locus-tag	class	description
DN399_RS00010	COG0592	DNA-directed DNA polymerase activity
DN399_RS00015	COG2501	S4 domain
DN399_RS00025	COG0187	DNA topoisomerase II activity
DN399_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DN399_RS00065	COG0517	IMP dehydrogenase activity
DN399_RS00065	COG0516	GMP reductase activity
DN399_RS00070	COG1686	Belongs to the peptidase S11 family
DN399_RS00100	COG1428	Deoxynucleoside kinase
DN399_RS00105	COG1428	Deoxynucleoside kinase
DN399_RS00110	COG1335	isochorismatase
DN399_RS00120	COG0590	tRNA wobble adenosine to inosine editing
DN399_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DN399_RS00185	COG1982	Orn Lys Arg decarboxylase major
DN399_RS00195	COG0470	DNA polymerase III
DN399_RS00200	COG1774	PSP1 C-terminal conserved region
DN399_RS00210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DN399_RS00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DN399_RS00225	COG2002	toxin-antitoxin pair type II binding
DN399_RS00235	COG0084	hydrolase, TatD family'
DN399_RS00255	COG4466	Protein conserved in bacteria
DN399_RS00270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DN399_RS00275	COG0251	oxidation-reduction process
DN399_RS00305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DN399_RS00310	COG2002	toxin-antitoxin pair type II binding
DN399_RS00315	COG2244	polysaccharide biosynthetic process
DN399_RS00320	COG3956	TIGRFAM MazG family protein
DN399_RS00325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DN399_RS00345	COG1098	S1 RNA binding domain
DN399_RS00360	COG2208	phosphoserine phosphatase activity
DN399_RS00370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DN399_RS00375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DN399_RS00390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DN399_RS00395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DN399_RS00400	COG0512	Glutamine amidotransferase of anthranilate synthase
DN399_RS00405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN399_RS00410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DN399_RS00415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DN399_RS00420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DN399_RS00425	COG1396	sequence-specific DNA binding
DN399_RS00430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DN399_RS00520	COG3880	PFAM UvrB UvrC protein
DN399_RS00530	COG0542	response to heat
DN399_RS00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DN399_RS00545	COG4956	integral membrane protein (PIN domain superfamily)
DN399_RS00565	COG1045	serine acetyltransferase
DN399_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DN399_RS00585	COG3688	RNA-binding protein containing a PIN domain
DN399_RS00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DN399_RS00605	COG0250	Participates in transcription elongation, termination and antitermination
DN399_RS00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DN399_RS00630	COG2813	Specifically methylates the guanine in position
DN399_RS00645	COG1358	cellular component organization or biogenesis
DN399_RS00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DN399_RS00720	COG0255	Belongs to the universal ribosomal protein uL29 family
DN399_RS00780	COG0201	protein transport
DN399_RS00790	COG0024	Methionine aminopeptidase
DN399_RS00800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DN399_RS00835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DN399_RS00860	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN399_RS00865	COG0489	protein tyrosine kinase activity
DN399_RS00875	COG2194	sulfuric ester hydrolase activity
DN399_RS00880	COG0726	polysaccharide deacetylase
DN399_RS00960	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DN399_RS00965	COG4856	YbbR-like protein
DN399_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS01010	COG2011	ABC-type metal ion transport system permease component
DN399_RS01015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DN399_RS01020	COG1464	Belongs to the NlpA lipoprotein family
DN399_RS01025	COG0604	alcohol dehydrogenase
DN399_RS01035	COG0277	FAD linked oxidase domain protein
DN399_RS01040	COG2271	Major facilitator Superfamily
DN399_RS01050	COG2814	Major facilitator Superfamily
DN399_RS01065	COG0601	transmembrane transport
DN399_RS01070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN399_RS01075	COG0444	Belongs to the ABC transporter superfamily
DN399_RS01080	COG4608	Belongs to the ABC transporter superfamily
DN399_RS01085	COG4166	transmembrane transport
DN399_RS01095	COG2207	Transcriptional regulator
DN399_RS01110	COG4166	transmembrane transport
DN399_RS01115	COG4166	transmembrane transport
DN399_RS01120	COG0656	L-ascorbic acid biosynthetic process
DN399_RS01135	COG4149	molybdate abc transporter
DN399_RS01140	COG0725	ABC transporter, periplasmic molybdate-binding protein
DN399_RS01145	COG1910	domain protein
DN399_RS01160	COG0697	spore germination
DN399_RS01175	COG0204	Acyl-transferase
DN399_RS01185	COG1609	Transcriptional regulator
DN399_RS01195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS01210	COG5298	Protein conserved in bacteria
DN399_RS01230	COG0488	(ABC) transporter
DN399_RS01245	COG0747	negative chemotaxis
DN399_RS01250	COG0601	transmembrane transport
DN399_RS01255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN399_RS01260	COG0444	Belongs to the ABC transporter superfamily
DN399_RS01265	COG4608	Belongs to the ABC transporter superfamily
DN399_RS01270	COG0561	phosphatase activity
DN399_RS01300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DN399_RS01305	COG0179	Fumarylacetoacetate (FAA) hydrolase
DN399_RS01315	COG0531	amino acid
DN399_RS01320	COG2814	Major facilitator Superfamily
DN399_RS01330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DN399_RS01340	COG4294	response to UV
DN399_RS01345	COG0705	Rhomboid family
DN399_RS01355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DN399_RS01360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DN399_RS01365	COG0864	Transcriptional regulator
DN399_RS01370	COG2337	Toxic component of a toxin-antitoxin (TA) module
DN399_RS01375	COG2183	response to ionizing radiation
DN399_RS01475	COG0802	atpase or kinase
DN399_RS01480	COG1214	PFAM Peptidase M22, glycoprotease
DN399_RS01485	COG0456	acetyltransferase
DN399_RS01495	COG0488	(ABC) transporter
DN399_RS01510	COG1266	CAAX protease self-immunity
DN399_RS01530	COG2252	PERMEase
DN399_RS01540	COG5002	protein histidine kinase activity
DN399_RS01565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DN399_RS01610	COG2205	protein histidine kinase activity
DN399_RS01615	COG0745	RESPONSE REGULATOR receiver
DN399_RS01645	COG2226	methyltransferase
DN399_RS01655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DN399_RS01665	COG1216	Glycosyl transferase, family 2
DN399_RS01665	COG0463	Glycosyl transferase, family 2
DN399_RS01685	COG0697	spore germination
DN399_RS01715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DN399_RS01720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DN399_RS01725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DN399_RS01735	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DN399_RS01750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DN399_RS01760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DN399_RS01770	COG0151	Belongs to the GarS family
DN399_RS01800	COG0210	DNA helicase
DN399_RS01810	COG4851	CamS sex pheromone cAM373 precursor
DN399_RS01825	COG1335	isochorismatase
DN399_RS01835	COG2011	ABC-type metal ion transport system permease component
DN399_RS01840	COG1464	Belongs to the NlpA lipoprotein family
DN399_RS01855	COG0003	Pfam Anion-transporting ATPase
DN399_RS01860	COG1846	Transcriptional regulator
DN399_RS01865	COG4682	membrane
DN399_RS01885	COG1597	lipid kinase activity
DN399_RS01895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DN399_RS01905	COG1012	belongs to the aldehyde dehydrogenase family
DN399_RS01910	COG2076	Multidrug Resistance protein
DN399_RS01920	COG2309	aminopeptidase activity
DN399_RS01935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN399_RS01945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DN399_RS01950	COG4807	Protein conserved in bacteria
DN399_RS01980	COG1757	Na H antiporter
DN399_RS01985	COG1473	amidohydrolase
DN399_RS02000	COG0450	alkyl hydroperoxide reductase
DN399_RS02020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS02025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS02030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN399_RS02040	COG0492	ferredoxin-NADP+ reductase activity
DN399_RS02055	COG0166	Belongs to the GPI family
DN399_RS02080	COG5002	protein histidine kinase activity
DN399_RS02100	COG3541	Predicted nucleotidyltransferase
DN399_RS02105	COG2814	Major facilitator Superfamily
DN399_RS02110	COG0723	plastoquinol--plastocyanin reductase activity
DN399_RS02110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN399_RS02120	COG0765	amino acid transport
DN399_RS02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN399_RS02135	COG0840	transmembrane signaling receptor activity
DN399_RS02160	COG0549	Belongs to the carbamate kinase family
DN399_RS02165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN399_RS02175	COG0277	FAD linked oxidase domain protein
DN399_RS02180	COG0366	Alpha amylase catalytic
DN399_RS02185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN399_RS02185	COG1263	PTS System
DN399_RS02185	COG2190	(PTS) system
DN399_RS02215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DN399_RS02235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN399_RS02240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN399_RS02245	COG1116	anion transmembrane transporter activity
DN399_RS02300	COG2270	Major facilitator Superfamily
DN399_RS02330	COG2310	stress, protein
DN399_RS02335	COG2310	stress, protein
DN399_RS02340	COG2310	stress, protein
DN399_RS02345	COG0861	Integral membrane protein TerC family
DN399_RS02355	COG3853	Toxic anion resistance protein (TelA)
DN399_RS02370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DN399_RS02380	COG1295	ribonuclease BN
DN399_RS02385	COG2217	Heavy metal translocating P-type atpase
DN399_RS02390	COG0697	spore germination
DN399_RS02410	COG0586	Pfam SNARE associated Golgi protein
DN399_RS02425	COG3871	stress protein (general stress protein 26)
DN399_RS02430	COG0387	Pfam Sodium calcium exchanger
DN399_RS02440	COG0535	radical SAM domain protein
DN399_RS02460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DN399_RS02465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DN399_RS02480	COG3829	transcription factor binding
DN399_RS02490	COG0833	amino acid
DN399_RS02495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN399_RS02525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN399_RS02525	COG1263	PTS System
DN399_RS02530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN399_RS02545	COG0463	Glycosyl transferase, family 2
DN399_RS02555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DN399_RS02555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DN399_RS02575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DN399_RS02595	COG1228	amidohydrolase
DN399_RS02600	COG1090	epimerase
DN399_RS02630	COG1988	membrane-bound metal-dependent
DN399_RS02635	COG1194	a g-specific adenine glycosylase
DN399_RS02660	COG1132	(ABC) transporter
DN399_RS02665	COG4129	membrane
DN399_RS02670	COG0067	glutamate synthase
DN399_RS02670	COG0070	glutamate synthase
DN399_RS02670	COG0069	glutamate synthase activity
DN399_RS02680	COG4555	ABC transporter
DN399_RS02700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DN399_RS02705	COG0735	belongs to the Fur family
DN399_RS02825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DN399_RS02850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DN399_RS02860	COG2766	serine protein kinase
DN399_RS02880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DN399_RS02890	COG1585	Membrane protein implicated in regulation of membrane protease activity
DN399_RS02895	COG2268	Band 7 protein
DN399_RS02905	COG3290	protein histidine kinase activity
DN399_RS02910	COG4565	transcriptional regulatory protein
DN399_RS02915	COG2851	Citrate transporter
DN399_RS02940	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DN399_RS02945	COG3842	ATPase activity
DN399_RS02950	COG1175	transmembrane transport
DN399_RS02955	COG0395	ABC-type sugar transport system, permease component
DN399_RS02965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DN399_RS02970	COG0745	RESPONSE REGULATOR receiver
DN399_RS02975	COG5002	protein histidine kinase activity
DN399_RS02975	COG3850	Histidine kinase
DN399_RS02985	COG4990	cell redox homeostasis
DN399_RS02995	COG3290	protein histidine kinase activity
DN399_RS03000	COG4565	transcriptional regulatory protein
DN399_RS03005	COG3493	citrate carrier protein
DN399_RS03010	COG0281	malic enzyme
DN399_RS03020	COG0697	spore germination
DN399_RS03025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN399_RS03035	COG5002	protein histidine kinase activity
DN399_RS03045	COG0454	-acetyltransferase
DN399_RS03045	COG0456	acetyltransferase
DN399_RS03050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DN399_RS03055	COG3383	formate dehydrogenase (NAD+) activity
DN399_RS03060	COG2427	Protein of unknown function (DUF1641)
DN399_RS03075	COG0531	amino acid
DN399_RS03085	COG0640	Transcriptional regulator
DN399_RS03090	COG2217	Heavy metal translocating P-type atpase
DN399_RS03095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DN399_RS03110	COG3227	Zinc metalloprotease (Elastase)
DN399_RS03130	COG2720	vancomycin resistance protein
DN399_RS03135	COG1316	TRANSCRIPTIONal
DN399_RS03140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN399_RS03145	COG0346	lactoylglutathione lyase activity
DN399_RS03150	COG1253	flavin adenine dinucleotide binding
DN399_RS03155	COG1027	Aspartate ammonia-lyase
DN399_RS03160	COG1620	l-lactate permease
DN399_RS03175	COG3104	oligopeptide transport
DN399_RS03180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN399_RS03185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS03190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS03200	COG2226	methyltransferase
DN399_RS03210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DN399_RS03220	COG4548	von Willebrand factor, type A
DN399_RS03225	COG0714	Associated with various cellular activities
DN399_RS03245	COG0531	amino acid
DN399_RS03250	COG2188	Transcriptional regulator
DN399_RS03255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN399_RS03255	COG1263	PTS System
DN399_RS03260	COG0366	Alpha amylase catalytic
DN399_RS03275	COG0697	spore germination
DN399_RS03280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DN399_RS03285	COG1115	amino acid carrier protein
DN399_RS03295	COG1126	abc transporter atp-binding protein
DN399_RS03300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN399_RS03305	COG0765	amino acid transport
DN399_RS03310	COG0765	amino acid transport
DN399_RS03315	COG0833	amino acid
DN399_RS03330	COG2378	regulation of single-species biofilm formation
DN399_RS03335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DN399_RS03340	COG5002	protein histidine kinase activity
DN399_RS03365	COG0659	secondary active sulfate transmembrane transporter activity
DN399_RS03380	COG2271	Major facilitator Superfamily
DN399_RS03385	COG1846	Transcriptional regulator
