locus-tag class description FJM75_RS00015 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FJM75_RS00020 ENOG4108ZCF integral membrane protein FJM75_RS00035 ENOG4105DPN Oligoendopeptidase f FJM75_RS00045 ENOG4105T58 Dithiol-disulfide isomerase FJM75_RS00050 ENOG4108Z18 K06886 hemoglobin FJM75_RS00055 ENOG4105MIX Adenylate cyclase FJM75_RS00075 ENOG4105EMS pseudouridine synthase FJM75_RS00080 ENOG4107S1Q Phosphatase FJM75_RS00090 ENOG4105CJW magnesium transporter FJM75_RS00105 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FJM75_RS00110 ENOG4108KS4 Spore coat protein FJM75_RS00115 ENOG4107SBE Glycosyl transferase (Group 1 FJM75_RS00135 ENOG4107SBE Glycosyl transferase (Group 1 FJM75_RS00140 ENOG4108IAJ Nad-dependent epimerase dehydratase FJM75_RS00165 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) FJM75_RS00170 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FJM75_RS00175 ENOG4105C5E polysaccharide biosynthesis protein FJM75_RS00190 ENOG4105K64 Glycosyl transferase, family 2 FJM75_RS00205 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FJM75_RS00210 ENOG4105C1B dTDP-glucose 4-6-dehydratase FJM75_RS00215 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FJM75_RS00220 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase FJM75_RS00310 ENOG4107TVC Glycosyl transferase, family 2 FJM75_RS00315 ENOG4105H67 Protein of unknown function (DUF421) FJM75_RS00325 ENOG4108ZMI UPF0477 protein FJM75_RS00335 ENOG4108W5N phosphatidylglycerophosphatase a FJM75_RS00355 ENOG41073R8 VanW family FJM75_RS00360 ENOG4105BZU Histidine kinase FJM75_RS00380 ENOG4105D7N magnesium and cobalt transport protein CorA FJM75_RS00385 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FJM75_RS00395 ENOG4105C0R drug resistance transporter emrb qaca subfamily FJM75_RS00405 ENOG4105EJ9 Membrane FJM75_RS00415 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FJM75_RS00420 ENOG4105CH2 amidohydrolase FJM75_RS00425 ENOG4106AUC UPF0180 protein FJM75_RS00430 ENOG4105WS7 Cation transport regulator FJM75_RS00435 ENOG4105D8X mechanosensitive ion channel FJM75_RS00440 ENOG4105D3R alkyl hydroperoxide reductase FJM75_RS00445 ENOG4105BZ1 (ABC) transporter FJM75_RS00450 ENOG4105BZ1 (ABC) transporter FJM75_RS00465 ENOG4107ZYR domain protein FJM75_RS00470 ENOG4105CN5 Metallo-Beta-Lactamase FJM75_RS00475 ENOG4106148 UPF0356 protein FJM75_RS00480 ENOG4108Q5Y Membrane FJM75_RS00485 ENOG4108X4Q Hydrolase FJM75_RS00490 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FJM75_RS00505 ENOG4105CPP Dehydrogenase, E1 component FJM75_RS00510 ENOG4105C7S Dehydrogenase FJM75_RS00520 ENOG4105C94 Transporter FJM75_RS00540 ENOG4105CXN decarboxylase FJM75_RS00545 ENOG4105EA8 2-Nitropropane dioxygenase FJM75_RS00550 ENOG4105WBI UPF0223 protein FJM75_RS00555 ENOG4108WQ8 UPF0637 protein FJM75_RS00565 ENOG4105ECY inositol monophosphatase FJM75_RS00580 ENOG4105CI3 gtp-binding protein typa FJM75_RS00585 ENOG4105QA2 FJM75_RS00615 ENOG4108IAB Phoh family FJM75_RS00625 ENOG4105CSV Glutaminase FJM75_RS00630 ENOG4105ZPI UPF0358 protein FJM75_RS00640 ENOG4105CNI cell division protein FtsW FJM75_RS00645 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FJM75_RS00655 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FJM75_RS00660 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FJM75_RS00665 ENOG4105BZ9 Cytochrome C oxidase, subunit I FJM75_RS00670 ENOG4105CCU oxidase (Subunit III) FJM75_RS00675 ENOG41064X9 cytochrome C oxidase subunit IV FJM75_RS00680 ENOG4108REF Sporulation integral membrane protein ytvi FJM75_RS00690 ENOG4105K4I Scp-like extracellular FJM75_RS00700 ENOG4106UY4 Inherit from COG: Scp-like extracellular FJM75_RS00740 ENOG4105WUC UPF0298 protein FJM75_RS00760 ENOG4106H78 methyltransferase FJM75_RS00765 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FJM75_RS00770 ENOG4105H20 Sporulation integral membrane protein YlbJ FJM75_RS00775 ENOG4105D78 K07001 NTE family protein FJM75_RS00780 ENOG41063PX domain protein FJM75_RS00785 ENOG4105CDE UPF0348 protein FJM75_RS00790 ENOG4105KNH Nucleic acid-binding protein FJM75_RS00795 ENOG41067VY 50S ribosomal protein L32 FJM75_RS00800 ENOG4105E39 Enoyl-CoA hydratase FJM75_RS00810 ENOG4108YG3 N-acetyltransferase FJM75_RS00815 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FJM75_RS00820 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FJM75_RS00825 ENOG4107QX3 carboxylase FJM75_RS00830 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FJM75_RS00840 ENOG41074B2 UPF0747 protein FJM75_RS00845 ENOG4108V6E Cell division protein mraZ FJM75_RS00850 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FJM75_RS00860 ENOG4105CJN penicillin-binding protein FJM75_RS00865 ENOG4105CJN penicillin-binding protein FJM75_RS00870 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FJM75_RS00875 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FJM75_RS00880 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FJM75_RS00885 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FJM75_RS00890 ENOG4105CNI cell division protein FtsW FJM75_RS00895 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FJM75_RS00900 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FJM75_RS00905 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FJM75_RS00910 ENOG4105D6E homoserine dehydrogenase FJM75_RS00915 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FJM75_RS00920 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FJM75_RS00925 ENOG4108AWX Sporulation factor SpoIIGA FJM75_RS00930 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FJM75_RS00940 ENOG4105WR5 sporulation protein, YlmC YmxH family FJM75_RS00945 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FJM75_RS00950 ENOG4105DFA alanine racemase domain protein FJM75_RS00955 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FJM75_RS00965 ENOG4105DBK s4 domain protein FJM75_RS00980 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FJM75_RS00985 ENOG4105C34 Pseudouridine synthase FJM75_RS00990 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FJM75_RS01000 ENOG4105CXT aspartate transcarbamylase FJM75_RS01005 ENOG4105CD3 dihydroorotase FJM75_RS01015 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FJM75_RS01025 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FJM75_RS01030 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FJM75_RS01040 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FJM75_RS01045 ENOG4107SJB teichoic acid biosynthesis FJM75_RS01060 ENOG4105DSJ YicC domain protein FJM75_RS01065 ENOG4105KC4 UPF0296 protein FJM75_RS01070 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FJM75_RS01080 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FJM75_RS01085 ENOG4105C25 Primosomal protein n' FJM75_RS01095 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FJM75_RS01100 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FJM75_RS01115 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FJM75_RS01120 ENOG4105DJV ribulose-phosphate 3-epimerase FJM75_RS01125 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FJM75_RS01130 ENOG4105FJ0 thiamine FJM75_RS01140 ENOG4105VB9 50S ribosomal protein l28 FJM75_RS01145 ENOG4108ZAA Alkaline-shock protein FJM75_RS01150 ENOG4105DP4 dak2 domain fusion protein ylov FJM75_RS01160 ENOG4105EJQ L-serine dehydratase FJM75_RS01165 ENOG4105CB5 ATP-dependent DNA helicase recG FJM75_RS01170 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FJM75_RS01175 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FJM75_RS01180 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FJM75_RS01185 ENOG4105CHR reductase FJM75_RS01190 ENOG410854A Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FJM75_RS01205 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FJM75_RS01210 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FJM75_RS01215 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) FJM75_RS01225 ENOG4105K5M 30s ribosomal protein S16 FJM75_RS01230 ENOG4108BW8 UPF0109 protein FJM75_RS01250 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FJM75_RS01260 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FJM75_RS01265 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FJM75_RS01275 ENOG4105CMV Succinyl-CoA synthetase subunit beta FJM75_RS01280 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FJM75_RS01285 ENOG4105C79 DNA protecting protein DprA FJM75_RS01290 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FJM75_RS01295 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FJM75_RS01300 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FJM75_RS01305 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FJM75_RS01310 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FJM75_RS01315 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) FJM75_RS01320 ENOG4105CE9 30S ribosomal protein S2 FJM75_RS01325 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FJM75_RS01330 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FJM75_RS01335 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FJM75_RS01340 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FJM75_RS01345 ENOG4105KNE Phosphatidate cytidylyltransferase FJM75_RS01350 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FJM75_RS01355 ENOG4105DZP Membrane-associated zinc metalloprotease FJM75_RS01365 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FJM75_RS01370 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FJM75_RS01375 ENOG4105CHV Transcription elongation factor NusA FJM75_RS01380 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FJM75_RS01385 ENOG4105VHM ribosomal protein FJM75_RS01390 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FJM75_RS01395 ENOG4105W7A Protein of unknown function (DUF503) FJM75_RS01400 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FJM75_RS01405 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FJM75_RS01410 ENOG4105DTN riboflavin biosynthesis protein ribF FJM75_RS01415 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FJM75_RS01420 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FJM75_RS01430 ENOG4105C1V Peptidase, M16 FJM75_RS01440 ENOG4105E35 Dipicolinate synthase subunit A FJM75_RS01445 ENOG4108S0H Dipicolinic acid synthetase, b subunit FJM75_RS01450 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FJM75_RS01460 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FJM75_RS01465 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FJM75_RS01475 ENOG4105CNU cell division protein FtsK FJM75_RS01480 ENOG4105DIH basic membrane FJM75_RS01485 ENOG4108JQ9 ABC transporter FJM75_RS01490 ENOG4105UIB (ABC) transporter FJM75_RS01510 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FJM75_RS01515 ENOG4105XZV Protein of unknown function (DUF3243) FJM75_RS01530 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FJM75_RS01535 ENOG4105CEV competence damage-inducible protein FJM75_RS01540 ENOG4105C1J atp-dependent rna helicase FJM75_RS01545 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FJM75_RS01555 ENOG4105D48 metallophosphoesterase FJM75_RS01560 ENOG4105MCT stage V sporulation protein S FJM75_RS01565 ENOG4108IGT Dipeptidase FJM75_RS01570 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FJM75_RS01575 ENOG4105DQU oxidoreductase, subunit beta FJM75_RS01580 ENOG4105CPQ Dehydrogenase FJM75_RS01585 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FJM75_RS01590 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FJM75_RS01620 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FJM75_RS01625 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FJM75_RS01650 ENOG4106F1P AAA ATPase, central domain protein FJM75_RS01655 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FJM75_RS01660 ENOG4105CXI aluminum resistance protein FJM75_RS01665 ENOG4105C5F glutamine synthetase FJM75_RS01670 ENOG410682Q Phage transcriptional regulator, ArpU FJM75_RS01690 ENOG4105CFI type iii restriction protein res subunit FJM75_RS01695 ENOG4105C4R Atp-dependent dna helicase FJM75_RS01735 ENOG4105NAE bifunctional deaminase-reductase domain protein FJM75_RS01755 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FJM75_RS01775 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FJM75_RS01780 ENOG41067Z0 domain protein FJM75_RS01785 ENOG4108SVB resolvase FJM75_RS01790 ENOG4105VPS UPF0291 protein FJM75_RS01805 ENOG4105VXM UPF0154 protein FJM75_RS01810 ENOG4108VXD carboxy-peptidase FJM75_RS01815 ENOG4107QIV Cytochrome c biogenesis protein FJM75_RS01820 ENOG4105HC0 Na H antiporter FJM75_RS01840 ENOG4105EM7 Selenocysteine-specific translation elongation factor FJM75_RS01855 ENOG4105D5T phosphonate abc transporter FJM75_RS01870 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FJM75_RS01885 ENOG410746C Acid-soluble spore protein O FJM75_RS01890 ENOG4108I0Z Aconitate hydratase FJM75_RS01915 ENOG41067CD Small, acid-soluble spore protein Tlp FJM75_RS01925 ENOG4105MI2 FJM75_RS01930 ENOG4105W8X HesB YadR YfhF-family protein FJM75_RS01935 ENOG41090WU lipolytic protein G-D-S-L family FJM75_RS01940 ENOG41090WU lipolytic protein G-D-S-L family FJM75_RS01960 ENOG4105CHR reductase FJM75_RS01975 ENOG4105C1J atp-dependent rna helicase FJM75_RS01980 ENOG410890F Dynamin family FJM75_RS01990 ENOG4105CHM Aminotransferase FJM75_RS01995 ENOG4108K8K Transcriptional regulator FJM75_RS02000 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FJM75_RS02015 ENOG4107S4Y M20 DapE family protein YgeY FJM75_RS02020 ENOG4108TSC N-acetyltransferase FJM75_RS02025 ENOG4108JUB Transcriptional regulator FJM75_RS02030 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FJM75_RS02050 ENOG41081VK Ribonuclease FJM75_RS02070 ENOG4105VEQ Cold shock protein FJM75_RS02080 ENOG4108S4H thioesterase Superfamily protein FJM75_RS02090 ENOG4105QNR S1 RNA binding domain protein FJM75_RS02105 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FJM75_RS02110 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FJM75_RS02120 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FJM75_RS02125 ENOG4105BZU Histidine kinase FJM75_RS02130 ENOG4108REF Sporulation integral membrane protein ytvi FJM75_RS02145 ENOG4108Y6J UPF0403 protein FJM75_RS02155 ENOG4105C72 UPF0176 protein FJM75_RS02175 ENOG4105FDT acyl-CoA dehydrogenase FJM75_RS02180 ENOG4105F0V Cell wall hydrolase FJM75_RS02185 ENOG4105Y38 Kinase-associated protein B FJM75_RS02190 ENOG4105C72 UPF0176 protein FJM75_RS02260 ENOG4105ZKE UPF0349 protein FJM75_RS02265 ENOG4105C3M thioredoxin reductase FJM75_RS02275 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FJM75_RS02280 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FJM75_RS02285 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FJM75_RS02305 ENOG4105C5H ABC transporter