locus-tag	class	description
CU648_RS00005	COG0697	spore germination
CU648_RS00010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_RS00050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_RS00065	COG2959	enzyme of heme biosynthesis
CU648_RS00090	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CU648_RS00100	COG1309	transcriptional regulator
CU648_RS00135	COG3284	Transcriptional regulator
CU648_RS00150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_RS00155	COG1349	DNA-binding transcription factor activity
CU648_RS00175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU648_RS00190	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU648_RS00195	COG0022	dehydrogenase e1 component
CU648_RS00200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU648_RS00210	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS00215	COG0456	acetyltransferase
CU648_RS00215	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU648_RS00255	COG4176	ABC-type proline glycine betaine transport system permease component
CU648_RS00260	COG0517	IMP dehydrogenase activity
CU648_RS00260	COG4175	Glycine betaine
CU648_RS00290	COG2153	protein acetylation
CU648_RS00295	COG3397	chitin binding
CU648_RS00310	COG2205	protein histidine kinase activity
CU648_RS00320	COG2315	Protein conserved in bacteria
CU648_RS00330	COG0658	competence protein
CU648_RS00330	COG2333	competence protein COMEC
CU648_RS00380	COG3973	AAA domain
CU648_RS00400	COG0514	ATP-dependent DNA helicase (RecQ)
CU648_RS00435	COG4637	Psort location Cytoplasmic, score
CU648_RS00455	COG3397	chitin binding
CU648_RS00470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU648_RS00475	COG1115	amino acid carrier protein
CU648_RS00480	COG1012	belongs to the aldehyde dehydrogenase family
CU648_RS00485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU648_RS00495	COG3938	Belongs to the proline racemase family
CU648_RS00500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU648_RS00540	COG0586	Pfam SNARE associated Golgi protein
CU648_RS00555	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CU648_RS00560	COG0519	Catalyzes the synthesis of GMP from XMP
CU648_RS00565	COG4166	transmembrane transport
CU648_RS00575	COG4948	Mandelate Racemase Muconate Lactonizing
CU648_RS00620	COG2936	dipeptidyl-peptidase activity
CU648_RS00625	COG5002	protein histidine kinase activity
CU648_RS00630	COG0745	RESPONSE REGULATOR receiver
CU648_RS00660	COG1164	Oligoendopeptidase f
CU648_RS00665	COG0531	amino acid
CU648_RS00670	COG1522	sequence-specific DNA binding
CU648_RS00675	COG1307	EDD domain protein, DegV family
CU648_RS00715	COG2814	Major facilitator Superfamily
CU648_RS00725	COG1664	Polymer-forming cytoskeletal
CU648_RS00730	COG0789	Transcriptional regulator
CU648_RS00735	COG4533	DNA binding
CU648_RS00740	COG2814	Major facilitator Superfamily
CU648_RS00740	COG0477	Major facilitator Superfamily
CU648_RS00760	COG2261	transglycosylase associated protein
CU648_RS00775	COG2226	methyltransferase
CU648_RS00815	COG0436	Aminotransferase
CU648_RS00820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CU648_RS00825	COG5146	pantothenate kinase activity
CU648_RS00830	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CU648_RS00850	COG1131	(ABC) transporter
CU648_RS00910	COG0628	permease
CU648_RS00925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU648_RS00930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU648_RS00935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU648_RS00960	COG2816	NAD+ diphosphatase activity
CU648_RS00980	COG2746	aminoglycoside 3-N-acetyltransferase activity
CU648_RS01010	COG0697	spore germination
CU648_RS01015	COG2318	DinB family
CU648_RS01035	COG4912	Dna alkylation repair
CU648_RS01060	COG0861	Integral membrane protein TerC family
CU648_RS01065	COG1368	sulfuric ester hydrolase activity
CU648_RS01075	COG0488	(ABC) transporter
CU648_RS01085	COG2409	Drug exporters of the RND superfamily
CU648_RS01085	COG1033	growth of symbiont in host cell
CU648_RS01090	COG1309	transcriptional regulator
CU648_RS01105	COG0287	Prephenate dehydrogenase
CU648_RS01110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU648_RS01125	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CU648_RS01125	COG1605	Chorismate mutase
CU648_RS01165	COG3584	3D domain protein
CU648_RS01165	COG1388	LysM domain
CU648_RS01180	COG1595	DNA-templated transcription, initiation
CU648_RS01205	COG1879	ABC-type sugar transport system periplasmic component
CU648_RS01215	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU648_RS01225	COG2390	Transcriptional regulator
CU648_RS01230	COG1070	Carbohydrate kinase
CU648_RS01265	COG2329	Antibiotic biosynthesis monooxygenase
CU648_RS01285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_RS01295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CU648_RS01305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU648_RS01310	COG4187	Peptidase family M20/M25/M40
CU648_RS01315	COG1414	Transcriptional regulator
CU648_RS01325	COG0833	amino acid
CU648_RS01345	COG1690	Belongs to the RtcB family
CU648_RS01350	COG3239	Fatty acid desaturase
CU648_RS01355	COG1785	Belongs to the alkaline phosphatase family
CU648_RS01365	COG3655	Transcriptional regulator
CU648_RS01380	COG4377	Putative membrane peptidase family (DUF2324)
CU648_RS01390	COG3279	Response regulator of the LytR AlgR family
CU648_RS01410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_RS01415	COG0346	lactoylglutathione lyase activity
CU648_RS01440	COG0714	Associated with various cellular activities
CU648_RS01465	COG0463	Glycosyl transferase, family 2
CU648_RS01485	COG0463	Glycosyl transferase, family 2
CU648_RS01495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU648_RS01500	COG0753	catalase activity
CU648_RS01510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CU648_RS01535	COG0714	Associated with various cellular activities
CU648_RS01545	COG0778	Nitroreductase
CU648_RS01550	COG1846	Transcriptional regulator
CU648_RS01590	COG1725	Transcriptional regulator
CU648_RS01610	COG1136	(ABC) transporter
CU648_RS01635	COG2207	Transcriptional regulator
CU648_RS01640	COG0456	acetyltransferase
CU648_RS01660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_RS01710	COG0730	response to heat
CU648_RS01720	COG0833	amino acid
CU648_RS01730	COG4335	DNA alkylation repair
CU648_RS01760	COG0768	penicillin binding
CU648_RS01795	COG1984	allophanate hydrolase subunit 2
CU648_RS01800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CU648_RS01805	COG1414	Transcriptional regulator
CU648_RS01830	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU648_RS01840	COG0640	Transcriptional regulator
CU648_RS01850	COG1960	acyl-CoA dehydrogenase activity
CU648_RS01865	COG3314	Sporulation integral membrane protein YlbJ
CU648_RS01895	COG3848	Pyruvate phosphate dikinase
CU648_RS01895	COG0574	Belongs to the PEP-utilizing enzyme family
CU648_RS01905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS01920	COG5577	PFAM Coat F domain
CU648_RS01930	COG3403	YqcI/YcgG family
CU648_RS01935	COG1280	lysine exporter protein (LysE YggA)
CU648_RS01940	COG1113	amino acid transport
CU648_RS01975	COG1063	alcohol dehydrogenase
CU648_RS01990	COG4977	sequence-specific DNA binding
CU648_RS02005	COG4974	Belongs to the 'phage' integrase family
CU648_RS02020	COG1335	isochorismatase
CU648_RS02025	COG0431	NADPH-dependent FMN reductase
CU648_RS02070	COG0210	DNA helicase
CU648_RS02075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CU648_RS02085	COG0737	Belongs to the 5'-nucleotidase family
CU648_RS02090	COG0753	catalase activity
CU648_RS02095	COG0598	Magnesium transport protein CorA
CU648_RS02140	COG0415	Belongs to the DNA photolyase family
CU648_RS02145	COG0288	reversible hydration of carbon dioxide
CU648_RS02155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CU648_RS02160	COG5609	conserved protein (DUF2294)
CU648_RS02175	COG0714	Associated with various cellular activities
CU648_RS02185	COG1575	Belongs to the MenA family. Type 1 subfamily
CU648_RS02190	COG2267	carboxylic ester hydrolase activity
CU648_RS02200	COG0803	Belongs to the bacterial solute-binding protein 9 family
CU648_RS02205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU648_RS02210	COG1121	(ABC) transporter
CU648_RS02240	COG0798	PFAM Bile acid sodium symporter
CU648_RS02245	COG0346	lactoylglutathione lyase activity
CU648_RS02250	COG0640	Transcriptional regulator
CU648_RS02265	COG0443	Heat shock 70 kDa protein
CU648_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS02280	COG1522	sequence-specific DNA binding
CU648_RS02295	COG0346	lactoylglutathione lyase activity
CU648_RS02340	COG2814	Major facilitator Superfamily
CU648_RS02370	COG0745	RESPONSE REGULATOR receiver
CU648_RS02375	COG5002	protein histidine kinase activity
CU648_RS02375	COG3850	Histidine kinase
CU648_RS02410	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CU648_RS02435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS02440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU648_RS02450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_RS02465	COG2309	aminopeptidase activity
CU648_RS02480	COG0789	Transcriptional regulator
CU648_RS02485	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU648_RS02505	COG0577	efflux transmembrane transporter activity
CU648_RS02520	COG5002	protein histidine kinase activity
CU648_RS02520	COG3850	Histidine kinase
CU648_RS02530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS02550	COG1619	proteins homologs of microcin C7 resistance protein MccF
CU648_RS02565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CU648_RS02585	COG1595	DNA-templated transcription, initiation
CU648_RS02600	COG0662	Cupin 2, conserved barrel domain protein
CU648_RS02610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_RS02610	COG2207	Transcriptional regulator
CU648_RS02640	COG5632	N-Acetylmuramoyl-L-alanine amidase
CU648_RS02640	COG3409	Peptidoglycan-binding domain 1 protein
CU648_RS02655	COG2814	Major facilitator Superfamily
CU648_RS02695	COG0477	Major facilitator Superfamily
CU648_RS02705	COG1846	Transcriptional regulator
CU648_RS02710	COG2814	Major facilitator Superfamily
CU648_RS02725	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CU648_RS02730	COG1131	(ABC) transporter
CU648_RS02750	COG2076	Multidrug Resistance protein
CU648_RS02755	COG1309	transcriptional regulator
CU648_RS02765	COG2031	fatty acid transporter
CU648_RS02805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CU648_RS02820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU648_RS02825	COG1288	antiporter activity
CU648_RS02840	COG2814	Major facilitator Superfamily
CU648_RS02845	COG1309	transcriptional regulator
CU648_RS02850	COG0789	Transcriptional regulator
CU648_RS02875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CU648_RS02900	COG1733	regulation of RNA biosynthetic process
CU648_RS02905	COG0778	Nitroreductase
CU648_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS02940	COG1131	(ABC) transporter
CU648_RS02965	COG1011	Hydrolase
CU648_RS02975	COG2365	Tyrosine phosphatase family
CU648_RS02995	COG0346	lactoylglutathione lyase activity
CU648_RS03000	COG1940	carbohydrate kinase activity
CU648_RS03005	COG0738	Major facilitator superfamily
CU648_RS03010	COG0110	maltose O-acetyltransferase activity
CU648_RS03025	COG0628	permease
CU648_RS03045	COG2226	methyltransferase
CU648_RS03055	COG0477	Major facilitator Superfamily
CU648_RS03085	COG1253	flavin adenine dinucleotide binding
CU648_RS03090	COG0789	Transcriptional regulator
CU648_RS03095	COG0697	spore germination
CU648_RS03100	COG1357	PFAM Pentapeptide repeats (8 copies)
CU648_RS03105	COG3813	Protein conserved in bacteria
CU648_RS03115	COG2706	6-phosphogluconolactonase activity
CU648_RS03120	COG1070	Carbohydrate kinase
CU648_RS03130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CU648_RS03135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CU648_RS03145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CU648_RS03155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU648_RS03175	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS03195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU648_RS03195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU648_RS03200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU648_RS03200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU648_RS03205	COG1733	regulation of RNA biosynthetic process
CU648_RS03240	COG0814	amino acid
CU648_RS03270	COG1393	Belongs to the ArsC family
CU648_RS03280	COG2188	Transcriptional regulator
CU648_RS03285	COG0673	inositol 2-dehydrogenase activity
CU648_RS03290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU648_RS03295	COG1733	regulation of RNA biosynthetic process
CU648_RS03300	COG1733	regulation of RNA biosynthetic process
CU648_RS03320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS03340	COG0384	phenazine biosynthesis protein PhzF
CU648_RS03355	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_RS03360	COG2249	NAD(P)H dehydrogenase (quinone) activity
CU648_RS03365	COG1733	regulation of RNA biosynthetic process
CU648_RS03385	COG1191	sigma factor activity
CU648_RS03405	COG1309	transcriptional regulator
CU648_RS03435	COG3152	Membrane
CU648_RS03465	COG1151	hydroxylamine reductase activity
CU648_RS03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS03485	COG3409	Peptidoglycan-binding domain 1 protein
CU648_RS03485	COG3757	hydrolase, family 25
CU648_RS03520	COG2072	flavoprotein involved in K transport
CU648_RS03560	COG1113	amino acid transport
CU648_RS03580	COG2814	Major facilitator Superfamily
CU648_RS03615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU648_RS03620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CU648_RS03635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_RS03640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS03645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS03650	COG3739	integral membrane protein
CU648_RS03655	COG0384	phenazine biosynthesis protein PhzF
CU648_RS03675	COG0583	DNA-binding transcription factor activity
CU648_RS03695	COG1193	negative regulation of DNA recombination
CU648_RS03710	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CU648_RS03715	COG1164	Oligoendopeptidase f
CU648_RS03720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU648_RS03750	COG0584	glycerophosphoryl diester phosphodiesterase
CU648_RS03775	COG0640	Transcriptional regulator
CU648_RS03780	COG0604	alcohol dehydrogenase
CU648_RS03800	COG0457	Tetratricopeptide repeat
CU648_RS03810	COG0385	Bile acid
CU648_RS03815	COG0277	FAD linked oxidase domain protein
CU648_RS03855	COG1216	Glycosyl transferase, family 2
CU648_RS03860	COG1024	Enoyl-CoA hydratase
CU648_RS03870	COG1285	pathogenesis
CU648_RS03885	COG2514	catechol 2,3-dioxygenase activity
CU648_RS03890	COG2720	vancomycin resistance protein
CU648_RS03930	COG0716	FMN binding
CU648_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS03970	COG0165	Argininosuccinate lyase
CU648_RS03985	COG4145	pantothenate transmembrane transporter activity
CU648_RS03995	COG1012	belongs to the aldehyde dehydrogenase family
CU648_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS04015	COG1657	PFAM Prenyltransferase squalene oxidase
CU648_RS04020	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CU648_RS04025	COG2962	Rard protein
CU648_RS04030	COG3326	Membrane
CU648_RS04045	COG0489	protein tyrosine kinase activity
CU648_RS04055	COG0314	molybdopterin synthase activity
CU648_RS04060	COG0303	'Molybdopterin
CU648_RS04065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU648_RS04070	COG2116	formate transmembrane transporter activity
CU648_RS04085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CU648_RS04090	COG5609	conserved protein (DUF2294)
