG4108AEY RNA polymerase sigma factor GNE05_RS05220 ENOG4105F6E Acyl-transferase GNE05_RS05225 ENOG4105C37 (CBS) domain GNE05_RS05235 ENOG4105CHM Aminotransferase GNE05_RS05240 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase GNE05_RS05245 ENOG4105C37 (CBS) domain GNE05_RS05255 ENOG4105WMR Protein CrcB homolog GNE05_RS05260 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GNE05_RS05270 ENOG4105D64 Mechanosensitive ion channel GNE05_RS05275 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GNE05_RS05280 ENOG4107VMI polysaccharide deacetylase GNE05_RS05285 ENOG4105F0I Aminotransferase GNE05_RS05290 ENOG4105W1N transcriptional regulator GNE05_RS05295 ENOG4105IIP Membrane GNE05_RS05305 ENOG4105BZ1 (ABC) transporter GNE05_RS05310 ENOG4105BZ1 (ABC) transporter GNE05_RS05330 ENOG410839P GNE05_RS05340 ENOG4106MP8 UPF0754 membrane protein GNE05_RS05345 ENOG4105WZB UPF0342 protein GNE05_RS05360 ENOG4105D4P Coproporphyrinogen iii oxidase GNE05_RS05370 ENOG4107S91 Sodium hydrogen exchanger GNE05_RS05375 ENOG4105NCW Trka-c domain protein GNE05_RS05385 ENOG4105CGU Enoyl-CoA hydratase GNE05_RS05395 ENOG4108IUX (ABC) transporter GNE05_RS05400 ENOG4105RHA ABC transporter, permease GNE05_RS05405 ENOG4107VRP DNA repair exonuclease GNE05_RS05410 ENOG4106D4I domain protein GNE05_RS05415 ENOG4105EQI Metal Dependent Phosphohydrolase GNE05_RS05425 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GNE05_RS05470 ENOG4105NBU tryptophan transport protein GNE05_RS05475 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GNE05_RS05480 ENOG4105K59 histidine triad (HIT) protein GNE05_RS05510 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GNE05_RS05515 ENOG4105BZ4 penicillin-binding protein GNE05_RS05520 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GNE05_RS05525 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GNE05_RS05530 ENOG4105C1Q protoporphyrinogen oxidase GNE05_RS05540 ENOG4105ECB domain protein GNE05_RS05555 ENOG4105DER m42 family GNE05_RS05565 ENOG4106AXD GNE05_RS05570 ENOG4108RQ5 Beta-lactamase domain-containing protein GNE05_RS05575 ENOG4105DF9 Lipoate-protein, ligase GNE05_RS05585 ENOG4105CEY Amp-dependent synthetase and ligase GNE05_RS05595 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GNE05_RS05610 ENOG4108HUF Transporter GNE05_RS05615 ENOG4107TB6 phosphoglycerate mutase GNE05_RS05625 ENOG4107F3J Amp-dependent synthetase and ligase GNE05_RS05630 ENOG4107ZYJ bioY protein GNE05_RS05635 ENOG4106YBV Methyl-accepting chemotaxis GNE05_RS05655 ENOG4105XVF Competence transcription factor GNE05_RS05665 ENOG4108ZMX Domain of unknown function (DU1801) GNE05_RS05680 ENOG4105X3H Excalibur domain protein GNE05_RS05685 ENOG4105K8R UPF0145 protein GNE05_RS05690 ENOG4105E1V na solute symporter GNE05_RS05695 ENOG4106CAD Protein of unknown function (DUF3311) GNE05_RS05700 ENOG41060YP GNE05_RS05715 ENOG4107SCK Monooxygenase GNE05_RS05720 ENOG4108INS Transcriptional regulator GNE05_RS05725 ENOG4108KK1 membrane protein AbrB duplication GNE05_RS05735 ENOG4108IG5 Transcriptional regulator GNE05_RS05745 ENOG4108QY0 Membrane GNE05_RS05750 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination GNE05_RS05755 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GNE05_RS05765 ENOG4105EYH Exonuclease GNE05_RS05810 ENOG4105ERH Fumarylacetoacetate hydrolase GNE05_RS05825 ENOG4105CAQ asparagine synthetase GNE05_RS05835 ENOG4105UQX Mate efflux family protein GNE05_RS05840 ENOG4106HBX Transcriptional Regulator AraC Family GNE05_RS05845 ENOG4105SF0 DinB family GNE05_RS05850 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GNE05_RS05855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNE05_RS05860 ENOG4105MYW Pentapeptide repeat protein GNE05_RS05865 ENOG4105MA6 gCN5-related N-acetyltransferase GNE05_RS05875 ENOG4108VPT UPF0234 protein GNE05_RS05880 ENOG4105QNR S1 RNA binding domain protein GNE05_RS05885 ENOG4105DIH basic membrane GNE05_RS05890 ENOG4105C8Q Methyl-accepting chemotaxis GNE05_RS05895 ENOG4107E6A Cytochrome p-450 GNE05_RS05905 ENOG4105EPR degv family GNE05_RS05910 ENOG4107AYK membrAne GNE05_RS05920 ENOG41073B9 GNE05_RS05925 ENOG4108KP7 hydrolase GNE05_RS05930 ENOG4108MXZ Esterase GNE05_RS05935 ENOG4105VG1 fes assembly suf system protein GNE05_RS05940 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GNE05_RS05945 ENOG4105IQ5 FAD linked oxidase domain protein GNE05_RS05955 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GNE05_RS05965 ENOG4105CAS nag kinase GNE05_RS05970 ENOG4105C8Y Acetylornithine aminotransferase GNE05_RS05975 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GNE05_RS05985 ENOG4105DBV ornithine carbamoyltransferase GNE05_RS06010 ENOG4107RMD Basic membrane lipoprotein GNE05_RS06025 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GNE05_RS06030 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GNE05_RS06040 ENOG4105C3U ABC transporter GNE05_RS06045 ENOG4108JQ7 (ABC) transporter GNE05_RS06060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNE05_RS06080 ENOG4105C31 Tryptophanyl-tRNA synthetase GNE05_RS06085 ENOG4108J59 Extracellular solute-binding protein, family 5 GNE05_RS06090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GNE05_RS06095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNE05_RS06105 ENOG4108JQ7 (ABC) transporter GNE05_RS06120 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GNE05_RS06125 ENOG4108ZCF integral membrane protein GNE05_RS06130 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis GNE05_RS06140 ENOG4105DPN Oligoendopeptidase f GNE05_RS06145 ENOG4105T58 Dithiol-disulfide isomerase GNE05_RS06150 ENOG4108Z18 K06886 hemoglobin GNE05_RS06155 ENOG4105E4C Lytic transglycosylase catalytic GNE05_RS06160 ENOG4105MIX Adenylate cyclase GNE05_RS06175 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GNE05_RS06180 ENOG4105EMS pseudouridine synthase GNE05_RS06185 ENOG4107S1Q Phosphatase GNE05_RS06195 ENOG4105ETU transcriptional activator (TenA GNE05_RS06200 ENOG4108VEU Thiamine monophosphate synthase GNE05_RS06220 ENOG4105D06 uba thif-type nad fad binding protein GNE05_RS06225 ENOG4105DWF phosphomethylpyrimidine kinase GNE05_RS06230 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GNE05_RS06235 ENOG4107A88 GNE05_RS06285 ENOG4105ENA helicase GNE05_RS06305 ENOG4105CJ1 ABC, transporter GNE05_RS06320 ENOG4108ZMI UPF0477 protein GNE05_RS06330 ENOG4105C28 cystathionine GNE05_RS06335 ENOG4105C28 cystathionine GNE05_RS06400 ENOG4107NTZ GNE05_RS06470 ENOG4105C0R drug resistance transporter emrb qaca subfamily GNE05_RS06485 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase GNE05_RS06490 ENOG4105CMR udp-glucose 4-epimerase GNE05_RS06495 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GNE05_RS06500 ENOG4105CK1 PTS System GNE05_RS06505 ENOG4105VCP PTS System GNE05_RS06530 ENOG4105KT7 mgtC SapB transporter GNE05_RS06555 ENOG4108IEG Formate dehydrogenase Alpha subunit GNE05_RS06565 ENOG4106A3M Cytochrome p-450 GNE05_RS06570 ENOG41087PP glycosyltransferase MGT family GNE05_RS06580 ENOG4105EXQ uroporphyrinogen iii synthase hem4 GNE05_RS06585 ENOG4105C4B ABC transporter, permease GNE05_RS06590 ENOG4108IXI (ABC) transporter GNE05_RS06600 ENOG4105Q95 Cupin 2, conserved barrel domain protein GNE05_RS06615 ENOG4105D2H Uronic isomerase GNE05_RS06620 ENOG4105CT4 transporter GNE05_RS06625 ENOG4107KJX Transcriptional regulator GNE05_RS06630 ENOG4107QZW Altronate oxidoreductase GNE05_RS06635 ENOG4105CTX dehydratase GNE05_RS06640 ENOG4107TSN permease GNE05_RS06660 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GNE05_RS06665 ENOG4105KWG Pfam:DUF1696 GNE05_RS06670 ENOG4105K7W phage-related replication protein GNE05_RS06675 ENOG4105WEF catalase GNE05_RS06680 ENOG410635T phage-like element pbsx protein GNE05_RS06720 ENOG4108TFU terminase (Small subunit) GNE05_RS06725 ENOG4105IG6 Phage terminase, large subunit GNE05_RS06730 ENOG4108MDF Phage Portal Protein GNE05_RS06755 ENOG41060SN GNE05_RS06770 ENOG4105PQS phage protein GNE05_RS06775 ENOG4105FR7 XkdM protein, phage-like element PBSX GNE05_RS06780 ENOG4105MTC XkdN-like protein GNE05_RS06790 ENOG4108FKH Transglycosylase SLT domain GNE05_RS06790 ENOG4108FKH Transglycosylase SLT domain GNE05_RS06790 ENOG4108FKH Transglycosylase SLT domain GNE05_RS06795 ENOG4108WZM domain protein GNE05_RS06800 ENOG4105X7F GNE05_RS06810 ENOG4105MFU Protein of unknown function (DUF2634) GNE05_RS06815 ENOG41066EA baseplate J family protein GNE05_RS06820 ENOG410906S phage-like element pbsx protein xkdt GNE05_RS06830 ENOG41068G1 GNE05_RS06860 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GNE05_RS06875 ENOG4105CJ3 phosphate transporter GNE05_RS06880 ENOG4107GRR phosphate transport regulator GNE05_RS06885 ENOG4107R7I amino acid GNE05_RS06895 ENOG4105EDW glycosyl transferase, family 39 GNE05_RS06900 ENOG4105CKK Glycosyl transferase, family 2 GNE05_RS06905 ENOG4105C0H protease GNE05_RS06915 ENOG4108ME1 Peptidase M55 D-aminopeptidase GNE05_RS06920 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GNE05_RS06925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNE05_RS06930 ENOG4105C3U ABC transporter GNE05_RS06940 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GNE05_RS06945 ENOG4105DTQ mandelate racemase muconate lactonizing GNE05_RS06950 ENOG4107SN7 NLP P60 protein GNE05_RS06955 ENOG4108JQ7 (ABC) transporter GNE05_RS06960 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GNE05_RS06965 ENOG4107TUM Amidinotransferase GNE05_RS06970 ENOG4108S4H thioesterase Superfamily protein GNE05_RS06975 ENOG4108428 Inherit from COG: -acetyltransferase GNE05_RS06985 ENOG41080TC multidrug resistance protein GNE05_RS06990 ENOG4105CIY formyltetrahydrofolate deformylase GNE05_RS06995 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GNE05_RS07010 ENOG4105K56 Transcriptional regulator GNE05_RS07015 ENOG4108ZHJ Organic hydroperoxide resistance protein GNE05_RS07030 ENOG4107TVC Glycosyl transferase, family 2 GNE05_RS07040 ENOG4105D8G Major Facilitator superfamily GNE05_RS07045 ENOG4108Y4K DNA-binding transcriptional activator GNE05_RS07050 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GNE05_RS07055 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GNE05_RS07065 ENOG4108W7F transporter, permease GNE05_RS07070 ENOG4108JJB ABC transporter GNE05_RS07075 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein GNE05_RS07080 ENOG4105VRS hydrolase family 18 GNE05_RS07095 ENOG4105CJW magnesium transporter GNE05_RS07100 ENOG4105V75 Transcriptional regulator GNE05_RS07125 ENOG4105DQE DNA ligase GNE05_RS07130 ENOG4105FDF Could be involved in DNA repair (By similarity) GNE05_RS07135 ENOG4107T5V SNARE associated Golgi GNE05_RS07140 ENOG4107TS3 membrane protein, TerC GNE05_RS07145 ENOG4108WZW RNA polymerase sigma GNE05_RS07155 ENOG410681C small acid-soluble spore protein GNE05_RS07175 ENOG410900G Protein of unknown function (DUF421) GNE05_RS07185 ENOG4108TGC Acyltransferase GNE05_RS07190 ENOG4105BZU Histidine kinase GNE05_RS07195 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GNE05_RS07200 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GNE05_RS07210 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GNE05_RS07220 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GNE05_RS07225 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) GNE05_RS07230 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GNE05_RS07235 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GNE05_RS07245 ENOG4105BZU Histidine kinase GNE05_RS07250 ENOG41090MY MarR family Transcriptional regulator GNE05_RS07255 ENOG4105ER2 Ompa motb domain protein GNE05_RS07260 ENOG4105E14 MotA TolQ exbB proton channel GNE05_RS07270 ENOG4108K88 Membrane GNE05_RS07280 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GNE05_RS07285 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase GNE05_RS07290 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GNE05_RS07295 