FJM75_RS02310 ENOG4108ME1 Peptidase M55 D-aminopeptidase FJM75_RS02315 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FJM75_RS02320 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FJM75_RS02330 ENOG4105DTQ mandelate racemase muconate lactonizing FJM75_RS02335 ENOG4107SN7 NLP P60 protein FJM75_RS02345 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FJM75_RS02385 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FJM75_RS02400 ENOG4105VMP Transcriptional regulator FJM75_RS02405 ENOG4105NX3 Membrane FJM75_RS02450 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FJM75_RS02455 ENOG4107S6Z Na H antiporter FJM75_RS02460 ENOG4107YV3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FJM75_RS02470 ENOG4108JJ9 ABC, transporter FJM75_RS02475 ENOG4108JJ8 (ABC) transporter FJM75_RS02500 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FJM75_RS02505 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FJM75_RS02510 ENOG4105CAS nag kinase FJM75_RS02515 ENOG4105C8Y Acetylornithine aminotransferase FJM75_RS02520 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FJM75_RS02530 ENOG4105DBV ornithine carbamoyltransferase FJM75_RS02535 ENOG4105CDH Citrulline--aspartate ligase FJM75_RS02540 ENOG4105CH7 arginosuccinase FJM75_RS02550 ENOG4108NRW Phospholipase, patatin family FJM75_RS02555 ENOG4105C26 Dehydrogenase FJM75_RS02560 ENOG4105C88 aminopeptidase FJM75_RS02580 ENOG4105XJB lipolytic protein G-D-S-L family FJM75_RS02585 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process FJM75_RS02590 ENOG4105SZ6 Thioredoxin FJM75_RS02605 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FJM75_RS02615 ENOG4105C0R drug resistance transporter emrb qaca subfamily FJM75_RS02620 ENOG4105C5Q Transcriptional regulator FJM75_RS02625 ENOG4105CBC glutamate synthase FJM75_RS02630 ENOG4105BZ8 glutamate synthase FJM75_RS02635 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FJM75_RS02640 ENOG4105FBA Phospholipase Carboxylesterase FJM75_RS02650 ENOG4107YX5 Pfam:DUF548 FJM75_RS02655 ENOG4108VCA G U mismatch-specific DNA glycosylase FJM75_RS02670 ENOG4107T89 von Willebrand factor, type A FJM75_RS02675 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FJM75_RS02685 ENOG4108TN2 lmbE family FJM75_RS02690 ENOG4105C5H ABC transporter FJM75_RS02695 ENOG4107QMU Mate efflux family protein FJM75_RS02700 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FJM75_RS02705 ENOG4108M15 ABC transporter FJM75_RS02715 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FJM75_RS02730 ENOG4107SJI Dehydrogenase FJM75_RS02760 ENOG4105C26 Dehydrogenase FJM75_RS02765 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FJM75_RS02770 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FJM75_RS02775 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FJM75_RS02780 ENOG4105C7S Dehydrogenase FJM75_RS02790 ENOG4105CUC YeeE YedE family protein FJM75_RS02800 ENOG41061CK Antibiotic biosynthesis monooxygenase FJM75_RS02845 ENOG4105FDT acyl-CoA dehydrogenase FJM75_RS02855 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FJM75_RS02865 ENOG4105HMI Membrane FJM75_RS02885 ENOG4105CZM Major Facilitator FJM75_RS02890 ENOG4105DMF Dehydrogenase FJM75_RS02895 ENOG4107R8B 5'-nucleotidase FJM75_RS02920 ENOG4108MDK Dehydrogenase FJM75_RS02925 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FJM75_RS02930 ENOG4105C7B Threonine dehydratase FJM75_RS02935 ENOG4105DEN Luciferase family FJM75_RS02940 ENOG4105DVT helicase FJM75_RS02950 ENOG4105CVJ phosphoglycerate mutase FJM75_RS02965 ENOG4107ZYR domain protein FJM75_RS02970 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FJM75_RS02975 ENOG4105K4I Scp-like extracellular FJM75_RS02980 ENOG4105C1G acyl-Coa dehydrogenase FJM75_RS02995 ENOG4105DZ6 Band 7 protein FJM75_RS03000 ENOG4105CQB FAD linked oxidase domain protein FJM75_RS03005 ENOG4108JUB Transcriptional regulator FJM75_RS03015 ENOG4105C1G acyl-Coa dehydrogenase FJM75_RS03030 ENOG4105CEY Amp-dependent synthetase and ligase FJM75_RS03035 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FJM75_RS03040 ENOG4105E39 Enoyl-CoA hydratase FJM75_RS03050 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FJM75_RS03080 ENOG4105DY8 decarboxylase FJM75_RS03115 ENOG4107SET aldo keto reductase FJM75_RS03130 ENOG4105CMU LysR family (Transcriptional regulator FJM75_RS03135 ENOG4105C82 Malate synthase FJM75_RS03140 ENOG4105JXH GntR family transcriptional regulator FJM75_RS03145 ENOG4105CQB FAD linked oxidase domain protein FJM75_RS03150 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FJM75_RS03155 ENOG4105CQB FAD linked oxidase domain protein FJM75_RS03165 ENOG4105DAA L-lactate FJM75_RS03170 ENOG4105C2W permease FJM75_RS03175 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FJM75_RS03180 ENOG4105DEN Luciferase family FJM75_RS03190 ENOG4105DAA L-lactate FJM75_RS03205 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FJM75_RS03225 ENOG4105D4A Cell wall formation (By similarity) FJM75_RS03230 ENOG41090UD (LipO)protein FJM75_RS03240 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding FJM75_RS03245 ENOG4105BZU Histidine kinase FJM75_RS03250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FJM75_RS03270 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FJM75_RS03280 ENOG4105DWD nucleoside recognition domain protein FJM75_RS03295 ENOG4105DTQ mandelate racemase muconate lactonizing FJM75_RS03325 ENOG4105C87 Aminotransferase class I and II FJM75_RS03340 ENOG4107K5X Membrane-bound metal-dependent hydrolase FJM75_RS03350 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FJM75_RS03375 ENOG4105DUX Transporter FJM75_RS03385 ENOG4105JZI cytochrome P450 FJM75_RS03400 ENOG4105K4P CoA-binding domain protein FJM75_RS03405 ENOG4105F22 Major Facilitator Superfamily FJM75_RS03410 ENOG4105VEQ Cold shock protein FJM75_RS03420 ENOG4105DWD nucleoside recognition domain protein FJM75_RS03425 ENOG4105CIS alcohol dehydrogenase FJM75_RS03445 ENOG4105CEY Amp-dependent synthetase and ligase FJM75_RS03455 ENOG4108IV0 ABC, transporter FJM75_RS03460 ENOG4105C0Z ABC transporter FJM75_RS03465 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FJM75_RS03470 ENOG4105C32 Amino acid ABC transporter (Permease) FJM75_RS03475 ENOG4105CGU Enoyl-CoA hydratase FJM75_RS03485 ENOG4105C1G acyl-Coa dehydrogenase FJM75_RS03505 ENOG4105E39 Enoyl-CoA hydratase FJM75_RS03510 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FJM75_RS03515 ENOG4108RZE Tetr family transcriptional regulator FJM75_RS03520 ENOG4105CEY Amp-dependent synthetase and ligase FJM75_RS03525 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FJM75_RS03530 ENOG4105CHU acetyl-coa acetyltransferase FJM75_RS03535 ENOG4105CHR reductase FJM75_RS03540 ENOG4105C1G acyl-Coa dehydrogenase FJM75_RS03545 ENOG4105D8K carboxyl transferase FJM75_RS03550 ENOG4105CEY Amp-dependent synthetase and ligase FJM75_RS03555 ENOG4105CTD carboxy-peptidase FJM75_RS03575 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FJM75_RS03585 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FJM75_RS03590 ENOG4106F55 Protein of unknown function (DUF1273) FJM75_RS03610 ENOG4107X2U Inherit from COG: Exonuclease-like protein FJM75_RS03615 ENOG4108I5C dEAD DEAH box helicase FJM75_RS03625 ENOG4105C7Z Conserved Protein FJM75_RS03640 ENOG4105C84 Histidine ammonia-lyase FJM75_RS03645 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) FJM75_RS03650 ENOG4108903 Formimidoylglutamase FJM75_RS03655 ENOG4105CI2 imidazolone-5-propionate hydrolase FJM75_RS03660 ENOG4105CGP Urocanate hydratase FJM75_RS03665 ENOG4105WYW fructose-bisphosphate aldolase FJM75_RS03670 ENOG4106R3P AraC family transcriptional regulator FJM75_RS03690 ENOG4105CUJ penicillin amidase FJM75_RS03695 ENOG4105CM2 brancheD-chain amino acid aminotransferase FJM75_RS03730 ENOG4108HKT sucrose-6-phosphate hydrolase FJM75_RS03735 ENOG4105C5Y PTS System FJM75_RS03740 ENOG4105ETE Transcriptional regulator (LacI family FJM75_RS03785 ENOG4105KNA -acetyltransferase FJM75_RS03790 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FJM75_RS03800 ENOG4108V4B ThiJ pfpI FJM75_RS03825 ENOG4105DBI uridine monophosphokinase FJM75_RS03915 ENOG4108MK9 spermidine N(1)-acetyltransferase FJM75_RS03920 ENOG4105CNI cell division protein FtsW FJM75_RS03945 ENOG4105KNA -acetyltransferase FJM75_RS03970 ENOG41086D8 Transcriptional regulator FJM75_RS03975 ENOG4105CVJ phosphoglycerate mutase FJM75_RS04000 ENOG4105CVJ phosphoglycerate mutase FJM75_RS04015 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FJM75_RS04025 ENOG4107VFR oxidoreductase FJM75_RS04035 ENOG4105EN6 Membrane FJM75_RS04040 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FJM75_RS04050 ENOG4108R1P FJM75_RS04070 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 FJM75_RS04075 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FJM75_RS04115 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FJM75_RS04140 ENOG4106210 phosphatase activity FJM75_RS04145 ENOG4105C3M thioredoxin reductase FJM75_RS04150 ENOG4105DZ1 carboxypeptidase FJM75_RS04185 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FJM75_RS04190 ENOG4105BZ4 penicillin-binding protein FJM75_RS04195 ENOG4105CSM endonuclease III FJM75_RS04205 ENOG4105C5S asparaginyl-tRNA synthetase FJM75_RS04210 ENOG4105CHM Aminotransferase FJM75_RS04220 ENOG4105YAC FJM75_RS04230 ENOG4105DVT helicase FJM75_RS04235 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FJM75_RS04240 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FJM75_RS04255 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FJM75_RS04260 ENOG4105CPK Glycosyl transferase (Group 1 FJM75_RS04265 ENOG4105FJR Lmbe family FJM75_RS04270 ENOG4108Z5K methylglyoxal synthase FJM75_RS04275 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FJM75_RS04280 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FJM75_RS04285 ENOG4108JYZ YitT family FJM75_RS04305 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FJM75_RS04310 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FJM75_RS04315 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FJM75_RS04335 ENOG41068YB TPR repeat-containing protein FJM75_RS04340 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FJM75_RS04350 ENOG4105CIH Imidazole acetol-phosphate transaminase FJM75_RS04355 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FJM75_RS04360 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FJM75_RS04365 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FJM75_RS04370 ENOG4105DK0 Indole-3-glycerol phosphate synthase FJM75_RS04375 ENOG4108I0Q anthranilate phosphoribosyltransferase FJM75_RS04385 ENOG4105KHN chorismate mutase FJM75_RS04390 ENOG4105D49 3-dehydroquinate synthase FJM75_RS04395 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FJM75_RS04400 ENOG4105DV0 amidase (EC 3.5.1.4 FJM75_RS04405 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FJM75_RS04410 ENOG4105EAH synthase FJM75_RS04420 ENOG4105XXQ heptaprenyl diphosphate synthase component I FJM75_RS04425 ENOG4105WP2 Tryptophan RNA-binding attenuator protein FJM75_RS04430 ENOG4105EUJ GTP cyclohydrolase i FJM75_RS04435 ENOG4105K70 DNA-binding protein FJM75_RS04440 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FJM75_RS04465 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FJM75_RS04470 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FJM75_RS04475 ENOG41065D1 FJM75_RS04480 ENOG4105S2F FJM75_RS04495 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FJM75_RS04500 ENOG4105F6E Acyl-transferase FJM75_RS04505 ENOG4105CAT Cytidine monophosphate kinase FJM75_RS04515 ENOG4105MSI germination protein ypeb FJM75_RS04525 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) FJM75_RS04530 ENOG4107RB3 L-asparaginase FJM75_RS04535 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FJM75_RS04545 ENOG4105CPF Cell wall formation (By similarity) FJM75_RS04550 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FJM75_RS04555 ENOG4108S6Z Negative regulator of genetic competence FJM75_RS04560 ENOG4107X2D transcriptional regulator, merr family FJM75_RS04565 ENOG4107RGJ metallophosphoesterase FJM75_RS04595 ENOG4105C9U ATP-dependent DNA helicase RecQ FJM75_RS04600 ENOG4105T7X FJM75_RS04610 ENOG4108JQ1 Dehydrogenase FJM75_RS04615 ENOG4107RVV histidinol phosphate phosphatase, hisj family FJM75_RS04620 ENOG4105BZU Histidine kinase FJM75_RS04625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FJM75_RS04630 ENOG4105CRE cytochrome C FJM75_RS04635 ENOG4107TWT Cytochrome c biogenesis protein FJM75_RS04640 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FJM75_RS04645 ENOG4105FE9 pseudouridine synthase FJM75_RS04655 ENOG4108JIC nucleoside recognition domain protein FJM75_RS04660 ENOG4105DZ1 carboxypeptidase FJM75_RS04670 ENOG41065KQ synthase FJM75_RS04680 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FJM75_RS04700 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FJM75_RS04705 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FJM75_RS04710 ENOG4108R6K riboflavin synthase, subunit alpha FJM75_RS04715 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FJM75_RS04720 ENOG4107ZE5 PPIases accelerate the folding of proteins FJM75_RS04725 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FJM75_RS04735 ENOG4105G6R Stage v sporulation protein ae FJM75_RS04745 ENOG4105CZ3 stage V sporulation protein ad FJM75_RS04750 ENOG41090VF Stage v sporulation protein ac FJM75_RS04765 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FJM75_RS04770 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FJM75_RS04775 ENOG41082AN stage II sporulation protein FJM75_RS04780 ENOG4105DZ1 carboxypeptidase FJM75_RS04800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FJM75_RS04810 ENOG4105I3K Ferric uptake regulator, Fur family FJM75_RS04815 ENOG4105MZ9 stage II sporulation protein m FJM75_RS04825 ENOG4108YZ4 nudix hydrolase FJM75_RS04840 ENOG4105CPC Aldo Keto reductase FJM75_RS04845 ENOG4108IIH CoA-transferase subunit B FJM75_RS04850 ENOG4105D6N CoA-transferase, subunit a FJM75_RS04855 ENOG4105CHU acetyl-coa acetyltransferase FJM75_RS04860 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FJM75_RS04870 ENOG4106HZJ FJM75_RS04890 ENOG4107QN2 dihydrolipoyl dehydrogenase FJM75_RS04905 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FJM75_RS04920 ENOG4105VNH ABC transporter solute-binding protein FJM75_RS04945 ENOG410829K Lysine exporter protein (Lyse ygga) FJM75_RS04950 ENOG4105DTD Dehydrogenase FJM75_RS04955 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FJM75_RS04960 ENOG4105BZ9 Cytochrome C oxidase, subunit I FJM75_RS04965 ENOG4105CCU oxidase (Subunit III) FJM75_RS04980 ENOG4105C94 Transporter FJM75_RS04990 ENOG4108AEY RNA polymerase sigma factor FJM75_RS04995 