CU648_RS04095	COG2427	Protein of unknown function (DUF1641)
CU648_RS04100	COG3383	formate dehydrogenase (NAD+) activity
CU648_RS04115	COG0697	spore germination
CU648_RS04155	COG2226	methyltransferase
CU648_RS04160	COG4166	transmembrane transport
CU648_RS04165	COG4166	transmembrane transport
CU648_RS04170	COG4166	transmembrane transport
CU648_RS04175	COG1301	dicarboxylic acid transport
CU648_RS04180	COG1316	TRANSCRIPTIONal
CU648_RS04190	COG1595	DNA-templated transcription, initiation
CU648_RS04215	COG1131	(ABC) transporter
CU648_RS04240	COG0673	inositol 2-dehydrogenase activity
CU648_RS04245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU648_RS04250	COG0187	DNA topoisomerase II activity
CU648_RS04260	COG1832	CoA-binding protein
CU648_RS04265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU648_RS04270	COG0745	RESPONSE REGULATOR receiver
CU648_RS04290	COG4841	protein insertion into membrane
CU648_RS04295	COG0824	Thioesterase
CU648_RS04330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_RS04345	COG1132	(ABC) transporter
CU648_RS04350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CU648_RS04390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CU648_RS04405	COG0183	Belongs to the thiolase family
CU648_RS04410	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_RS04415	COG1268	BioY protein
CU648_RS04420	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_RS04475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS04485	COG5002	protein histidine kinase activity
CU648_RS04490	COG0400	carboxylic ester hydrolase activity
CU648_RS04495	COG0346	lactoylglutathione lyase activity
CU648_RS04500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU648_RS04505	COG0069	glutamate synthase activity
CU648_RS04510	COG1902	pentaerythritol trinitrate reductase activity
CU648_RS04515	COG1329	Transcriptional regulator
CU648_RS04520	COG0010	Belongs to the arginase family
CU648_RS04545	COG2226	methyltransferase
CU648_RS04590	COG4846	Membrane protein involved in cytochrome C biogenesis
CU648_RS04595	COG0785	Cytochrome C biogenesis protein
CU648_RS04610	COG1473	amidohydrolase
CU648_RS04620	COG1131	(ABC) transporter
CU648_RS04630	COG0583	DNA-binding transcription factor activity
CU648_RS04640	COG1346	cytolysis
CU648_RS04655	COG0730	response to heat
CU648_RS04670	COG5632	N-Acetylmuramoyl-L-alanine amidase
CU648_RS04670	COG3409	Peptidoglycan-binding domain 1 protein
CU648_RS04685	COG1132	(ABC) transporter
CU648_RS04690	COG1132	(ABC) transporter
CU648_RS04715	COG3639	organic phosphonate transmembrane transporter activity
CU648_RS04730	COG0737	Belongs to the 5'-nucleotidase family
CU648_RS04740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CU648_RS04760	COG1695	Transcriptional regulator
CU648_RS04775	COG5444	nuclease activity
CU648_RS04790	COG0174	glutamine synthetase
CU648_RS04795	COG0789	Transcriptional regulator
CU648_RS04800	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CU648_RS04805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CU648_RS04810	COG2860	membrane
CU648_RS04815	COG0464	growth
CU648_RS04845	COG3584	3D domain protein
CU648_RS04845	COG1388	LysM domain
CU648_RS04855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU648_RS04855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU648_RS04855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU648_RS04860	COG1105	Belongs to the carbohydrate kinase PfkB family
CU648_RS04865	COG1349	DNA-binding transcription factor activity
CU648_RS04870	COG1979	alcohol dehydrogenase
CU648_RS04875	COG2322	membrane
CU648_RS04890	COG1113	amino acid transport
CU648_RS04910	COG1408	metallophosphoesterase
CU648_RS04915	COG2116	formate transmembrane transporter activity
CU648_RS04930	COG2217	Heavy metal translocating P-type atpase
CU648_RS04935	COG2608	mercury ion transmembrane transporter activity
CU648_RS04940	COG1937	Protein conserved in bacteria
CU648_RS04950	COG2819	hydrolase of the alpha beta superfamily
CU648_RS04955	COG1120	ATPase activity
CU648_RS04960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS04965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS04970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_RS04975	COG0708	Exodeoxyribonuclease III
CU648_RS04980	COG2169	Transcriptional regulator
CU648_RS04985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CU648_RS04990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CU648_RS05000	COG2364	Membrane
CU648_RS05015	COG2267	carboxylic ester hydrolase activity
CU648_RS05020	COG0346	lactoylglutathione lyase activity
CU648_RS05025	COG5001	Diguanylate cyclase
CU648_RS05025	COG3300	MHYT domain
CU648_RS05045	COG1346	cytolysis
CU648_RS05050	COG1380	Effector of murein hydrolase LrgA
CU648_RS05055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_RS05060	COG0596	Alpha beta hydrolase
CU648_RS05060	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU648_RS05065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU648_RS05085	COG1404	Belongs to the peptidase S8 family
CU648_RS05090	COG3773	Cell wall hydrolase
CU648_RS05105	COG1368	sulfuric ester hydrolase activity
CU648_RS05110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CU648_RS05140	COG1131	(ABC) transporter
CU648_RS05160	COG4550	Control of competence regulator ComK, YlbF/YmcA
CU648_RS05170	COG1013	pyruvate-flavodoxin oxidoreductase activity
CU648_RS05175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CU648_RS05175	COG0674	pyruvate-flavodoxin oxidoreductase activity
CU648_RS05185	COG2359	stage V sporulation protein S
CU648_RS05190	COG1692	metallophosphoesterase
CU648_RS05215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CU648_RS05220	COG1426	Protein conserved in bacteria
CU648_RS05235	COG0300	oxidoreductase activity
CU648_RS05240	COG0612	Peptidase, M16
CU648_RS05245	COG0612	Peptidase, M16
CU648_RS05250	COG1079	Belongs to the binding-protein-dependent transport system permease family
CU648_RS05255	COG4603	Belongs to the binding-protein-dependent transport system permease family
CU648_RS05260	COG3845	ABC transporter
CU648_RS05265	COG1744	ABC transporter substrate-binding protein PnrA-like
CU648_RS05270	COG2188	Transcriptional regulator
CU648_RS05275	COG1674	ftsk spoiiie
CU648_RS05285	COG0740	serine-type endopeptidase activity
CU648_RS05290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU648_RS05305	COG0527	aspartate kinase activity
CU648_RS05310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CU648_RS05315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CU648_RS05320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CU648_RS05330	COG1873	PFAM PRC-barrel domain
CU648_RS05335	COG0612	Peptidase, M16
CU648_RS05340	COG0726	polysaccharide deacetylase
CU648_RS05355	COG0196	riboflavin kinase activity
CU648_RS05360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CU648_RS05370	COG1550	Protein conserved in bacteria
CU648_RS05380	COG1358	cellular component organization or biogenesis
CU648_RS05385	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CU648_RS05390	COG0195	Participates in both transcription termination and antitermination
CU648_RS05415	COG0750	zinc metalloprotease
CU648_RS05425	COG4589	Belongs to the CDS family
CU648_RS05440	COG0528	UMP kinase activity
CU648_RS05470	COG4974	Belongs to the 'phage' integrase family
CU648_RS05480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CU648_RS05485	COG0758	DNA mediated transformation
CU648_RS05490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CU648_RS05530	COG1837	Belongs to the UPF0109 family
CU648_RS05540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CU648_RS05550	COG0552	protein localization to endoplasmic reticulum
CU648_RS05555	COG1196	nuclear chromosome segregation
CU648_RS05565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CU648_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS05575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CU648_RS05590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CU648_RS05595	COG1461	Dihydroxyacetone kinase
CU648_RS05600	COG1302	Protein conserved in bacteria
CU648_RS05615	COG1564	THIamine pyrophosphokinase
CU648_RS05620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CU648_RS05625	COG1162	GTPase activity
CU648_RS05630	COG0515	serine threonine protein kinase
CU648_RS05630	COG2815	serine threonine protein kinase
CU648_RS05635	COG0631	protein serine/threonine phosphatase activity
CU648_RS05645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CU648_RS05645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CU648_RS05655	COG0242	peptide deformylase activity
CU648_RS05660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CU648_RS05665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CU648_RS05685	COG1561	YicC-like family, N-terminal region
CU648_RS05690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU648_RS05700	COG0006	proline dipeptidase activity
CU648_RS05720	COG3069	C4-dicarboxylate transmembrane transporter activity
CU648_RS05785	COG0564	pseudouridine synthase activity
CU648_RS05805	COG3599	regulation of cell shape
CU648_RS05810	COG2302	S4 RNA-binding domain
CU648_RS05815	COG0762	integral membrane protein
CU648_RS05825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CU648_RS05830	COG1496	oxidoreductase activity
CU648_RS05835	COG1873	PFAM PRC-barrel domain
CU648_RS05840	COG1191	sigma factor activity
CU648_RS05845	COG1191	sigma factor activity
CU648_RS05855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CU648_RS05860	COG0849	cell division
CU648_RS05865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CU648_RS05880	COG0772	Belongs to the SEDS family
CU648_RS05895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CU648_RS05900	COG0768	penicillin binding
CU648_RS05905	COG0768	penicillin binding
CU648_RS05910	COG4839	cell division protein FtsL
CU648_RS05925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CU648_RS05940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CU648_RS05945	COG1399	metal-binding, possibly nucleic acid-binding protein
CU648_RS05955	COG3480	Lon protease (S16) C-terminal proteolytic domain
CU648_RS05960	COG1752	Esterase of the alpha-beta hydrolase superfamily
CU648_RS05965	COG3314	Sporulation integral membrane protein YlbJ
CU648_RS05975	COG0742	ribosomal rna small subunit methyltransferase
CU648_RS05990	COG3679	Belongs to the UPF0342 family
CU648_RS05995	COG0406	alpha-ribazole phosphatase activity
CU648_RS06010	COG2340	Cysteine-rich secretory protein family
CU648_RS06025	COG3344	reverse transcriptase
CU648_RS06035	COG3336	cytochrome c oxidase
CU648_RS06070	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CU648_RS06080	COG0772	Belongs to the SEDS family
CU648_RS06090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CU648_RS06095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CU648_RS06105	COG4896	Protein conserved in bacteria
CU648_RS06120	COG1217	gtp-binding protein TYPA
CU648_RS06130	COG0483	inositol monophosphate 1-phosphatase activity
CU648_RS06150	COG1982	Orn Lys Arg decarboxylase major
CU648_RS06200	COG0022	dehydrogenase e1 component
CU648_RS06205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU648_RS06215	COG0242	peptide deformylase activity
CU648_RS06220	COG0561	phosphatase activity
CU648_RS06235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU648_RS06240	COG0569	domain protein
CU648_RS06260	COG0583	DNA-binding transcription factor activity
CU648_RS06265	COG0517	IMP dehydrogenase activity
CU648_RS06275	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CU648_RS06290	COG4703	Protein of unknown function (DUF1797)
CU648_RS06305	COG2200	EAL domain
CU648_RS06310	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS06315	COG1408	metallophosphoesterase
CU648_RS06330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CU648_RS06370	COG2814	Major facilitator Superfamily
CU648_RS06395	COG3209	COG3209 Rhs family protein
CU648_RS06410	COG2205	protein histidine kinase activity
CU648_RS06420	COG0436	Aminotransferase
CU648_RS06425	COG1609	Transcriptional regulator
CU648_RS06430	COG3833	ABC-type maltose transport systems, permease component
CU648_RS06435	COG1175	transmembrane transport
CU648_RS06440	COG2182	Extracellular solute-binding protein
CU648_RS06450	COG0366	Alpha amylase catalytic
CU648_RS06455	COG3842	ATPase activity
CU648_RS06495	COG0183	Belongs to the thiolase family
CU648_RS06535	COG1695	Transcriptional regulator
CU648_RS06540	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS06560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU648_RS06565	COG0436	Aminotransferase
CU648_RS06600	COG2084	Dehydrogenase
CU648_RS06610	COG2199	diguanylate cyclase activity
CU648_RS06615	COG0778	Nitroreductase
CU648_RS06640	COG1263	PTS System
CU648_RS06640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_RS06640	COG2190	(PTS) system
CU648_RS06645	COG3711	transcriptional antiterminator
CU648_RS06655	COG2188	Transcriptional regulator
CU648_RS06665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CU648_RS06695	COG1547	Domain of unknown function (DUF309)
CU648_RS06700	COG0456	acetyltransferase
CU648_RS06710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CU648_RS06715	COG4086	secreted protein
CU648_RS06720	COG0561	phosphatase activity
CU648_RS06725	COG0697	spore germination
CU648_RS06740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_RS06765	COG0733	neurotransmitter:sodium symporter activity
CU648_RS06785	COG1686	Belongs to the peptidase S11 family
CU648_RS06795	COG1725	Transcriptional regulator
CU648_RS06800	COG1131	(ABC) transporter
CU648_RS06820	COG1846	Transcriptional regulator
CU648_RS06835	COG0598	Magnesium transport protein CorA
CU648_RS06860	COG4974	Belongs to the 'phage' integrase family
CU648_RS06870	COG0735	belongs to the Fur family
CU648_RS06875	COG1300	Membrane
CU648_RS06895	COG0667	Aldo Keto reductase
CU648_RS06900	COG0656	L-ascorbic acid biosynthetic process
CU648_RS06905	COG0456	acetyltransferase
CU648_RS06905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU648_RS06915	COG1525	nuclease
CU648_RS06915	COG4085	toxin activity
CU648_RS06915	COG0737	Belongs to the 5'-nucleotidase family
CU648_RS06925	COG0596	Alpha beta hydrolase
CU648_RS06930	COG2056	Na+-H+ antiporter family
CU648_RS06935	COG1609	Transcriptional regulator
CU648_RS06940	COG0456	acetyltransferase
CU648_RS06945	COG1073	alpha beta
CU648_RS06960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU648_RS06960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU648_RS06965	COG0307	riboflavin synthase, alpha
CU648_RS06990	COG4106	trans-aconitate 2-methyltransferase activity
CU648_RS06995	COG2267	carboxylic ester hydrolase activity
CU648_RS07010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU648_RS07025	COG1757	Na H antiporter
CU648_RS07030	COG0737	Belongs to the 5'-nucleotidase family
CU648_RS07040	COG1522	sequence-specific DNA binding
CU648_RS07060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU648_RS07070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CU648_RS07085	COG0300	oxidoreductase activity
CU648_RS07090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS07095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU648_RS07100	COG1760	l-serine dehydratase
CU648_RS07105	COG1760	l-serine dehydratase
CU648_RS07130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CU648_RS07140	COG2195	Cleaves the N-terminal amino acid of tripeptides
CU648_RS07145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_RS07160	COG1376	ErfK ybiS ycfS ynhG family protein
CU648_RS07165	COG4129	membrane
CU648_RS07170	COG1126	abc transporter atp-binding protein
CU648_RS07175	COG0765	amino acid transport
CU648_RS07180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_RS07200	COG2816	NAD+ diphosphatase activity
CU648_RS07205	COG0772	Belongs to the SEDS family