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GNE05_RS07310 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GNE05_RS07320 ENOG4105FEA Spore maturation protein GNE05_RS07350 ENOG4105F0V Cell wall hydrolase GNE05_RS07365 ENOG4105C59 p-type ATPase GNE05_RS07370 ENOG4105DC7 peptidase M24 GNE05_RS07380 ENOG4105CID antiterminator GNE05_RS07390 ENOG4105KRI phosphocarrier protein (HPr GNE05_RS07395 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GNE05_RS07405 ENOG4105F6S Spore photoproduct lyase GNE05_RS07410 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GNE05_RS07415 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GNE05_RS07420 ENOG4105K4I Scp-like extracellular GNE05_RS07430 ENOG4105BZU Histidine kinase GNE05_RS07435 ENOG4105CHM Aminotransferase GNE05_RS07440 ENOG4107R88 Chemotaxis protein (CheV) GNE05_RS07445 ENOG4105UIN GNE05_RS07455 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GNE05_RS07465 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GNE05_RS07475 ENOG4105EPM Diguanylate phosphodiesterase GNE05_RS07480 ENOG4107IN1 Protein of unknown function (DUF1797) GNE05_RS07485 ENOG4108XRC Protein of unknown function (DUF458) GNE05_RS07515 ENOG4105NQC Flavodoxin GNE05_RS07535 ENOG4105D8X mechanosensitive ion channel GNE05_RS07540 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GNE05_RS07555 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GNE05_RS07560 ENOG4105D06 uba thif-type nad fad binding protein GNE05_RS07565 ENOG4105CVM Molybdenum cofactor synthesis domain protein GNE05_RS07570 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GNE05_RS07575 ENOG4108ZAF Molybdopterin GNE05_RS07580 ENOG41067WU Molybdopterin converting factor (Subunit 1) GNE05_RS07590 ENOG4107X8C Efflux transporter RND family MFP subunit GNE05_RS07595 ENOG4105C19 ABC transporter GNE05_RS07600 ENOG4107RBB ABC transporter, permease GNE05_RS07605 ENOG4105E98 transcriptional regulator DeoR family GNE05_RS07610 ENOG4105DE4 1-phosphofructokinase GNE05_RS07615 ENOG4105DM4 PTS System GNE05_RS07630 ENOG4105C5H ABC transporter GNE05_RS07635 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GNE05_RS07660 ENOG4105BZU Histidine kinase GNE05_RS07670 ENOG4107ZYR domain protein GNE05_RS07675 ENOG4105CPN adenine deaminase GNE05_RS07680 ENOG4105CN5 Metallo-Beta-Lactamase GNE05_RS07685 ENOG4106148 UPF0356 protein GNE05_RS07690 ENOG4108X4Q Hydrolase GNE05_RS07695 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GNE05_RS07710 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GNE05_RS07715 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS07720 ENOG4107SQU synthase GNE05_RS07725 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS07730 ENOG4107SQU synthase GNE05_RS07735 ENOG4107SQU synthase GNE05_RS07740 ENOG4107SQU synthase GNE05_RS07745 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS07750 ENOG4105FQP Beta-lactamase GNE05_RS07760 ENOG4105CPP Dehydrogenase, E1 component GNE05_RS07765 ENOG4105C7S Dehydrogenase GNE05_RS07770 ENOG4107QN2 dihydrolipoyl dehydrogenase GNE05_RS07790 ENOG4105CXN decarboxylase GNE05_RS07795 ENOG4105WBI UPF0223 protein GNE05_RS07810 ENOG4105ECY inositol monophosphatase GNE05_RS07820 ENOG4105D4Y metalloprotease GNE05_RS07845 ENOG4105CI3 gtp-binding protein typa GNE05_RS07850 ENOG4105QA2 GNE05_RS07865 ENOG4108IAB Phoh family GNE05_RS07875 ENOG4105CSV Glutaminase GNE05_RS07885 ENOG4105CNI cell division protein FtsW GNE05_RS07890 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GNE05_RS07900 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GNE05_RS07910 ENOG4105BZ9 Cytochrome C oxidase, subunit I GNE05_RS07915 ENOG4105CCU oxidase (Subunit III) GNE05_RS07920 ENOG41064X9 cytochrome C oxidase subunit IV GNE05_RS07940 ENOG41080XQ Signal transduction protein with cbs domains GNE05_RS07945 ENOG4106UY4 Inherit from COG: Scp-like extracellular GNE05_RS07970 ENOG4106H78 methyltransferase GNE05_RS07975 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GNE05_RS07980 ENOG4105H20 Sporulation integral membrane protein YlbJ GNE05_RS07985 ENOG4105D78 K07001 NTE family protein GNE05_RS07990 ENOG41063PX domain protein GNE05_RS08000 ENOG4105CDE UPF0348 protein GNE05_RS08005 ENOG4105KNH Nucleic acid-binding protein GNE05_RS08010 ENOG41067VY 50S ribosomal protein L32 GNE05_RS08035 ENOG4108V6E Cell division protein mraZ GNE05_RS08040 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GNE05_RS08050 ENOG4105CJN penicillin-binding protein GNE05_RS08055 ENOG4105CJN penicillin-binding protein GNE05_RS08060 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GNE05_RS08065 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GNE05_RS08070 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GNE05_RS08075 ENOG4105CNI cell division protein FtsW GNE05_RS08080 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GNE05_RS08085 ENOG4105D4A Cell wall formation (By similarity) GNE05_RS08090 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GNE05_RS08095 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GNE05_RS08100 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GNE05_RS08110 ENOG4105FFI sigma-e processing peptidase spoiiga GNE05_RS08115 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE05_RS08125 ENOG4105DKW ABC transporter GNE05_RS08135 ENOG4105WR5 sporulation protein, YlmC YmxH family GNE05_RS08140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GNE05_RS08145 ENOG4105DFA alanine racemase domain protein GNE05_RS08150 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GNE05_RS08155 ENOG41067XK integral membrane protein GNE05_RS08160 ENOG4105DBK s4 domain protein GNE05_RS08170 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GNE05_RS08180 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GNE05_RS08185 ENOG4105C34 Pseudouridine synthase GNE05_RS08190 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GNE05_RS08200 ENOG4105CXT aspartate transcarbamylase GNE05_RS08210 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GNE05_RS08215 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GNE05_RS08220 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GNE05_RS08225 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GNE05_RS08230 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GNE05_RS08235 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GNE05_RS08250 ENOG4107RIQ Sulfate adenylate transferase GNE05_RS08260 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GNE05_RS08265 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GNE05_RS08270 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GNE05_RS08275 ENOG4105F23 Fibronectin-binding protein GNE05_RS08285 ENOG4105DSJ YicC domain protein GNE05_RS08290 ENOG4105KC4 UPF0296 protein GNE05_RS08295 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GNE05_RS08305 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GNE05_RS08310 ENOG4105C25 Primosomal protein n' GNE05_RS08315 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GNE05_RS08320 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GNE05_RS08325 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GNE05_RS08330 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GNE05_RS08335 ENOG4108ZF3 Phosphatase GNE05_RS08340 ENOG4105D9P serine threonine protein kinase GNE05_RS08345 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GNE05_RS08350 ENOG4105DJV ribulose-phosphate 3-epimerase GNE05_RS08355 ENOG4105FJ0 thiamine GNE05_RS08365 ENOG4105VB9 50S ribosomal protein l28 GNE05_RS08370 ENOG4108ZAA Alkaline-shock protein GNE05_RS08375 ENOG4105DP4 dak2 domain fusion protein ylov GNE05_RS08385 ENOG4105EJQ L-serine dehydratase GNE05_RS08390 ENOG4105CB5 ATP-dependent DNA helicase recG GNE05_RS08395 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GNE05_RS08400 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GNE05_RS08405 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GNE05_RS08410 ENOG4105CHR reductase GNE05_RS08415 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GNE05_RS08420 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GNE05_RS08425 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GNE05_RS08430 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GNE05_RS08440 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GNE05_RS08450 ENOG4105K5M 30s ribosomal protein S16 GNE05_RS08455 ENOG4108BW8 UPF0109 protein GNE05_RS08470 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GNE05_RS08475 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GNE05_RS08480 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GNE05_RS08485 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GNE05_RS08495 ENOG4105VM1 flagellar GNE05_RS08500 ENOG4105CMV Succinyl-CoA synthetase subunit beta GNE05_RS08505 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GNE05_RS08510 ENOG4105C79 DNA protecting protein DprA GNE05_RS08515 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GNE05_RS08520 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GNE05_RS08525 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GNE05_RS08530 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GNE05_RS08535 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GNE05_RS08545 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GNE05_RS08550 ENOG4108ZC9 flagellar basal-body rod protein flgc GNE05_RS08555 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GNE05_RS08560 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GNE05_RS08565 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GNE05_RS08580 ENOG4106YF4 Flagellar biosynthesis chaperone GNE05_RS08590 ENOG410696Y Flagellar hook-length control protein GNE05_RS08595 ENOG410822I Flagellar hook capping protein GNE05_RS08600 ENOG4108JQA flagellar GNE05_RS08605 ENOG41068WV flagellar FlbD family protein GNE05_RS08615 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GNE05_RS08620 ENOG4105DD5 Flagellar motor switch protein GNE05_RS08625 ENOG4107YTP response regulator receiver protein GNE05_RS08635 ENOG4105CN7 Flagellar biosynthetic protein FliP GNE05_RS08640 ENOG4105VS8 Flagellar biosynthetic protein fliq GNE05_RS08645 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GNE05_RS08650 ENOG4105D00 flagellar biosynthetic protein flhB GNE05_RS08655 ENOG4105D7B Flagellar biosynthesis protein flha GNE05_RS08660 ENOG4105FZW flagellar biosynthesis regulator FlhF GNE05_RS08670 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GNE05_RS08675 ENOG4105CBS Chea signal transduction histidine kinase GNE05_RS08680 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis GNE05_RS08690 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GNE05_RS08695 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE05_RS08705 ENOG4105CE9 30S ribosomal protein S2 GNE05_RS08715 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GNE05_RS08720 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GNE05_RS08725 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GNE05_RS08730 ENOG4105KNE Phosphatidate cytidylyltransferase GNE05_RS08740 ENOG4105DZP Membrane-associated zinc metalloprotease GNE05_RS08745 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GNE05_RS08750 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GNE05_RS08755 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GNE05_RS08760 ENOG4105CHV Transcription elongation factor NusA GNE05_RS08765 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GNE05_RS08770 ENOG4105VHM ribosomal protein GNE05_RS08775 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GNE05_RS08780 ENOG4105W7A Protein of unknown function (DUF503) GNE05_RS08785 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GNE05_RS08790 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GNE05_RS08795 ENOG4105DTN riboflavin biosynthesis protein ribF GNE05_RS08800 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GNE05_RS08805 