ENOG4105KZ7 phosphocarrier protein hpr FJM75_RS05000 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FJM75_RS05005 ENOG4108HPI phosphatidate Cytidylyltransferase FJM75_RS05015 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FJM75_RS05025 ENOG4108SUT Major Facilitator Superfamily FJM75_RS05040 ENOG41062A4 Transcriptional regulator FJM75_RS05045 ENOG4105EYF MMPL domain protein FJM75_RS05080 ENOG4105J7I hydrolase FJM75_RS05115 ENOG4105D94 Major Facilitator Superfamily FJM75_RS05120 ENOG4105C8P )-transporter FJM75_RS05135 ENOG4108MUZ hydrolase FJM75_RS05145 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FJM75_RS05165 ENOG4105KAF membrAne FJM75_RS05180 ENOG4108IXY short-chain dehydrogenase reductase FJM75_RS05185 ENOG41069FQ Metallo-beta-lactamase superfamily FJM75_RS05190 ENOG4105II7 pyrroline-5-carboxylate reductase FJM75_RS05200 ENOG4105V75 Transcriptional regulator FJM75_RS05220 ENOG4105C94 Transporter FJM75_RS05225 ENOG4105C8J )-transporter FJM75_RS05235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FJM75_RS05245 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FJM75_RS05265 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FJM75_RS05270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FJM75_RS05275 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FJM75_RS05295 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FJM75_RS05300 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FJM75_RS05310 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FJM75_RS05315 ENOG4108HNZ carboxyl transferase FJM75_RS05320 ENOG4105D5P Methylmalonyl-coA mutase FJM75_RS05325 ENOG4105D5P Methylmalonyl-coA mutase FJM75_RS05335 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FJM75_RS05340 ENOG4108QEG Membrane FJM75_RS05345 ENOG4105CDA abc transporter atp-binding protein FJM75_RS05350 ENOG4105E5Q amino acid AbC transporter FJM75_RS05355 ENOG4108HW3 (ABC) transporter FJM75_RS05360 ENOG4108Y6J UPF0403 protein FJM75_RS05365 ENOG4105C7S Dehydrogenase FJM75_RS05370 ENOG4105CPP Dehydrogenase, E1 component FJM75_RS05390 ENOG4107RDP Dehydrogenase FJM75_RS05400 ENOG4108JUB Transcriptional regulator FJM75_RS05405 ENOG4106CCJ Protein of unknown function (DUF2627) FJM75_RS05410 ENOG4107QQR Sporulation FJM75_RS05415 ENOG4105S1Z Stage IV sporulation protein B FJM75_RS05420 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FJM75_RS05425 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FJM75_RS05430 ENOG4105DX0 Hemolysin A FJM75_RS05435 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FJM75_RS05445 ENOG4105CTB Polyprenyl synthetase FJM75_RS05450 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FJM75_RS05455 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FJM75_RS05460 ENOG4105M7K Involved in the transcription termination process (By similarity) FJM75_RS05465 ENOG4108ZSR alkaline shock protein FJM75_RS05470 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FJM75_RS05490 ENOG410644B Stage III sporulation protein af FJM75_RS05500 ENOG4105KQ4 Stage iii sporulation protein ad FJM75_RS05505 ENOG4108CQH stage III sporulation protein AC FJM75_RS05510 ENOG4105KR5 Stage iii sporulation protein FJM75_RS05515 ENOG4105CD2 stage iii sporulation protein aa FJM75_RS05535 ENOG4105CJ1 ABC, transporter FJM75_RS05540 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FJM75_RS05545 ENOG4105DC7 peptidase M24 FJM75_RS05550 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FJM75_RS05560 ENOG4105CBJ Metal-dependent enzyme FJM75_RS05575 ENOG4105KST dependent repressor FJM75_RS05580 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FJM75_RS05585 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FJM75_RS05590 ENOG4105WZW rhodanese family FJM75_RS05595 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FJM75_RS05600 ENOG4108JEM The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FJM75_RS05610 ENOG4105C0D helicase FJM75_RS05625 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FJM75_RS05650 ENOG4106855 Competence protein FJM75_RS05665 ENOG4107WD4 Releases the N-terminal proline from various substrates (By similarity) FJM75_RS05700 ENOG4105C5X domain protein FJM75_RS05720 ENOG4105C4B ABC transporter, permease FJM75_RS05725 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FJM75_RS05730 ENOG4105DWF phosphomethylpyrimidine kinase FJM75_RS05735 ENOG41080HI glycine oxidase FJM75_RS05740 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FJM75_RS05745 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FJM75_RS05750 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FJM75_RS05760 ENOG4105E0M Sulfatase FJM75_RS05765 ENOG4105DKQ ROK family FJM75_RS05770 ENOG4108DBC nitroreductase FJM75_RS05785 ENOG4105DER m42 family FJM75_RS05805 ENOG4105DFD Na H antiporter FJM75_RS05810 ENOG4105D06 uba thif-type nad fad binding protein FJM75_RS05815 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FJM75_RS05825 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FJM75_RS05830 ENOG4105WDJ 50S ribosomal protein L33 FJM75_RS05840 ENOG4108UTW Plays a role in the regulation of phosphate uptake FJM75_RS05845 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FJM75_RS05850 ENOG4105E2Z phosphate ABC transporter (Permease FJM75_RS05855 ENOG4105C8U phosphate abc transporter FJM75_RS05860 ENOG4105EXS phosphate abc transporter FJM75_RS05865 ENOG4107RF6 penicillin-binding protein FJM75_RS05920 ENOG4105SXS Protein of unknown function (DUF456) FJM75_RS05935 ENOG4105C28 cystathionine FJM75_RS05940 ENOG4105C28 cystathionine FJM75_RS05955 ENOG4108Z73 Siroheme synthase FJM75_RS05960 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FJM75_RS05965 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FJM75_RS05970 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FJM75_RS05975 ENOG4107RIQ Sulfate adenylate transferase FJM75_RS05985 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FJM75_RS06000 ENOG4105PTM secreted protein FJM75_RS06010 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FJM75_RS06015 ENOG41063Y9 FJM75_RS06020 ENOG4108U5J '-nucleotidase FJM75_RS06025 ENOG4105N80 Ferric uptake regulator, Fur family FJM75_RS06030 ENOG4105FAV ABC, transporter FJM75_RS06035 ENOG4105FDK ABC transporter FJM75_RS06040 ENOG4105C9X ppx gppa phosphatase FJM75_RS06045 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FJM75_RS06050 ENOG4107SC1 transglycosylase FJM75_RS06055 ENOG4108JYZ YitT family FJM75_RS06065 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FJM75_RS06080 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FJM75_RS06085 ENOG4105EGD dinuclear metal center protein, YbgI family FJM75_RS06100 ENOG4105CEY Amp-dependent synthetase and ligase FJM75_RS06105 ENOG4105C1G acyl-Coa dehydrogenase FJM75_RS06110 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FJM75_RS06115 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FJM75_RS06120 ENOG4107XJU UPF0178 protein FJM75_RS06125 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FJM75_RS06135 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FJM75_RS06145 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FJM75_RS06150 ENOG4105KG3 cytidine deaminase FJM75_RS06155 ENOG4107YR5 Diacylglycerol kinase FJM75_RS06160 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FJM75_RS06165 ENOG4105CTJ Metal Dependent Phosphohydrolase FJM75_RS06170 ENOG4105C9A Phoh family FJM75_RS06180 ENOG41068P3 sporulation protein YqfC FJM75_RS06190 ENOG4105DI5 UPF0365 protein FJM75_RS06195 ENOG4105F7J membrane-bound serine protease FJM75_RS06200 ENOG4105KTH gatB Yqey FJM75_RS06205 ENOG4105VCC 30S ribosomal protein S21 FJM75_RS06215 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FJM75_RS06220 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FJM75_RS06225 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FJM75_RS06230 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FJM75_RS06235 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FJM75_RS06245 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FJM75_RS06250 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FJM75_RS06255 ENOG4105CSA Coproporphyrinogen iii oxidase FJM75_RS06260 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FJM75_RS06275 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FJM75_RS06280 ENOG4105TQK DNA polymerase iii, delta' subunit FJM75_RS06290 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FJM75_RS06295 ENOG4108UK2 deaminase FJM75_RS06300 ENOG4105KQC Competence protein FJM75_RS06310 ENOG4105DXX methyltransferase FJM75_RS06320 ENOG4108WF2 Metal Dependent Phosphohydrolase FJM75_RS06325 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FJM75_RS06330 ENOG410812S Rna-binding protein FJM75_RS06335 ENOG4105E2X shikimate dehydrogenase FJM75_RS06340 ENOG4105CQW ribosome biogenesis GTPase YqeH FJM75_RS06345 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FJM75_RS06360 ENOG4105D65 subunit l FJM75_RS06365 ENOG4108ZE9 Monovalent cation H antiporter subunit C FJM75_RS06370 ENOG4108JPZ Monovalent cation H antiporter subunit D FJM75_RS06375 ENOG4105SC1 monovalent cation H antiporter subunit E FJM75_RS06385 ENOG4105KJM monovalent cation h antiporter subunit g FJM75_RS06405 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FJM75_RS06415 ENOG4105KPV Transcriptional regulator FJM75_RS06435 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FJM75_RS06465 ENOG4105C28 cystathionine FJM75_RS06475 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FJM75_RS06480 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FJM75_RS06485 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FJM75_RS06500 ENOG4107XRG penicillin-binding protein FJM75_RS06505 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FJM75_RS06510 ENOG4105DBI uridine monophosphokinase FJM75_RS06520 ENOG4105HHA aminodeoxychorismate lyase FJM75_RS06535 ENOG4105VBH UPF0297 protein FJM75_RS06540 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FJM75_RS06545 ENOG4105C02 permease FJM75_RS06550 ENOG41060CR FJM75_RS06555 ENOG4105C7H Helicase, RecD TraA family FJM75_RS06565 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FJM75_RS06570 ENOG4105C3J Cysteine desulfurase FJM75_RS06585 ENOG4105D1H recombination factor protein RarA FJM75_RS06590 ENOG4108VCI transcription factor, rsfa family FJM75_RS06605 ENOG4105CUT histidyl-tRNA synthetase FJM75_RS06615 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FJM75_RS06620 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FJM75_RS06625 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FJM75_RS06630 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FJM75_RS06635 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FJM75_RS06640 ENOG41067VP Protein of unknown function (DUF1049) FJM75_RS06645 ENOG41076HS cation diffusion facilitator family transporter FJM75_RS06665 ENOG4105CKP Polysaccharide Biosynthesis Protein FJM75_RS06670 ENOG4108QG2 Membrane FJM75_RS06680 ENOG4105NAP FJM75_RS06685 ENOG4105VIE preprotein translocase, subunit YajC FJM75_RS06690 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FJM75_RS06695 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FJM75_RS06700 ENOG41061AI Protein of unknown function (DUF2905) FJM75_RS06720 ENOG4105CDY transcriptional regulatory protein FJM75_RS06740 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FJM75_RS06745 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FJM75_RS06750 ENOG4108IYU L-aspartate oxidase FJM75_RS06765 ENOG4105CQC Prephenate dehydratase FJM75_RS06770 ENOG41090I5 UPF0735 ACT domain-containing protein FJM75_RS06775 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FJM75_RS06785 ENOG4105K46 50S ribosomal protein l27 FJM75_RS06790 ENOG4105X36 (ribosomal) protein FJM75_RS06795 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FJM75_RS06800 ENOG4105C03 ribonuclease FJM75_RS06815 ENOG4107QMS site-determining protein FJM75_RS06820 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FJM75_RS06825 ENOG4105YHC Rod shape-determining protein MreD FJM75_RS06830 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FJM75_RS06835 ENOG4105DFF Rod shape-determining protein mreb FJM75_RS06840 ENOG4105W5Q DNA repair protein (RadC FJM75_RS06855 ENOG4106A3R peptidase FJM75_RS06860 ENOG4105BZU Histidine kinase FJM75_RS06865 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FJM75_RS06870 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FJM75_RS06890 ENOG41068KH stage VI sporulation protein D FJM75_RS06890 ENOG41068KH stage VI sporulation protein D FJM75_RS06895 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FJM75_RS06900 ENOG4105D52 delta-aminolevulinic acid dehydratase FJM75_RS06910 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FJM75_RS06920 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FJM75_RS06930 ENOG4105CDA abc transporter atp-binding protein FJM75_RS06935 ENOG4105E5Q amino acid AbC transporter FJM75_RS06940 ENOG4105EAB amino acid AbC transporter FJM75_RS06945 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FJM75_RS06950 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FJM75_RS06955 ENOG4108IUQ atp-dependent protease FJM75_RS06960 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FJM75_RS06965 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FJM75_RS06985 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FJM75_RS06990 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FJM75_RS06995 ENOG4108XJQ germination protein FJM75_RS07005 ENOG41067TZ transcriptional regulator, MarR family FJM75_RS07010 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FJM75_RS07015 ENOG4105KRI phosphocarrier protein (HPr FJM75_RS07025 ENOG4105CID antiterminator FJM75_RS07030 ENOG4105PFC Transcriptional regulator FJM75_RS07035 ENOG4105E33 succinate dehydrogenase FJM75_RS07045 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FJM75_RS07070 ENOG4105EKT )-iron permease FJM75_RS07080 ENOG4105C3Q Glycosyl transferase, family 2 FJM75_RS07105 ENOG4105K63 Thioredoxin FJM75_RS07110 ENOG4105C10 Electron transfer flavoprotein FJM75_RS07115 ENOG4105BZJ Electron transfer flavoprotein FJM75_RS07120 ENOG41060WC Enoyl-CoA hydratase FJM75_RS07125 ENOG4107Z3H Transcriptional regulator, TetR family FJM75_RS07130 ENOG4105CEY Amp-dependent synthetase and ligase FJM75_RS07140 ENOG4105C98 muts2 protein FJM75_RS07145 ENOG4105DCG PHP domain protein FJM75_RS07155 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FJM75_RS07160 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FJM75_RS07170 ENOG4105D9N nucleoside FJM75_RS07175 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FJM75_RS07180 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FJM75_RS07185 