locus-tag	class	description
KXZ66_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KXZ66_RS00010	COG0592	DNA-directed DNA polymerase activity
KXZ66_RS00015	COG2501	S4 domain
KXZ66_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KXZ66_RS00030	COG0187	DNA topoisomerase II activity
KXZ66_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KXZ66_RS00070	COG0516	GMP reductase activity
KXZ66_RS00070	COG0517	IMP dehydrogenase activity
KXZ66_RS00075	COG1686	Belongs to the peptidase S11 family
KXZ66_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KXZ66_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KXZ66_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KXZ66_RS00100	COG1428	Deoxynucleoside kinase
KXZ66_RS00105	COG1428	Deoxynucleoside kinase
KXZ66_RS00110	COG1388	LysM domain
KXZ66_RS00110	COG3858	chitin binding
KXZ66_RS00115	COG1335	isochorismatase
KXZ66_RS00120	COG0590	tRNA wobble adenosine to inosine editing
KXZ66_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KXZ66_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KXZ66_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KXZ66_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
KXZ66_RS00190	COG3853	Toxic anion resistance protein (TelA)
KXZ66_RS00195	COG1982	Orn Lys Arg decarboxylase major
KXZ66_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KXZ66_RS00205	COG3870	Protein conserved in bacteria
KXZ66_RS00210	COG1728	Protein conserved in bacteria
KXZ66_RS00215	COG0470	DNA polymerase III
KXZ66_RS00220	COG1774	PSP1 C-terminal conserved region
KXZ66_RS00225	COG4467	Involved in initiation control of chromosome replication
KXZ66_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KXZ66_RS00235	COG2827	Endonuclease containing a URI domain
KXZ66_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KXZ66_RS00245	COG2002	toxin-antitoxin pair type II binding
KXZ66_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KXZ66_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KXZ66_RS00255	COG0084	hydrolase, TatD family'
KXZ66_RS00260	COG3583	domain protein
KXZ66_RS00260	COG3584	3D domain protein
KXZ66_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KXZ66_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KXZ66_RS00280	COG4466	Protein conserved in bacteria
KXZ66_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KXZ66_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KXZ66_RS00300	COG0251	oxidation-reduction process
KXZ66_RS00305	COG2088	sporulation resulting in formation of a cellular spore
KXZ66_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KXZ66_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KXZ66_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KXZ66_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
KXZ66_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KXZ66_RS00340	COG2002	toxin-antitoxin pair type II binding
KXZ66_RS00345	COG2244	polysaccharide biosynthetic process
KXZ66_RS00350	COG3956	TIGRFAM MazG family protein
KXZ66_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KXZ66_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KXZ66_RS00375	COG1098	S1 RNA binding domain
KXZ66_RS00390	COG2208	phosphoserine phosphatase activity
KXZ66_RS00395	COG2304	oxidoreductase activity
KXZ66_RS00400	COG0515	serine threonine protein kinase
KXZ66_RS00405	COG0037	tRNA processing
KXZ66_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KXZ66_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KXZ66_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KXZ66_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KXZ66_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KXZ66_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KXZ66_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KXZ66_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
KXZ66_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KXZ66_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KXZ66_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KXZ66_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KXZ66_RS00470	COG1396	sequence-specific DNA binding
KXZ66_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KXZ66_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KXZ66_RS00560	COG4463	regulation of RNA biosynthetic process
KXZ66_RS00565	COG3880	PFAM UvrB UvrC protein
KXZ66_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KXZ66_RS00575	COG0542	response to heat
KXZ66_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KXZ66_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KXZ66_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
KXZ66_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KXZ66_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KXZ66_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KXZ66_RS00610	COG1045	serine acetyltransferase
KXZ66_RS00615	COG0215	cysteine-tRNA ligase activity
KXZ66_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KXZ66_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KXZ66_RS00630	COG3688	RNA-binding protein containing a PIN domain
KXZ66_RS00635	COG1595	DNA-templated transcription, initiation
KXZ66_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KXZ66_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
KXZ66_RS00660	COG0081	regulation of translation
KXZ66_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KXZ66_RS00675	COG2813	Specifically methylates the guanine in position
KXZ66_RS00680	COG0085	RNA polymerase activity
KXZ66_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KXZ66_RS00690	COG1358	cellular component organization or biogenesis
KXZ66_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KXZ66_RS00700	COG0049	tRNA binding
KXZ66_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KXZ66_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KXZ66_RS00715	COG0596	Alpha beta hydrolase
KXZ66_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KXZ66_RS00730	COG0088	Forms part of the polypeptide exit tunnel
KXZ66_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KXZ66_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KXZ66_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KXZ66_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KXZ66_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KXZ66_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KXZ66_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KXZ66_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KXZ66_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KXZ66_RS00820	COG0200	Binds to the 23S rRNA
KXZ66_RS00825	COG0201	protein transport
KXZ66_RS00830	COG0563	adenylate kinase activity
KXZ66_RS00835	COG0024	Methionine aminopeptidase
KXZ66_RS00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
KXZ66_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KXZ66_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KXZ66_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KXZ66_RS00865	COG0202	RNA polymerase activity
KXZ66_RS00870	COG0203	ribosomal protein L17
KXZ66_RS00875	COG1122	ATPase activity
KXZ66_RS00880	COG1122	ATPase activity
KXZ66_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KXZ66_RS00890	COG0101	tRNA pseudouridine synthase activity
KXZ66_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KXZ66_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KXZ66_RS00905	COG2226	methyltransferase
KXZ66_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS00920	COG0489	protein tyrosine kinase activity
KXZ66_RS00930	COG2194	sulfuric ester hydrolase activity
KXZ66_RS00935	COG0726	polysaccharide deacetylase
KXZ66_RS01015	COG0659	secondary active sulfate transmembrane transporter activity
KXZ66_RS01020	COG0385	Bile acid
KXZ66_RS01025	COG2819	hydrolase of the alpha beta superfamily
KXZ66_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KXZ66_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KXZ66_RS01045	COG2207	Transcriptional regulator
KXZ66_RS01050	COG3876	Protein conserved in bacteria
KXZ66_RS01055	COG1472	Belongs to the glycosyl hydrolase 3 family
KXZ66_RS01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KXZ66_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS01065	COG1263	PTS System
KXZ66_RS01070	COG1737	Transcriptional regulator
KXZ66_RS01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KXZ66_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KXZ66_RS01085	COG1683	Conserved Protein
KXZ66_RS01115	COG1595	DNA-templated transcription, initiation
KXZ66_RS01120	COG5662	AntiSigma factor
KXZ66_RS01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KXZ66_RS01130	COG4856	YbbR-like protein
KXZ66_RS01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KXZ66_RS01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KXZ66_RS01150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KXZ66_RS01155	COG3002	Belongs to the UPF0753 family
KXZ66_RS01160	COG0288	reversible hydration of carbon dioxide
KXZ66_RS01170	COG5609	conserved protein (DUF2294)
KXZ66_RS01175	COG0640	Transcriptional regulator
KXZ66_RS01180	COG2814	Major facilitator Superfamily
KXZ66_RS01195	COG0515	serine threonine protein kinase
KXZ66_RS01210	COG1113	amino acid transport
KXZ66_RS01225	COG2602	Beta-lactamase
KXZ66_RS01230	COG2124	cytochrome p450
KXZ66_RS01240	COG0531	amino acid
KXZ66_RS01245	COG0584	glycerophosphoryl diester phosphodiesterase
KXZ66_RS01250	COG2271	Major facilitator Superfamily
KXZ66_RS01260	COG1846	Transcriptional regulator
KXZ66_RS01260	COG0456	acetyltransferase
KXZ66_RS01265	COG2271	Major facilitator Superfamily
KXZ66_RS01275	COG3409	Peptidoglycan-binding domain 1 protein
KXZ66_RS01280	COG0697	spore germination
KXZ66_RS01285	COG1917	Cupin 2, conserved barrel domain protein
KXZ66_RS01285	COG2207	Transcriptional regulator
KXZ66_RS01290	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KXZ66_RS01295	COG3591	Belongs to the peptidase S1B family
KXZ66_RS01305	COG0596	Alpha beta hydrolase
KXZ66_RS01310	COG1183	phosphatidylcholine synthase activity
KXZ66_RS01315	COG0586	Pfam SNARE associated Golgi protein
KXZ66_RS01320	COG0688	phosphatidylethanolamine metabolic process
KXZ66_RS01330	COG2312	Erythromycin esterase
KXZ66_RS01335	COG1054	Belongs to the UPF0176 family
KXZ66_RS01340	COG1301	dicarboxylic acid transport
KXZ66_RS01345	COG1263	PTS System
KXZ66_RS01345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS01345	COG2190	(PTS) system
KXZ66_RS01350	COG0363	glucosamine-6-phosphate deaminase activity
KXZ66_RS01355	COG2188	Transcriptional regulator
KXZ66_RS01365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KXZ66_RS01370	COG0833	amino acid
KXZ66_RS01375	COG2040	homocysteine
KXZ66_RS01380	COG1115	amino acid carrier protein
KXZ66_RS01385	COG2066	Belongs to the glutaminase family
KXZ66_RS01390	COG4191	Histidine kinase
KXZ66_RS01395	COG0784	Response regulator, receiver
KXZ66_RS01400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KXZ66_RS01405	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS01410	COG2271	Major facilitator Superfamily
KXZ66_RS01415	COG4948	Mandelate Racemase Muconate Lactonizing
KXZ66_RS01420	COG2186	Transcriptional regulator
KXZ66_RS01425	COG2721	sulfolactate sulfo-lyase activity
KXZ66_RS01430	COG3173	Aminoglycoside phosphotransferase
KXZ66_RS01440	COG0697	spore germination
KXZ66_RS01445	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS01450	COG2205	protein histidine kinase activity
KXZ66_RS01455	COG1131	(ABC) transporter
KXZ66_RS01475	COG3773	Cell wall hydrolase
KXZ66_RS01480	COG2304	oxidoreductase activity
KXZ66_RS01490	COG3540	Alkaline phosphatase
KXZ66_RS01495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KXZ66_RS01500	COG0805	protein transport
KXZ66_RS01505	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KXZ66_RS01510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KXZ66_RS01515	COG0477	Major facilitator Superfamily
KXZ66_RS01520	COG1309	transcriptional regulator
KXZ66_RS01525	COG0252	asparaginase activity
KXZ66_RS01530	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KXZ66_RS01535	COG1714	RDD family
KXZ66_RS01540	COG3012	SEC-C Motif Domain Protein
KXZ66_RS01540	COG1405	negative regulation of cell septum assembly
KXZ66_RS01545	COG3290	protein histidine kinase activity
KXZ66_RS01550	COG3279	Response regulator of the LytR AlgR family
KXZ66_RS01555	COG4555	ABC transporter
KXZ66_RS01560	COG1668	transmembrane transport
KXZ66_RS01565	COG0667	Aldo Keto reductase
KXZ66_RS01580	COG1595	DNA-templated transcription, initiation
KXZ66_RS01585	COG1595	DNA-templated transcription, initiation
KXZ66_RS01590	COG1876	peptidase activity
KXZ66_RS01595	COG0457	Tetratricopeptide repeat
KXZ66_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS01605	COG0366	Alpha amylase catalytic
KXZ66_RS01610	COG0803	Belongs to the bacterial solute-binding protein 9 family