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GNE05_RS08815 ENOG4105C1V Peptidase, M16 GNE05_RS08825 ENOG4105E35 Dipicolinate synthase subunit A GNE05_RS08830 ENOG4108S0H Dipicolinic acid synthetase, b subunit GNE05_RS08835 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GNE05_RS08845 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GNE05_RS08855 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GNE05_RS08865 ENOG4105CNU cell division protein FtsK GNE05_RS08870 ENOG4105FDP GntR family transcriptional regulator GNE05_RS08885 ENOG4105EYF MMPL domain protein GNE05_RS08900 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GNE05_RS08905 ENOG4105XZV Protein of unknown function (DUF3243) GNE05_RS08920 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GNE05_RS08925 ENOG4105CEV competence damage-inducible protein GNE05_RS08930 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GNE05_RS08935 ENOG4108A04 Beta-lactamase GNE05_RS08945 ENOG4105D48 metallophosphoesterase GNE05_RS08950 ENOG4105MCT stage V sporulation protein S GNE05_RS08955 ENOG4105CPQ Dehydrogenase GNE05_RS08960 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GNE05_RS08965 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GNE05_RS08985 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GNE05_RS09035 ENOG4108151 Beta-lactamase domain protein GNE05_RS09040 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GNE05_RS09045 ENOG4108JA1 polyketide synthase GNE05_RS09050 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GNE05_RS09055 ENOG41062T2 Acyl carrier protein GNE05_RS09060 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GNE05_RS09065 ENOG4108MGH Enoyl-CoA hydratase GNE05_RS09070 ENOG4108KQ6 Enoyl-CoA hydratase GNE05_RS09075 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS09080 ENOG4107SQU synthase GNE05_RS09090 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS09100 ENOG4106A3M Cytochrome p-450 GNE05_RS09105 ENOG4105WFK nuclease GNE05_RS09110 ENOG4105XPP Protein of unknown function (DUF1275) GNE05_RS09120 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GNE05_RS09130 ENOG4105K7W phage-related replication protein GNE05_RS09135 ENOG4108X3M OsmC Ohr family protein GNE05_RS09160 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GNE05_RS09185 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GNE05_RS09190 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GNE05_RS09195 ENOG4105U6W MutT NUDIX family protein GNE05_RS09200 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GNE05_RS09210 ENOG4106F1P AAA ATPase, central domain protein GNE05_RS09215 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GNE05_RS09220 ENOG4105CXI aluminum resistance protein GNE05_RS09225 ENOG4105KV4 Transcriptional regulator GNE05_RS09230 ENOG4105C5F glutamine synthetase GNE05_RS09240 ENOG4105CT4 transporter GNE05_RS09245 ENOG4105DSG hydrolase family 43 GNE05_RS09255 ENOG4105C93 Xylose Isomerase GNE05_RS09260 ENOG4105CMG Carbohydrate kinase GNE05_RS09265 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GNE05_RS09285 ENOG4105D29 Helix-turn-helix type 11 domain protein GNE05_RS09290 ENOG4105SF0 DinB family GNE05_RS09295 ENOG4105DQ4 alcohol dehydrogenase GNE05_RS09310 ENOG4105EPI acetyltransferase, (GNAT) family GNE05_RS09315 ENOG4106BHF GNE05_RS09320 ENOG4106ANW SMI1_KNR4 GNE05_RS09360 ENOG4108M1A Chitin-binding protein GNE05_RS09370 ENOG41068WN GNE05_RS09385 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GNE05_RS09390 ENOG4105K7W phage-related replication protein GNE05_RS09410 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GNE05_RS09420 ENOG4108SVB resolvase GNE05_RS09425 ENOG4105VPS UPF0291 protein GNE05_RS09430 ENOG4105CV1 Transketolase (EC 2.2.1.1) GNE05_RS09440 ENOG4105VXM UPF0154 protein GNE05_RS09450 ENOG4107QIV Cytochrome c biogenesis protein GNE05_RS09485 ENOG4108I0Z Aconitate hydratase GNE05_RS09490 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GNE05_RS09505 ENOG41067CD Small, acid-soluble spore protein Tlp GNE05_RS09515 ENOG4105MI2 GNE05_RS09520 ENOG4105W8X HesB YadR YfhF-family protein GNE05_RS09525 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GNE05_RS09530 ENOG4105K4P CoA-binding domain protein GNE05_RS09535 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GNE05_RS09560 ENOG4105CPQ Dehydrogenase GNE05_RS09565 ENOG4108UHU Aldolase GNE05_RS09570 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GNE05_RS09575 ENOG4105DMW Dehydrogenase reductase GNE05_RS09585 ENOG4108I5G Major Facilitator superfamily GNE05_RS09600 ENOG4105FVX GNE05_RS09630 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE05_RS09640 ENOG4107SYN Glycosyl hydrolases family 43 GNE05_RS09665 ENOG4105DTD Dehydrogenase GNE05_RS09670 ENOG4108IIH CoA-transferase subunit B GNE05_RS09675 ENOG4105D6N CoA-transferase, subunit a GNE05_RS09680 ENOG4105CY2 Citrate transporter GNE05_RS09685 ENOG4106A3M Cytochrome p-450 GNE05_RS09690 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GNE05_RS09695 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GNE05_RS09700 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GNE05_RS09705 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GNE05_RS09710 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) GNE05_RS09720 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GNE05_RS09725 ENOG4107T5V SNARE associated Golgi GNE05_RS09730 ENOG4107QX3 carboxylase GNE05_RS09735 ENOG4105E39 Enoyl-CoA hydratase GNE05_RS09740 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GNE05_RS09745 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GNE05_RS09750 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GNE05_RS09755 ENOG4105CEY Amp-dependent synthetase and ligase GNE05_RS09760 ENOG4105C1G acyl-Coa dehydrogenase GNE05_RS09765 ENOG4105F32 YngK protein GNE05_RS09770 ENOG4106U2H Protein of unknown function (DUF1360) GNE05_RS09780 ENOG4105CEY Amp-dependent synthetase and ligase GNE05_RS09785 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS09795 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS09800 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family GNE05_RS09805 ENOG4108N2V aldose 1-epimerase GNE05_RS09835 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GNE05_RS09840 ENOG4108RWP Major Facilitator Superfamily protein GNE05_RS09845 ENOG4105WAB arsR family transcriptional regulator GNE05_RS09850 ENOG4105C22 threonyL-tRNA synthetase GNE05_RS09855 ENOG4108KSA LysR family transcriptional regulator GNE05_RS09860 ENOG4105CB2 alcohol dehydrogenase GNE05_RS09865 ENOG4105BZ8 glutamate synthase GNE05_RS09870 ENOG4105CBC glutamate synthase GNE05_RS09875 ENOG4105C5Q Transcriptional regulator GNE05_RS09880 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GNE05_RS09905 ENOG4108UB7 GNE05_RS09910 ENOG4105IE8 Alpha-ketoglutarate permease GNE05_RS09915 ENOG4107U6E carbohydrate kinase FGGY GNE05_RS09920 ENOG4108M3J Dehydrogenase GNE05_RS09925 ENOG4108J2R molybdopterin oxidoreductase GNE05_RS09950 ENOG4106ANW SMI1_KNR4 GNE05_RS09955 ENOG4106BHF GNE05_RS09960 ENOG4108Z7R Chaperone CsaA GNE05_RS09965 ENOG4105FTV AraC Family Transcriptional Regulator GNE05_RS09975 ENOG4108W8B Beta-lactamase domain protein GNE05_RS09985 ENOG4105KTU Transcriptional regulator, arsr family GNE05_RS09995 ENOG4108SJC Membrane GNE05_RS10020 ENOG41069ER domain protein GNE05_RS10025 ENOG4105C9U ATP-dependent DNA helicase RecQ GNE05_RS10035 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GNE05_RS10040 ENOG4105SCY DNAK suppressor GNE05_RS10085 ENOG4105C26 Dehydrogenase GNE05_RS10090 ENOG4105EWU Squalene--hopene cyclase GNE05_RS10095 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GNE05_RS10100 ENOG4105C8J )-transporter GNE05_RS10105 ENOG4105C09 Bile acid GNE05_RS10115 ENOG4105C7S Dehydrogenase GNE05_RS10120 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GNE05_RS10125 ENOG4107T89 von Willebrand factor, type A GNE05_RS10130 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GNE05_RS10140 ENOG4105K4H Nlp p60 protein GNE05_RS10145 ENOG41087PP glycosyltransferase MGT family GNE05_RS10155 ENOG4107QMU Mate efflux family protein GNE05_RS10160 ENOG4106SCS STAS domain GNE05_RS10180 ENOG4105FR1 rard protein GNE05_RS10195 ENOG41090U3 tautomerase GNE05_RS10215 ENOG4105FBA Phospholipase Carboxylesterase GNE05_RS10230 ENOG4105E1V na solute symporter GNE05_RS10240 ENOG4105CS2 ec 3.2.1.21 GNE05_RS10245 ENOG4108S3Y transcriptional regulator GNE05_RS10265 ENOG4108VXD carboxy-peptidase GNE05_RS10270 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GNE05_RS10280 ENOG4106Z5R GNE05_RS10285 ENOG410841Q phosphoesterase PA-phosphatase related protein GNE05_RS10310 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GNE05_RS10315 ENOG4108TSC N-acetyltransferase GNE05_RS10320 ENOG4107S4Y M20 DapE family protein YgeY GNE05_RS10335 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GNE05_RS10340 ENOG4105FTQ Dna gyrase GNE05_RS10410 ENOG410780I phosphoprotein phosphatase activity GNE05_RS10455 ENOG4106BHF GNE05_RS10465 ENOG4107Y9E nuclease GNE05_RS10490 ENOG4105E0X reductase GNE05_RS10495 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GNE05_RS10505 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) GNE05_RS10510 ENOG41090WU lipolytic protein G-D-S-L family GNE05_RS10515 ENOG4108KF3 Electron transport protein SCO1 SenC GNE05_RS10525 ENOG4105C7B Threonine dehydratase GNE05_RS10535 ENOG4108UT2 hemolysin iii GNE05_RS10550 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GNE05_RS10555 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GNE05_RS10565 ENOG4107YX5 Pfam:DUF548 GNE05_RS10570 ENOG4108Y6J UPF0403 protein GNE05_RS10575 ENOG4105C01 Dihydroxy-acid dehydratase GNE05_RS10590 ENOG4108V06 Glutathione peroxidase GNE05_RS10595 ENOG4105CVG Homoserine O-transsuccinylase GNE05_RS10640 ENOG41081VK Ribonuclease GNE05_RS10665 ENOG410890F Dynamin family GNE05_RS10680 ENOG41065KQ synthase GNE05_RS10715 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GNE05_RS10790 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GNE05_RS10795 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GNE05_RS10820 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GNE05_RS10830 ENOG4106ITI Glutaredoxin GNE05_RS10865 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GNE05_RS10870 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GNE05_RS10970 ENOG4106210 phosphatase activity GNE05_RS10990 ENOG4106J9J DNA polymerase GNE05_RS11000 ENOG4106IVX GNE05_RS11005 ENOG4106PTB DnaB-like helicase C terminal domain GNE05_RS11015 ENOG41088HM GNE05_RS11020 ENOG4106YR8 GNE05_RS11040 ENOG4105K7W phage-related replication protein GNE05_RS11055 ENOG4108RAV Conserved protein GNE05_RS11060 ENOG4108J9Q DNA ligase GNE05_RS11170 ENOG4107D0N GNE05_RS11215 ENOG4106J6E GNE05_RS11220 ENOG4107NTZ GNE05_RS11255 ENOG4108NE4 GNE05_RS11290 ENOG4105ZUG GNE05_RS11295 ENOG4105K70 DNA-binding protein GNE05_RS11405 ENOG41068G1 GNE05_RS11455 ENOG4105E4C Lytic transglycosylase catalytic GNE05_RS11480 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GNE05_RS11505 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GNE05_RS11515 ENOG4108YTE sporulation protein YunB GNE05_RS11540 ENOG4106BHF GNE05_RS11545 ENOG4107Y9E nuclease GNE05_RS11560 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GNE05_RS11565 ENOG4105CTD carboxy-peptidase GNE05_RS11570 ENOG4105DVT helicase GNE05_RS11585 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GNE05_RS11595 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) GNE05_RS11600 ENOG4108UKS UPF0398 protein GNE05_RS11615 ENOG4107X2U Inherit from COG: Exonuclease-like protein GNE05_RS11620 ENOG4108I5C dEAD DEAH box helicase GNE05_RS11665 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GNE05_RS11670 ENOG4105BZ4 penicillin-binding protein GNE05_RS11680 ENOG4105CSM endonuclease III