ENOG4108RWN rrna methyltransferase FJM75_RS07190 ENOG41067MF small acid-soluble spore protein FJM75_RS07195 ENOG4105CN9 Peptidase m42 family protein FJM75_RS07235 ENOG4105VJV 50s ribosomal protein L35 FJM75_RS07240 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FJM75_RS07245 ENOG4105C22 threonyL-tRNA synthetase FJM75_RS07250 ENOG4108TDW sporulation protein YtxC FJM75_RS07265 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FJM75_RS07275 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FJM75_RS07280 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FJM75_RS07285 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FJM75_RS07300 ENOG4105C2M dna polymerase I FJM75_RS07305 ENOG4105BZU Histidine kinase FJM75_RS07310 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FJM75_RS07320 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FJM75_RS07325 ENOG4108HMX isocitrate dehydrogenase (NADP) FJM75_RS07330 ENOG4105BZN citrate synthase FJM75_RS07335 ENOG4107CWS Protein of unknown function (DUF441) FJM75_RS07340 ENOG4108REF Sporulation integral membrane protein ytvi FJM75_RS07350 ENOG4108TVJ Nitroreductase FJM75_RS07355 ENOG4105FS7 Transcriptional regulator FJM75_RS07360 ENOG4105FS0 cytoplasmic membrane protein FJM75_RS07365 ENOG4105CA9 Pyruvate kinase FJM75_RS07370 ENOG4105CTQ phosphohexokinase FJM75_RS07375 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FJM75_RS07380 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FJM75_RS07385 ENOG41073TP transcriptional regulator FJM75_RS07390 ENOG4105C6K Malic enzyme FJM75_RS07395 ENOG4105C0B DNA polymerase III (alpha subunit) FJM75_RS07400 ENOG4105VV2 FJM75_RS07410 ENOG4106EVM FJM75_RS07415 ENOG4105SFS phosphoesterase RecJ domain protein FJM75_RS07435 ENOG4105E8R UPF0173 metal-dependent hydrolase FJM75_RS07440 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FJM75_RS07455 ENOG41087YS Phage shock protein A FJM75_RS07475 ENOG41086BQ Protein CrcB homolog FJM75_RS07480 ENOG4105WMR Protein CrcB homolog FJM75_RS07500 ENOG4105EPU Molybdenum cofactor synthesis domain protein FJM75_RS07505 ENOG4105EU9 FJM75_RS07510 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FJM75_RS07520 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FJM75_RS07525 ENOG4105KBJ sporulation protein ytfj FJM75_RS07535 ENOG4105VK3 rdd domain containing protein FJM75_RS07540 ENOG4105D07 Signal peptide peptidase, SppA FJM75_RS07545 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FJM75_RS07550 ENOG4105EFZ amidohydrolase FJM75_RS07555 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FJM75_RS07560 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FJM75_RS07570 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FJM75_RS07585 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) FJM75_RS07590 ENOG4108W76 histidinol phosphate phosphatase hisj family FJM75_RS07595 ENOG4105U5Y Transcriptional regulator FJM75_RS07605 ENOG4105C28 cystathionine FJM75_RS07610 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FJM75_RS07615 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FJM75_RS07630 ENOG4105F1V Acetoin utilization protein FJM75_RS07635 ENOG4105W87 Cbs domain FJM75_RS07640 ENOG4105DGU Histone deacetylase FJM75_RS07645 ENOG4105ETE Transcriptional regulator (LacI family FJM75_RS07650 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FJM75_RS07670 ENOG4105DFU Cell wall formation (By similarity) FJM75_RS07685 ENOG4108VDD TRNA binding domain protein FJM75_RS07690 ENOG4108NKM UPF0354 protein FJM75_RS07705 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ FJM75_RS07710 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FJM75_RS07730 ENOG4105II7 pyrroline-5-carboxylate reductase FJM75_RS07735 ENOG4105DM4 PTS System FJM75_RS07740 ENOG4105DE4 1-phosphofructokinase FJM75_RS07745 ENOG4105E98 transcriptional regulator DeoR family FJM75_RS07750 ENOG4105C8F Beta-lactamase domain protein FJM75_RS07755 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FJM75_RS07765 ENOG4108V15 phosphotransferase enzyme family FJM75_RS07770 ENOG4108IUM Glycogen debranching enzyme FJM75_RS07775 ENOG41067MG lrgb family FJM75_RS07780 ENOG4105VAW lrga family FJM75_RS07790 ENOG4105C6T cysteine synthase FJM75_RS07795 ENOG4107QSE Dipeptidase FJM75_RS07800 ENOG4105EYW Ion transport protein FJM75_RS07805 ENOG4105YW5 deoR family transcriptional regulator FJM75_RS07835 ENOG4105CBX hi0933 family FJM75_RS07840 ENOG4105C1J atp-dependent rna helicase FJM75_RS07845 ENOG4105E4C Lytic transglycosylase catalytic FJM75_RS07855 ENOG41085GJ domain protein FJM75_RS07860 ENOG4105C8T Leucyl-tRNA synthetase FJM75_RS07885 ENOG4105E8V Alpha Beta Hydrolase Fold protein FJM75_RS07890 ENOG4108Z0R Transferase FJM75_RS07900 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FJM75_RS07910 ENOG4105C6Y Udp-glucose 6-dehydrogenase FJM75_RS07920 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FJM75_RS07925 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FJM75_RS07930 ENOG4105D2X ABC transporter substrate-binding protein FJM75_RS07940 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FJM75_RS07980 ENOG4105ENA helicase FJM75_RS07990 ENOG4105VCH membrane FJM75_RS07995 ENOG4105DTQ mandelate racemase muconate lactonizing FJM75_RS08000 ENOG4105CEY Amp-dependent synthetase and ligase FJM75_RS08005 ENOG4108IPT Naphthoate synthase FJM75_RS08010 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FJM75_RS08015 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FJM75_RS08020 ENOG4105E4F Isochorismate synthase FJM75_RS08030 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FJM75_RS08035 ENOG4105KA0 thioesterase Superfamily protein FJM75_RS08045 ENOG4107Y9E nuclease FJM75_RS08055 ENOG4105BZ1 (ABC) transporter FJM75_RS08060 ENOG4105BZ1 (ABC) transporter FJM75_RS08070 ENOG4105D7K pfkb domain protein FJM75_RS08075 ENOG4105C26 Dehydrogenase FJM75_RS08085 ENOG4105EWU Squalene--hopene cyclase FJM75_RS08095 ENOG4105II7 pyrroline-5-carboxylate reductase FJM75_RS08100 ENOG4107RQ2 Cytochrome c oxidase, subunit I FJM75_RS08105 ENOG4105NAA Cytochrome C oxidase, subunit II FJM75_RS08115 ENOG4107V6Q Cyclic nucleotide-binding domain FJM75_RS08140 ENOG4107JEE Short-chain dehydrogenase reductase Sdr FJM75_RS08170 ENOG410812K response regulator receiver protein FJM75_RS08185 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FJM75_RS08195 ENOG4105JVQ RNA Polymerase FJM75_RS08215 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FJM75_RS08220 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FJM75_RS08240 ENOG41069ER domain protein FJM75_RS08280 ENOG4105EUB pirin domain protein FJM75_RS08325 ENOG4105FQP Beta-lactamase FJM75_RS08345 ENOG4105DEF Extracellular solute-binding protein, family 5 FJM75_RS08355 ENOG4107EV6 Inherit from COG: YD repeat protein FJM75_RS08365 ENOG4108TF4 von Willebrand factor, type A FJM75_RS08370 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FJM75_RS08375 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FJM75_RS08380 ENOG4105CKI cobalamin synthesis protein FJM75_RS08395 ENOG4108PJD permease FJM75_RS08400 ENOG4105CKI cobalamin synthesis protein FJM75_RS08405 ENOG4105DSE periplasmic solute binding protein FJM75_RS08415 ENOG4105KVH Transcriptional regulator FJM75_RS08425 ENOG4108HKT sucrose-6-phosphate hydrolase FJM75_RS08435 ENOG4105ETE Transcriptional regulator (LacI family FJM75_RS08440 ENOG4108HKT sucrose-6-phosphate hydrolase FJM75_RS08445 ENOG4108HKT sucrose-6-phosphate hydrolase FJM75_RS08450 ENOG4105E0S extracellular solute-binding protein family 1 FJM75_RS08455 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FJM75_RS08465 ENOG4105E2A Dehydrogenase FJM75_RS08480 ENOG4105D74 hydrolase FJM75_RS08510 ENOG4105TRT Transcriptional regulator FJM75_RS08540 ENOG4105CHR reductase FJM75_RS08545 ENOG4106IQC argininosuccinate lyase FJM75_RS08550 ENOG4105E0C molybdate abc transporter FJM75_RS08555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FJM75_RS08565 ENOG4105E2R ROK family FJM75_RS08585 ENOG4108FN7 Aldo keto reductase FJM75_RS08590 ENOG4105DNP FAD linked oxidase domain protein FJM75_RS08675 ENOG4107SCJ type I restriction enzyme EcoKI subunit R FJM75_RS08720 ENOG4107PBV potassium channel FJM75_RS08735 ENOG4107QW4 alcohol dehydrogenase FJM75_RS08740 ENOG4105WG9 Conserved Protein FJM75_RS08750 ENOG4105C8J )-transporter FJM75_RS08755 ENOG4108MUZ hydrolase FJM75_RS08770 ENOG4105ENE Histidine kinase FJM75_RS08775 ENOG4105WH1 Two component transcriptional regulator luxr family FJM75_RS08785 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FJM75_RS08790 ENOG4105E0C molybdate abc transporter FJM75_RS08810 ENOG4105BZU Histidine kinase FJM75_RS08835 ENOG41069ER domain protein FJM75_RS08855 ENOG4105CEP NADH dehydrogenase FJM75_RS08860 ENOG4105CAY ferredoxin--nadp reductase FJM75_RS08870 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FJM75_RS08875 ENOG4107QP6 Xylose isomerase domain protein TIM barrel FJM75_RS08880 ENOG4105CK5 oxidoreductase FJM75_RS08920 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FJM75_RS08925 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FJM75_RS08955 ENOG41083MR nifu domain-containing protein FJM75_RS08965 ENOG4108W5N phosphatidylglycerophosphatase a FJM75_RS08970 ENOG4105D4U had-superfamily hydrolase, subfamily iia FJM75_RS08990 ENOG4105MMD transcriptional regulator FJM75_RS08995 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FJM75_RS09000 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FJM75_RS09005 ENOG4105FAA peptidase M23 FJM75_RS09015 ENOG4105C8J )-transporter FJM75_RS09020 ENOG4107S6Z Na H antiporter FJM75_RS09025 ENOG4108YTE sporulation protein YunB FJM75_RS09030 ENOG4105KZD Domain of unknown function (DUF1805) FJM75_RS09045 ENOG4105I3N Conserved Protein FJM75_RS09050 ENOG4105DIW FeS assembly protein SUFB FJM75_RS09055 ENOG4108UNV SUF system FeS assembly protein, NifU family FJM75_RS09065 ENOG4105JRK feS assembly protein SufD FJM75_RS09070 ENOG4105C3K feS assembly ATPase SufC FJM75_RS09080 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FJM75_RS09085 ENOG4105D01 (LipO)protein FJM75_RS09090 ENOG4108UMI ABC transporter, permease FJM75_RS09095 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FJM75_RS09100 ENOG4105C7B Threonine dehydratase FJM75_RS09105 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FJM75_RS09110 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FJM75_RS09120 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FJM75_RS09125 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FJM75_RS09130 ENOG4108ZP8 Acetolactate synthase small subunit FJM75_RS09135 ENOG4105C7K acetolactate synthase FJM75_RS09140 ENOG4105CM2 brancheD-chain amino acid aminotransferase FJM75_RS09150 ENOG4105DWV Homoserine O-trans-acetylase FJM75_RS09165 ENOG4108WZW RNA polymerase sigma FJM75_RS09180 ENOG4105SCY DNAK suppressor FJM75_RS09195 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FJM75_RS09205 ENOG4105C1G acyl-Coa dehydrogenase FJM75_RS09210 ENOG4105CHU acetyl-coa acetyltransferase FJM75_RS09235 ENOG4105EWK phytoene FJM75_RS09245 ENOG4108UT2 hemolysin iii FJM75_RS09250 ENOG4105CJ1 ABC, transporter FJM75_RS09260 ENOG4105EMN RNA polymerase sigma factor FJM75_RS09270 ENOG4105DA5 (ABC) transporter FJM75_RS09280 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FJM75_RS09290 ENOG4108IAB Phoh family FJM75_RS09305 ENOG4105K70 DNA-binding protein FJM75_RS09310 ENOG4108RPX mosc domain containing protein FJM75_RS09320 ENOG4105KBX Transcriptional regulator, TetR family FJM75_RS09325 ENOG4105CIG ABC transporter FJM75_RS09335 ENOG41062IR nudix hydrolase FJM75_RS09380 ENOG4108HE4 integrase family FJM75_RS09415 ENOG4105CDY transcriptional regulatory protein FJM75_RS09425 ENOG4105UBK short-chain dehydrogenase reductase FJM75_RS09430 ENOG4105VUF Transcriptional regulator FJM75_RS09435 ENOG4105BZW Glycerate kinase FJM75_RS09440 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FJM75_RS09450 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FJM75_RS09455 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FJM75_RS09470 ENOG4105EGS Mechanosensitive ion channel FJM75_RS09480 ENOG4108TU7 Inherit from COG: (ABC) transporter FJM75_RS09485 ENOG4105CJ1 ABC, transporter FJM75_RS09490 ENOG4105CZV ABC transporter FJM75_RS09495 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FJM75_RS09510 ENOG4105BZG amino acid carrier protein FJM75_RS09525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FJM75_RS09540 ENOG4105C98 muts2 protein FJM75_RS09545 ENOG4105CHR reductase FJM75_RS09550 ENOG4105BZG amino acid carrier protein FJM75_RS09555 ENOG4105BZ1 (ABC) transporter FJM75_RS09580 ENOG4105DEN Luciferase family FJM75_RS09585 ENOG4105E98 transcriptional regulator DeoR family FJM75_RS09590 ENOG4105CIY formyltetrahydrofolate deformylase FJM75_RS09615 ENOG4108N5C SNARE associated Golgi protein-related protein FJM75_RS09620 ENOG4105C37 (CBS) domain FJM75_RS09625 ENOG41087NI Sulfite exporter TauE/SafE FJM75_RS09630 ENOG4105VFE sira family FJM75_RS09635 ENOG4107TPS domain protein FJM75_RS09640 ENOG4105VFE sira family FJM75_RS09655 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FJM75_RS09660 ENOG4105XTG Pfam:DUF156 FJM75_RS09665 ENOG4105VG5 Membrane FJM75_RS09670 ENOG4105E0X reductase FJM75_RS09675 ENOG4105KVH Transcriptional regulator FJM75_RS09680 ENOG4108TGC Acyltransferase FJM75_RS09690 ENOG4107Y03 Nitroreductase FJM75_RS09710 ENOG4105CRW Short chain fatty acid transporter FJM75_RS09740 ENOG4105C01 Dihydroxy-acid dehydratase FJM75_RS09765 ENOG4105CMU LysR family (Transcriptional regulator FJM75_RS09785 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FJM75_RS09790 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FJM75_RS09800 ENOG4105XZU Preprotein translocase, subunit SecG FJM75_RS09805 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FJM75_RS09810 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FJM75_RS09820 ENOG4105BZA Phosphoglycerate kinase FJM75_RS09840 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FJM75_RS09865 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FJM75_RS09870 ENOG4105KRI phosphocarrier protein (HPr FJM75_RS09875 ENOG4105CIE May be required for sporulation (By similarity) FJM75_RS09880 ENOG4105CHW UPF0052 protein FJM75_RS09885 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FJM75_RS09890 ENOG4108Z4K mutator MutT protein FJM75_RS09895 ENOG4105C3M thioredoxin reductase FJM75_RS09910 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FJM75_RS09915 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FJM75_RS09920 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FJM75_RS09925 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FJM75_RS09930 