DN399_RS03390	COG0477	Major facilitator Superfamily
DN399_RS03395	COG1609	Transcriptional regulator
DN399_RS03400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN399_RS03415	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN399_RS03420	COG1879	ABC-type sugar transport system periplasmic component
DN399_RS03445	COG1063	alcohol dehydrogenase
DN399_RS03495	COG0840	transmembrane signaling receptor activity
DN399_RS03500	COG3584	3D domain protein
DN399_RS03500	COG3583	domain protein
DN399_RS03505	COG1476	TRANSCRIPTIONal
DN399_RS03525	COG3104	oligopeptide transport
DN399_RS03530	COG1114	Component of the transport system for branched-chain amino acids
DN399_RS03545	COG1113	amino acid transport
DN399_RS03550	COG2252	PERMEase
DN399_RS03565	COG2153	protein acetylation
DN399_RS03575	COG0569	domain protein
DN399_RS03575	COG0475	glutathione-regulated potassium exporter activity
DN399_RS03585	COG1845	cytochrome c oxidase, subunit III
DN399_RS03590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DN399_RS03600	COG0833	amino acid
DN399_RS03605	COG4990	cell redox homeostasis
DN399_RS03620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN399_RS03625	COG0697	spore germination
DN399_RS03630	COG0531	amino acid
DN399_RS03640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN399_RS03645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN399_RS03650	COG1918	ferrous iron import across plasma membrane
DN399_RS03650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN399_RS03655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DN399_RS03660	COG0573	inorganic phosphate transmembrane transporter activity
DN399_RS03665	COG0581	inorganic phosphate transmembrane transporter activity
DN399_RS03675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DN399_RS03795	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DN399_RS03815	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DN399_RS03820	COG1116	anion transmembrane transporter activity
DN399_RS03825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN399_RS03830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN399_RS03835	COG0352	thiamine-phosphate diphosphorylase activity
DN399_RS03840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN399_RS03845	COG2104	thiamine diphosphate biosynthetic process
DN399_RS03855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DN399_RS03860	COG0351	phosphomethylpyrimidine kinase
DN399_RS03900	COG2205	protein histidine kinase activity
DN399_RS03905	COG2814	Major facilitator Superfamily
DN399_RS03910	COG1846	Transcriptional regulator
DN399_RS03920	COG2252	PERMEase
DN399_RS03925	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS03940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DN399_RS03945	COG1621	beta-fructofuranosidase activity
DN399_RS03950	COG1263	PTS System
DN399_RS03950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN399_RS03955	COG1609	Transcriptional regulator
DN399_RS04005	COG0778	Nitroreductase
DN399_RS04010	COG2719	SpoVR family
DN399_RS04020	COG3591	Belongs to the peptidase S1B family
DN399_RS04045	COG0446	pyridine nucleotide-disulphide oxidoreductase
DN399_RS04050	COG1937	Protein conserved in bacteria
DN399_RS04055	COG0425	Belongs to the sulfur carrier protein TusA family
DN399_RS04055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN399_RS04060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN399_RS04060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS04065	COG0425	Belongs to the sulfur carrier protein TusA family
DN399_RS04070	COG0425	Belongs to the sulfur carrier protein TusA family
DN399_RS04070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN399_RS04075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN399_RS04080	COG2210	Belongs to the sulfur carrier protein TusA family
DN399_RS04085	COG0730	response to heat
DN399_RS04095	COG1316	TRANSCRIPTIONal
DN399_RS04100	COG0604	alcohol dehydrogenase
DN399_RS04105	COG1283	sodium-dependent phosphate transmembrane transporter activity
DN399_RS04125	COG3711	transcriptional antiterminator
DN399_RS04125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN399_RS04130	COG1447	Phosphotransferase system cellobiose-specific component IIA
DN399_RS04135	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DN399_RS04160	COG1388	LysM domain
DN399_RS04160	COG3584	3D domain protein
DN399_RS04165	COG0577	efflux transmembrane transporter activity
DN399_RS04170	COG1136	(ABC) transporter
DN399_RS04180	COG5522	Integral membrane protein (intg_mem_TP0381)
DN399_RS04195	COG1114	Component of the transport system for branched-chain amino acids
DN399_RS04200	COG3546	catalase activity
DN399_RS04235	COG0586	Pfam SNARE associated Golgi protein
DN399_RS04265	COG0531	amino acid
DN399_RS04270	COG0475	glutathione-regulated potassium exporter activity
DN399_RS04280	COG1737	Transcriptional regulator
DN399_RS04290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN399_RS04290	COG1263	PTS System
DN399_RS04300	COG2259	Doxx family
DN399_RS04320	COG1522	sequence-specific DNA binding
DN399_RS04325	COG0165	Argininosuccinate lyase
DN399_RS04325	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DN399_RS04330	COG0300	oxidoreductase activity
DN399_RS04355	COG1309	transcriptional regulator
DN399_RS04360	COG2814	Major facilitator Superfamily
DN399_RS04365	COG1733	regulation of RNA biosynthetic process
DN399_RS04380	COG4533	DNA binding
DN399_RS04385	COG2211	Major facilitator Superfamily
DN399_RS04395	COG0693	protein deglycase activity
DN399_RS04410	COG0531	amino acid
DN399_RS04425	COG1012	belongs to the aldehyde dehydrogenase family
DN399_RS04440	COG1132	(ABC) transporter
DN399_RS04445	COG1132	(ABC) transporter
DN399_RS04455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN399_RS04460	COG0765	amino acid transport
DN399_RS04465	COG1126	abc transporter atp-binding protein
DN399_RS04480	COG0189	ligase activity
DN399_RS04510	COG0028	Belongs to the TPP enzyme family
DN399_RS04515	COG3527	Alpha-acetolactate decarboxylase
DN399_RS04530	COG0561	phosphatase activity
DN399_RS04540	COG5632	N-Acetylmuramoyl-L-alanine amidase
DN399_RS04540	COG3409	Peptidoglycan-binding domain 1 protein
DN399_RS04545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DN399_RS04550	COG0318	PFAM AMP-dependent synthetase and ligase
DN399_RS04565	COG0659	secondary active sulfate transmembrane transporter activity
DN399_RS04570	COG2244	polysaccharide biosynthetic process
DN399_RS04595	COG1024	Enoyl-CoA hydratase
DN399_RS04615	COG1363	Peptidase, m42
DN399_RS04650	COG0601	transmembrane transport
DN399_RS04655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN399_RS04660	COG0444	Belongs to the ABC transporter superfamily
DN399_RS04665	COG4608	Belongs to the ABC transporter superfamily
DN399_RS04675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS04695	COG0477	Major facilitator Superfamily
DN399_RS04700	COG3290	protein histidine kinase activity
DN399_RS04705	COG4565	transcriptional regulatory protein
DN399_RS04710	COG3181	Tripartite tricarboxylate transporter family receptor
DN399_RS04745	COG0789	Transcriptional regulator
DN399_RS04745	COG4978	Transcriptional regulator
DN399_RS04760	COG0305	Participates in initiation and elongation during chromosome replication
DN399_RS04785	COG0477	Major facilitator Superfamily
DN399_RS04800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS04825	COG1073	alpha beta
DN399_RS04865	COG1183	phosphatidylcholine synthase activity
DN399_RS04885	COG2376	Dihydroxyacetone kinase
DN399_RS04900	COG2376	Dihydroxyacetone kinase
DN399_RS04940	COG2373	Large extracellular alpha-helical protein
DN399_RS04960	COG0596	Alpha beta hydrolase
DN399_RS05030	COG1191	sigma factor activity
DN399_RS05040	COG2208	phosphoserine phosphatase activity
DN399_RS05045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DN399_RS05050	COG5002	protein histidine kinase activity
DN399_RS05050	COG0784	Response regulator, receiver
DN399_RS05050	COG2205	protein histidine kinase activity
DN399_RS05090	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DN399_RS05110	COG0420	3'-5' exonuclease activity
DN399_RS05115	COG4717	serine-type aminopeptidase activity
DN399_RS05125	COG0346	lactoylglutathione lyase activity
DN399_RS05130	COG0346	lactoylglutathione lyase activity
DN399_RS05135	COG0457	Tetratricopeptide repeat
DN399_RS05150	COG2267	carboxylic ester hydrolase activity
DN399_RS05165	COG2140	Oxalate decarboxylase
DN399_RS05170	COG3620	sequence-specific DNA binding
DN399_RS05175	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DN399_RS05180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DN399_RS05190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DN399_RS05195	COG1695	Transcriptional regulator
DN399_RS05225	COG1033	growth of symbiont in host cell
DN399_RS05225	COG2409	Drug exporters of the RND superfamily
DN399_RS05230	COG3973	AAA domain
DN399_RS05265	COG4980	gas vesicle protein
DN399_RS05270	COG0537	adenosine 5'-monophosphoramidase activity
DN399_RS05275	COG1131	(ABC) transporter
DN399_RS05280	COG4473	ABC transporter
DN399_RS05300	COG3402	PFAM membrane-flanked domain
DN399_RS05305	COG3428	Bacterial PH domain
DN399_RS05345	COG0697	spore germination
DN399_RS05350	COG3402	PFAM membrane-flanked domain
DN399_RS05355	COG3428	Bacterial PH domain
DN399_RS05360	COG2329	Antibiotic biosynthesis monooxygenase
DN399_RS05365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN399_RS05380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DN399_RS05405	COG1309	transcriptional regulator
DN399_RS05410	COG1511	domain protein
DN399_RS05440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS05445	COG1609	Transcriptional regulator
DN399_RS05455	COG1234	tRNA 3'-trailer cleavage
DN399_RS05460	COG0095	Lipoate-protein ligase
DN399_RS05470	COG0318	PFAM AMP-dependent synthetase and ligase
DN399_RS05480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DN399_RS05490	COG4208	sulfate ABC transporter
DN399_RS05570	COG1408	metallophosphoesterase
DN399_RS05575	COG1078	dGTPase activity
DN399_RS05585	COG1595	DNA-templated transcription, initiation
DN399_RS05590	COG2207	Transcriptional regulator
DN399_RS05590	COG3708	Transcriptional regulator
DN399_RS05595	COG2205	protein histidine kinase activity
DN399_RS05600	COG0745	RESPONSE REGULATOR receiver
DN399_RS05620	COG0501	Belongs to the peptidase M48B family
DN399_RS05625	COG0840	transmembrane signaling receptor activity
DN399_RS05630	COG3693	PFAM glycoside hydrolase, family 10
DN399_RS05640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DN399_RS05645	COG2224	Isocitrate lyase
DN399_RS05660	COG1278	Cold shock
DN399_RS05680	COG0398	Pfam SNARE associated Golgi protein
DN399_RS05740	COG0179	Fumarylacetoacetate (FAA) hydrolase
DN399_RS05765	COG0367	asparagine synthase
DN399_RS05775	COG0753	catalase activity
DN399_RS05780	COG0004	ammonium transporteR
DN399_RS05805	COG2996	Protein conserved in bacteria
DN399_RS05820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS05835	COG0561	phosphatase activity
DN399_RS05855	COG2267	carboxylic ester hydrolase activity
DN399_RS05875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DN399_RS05880	COG5504	Zn-dependent protease
DN399_RS05895	COG0180	Tryptophanyl-tRNA synthetase
DN399_RS05910	COG4166	transmembrane transport
DN399_RS05915	COG0601	transmembrane transport
DN399_RS05920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN399_RS05925	COG0444	Belongs to the ABC transporter superfamily
DN399_RS05930	COG4608	Belongs to the ABC transporter superfamily
DN399_RS05935	COG0534	Mate efflux family protein
DN399_RS05940	COG4166	transmembrane transport
DN399_RS05955	COG0861	Integral membrane protein TerC family
DN399_RS05975	COG1164	Oligoendopeptidase f
DN399_RS05985	COG2346	COG2346, Truncated hemoglobins
DN399_RS05990	COG4116	CYTH
DN399_RS06000	COG2357	RelA SpoT domain protein
DN399_RS06010	COG0564	pseudouridine synthase activity
DN399_RS06025	COG0772	Belongs to the SEDS family
DN399_RS06030	COG1216	Glycosyl transferase, family 2
DN399_RS06050	COG0463	Glycosyl transferase, family 2
DN399_RS06050	COG0457	Tetratricopeptide repeat
DN399_RS06070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DN399_RS06085	COG1091	dTDP-4-dehydrorhamnose reductase activity
DN399_RS06130	COG2153	protein acetylation
DN399_RS06140	COG2382	esterase
DN399_RS06165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN399_RS06175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DN399_RS06175	COG0512	Glutamine amidotransferase of anthranilate synthase
DN399_RS06210	COG1620	l-lactate permease
DN399_RS06215	COG5634	Uncharacterized conserved protein (DUF2278)
DN399_RS06265	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN399_RS06275	COG1476	TRANSCRIPTIONal
DN399_RS06330	COG1686	Belongs to the peptidase S11 family
DN399_RS06335	COG0681	Belongs to the peptidase S26 family
DN399_RS06370	COG1012	belongs to the aldehyde dehydrogenase family
DN399_RS06380	COG1176	ABC-type spermidine putrescine transport system, permease component I
DN399_RS06385	COG1177	transmembrane transport
DN399_RS06400	COG2409	Drug exporters of the RND superfamily
DN399_RS06410	COG0564	pseudouridine synthase activity
DN399_RS06420	COG2340	Cysteine-rich secretory protein family
DN399_RS06425	COG0247	lactate metabolic process
DN399_RS06430	COG0277	FAD linked oxidase domain protein
DN399_RS06435	COG3835	regulator
DN399_RS06445	COG0745	RESPONSE REGULATOR receiver
DN399_RS06450	COG5002	protein histidine kinase activity
DN399_RS06455	COG2186	Transcriptional regulator
DN399_RS06475	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DN399_RS06485	COG2116	formate transmembrane transporter activity
DN399_RS06490	COG0861	Integral membrane protein TerC family
DN399_RS06495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DN399_RS06505	COG2030	dehydratase
DN399_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS06530	COG3243	poly(R)-hydroxyalkanoic acid synthase
DN399_RS06540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DN399_RS06555	COG1840	ABC-type Fe3 transport system, periplasmic component
DN399_RS06560	COG3842	ATPase activity
DN399_RS06585	COG1349	DNA-binding transcription factor activity
DN399_RS06595	COG0235	Class ii aldolase
DN399_RS06605	COG2861	carbohydrate metabolic process
DN399_RS06615	COG3852	Histidine kinase
DN399_RS06620	COG1846	Transcriptional regulator
DN399_RS06630	COG2318	DinB family
DN399_RS06635	COG5002	protein histidine kinase activity
DN399_RS06645	COG0720	synthase
DN399_RS06660	COG4873	Protein conserved in bacteria
DN399_RS06690	COG1780	Probably involved in ribonucleotide reductase function
DN399_RS06695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DN399_RS06700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DN399_RS06705	COG1725	Transcriptional regulator
DN399_RS06710	COG1131	(ABC) transporter
DN399_RS06720	COG1131	(ABC) transporter
DN399_RS06725	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DN399_RS06740	COG1522	sequence-specific DNA binding
DN399_RS06750	COG1335	isochorismatase
DN399_RS06760	COG1619	proteins homologs of microcin C7 resistance protein MccF
DN399_RS06765	COG2070	2-Nitropropane dioxygenase
DN399_RS06770	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DN399_RS06780	COG1696	Membrane protein involved in D-alanine export
DN399_RS06800	COG0716	FMN binding
DN399_RS06845	COG1846	Transcriptional regulator
DN399_RS06855	COG1301	dicarboxylic acid transport