KXZ66_RS01615	COG1121	(ABC) transporter
KXZ66_RS01620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KXZ66_RS01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KXZ66_RS01630	COG2310	stress, protein
KXZ66_RS01635	COG2310	stress, protein
KXZ66_RS01640	COG2310	stress, protein
KXZ66_RS01645	COG0861	Integral membrane protein TerC family
KXZ66_RS01655	COG3853	Toxic anion resistance protein (TelA)
KXZ66_RS01660	COG0477	Major facilitator Superfamily
KXZ66_RS01665	COG2814	Major facilitator Superfamily
KXZ66_RS01670	COG0640	Transcriptional regulator
KXZ66_RS01675	COG4175	Glycine betaine
KXZ66_RS01675	COG0517	IMP dehydrogenase activity
KXZ66_RS01680	COG4176	ABC-type proline glycine betaine transport system permease component
KXZ66_RS01685	COG2113	Glycine betaine
KXZ66_RS01690	COG1473	amidohydrolase
KXZ66_RS01695	COG1288	antiporter activity
KXZ66_RS01705	COG0366	Alpha amylase catalytic
KXZ66_RS01710	COG0039	L-malate dehydrogenase activity
KXZ66_RS01715	COG1620	l-lactate permease
KXZ66_RS01720	COG2814	Major facilitator Superfamily
KXZ66_RS01725	COG1846	Transcriptional regulator
KXZ66_RS01730	COG1280	lysine exporter protein (LysE YggA)
KXZ66_RS01735	COG3403	YqcI/YcgG family
KXZ66_RS01740	COG1113	amino acid transport
KXZ66_RS01745	COG3665	Urea carboxylase-associated protein
KXZ66_RS01750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KXZ66_RS01755	COG1660	Displays ATPase and GTPase activities
KXZ66_RS01760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KXZ66_RS01765	COG2226	methyltransferase
KXZ66_RS01770	COG0583	DNA-binding transcription factor activity
KXZ66_RS01775	COG3458	cephalosporin-C deacetylase activity
KXZ66_RS01780	COG3541	Predicted nucleotidyltransferase
KXZ66_RS01785	COG0506	proline dehydrogenase activity
KXZ66_RS01790	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS01795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KXZ66_RS01800	COG2508	Transcriptional regulator
KXZ66_RS01805	COG3689	TIGRFAM TIGR03943 family protein
KXZ66_RS01810	COG0701	Predicted permease
KXZ66_RS01815	COG2267	carboxylic ester hydrolase activity
KXZ66_RS01820	COG0492	ferredoxin-NADP+ reductase activity
KXZ66_RS01825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KXZ66_RS01825	COG1587	Uroporphyrinogen-III synthase
KXZ66_RS01830	COG2146	nitrite reductase [NAD(P)H] activity
KXZ66_RS01835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KXZ66_RS01840	COG0243	molybdopterin cofactor binding
KXZ66_RS01845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KXZ66_RS01850	COG2223	nitrite transmembrane transporter activity
KXZ66_RS01855	COG1469	GTP cyclohydrolase I activity
KXZ66_RS01870	COG0523	cobalamin synthesis protein
KXZ66_RS01875	COG0765	amino acid transport
KXZ66_RS01880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KXZ66_RS01890	COG1714	RDD family
KXZ66_RS01900	COG1846	Transcriptional regulator
KXZ66_RS01910	COG3842	ATPase activity
KXZ66_RS01915	COG2723	6-phospho-beta-galactosidase activity
KXZ66_RS01925	COG3209	COG3209 Rhs family protein
KXZ66_RS01930	COG0840	transmembrane signaling receptor activity
KXZ66_RS01930	COG3290	protein histidine kinase activity
KXZ66_RS01935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KXZ66_RS01940	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KXZ66_RS01945	COG1733	regulation of RNA biosynthetic process
KXZ66_RS01950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS01960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS01965	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KXZ66_RS01980	COG0697	spore germination
KXZ66_RS01985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KXZ66_RS01995	COG2364	Membrane
KXZ66_RS02000	COG1126	abc transporter atp-binding protein
KXZ66_RS02005	COG0765	amino acid transport
KXZ66_RS02010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KXZ66_RS02015	COG0583	DNA-binding transcription factor activity
KXZ66_RS02020	COG0163	prenyltransferase activity
KXZ66_RS02025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KXZ66_RS02040	COG0596	Alpha beta hydrolase
KXZ66_RS02045	COG3104	oligopeptide transport
KXZ66_RS02050	COG5434	Belongs to the glycosyl hydrolase 28 family
KXZ66_RS02060	COG0697	spore germination
KXZ66_RS02070	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KXZ66_RS02075	COG1136	(ABC) transporter
KXZ66_RS02080	COG0577	efflux transmembrane transporter activity
KXZ66_RS02085	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS02090	COG5002	protein histidine kinase activity
KXZ66_RS02090	COG3850	Histidine kinase
KXZ66_RS02095	COG0457	Tetratricopeptide repeat
KXZ66_RS02115	COG0527	aspartate kinase activity
KXZ66_RS02120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS02125	COG4605	iron ion homeostasis
KXZ66_RS02130	COG4604	ABC transporter, ATP-binding protein
KXZ66_RS02135	COG4607	ABC-type enterochelin transport system periplasmic component
KXZ66_RS02140	COG2814	Major facilitator Superfamily
KXZ66_RS02145	COG1309	transcriptional regulator
KXZ66_RS02150	COG0778	Nitroreductase
KXZ66_RS02155	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KXZ66_RS02160	COG0640	Transcriptional regulator
KXZ66_RS02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KXZ66_RS02170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KXZ66_RS02175	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS02180	COG4975	Glucose uptake
KXZ66_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS02190	COG4549	nuclear export factor GLE1
KXZ66_RS02195	COG2372	response to copper ion
KXZ66_RS02195	COG1276	copper resistance
KXZ66_RS02200	COG1349	DNA-binding transcription factor activity
KXZ66_RS02210	COG2213	PTS system mannitol-specific
KXZ66_RS02215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KXZ66_RS02220	COG0246	Mannitol dehydrogenase
KXZ66_RS02225	COG0473	3-isopropylmalate dehydrogenase activity
KXZ66_RS02230	COG0681	Belongs to the peptidase S26 family
KXZ66_RS02235	COG0412	Dienelactone hydrolase
KXZ66_RS02240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KXZ66_RS02250	COG0561	phosphatase activity
KXZ66_RS02255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KXZ66_RS02260	COG1914	H( )-stimulated, divalent metal cation uptake system
KXZ66_RS02265	COG4336	lyase activity
KXZ66_RS02270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KXZ66_RS02275	COG1984	allophanate hydrolase subunit 2
KXZ66_RS02280	COG1414	Transcriptional regulator
KXZ66_RS02285	COG2755	lipolytic protein G-D-S-L family
KXZ66_RS02295	COG2329	Antibiotic biosynthesis monooxygenase
KXZ66_RS02300	COG0768	penicillin binding
KXZ66_RS02305	COG4989	oxidoreductase activity
KXZ66_RS02310	COG3711	transcriptional antiterminator
KXZ66_RS02315	COG0318	PFAM AMP-dependent synthetase and ligase
KXZ66_RS02320	COG2226	methyltransferase
KXZ66_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS02330	COG1917	Cupin 2, conserved barrel domain protein
KXZ66_RS02335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KXZ66_RS02340	COG3871	stress protein (general stress protein 26)
KXZ66_RS02350	COG2814	Major facilitator Superfamily
KXZ66_RS02355	COG1522	sequence-specific DNA binding
KXZ66_RS02360	COG0551	DNA topoisomerase type I activity
KXZ66_RS02360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KXZ66_RS02365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KXZ66_RS02370	COG3706	GGDEF domain
KXZ66_RS02375	COG5298	Protein conserved in bacteria
KXZ66_RS02380	COG1215	transferase activity, transferring glycosyl groups
KXZ66_RS02390	COG0531	amino acid
KXZ66_RS02395	COG0494	nUDIX hydrolase
KXZ66_RS02400	COG0028	Belongs to the TPP enzyme family
KXZ66_RS02415	COG1914	H( )-stimulated, divalent metal cation uptake system
KXZ66_RS02420	COG2261	transglycosylase associated protein
KXZ66_RS02425	COG4876	unkown
KXZ66_RS02430	COG2217	Heavy metal translocating P-type atpase
KXZ66_RS02435	COG3729	General stress protein
KXZ66_RS02440	COG0662	Cupin 2, conserved barrel domain protein
KXZ66_RS02445	COG2329	Antibiotic biosynthesis monooxygenase
KXZ66_RS02450	COG3546	catalase activity
KXZ66_RS02455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KXZ66_RS02460	COG3290	protein histidine kinase activity
KXZ66_RS02465	COG4565	transcriptional regulatory protein
KXZ66_RS02470	COG1301	dicarboxylic acid transport
KXZ66_RS02475	COG0628	permease
KXZ66_RS02480	COG1131	(ABC) transporter
KXZ66_RS02485	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KXZ66_RS02495	COG1960	acyl-CoA dehydrogenase activity
KXZ66_RS02510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KXZ66_RS02515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS02520	COG1181	Belongs to the D-alanine--D-alanine ligase family
KXZ66_RS02525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KXZ66_RS02530	COG0513	Belongs to the DEAD box helicase family
KXZ66_RS02535	COG3402	PFAM membrane-flanked domain
KXZ66_RS02540	COG3428	Bacterial PH domain
KXZ66_RS02545	COG0705	Rhomboid family
KXZ66_RS02550	COG0736	holo-[acyl-carrier-protein] synthase activity
KXZ66_RS02555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KXZ66_RS02560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KXZ66_RS02565	COG0864	Transcriptional regulator
KXZ66_RS02570	COG2337	Toxic component of a toxin-antitoxin (TA) module
KXZ66_RS02575	COG1366	Belongs to the anti-sigma-factor antagonist family
KXZ66_RS02580	COG1366	Belongs to the anti-sigma-factor antagonist family
KXZ66_RS02585	COG2172	sigma factor antagonist activity
KXZ66_RS02590	COG2208	phosphoserine phosphatase activity
KXZ66_RS02595	COG1366	Belongs to the anti-sigma-factor antagonist family
KXZ66_RS02600	COG2172	sigma factor antagonist activity
KXZ66_RS02605	COG1191	sigma factor activity
KXZ66_RS02610	COG2208	phosphoserine phosphatase activity
KXZ66_RS02625	COG1673	EVE domain
KXZ66_RS02630	COG1846	Transcriptional regulator
KXZ66_RS02635	COG2183	response to ionizing radiation
KXZ66_RS02645	COG3091	SprT-like family
KXZ66_RS02685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KXZ66_RS02705	COG3239	Fatty acid desaturase
KXZ66_RS02710	COG1278	Cold shock
KXZ66_RS02715	COG1329	Transcriptional regulator
KXZ66_RS02725	COG1917	Cupin 2, conserved barrel domain protein
KXZ66_RS02725	COG2207	Transcriptional regulator
KXZ66_RS02730	COG0697	spore germination
KXZ66_RS02735	COG2207	Transcriptional regulator
KXZ66_RS02735	COG3708	Transcriptional regulator
KXZ66_RS02740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KXZ66_RS02745	COG0477	Major facilitator Superfamily
KXZ66_RS02755	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
KXZ66_RS02765	COG0697	spore germination
KXZ66_RS02770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KXZ66_RS02775	COG2030	dehydratase
KXZ66_RS02780	COG3545	Serine hydrolase
KXZ66_RS02785	COG1733	regulation of RNA biosynthetic process
KXZ66_RS02790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KXZ66_RS02795	COG0640	Transcriptional regulator
KXZ66_RS02800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KXZ66_RS02810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KXZ66_RS02815	COG1316	TRANSCRIPTIONal
KXZ66_RS02830	COG5002	protein histidine kinase activity
KXZ66_RS02835	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS02840	COG0697	spore germination
KXZ66_RS02845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KXZ66_RS02850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KXZ66_RS02855	COG0640	Transcriptional regulator
KXZ66_RS02860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KXZ66_RS02875	COG4585	Histidine kinase
KXZ66_RS02880	COG2197	response regulator
KXZ66_RS02885	COG2409	Drug exporters of the RND superfamily
KXZ66_RS02890	COG1811	Na channel or pump
KXZ66_RS02895	COG4978	Transcriptional regulator
KXZ66_RS02895	COG0789	Transcriptional regulator
KXZ66_RS02900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KXZ66_RS02905	COG0778	Nitroreductase
KXZ66_RS02910	COG0346	lactoylglutathione lyase activity
KXZ66_RS02915	COG2259	Doxx family
KXZ66_RS02920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS02950	COG0071	Belongs to the small heat shock protein (HSP20) family
KXZ66_RS02965	COG1309	transcriptional regulator
KXZ66_RS02975	COG0456	acetyltransferase
KXZ66_RS02980	COG0488	(ABC) transporter
KXZ66_RS02985	COG1113	amino acid transport
KXZ66_RS02990	COG2318	DinB family
KXZ66_RS02995	COG1846	Transcriptional regulator
KXZ66_RS03000	COG2409	Drug exporters of the RND superfamily
KXZ66_RS03000	COG1033	growth of symbiont in host cell
KXZ66_RS03005	COG0778	Nitroreductase
KXZ66_RS03010	COG1846	Transcriptional regulator
KXZ66_RS03015	COG2814	Major facilitator Superfamily
KXZ66_RS03020	COG0730	response to heat
KXZ66_RS03025	COG1802	Transcriptional regulator
KXZ66_RS03030	COG3858	chitin binding
KXZ66_RS03030	COG1388	LysM domain
KXZ66_RS03045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KXZ66_RS03085	COG1785	Belongs to the alkaline phosphatase family
