locus-tag	class	description
KH172YL63_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KH172YL63_RS00010	COG0592	DNA-directed DNA polymerase activity
KH172YL63_RS00015	COG2501	S4 domain
KH172YL63_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KH172YL63_RS00030	COG0187	DNA topoisomerase II activity
KH172YL63_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KH172YL63_RS00070	COG0386	Belongs to the glutathione peroxidase family
KH172YL63_RS00080	COG0517	IMP dehydrogenase activity
KH172YL63_RS00080	COG0516	GMP reductase activity
KH172YL63_RS00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KH172YL63_RS00115	COG1428	Deoxynucleoside kinase
KH172YL63_RS00120	COG1428	Deoxynucleoside kinase
KH172YL63_RS00125	COG1388	LysM domain
KH172YL63_RS00125	COG3858	chitin binding
KH172YL63_RS00130	COG1335	isochorismatase
KH172YL63_RS00135	COG0590	tRNA wobble adenosine to inosine editing
KH172YL63_RS00145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KH172YL63_RS00150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KH172YL63_RS00155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KH172YL63_RS00215	COG1982	Orn Lys Arg decarboxylase major
KH172YL63_RS00225	COG3870	Protein conserved in bacteria
KH172YL63_RS00230	COG1728	Protein conserved in bacteria
KH172YL63_RS00235	COG0470	DNA polymerase III
KH172YL63_RS00240	COG1774	PSP1 C-terminal conserved region
KH172YL63_RS00245	COG4467	Involved in initiation control of chromosome replication
KH172YL63_RS00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KH172YL63_RS00255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KH172YL63_RS00260	COG2002	toxin-antitoxin pair type II binding
KH172YL63_RS00270	COG0084	hydrolase, TatD family'
KH172YL63_RS00275	COG3584	3D domain protein
KH172YL63_RS00275	COG3583	domain protein
KH172YL63_RS00295	COG4466	Protein conserved in bacteria
KH172YL63_RS00305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KH172YL63_RS00310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KH172YL63_RS00315	COG0251	oxidation-reduction process
KH172YL63_RS00325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KH172YL63_RS00335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KH172YL63_RS00350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KH172YL63_RS00355	COG2002	toxin-antitoxin pair type II binding
KH172YL63_RS00360	COG2244	polysaccharide biosynthetic process
KH172YL63_RS00365	COG3956	TIGRFAM MazG family protein
KH172YL63_RS00370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KH172YL63_RS00385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KH172YL63_RS00390	COG1098	S1 RNA binding domain
KH172YL63_RS00410	COG2208	phosphoserine phosphatase activity
KH172YL63_RS00415	COG2304	oxidoreductase activity
KH172YL63_RS00420	COG0515	serine threonine protein kinase
KH172YL63_RS00425	COG0037	tRNA processing
KH172YL63_RS00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KH172YL63_RS00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KH172YL63_RS00450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KH172YL63_RS00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KH172YL63_RS00460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KH172YL63_RS00465	COG0512	Glutamine amidotransferase of anthranilate synthase
KH172YL63_RS00470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KH172YL63_RS00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KH172YL63_RS00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KH172YL63_RS00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KH172YL63_RS00490	COG1396	sequence-specific DNA binding
KH172YL63_RS00585	COG3880	PFAM UvrB UvrC protein
KH172YL63_RS00590	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KH172YL63_RS00595	COG0542	response to heat
KH172YL63_RS00600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KH172YL63_RS00605	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KH172YL63_RS00610	COG4956	integral membrane protein (PIN domain superfamily)
KH172YL63_RS00620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KH172YL63_RS00625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KH172YL63_RS00630	COG1045	serine acetyltransferase
KH172YL63_RS00635	COG0215	cysteine-tRNA ligase activity
KH172YL63_RS00645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KH172YL63_RS00650	COG3688	RNA-binding protein containing a PIN domain
KH172YL63_RS00660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KH172YL63_RS00665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KH172YL63_RS00670	COG0250	Participates in transcription elongation, termination and antitermination
KH172YL63_RS00675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KH172YL63_RS00680	COG0081	regulation of translation
KH172YL63_RS00690	COG0222	ribosome binding
KH172YL63_RS00695	COG2813	Specifically methylates the guanine in position
KH172YL63_RS00710	COG1358	cellular component organization or biogenesis
KH172YL63_RS00720	COG0049	tRNA binding
KH172YL63_RS00725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KH172YL63_RS00730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KH172YL63_RS00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KH172YL63_RS00745	COG0088	Forms part of the polypeptide exit tunnel
KH172YL63_RS00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KH172YL63_RS00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KH172YL63_RS00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KH172YL63_RS00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KH172YL63_RS00780	COG0255	Belongs to the universal ribosomal protein uL29 family
KH172YL63_RS00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KH172YL63_RS00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KH172YL63_RS00805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KH172YL63_RS00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KH172YL63_RS00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KH172YL63_RS00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KH172YL63_RS00830	COG1841	ribosomal large subunit assembly
KH172YL63_RS00840	COG0201	protein transport
KH172YL63_RS00845	COG0563	adenylate kinase activity
KH172YL63_RS00850	COG0024	Methionine aminopeptidase
KH172YL63_RS00855	COG2163	COG2163 Ribosomal protein L14E L6E L27E
KH172YL63_RS00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KH172YL63_RS00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KH172YL63_RS00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KH172YL63_RS00880	COG0202	RNA polymerase activity
KH172YL63_RS00885	COG0203	ribosomal protein L17
KH172YL63_RS00890	COG1122	ATPase activity
KH172YL63_RS00895	COG1122	ATPase activity
KH172YL63_RS00900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KH172YL63_RS00905	COG0101	tRNA pseudouridine synthase activity
KH172YL63_RS00910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KH172YL63_RS00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KH172YL63_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS00930	COG0489	protein tyrosine kinase activity
KH172YL63_RS00940	COG2194	sulfuric ester hydrolase activity
KH172YL63_RS00945	COG0726	polysaccharide deacetylase
KH172YL63_RS01025	COG1595	DNA-templated transcription, initiation
KH172YL63_RS01030	COG5662	AntiSigma factor
KH172YL63_RS01035	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KH172YL63_RS01040	COG4856	YbbR-like protein
KH172YL63_RS01045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KH172YL63_RS01050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KH172YL63_RS01060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KH172YL63_RS01075	COG0523	cobalamin synthesis protein
KH172YL63_RS01080	COG0701	Predicted permease
KH172YL63_RS01095	COG3403	YqcI/YcgG family
KH172YL63_RS01105	COG2340	Cysteine-rich secretory protein family
KH172YL63_RS01110	COG2094	Belongs to the DNA glycosylase MPG family
KH172YL63_RS01120	COG0601	transmembrane transport
KH172YL63_RS01125	COG2861	carbohydrate metabolic process
KH172YL63_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS01140	COG2814	Major facilitator Superfamily
KH172YL63_RS01160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KH172YL63_RS01165	COG1115	amino acid carrier protein
KH172YL63_RS01175	COG0517	IMP dehydrogenase activity
KH172YL63_RS01180	COG2340	Cysteine-rich secretory protein family
KH172YL63_RS01190	COG1597	lipid kinase activity
KH172YL63_RS01195	COG1238	metal cluster binding
KH172YL63_RS01210	COG0772	Belongs to the SEDS family
KH172YL63_RS01220	COG1489	DNA binding
KH172YL63_RS01230	COG4134	Bacterial extracellular solute-binding protein
KH172YL63_RS01250	COG0398	Pfam SNARE associated Golgi protein
KH172YL63_RS01260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KH172YL63_RS01280	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KH172YL63_RS01285	COG1181	Belongs to the D-alanine--D-alanine ligase family
KH172YL63_RS01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KH172YL63_RS01300	COG0513	Belongs to the DEAD box helicase family
KH172YL63_RS01310	COG4294	response to UV
KH172YL63_RS01315	COG3402	PFAM membrane-flanked domain
KH172YL63_RS01320	COG3428	Bacterial PH domain
KH172YL63_RS01325	COG0705	Rhomboid family
KH172YL63_RS01330	COG0736	holo-[acyl-carrier-protein] synthase activity
KH172YL63_RS01335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KH172YL63_RS01345	COG0864	Transcriptional regulator
KH172YL63_RS01350	COG2337	Toxic component of a toxin-antitoxin (TA) module
KH172YL63_RS01355	COG1366	Belongs to the anti-sigma-factor antagonist family
KH172YL63_RS01360	COG1366	Belongs to the anti-sigma-factor antagonist family
KH172YL63_RS01365	COG2172	sigma factor antagonist activity
KH172YL63_RS01370	COG2208	phosphoserine phosphatase activity
KH172YL63_RS01375	COG1366	Belongs to the anti-sigma-factor antagonist family
KH172YL63_RS01380	COG2172	sigma factor antagonist activity
KH172YL63_RS01385	COG1191	sigma factor activity
KH172YL63_RS01390	COG2208	phosphoserine phosphatase activity
KH172YL63_RS01395	COG2183	response to ionizing radiation
KH172YL63_RS01490	COG0802	atpase or kinase
KH172YL63_RS01495	COG1214	PFAM Peptidase M22, glycoprotease
KH172YL63_RS01500	COG0456	acetyltransferase
KH172YL63_RS01510	COG0488	(ABC) transporter
KH172YL63_RS01515	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KH172YL63_RS01520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KH172YL63_RS01525	COG0805	protein transport
KH172YL63_RS01535	COG1266	CAAX protease self-immunity
KH172YL63_RS01540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KH172YL63_RS01545	COG0459	protein refolding
KH172YL63_RS01550	COG0582	viral genome integration into host DNA
KH172YL63_RS01575	COG0582	viral genome integration into host DNA
KH172YL63_RS01605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KH172YL63_RS01630	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
KH172YL63_RS01670	COG3973	AAA domain
KH172YL63_RS01685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KH172YL63_RS01720	COG2304	oxidoreductase activity
KH172YL63_RS01755	COG2304	oxidoreductase activity
KH172YL63_RS01825	COG2304	oxidoreductase activity
KH172YL63_RS01845	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KH172YL63_RS01860	COG0714	Associated with various cellular activities
KH172YL63_RS01865	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KH172YL63_RS01870	COG1305	Transglutaminase-like
KH172YL63_RS01875	COG0519	Catalyzes the synthesis of GMP from XMP
KH172YL63_RS01875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KH172YL63_RS01880	COG2252	PERMEase
KH172YL63_RS01885	COG3711	transcriptional antiterminator
KH172YL63_RS01890	COG2190	(PTS) system
KH172YL63_RS01890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KH172YL63_RS01890	COG1263	PTS System
KH172YL63_RS01910	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KH172YL63_RS01920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KH172YL63_RS01925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KH172YL63_RS01930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KH172YL63_RS01940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KH172YL63_RS01945	COG0047	phosphoribosylformylglycinamidine synthase activity
KH172YL63_RS01955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KH172YL63_RS01965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KH172YL63_RS01975	COG0151	Belongs to the GarS family
KH172YL63_RS01990	COG1470	cell adhesion involved in biofilm formation
KH172YL63_RS01995	COG4496	protein, YerC YecD
KH172YL63_RS02000	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KH172YL63_RS02005	COG0210	DNA helicase
KH172YL63_RS02010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KH172YL63_RS02015	COG4851	CamS sex pheromone cAM373 precursor
KH172YL63_RS02020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KH172YL63_RS02025	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KH172YL63_RS02030	COG2224	Isocitrate lyase
KH172YL63_RS02035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KH172YL63_RS02040	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KH172YL63_RS02055	COG0505	Belongs to the CarA family
KH172YL63_RS02060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KH172YL63_RS02065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KH172YL63_RS02070	COG5506	Protein of unknown function (DUF1694)
KH172YL63_RS02080	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KH172YL63_RS02125	COG2226	methyltransferase
KH172YL63_RS02140	COG1597	lipid kinase activity
KH172YL63_RS02165	COG0166	Belongs to the GPI family
KH172YL63_RS02170	COG4895	conserved protein (DUF2196)
KH172YL63_RS02175	COG1914	H( )-stimulated, divalent metal cation uptake system
KH172YL63_RS02180	COG1984	allophanate hydrolase subunit 2
KH172YL63_RS02185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KH172YL63_RS02190	COG2814	Major facilitator Superfamily
KH172YL63_RS02200	COG1366	Belongs to the anti-sigma-factor antagonist family
KH172YL63_RS02215	COG1126	abc transporter atp-binding protein
KH172YL63_RS02220	COG1595	DNA-templated transcription, initiation
KH172YL63_RS02230	COG1131	(ABC) transporter
KH172YL63_RS02235	COG1725	Transcriptional regulator
KH172YL63_RS02240	COG1131	(ABC) transporter
KH172YL63_RS02260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KH172YL63_RS02265	COG1595	DNA-templated transcription, initiation
KH172YL63_RS02280	COG3859	Proton-coupled thiamine transporter YuaJ
KH172YL63_RS02285	COG2966	Psort location CytoplasmicMembrane, score
KH172YL63_RS02290	COG3610	response to peptide
KH172YL63_RS02300	COG1132	(ABC) transporter
KH172YL63_RS02305	COG1132	(ABC) transporter
KH172YL63_RS02310	COG3871	stress protein (general stress protein 26)
KH172YL63_RS02320	COG2323	membrane
KH172YL63_RS02330	COG1115	amino acid carrier protein
KH172YL63_RS02340	COG1960	acyl-CoA dehydrogenase activity
KH172YL63_RS02355	COG0584	glycerophosphoryl diester phosphodiesterase
KH172YL63_RS02360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KH172YL63_RS02370	COG2364	Membrane
KH172YL63_RS02375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KH172YL63_RS02375	COG1199	ATP-dependent helicase activity
KH172YL63_RS02380	COG2193	ferroxidase activity
KH172YL63_RS02395	COG1404	Belongs to the peptidase S8 family
KH172YL63_RS02400	COG2032	superoxide dismutase activity
KH172YL63_RS02405	COG0733	neurotransmitter:sodium symporter activity
KH172YL63_RS02410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KH172YL63_RS02415	COG0488	(ABC) transporter
KH172YL63_RS02425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KH172YL63_RS02430	COG1846	Transcriptional regulator
KH172YL63_RS02435	COG0477	Major facilitator Superfamily
KH172YL63_RS02440	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KH172YL63_RS02445	COG3396	Phenylacetate-CoA oxygenase
KH172YL63_RS02460	COG2151	metal-sulfur cluster biosynthetic enzyme
KH172YL63_RS02475	COG1024	Enoyl-CoA hydratase
KH172YL63_RS02480	COG1012	belongs to the aldehyde dehydrogenase family
KH172YL63_RS02485	COG1250	3-hydroxyacyl-CoA dehydrogenase
KH172YL63_RS02490	COG0183	Belongs to the thiolase family
KH172YL63_RS02500	COG3327	negative regulation of DNA-templated transcription, initiation
KH172YL63_RS02515	COG4120	Belongs to the binding-protein-dependent transport system permease family
KH172YL63_RS02540	COG0022	dehydrogenase e1 component
KH172YL63_RS02555	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KH172YL63_RS02560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KH172YL63_RS02565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KH172YL63_RS02570	COG0179	Fumarylacetoacetate (FAA) hydrolase
KH172YL63_RS02580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KH172YL63_RS02585	COG0129	dihydroxy-acid dehydratase activity
KH172YL63_RS02590	COG0028	Belongs to the TPP enzyme family