DN399_RS06860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DN399_RS06865	COG4709	membrane
DN399_RS06870	COG3874	Sporulation protein YtfJ
DN399_RS06890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN399_RS06895	COG0028	Belongs to the TPP enzyme family
DN399_RS06900	COG0440	acetolactate synthase activity
DN399_RS06975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DN399_RS06990	COG1183	phosphatidylcholine synthase activity
DN399_RS06995	COG1368	sulfuric ester hydrolase activity
DN399_RS07005	COG0019	diaminopimelate decarboxylase activity
DN399_RS07025	COG0529	Catalyzes the synthesis of activated sulfate
DN399_RS07030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DN399_RS07050	COG1648	precorrin-2 dehydrogenase activity
DN399_RS07055	COG0733	neurotransmitter:sodium symporter activity
DN399_RS07075	COG1757	Na H antiporter
DN399_RS07090	COG4758	membrane
DN399_RS07095	COG4585	Histidine kinase
DN399_RS07100	COG2197	response regulator
DN399_RS07110	COG1114	Component of the transport system for branched-chain amino acids
DN399_RS07160	COG0730	response to heat
DN399_RS07165	COG0306	phosphate transporter
DN399_RS07170	COG1392	Phosphate transport regulator
DN399_RS07175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN399_RS07190	COG3852	Histidine kinase
DN399_RS07195	COG1801	Protein of unknown function DUF72
DN399_RS07205	COG0582	viral genome integration into host DNA
DN399_RS07210	COG5002	protein histidine kinase activity
DN399_RS07230	COG0392	lysyltransferase activity
DN399_RS07230	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DN399_RS07245	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DN399_RS07250	COG1686	Belongs to the peptidase S11 family
DN399_RS07255	COG2715	membrane protein required for spore maturation
DN399_RS07260	COG0700	Nucleoside recognition
DN399_RS07265	COG1187	pseudouridine synthase activity
DN399_RS07275	COG1333	cytochrome c biogenesis protein
DN399_RS07280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DN399_RS07285	COG0745	RESPONSE REGULATOR receiver
DN399_RS07290	COG5002	protein histidine kinase activity
DN399_RS07295	COG2096	Adenosyltransferase
DN399_RS07310	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DN399_RS07315	COG1141	Ferredoxin
DN399_RS07325	COG0514	ATP-dependent DNA helicase (RecQ)
DN399_RS07330	COG1266	CAAX protease self-immunity
DN399_RS07340	COG1408	metallophosphoesterase
DN399_RS07345	COG0789	Transcriptional regulator
DN399_RS07355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DN399_RS07375	COG0492	ferredoxin-NADP+ reductase activity
DN399_RS07380	COG0252	asparaginase activity
DN399_RS07445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DN399_RS07460	COG0142	geranyltranstransferase activity
DN399_RS07470	COG0142	geranyltranstransferase activity
DN399_RS07495	COG0457	Tetratricopeptide repeat
DN399_RS07515	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DN399_RS07520	COG2010	Cytochrome c
DN399_RS07520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DN399_RS07525	COG4347	Protein of unknown function (DUF1405)
DN399_RS07540	COG2738	Putative neutral zinc metallopeptidase
DN399_RS07550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS07560	COG1694	Mazg nucleotide pyrophosphohydrolase
DN399_RS07580	COG0438	transferase activity, transferring glycosyl groups
DN399_RS07615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DN399_RS07615	COG1199	ATP-dependent helicase activity
DN399_RS07635	COG3935	DnaD domain protein
DN399_RS07640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DN399_RS07650	COG4499	WXG100 protein secretion system (Wss), protein YukC
DN399_RS07650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN399_RS07705	COG0116	Belongs to the methyltransferase superfamily
DN399_RS07715	COG1199	ATP-dependent helicase activity
DN399_RS07720	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DN399_RS07730	COG0024	Methionine aminopeptidase
DN399_RS07745	COG2233	PERMEase
DN399_RS07750	COG2311	Membrane
DN399_RS07755	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DN399_RS07765	COG0456	acetyltransferase
DN399_RS07800	COG0754	glutathionylspermidine amidase activity
DN399_RS07820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN399_RS07835	COG3944	biosynthesis protein
DN399_RS07845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DN399_RS07860	COG1215	transferase activity, transferring glycosyl groups
DN399_RS07865	COG0438	transferase activity, transferring glycosyl groups
DN399_RS07880	COG0454	-acetyltransferase
DN399_RS07900	COG0328	RNA-DNA hybrid ribonuclease activity
DN399_RS07935	COG3403	YqcI/YcgG family
DN399_RS07940	COG1280	lysine exporter protein (LysE YggA)
DN399_RS07960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN399_RS07965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN399_RS07975	COG0475	glutathione-regulated potassium exporter activity
DN399_RS07980	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DN399_RS07985	COG0789	Transcriptional regulator
DN399_RS07985	COG4978	Transcriptional regulator
DN399_RS07995	COG2323	membrane
DN399_RS08000	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DN399_RS08035	COG1923	regulation of RNA biosynthetic process
DN399_RS08045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DN399_RS08050	COG1360	Flagellar Motor Protein
DN399_RS08055	COG2201	protein-glutamate methylesterase activity
DN399_RS08060	COG2198	Histidine kinase
DN399_RS08060	COG0643	Histidine kinase
DN399_RS08065	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DN399_RS08065	COG1776	CheC inhibitor of MCP methylation
DN399_RS08080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DN399_RS08100	COG1256	bacterial-type flagellum assembly
DN399_RS08105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DN399_RS08125	COG1815	bacterial-type flagellum-dependent cell motility
DN399_RS08130	COG1558	bacterial-type flagellum-dependent cell motility
DN399_RS08140	COG1766	The M ring may be actively involved in energy transduction
DN399_RS08145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DN399_RS08155	COG1157	protein secretion by the type III secretion system
DN399_RS08175	COG1749	Flagellar hook protein flgE
DN399_RS08190	COG0835	chemotaxis
DN399_RS08190	COG0784	Response regulator, receiver
DN399_RS08200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DN399_RS08205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DN399_RS08210	COG0741	lytic transglycosylase activity
DN399_RS08220	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DN399_RS08225	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DN399_RS08225	COG1776	CheC inhibitor of MCP methylation
DN399_RS08235	COG1338	Plays a role in the flagellum-specific transport system
DN399_RS08240	COG1987	bacterial-type flagellum assembly
DN399_RS08250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DN399_RS08255	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DN399_RS08260	COG1419	protein localization to endoplasmic reticulum
DN399_RS08265	COG4786	Flagellar basal body rod
DN399_RS08270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DN399_RS08305	COG2329	Antibiotic biosynthesis monooxygenase
DN399_RS08330	COG0583	DNA-binding transcription factor activity
DN399_RS08350	COG1234	tRNA 3'-trailer cleavage
DN399_RS08380	COG0406	alpha-ribazole phosphatase activity
DN399_RS08410	COG0367	asparagine synthase
DN399_RS08440	COG1802	Transcriptional regulator
DN399_RS08445	COG0697	spore germination
DN399_RS08455	COG0523	cobalamin synthesis protein
DN399_RS08465	COG0701	Predicted permease
DN399_RS08480	COG1757	Na H antiporter
DN399_RS08485	COG0789	Transcriptional regulator
DN399_RS08510	COG0534	Mate efflux family protein
DN399_RS08515	COG3340	Belongs to the peptidase S51 family
DN399_RS08535	COG0785	Cytochrome C biogenesis protein
DN399_RS08540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN399_RS08560	COG2733	membrane
DN399_RS08590	COG2197	response regulator
DN399_RS08600	COG1131	(ABC) transporter
DN399_RS08620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DN399_RS08625	COG0528	UMP kinase activity
DN399_RS08635	COG1027	Aspartate ammonia-lyase
DN399_RS08640	COG0281	malic enzyme
DN399_RS08645	COG4191	Histidine kinase
DN399_RS08650	COG0784	Response regulator, receiver
DN399_RS08655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN399_RS08705	COG2814	Major facilitator Superfamily
DN399_RS08720	COG1695	Transcriptional regulator
DN399_RS08735	COG0477	Major facilitator Superfamily
DN399_RS08745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DN399_RS08750	COG2223	nitrite transmembrane transporter activity
DN399_RS08755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DN399_RS08775	COG0733	neurotransmitter:sodium symporter activity
DN399_RS08785	COG5566	PFAM Mor transcription activator
DN399_RS08790	COG2323	membrane
DN399_RS08805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN399_RS08815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN399_RS08820	COG0028	Belongs to the TPP enzyme family
DN399_RS08840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DN399_RS08865	COG2814	Major facilitator Superfamily
DN399_RS08870	COG3384	dioxygenase
DN399_RS08880	COG3279	Response regulator of the LytR AlgR family
DN399_RS08885	COG0427	acetyl-CoA hydrolase
DN399_RS08905	COG4166	transmembrane transport
DN399_RS08910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS08930	COG1914	H( )-stimulated, divalent metal cation uptake system
DN399_RS08945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DN399_RS08950	COG0531	amino acid
DN399_RS08980	COG2309	aminopeptidase activity
DN399_RS08995	COG0456	acetyltransferase
DN399_RS09015	COG1309	transcriptional regulator
DN399_RS09020	COG2390	Transcriptional regulator
DN399_RS09030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN399_RS09035	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DN399_RS09070	COG4846	Membrane protein involved in cytochrome C biogenesis
DN399_RS09090	COG0583	DNA-binding transcription factor activity
DN399_RS09105	COG0006	proline dipeptidase activity
DN399_RS09115	COG2132	Multicopper oxidase
DN399_RS09140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN399_RS09160	COG1114	Component of the transport system for branched-chain amino acids
DN399_RS09170	COG2372	response to copper ion
DN399_RS09170	COG1276	copper resistance
DN399_RS09175	COG4549	nuclear export factor GLE1
DN399_RS09180	COG0697	spore germination
DN399_RS09185	COG0583	DNA-binding transcription factor activity
DN399_RS09190	COG1959	2 iron, 2 sulfur cluster binding
DN399_RS09195	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DN399_RS09200	COG0778	Nitroreductase
DN399_RS09210	COG0628	permease
DN399_RS09220	COG1231	oxidoreductase activity
DN399_RS09230	COG0523	cobalamin synthesis protein
DN399_RS09240	COG0411	ABC transporter
DN399_RS09260	COG0583	DNA-binding transcription factor activity
DN399_RS09270	COG1942	4-Oxalocrotonate Tautomerase
DN399_RS09285	COG1271	oxidase subunit
DN399_RS09290	COG1294	oxidase, subunit
DN399_RS09295	COG4988	ABC transporter
DN399_RS09300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DN399_RS09310	COG1216	Glycosyl transferase, family 2
DN399_RS09350	COG1686	Belongs to the peptidase S11 family
DN399_RS09365	COG1388	LysM domain
DN399_RS09365	COG0791	NLP P60 protein
DN399_RS09375	COG1132	(ABC) transporter
DN399_RS09380	COG0745	RESPONSE REGULATOR receiver
DN399_RS09385	COG5002	protein histidine kinase activity
DN399_RS09390	COG0300	oxidoreductase activity
DN399_RS09420	COG0460	homoserine dehydrogenase
DN399_RS09445	COG1316	TRANSCRIPTIONal
DN399_RS09455	COG0745	RESPONSE REGULATOR receiver
DN399_RS09460	COG5002	protein histidine kinase activity
DN399_RS09475	COG1285	pathogenesis
DN399_RS09480	COG1247	-acetyltransferase
DN399_RS09500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN399_RS09510	COG1082	Xylose isomerase domain protein TIM barrel
DN399_RS09520	COG2814	Major facilitator Superfamily
DN399_RS09525	COG1279	arginine transmembrane transporter activity
DN399_RS09530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN399_RS09540	COG1752	Esterase of the alpha-beta hydrolase superfamily
DN399_RS09575	COG0577	efflux transmembrane transporter activity
DN399_RS09580	COG2002	toxin-antitoxin pair type II binding
DN399_RS09585	COG1404	Belongs to the peptidase S8 family
DN399_RS09600	COG3152	Membrane
DN399_RS09625	COG0840	transmembrane signaling receptor activity
DN399_RS09640	COG3949	Membrane
DN399_RS09645	COG0783	Belongs to the Dps family
DN399_RS09660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN399_RS09670	COG1231	oxidoreductase activity
DN399_RS09675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS09680	COG4989	oxidoreductase activity
DN399_RS09690	COG0523	cobalamin synthesis protein
DN399_RS09695	COG0456	acetyltransferase
DN399_RS09700	COG0803	Belongs to the bacterial solute-binding protein 9 family
DN399_RS09705	COG0702	epimerase
DN399_RS09715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DN399_RS09725	COG4166	transmembrane transport
DN399_RS09750	COG5337	Spore coat protein CotH
DN399_RS09755	COG1051	belongs to the nudix hydrolase family
DN399_RS09760	COG0586	Pfam SNARE associated Golgi protein
DN399_RS09765	COG2244	polysaccharide biosynthetic process
DN399_RS09775	COG0701	Predicted permease
DN399_RS09780	COG3689	TIGRFAM TIGR03943 family protein
DN399_RS09785	COG1607	acyl-coa hydrolase
DN399_RS09795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DN399_RS09810	COG0702	epimerase
DN399_RS09815	COG2839	Protein conserved in bacteria
DN399_RS09820	COG1253	flavin adenine dinucleotide binding
DN399_RS09835	COG1114	Component of the transport system for branched-chain amino acids
DN399_RS09840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN399_RS09860	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN399_RS09870	COG1876	peptidase activity
DN399_RS09880	COG0154	amidase activity
DN399_RS09885	COG2211	Major facilitator Superfamily
DN399_RS09900	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN399_RS09910	COG0561	phosphatase activity
DN399_RS09925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DN399_RS09945	COG1819	glycosyl
DN399_RS09950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS09955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN399_RS09985	COG0456	acetyltransferase
DN399_RS10020	COG4499	WXG100 protein secretion system (Wss), protein YukC
DN399_RS10075	COG3874	Sporulation protein YtfJ
DN399_RS10100	COG2226	methyltransferase
DN399_RS10120	COG1082	Xylose isomerase domain protein TIM barrel
DN399_RS10125	COG0346	lactoylglutathione lyase activity
DN399_RS10135	COG0604	alcohol dehydrogenase
DN399_RS10140	COG1595	DNA-templated transcription, initiation
DN399_RS10165	COG0386	Belongs to the glutathione peroxidase family
DN399_RS10170	COG1305	Transglutaminase-like
DN399_RS10175	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DN399_RS10180	COG0714	Associated with various cellular activities
DN399_RS10185	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DN399_RS10190	COG1140	nitrate reductase beta subunit
DN399_RS10195	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DN399_RS10200	COG2181	nitrate reductase activity
DN399_RS10205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN399_RS10210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DN399_RS10215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DN399_RS10220	COG0303	'Molybdopterin