KXZ66_RS03090	COG5646	InterPro IPR014922
KXZ66_RS03100	COG0454	-acetyltransferase
KXZ66_RS03105	COG1078	dGTPase activity
KXZ66_RS03115	COG2814	Major facilitator Superfamily
KXZ66_RS03120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KXZ66_RS03125	COG1447	Phosphotransferase system cellobiose-specific component IIA
KXZ66_RS03130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KXZ66_RS03135	COG2723	6-phospho-beta-galactosidase activity
KXZ66_RS03140	COG2188	Transcriptional regulator
KXZ66_RS03145	COG1940	carbohydrate kinase activity
KXZ66_RS03150	COG1482	cell wall glycoprotein biosynthetic process
KXZ66_RS03155	COG4124	Belongs to the glycosyl hydrolase 26 family
KXZ66_RS03200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KXZ66_RS03205	COG0802	atpase or kinase
KXZ66_RS03210	COG1214	PFAM Peptidase M22, glycoprotease
KXZ66_RS03215	COG0456	acetyltransferase
KXZ66_RS03220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KXZ66_RS03225	COG0488	(ABC) transporter
KXZ66_RS03230	COG0315	cyclic pyranopterin monophosphate synthase activity
KXZ66_RS03235	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KXZ66_RS03240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KXZ66_RS03245	COG0805	protein transport
KXZ66_RS03255	COG1266	CAAX protease self-immunity
KXZ66_RS03265	COG0459	protein refolding
KXZ66_RS03275	COG0457	Tetratricopeptide repeat
KXZ66_RS03280	COG1063	alcohol dehydrogenase
KXZ66_RS03285	COG2211	Major facilitator Superfamily
KXZ66_RS03290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KXZ66_RS03295	COG1842	Phage shock protein A
KXZ66_RS03300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KXZ66_RS03305	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KXZ66_RS03310	COG4260	virion core protein, lumpy skin disease virus
KXZ66_RS03320	COG2814	Major facilitator Superfamily
KXZ66_RS03325	COG1063	alcohol dehydrogenase
KXZ66_RS03330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KXZ66_RS03335	COG0823	Involved in the tonB-independent uptake of proteins
KXZ66_RS03350	COG2267	carboxylic ester hydrolase activity
KXZ66_RS03360	COG2132	Multicopper oxidase
KXZ66_RS03365	COG1113	amino acid transport
KXZ66_RS03375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KXZ66_RS03380	COG0714	Associated with various cellular activities
KXZ66_RS03385	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KXZ66_RS03390	COG1305	Transglutaminase-like
KXZ66_RS03395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KXZ66_RS03395	COG0519	Catalyzes the synthesis of GMP from XMP
KXZ66_RS03410	COG2252	PERMEase
KXZ66_RS03415	COG3064	Membrane
KXZ66_RS03425	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KXZ66_RS03435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KXZ66_RS03440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KXZ66_RS03445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KXZ66_RS03450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KXZ66_RS03455	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KXZ66_RS03460	COG0047	phosphoribosylformylglycinamidine synthase activity
KXZ66_RS03465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KXZ66_RS03470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KXZ66_RS03475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KXZ66_RS03480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KXZ66_RS03485	COG0138	bifunctional purine biosynthesis protein purh
KXZ66_RS03490	COG0151	Belongs to the GarS family
KXZ66_RS03495	COG1522	sequence-specific DNA binding
KXZ66_RS03500	COG0531	amino acid
KXZ66_RS03510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KXZ66_RS03520	COG4496	protein, YerC YecD
KXZ66_RS03525	COG0069	glutamate synthase activity
KXZ66_RS03530	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KXZ66_RS03535	COG0210	DNA helicase
KXZ66_RS03540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KXZ66_RS03545	COG4851	CamS sex pheromone cAM373 precursor
KXZ66_RS03550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KXZ66_RS03555	COG1285	pathogenesis
KXZ66_RS03560	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KXZ66_RS03565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KXZ66_RS03570	COG0154	amidase activity
KXZ66_RS03575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KXZ66_RS03585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KXZ66_RS03590	COG1597	lipid kinase activity
KXZ66_RS03595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KXZ66_RS03640	COG0457	Tetratricopeptide repeat
KXZ66_RS03655	COG5444	nuclease activity
KXZ66_RS03660	COG3391	amine dehydrogenase activity
KXZ66_RS03665	COG0457	Tetratricopeptide repeat
KXZ66_RS03675	COG0217	transcriptional regulatory protein
KXZ66_RS03685	COG1309	transcriptional regulator
KXZ66_RS03690	COG3631	Ketosteroid isomerase-related protein
KXZ66_RS03710	COG3546	catalase activity
KXZ66_RS03715	COG0454	-acetyltransferase
KXZ66_RS03725	COG5578	integral membrane protein
KXZ66_RS03730	COG2972	Histidine kinase
KXZ66_RS03735	COG2207	Transcriptional regulator
KXZ66_RS03735	COG4753	response regulator
KXZ66_RS03740	COG1653	transport
KXZ66_RS03745	COG1175	transmembrane transport
KXZ66_RS03750	COG0395	ABC-type sugar transport system, permease component
KXZ66_RS03755	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KXZ66_RS03760	COG2207	Transcriptional regulator
KXZ66_RS03765	COG2755	lipolytic protein G-D-S-L family
KXZ66_RS03775	COG5578	integral membrane protein
KXZ66_RS03780	COG3401	FG-GAP repeat protein
KXZ66_RS03785	COG3401	FG-GAP repeat protein
KXZ66_RS03790	COG2755	lipolytic protein G-D-S-L family
KXZ66_RS03795	COG1874	Beta-galactosidase
KXZ66_RS03805	COG1653	transport
KXZ66_RS03810	COG4209	transmembrane transport
KXZ66_RS03815	COG0395	ABC-type sugar transport system, permease component
KXZ66_RS03820	COG1486	melibiose metabolic process
KXZ66_RS03825	COG2323	membrane
KXZ66_RS03830	COG2329	Antibiotic biosynthesis monooxygenase
KXZ66_RS03835	COG0346	lactoylglutathione lyase activity
KXZ66_RS03850	COG5583	Uncharacterized small protein (DUF2292)
KXZ66_RS03855	COG0670	Belongs to the BI1 family
KXZ66_RS03860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KXZ66_RS03865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KXZ66_RS03870	COG0134	indole-3-glycerol-phosphate synthase activity
KXZ66_RS03875	COG0133	tryptophan synthase activity
KXZ66_RS03880	COG0159	tryptophan synthase activity
KXZ66_RS03885	COG0135	phosphoribosylanthranilate isomerase activity
KXZ66_RS03910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KXZ66_RS03920	COG0673	inositol 2-dehydrogenase activity
KXZ66_RS03930	COG0072	phenylalanine-tRNA ligase activity
KXZ66_RS03945	COG1846	Transcriptional regulator
KXZ66_RS03950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KXZ66_RS03965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KXZ66_RS03965	COG2124	cytochrome p450
KXZ66_RS03970	COG1368	sulfuric ester hydrolase activity
KXZ66_RS03975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KXZ66_RS03980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KXZ66_RS03985	COG1442	glycosyl transferase family 8
KXZ66_RS03990	COG1216	Glycosyl transferase, family 2
KXZ66_RS03995	COG1442	glycosyl transferase family 8
KXZ66_RS04000	COG2223	nitrite transmembrane transporter activity
KXZ66_RS04010	COG0531	amino acid
KXZ66_RS04015	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS04020	COG0840	transmembrane signaling receptor activity
KXZ66_RS04025	COG0488	(ABC) transporter
KXZ66_RS04035	COG0789	Transcriptional regulator
KXZ66_RS04040	COG2814	Major facilitator Superfamily
KXZ66_RS04050	COG0488	(ABC) transporter
KXZ66_RS04055	COG0513	Belongs to the DEAD box helicase family
KXZ66_RS04060	COG0456	acetyltransferase
KXZ66_RS04065	COG2130	NADP-dependent
KXZ66_RS04070	COG1120	ATPase activity
KXZ66_RS04075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS04085	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KXZ66_RS04100	COG3866	Pectate lyase
KXZ66_RS04105	COG0471	metal ion transport
KXZ66_RS04110	COG3290	protein histidine kinase activity
KXZ66_RS04115	COG4565	transcriptional regulatory protein
KXZ66_RS04120	COG3181	Tripartite tricarboxylate transporter family receptor
KXZ66_RS04125	COG2851	Citrate transporter
KXZ66_RS04130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KXZ66_RS04135	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KXZ66_RS04140	COG1254	Belongs to the acylphosphatase family
KXZ66_RS04145	COG2258	MOSC domain
KXZ66_RS04165	COG0024	Methionine aminopeptidase
KXZ66_RS04170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS04170	COG1263	PTS System
KXZ66_RS04175	COG1368	sulfuric ester hydrolase activity
KXZ66_RS04190	COG1115	amino acid carrier protein
KXZ66_RS04195	COG0531	amino acid
KXZ66_RS04210	COG0697	spore germination
KXZ66_RS04215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS04215	COG1263	PTS System
KXZ66_RS04220	COG0366	Alpha amylase catalytic
KXZ66_RS04225	COG2188	Transcriptional regulator
KXZ66_RS04230	COG0778	Nitroreductase
KXZ66_RS04235	COG0737	Belongs to the 5'-nucleotidase family
KXZ66_RS04240	COG0693	protein deglycase activity
KXZ66_RS04245	COG2814	Major facilitator Superfamily
KXZ66_RS04250	COG4840	Belongs to the UPF0435 family
KXZ66_RS04255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KXZ66_RS04260	COG4980	gas vesicle protein
KXZ66_RS04265	COG1295	ribonuclease BN
KXZ66_RS04270	COG0477	Major facilitator Superfamily
KXZ66_RS04275	COG0387	Pfam Sodium calcium exchanger
KXZ66_RS04285	COG0668	transmembrane transport
KXZ66_RS04290	COG0535	radical SAM domain protein
KXZ66_RS04300	COG0726	polysaccharide deacetylase
KXZ66_RS04305	COG2084	Dehydrogenase
KXZ66_RS04310	COG0598	Magnesium transport protein CorA
KXZ66_RS04315	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KXZ66_RS04320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KXZ66_RS04330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KXZ66_RS04335	COG4637	Psort location Cytoplasmic, score
KXZ66_RS04340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KXZ66_RS04345	COG0022	dehydrogenase e1 component
KXZ66_RS04350	COG0508	dehydrogenase complex catalyzes the overall conversion of
KXZ66_RS04355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KXZ66_RS04360	COG3284	Transcriptional regulator
KXZ66_RS04370	COG1742	UPF0060 membrane protein
KXZ66_RS04395	COG4842	Belongs to the WXG100 family
KXZ66_RS04400	COG1486	melibiose metabolic process
KXZ66_RS04405	COG1737	Transcriptional regulator
KXZ66_RS04410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS04410	COG1263	PTS System
KXZ66_RS04415	COG5434	Belongs to the glycosyl hydrolase 28 family
KXZ66_RS04420	COG1132	(ABC) transporter
KXZ66_RS04425	COG1132	(ABC) transporter
KXZ66_RS04430	COG2259	Doxx family
KXZ66_RS04435	COG2514	catechol 2,3-dioxygenase activity
KXZ66_RS04440	COG4585	Histidine kinase
KXZ66_RS04445	COG2197	response regulator
KXZ66_RS04450	COG1131	(ABC) transporter
KXZ66_RS04455	COG0842	Transport permease protein
KXZ66_RS04455	COG1511	domain protein
KXZ66_RS04460	COG0842	Transport permease protein
KXZ66_RS04465	COG1695	Transcriptional regulator
KXZ66_RS04470	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KXZ66_RS04475	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
KXZ66_RS04480	COG2318	DinB family
KXZ66_RS04485	COG2814	Major facilitator Superfamily
KXZ66_RS04490	COG1846	Transcriptional regulator
KXZ66_RS04495	COG0392	lysyltransferase activity
KXZ66_RS04495	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KXZ66_RS04500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KXZ66_RS04505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS04510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS04515	COG0384	phenazine biosynthesis protein PhzF
KXZ66_RS04520	COG0778	Nitroreductase
KXZ66_RS04535	COG1090	epimerase
KXZ66_RS04540	COG2137	regulation of response to DNA damage stimulus
KXZ66_RS04550	COG2814	Major facilitator Superfamily
KXZ66_RS04565	COG3103	Sh3 type 3 domain protein
KXZ66_RS04570	COG5658	integral membrane protein
KXZ66_RS04575	COG0596	Alpha beta hydrolase
KXZ66_RS04580	COG0463	Glycosyl transferase, family 2
KXZ66_RS04585	COG4485	Bacterial membrane protein, YfhO
KXZ66_RS04590	COG1988	membrane-bound metal-dependent
KXZ66_RS04595	COG1194	a g-specific adenine glycosylase
KXZ66_RS04605	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS04620	COG3557	Belongs to the UPF0374 family
KXZ66_RS04625	COG1132	(ABC) transporter
KXZ66_RS04630	COG4129	membrane
KXZ66_RS04635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KXZ66_RS04640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KXZ66_RS04645	COG0735	belongs to the Fur family
KXZ66_RS04765	COG5577	PFAM Coat F domain
KXZ66_RS04770	COG3340	Belongs to the peptidase S51 family
KXZ66_RS04775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KXZ66_RS04790	COG0753	catalase activity