CU648_RS07215	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU648_RS07220	COG0022	dehydrogenase e1 component
CU648_RS07225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU648_RS07230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU648_RS07245	COG0280	phosphate acetyltransferase
CU648_RS07255	COG3829	transcription factor binding
CU648_RS07255	COG3290	protein histidine kinase activity
CU648_RS07265	COG0584	glycerophosphoryl diester phosphodiesterase
CU648_RS07270	COG3093	addiction module antidote protein HigA
CU648_RS07280	COG0745	RESPONSE REGULATOR receiver
CU648_RS07290	COG0750	zinc metalloprotease
CU648_RS07295	COG0497	DNA recombination
CU648_RS07305	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CU648_RS07315	COG0142	geranyltranstransferase activity
CU648_RS07340	COG1302	Protein conserved in bacteria
CU648_RS07345	COG0439	Biotin carboxylase
CU648_RS07350	COG0511	ligase activity, forming carbon-carbon bonds
CU648_RS07395	COG3854	ATPases associated with a variety of cellular activities
CU648_RS07420	COG0006	proline dipeptidase activity
CU648_RS07435	COG3872	metal-dependent enzyme
CU648_RS07445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU648_RS07465	COG0095	Lipoate-protein ligase
CU648_RS07470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_RS07475	COG1609	Transcriptional regulator
CU648_RS07485	COG2076	Multidrug Resistance protein
CU648_RS07490	COG2076	Multidrug Resistance protein
CU648_RS07530	COG1131	(ABC) transporter
CU648_RS07535	COG1725	Transcriptional regulator
CU648_RS07570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU648_RS07615	COG2169	Transcriptional regulator
CU648_RS07620	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CU648_RS07650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CU648_RS07655	COG2169	Transcriptional regulator
CU648_RS07680	COG2264	protein methyltransferase activity
CU648_RS07720	COG4970	Tfp pilus assembly protein FimT
CU648_RS07730	COG1459	type II secretion system
CU648_RS07735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CU648_RS07785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU648_RS07790	COG1410	methionine synthase
CU648_RS07790	COG0646	methionine synthase
CU648_RS07795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CU648_RS07795	COG0646	methionine synthase
CU648_RS07800	COG0626	cystathionine gamma-synthase activity
CU648_RS07805	COG0626	cystathionine gamma-synthase activity
CU648_RS07825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS07835	COG1940	carbohydrate kinase activity
CU648_RS07840	COG4483	Protein conserved in bacteria
CU648_RS07845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CU648_RS07850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CU648_RS07855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CU648_RS07860	COG0704	Plays a role in the regulation of phosphate uptake
CU648_RS07870	COG0581	inorganic phosphate transmembrane transporter activity
CU648_RS07875	COG0573	inorganic phosphate transmembrane transporter activity
CU648_RS07880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CU648_RS07885	COG0768	penicillin binding
CU648_RS07890	COG0477	Major facilitator Superfamily
CU648_RS07895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CU648_RS07920	COG0735	belongs to the Fur family
CU648_RS07925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU648_RS07930	COG1121	(ABC) transporter
CU648_RS07935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS07965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CU648_RS07970	COG2384	SAM-dependent methyltransferase
CU648_RS07975	COG2010	Cytochrome c
CU648_RS07980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CU648_RS07985	COG0358	DNA primase activity
CU648_RS08005	COG0517	IMP dehydrogenase activity
CU648_RS08020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CU648_RS08025	COG0295	cytidine deaminase activity
CU648_RS08030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CU648_RS08040	COG1480	7TM receptor with intracellular HD hydrolase
CU648_RS08045	COG1702	phosphate starvation-inducible protein PhoH
CU648_RS08065	COG1610	YqeY-like protein
CU648_RS08070	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CU648_RS08075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CU648_RS08080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CU648_RS08110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CU648_RS08115	COG1733	regulation of RNA biosynthetic process
CU648_RS08140	COG1466	dna polymerase III delta subunit
CU648_RS08150	COG0658	competence protein
CU648_RS08150	COG2333	competence protein COMEC
CU648_RS08155	COG2131	deaminase
CU648_RS08160	COG1596	polysaccharide export
CU648_RS08160	COG1555	photosystem II stabilization
CU648_RS08165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU648_RS08170	COG2226	methyltransferase
CU648_RS08175	COG0799	negative regulation of ribosome biogenesis
CU648_RS08180	COG1713	HD superfamily hydrolase involved in NAD metabolism
CU648_RS08190	COG1534	Rna-binding protein
CU648_RS08200	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CU648_RS08205	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CU648_RS08230	COG1595	DNA-templated transcription, initiation
CU648_RS08240	COG0778	Nitroreductase
CU648_RS08245	COG2357	RelA SpoT domain protein
CU648_RS08255	COG1785	Belongs to the alkaline phosphatase family
CU648_RS08265	COG2267	carboxylic ester hydrolase activity
CU648_RS08300	COG1404	Belongs to the peptidase S8 family
CU648_RS08305	COG3186	Phenylalanine-4-hydroxylase
CU648_RS08315	COG2514	catechol 2,3-dioxygenase activity
CU648_RS08320	COG2259	Doxx family
CU648_RS08360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_RS08370	COG1454	alcohol dehydrogenase
CU648_RS08370	COG1012	belongs to the aldehyde dehydrogenase family
CU648_RS08375	COG0626	cystathionine gamma-synthase activity
CU648_RS08380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU648_RS08405	COG0768	penicillin binding
CU648_RS08420	COG0826	peptidase U32
CU648_RS08425	COG0826	peptidase U32
CU648_RS08430	COG4122	O-methyltransferase activity
CU648_RS08435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CU648_RS08465	COG0628	permease
CU648_RS08485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CU648_RS08500	COG1104	cysteine desulfurase activity
CU648_RS08505	COG1959	2 iron, 2 sulfur cluster binding
CU648_RS08510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CU648_RS08525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CU648_RS08555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CU648_RS08565	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CU648_RS08565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CU648_RS08570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CU648_RS08575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU648_RS08575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU648_RS08585	COG2244	polysaccharide biosynthetic process
CU648_RS08590	COG2323	membrane
CU648_RS08600	COG1862	Preprotein translocase
CU648_RS08630	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CU648_RS08665	COG0157	Belongs to the NadC ModD family
CU648_RS08670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CU648_RS08675	COG1104	cysteine desulfurase activity
CU648_RS08680	COG1827	regulation of RNA biosynthetic process
CU648_RS08685	COG2258	MOSC domain
CU648_RS08690	COG0077	Prephenate dehydratase
CU648_RS08695	COG0577	efflux transmembrane transporter activity
CU648_RS08700	COG0577	efflux transmembrane transporter activity
CU648_RS08705	COG1136	(ABC) transporter
CU648_RS08710	COG5002	protein histidine kinase activity
CU648_RS08715	COG0745	RESPONSE REGULATOR receiver
CU648_RS08725	COG3290	protein histidine kinase activity
CU648_RS08735	COG2868	ribosomal protein
CU648_RS08745	COG1530	ribonuclease E activity
CU648_RS08750	COG1994	Peptidase M50
CU648_RS08755	COG0739	heme binding
CU648_RS08760	COG2894	cell division
CU648_RS08780	COG1077	Cell shape determining protein MreB Mrl
CU648_RS08790	COG0477	Major facilitator Superfamily
CU648_RS08795	COG2249	NAD(P)H dehydrogenase (quinone) activity
CU648_RS08835	COG0285	dihydrofolate synthase activity
CU648_RS08840	COG0525	valine-tRNA ligase activity
CU648_RS08850	COG1388	LysM domain
CU648_RS08860	COG0113	porphobilinogen synthase activity
CU648_RS08865	COG1587	Uroporphyrinogen-III synthase
CU648_RS08875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU648_RS08885	COG1846	Transcriptional regulator
CU648_RS08890	COG1764	response to oxidative stress
CU648_RS08905	COG0470	DNA polymerase III
CU648_RS08905	COG1067	ATP-dependent peptidase activity
CU648_RS08960	COG0622	Phosphoesterase
CU648_RS08975	COG5401	PFAM Sporulation and spore germination
CU648_RS08995	COG1309	transcriptional regulator
CU648_RS09010	COG2197	response regulator
CU648_RS09015	COG2233	PERMEase
CU648_RS09025	COG0402	S-adenosylhomocysteine deaminase activity
CU648_RS09030	COG0402	S-adenosylhomocysteine deaminase activity
CU648_RS09040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU648_RS09050	COG0444	Belongs to the ABC transporter superfamily
CU648_RS09055	COG4608	Belongs to the ABC transporter superfamily
CU648_RS09060	COG3275	phosphorelay sensor kinase activity
CU648_RS09065	COG3279	Response regulator of the LytR AlgR family
CU648_RS09075	COG1983	PspC domain protein
CU648_RS09080	COG1396	sequence-specific DNA binding
CU648_RS09085	COG0697	spore germination
CU648_RS09095	COG1959	2 iron, 2 sulfur cluster binding
CU648_RS09100	COG1668	transmembrane transport
CU648_RS09105	COG4152	abc transporter atp-binding protein
CU648_RS09110	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CU648_RS09115	COG1360	Flagellar Motor Protein
CU648_RS09120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CU648_RS09125	COG1876	peptidase activity
CU648_RS09130	COG0824	Thioesterase
CU648_RS09135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CU648_RS09140	COG1053	succinate dehydrogenase
CU648_RS09145	COG2009	succinate dehydrogenase
CU648_RS09150	COG1719	4-vinyl reductase, 4VR
CU648_RS09160	COG3118	belongs to the thioredoxin family
CU648_RS09165	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CU648_RS09170	COG2086	electron transfer activity
CU648_RS09175	COG1024	Enoyl-CoA hydratase
CU648_RS09180	COG1309	transcriptional regulator
CU648_RS09185	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_RS09210	COG2318	DinB family
CU648_RS09235	COG1131	(ABC) transporter
CU648_RS09240	COG2205	protein histidine kinase activity
CU648_RS09245	COG0745	RESPONSE REGULATOR receiver
CU648_RS09255	COG4895	conserved protein (DUF2196)
CU648_RS09260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CU648_RS09275	COG4509	Sortase family
CU648_RS09280	COG1120	ATPase activity
CU648_RS09295	COG5386	Cell surface protein
CU648_RS09300	COG5386	Cell surface protein
CU648_RS09305	COG1114	Component of the transport system for branched-chain amino acids
CU648_RS09310	COG1187	pseudouridine synthase activity
CU648_RS09325	COG1796	DNA polymerase
CU648_RS09325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CU648_RS09330	COG1286	toxin biosynthetic process
CU648_RS09375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU648_RS09385	COG1418	mRNA catabolic process
CU648_RS09415	COG2814	Major facilitator Superfamily
CU648_RS09420	COG1566	PFAM secretion protein HlyD family protein
CU648_RS09425	COG1309	transcriptional regulator
CU648_RS09430	COG1363	Peptidase, m42
CU648_RS09455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CU648_RS09465	COG1484	DNA-dependent DNA replication
CU648_RS09470	COG3611	Membrane attachment protein
CU648_RS09480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CU648_RS09490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CU648_RS09495	COG0237	dephospho-CoA kinase activity
CU648_RS09500	COG1971	Probably functions as a manganese efflux pump
CU648_RS09510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU648_RS09510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU648_RS09515	COG5002	protein histidine kinase activity
CU648_RS09520	COG0745	RESPONSE REGULATOR receiver
CU648_RS09545	COG0538	isocitrate dehydrogenase activity
CU648_RS09550	COG0372	Belongs to the citrate synthase family
CU648_RS09565	COG0628	permease
CU648_RS09570	COG3030	protein affecting phage T7 exclusion by the F plasmid
CU648_RS09595	COG1725	Transcriptional regulator
CU648_RS09600	COG0281	malic enzyme
CU648_RS09605	COG0587	DNA-directed DNA polymerase activity
CU648_RS09620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CU648_RS09640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CU648_RS09650	COG4109	DRTGG domain
CU648_RS09665	COG0006	proline dipeptidase activity
CU648_RS09705	COG0662	Cupin 2, conserved barrel domain protein
CU648_RS09715	COG1476	TRANSCRIPTIONal
CU648_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS09735	COG0589	response to stress
CU648_RS09785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS09805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CU648_RS09810	COG0827	DNA restriction-modification system
CU648_RS09815	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CU648_RS09820	COG3874	Sporulation protein YtfJ
CU648_RS09835	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CU648_RS09845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU648_RS09860	COG1104	cysteine desulfurase activity
CU648_RS09870	COG0583	DNA-binding transcription factor activity
CU648_RS09875	COG0697	spore germination
CU648_RS09880	COG1309	transcriptional regulator
CU648_RS09885	COG1956	GAF domain-containing protein
CU648_RS09890	COG0626	cystathionine gamma-synthase activity
CU648_RS09950	COG1595	DNA-templated transcription, initiation
CU648_RS09965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU648_RS09970	COG0454	-acetyltransferase
CU648_RS09975	COG0517	IMP dehydrogenase activity
CU648_RS09980	COG0123	including yeast histone deacetylase and acetoin utilization protein
CU648_RS09990	COG0745	RESPONSE REGULATOR receiver
CU648_RS09995	COG5002	protein histidine kinase activity
CU648_RS10005	COG0666	response to abiotic stimulus
CU648_RS10040	COG1609	Transcriptional regulator
CU648_RS10055	COG4851	CamS sex pheromone cAM373 precursor
CU648_RS10060	COG3118	belongs to the thioredoxin family
CU648_RS10070	COG2309	aminopeptidase activity
CU648_RS10090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_RS10095	COG1695	Transcriptional regulator
CU648_RS10115	COG1674	ftsk spoiiie
CU648_RS10125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU648_RS10135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_RS10140	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CU648_RS10145	COG1363	Peptidase, m42
CU648_RS10155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS10170	COG0510	thiamine kinase activity
CU648_RS10175	COG1523	belongs to the glycosyl hydrolase 13 family
CU648_RS10190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU648_RS10195	COG1349	DNA-binding transcription factor activity
CU648_RS10200	COG1187	pseudouridine synthase activity
CU648_RS10205	COG2244	polysaccharide biosynthetic process
CU648_RS10210	COG2081	HI0933 family
CU648_RS10215	COG2814	Major facilitator Superfamily
CU648_RS10225	COG3832	glyoxalase III activity
CU648_RS10250	COG1329	Transcriptional regulator
CU648_RS10275	COG0314	molybdopterin synthase activity
CU648_RS10290	COG1763	Mo-molybdopterin cofactor biosynthetic process
CU648_RS10295	COG0303	'Molybdopterin
CU648_RS10305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU648_RS10310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CU648_RS10330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_RS10340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU648_RS10385	COG2814	Major facilitator Superfamily