GNE05_RS11690 ENOG4105C5S asparaginyl-tRNA synthetase GNE05_RS11695 ENOG4105CHM Aminotransferase GNE05_RS11705 ENOG4105YAC GNE05_RS11710 ENOG4105DVT helicase GNE05_RS11715 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GNE05_RS11725 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GNE05_RS11735 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GNE05_RS11740 ENOG4105CPK Glycosyl transferase (Group 1 GNE05_RS11745 ENOG4105FJR Lmbe family GNE05_RS11750 ENOG4108Z5K methylglyoxal synthase GNE05_RS11755 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GNE05_RS11760 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GNE05_RS11765 ENOG4108JYZ YitT family GNE05_RS11770 ENOG4105F0F Oxalate decarboxylase GNE05_RS11790 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GNE05_RS11810 ENOG41068YB TPR repeat-containing protein GNE05_RS11815 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GNE05_RS11825 ENOG4105CIH Imidazole acetol-phosphate transaminase GNE05_RS11835 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GNE05_RS11840 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GNE05_RS11845 ENOG4105DK0 Indole-3-glycerol phosphate synthase GNE05_RS11855 ENOG4105CRQ synthase (Component I) GNE05_RS11860 ENOG4105KHN chorismate mutase GNE05_RS11870 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GNE05_RS11875 ENOG4105BZU Histidine kinase GNE05_RS11880 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GNE05_RS11885 ENOG4105EAH synthase GNE05_RS11890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GNE05_RS11895 ENOG4105XXQ heptaprenyl diphosphate synthase component I GNE05_RS11900 ENOG4105WP2 Tryptophan RNA-binding attenuator protein GNE05_RS11905 ENOG4105EUJ GTP cyclohydrolase i GNE05_RS11910 ENOG4105K70 DNA-binding protein GNE05_RS11915 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GNE05_RS11930 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GNE05_RS11935 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GNE05_RS11955 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GNE05_RS11960 ENOG4105CAT Cytidine monophosphate kinase GNE05_RS11975 ENOG4105MSI germination protein ypeb GNE05_RS11985 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) GNE05_RS11990 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GNE05_RS12005 ENOG4107RGJ metallophosphoesterase GNE05_RS12020 ENOG4105I7S Abortive infection protein GNE05_RS12025 ENOG4105C9U ATP-dependent DNA helicase RecQ GNE05_RS12030 ENOG4105T7X GNE05_RS12040 ENOG4108SAX Membrane GNE05_RS12045 ENOG4108JQ1 Dehydrogenase GNE05_RS12060 ENOG4105BZU Histidine kinase GNE05_RS12065 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE05_RS12070 ENOG4105CRE cytochrome C GNE05_RS12075 ENOG4107TWT Cytochrome c biogenesis protein GNE05_RS12085 ENOG4105FE9 pseudouridine synthase GNE05_RS12095 ENOG4108JIC nucleoside recognition domain protein GNE05_RS12100 ENOG4105DZ1 carboxypeptidase GNE05_RS12110 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GNE05_RS12115 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GNE05_RS12135 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GNE05_RS12140 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GNE05_RS12145 ENOG4108R6K riboflavin synthase, subunit alpha GNE05_RS12170 ENOG4107ZE5 PPIases accelerate the folding of proteins GNE05_RS12175 ENOG4105PTM secreted protein GNE05_RS12180 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GNE05_RS12190 ENOG4105G6R Stage v sporulation protein ae GNE05_RS12200 ENOG4105CZ3 stage V sporulation protein ad GNE05_RS12205 ENOG41090VF Stage v sporulation protein ac GNE05_RS12220 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE05_RS12225 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GNE05_RS12230 ENOG41082AN stage II sporulation protein GNE05_RS12235 ENOG4105DZ1 carboxypeptidase GNE05_RS12240 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) GNE05_RS12245 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GNE05_RS12250 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GNE05_RS12260 ENOG4105I3K Ferric uptake regulator, Fur family GNE05_RS12265 ENOG4105MZ9 stage II sporulation protein m GNE05_RS12285 ENOG4105DFD Na H antiporter GNE05_RS12290 ENOG4108IJ0 Aspartate ammonia-lyase GNE05_RS12295 ENOG4105HDK L-asparaginase GNE05_RS12300 ENOG4108IMY Transcriptional regulator GNE05_RS12310 ENOG4108YZ4 nudix hydrolase GNE05_RS12320 ENOG4105CPC Aldo Keto reductase GNE05_RS12340 ENOG4106HZJ GNE05_RS12345 ENOG4105RHY Pfam:UPF0157 GNE05_RS12350 ENOG4105KAC Antibiotic biosynthesis monooxygenase GNE05_RS12355 ENOG4108XET gCN5-related N-acetyltransferase GNE05_RS12360 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GNE05_RS12375 ENOG4105C02 permease GNE05_RS12385 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase GNE05_RS12390 ENOG4105CS9 pantothenic acid kinase GNE05_RS12400 ENOG4108IXY short-chain dehydrogenase reductase GNE05_RS12405 ENOG41069FQ Metallo-beta-lactamase superfamily GNE05_RS12410 ENOG4105II7 pyrroline-5-carboxylate reductase GNE05_RS12415 ENOG4108KQ6 Enoyl-CoA hydratase GNE05_RS12420 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GNE05_RS12425 ENOG4106A3M Cytochrome p-450 GNE05_RS12440 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS12445 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS12455 ENOG4105C0W non-ribosomal peptide synthetase GNE05_RS12465 ENOG4105CHR reductase GNE05_RS12470 ENOG4105CEY Amp-dependent synthetase and ligase GNE05_RS12485 ENOG4107QKG PfaD family GNE05_RS12490 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GNE05_RS12500 ENOG4108K70 Transcriptional regulator GNE05_RS12510 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GNE05_RS12520 ENOG410861F 50S ribosomal protein L33 GNE05_RS12525 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GNE05_RS12530 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GNE05_RS12535 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GNE05_RS12540 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GNE05_RS12550 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) GNE05_RS12555 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GNE05_RS12560 ENOG4108HNZ carboxyl transferase GNE05_RS12565 ENOG4108ZVT methylmalonyl-coA epimerase GNE05_RS12575 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GNE05_RS12580 ENOG4108QEG Membrane GNE05_RS12585 ENOG4105CDA abc transporter atp-binding protein GNE05_RS12590 ENOG4105E5Q amino acid AbC transporter GNE05_RS12595 ENOG4108HW3 (ABC) transporter GNE05_RS12600 ENOG4108Y6J UPF0403 protein GNE05_RS12605 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GNE05_RS12610 ENOG4105C7S Dehydrogenase GNE05_RS12615 ENOG4105CPP Dehydrogenase, E1 component GNE05_RS12630 ENOG4105CKM Branched-chain carboxylic acid kinase GNE05_RS12635 ENOG4107RDP Dehydrogenase GNE05_RS12645 ENOG4108JUB Transcriptional regulator GNE05_RS12650 ENOG4106CCJ Protein of unknown function (DUF2627) GNE05_RS12655 ENOG4105CR4 methylisocitrate lyase GNE05_RS12660 ENOG4105DXD 2-methylcitrate dehydratase GNE05_RS12670 ENOG4105C1G acyl-Coa dehydrogenase GNE05_RS12675 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GNE05_RS12685 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GNE05_RS12690 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GNE05_RS12710 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GNE05_RS12725 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GNE05_RS12730 ENOG4107QQR Sporulation GNE05_RS12735 ENOG4105S1Z Stage IV sporulation protein B GNE05_RS12740 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GNE05_RS12745 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GNE05_RS12750 ENOG4105DX0 Hemolysin A GNE05_RS12755 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GNE05_RS12760 ENOG4105CTB Polyprenyl synthetase GNE05_RS12765 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GNE05_RS12770 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GNE05_RS12775 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GNE05_RS12780 ENOG4105M7K Involved in the transcription termination process (By similarity) GNE05_RS12785 ENOG4108ZSR alkaline shock protein GNE05_RS12790 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GNE05_RS12810 ENOG410644B Stage III sporulation protein af GNE05_RS12820 ENOG4105KQ4 Stage iii sporulation protein ad GNE05_RS12825 ENOG4108CQH stage III sporulation protein AC GNE05_RS12830 ENOG4105KR5 Stage iii sporulation protein GNE05_RS12835 ENOG4105CD2 stage iii sporulation protein aa GNE05_RS12845 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GNE05_RS12850 ENOG4105DC7 peptidase M24 GNE05_RS12860 ENOG4105CBJ Metal-dependent enzyme GNE05_RS12880 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GNE05_RS12885 ENOG4105WZW rhodanese family GNE05_RS12890 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GNE05_RS12900 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GNE05_RS12905 ENOG4105C0D helicase GNE05_RS12920 ENOG4108IMY Transcriptional regulator GNE05_RS12930 ENOG4105VFR signal peptidase GNE05_RS12990 ENOG4105C37 (CBS) domain GNE05_RS13015 ENOG4105C5X domain protein GNE05_RS13060 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GNE05_RS13065 ENOG4105WDJ 50S ribosomal protein L33 GNE05_RS13075 ENOG41068DG YceG-like family GNE05_RS13080 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GNE05_RS13085 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GNE05_RS13090 ENOG4105E2Z phosphate ABC transporter (Permease GNE05_RS13095 ENOG4105C8U phosphate abc transporter GNE05_RS13100 ENOG4105CVA phosphate GNE05_RS13105 ENOG4107RF6 penicillin-binding protein GNE05_RS13115 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GNE05_RS13120 ENOG4105SXS Protein of unknown function (DUF456) GNE05_RS13135 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GNE05_RS13140 ENOG41063Y9 GNE05_RS13145 ENOG4108U5J '-nucleotidase GNE05_RS13150 ENOG4105N80 Ferric uptake regulator, Fur family GNE05_RS13155 ENOG4108JYZ YitT family GNE05_RS13160 ENOG41069ZM Protein of unknown function (DUF2624) GNE05_RS13165 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GNE05_RS13180 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GNE05_RS13185 ENOG4105EGD dinuclear metal center protein, YbgI family GNE05_RS13200 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE05_RS13205 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GNE05_RS13210 ENOG4108UPT UPF0178 protein GNE05_RS13215 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GNE05_RS13225 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GNE05_RS13230 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GNE05_RS13235 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GNE05_RS13245 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GNE05_RS13250 ENOG4105KG3 cytidine deaminase GNE05_RS13255 ENOG4107YR5 Diacylglycerol kinase GNE05_RS13260 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GNE05_RS13265 ENOG4105CTJ Metal Dependent Phosphohydrolase GNE05_RS13270 ENOG4105C9A Phoh family GNE05_RS13275 ENOG4105EI1 sporulation protein yqfd GNE05_RS13280 ENOG41068P3 sporulation protein YqfC GNE05_RS13290 ENOG4105DI5 UPF0365 protein GNE05_RS13295 ENOG4105F7J membrane-bound serine protease GNE05_RS13300 ENOG4105KTH gatB Yqey GNE05_RS13315 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GNE05_RS13320 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GNE05_RS13325 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GNE05_RS13330 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GNE05_RS13335 ENOG4105CFG Acts as a chaperone (By similarity) GNE05_RS13340 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GNE05_RS13345 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GNE05_RS13350 ENOG4105CSA Coproporphyrinogen iii oxidase GNE05_RS13355 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GNE05_RS13365 ENOG4108ZRV