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FJM75_RS09935 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FJM75_RS09940 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FJM75_RS09945 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FJM75_RS09950 ENOG4105UPD Calcium Proton FJM75_RS09955 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FJM75_RS09960 ENOG4108S4C acetyltransferase FJM75_RS09965 ENOG4107XGZ Hydrolase FJM75_RS09970 ENOG4105HKU nucleoside recognition domain-containing protein FJM75_RS09985 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FJM75_RS10000 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FJM75_RS10005 ENOG41086DT Membrane protein of unknown function FJM75_RS10010 ENOG4108PY7 FJM75_RS10020 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FJM75_RS10025 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FJM75_RS10030 ENOG41087NI Sulfite exporter TauE/SafE FJM75_RS10040 ENOG4108S4H thioesterase Superfamily protein FJM75_RS10055 ENOG4105CN1 protease FJM75_RS10060 ENOG4105DR5 peptidase FJM75_RS10065 ENOG4105CRP Part of the ABC transporter FtsEX involved in FJM75_RS10070 ENOG4105CAK Cell division ATP-binding protein ftsE FJM75_RS10090 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FJM75_RS10095 ENOG4105MS2 ribosomal subunit Interface protein FJM75_RS10100 ENOG4105VEQ Cold shock protein FJM75_RS10105 ENOG41081UC Inherit from COG: Competence protein FJM75_RS10135 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FJM75_RS10140 ENOG4105ESV Glycosyl transferase, family 4 FJM75_RS10165 ENOG4108KGH TRANSCRIPTIONal FJM75_RS10180 ENOG4107EF8 Glycosyl transferase (Group 1 FJM75_RS10185 ENOG4105CPK Glycosyl transferase (Group 1 FJM75_RS10195 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FJM75_RS10200 ENOG4107QQG Dehydrogenase FJM75_RS10205 ENOG4105CK5 oxidoreductase FJM75_RS10215 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FJM75_RS10220 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin FJM75_RS10250 ENOG4105JFG SpoIID LytB domain protein FJM75_RS10275 ENOG4105C6Y Udp-glucose 6-dehydrogenase FJM75_RS10290 ENOG4108IEG Formate dehydrogenase Alpha subunit FJM75_RS10315 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FJM75_RS10330 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FJM75_RS10335 ENOG41075H3 AraC family transcriptional regulator FJM75_RS10340 ENOG4105C2F Histidine kinase FJM75_RS10355 ENOG4105BZ1 (ABC) transporter FJM75_RS10360 ENOG4105BZ1 (ABC) transporter FJM75_RS10365 ENOG4105DG6 mannose-6-phosphate isomerase FJM75_RS10370 ENOG4105DKQ ROK family FJM75_RS10380 ENOG4105DHT Metal Dependent Phosphohydrolase FJM75_RS10385 ENOG4105CMG Carbohydrate kinase FJM75_RS10395 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FJM75_RS10400 ENOG4108JUB Transcriptional regulator FJM75_RS10410 ENOG4105C0A alcohol dehydrogenase FJM75_RS10430 ENOG4105D2N Aldolase FJM75_RS10435 ENOG4105CMD Transcriptional regulator, GntR family FJM75_RS10440 ENOG4105CTQ phosphohexokinase FJM75_RS10450 ENOG4105CJQ hydrolase, family 31 FJM75_RS10455 ENOG4107RUZ Sss sodium solute transporter superfamily FJM75_RS10485 ENOG4105CMR udp-glucose 4-epimerase FJM75_RS10490 ENOG4105C4C beta-galactosidase FJM75_RS10495 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FJM75_RS10500 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FJM75_RS10530 ENOG4108JE9 extracellular solute-binding protein family 1 FJM75_RS10540 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FJM75_RS10545 ENOG4105CMR udp-glucose 4-epimerase FJM75_RS10560 ENOG4107SJB teichoic acid biosynthesis FJM75_RS10565 ENOG4107SJB teichoic acid biosynthesis FJM75_RS10570 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FJM75_RS10585 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FJM75_RS10600 ENOG4105CVJ phosphoglycerate mutase FJM75_RS10615 ENOG4107SCQ Iron-containing alcohol dehydrogenase FJM75_RS10620 ENOG4105DMF Dehydrogenase FJM75_RS10625 ENOG4108UMI ABC transporter, permease FJM75_RS10630 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FJM75_RS10635 ENOG4105D01 (LipO)protein FJM75_RS10640 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FJM75_RS10655 ENOG4105BZ1 (ABC) transporter FJM75_RS10680 ENOG4105DIN metallophosphoesterase FJM75_RS10685 ENOG4105BZ1 (ABC) transporter FJM75_RS10705 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FJM75_RS10765 ENOG4108KMV Glycosyl transferase (Group 1 FJM75_RS10770 ENOG4108KMV Glycosyl transferase (Group 1 FJM75_RS10780 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FJM75_RS10785 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family FJM75_RS10790 ENOG4105D3Q Sugar transferase FJM75_RS10800 ENOG41068W6 Capsular polysaccharide biosynthesis protein FJM75_RS10805 ENOG4107SJB teichoic acid biosynthesis FJM75_RS10810 ENOG4108KMV Glycosyl transferase (Group 1 FJM75_RS10815 ENOG4108PQP glycosyl transferase group 1 FJM75_RS10825 ENOG4107YJ4 chain length determinant protein FJM75_RS10830 ENOG4105HTX biosynthesis protein FJM75_RS10835 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FJM75_RS10855 ENOG4108JP0 extracellular solute-binding protein family 1 FJM75_RS10865 ENOG4106KNT transcriptional regulator FJM75_RS10870 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FJM75_RS10885 ENOG4105EHZ conserved protein UCP016719 FJM75_RS10890 ENOG4105D17 glycoside hydrolase, family 3 domain protein FJM75_RS10915 ENOG4108MRH transcriptional regulatory protein FJM75_RS10920 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FJM75_RS10935 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FJM75_RS10940 ENOG4108626 Racemase FJM75_RS10945 ENOG4106PKC pyridoxal phosphate binding FJM75_RS10950 ENOG41080QX K07048 phosphotriesterase-related protein FJM75_RS10955 ENOG4106M0N transport system permease protein FJM75_RS10960 ENOG4105MUZ Protein of unknown function DUF2620 FJM75_RS10970 ENOG4108M21 FJM75_RS10985 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FJM75_RS11005 ENOG4105C5I Dehydrogenase FJM75_RS11010 ENOG4107YD3 Thioesterase FJM75_RS11020 ENOG4105IIU Aminopeptidase FJM75_RS11025 ENOG4108IA2 Sodium pantothenate symporter FJM75_RS11045 ENOG4105KT7 mgtC SapB transporter FJM75_RS11050 ENOG4105KT7 mgtC SapB transporter FJM75_RS11055 ENOG4108JYZ YitT family FJM75_RS11065 ENOG4105DUX Transporter FJM75_RS11080 ENOG4105CUB amino acid FJM75_RS11085 ENOG4108JPW Aminotransferase FJM75_RS11090 ENOG4107XBN GntR Family Transcriptional Regulator FJM75_RS11095 ENOG4105FGV Chromate FJM75_RS11100 ENOG4105CAH Chromate FJM75_RS11105 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FJM75_RS11110 ENOG4107VFR oxidoreductase FJM75_RS11130 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FJM75_RS11135 ENOG4105DZS Phenylacetate-CoA ligase FJM75_RS11140 ENOG4108VXD carboxy-peptidase FJM75_RS11155 ENOG4105BZU Histidine kinase FJM75_RS11175 ENOG4105JVQ RNA Polymerase FJM75_RS11185 ENOG4108IUM Glycogen debranching enzyme FJM75_RS11200 ENOG4108CWB sugar kinase ygcE FJM75_RS11210 ENOG4105CHR reductase FJM75_RS11230 ENOG4105BZU Histidine kinase FJM75_RS11260 ENOG4105C19 ABC transporter FJM75_RS11265 ENOG4107RBB ABC transporter, permease FJM75_RS11305 ENOG4105DA5 (ABC) transporter FJM75_RS11320 ENOG4105DY9 regulatoR FJM75_RS11335 ENOG4107S1V Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FJM75_RS11365 ENOG4105DQ5 transport system permease protein FJM75_RS11370 ENOG4108HUF Transporter FJM75_RS11375 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FJM75_RS11385 ENOG4105GMB type VI secretion system effector, hcp1 family FJM75_RS11430 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FJM75_RS11445 ENOG4105CG5 Glycosyl transferase (Group 1 FJM75_RS11450 ENOG4107SJB teichoic acid biosynthesis FJM75_RS11455 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FJM75_RS11470 ENOG4105C6Z Gluconate FJM75_RS11475 ENOG4105CXK mandelate racemase muconate lactonizing FJM75_RS11485 ENOG4105D7K pfkb domain protein FJM75_RS11490 ENOG4107HP6 Transcriptional regulator FJM75_RS11495 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FJM75_RS11500 ENOG4105DG6 mannose-6-phosphate isomerase FJM75_RS11520 ENOG4106CD9 glycosyl transferase group 1 FJM75_RS11525 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase FJM75_RS11545 ENOG4105C0K Gdp-mannose 4,6-dehydratase FJM75_RS11550 ENOG4105C30 Nad-dependent epimerase dehydratase FJM75_RS11555 ENOG4105D3Q Sugar transferase FJM75_RS11560 ENOG4107YJ4 chain length determinant protein FJM75_RS11565 ENOG4105HTX biosynthesis protein FJM75_RS11570 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FJM75_RS11590 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FJM75_RS11625 ENOG4108WBT adenosyltransferase FJM75_RS11640 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FJM75_RS11645 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FJM75_RS11655 ENOG4107QZB decarboxylase FJM75_RS11660 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FJM75_RS11665 ENOG4105E0A ABC, transporter FJM75_RS11670 ENOG4105EHG Permease protein FJM75_RS11675 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FJM75_RS11680 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FJM75_RS11685 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FJM75_RS11690 ENOG4105BZU Histidine kinase FJM75_RS11695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FJM75_RS11725 ENOG4107RIQ Sulfate adenylate transferase FJM75_RS11735 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) FJM75_RS11765 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FJM75_RS11770 ENOG4105E0M Sulfatase FJM75_RS11775 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FJM75_RS11785 ENOG4105JFG SpoIID LytB domain protein FJM75_RS11795 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FJM75_RS11800 ENOG4105CGH 5'-nucleotidase FJM75_RS11810 ENOG4105C79 DNA protecting protein DprA FJM75_RS11825 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FJM75_RS11880 ENOG4105DFF Rod shape-determining protein mreb FJM75_RS11885 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FJM75_RS11890 ENOG4107QN1 sodium solute FJM75_RS11900 ENOG4105FRN stage II sporulation protein FJM75_RS11915 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FJM75_RS11925 ENOG4106778 Protein of unknown function (DUF1146) FJM75_RS11930 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FJM75_RS11940 ENOG4105D65 subunit l FJM75_RS11945 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FJM75_RS11955 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FJM75_RS11960 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FJM75_RS11965 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FJM75_RS11970 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FJM75_RS11975 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FJM75_RS11995 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FJM75_RS12000 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FJM75_RS12005 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FJM75_RS12010 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FJM75_RS12015 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FJM75_RS12020 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FJM75_RS12025 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FJM75_RS12030 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FJM75_RS12035 ENOG41062M3 atp synthase FJM75_RS12045 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FJM75_RS12055 ENOG4108UIC UPF0340 protein FJM75_RS12060 ENOG4108YZG isomerase FJM75_RS12070 ENOG4107QJR hflk protein FJM75_RS12090 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FJM75_RS12100 ENOG4108ZXQ stage ii sporulation protein r FJM75_RS12105 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FJM75_RS12110 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FJM75_RS12115 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FJM75_RS12125 ENOG4107104 thymidine kinase FJM75_RS12130 ENOG4105VFB Binds the 23S rRNA (By similarity) FJM75_RS12135 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FJM75_RS12140 ENOG4105CBT Fructose-1,6-bisphosphatase FJM75_RS12145 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FJM75_RS12155 ENOG4105D2N Aldolase FJM75_RS12160 ENOG410812K response regulator receiver protein FJM75_RS12170 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FJM75_RS12175 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) FJM75_RS12180 ENOG4105D5P Methylmalonyl-coA mutase FJM75_RS12185 ENOG4105YA8 Transcriptional regulator FJM75_RS12195 ENOG4105C1G acyl-Coa dehydrogenase FJM75_RS12200 ENOG4105C1G acyl-Coa dehydrogenase FJM75_RS12205 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FJM75_RS12215 ENOG4105DF6 Fe-S oxidoreductase FJM75_RS12225 ENOG4105E5J UV damage endonuclease FJM75_RS12250 ENOG4105CYW agmatinase FJM75_RS12265 ENOG4105BZ4 penicillin-binding protein FJM75_RS12275 ENOG4108XFG YwhD family FJM75_RS12280 ENOG4105C7N Xanthine uracil vitamin C permease FJM75_RS12285 ENOG4105D9R oxidoreductase FJM75_RS12300 ENOG4105DCI Phosphohydrolase FJM75_RS12310 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FJM75_RS12315 ENOG4108IJ2 phosphate acetyltransferase FJM75_RS12370 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FJM75_RS12380 ENOG4105FZW flagellar biosynthesis regulator FlhF FJM75_RS12385 ENOG4105D7B Flagellar biosynthesis protein flha FJM75_RS12390 ENOG4105D00 flagellar biosynthetic protein flhB FJM75_RS12395 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FJM75_RS12400 ENOG4105VS8 Flagellar biosynthetic protein fliq FJM75_RS12405 ENOG4105CN7 Flagellar biosynthetic protein FliP FJM75_RS12415 ENOG4105DD5 Flagellar motor switch protein FJM75_RS12420 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FJM75_RS12430 ENOG4108JQA flagellar FJM75_RS12440 ENOG410822I Flagellar hook capping protein FJM75_RS12445 ENOG410696Y Flagellar hook-length control protein FJM75_RS12470 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FJM75_RS12475 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FJM75_RS12480 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FJM75_RS12485 ENOG4108ZC9 flagellar basal-body rod protein flgc FJM75_RS12490 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FJM75_RS12500 ENOG4105CGA flagellar basal-body rod protein FlgG FJM75_RS12505 ENOG4105DTJ flagellar hook-associated protein FJM75_RS12510 ENOG4105E1Q flagellar hook-associated protein FJM75_RS12530 ENOG4105ER2 Ompa motb domain protein FJM75_RS12535 ENOG4105E14 MotA TolQ exbB proton channel FJM75_RS12540 ENOG4105MQ3 flagellar protein FliS FJM75_RS12550 ENOG4107RT6 flagellar hook-associated FJM75_RS12555 ENOG41083S7 flagellar protein FlaG FJM75_RS12560 ENOG4105I03 Flagellin