CU648_RS10390	COG0475	glutathione-regulated potassium exporter activity
CU648_RS10395	COG0490	domain, Protein
CU648_RS10400	COG0582	viral genome integration into host DNA
CU648_RS10410	COG1136	(ABC) transporter
CU648_RS10435	COG1242	4 iron, 4 sulfur cluster binding
CU648_RS10440	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CU648_RS10455	COG1794	racemase activity, acting on amino acids and derivatives
CU648_RS10480	COG2267	carboxylic ester hydrolase activity
CU648_RS10485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CU648_RS10490	COG0671	phosphoesterase, PA-phosphatase related
CU648_RS10495	COG0438	transferase activity, transferring glycosyl groups
CU648_RS10505	COG0521	Mo-molybdopterin cofactor biosynthetic process
CU648_RS10570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CU648_RS10575	COG5002	protein histidine kinase activity
CU648_RS10580	COG4191	Histidine kinase
CU648_RS10585	COG2267	carboxylic ester hydrolase activity
CU648_RS10590	COG1368	sulfuric ester hydrolase activity
CU648_RS10610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU648_RS10615	COG1116	anion transmembrane transporter activity
CU648_RS10620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU648_RS10635	COG0546	phosphoglycolate phosphatase activity
CU648_RS10645	COG0494	nUDIX hydrolase
CU648_RS10685	COG0288	reversible hydration of carbon dioxide
CU648_RS10690	COG1271	oxidase subunit
CU648_RS10695	COG1294	oxidase, subunit
CU648_RS10745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS10770	COG1842	Phage shock protein A
CU648_RS10825	COG5002	protein histidine kinase activity
CU648_RS10830	COG0745	RESPONSE REGULATOR receiver
CU648_RS10855	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CU648_RS10860	COG1597	lipid kinase activity
CU648_RS10875	COG0577	efflux transmembrane transporter activity
CU648_RS10880	COG1136	(ABC) transporter
CU648_RS10895	COG0586	Pfam SNARE associated Golgi protein
CU648_RS10905	COG4977	sequence-specific DNA binding
CU648_RS10915	COG0577	efflux transmembrane transporter activity
CU648_RS10920	COG1136	(ABC) transporter
CU648_RS10925	COG3708	Transcriptional regulator
CU648_RS10925	COG2207	Transcriptional regulator
CU648_RS10930	COG0745	RESPONSE REGULATOR receiver
CU648_RS10935	COG2205	protein histidine kinase activity
CU648_RS10940	COG0577	efflux transmembrane transporter activity
CU648_RS10945	COG0577	efflux transmembrane transporter activity
CU648_RS10950	COG1136	(ABC) transporter
CU648_RS10955	COG0577	efflux transmembrane transporter activity
CU648_RS10970	COG2188	Transcriptional regulator
CU648_RS10990	COG3964	amidohydrolase
CU648_RS11010	COG4948	Mandelate Racemase Muconate Lactonizing
CU648_RS11025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU648_RS11030	COG0596	Alpha beta hydrolase
CU648_RS11040	COG1169	isochorismate synthase
CU648_RS11045	COG1575	Belongs to the MenA family. Type 1 subfamily
CU648_RS11050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CU648_RS11075	COG0058	SHG alpha-glucan phosphorylase activity
CU648_RS11085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CU648_RS11105	COG1404	Belongs to the peptidase S8 family
CU648_RS11210	COG0544	peptidyl-prolyl cis-trans isomerase activity
CU648_RS11250	COG1285	pathogenesis
CU648_RS11255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CU648_RS11275	COG2155	Conserved Protein
CU648_RS11280	COG1098	S1 RNA binding domain
CU648_RS11285	COG0436	Aminotransferase
CU648_RS11290	COG1522	sequence-specific DNA binding
CU648_RS11295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CU648_RS11300	COG2267	carboxylic ester hydrolase activity
CU648_RS11310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CU648_RS11325	COG5018	Exonuclease
CU648_RS11330	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CU648_RS11355	COG2050	protein possibly involved in aromatic compounds catabolism
CU648_RS11365	COG1268	BioY protein
CU648_RS11370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CU648_RS11375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU648_RS11390	COG3584	3D domain protein
CU648_RS11405	COG1252	NADH dehydrogenase
CU648_RS11420	COG3708	Transcriptional regulator
CU648_RS11435	COG1683	Conserved Protein
CU648_RS11455	COG0316	Belongs to the HesB IscA family
CU648_RS11470	COG1252	NADH dehydrogenase
CU648_RS11480	COG2274	protein secretion by the type I secretion system
CU648_RS11485	COG0390	transport system, permease component
CU648_RS11490	COG2824	Alkylphosphonate utilization operon protein PhnA
CU648_RS11530	COG4837	Protein of unknown function (DUF1462)
CU648_RS11535	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CU648_RS11550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CU648_RS11555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CU648_RS11565	COG2249	NAD(P)H dehydrogenase (quinone) activity
CU648_RS11575	COG0647	UMP catabolic process
CU648_RS11585	COG2445	Protein of unknown function DUF86
CU648_RS11590	COG1494	fructose-1,6-bisphosphatase
CU648_RS11610	COG4470	Protein conserved in bacteria
CU648_RS11620	COG0789	Transcriptional regulator
CU648_RS11625	COG4377	Putative membrane peptidase family (DUF2324)
CU648_RS11650	COG0739	heme binding
CU648_RS11660	COG3377	Domain of unknown function (DUF1805)
CU648_RS11665	COG0737	Belongs to the 5'-nucleotidase family
CU648_RS11680	COG0719	Fe-S assembly protein
CU648_RS11685	COG0822	iron-sulfur transferase activity
CU648_RS11690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU648_RS11695	COG0719	Fe-S assembly protein
CU648_RS11700	COG0396	ATPase activity
CU648_RS11705	COG1464	Belongs to the NlpA lipoprotein family
CU648_RS11710	COG1464	Belongs to the NlpA lipoprotein family
CU648_RS11715	COG2011	ABC-type metal ion transport system permease component
CU648_RS11720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CU648_RS11730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_RS11735	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CU648_RS11745	COG1393	Belongs to the ArsC family
CU648_RS11800	COG0039	L-malate dehydrogenase activity
CU648_RS11825	COG1396	sequence-specific DNA binding
CU648_RS11830	COG1309	transcriptional regulator
CU648_RS11835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS11840	COG1960	acyl-CoA dehydrogenase activity
CU648_RS11850	COG0183	Belongs to the thiolase family
CU648_RS11855	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU648_RS11855	COG1024	Enoyl-CoA hydratase
CU648_RS11870	COG1686	Belongs to the peptidase S11 family
CU648_RS11885	COG0011	TIGRFAM Protein of
CU648_RS11890	COG0840	transmembrane signaling receptor activity
CU648_RS11905	COG2814	Major facilitator Superfamily
CU648_RS11910	COG0531	amino acid
CU648_RS11925	COG0706	membrane insertase activity
CU648_RS11935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS11980	COG0586	Pfam SNARE associated Golgi protein
CU648_RS11990	COG1376	ErfK ybiS ycfS ynhG family protein
CU648_RS11995	COG0745	RESPONSE REGULATOR receiver
CU648_RS12000	COG5002	protein histidine kinase activity
CU648_RS12030	COG0840	transmembrane signaling receptor activity
CU648_RS12035	COG2151	metal-sulfur cluster biosynthetic enzyme
CU648_RS12040	COG3227	Zinc metalloprotease (Elastase)
CU648_RS12045	COG1741	Belongs to the pirin family
CU648_RS12060	COG0475	glutathione-regulated potassium exporter activity
CU648_RS12065	COG0490	domain, Protein
CU648_RS12075	COG1115	amino acid carrier protein
CU648_RS12080	COG0783	Belongs to the Dps family
CU648_RS12100	COG1611	Belongs to the LOG family
CU648_RS12120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_RS12125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_RS12130	COG1115	amino acid carrier protein
CU648_RS12135	COG1115	amino acid carrier protein
CU648_RS12140	COG2910	NAD(P)H-binding
CU648_RS12165	COG0656	L-ascorbic acid biosynthetic process
CU648_RS12170	COG2814	Major facilitator Superfamily
CU648_RS12175	COG1733	regulation of RNA biosynthetic process
CU648_RS12185	COG1252	NADH dehydrogenase
CU648_RS12190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CU648_RS12205	COG3290	protein histidine kinase activity
CU648_RS12205	COG0840	transmembrane signaling receptor activity
CU648_RS12235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_RS12245	COG2814	Major facilitator Superfamily
CU648_RS12365	COG0557	exoribonuclease II activity
CU648_RS12370	COG1647	Serine aminopeptidase, S33
CU648_RS12375	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CU648_RS12380	COG1346	cytolysis
CU648_RS12415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CU648_RS12430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CU648_RS12455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_RS12470	COG2323	membrane
CU648_RS12485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU648_RS12495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CU648_RS12505	COG1051	belongs to the nudix hydrolase family
CU648_RS12515	COG0492	ferredoxin-NADP+ reductase activity
CU648_RS12520	COG0457	Tetratricopeptide repeat
CU648_RS12525	COG0110	maltose O-acetyltransferase activity
CU648_RS12545	COG1950	PFAM Membrane protein of
CU648_RS12555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU648_RS12575	COG0789	Transcriptional regulator
CU648_RS12615	COG0583	DNA-binding transcription factor activity
CU648_RS12625	COG0655	NAD(P)H dehydrogenase (quinone) activity
CU648_RS12640	COG1132	(ABC) transporter
CU648_RS12650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU648_RS12655	COG3409	Peptidoglycan-binding domain 1 protein
CU648_RS12655	COG0793	Belongs to the peptidase S41A family
CU648_RS12660	COG2177	Part of the ABC transporter FtsEX involved in
CU648_RS12665	COG2884	Cell division ATP-binding protein ftsE
CU648_RS12690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CU648_RS12695	COG1278	Cold shock
CU648_RS12700	COG1040	competence protein
CU648_RS12705	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CU648_RS12710	COG1388	LysM domain
CU648_RS12710	COG0791	NLP P60 protein
CU648_RS12715	COG1733	regulation of RNA biosynthetic process
CU648_RS12725	COG1307	EDD domain protein, DegV family
CU648_RS12730	COG1739	Uncharacterized protein family UPF0029
CU648_RS12735	COG1316	TRANSCRIPTIONal
CU648_RS12740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CU648_RS12745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU648_RS12750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CU648_RS12760	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CU648_RS12760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CU648_RS12790	COG3394	polysaccharide catabolic process
CU648_RS12795	COG1486	melibiose metabolic process
CU648_RS12800	COG1447	Phosphotransferase system cellobiose-specific component IIA
CU648_RS12805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CU648_RS12815	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CU648_RS12825	COG1447	Phosphotransferase system cellobiose-specific component IIA
CU648_RS12835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CU648_RS12840	COG1301	dicarboxylic acid transport
CU648_RS12875	COG1511	domain protein
CU648_RS12880	COG0583	DNA-binding transcription factor activity
CU648_RS12885	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CU648_RS12900	COG1271	oxidase subunit
CU648_RS12905	COG1294	oxidase, subunit
CU648_RS12910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CU648_RS12945	COG1620	l-lactate permease
CU648_RS12955	COG2389	metal-binding protein
CU648_RS12970	COG1368	sulfuric ester hydrolase activity
CU648_RS12985	COG1388	LysM domain
CU648_RS12985	COG0791	NLP P60 protein
CU648_RS12990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_RS13000	COG1215	transferase activity, transferring glycosyl groups
CU648_RS13010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU648_RS13020	COG3584	3D domain protein
CU648_RS13020	COG1388	LysM domain
CU648_RS13045	COG4715	Zinc finger, swim domain protein
CU648_RS13050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU648_RS13095	COG0577	efflux transmembrane transporter activity
CU648_RS13100	COG1136	(ABC) transporter
CU648_RS13125	COG5002	protein histidine kinase activity
CU648_RS13130	COG0745	RESPONSE REGULATOR receiver
CU648_RS13135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU648_RS13145	COG1316	TRANSCRIPTIONal
CU648_RS13155	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU648_RS13165	COG1215	transferase activity, transferring glycosyl groups
CU648_RS13185	COG0438	transferase activity, transferring glycosyl groups
CU648_RS13190	COG1045	serine acetyltransferase
CU648_RS13195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CU648_RS13200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CU648_RS13205	COG1086	Polysaccharide biosynthesis protein
CU648_RS13210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CU648_RS13215	COG4464	protein tyrosine phosphatase activity
CU648_RS13220	COG0489	protein tyrosine kinase activity
CU648_RS13225	COG3944	biosynthesis protein
CU648_RS13230	COG0489	protein tyrosine kinase activity
CU648_RS13245	COG1609	Transcriptional regulator
CU648_RS13255	COG0739	heme binding
CU648_RS13270	COG3279	Response regulator of the LytR AlgR family
CU648_RS13275	COG2385	sporulation resulting in formation of a cellular spore
CU648_RS13290	COG4836	Membrane
CU648_RS13295	COG1007	ATP synthesis coupled electron transport
CU648_RS13300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU648_RS13305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CU648_RS13315	COG0839	Belongs to the complex I subunit 6 family
CU648_RS13330	COG0649	NAD binding
CU648_RS13335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU648_RS13350	COG5001	Diguanylate cyclase
CU648_RS13350	COG3300	MHYT domain
CU648_RS13405	COG0356	it plays a direct role in the translocation of protons across the membrane
CU648_RS13440	COG0698	ribose 5-phosphate isomerase
CU648_RS13455	COG2190	(PTS) system
CU648_RS13460	COG2259	Doxx family
CU648_RS13465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU648_RS13485	COG0009	L-threonylcarbamoyladenylate synthase
CU648_RS13500	COG2890	protein-(glutamine-N5) methyltransferase activity
CU648_RS13520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CU648_RS13525	COG1494	fructose-1,6-bisphosphatase
CU648_RS13550	COG4821	SIS domain
CU648_RS13570	COG1960	acyl-CoA dehydrogenase activity
CU648_RS13575	COG1960	acyl-CoA dehydrogenase activity
CU648_RS13580	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU648_RS13585	COG0183	Belongs to the thiolase family
CU648_RS13590	COG0247	lactate metabolic process
CU648_RS13590	COG2181	nitrate reductase activity
CU648_RS13595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_RS13605	COG5001	Diguanylate cyclase
CU648_RS13605	COG3300	MHYT domain
CU648_RS13625	COG2197	response regulator
CU648_RS13630	COG4585	Histidine kinase
CU648_RS13635	COG0842	Transport permease protein
CU648_RS13640	COG1131	(ABC) transporter
CU648_RS13645	COG0024	Methionine aminopeptidase
CU648_RS13660	COG2234	aminopeptidase activity
CU648_RS13680	COG1595	DNA-templated transcription, initiation
CU648_RS13690	COG4506	Protein conserved in bacteria
CU648_RS13695	COG1619	proteins homologs of microcin C7 resistance protein MccF
CU648_RS13710	COG0010	Belongs to the arginase family
CU648_RS13720	COG2814	Major facilitator Superfamily
CU648_RS13725	COG0789	Transcriptional regulator
CU648_RS13730	COG0584	glycerophosphoryl diester phosphodiesterase
CU648_RS13735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_RS13745	COG1994	Peptidase M50
CU648_RS13755	COG1078	dGTPase activity
CU648_RS13760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_RS13765	COG1120	ATPase activity
CU648_RS13770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS13775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS13795	COG0095	Lipoate-protein ligase