DN399_RS10225	COG0314	molybdopterin synthase activity
DN399_RS10235	COG2223	nitrite transmembrane transporter activity
DN399_RS10260	COG1648	precorrin-2 dehydrogenase activity
DN399_RS10270	COG1587	Uroporphyrinogen-III synthase
DN399_RS10270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DN399_RS10275	COG2146	nitrite reductase [NAD(P)H] activity
DN399_RS10280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DN399_RS10285	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DN399_RS10320	COG2359	stage V sporulation protein S
DN399_RS10345	COG0457	Tetratricopeptide repeat
DN399_RS10360	COG1418	mRNA catabolic process
DN399_RS10365	COG0488	(ABC) transporter
DN399_RS10380	COG0629	single-stranded DNA binding
DN399_RS10390	COG1413	lyase activity
DN399_RS10405	COG2136	Putative SAM-dependent methyltransferase
DN399_RS10405	COG2521	methyltransferase
DN399_RS10410	COG0018	arginyl-trna synthetase
DN399_RS10460	COG0017	Asparaginyl-tRNA synthetase
DN399_RS10465	COG0733	neurotransmitter:sodium symporter activity
DN399_RS10490	COG2610	gluconate transmembrane transporter activity
DN399_RS10500	COG1794	racemase activity, acting on amino acids and derivatives
DN399_RS10510	COG0456	acetyltransferase
DN399_RS10520	COG3655	Transcriptional regulator
DN399_RS10525	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DN399_RS10535	COG1131	(ABC) transporter
DN399_RS10540	COG4473	ABC transporter
DN399_RS10550	COG0546	phosphoglycolate phosphatase activity
DN399_RS10565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN399_RS10580	COG0768	penicillin binding
DN399_RS10590	COG0204	Acyl-transferase
DN399_RS10595	COG1272	protein, Hemolysin III
DN399_RS10605	COG0805	protein transport
DN399_RS10615	COG1307	EDD domain protein, DegV family
DN399_RS10625	COG1999	signal sequence binding
DN399_RS10630	COG0071	Belongs to the small heat shock protein (HSP20) family
DN399_RS10635	COG0367	asparagine synthase
DN399_RS10650	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN399_RS10655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN399_RS10660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN399_RS10680	COG1335	isochorismatase
DN399_RS10695	COG0668	transmembrane transport
DN399_RS10700	COG2203	Gaf domain
DN399_RS10700	COG4585	Histidine kinase
DN399_RS10705	COG2197	response regulator
DN399_RS10710	COG1737	Transcriptional regulator
DN399_RS10715	COG0384	phenazine biosynthesis protein PhzF
DN399_RS10720	COG1064	alcohol dehydrogenase
DN399_RS10735	COG1070	Carbohydrate kinase
DN399_RS10745	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DN399_RS10780	COG1125	glycine betaine transport
DN399_RS10780	COG0517	IMP dehydrogenase activity
DN399_RS10785	COG1174	glycine betaine transport
DN399_RS10820	COG1253	flavin adenine dinucleotide binding
DN399_RS10825	COG1012	belongs to the aldehyde dehydrogenase family
DN399_RS10830	COG5506	Protein of unknown function (DUF1694)
DN399_RS10845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN399_RS10850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DN399_RS10855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DN399_RS10860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN399_RS10865	COG0456	acetyltransferase
DN399_RS10870	COG3829	transcription factor binding
DN399_RS10875	COG1509	lysine 2,3-aminomutase activity
DN399_RS10910	COG3064	Membrane
DN399_RS10910	COG4991	sh3 domain protein
DN399_RS10910	COG0515	serine threonine protein kinase
DN399_RS10920	COG0671	phosphoesterase, PA-phosphatase related
DN399_RS10925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DN399_RS10930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN399_RS11010	COG0300	oxidoreductase activity
DN399_RS11030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN399_RS11030	COG4499	WXG100 protein secretion system (Wss), protein YukC
DN399_RS11040	COG2814	Major facilitator Superfamily
DN399_RS11045	COG4841	protein insertion into membrane
DN399_RS11050	COG0372	Belongs to the citrate synthase family
DN399_RS11055	COG2079	MmgE PrpD family protein
DN399_RS11060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DN399_RS11065	COG1960	acyl-CoA dehydrogenase activity
DN399_RS11070	COG2084	Dehydrogenase
DN399_RS11080	COG1280	lysine exporter protein (LysE YggA)
DN399_RS11085	COG1024	Enoyl-CoA hydratase
DN399_RS11100	COG0420	3'-5' exonuclease activity
DN399_RS11105	COG0419	ATPase involved in DNA repair
DN399_RS11130	COG2223	nitrite transmembrane transporter activity
DN399_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS11140	COG1169	isochorismate synthase
DN399_RS11145	COG1021	2,3-dihydroxybenzoate-AMP ligase
DN399_RS11150	COG1535	isochorismatase
DN399_RS11150	COG3433	isochorismatase activity
DN399_RS11155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN399_RS11160	COG3251	PFAM MbtH domain protein
DN399_RS11165	COG2814	Major facilitator Superfamily
DN399_RS11180	COG0776	regulation of translation
DN399_RS11190	COG2318	DinB family
DN399_RS11200	COG1115	amino acid carrier protein
DN399_RS11220	COG1187	pseudouridine synthase activity
DN399_RS11225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN399_RS11230	COG1136	(ABC) transporter
DN399_RS11240	COG2814	Major facilitator Superfamily
DN399_RS11255	COG0028	Belongs to the TPP enzyme family
DN399_RS11295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN399_RS11315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS11345	COG1247	-acetyltransferase
DN399_RS11365	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DN399_RS11375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS11400	COG0561	phosphatase activity
DN399_RS11410	COG0583	DNA-binding transcription factor activity
DN399_RS11415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DN399_RS11435	COG0583	DNA-binding transcription factor activity
DN399_RS11440	COG2258	MOSC domain
DN399_RS11455	COG1132	(ABC) transporter
DN399_RS11460	COG1132	(ABC) transporter
DN399_RS11485	COG1396	sequence-specific DNA binding
DN399_RS11520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DN399_RS11525	COG1595	DNA-templated transcription, initiation
DN399_RS11545	COG1649	PFAM Uncharacterised BCR, COG1649
DN399_RS11570	COG2971	BadF BadG BcrA BcrD
DN399_RS11590	COG1846	Transcriptional regulator
DN399_RS11605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS11680	COG0582	viral genome integration into host DNA
DN399_RS11705	COG4824	toxin secretion phage lysis holin
DN399_RS11710	COG5632	N-Acetylmuramoyl-L-alanine amidase
DN399_RS11710	COG3409	Peptidoglycan-binding domain 1 protein
DN399_RS11710	COG1388	LysM domain
DN399_RS11725	COG3615	Tellurite resistance protein tehB
DN399_RS11725	COG0500	methyltransferase
DN399_RS11740	COG3961	Belongs to the TPP enzyme family
DN399_RS11745	COG1846	Transcriptional regulator
DN399_RS11775	COG2195	Cleaves the N-terminal amino acid of tripeptides
DN399_RS11800	COG2002	toxin-antitoxin pair type II binding
DN399_RS11810	COG0730	response to heat
DN399_RS11815	COG0110	maltose O-acetyltransferase activity
DN399_RS11830	COG2814	Major facilitator Superfamily
DN399_RS11880	COG2312	Erythromycin esterase
DN399_RS11890	COG0741	lytic transglycosylase activity
DN399_RS11895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS11960	COG1760	l-serine dehydratase
DN399_RS11965	COG1760	l-serine dehydratase
DN399_RS11970	COG0814	amino acid
DN399_RS11980	COG0840	transmembrane signaling receptor activity
DN399_RS12015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN399_RS12020	COG0768	penicillin binding
DN399_RS12025	COG1595	DNA-templated transcription, initiation
DN399_RS12035	COG0768	penicillin binding
DN399_RS12040	COG0768	penicillin binding
DN399_RS12050	COG1408	metallophosphoesterase
DN399_RS12060	COG1131	(ABC) transporter
DN399_RS12070	COG1309	transcriptional regulator
DN399_RS12085	COG1960	acyl-CoA dehydrogenase activity
DN399_RS12090	COG0439	Biotin carboxylase
DN399_RS12095	COG0511	ligase activity, forming carbon-carbon bonds
DN399_RS12100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DN399_RS12105	COG1024	Enoyl-CoA hydratase
DN399_RS12110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DN399_RS12115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DN399_RS12145	COG0572	uridine kinase
DN399_RS12170	COG1686	Belongs to the peptidase S11 family
DN399_RS12195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DN399_RS12210	COG3227	Zinc metalloprotease (Elastase)
DN399_RS12215	COG2207	Transcriptional regulator
DN399_RS12245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DN399_RS12255	COG2814	Major facilitator Superfamily
DN399_RS12260	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS12270	COG1733	regulation of RNA biosynthetic process
DN399_RS12275	COG2226	methyltransferase
DN399_RS12315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN399_RS12325	COG2368	4-hydroxyphenylacetate
DN399_RS12340	COG1063	alcohol dehydrogenase
DN399_RS12350	COG2323	membrane
DN399_RS12365	COG3386	PFAM SMP-30 Gluconolaconase
DN399_RS12380	COG3773	Cell wall hydrolase
DN399_RS12390	COG0745	RESPONSE REGULATOR receiver
DN399_RS12395	COG2205	protein histidine kinase activity
DN399_RS12405	COG0488	(ABC) transporter
DN399_RS12415	COG1136	(ABC) transporter
DN399_RS12420	COG0577	efflux transmembrane transporter activity
DN399_RS12440	COG0460	homoserine dehydrogenase
DN399_RS12445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN399_RS12455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DN399_RS12485	COG0582	viral genome integration into host DNA
DN399_RS12595	COG0582	viral genome integration into host DNA
DN399_RS12655	COG0740	serine-type endopeptidase activity
DN399_RS12735	COG4824	toxin secretion phage lysis holin
DN399_RS12790	COG2124	cytochrome p450
DN399_RS12830	COG0561	phosphatase activity
DN399_RS12835	COG5002	protein histidine kinase activity
DN399_RS12840	COG0768	penicillin binding
DN399_RS12850	COG1819	glycosyl
DN399_RS12855	COG1794	racemase activity, acting on amino acids and derivatives
DN399_RS12880	COG2205	protein histidine kinase activity
DN399_RS12995	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DN399_RS13005	COG0745	RESPONSE REGULATOR receiver
DN399_RS13010	COG5002	protein histidine kinase activity
DN399_RS13015	COG0604	alcohol dehydrogenase
DN399_RS13020	COG0671	phosphoesterase, PA-phosphatase related
DN399_RS13025	COG0768	penicillin binding
DN399_RS13065	COG0693	protein deglycase activity
DN399_RS13080	COG0584	glycerophosphoryl diester phosphodiesterase
DN399_RS13100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN399_RS13105	COG0697	spore germination
DN399_RS13140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN399_RS13145	COG2223	nitrite transmembrane transporter activity
DN399_RS13160	COG0592	DNA-directed DNA polymerase activity
DN399_RS13180	COG3878	Protein conserved in bacteria
DN399_RS13190	COG3693	PFAM glycoside hydrolase, family 10
DN399_RS13190	COG3507	Belongs to the glycosyl hydrolase 43 family
DN399_RS13190	COG2382	esterase
DN399_RS13205	COG4667	esterase of the alpha-beta hydrolase superfamily
DN399_RS13245	COG0322	excinuclease ABC activity
DN399_RS13285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN399_RS13320	COG1011	Hydrolase
DN399_RS13325	COG0745	RESPONSE REGULATOR receiver
DN399_RS13330	COG5002	protein histidine kinase activity
DN399_RS13345	COG1136	(ABC) transporter
DN399_RS13350	COG0577	efflux transmembrane transporter activity
DN399_RS13355	COG1073	alpha beta
DN399_RS13360	COG0657	acetylesterase activity
DN399_RS13365	COG0076	glutamate decarboxylase activity
DN399_RS13380	COG1523	belongs to the glycosyl hydrolase 13 family
DN399_RS13385	COG3227	Zinc metalloprotease (Elastase)
DN399_RS13390	COG0737	Belongs to the 5'-nucleotidase family
DN399_RS13410	COG0201	protein transport
DN399_RS13415	COG0697	spore germination
DN399_RS13420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN399_RS13425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DN399_RS13455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS13470	COG2959	enzyme of heme biosynthesis
DN399_RS13515	COG1309	transcriptional regulator
DN399_RS13540	COG3284	Transcriptional regulator
DN399_RS13555	COG1349	DNA-binding transcription factor activity
DN399_RS13570	COG1959	2 iron, 2 sulfur cluster binding
DN399_RS13585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DN399_RS13590	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN399_RS13595	COG0022	dehydrogenase e1 component
DN399_RS13600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DN399_RS13610	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS13640	COG4176	ABC-type proline glycine betaine transport system permease component
DN399_RS13645	COG0517	IMP dehydrogenase activity
DN399_RS13645	COG4175	Glycine betaine
DN399_RS13675	COG2153	protein acetylation
DN399_RS13680	COG3397	chitin binding
DN399_RS13685	COG1819	glycosyl
DN399_RS13705	COG2205	protein histidine kinase activity
DN399_RS13710	COG2226	methyltransferase
DN399_RS13715	COG2315	Protein conserved in bacteria
DN399_RS13760	COG0456	acetyltransferase
DN399_RS13765	COG3973	AAA domain
DN399_RS13780	COG0514	ATP-dependent DNA helicase (RecQ)
DN399_RS13815	COG4637	Psort location Cytoplasmic, score
DN399_RS13835	COG3397	chitin binding
DN399_RS13850	COG1162	GTPase activity
DN399_RS13855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DN399_RS13860	COG1115	amino acid carrier protein
DN399_RS13865	COG1012	belongs to the aldehyde dehydrogenase family
DN399_RS13870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN399_RS13880	COG3938	Belongs to the proline racemase family
DN399_RS13885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DN399_RS13925	COG0586	Pfam SNARE associated Golgi protein
DN399_RS13935	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DN399_RS13945	COG4166	transmembrane transport
DN399_RS13955	COG4948	Mandelate Racemase Muconate Lactonizing
DN399_RS13970	COG0667	Aldo Keto reductase
DN399_RS14015	COG3850	Histidine kinase
DN399_RS14015	COG5002	protein histidine kinase activity
DN399_RS14020	COG0745	RESPONSE REGULATOR receiver
DN399_RS14055	COG1164	Oligoendopeptidase f
DN399_RS14060	COG1307	EDD domain protein, DegV family
DN399_RS14100	COG2814	Major facilitator Superfamily
DN399_RS14110	COG1664	Polymer-forming cytoskeletal
DN399_RS14115	COG0789	Transcriptional regulator
DN399_RS14120	COG4533	DNA binding
DN399_RS14125	COG0477	Major facilitator Superfamily
DN399_RS14125	COG2814	Major facilitator Superfamily
DN399_RS14145	COG2261	transglycosylase associated protein
DN399_RS14160	COG2226	methyltransferase
DN399_RS14195	COG0436	Aminotransferase
DN399_RS14200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DN399_RS14210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DN399_RS14250	COG0628	permease
DN399_RS14260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN399_RS14265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN399_RS14270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN399_RS14310	COG2746	aminoglycoside 3-N-acetyltransferase activity
DN399_RS14330	COG0697	spore germination
DN399_RS14360	COG4912	Dna alkylation repair
DN399_RS14365	COG0346	lactoylglutathione lyase activity
DN399_RS14385	COG0861	Integral membrane protein TerC family
DN399_RS14390	COG1368	sulfuric ester hydrolase activity
DN399_RS14395	COG0488	(ABC) transporter