FJM75_RS12570 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FJM75_RS12575 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FJM75_RS12580 ENOG4105P4J Allophanate hydrolase, subunit 1 FJM75_RS12585 ENOG4105E7W lamb ycsf family protein FJM75_RS12615 ENOG4108V2W Carbonate dehydratase FJM75_RS12620 ENOG4107R7Y intracellular protease Pfpi family FJM75_RS12625 ENOG4107TS3 membrane protein, TerC FJM75_RS12640 ENOG4105EMN RNA polymerase sigma factor FJM75_RS12650 ENOG4105C9Q fumarate hydratase class II FJM75_RS12665 ENOG4105H1G trap transporter solute receptor taxi family FJM75_RS12675 ENOG4108V3A UPF0421 protein FJM75_RS12690 ENOG4108V06 Glutathione peroxidase FJM75_RS12710 ENOG4108RNG Permease of the drug metabolite transporter FJM75_RS12725 ENOG4105DQ5 transport system permease protein FJM75_RS12730 ENOG4108MES Periplasmic binding protein FJM75_RS12740 ENOG4105DEU major facilitator superfamily FJM75_RS12750 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FJM75_RS12760 ENOG4105CS1 NAD(P)H quinone oxidoreductase FJM75_RS12765 ENOG41090MY MarR family Transcriptional regulator FJM75_RS12770 ENOG4105K56 Transcriptional regulator FJM75_RS12775 ENOG4108ZHJ Organic hydroperoxide resistance protein FJM75_RS12785 ENOG4106TD9 Diguanylate cyclase FJM75_RS12790 ENOG4105C1Q protoporphyrinogen oxidase FJM75_RS12795 ENOG4105E0X reductase FJM75_RS12810 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FJM75_RS12860 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FJM75_RS12880 ENOG4105C26 Dehydrogenase FJM75_RS12890 ENOG4108J5H Homocysteine s-methyltransferase FJM75_RS12895 ENOG4108IQI permease FJM75_RS12910 ENOG4105WAB arsR family transcriptional regulator FJM75_RS12945 ENOG4105CCU oxidase (Subunit III) FJM75_RS12950 ENOG4105BZ9 Cytochrome C oxidase, subunit I FJM75_RS12975 ENOG4108J8C transporter major facilitator family protein FJM75_RS12990 ENOG4105C9U ATP-dependent DNA helicase RecQ FJM75_RS12995 ENOG4105CPI Metal Dependent Phosphohydrolase FJM75_RS13010 ENOG4105CPN adenine deaminase FJM75_RS13015 ENOG4107QW4 alcohol dehydrogenase FJM75_RS13020 ENOG4105EPC oxidoreductase FJM75_RS13025 ENOG4108VJ1 Transcriptional regulator (CarD family FJM75_RS13030 ENOG4105CMG Carbohydrate kinase FJM75_RS13040 ENOG4106KNT transcriptional regulator FJM75_RS13045 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FJM75_RS13055 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FJM75_RS13065 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta FJM75_RS13070 ENOG4105C26 Dehydrogenase FJM75_RS13075 ENOG4105C0A alcohol dehydrogenase FJM75_RS13085 ENOG4105DR4 Methyltransferase FJM75_RS13090 ENOG4108J8C transporter major facilitator family protein FJM75_RS13100 ENOG4105CJ1 ABC, transporter FJM75_RS13130 ENOG4108SU4 UPF0309 protein FJM75_RS13140 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FJM75_RS13145 ENOG4105CE4 GlcNAc 6-P deacetylase FJM75_RS13150 ENOG4105CI1 PTS System FJM75_RS13165 ENOG4105DWT malate dehydrogenase (quinone) FJM75_RS13175 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FJM75_RS13185 ENOG4105C0H protease FJM75_RS13190 ENOG4105Q2H domain protein FJM75_RS13205 ENOG4105BZU Histidine kinase FJM75_RS13210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FJM75_RS13215 ENOG4105E4C Lytic transglycosylase catalytic FJM75_RS13245 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FJM75_RS13250 ENOG4105CDU Replicative dna helicase FJM75_RS13255 ENOG41082B8 Binds to the 23S rRNA (By similarity) FJM75_RS13260 ENOG4105BZR domain protein FJM75_RS13265 ENOG4108XMW Membrane FJM75_RS13275 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FJM75_RS13280 ENOG4108UUM single-stranded DNA-binding protein FJM75_RS13290 ENOG4105C3G gtp-binding protein FJM75_RS13295 ENOG4105VDK protein, conserved in bacteria FJM75_RS13300 ENOG4105D8X mechanosensitive ion channel FJM75_RS13310 ENOG4108ZDA Sporulation protein YyaC FJM75_RS13320 ENOG4105C9B Cysteine desulfurase FJM75_RS13325 ENOG4105FA0 parb-like partition protein FJM75_RS13330 ENOG4107QJE Chromosome Partitioning Protein FJM75_RS13345 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FJM75_RS13350 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FJM75_RS13355 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein FJM75_RS13375 ENOG4105VG0 50S ribosomal protein l34 FJM75_RS13380 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FJM75_RS13385 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FJM75_RS13390 ENOG410848D S4 domain protein YaaA FJM75_RS13395 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FJM75_RS13405 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FJM75_RS13410 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FJM75_RS13435 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FJM75_RS13445 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FJM75_RS13450 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FJM75_RS13455 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FJM75_RS13465 ENOG4105ZMH deoxynucleoside kinase FJM75_RS13480 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FJM75_RS13485 ENOG4107XWI flavin reductase domain protein, FMN-binding FJM75_RS13490 ENOG4105ERH Fumarylacetoacetate hydrolase FJM75_RS13515 ENOG4105GTG Isochorismatase FJM75_RS13520 ENOG4108Z6B deaminase FJM75_RS13535 ENOG4105C6E dna polymerase iii FJM75_RS13540 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FJM75_RS13545 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FJM75_RS13580 ENOG4105CXN decarboxylase FJM75_RS13585 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FJM75_RS13590 ENOG4105X0R protein from nitrogen regulatory protein P-II FJM75_RS13595 ENOG4105FA2 dna polymerase iii FJM75_RS13600 ENOG4105MA4 psp1 domain protein FJM75_RS13605 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) FJM75_RS13610 ENOG41060K3 Methyltransferase FJM75_RS13615 ENOG4105VC4 domain protein FJM75_RS13620 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FJM75_RS13625 ENOG4105KRN Transcriptional regulator, abrb family FJM75_RS13635 ENOG4105F8V Hydrolase, tatD family FJM75_RS13640 ENOG41069ER domain protein FJM75_RS13645 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FJM75_RS13650 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FJM75_RS13655 ENOG4105XFA sporulation peptidase YabG FJM75_RS13660 ENOG4105W42 Veg protein FJM75_RS13670 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FJM75_RS13675 ENOG4105DFT pur operon repressor FJM75_RS13680 ENOG4105KME endoribonuclease L-psp FJM75_RS13690 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FJM75_RS13695 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FJM75_RS13700 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FJM75_RS13715 ENOG4108JA2 transcriptioN-repair coupling factor FJM75_RS13720 ENOG4108M14 stage v sporulation protein t FJM75_RS13730 ENOG4108IY2 MazG family FJM75_RS13735 ENOG41082I2 s4 domain protein FJM75_RS13740 ENOG4105VYY sporulation protein yabp FJM75_RS13755 ENOG41060GV RNA binding s1 domain protein FJM75_RS13785 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FJM75_RS13790 ENOG4108UGV hypoxanthine phosphoribosyltransferase FJM75_RS13795 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FJM75_RS13800 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FJM75_RS13805 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FJM75_RS13810 ENOG4105C6T cysteine synthase FJM75_RS13815 ENOG4105CRQ synthase (Component I) FJM75_RS13820 ENOG4105DDQ anthranilate synthase FJM75_RS13825 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FJM75_RS13830 ENOG4105EEI dihydropteroate synthase FJM75_RS13835 ENOG4105KRF dihydroneopterin aldolase FJM75_RS13840 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FJM75_RS13850 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FJM75_RS13855 ENOG4105CRK lysyL-tRNA synthetase FJM75_RS13945 ENOG4108Z0C Uvrb UvrC protein FJM75_RS13950 ENOG41066A3 ATP guanido phosphotransferase FJM75_RS13960 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FJM75_RS13965 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FJM75_RS13970 ENOG4105CTP PilT protein domain protein FJM75_RS13975 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FJM75_RS13980 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FJM75_RS13985 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FJM75_RS13990 ENOG4105D7W serine acetyltransferase FJM75_RS13995 ENOG4105C8N cysteinyl-tRNA synthetase FJM75_RS14005 ENOG4105C2N RNA methyltransferase TrmH family group 3 FJM75_RS14010 ENOG4105M0M Tetracycline resistance protein FJM75_RS14015 ENOG4105QIV RNA polymerase FJM75_RS14025 ENOG410683Z Preprotein translocase SecE subunit FJM75_RS14030 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FJM75_RS14035 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FJM75_RS14040 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FJM75_RS14045 ENOG4108VZM 50s ribosomal protein L10 FJM75_RS14050 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FJM75_RS14055 ENOG4107Y49 methyltransferase FJM75_RS14060 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FJM75_RS14065 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FJM75_RS14070 ENOG4105XPM ribosomal protein FJM75_RS14075 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FJM75_RS14080 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FJM75_RS14085 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FJM75_RS14090 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FJM75_RS14100 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FJM75_RS14105 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FJM75_RS14110 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FJM75_RS14115 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FJM75_RS14120 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FJM75_RS14125 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FJM75_RS14130 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FJM75_RS14140 ENOG41082SA 50s ribosomal protein l29 FJM75_RS14145 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FJM75_RS14150 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FJM75_RS14155 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FJM75_RS14160 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FJM75_RS14165 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FJM75_RS14170 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FJM75_RS14175 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FJM75_RS14180 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FJM75_RS14185 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FJM75_RS14190 ENOG4105VPB 50S ribosomal protein L30 FJM75_RS14200 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FJM75_RS14205 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FJM75_RS14210 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FJM75_RS14220 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FJM75_RS14230 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FJM75_RS14240 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FJM75_RS14245 ENOG4108ZT0 50S ribosomal protein l17 FJM75_RS14250 ENOG4108JJB ABC transporter FJM75_RS14260 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FJM75_RS14265 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FJM75_RS14275 ENOG4108UJD 30S ribosomal protein S9 FJM75_RS14290 ENOG4105D1F ATP-binding protein FJM75_RS14305 ENOG4108NMV polysaccharide deacetylase FJM75_RS14390 ENOG4105EMN RNA polymerase sigma factor FJM75_RS14400 ENOG4105C8B TIGR00159 family FJM75_RS14405 ENOG4107U5W ybbr family FJM75_RS14410 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FJM75_RS14415 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FJM75_RS14445 ENOG4105VPX protein, conserved in bacteria FJM75_RS14475 ENOG4105ETD TRANSCRIPTIONal FJM75_RS14485 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FJM75_RS14495 ENOG4108S4H thioesterase Superfamily protein FJM75_RS14505 ENOG4105PXI polysaccharide deacetylase FJM75_RS14510 ENOG4105VKD bioY protein FJM75_RS14520 ENOG4107QM2 Aldo Keto reductase FJM75_RS14535 ENOG4105DC7 peptidase M24 FJM75_RS14545 ENOG4105K63 Thioredoxin FJM75_RS14550 ENOG4105EMU Dehydrogenase FJM75_RS14560 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FJM75_RS14575 ENOG4108Z7R Chaperone CsaA FJM75_RS14585 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FJM75_RS14590 ENOG4105EPR degv family FJM75_RS14620 ENOG410905X membrane-flanked domain protein FJM75_RS14625 ENOG4105CKV Membrane FJM75_RS14655 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FJM75_RS14660 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FJM75_RS14665 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FJM75_RS14680 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FJM75_RS14685 ENOG4107MMM Anti-sigma-factor antagonist FJM75_RS14690 ENOG4105FUA antagonist FJM75_RS14695 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FJM75_RS14700 ENOG4107SGM protein serine threonine phosphatase FJM75_RS14705 ENOG4105WN5 stage II sporulation protein FJM75_RS14710 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FJM75_RS14720 ENOG41064BQ Phosphatase FJM75_RS14830 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FJM75_RS14835 ENOG4105K8N protein family UPF0079, ATPase FJM75_RS14840 ENOG41072GX Peptidase M22 Glycoprotease FJM75_RS14845 ENOG410801F ribosomal-protein-alanine acetyltransferase FJM75_RS14850 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FJM75_RS14855 ENOG4105C5H ABC transporter FJM75_RS14865 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FJM75_RS14870 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FJM75_RS14875 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FJM75_RS14885 ENOG4108TYN CAAX amino terminal protease family protein FJM75_RS14890 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FJM75_RS14895 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FJM75_RS14930 ENOG4105JXH GntR family transcriptional regulator FJM75_RS14935 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FJM75_RS14940 ENOG4107QR9 Iron-sulfur cluster binding protein FJM75_RS14945 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FJM75_RS14960 ENOG4105CH6 catalase FJM75_RS14965 ENOG4105E2A Dehydrogenase FJM75_RS14970 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FJM75_RS14985 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FJM75_RS14990 ENOG4105C7N Xanthine uracil vitamin C permease FJM75_RS15075 ENOG4108U5N UPF0316 protein FJM75_RS15085 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FJM75_RS15090 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FJM75_RS15095 ENOG4105C83 adenylosuccinate lyase FJM75_RS15100 