CU648_RS13800	COG0280	phosphate acetyltransferase
CU648_RS13815	COG3773	Cell wall hydrolase
CU648_RS13825	COG2363	Small membrane protein
CU648_RS13835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CU648_RS13840	COG2233	PERMEase
CU648_RS13845	COG0561	phosphatase activity
CU648_RS13850	COG2814	Major facilitator Superfamily
CU648_RS13875	COG1476	TRANSCRIPTIONal
CU648_RS13880	COG3118	belongs to the thioredoxin family
CU648_RS13890	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CU648_RS13895	COG1131	(ABC) transporter
CU648_RS13900	COG2755	lipolytic protein G-D-S-L family
CU648_RS13905	COG1609	Transcriptional regulator
CU648_RS13915	COG0460	homoserine dehydrogenase
CU648_RS13925	COG2873	o-acetylhomoserine
CU648_RS13935	COG1011	Hydrolase
CU648_RS13940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU648_RS13950	COG2197	response regulator
CU648_RS13955	COG4585	Histidine kinase
CU648_RS13955	COG2203	Gaf domain
CU648_RS13960	COG0351	phosphomethylpyrimidine kinase
CU648_RS13965	COG3706	GGDEF domain
CU648_RS13970	COG2879	small protein
CU648_RS13975	COG1966	Carbon starvation protein
CU648_RS13980	COG3279	Response regulator of the LytR AlgR family
CU648_RS13985	COG0477	Major facilitator Superfamily
CU648_RS14010	COG0840	transmembrane signaling receptor activity
CU648_RS14020	COG1607	acyl-coa hydrolase
CU648_RS14035	COG0488	(ABC) transporter
CU648_RS14055	COG0463	Glycosyl transferase, family 2
CU648_RS14060	COG1309	transcriptional regulator
CU648_RS14065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU648_RS14070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU648_RS14070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU648_RS14075	COG0628	permease
CU648_RS14090	COG3279	Response regulator of the LytR AlgR family
CU648_RS14095	COG3275	phosphorelay sensor kinase activity
CU648_RS14100	COG2814	Major facilitator Superfamily
CU648_RS14105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU648_RS14110	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CU648_RS14120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CU648_RS14140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU648_RS14145	COG1272	protein, Hemolysin III
CU648_RS14170	COG1164	Oligoendopeptidase f
CU648_RS14190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU648_RS14195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CU648_RS14200	COG4853	Protein conserved in bacteria
CU648_RS14205	COG4863	YycH protein
CU648_RS14210	COG5002	protein histidine kinase activity
CU648_RS14215	COG0745	RESPONSE REGULATOR receiver
CU648_RS14245	COG0305	Participates in initiation and elongation during chromosome replication
CU648_RS14255	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CU648_RS14260	COG4241	membrane
CU648_RS14270	COG0629	single-stranded DNA binding
CU648_RS14280	COG0012	GTP binding
CU648_RS14285	COG4481	Protein conserved in bacteria
CU648_RS14290	COG0668	transmembrane transport
CU648_RS14300	COG1475	DNA binding
CU648_RS14305	COG1192	Involved in chromosome partitioning
CU648_RS14330	COG1847	R3H domain protein
CU648_RS14335	COG0706	membrane insertase activity
CU648_RS14345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CU648_RS14355	COG0592	DNA-directed DNA polymerase activity
CU648_RS14360	COG2501	S4 domain
CU648_RS14370	COG0187	DNA topoisomerase II activity
CU648_RS14375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU648_RS14410	COG0516	GMP reductase activity
CU648_RS14410	COG0517	IMP dehydrogenase activity
CU648_RS14415	COG1686	Belongs to the peptidase S11 family
CU648_RS14445	COG1428	Deoxynucleoside kinase
CU648_RS14450	COG1428	Deoxynucleoside kinase
CU648_RS14455	COG1335	isochorismatase
CU648_RS14465	COG0590	tRNA wobble adenosine to inosine editing
CU648_RS14475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CU648_RS14530	COG1982	Orn Lys Arg decarboxylase major
CU648_RS14540	COG0470	DNA polymerase III
CU648_RS14545	COG1774	PSP1 C-terminal conserved region
CU648_RS14555	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CU648_RS14565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CU648_RS14570	COG2002	toxin-antitoxin pair type II binding
CU648_RS14575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU648_RS14575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU648_RS14580	COG0084	hydrolase, TatD family'
CU648_RS14585	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CU648_RS14600	COG4466	Protein conserved in bacteria
CU648_RS14615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CU648_RS14625	COG0251	oxidation-reduction process
CU648_RS14655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CU648_RS14660	COG2002	toxin-antitoxin pair type II binding
CU648_RS14665	COG2244	polysaccharide biosynthetic process
CU648_RS14670	COG3956	TIGRFAM MazG family protein
CU648_RS14675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CU648_RS14695	COG1098	S1 RNA binding domain
CU648_RS14710	COG2208	phosphoserine phosphatase activity
CU648_RS14720	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CU648_RS14725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU648_RS14740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU648_RS14745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CU648_RS14750	COG0512	Glutamine amidotransferase of anthranilate synthase
CU648_RS14755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU648_RS14760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CU648_RS14765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CU648_RS14770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CU648_RS14775	COG1396	sequence-specific DNA binding
CU648_RS14780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CU648_RS14870	COG3880	PFAM UvrB UvrC protein
CU648_RS14880	COG0542	response to heat
CU648_RS14885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CU648_RS14895	COG4956	integral membrane protein (PIN domain superfamily)
CU648_RS14915	COG1045	serine acetyltransferase
CU648_RS14930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU648_RS14935	COG3688	RNA-binding protein containing a PIN domain
CU648_RS14950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CU648_RS14955	COG0250	Participates in transcription elongation, termination and antitermination
CU648_RS14960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CU648_RS14980	COG2813	Specifically methylates the guanine in position
CU648_RS14995	COG1358	cellular component organization or biogenesis
CU648_RS15065	COG0255	Belongs to the universal ribosomal protein uL29 family
CU648_RS15125	COG0201	protein transport
CU648_RS15135	COG0024	Methionine aminopeptidase
CU648_RS15145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CU648_RS15180	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CU648_RS15205	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU648_RS15210	COG0489	protein tyrosine kinase activity
CU648_RS15220	COG2194	sulfuric ester hydrolase activity
CU648_RS15225	COG0726	polysaccharide deacetylase
CU648_RS15305	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CU648_RS15310	COG4856	YbbR-like protein
CU648_RS15360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CU648_RS15385	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS15390	COG2011	ABC-type metal ion transport system permease component
CU648_RS15400	COG1464	Belongs to the NlpA lipoprotein family
CU648_RS15405	COG0604	alcohol dehydrogenase
CU648_RS15415	COG0277	FAD linked oxidase domain protein
CU648_RS15420	COG2271	Major facilitator Superfamily
CU648_RS15430	COG2814	Major facilitator Superfamily
CU648_RS15445	COG0601	transmembrane transport
CU648_RS15450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU648_RS15455	COG0444	Belongs to the ABC transporter superfamily
CU648_RS15460	COG4608	Belongs to the ABC transporter superfamily
CU648_RS15465	COG4166	transmembrane transport
CU648_RS15475	COG2207	Transcriptional regulator
CU648_RS15485	COG1309	transcriptional regulator
CU648_RS15495	COG4166	transmembrane transport
CU648_RS15500	COG4166	transmembrane transport
CU648_RS15505	COG0656	L-ascorbic acid biosynthetic process
CU648_RS15510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU648_RS15535	COG4149	molybdate abc transporter
CU648_RS15540	COG0725	ABC transporter, periplasmic molybdate-binding protein
CU648_RS15545	COG1910	domain protein
CU648_RS15565	COG0697	spore germination
CU648_RS15580	COG0204	Acyl-transferase
CU648_RS15595	COG1609	Transcriptional regulator
CU648_RS15605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS15630	COG5298	Protein conserved in bacteria
CU648_RS15655	COG0488	(ABC) transporter
CU648_RS15665	COG0747	negative chemotaxis
CU648_RS15670	COG0747	negative chemotaxis
CU648_RS15675	COG0601	transmembrane transport
CU648_RS15680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU648_RS15685	COG0444	Belongs to the ABC transporter superfamily
CU648_RS15690	COG4608	Belongs to the ABC transporter superfamily
CU648_RS15695	COG0561	phosphatase activity
CU648_RS15730	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CU648_RS15735	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU648_RS15750	COG0531	amino acid
CU648_RS15755	COG2814	Major facilitator Superfamily
CU648_RS15765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CU648_RS15775	COG4294	response to UV
CU648_RS15780	COG0457	Tetratricopeptide repeat
CU648_RS15780	COG0705	Rhomboid family
CU648_RS15790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CU648_RS15795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CU648_RS15800	COG0864	Transcriptional regulator
CU648_RS15805	COG2337	Toxic component of a toxin-antitoxin (TA) module
CU648_RS15810	COG2183	response to ionizing radiation
CU648_RS15905	COG0802	atpase or kinase
CU648_RS15910	COG1214	PFAM Peptidase M22, glycoprotease
CU648_RS15915	COG0456	acetyltransferase
CU648_RS15925	COG0488	(ABC) transporter
CU648_RS15940	COG1266	CAAX protease self-immunity
CU648_RS15955	COG1192	Involved in chromosome partitioning
CU648_RS15975	COG2252	PERMEase
CU648_RS15985	COG5002	protein histidine kinase activity
CU648_RS16010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU648_RS16050	COG2205	protein histidine kinase activity
CU648_RS16055	COG0745	RESPONSE REGULATOR receiver
CU648_RS16075	COG0697	spore germination
CU648_RS16105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CU648_RS16110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CU648_RS16115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CU648_RS16125	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CU648_RS16140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CU648_RS16150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CU648_RS16160	COG0151	Belongs to the GarS family
CU648_RS16190	COG0210	DNA helicase
CU648_RS16200	COG4851	CamS sex pheromone cAM373 precursor
CU648_RS16220	COG1335	isochorismatase
CU648_RS16230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CU648_RS16235	COG2011	ABC-type metal ion transport system permease component
CU648_RS16240	COG1464	Belongs to the NlpA lipoprotein family
CU648_RS16255	COG0003	Pfam Anion-transporting ATPase
CU648_RS16260	COG1846	Transcriptional regulator
CU648_RS16265	COG4682	membrane
CU648_RS16285	COG1597	lipid kinase activity
CU648_RS16290	COG0546	phosphoglycolate phosphatase activity
CU648_RS16295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CU648_RS16305	COG1012	belongs to the aldehyde dehydrogenase family
CU648_RS16310	COG2076	Multidrug Resistance protein
CU648_RS16315	COG2309	aminopeptidase activity
CU648_RS16330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_RS16335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CU648_RS16340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CU648_RS16345	COG5002	protein histidine kinase activity
CU648_RS16350	COG4807	Protein conserved in bacteria
CU648_RS16375	COG1757	Na H antiporter
CU648_RS16380	COG1473	amidohydrolase
CU648_RS16395	COG0450	alkyl hydroperoxide reductase
CU648_RS16415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS16420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS16425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_RS16450	COG0166	Belongs to the GPI family
CU648_RS16490	COG5002	protein histidine kinase activity
CU648_RS16510	COG3541	Predicted nucleotidyltransferase
CU648_RS16515	COG2814	Major facilitator Superfamily
CU648_RS16520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU648_RS16520	COG0723	plastoquinol--plastocyanin reductase activity
CU648_RS16545	COG0765	amino acid transport
CU648_RS16550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_RS16565	COG0840	transmembrane signaling receptor activity
CU648_RS16570	COG0840	transmembrane signaling receptor activity
CU648_RS16575	COG0366	Alpha amylase catalytic
CU648_RS16580	COG2190	(PTS) system
CU648_RS16580	COG1263	PTS System
CU648_RS16580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_RS16610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CU648_RS16625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU648_RS16635	COG1116	anion transmembrane transporter activity
CU648_RS16645	COG0488	(ABC) transporter
CU648_RS16695	COG2270	Major facilitator Superfamily
CU648_RS16725	COG2310	stress, protein
CU648_RS16730	COG2310	stress, protein
CU648_RS16735	COG2310	stress, protein
CU648_RS16740	COG0861	Integral membrane protein TerC family
CU648_RS16750	COG3853	Toxic anion resistance protein (TelA)
CU648_RS16765	COG0456	acetyltransferase
CU648_RS16775	COG0456	acetyltransferase
CU648_RS16800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CU648_RS16810	COG1295	ribonuclease BN
CU648_RS16820	COG2217	Heavy metal translocating P-type atpase
CU648_RS16825	COG0697	spore germination
CU648_RS16835	COG0681	Belongs to the peptidase S26 family
CU648_RS16845	COG0586	Pfam SNARE associated Golgi protein
CU648_RS16860	COG3871	stress protein (general stress protein 26)
CU648_RS16865	COG0387	Pfam Sodium calcium exchanger
CU648_RS16875	COG0535	radical SAM domain protein
CU648_RS16895	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CU648_RS16900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CU648_RS16915	COG3829	transcription factor binding
CU648_RS16925	COG0833	amino acid
CU648_RS16930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU648_RS16970	COG1263	PTS System
CU648_RS16970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_RS16975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU648_RS16995	COG0463	Glycosyl transferase, family 2
CU648_RS17005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU648_RS17005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CU648_RS17025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CU648_RS17045	COG1228	amidohydrolase
CU648_RS17050	COG1090	epimerase
CU648_RS17080	COG1988	membrane-bound metal-dependent
CU648_RS17085	COG1194	a g-specific adenine glycosylase
CU648_RS17110	COG1132	(ABC) transporter
CU648_RS17115	COG4129	membrane
CU648_RS17120	COG0069	glutamate synthase activity
CU648_RS17120	COG0067	glutamate synthase
CU648_RS17120	COG0070	glutamate synthase
CU648_RS17130	COG4555	ABC transporter
CU648_RS17150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CU648_RS17155	COG0735	belongs to the Fur family
CU648_RS17260	COG4974	Belongs to the 'phage' integrase family
CU648_RS17280	COG4695	Portal protein
CU648_RS17380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CU648_RS17385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CU648_RS17395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CU648_RS17405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CU648_RS17420	COG2766	serine protein kinase
CU648_RS17450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_RS17455	COG1126	abc transporter atp-binding protein