KH172YL63_RS02595	COG0440	acetolactate synthase activity
KH172YL63_RS02600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KH172YL63_RS02605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KH172YL63_RS02615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KH172YL63_RS02620	COG0066	3-isopropylmalate dehydratase activity
KH172YL63_RS02625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KH172YL63_RS02630	COG0460	homoserine dehydrogenase
KH172YL63_RS02635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KH172YL63_RS02640	COG0083	homoserine kinase activity
KH172YL63_RS02655	COG3852	Histidine kinase
KH172YL63_RS02670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KH172YL63_RS02680	COG0210	DNA helicase
KH172YL63_RS02695	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KH172YL63_RS02720	COG1737	Transcriptional regulator
KH172YL63_RS02725	COG2610	gluconate transmembrane transporter activity
KH172YL63_RS02730	COG1070	Carbohydrate kinase
KH172YL63_RS02765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KH172YL63_RS02775	COG0702	epimerase
KH172YL63_RS02785	COG1309	transcriptional regulator
KH172YL63_RS02790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KH172YL63_RS02795	COG2244	polysaccharide biosynthetic process
KH172YL63_RS02830	COG4585	Histidine kinase
KH172YL63_RS02835	COG2197	response regulator
KH172YL63_RS02855	COG0714	Associated with various cellular activities
KH172YL63_RS02895	COG1714	RDD family
KH172YL63_RS02905	COG1012	belongs to the aldehyde dehydrogenase family
KH172YL63_RS02910	COG2130	NADP-dependent
KH172YL63_RS02920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KH172YL63_RS02935	COG0288	reversible hydration of carbon dioxide
KH172YL63_RS02950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KH172YL63_RS02990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KH172YL63_RS03000	COG0488	(ABC) transporter
KH172YL63_RS03015	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KH172YL63_RS03045	COG1077	Cell shape determining protein MreB Mrl
KH172YL63_RS03050	COG0840	transmembrane signaling receptor activity
KH172YL63_RS03060	COG1607	acyl-coa hydrolase
KH172YL63_RS03065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KH172YL63_RS03095	COG2309	aminopeptidase activity
KH172YL63_RS03105	COG1959	2 iron, 2 sulfur cluster binding
KH172YL63_RS03135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KH172YL63_RS03140	COG1360	Flagellar Motor Protein
KH172YL63_RS03145	COG1115	amino acid carrier protein
KH172YL63_RS03150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KH172YL63_RS03155	COG2313	pseudouridylate synthase activity
KH172YL63_RS03160	COG5002	protein histidine kinase activity
KH172YL63_RS03165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KH172YL63_RS03170	COG0275	rRNA processing
KH172YL63_RS03175	COG3486	L-lysine 6-monooxygenase (NADPH) activity
KH172YL63_RS03180	COG0693	protein deglycase activity
KH172YL63_RS03185	COG4840	Belongs to the UPF0435 family
KH172YL63_RS03190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KH172YL63_RS03195	COG4980	gas vesicle protein
KH172YL63_RS03200	COG1295	ribonuclease BN
KH172YL63_RS03205	COG3275	phosphorelay sensor kinase activity
KH172YL63_RS03210	COG3279	Response regulator of the LytR AlgR family
KH172YL63_RS03215	COG1966	Carbon starvation protein
KH172YL63_RS03225	COG1595	DNA-templated transcription, initiation
KH172YL63_RS03250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KH172YL63_RS03270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KH172YL63_RS03275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KH172YL63_RS03280	COG2223	nitrite transmembrane transporter activity
KH172YL63_RS03290	COG3383	formate dehydrogenase (NAD+) activity
KH172YL63_RS03295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KH172YL63_RS03300	COG0303	'Molybdopterin
KH172YL63_RS03305	COG0314	molybdopterin synthase activity
KH172YL63_RS03310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KH172YL63_RS03315	COG0521	Mo-molybdopterin cofactor biosynthetic process
KH172YL63_RS03320	COG0725	ABC transporter, periplasmic molybdate-binding protein
KH172YL63_RS03325	COG4149	molybdate abc transporter
KH172YL63_RS03340	COG0746	molybdenum cofactor guanylyltransferase activity
KH172YL63_RS03350	COG0028	Belongs to the TPP enzyme family
KH172YL63_RS03365	COG2217	Heavy metal translocating P-type atpase
KH172YL63_RS03370	COG0477	Major facilitator Superfamily
KH172YL63_RS03380	COG0387	Pfam Sodium calcium exchanger
KH172YL63_RS03400	COG0535	radical SAM domain protein
KH172YL63_RS03430	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KH172YL63_RS03435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KH172YL63_RS03440	COG3507	Belongs to the glycosyl hydrolase 43 family
KH172YL63_RS03445	COG1940	carbohydrate kinase activity
KH172YL63_RS03450	COG1653	transport
KH172YL63_RS03455	COG1175	transmembrane transport
KH172YL63_RS03460	COG0395	ABC-type sugar transport system, permease component
KH172YL63_RS03465	COG5578	integral membrane protein
KH172YL63_RS03475	COG1070	Carbohydrate kinase
KH172YL63_RS03480	COG0667	Aldo Keto reductase
KH172YL63_RS03485	COG2017	converts alpha-aldose to the beta-anomer
KH172YL63_RS03490	COG0477	Major facilitator Superfamily
KH172YL63_RS03490	COG2814	Major facilitator Superfamily
KH172YL63_RS03495	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
KH172YL63_RS03510	COG1396	sequence-specific DNA binding
KH172YL63_RS03580	COG2211	Major facilitator Superfamily
KH172YL63_RS03585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KH172YL63_RS03590	COG1335	isochorismatase
KH172YL63_RS03630	COG1595	DNA-templated transcription, initiation
KH172YL63_RS03640	COG0772	Belongs to the SEDS family
KH172YL63_RS03670	COG0346	lactoylglutathione lyase activity
KH172YL63_RS03680	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS03710	COG1129	ABC transporter
KH172YL63_RS03710	COG0842	Transport permease protein
KH172YL63_RS03730	COG0840	transmembrane signaling receptor activity
KH172YL63_RS03730	COG5278	phosphoserine phosphatase activity
KH172YL63_RS03755	COG5646	InterPro IPR014922
KH172YL63_RS03765	COG3414	Phosphotransferase system galactitol-specific IIB component
KH172YL63_RS03770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KH172YL63_RS03770	COG3711	transcriptional antiterminator
KH172YL63_RS03775	COG0488	(ABC) transporter
KH172YL63_RS03790	COG0583	DNA-binding transcription factor activity
KH172YL63_RS03795	COG0730	response to heat
KH172YL63_RS03810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KH172YL63_RS03825	COG1366	Belongs to the anti-sigma-factor antagonist family
KH172YL63_RS03840	COG1366	Belongs to the anti-sigma-factor antagonist family
KH172YL63_RS03855	COG3711	transcriptional antiterminator
KH172YL63_RS03860	COG0246	Mannitol dehydrogenase
KH172YL63_RS03870	COG0019	diaminopimelate decarboxylase activity
KH172YL63_RS03895	COG0583	DNA-binding transcription factor activity
KH172YL63_RS03900	COG1511	domain protein
KH172YL63_RS03910	COG0501	Belongs to the peptidase M48B family
KH172YL63_RS03915	COG5632	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS03920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KH172YL63_RS03940	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KH172YL63_RS03950	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KH172YL63_RS03955	COG0351	phosphomethylpyrimidine kinase
KH172YL63_RS03960	COG0352	thiamine-phosphate diphosphorylase activity
KH172YL63_RS03975	COG1136	(ABC) transporter
KH172YL63_RS03990	COG3459	Glycosyltransferase 36 associated
KH172YL63_RS04000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KH172YL63_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS04015	COG3239	Fatty acid desaturase
KH172YL63_RS04020	COG2197	response regulator
KH172YL63_RS04025	COG1187	pseudouridine synthase activity
KH172YL63_RS04030	COG0789	Transcriptional regulator
KH172YL63_RS04045	COG1278	Cold shock
KH172YL63_RS04060	COG0840	transmembrane signaling receptor activity
KH172YL63_RS04060	COG3290	protein histidine kinase activity
KH172YL63_RS04065	COG1609	Transcriptional regulator
KH172YL63_RS04085	COG0395	ABC-type sugar transport system, permease component
KH172YL63_RS04095	COG0395	ABC-type sugar transport system, permease component
KH172YL63_RS04100	COG1175	transmembrane transport
KH172YL63_RS04115	COG3459	Glycosyltransferase 36 associated
KH172YL63_RS04125	COG1595	DNA-templated transcription, initiation
KH172YL63_RS04145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KH172YL63_RS04150	COG1115	amino acid carrier protein
KH172YL63_RS04160	COG2188	Transcriptional regulator
KH172YL63_RS04175	COG5001	Diguanylate cyclase
KH172YL63_RS04175	COG3300	MHYT domain
KH172YL63_RS04180	COG2824	Alkylphosphonate utilization operon protein PhnA
KH172YL63_RS04200	COG0640	Transcriptional regulator
KH172YL63_RS04225	COG1012	belongs to the aldehyde dehydrogenase family
KH172YL63_RS04255	COG1395	domain, Protein
KH172YL63_RS04265	COG1231	oxidoreductase activity
KH172YL63_RS04275	COG3708	Transcriptional regulator
KH172YL63_RS04275	COG2207	Transcriptional regulator
KH172YL63_RS04280	COG2132	Multicopper oxidase
KH172YL63_RS04300	COG5002	protein histidine kinase activity
KH172YL63_RS04305	COG0778	Nitroreductase
KH172YL63_RS04310	COG1918	ferrous iron import across plasma membrane
KH172YL63_RS04310	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KH172YL63_RS04315	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KH172YL63_RS04320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KH172YL63_RS04330	COG1737	Transcriptional regulator
KH172YL63_RS04345	COG0067	glutamate synthase
KH172YL63_RS04345	COG0069	glutamate synthase activity
KH172YL63_RS04345	COG0070	glutamate synthase
KH172YL63_RS04350	COG0493	'glutamate synthase
KH172YL63_RS04355	COG1263	PTS System
KH172YL63_RS04355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KH172YL63_RS04365	COG1657	PFAM Prenyltransferase squalene oxidase
KH172YL63_RS04380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KH172YL63_RS04400	COG1595	DNA-templated transcription, initiation
KH172YL63_RS04430	COG1607	acyl-coa hydrolase
KH172YL63_RS04445	COG2207	Transcriptional regulator
KH172YL63_RS04455	COG2268	Band 7 protein
KH172YL63_RS04460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KH172YL63_RS04465	COG0737	Belongs to the 5'-nucleotidase family
KH172YL63_RS04470	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
KH172YL63_RS04475	COG0277	FAD linked oxidase domain protein
KH172YL63_RS04480	COG0385	Bile acid
KH172YL63_RS04490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KH172YL63_RS04495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KH172YL63_RS04500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KH172YL63_RS04505	COG1120	ATPase activity
KH172YL63_RS04510	COG0492	ferredoxin-NADP+ reductase activity
KH172YL63_RS04520	COG0861	Integral membrane protein TerC family
KH172YL63_RS04540	COG0697	spore germination
KH172YL63_RS04555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KH172YL63_RS04560	COG2270	Major facilitator Superfamily
KH172YL63_RS04570	COG1664	Polymer-forming cytoskeletal
KH172YL63_RS04575	COG0789	Transcriptional regulator
KH172YL63_RS04580	COG2188	Transcriptional regulator
KH172YL63_RS04585	COG1131	(ABC) transporter
KH172YL63_RS04610	COG0542	response to heat
KH172YL63_RS04620	COG0561	phosphatase activity
KH172YL63_RS04625	COG1132	(ABC) transporter
KH172YL63_RS04635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KH172YL63_RS04665	COG1090	epimerase
KH172YL63_RS04685	COG0300	oxidoreductase activity
KH172YL63_RS04710	COG1988	membrane-bound metal-dependent
KH172YL63_RS04720	COG1194	a g-specific adenine glycosylase
KH172YL63_RS04730	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS04745	COG3557	Belongs to the UPF0374 family
KH172YL63_RS04750	COG1132	(ABC) transporter
KH172YL63_RS04755	COG0444	Belongs to the ABC transporter superfamily
KH172YL63_RS04760	COG4608	Belongs to the ABC transporter superfamily
KH172YL63_RS04765	COG0747	negative chemotaxis
KH172YL63_RS04780	COG4129	membrane
KH172YL63_RS04785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KH172YL63_RS04790	COG4555	ABC transporter
KH172YL63_RS04810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KH172YL63_RS04815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KH172YL63_RS04820	COG2096	Adenosyltransferase
KH172YL63_RS04825	COG0735	belongs to the Fur family
KH172YL63_RS04950	COG2972	Histidine kinase
KH172YL63_RS04955	COG4753	response regulator
KH172YL63_RS04955	COG2207	Transcriptional regulator
KH172YL63_RS04965	COG0673	inositol 2-dehydrogenase activity
KH172YL63_RS04970	COG0673	inositol 2-dehydrogenase activity
KH172YL63_RS04975	COG1082	Xylose isomerase domain protein TIM barrel
KH172YL63_RS04985	COG3382	B3 4 domain protein
KH172YL63_RS04990	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KH172YL63_RS05000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KH172YL63_RS05005	COG0778	Nitroreductase
KH172YL63_RS05010	COG2766	serine protein kinase
KH172YL63_RS05025	COG2718	Belongs to the UPF0229 family
KH172YL63_RS05035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KH172YL63_RS05045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KH172YL63_RS05050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KH172YL63_RS05065	COG0039	L-malate dehydrogenase activity
KH172YL63_RS05080	COG0406	alpha-ribazole phosphatase activity
KH172YL63_RS05085	COG2252	PERMEase
KH172YL63_RS05090	COG4187	Peptidase family M20/M25/M40
KH172YL63_RS05095	COG0778	Nitroreductase
KH172YL63_RS05100	COG1733	regulation of RNA biosynthetic process
KH172YL63_RS05110	COG1609	Transcriptional regulator
KH172YL63_RS05115	COG1970	mechanosensitive ion channel activity
KH172YL63_RS05125	COG2205	protein histidine kinase activity
KH172YL63_RS05130	COG3973	AAA domain
KH172YL63_RS05140	COG0656	L-ascorbic acid biosynthetic process
KH172YL63_RS05145	COG2259	Doxx family
KH172YL63_RS05150	COG1741	Belongs to the pirin family
KH172YL63_RS05155	COG0655	NAD(P)H dehydrogenase (quinone) activity
KH172YL63_RS05160	COG0564	pseudouridine synthase activity
KH172YL63_RS05175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KH172YL63_RS05180	COG0366	Alpha amylase catalytic
KH172YL63_RS05185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KH172YL63_RS05185	COG3153	acetyltransferase
KH172YL63_RS05190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KH172YL63_RS05195	COG2203	Gaf domain
KH172YL63_RS05195	COG4585	Histidine kinase
KH172YL63_RS05200	COG2197	response regulator
KH172YL63_RS05205	COG0431	NADPH-dependent FMN reductase
KH172YL63_RS05220	COG2211	Major facilitator Superfamily
KH172YL63_RS05225	COG2719	SpoVR family
KH172YL63_RS05235	COG2364	Membrane
KH172YL63_RS05240	COG0471	metal ion transport
KH172YL63_RS05245	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS05250	COG2610	gluconate transmembrane transporter activity
KH172YL63_RS05255	COG1253	flavin adenine dinucleotide binding
KH172YL63_RS05285	COG4989	oxidoreductase activity
KH172YL63_RS05295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KH172YL63_RS05305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KH172YL63_RS05315	COG0084	hydrolase, TatD family'
KH172YL63_RS05325	COG1533	DNA photolyase activity
KH172YL63_RS05335	COG1301	dicarboxylic acid transport
KH172YL63_RS05340	COG0415	Belongs to the DNA photolyase family
KH172YL63_RS05355	COG2814	Major facilitator Superfamily
KH172YL63_RS05360	COG1595	DNA-templated transcription, initiation
KH172YL63_RS05375	COG0393	Putative heavy-metal-binding
KH172YL63_RS05380	COG1132	(ABC) transporter
KH172YL63_RS05385	COG1132	(ABC) transporter
KH172YL63_RS05410	COG0702	epimerase
KH172YL63_RS05415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KH172YL63_RS05420	COG0765	amino acid transport
KH172YL63_RS05425	COG1126	abc transporter atp-binding protein
KH172YL63_RS05430	COG1268	BioY protein
KH172YL63_RS05435	COG0318	PFAM AMP-dependent synthetase and ligase
KH172YL63_RS05440	COG0183	Belongs to the thiolase family
KH172YL63_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS05450	COG0114	fumarate hydratase activity
KH172YL63_RS05465	COG3842	ATPase activity
KH172YL63_RS05470	COG2508	Transcriptional regulator
KH172YL63_RS05475	COG1937	Protein conserved in bacteria
KH172YL63_RS05500	COG0189	ligase activity
KH172YL63_RS05505	COG0189	ligase activity
KH172YL63_RS05515	COG4399	Belongs to the UPF0754 family
KH172YL63_RS05525	COG0561	phosphatase activity
KH172YL63_RS05530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KH172YL63_RS05535	COG1024	Enoyl-CoA hydratase
KH172YL63_RS05545	COG4152	abc transporter atp-binding protein
KH172YL63_RS05550	COG1668	transmembrane transport
KH172YL63_RS05555	COG0420	3'-5' exonuclease activity