ENOG4105C8V SAICAR synthetase FJM75_RS15105 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FJM75_RS15125 ENOG4105CXB phosphoribosylaminoimidazole synthetase FJM75_RS15130 ENOG4108V3E phosphoribosylglycinamide formyltransferase FJM75_RS15135 ENOG4105DC1 bifunctional purine biosynthesis protein purh FJM75_RS15140 ENOG4105C12 Phosphoribosylglycinamide synthetase FJM75_RS15155 ENOG4105KGF protein, YerC YecD FJM75_RS15160 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) FJM75_RS15165 ENOG4105C4R Atp-dependent dna helicase FJM75_RS15170 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FJM75_RS15185 ENOG4105CK7 Sodium proline symporter FJM75_RS15190 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FJM75_RS15195 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FJM75_RS15200 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FJM75_RS15205 ENOG4105CBD Diacylglycerol kinase FJM75_RS15210 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FJM75_RS15220 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FJM75_RS15225 ENOG410667J hydrolase FJM75_RS15230 ENOG4105C26 Dehydrogenase FJM75_RS15245 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FJM75_RS15250 ENOG4107RSM transcriptional regulator FJM75_RS15255 ENOG4108S01 response regulator FJM75_RS15260 ENOG4108ZGX Histidine kinase FJM75_RS15265 ENOG4105ECK Fatty Acid Desaturase FJM75_RS15270 ENOG41080HJ 6-phospho 3-hexuloisomerase FJM75_RS15275 ENOG4108VA3 3-hexulose-6-phosphate synthase FJM75_RS15280 ENOG4105KVH Transcriptional regulator FJM75_RS15295 ENOG4105DAA L-lactate FJM75_RS15300 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FJM75_RS15325 ENOG4108NEV two component transcriptional regulator, LytTR family FJM75_RS15335 ENOG4108JUB Transcriptional regulator FJM75_RS15340 ENOG4105C8Y Acetylornithine aminotransferase FJM75_RS15345 ENOG4105D82 Glutamate dehydrogenase FJM75_RS15355 ENOG4105DFD Na H antiporter FJM75_RS15360 ENOG4105KWG Pfam:DUF1696 FJM75_RS15365 ENOG4107YUH hydrolase FJM75_RS15370 ENOG4107KJX Transcriptional regulator FJM75_RS15385 ENOG4105DRS transport system, permease FJM75_RS15410 ENOG4105DM4 PTS System FJM75_RS15425 ENOG4105MUA Resistance protein FJM75_RS15430 ENOG4108N0M stress protein FJM75_RS15435 ENOG4106FN3 tellurium resistance protein FJM75_RS15440 ENOG4106FN3 tellurium resistance protein FJM75_RS15445 ENOG4107TS3 membrane protein, TerC FJM75_RS15460 ENOG4105DAX Pfam:DUF2983 FJM75_RS15470 ENOG4108TTB tellurium resistance protein FJM75_RS15495 ENOG4105DWK Membrane FJM75_RS15500 ENOG4107XM3 UPF0442 protein FJM75_RS15510 ENOG4107ZQN disulfide bond FJM75_RS15515 ENOG4108S4H thioesterase Superfamily protein FJM75_RS15520 ENOG4105C02 permease FJM75_RS15525 ENOG4105DEN Luciferase family FJM75_RS15530 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FJM75_RS15535 ENOG4108TGR phosphatase FJM75_RS15540 ENOG4105BZG amino acid carrier protein FJM75_RS15545 ENOG4105CZM Major Facilitator FJM75_RS15550 ENOG4107MII Sugar-specific transcriptional regulator TrmB FJM75_RS15570 ENOG4107QJZ Glycosyl transferase, family 2 FJM75_RS15580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FJM75_RS15585 ENOG4105BZU Histidine kinase FJM75_RS15590 ENOG4105C5H ABC transporter FJM75_RS15595 ENOG4108K8S endonuclease I FJM75_RS15600 ENOG4105WEF catalase FJM75_RS15625 ENOG4105DWD nucleoside recognition domain protein FJM75_RS15630 ENOG4108JPW Aminotransferase FJM75_RS15650 ENOG4105EEM helicase FJM75_RS15685 ENOG4105ENE Histidine kinase FJM75_RS15690 ENOG4105WH1 Two component transcriptional regulator luxr family FJM75_RS15695 ENOG4108JYZ YitT family FJM75_RS15705 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FJM75_RS15710 ENOG4108NA0 Uncharacterized conserved protein (COG2071) FJM75_RS15715 ENOG4105FR1 rard protein FJM75_RS15755 ENOG410855V Acylphosphatase FJM75_RS15765 ENOG4105BZU Histidine kinase FJM75_RS15770 ENOG4105EPM Diguanylate phosphodiesterase FJM75_RS15775 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FJM75_RS15780 ENOG4105KJF protein tyrosine phosphatase FJM75_RS15795 ENOG4107U9T Pfam:Ribonuclease_BN FJM75_RS15800 ENOG4105C59 p-type ATPase FJM75_RS15820 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FJM75_RS15825 ENOG4108ISG Major Facilitator FJM75_RS15835 ENOG410606W general stress protein FJM75_RS15865 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FJM75_RS15885 ENOG4105CI2 imidazolone-5-propionate hydrolase FJM75_RS15890 ENOG4105ECP epimerase FJM75_RS15895 ENOG410902V Modulates RecA activity (By similarity) FJM75_RS15900 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr FJM75_RS15925 ENOG41067AE Membrane-bound metal-dependent hydrolase FJM75_RS15930 ENOG4105CEN a g-specific adenine glycosylase FJM75_RS15935 ENOG4105CHR reductase FJM75_RS15950 ENOG4108RAV Conserved protein FJM75_RS15960 ENOG4105EVI UPF0374 protein FJM75_RS15965 ENOG4105BZ1 (ABC) transporter FJM75_RS15970 ENOG4105C3U ABC transporter FJM75_RS15975 ENOG4108JQ7 (ABC) transporter FJM75_RS15980 ENOG4105DEF Extracellular solute-binding protein, family 5 FJM75_RS15985 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FJM75_RS15990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FJM75_RS15995 ENOG4107NBY Membrane FJM75_RS16000 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FJM75_RS16005 ENOG4108IUW ABC transporter FJM75_RS16040 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FJM75_RS16050 ENOG4108WBT adenosyltransferase FJM75_RS16055 ENOG4105G5W regulator Fur family FJM75_RS16165 ENOG410900G Protein of unknown function (DUF421) FJM75_RS16170 ENOG4107ZXU DSBA oxidoreductase FJM75_RS16180 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FJM75_RS16190 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FJM75_RS16195 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FJM75_RS16210 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FJM75_RS16230 ENOG4105CYN Serine protein kinase FJM75_RS16250 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FJM75_RS16255 ENOG41080XP Cbs domain FJM75_RS16260 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FJM75_RS16275 ENOG4105XTG Pfam:DUF156 FJM75_RS16280 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FJM75_RS16295 ENOG4105D64 Mechanosensitive ion channel FJM75_RS16300 ENOG4105C09 Bile acid FJM75_RS16305 ENOG4105ED1 spovr family FJM75_RS16335 ENOG4105E5Q amino acid AbC transporter FJM75_RS16340 ENOG4105EAB amino acid AbC transporter FJM75_RS16365 ENOG410839P FJM75_RS16370 ENOG410839P FJM75_RS16375 ENOG410839P FJM75_RS16390 ENOG4105WZB UPF0342 protein FJM75_RS16405 ENOG4105C26 Dehydrogenase FJM75_RS16415 ENOG4108IUX (ABC) transporter FJM75_RS16420 ENOG4105RHA ABC transporter, permease FJM75_RS16430 ENOG4106D4I domain protein FJM75_RS16440 ENOG4105F3H Histidine kinase FJM75_RS16445 ENOG4105EQI Metal Dependent Phosphohydrolase FJM75_RS16460 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FJM75_RS16485 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) FJM75_RS16505 ENOG4105NBU tryptophan transport protein FJM75_RS16510 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FJM75_RS16520 ENOG4105K59 histidine triad (HIT) protein FJM75_RS16545 ENOG4107RKG DJ-1/PfpI family FJM75_RS16555 ENOG410841Q phosphoesterase PA-phosphatase related protein FJM75_RS16560 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FJM75_RS16565 ENOG4105TMB Formate nitrite transporter FJM75_RS16575 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FJM75_RS16580 ENOG4105BZ4 penicillin-binding protein FJM75_RS16585 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FJM75_RS16590 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FJM75_RS16595 ENOG4105C1Q protoporphyrinogen oxidase FJM75_RS16600 ENOG4108HGU Histidine kinase FJM75_RS16610 ENOG4105ECB domain protein FJM75_RS16615 ENOG4108IJ8 ABC transporter FJM75_RS16625 ENOG4108HQR Glycine betaine FJM75_RS16635 ENOG4107SQ8 Glycine betaine FJM75_RS16640 ENOG4108IJ7 Glycine betaine FJM75_RS16645 ENOG4105TRT Transcriptional regulator FJM75_RS16650 ENOG4105CDA abc transporter atp-binding protein FJM75_RS16660 ENOG4105CV1 Transketolase (EC 2.2.1.1) FJM75_RS16665 ENOG4107RHR regulatoR FJM75_RS16670 ENOG4108RQ5 Beta-lactamase domain-containing protein FJM75_RS16680 ENOG4105DF9 Lipoate-protein, ligase FJM75_RS16685 ENOG4105CEY Amp-dependent synthetase and ligase FJM75_RS16690 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FJM75_RS16705 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FJM75_RS16715 ENOG4105CGU Enoyl-CoA hydratase FJM75_RS16720 ENOG4105E39 Enoyl-CoA hydratase FJM75_RS16725 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FJM75_RS16730 ENOG4108Z0R Transferase FJM75_RS16735 ENOG4105EA8 2-Nitropropane dioxygenase FJM75_RS16745 ENOG4105C7J ABC transporter, permease FJM75_RS16750 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FJM75_RS16780 ENOG4107QN2 dihydrolipoyl dehydrogenase FJM75_RS16790 ENOG4108UMN azlc family FJM75_RS16800 ENOG410667J hydrolase FJM75_RS16810 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FJM75_RS16820 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FJM75_RS16840 ENOG41068WN FJM75_RS16845 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FJM75_RS16890 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) FJM75_RS16920 ENOG4105CB2 alcohol dehydrogenase FJM75_RS16965 ENOG41068WN FJM75_RS16995 ENOG4105JVQ RNA Polymerase FJM75_RS17000 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FJM75_RS17025 ENOG4105E1K spore germination protein FJM75_RS17035 ENOG4105C75 arginyL-tRNA synthetase FJM75_RS17055 ENOG4105KTU Transcriptional regulator, arsr family FJM75_RS17065 ENOG4105E09 nadh pyrophosphatase FJM75_RS17070 ENOG4107YCR Transcriptional regulator, ARSR family FJM75_RS17075 ENOG4108W6C Dehydrogenase FJM75_RS17080 ENOG4108KF3 Electron transport protein SCO1 SenC FJM75_RS17095 ENOG4108B31 Spore germination protein FJM75_RS17110 ENOG4105WH1 Two component transcriptional regulator luxr family FJM75_RS17115 ENOG4105BZU Histidine kinase FJM75_RS17125 ENOG4107YZX Universal stress protein FJM75_RS17130 ENOG4105VZ8 Transcriptional regulator FJM75_RS17150 ENOG4108W0I acetyltransferase FJM75_RS17160 ENOG4105D6N CoA-transferase, subunit a FJM75_RS17165 ENOG4108IIH CoA-transferase subunit B FJM75_RS17170 ENOG4105CY2 Citrate transporter FJM75_RS17175 ENOG4105DTD Dehydrogenase FJM75_RS17205 ENOG4108J59 Extracellular solute-binding protein, family 5 FJM75_RS17215 ENOG4108SAX Membrane FJM75_RS17225 ENOG4108ZRV stage ii sporulation protein p FJM75_RS17230 ENOG4108JYZ YitT family FJM75_RS17250 ENOG4105C0H protease FJM75_RS17255 ENOG4105EX9 Membrane FJM75_RS17260 ENOG4107YRI Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FJM75_RS17275 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FJM75_RS17285 ENOG4105CNN ABC, transporter FJM75_RS17290 ENOG4105C2J ABC transporter FJM75_RS17295 ENOG4105FCA ABC transporter periplasmic-binding protein YphF FJM75_RS17300 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FJM75_RS17305 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FJM75_RS17310 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FJM75_RS17320 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FJM75_RS17325 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FJM75_RS17330 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FJM75_RS17335 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FJM75_RS17340 ENOG4105VRR gCN5-related N-acetyltransferase FJM75_RS17345 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FJM75_RS17350 ENOG4105BZU Histidine kinase FJM75_RS17395 ENOG4105CVP deoxyribo-dipyrimidine photolyase FJM75_RS17405 ENOG4108B31 Spore germination protein FJM75_RS17415 ENOG4105C84 Histidine ammonia-lyase FJM75_RS17420 ENOG4108ZB6 transcriptional regulator AsnC family FJM75_RS17425 ENOG4105CHM Aminotransferase FJM75_RS17440 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FJM75_RS17445 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FJM75_RS17450 ENOG4105BZN citrate synthase FJM75_RS17490 ENOG4105KPY Small multidrug resistance protein FJM75_RS17495 ENOG4105C5H ABC transporter FJM75_RS17500 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FJM75_RS17505 ENOG4105BZU Histidine kinase FJM75_RS17510 ENOG4105HNY Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FJM75_RS17515 ENOG4105BZU Histidine kinase FJM75_RS17525 ENOG4105BZU Histidine kinase FJM75_RS17585 ENOG4107T5V SNARE associated Golgi FJM75_RS17605 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FJM75_RS17610 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FJM75_RS17635 ENOG4105CHR reductase FJM75_RS17645 ENOG41066HZ AIG2-like family FJM75_RS17655 ENOG4108Z4K mutator MutT protein FJM75_RS17675 ENOG4105E2K Glycosyl transferase (Group 1 FJM75_RS17695 ENOG4105VZ8 Transcriptional regulator FJM75_RS17710 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FJM75_RS17715 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FJM75_RS17730 ENOG41088CQ domain protein FJM75_RS17745 ENOG4108ZHJ Organic hydroperoxide resistance protein FJM75_RS17750 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein FJM75_RS17785 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FJM75_RS17790 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) FJM75_RS17795 ENOG4105ETE Transcriptional regulator (LacI family FJM75_RS17800 ENOG4108RVA ribokinase FJM75_RS17805 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FJM75_RS17810 ENOG4105C2J ABC transporter FJM75_RS17815 ENOG4105CNN ABC, transporter FJM75_RS17820 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FJM75_RS17825 ENOG4105CRN Aminoglycoside phosphotransferase FJM75_RS17830 ENOG4105CPC Aldo Keto reductase FJM75_RS17870 ENOG4105C0R drug resistance transporter emrb qaca subfamily FJM75_RS17890 ENOG4105VEQ Cold shock protein FJM75_RS17905 ENOG4105CMT Dihydroxyacetone kinase FJM75_RS17915 ENOG4105VDH Dihydroxyacetone kinase FJM75_RS17920 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FJM75_RS17925 ENOG41067SE Tetr family transcriptional regulator FJM75_RS17935 ENOG4105C5X domain protein FJM75_RS17940 ENOG4105DXB Major Facilitator superfamily FJM75_RS17955 ENOG4105D5U fad dependent oxidoreductase FJM75_RS17960 ENOG4108SA1 esterase FJM75_RS17970 ENOG4105EMN RNA polymerase sigma factor FJM75_RS17990 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FJM75_RS17995 ENOG4107YHD transcriptional regulator FJM75_RS18005 ENOG4105C26 Dehydrogenase FJM75_RS18015 ENOG4105BZU Histidine kinase FJM75_RS18020 ENOG4105KK4 UPF0060 membrane protein FJM75_RS18025 ENOG4108I0C methyltransferase FJM75_RS18030 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FJM75_RS18035 ENOG4107TS3 membrane protein, TerC FJM75_RS18045 