CU648_RS17460	COG0765	amino acid transport
CU648_RS17465	COG0765	amino acid transport
CU648_RS17470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU648_RS17480	COG1585	Membrane protein implicated in regulation of membrane protease activity
CU648_RS17485	COG2268	Band 7 protein
CU648_RS17495	COG3290	protein histidine kinase activity
CU648_RS17500	COG4565	transcriptional regulatory protein
CU648_RS17505	COG2851	Citrate transporter
CU648_RS17525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CU648_RS17530	COG3842	ATPase activity
CU648_RS17535	COG1175	transmembrane transport
CU648_RS17540	COG0395	ABC-type sugar transport system, permease component
CU648_RS17550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CU648_RS17555	COG0745	RESPONSE REGULATOR receiver
CU648_RS17560	COG5002	protein histidine kinase activity
CU648_RS17570	COG4990	cell redox homeostasis
CU648_RS17580	COG3290	protein histidine kinase activity
CU648_RS17585	COG4565	transcriptional regulatory protein
CU648_RS17590	COG3493	citrate carrier protein
CU648_RS17595	COG0281	malic enzyme
CU648_RS17610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_RS17620	COG5002	protein histidine kinase activity
CU648_RS17625	COG0745	RESPONSE REGULATOR receiver
CU648_RS17635	COG0454	-acetyltransferase
CU648_RS17635	COG0456	acetyltransferase
CU648_RS17640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CU648_RS17645	COG3383	formate dehydrogenase (NAD+) activity
CU648_RS17650	COG2427	Protein of unknown function (DUF1641)
CU648_RS17665	COG0531	amino acid
CU648_RS17675	COG0640	Transcriptional regulator
CU648_RS17680	COG2217	Heavy metal translocating P-type atpase
CU648_RS17685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CU648_RS17695	COG3227	Zinc metalloprotease (Elastase)
CU648_RS17715	COG2720	vancomycin resistance protein
CU648_RS17720	COG1316	TRANSCRIPTIONal
CU648_RS17725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_RS17730	COG0346	lactoylglutathione lyase activity
CU648_RS17735	COG1253	flavin adenine dinucleotide binding
CU648_RS17740	COG1027	Aspartate ammonia-lyase
CU648_RS17745	COG1620	l-lactate permease
CU648_RS17760	COG3104	oligopeptide transport
CU648_RS17765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_RS17770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS17775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_RS17790	COG0156	8-amino-7-oxononanoate synthase activity
CU648_RS17795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU648_RS17805	COG4548	von Willebrand factor, type A
CU648_RS17810	COG0714	Associated with various cellular activities
CU648_RS17815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_RS17835	COG0531	amino acid
CU648_RS17840	COG2188	Transcriptional regulator
CU648_RS17845	COG1263	PTS System
CU648_RS17845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_RS17850	COG0366	Alpha amylase catalytic
CU648_RS17865	COG0697	spore germination
CU648_RS17875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CU648_RS17880	COG1115	amino acid carrier protein
CU648_RS17885	COG1126	abc transporter atp-binding protein
CU648_RS17890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_RS17895	COG0765	amino acid transport
CU648_RS17900	COG0765	amino acid transport
CU648_RS17905	COG0833	amino acid
CU648_RS17930	COG2378	regulation of single-species biofilm formation
CU648_RS17935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CU648_RS17940	COG5002	protein histidine kinase activity
CU648_RS17955	COG0659	secondary active sulfate transmembrane transporter activity
CU648_RS17970	COG0747	negative chemotaxis
CU648_RS17980	COG0601	transmembrane transport
CU648_RS17985	COG4608	Belongs to the ABC transporter superfamily
CU648_RS17995	COG2271	Major facilitator Superfamily
CU648_RS18000	COG1846	Transcriptional regulator
CU648_RS18005	COG0477	Major facilitator Superfamily
CU648_RS18010	COG1609	Transcriptional regulator
CU648_RS18015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU648_RS18030	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU648_RS18035	COG1879	ABC-type sugar transport system periplasmic component
CU648_RS18060	COG1063	alcohol dehydrogenase
CU648_RS18075	COG3568	Endonuclease Exonuclease Phosphatase
CU648_RS18105	COG0840	transmembrane signaling receptor activity
CU648_RS18110	COG3584	3D domain protein
CU648_RS18110	COG1388	LysM domain
CU648_RS18115	COG1476	TRANSCRIPTIONal
CU648_RS18130	COG3104	oligopeptide transport
CU648_RS18135	COG1114	Component of the transport system for branched-chain amino acids
CU648_RS18150	COG1113	amino acid transport
CU648_RS18155	COG2252	PERMEase
CU648_RS18170	COG2153	protein acetylation
CU648_RS18180	COG0569	domain protein
CU648_RS18180	COG0475	glutathione-regulated potassium exporter activity
CU648_RS18195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU648_RS18200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CU648_RS18205	COG0833	amino acid
CU648_RS18210	COG4990	cell redox homeostasis
CU648_RS18225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU648_RS18230	COG0697	spore germination
CU648_RS18235	COG0531	amino acid
CU648_RS18250	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CU648_RS18255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CU648_RS18260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CU648_RS18260	COG1918	ferrous iron import across plasma membrane
CU648_RS18265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CU648_RS18270	COG0573	inorganic phosphate transmembrane transporter activity
CU648_RS18275	COG0581	inorganic phosphate transmembrane transporter activity
CU648_RS18285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU648_RS18405	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CU648_RS18430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CU648_RS18435	COG1116	anion transmembrane transporter activity
CU648_RS18440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU648_RS18445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU648_RS18450	COG0352	thiamine-phosphate diphosphorylase activity
CU648_RS18455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU648_RS18460	COG2104	thiamine diphosphate biosynthetic process
CU648_RS18470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU648_RS18475	COG0351	phosphomethylpyrimidine kinase
CU648_RS18520	COG2205	protein histidine kinase activity
CU648_RS18525	COG2814	Major facilitator Superfamily
CU648_RS18530	COG1846	Transcriptional regulator
CU648_RS18555	COG0577	efflux transmembrane transporter activity
CU648_RS18555	COG1136	(ABC) transporter
CU648_RS18565	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU648_RS18575	COG1879	ABC-type sugar transport system periplasmic component
CU648_RS18580	COG2252	PERMEase
CU648_RS18585	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS18605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_RS18645	COG0778	Nitroreductase
CU648_RS18650	COG2719	SpoVR family
CU648_RS18655	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU648_RS18660	COG1937	Protein conserved in bacteria
CU648_RS18665	COG0425	Belongs to the sulfur carrier protein TusA family
CU648_RS18665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_RS18670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS18670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_RS18675	COG0425	Belongs to the sulfur carrier protein TusA family
CU648_RS18685	COG0425	Belongs to the sulfur carrier protein TusA family
CU648_RS18685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_RS18695	COG2210	Belongs to the sulfur carrier protein TusA family
CU648_RS18700	COG0730	response to heat
CU648_RS18710	COG1316	TRANSCRIPTIONal
CU648_RS18715	COG0604	alcohol dehydrogenase
CU648_RS18720	COG1283	sodium-dependent phosphate transmembrane transporter activity
CU648_RS18735	COG3711	transcriptional antiterminator
CU648_RS18735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU648_RS18740	COG1447	Phosphotransferase system cellobiose-specific component IIA
CU648_RS18745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CU648_RS18770	COG3584	3D domain protein
CU648_RS18770	COG1388	LysM domain
CU648_RS18775	COG0577	efflux transmembrane transporter activity
CU648_RS18780	COG1136	(ABC) transporter
CU648_RS18790	COG5522	Integral membrane protein (intg_mem_TP0381)
CU648_RS18805	COG0577	efflux transmembrane transporter activity
CU648_RS18810	COG1114	Component of the transport system for branched-chain amino acids
CU648_RS18815	COG3546	catalase activity
CU648_RS18850	COG0586	Pfam SNARE associated Golgi protein
CU648_RS18885	COG0531	amino acid
CU648_RS18890	COG0475	glutathione-regulated potassium exporter activity
CU648_RS18900	COG1737	Transcriptional regulator
CU648_RS18910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_RS18910	COG1263	PTS System
CU648_RS18920	COG2259	Doxx family
CU648_RS18940	COG1522	sequence-specific DNA binding
CU648_RS18955	COG2076	Multidrug Resistance protein
CU648_RS18960	COG1309	transcriptional regulator
CU648_RS18965	COG2814	Major facilitator Superfamily
CU648_RS18970	COG4533	DNA binding
CU648_RS18975	COG2211	Major facilitator Superfamily
CU648_RS18985	COG0693	protein deglycase activity
CU648_RS18990	COG0693	protein deglycase activity
CU648_RS18990	COG0753	catalase activity
CU648_RS19000	COG0531	amino acid
CU648_RS19015	COG1012	belongs to the aldehyde dehydrogenase family
CU648_RS19035	COG1132	(ABC) transporter
CU648_RS19040	COG1132	(ABC) transporter
CU648_RS19050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_RS19055	COG0765	amino acid transport
CU648_RS19060	COG1126	abc transporter atp-binding protein
CU648_RS19075	COG0189	ligase activity
CU648_RS19100	COG4585	Histidine kinase
CU648_RS19145	COG0028	Belongs to the TPP enzyme family
CU648_RS19150	COG3527	Alpha-acetolactate decarboxylase
CU648_RS19165	COG0561	phosphatase activity
CU648_RS19175	COG3409	Peptidoglycan-binding domain 1 protein
CU648_RS19175	COG5632	N-Acetylmuramoyl-L-alanine amidase
CU648_RS19185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CU648_RS19205	COG0659	secondary active sulfate transmembrane transporter activity
CU648_RS19225	COG0653	protein targeting
CU648_RS19230	COG2244	polysaccharide biosynthetic process
CU648_RS19240	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU648_RS19245	COG4196	transglutaminase domain protein
CU648_RS19265	COG1024	Enoyl-CoA hydratase
CU648_RS19285	COG1363	Peptidase, m42
CU648_RS19305	COG3938	Belongs to the proline racemase family
CU648_RS19315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CU648_RS19320	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CU648_RS19340	COG0601	transmembrane transport
CU648_RS19345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU648_RS19350	COG0444	Belongs to the ABC transporter superfamily
CU648_RS19355	COG4608	Belongs to the ABC transporter superfamily
CU648_RS19365	COG0477	Major facilitator Superfamily
CU648_RS19370	COG3290	protein histidine kinase activity
CU648_RS19375	COG4565	transcriptional regulatory protein
CU648_RS19380	COG3181	Tripartite tricarboxylate transporter family receptor
CU648_RS19425	COG0210	DNA helicase
CU648_RS19470	COG4978	Transcriptional regulator
CU648_RS19470	COG0789	Transcriptional regulator
CU648_RS19485	COG0305	Participates in initiation and elongation during chromosome replication
CU648_RS19585	COG1183	phosphatidylcholine synthase activity
CU648_RS19620	COG2376	Dihydroxyacetone kinase
CU648_RS19635	COG2376	Dihydroxyacetone kinase
CU648_RS19640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CU648_RS19645	COG1959	2 iron, 2 sulfur cluster binding
CU648_RS19680	COG0457	Tetratricopeptide repeat
CU648_RS19695	COG2770	Histidine kinase
CU648_RS19695	COG3437	response regulator, receiver
CU648_RS19710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU648_RS19795	COG1136	(ABC) transporter
CU648_RS19860	COG1191	sigma factor activity
CU648_RS19870	COG2208	phosphoserine phosphatase activity
CU648_RS19875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CU648_RS19880	COG2198	Histidine kinase
CU648_RS19880	COG2205	protein histidine kinase activity
CU648_RS19880	COG0784	Response regulator, receiver
CU648_RS19880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_RS19940	COG0420	3'-5' exonuclease activity
CU648_RS19945	COG4717	serine-type aminopeptidase activity
CU648_RS19975	COG0346	lactoylglutathione lyase activity
CU648_RS19980	COG0346	lactoylglutathione lyase activity
CU648_RS19985	COG0457	Tetratricopeptide repeat
CU648_RS19995	COG2267	carboxylic ester hydrolase activity
CU648_RS20025	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CU648_RS20030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CU648_RS20040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CU648_RS20085	COG0477	Major facilitator Superfamily
CU648_RS20090	COG0477	Major facilitator Superfamily
CU648_RS20100	COG3973	AAA domain
CU648_RS20105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU648_RS20130	COG4980	gas vesicle protein
CU648_RS20135	COG0537	adenosine 5'-monophosphoramidase activity
CU648_RS20145	COG1131	(ABC) transporter
CU648_RS20150	COG4473	ABC transporter
CU648_RS20210	COG1309	transcriptional regulator
CU648_RS20220	COG3402	PFAM membrane-flanked domain
CU648_RS20225	COG3428	Bacterial PH domain
CU648_RS20265	COG3402	PFAM membrane-flanked domain
CU648_RS20270	COG3428	Bacterial PH domain
CU648_RS20275	COG2329	Antibiotic biosynthesis monooxygenase
CU648_RS20280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_RS20295	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CU648_RS20325	COG1309	transcriptional regulator
CU648_RS20330	COG1511	domain protein
CU648_RS20350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_RS20355	COG1609	Transcriptional regulator
CU648_RS20365	COG1234	tRNA 3'-trailer cleavage
CU648_RS20370	COG0095	Lipoate-protein ligase
CU648_RS20380	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_RS20415	COG1408	metallophosphoesterase
CU648_RS20425	COG1078	dGTPase activity
CU648_RS20430	COG1129	ABC transporter
CU648_RS20455	COG0477	Major facilitator Superfamily
CU648_RS20465	COG1595	DNA-templated transcription, initiation
CU648_RS20470	COG3708	Transcriptional regulator
CU648_RS20470	COG2207	Transcriptional regulator
CU648_RS20485	COG2205	protein histidine kinase activity
CU648_RS20490	COG0745	RESPONSE REGULATOR receiver
CU648_RS20515	COG0501	Belongs to the peptidase M48B family
CU648_RS20520	COG0697	spore germination
CU648_RS20540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CU648_RS20545	COG2224	Isocitrate lyase
CU648_RS20570	COG4903	ComK protein
CU648_RS20575	COG0398	Pfam SNARE associated Golgi protein
CU648_RS20635	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU648_RS20660	COG0367	asparagine synthase
CU648_RS20670	COG0753	catalase activity
CU648_RS20675	COG0004	ammonium transporteR
CU648_RS20695	COG2996	Protein conserved in bacteria
CU648_RS20700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU648_RS20710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS20725	COG0561	phosphatase activity
CU648_RS20740	COG0542	response to heat
CU648_RS20750	COG2267	carboxylic ester hydrolase activity
CU648_RS20770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_RS20775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CU648_RS20780	COG5504	Zn-dependent protease
CU648_RS20795	COG0180	Tryptophanyl-tRNA synthetase
CU648_RS20810	COG4166	transmembrane transport
CU648_RS20815	COG0601	transmembrane transport
CU648_RS20820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU648_RS20825	COG0444	Belongs to the ABC transporter superfamily
CU648_RS20830	COG4608	Belongs to the ABC transporter superfamily
CU648_RS20835	COG0534	Mate efflux family protein
CU648_RS20840	COG4166	transmembrane transport