stage ii sporulation protein p GNE05_RS13370 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) GNE05_RS13375 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GNE05_RS13380 ENOG4105TQK DNA polymerase iii, delta' subunit GNE05_RS13395 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GNE05_RS13400 ENOG4108UK2 deaminase GNE05_RS13405 ENOG4105KQC Competence protein GNE05_RS13415 ENOG4108D32 Methyltransferase GNE05_RS13425 ENOG4108WF2 Metal Dependent Phosphohydrolase GNE05_RS13430 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GNE05_RS13435 ENOG410812S Rna-binding protein GNE05_RS13440 ENOG4105E2X shikimate dehydrogenase GNE05_RS13445 ENOG4105CQW ribosome biogenesis GTPase YqeH GNE05_RS13450 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GNE05_RS13470 ENOG41080BT SNARE associated Golgi GNE05_RS13480 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE05_RS13495 ENOG41086D8 Transcriptional regulator GNE05_RS13500 ENOG4107V2S Transcriptional regulator GNE05_RS13515 ENOG4108SWU Histidine kinase GNE05_RS13520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE05_RS13525 ENOG4105DHF Membrane GNE05_RS13535 ENOG4108UYN gCN5-related N-acetyltransferase GNE05_RS13540 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GNE05_RS13550 ENOG4108J8C transporter major facilitator family protein GNE05_RS13560 ENOG4108U7W acetyltransferase GNE05_RS13575 ENOG4108HCJ Hydrolase GNE05_RS13580 ENOG4108HCJ Hydrolase GNE05_RS13590 ENOG4105DG6 mannose-6-phosphate isomerase GNE05_RS13595 ENOG4105DM4 PTS System GNE05_RS13610 ENOG4108Z66 YbaK ebsC protein GNE05_RS13615 ENOG4107RSM transcriptional regulator GNE05_RS13620 ENOG4105D94 Major Facilitator Superfamily GNE05_RS13625 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GNE05_RS13630 ENOG41082JN Transcriptional regulator GNE05_RS13645 ENOG4105TMB Formate nitrite transporter GNE05_RS13650 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) GNE05_RS13655 ENOG4108JB9 formate dehydrogenase GNE05_RS13670 ENOG4105C28 cystathionine GNE05_RS13700 ENOG4107XRG penicillin-binding protein GNE05_RS13705 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GNE05_RS13715 ENOG4105CFP Peptidase U32 GNE05_RS13720 ENOG4105XYU peptidase (U32 family) GNE05_RS13725 ENOG4108VQJ O-methyltransferase GNE05_RS13730 ENOG4105HHA aminodeoxychorismate lyase GNE05_RS13740 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GNE05_RS13745 ENOG4105VBH UPF0297 protein GNE05_RS13750 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GNE05_RS13755 ENOG4105C02 permease GNE05_RS13760 ENOG4105CDA abc transporter atp-binding protein GNE05_RS13765 ENOG4105CT1 (ABC) transporter GNE05_RS13770 ENOG4105EAD ABC transporter GNE05_RS13775 ENOG4105DRP amino acid AbC transporter GNE05_RS13785 ENOG41060CR GNE05_RS13795 ENOG4105C7H Helicase, RecD TraA family GNE05_RS13805 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GNE05_RS13810 ENOG4105C3J Cysteine desulfurase GNE05_RS13820 ENOG4105D1H recombination factor protein RarA GNE05_RS13825 ENOG4105CUZ uba thif-type nad fad binding protein GNE05_RS13835 ENOG4105C9M aspartyl-trna synthetase GNE05_RS13840 ENOG4105CUT histidyl-tRNA synthetase GNE05_RS13850 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GNE05_RS13855 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GNE05_RS13860 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GNE05_RS13870 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GNE05_RS13875 ENOG41067VP Protein of unknown function (DUF1049) GNE05_RS13880 ENOG4105NCW Trka-c domain protein GNE05_RS13885 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GNE05_RS13895 ENOG4105CKP Polysaccharide Biosynthesis Protein GNE05_RS13900 ENOG4108QG2 Membrane GNE05_RS13905 ENOG4105NAP GNE05_RS13910 ENOG4105VIE preprotein translocase, subunit YajC GNE05_RS13915 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GNE05_RS13920 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GNE05_RS13925 ENOG41061AI Protein of unknown function (DUF2905) GNE05_RS13930 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GNE05_RS13935 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GNE05_RS13955 ENOG4106678 morphogenetic protein associated with SpoVID GNE05_RS13960 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GNE05_RS13965 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GNE05_RS13970 ENOG4108IYU L-aspartate oxidase GNE05_RS13985 ENOG4105CQC Prephenate dehydratase GNE05_RS13995 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GNE05_RS14005 ENOG4105K46 50S ribosomal protein l27 GNE05_RS14010 ENOG4105X36 (ribosomal) protein GNE05_RS14015 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GNE05_RS14030 ENOG4107QMS site-determining protein GNE05_RS14035 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GNE05_RS14040 ENOG4105YHC Rod shape-determining protein MreD GNE05_RS14045 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GNE05_RS14050 ENOG4105DFF Rod shape-determining protein mreb GNE05_RS14055 ENOG4105W5Q DNA repair protein (RadC GNE05_RS14060 ENOG4108Z03 MAF-like protein GNE05_RS14070 ENOG4106A3R peptidase GNE05_RS14075 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GNE05_RS14080 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GNE05_RS14090 ENOG4106AR7 Spore coat protein GNE05_RS14095 ENOG41068KH stage VI sporulation protein D GNE05_RS14100 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GNE05_RS14105 ENOG4105D52 delta-aminolevulinic acid dehydratase GNE05_RS14115 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GNE05_RS14125 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GNE05_RS14135 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GNE05_RS14140 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GNE05_RS14145 ENOG4108IUQ atp-dependent protease GNE05_RS14150 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GNE05_RS14155 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GNE05_RS14165 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GNE05_RS14170 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GNE05_RS14175 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GNE05_RS14185 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GNE05_RS14190 ENOG4108ZP8 Acetolactate synthase small subunit GNE05_RS14195 ENOG4105C7K acetolactate synthase GNE05_RS14215 ENOG41082EK Restriction modification system DNA (Specificity GNE05_RS14225 ENOG4107SCJ type I restriction enzyme EcoKI subunit R GNE05_RS14250 ENOG4105M59 Phosphodiesterase, mj0936 family GNE05_RS14255 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GNE05_RS14260 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GNE05_RS14265 ENOG4108XJQ germination protein GNE05_RS14270 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GNE05_RS14275 ENOG41067TZ transcriptional regulator, MarR family GNE05_RS14280 ENOG4105PFC Transcriptional regulator GNE05_RS14290 ENOG4105E33 succinate dehydrogenase GNE05_RS14300 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GNE05_RS14310 ENOG4105CFH Aspartokinase GNE05_RS14315 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GNE05_RS14320 ENOG4105K63 Thioredoxin GNE05_RS14325 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) GNE05_RS14330 ENOG4105C10 Electron transfer flavoprotein GNE05_RS14335 ENOG4105BZJ Electron transfer flavoprotein GNE05_RS14340 ENOG41060WC Enoyl-CoA hydratase GNE05_RS14345 ENOG4107Z3H Transcriptional regulator, TetR family GNE05_RS14350 ENOG4105CEY Amp-dependent synthetase and ligase GNE05_RS14355 ENOG4108YV3 Protein of unknown function (DUF2711) GNE05_RS14365 ENOG4105C98 muts2 protein GNE05_RS14370 ENOG4105DCG PHP domain protein GNE05_RS14385 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GNE05_RS14395 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GNE05_RS14400 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GNE05_RS14405 ENOG4108RWN rrna methyltransferase GNE05_RS14410 ENOG41067MF small acid-soluble spore protein GNE05_RS14420 ENOG4105CQB FAD linked oxidase domain protein GNE05_RS14425 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GNE05_RS14435 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) GNE05_RS14440 ENOG4105DRS transport system, permease GNE05_RS14455 ENOG4108MDK Dehydrogenase GNE05_RS14465 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GNE05_RS14470 ENOG4105EF1 ribulokinase GNE05_RS14480 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase GNE05_RS14485 ENOG4105CN9 Peptidase m42 family protein GNE05_RS14495 ENOG410696E Membrane GNE05_RS14500 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GNE05_RS14505 ENOG4105VJV 50s ribosomal protein L35 GNE05_RS14510 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GNE05_RS14515 ENOG41067MG lrgb family GNE05_RS14525 ENOG4105DY9 regulatoR GNE05_RS14530 ENOG4108HRK Histidine kinase GNE05_RS14535 ENOG4105U0R haloacid dehalogenase-like hydrolase GNE05_RS14540 ENOG4105C22 threonyL-tRNA synthetase GNE05_RS14545 ENOG4108TDW sporulation protein YtxC GNE05_RS14570 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GNE05_RS14575 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GNE05_RS14580 ENOG4105KVH Transcriptional regulator GNE05_RS14585 ENOG4105F27 Major Facilitator GNE05_RS14590 ENOG4105CV8 reductase GNE05_RS14595 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GNE05_RS14605 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GNE05_RS14610 ENOG4105C2M dna polymerase I GNE05_RS14615 ENOG4105BZU Histidine kinase GNE05_RS14620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE05_RS14630 ENOG4108HMX isocitrate dehydrogenase (NADP) GNE05_RS14635 ENOG4105BZN citrate synthase GNE05_RS14640 ENOG410780I phosphoprotein phosphatase activity GNE05_RS14660 ENOG4105G7B Protein of unknown function (DUF2992) GNE05_RS14665 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GNE05_RS14675 ENOG4108REF Sporulation integral membrane protein ytvi GNE05_RS14680 ENOG4105FS0 cytoplasmic membrane protein GNE05_RS14685 ENOG4105CA9 Pyruvate kinase GNE05_RS14690 ENOG4105CTQ phosphohexokinase GNE05_RS14695 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GNE05_RS14700 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GNE05_RS14705 ENOG4105C6K Malic enzyme GNE05_RS14710 ENOG4105C0B DNA polymerase III (alpha subunit) GNE05_RS14715 ENOG4105VV2 GNE05_RS14725 ENOG4106EVM GNE05_RS14730 ENOG4105SFS phosphoesterase RecJ domain protein GNE05_RS14745 ENOG4105E8R UPF0173 metal-dependent hydrolase GNE05_RS14755 ENOG4105CH7 arginosuccinase GNE05_RS14760 ENOG4105CDH Citrulline--aspartate ligase GNE05_RS14765 ENOG4105EPU Molybdenum cofactor synthesis domain protein GNE05_RS14770 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GNE05_RS14780 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GNE05_RS14785 ENOG4105KBJ sporulation protein ytfj GNE05_RS14795 ENOG4105VK3 rdd domain containing protein GNE05_RS14800 ENOG4105D07 Signal peptide peptidase, SppA GNE05_RS14805 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GNE05_RS14810 ENOG4105EFZ amidohydrolase GNE05_RS14815 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GNE05_RS14825 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GNE05_RS14850 ENOG4105U5Y Transcriptional regulator GNE05_RS14860 ENOG4105BZU Histidine kinase GNE05_RS14870 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GNE05_RS14875 ENOG4105C26 Dehydrogenase GNE05_RS14895 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GNE05_RS14905 ENOG4108Z0Z intracellular protease Pfpi family GNE05_RS14925 ENOG4108NGU Transcriptional regulator GNE05_RS14940 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GNE05_RS14950 ENOG4105F1V Acetoin utilization protein GNE05_RS14955 ENOG4105W87 Cbs domain GNE05_RS14960 ENOG4105DGU Histone deacetylase GNE05_RS14965 ENOG4105ER2 Ompa motb domain protein GNE05_RS14970 ENOG4107R0U MotA TolQ exbB proton channel GNE05_RS14975 