KH172YL63_RS05560	COG4717	serine-type aminopeptidase activity
KH172YL63_RS05565	COG2814	Major facilitator Superfamily
KH172YL63_RS05570	COG3481	metal-dependent phosphohydrolase, HD sub domain
KH172YL63_RS05580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KH172YL63_RS05610	COG1846	Transcriptional regulator
KH172YL63_RS05630	COG0537	adenosine 5'-monophosphoramidase activity
KH172YL63_RS05635	COG1131	(ABC) transporter
KH172YL63_RS05640	COG4473	ABC transporter
KH172YL63_RS05655	COG1473	amidohydrolase
KH172YL63_RS05660	COG0671	phosphoesterase, PA-phosphatase related
KH172YL63_RS05665	COG3069	C4-dicarboxylate transmembrane transporter activity
KH172YL63_RS05675	COG4585	Histidine kinase
KH172YL63_RS05680	COG2197	response regulator
KH172YL63_RS05685	COG1335	isochorismatase
KH172YL63_RS05690	COG2329	Antibiotic biosynthesis monooxygenase
KH172YL63_RS05695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KH172YL63_RS05710	COG0456	acetyltransferase
KH172YL63_RS05720	COG1511	domain protein
KH172YL63_RS05735	COG1234	tRNA 3'-trailer cleavage
KH172YL63_RS05740	COG0095	Lipoate-protein ligase
KH172YL63_RS05745	COG0318	PFAM AMP-dependent synthetase and ligase
KH172YL63_RS05750	COG1024	Enoyl-CoA hydratase
KH172YL63_RS05770	COG2391	methyltransferase activity
KH172YL63_RS05775	COG5337	Spore coat protein CotH
KH172YL63_RS05780	COG1396	sequence-specific DNA binding
KH172YL63_RS05785	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KH172YL63_RS05795	COG0501	Belongs to the peptidase M48B family
KH172YL63_RS05820	COG4946	Tricorn protease homolog
KH172YL63_RS05820	COG1506	peptidase
KH172YL63_RS05820	COG0823	Involved in the tonB-independent uptake of proteins
KH172YL63_RS05825	COG0398	Pfam SNARE associated Golgi protein
KH172YL63_RS05835	COG3437	response regulator, receiver
KH172YL63_RS05835	COG2770	Histidine kinase
KH172YL63_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS05845	COG0183	Belongs to the thiolase family
KH172YL63_RS05850	COG2356	endonuclease I
KH172YL63_RS05865	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KH172YL63_RS05870	COG1074	ATP-dependent DNA helicase activity
KH172YL63_RS05875	COG1403	HNH endonuclease
KH172YL63_RS05910	COG2311	Membrane
KH172YL63_RS05915	COG0179	Fumarylacetoacetate (FAA) hydrolase
KH172YL63_RS05935	COG0367	asparagine synthase
KH172YL63_RS05955	COG0004	ammonium transporteR
KH172YL63_RS05960	COG0347	Belongs to the P(II) protein family
KH172YL63_RS05965	COG0534	Mate efflux family protein
KH172YL63_RS05975	COG2182	Extracellular solute-binding protein
KH172YL63_RS05980	COG1175	transmembrane transport
KH172YL63_RS05985	COG3833	ABC-type maltose transport systems, permease component
KH172YL63_RS05990	COG0366	Alpha amylase catalytic
KH172YL63_RS05990	COG1874	Beta-galactosidase
KH172YL63_RS05995	COG1609	Transcriptional regulator
KH172YL63_RS06000	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS06005	COG0446	pyridine nucleotide-disulphide oxidoreductase
KH172YL63_RS06010	COG1666	GTP binding
KH172YL63_RS06020	COG1307	EDD domain protein, DegV family
KH172YL63_RS06025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KH172YL63_RS06045	COG0561	phosphatase activity
KH172YL63_RS06050	COG1073	alpha beta
KH172YL63_RS06055	COG2151	metal-sulfur cluster biosynthetic enzyme
KH172YL63_RS06060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KH172YL63_RS06085	COG2267	carboxylic ester hydrolase activity
KH172YL63_RS06095	COG1744	ABC transporter substrate-binding protein PnrA-like
KH172YL63_RS06105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KH172YL63_RS06110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KH172YL63_RS06115	COG5504	Zn-dependent protease
KH172YL63_RS06125	COG0180	Tryptophanyl-tRNA synthetase
KH172YL63_RS06135	COG4166	transmembrane transport
KH172YL63_RS06140	COG0601	transmembrane transport
KH172YL63_RS06145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KH172YL63_RS06150	COG0444	Belongs to the ABC transporter superfamily
KH172YL63_RS06155	COG4608	Belongs to the ABC transporter superfamily
KH172YL63_RS06165	COG0456	acetyltransferase
KH172YL63_RS06170	COG1393	Belongs to the ArsC family
KH172YL63_RS06175	COG4862	establishment of competence for transformation
KH172YL63_RS06190	COG1164	Oligoendopeptidase f
KH172YL63_RS06205	COG2346	COG2346, Truncated hemoglobins
KH172YL63_RS06210	COG0741	lytic transglycosylase activity
KH172YL63_RS06215	COG4116	CYTH
KH172YL63_RS06225	COG2357	RelA SpoT domain protein
KH172YL63_RS06235	COG0564	pseudouridine synthase activity
KH172YL63_RS06240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KH172YL63_RS06245	COG2239	Acts as a magnesium transporter
KH172YL63_RS06250	COG0569	domain protein
KH172YL63_RS06250	COG0475	glutathione-regulated potassium exporter activity
KH172YL63_RS06260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KH172YL63_RS06290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KH172YL63_RS06300	COG2323	membrane
KH172YL63_RS06320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KH172YL63_RS06325	COG2323	membrane
KH172YL63_RS06330	COG2153	protein acetylation
KH172YL63_RS06335	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KH172YL63_RS06340	COG2382	esterase
KH172YL63_RS06345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KH172YL63_RS06350	COG2358	TRAP transporter, solute receptor (TAXI family
KH172YL63_RS06390	COG1737	Transcriptional regulator
KH172YL63_RS06395	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KH172YL63_RS06405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KH172YL63_RS06415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KH172YL63_RS06420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KH172YL63_RS06430	COG1764	response to oxidative stress
KH172YL63_RS06435	COG1278	Cold shock
KH172YL63_RS06450	COG1295	ribonuclease BN
KH172YL63_RS06455	COG3104	oligopeptide transport
KH172YL63_RS06460	COG1363	Peptidase, m42
KH172YL63_RS06465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KH172YL63_RS06470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KH172YL63_RS06480	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KH172YL63_RS06485	COG3300	MHYT domain
KH172YL63_RS06485	COG5001	Diguanylate cyclase
KH172YL63_RS06500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KH172YL63_RS06515	COG0861	Integral membrane protein TerC family
KH172YL63_RS06525	COG1191	sigma factor activity
KH172YL63_RS06540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KH172YL63_RS06560	COG3594	Acyltransferase
KH172YL63_RS06565	COG5002	protein histidine kinase activity
KH172YL63_RS06570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KH172YL63_RS06580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KH172YL63_RS06585	COG0436	Aminotransferase
KH172YL63_RS06595	COG1846	Transcriptional regulator
KH172YL63_RS06605	COG3949	Membrane
KH172YL63_RS06615	COG4873	Protein conserved in bacteria
KH172YL63_RS06625	COG3773	Cell wall hydrolase
KH172YL63_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS06640	COG0714	Associated with various cellular activities
KH172YL63_RS06655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KH172YL63_RS06660	COG0390	transport system, permease component
KH172YL63_RS06670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KH172YL63_RS06675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KH172YL63_RS06680	COG0456	acetyltransferase
KH172YL63_RS06690	COG0436	Aminotransferase
KH172YL63_RS06695	COG0598	Magnesium transport protein CorA
KH172YL63_RS06705	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KH172YL63_RS06710	COG0720	synthase
KH172YL63_RS06715	COG0602	queuosine metabolic process
KH172YL63_RS06725	COG0835	chemotaxis
KH172YL63_RS06725	COG0784	Response regulator, receiver
KH172YL63_RS06740	COG3300	MHYT domain
KH172YL63_RS06740	COG5001	Diguanylate cyclase
KH172YL63_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS06755	COG2200	EAL domain
KH172YL63_RS06775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS06780	COG4703	Protein of unknown function (DUF1797)
KH172YL63_RS06785	COG0517	IMP dehydrogenase activity
KH172YL63_RS06790	COG0477	Major facilitator Superfamily
KH172YL63_RS06800	COG0583	DNA-binding transcription factor activity
KH172YL63_RS06810	COG1473	amidohydrolase
KH172YL63_RS06815	COG0668	transmembrane transport
KH172YL63_RS06820	COG1132	(ABC) transporter
KH172YL63_RS06825	COG1132	(ABC) transporter
KH172YL63_RS06830	COG1271	oxidase subunit
KH172YL63_RS06835	COG1294	oxidase, subunit
KH172YL63_RS06840	COG0569	domain protein
KH172YL63_RS06845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KH172YL63_RS06855	COG0561	phosphatase activity
KH172YL63_RS06875	COG0022	dehydrogenase e1 component
KH172YL63_RS06900	COG0726	polysaccharide deacetylase
KH172YL63_RS06910	COG1982	Orn Lys Arg decarboxylase major
KH172YL63_RS06920	COG4476	Belongs to the UPF0223 family
KH172YL63_RS06935	COG0483	inositol monophosphate 1-phosphatase activity
KH172YL63_RS06960	COG4896	Protein conserved in bacteria
KH172YL63_RS06975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KH172YL63_RS06980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KH172YL63_RS06985	COG2066	Belongs to the glutaminase family
KH172YL63_RS06990	COG4838	Belongs to the UPF0358 family
KH172YL63_RS06995	COG0772	Belongs to the SEDS family
KH172YL63_RS07000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KH172YL63_RS07025	COG1845	cytochrome c oxidase, subunit III
KH172YL63_RS07035	COG3336	cytochrome c oxidase
KH172YL63_RS07055	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KH172YL63_RS07060	COG2340	Cysteine-rich secretory protein family
KH172YL63_RS07085	COG3679	Belongs to the UPF0342 family
KH172YL63_RS07110	COG0742	ribosomal rna small subunit methyltransferase
KH172YL63_RS07115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KH172YL63_RS07120	COG3314	Sporulation integral membrane protein YlbJ
KH172YL63_RS07125	COG1752	Esterase of the alpha-beta hydrolase superfamily
KH172YL63_RS07130	COG3480	Lon protease (S16) C-terminal proteolytic domain
KH172YL63_RS07135	COG1323	Belongs to the UPF0348 family
KH172YL63_RS07140	COG1399	metal-binding, possibly nucleic acid-binding protein
KH172YL63_RS07145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KH172YL63_RS07150	COG1024	Enoyl-CoA hydratase
KH172YL63_RS07160	COG0454	-acetyltransferase
KH172YL63_RS07165	COG0439	Biotin carboxylase
KH172YL63_RS07170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KH172YL63_RS07175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KH172YL63_RS07180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KH172YL63_RS07190	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KH172YL63_RS07195	COG2001	Belongs to the MraZ family
KH172YL63_RS07215	COG0768	penicillin binding
KH172YL63_RS07230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KH172YL63_RS07235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KH172YL63_RS07240	COG0772	Belongs to the SEDS family
KH172YL63_RS07245	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KH172YL63_RS07250	COG3879	Bacterial protein of unknown function (DUF881)
KH172YL63_RS07255	COG3879	Bacterial protein of unknown function (DUF881)
KH172YL63_RS07260	COG3856	small basic protein
KH172YL63_RS07265	COG0849	cell division
KH172YL63_RS07270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KH172YL63_RS07280	COG1191	sigma factor activity
KH172YL63_RS07285	COG1191	sigma factor activity
KH172YL63_RS07290	COG1873	PFAM PRC-barrel domain
KH172YL63_RS07300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KH172YL63_RS07305	COG1799	cell septum assembly
KH172YL63_RS07310	COG0762	integral membrane protein
KH172YL63_RS07315	COG2302	S4 RNA-binding domain
KH172YL63_RS07320	COG3599	regulation of cell shape
KH172YL63_RS07335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KH172YL63_RS07340	COG0564	pseudouridine synthase activity
KH172YL63_RS07345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KH172YL63_RS07350	COG2233	PERMEase
KH172YL63_RS07355	COG0540	Belongs to the ATCase OTCase family
KH172YL63_RS07360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KH172YL63_RS07370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KH172YL63_RS07375	COG0543	2 iron, 2 sulfur cluster binding
KH172YL63_RS07380	COG0167	dihydroorotate dehydrogenase activity
KH172YL63_RS07400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KH172YL63_RS07405	COG1561	YicC-like family, N-terminal region
KH172YL63_RS07415	COG0194	GDP metabolic process
KH172YL63_RS07425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KH172YL63_RS07430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KH172YL63_RS07435	COG0242	peptide deformylase activity
KH172YL63_RS07440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KH172YL63_RS07445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KH172YL63_RS07445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KH172YL63_RS07450	COG0631	protein serine/threonine phosphatase activity
KH172YL63_RS07455	COG2815	serine threonine protein kinase
KH172YL63_RS07455	COG0515	serine threonine protein kinase
KH172YL63_RS07465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KH172YL63_RS07470	COG1564	THIamine pyrophosphokinase
KH172YL63_RS07480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KH172YL63_RS07485	COG1302	Protein conserved in bacteria
KH172YL63_RS07490	COG1461	Dihydroxyacetone kinase
KH172YL63_RS07495	COG1760	l-serine dehydratase
KH172YL63_RS07500	COG1760	l-serine dehydratase
KH172YL63_RS07505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KH172YL63_RS07510	COG1349	DNA-binding transcription factor activity
KH172YL63_RS07515	COG0416	fatty acid biosynthetic process
KH172YL63_RS07520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KH172YL63_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS07530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KH172YL63_RS07540	COG1196	nuclear chromosome segregation
KH172YL63_RS07545	COG0552	protein localization to endoplasmic reticulum
KH172YL63_RS07550	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KH172YL63_RS07555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KH172YL63_RS07560	COG0228	four-way junction DNA binding
KH172YL63_RS07565	COG1837	Belongs to the UPF0109 family
KH172YL63_RS07575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KH172YL63_RS07580	COG0336	Belongs to the RNA methyltransferase TrmD family
KH172YL63_RS07585	COG0335	large ribosomal subunit rRNA binding
KH172YL63_RS07600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KH172YL63_RS07610	COG2257	FlhB HrpN YscU SpaS Family
KH172YL63_RS07620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KH172YL63_RS07625	COG0758	DNA mediated transformation
KH172YL63_RS07630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KH172YL63_RS07635	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KH172YL63_RS07640	COG4974	Belongs to the 'phage' integrase family
KH172YL63_RS07645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KH172YL63_RS07650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KH172YL63_RS07655	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KH172YL63_RS07660	COG1815	bacterial-type flagellum-dependent cell motility
KH172YL63_RS07665	COG1558	bacterial-type flagellum-dependent cell motility
KH172YL63_RS07670	COG1677	Flagellar hook-basal body complex protein FliE
KH172YL63_RS07675	COG1766	The M ring may be actively involved in energy transduction
KH172YL63_RS07680	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KH172YL63_RS07690	COG1157	protein secretion by the type III secretion system
KH172YL63_RS07695	COG2882	bacterial-type flagellum organization
KH172YL63_RS07705	COG3144	bacterial-type flagellum assembly
KH172YL63_RS07710	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KH172YL63_RS07725	COG1582	Flagellar protein (FlbD)
KH172YL63_RS07730	COG1580	Controls the rotational direction of flagella during chemotaxis
KH172YL63_RS07735	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KH172YL63_RS07740	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KH172YL63_RS07740	COG1776	CheC inhibitor of MCP methylation
KH172YL63_RS07745	COG2201	protein-glutamate methylesterase activity
KH172YL63_RS07750	COG3190	flagellar
KH172YL63_RS07755	COG1338	Plays a role in the flagellum-specific transport system
KH172YL63_RS07760	COG1987	bacterial-type flagellum assembly
KH172YL63_RS07765	COG1684	flagellar biosynthetic protein fliR
KH172YL63_RS07770	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KH172YL63_RS07775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KH172YL63_RS07785	COG0455	bacterial-type flagellum organization
KH172YL63_RS07790	COG2201	protein-glutamate methylesterase activity
KH172YL63_RS07795	COG2198	Histidine kinase
KH172YL63_RS07795	COG0643	Histidine kinase