DN399_RS14400	COG1033	growth of symbiont in host cell
DN399_RS14400	COG2409	Drug exporters of the RND superfamily
DN399_RS14405	COG1309	transcriptional regulator
DN399_RS14420	COG0287	Prephenate dehydrogenase
DN399_RS14435	COG1605	Chorismate mutase
DN399_RS14435	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DN399_RS14485	COG1388	LysM domain
DN399_RS14485	COG3584	3D domain protein
DN399_RS14495	COG0346	lactoylglutathione lyase activity
DN399_RS14500	COG0277	FAD linked oxidase domain protein
DN399_RS14525	COG1879	ABC-type sugar transport system periplasmic component
DN399_RS14530	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN399_RS14535	COG1172	Belongs to the binding-protein-dependent transport system permease family
DN399_RS14545	COG2390	Transcriptional regulator
DN399_RS14550	COG1070	Carbohydrate kinase
DN399_RS14570	COG2329	Antibiotic biosynthesis monooxygenase
DN399_RS14590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN399_RS14605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN399_RS14610	COG4187	Peptidase family M20/M25/M40
DN399_RS14615	COG1414	Transcriptional regulator
DN399_RS14625	COG0833	amino acid
DN399_RS14635	COG3239	Fatty acid desaturase
DN399_RS14645	COG2720	vancomycin resistance protein
DN399_RS14650	COG1785	Belongs to the alkaline phosphatase family
DN399_RS14660	COG3655	Transcriptional regulator
DN399_RS14675	COG4377	Putative membrane peptidase family (DUF2324)
DN399_RS14685	COG3279	Response regulator of the LytR AlgR family
DN399_RS14695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS14700	COG0346	lactoylglutathione lyase activity
DN399_RS14730	COG0714	Associated with various cellular activities
DN399_RS14755	COG0463	Glycosyl transferase, family 2
DN399_RS14785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DN399_RS14790	COG0753	catalase activity
DN399_RS14830	COG0714	Associated with various cellular activities
DN399_RS14875	COG0778	Nitroreductase
DN399_RS14880	COG1846	Transcriptional regulator
DN399_RS14905	COG4884	unkown
DN399_RS14905	COG3831	ATPase activity
DN399_RS14930	COG0456	acetyltransferase
DN399_RS14945	COG0697	spore germination
DN399_RS14950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN399_RS14990	COG0730	response to heat
DN399_RS15000	COG0833	amino acid
DN399_RS15010	COG4335	DNA alkylation repair
DN399_RS15070	COG0768	penicillin binding
DN399_RS15100	COG1984	allophanate hydrolase subunit 2
DN399_RS15105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DN399_RS15110	COG1414	Transcriptional regulator
DN399_RS15125	COG0640	Transcriptional regulator
DN399_RS15135	COG1960	acyl-CoA dehydrogenase activity
DN399_RS15150	COG3314	Sporulation integral membrane protein YlbJ
DN399_RS15170	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DN399_RS15195	COG0574	Belongs to the PEP-utilizing enzyme family
DN399_RS15195	COG3848	Pyruvate phosphate dikinase
DN399_RS15200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS15220	COG1063	alcohol dehydrogenase
DN399_RS15225	COG1027	Aspartate ammonia-lyase
DN399_RS15230	COG0252	asparaginase activity
DN399_RS15235	COG1396	sequence-specific DNA binding
DN399_RS15270	COG5002	protein histidine kinase activity
DN399_RS15295	COG2207	Transcriptional regulator
DN399_RS15320	COG0531	amino acid
DN399_RS15325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN399_RS15335	COG0531	amino acid
DN399_RS15340	COG0697	spore germination
DN399_RS15345	COG0784	Response regulator, receiver
DN399_RS15350	COG4191	Histidine kinase
DN399_RS15355	COG2066	Belongs to the glutaminase family
DN399_RS15360	COG1115	amino acid carrier protein
DN399_RS15390	COG0737	Belongs to the 5'-nucleotidase family
DN399_RS15395	COG2267	carboxylic ester hydrolase activity
DN399_RS15400	COG1335	isochorismatase
DN399_RS15420	COG0583	DNA-binding transcription factor activity
DN399_RS15425	COG1846	Transcriptional regulator
DN399_RS15430	COG0598	Magnesium transport protein CorA
DN399_RS15450	COG1073	alpha beta
DN399_RS15470	COG0415	Belongs to the DNA photolyase family
DN399_RS15485	COG0288	reversible hydration of carbon dioxide
DN399_RS15495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DN399_RS15500	COG5609	conserved protein (DUF2294)
DN399_RS15515	COG0456	acetyltransferase
DN399_RS15520	COG1575	Belongs to the MenA family. Type 1 subfamily
DN399_RS15535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DN399_RS15545	COG2814	Major facilitator Superfamily
DN399_RS15560	COG3320	Male sterility
DN399_RS15560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN399_RS15565	COG1309	transcriptional regulator
DN399_RS15570	COG2814	Major facilitator Superfamily
DN399_RS15575	COG1309	transcriptional regulator
DN399_RS15580	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS15585	COG1522	sequence-specific DNA binding
DN399_RS15600	COG0346	lactoylglutathione lyase activity
DN399_RS15655	COG2814	Major facilitator Superfamily
DN399_RS15670	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DN399_RS15680	COG1690	Belongs to the RtcB family
DN399_RS15690	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DN399_RS15710	COG0577	efflux transmembrane transporter activity
DN399_RS15730	COG3850	Histidine kinase
DN399_RS15730	COG5002	protein histidine kinase activity
DN399_RS15740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS15750	COG1619	proteins homologs of microcin C7 resistance protein MccF
DN399_RS15775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN399_RS15820	COG3409	Peptidoglycan-binding domain 1 protein
DN399_RS15820	COG5632	N-Acetylmuramoyl-L-alanine amidase
DN399_RS15925	COG1876	peptidase activity
DN399_RS15930	COG2843	Capsule synthesis protein
DN399_RS15940	COG0477	Major facilitator Superfamily
DN399_RS15955	COG1846	Transcriptional regulator
DN399_RS15960	COG2814	Major facilitator Superfamily
DN399_RS15970	COG2031	fatty acid transporter
DN399_RS15980	COG2249	NAD(P)H dehydrogenase (quinone) activity
DN399_RS16035	COG1288	antiporter activity
DN399_RS16040	COG2356	endonuclease I
DN399_RS16065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DN399_RS16085	COG1733	regulation of RNA biosynthetic process
DN399_RS16090	COG0778	Nitroreductase
DN399_RS16100	COG0469	pyruvate kinase activity
DN399_RS16120	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS16130	COG1131	(ABC) transporter
DN399_RS16160	COG1011	Hydrolase
DN399_RS16170	COG2365	Tyrosine phosphatase family
DN399_RS16205	COG0628	permease
DN399_RS16230	COG0500	methyltransferase
DN399_RS16270	COG1253	flavin adenine dinucleotide binding
DN399_RS16275	COG0789	Transcriptional regulator
DN399_RS16285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DN399_RS16315	COG0697	spore germination
DN399_RS16325	COG1357	PFAM Pentapeptide repeats (8 copies)
DN399_RS16330	COG3813	Protein conserved in bacteria
DN399_RS16335	COG2706	6-phosphogluconolactonase activity
DN399_RS16340	COG1070	Carbohydrate kinase
DN399_RS16350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DN399_RS16355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DN399_RS16365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DN399_RS16370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DN399_RS16380	COG0604	alcohol dehydrogenase
DN399_RS16385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DN399_RS16390	COG0789	Transcriptional regulator
DN399_RS16395	COG4221	oxidoreductase activity
DN399_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS16420	COG0840	transmembrane signaling receptor activity
DN399_RS16430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DN399_RS16430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DN399_RS16435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN399_RS16435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DN399_RS16440	COG1733	regulation of RNA biosynthetic process
DN399_RS16455	COG0656	L-ascorbic acid biosynthetic process
DN399_RS16460	COG2814	Major facilitator Superfamily
DN399_RS16485	COG2824	Alkylphosphonate utilization operon protein PhnA
DN399_RS16490	COG0659	secondary active sulfate transmembrane transporter activity
DN399_RS16505	COG0814	amino acid
DN399_RS16540	COG1733	regulation of RNA biosynthetic process
DN399_RS16545	COG2188	Transcriptional regulator
DN399_RS16550	COG0673	inositol 2-dehydrogenase activity
DN399_RS16555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DN399_RS16560	COG1733	regulation of RNA biosynthetic process
DN399_RS16565	COG1733	regulation of RNA biosynthetic process
DN399_RS16590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS16610	COG0384	phenazine biosynthesis protein PhzF
DN399_RS16615	COG0318	PFAM AMP-dependent synthetase and ligase
DN399_RS16620	COG2249	NAD(P)H dehydrogenase (quinone) activity
DN399_RS16625	COG1733	regulation of RNA biosynthetic process
DN399_RS16645	COG1191	sigma factor activity
DN399_RS16660	COG3226	Transcriptional regulator
DN399_RS16665	COG0076	glutamate decarboxylase activity
DN399_RS16690	COG1280	lysine exporter protein (LysE YggA)
DN399_RS16735	COG1151	hydroxylamine reductase activity
DN399_RS16765	COG2072	flavoprotein involved in K transport
DN399_RS16805	COG1113	amino acid transport
DN399_RS16810	COG2814	Major facilitator Superfamily
DN399_RS16850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN399_RS16855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DN399_RS16865	COG1247	-acetyltransferase
DN399_RS16870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN399_RS16875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS16880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS16885	COG3739	integral membrane protein
DN399_RS16905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS16920	COG0583	DNA-binding transcription factor activity
DN399_RS16940	COG1193	negative regulation of DNA recombination
DN399_RS16950	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DN399_RS16955	COG1164	Oligoendopeptidase f
DN399_RS16980	COG3781	membrane
DN399_RS17000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN399_RS17025	COG0584	glycerophosphoryl diester phosphodiesterase
DN399_RS17035	COG0640	Transcriptional regulator
DN399_RS17040	COG0604	alcohol dehydrogenase
DN399_RS17050	COG0457	Tetratricopeptide repeat
DN399_RS17065	COG0277	FAD linked oxidase domain protein
DN399_RS17090	COG1183	phosphatidylcholine synthase activity
DN399_RS17100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS17100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN399_RS17105	COG1252	NADH dehydrogenase
DN399_RS17115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DN399_RS17125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DN399_RS17140	COG0457	Tetratricopeptide repeat
DN399_RS17170	COG1309	transcriptional regulator
DN399_RS17205	COG3852	Histidine kinase
DN399_RS17215	COG1285	pathogenesis
DN399_RS17225	COG2514	catechol 2,3-dioxygenase activity
DN399_RS17230	COG2720	vancomycin resistance protein
DN399_RS17265	COG0716	FMN binding
DN399_RS17275	COG0494	nUDIX hydrolase
DN399_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS17305	COG0165	Argininosuccinate lyase
DN399_RS17320	COG4145	pantothenate transmembrane transporter activity
DN399_RS17330	COG1012	belongs to the aldehyde dehydrogenase family
DN399_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS17345	COG1657	PFAM Prenyltransferase squalene oxidase
DN399_RS17350	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DN399_RS17355	COG2962	Rard protein
DN399_RS17360	COG3326	Membrane
DN399_RS17375	COG0489	protein tyrosine kinase activity
DN399_RS17385	COG0314	molybdopterin synthase activity
DN399_RS17390	COG0303	'Molybdopterin
DN399_RS17395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DN399_RS17400	COG2116	formate transmembrane transporter activity
DN399_RS17410	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DN399_RS17415	COG5609	conserved protein (DUF2294)
DN399_RS17420	COG2427	Protein of unknown function (DUF1641)
DN399_RS17425	COG3383	formate dehydrogenase (NAD+) activity
DN399_RS17430	COG0697	spore germination
DN399_RS17445	COG0531	amino acid
DN399_RS17480	COG2226	methyltransferase
DN399_RS17485	COG4166	transmembrane transport
DN399_RS17490	COG4166	transmembrane transport
DN399_RS17495	COG4166	transmembrane transport
DN399_RS17500	COG1301	dicarboxylic acid transport
DN399_RS17505	COG1316	TRANSCRIPTIONal
DN399_RS17515	COG1595	DNA-templated transcription, initiation
DN399_RS17525	COG1131	(ABC) transporter
DN399_RS17535	COG0673	inositol 2-dehydrogenase activity
DN399_RS17540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DN399_RS17545	COG0187	DNA topoisomerase II activity
DN399_RS17550	COG1832	CoA-binding protein
DN399_RS17555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN399_RS17560	COG0745	RESPONSE REGULATOR receiver
DN399_RS17580	COG4841	protein insertion into membrane
DN399_RS17585	COG0824	Thioesterase
DN399_RS17615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN399_RS17625	COG2274	protein secretion by the type I secretion system
DN399_RS17630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DN399_RS17660	COG2211	Major facilitator Superfamily
DN399_RS17670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DN399_RS17685	COG0183	Belongs to the thiolase family
DN399_RS17690	COG0318	PFAM AMP-dependent synthetase and ligase
DN399_RS17695	COG1268	BioY protein
DN399_RS17700	COG0318	PFAM AMP-dependent synthetase and ligase
DN399_RS17730	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DN399_RS17750	COG0830	nickel cation binding
DN399_RS17790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS17805	COG5002	protein histidine kinase activity
DN399_RS17810	COG0400	carboxylic ester hydrolase activity
DN399_RS17815	COG0346	lactoylglutathione lyase activity
DN399_RS17820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DN399_RS17830	COG0069	glutamate synthase activity
DN399_RS17835	COG1902	pentaerythritol trinitrate reductase activity
DN399_RS17840	COG1329	Transcriptional regulator
DN399_RS17845	COG0010	Belongs to the arginase family
DN399_RS17900	COG4846	Membrane protein involved in cytochrome C biogenesis
DN399_RS17905	COG0785	Cytochrome C biogenesis protein
DN399_RS17920	COG1473	amidohydrolase
DN399_RS17930	COG1131	(ABC) transporter
DN399_RS17945	COG0583	DNA-binding transcription factor activity
DN399_RS17955	COG1346	cytolysis
DN399_RS17970	COG0730	response to heat
DN399_RS17995	COG1132	(ABC) transporter
DN399_RS18000	COG1132	(ABC) transporter
DN399_RS18025	COG3639	organic phosphonate transmembrane transporter activity
DN399_RS18035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN399_RS18040	COG0737	Belongs to the 5'-nucleotidase family
DN399_RS18050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DN399_RS18070	COG1695	Transcriptional regulator
DN399_RS18080	COG1388	LysM domain
DN399_RS18080	COG5632	N-Acetylmuramoyl-L-alanine amidase
DN399_RS18080	COG3409	Peptidoglycan-binding domain 1 protein
DN399_RS18085	COG0739	heme binding
DN399_RS18090	COG0741	lytic transglycosylase activity
DN399_RS18120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DN399_RS18125	COG0174	glutamine synthetase
DN399_RS18130	COG0789	Transcriptional regulator
DN399_RS18135	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DN399_RS18140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DN399_RS18145	COG2860	membrane
DN399_RS18150	COG0464	growth
DN399_RS18180	COG1388	LysM domain
DN399_RS18180	COG3584	3D domain protein