KXZ66_RS04795	COG1116	anion transmembrane transporter activity
KXZ66_RS04800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KXZ66_RS04805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KXZ66_RS04810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KXZ66_RS04820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KXZ66_RS04830	COG1476	TRANSCRIPTIONal
KXZ66_RS04840	COG3382	B3 4 domain protein
KXZ66_RS04845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KXZ66_RS04855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KXZ66_RS04860	COG0789	Transcriptional regulator
KXZ66_RS04865	COG1664	Polymer-forming cytoskeletal
KXZ66_RS04870	COG1664	Polymer-forming cytoskeletal
KXZ66_RS04875	COG2766	serine protein kinase
KXZ66_RS04880	COG2718	Belongs to the UPF0229 family
KXZ66_RS04885	COG1846	Transcriptional regulator
KXZ66_RS04890	COG1566	PFAM secretion protein HlyD family protein
KXZ66_RS04895	COG2814	Major facilitator Superfamily
KXZ66_RS04900	COG0655	NAD(P)H dehydrogenase (quinone) activity
KXZ66_RS04920	COG1725	Transcriptional regulator
KXZ66_RS04925	COG1131	(ABC) transporter
KXZ66_RS04930	COG1131	(ABC) transporter
KXZ66_RS04935	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KXZ66_RS04940	COG1278	Cold shock
KXZ66_RS04945	COG1464	Belongs to the NlpA lipoprotein family
KXZ66_RS04950	COG3706	GGDEF domain
KXZ66_RS04955	COG1823	symporter activity
KXZ66_RS04990	COG5577	PFAM Coat F domain
KXZ66_RS04995	COG4085	toxin activity
KXZ66_RS04995	COG0737	Belongs to the 5'-nucleotidase family
KXZ66_RS04995	COG1525	nuclease
KXZ66_RS05000	COG3764	Sortase (surface protein transpeptidase)
KXZ66_RS05005	COG0564	pseudouridine synthase activity
KXZ66_RS05015	COG0517	IMP dehydrogenase activity
KXZ66_RS05020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KXZ66_RS05025	COG3153	acetyltransferase
KXZ66_RS05025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KXZ66_RS05030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KXZ66_RS05035	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KXZ66_RS05040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KXZ66_RS05045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KXZ66_RS05050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KXZ66_RS05055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KXZ66_RS05060	COG2203	Gaf domain
KXZ66_RS05060	COG4585	Histidine kinase
KXZ66_RS05065	COG2197	response regulator
KXZ66_RS05070	COG0431	NADPH-dependent FMN reductase
KXZ66_RS05085	COG1388	LysM domain
KXZ66_RS05085	COG0791	NLP P60 protein
KXZ66_RS05090	COG1959	2 iron, 2 sulfur cluster binding
KXZ66_RS05095	COG0668	transmembrane transport
KXZ66_RS05100	COG2719	SpoVR family
KXZ66_RS05105	COG1785	Belongs to the alkaline phosphatase family
KXZ66_RS05110	COG0791	NLP P60 protein
KXZ66_RS05110	COG1388	LysM domain
KXZ66_RS05115	COG0583	DNA-binding transcription factor activity
KXZ66_RS05120	COG0372	Belongs to the citrate synthase family
KXZ66_RS05125	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS05130	COG0531	amino acid
KXZ66_RS05135	COG0733	neurotransmitter:sodium symporter activity
KXZ66_RS05140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KXZ66_RS05145	COG0456	acetyltransferase
KXZ66_RS05160	COG1595	DNA-templated transcription, initiation
KXZ66_RS05165	COG0667	Aldo Keto reductase
KXZ66_RS05170	COG0204	Acyl-transferase
KXZ66_RS05175	COG1253	flavin adenine dinucleotide binding
KXZ66_RS05180	COG0789	Transcriptional regulator
KXZ66_RS05185	COG0436	Aminotransferase
KXZ66_RS05190	COG1253	flavin adenine dinucleotide binding
KXZ66_RS05195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KXZ66_RS05200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KXZ66_RS05205	COG0584	glycerophosphoryl diester phosphodiesterase
KXZ66_RS05215	COG0668	transmembrane transport
KXZ66_RS05220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KXZ66_RS05225	COG0726	polysaccharide deacetylase
KXZ66_RS05230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KXZ66_RS05235	COG1757	Na H antiporter
KXZ66_RS05240	COG0589	response to stress
KXZ66_RS05250	COG1132	(ABC) transporter
KXZ66_RS05255	COG1132	(ABC) transporter
KXZ66_RS05260	COG0702	epimerase
KXZ66_RS05280	COG0189	ligase activity
KXZ66_RS05285	COG0189	ligase activity
KXZ66_RS05290	COG4399	Belongs to the UPF0754 family
KXZ66_RS05295	COG3679	Belongs to the UPF0342 family
KXZ66_RS05300	COG4335	DNA alkylation repair
KXZ66_RS05305	COG0561	phosphatase activity
KXZ66_RS05310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KXZ66_RS05315	COG0475	glutathione-regulated potassium exporter activity
KXZ66_RS05320	COG0490	domain, Protein
KXZ66_RS05330	COG1024	Enoyl-CoA hydratase
KXZ66_RS05340	COG4152	abc transporter atp-binding protein
KXZ66_RS05345	COG1668	transmembrane transport
KXZ66_RS05350	COG0420	3'-5' exonuclease activity
KXZ66_RS05355	COG4717	serine-type aminopeptidase activity
KXZ66_RS05360	COG3481	metal-dependent phosphohydrolase, HD sub domain
KXZ66_RS05370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KXZ66_RS05400	COG1846	Transcriptional regulator
KXZ66_RS05405	COG4980	gas vesicle protein
KXZ66_RS05420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KXZ66_RS05425	COG0537	adenosine 5'-monophosphoramidase activity
KXZ66_RS05430	COG1131	(ABC) transporter
KXZ66_RS05435	COG4473	ABC transporter
KXZ66_RS05445	COG1473	amidohydrolase
KXZ66_RS05450	COG3069	C4-dicarboxylate transmembrane transporter activity
KXZ66_RS05460	COG2329	Antibiotic biosynthesis monooxygenase
KXZ66_RS05465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KXZ66_RS05470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KXZ66_RS05475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KXZ66_RS05480	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KXZ66_RS05485	COG1309	transcriptional regulator
KXZ66_RS05490	COG1511	domain protein
KXZ66_RS05495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KXZ66_RS05500	COG4377	Putative membrane peptidase family (DUF2324)
KXZ66_RS05510	COG1363	Peptidase, m42
KXZ66_RS05515	COG4405	Protein conserved in bacteria
KXZ66_RS05520	COG1301	dicarboxylic acid transport
KXZ66_RS05530	COG1234	tRNA 3'-trailer cleavage
KXZ66_RS05535	COG0095	Lipoate-protein ligase
KXZ66_RS05540	COG0702	epimerase
KXZ66_RS05545	COG0318	PFAM AMP-dependent synthetase and ligase
KXZ66_RS05555	COG0501	Belongs to the peptidase M48B family
KXZ66_RS05565	COG0456	acetyltransferase
KXZ66_RS05570	COG0604	alcohol dehydrogenase
KXZ66_RS05575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KXZ66_RS05580	COG0406	alpha-ribazole phosphatase activity
KXZ66_RS05585	COG0183	Belongs to the thiolase family
KXZ66_RS05590	COG0318	PFAM AMP-dependent synthetase and ligase
KXZ66_RS05595	COG1268	BioY protein
KXZ66_RS05600	COG0840	transmembrane signaling receptor activity
KXZ66_RS05605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KXZ66_RS05605	COG0723	plastoquinol--plastocyanin reductase activity
KXZ66_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS05620	COG4903	ComK protein
KXZ66_RS05625	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS05635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KXZ66_RS05650	COG0398	Pfam SNARE associated Golgi protein
KXZ66_RS05655	COG0681	Belongs to the peptidase S26 family
KXZ66_RS05660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KXZ66_RS05665	COG1846	Transcriptional regulator
KXZ66_RS05675	COG0738	Major facilitator superfamily
KXZ66_RS05680	COG0673	inositol 2-dehydrogenase activity
KXZ66_RS05685	COG0561	phosphatase activity
KXZ66_RS05690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KXZ66_RS05695	COG1609	Transcriptional regulator
KXZ66_RS05700	COG3180	Ammonia monooxygenase
KXZ66_RS05705	COG0477	Major facilitator Superfamily
KXZ66_RS05705	COG2814	Major facilitator Superfamily
KXZ66_RS05710	COG4533	DNA binding
KXZ66_RS05720	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KXZ66_RS05725	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KXZ66_RS05730	COG1074	ATP-dependent DNA helicase activity
KXZ66_RS05735	COG0420	3'-5' exonuclease activity
KXZ66_RS05740	COG0419	ATPase involved in DNA repair
KXZ66_RS05745	COG1403	HNH endonuclease
KXZ66_RS05785	COG5337	Spore coat protein CotH
KXZ66_RS05790	COG0179	Fumarylacetoacetate (FAA) hydrolase
KXZ66_RS05800	COG1404	Belongs to the peptidase S8 family
KXZ66_RS05810	COG0367	asparagine synthase
KXZ66_RS05815	COG2318	DinB family
KXZ66_RS05825	COG0534	Mate efflux family protein
KXZ66_RS05830	COG2207	Transcriptional regulator
KXZ66_RS05830	COG1917	Cupin 2, conserved barrel domain protein
KXZ66_RS05835	COG1609	Transcriptional regulator
KXZ66_RS05840	COG0673	inositol 2-dehydrogenase activity
KXZ66_RS05845	COG2318	DinB family
KXZ66_RS05850	COG1279	arginine transmembrane transporter activity
KXZ66_RS05855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KXZ66_RS05860	COG1357	PFAM Pentapeptide repeats (8 copies)
KXZ66_RS05865	COG2267	carboxylic ester hydrolase activity
KXZ66_RS05870	COG0529	Catalyzes the synthesis of activated sulfate
KXZ66_RS05875	COG2046	Belongs to the sulfate adenylyltransferase family
KXZ66_RS05880	COG0175	sulfate reduction
KXZ66_RS05885	COG2045	Belongs to the ComB family
KXZ66_RS05890	COG1809	phosphosulfolactate synthase activity
KXZ66_RS05895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KXZ66_RS05900	COG4948	Mandelate Racemase Muconate Lactonizing
KXZ66_RS05905	COG2814	Major facilitator Superfamily
KXZ66_RS05910	COG0454	-acetyltransferase
KXZ66_RS05915	COG2153	protein acetylation
KXZ66_RS05920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KXZ66_RS05920	COG0646	methionine synthase
KXZ66_RS05925	COG1666	GTP binding
KXZ66_RS05930	COG2996	Protein conserved in bacteria
KXZ66_RS05950	COG1695	Transcriptional regulator
KXZ66_RS05965	COG3227	Zinc metalloprotease (Elastase)
KXZ66_RS05970	COG1307	EDD domain protein, DegV family
KXZ66_RS05975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KXZ66_RS05995	COG0561	phosphatase activity
KXZ66_RS06000	COG1073	alpha beta
KXZ66_RS06005	COG2151	metal-sulfur cluster biosynthetic enzyme
KXZ66_RS06015	COG0277	FAD linked oxidase domain protein
KXZ66_RS06020	COG2271	Major facilitator Superfamily
KXZ66_RS06025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KXZ66_RS06030	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KXZ66_RS06040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KXZ66_RS06045	COG0505	Belongs to the CarA family
KXZ66_RS06050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KXZ66_RS06055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KXZ66_RS06070	COG2267	carboxylic ester hydrolase activity
KXZ66_RS06080	COG1744	ABC transporter substrate-binding protein PnrA-like
KXZ66_RS06095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KXZ66_RS06100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KXZ66_RS06105	COG5504	Zn-dependent protease
KXZ66_RS06110	COG0444	Belongs to the ABC transporter superfamily
KXZ66_RS06115	COG4608	Belongs to the ABC transporter superfamily
KXZ66_RS06125	COG0601	transmembrane transport
KXZ66_RS06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KXZ66_RS06140	COG0180	Tryptophanyl-tRNA synthetase
KXZ66_RS06145	COG4166	transmembrane transport
KXZ66_RS06150	COG0601	transmembrane transport
KXZ66_RS06155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KXZ66_RS06160	COG0444	Belongs to the ABC transporter superfamily
KXZ66_RS06165	COG4608	Belongs to the ABC transporter superfamily
KXZ66_RS06170	COG2814	Major facilitator Superfamily
KXZ66_RS06175	COG0456	acetyltransferase
KXZ66_RS06180	COG1393	Belongs to the ArsC family
KXZ66_RS06185	COG0861	Integral membrane protein TerC family
KXZ66_RS06195	COG4862	establishment of competence for transformation
KXZ66_RS06205	COG4469	Competence protein
KXZ66_RS06210	COG1164	Oligoendopeptidase f
KXZ66_RS06220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KXZ66_RS06225	COG2346	COG2346, Truncated hemoglobins
KXZ66_RS06230	COG0741	lytic transglycosylase activity
KXZ66_RS06235	COG4116	CYTH
KXZ66_RS06245	COG2357	RelA SpoT domain protein
KXZ66_RS06250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KXZ66_RS06255	COG0564	pseudouridine synthase activity
KXZ66_RS06260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KXZ66_RS06265	COG0569	domain protein
KXZ66_RS06265	COG0475	glutathione-regulated potassium exporter activity
KXZ66_RS06270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KXZ66_RS06275	COG0352	thiamine-phosphate diphosphorylase activity
KXZ66_RS06280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KXZ66_RS06285	COG2104	thiamine diphosphate biosynthetic process
KXZ66_RS06290	COG2022	thiamine diphosphate biosynthetic process
KXZ66_RS06295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KXZ66_RS06300	COG0351	phosphomethylpyrimidine kinase