ENOG4105ETE Transcriptional regulator (LacI family GNE05_RS14980 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GNE05_RS15000 ENOG4105DFU Cell wall formation (By similarity) GNE05_RS15010 ENOG4108VDD TRNA binding domain protein GNE05_RS15025 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ GNE05_RS15040 ENOG4105C6K Malic enzyme GNE05_RS15045 ENOG4105C8F Beta-lactamase domain protein GNE05_RS15050 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GNE05_RS15060 ENOG4108V15 phosphotransferase enzyme family GNE05_RS15075 ENOG4107F58 2'-5' rna ligase GNE05_RS15080 ENOG4105C6T cysteine synthase GNE05_RS15085 ENOG4107QSE Dipeptidase GNE05_RS15090 ENOG4105C7N Xanthine uracil vitamin C permease GNE05_RS15105 ENOG4105YW5 deoR family transcriptional regulator GNE05_RS15120 ENOG4105CBX hi0933 family GNE05_RS15125 ENOG4105C94 Transporter GNE05_RS15150 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GNE05_RS15155 ENOG4105I1K ABC transporter GNE05_RS15170 ENOG41085GJ domain protein GNE05_RS15175 ENOG4105C8T Leucyl-tRNA synthetase GNE05_RS15185 ENOG4105BZU Histidine kinase GNE05_RS15195 ENOG410605W Major Facilitator GNE05_RS15210 ENOG4105C19 ABC transporter GNE05_RS15215 ENOG4105EWM Histidine kinase GNE05_RS15225 ENOG4107R34 abc transporter permease protein GNE05_RS15230 ENOG4105C19 ABC transporter GNE05_RS15250 ENOG4105DVE abc transporter atp-binding protein GNE05_RS15255 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GNE05_RS15275 ENOG4105N5T Radical SAM Protein GNE05_RS15290 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GNE05_RS15300 ENOG4105E8V Alpha Beta Hydrolase Fold protein GNE05_RS15305 ENOG4108Z0R Transferase GNE05_RS15310 ENOG4105C85 amino acid GNE05_RS15315 ENOG4105CAQ asparagine synthetase GNE05_RS15320 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GNE05_RS15325 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GNE05_RS15340 ENOG4105D2X ABC transporter substrate-binding protein GNE05_RS15350 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GNE05_RS15365 ENOG4108RMU ferritin dps family protein GNE05_RS15380 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GNE05_RS15385 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GNE05_RS15390 ENOG4108V2W Carbonate dehydratase GNE05_RS15395 ENOG4105NRA 50s ribosomal protein l31 type b GNE05_RS15415 ENOG4105CC5 ABC transporter GNE05_RS15420 ENOG4105CC5 ABC transporter GNE05_RS15425 ENOG4105DIK (ABC) transporter GNE05_RS15430 ENOG4105DSE periplasmic solute binding protein GNE05_RS15435 ENOG4105DTQ mandelate racemase muconate lactonizing GNE05_RS15440 ENOG4105CEY Amp-dependent synthetase and ligase GNE05_RS15445 ENOG4108IPT Naphthoate synthase GNE05_RS15450 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GNE05_RS15455 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GNE05_RS15460 ENOG4105E4F Isochorismate synthase GNE05_RS15595 ENOG4105N67 Proton-coupled thiamine transporter YuaJ GNE05_RS15655 ENOG4105E4C Lytic transglycosylase catalytic GNE05_RS15730 ENOG41068G1 GNE05_RS15765 ENOG4105ZUG GNE05_RS15790 ENOG4107D0N GNE05_RS15815 ENOG4106DF1 GNE05_RS15820 ENOG4108VNY MOSC domain protein GNE05_RS15825 ENOG4108JB8 alcohol dehydrogenase GNE05_RS15830 ENOG4105C26 Dehydrogenase GNE05_RS15835 ENOG4105TRT Transcriptional regulator GNE05_RS15850 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GNE05_RS15855 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GNE05_RS15875 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GNE05_RS15885 ENOG4105EE0 oxidoreductase GNE05_RS15890 ENOG4108Z0Z intracellular protease Pfpi family GNE05_RS15895 ENOG4105C8Q Methyl-accepting chemotaxis GNE05_RS15900 ENOG4105C8Q Methyl-accepting chemotaxis GNE05_RS15905 ENOG4105C8Q Methyl-accepting chemotaxis GNE05_RS15910 ENOG4105C8Q Methyl-accepting chemotaxis GNE05_RS15925 ENOG4105EA8 2-Nitropropane dioxygenase GNE05_RS15930 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GNE05_RS15940 ENOG4105C37 (CBS) domain GNE05_RS15955 ENOG4107PBV potassium channel GNE05_RS15960 ENOG4107PBV potassium channel GNE05_RS15975 ENOG4107QYV phosphohexose isomerase GNE05_RS15985 ENOG4105CHJ isochorismatase hydrolase GNE05_RS15995 ENOG4107QW4 alcohol dehydrogenase GNE05_RS16000 ENOG4105WG9 Conserved Protein GNE05_RS16010 ENOG4105CHM Aminotransferase GNE05_RS16015 ENOG4108ZB6 transcriptional regulator AsnC family GNE05_RS16020 ENOG4108MUZ hydrolase GNE05_RS16030 ENOG4105C87 Aminotransferase class I and II GNE05_RS16035 ENOG4108HGU Histidine kinase GNE05_RS16040 ENOG4105Y38 Kinase-associated protein B GNE05_RS16055 ENOG4105BZ4 penicillin-binding protein GNE05_RS16060 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GNE05_RS16075 ENOG4108MRH transcriptional regulatory protein GNE05_RS16080 ENOG4105DIH basic membrane GNE05_RS16085 ENOG4108JQ9 ABC transporter GNE05_RS16090 ENOG4105UIB (ABC) transporter GNE05_RS16105 ENOG4105D65 subunit l GNE05_RS16110 ENOG4105HC0 Na H antiporter GNE05_RS16115 ENOG4108ZE9 Monovalent cation H antiporter subunit C GNE05_RS16120 ENOG4108JPZ Monovalent cation H antiporter subunit D GNE05_RS16125 ENOG4105SC1 monovalent cation H antiporter subunit E GNE05_RS16135 ENOG4105KJM monovalent cation h antiporter subunit g GNE05_RS16140 ENOG4105KA0 thioesterase Superfamily protein GNE05_RS16150 ENOG4105BZU Histidine kinase GNE05_RS16175 ENOG4105D58 Diguanylate phosphodiesterase GNE05_RS16180 ENOG4105DAP Nicotinate phosphoribosyltransferase GNE05_RS16205 ENOG4105C02 permease GNE05_RS16220 ENOG410904N short-chain dehydrogenase reductase GNE05_RS16255 ENOG4108K8K Transcriptional regulator GNE05_RS16260 ENOG4105DCF alanine dehydrogenase GNE05_RS16270 ENOG4105WQT MbtH domain protein GNE05_RS16275 ENOG4105CEY Amp-dependent synthetase and ligase GNE05_RS16280 ENOG4105WQI isochorismatase GNE05_RS16285 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GNE05_RS16290 ENOG4105E4F Isochorismate synthase GNE05_RS16295 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GNE05_RS16300 ENOG4105NIV Esterase GNE05_RS16320 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GNE05_RS16330 ENOG41069ER domain protein GNE05_RS16345 ENOG4105CEP NADH dehydrogenase GNE05_RS16355 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) GNE05_RS16370 ENOG4105CJ1 ABC, transporter GNE05_RS16390 ENOG4105D9U N-acetyltransferase GNE05_RS16395 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GNE05_RS16400 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GNE05_RS16405 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GNE05_RS16415 ENOG4105ZKE UPF0349 protein GNE05_RS16430 ENOG41083MR nifu domain-containing protein GNE05_RS16435 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GNE05_RS16440 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GNE05_RS16445 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GNE05_RS16450 ENOG4105D6E homoserine dehydrogenase GNE05_RS16460 ENOG4108W5N phosphatidylglycerophosphatase a GNE05_RS16465 ENOG4105D4U had-superfamily hydrolase, subfamily iia GNE05_RS16475 ENOG4105MMD transcriptional regulator GNE05_RS16480 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GNE05_RS16485 ENOG4105FAA peptidase M23 GNE05_RS16490 ENOG4108YTE sporulation protein YunB GNE05_RS16495 ENOG4107R8B 5'-nucleotidase GNE05_RS16505 ENOG4105I3N Conserved Protein GNE05_RS16515 ENOG4105CD3 dihydroorotase GNE05_RS16520 ENOG4105G9B Transcriptional regulator GNE05_RS16550 ENOG4105C5R Aminotransferase GNE05_RS16560 ENOG4108K8S endonuclease I GNE05_RS16565 ENOG4108IJ9 (ABC) transporter GNE05_RS16570 ENOG4105FDP GntR family transcriptional regulator GNE05_RS16575 ENOG4108KPW sugar kinase GNE05_RS16580 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GNE05_RS16585 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GNE05_RS16590 ENOG4105XN3 extracellular solute-binding protein family 1 GNE05_RS16595 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine GNE05_RS16625 ENOG4105PKS Excinuclease abc c subunit domain protein GNE05_RS16630 ENOG4107VFR oxidoreductase GNE05_RS16635 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GNE05_RS16645 ENOG41083Q9 chitosanase GNE05_RS16650 ENOG4105DIW FeS assembly protein SUFB GNE05_RS16655 ENOG4108UNV SUF system FeS assembly protein, NifU family GNE05_RS16660 ENOG4105C9B Cysteine desulfurase GNE05_RS16665 ENOG4105JRK feS assembly protein SufD GNE05_RS16670 ENOG4105C3K feS assembly ATPase SufC GNE05_RS16685 ENOG4105D01 (LipO)protein GNE05_RS16690 ENOG4108UMI ABC transporter, permease GNE05_RS16695 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GNE05_RS16720 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GNE05_RS16725 ENOG41080E8 Transcriptional regulator, Spx MgsR family GNE05_RS16730 ENOG4105C1G acyl-Coa dehydrogenase GNE05_RS16735 ENOG4105CHU acetyl-coa acetyltransferase GNE05_RS16765 ENOG41067TZ transcriptional regulator, MarR family GNE05_RS16770 ENOG4105C0R drug resistance transporter emrb qaca subfamily GNE05_RS16775 ENOG4105DND Transcriptional regulator GNE05_RS16795 ENOG4105E0A ABC, transporter GNE05_RS16810 ENOG4105E1F short-chain dehydrogenase reductase GNE05_RS16815 ENOG4105HUF DNA protection during starvation protein GNE05_RS16820 ENOG4105C0H protease GNE05_RS16830 ENOG4105F3H Histidine kinase GNE05_RS16840 ENOG41067SE Tetr family transcriptional regulator GNE05_RS16845 ENOG4105C9Q fumarate hydratase class II GNE05_RS16870 ENOG4105WH1 Two component transcriptional regulator luxr family GNE05_RS16875 ENOG4105ENE Histidine kinase GNE05_RS16890 ENOG41087YS Phage shock protein A GNE05_RS16905 ENOG4108WBT adenosyltransferase GNE05_RS16910 ENOG4105E0A ABC, transporter GNE05_RS16915 ENOG4105EHG Permease protein GNE05_RS16920 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GNE05_RS16925 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GNE05_RS16930 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GNE05_RS16940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE05_RS16950 ENOG4106DF4 Sigma-70, region 4 GNE05_RS16960 ENOG4105F0F Oxalate decarboxylase GNE05_RS16970 ENOG4105E0A ABC, transporter GNE05_RS16975 ENOG4105EHG Permease protein GNE05_RS16980 ENOG4105DQ5 transport system permease protein GNE05_RS16990 ENOG4105JQZ Methyltransferase GNE05_RS16995 ENOG4105D5Q Arginine ornithine antiporter GNE05_RS17005 ENOG4107K5X Membrane-bound metal-dependent hydrolase GNE05_RS17010 ENOG4107QZ2 Sulfatase GNE05_RS17015 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GNE05_RS17020 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GNE05_RS17025 ENOG4105E0C molybdate abc transporter GNE05_RS17030 ENOG4105WH1 Two component transcriptional regulator luxr family GNE05_RS17035 ENOG4105BZU Histidine kinase GNE05_RS17040 ENOG4105CJ1 ABC, transporter GNE05_RS17050 ENOG4108KYE ABC-2 type transporter GNE05_RS17065 ENOG4105EEQ Na H antiporter GNE05_RS17070 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GNE05_RS17075 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GNE05_RS17080 ENOG4105EEM helicase GNE05_RS17085 ENOG4105EN6 Membrane GNE05_RS17100 ENOG4107ZQN disulfide bond GNE05_RS17105 ENOG4105C59 p-type ATPase GNE05_RS17110 ENOG4105C59 p-type ATPase GNE05_RS17115 ENOG410681U heavy metal transport detoxification protein GNE05_RS17120 ENOG4105VPX protein, conserved in bacteria GNE05_RS17125 ENOG4105D9R oxidoreductase GNE05_RS17130 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GNE05_RS17145 ENOG4105DEN Luciferase family GNE05_RS17150 ENOG4105CDA abc transporter atp-binding protein GNE05_RS17175 ENOG4108XSB acetyltransferase, (GNAT) family GNE05_RS17180 ENOG4108KSA LysR family transcriptional regulator GNE05_RS17185 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GNE05_RS17190 ENOG41067XF inhibitor GNE05_RS17195 ENOG41067XF inhibitor GNE05_RS17205 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GNE05_RS17210 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GNE05_RS17220 