DN399_RS18185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN399_RS18185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN399_RS18185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN399_RS18190	COG1105	Belongs to the carbohydrate kinase PfkB family
DN399_RS18195	COG1349	DNA-binding transcription factor activity
DN399_RS18200	COG1979	alcohol dehydrogenase
DN399_RS18205	COG2322	membrane
DN399_RS18215	COG1113	amino acid transport
DN399_RS18230	COG1408	metallophosphoesterase
DN399_RS18235	COG2116	formate transmembrane transporter activity
DN399_RS18250	COG2217	Heavy metal translocating P-type atpase
DN399_RS18255	COG2608	mercury ion transmembrane transporter activity
DN399_RS18260	COG1937	Protein conserved in bacteria
DN399_RS18270	COG2819	hydrolase of the alpha beta superfamily
DN399_RS18275	COG1120	ATPase activity
DN399_RS18280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS18285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS18290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN399_RS18300	COG2169	Transcriptional regulator
DN399_RS18305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DN399_RS18310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DN399_RS18320	COG2364	Membrane
DN399_RS18335	COG2267	carboxylic ester hydrolase activity
DN399_RS18340	COG5001	Diguanylate cyclase
DN399_RS18340	COG3300	MHYT domain
DN399_RS18380	COG1346	cytolysis
DN399_RS18390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN399_RS18400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DN399_RS18415	COG1404	Belongs to the peptidase S8 family
DN399_RS18420	COG3773	Cell wall hydrolase
DN399_RS18435	COG1368	sulfuric ester hydrolase activity
DN399_RS18440	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DN399_RS18465	COG4550	Control of competence regulator ComK, YlbF/YmcA
DN399_RS18475	COG1013	pyruvate-flavodoxin oxidoreductase activity
DN399_RS18480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DN399_RS18480	COG0674	pyruvate-flavodoxin oxidoreductase activity
DN399_RS18490	COG2359	stage V sporulation protein S
DN399_RS18495	COG1692	metallophosphoesterase
DN399_RS18515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DN399_RS18520	COG1426	Protein conserved in bacteria
DN399_RS18535	COG0300	oxidoreductase activity
DN399_RS18540	COG0612	Peptidase, M16
DN399_RS18545	COG0612	Peptidase, M16
DN399_RS18550	COG1079	Belongs to the binding-protein-dependent transport system permease family
DN399_RS18555	COG4603	Belongs to the binding-protein-dependent transport system permease family
DN399_RS18560	COG3845	ABC transporter
DN399_RS18565	COG1744	ABC transporter substrate-binding protein PnrA-like
DN399_RS18570	COG2188	Transcriptional regulator
DN399_RS18590	COG0740	serine-type endopeptidase activity
DN399_RS18595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DN399_RS18605	COG0527	aspartate kinase activity
DN399_RS18610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DN399_RS18615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DN399_RS18620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN399_RS18625	COG1873	PFAM PRC-barrel domain
DN399_RS18630	COG0612	Peptidase, M16
DN399_RS18635	COG0726	polysaccharide deacetylase
DN399_RS18650	COG0196	riboflavin kinase activity
DN399_RS18660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DN399_RS18665	COG1550	Protein conserved in bacteria
DN399_RS18675	COG1358	cellular component organization or biogenesis
DN399_RS18680	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DN399_RS18685	COG0195	Participates in both transcription termination and antitermination
DN399_RS18705	COG0750	zinc metalloprotease
DN399_RS18715	COG4589	Belongs to the CDS family
DN399_RS18760	COG4974	Belongs to the 'phage' integrase family
DN399_RS18770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN399_RS18775	COG0758	DNA mediated transformation
DN399_RS18780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DN399_RS18820	COG1837	Belongs to the UPF0109 family
DN399_RS18830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DN399_RS18840	COG0552	protein localization to endoplasmic reticulum
DN399_RS18845	COG1196	nuclear chromosome segregation
DN399_RS18855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN399_RS18860	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS18865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DN399_RS18880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DN399_RS18885	COG1461	Dihydroxyacetone kinase
DN399_RS18890	COG1302	Protein conserved in bacteria
DN399_RS18905	COG1564	THIamine pyrophosphokinase
DN399_RS18910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DN399_RS18920	COG2815	serine threonine protein kinase
DN399_RS18920	COG0515	serine threonine protein kinase
DN399_RS18925	COG0631	protein serine/threonine phosphatase activity
DN399_RS18935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DN399_RS18935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DN399_RS18950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DN399_RS18955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DN399_RS18975	COG1561	YicC-like family, N-terminal region
DN399_RS18980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN399_RS18990	COG0006	proline dipeptidase activity
DN399_RS19005	COG3069	C4-dicarboxylate transmembrane transporter activity
DN399_RS19065	COG0564	pseudouridine synthase activity
DN399_RS19085	COG3599	regulation of cell shape
DN399_RS19090	COG2302	S4 RNA-binding domain
DN399_RS19095	COG0762	integral membrane protein
DN399_RS19105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DN399_RS19115	COG1873	PFAM PRC-barrel domain
DN399_RS19120	COG1191	sigma factor activity
DN399_RS19125	COG1191	sigma factor activity
DN399_RS19135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DN399_RS19140	COG0849	cell division
DN399_RS19160	COG0772	Belongs to the SEDS family
DN399_RS19180	COG0768	penicillin binding
DN399_RS19185	COG0768	penicillin binding
DN399_RS19205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DN399_RS19220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DN399_RS19225	COG1399	metal-binding, possibly nucleic acid-binding protein
DN399_RS19235	COG3480	Lon protease (S16) C-terminal proteolytic domain
DN399_RS19240	COG1752	Esterase of the alpha-beta hydrolase superfamily
DN399_RS19245	COG3314	Sporulation integral membrane protein YlbJ
DN399_RS19255	COG0742	ribosomal rna small subunit methyltransferase
DN399_RS19270	COG3679	Belongs to the UPF0342 family
DN399_RS19275	COG0406	alpha-ribazole phosphatase activity
DN399_RS19290	COG2340	Cysteine-rich secretory protein family
DN399_RS19305	COG3336	cytochrome c oxidase
DN399_RS19340	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DN399_RS19350	COG0772	Belongs to the SEDS family
DN399_RS19360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DN399_RS19365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DN399_RS19375	COG4896	Protein conserved in bacteria
DN399_RS19390	COG1217	gtp-binding protein TYPA
DN399_RS19400	COG0483	inositol monophosphate 1-phosphatase activity
DN399_RS19420	COG1982	Orn Lys Arg decarboxylase major
DN399_RS19470	COG0022	dehydrogenase e1 component
DN399_RS19475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DN399_RS19490	COG0561	phosphatase activity
DN399_RS19505	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DN399_RS19510	COG0569	domain protein
DN399_RS19530	COG0583	DNA-binding transcription factor activity
DN399_RS19535	COG0517	IMP dehydrogenase activity
DN399_RS19545	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DN399_RS19550	COG4703	Protein of unknown function (DUF1797)
DN399_RS19565	COG2200	EAL domain
DN399_RS19570	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS19575	COG1408	metallophosphoesterase
DN399_RS19620	COG2814	Major facilitator Superfamily
DN399_RS19640	COG3209	COG3209 Rhs family protein
DN399_RS19650	COG2205	protein histidine kinase activity
DN399_RS19660	COG0436	Aminotransferase
DN399_RS19665	COG1609	Transcriptional regulator
DN399_RS19670	COG3833	ABC-type maltose transport systems, permease component
DN399_RS19675	COG1175	transmembrane transport
DN399_RS19680	COG2182	Extracellular solute-binding protein
DN399_RS19690	COG0366	Alpha amylase catalytic
DN399_RS19695	COG3842	ATPase activity
DN399_RS19735	COG0183	Belongs to the thiolase family
DN399_RS19770	COG1695	Transcriptional regulator
DN399_RS19775	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS19795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DN399_RS19800	COG0436	Aminotransferase
DN399_RS19835	COG2084	Dehydrogenase
DN399_RS19845	COG2199	diguanylate cyclase activity
DN399_RS19850	COG0778	Nitroreductase
DN399_RS19875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN399_RS19875	COG2190	(PTS) system
DN399_RS19875	COG1263	PTS System
DN399_RS19880	COG3711	transcriptional antiterminator
DN399_RS19890	COG2188	Transcriptional regulator
DN399_RS19900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DN399_RS19930	COG1547	Domain of unknown function (DUF309)
DN399_RS19935	COG0456	acetyltransferase
DN399_RS19940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DN399_RS19945	COG4086	secreted protein
DN399_RS19950	COG0561	phosphatase activity
DN399_RS19955	COG0697	spore germination
DN399_RS19970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN399_RS19995	COG0733	neurotransmitter:sodium symporter activity
DN399_RS20015	COG1686	Belongs to the peptidase S11 family
DN399_RS20025	COG1725	Transcriptional regulator
DN399_RS20030	COG1131	(ABC) transporter
DN399_RS20050	COG1846	Transcriptional regulator
DN399_RS20065	COG0598	Magnesium transport protein CorA
DN399_RS20090	COG4974	Belongs to the 'phage' integrase family
DN399_RS20100	COG0735	belongs to the Fur family
DN399_RS20105	COG1300	Membrane
DN399_RS20125	COG0667	Aldo Keto reductase
DN399_RS20130	COG0656	L-ascorbic acid biosynthetic process
DN399_RS20135	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DN399_RS20135	COG0456	acetyltransferase
DN399_RS20145	COG0737	Belongs to the 5'-nucleotidase family
DN399_RS20145	COG4085	toxin activity
DN399_RS20145	COG1525	nuclease
DN399_RS20155	COG0596	Alpha beta hydrolase
DN399_RS20160	COG2056	Na+-H+ antiporter family
DN399_RS20165	COG1609	Transcriptional regulator
DN399_RS20170	COG0456	acetyltransferase
DN399_RS20175	COG1073	alpha beta
DN399_RS20190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DN399_RS20190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DN399_RS20195	COG0307	riboflavin synthase, alpha
DN399_RS20225	COG2226	methyltransferase
DN399_RS20225	COG1073	alpha beta
DN399_RS20240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DN399_RS20250	COG1757	Na H antiporter
DN399_RS20255	COG0737	Belongs to the 5'-nucleotidase family
DN399_RS20265	COG1522	sequence-specific DNA binding
DN399_RS20310	COG0300	oxidoreductase activity
DN399_RS20315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS20320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN399_RS20325	COG1760	l-serine dehydratase
DN399_RS20330	COG1760	l-serine dehydratase
DN399_RS20370	COG2195	Cleaves the N-terminal amino acid of tripeptides
DN399_RS20375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS20390	COG1376	ErfK ybiS ycfS ynhG family protein
DN399_RS20395	COG4129	membrane
DN399_RS20400	COG1126	abc transporter atp-binding protein
DN399_RS20405	COG0765	amino acid transport
DN399_RS20410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN399_RS20430	COG2323	membrane
DN399_RS20435	COG0772	Belongs to the SEDS family
DN399_RS20440	COG0508	dehydrogenase complex catalyzes the overall conversion of
DN399_RS20445	COG0022	dehydrogenase e1 component
DN399_RS20450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DN399_RS20455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DN399_RS20470	COG0280	phosphate acetyltransferase
DN399_RS20480	COG3290	protein histidine kinase activity
DN399_RS20480	COG3829	transcription factor binding
DN399_RS20490	COG0584	glycerophosphoryl diester phosphodiesterase
DN399_RS20495	COG3093	addiction module antidote protein HigA
DN399_RS20515	COG0750	zinc metalloprotease
DN399_RS20520	COG0497	DNA recombination
DN399_RS20530	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DN399_RS20540	COG0142	geranyltranstransferase activity
DN399_RS20565	COG1302	Protein conserved in bacteria
DN399_RS20570	COG0439	Biotin carboxylase
DN399_RS20575	COG0511	ligase activity, forming carbon-carbon bonds
DN399_RS20620	COG3854	ATPases associated with a variety of cellular activities
DN399_RS20645	COG0006	proline dipeptidase activity
DN399_RS20660	COG3872	metal-dependent enzyme
DN399_RS20670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN399_RS20685	COG1695	Transcriptional regulator
DN399_RS20705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN399_RS20715	COG1609	Transcriptional regulator
DN399_RS20725	COG2076	Multidrug Resistance protein
DN399_RS20730	COG2076	Multidrug Resistance protein
DN399_RS20760	COG1131	(ABC) transporter
DN399_RS20765	COG1725	Transcriptional regulator
DN399_RS20800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN399_RS20850	COG1204	response to ionizing radiation
DN399_RS20950	COG0646	methionine synthase
DN399_RS20950	COG1410	methionine synthase
DN399_RS20955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DN399_RS20955	COG0646	methionine synthase
DN399_RS20960	COG0626	cystathionine gamma-synthase activity
DN399_RS20965	COG0626	cystathionine gamma-synthase activity
DN399_RS20985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS20995	COG1940	carbohydrate kinase activity
DN399_RS21000	COG4483	Protein conserved in bacteria
DN399_RS21005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DN399_RS21010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DN399_RS21015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DN399_RS21020	COG0704	Plays a role in the regulation of phosphate uptake
DN399_RS21030	COG0573	inorganic phosphate transmembrane transporter activity
DN399_RS21035	COG0573	inorganic phosphate transmembrane transporter activity
DN399_RS21040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DN399_RS21045	COG0768	penicillin binding
DN399_RS21050	COG0477	Major facilitator Superfamily
DN399_RS21055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DN399_RS21065	COG5521	maltodextrose utilization protein MalA
DN399_RS21080	COG0735	belongs to the Fur family
DN399_RS21085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DN399_RS21090	COG1121	(ABC) transporter
DN399_RS21095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS21125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DN399_RS21130	COG2384	SAM-dependent methyltransferase
DN399_RS21140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DN399_RS21145	COG0358	DNA primase activity
DN399_RS21155	COG0517	IMP dehydrogenase activity
DN399_RS21170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DN399_RS21175	COG0295	cytidine deaminase activity
DN399_RS21180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DN399_RS21190	COG1480	7TM receptor with intracellular HD hydrolase
DN399_RS21195	COG1702	phosphate starvation-inducible protein PhoH
DN399_RS21215	COG1610	YqeY-like protein