CU648_RS20870	COG0861	Integral membrane protein TerC family
CU648_RS20875	COG4862	establishment of competence for transformation
CU648_RS20880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_RS20890	COG1164	Oligoendopeptidase f
CU648_RS20905	COG2346	COG2346, Truncated hemoglobins
CU648_RS20910	COG4116	CYTH
CU648_RS20920	COG2357	RelA SpoT domain protein
CU648_RS20930	COG0564	pseudouridine synthase activity
CU648_RS20945	COG0772	Belongs to the SEDS family
CU648_RS20950	COG1216	Glycosyl transferase, family 2
CU648_RS20970	COG0457	Tetratricopeptide repeat
CU648_RS20970	COG0463	Glycosyl transferase, family 2
CU648_RS20990	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CU648_RS21005	COG1091	dTDP-4-dehydrorhamnose reductase activity
CU648_RS21050	COG2153	protein acetylation
CU648_RS21060	COG2382	esterase
CU648_RS21075	COG5492	domain, Protein
CU648_RS21080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU648_RS21095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CU648_RS21095	COG0512	Glutamine amidotransferase of anthranilate synthase
CU648_RS21130	COG1620	l-lactate permease
CU648_RS21135	COG5634	Uncharacterized conserved protein (DUF2278)
CU648_RS21195	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU648_RS21205	COG1476	TRANSCRIPTIONal
CU648_RS21295	COG2226	methyltransferase
CU648_RS21310	COG1686	Belongs to the peptidase S11 family
CU648_RS21315	COG0681	Belongs to the peptidase S26 family
CU648_RS21350	COG1012	belongs to the aldehyde dehydrogenase family
CU648_RS21360	COG1176	ABC-type spermidine putrescine transport system, permease component I
CU648_RS21365	COG1177	transmembrane transport
CU648_RS21370	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CU648_RS21380	COG2409	Drug exporters of the RND superfamily
CU648_RS21390	COG0564	pseudouridine synthase activity
CU648_RS21400	COG2340	Cysteine-rich secretory protein family
CU648_RS21405	COG0247	lactate metabolic process
CU648_RS21410	COG0277	FAD linked oxidase domain protein
CU648_RS21415	COG3835	regulator
CU648_RS21425	COG0745	RESPONSE REGULATOR receiver
CU648_RS21430	COG5002	protein histidine kinase activity
CU648_RS21435	COG2186	Transcriptional regulator
CU648_RS21455	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CU648_RS21465	COG2116	formate transmembrane transporter activity
CU648_RS21470	COG0861	Integral membrane protein TerC family
CU648_RS21475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CU648_RS21485	COG2030	dehydratase
CU648_RS21505	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS21510	COG3243	poly(R)-hydroxyalkanoic acid synthase
CU648_RS21515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU648_RS21520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CU648_RS21540	COG1840	ABC-type Fe3 transport system, periplasmic component
CU648_RS21545	COG3842	ATPase activity
CU648_RS21570	COG1349	DNA-binding transcription factor activity
CU648_RS21585	COG0235	Class ii aldolase
CU648_RS21595	COG2861	carbohydrate metabolic process
CU648_RS21605	COG3852	Histidine kinase
CU648_RS21610	COG1846	Transcriptional regulator
CU648_RS21620	COG2318	DinB family
CU648_RS21630	COG5002	protein histidine kinase activity
CU648_RS21640	COG0720	synthase
CU648_RS21655	COG4873	Protein conserved in bacteria
CU648_RS21690	COG1780	Probably involved in ribonucleotide reductase function
CU648_RS21700	COG1403	HNH endonuclease
CU648_RS21710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU648_RS21715	COG1725	Transcriptional regulator
CU648_RS21720	COG1131	(ABC) transporter
CU648_RS21730	COG1131	(ABC) transporter
CU648_RS21735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CU648_RS21750	COG1522	sequence-specific DNA binding
CU648_RS21760	COG1335	isochorismatase
CU648_RS21770	COG1619	proteins homologs of microcin C7 resistance protein MccF
CU648_RS21775	COG2070	2-Nitropropane dioxygenase
CU648_RS21780	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CU648_RS21790	COG1696	Membrane protein involved in D-alanine export
CU648_RS21815	COG0716	FMN binding
CU648_RS21830	COG3173	Aminoglycoside phosphotransferase
CU648_RS21855	COG0534	Mate efflux family protein
CU648_RS21860	COG1968	undecaprenyl-diphosphatase activity
CU648_RS21875	COG1846	Transcriptional regulator
CU648_RS21885	COG1301	dicarboxylic acid transport
CU648_RS21890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CU648_RS21895	COG4709	membrane
CU648_RS21900	COG3874	Sporulation protein YtfJ
CU648_RS21930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU648_RS21935	COG0028	Belongs to the TPP enzyme family
CU648_RS21940	COG0440	acetolactate synthase activity
CU648_RS21980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CU648_RS22015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CU648_RS22030	COG1183	phosphatidylcholine synthase activity
CU648_RS22035	COG1368	sulfuric ester hydrolase activity
CU648_RS22045	COG0019	diaminopimelate decarboxylase activity
CU648_RS22065	COG0529	Catalyzes the synthesis of activated sulfate
CU648_RS22070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU648_RS22090	COG1648	precorrin-2 dehydrogenase activity
CU648_RS22100	COG0733	neurotransmitter:sodium symporter activity
CU648_RS22120	COG1757	Na H antiporter
CU648_RS22135	COG4758	membrane
CU648_RS22140	COG4585	Histidine kinase
CU648_RS22145	COG2197	response regulator
CU648_RS22155	COG1114	Component of the transport system for branched-chain amino acids
CU648_RS22165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU648_RS22210	COG0730	response to heat
CU648_RS22215	COG0306	phosphate transporter
CU648_RS22220	COG1392	Phosphate transport regulator
CU648_RS22225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_RS22240	COG3852	Histidine kinase
CU648_RS22245	COG1801	Protein of unknown function DUF72
CU648_RS22255	COG0582	viral genome integration into host DNA
CU648_RS22260	COG5002	protein histidine kinase activity
CU648_RS22275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CU648_RS22275	COG0392	lysyltransferase activity
CU648_RS22290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CU648_RS22295	COG1686	Belongs to the peptidase S11 family
CU648_RS22300	COG2715	membrane protein required for spore maturation
CU648_RS22305	COG0700	Nucleoside recognition
CU648_RS22310	COG1187	pseudouridine synthase activity
CU648_RS22320	COG1333	cytochrome c biogenesis protein
CU648_RS22325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU648_RS22330	COG0745	RESPONSE REGULATOR receiver
CU648_RS22335	COG5002	protein histidine kinase activity
CU648_RS22340	COG2096	Adenosyltransferase
CU648_RS22345	COG4942	peptidase
CU648_RS22355	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CU648_RS22360	COG1141	Ferredoxin
CU648_RS22370	COG0514	ATP-dependent DNA helicase (RecQ)
CU648_RS22375	COG1266	CAAX protease self-immunity
CU648_RS22385	COG1408	metallophosphoesterase
CU648_RS22395	COG4862	establishment of competence for transformation
CU648_RS22400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CU648_RS22420	COG0492	ferredoxin-NADP+ reductase activity
CU648_RS22495	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CU648_RS22510	COG0142	geranyltranstransferase activity
CU648_RS22520	COG0142	geranyltranstransferase activity
CU648_RS22545	COG0457	Tetratricopeptide repeat
CU648_RS22565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CU648_RS22580	COG4347	Protein of unknown function (DUF1405)
CU648_RS22595	COG2738	Putative neutral zinc metallopeptidase
CU648_RS22605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS22615	COG1694	Mazg nucleotide pyrophosphohydrolase
CU648_RS22630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU648_RS22635	COG0438	transferase activity, transferring glycosyl groups
CU648_RS22675	COG1199	ATP-dependent helicase activity
CU648_RS22675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CU648_RS22695	COG3935	DnaD domain protein
CU648_RS22700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CU648_RS22710	COG4499	WXG100 protein secretion system (Wss), protein YukC
CU648_RS22710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_RS22770	COG0116	Belongs to the methyltransferase superfamily
CU648_RS22780	COG1199	ATP-dependent helicase activity
CU648_RS22785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CU648_RS22795	COG3173	Aminoglycoside phosphotransferase
CU648_RS22800	COG0024	Methionine aminopeptidase
CU648_RS22810	COG2233	PERMEase
CU648_RS22815	COG2311	Membrane
CU648_RS22825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CU648_RS22835	COG0456	acetyltransferase
CU648_RS22880	COG0754	glutathionylspermidine amidase activity
CU648_RS22895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU648_RS22910	COG0454	-acetyltransferase
CU648_RS22930	COG0328	RNA-DNA hybrid ribonuclease activity
CU648_RS22970	COG1280	lysine exporter protein (LysE YggA)
CU648_RS22985	COG3162	membrane
CU648_RS22990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU648_RS22995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU648_RS23010	COG0475	glutathione-regulated potassium exporter activity
CU648_RS23015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU648_RS23030	COG1196	nuclear chromosome segregation
CU648_RS23065	COG0640	Transcriptional regulator
CU648_RS23090	COG0640	Transcriptional regulator
CU648_RS23095	COG0798	PFAM Bile acid sodium symporter
CU648_RS23125	COG0789	Transcriptional regulator
CU648_RS23125	COG4978	Transcriptional regulator
CU648_RS23135	COG2323	membrane
CU648_RS23140	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CU648_RS23195	COG1923	regulation of RNA biosynthetic process
CU648_RS23205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CU648_RS23210	COG1360	Flagellar Motor Protein
CU648_RS23215	COG2201	protein-glutamate methylesterase activity
CU648_RS23220	COG0643	Histidine kinase
CU648_RS23220	COG2198	Histidine kinase
CU648_RS23225	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU648_RS23225	COG1776	CheC inhibitor of MCP methylation
CU648_RS23240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CU648_RS23260	COG1256	bacterial-type flagellum assembly
CU648_RS23265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU648_RS23285	COG1815	bacterial-type flagellum-dependent cell motility
CU648_RS23290	COG1558	bacterial-type flagellum-dependent cell motility
CU648_RS23300	COG1766	The M ring may be actively involved in energy transduction
CU648_RS23305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU648_RS23315	COG1157	protein secretion by the type III secretion system
CU648_RS23335	COG1749	Flagellar hook protein flgE
CU648_RS23350	COG0835	chemotaxis
CU648_RS23350	COG0784	Response regulator, receiver
CU648_RS23360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU648_RS23365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU648_RS23365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU648_RS23370	COG0741	lytic transglycosylase activity
CU648_RS23380	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU648_RS23385	COG1776	CheC inhibitor of MCP methylation
CU648_RS23385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU648_RS23395	COG1338	Plays a role in the flagellum-specific transport system
CU648_RS23400	COG1987	bacterial-type flagellum assembly
CU648_RS23410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CU648_RS23415	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CU648_RS23420	COG1419	protein localization to endoplasmic reticulum
CU648_RS23425	COG4786	Flagellar basal body rod
CU648_RS23430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CU648_RS23455	COG1309	transcriptional regulator
CU648_RS23485	COG2329	Antibiotic biosynthesis monooxygenase
CU648_RS23510	COG0583	DNA-binding transcription factor activity
CU648_RS23515	COG3842	ATPase activity
CU648_RS23520	COG0725	ABC transporter, periplasmic molybdate-binding protein
CU648_RS23530	COG1234	tRNA 3'-trailer cleavage
CU648_RS23560	COG1686	Belongs to the peptidase S11 family
CU648_RS23565	COG0406	alpha-ribazole phosphatase activity
CU648_RS23580	COG1846	Transcriptional regulator
CU648_RS23590	COG0367	asparagine synthase
CU648_RS23620	COG1802	Transcriptional regulator
CU648_RS23625	COG0697	spore germination
CU648_RS23630	COG0523	cobalamin synthesis protein
CU648_RS23640	COG0701	Predicted permease
CU648_RS23655	COG1757	Na H antiporter
CU648_RS23660	COG0114	fumarate hydratase activity
CU648_RS23675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS23685	COG0534	Mate efflux family protein
CU648_RS23695	COG3340	Belongs to the peptidase S51 family
CU648_RS23715	COG0785	Cytochrome C biogenesis protein
CU648_RS23745	COG2733	membrane
CU648_RS23785	COG1131	(ABC) transporter
CU648_RS23800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_RS23805	COG0528	UMP kinase activity
CU648_RS23815	COG1027	Aspartate ammonia-lyase
CU648_RS23820	COG0281	malic enzyme
CU648_RS23825	COG4191	Histidine kinase
CU648_RS23830	COG0784	Response regulator, receiver
CU648_RS23835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU648_RS23860	COG3620	sequence-specific DNA binding
CU648_RS23895	COG1051	belongs to the nudix hydrolase family
CU648_RS23910	COG2814	Major facilitator Superfamily
CU648_RS23925	COG1966	Carbon starvation protein
CU648_RS23935	COG1695	Transcriptional regulator
CU648_RS23945	COG0477	Major facilitator Superfamily
CU648_RS23950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_RS23960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CU648_RS23965	COG4166	transmembrane transport
CU648_RS23970	COG2223	nitrite transmembrane transporter activity
CU648_RS23975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU648_RS23990	COG2244	polysaccharide biosynthetic process
CU648_RS23995	COG0733	neurotransmitter:sodium symporter activity
CU648_RS24005	COG5566	PFAM Mor transcription activator
CU648_RS24010	COG2323	membrane
CU648_RS24035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU648_RS24040	COG2132	Multicopper oxidase
CU648_RS24050	COG5002	protein histidine kinase activity
CU648_RS24055	COG0745	RESPONSE REGULATOR receiver
CU648_RS24065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU648_RS24070	COG0028	Belongs to the TPP enzyme family
CU648_RS24075	COG0440	acetolactate synthase activity
CU648_RS24080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CU648_RS24090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CU648_RS24115	COG2814	Major facilitator Superfamily
CU648_RS24120	COG3384	dioxygenase
CU648_RS24130	COG3279	Response regulator of the LytR AlgR family
CU648_RS24135	COG0427	acetyl-CoA hydrolase
CU648_RS24170	COG4166	transmembrane transport
CU648_RS24215	COG0535	radical SAM domain protein
CU648_RS24220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_RS24240	COG1914	H( )-stimulated, divalent metal cation uptake system
CU648_RS24275	COG0531	amino acid
CU648_RS24310	COG2390	Transcriptional regulator
CU648_RS24320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_RS24325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CU648_RS24335	COG4846	Membrane protein involved in cytochrome C biogenesis
CU648_RS24360	COG0006	proline dipeptidase activity
CU648_RS24365	COG2132	Multicopper oxidase
CU648_RS24380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CU648_RS24415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CU648_RS24420	COG1114	Component of the transport system for branched-chain amino acids
CU648_RS24430	COG2372	response to copper ion
CU648_RS24430	COG1276	copper resistance
CU648_RS24435	COG4549	nuclear export factor GLE1
CU648_RS24445	COG0697	spore germination
CU648_RS24450	COG0583	DNA-binding transcription factor activity
CU648_RS24455	COG1959	2 iron, 2 sulfur cluster binding
CU648_RS24460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU648_RS24465	COG0778	Nitroreductase
CU648_RS24480	COG0628	permease