KH172YL63_RS07800	COG0835	chemotaxis
KH172YL63_RS07805	COG1776	CheC inhibitor of MCP methylation
KH172YL63_RS07810	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KH172YL63_RS07815	COG1191	sigma factor activity
KH172YL63_RS07830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KH172YL63_RS07845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KH172YL63_RS07850	COG4589	Belongs to the CDS family
KH172YL63_RS07860	COG0750	zinc metalloprotease
KH172YL63_RS07870	COG2176	DNA-directed DNA polymerase activity
KH172YL63_RS07875	COG0779	Required for maturation of 30S ribosomal subunits
KH172YL63_RS07880	COG0195	Participates in both transcription termination and antitermination
KH172YL63_RS07885	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KH172YL63_RS07890	COG1358	cellular component organization or biogenesis
KH172YL63_RS07895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KH172YL63_RS07900	COG1550	Protein conserved in bacteria
KH172YL63_RS07905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KH172YL63_RS07910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KH172YL63_RS07915	COG0196	riboflavin kinase activity
KH172YL63_RS07920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KH172YL63_RS07925	COG1185	polyribonucleotide nucleotidyltransferase activity
KH172YL63_RS07930	COG0726	polysaccharide deacetylase
KH172YL63_RS07935	COG0612	Peptidase, M16
KH172YL63_RS07940	COG1873	PFAM PRC-barrel domain
KH172YL63_RS07945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KH172YL63_RS07950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KH172YL63_RS07955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KH172YL63_RS07960	COG0527	aspartate kinase activity
KH172YL63_RS07970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KH172YL63_RS07975	COG0740	serine-type endopeptidase activity
KH172YL63_RS07985	COG1674	ftsk spoiiie
KH172YL63_RS07985	COG4980	gas vesicle protein
KH172YL63_RS07990	COG2188	Transcriptional regulator
KH172YL63_RS08015	COG0612	Peptidase, M16
KH172YL63_RS08020	COG0612	Peptidase, M16
KH172YL63_RS08025	COG0300	oxidoreductase activity
KH172YL63_RS08040	COG1426	Protein conserved in bacteria
KH172YL63_RS08045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KH172YL63_RS08050	COG1058	Belongs to the CinA family
KH172YL63_RS08050	COG1546	Belongs to the CinA family
KH172YL63_RS08055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KH172YL63_RS08065	COG1692	metallophosphoesterase
KH172YL63_RS08070	COG2359	stage V sporulation protein S
KH172YL63_RS08080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KH172YL63_RS08080	COG0674	pyruvate-flavodoxin oxidoreductase activity
KH172YL63_RS08085	COG1013	pyruvate-flavodoxin oxidoreductase activity
KH172YL63_RS08110	COG1216	Glycosyl transferase, family 2
KH172YL63_RS08135	COG0438	transferase activity, transferring glycosyl groups
KH172YL63_RS08145	COG1086	Polysaccharide biosynthesis protein
KH172YL63_RS08170	COG0529	Catalyzes the synthesis of activated sulfate
KH172YL63_RS08175	COG0471	metal ion transport
KH172YL63_RS08175	COG3273	potassium ion transport
KH172YL63_RS08180	COG2046	Belongs to the sulfate adenylyltransferase family
KH172YL63_RS08195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KH172YL63_RS08200	COG4550	Control of competence regulator ComK, YlbF/YmcA
KH172YL63_RS08210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KH172YL63_RS08210	COG0551	DNA topoisomerase type I activity
KH172YL63_RS08220	COG1966	Carbon starvation protein
KH172YL63_RS08265	COG1012	belongs to the aldehyde dehydrogenase family
KH172YL63_RS08270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KH172YL63_RS08275	COG2720	vancomycin resistance protein
KH172YL63_RS08290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KH172YL63_RS08295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KH172YL63_RS08300	COG0277	FAD linked oxidase domain protein
KH172YL63_RS08305	COG2271	Major facilitator Superfamily
KH172YL63_RS08325	COG0464	growth
KH172YL63_RS08330	COG2860	membrane
KH172YL63_RS08335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KH172YL63_RS08340	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KH172YL63_RS08345	COG0789	Transcriptional regulator
KH172YL63_RS08350	COG0174	glutamine synthetase
KH172YL63_RS08355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KH172YL63_RS08360	COG1388	LysM domain
KH172YL63_RS08365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KH172YL63_RS08370	COG4224	UPF0291 protein
KH172YL63_RS08385	COG3763	UPF0154 protein
KH172YL63_RS08480	COG0515	serine threonine protein kinase
KH172YL63_RS08480	COG0457	Tetratricopeptide repeat
KH172YL63_RS08530	COG0785	Cytochrome C biogenesis protein
KH172YL63_RS08535	COG2201	protein-glutamate methylesterase activity
KH172YL63_RS08540	COG4846	Membrane protein involved in cytochrome C biogenesis
KH172YL63_RS08545	COG1994	Peptidase M50
KH172YL63_RS08555	COG3852	Histidine kinase
KH172YL63_RS08585	COG0419	ATPase involved in DNA repair
KH172YL63_RS08610	COG5146	pantothenate kinase activity
KH172YL63_RS08615	COG1999	signal sequence binding
KH172YL63_RS08620	COG1247	-acetyltransferase
KH172YL63_RS08650	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KH172YL63_RS08665	COG1063	alcohol dehydrogenase
KH172YL63_RS08670	COG0626	cystathionine gamma-synthase activity
KH172YL63_RS08675	COG0626	cystathionine gamma-synthase activity
KH172YL63_RS08680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KH172YL63_RS08680	COG0646	methionine synthase
KH172YL63_RS08685	COG1410	methionine synthase
KH172YL63_RS08685	COG0646	methionine synthase
KH172YL63_RS08700	COG1366	Belongs to the anti-sigma-factor antagonist family
KH172YL63_RS08705	COG0346	lactoylglutathione lyase activity
KH172YL63_RS08710	COG0400	carboxylic ester hydrolase activity
KH172YL63_RS08725	COG2169	Transcriptional regulator
KH172YL63_RS08725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KH172YL63_RS08735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS08745	COG0584	glycerophosphoryl diester phosphodiesterase
KH172YL63_RS08760	COG2267	carboxylic ester hydrolase activity
KH172YL63_RS08765	COG5522	Integral membrane protein (intg_mem_TP0381)
KH172YL63_RS08770	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KH172YL63_RS08785	COG2205	protein histidine kinase activity
KH172YL63_RS08790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KH172YL63_RS08795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KH172YL63_RS08820	COG1183	phosphatidylcholine synthase activity
KH172YL63_RS08835	COG1695	Transcriptional regulator
KH172YL63_RS08840	COG0167	dihydroorotate dehydrogenase activity
KH172YL63_RS08850	COG0659	secondary active sulfate transmembrane transporter activity
KH172YL63_RS08875	COG2226	methyltransferase
KH172YL63_RS08885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS08895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KH172YL63_RS08900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KH172YL63_RS08910	COG2814	Major facilitator Superfamily
KH172YL63_RS08935	COG2318	DinB family
KH172YL63_RS08950	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KH172YL63_RS08955	COG1695	Transcriptional regulator
KH172YL63_RS08965	COG3386	PFAM SMP-30 Gluconolaconase
KH172YL63_RS08975	COG4122	O-methyltransferase activity
KH172YL63_RS08980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KH172YL63_RS08995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KH172YL63_RS09000	COG2239	Acts as a magnesium transporter
KH172YL63_RS09005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KH172YL63_RS09025	COG1131	(ABC) transporter
KH172YL63_RS09040	COG0477	Major facilitator Superfamily
KH172YL63_RS09045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KH172YL63_RS09050	COG1309	transcriptional regulator
KH172YL63_RS09060	COG1125	glycine betaine transport
KH172YL63_RS09060	COG0517	IMP dehydrogenase activity
KH172YL63_RS09065	COG1174	glycine betaine transport
KH172YL63_RS09075	COG1216	Glycosyl transferase, family 2
KH172YL63_RS09100	COG3655	Transcriptional regulator
KH172YL63_RS09110	COG0596	Alpha beta hydrolase
KH172YL63_RS09115	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS09155	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KH172YL63_RS09155	COG3264	Mechanosensitive ion channel
KH172YL63_RS09160	COG1597	lipid kinase activity
KH172YL63_RS09165	COG0322	excinuclease ABC activity
KH172YL63_RS09175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KH172YL63_RS09195	COG0583	DNA-binding transcription factor activity
KH172YL63_RS09200	COG0372	Belongs to the citrate synthase family
KH172YL63_RS09205	COG0346	lactoylglutathione lyase activity
KH172YL63_RS09235	COG1131	(ABC) transporter
KH172YL63_RS09240	COG0842	Transport permease protein
KH172YL63_RS09250	COG2304	oxidoreductase activity
KH172YL63_RS09275	COG3813	Protein conserved in bacteria
KH172YL63_RS09295	COG0456	acetyltransferase
KH172YL63_RS09345	COG2362	D-Aminopeptidase
KH172YL63_RS09350	COG0601	transmembrane transport
KH172YL63_RS09355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KH172YL63_RS09360	COG0444	Belongs to the ABC transporter superfamily
KH172YL63_RS09365	COG4166	transmembrane transport
KH172YL63_RS09370	COG1619	proteins homologs of microcin C7 resistance protein MccF
KH172YL63_RS09375	COG4948	Mandelate Racemase Muconate Lactonizing
KH172YL63_RS09380	COG0791	NLP P60 protein
KH172YL63_RS09385	COG4608	Belongs to the ABC transporter superfamily
KH172YL63_RS09420	COG1960	acyl-CoA dehydrogenase activity
KH172YL63_RS09435	COG2267	carboxylic ester hydrolase activity
KH172YL63_RS09440	COG0456	acetyltransferase
KH172YL63_RS09455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KH172YL63_RS09460	COG2340	Cysteine-rich secretory protein family
KH172YL63_RS09490	COG4326	sporulation control protein
KH172YL63_RS09500	COG4264	IucA IucC family
KH172YL63_RS09515	COG0019	diaminopimelate decarboxylase activity
KH172YL63_RS09525	COG0789	Transcriptional regulator
KH172YL63_RS09530	COG1253	flavin adenine dinucleotide binding
KH172YL63_RS09550	COG1619	proteins homologs of microcin C7 resistance protein MccF
KH172YL63_RS09560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KH172YL63_RS09570	COG0456	acetyltransferase
KH172YL63_RS09570	COG1214	PFAM Peptidase M22, glycoprotease
KH172YL63_RS09580	COG2309	aminopeptidase activity
KH172YL63_RS09595	COG1349	DNA-binding transcription factor activity
KH172YL63_RS09600	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KH172YL63_RS09605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KH172YL63_RS09615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KH172YL63_RS09630	COG0006	proline dipeptidase activity
KH172YL63_RS09640	COG4191	Histidine kinase
KH172YL63_RS09650	COG1380	Effector of murein hydrolase LrgA
KH172YL63_RS09655	COG1346	cytolysis
KH172YL63_RS09665	COG0024	Methionine aminopeptidase
KH172YL63_RS09670	COG0840	transmembrane signaling receptor activity
KH172YL63_RS09675	COG3584	3D domain protein
KH172YL63_RS09675	COG1388	LysM domain
KH172YL63_RS09680	COG3584	3D domain protein
KH172YL63_RS09680	COG1388	LysM domain
KH172YL63_RS09685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KH172YL63_RS09700	COG0840	transmembrane signaling receptor activity
KH172YL63_RS09730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KH172YL63_RS09735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KH172YL63_RS09755	COG0824	Thioesterase
KH172YL63_RS09765	COG4841	protein insertion into membrane
KH172YL63_RS09775	COG2843	Capsule synthesis protein
KH172YL63_RS09780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KH172YL63_RS09785	COG2233	PERMEase
KH172YL63_RS09790	COG1125	glycine betaine transport
KH172YL63_RS09790	COG0517	IMP dehydrogenase activity
KH172YL63_RS09795	COG1174	glycine betaine transport
KH172YL63_RS09800	COG1732	Glycine betaine
KH172YL63_RS09805	COG1832	CoA-binding protein
KH172YL63_RS09810	COG0187	DNA topoisomerase II activity
KH172YL63_RS09815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KH172YL63_RS09820	COG1115	amino acid carrier protein
KH172YL63_RS09860	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
KH172YL63_RS09865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KH172YL63_RS09875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KH172YL63_RS09880	COG0529	Catalyzes the synthesis of activated sulfate
KH172YL63_RS09890	COG0306	phosphate transporter
KH172YL63_RS09910	COG2030	dehydratase
KH172YL63_RS09915	COG0352	thiamine-phosphate diphosphorylase activity
KH172YL63_RS09920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KH172YL63_RS09925	COG2022	thiamine diphosphate biosynthetic process
KH172YL63_RS09930	COG2104	thiamine diphosphate biosynthetic process
KH172YL63_RS09935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KH172YL63_RS09940	COG0352	thiamine-phosphate diphosphorylase activity
KH172YL63_RS09950	COG1122	ATPase activity
KH172YL63_RS09955	COG4721	ABC-type cobalt transport system, permease component
KH172YL63_RS09960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KH172YL63_RS09965	COG2197	response regulator
KH172YL63_RS09970	COG4585	Histidine kinase
KH172YL63_RS10010	COG0708	Exodeoxyribonuclease III
KH172YL63_RS10025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KH172YL63_RS10035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KH172YL63_RS10045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KH172YL63_RS10050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KH172YL63_RS10060	COG1011	Hydrolase
KH172YL63_RS10080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KH172YL63_RS10095	COG0693	protein deglycase activity
KH172YL63_RS10100	COG2084	Dehydrogenase
KH172YL63_RS10115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KH172YL63_RS10115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS10120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KH172YL63_RS10120	COG0425	Belongs to the sulfur carrier protein TusA family
KH172YL63_RS10130	COG0745	RESPONSE REGULATOR receiver
KH172YL63_RS10135	COG5002	protein histidine kinase activity
KH172YL63_RS10140	COG4086	secreted protein
KH172YL63_RS10145	COG4191	Histidine kinase
KH172YL63_RS10150	COG0730	response to heat
KH172YL63_RS10155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KH172YL63_RS10155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS10160	COG0425	Belongs to the sulfur carrier protein TusA family
KH172YL63_RS10160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KH172YL63_RS10165	COG2210	Belongs to the sulfur carrier protein TusA family
KH172YL63_RS10170	COG0425	Belongs to the sulfur carrier protein TusA family
KH172YL63_RS10175	COG1937	Protein conserved in bacteria
KH172YL63_RS10185	COG0003	Pfam Anion-transporting ATPase
KH172YL63_RS10195	COG1966	Carbon starvation protein
KH172YL63_RS10230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KH172YL63_RS10240	COG0517	IMP dehydrogenase activity
KH172YL63_RS10240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KH172YL63_RS10245	COG2176	DNA-directed DNA polymerase activity
KH172YL63_RS10250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KH172YL63_RS10255	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KH172YL63_RS10280	COG2096	Adenosyltransferase
KH172YL63_RS10295	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KH172YL63_RS10305	COG1120	ATPase activity
KH172YL63_RS10310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KH172YL63_RS10315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KH172YL63_RS10320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KH172YL63_RS10335	COG0463	Glycosyl transferase, family 2
KH172YL63_RS10350	COG2996	Protein conserved in bacteria
KH172YL63_RS10355	COG2252	PERMEase
KH172YL63_RS10360	COG2223	nitrite transmembrane transporter activity
KH172YL63_RS10365	COG3973	AAA domain
KH172YL63_RS10385	COG4807	Protein conserved in bacteria
KH172YL63_RS10420	COG1181	Belongs to the D-alanine--D-alanine ligase family
KH172YL63_RS10425	COG0840	transmembrane signaling receptor activity
KH172YL63_RS10430	COG3852	Histidine kinase
KH172YL63_RS10470	COG0662	Cupin 2, conserved barrel domain protein
KH172YL63_RS10475	COG2323	membrane
KH172YL63_RS10480	COG1132	(ABC) transporter
KH172YL63_RS10485	COG1132	(ABC) transporter
KH172YL63_RS10500	COG0300	oxidoreductase activity
KH172YL63_RS10510	COG0385	Bile acid
KH172YL63_RS10520	COG1454	alcohol dehydrogenase
KH172YL63_RS10525	COG2188	Transcriptional regulator
KH172YL63_RS10530	COG3773	Cell wall hydrolase
KH172YL63_RS10565	COG1393	Belongs to the ArsC family
KH172YL63_RS10580	COG0384	phenazine biosynthesis protein PhzF
KH172YL63_RS10625	COG1595	DNA-templated transcription, initiation
KH172YL63_RS10640	COG0584	glycerophosphoryl diester phosphodiesterase
KH172YL63_RS10655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KH172YL63_RS10660	COG3739	integral membrane protein