DN399_RS21220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DN399_RS21225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN399_RS21230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DN399_RS21260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DN399_RS21265	COG1733	regulation of RNA biosynthetic process
DN399_RS21290	COG1466	dna polymerase III delta subunit
DN399_RS21300	COG0658	competence protein
DN399_RS21300	COG2333	competence protein COMEC
DN399_RS21305	COG2131	deaminase
DN399_RS21310	COG1555	photosystem II stabilization
DN399_RS21310	COG1596	polysaccharide export
DN399_RS21315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN399_RS21320	COG2226	methyltransferase
DN399_RS21325	COG0799	negative regulation of ribosome biogenesis
DN399_RS21330	COG1713	HD superfamily hydrolase involved in NAD metabolism
DN399_RS21340	COG1534	Rna-binding protein
DN399_RS21350	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DN399_RS21355	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DN399_RS21390	COG0778	Nitroreductase
DN399_RS21395	COG2357	RelA SpoT domain protein
DN399_RS21405	COG1785	Belongs to the alkaline phosphatase family
DN399_RS21415	COG2267	carboxylic ester hydrolase activity
DN399_RS21450	COG1404	Belongs to the peptidase S8 family
DN399_RS21455	COG3186	Phenylalanine-4-hydroxylase
DN399_RS21465	COG2514	catechol 2,3-dioxygenase activity
DN399_RS21470	COG2259	Doxx family
DN399_RS21510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN399_RS21525	COG1012	belongs to the aldehyde dehydrogenase family
DN399_RS21525	COG1454	alcohol dehydrogenase
DN399_RS21530	COG0626	cystathionine gamma-synthase activity
DN399_RS21535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DN399_RS21560	COG0768	penicillin binding
DN399_RS21580	COG0826	peptidase U32
DN399_RS21585	COG0826	peptidase U32
DN399_RS21590	COG4122	O-methyltransferase activity
DN399_RS21595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DN399_RS21625	COG0628	permease
DN399_RS21645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DN399_RS21660	COG1104	cysteine desulfurase activity
DN399_RS21665	COG1959	2 iron, 2 sulfur cluster binding
DN399_RS21670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DN399_RS21685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DN399_RS21705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DN399_RS21715	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DN399_RS21715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DN399_RS21720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DN399_RS21725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN399_RS21725	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN399_RS21735	COG2244	polysaccharide biosynthetic process
DN399_RS21740	COG2323	membrane
DN399_RS21750	COG1862	Preprotein translocase
DN399_RS21780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DN399_RS21810	COG0157	Belongs to the NadC ModD family
DN399_RS21815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DN399_RS21820	COG1104	cysteine desulfurase activity
DN399_RS21825	COG1827	regulation of RNA biosynthetic process
DN399_RS21830	COG2258	MOSC domain
DN399_RS21835	COG0077	Prephenate dehydratase
DN399_RS21840	COG0577	efflux transmembrane transporter activity
DN399_RS21845	COG0577	efflux transmembrane transporter activity
DN399_RS21850	COG1136	(ABC) transporter
DN399_RS21855	COG5002	protein histidine kinase activity
DN399_RS21860	COG0745	RESPONSE REGULATOR receiver
DN399_RS21870	COG3290	protein histidine kinase activity
DN399_RS21880	COG2868	ribosomal protein
DN399_RS21890	COG1530	ribonuclease E activity
DN399_RS21895	COG1994	Peptidase M50
DN399_RS21900	COG0739	heme binding
DN399_RS21905	COG2894	cell division
DN399_RS21925	COG1077	Cell shape determining protein MreB Mrl
DN399_RS21945	COG0285	dihydrofolate synthase activity
DN399_RS21960	COG1388	LysM domain
DN399_RS21970	COG0113	porphobilinogen synthase activity
DN399_RS21975	COG1587	Uroporphyrinogen-III synthase
DN399_RS21985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DN399_RS21995	COG1846	Transcriptional regulator
DN399_RS22000	COG1764	response to oxidative stress
DN399_RS22015	COG0470	DNA polymerase III
DN399_RS22015	COG1067	ATP-dependent peptidase activity
DN399_RS22060	COG0622	Phosphoesterase
DN399_RS22075	COG5401	PFAM Sporulation and spore germination
DN399_RS22090	COG2197	response regulator
DN399_RS22095	COG2233	PERMEase
DN399_RS22100	COG0402	S-adenosylhomocysteine deaminase activity
DN399_RS22105	COG1983	PspC domain protein
DN399_RS22110	COG1396	sequence-specific DNA binding
DN399_RS22115	COG0697	spore germination
DN399_RS22125	COG1959	2 iron, 2 sulfur cluster binding
DN399_RS22130	COG1668	transmembrane transport
DN399_RS22135	COG4152	abc transporter atp-binding protein
DN399_RS22140	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DN399_RS22145	COG1360	Flagellar Motor Protein
DN399_RS22150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DN399_RS22155	COG1876	peptidase activity
DN399_RS22160	COG0824	Thioesterase
DN399_RS22165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DN399_RS22170	COG1053	succinate dehydrogenase
DN399_RS22175	COG2009	succinate dehydrogenase
DN399_RS22180	COG1719	4-vinyl reductase, 4VR
DN399_RS22190	COG3118	belongs to the thioredoxin family
DN399_RS22195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DN399_RS22200	COG2086	electron transfer activity
DN399_RS22205	COG1024	Enoyl-CoA hydratase
DN399_RS22210	COG1309	transcriptional regulator
DN399_RS22215	COG0318	PFAM AMP-dependent synthetase and ligase
DN399_RS22245	COG2318	DinB family
DN399_RS22270	COG1131	(ABC) transporter
DN399_RS22275	COG2205	protein histidine kinase activity
DN399_RS22280	COG0745	RESPONSE REGULATOR receiver
DN399_RS22285	COG4895	conserved protein (DUF2196)
DN399_RS22290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DN399_RS22300	COG4509	Sortase family
DN399_RS22305	COG1120	ATPase activity
DN399_RS22320	COG5386	Cell surface protein
DN399_RS22330	COG5386	Cell surface protein
DN399_RS22335	COG1114	Component of the transport system for branched-chain amino acids
DN399_RS22340	COG1187	pseudouridine synthase activity
DN399_RS22350	COG1796	DNA polymerase
DN399_RS22350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DN399_RS22355	COG1286	toxin biosynthetic process
DN399_RS22395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DN399_RS22405	COG1418	mRNA catabolic process
DN399_RS22415	COG2814	Major facilitator Superfamily
DN399_RS22420	COG1566	PFAM secretion protein HlyD family protein
DN399_RS22425	COG1309	transcriptional regulator
DN399_RS22430	COG1363	Peptidase, m42
DN399_RS22455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN399_RS22470	COG1484	DNA-dependent DNA replication
DN399_RS22475	COG3611	Membrane attachment protein
DN399_RS22485	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DN399_RS22490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DN399_RS22500	COG1971	Probably functions as a manganese efflux pump
DN399_RS22510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN399_RS22510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN399_RS22515	COG5002	protein histidine kinase activity
DN399_RS22520	COG0745	RESPONSE REGULATOR receiver
DN399_RS22540	COG0538	isocitrate dehydrogenase activity
DN399_RS22545	COG0372	Belongs to the citrate synthase family
DN399_RS22560	COG0628	permease
DN399_RS22565	COG3030	protein affecting phage T7 exclusion by the F plasmid
DN399_RS22590	COG1725	Transcriptional regulator
DN399_RS22595	COG0281	malic enzyme
DN399_RS22600	COG0587	DNA-directed DNA polymerase activity
DN399_RS22615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DN399_RS22630	COG4109	DRTGG domain
DN399_RS22640	COG0006	proline dipeptidase activity
DN399_RS22675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS22680	COG0662	Cupin 2, conserved barrel domain protein
DN399_RS22695	COG1028	Short-chain dehydrogenase reductase Sdr
DN399_RS22700	COG0589	response to stress
DN399_RS22740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS22765	COG0827	DNA restriction-modification system
DN399_RS22770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DN399_RS22775	COG3874	Sporulation protein YtfJ
DN399_RS22790	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DN399_RS22800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DN399_RS22815	COG1104	cysteine desulfurase activity
DN399_RS22825	COG0583	DNA-binding transcription factor activity
DN399_RS22830	COG0697	spore germination
DN399_RS22835	COG1309	transcriptional regulator
DN399_RS22840	COG1956	GAF domain-containing protein
DN399_RS22845	COG0626	cystathionine gamma-synthase activity
DN399_RS22875	COG0110	maltose O-acetyltransferase activity
DN399_RS22880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DN399_RS22885	COG0454	-acetyltransferase
DN399_RS22890	COG0517	IMP dehydrogenase activity
DN399_RS22895	COG0123	including yeast histone deacetylase and acetoin utilization protein
DN399_RS22910	COG0745	RESPONSE REGULATOR receiver
DN399_RS22920	COG0666	response to abiotic stimulus
DN399_RS22955	COG1609	Transcriptional regulator
DN399_RS22960	COG1605	Chorismate mutase
DN399_RS22960	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DN399_RS22965	COG4851	CamS sex pheromone cAM373 precursor
DN399_RS22970	COG3118	belongs to the thioredoxin family
DN399_RS22980	COG2309	aminopeptidase activity
DN399_RS22995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS23010	COG1674	ftsk spoiiie
DN399_RS23015	COG0860	N-Acetylmuramoyl-L-alanine amidase
DN399_RS23015	COG1388	LysM domain
DN399_RS23025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN399_RS23035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN399_RS23040	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DN399_RS23045	COG1363	Peptidase, m42
DN399_RS23055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS23070	COG0510	thiamine kinase activity
DN399_RS23075	COG1523	belongs to the glycosyl hydrolase 13 family
DN399_RS23085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN399_RS23090	COG1349	DNA-binding transcription factor activity
DN399_RS23095	COG1187	pseudouridine synthase activity
DN399_RS23100	COG2244	polysaccharide biosynthetic process
DN399_RS23105	COG2081	HI0933 family
DN399_RS23110	COG2814	Major facilitator Superfamily
DN399_RS23120	COG3832	glyoxalase III activity
DN399_RS23145	COG1329	Transcriptional regulator
DN399_RS23170	COG0314	molybdopterin synthase activity
DN399_RS23175	COG1763	Mo-molybdopterin cofactor biosynthetic process
DN399_RS23180	COG0303	'Molybdopterin
DN399_RS23190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DN399_RS23195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DN399_RS23220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DN399_RS23230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DN399_RS23270	COG2814	Major facilitator Superfamily
DN399_RS23275	COG0475	glutathione-regulated potassium exporter activity
DN399_RS23280	COG0490	domain, Protein
DN399_RS23285	COG0582	viral genome integration into host DNA
DN399_RS23300	COG1136	(ABC) transporter
DN399_RS23320	COG1242	4 iron, 4 sulfur cluster binding
DN399_RS23325	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DN399_RS23350	COG2267	carboxylic ester hydrolase activity
DN399_RS23355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DN399_RS23360	COG0671	phosphoesterase, PA-phosphatase related
DN399_RS23365	COG0438	transferase activity, transferring glycosyl groups
DN399_RS23385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS23455	COG5002	protein histidine kinase activity
DN399_RS23460	COG3852	Histidine kinase
DN399_RS23465	COG0753	catalase activity
DN399_RS23475	COG2267	carboxylic ester hydrolase activity
DN399_RS23480	COG1368	sulfuric ester hydrolase activity
DN399_RS23495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN399_RS23500	COG1116	anion transmembrane transporter activity
DN399_RS23505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN399_RS23530	COG0494	nUDIX hydrolase
DN399_RS23565	COG1854	S-ribosylhomocysteine lyase activity
DN399_RS23575	COG0288	reversible hydration of carbon dioxide
DN399_RS23580	COG1271	oxidase subunit
DN399_RS23585	COG1294	oxidase, subunit
DN399_RS23600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS23620	COG1842	Phage shock protein A
DN399_RS23650	COG5002	protein histidine kinase activity
DN399_RS23655	COG0745	RESPONSE REGULATOR receiver
DN399_RS23680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DN399_RS23685	COG1597	lipid kinase activity
DN399_RS23750	COG0586	Pfam SNARE associated Golgi protein
DN399_RS23760	COG0577	efflux transmembrane transporter activity
DN399_RS23765	COG1136	(ABC) transporter
DN399_RS23770	COG3708	Transcriptional regulator
DN399_RS23770	COG2207	Transcriptional regulator
DN399_RS23780	COG5658	integral membrane protein
DN399_RS23785	COG0640	Transcriptional regulator
DN399_RS23790	COG0745	RESPONSE REGULATOR receiver
DN399_RS23795	COG2205	protein histidine kinase activity
DN399_RS23800	COG0577	efflux transmembrane transporter activity
DN399_RS23805	COG0577	efflux transmembrane transporter activity
DN399_RS23810	COG1136	(ABC) transporter
DN399_RS23815	COG0577	efflux transmembrane transporter activity
DN399_RS23840	COG2188	Transcriptional regulator
DN399_RS23860	COG3964	amidohydrolase
DN399_RS23880	COG4948	Mandelate Racemase Muconate Lactonizing
DN399_RS23890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DN399_RS23895	COG0596	Alpha beta hydrolase
DN399_RS23905	COG1169	isochorismate synthase
DN399_RS23910	COG1575	Belongs to the MenA family. Type 1 subfamily
DN399_RS23915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DN399_RS23935	COG0058	SHG alpha-glucan phosphorylase activity
DN399_RS23945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DN399_RS23965	COG1404	Belongs to the peptidase S8 family
DN399_RS23980	COG1309	transcriptional regulator
DN399_RS24080	COG0544	peptidyl-prolyl cis-trans isomerase activity
DN399_RS24115	COG1285	pathogenesis
DN399_RS24120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DN399_RS24140	COG2155	Conserved Protein
DN399_RS24145	COG1098	S1 RNA binding domain
DN399_RS24150	COG0436	Aminotransferase
DN399_RS24155	COG1522	sequence-specific DNA binding
DN399_RS24160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN399_RS24165	COG2267	carboxylic ester hydrolase activity
DN399_RS24175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DN399_RS24190	COG5018	Exonuclease
DN399_RS24195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DN399_RS24215	COG2050	protein possibly involved in aromatic compounds catabolism
DN399_RS24225	COG1268	BioY protein
DN399_RS24230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DN399_RS24235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN399_RS24255	COG2076	Multidrug Resistance protein
DN399_RS24260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DN399_RS24270	COG3584	3D domain protein
DN399_RS24285	COG1252	NADH dehydrogenase
DN399_RS24300	COG3708	Transcriptional regulator
DN399_RS24315	COG1683	Conserved Protein
DN399_RS24335	COG0316	Belongs to the HesB IscA family
DN399_RS24350	COG1252	NADH dehydrogenase
DN399_RS24360	COG2274	protein secretion by the type I secretion system
DN399_RS24365	COG0390	transport system, permease component
DN399_RS24370	COG2824	Alkylphosphonate utilization operon protein PhnA
DN399_RS24420	COG4837	Protein of unknown function (DUF1462)