ENOG4105XZU Preprotein translocase, subunit SecG GNE05_RS17240 ENOG4105KVH Transcriptional regulator GNE05_RS17265 ENOG4105DA5 (ABC) transporter GNE05_RS17305 ENOG4105R40 Glycine betaine carnitine choline GNE05_RS17310 ENOG4108HQR Glycine betaine GNE05_RS17315 ENOG4105E90 ABC transporter GNE05_RS17320 ENOG4108IJ8 ABC transporter GNE05_RS17325 ENOG4107HG4 Transcriptional regulator GNE05_RS17330 ENOG4105R40 Glycine betaine carnitine choline GNE05_RS17335 ENOG4108HQR Glycine betaine GNE05_RS17340 ENOG4105E90 ABC transporter GNE05_RS17345 ENOG4108IJ8 ABC transporter GNE05_RS17350 ENOG4107HG4 Transcriptional regulator GNE05_RS17355 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GNE05_RS17365 ENOG4105T65 Membrane-associated protein GNE05_RS17370 ENOG4108W0I acetyltransferase GNE05_RS17375 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GNE05_RS17380 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GNE05_RS17385 ENOG4105CP7 Triose-phosphate isomerase GNE05_RS17390 ENOG4105BZA Phosphoglycerate kinase GNE05_RS17395 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GNE05_RS17410 ENOG4105CMD Transcriptional regulator, GntR family GNE05_RS17415 ENOG4105DEN Luciferase family GNE05_RS17420 ENOG4105GZI Transcriptional regulator GNE05_RS17425 ENOG4107RT3 EamA-like transporter family GNE05_RS17435 ENOG4106KNT transcriptional regulator GNE05_RS17440 ENOG4105CMG Carbohydrate kinase GNE05_RS17445 ENOG4105C6Z Gluconate GNE05_RS17455 ENOG4107QR9 Iron-sulfur cluster binding protein GNE05_RS17460 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GNE05_RS17465 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNE05_RS17470 ENOG4105JXH GntR family transcriptional regulator GNE05_RS17475 ENOG4105DAA L-lactate GNE05_RS17480 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE05_RS17490 ENOG4108ZPC Polysaccharide pyruvyl transferase GNE05_RS17495 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GNE05_RS17500 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family GNE05_RS17505 ENOG4105D3Q Sugar transferase GNE05_RS17515 ENOG4105K64 Glycosyl transferase, family 2 GNE05_RS17525 ENOG4107QRS glycosyltransferase group 2 family protein GNE05_RS17530 ENOG41068W6 Capsular polysaccharide biosynthesis protein GNE05_RS17535 ENOG4108KMV Glycosyl transferase (Group 1 GNE05_RS17540 ENOG4105K64 Glycosyl transferase, family 2 GNE05_RS17545 ENOG4108PQP glycosyl transferase group 1 GNE05_RS17555 ENOG4108QV3 biosynthesis protein GNE05_RS17560 ENOG4105HTX biosynthesis protein GNE05_RS17570 ENOG4105EBR Carboxylesterase GNE05_RS17580 ENOG4105NAE bifunctional deaminase-reductase domain protein GNE05_RS17590 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GNE05_RS17595 ENOG4105PY6 Phenolic acid decarboxylase GNE05_RS17600 ENOG4105NI3 Protein of unknown function (DUF3237) GNE05_RS17630 ENOG4108HKT sucrose-6-phosphate hydrolase GNE05_RS17635 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GNE05_RS17640 ENOG4105ETE Transcriptional regulator (LacI family GNE05_RS17645 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GNE05_RS17650 ENOG4107URF beta-phospho-glucomutase GNE05_RS17655 ENOG4105CG3 alpha amylase, catalytic region GNE05_RS17670 ENOG4105EG2 ABC transporter, permease GNE05_RS17675 ENOG4105D56 permease protein GNE05_RS17680 ENOG4107FKK extracellular solute-binding protein family 1 GNE05_RS17685 ENOG4108IUK alpha amylase, catalytic GNE05_RS17690 ENOG4105FKQ transcriptional regulator GNE05_RS17695 ENOG4108URH decarboxylase GNE05_RS17700 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain GNE05_RS17705 ENOG4105CHH sulfate transporter GNE05_RS17710 ENOG4108V2W Carbonate dehydratase GNE05_RS17715 ENOG4105C5I Dehydrogenase GNE05_RS17720 ENOG4105GGE ribonuclease GNE05_RS17725 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GNE05_RS17730 ENOG4105KRI phosphocarrier protein (HPr GNE05_RS17735 ENOG4105CIE May be required for sporulation (By similarity) GNE05_RS17740 ENOG4105CHW UPF0052 protein GNE05_RS17745 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GNE05_RS17750 ENOG4108Z4K mutator MutT protein GNE05_RS17755 ENOG4105C3M thioredoxin reductase GNE05_RS17770 ENOG4105BZU Histidine kinase GNE05_RS17775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE05_RS17780 ENOG4105BZ1 (ABC) transporter GNE05_RS17785 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GNE05_RS17790 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GNE05_RS17795 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GNE05_RS17800 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GNE05_RS17805 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GNE05_RS17810 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GNE05_RS17815 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GNE05_RS17820 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GNE05_RS17830 ENOG4108S4C acetyltransferase GNE05_RS17835 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GNE05_RS17845 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GNE05_RS17850 ENOG4105CE4 GlcNAc 6-P deacetylase GNE05_RS17855 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GNE05_RS17860 ENOG4105FDP GntR family transcriptional regulator GNE05_RS17865 ENOG4105J7D transcriptional regulator GNE05_RS17870 ENOG41088CQ domain protein GNE05_RS17875 ENOG41086DT Membrane protein of unknown function GNE05_RS17880 ENOG41067S9 phage shock protein C, PspC GNE05_RS17885 ENOG4108PY7 GNE05_RS17900 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GNE05_RS17905 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GNE05_RS17920 ENOG4105MKU Transcriptional regulator GNE05_RS17950 ENOG4105CN1 protease GNE05_RS17955 ENOG4108M26 parallel beta-helix repeat protein GNE05_RS17960 ENOG4105CRP Part of the ABC transporter FtsEX involved in GNE05_RS17965 ENOG4105CAK Cell division ATP-binding protein ftsE GNE05_RS17985 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GNE05_RS17990 ENOG4105MS2 ribosomal subunit Interface protein GNE05_RS18005 ENOG4105MQ3 flagellar protein FliS GNE05_RS18010 ENOG4107RT6 flagellar hook-associated GNE05_RS18015 ENOG4105I03 Flagellin GNE05_RS18020 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GNE05_RS18025 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GNE05_RS18035 ENOG4105DTJ flagellar hook-associated protein GNE05_RS18040 ENOG4105E1Q flagellar hook-associated protein GNE05_RS18055 ENOG4105RU3 GNE05_RS18060 ENOG41081UC Inherit from COG: Competence protein GNE05_RS18080 ENOG4105WH1 Two component transcriptional regulator luxr family GNE05_RS18085 ENOG4105BZU Histidine kinase GNE05_RS18090 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GNE05_RS18095 ENOG4108KGH TRANSCRIPTIONal GNE05_RS18100 ENOG4105ESV Glycosyl transferase, family 4 GNE05_RS18105 ENOG4107EF8 Glycosyl transferase (Group 1 GNE05_RS18120 ENOG4105QZI O-Antigen Polymerase GNE05_RS18125 ENOG4105C6Y Udp-glucose 6-dehydrogenase GNE05_RS18130 ENOG4107RA4 Glycosyl transferase (Group 1 GNE05_RS18135 ENOG4105PSV Polysaccharide Biosynthesis Protein GNE05_RS18140 ENOG4105D3Q Sugar transferase GNE05_RS18145 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GNE05_RS18150 ENOG4105JFG SpoIID LytB domain protein GNE05_RS18160 ENOG4108KGH TRANSCRIPTIONal GNE05_RS18165 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GNE05_RS18170 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GNE05_RS18175 ENOG4105EY8 ABC transporter GNE05_RS18190 ENOG4107SJB teichoic acid biosynthesis GNE05_RS18195 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) GNE05_RS18200 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase GNE05_RS18210 ENOG4107RZX Teichoic acid biosynthesis protein GNE05_RS18220 ENOG4105DG6 mannose-6-phosphate isomerase GNE05_RS18235 ENOG4108NHD germination protein GNE05_RS18240 ENOG4107R8N Glycosyl transferase, family 2 GNE05_RS18245 ENOG4105C54 Major Facilitator superfamily GNE05_RS18250 ENOG4108KGH TRANSCRIPTIONal GNE05_RS18255 ENOG4105J7I hydrolase GNE05_RS18260 ENOG4106UBQ GNE05_RS18265 ENOG4105K4H Nlp p60 protein GNE05_RS18275 ENOG4105PNM synthesis protein GNE05_RS18285 ENOG4105N98 Capsule biosynthesis protein capB GNE05_RS18290 ENOG4105E1K spore germination protein GNE05_RS18305 ENOG4105ETE Transcriptional regulator (LacI family GNE05_RS18310 ENOG4108RVA ribokinase GNE05_RS18315 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GNE05_RS18320 ENOG4105C2J ABC transporter GNE05_RS18325 ENOG4105CNN ABC, transporter GNE05_RS18330 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GNE05_RS18340 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GNE05_RS18345 ENOG4107FQX Alpha-acetolactate decarboxylase GNE05_RS18355 ENOG4107RSM transcriptional regulator GNE05_RS18370 ENOG4106UIA GNE05_RS18385 ENOG4107XC4 flavin reductase domain protein, FMN-binding GNE05_RS18395 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GNE05_RS18405 ENOG4105CAH Chromate GNE05_RS18410 ENOG4105FGV Chromate GNE05_RS18420 ENOG4108WS4 fmn reductase GNE05_RS18425 ENOG4107V2S Transcriptional regulator GNE05_RS18430 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GNE05_RS18490 ENOG4108XI2 Domain of unknown function (DUF1963) GNE05_RS18495 ENOG4105C6Y Udp-glucose 6-dehydrogenase GNE05_RS18500 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GNE05_RS18505 ENOG4107YJ4 chain length determinant protein GNE05_RS18510 ENOG4105HTX biosynthesis protein GNE05_RS18520 ENOG4105KBK Zinc finger, swim domain protein GNE05_RS18525 ENOG4105C0D helicase GNE05_RS18530 ENOG410667J hydrolase GNE05_RS18535 ENOG4105E98 transcriptional regulator DeoR family GNE05_RS18540 ENOG4105Z8H single-stranded DNA-binding protein GNE05_RS18555 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GNE05_RS18560 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GNE05_RS18570 ENOG4105CGA flagellar basal-body rod protein FlgG GNE05_RS18580 ENOG4105DFF Rod shape-determining protein mreb GNE05_RS18585 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GNE05_RS18590 ENOG4107MII Sugar-specific transcriptional regulator TrmB GNE05_RS18595 ENOG4105CZM Major Facilitator GNE05_RS18600 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GNE05_RS18605 ENOG41080V3 Major Facilitator superfamily GNE05_RS18610 ENOG4105D3W isochorismatase GNE05_RS18615 ENOG4105BZU Histidine kinase GNE05_RS18625 ENOG4105CNI cell division protein FtsW GNE05_RS18630 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GNE05_RS18640 ENOG4105FRN stage II sporulation protein GNE05_RS18645 ENOG4107TCE N-acetyltransferase GNE05_RS18660 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GNE05_RS18665 ENOG4106BRK GNE05_RS18670 ENOG4107T94 Endo-14-beta-xylanase GNE05_RS18675 ENOG4108Z40 Transcriptional regulator GNE05_RS18680 ENOG4105CQM Urea amidohydrolase subunit alpha GNE05_RS18685 ENOG4105KI2 Urea amidohydrolase subunit beta GNE05_RS18690 ENOG4108YZ9 Urea amidohydrolase subunit gamma GNE05_RS18710 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GNE05_RS18715 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GNE05_RS18720 ENOG4108TF4 von Willebrand factor, type A GNE05_RS18735 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GNE05_RS18745 ENOG4106778 Protein of unknown function (DUF1146) GNE05_RS18755 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GNE05_RS18760 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GNE05_RS18765 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GNE05_RS18770 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GNE05_RS18775 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GNE05_RS18790 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GNE05_RS18800 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GNE05_RS18805 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GNE05_RS18810 ENOG4108UIC UPF0340 protein GNE05_RS18815 ENOG4108YZG isomerase GNE05_RS18820 ENOG4107WAU Protein tyrosine phosphatase