KXZ66_RS06305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KXZ66_RS06360	COG0210	DNA helicase
KXZ66_RS06370	COG2153	protein acetylation
KXZ66_RS06375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KXZ66_RS06380	COG2382	esterase
KXZ66_RS06385	COG0626	cystathionine gamma-synthase activity
KXZ66_RS06390	COG0626	cystathionine gamma-synthase activity
KXZ66_RS06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KXZ66_RS06400	COG5505	Protein of unknown function (DUF819)
KXZ66_RS06420	COG5444	nuclease activity
KXZ66_RS06445	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KXZ66_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS06460	COG3711	transcriptional antiterminator
KXZ66_RS06460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KXZ66_RS06465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KXZ66_RS06465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KXZ66_RS06465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KXZ66_RS06470	COG1482	cell wall glycoprotein biosynthetic process
KXZ66_RS06480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KXZ66_RS06490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KXZ66_RS06505	COG0109	protoheme IX farnesyltransferase activity
KXZ66_RS06515	COG0726	polysaccharide deacetylase
KXZ66_RS06535	COG2205	protein histidine kinase activity
KXZ66_RS06545	COG3383	formate dehydrogenase (NAD+) activity
KXZ66_RS06550	COG2427	Protein of unknown function (DUF1641)
KXZ66_RS06560	COG1051	belongs to the nudix hydrolase family
KXZ66_RS06570	COG2124	cytochrome p450
KXZ66_RS06575	COG1819	glycosyl
KXZ66_RS06585	COG1587	Uroporphyrinogen-III synthase
KXZ66_RS06590	COG0390	transport system, permease component
KXZ66_RS06595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KXZ66_RS06600	COG0697	spore germination
KXZ66_RS06605	COG4297	protein containing double-stranded beta helix domain
KXZ66_RS06615	COG1252	NADH dehydrogenase
KXZ66_RS06620	COG1904	glucuronate isomerase
KXZ66_RS06625	COG2211	Major facilitator Superfamily
KXZ66_RS06630	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
KXZ66_RS06635	COG1063	alcohol dehydrogenase
KXZ66_RS06640	COG1312	Catalyzes the dehydration of D-mannonate
KXZ66_RS06645	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS06650	COG2271	Major facilitator Superfamily
KXZ66_RS06655	COG1609	Transcriptional regulator
KXZ66_RS06660	COG0246	Mannitol dehydrogenase
KXZ66_RS06665	COG2721	sulfolactate sulfo-lyase activity
KXZ66_RS06670	COG0730	response to heat
KXZ66_RS06675	COG2318	DinB family
KXZ66_RS06680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KXZ66_RS06685	COG0457	Tetratricopeptide repeat
KXZ66_RS06695	COG2350	Protein conserved in bacteria
KXZ66_RS06700	COG3409	Peptidoglycan-binding domain 1 protein
KXZ66_RS06700	COG5632	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS06700	COG1388	LysM domain
KXZ66_RS06710	COG4195	phage-related replication protein
KXZ66_RS06715	COG3546	catalase activity
KXZ66_RS06720	COG2856	Zn peptidase
KXZ66_RS06725	COG1396	sequence-specific DNA binding
KXZ66_RS06735	COG1522	sequence-specific DNA binding
KXZ66_RS06740	COG1484	DNA-dependent DNA replication
KXZ66_RS06760	COG1595	DNA-templated transcription, initiation
KXZ66_RS06765	COG5484	DNA packaging
KXZ66_RS06765	COG3728	DNA packaging
KXZ66_RS06770	COG1783	phage Terminase large subunit
KXZ66_RS06775	COG5518	Phage portal protein
KXZ66_RS06780	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KXZ66_RS06785	COG4653	Phage capsid family
KXZ66_RS06835	COG3953	SLT domain
KXZ66_RS06835	COG5412	phage tail tape measure protein
KXZ66_RS06835	COG3953	SLT domain
KXZ66_RS06835	COG5412	phage tail tape measure protein
KXZ66_RS06840	COG1652	LysM domain
KXZ66_RS06845	COG4193	domain, Protein
KXZ66_RS06855	COG3628	GPW Gp25 family protein
KXZ66_RS06860	COG3299	homolog of phage Mu protein gp47
KXZ66_RS06865	COG3778	Protein conserved in bacteria
KXZ66_RS06905	COG3409	Peptidoglycan-binding domain 1 protein
KXZ66_RS06905	COG5632	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS06925	COG0306	phosphate transporter
KXZ66_RS06930	COG1392	Phosphate transport regulator
KXZ66_RS06935	COG0531	amino acid
KXZ66_RS06940	COG0346	lactoylglutathione lyase activity
KXZ66_RS06950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KXZ66_RS06955	COG0463	Glycosyl transferase, family 2
KXZ66_RS06965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KXZ66_RS06970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KXZ66_RS06975	COG2362	D-Aminopeptidase
KXZ66_RS06980	COG0601	transmembrane transport
KXZ66_RS06985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KXZ66_RS06990	COG0444	Belongs to the ABC transporter superfamily
KXZ66_RS06995	COG4166	transmembrane transport
KXZ66_RS07000	COG1619	proteins homologs of microcin C7 resistance protein MccF
KXZ66_RS07005	COG4948	Mandelate Racemase Muconate Lactonizing
KXZ66_RS07010	COG0791	NLP P60 protein
KXZ66_RS07015	COG4608	Belongs to the ABC transporter superfamily
KXZ66_RS07020	COG2706	6-phosphogluconolactonase activity
KXZ66_RS07025	COG1834	amidinotransferase
KXZ66_RS07030	COG1607	acyl-coa hydrolase
KXZ66_RS07035	COG1017	nitric oxide dioxygenase activity
KXZ66_RS07035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KXZ66_RS07045	COG2323	membrane
KXZ66_RS07050	COG2318	DinB family
KXZ66_RS07055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KXZ66_RS07060	COG2076	Multidrug Resistance protein
KXZ66_RS07065	COG2076	Multidrug Resistance protein
KXZ66_RS07070	COG0788	formyltetrahydrofolate deformylase activity
KXZ66_RS07075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KXZ66_RS07080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KXZ66_RS07085	COG1764	response to oxidative stress
KXZ66_RS07090	COG1846	Transcriptional regulator
KXZ66_RS07095	COG1764	response to oxidative stress
KXZ66_RS07105	COG0590	tRNA wobble adenosine to inosine editing
KXZ66_RS07110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KXZ66_RS07115	COG1404	Belongs to the peptidase S8 family
KXZ66_RS07120	COG1366	Belongs to the anti-sigma-factor antagonist family
KXZ66_RS07125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KXZ66_RS07130	COG1122	ATPase activity
KXZ66_RS07135	COG4721	ABC-type cobalt transport system, permease component
KXZ66_RS07145	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS07150	COG3850	Histidine kinase
KXZ66_RS07150	COG5002	protein histidine kinase activity
KXZ66_RS07155	COG3212	peptidase
KXZ66_RS07160	COG3212	peptidase
KXZ66_RS07170	COG2239	Acts as a magnesium transporter
KXZ66_RS07175	COG0789	Transcriptional regulator
KXZ66_RS07190	COG1846	Transcriptional regulator
KXZ66_RS07195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KXZ66_RS07200	COG0726	polysaccharide deacetylase
KXZ66_RS07205	COG1408	metallophosphoesterase
KXZ66_RS07215	COG0463	Glycosyl transferase, family 2
KXZ66_RS07220	COG1793	dna ligase
KXZ66_RS07220	COG3285	dna ligase
KXZ66_RS07225	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KXZ66_RS07230	COG5001	Diguanylate cyclase
KXZ66_RS07230	COG3300	MHYT domain
KXZ66_RS07235	COG0586	Pfam SNARE associated Golgi protein
KXZ66_RS07240	COG0861	Integral membrane protein TerC family
KXZ66_RS07245	COG1191	sigma factor activity
KXZ66_RS07265	COG0501	Belongs to the peptidase M48B family
KXZ66_RS07270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KXZ66_RS07285	COG3594	Acyltransferase
KXZ66_RS07290	COG5002	protein histidine kinase activity
KXZ66_RS07295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KXZ66_RS07305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KXZ66_RS07310	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
KXZ66_RS07315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KXZ66_RS07320	COG0436	Aminotransferase
KXZ66_RS07325	COG1850	ribulose-bisphosphate carboxylase activity
KXZ66_RS07330	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
KXZ66_RS07335	COG0235	Class ii aldolase
KXZ66_RS07340	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KXZ66_RS07345	COG3339	Conserved Protein
KXZ66_RS07360	COG3852	Histidine kinase
KXZ66_RS07365	COG1846	Transcriptional regulator
KXZ66_RS07370	COG1360	Flagellar Motor Protein
KXZ66_RS07375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KXZ66_RS07380	COG0542	response to heat
KXZ66_RS07385	COG3949	Membrane
KXZ66_RS07390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KXZ66_RS07395	COG0720	synthase
KXZ66_RS07400	COG0602	queuosine metabolic process
KXZ66_RS07405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KXZ66_RS07410	COG1733	regulation of RNA biosynthetic process
KXZ66_RS07415	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS07420	COG4641	Protein conserved in bacteria
KXZ66_RS07420	COG1388	LysM domain
KXZ66_RS07425	COG1388	LysM domain
KXZ66_RS07430	COG3858	chitin binding
KXZ66_RS07440	COG4873	Protein conserved in bacteria
KXZ66_RS07450	COG3773	Cell wall hydrolase
KXZ66_RS07455	COG2244	polysaccharide biosynthetic process
KXZ66_RS07460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS07465	COG2217	Heavy metal translocating P-type atpase
KXZ66_RS07475	COG0006	proline dipeptidase activity
KXZ66_RS07480	COG1609	Transcriptional regulator
KXZ66_RS07485	COG3711	transcriptional antiterminator
KXZ66_RS07490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS07490	COG2190	(PTS) system
KXZ66_RS07490	COG1263	PTS System
KXZ66_RS07495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KXZ66_RS07500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KXZ66_RS07510	COG1533	DNA photolyase activity
KXZ66_RS07515	COG0456	acetyltransferase
KXZ66_RS07520	COG0840	transmembrane signaling receptor activity
KXZ66_RS07525	COG2084	Dehydrogenase
KXZ66_RS07530	COG4257	antibiotic catabolic process
KXZ66_RS07535	COG2340	Cysteine-rich secretory protein family
KXZ66_RS07540	COG0768	penicillin binding
KXZ66_RS07545	COG4191	Histidine kinase
KXZ66_RS07550	COG0436	Aminotransferase
KXZ66_RS07560	COG0835	chemotaxis
KXZ66_RS07560	COG0784	Response regulator, receiver
KXZ66_RS07570	COG2814	Major facilitator Superfamily
KXZ66_RS07575	COG1376	ErfK ybiS ycfS ynhG family protein
KXZ66_RS07580	COG1408	metallophosphoesterase
KXZ66_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS07590	COG2200	EAL domain
KXZ66_RS07595	COG4703	Protein of unknown function (DUF1797)
KXZ66_RS07600	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KXZ66_RS07610	COG0517	IMP dehydrogenase activity
KXZ66_RS07615	COG0583	DNA-binding transcription factor activity
KXZ66_RS07620	COG0716	FMN binding
KXZ66_RS07630	COG0716	FMN binding
KXZ66_RS07635	COG2171	N-acyltransferase activity
KXZ66_RS07640	COG1473	amidohydrolase
KXZ66_RS07650	COG0668	transmembrane transport
KXZ66_RS07655	COG0450	alkyl hydroperoxide reductase
KXZ66_RS07660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS07675	COG0746	molybdenum cofactor guanylyltransferase activity
KXZ66_RS07680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KXZ66_RS07685	COG0303	'Molybdopterin
KXZ66_RS07690	COG1763	Mo-molybdopterin cofactor biosynthetic process
KXZ66_RS07695	COG0314	molybdopterin synthase activity
KXZ66_RS07700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KXZ66_RS07705	COG1132	(ABC) transporter
KXZ66_RS07710	COG1132	(ABC) transporter
KXZ66_RS07720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KXZ66_RS07725	COG1136	(ABC) transporter
KXZ66_RS07730	COG0577	efflux transmembrane transporter activity
KXZ66_RS07735	COG1349	DNA-binding transcription factor activity
KXZ66_RS07740	COG1105	Belongs to the carbohydrate kinase PfkB family
KXZ66_RS07745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KXZ66_RS07745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KXZ66_RS07745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KXZ66_RS07750	COG0681	Belongs to the peptidase S26 family
KXZ66_RS07760	COG0488	(ABC) transporter
KXZ66_RS07765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KXZ66_RS07770	COG2309	aminopeptidase activity
KXZ66_RS07780	COG1077	Cell shape determining protein MreB Mrl
KXZ66_RS07785	COG2002	toxin-antitoxin pair type II binding
KXZ66_RS07790	COG3852	Histidine kinase
KXZ66_RS07795	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
KXZ66_RS07795	COG2105	PFAM AIG2 family protein
KXZ66_RS07800	COG0569	domain protein
KXZ66_RS07805	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KXZ66_RS07810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KXZ66_RS07815	COG5503	Protein of unknown function (DUF1447)
KXZ66_RS07820	COG0561	phosphatase activity
KXZ66_RS07825	COG0242	peptide deformylase activity
KXZ66_RS07835	COG0497	DNA recombination
KXZ66_RS07840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KXZ66_RS07845	COG0022	dehydrogenase e1 component
KXZ66_RS07850	COG0508	dehydrogenase complex catalyzes the overall conversion of