KH172YL63_RS10735	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
KH172YL63_RS10760	COG1595	DNA-templated transcription, initiation
KH172YL63_RS10770	COG5002	protein histidine kinase activity
KH172YL63_RS10785	COG3706	GGDEF domain
KH172YL63_RS10810	COG2832	Protein of unknown function (DUF454)
KH172YL63_RS10895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KH172YL63_RS10900	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KH172YL63_RS10905	COG0640	Transcriptional regulator
KH172YL63_RS11005	COG1131	(ABC) transporter
KH172YL63_RS11015	COG1595	DNA-templated transcription, initiation
KH172YL63_RS11045	COG0546	phosphoglycolate phosphatase activity
KH172YL63_RS11075	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS11115	COG0346	lactoylglutathione lyase activity
KH172YL63_RS11190	COG0305	Participates in initiation and elongation during chromosome replication
KH172YL63_RS11220	COG0494	nUDIX hydrolase
KH172YL63_RS11225	COG1061	Type III restriction enzyme res subunit
KH172YL63_RS11240	COG1396	sequence-specific DNA binding
KH172YL63_RS11265	COG0473	3-isopropylmalate dehydrogenase activity
KH172YL63_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS11285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KH172YL63_RS11290	COG0183	Belongs to the thiolase family
KH172YL63_RS11295	COG1960	acyl-CoA dehydrogenase activity
KH172YL63_RS11300	COG1024	Enoyl-CoA hydratase
KH172YL63_RS11305	COG1250	3-hydroxyacyl-CoA dehydrogenase
KH172YL63_RS11315	COG2358	TRAP transporter, solute receptor (TAXI family
KH172YL63_RS11325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KH172YL63_RS11335	COG3290	protein histidine kinase activity
KH172YL63_RS11335	COG3829	transcription factor binding
KH172YL63_RS11380	COG3853	Toxic anion resistance protein (TelA)
KH172YL63_RS11395	COG1358	cellular component organization or biogenesis
KH172YL63_RS11410	COG0861	Integral membrane protein TerC family
KH172YL63_RS11415	COG2310	stress, protein
KH172YL63_RS11420	COG2310	stress, protein
KH172YL63_RS11425	COG2310	stress, protein
KH172YL63_RS11445	COG2318	DinB family
KH172YL63_RS11450	COG0412	Dienelactone hydrolase
KH172YL63_RS11485	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KH172YL63_RS11505	COG2205	protein histidine kinase activity
KH172YL63_RS11510	COG0697	spore germination
KH172YL63_RS11530	COG1309	transcriptional regulator
KH172YL63_RS11535	COG2814	Major facilitator Superfamily
KH172YL63_RS11560	COG1131	(ABC) transporter
KH172YL63_RS11605	COG0446	pyridine nucleotide-disulphide oxidoreductase
KH172YL63_RS11630	COG2814	Major facilitator Superfamily
KH172YL63_RS11635	COG0450	alkyl hydroperoxide reductase
KH172YL63_RS11640	COG3634	alkyl hydroperoxide reductase activity
KH172YL63_RS11670	COG0318	PFAM AMP-dependent synthetase and ligase
KH172YL63_RS11675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KH172YL63_RS11680	COG0183	Belongs to the thiolase family
KH172YL63_RS11685	COG1960	acyl-CoA dehydrogenase activity
KH172YL63_RS11690	COG0318	PFAM AMP-dependent synthetase and ligase
KH172YL63_RS11695	COG3290	protein histidine kinase activity
KH172YL63_RS11695	COG3829	transcription factor binding
KH172YL63_RS11725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS11730	COG0537	adenosine 5'-monophosphoramidase activity
KH172YL63_RS11750	COG0456	acetyltransferase
KH172YL63_RS11755	COG2267	carboxylic ester hydrolase activity
KH172YL63_RS11770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KH172YL63_RS11790	COG0604	alcohol dehydrogenase
KH172YL63_RS11810	COG1131	(ABC) transporter
KH172YL63_RS11865	COG1164	Oligoendopeptidase f
KH172YL63_RS11885	COG0702	epimerase
KH172YL63_RS11930	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS11940	COG1595	DNA-templated transcription, initiation
KH172YL63_RS11945	COG0500	methyltransferase
KH172YL63_RS11980	COG1309	transcriptional regulator
KH172YL63_RS11995	COG0579	oxidoreductase
KH172YL63_RS12005	COG2186	Transcriptional regulator
KH172YL63_RS12020	COG1131	(ABC) transporter
KH172YL63_RS12045	COG4213	ABC transporter substrate-binding protein
KH172YL63_RS12050	COG2207	Transcriptional regulator
KH172YL63_RS12050	COG4753	response regulator
KH172YL63_RS12055	COG2972	Histidine kinase
KH172YL63_RS12065	COG1172	Belongs to the binding-protein-dependent transport system permease family
KH172YL63_RS12070	COG1129	ABC transporter
KH172YL63_RS12075	COG4213	ABC transporter substrate-binding protein
KH172YL63_RS12095	COG1193	negative regulation of DNA recombination
KH172YL63_RS12105	COG3339	Conserved Protein
KH172YL63_RS12110	COG0488	(ABC) transporter
KH172YL63_RS12115	COG0514	ATP-dependent DNA helicase (RecQ)
KH172YL63_RS12165	COG1686	Belongs to the peptidase S11 family
KH172YL63_RS12170	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
KH172YL63_RS12175	COG3853	Toxic anion resistance protein (TelA)
KH172YL63_RS12190	COG4548	von Willebrand factor, type A
KH172YL63_RS12195	COG0714	Associated with various cellular activities
KH172YL63_RS12200	COG0454	-acetyltransferase
KH172YL63_RS12200	COG0456	acetyltransferase
KH172YL63_RS12210	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
KH172YL63_RS12225	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
KH172YL63_RS12225	COG2105	PFAM AIG2 family protein
KH172YL63_RS12230	COG0318	PFAM AMP-dependent synthetase and ligase
KH172YL63_RS12240	COG0508	dehydrogenase complex catalyzes the overall conversion of
KH172YL63_RS12245	COG0567	Dehydrogenase, E1 component
KH172YL63_RS12255	COG5002	protein histidine kinase activity
KH172YL63_RS12260	COG0745	RESPONSE REGULATOR receiver
KH172YL63_RS12265	COG2814	Major facilitator Superfamily
KH172YL63_RS12280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KH172YL63_RS12295	COG0432	Pfam Uncharacterised protein family UPF0047
KH172YL63_RS12300	COG3011	Protein conserved in bacteria
KH172YL63_RS12305	COG0406	alpha-ribazole phosphatase activity
KH172YL63_RS12310	COG1366	Belongs to the anti-sigma-factor antagonist family
KH172YL63_RS12370	COG2076	Multidrug Resistance protein
KH172YL63_RS12385	COG0697	spore germination
KH172YL63_RS12390	COG3541	Predicted nucleotidyltransferase
KH172YL63_RS12395	COG0628	permease
KH172YL63_RS12410	COG3340	Belongs to the peptidase S51 family
KH172YL63_RS12415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KH172YL63_RS12420	COG2356	endonuclease I
KH172YL63_RS12430	COG1278	Cold shock
KH172YL63_RS12440	COG1970	mechanosensitive ion channel activity
KH172YL63_RS12495	COG2226	methyltransferase
KH172YL63_RS12500	COG1619	proteins homologs of microcin C7 resistance protein MccF
KH172YL63_RS12530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KH172YL63_RS12535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KH172YL63_RS12535	COG0512	Glutamine amidotransferase of anthranilate synthase
KH172YL63_RS12550	COG4145	pantothenate transmembrane transporter activity
KH172YL63_RS12565	COG0671	phosphoesterase, PA-phosphatase related
KH172YL63_RS12570	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KH172YL63_RS12575	COG3285	dna ligase
KH172YL63_RS12575	COG1793	dna ligase
KH172YL63_RS12590	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KH172YL63_RS12605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KH172YL63_RS12605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KH172YL63_RS12610	COG0307	riboflavin synthase, alpha
KH172YL63_RS12615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KH172YL63_RS12615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KH172YL63_RS12630	COG4667	esterase of the alpha-beta hydrolase superfamily
KH172YL63_RS12645	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KH172YL63_RS12650	COG1131	(ABC) transporter
KH172YL63_RS12670	COG0586	Pfam SNARE associated Golgi protein
KH172YL63_RS12675	COG1228	amidohydrolase
KH172YL63_RS12695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KH172YL63_RS12705	COG1215	transferase activity, transferring glycosyl groups
KH172YL63_RS12720	COG0534	Mate efflux family protein
KH172YL63_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS12730	COG2340	Cysteine-rich secretory protein family
KH172YL63_RS12745	COG0477	Major facilitator Superfamily
KH172YL63_RS12750	COG1846	Transcriptional regulator
KH172YL63_RS12765	COG0523	cobalamin synthesis protein
KH172YL63_RS12775	COG0793	Belongs to the peptidase S41A family
KH172YL63_RS12775	COG3409	Peptidoglycan-binding domain 1 protein
KH172YL63_RS12780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KH172YL63_RS12800	COG0697	spore germination
KH172YL63_RS12805	COG1876	peptidase activity
KH172YL63_RS12825	COG4326	sporulation control protein
KH172YL63_RS12830	COG0515	serine threonine protein kinase
KH172YL63_RS12865	COG4479	Belongs to the UPF0346 family
KH172YL63_RS12875	COG1509	lysine 2,3-aminomutase activity
KH172YL63_RS12885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KH172YL63_RS12890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KH172YL63_RS12895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KH172YL63_RS12900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KH172YL63_RS12905	COG0840	transmembrane signaling receptor activity
KH172YL63_RS12925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KH172YL63_RS12930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KH172YL63_RS12950	COG2755	lipolytic protein G-D-S-L family
KH172YL63_RS12965	COG1307	EDD domain protein, DegV family
KH172YL63_RS12975	COG2135	peptidase activity
KH172YL63_RS12980	COG1272	protein, Hemolysin III
KH172YL63_RS12985	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KH172YL63_RS12990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KH172YL63_RS13005	COG2136	Putative SAM-dependent methyltransferase
KH172YL63_RS13005	COG2521	methyltransferase
KH172YL63_RS13015	COG1413	lyase activity
KH172YL63_RS13020	COG0488	(ABC) transporter
KH172YL63_RS13025	COG1418	mRNA catabolic process
KH172YL63_RS13030	COG1307	EDD domain protein, DegV family
KH172YL63_RS13045	COG2226	methyltransferase
KH172YL63_RS13055	COG1321	iron dependent repressor
KH172YL63_RS13060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KH172YL63_RS13065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KH172YL63_RS13065	COG1321	iron dependent repressor
KH172YL63_RS13070	COG1121	(ABC) transporter
KH172YL63_RS13075	COG0803	Belongs to the bacterial solute-binding protein 9 family
KH172YL63_RS13080	COG1278	Cold shock
KH172YL63_RS13090	COG0328	RNA-DNA hybrid ribonuclease activity
KH172YL63_RS13100	COG0328	RNA-DNA hybrid ribonuclease activity
KH172YL63_RS13120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KH172YL63_RS13125	COG2897	thiosulfate sulfurtransferase activity
KH172YL63_RS13135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KH172YL63_RS13140	COG1755	Isoprenylcysteine carboxyl methyltransferase
KH172YL63_RS13145	COG3424	synthase
KH172YL63_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS13165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KH172YL63_RS13170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KH172YL63_RS13180	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KH172YL63_RS13185	COG1199	ATP-dependent helicase activity
KH172YL63_RS13195	COG0116	Belongs to the methyltransferase superfamily
KH172YL63_RS13220	COG3359	exonuclease
KH172YL63_RS13225	COG1111	helicase
KH172YL63_RS13225	COG1205	dead DEAH box helicase
KH172YL63_RS13265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KH172YL63_RS13265	COG4499	WXG100 protein secretion system (Wss), protein YukC
KH172YL63_RS13280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KH172YL63_RS13285	COG3935	DnaD domain protein
KH172YL63_RS13290	COG0017	Asparaginyl-tRNA synthetase
KH172YL63_RS13295	COG0436	Aminotransferase
KH172YL63_RS13315	COG1199	ATP-dependent helicase activity
KH172YL63_RS13315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KH172YL63_RS13320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KH172YL63_RS13325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KH172YL63_RS13340	COG0617	tRNA 3'-terminal CCA addition
KH172YL63_RS13345	COG0438	transferase activity, transferring glycosyl groups
KH172YL63_RS13350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KH172YL63_RS13355	COG1803	Methylglyoxal synthase
KH172YL63_RS13365	COG1694	Mazg nucleotide pyrophosphohydrolase
KH172YL63_RS13370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KH172YL63_RS13375	COG2738	Putative neutral zinc metallopeptidase
KH172YL63_RS13385	COG4347	Protein of unknown function (DUF1405)
KH172YL63_RS13395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KH172YL63_RS13410	COG5582	Belongs to the UPF0302 family
KH172YL63_RS13415	COG0457	Tetratricopeptide repeat
KH172YL63_RS13425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KH172YL63_RS13430	COG0287	Prephenate dehydrogenase
KH172YL63_RS13435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KH172YL63_RS13440	COG4401	Chorismate mutase type I
KH172YL63_RS13445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KH172YL63_RS13450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KH172YL63_RS13455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KH172YL63_RS13460	COG0105	UTP biosynthetic process
KH172YL63_RS13465	COG0142	geranyltranstransferase activity
KH172YL63_RS13470	COG2226	methyltransferase
KH172YL63_RS13475	COG0142	geranyltranstransferase activity
KH172YL63_RS13485	COG0302	gtp cyclohydrolase
KH172YL63_RS13490	COG0776	regulation of translation
KH172YL63_RS13495	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KH172YL63_RS13515	COG1160	GTP binding
KH172YL63_RS13540	COG1304	FMN binding
KH172YL63_RS13545	COG0539	negative regulation of cytoplasmic translation
KH172YL63_RS13550	COG0204	Acyl-transferase
KH172YL63_RS13555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KH172YL63_RS13565	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
KH172YL63_RS13570	COG2959	enzyme of heme biosynthesis
KH172YL63_RS13575	COG3409	Peptidoglycan-binding domain 1 protein
KH172YL63_RS13575	COG3773	Cell wall hydrolase
KH172YL63_RS13580	COG2339	peptidase activity
KH172YL63_RS13585	COG0252	asparaginase activity
KH172YL63_RS13590	COG0492	ferredoxin-NADP+ reductase activity
KH172YL63_RS13595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KH172YL63_RS13605	COG0789	Transcriptional regulator
KH172YL63_RS13610	COG1408	metallophosphoesterase
KH172YL63_RS13635	COG3546	catalase activity
KH172YL63_RS13645	COG0438	transferase activity, transferring glycosyl groups
KH172YL63_RS13650	COG0671	phosphoesterase, PA-phosphatase related
KH172YL63_RS13655	COG1388	LysM domain
KH172YL63_RS13660	COG1266	CAAX protease self-immunity
KH172YL63_RS13665	COG0514	ATP-dependent DNA helicase (RecQ)
KH172YL63_RS13670	COG4955	Helix-turn-helix domain
KH172YL63_RS13675	COG1141	Ferredoxin
KH172YL63_RS13680	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KH172YL63_RS13695	COG1595	DNA-templated transcription, initiation
KH172YL63_RS13700	COG5002	protein histidine kinase activity
KH172YL63_RS13705	COG0745	RESPONSE REGULATOR receiver
KH172YL63_RS13710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KH172YL63_RS13715	COG1333	cytochrome c biogenesis protein
KH172YL63_RS13720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KH172YL63_RS13725	COG1187	pseudouridine synthase activity
KH172YL63_RS13730	COG0700	Nucleoside recognition
KH172YL63_RS13735	COG2715	membrane protein required for spore maturation
KH172YL63_RS13740	COG1686	Belongs to the peptidase S11 family
KH172YL63_RS13745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KH172YL63_RS13750	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KH172YL63_RS13755	COG1547	Domain of unknown function (DUF309)
KH172YL63_RS13770	COG0697	spore germination
KH172YL63_RS13810	COG1686	Belongs to the peptidase S11 family
KH172YL63_RS13825	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KH172YL63_RS13830	COG4974	Belongs to the 'phage' integrase family
KH172YL63_RS13840	COG0735	belongs to the Fur family
KH172YL63_RS13845	COG1300	Membrane
KH172YL63_RS13855	COG0494	nUDIX hydrolase
KH172YL63_RS13865	COG0667	Aldo Keto reductase
KH172YL63_RS13870	COG0456	acetyltransferase
KH172YL63_RS13870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KH172YL63_RS13880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KH172YL63_RS13885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KH172YL63_RS13890	COG0183	Belongs to the thiolase family
KH172YL63_RS13895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KH172YL63_RS13900	COG1073	alpha beta
KH172YL63_RS13910	COG4918	Iron-sulphur cluster biosynthesis
KH172YL63_RS13925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KH172YL63_RS13935	COG4975	Glucose uptake
KH172YL63_RS13950	COG0300	oxidoreductase activity