GNE05_RS18825 ENOG410815N Probably functions as a manganese efflux pump (By similarity) GNE05_RS18830 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GNE05_RS18840 ENOG4108ZXQ stage ii sporulation protein r GNE05_RS18855 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GNE05_RS18860 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GNE05_RS18865 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GNE05_RS18875 ENOG4107TT2 Auxin Efflux Carrier GNE05_RS18880 ENOG4105C6K Malic enzyme GNE05_RS18885 ENOG4107104 thymidine kinase GNE05_RS18890 ENOG41082DI 50s ribosomal protein l31 GNE05_RS18895 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GNE05_RS18900 ENOG4105CBT Fructose-1,6-bisphosphatase GNE05_RS18905 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GNE05_RS18915 ENOG4105D2N Aldolase GNE05_RS18920 ENOG410812K response regulator receiver protein GNE05_RS18930 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GNE05_RS18940 ENOG4105DF6 Fe-S oxidoreductase GNE05_RS18950 ENOG4105E5J UV damage endonuclease GNE05_RS18960 ENOG4105BZ1 (ABC) transporter GNE05_RS18965 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GNE05_RS18980 ENOG4105R3A Nitrate reductase GNE05_RS18985 ENOG4108IUE nitrate reductase beta subunit GNE05_RS19005 ENOG4107V6Q Cyclic nucleotide-binding domain GNE05_RS19015 ENOG4105C75 arginyL-tRNA synthetase GNE05_RS19020 ENOG410684U Domain of unknown function (DUF1934) GNE05_RS19025 ENOG4107JM4 Tetratricopeptide repeat GNE05_RS19070 ENOG4105CYW agmatinase GNE05_RS19075 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GNE05_RS19080 ENOG4105BZ4 penicillin-binding protein GNE05_RS19090 ENOG4108XFG YwhD family GNE05_RS19095 ENOG4108Z4T Peptidase M50 GNE05_RS19100 ENOG41069HH 4-oxalocrotonate tautomerase GNE05_RS19105 ENOG41067TZ transcriptional regulator, MarR family GNE05_RS19115 ENOG4105CUB amino acid GNE05_RS19125 ENOG4105DCI Phosphohydrolase GNE05_RS19135 ENOG4108VCI transcription factor, rsfa family GNE05_RS19140 ENOG4105K7K Transcriptional regulator GNE05_RS19150 ENOG4105CJ1 ABC, transporter GNE05_RS19155 ENOG4108TU7 Inherit from COG: (ABC) transporter GNE05_RS19180 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GNE05_RS19185 ENOG4105DUM transcriptional regulator, lysR family GNE05_RS19190 ENOG4105HMI Membrane GNE05_RS19195 ENOG4108IJ2 phosphate acetyltransferase GNE05_RS19200 ENOG4107JTW chlorite dismutase GNE05_RS19225 ENOG4105K63 Thioredoxin GNE05_RS19235 ENOG4105CHM Aminotransferase GNE05_RS19265 ENOG4105FCW Major Facilitator superfamily GNE05_RS19270 ENOG4105C2C drug resistance transporter, Bcr CflA GNE05_RS19285 ENOG4105C26 Dehydrogenase GNE05_RS19290 ENOG4105D82 Glutamate dehydrogenase GNE05_RS19300 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE05_RS19320 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase GNE05_RS19325 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GNE05_RS19330 ENOG4105C1B dTDP-glucose 4-6-dehydratase GNE05_RS19335 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GNE05_RS19340 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG GNE05_RS19345 ENOG4107TY6 Acylneuraminate cytidylyltransferase GNE05_RS19355 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD GNE05_RS19360 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GNE05_RS19395 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GNE05_RS19400 ENOG4108RJ9 Glycosyl transferase, family 2 GNE05_RS19420 ENOG4105DWF phosphomethylpyrimidine kinase GNE05_RS19435 ENOG4105C5Y PTS System GNE05_RS19450 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GNE05_RS19455 ENOG4105DEN Luciferase family GNE05_RS19460 ENOG4108DBC nitroreductase GNE05_RS19470 ENOG4105I4A GCN5-related N-acetyltransferase GNE05_RS19490 ENOG4105BZ9 Cytochrome C oxidase, subunit I GNE05_RS19495 ENOG4105E2S oxidase) subunit II GNE05_RS19500 ENOG4107BMA Transglycosylase associated protein GNE05_RS19515 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GNE05_RS19520 ENOG4105WH5 Teichoic acid glycosylation protein GNE05_RS19545 ENOG4107ZXU DSBA oxidoreductase GNE05_RS19550 ENOG4105DBE peroxidase GNE05_RS19555 ENOG410650H (LipO)protein GNE05_RS19560 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GNE05_RS19565 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GNE05_RS19570 ENOG4105CMU LysR family (Transcriptional regulator GNE05_RS19575 ENOG4105VAW lrga family GNE05_RS19580 ENOG41067MG lrgb family GNE05_RS19590 ENOG4107TXC Transcriptional regulator GNE05_RS19600 ENOG4105DR4 Methyltransferase GNE05_RS19610 ENOG4105CK1 PTS System GNE05_RS19615 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin GNE05_RS19620 ENOG4105X1N Glycosyl transferase family 8 GNE05_RS19625 ENOG4105GVJ transcriptional regulator GNE05_RS19630 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GNE05_RS19640 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GNE05_RS19650 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) GNE05_RS19655 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GNE05_RS19660 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) GNE05_RS19665 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GNE05_RS19670 ENOG4105CM2 brancheD-chain amino acid aminotransferase GNE05_RS19675 ENOG4105F8D glycoside hydrolase family 4 GNE05_RS19680 ENOG4105VCP PTS System GNE05_RS19685 ENOG4105CK1 PTS System GNE05_RS19690 ENOG4105VZJ PTS System GNE05_RS19695 ENOG4105EMD TRANSCRIPTIONal GNE05_RS19705 ENOG4105DQ5 transport system permease protein GNE05_RS19710 ENOG4105EHG Permease protein GNE05_RS19720 ENOG41082YX Transcriptional regulator, arsr family GNE05_RS19725 ENOG4107R5R arsenical pump membrane protein GNE05_RS19730 ENOG4105VZJ PTS System GNE05_RS19735 ENOG4105VCP PTS System GNE05_RS19740 ENOG4105CK1 PTS System GNE05_RS19745 ENOG4105CS2 ec 3.2.1.21 GNE05_RS19750 ENOG4105EVU fructokinase GNE05_RS19755 ENOG4105DG6 mannose-6-phosphate isomerase GNE05_RS19765 ENOG4105CH6 catalase GNE05_RS19770 ENOG4107QHE Choloylglycine hydrolase GNE05_RS19775 ENOG4105ETS cytosine purines uracil thiamine allantoin GNE05_RS19780 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GNE05_RS19785 ENOG4108JJ8 (ABC) transporter GNE05_RS19790 ENOG4108JJ9 ABC, transporter GNE05_RS19795 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GNE05_RS19800 ENOG4105C4M (Ubiquinol oxidase) subunit I GNE05_RS19805 ENOG4105D2K citrate carrier protein GNE05_RS19810 ENOG4107BJW polysaccharide deacetylase GNE05_RS19825 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GNE05_RS19835 ENOG4105CMR udp-glucose 4-epimerase GNE05_RS19840 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GNE05_RS19855 ENOG4105DHI Methyltransferase GNE05_RS19875 ENOG4105CH6 catalase GNE05_RS19880 ENOG4105D4T Citrate transporter GNE05_RS19890 ENOG4105CID antiterminator GNE05_RS19895 ENOG4105DEU major facilitator superfamily GNE05_RS19900 ENOG4105C1J atp-dependent rna helicase GNE05_RS19960 ENOG4108NR7 pectate lyase GNE05_RS19970 ENOG4107YZX Universal stress protein GNE05_RS20030 ENOG4106Z5D Glycoside Hydrolase Family 43 GNE05_RS20040 ENOG4105C84 Histidine ammonia-lyase GNE05_RS20045 ENOG4105CGP Urocanate hydratase GNE05_RS20050 ENOG4105CI2 imidazolone-5-propionate hydrolase GNE05_RS20055 ENOG4107W25 arginase agmatinase formiminoglutamase GNE05_RS20065 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GNE05_RS20070 ENOG4105D9N nucleoside GNE05_RS20075 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GNE05_RS20080 ENOG4107RHR regulatoR GNE05_RS20085 ENOG410667J hydrolase GNE05_RS20115 ENOG4108V5C ABC transporter GNE05_RS20150 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE05_RS20175 ENOG4105WZ4 isomerase GNE05_RS20180 ENOG4105F0H myo-inositol catabolism protein GNE05_RS20185 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GNE05_RS20195 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GNE05_RS20205 ENOG4105EDK PfkB domain protein GNE05_RS20215 ENOG4105C26 Dehydrogenase GNE05_RS20225 ENOG4105CPC Aldo Keto reductase GNE05_RS20230 ENOG4107QNK )-transporter GNE05_RS20235 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GNE05_RS20245 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GNE05_RS20250 ENOG4108S01 response regulator GNE05_RS20255 ENOG4108ZGX Histidine kinase GNE05_RS20260 ENOG4105ECK Fatty Acid Desaturase GNE05_RS20270 ENOG4105ST3 Transcriptional regulator GNE05_RS20275 ENOG4105C26 Dehydrogenase GNE05_RS20280 ENOG4108ITS PQQ enzyme repeat GNE05_RS20290 ENOG4105WAB arsR family transcriptional regulator GNE05_RS20295 ENOG4105F27 Major Facilitator GNE05_RS20300 ENOG41085PJ rdd domain containing protein GNE05_RS20310 ENOG4105D0M Protease HtpX homolog GNE05_RS20315 ENOG4106H3A restriction GNE05_RS20320 ENOG4105D3R alkyl hydroperoxide reductase GNE05_RS20325 ENOG4108JU3 Alkyl hydroperoxide reductase GNE05_RS20330 ENOG4107R3N Filamentation induced by cAMP protein fic GNE05_RS20335 ENOG4105C85 amino acid GNE05_RS20340 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 GNE05_RS20345 ENOG4108XHQ (2Fe-2S)-binding domain protein GNE05_RS20365 ENOG4105XRQ Xanthine dehydrogenase accessory factor GNE05_RS20405 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GNE05_RS20420 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) GNE05_RS20425 ENOG4105CPC Aldo Keto reductase GNE05_RS20430 ENOG4105WQG acetyltransferase GNE05_RS20440 ENOG41066UZ arginase EC 3.5.3.1 GNE05_RS20445 ENOG4108IQI permease GNE05_RS20450 ENOG4105C8Y Acetylornithine aminotransferase GNE05_RS20460 ENOG41082BM Transcriptional regulator, arsr family GNE05_RS20465 ENOG4108JUB Transcriptional regulator GNE05_RS20475 ENOG4105C5H ABC transporter GNE05_RS20490 ENOG4105D06 uba thif-type nad fad binding protein GNE05_RS20495 ENOG41062D9 Histidine kinase GNE05_RS20510 ENOG4105C0H protease GNE05_RS20515 ENOG4105Q2H domain protein GNE05_RS20530 ENOG4105BZU Histidine kinase GNE05_RS20535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE05_RS20560 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GNE05_RS20565 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GNE05_RS20570 ENOG4105CDU Replicative dna helicase GNE05_RS20590 ENOG4105EDW glycosyl transferase, family 39 GNE05_RS20605 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GNE05_RS20610 ENOG4105CPK Glycosyl transferase (Group 1 GNE05_RS20630 ENOG4105BZR domain protein GNE05_RS20635 ENOG4108XMW Membrane GNE05_RS20650 ENOG4105KVH Transcriptional regulator GNE05_RS20655 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GNE05_RS20660 ENOG4108UZ3 Transporter GNE05_RS20665 ENOG4105EDQ levansucrase EC 2.4.1.10 GNE05_RS20670 ENOG4108HKT sucrose-6-phosphate hydrolase GNE05_RS20690 ENOG4106UX7 integral membrane protein GNE05_RS20700 ENOG4108TVJ Nitroreductase GNE05_RS20705 ENOG4105FS7 Transcriptional regulator GNE05_RS20715 ENOG4108U05 Transcriptional regulator GNE05_RS20720 ENOG41082BV acetyltransferase GNE05_RS20730 ENOG4107XGZ Hydrolase GNE05_RS20775 ENOG4107Y9U Membrane GNE05_RS20780 ENOG4105C7Z Conserved Protein GNE05_RS20785 ENOG4107FCW Abortive infection protein GNE05_RS20795 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GNE05_RS20810 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GNE05_RS20820 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GNE05_RS20825 ENOG4108UUM single-stranded DNA-binding protein GNE05_RS20830 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GNE05_RS20835 ENOG4105C3G gtp-binding protein GNE05_RS20840 ENOG4108J2R molybdopterin oxidoreductase GNE05_RS20845 ENOG4105VDK protein, conserved in bacteria GNE05_RS20860 ENOG4108ZDA Sporulation protein YyaC GNE05_RS20865 ENOG4105FA0 parb-like partition protein GNE05_RS20870 ENOG4107QJE Chromosome Partitioning Protein GNE05_RS20885 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GNE05_RS20890 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GNE05_RS20905 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)