KXZ66_RS07855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KXZ66_RS07860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS07870	COG1982	Orn Lys Arg decarboxylase major
KXZ66_RS07875	COG4476	Belongs to the UPF0223 family
KXZ66_RS07880	COG4493	Belongs to the UPF0637 family
KXZ66_RS07890	COG0483	inositol monophosphate 1-phosphatase activity
KXZ66_RS07900	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KXZ66_RS07920	COG1595	DNA-templated transcription, initiation
KXZ66_RS07940	COG1217	gtp-binding protein TYPA
KXZ66_RS07950	COG4896	Protein conserved in bacteria
KXZ66_RS07960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KXZ66_RS07965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KXZ66_RS07970	COG2066	Belongs to the glutaminase family
KXZ66_RS07975	COG4838	Belongs to the UPF0358 family
KXZ66_RS07980	COG0772	Belongs to the SEDS family
KXZ66_RS07985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KXZ66_RS07990	COG1612	heme a metabolic process
KXZ66_RS07995	COG0109	protoheme IX farnesyltransferase activity
KXZ66_RS08000	COG2010	Cytochrome c
KXZ66_RS08000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KXZ66_RS08005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KXZ66_RS08010	COG1845	cytochrome c oxidase, subunit III
KXZ66_RS08015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KXZ66_RS08020	COG3336	cytochrome c oxidase
KXZ66_RS08030	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KXZ66_RS08035	COG2340	Cysteine-rich secretory protein family
KXZ66_RS08050	COG3679	Belongs to the UPF0342 family
KXZ66_RS08055	COG4471	UPF0298 protein
KXZ66_RS08060	COG0742	ribosomal rna small subunit methyltransferase
KXZ66_RS08065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KXZ66_RS08070	COG3314	Sporulation integral membrane protein YlbJ
KXZ66_RS08075	COG1752	Esterase of the alpha-beta hydrolase superfamily
KXZ66_RS08080	COG3480	Lon protease (S16) C-terminal proteolytic domain
KXZ66_RS08085	COG1323	Belongs to the UPF0348 family
KXZ66_RS08095	COG1399	metal-binding, possibly nucleic acid-binding protein
KXZ66_RS08110	COG0454	-acetyltransferase
KXZ66_RS08115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KXZ66_RS08120	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KXZ66_RS08125	COG2001	Belongs to the MraZ family
KXZ66_RS08130	COG0275	rRNA processing
KXZ66_RS08135	COG4839	cell division protein FtsL
KXZ66_RS08140	COG0768	penicillin binding
KXZ66_RS08145	COG0768	penicillin binding
KXZ66_RS08150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KXZ66_RS08155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KXZ66_RS08160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KXZ66_RS08165	COG0772	Belongs to the SEDS family
KXZ66_RS08170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KXZ66_RS08175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KXZ66_RS08180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KXZ66_RS08185	COG3879	Bacterial protein of unknown function (DUF881)
KXZ66_RS08190	COG3879	Bacterial protein of unknown function (DUF881)
KXZ66_RS08195	COG3856	small basic protein
KXZ66_RS08200	COG0849	cell division
KXZ66_RS08205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KXZ66_RS08210	COG4412	M6 family metalloprotease domain protein
KXZ66_RS08210	COG1404	Belongs to the peptidase S8 family
KXZ66_RS08220	COG1191	sigma factor activity
KXZ66_RS08225	COG1191	sigma factor activity
KXZ66_RS08230	COG1119	ATPase activity
KXZ66_RS08235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KXZ66_RS08240	COG1873	PFAM PRC-barrel domain
KXZ66_RS08245	COG1496	oxidoreductase activity
KXZ66_RS08250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KXZ66_RS08255	COG1799	cell septum assembly
KXZ66_RS08260	COG0762	integral membrane protein
KXZ66_RS08265	COG2302	S4 RNA-binding domain
KXZ66_RS08270	COG3599	regulation of cell shape
KXZ66_RS08275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KXZ66_RS08280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KXZ66_RS08285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KXZ66_RS08290	COG0564	pseudouridine synthase activity
KXZ66_RS08295	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KXZ66_RS08300	COG2233	PERMEase
KXZ66_RS08305	COG0540	Belongs to the ATCase OTCase family
KXZ66_RS08310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KXZ66_RS08315	COG0505	Belongs to the CarA family
KXZ66_RS08320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KXZ66_RS08325	COG0543	2 iron, 2 sulfur cluster binding
KXZ66_RS08330	COG0167	dihydroorotate dehydrogenase activity
KXZ66_RS08335	COG0284	orotidine-5'-phosphate decarboxylase activity
KXZ66_RS08340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KXZ66_RS08345	COG0175	sulfate reduction
KXZ66_RS08350	COG0306	phosphate transporter
KXZ66_RS08355	COG2046	Belongs to the sulfate adenylyltransferase family
KXZ66_RS08360	COG0529	Catalyzes the synthesis of activated sulfate
KXZ66_RS08365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KXZ66_RS08370	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
KXZ66_RS08375	COG1648	precorrin-2 dehydrogenase activity
KXZ66_RS08380	COG1293	RNA-binding protein homologous to eukaryotic snRNP
KXZ66_RS08385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KXZ66_RS08390	COG1561	YicC-like family, N-terminal region
KXZ66_RS08400	COG0194	GDP metabolic process
KXZ66_RS08405	COG1758	RNA polymerase activity
KXZ66_RS08410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KXZ66_RS08415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KXZ66_RS08420	COG0242	peptide deformylase activity
KXZ66_RS08425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KXZ66_RS08430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KXZ66_RS08430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KXZ66_RS08435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KXZ66_RS08440	COG0631	protein serine/threonine phosphatase activity
KXZ66_RS08445	COG0515	serine threonine protein kinase
KXZ66_RS08445	COG2815	serine threonine protein kinase
KXZ66_RS08450	COG1162	GTPase activity
KXZ66_RS08455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KXZ66_RS08460	COG1564	THIamine pyrophosphokinase
KXZ66_RS08470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KXZ66_RS08475	COG1302	Protein conserved in bacteria
KXZ66_RS08480	COG1461	Dihydroxyacetone kinase
KXZ66_RS08485	COG1760	l-serine dehydratase
KXZ66_RS08490	COG1760	l-serine dehydratase
KXZ66_RS08495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KXZ66_RS08500	COG1349	DNA-binding transcription factor activity
KXZ66_RS08500	COG2050	protein possibly involved in aromatic compounds catabolism
KXZ66_RS08505	COG0416	fatty acid biosynthetic process
KXZ66_RS08510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KXZ66_RS08515	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS08525	COG0571	ribonuclease III activity
KXZ66_RS08530	COG1196	nuclear chromosome segregation
KXZ66_RS08535	COG0552	protein localization to endoplasmic reticulum
KXZ66_RS08545	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KXZ66_RS08550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KXZ66_RS08555	COG0228	four-way junction DNA binding
KXZ66_RS08560	COG1837	Belongs to the UPF0109 family
KXZ66_RS08570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KXZ66_RS08575	COG0336	Belongs to the RNA methyltransferase TrmD family
KXZ66_RS08580	COG0335	large ribosomal subunit rRNA binding
KXZ66_RS08585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KXZ66_RS08590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KXZ66_RS08600	COG2257	FlhB HrpN YscU SpaS Family
KXZ66_RS08605	COG0045	succinate-CoA ligase (ADP-forming) activity
KXZ66_RS08610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KXZ66_RS08615	COG0758	DNA mediated transformation
KXZ66_RS08620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KXZ66_RS08625	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KXZ66_RS08630	COG4974	Belongs to the 'phage' integrase family
KXZ66_RS08635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KXZ66_RS08640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KXZ66_RS08645	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KXZ66_RS08650	COG1815	bacterial-type flagellum-dependent cell motility
KXZ66_RS08655	COG1558	bacterial-type flagellum-dependent cell motility
KXZ66_RS08660	COG1677	Flagellar hook-basal body complex protein FliE
KXZ66_RS08665	COG1766	The M ring may be actively involved in energy transduction
KXZ66_RS08670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KXZ66_RS08675	COG1317	bacterial-type flagellum organization
KXZ66_RS08680	COG1157	protein secretion by the type III secretion system
KXZ66_RS08685	COG2882	bacterial-type flagellum organization
KXZ66_RS08690	COG3334	PFAM MgtE intracellular
KXZ66_RS08695	COG3144	bacterial-type flagellum assembly
KXZ66_RS08700	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KXZ66_RS08705	COG4786	Flagellar basal body rod
KXZ66_RS08710	COG1582	Flagellar protein (FlbD)
KXZ66_RS08715	COG1580	Controls the rotational direction of flagella during chemotaxis
KXZ66_RS08720	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KXZ66_RS08725	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KXZ66_RS08725	COG1776	CheC inhibitor of MCP methylation
KXZ66_RS08730	COG2201	protein-glutamate methylesterase activity
KXZ66_RS08735	COG3190	flagellar
KXZ66_RS08740	COG1338	Plays a role in the flagellum-specific transport system
KXZ66_RS08745	COG1987	bacterial-type flagellum assembly
KXZ66_RS08750	COG1684	flagellar biosynthetic protein fliR
KXZ66_RS08755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KXZ66_RS08760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KXZ66_RS08765	COG1419	protein localization to endoplasmic reticulum
KXZ66_RS08770	COG0455	bacterial-type flagellum organization
KXZ66_RS08775	COG2201	protein-glutamate methylesterase activity
KXZ66_RS08780	COG2198	Histidine kinase
KXZ66_RS08780	COG0643	Histidine kinase
KXZ66_RS08785	COG0835	chemotaxis
KXZ66_RS08790	COG1776	CheC inhibitor of MCP methylation
KXZ66_RS08795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KXZ66_RS08800	COG1191	sigma factor activity
KXZ66_RS08810	COG0052	Belongs to the universal ribosomal protein uS2 family
KXZ66_RS08815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KXZ66_RS08820	COG0528	UMP kinase activity
KXZ66_RS08825	COG0233	cytoplasmic translational termination
KXZ66_RS08830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KXZ66_RS08835	COG4589	Belongs to the CDS family
KXZ66_RS08840	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KXZ66_RS08845	COG0750	zinc metalloprotease
KXZ66_RS08850	COG0442	prolyl-tRNA aminoacylation
KXZ66_RS08855	COG2176	DNA-directed DNA polymerase activity
KXZ66_RS08860	COG0779	Required for maturation of 30S ribosomal subunits
KXZ66_RS08865	COG0195	Participates in both transcription termination and antitermination
KXZ66_RS08870	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KXZ66_RS08875	COG1358	cellular component organization or biogenesis
KXZ66_RS08880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KXZ66_RS08885	COG1550	Protein conserved in bacteria
KXZ66_RS08890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KXZ66_RS08895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KXZ66_RS08900	COG0196	riboflavin kinase activity
KXZ66_RS08905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KXZ66_RS08910	COG1185	polyribonucleotide nucleotidyltransferase activity
KXZ66_RS08915	COG0726	polysaccharide deacetylase
KXZ66_RS08920	COG0612	Peptidase, M16
KXZ66_RS08925	COG1873	PFAM PRC-barrel domain
KXZ66_RS08930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KXZ66_RS08935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KXZ66_RS08940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KXZ66_RS08945	COG0527	aspartate kinase activity
KXZ66_RS08950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KXZ66_RS08955	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KXZ66_RS08960	COG0740	serine-type endopeptidase activity
KXZ66_RS08970	COG4980	gas vesicle protein
KXZ66_RS08970	COG1674	ftsk spoiiie
KXZ66_RS08975	COG2188	Transcriptional regulator
KXZ66_RS08980	COG2814	Major facilitator Superfamily
KXZ66_RS08985	COG0612	Peptidase, M16
KXZ66_RS08990	COG0612	Peptidase, M16
KXZ66_RS08995	COG0300	oxidoreductase activity
KXZ66_RS09010	COG1426	Protein conserved in bacteria
KXZ66_RS09015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KXZ66_RS09020	COG1546	Belongs to the CinA family
KXZ66_RS09020	COG1058	Belongs to the CinA family
KXZ66_RS09025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KXZ66_RS09030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KXZ66_RS09035	COG1418	mRNA catabolic process
KXZ66_RS09040	COG1692	metallophosphoesterase
KXZ66_RS09045	COG2359	stage V sporulation protein S
KXZ66_RS09050	COG1063	alcohol dehydrogenase