KH172YL63_RS13955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS13960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KH172YL63_RS13965	COG1902	pentaerythritol trinitrate reductase activity
KH172YL63_RS13980	COG1234	tRNA 3'-trailer cleavage
KH172YL63_RS13985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KH172YL63_RS13990	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KH172YL63_RS13995	COG1733	regulation of RNA biosynthetic process
KH172YL63_RS14000	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KH172YL63_RS14005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KH172YL63_RS14030	COG0456	acetyltransferase
KH172YL63_RS14030	COG0454	-acetyltransferase
KH172YL63_RS14035	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KH172YL63_RS14040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KH172YL63_RS14050	COG2195	Cleaves the N-terminal amino acid of tripeptides
KH172YL63_RS14055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KH172YL63_RS14060	COG0346	lactoylglutathione lyase activity
KH172YL63_RS14070	COG1376	ErfK ybiS ycfS ynhG family protein
KH172YL63_RS14075	COG4129	membrane
KH172YL63_RS14080	COG1126	abc transporter atp-binding protein
KH172YL63_RS14085	COG0765	amino acid transport
KH172YL63_RS14090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KH172YL63_RS14100	COG1703	isobutyryl-CoA mutase activity
KH172YL63_RS14105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KH172YL63_RS14105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KH172YL63_RS14110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KH172YL63_RS14115	COG4412	M6 family metalloprotease domain protein
KH172YL63_RS14115	COG1404	Belongs to the peptidase S8 family
KH172YL63_RS14120	COG0508	dehydrogenase complex catalyzes the overall conversion of
KH172YL63_RS14125	COG0022	dehydrogenase e1 component
KH172YL63_RS14130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KH172YL63_RS14135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KH172YL63_RS14140	COG3426	butyrate kinase activity
KH172YL63_RS14150	COG0280	phosphate acetyltransferase
KH172YL63_RS14155	COG3290	protein histidine kinase activity
KH172YL63_RS14155	COG3829	transcription factor binding
KH172YL63_RS14165	COG0584	glycerophosphoryl diester phosphodiesterase
KH172YL63_RS14180	COG0750	zinc metalloprotease
KH172YL63_RS14185	COG0497	DNA recombination
KH172YL63_RS14190	COG1438	arginine binding
KH172YL63_RS14195	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KH172YL63_RS14200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KH172YL63_RS14215	COG1722	exodeoxyribonuclease VII activity
KH172YL63_RS14220	COG1570	exodeoxyribonuclease VII activity
KH172YL63_RS14225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KH172YL63_RS14235	COG1302	Protein conserved in bacteria
KH172YL63_RS14240	COG0439	Biotin carboxylase
KH172YL63_RS14245	COG0511	ligase activity, forming carbon-carbon bonds
KH172YL63_RS14285	COG3854	ATPases associated with a variety of cellular activities
KH172YL63_RS14290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KH172YL63_RS14295	COG0006	proline dipeptidase activity
KH172YL63_RS14300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KH172YL63_RS14315	COG1752	Esterase of the alpha-beta hydrolase superfamily
KH172YL63_RS14320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KH172YL63_RS14325	COG0095	Lipoate-protein ligase
KH172YL63_RS14330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KH172YL63_RS14335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KH172YL63_RS14340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KH172YL63_RS14345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KH172YL63_RS14350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KH172YL63_RS14365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KH172YL63_RS14390	COG4537	Required for transformation and DNA binding
KH172YL63_RS14400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KH172YL63_RS14570	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KH172YL63_RS14595	COG0305	Participates in initiation and elongation during chromosome replication
KH172YL63_RS14620	COG0419	ATPase involved in DNA repair
KH172YL63_RS14640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KH172YL63_RS14655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KH172YL63_RS14715	COG2002	toxin-antitoxin pair type II binding
KH172YL63_RS14725	COG5377	YqaJ viral recombinase family
KH172YL63_RS14730	COG2843	Capsule synthesis protein
KH172YL63_RS14755	COG0840	transmembrane signaling receptor activity
KH172YL63_RS14775	COG1393	Belongs to the ArsC family
KH172YL63_RS14785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS14795	COG0011	TIGRFAM Protein of
KH172YL63_RS14810	COG1368	sulfuric ester hydrolase activity
KH172YL63_RS14815	COG1940	carbohydrate kinase activity
KH172YL63_RS14820	COG4483	Protein conserved in bacteria
KH172YL63_RS14825	COG0697	spore germination
KH172YL63_RS14835	COG0705	Rhomboid family
KH172YL63_RS14835	COG0457	Tetratricopeptide repeat
KH172YL63_RS14850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KH172YL63_RS14855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KH172YL63_RS14865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KH172YL63_RS14885	COG0704	Plays a role in the regulation of phosphate uptake
KH172YL63_RS14890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KH172YL63_RS14895	COG0581	inorganic phosphate transmembrane transporter activity
KH172YL63_RS14900	COG0573	inorganic phosphate transmembrane transporter activity
KH172YL63_RS14905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KH172YL63_RS14915	COG0477	Major facilitator Superfamily
KH172YL63_RS14925	COG2839	Protein conserved in bacteria
KH172YL63_RS14930	COG1283	sodium-dependent phosphate transmembrane transporter activity
KH172YL63_RS14935	COG5521	maltodextrose utilization protein MalA
KH172YL63_RS14940	COG0840	transmembrane signaling receptor activity
KH172YL63_RS14950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KH172YL63_RS14955	COG4709	membrane
KH172YL63_RS14960	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
KH172YL63_RS14970	COG0735	belongs to the Fur family
KH172YL63_RS14975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KH172YL63_RS14980	COG1121	(ABC) transporter
KH172YL63_RS14985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KH172YL63_RS14995	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KH172YL63_RS15000	COG0513	Belongs to the DEAD box helicase family
KH172YL63_RS15010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KH172YL63_RS15015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KH172YL63_RS15020	COG2384	SAM-dependent methyltransferase
KH172YL63_RS15025	COG2010	Cytochrome c
KH172YL63_RS15030	COG1960	acyl-CoA dehydrogenase activity
KH172YL63_RS15040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KH172YL63_RS15045	COG0358	DNA primase activity
KH172YL63_RS15050	COG1671	Belongs to the UPF0178 family
KH172YL63_RS15060	COG0517	IMP dehydrogenase activity
KH172YL63_RS15070	COG1381	Involved in DNA repair and RecF pathway recombination
KH172YL63_RS15085	COG0295	cytidine deaminase activity
KH172YL63_RS15090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KH172YL63_RS15100	COG1480	7TM receptor with intracellular HD hydrolase
KH172YL63_RS15105	COG1702	phosphate starvation-inducible protein PhoH
KH172YL63_RS15125	COG4864	UPF0365 protein
KH172YL63_RS15130	COG1030	water channel activity
KH172YL63_RS15135	COG1610	YqeY-like protein
KH172YL63_RS15145	COG1283	sodium-dependent phosphate transmembrane transporter activity
KH172YL63_RS15150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KH172YL63_RS15155	COG0366	Alpha amylase catalytic
KH172YL63_RS15160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KH172YL63_RS15165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KH172YL63_RS15180	COG0443	Heat shock 70 kDa protein
KH172YL63_RS15185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KH172YL63_RS15190	COG1420	regulation of RNA biosynthetic process
KH172YL63_RS15195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KH172YL63_RS15200	COG0481	GTPase activity
KH172YL63_RS15210	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS15220	COG0268	Binds directly to 16S ribosomal RNA
KH172YL63_RS15225	COG1466	dna polymerase III delta subunit
KH172YL63_RS15235	COG0658	competence protein
KH172YL63_RS15235	COG2333	competence protein COMEC
KH172YL63_RS15240	COG2131	deaminase
KH172YL63_RS15245	COG1555	photosystem II stabilization
KH172YL63_RS15245	COG1596	polysaccharide export
KH172YL63_RS15250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KH172YL63_RS15255	COG2226	methyltransferase
KH172YL63_RS15260	COG0799	negative regulation of ribosome biogenesis
KH172YL63_RS15265	COG1713	HD superfamily hydrolase involved in NAD metabolism
KH172YL63_RS15270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KH172YL63_RS15275	COG1534	Rna-binding protein
KH172YL63_RS15285	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KH172YL63_RS15300	COG0688	phosphatidylethanolamine metabolic process
KH172YL63_RS15305	COG1183	phosphatidylcholine synthase activity
KH172YL63_RS15325	COG0626	cystathionine gamma-synthase activity
KH172YL63_RS15330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KH172YL63_RS15335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KH172YL63_RS15340	COG2226	methyltransferase
KH172YL63_RS15355	COG0768	penicillin binding
KH172YL63_RS15360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KH172YL63_RS15365	COG0572	uridine kinase
KH172YL63_RS15380	COG4122	O-methyltransferase activity
KH172YL63_RS15385	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KH172YL63_RS15390	COG3906	Belongs to the UPF0473 family
KH172YL63_RS15400	COG4472	Bacterial protein of unknown function (DUF965)
KH172YL63_RS15410	COG0628	permease
KH172YL63_RS15425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KH172YL63_RS15440	COG1104	cysteine desulfurase activity
KH172YL63_RS15445	COG1959	2 iron, 2 sulfur cluster binding
KH172YL63_RS15450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KH172YL63_RS15460	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KH172YL63_RS15465	COG1131	(ABC) transporter
KH172YL63_RS15470	COG1131	(ABC) transporter
KH172YL63_RS15475	COG1725	Transcriptional regulator
KH172YL63_RS15490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KH172YL63_RS15500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KH172YL63_RS15505	COG0124	histidyl-tRNA synthetase
KH172YL63_RS15515	COG3103	Sh3 type 3 domain protein
KH172YL63_RS15515	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS15515	COG4991	sh3 domain protein
KH172YL63_RS15520	COG1490	D-aminoacyl-tRNA deacylase activity
KH172YL63_RS15525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KH172YL63_RS15530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KH172YL63_RS15535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KH172YL63_RS15535	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KH172YL63_RS15540	COG5416	Lipopolysaccharide assembly protein A domain
KH172YL63_RS15545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KH172YL63_RS15550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KH172YL63_RS15550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KH172YL63_RS15560	COG2244	polysaccharide biosynthetic process
KH172YL63_RS15565	COG2323	membrane
KH172YL63_RS15570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KH172YL63_RS15580	COG1862	Preprotein translocase
KH172YL63_RS15590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KH172YL63_RS15605	COG0632	four-way junction helicase activity
KH172YL63_RS15625	COG1388	LysM domain
KH172YL63_RS15635	COG0157	Belongs to the NadC ModD family
KH172YL63_RS15640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KH172YL63_RS15645	COG1104	cysteine desulfurase activity
KH172YL63_RS15650	COG1827	regulation of RNA biosynthetic process
KH172YL63_RS15655	COG0077	Prephenate dehydratase
KH172YL63_RS15660	COG4492	Belongs to the UPF0735 family
KH172YL63_RS15665	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KH172YL63_RS15670	COG3290	protein histidine kinase activity
KH172YL63_RS15675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KH172YL63_RS15680	COG2868	ribosomal protein
KH172YL63_RS15690	COG1530	ribonuclease E activity
KH172YL63_RS15695	COG1994	Peptidase M50
KH172YL63_RS15700	COG0739	heme binding
KH172YL63_RS15705	COG2894	cell division
KH172YL63_RS15710	COG0850	regulation of cytokinetic process
KH172YL63_RS15715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KH172YL63_RS15720	COG1792	Involved in formation and maintenance of cell shape
KH172YL63_RS15725	COG1077	Cell shape determining protein MreB Mrl
KH172YL63_RS15730	COG2003	Belongs to the UPF0758 family
KH172YL63_RS15765	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KH172YL63_RS15770	COG4969	Belongs to the N-Me-Phe pilin family
KH172YL63_RS15785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KH172YL63_RS15830	COG0285	dihydrofolate synthase activity
KH172YL63_RS15835	COG0525	valine-tRNA ligase activity
KH172YL63_RS15845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KH172YL63_RS15850	COG1388	LysM domain
KH172YL63_RS15850	COG1388	LysM domain
KH172YL63_RS15855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KH172YL63_RS15860	COG0113	porphobilinogen synthase activity
KH172YL63_RS15875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KH172YL63_RS15890	COG1126	abc transporter atp-binding protein
KH172YL63_RS15905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KH172YL63_RS15910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KH172YL63_RS15915	COG1067	ATP-dependent peptidase activity
KH172YL63_RS15915	COG0470	DNA polymerase III
KH172YL63_RS15925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KH172YL63_RS15930	COG0544	peptidyl-prolyl cis-trans isomerase activity
KH172YL63_RS15945	COG0622	Phosphoesterase
KH172YL63_RS15950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KH172YL63_RS15960	COG5401	PFAM Sporulation and spore germination
KH172YL63_RS15970	COG1846	Transcriptional regulator
KH172YL63_RS15975	COG2197	response regulator
KH172YL63_RS15980	COG0824	Thioesterase
KH172YL63_RS15985	COG0737	Belongs to the 5'-nucleotidase family
KH172YL63_RS15990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KH172YL63_RS15995	COG1053	succinate dehydrogenase
KH172YL63_RS16000	COG2009	succinate dehydrogenase
KH172YL63_RS16005	COG1719	4-vinyl reductase, 4VR
KH172YL63_RS16015	COG0322	excinuclease ABC activity
KH172YL63_RS16035	COG0463	Glycosyl transferase, family 2
KH172YL63_RS16060	COG3118	belongs to the thioredoxin family
KH172YL63_RS16065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KH172YL63_RS16070	COG2086	electron transfer activity
KH172YL63_RS16075	COG1024	Enoyl-CoA hydratase
KH172YL63_RS16080	COG1309	transcriptional regulator
KH172YL63_RS16085	COG0318	PFAM AMP-dependent synthetase and ligase
KH172YL63_RS16090	COG3766	membrane
KH172YL63_RS16095	COG1193	negative regulation of DNA recombination
KH172YL63_RS16100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KH172YL63_RS16100	COG1796	DNA polymerase
KH172YL63_RS16105	COG1286	toxin biosynthetic process
KH172YL63_RS16110	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KH172YL63_RS16115	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KH172YL63_RS16120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KH172YL63_RS16120	COG0072	phenylalanine-tRNA ligase activity
KH172YL63_RS16125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KH172YL63_RS16130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KH172YL63_RS16140	COG1335	isochorismatase
KH172YL63_RS16145	COG1363	Peptidase, m42
KH172YL63_RS16160	COG0398	Pfam SNARE associated Golgi protein
KH172YL63_RS16170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KH172YL63_RS16180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KH172YL63_RS16185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KH172YL63_RS16195	COG1484	DNA-dependent DNA replication
KH172YL63_RS16200	COG3611	Membrane attachment protein
KH172YL63_RS16205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KH172YL63_RS16220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KH172YL63_RS16225	COG0237	dephospho-CoA kinase activity
KH172YL63_RS16230	COG1971	Probably functions as a manganese efflux pump
KH172YL63_RS16235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KH172YL63_RS16240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KH172YL63_RS16240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KH172YL63_RS16245	COG0330	HflC and HflK could
KH172YL63_RS16250	COG0330	HflC and HflK could
KH172YL63_RS16255	COG5002	protein histidine kinase activity
KH172YL63_RS16260	COG0745	RESPONSE REGULATOR receiver