DN399_RS24425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DN399_RS24435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DN399_RS24440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DN399_RS24460	COG1358	cellular component organization or biogenesis
DN399_RS24475	COG2249	NAD(P)H dehydrogenase (quinone) activity
DN399_RS24480	COG0647	UMP catabolic process
DN399_RS24490	COG2445	Protein of unknown function DUF86
DN399_RS24495	COG1494	fructose-1,6-bisphosphatase
DN399_RS24520	COG4470	Protein conserved in bacteria
DN399_RS24530	COG0789	Transcriptional regulator
DN399_RS24535	COG4377	Putative membrane peptidase family (DUF2324)
DN399_RS24560	COG0739	heme binding
DN399_RS24570	COG3377	Domain of unknown function (DUF1805)
DN399_RS24575	COG0737	Belongs to the 5'-nucleotidase family
DN399_RS24585	COG0719	Fe-S assembly protein
DN399_RS24590	COG0822	iron-sulfur transferase activity
DN399_RS24595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DN399_RS24600	COG0719	Fe-S assembly protein
DN399_RS24605	COG0396	ATPase activity
DN399_RS24610	COG1464	Belongs to the NlpA lipoprotein family
DN399_RS24615	COG1464	Belongs to the NlpA lipoprotein family
DN399_RS24620	COG2011	ABC-type metal ion transport system permease component
DN399_RS24635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DN399_RS24640	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DN399_RS24655	COG1393	Belongs to the ArsC family
DN399_RS24695	COG1309	transcriptional regulator
DN399_RS24700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN399_RS24705	COG1960	acyl-CoA dehydrogenase activity
DN399_RS24710	COG0183	Belongs to the thiolase family
DN399_RS24715	COG1024	Enoyl-CoA hydratase
DN399_RS24715	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN399_RS24725	COG1686	Belongs to the peptidase S11 family
DN399_RS24740	COG0011	TIGRFAM Protein of
DN399_RS24745	COG0840	transmembrane signaling receptor activity
DN399_RS24755	COG2814	Major facilitator Superfamily
DN399_RS24760	COG0531	amino acid
DN399_RS24785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN399_RS24825	COG0586	Pfam SNARE associated Golgi protein
DN399_RS24835	COG1376	ErfK ybiS ycfS ynhG family protein
DN399_RS24840	COG0745	RESPONSE REGULATOR receiver
DN399_RS24845	COG5002	protein histidine kinase activity
DN399_RS24875	COG0840	transmembrane signaling receptor activity
DN399_RS24880	COG2151	metal-sulfur cluster biosynthetic enzyme
DN399_RS24885	COG3227	Zinc metalloprotease (Elastase)
DN399_RS24905	COG0586	Pfam SNARE associated Golgi protein
DN399_RS24910	COG0475	glutathione-regulated potassium exporter activity
DN399_RS24915	COG0490	domain, Protein
DN399_RS24925	COG1115	amino acid carrier protein
DN399_RS24930	COG0783	Belongs to the Dps family
DN399_RS24955	COG1611	Belongs to the LOG family
DN399_RS24965	COG1528	Iron-storage protein
DN399_RS24975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN399_RS24980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN399_RS24985	COG1115	amino acid carrier protein
DN399_RS24990	COG1115	amino acid carrier protein
DN399_RS24995	COG2910	NAD(P)H-binding
DN399_RS25010	COG0656	L-ascorbic acid biosynthetic process
DN399_RS25015	COG2814	Major facilitator Superfamily
DN399_RS25020	COG1733	regulation of RNA biosynthetic process
DN399_RS25030	COG1252	NADH dehydrogenase
DN399_RS25050	COG0840	transmembrane signaling receptor activity
DN399_RS25050	COG3290	protein histidine kinase activity
DN399_RS25080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DN399_RS25170	COG5002	protein histidine kinase activity
DN399_RS25175	COG0745	RESPONSE REGULATOR receiver
DN399_RS25180	COG1136	(ABC) transporter
DN399_RS25200	COG1136	(ABC) transporter
DN399_RS25235	COG0557	exoribonuclease II activity
DN399_RS25240	COG1647	Serine aminopeptidase, S33
DN399_RS25245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DN399_RS25250	COG1346	cytolysis
DN399_RS25285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DN399_RS25300	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DN399_RS25325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DN399_RS25340	COG2323	membrane
DN399_RS25350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN399_RS25360	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DN399_RS25370	COG1051	belongs to the nudix hydrolase family
DN399_RS25380	COG0492	ferredoxin-NADP+ reductase activity
DN399_RS25385	COG0457	Tetratricopeptide repeat
DN399_RS25390	COG0110	maltose O-acetyltransferase activity
DN399_RS25410	COG1950	PFAM Membrane protein of
DN399_RS25420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DN399_RS25425	COG0556	nucleotide-excision repair
DN399_RS25440	COG0789	Transcriptional regulator
DN399_RS25460	COG0583	DNA-binding transcription factor activity
DN399_RS25470	COG0655	NAD(P)H dehydrogenase (quinone) activity
DN399_RS25475	COG0488	(ABC) transporter
DN399_RS25485	COG1132	(ABC) transporter
DN399_RS25490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN399_RS25495	COG3409	Peptidoglycan-binding domain 1 protein
DN399_RS25495	COG0793	Belongs to the peptidase S41A family
DN399_RS25500	COG2177	Part of the ABC transporter FtsEX involved in
DN399_RS25505	COG2884	Cell division ATP-binding protein ftsE
DN399_RS25530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DN399_RS25535	COG1278	Cold shock
DN399_RS25540	COG1040	competence protein
DN399_RS25545	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DN399_RS25550	COG0791	NLP P60 protein
DN399_RS25550	COG1388	LysM domain
DN399_RS25555	COG1733	regulation of RNA biosynthetic process
DN399_RS25560	COG1307	EDD domain protein, DegV family
DN399_RS25565	COG1739	Uncharacterized protein family UPF0029
DN399_RS25570	COG1316	TRANSCRIPTIONal
DN399_RS25575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DN399_RS25580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DN399_RS25585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DN399_RS25595	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DN399_RS25595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DN399_RS25615	COG1486	melibiose metabolic process
DN399_RS25620	COG1447	Phosphotransferase system cellobiose-specific component IIA
DN399_RS25625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DN399_RS25645	COG1447	Phosphotransferase system cellobiose-specific component IIA
DN399_RS25655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DN399_RS25660	COG1301	dicarboxylic acid transport
DN399_RS25675	COG1511	domain protein
DN399_RS25680	COG0583	DNA-binding transcription factor activity
DN399_RS25685	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DN399_RS25690	COG1271	oxidase subunit
DN399_RS25695	COG1294	oxidase, subunit
DN399_RS25700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DN399_RS25730	COG1620	l-lactate permease
DN399_RS25740	COG2389	metal-binding protein
DN399_RS25755	COG1368	sulfuric ester hydrolase activity
DN399_RS25765	COG0791	NLP P60 protein
DN399_RS25765	COG1388	LysM domain
DN399_RS25770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DN399_RS25780	COG1215	transferase activity, transferring glycosyl groups
DN399_RS25785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DN399_RS25795	COG1388	LysM domain
DN399_RS25795	COG3584	3D domain protein
DN399_RS25825	COG4715	Zinc finger, swim domain protein
DN399_RS25830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN399_RS25870	COG0577	efflux transmembrane transporter activity
DN399_RS25875	COG1136	(ABC) transporter
DN399_RS25895	COG2271	Major facilitator Superfamily
DN399_RS25910	COG5002	protein histidine kinase activity
DN399_RS25915	COG0745	RESPONSE REGULATOR receiver
DN399_RS25925	COG1316	TRANSCRIPTIONal
DN399_RS25935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DN399_RS25940	COG1215	transferase activity, transferring glycosyl groups
DN399_RS25960	COG0438	transferase activity, transferring glycosyl groups
DN399_RS25965	COG0438	transferase activity, transferring glycosyl groups
DN399_RS25980	COG1086	Polysaccharide biosynthesis protein
DN399_RS25990	COG1045	serine acetyltransferase
DN399_RS25995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DN399_RS26000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DN399_RS26005	COG1086	Polysaccharide biosynthesis protein
DN399_RS26010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DN399_RS26015	COG4464	protein tyrosine phosphatase activity
DN399_RS26020	COG0489	protein tyrosine kinase activity
DN399_RS26025	COG3944	biosynthesis protein
DN399_RS26030	COG0489	protein tyrosine kinase activity
DN399_RS26045	COG1609	Transcriptional regulator
DN399_RS26055	COG0739	heme binding
DN399_RS26070	COG3279	Response regulator of the LytR AlgR family
DN399_RS26075	COG2385	sporulation resulting in formation of a cellular spore
DN399_RS26090	COG4836	Membrane
DN399_RS26095	COG1007	ATP synthesis coupled electron transport
DN399_RS26100	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN399_RS26105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DN399_RS26115	COG0839	Belongs to the complex I subunit 6 family
DN399_RS26135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DN399_RS26150	COG3300	MHYT domain
DN399_RS26150	COG5001	Diguanylate cyclase
DN399_RS26200	COG0356	it plays a direct role in the translocation of protons across the membrane
DN399_RS26235	COG0698	ribose 5-phosphate isomerase
DN399_RS26250	COG2259	Doxx family
DN399_RS26255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DN399_RS26270	COG0009	L-threonylcarbamoyladenylate synthase
DN399_RS26310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DN399_RS26315	COG1494	fructose-1,6-bisphosphatase
DN399_RS26335	COG4821	SIS domain
DN399_RS26345	COG3343	RNA polymerase activity
DN399_RS26355	COG1960	acyl-CoA dehydrogenase activity
DN399_RS26360	COG1960	acyl-CoA dehydrogenase activity
DN399_RS26365	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN399_RS26370	COG0183	Belongs to the thiolase family
DN399_RS26375	COG0247	lactate metabolic process
DN399_RS26375	COG2181	nitrate reductase activity
DN399_RS26380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DN399_RS26390	COG5001	Diguanylate cyclase
DN399_RS26390	COG3300	MHYT domain
DN399_RS26405	COG3227	Zinc metalloprotease (Elastase)
DN399_RS26410	COG2197	response regulator
DN399_RS26415	COG4585	Histidine kinase
DN399_RS26420	COG0842	Transport permease protein
DN399_RS26425	COG1131	(ABC) transporter
DN399_RS26430	COG0024	Methionine aminopeptidase
DN399_RS26440	COG2234	aminopeptidase activity
DN399_RS26465	COG4506	Protein conserved in bacteria
DN399_RS26470	COG1619	proteins homologs of microcin C7 resistance protein MccF
DN399_RS26495	COG2814	Major facilitator Superfamily
DN399_RS26500	COG0789	Transcriptional regulator
DN399_RS26505	COG0584	glycerophosphoryl diester phosphodiesterase
DN399_RS26510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN399_RS26520	COG1994	Peptidase M50
DN399_RS26530	COG1078	dGTPase activity
DN399_RS26535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DN399_RS26540	COG1120	ATPase activity
DN399_RS26545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS26550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DN399_RS26570	COG0280	phosphate acetyltransferase
DN399_RS26585	COG3773	Cell wall hydrolase
DN399_RS26595	COG2363	Small membrane protein
DN399_RS26605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DN399_RS26610	COG2233	PERMEase
DN399_RS26615	COG0561	phosphatase activity
DN399_RS26620	COG2814	Major facilitator Superfamily
DN399_RS26630	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DN399_RS26635	COG1131	(ABC) transporter
DN399_RS26640	COG2755	lipolytic protein G-D-S-L family
DN399_RS26645	COG1609	Transcriptional regulator
DN399_RS26655	COG0460	homoserine dehydrogenase
DN399_RS26665	COG2873	o-acetylhomoserine
DN399_RS26675	COG1011	Hydrolase
DN399_RS26680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DN399_RS26690	COG2197	response regulator
DN399_RS26695	COG2203	Gaf domain
DN399_RS26695	COG4585	Histidine kinase
DN399_RS26700	COG0351	phosphomethylpyrimidine kinase
DN399_RS26705	COG3706	GGDEF domain
DN399_RS26710	COG2879	small protein
DN399_RS26715	COG1966	Carbon starvation protein
DN399_RS26720	COG3279	Response regulator of the LytR AlgR family
DN399_RS26725	COG0477	Major facilitator Superfamily
DN399_RS26740	COG0438	transferase activity, transferring glycosyl groups
DN399_RS26755	COG0840	transmembrane signaling receptor activity
DN399_RS26765	COG1607	acyl-coa hydrolase
DN399_RS26775	COG1216	Glycosyl transferase, family 2
DN399_RS26790	COG0463	Glycosyl transferase, family 2
DN399_RS26795	COG0488	(ABC) transporter
DN399_RS26800	COG1309	transcriptional regulator
DN399_RS26805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DN399_RS26810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN399_RS26810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DN399_RS26815	COG0628	permease
DN399_RS26835	COG3275	phosphorelay sensor kinase activity
DN399_RS26840	COG2814	Major facilitator Superfamily
DN399_RS26845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DN399_RS26850	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DN399_RS26880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DN399_RS26885	COG1272	protein, Hemolysin III
DN399_RS26905	COG1164	Oligoendopeptidase f
DN399_RS26915	COG5002	protein histidine kinase activity
DN399_RS26930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN399_RS26935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DN399_RS26940	COG4853	Protein conserved in bacteria
DN399_RS26950	COG5002	protein histidine kinase activity
DN399_RS26955	COG0745	RESPONSE REGULATOR receiver
DN399_RS26985	COG0305	Participates in initiation and elongation during chromosome replication
DN399_RS26995	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DN399_RS27000	COG4241	membrane
DN399_RS27020	COG0012	GTP binding
DN399_RS27025	COG4481	Protein conserved in bacteria
DN399_RS27030	COG0668	transmembrane transport
DN399_RS27040	COG1475	DNA binding
DN399_RS27045	COG1192	Involved in chromosome partitioning
DN399_RS27070	COG1847	R3H domain protein
DN399_RS27085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DN399_RS27120	COG0457	Tetratricopeptide repeat
DN399_RS27305	COG0791	NLP P60 protein
DN399_RS27305	COG0741	lytic transglycosylase activity
DN399_RS27375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN399_RS27375	COG0551	DNA topoisomerase type I activity
DN399_RS27405	COG1104	cysteine desulfurase activity
DN399_RS27425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DN399_RS27460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN399_RS27515	COG0653	protein targeting
DN399_RS27530	COG4166	transmembrane transport
DN399_RS27560	COG3103	Sh3 type 3 domain protein
DN399_RS27560	COG1388	LysM domain
DN399_RS27560	COG0791	NLP P60 protein
DN399_RS27570	COG1522	sequence-specific DNA binding
DN399_RS27575	COG5632	N-Acetylmuramoyl-L-alanine amidase
DN399_RS27575	COG3409	Peptidoglycan-binding domain 1 protein
DN399_RS27590	COG0456	acetyltransferase
DN399_RS27720	COG1760	l-serine dehydratase
DN399_RS27730	COG0156	8-amino-7-oxononanoate synthase activity
DN399_RS27855	COG0791	NLP P60 protein
DN399_RS27855	COG0741	lytic transglycosylase activity
DN399_RS27885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DN399_RS27885	COG0551	DNA topoisomerase type I activity
DN399_RS27895	COG5002	protein histidine kinase activity
DN399_RS27925	COG1192	Involved in chromosome partitioning