KXZ66_RS09055	COG0156	8-amino-7-oxononanoate synthase activity
KXZ66_RS09060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KXZ66_RS09065	COG4550	Control of competence regulator ComK, YlbF/YmcA
KXZ66_RS09075	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KXZ66_RS09080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KXZ66_RS09095	COG3226	Transcriptional regulator
KXZ66_RS09100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KXZ66_RS09110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KXZ66_RS09115	COG3321	synthase
KXZ66_RS09120	COG2070	2-Nitropropane dioxygenase
KXZ66_RS09120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KXZ66_RS09125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KXZ66_RS09130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KXZ66_RS09135	COG3425	synthase
KXZ66_RS09140	COG1024	Enoyl-CoA hydratase
KXZ66_RS09145	COG1024	Enoyl-CoA hydratase
KXZ66_RS09150	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS09150	COG0318	PFAM AMP-dependent synthetase and ligase
KXZ66_RS09150	COG0300	oxidoreductase activity
KXZ66_RS09150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS09150	COG3321	synthase
KXZ66_RS09155	COG0300	oxidoreductase activity
KXZ66_RS09155	COG4221	oxidoreductase activity
KXZ66_RS09155	COG3321	synthase
KXZ66_RS09155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KXZ66_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS09160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS09160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KXZ66_RS09160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KXZ66_RS09160	COG3321	synthase
KXZ66_RS09165	COG4221	oxidoreductase activity
KXZ66_RS09165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS09165	COG3321	synthase
KXZ66_RS09165	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS09170	COG3321	synthase
KXZ66_RS09170	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KXZ66_RS09170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KXZ66_RS09170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KXZ66_RS09175	COG2124	cytochrome p450
KXZ66_RS09185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KXZ66_RS09190	COG1404	Belongs to the peptidase S8 family
KXZ66_RS09200	COG4195	phage-related replication protein
KXZ66_RS09205	COG1764	response to oxidative stress
KXZ66_RS09210	COG2076	Multidrug Resistance protein
KXZ66_RS09215	COG2076	Multidrug Resistance protein
KXZ66_RS09230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KXZ66_RS09235	COG1923	regulation of RNA biosynthetic process
KXZ66_RS09250	COG1780	Probably involved in ribonucleotide reductase function
KXZ66_RS09255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KXZ66_RS09260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KXZ66_RS09265	COG4112	unkown
KXZ66_RS09270	COG0860	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS09300	COG2746	aminoglycoside 3-N-acetyltransferase activity
KXZ66_RS09310	COG1525	nuclease
KXZ66_RS09320	COG4282	regulation of fungal-type cell wall biogenesis
KXZ66_RS09325	COG5444	nuclease activity
KXZ66_RS09365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KXZ66_RS09375	COG0457	Tetratricopeptide repeat
KXZ66_RS09390	COG5632	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS09400	COG5434	Belongs to the glycosyl hydrolase 28 family
KXZ66_RS09410	COG2433	Pfam Transposase IS66
KXZ66_RS09420	COG1196	nuclear chromosome segregation
KXZ66_RS09420	COG0741	lytic transglycosylase activity
KXZ66_RS09420	COG0739	heme binding
KXZ66_RS09435	COG0582	viral genome integration into host DNA
KXZ66_RS09560	COG0776	regulation of translation
KXZ66_RS09630	COG3655	Transcriptional regulator
KXZ66_RS09700	COG0582	viral genome integration into host DNA
KXZ66_RS09715	COG3655	Transcriptional regulator
KXZ66_RS09790	COG1793	dna ligase
KXZ66_RS09795	COG2135	peptidase activity
KXZ66_RS09805	COG4195	phage-related replication protein
KXZ66_RS09810	COG3420	alginic acid biosynthetic process
KXZ66_RS09810	COG5434	Belongs to the glycosyl hydrolase 28 family
KXZ66_RS09835	COG2887	Belongs to the helicase family. UvrD subfamily
KXZ66_RS09845	COG0305	Participates in initiation and elongation during chromosome replication
KXZ66_RS09850	COG0358	DNA primase activity
KXZ66_RS09855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KXZ66_RS09860	COG0587	DNA-directed DNA polymerase activity
KXZ66_RS09865	COG3584	3D domain protein
KXZ66_RS09890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KXZ66_RS09895	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
KXZ66_RS09905	COG0270	DNA (cytosine-5-)-methyltransferase activity
KXZ66_RS10000	COG1780	Probably involved in ribonucleotide reductase function
KXZ66_RS10005	COG1372	Participates in initiation and elongation during chromosome replication
KXZ66_RS10005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KXZ66_RS10015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KXZ66_RS10020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS10030	COG0756	dUTP diphosphatase activity
KXZ66_RS10060	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KXZ66_RS10105	COG3331	DNA recombination
KXZ66_RS10125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KXZ66_RS10130	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KXZ66_RS10135	COG0789	Transcriptional regulator
KXZ66_RS10140	COG0174	glutamine synthetase
KXZ66_RS10165	COG4282	regulation of fungal-type cell wall biogenesis
KXZ66_RS10175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KXZ66_RS10205	COG2211	Major facilitator Superfamily
KXZ66_RS10210	COG3507	Belongs to the glycosyl hydrolase 43 family
KXZ66_RS10215	COG1940	carbohydrate kinase activity
KXZ66_RS10220	COG2115	Belongs to the xylose isomerase family
KXZ66_RS10225	COG1070	Carbohydrate kinase
KXZ66_RS10235	COG1525	nuclease
KXZ66_RS10240	COG2814	Major facilitator Superfamily
KXZ66_RS10245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KXZ66_RS10260	COG0756	dUTP diphosphatase activity
KXZ66_RS10300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KXZ66_RS10315	COG3832	glyoxalase III activity
KXZ66_RS10330	COG0697	spore germination
KXZ66_RS10335	COG0531	amino acid
KXZ66_RS10365	COG4195	phage-related replication protein
KXZ66_RS10375	COG0346	lactoylglutathione lyase activity
KXZ66_RS10380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KXZ66_RS10385	COG1388	LysM domain
KXZ66_RS10390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KXZ66_RS10395	COG4224	UPF0291 protein
KXZ66_RS10400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KXZ66_RS10410	COG3763	UPF0154 protein
KXZ66_RS10420	COG0785	Cytochrome C biogenesis protein
KXZ66_RS10425	COG2201	protein-glutamate methylesterase activity
KXZ66_RS10430	COG4846	Membrane protein involved in cytochrome C biogenesis
KXZ66_RS10440	COG0071	Belongs to the small heat shock protein (HSP20) family
KXZ66_RS10455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KXZ66_RS10460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS10480	COG0824	Thioesterase
KXZ66_RS10490	COG4841	protein insertion into membrane
KXZ66_RS10495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KXZ66_RS10500	COG1832	CoA-binding protein
KXZ66_RS10505	COG0187	DNA topoisomerase II activity
KXZ66_RS10510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KXZ66_RS10520	COG1115	amino acid carrier protein
KXZ66_RS10525	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KXZ66_RS10535	COG5520	Belongs to the glycosyl hydrolase 30 family
KXZ66_RS10540	COG3507	Belongs to the glycosyl hydrolase 43 family
KXZ66_RS10545	COG2246	polysaccharide biosynthetic process
KXZ66_RS10550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KXZ66_RS10555	COG0586	Pfam SNARE associated Golgi protein
KXZ66_RS10560	COG2404	hydrolase activity, acting on ester bonds
KXZ66_RS10565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KXZ66_RS10570	COG1024	Enoyl-CoA hydratase
KXZ66_RS10575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KXZ66_RS10580	COG0511	ligase activity, forming carbon-carbon bonds
KXZ66_RS10585	COG0439	Biotin carboxylase
KXZ66_RS10590	COG0318	PFAM AMP-dependent synthetase and ligase
KXZ66_RS10595	COG1960	acyl-CoA dehydrogenase activity
KXZ66_RS10610	COG1649	PFAM Uncharacterised BCR, COG1649
KXZ66_RS10620	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KXZ66_RS10620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS10625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS10630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS10635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS10640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS10645	COG2027	D-alanyl-D-alanine carboxypeptidase
KXZ66_RS10650	COG2017	converts alpha-aldose to the beta-anomer
KXZ66_RS10655	COG0534	Mate efflux family protein
KXZ66_RS10670	COG0582	viral genome integration into host DNA
KXZ66_RS10675	COG0166	Belongs to the GPI family
KXZ66_RS10680	COG0405	Gamma-glutamyltransferase
KXZ66_RS10685	COG0583	DNA-binding transcription factor activity
KXZ66_RS10690	COG0604	alcohol dehydrogenase
KXZ66_RS10695	COG0493	'glutamate synthase
KXZ66_RS10700	COG0070	glutamate synthase
KXZ66_RS10700	COG0069	glutamate synthase activity
KXZ66_RS10700	COG0067	glutamate synthase
KXZ66_RS10705	COG0583	DNA-binding transcription factor activity
KXZ66_RS10710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KXZ66_RS10715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KXZ66_RS10725	COG0300	oxidoreductase activity
KXZ66_RS10730	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KXZ66_RS10740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KXZ66_RS10755	COG1131	(ABC) transporter
KXZ66_RS10765	COG2814	Major facilitator Superfamily
KXZ66_RS10770	COG1070	Carbohydrate kinase
KXZ66_RS10775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KXZ66_RS10780	COG0243	molybdopterin cofactor binding
KXZ66_RS10790	COG2814	Major facilitator Superfamily
KXZ66_RS10795	COG0673	inositol 2-dehydrogenase activity
KXZ66_RS10800	COG1082	Xylose isomerase domain protein TIM barrel
KXZ66_RS10805	COG1609	Transcriptional regulator
KXZ66_RS10825	COG5278	phosphoserine phosphatase activity
KXZ66_RS10825	COG0840	transmembrane signaling receptor activity
KXZ66_RS10830	COG2368	4-hydroxyphenylacetate
KXZ66_RS10835	COG4305	rare lipoprotein A
KXZ66_RS10840	COG3619	membrane
KXZ66_RS10845	COG3866	Pectate lyase
KXZ66_RS10850	COG2135	peptidase activity
KXZ66_RS10860	COG2140	Oxalate decarboxylase
KXZ66_RS10885	COG2720	vancomycin resistance protein
KXZ66_RS10900	COG3739	integral membrane protein
KXZ66_RS10905	COG0583	DNA-binding transcription factor activity
KXZ66_RS10910	COG0697	spore germination
KXZ66_RS10920	COG0693	protein deglycase activity
KXZ66_RS10925	COG2367	Beta-lactamase
KXZ66_RS10945	COG0574	Belongs to the PEP-utilizing enzyme family
KXZ66_RS10945	COG3848	Pyruvate phosphate dikinase
KXZ66_RS10950	COG0726	polysaccharide deacetylase
KXZ66_RS10995	COG4282	regulation of fungal-type cell wall biogenesis
KXZ66_RS11000	COG1231	oxidoreductase activity
KXZ66_RS11005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KXZ66_RS11010	COG2207	Transcriptional regulator
KXZ66_RS11010	COG0662	Cupin 2, conserved barrel domain protein
KXZ66_RS11015	COG0456	acetyltransferase
KXZ66_RS11020	COG1309	transcriptional regulator
KXZ66_RS11025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KXZ66_RS11030	COG3708	Transcriptional regulator
KXZ66_RS11035	COG2378	regulation of single-species biofilm formation
KXZ66_RS11045	COG0640	Transcriptional regulator
KXZ66_RS11050	COG0741	lytic transglycosylase activity
KXZ66_RS11055	COG2322	membrane
KXZ66_RS11070	COG1619	proteins homologs of microcin C7 resistance protein MccF
KXZ66_RS11075	COG3239	Fatty acid desaturase
KXZ66_RS11080	COG4585	Histidine kinase
KXZ66_RS11085	COG2197	response regulator
KXZ66_RS11090	COG3584	3D domain protein
KXZ66_RS11090	COG1388	LysM domain
KXZ66_RS11095	COG0514	ATP-dependent DNA helicase (RecQ)
KXZ66_RS11105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KXZ66_RS11110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KXZ66_RS11125	COG0071	Belongs to the small heat shock protein (HSP20) family
KXZ66_RS11150	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS11155	COG1657	PFAM Prenyltransferase squalene oxidase
KXZ66_RS11160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KXZ66_RS11165	COG0733	neurotransmitter:sodium symporter activity
KXZ66_RS11170	COG0385	Bile acid
KXZ66_RS11175	COG0508	dehydrogenase complex catalyzes the overall conversion of
KXZ66_RS11180	COG0567	Dehydrogenase, E1 component
KXZ66_RS11185	COG4548	von Willebrand factor, type A
KXZ66_RS11190	COG0714	Associated with various cellular activities
KXZ66_RS11195	COG2032	superoxide dismutase activity
KXZ66_RS11200	COG0791	NLP P60 protein
KXZ66_RS11200	COG1388	LysM domain