KH172YL63_RS16285	COG0538	isocitrate dehydrogenase activity
KH172YL63_RS16290	COG0372	Belongs to the citrate synthase family
KH172YL63_RS16300	COG0628	permease
KH172YL63_RS16305	COG3030	protein affecting phage T7 exclusion by the F plasmid
KH172YL63_RS16315	COG0205	6-phosphofructokinase activity
KH172YL63_RS16320	COG0825	malonyl-CoA metabolic process
KH172YL63_RS16325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KH172YL63_RS16330	COG1725	Transcriptional regulator
KH172YL63_RS16335	COG0281	malic enzyme
KH172YL63_RS16340	COG0587	DNA-directed DNA polymerase activity
KH172YL63_RS16370	COG1011	Hydrolase
KH172YL63_RS16385	COG1595	DNA-templated transcription, initiation
KH172YL63_RS16410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KH172YL63_RS16430	COG2267	carboxylic ester hydrolase activity
KH172YL63_RS16435	COG2329	Antibiotic biosynthesis monooxygenase
KH172YL63_RS16460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KH172YL63_RS16470	COG4109	DRTGG domain
KH172YL63_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS16550	COG0596	Alpha beta hydrolase
KH172YL63_RS16570	COG1879	ABC-type sugar transport system periplasmic component
KH172YL63_RS16575	COG1172	Belongs to the binding-protein-dependent transport system permease family
KH172YL63_RS16580	COG1129	ABC transporter
KH172YL63_RS16585	COG1869	D-ribose catabolic process
KH172YL63_RS16590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KH172YL63_RS16595	COG1609	Transcriptional regulator
KH172YL63_RS16605	COG2814	Major facilitator Superfamily
KH172YL63_RS16610	COG1733	regulation of RNA biosynthetic process
KH172YL63_RS16615	COG0656	L-ascorbic acid biosynthetic process
KH172YL63_RS16620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KH172YL63_RS16645	COG1464	Belongs to the NlpA lipoprotein family
KH172YL63_RS16650	COG2011	ABC-type metal ion transport system permease component
KH172YL63_RS16660	COG1285	pathogenesis
KH172YL63_RS16675	COG3220	belongs to the UPF0276 family
KH172YL63_RS16690	COG2153	protein acetylation
KH172YL63_RS16710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KH172YL63_RS16720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KH172YL63_RS16735	COG1609	Transcriptional regulator
KH172YL63_RS16810	COG0842	Transport permease protein
KH172YL63_RS16815	COG1511	domain protein
KH172YL63_RS16815	COG0842	Transport permease protein
KH172YL63_RS16820	COG1131	(ABC) transporter
KH172YL63_RS16825	COG2197	response regulator
KH172YL63_RS16830	COG4585	Histidine kinase
KH172YL63_RS16855	COG3557	Belongs to the UPF0374 family
KH172YL63_RS16870	COG0667	Aldo Keto reductase
KH172YL63_RS16875	COG2188	Transcriptional regulator
KH172YL63_RS16895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KH172YL63_RS16960	COG0165	Argininosuccinate lyase
KH172YL63_RS16965	COG0137	argininosuccinate synthase activity
KH172YL63_RS16975	COG2217	Heavy metal translocating P-type atpase
KH172YL63_RS16990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KH172YL63_RS16995	COG0827	DNA restriction-modification system
KH172YL63_RS17000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KH172YL63_RS17005	COG3874	Sporulation protein YtfJ
KH172YL63_RS17015	COG1714	RDD family
KH172YL63_RS17020	COG0616	signal peptide processing
KH172YL63_RS17025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KH172YL63_RS17035	COG2962	Rard protein
KH172YL63_RS17040	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KH172YL63_RS17050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KH172YL63_RS17060	COG0301	tRNA thio-modification
KH172YL63_RS17065	COG1104	cysteine desulfurase activity
KH172YL63_RS17070	COG1114	Component of the transport system for branched-chain amino acids
KH172YL63_RS17075	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KH172YL63_RS17080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KH172YL63_RS17085	COG1309	transcriptional regulator
KH172YL63_RS17090	COG1956	GAF domain-containing protein
KH172YL63_RS17105	COG2203	Gaf domain
KH172YL63_RS17105	COG2199	diguanylate cyclase activity
KH172YL63_RS17110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KH172YL63_RS17135	COG0747	negative chemotaxis
KH172YL63_RS17155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KH172YL63_RS17165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KH172YL63_RS17170	COG0454	-acetyltransferase
KH172YL63_RS17175	COG0517	IMP dehydrogenase activity
KH172YL63_RS17180	COG0123	including yeast histone deacetylase and acetoin utilization protein
KH172YL63_RS17190	COG3383	formate dehydrogenase (NAD+) activity
KH172YL63_RS17195	COG2427	Protein of unknown function (DUF1641)
KH172YL63_RS17205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KH172YL63_RS17215	COG1605	Chorismate mutase
KH172YL63_RS17215	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KH172YL63_RS17220	COG0849	cell division
KH172YL63_RS17240	COG4980	gas vesicle protein
KH172YL63_RS17250	COG2309	aminopeptidase activity
KH172YL63_RS17255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KH172YL63_RS17270	COG1674	ftsk spoiiie
KH172YL63_RS17275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KH172YL63_RS17280	COG4848	Belongs to the UPF0354 family
KH172YL63_RS17285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KH172YL63_RS17305	COG3104	oligopeptide transport
KH172YL63_RS17310	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KH172YL63_RS17315	COG1363	Peptidase, m42
KH172YL63_RS17325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS17330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KH172YL63_RS17340	COG0510	thiamine kinase activity
KH172YL63_RS17345	COG1523	belongs to the glycosyl hydrolase 13 family
KH172YL63_RS17350	COG1597	lipid kinase activity
KH172YL63_RS17365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KH172YL63_RS17375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KH172YL63_RS17380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KH172YL63_RS17385	COG1349	DNA-binding transcription factor activity
KH172YL63_RS17390	COG1187	pseudouridine synthase activity
KH172YL63_RS17395	COG2244	polysaccharide biosynthetic process
KH172YL63_RS17400	COG2081	HI0933 family
KH172YL63_RS17410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KH172YL63_RS17415	COG0495	leucyl-tRNA aminoacylation
KH172YL63_RS17420	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS17425	COG2610	gluconate transmembrane transporter activity
KH172YL63_RS17430	COG3290	protein histidine kinase activity
KH172YL63_RS17430	COG3829	transcription factor binding
KH172YL63_RS17435	COG4297	protein containing double-stranded beta helix domain
KH172YL63_RS17440	COG2814	Major facilitator Superfamily
KH172YL63_RS17455	COG1242	4 iron, 4 sulfur cluster binding
KH172YL63_RS17460	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KH172YL63_RS17465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KH172YL63_RS17480	COG2267	carboxylic ester hydrolase activity
KH172YL63_RS17485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KH172YL63_RS17490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KH172YL63_RS17495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KH172YL63_RS17510	COG1268	BioY protein
KH172YL63_RS17525	COG1506	peptidase
KH172YL63_RS17530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KH172YL63_RS17535	COG1116	anion transmembrane transporter activity
KH172YL63_RS17540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KH172YL63_RS17555	COG4824	toxin secretion phage lysis holin
KH172YL63_RS17575	COG1854	S-ribosylhomocysteine lyase activity
KH172YL63_RS17580	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KH172YL63_RS17585	COG3443	Belongs to the bacterial solute-binding protein 9 family
KH172YL63_RS17585	COG0803	Belongs to the bacterial solute-binding protein 9 family
KH172YL63_RS17590	COG1271	oxidase subunit
KH172YL63_RS17595	COG1294	oxidase, subunit
KH172YL63_RS17600	COG0300	oxidoreductase activity
KH172YL63_RS17610	COG3620	sequence-specific DNA binding
KH172YL63_RS17615	COG4948	Mandelate Racemase Muconate Lactonizing
KH172YL63_RS17620	COG0318	PFAM AMP-dependent synthetase and ligase
KH172YL63_RS17625	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KH172YL63_RS17630	COG0596	Alpha beta hydrolase
KH172YL63_RS17635	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KH172YL63_RS17640	COG1169	isochorismate synthase
KH172YL63_RS17645	COG1575	Belongs to the MenA family. Type 1 subfamily
KH172YL63_RS17650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KH172YL63_RS17655	COG0058	SHG alpha-glucan phosphorylase activity
KH172YL63_RS17660	COG0297	glycogen (starch) synthase activity
KH172YL63_RS17665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KH172YL63_RS17800	COG1247	-acetyltransferase
KH172YL63_RS17810	COG1285	pathogenesis
KH172YL63_RS17815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KH172YL63_RS17815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KH172YL63_RS17815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KH172YL63_RS17820	COG1105	Belongs to the carbohydrate kinase PfkB family
KH172YL63_RS17825	COG1349	DNA-binding transcription factor activity
KH172YL63_RS17830	COG1368	sulfuric ester hydrolase activity
KH172YL63_RS17845	COG0561	phosphatase activity
KH172YL63_RS17850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KH172YL63_RS17860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KH172YL63_RS17865	COG0363	glucosamine-6-phosphate deaminase activity
KH172YL63_RS17870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KH172YL63_RS17880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KH172YL63_RS17880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KH172YL63_RS17900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KH172YL63_RS17905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KH172YL63_RS17920	COG1979	alcohol dehydrogenase
KH172YL63_RS17925	COG2155	Conserved Protein
KH172YL63_RS17930	COG1012	belongs to the aldehyde dehydrogenase family
KH172YL63_RS17935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KH172YL63_RS17940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KH172YL63_RS17945	COG1012	belongs to the aldehyde dehydrogenase family
KH172YL63_RS17950	COG3829	transcription factor binding
KH172YL63_RS17955	COG0753	catalase activity
KH172YL63_RS17965	COG1012	belongs to the aldehyde dehydrogenase family
KH172YL63_RS17980	COG1098	S1 RNA binding domain
KH172YL63_RS17990	COG1595	DNA-templated transcription, initiation
KH172YL63_RS18000	COG0733	neurotransmitter:sodium symporter activity
KH172YL63_RS18010	COG0436	Aminotransferase
KH172YL63_RS18015	COG1522	sequence-specific DNA binding
KH172YL63_RS18020	COG2267	carboxylic ester hydrolase activity
KH172YL63_RS18025	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KH172YL63_RS18030	COG2032	superoxide dismutase activity
KH172YL63_RS18040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KH172YL63_RS18050	COG5018	Exonuclease
KH172YL63_RS18055	COG2814	Major facilitator Superfamily
KH172YL63_RS18060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KH172YL63_RS18075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KH172YL63_RS18075	COG2111	Na H antiporter
KH172YL63_RS18080	COG2111	Na H antiporter
KH172YL63_RS18085	COG1006	Multisubunit Na H antiporter MnhC subunit
KH172YL63_RS18090	COG0651	ATP synthesis coupled electron transport
KH172YL63_RS18095	COG1863	multisubunit Na H antiporter MnhE subunit
KH172YL63_RS18100	COG2212	antiporter activity
KH172YL63_RS18110	COG4876	unkown
KH172YL63_RS18115	COG2050	protein possibly involved in aromatic compounds catabolism
KH172YL63_RS18130	COG2056	Na+-H+ antiporter family
KH172YL63_RS18135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KH172YL63_RS18140	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KH172YL63_RS18150	COG3584	3D domain protein
KH172YL63_RS18170	COG1252	NADH dehydrogenase
KH172YL63_RS18180	COG2808	Putative FMN-binding domain
KH172YL63_RS18185	COG0702	epimerase
KH172YL63_RS18190	COG0316	Belongs to the HesB IscA family
KH172YL63_RS18205	COG1252	NADH dehydrogenase
KH172YL63_RS18210	COG4837	Protein of unknown function (DUF1462)
KH172YL63_RS18215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KH172YL63_RS18220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KH172YL63_RS18225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KH172YL63_RS18230	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KH172YL63_RS18240	COG0647	UMP catabolic process
KH172YL63_RS18245	COG2445	Protein of unknown function DUF86
KH172YL63_RS18260	COG4470	Protein conserved in bacteria
KH172YL63_RS18275	COG0739	heme binding
KH172YL63_RS18285	COG0733	neurotransmitter:sodium symporter activity
KH172YL63_RS18290	COG1757	Na H antiporter
KH172YL63_RS18305	COG3377	Domain of unknown function (DUF1805)
KH172YL63_RS18310	COG0737	Belongs to the 5'-nucleotidase family
KH172YL63_RS18315	COG0730	response to heat
KH172YL63_RS18320	COG1801	Protein of unknown function DUF72
KH172YL63_RS18325	COG0719	Fe-S assembly protein
KH172YL63_RS18330	COG0822	iron-sulfur transferase activity
KH172YL63_RS18335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KH172YL63_RS18340	COG0719	Fe-S assembly protein
KH172YL63_RS18345	COG0396	ATPase activity
KH172YL63_RS18350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KH172YL63_RS18355	COG1464	Belongs to the NlpA lipoprotein family
KH172YL63_RS18360	COG2011	ABC-type metal ion transport system permease component
KH172YL63_RS18365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KH172YL63_RS18375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KH172YL63_RS18380	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KH172YL63_RS18390	COG0509	glycine decarboxylation via glycine cleavage system
KH172YL63_RS18395	COG1393	Belongs to the ArsC family
KH172YL63_RS18410	COG1960	acyl-CoA dehydrogenase activity
KH172YL63_RS18415	COG0183	Belongs to the thiolase family
KH172YL63_RS18420	COG1024	Enoyl-CoA hydratase
KH172YL63_RS18420	COG1250	3-hydroxyacyl-CoA dehydrogenase
KH172YL63_RS18430	COG2364	Membrane
KH172YL63_RS18435	COG0385	Bile acid
KH172YL63_RS18450	COG0506	proline dehydrogenase activity
KH172YL63_RS18460	COG5577	PFAM Coat F domain
KH172YL63_RS18475	COG1120	ATPase activity
KH172YL63_RS18480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KH172YL63_RS18485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KH172YL63_RS18490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KH172YL63_RS18510	COG0673	inositol 2-dehydrogenase activity
KH172YL63_RS18515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KH172YL63_RS18535	COG1785	Belongs to the alkaline phosphatase family
KH172YL63_RS18540	COG1834	amidinotransferase
KH172YL63_RS18560	COG1979	alcohol dehydrogenase
KH172YL63_RS18565	COG0583	DNA-binding transcription factor activity
KH172YL63_RS18570	COG0655	NAD(P)H dehydrogenase (quinone) activity
KH172YL63_RS18585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KH172YL63_RS18590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KH172YL63_RS18595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KH172YL63_RS18595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KH172YL63_RS18600	COG5002	protein histidine kinase activity
KH172YL63_RS18645	COG0716	FMN binding
KH172YL63_RS18650	COG2814	Major facilitator Superfamily
KH172YL63_RS18665	COG3227	Zinc metalloprotease (Elastase)
KH172YL63_RS18680	COG1113	amino acid transport
KH172YL63_RS18685	COG3403	YqcI/YcgG family
KH172YL63_RS18690	COG1280	lysine exporter protein (LysE YggA)
KH172YL63_RS18695	COG5577	PFAM Coat F domain
KH172YL63_RS18705	COG0460	homoserine dehydrogenase
KH172YL63_RS18715	COG1027	Aspartate ammonia-lyase
KH172YL63_RS18725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KH172YL63_RS18735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KH172YL63_RS18755	COG2217	Heavy metal translocating P-type atpase
KH172YL63_RS18765	COG3682	Transcriptional regulator
KH172YL63_RS18770	COG1388	LysM domain
KH172YL63_RS18775	COG5002	protein histidine kinase activity
KH172YL63_RS18780	COG0745	RESPONSE REGULATOR receiver
KH172YL63_RS18795	COG0701	Predicted permease
KH172YL63_RS18810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KH172YL63_RS18815	COG0557	exoribonuclease II activity
KH172YL63_RS18820	COG1647	Serine aminopeptidase, S33
KH172YL63_RS18825	COG3344	reverse transcriptase
KH172YL63_RS18830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KH172YL63_RS18835	COG0148	phosphopyruvate hydratase activity
KH172YL63_RS18870	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KH172YL63_RS18875	COG0840	transmembrane signaling receptor activity
KH172YL63_RS18910	COG5002	protein histidine kinase activity
KH172YL63_RS18915	COG0745	RESPONSE REGULATOR receiver
KH172YL63_RS18940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KH172YL63_RS18945	COG1481	regulation of sporulation