ENOG4105CUT histidyl-tRNA synthetase FJM75_RS18060 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FJM75_RS18075 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FJM75_RS18080 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FJM75_RS18115 ENOG4108UXE Protein tyrosine phosphatase FJM75_RS18120 ENOG4107R5R arsenical pump membrane protein FJM75_RS18135 ENOG4107R0W ABC transporter FJM75_RS18140 ENOG4105E5Q amino acid AbC transporter FJM75_RS18145 ENOG4105CDA abc transporter atp-binding protein FJM75_RS18150 ENOG4105C31 Tryptophanyl-tRNA synthetase FJM75_RS18155 ENOG4105BZU Histidine kinase FJM75_RS18160 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FJM75_RS18165 ENOG4105BZU Histidine kinase FJM75_RS18175 ENOG4105C94 Transporter FJM75_RS18180 ENOG4105EC3 peptidase S51, dipeptidase E FJM75_RS18195 ENOG4105KVH Transcriptional regulator FJM75_RS18200 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FJM75_RS18210 ENOG4105F27 Major Facilitator FJM75_RS18220 ENOG4108JUB Transcriptional regulator FJM75_RS18220 ENOG4108JUB Transcriptional regulator FJM75_RS18225 ENOG4105CSX c4-dicarboxylate anaerobic carrier FJM75_RS18230 ENOG4105DYB Isoaspartyl dipeptidase FJM75_RS18250 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FJM75_RS18270 ENOG4107Y2X deaminase FJM75_RS18275 ENOG4107SVH Potassium channel protein FJM75_RS18280 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FJM75_RS18300 ENOG4105G0J serine threonine protein kinase FJM75_RS18310 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FJM75_RS18325 ENOG4108HKT sucrose-6-phosphate hydrolase FJM75_RS18335 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FJM75_RS18340 ENOG4107RVG penicillin-binding protein FJM75_RS18350 ENOG41068WN FJM75_RS18375 ENOG4107RUZ Sss sodium solute transporter superfamily FJM75_RS18385 ENOG41075H3 AraC family transcriptional regulator FJM75_RS18395 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FJM75_RS18400 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FJM75_RS18405 ENOG4107QN1 sodium solute FJM75_RS18410 ENOG4105BZU Histidine kinase FJM75_RS18415 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FJM75_RS18420 ENOG4105C5A transporter FJM75_RS18425 ENOG4105P4J Allophanate hydrolase, subunit 1 FJM75_RS18430 ENOG4105E7W lamb ycsf family protein FJM75_RS18445 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FJM75_RS18450 ENOG4105CFM UPF0317 protein FJM75_RS18515 ENOG41080TC multidrug resistance protein FJM75_RS18520 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FJM75_RS18590 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FJM75_RS18640 ENOG4105DCF alanine dehydrogenase FJM75_RS18645 ENOG4108K8K Transcriptional regulator FJM75_RS18685 ENOG4108MRH transcriptional regulatory protein FJM75_RS18700 ENOG41088CC tellurite resistance protein tehB FJM75_RS18705 ENOG4105RHY Pfam:UPF0157 FJM75_RS18715 ENOG4105E0M Sulfatase FJM75_RS18740 ENOG4105NF4 modulator of drug activity FJM75_RS18785 ENOG4108QTI )-transporter FJM75_RS18795 ENOG4108428 Inherit from COG: -acetyltransferase FJM75_RS18800 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FJM75_RS18805 ENOG4105CSC Glucose uptake protein FJM75_RS18810 ENOG4108HGU Histidine kinase FJM75_RS18825 ENOG4107BMA Transglycosylase associated protein FJM75_RS18830 ENOG4106SCS STAS domain FJM75_RS18840 ENOG4108PSK reductase FJM75_RS18850 ENOG4105CH6 catalase FJM75_RS18875 ENOG4105C7N Xanthine uracil vitamin C permease FJM75_RS18885 ENOG4105C5F glutamine synthetase FJM75_RS18890 ENOG4108V5C ABC transporter FJM75_RS18895 ENOG4105DQ5 transport system permease protein FJM75_RS18900 ENOG4105EHG Permease protein FJM75_RS18910 ENOG4105E0A ABC, transporter FJM75_RS18920 ENOG4105CPC Aldo Keto reductase FJM75_RS18935 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FJM75_RS18995 ENOG4105G6Z alkaline phosphatase FJM75_RS19005 ENOG4105EE0 oxidoreductase FJM75_RS19020 ENOG4105CPQ Dehydrogenase FJM75_RS19030 ENOG4105CY2 Citrate transporter FJM75_RS19035 ENOG4105DTD Dehydrogenase FJM75_RS19060 ENOG4105EMU Dehydrogenase FJM75_RS19090 ENOG4105NF4 modulator of drug activity FJM75_RS19095 ENOG4105CV8 reductase FJM75_RS19135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FJM75_RS19140 ENOG4105GR3 Histidine kinase FJM75_RS19155 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FJM75_RS19190 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FJM75_RS19195 ENOG4105C2C drug resistance transporter, Bcr CflA FJM75_RS19200 ENOG4105BZ1 (ABC) transporter FJM75_RS19230 ENOG4105C0D helicase FJM75_RS19235 ENOG4107TUM Amidinotransferase FJM75_RS19285 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FJM75_RS19290 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FJM75_RS19300 ENOG4105DAP Nicotinate phosphoribosyltransferase FJM75_RS19305 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FJM75_RS19310 ENOG4108QY0 Membrane FJM75_RS19320 ENOG410751J FJM75_RS19330 ENOG41068WN FJM75_RS19360 ENOG41068JE domain protein FJM75_RS19395 ENOG4105E90 ABC transporter FJM75_RS19400 ENOG4108IJ8 ABC transporter FJM75_RS19405 ENOG4105E90 ABC transporter FJM75_RS19445 ENOG4105VMP Transcriptional regulator FJM75_RS19455 ENOG4105KNA -acetyltransferase FJM75_RS19480 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FJM75_RS19490 ENOG4105CHP RNA polymerase FJM75_RS19530 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FJM75_RS19535 ENOG4108VX5 3-methyladenine DNA glycosylase FJM75_RS19555 ENOG4107STQ Multicopper oxidase FJM75_RS19590 ENOG4107RUZ Sss sodium solute transporter superfamily FJM75_RS19595 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FJM75_RS19605 ENOG4105C26 Dehydrogenase FJM75_RS19660 ENOG4108IJ0 Aspartate ammonia-lyase FJM75_RS19665 ENOG4108JE9 extracellular solute-binding protein family 1 FJM75_RS19675 ENOG4105DRS transport system, permease FJM75_RS19680 ENOG4105ETE Transcriptional regulator (LacI family FJM75_RS19690 ENOG4105E90 ABC transporter FJM75_RS19695 ENOG4108IJ8 ABC transporter FJM75_RS19700 ENOG4105E90 ABC transporter FJM75_RS19715 ENOG4105DM4 PTS System FJM75_RS19720 ENOG4105C8I hydrolase, family 38 FJM75_RS19730 ENOG4105BZW Glycerate kinase FJM75_RS19735 ENOG4108U7W acetyltransferase FJM75_RS19745 ENOG4107ZYR domain protein FJM75_RS19750 ENOG4105CZN Potassium uptake protein FJM75_RS19775 ENOG41069JR FJM75_RS19780 ENOG4105DA5 (ABC) transporter FJM75_RS19795 ENOG4107RJ1 sodium solute FJM75_RS19800 ENOG4105ETE Transcriptional regulator (LacI family FJM75_RS19805 ENOG4105CHR reductase FJM75_RS19815 ENOG4105C0A alcohol dehydrogenase FJM75_RS19855 ENOG4108JUB Transcriptional regulator FJM75_RS19860 ENOG4105C0A alcohol dehydrogenase FJM75_RS19865 ENOG4105CY2 Citrate transporter FJM75_RS19870 ENOG4105C26 Dehydrogenase FJM75_RS19915 ENOG4105C4R Atp-dependent dna helicase FJM75_RS19935 ENOG4105DVF Cytosine-specific methyltransferase FJM75_RS19950 ENOG4108HFV FJM75_RS19975 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FJM75_RS19985 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FJM75_RS20005 ENOG4105EW6 flavin reductase domain protein, FMN-binding FJM75_RS20010 ENOG4105C4R Atp-dependent dna helicase FJM75_RS20015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FJM75_RS20085 ENOG4106ANW SMI1_KNR4 FJM75_RS20130 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) FJM75_RS20160 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FJM75_RS20210 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FJM75_RS20215 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FJM75_RS20220 ENOG4105BZU Histidine kinase FJM75_RS20230 ENOG4105CJ1 ABC, transporter FJM75_RS20260 ENOG4108QY0 Membrane FJM75_RS20280 ENOG4108HVR ABC transporter, permease FJM75_RS20285 ENOG4105C19 ABC transporter FJM75_RS20290 ENOG4105EWM Histidine kinase FJM75_RS20295 ENOG4105CJZ response regulator FJM75_RS20315 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FJM75_RS20375 ENOG4105EQ2 LysR family Transcriptional regulator FJM75_RS20415 ENOG4105KPY Small multidrug resistance protein FJM75_RS20425 ENOG4105BZU Histidine kinase FJM75_RS20440 ENOG4105C6Z Gluconate FJM75_RS20445 ENOG4105PGM cation diffusion facilitator family transporter FJM75_RS20460 ENOG4108XET gCN5-related N-acetyltransferase FJM75_RS20465 ENOG4108N23 SpoOM-related protein FJM75_RS20510 ENOG4108IUX (ABC) transporter FJM75_RS20565 ENOG41067SE Tetr family transcriptional regulator FJM75_RS20570 ENOG4105C0R drug resistance transporter emrb qaca subfamily FJM75_RS20575 ENOG4108NHD germination protein FJM75_RS20580 ENOG4108Q8B Spore germination protein FJM75_RS20590 ENOG4108IFG nitrite reductase, (NAD(P)H) FJM75_RS20600 ENOG4105EXQ uroporphyrinogen iii synthase hem4 FJM75_RS20645 ENOG4105DKW ABC transporter FJM75_RS20660 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FJM75_RS20665 ENOG4107QHM Sulfite reductase FJM75_RS20700 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FJM75_RS20725 ENOG4105CHH sulfate transporter FJM75_RS20735 ENOG4107QNK )-transporter FJM75_RS20740 ENOG4108WUH Transcriptional regulator, TetR family FJM75_RS20755 ENOG4107TXC Transcriptional regulator FJM75_RS20765 ENOG4108UW5 maltose o-acetyltransferase FJM75_RS20790 ENOG4105DRS transport system, permease FJM75_RS20795 ENOG4105BZU Histidine kinase FJM75_RS20820 ENOG4105D3R alkyl hydroperoxide reductase FJM75_RS20825 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase FJM75_RS20830 ENOG4105CAQ asparagine synthetase FJM75_RS20865 ENOG4105F6S Spore photoproduct lyase FJM75_RS20880 ENOG4108KK1 membrane protein AbrB duplication FJM75_RS20900 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FJM75_RS20925 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FJM75_RS20935 ENOG4105D3R alkyl hydroperoxide reductase FJM75_RS20955 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FJM75_RS20970 ENOG4108JIG Anaerobic dehydrogenase FJM75_RS20975 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FJM75_RS20985 ENOG4105CBD Diacylglycerol kinase FJM75_RS20990 ENOG4105DU0 nucleoside hydrolase FJM75_RS21000 ENOG4105C02 permease FJM75_RS21005 ENOG41069ER domain protein FJM75_RS21030 ENOG4105Q95 Cupin 2, conserved barrel domain protein FJM75_RS21040 ENOG4105C5Y PTS System FJM75_RS21045 ENOG4105CG3 alpha amylase, catalytic region FJM75_RS21050 ENOG4107414 GntR family transcriptional regulator FJM75_RS21060 ENOG4105EA8 2-Nitropropane dioxygenase FJM75_RS21065 ENOG4108JA1 polyketide synthase FJM75_RS21085 ENOG4105C0D helicase FJM75_RS21095 ENOG4105C94 Transporter FJM75_RS21105 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FJM75_RS21110 ENOG4105WQG acetyltransferase FJM75_RS21115 ENOG4108URH decarboxylase FJM75_RS21140 ENOG4105C19 ABC transporter FJM75_RS21145 ENOG4107RBB ABC transporter, permease FJM75_RS21150 ENOG4105C9U ATP-dependent DNA helicase RecQ FJM75_RS21155 ENOG4108QY0 Membrane FJM75_RS21175 ENOG41081WG 50s ribosomal protein l31 FJM75_RS21185 ENOG41067SE Tetr family transcriptional regulator FJM75_RS21210 ENOG4105C3F Signal peptidase i FJM75_RS21215 ENOG4105K4I Scp-like extracellular FJM75_RS21230 ENOG41060AI SEC-C motif FJM75_RS21235 ENOG4105BZU Histidine kinase FJM75_RS21240 ENOG4108KGH TRANSCRIPTIONal FJM75_RS21245 ENOG4107U9T Pfam:Ribonuclease_BN FJM75_RS21250 ENOG4105BZU Histidine kinase FJM75_RS21275 ENOG4107YZX Universal stress protein FJM75_RS21285 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FJM75_RS21295 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FJM75_RS21300 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FJM75_RS21310 ENOG4108SJC Membrane FJM75_RS21320 ENOG4105E1K spore germination protein FJM75_RS21355 ENOG4105BZU Histidine kinase FJM75_RS21365 ENOG4107YZX Universal stress protein FJM75_RS21370 ENOG4105DSE periplasmic solute binding protein FJM75_RS21375 ENOG4105DIK (ABC) transporter FJM75_RS21380 ENOG4105CC5 ABC transporter FJM75_RS21385 ENOG4105CC5 ABC transporter FJM75_RS21390 ENOG4108TM9 integral membrane protein FJM75_RS21395 ENOG4105XXY Thioredoxin FJM75_RS21400 ENOG4105D0M Protease HtpX homolog FJM75_RS21410 ENOG4107QP3 malate synthase g FJM75_RS21420 ENOG4105CYT Selenoprotein B, glycine betaine sarcosine D-proline reductase family FJM75_RS21435 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FJM75_RS21440 ENOG4105BZ4 penicillin-binding protein FJM75_RS21500 ENOG4108XRC Protein of unknown function (DUF458) FJM75_RS21510 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FJM75_RS21515 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FJM75_RS21525 ENOG4105E0M Sulfatase FJM75_RS21535 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein FJM75_RS21540 ENOG4105E5Q amino acid AbC transporter FJM75_RS21545 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FJM75_RS21570 ENOG4105BZU Histidine kinase FJM75_RS21610 ENOG4105WEF catalase FJM75_RS21630 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FJM75_RS21635 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FJM75_RS21645 ENOG4105EYH Exonuclease FJM75_RS21660 ENOG4105ERH Fumarylacetoacetate hydrolase FJM75_RS21665 ENOG4105C26 Dehydrogenase FJM75_RS21670 ENOG4105C8Y Acetylornithine aminotransferase FJM75_RS21680 ENOG4105BZU Histidine kinase FJM75_RS21695 ENOG4105CAQ asparagine synthetase FJM75_RS21705 ENOG4108YZA Nitrogen regulatory protein pii FJM75_RS21715 ENOG4107FKK extracellular solute-binding protein family 1 FJM75_RS21725 ENOG4105EG2 ABC transporter, permease FJM75_RS21735 ENOG4105DQE DNA ligase FJM75_RS21745 ENOG4105FDF Could be involved in DNA repair (By similarity) FJM75_RS21750 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FJM75_RS21755 ENOG4105BZU Histidine kinase FJM75_RS21760 ENOG4105ETU transcriptional activator (TenA FJM75_RS21770 ENOG4108JJB ABC transporter FJM75_RS21785 ENOG4105EPR degv family FJM75_RS21790 ENOG4107AYK membrAne FJM75_RS21825 ENOG4108KP7 hydrolase FJM75_RS21835 ENOG4108MXZ Esterase FJM75_RS21840 ENOG4105VG1 fes assembly suf system protein FJM75_RS21845 ENOG4105VRS hydrolase family 18 FJM75_RS21850 ENOG4105CVM Molybdenum cofactor synthesis domain protein FJM75_RS21855 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FJM75_RS21860 ENOG4108ZAF Molybdopterin FJM75_RS21870 ENOG4107V6Q Cyclic nucleotide-binding domain FJM75_RS21875 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FJM75_RS21890 ENOG4108606 TspO/MBR family FJM75_RS21930 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FJM75_RS21935 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FJM75_RS21945 ENOG4105C31 Tryptophanyl-tRNA synthetase FJM75_RS21955 ENOG4107QSI ABC, transporter FJM75_RS21960 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FJM75_RS21965 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FJM75_RS21975 ENOG4108JQ7 (ABC) transporter