CU648_RS24490	COG1231	oxidoreductase activity
CU648_RS24495	COG0523	cobalamin synthesis protein
CU648_RS24510	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_RS24515	COG2030	dehydratase
CU648_RS24520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_RS24535	COG0411	ABC transporter
CU648_RS24555	COG0583	DNA-binding transcription factor activity
CU648_RS24585	COG1271	oxidase subunit
CU648_RS24590	COG1294	oxidase, subunit
CU648_RS24595	COG4988	ABC transporter
CU648_RS24600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CU648_RS24620	COG1686	Belongs to the peptidase S11 family
CU648_RS24635	COG0791	NLP P60 protein
CU648_RS24635	COG1388	LysM domain
CU648_RS24645	COG1132	(ABC) transporter
CU648_RS24650	COG0745	RESPONSE REGULATOR receiver
CU648_RS24655	COG5002	protein histidine kinase activity
CU648_RS24665	COG0300	oxidoreductase activity
CU648_RS24670	COG4122	O-methyltransferase activity
CU648_RS24685	COG5658	integral membrane protein
CU648_RS24705	COG0460	homoserine dehydrogenase
CU648_RS24730	COG1316	TRANSCRIPTIONal
CU648_RS24740	COG0745	RESPONSE REGULATOR receiver
CU648_RS24745	COG5002	protein histidine kinase activity
CU648_RS24760	COG1285	pathogenesis
CU648_RS24765	COG1247	-acetyltransferase
CU648_RS24785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CU648_RS24795	COG1082	Xylose isomerase domain protein TIM barrel
CU648_RS24805	COG2814	Major facilitator Superfamily
CU648_RS24810	COG1279	arginine transmembrane transporter activity
CU648_RS24825	COG1752	Esterase of the alpha-beta hydrolase superfamily
CU648_RS24860	COG0577	efflux transmembrane transporter activity
CU648_RS24865	COG2002	toxin-antitoxin pair type II binding
CU648_RS24870	COG1404	Belongs to the peptidase S8 family
CU648_RS24875	COG0640	Transcriptional regulator
CU648_RS24880	COG0667	Aldo Keto reductase
CU648_RS24885	COG2814	Major facilitator Superfamily
CU648_RS24910	COG0840	transmembrane signaling receptor activity
CU648_RS24930	COG3949	Membrane
CU648_RS24935	COG0783	Belongs to the Dps family
CU648_RS24950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU648_RS24960	COG1231	oxidoreductase activity
CU648_RS24970	COG4989	oxidoreductase activity
CU648_RS24975	COG0523	cobalamin synthesis protein
CU648_RS24980	COG0456	acetyltransferase
CU648_RS24995	COG3443	Belongs to the bacterial solute-binding protein 9 family
CU648_RS24995	COG0803	Belongs to the bacterial solute-binding protein 9 family
CU648_RS25005	COG0702	epimerase
CU648_RS25015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CU648_RS25025	COG4166	transmembrane transport
CU648_RS25040	COG0406	alpha-ribazole phosphatase activity
CU648_RS25050	COG5337	Spore coat protein CotH
CU648_RS25055	COG1051	belongs to the nudix hydrolase family
CU648_RS25060	COG0586	Pfam SNARE associated Golgi protein
CU648_RS25065	COG2244	polysaccharide biosynthetic process
CU648_RS25075	COG0701	Predicted permease
CU648_RS25080	COG3689	TIGRFAM TIGR03943 family protein
CU648_RS25085	COG1607	acyl-coa hydrolase
CU648_RS25095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_RS25110	COG0702	epimerase
CU648_RS25115	COG2839	Protein conserved in bacteria
CU648_RS25120	COG1253	flavin adenine dinucleotide binding
CU648_RS25135	COG1114	Component of the transport system for branched-chain amino acids
CU648_RS25140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU648_RS25160	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU648_RS25170	COG1876	peptidase activity
CU648_RS25180	COG0154	amidase activity
CU648_RS25185	COG2211	Major facilitator Superfamily
CU648_RS25205	COG0561	phosphatase activity
CU648_RS25215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CU648_RS25235	COG1819	glycosyl
CU648_RS25240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_RS25245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_RS25275	COG0456	acetyltransferase
CU648_RS25310	COG3874	Sporulation protein YtfJ
CU648_RS25335	COG2226	methyltransferase
CU648_RS25355	COG1082	Xylose isomerase domain protein TIM barrel
CU648_RS25360	COG0346	lactoylglutathione lyase activity
CU648_RS25370	COG0604	alcohol dehydrogenase
CU648_RS25375	COG1595	DNA-templated transcription, initiation
CU648_RS25410	COG0386	Belongs to the glutathione peroxidase family
CU648_RS25415	COG1305	Transglutaminase-like
CU648_RS25420	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CU648_RS25425	COG0714	Associated with various cellular activities
CU648_RS25440	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CU648_RS25445	COG1140	nitrate reductase beta subunit
CU648_RS25450	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CU648_RS25455	COG2181	nitrate reductase activity
CU648_RS25460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU648_RS25465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CU648_RS25470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU648_RS25475	COG0303	'Molybdopterin
CU648_RS25480	COG0314	molybdopterin synthase activity
CU648_RS25490	COG2223	nitrite transmembrane transporter activity
CU648_RS25500	COG1648	precorrin-2 dehydrogenase activity
CU648_RS25510	COG1587	Uroporphyrinogen-III synthase
CU648_RS25510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CU648_RS25515	COG2146	nitrite reductase [NAD(P)H] activity
CU648_RS25520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU648_RS25525	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CU648_RS25550	COG2359	stage V sporulation protein S
CU648_RS25595	COG1418	mRNA catabolic process
CU648_RS25600	COG0488	(ABC) transporter
CU648_RS25615	COG0629	single-stranded DNA binding
CU648_RS25620	COG1413	lyase activity
CU648_RS25635	COG2521	methyltransferase
CU648_RS25635	COG2136	Putative SAM-dependent methyltransferase
CU648_RS25675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CU648_RS25685	COG0017	Asparaginyl-tRNA synthetase
CU648_RS25705	COG1674	ftsk spoiiie
CU648_RS25760	COG1929	Belongs to the glycerate kinase type-1 family
CU648_RS25765	COG0471	metal ion transport
CU648_RS25770	COG0745	RESPONSE REGULATOR receiver
CU648_RS25775	COG3850	Histidine kinase
CU648_RS25775	COG5002	protein histidine kinase activity
CU648_RS25790	COG0733	neurotransmitter:sodium symporter activity
CU648_RS25815	COG2610	gluconate transmembrane transporter activity
CU648_RS25820	COG1454	alcohol dehydrogenase
CU648_RS25825	COG1794	racemase activity, acting on amino acids and derivatives
CU648_RS25835	COG0456	acetyltransferase
CU648_RS25840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CU648_RS25850	COG1131	(ABC) transporter
CU648_RS25855	COG4473	ABC transporter
CU648_RS25865	COG0546	phosphoglycolate phosphatase activity
CU648_RS25885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU648_RS25890	COG3250	beta-galactosidase activity
CU648_RS25905	COG0768	penicillin binding
CU648_RS25915	COG0204	Acyl-transferase
CU648_RS25920	COG1272	protein, Hemolysin III
CU648_RS25930	COG0805	protein transport
CU648_RS25945	COG1307	EDD domain protein, DegV family
CU648_RS25950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CU648_RS25955	COG1999	signal sequence binding
CU648_RS25960	COG0071	Belongs to the small heat shock protein (HSP20) family
CU648_RS25965	COG0367	asparagine synthase
CU648_RS25990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_RS25995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU648_RS26015	COG1335	isochorismatase
CU648_RS26020	COG1051	belongs to the nudix hydrolase family
CU648_RS26025	COG0071	Belongs to the small heat shock protein (HSP20) family
CU648_RS26030	COG0668	transmembrane transport
CU648_RS26035	COG2203	Gaf domain
CU648_RS26035	COG4585	Histidine kinase
CU648_RS26040	COG2197	response regulator
CU648_RS26050	COG1064	alcohol dehydrogenase
CU648_RS26075	COG1070	Carbohydrate kinase
CU648_RS26080	COG1070	Carbohydrate kinase
CU648_RS26110	COG0517	IMP dehydrogenase activity
CU648_RS26110	COG1125	glycine betaine transport
CU648_RS26115	COG1174	glycine betaine transport
CU648_RS26150	COG1253	flavin adenine dinucleotide binding
CU648_RS26155	COG1012	belongs to the aldehyde dehydrogenase family
CU648_RS26160	COG5506	Protein of unknown function (DUF1694)
CU648_RS26180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU648_RS26185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CU648_RS26190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CU648_RS26195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU648_RS26200	COG0456	acetyltransferase
CU648_RS26205	COG3829	transcription factor binding
CU648_RS26215	COG1509	lysine 2,3-aminomutase activity
CU648_RS26255	COG4326	sporulation control protein
CU648_RS26260	COG0671	phosphoesterase, PA-phosphatase related
CU648_RS26265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CU648_RS26270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_RS26350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU648_RS26385	COG0300	oxidoreductase activity
CU648_RS26405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_RS26405	COG4499	WXG100 protein secretion system (Wss), protein YukC
CU648_RS26410	COG2814	Major facilitator Superfamily
CU648_RS26415	COG4841	protein insertion into membrane
CU648_RS26420	COG0372	Belongs to the citrate synthase family
CU648_RS26425	COG2079	MmgE PrpD family protein
CU648_RS26430	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CU648_RS26435	COG1960	acyl-CoA dehydrogenase activity
CU648_RS26440	COG2084	Dehydrogenase
CU648_RS26450	COG1280	lysine exporter protein (LysE YggA)
CU648_RS26455	COG1024	Enoyl-CoA hydratase
CU648_RS26470	COG0420	3'-5' exonuclease activity
CU648_RS26475	COG0419	ATPase involved in DNA repair
CU648_RS26505	COG2223	nitrite transmembrane transporter activity
CU648_RS26515	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_RS26520	COG1169	isochorismate synthase
CU648_RS26525	COG1021	2,3-dihydroxybenzoate-AMP ligase
CU648_RS26530	COG1535	isochorismatase
CU648_RS26530	COG3433	isochorismatase activity
CU648_RS26535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU648_RS26540	COG3251	PFAM MbtH domain protein
CU648_RS26545	COG2814	Major facilitator Superfamily
CU648_RS26560	COG0776	regulation of translation
CU648_RS26570	COG2318	DinB family
CU648_RS26580	COG1115	amino acid carrier protein
CU648_RS26595	COG2329	Antibiotic biosynthesis monooxygenase
CU648_RS26600	COG1187	pseudouridine synthase activity
CU648_RS26605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CU648_RS26610	COG1136	(ABC) transporter
CU648_RS26625	COG0596	Alpha beta hydrolase
CU648_RS26630	COG2814	Major facilitator Superfamily
CU648_RS26650	COG2226	methyltransferase
CU648_RS26685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS26720	COG1247	-acetyltransferase
CU648_RS26730	COG0640	Transcriptional regulator
CU648_RS26750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU648_RS26755	COG0589	response to stress
CU648_RS26760	COG0659	secondary active sulfate transmembrane transporter activity
CU648_RS26770	COG1695	Transcriptional regulator
CU648_RS26780	COG0640	Transcriptional regulator
CU648_RS26785	COG0798	PFAM Bile acid sodium symporter
CU648_RS26855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CU648_RS26865	COG2226	methyltransferase
CU648_RS26870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_RS26880	COG1278	Cold shock
CU648_RS26895	COG0010	Belongs to the arginase family
CU648_RS26905	COG0583	DNA-binding transcription factor activity
CU648_RS26910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CU648_RS26925	COG0583	DNA-binding transcription factor activity
CU648_RS26930	COG2258	MOSC domain
CU648_RS26945	COG1132	(ABC) transporter
CU648_RS26950	COG1132	(ABC) transporter
CU648_RS26970	COG1396	sequence-specific DNA binding
CU648_RS27000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CU648_RS27010	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CU648_RS27015	COG1595	DNA-templated transcription, initiation
CU648_RS27045	COG1649	PFAM Uncharacterised BCR, COG1649
CU648_RS27075	COG2971	BadF BadG BcrA BcrD
CU648_RS27085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CU648_RS27150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_RS27180	COG1309	transcriptional regulator
CU648_RS27195	COG0577	efflux transmembrane transporter activity
CU648_RS27195	COG1136	(ABC) transporter
CU648_RS27200	COG3615	Tellurite resistance protein tehB
CU648_RS27200	COG0500	methyltransferase
CU648_RS27210	COG3961	Belongs to the TPP enzyme family
CU648_RS27215	COG1846	Transcriptional regulator
CU648_RS27250	COG2195	Cleaves the N-terminal amino acid of tripeptides
CU648_RS27265	COG1595	DNA-templated transcription, initiation
CU648_RS27275	COG0768	penicillin binding
CU648_RS27280	COG0768	penicillin binding
CU648_RS27285	COG2367	Beta-lactamase
CU648_RS27290	COG1408	metallophosphoesterase
CU648_RS27325	COG1960	acyl-CoA dehydrogenase activity
CU648_RS27330	COG0439	Biotin carboxylase
CU648_RS27335	COG0511	ligase activity, forming carbon-carbon bonds
CU648_RS27340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU648_RS27345	COG1024	Enoyl-CoA hydratase
CU648_RS27350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU648_RS27355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU648_RS27365	COG1247	-acetyltransferase
CU648_RS27370	COG0572	uridine kinase
CU648_RS27375	COG2318	DinB family
CU648_RS27380	COG1686	Belongs to the peptidase S11 family
CU648_RS27405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CU648_RS27425	COG3227	Zinc metalloprotease (Elastase)
CU648_RS27445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU648_RS27445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU648_RS27510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_RS27530	COG1063	alcohol dehydrogenase
CU648_RS27555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CU648_RS27570	COG3773	Cell wall hydrolase
CU648_RS27580	COG0745	RESPONSE REGULATOR receiver
CU648_RS27585	COG2205	protein histidine kinase activity
CU648_RS27595	COG0488	(ABC) transporter
CU648_RS27605	COG1136	(ABC) transporter
CU648_RS27610	COG0577	efflux transmembrane transporter activity
CU648_RS27630	COG0460	homoserine dehydrogenase
CU648_RS27635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_RS27645	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CU648_RS27745	COG2124	cytochrome p450
CU648_RS27780	COG0561	phosphatase activity
CU648_RS27815	COG5002	protein histidine kinase activity
CU648_RS27820	COG0768	penicillin binding
CU648_RS27825	COG1819	glycosyl
CU648_RS27830	COG1794	racemase activity, acting on amino acids and derivatives
CU648_RS27855	COG2205	protein histidine kinase activity
CU648_RS27865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU648_RS27870	COG0604	alcohol dehydrogenase
CU648_RS27875	COG0671	phosphoesterase, PA-phosphatase related
CU648_RS27880	COG0768	penicillin binding
CU648_RS27895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU648_RS27930	COG0693	protein deglycase activity
CU648_RS27960	COG2814	Major facilitator Superfamily
CU648_RS27980	COG0584	glycerophosphoryl diester phosphodiesterase
CU648_RS28000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_RS28005	COG0697	spore germination
CU648_RS28035	COG2223	nitrite transmembrane transporter activity
CU648_RS28040	COG2816	NAD+ diphosphatase activity
CU648_RS28045	COG0592	DNA-directed DNA polymerase activity
CU648_RS28050	COG2816	NAD+ diphosphatase activity
CU648_RS28080	COG3878	Protein conserved in bacteria
CU648_RS28100	COG4667	esterase of the alpha-beta hydrolase superfamily
CU648_RS28125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU648_RS28140	COG0322	excinuclease ABC activity
CU648_RS28185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU648_RS28210	COG1011	Hydrolase
CU648_RS28235	COG1523	belongs to the glycosyl hydrolase 13 family
CU648_RS28240	COG3227	Zinc metalloprotease (Elastase)
CU648_RS28260	COG0201	protein transport