KH172YL63_RS18950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KH172YL63_RS18955	COG1660	Displays ATPase and GTPase activities
KH172YL63_RS18960	COG1051	belongs to the nudix hydrolase family
KH172YL63_RS18980	COG0492	ferredoxin-NADP+ reductase activity
KH172YL63_RS18985	COG0457	Tetratricopeptide repeat
KH172YL63_RS18990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KH172YL63_RS18990	COG0140	phosphoribosyl-ATP diphosphatase activity
KH172YL63_RS18995	COG0107	imidazoleglycerol-phosphate synthase activity
KH172YL63_RS19000	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KH172YL63_RS19005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KH172YL63_RS19010	COG0131	Imidazoleglycerol-phosphate dehydratase
KH172YL63_RS19015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KH172YL63_RS19020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KH172YL63_RS19025	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KH172YL63_RS19030	COG0110	maltose O-acetyltransferase activity
KH172YL63_RS19035	COG0546	phosphoglycolate phosphatase activity
KH172YL63_RS19040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KH172YL63_RS19050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KH172YL63_RS19060	COG1950	PFAM Membrane protein of
KH172YL63_RS19065	COG1983	PspC domain protein
KH172YL63_RS19070	COG3595	metallopeptidase activity
KH172YL63_RS19080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KH172YL63_RS19085	COG0556	nucleotide-excision repair
KH172YL63_RS19090	COG4897	Protein conserved in bacteria
KH172YL63_RS19100	COG0596	Alpha beta hydrolase
KH172YL63_RS19105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KH172YL63_RS19115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KH172YL63_RS19120	COG0569	domain protein
KH172YL63_RS19130	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KH172YL63_RS19150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KH172YL63_RS19165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KH172YL63_RS19170	COG0297	glycogen (starch) synthase activity
KH172YL63_RS19185	COG4464	protein tyrosine phosphatase activity
KH172YL63_RS19195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KH172YL63_RS19200	COG3409	Peptidoglycan-binding domain 1 protein
KH172YL63_RS19200	COG0793	Belongs to the peptidase S41A family
KH172YL63_RS19205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KH172YL63_RS19215	COG0626	cystathionine gamma-synthase activity
KH172YL63_RS19225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KH172YL63_RS19245	COG0739	heme binding
KH172YL63_RS19250	COG2177	Part of the ABC transporter FtsEX involved in
KH172YL63_RS19255	COG2884	Cell division ATP-binding protein ftsE
KH172YL63_RS19265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KH172YL63_RS19275	COG0653	protein targeting
KH172YL63_RS19280	COG3012	SEC-C Motif Domain Protein
KH172YL63_RS19280	COG1405	negative regulation of cell septum assembly
KH172YL63_RS19320	COG1516	flagellar protein fliS
KH172YL63_RS19325	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KH172YL63_RS19330	COG1334	flagellar protein FlaG
KH172YL63_RS19340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KH172YL63_RS19345	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
KH172YL63_RS19355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KH172YL63_RS19360	COG1256	bacterial-type flagellum assembly
KH172YL63_RS19360	COG4786	Flagellar basal body rod
KH172YL63_RS19370	COG2747	anti-sigma28 factor FlgM
KH172YL63_RS19385	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KH172YL63_RS19390	COG1307	EDD domain protein, DegV family
KH172YL63_RS19405	COG1847	R3H domain protein
KH172YL63_RS19410	COG2208	phosphoserine phosphatase activity
KH172YL63_RS19435	COG0300	oxidoreductase activity
KH172YL63_RS19455	COG5001	Diguanylate cyclase
KH172YL63_RS19455	COG3300	MHYT domain
KH172YL63_RS19475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KH172YL63_RS19495	COG0346	lactoylglutathione lyase activity
KH172YL63_RS19505	COG1227	inorganic diphosphatase activity
KH172YL63_RS19520	COG0768	penicillin binding
KH172YL63_RS19535	COG1388	LysM domain
KH172YL63_RS19535	COG0791	NLP P60 protein
KH172YL63_RS19540	COG3850	Histidine kinase
KH172YL63_RS19540	COG5002	protein histidine kinase activity
KH172YL63_RS19560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KH172YL63_RS19560	COG1263	PTS System
KH172YL63_RS19565	COG0366	Alpha amylase catalytic
KH172YL63_RS19590	COG2188	Transcriptional regulator
KH172YL63_RS19595	COG2197	response regulator
KH172YL63_RS19600	COG4585	Histidine kinase
KH172YL63_RS19605	COG1739	Uncharacterized protein family UPF0029
KH172YL63_RS19610	COG1316	TRANSCRIPTIONal
KH172YL63_RS19615	COG0438	transferase activity, transferring glycosyl groups
KH172YL63_RS19625	COG2244	polysaccharide biosynthetic process
KH172YL63_RS19630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KH172YL63_RS19635	COG1215	transferase activity, transferring glycosyl groups
KH172YL63_RS19650	COG3307	-O-antigen
KH172YL63_RS19660	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KH172YL63_RS19665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KH172YL63_RS19670	COG2385	sporulation resulting in formation of a cellular spore
KH172YL63_RS19670	COG2247	cell wall binding repeat
KH172YL63_RS19670	COG2385	sporulation resulting in formation of a cellular spore
KH172YL63_RS19670	COG2247	cell wall binding repeat
KH172YL63_RS19680	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS19690	COG1404	Belongs to the peptidase S8 family
KH172YL63_RS19700	COG2247	cell wall binding repeat
KH172YL63_RS19700	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS19705	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS19705	COG2247	cell wall binding repeat
KH172YL63_RS19710	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS19710	COG2247	cell wall binding repeat
KH172YL63_RS19725	COG2247	cell wall binding repeat
KH172YL63_RS19725	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS19740	COG0438	transferase activity, transferring glycosyl groups
KH172YL63_RS19755	COG0737	Belongs to the 5'-nucleotidase family
KH172YL63_RS19775	COG1464	Belongs to the NlpA lipoprotein family
KH172YL63_RS19780	COG2011	ABC-type metal ion transport system permease component
KH172YL63_RS19785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KH172YL63_RS19800	COG1511	domain protein
KH172YL63_RS19805	COG1309	transcriptional regulator
KH172YL63_RS19810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KH172YL63_RS19820	COG1595	DNA-templated transcription, initiation
KH172YL63_RS19825	COG3300	MHYT domain
KH172YL63_RS19825	COG5001	Diguanylate cyclase
KH172YL63_RS19830	COG3852	Histidine kinase
KH172YL63_RS19840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KH172YL63_RS19845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KH172YL63_RS19855	COG1263	PTS System
KH172YL63_RS19855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KH172YL63_RS19860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KH172YL63_RS19870	COG1404	Belongs to the peptidase S8 family
KH172YL63_RS19890	COG4974	Belongs to the 'phage' integrase family
KH172YL63_RS19920	COG2610	gluconate transmembrane transporter activity
KH172YL63_RS20140	COG1316	TRANSCRIPTIONal
KH172YL63_RS20165	COG5444	nuclease activity
KH172YL63_RS20185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KH172YL63_RS20195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KH172YL63_RS20195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KH172YL63_RS20195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KH172YL63_RS20200	COG3711	transcriptional antiterminator
KH172YL63_RS20200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KH172YL63_RS20215	COG1621	beta-fructofuranosidase activity
KH172YL63_RS20220	COG1929	Belongs to the glycerate kinase type-1 family
KH172YL63_RS20230	COG0383	alpha-mannosidase activity
KH172YL63_RS20235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KH172YL63_RS20235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KH172YL63_RS20235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KH172YL63_RS20240	COG1737	Transcriptional regulator
KH172YL63_RS20250	COG1940	carbohydrate kinase activity
KH172YL63_RS20255	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
KH172YL63_RS20265	COG1653	transport
KH172YL63_RS20270	COG1175	transmembrane transport
KH172YL63_RS20275	COG0395	ABC-type sugar transport system, permease component
KH172YL63_RS20290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KH172YL63_RS20295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KH172YL63_RS20320	COG0438	transferase activity, transferring glycosyl groups
KH172YL63_RS20350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KH172YL63_RS20355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KH172YL63_RS20360	COG4464	protein tyrosine phosphatase activity
KH172YL63_RS20365	COG0489	protein tyrosine kinase activity
KH172YL63_RS20370	COG3944	biosynthesis protein
KH172YL63_RS20380	COG0791	NLP P60 protein
KH172YL63_RS20380	COG1388	LysM domain
KH172YL63_RS20385	COG1316	TRANSCRIPTIONal
KH172YL63_RS20410	COG0010	Belongs to the arginase family
KH172YL63_RS20415	COG1228	amidohydrolase
KH172YL63_RS20420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KH172YL63_RS20425	COG2986	histidine ammonia-lyase
KH172YL63_RS20440	COG1943	Transposase
KH172YL63_RS20465	COG1785	Belongs to the alkaline phosphatase family
KH172YL63_RS20470	COG4715	Zinc finger, swim domain protein
KH172YL63_RS20475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KH172YL63_RS20485	COG0629	single-stranded DNA binding
KH172YL63_RS20495	COG1396	sequence-specific DNA binding
KH172YL63_RS20520	COG4786	Flagellar basal body rod
KH172YL63_RS20525	COG4786	Flagellar basal body rod
KH172YL63_RS20530	COG1077	Cell shape determining protein MreB Mrl
KH172YL63_RS20535	COG1609	Transcriptional regulator
KH172YL63_RS20540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KH172YL63_RS20555	COG0739	heme binding
KH172YL63_RS20565	COG2385	sporulation resulting in formation of a cellular spore
KH172YL63_RS20580	COG4836	Membrane
KH172YL63_RS20600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KH172YL63_RS20605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KH172YL63_RS20610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KH172YL63_RS20615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KH172YL63_RS20620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KH172YL63_RS20625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KH172YL63_RS20630	COG0356	it plays a direct role in the translocation of protons across the membrane
KH172YL63_RS20645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KH172YL63_RS20650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KH172YL63_RS20660	COG0698	ribose 5-phosphate isomerase
KH172YL63_RS20665	COG0840	transmembrane signaling receptor activity
KH172YL63_RS20675	COG1971	Probably functions as a manganese efflux pump
KH172YL63_RS20680	COG0009	L-threonylcarbamoyladenylate synthase
KH172YL63_RS20700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KH172YL63_RS20710	COG1435	thymidine kinase activity
KH172YL63_RS20720	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KH172YL63_RS20725	COG1494	fructose-1,6-bisphosphatase
KH172YL63_RS20730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KH172YL63_RS20740	COG0191	fructose-bisphosphate aldolase activity
KH172YL63_RS20745	COG2204	response regulator
KH172YL63_RS20750	COG4821	SIS domain
KH172YL63_RS20755	COG0504	CTP synthase activity
KH172YL63_RS20770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KH172YL63_RS20770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KH172YL63_RS20770	COG1703	isobutyryl-CoA mutase activity
KH172YL63_RS20780	COG1960	acyl-CoA dehydrogenase activity
KH172YL63_RS20785	COG1960	acyl-CoA dehydrogenase activity
KH172YL63_RS20790	COG1250	3-hydroxyacyl-CoA dehydrogenase
KH172YL63_RS20795	COG0183	Belongs to the thiolase family
KH172YL63_RS20800	COG2181	nitrate reductase activity
KH172YL63_RS20800	COG0247	lactate metabolic process
KH172YL63_RS20805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KH172YL63_RS20810	COG4294	response to UV
KH172YL63_RS20825	COG0018	arginyl-trna synthetase
KH172YL63_RS20830	COG4506	Protein conserved in bacteria
KH172YL63_RS20835	COG0010	Belongs to the arginase family
KH172YL63_RS20840	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KH172YL63_RS20845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KH172YL63_RS20855	COG1994	Peptidase M50
KH172YL63_RS20870	COG3465	dGTPase activity
KH172YL63_RS20875	COG1078	dGTPase activity
KH172YL63_RS20895	COG0280	phosphate acetyltransferase
KH172YL63_RS20905	COG3773	Cell wall hydrolase
KH172YL63_RS20915	COG2363	Small membrane protein
KH172YL63_RS20930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KH172YL63_RS20945	COG0351	phosphomethylpyrimidine kinase
KH172YL63_RS20950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KH172YL63_RS20960	COG1131	(ABC) transporter
KH172YL63_RS20985	COG1191	sigma factor activity
KH172YL63_RS21000	COG0860	N-Acetylmuramoyl-L-alanine amidase
KH172YL63_RS21020	COG0561	phosphatase activity
KH172YL63_RS21030	COG2031	fatty acid transporter
KH172YL63_RS21045	COG4191	Histidine kinase
KH172YL63_RS21070	COG1620	l-lactate permease
KH172YL63_RS21080	COG2318	DinB family
KH172YL63_RS21085	COG2364	Membrane
KH172YL63_RS21095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KH172YL63_RS21100	COG0723	plastoquinol--plastocyanin reductase activity
KH172YL63_RS21100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KH172YL63_RS21110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KH172YL63_RS21110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KH172YL63_RS21140	COG3835	regulator
KH172YL63_RS21145	COG1929	Belongs to the glycerate kinase type-1 family
KH172YL63_RS21150	COG2610	gluconate transmembrane transporter activity
KH172YL63_RS21165	COG1028	Short-chain dehydrogenase reductase Sdr
KH172YL63_RS21170	COG2610	gluconate transmembrane transporter activity
KH172YL63_RS21175	COG0583	DNA-binding transcription factor activity
KH172YL63_RS21185	COG1511	domain protein
KH172YL63_RS21190	COG1674	ftsk spoiiie
KH172YL63_RS21190	COG0433	COG0433 Predicted ATPase
KH172YL63_RS21195	COG4499	WXG100 protein secretion system (Wss), protein YukC
KH172YL63_RS21200	COG5417	Belongs to the EsaB family
KH172YL63_RS21205	COG4842	Belongs to the WXG100 family
KH172YL63_RS21215	COG0745	RESPONSE REGULATOR receiver
KH172YL63_RS21220	COG0642	Histidine kinase
KH172YL63_RS21225	COG1136	(ABC) transporter
KH172YL63_RS21230	COG0577	efflux transmembrane transporter activity
KH172YL63_RS21285	COG2814	Major facilitator Superfamily
KH172YL63_RS21290	COG4682	membrane
KH172YL63_RS21295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KH172YL63_RS21300	COG1064	alcohol dehydrogenase
KH172YL63_RS21305	COG3300	MHYT domain
KH172YL63_RS21305	COG5001	Diguanylate cyclase
KH172YL63_RS21330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KH172YL63_RS21335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KH172YL63_RS21340	COG4853	Protein conserved in bacteria
KH172YL63_RS21345	COG4863	YycH protein
KH172YL63_RS21350	COG5002	protein histidine kinase activity
KH172YL63_RS21355	COG0745	RESPONSE REGULATOR receiver
KH172YL63_RS21360	COG0739	heme binding
KH172YL63_RS21395	COG0754	glutathionylspermidine amidase activity
KH172YL63_RS21410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KH172YL63_RS21415	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KH172YL63_RS21420	COG1132	(ABC) transporter
KH172YL63_RS21425	COG0305	Participates in initiation and elongation during chromosome replication
KH172YL63_RS21430	COG0359	binds to the 23S rRNA
KH172YL63_RS21435	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KH172YL63_RS21440	COG4241	membrane
KH172YL63_RS21445	COG0840	transmembrane signaling receptor activity
KH172YL63_RS21450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KH172YL63_RS21460	COG0360	Binds together with S18 to 16S ribosomal RNA
KH172YL63_RS21465	COG0012	GTP binding
KH172YL63_RS21470	COG4481	Protein conserved in bacteria
KH172YL63_RS21475	COG0668	transmembrane transport
KH172YL63_RS21490	COG1475	DNA binding
KH172YL63_RS21495	COG1192	Involved in chromosome partitioning
KH172YL63_RS21500	COG1475	DNA binding
KH172YL63_RS21505	COG0357	Ribosomal RNA small subunit methyltransferase G
KH172YL63_RS21510	COG0445	tRNA wobble uridine modification
KH172YL63_RS21515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KH172YL63_RS21520	COG1847	R3H domain protein
KH172YL63_RS21530	COG0594	ribonuclease P activity
KH172YL63_RS21535	COG0230	Belongs to the bacterial ribosomal protein bL34 family