KXZ66_RS11205	COG1819	glycosyl
KXZ66_RS11210	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KXZ66_RS11215	COG0534	Mate efflux family protein
KXZ66_RS11220	COG1366	Belongs to the anti-sigma-factor antagonist family
KXZ66_RS11225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KXZ66_RS11230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KXZ66_RS11240	COG2962	Rard protein
KXZ66_RS11260	COG1942	4-Oxalocrotonate Tautomerase
KXZ66_RS11265	COG1733	regulation of RNA biosynthetic process
KXZ66_RS11270	COG0778	Nitroreductase
KXZ66_RS11275	COG0400	carboxylic ester hydrolase activity
KXZ66_RS11280	COG0346	lactoylglutathione lyase activity
KXZ66_RS11290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KXZ66_RS11295	COG3409	Peptidoglycan-binding domain 1 protein
KXZ66_RS11295	COG0793	Belongs to the peptidase S41A family
KXZ66_RS11300	COG2226	methyltransferase
KXZ66_RS11310	COG1876	peptidase activity
KXZ66_RS11315	COG0813	purine-nucleoside phosphorylase activity
KXZ66_RS11330	COG0671	phosphoesterase, PA-phosphatase related
KXZ66_RS11350	COG4479	Belongs to the UPF0346 family
KXZ66_RS11360	COG1509	lysine 2,3-aminomutase activity
KXZ66_RS11365	COG0456	acetyltransferase
KXZ66_RS11370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KXZ66_RS11375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KXZ66_RS11380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KXZ66_RS11385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KXZ66_RS11400	COG0456	acetyltransferase
KXZ66_RS11405	COG0463	Glycosyl transferase, family 2
KXZ66_RS11420	COG4641	Protein conserved in bacteria
KXZ66_RS11425	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
KXZ66_RS11430	COG1086	Polysaccharide biosynthesis protein
KXZ66_RS11435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KXZ66_RS11440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KXZ66_RS11445	COG1846	Transcriptional regulator
KXZ66_RS11450	COG0534	Mate efflux family protein
KXZ66_RS11460	COG4698	Protein conserved in bacteria
KXZ66_RS11465	COG2755	lipolytic protein G-D-S-L family
KXZ66_RS11470	COG1999	signal sequence binding
KXZ66_RS11480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KXZ66_RS11485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KXZ66_RS11490	COG1272	protein, Hemolysin III
KXZ66_RS11495	COG0204	Acyl-transferase
KXZ66_RS11500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KXZ66_RS11505	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KXZ66_RS11515	COG2136	Putative SAM-dependent methyltransferase
KXZ66_RS11515	COG2521	methyltransferase
KXZ66_RS11525	COG0129	dihydroxy-acid dehydratase activity
KXZ66_RS11530	COG1413	lyase activity
KXZ66_RS11535	COG1418	mRNA catabolic process
KXZ66_RS11540	COG0386	Belongs to the glutathione peroxidase family
KXZ66_RS11545	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KXZ66_RS11550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KXZ66_RS11560	COG1278	Cold shock
KXZ66_RS11580	COG0328	RNA-DNA hybrid ribonuclease activity
KXZ66_RS11585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KXZ66_RS11590	COG0328	RNA-DNA hybrid ribonuclease activity
KXZ66_RS11600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KXZ66_RS11615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KXZ66_RS11625	COG1755	Isoprenylcysteine carboxyl methyltransferase
KXZ66_RS11630	COG3424	synthase
KXZ66_RS11635	COG2233	PERMEase
KXZ66_RS11640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KXZ66_RS11645	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KXZ66_RS11655	COG0800	Aldolase
KXZ66_RS11660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KXZ66_RS11665	COG1609	Transcriptional regulator
KXZ66_RS11670	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KXZ66_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS11680	COG1199	ATP-dependent helicase activity
KXZ66_RS11695	COG0116	Belongs to the methyltransferase superfamily
KXZ66_RS11710	COG4474	Belongs to the UPF0398 family
KXZ66_RS11725	COG3359	exonuclease
KXZ66_RS11730	COG1111	helicase
KXZ66_RS11730	COG1205	dead DEAH box helicase
KXZ66_RS11735	COG2190	(PTS) system
KXZ66_RS11740	COG0071	Belongs to the small heat shock protein (HSP20) family
KXZ66_RS11775	COG3331	DNA recombination
KXZ66_RS11780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KXZ66_RS11780	COG4499	WXG100 protein secretion system (Wss), protein YukC
KXZ66_RS11790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KXZ66_RS11795	COG3935	DnaD domain protein
KXZ66_RS11800	COG0017	Asparaginyl-tRNA synthetase
KXZ66_RS11805	COG0436	Aminotransferase
KXZ66_RS11810	COG5353	protein conserved in bacteria
KXZ66_RS11820	COG1199	ATP-dependent helicase activity
KXZ66_RS11820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KXZ66_RS11825	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KXZ66_RS11830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KXZ66_RS11835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KXZ66_RS11840	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KXZ66_RS11840	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KXZ66_RS11845	COG0617	tRNA 3'-terminal CCA addition
KXZ66_RS11850	COG0438	transferase activity, transferring glycosyl groups
KXZ66_RS11855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KXZ66_RS11860	COG1803	Methylglyoxal synthase
KXZ66_RS11865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KXZ66_RS11870	COG1694	Mazg nucleotide pyrophosphohydrolase
KXZ66_RS11875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KXZ66_RS11885	COG4347	Protein of unknown function (DUF1405)
KXZ66_RS11890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KXZ66_RS11890	COG2010	Cytochrome c
KXZ66_RS11895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KXZ66_RS11900	COG0723	plastoquinol--plastocyanin reductase activity
KXZ66_RS11910	COG5582	Belongs to the UPF0302 family
KXZ66_RS11915	COG0457	Tetratricopeptide repeat
KXZ66_RS11920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KXZ66_RS11925	COG0287	Prephenate dehydrogenase
KXZ66_RS11935	COG0159	tryptophan synthase activity
KXZ66_RS11940	COG0133	tryptophan synthase activity
KXZ66_RS11945	COG0135	phosphoribosylanthranilate isomerase activity
KXZ66_RS11955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KXZ66_RS11960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KXZ66_RS11965	COG4401	Chorismate mutase type I
KXZ66_RS11970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KXZ66_RS11975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KXZ66_RS11980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KXZ66_RS11985	COG0105	UTP biosynthetic process
KXZ66_RS11990	COG0142	geranyltranstransferase activity
KXZ66_RS11995	COG2226	methyltransferase
KXZ66_RS12000	COG0142	geranyltranstransferase activity
KXZ66_RS12010	COG0302	gtp cyclohydrolase
KXZ66_RS12015	COG0776	regulation of translation
KXZ66_RS12020	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KXZ66_RS12035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KXZ66_RS12040	COG1160	GTP binding
KXZ66_RS12065	COG1304	FMN binding
KXZ66_RS12070	COG0539	negative regulation of cytoplasmic translation
KXZ66_RS12075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KXZ66_RS12085	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
KXZ66_RS12090	COG2959	enzyme of heme biosynthesis
KXZ66_RS12095	COG3409	Peptidoglycan-binding domain 1 protein
KXZ66_RS12095	COG3773	Cell wall hydrolase
KXZ66_RS12100	COG2339	peptidase activity
KXZ66_RS12105	COG0492	ferredoxin-NADP+ reductase activity
KXZ66_RS12110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KXZ66_RS12115	COG4862	establishment of competence for transformation
KXZ66_RS12120	COG1408	metallophosphoesterase
KXZ66_RS12130	COG1388	LysM domain
KXZ66_RS12135	COG1266	CAAX protease self-immunity
KXZ66_RS12140	COG0514	ATP-dependent DNA helicase (RecQ)
KXZ66_RS12145	COG4955	Helix-turn-helix domain
KXZ66_RS12150	COG1141	Ferredoxin
KXZ66_RS12155	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KXZ66_RS12160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KXZ66_RS12165	COG0710	3-dehydroquinate dehydratase activity
KXZ66_RS12175	COG1595	DNA-templated transcription, initiation
KXZ66_RS12180	COG5002	protein histidine kinase activity
KXZ66_RS12185	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS12190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KXZ66_RS12195	COG1333	cytochrome c biogenesis protein
KXZ66_RS12200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS12205	COG1187	pseudouridine synthase activity
KXZ66_RS12210	COG0700	Nucleoside recognition
KXZ66_RS12215	COG2715	membrane protein required for spore maturation
KXZ66_RS12220	COG1686	Belongs to the peptidase S11 family
KXZ66_RS12230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KXZ66_RS12235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KXZ66_RS12240	COG1547	Domain of unknown function (DUF309)
KXZ66_RS12245	COG0456	acetyltransferase
KXZ66_RS12250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KXZ66_RS12255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KXZ66_RS12255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KXZ66_RS12260	COG0307	riboflavin synthase, alpha
KXZ66_RS12265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KXZ66_RS12265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KXZ66_RS12275	COG0681	Belongs to the peptidase S26 family
KXZ66_RS12285	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
KXZ66_RS12295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KXZ66_RS12300	COG4086	secreted protein
KXZ66_RS12305	COG0019	diaminopimelate decarboxylase activity
KXZ66_RS12310	COG0697	spore germination
KXZ66_RS12325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KXZ66_RS12345	COG1191	sigma factor activity
KXZ66_RS12350	COG2172	sigma factor antagonist activity
KXZ66_RS12355	COG1366	Belongs to the anti-sigma-factor antagonist family
KXZ66_RS12360	COG1686	Belongs to the peptidase S11 family
KXZ66_RS12365	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KXZ66_RS12370	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KXZ66_RS12375	COG4974	Belongs to the 'phage' integrase family
KXZ66_RS12385	COG0735	belongs to the Fur family
KXZ66_RS12390	COG1300	Membrane
KXZ66_RS12400	COG0281	malic enzyme
KXZ66_RS12405	COG1757	Na H antiporter
KXZ66_RS12410	COG1027	Aspartate ammonia-lyase
KXZ66_RS12415	COG0252	asparaginase activity
KXZ66_RS12420	COG1396	sequence-specific DNA binding
KXZ66_RS12425	COG1379	DNA repair
KXZ66_RS12430	COG0494	nUDIX hydrolase
KXZ66_RS12440	COG0667	Aldo Keto reductase
KXZ66_RS12450	COG1073	alpha beta
KXZ66_RS12460	COG4918	Iron-sulphur cluster biosynthesis
KXZ66_RS12465	COG0456	acetyltransferase
KXZ66_RS12465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KXZ66_RS12470	COG2329	Antibiotic biosynthesis monooxygenase
KXZ66_RS12475	COG0456	acetyltransferase
KXZ66_RS12485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KXZ66_RS12495	COG2211	Major facilitator Superfamily
KXZ66_RS12505	COG0346	lactoylglutathione lyase activity
KXZ66_RS12510	COG1072	(Pantothenic acid kinase))
KXZ66_RS12515	COG3048	D-serine ammonia-lyase activity
KXZ66_RS12520	COG0300	oxidoreductase activity
KXZ66_RS12525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KXZ66_RS12530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KXZ66_RS12535	COG4187	Peptidase family M20/M25/M40
KXZ66_RS12540	COG1902	pentaerythritol trinitrate reductase activity
KXZ66_RS12545	COG0596	Alpha beta hydrolase
KXZ66_RS12555	COG1234	tRNA 3'-trailer cleavage
KXZ66_RS12560	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KXZ66_RS12565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KXZ66_RS12570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KXZ66_RS12580	COG0706	membrane insertase activity
KXZ66_RS12585	COG3361	conserved protein (COG2071)
KXZ66_RS12590	COG2195	Cleaves the N-terminal amino acid of tripeptides
KXZ66_RS12595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KXZ66_RS12600	COG0346	lactoylglutathione lyase activity
KXZ66_RS12610	COG1376	ErfK ybiS ycfS ynhG family protein
KXZ66_RS12615	COG4129	membrane
KXZ66_RS12620	COG1126	abc transporter atp-binding protein
KXZ66_RS12625	COG0765	amino acid transport
KXZ66_RS12630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KXZ66_RS12640	COG1597	lipid kinase activity
KXZ66_RS12645	COG2814	Major facilitator Superfamily
KXZ66_RS12650	COG4978	Transcriptional regulator
KXZ66_RS12650	COG0789	Transcriptional regulator
KXZ66_RS12655	COG0508	dehydrogenase complex catalyzes the overall conversion of
KXZ66_RS12660	COG0022	dehydrogenase e1 component
KXZ66_RS12665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KXZ66_RS12670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KXZ66_RS12675	COG3426	butyrate kinase activity
KXZ66_RS12680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KXZ66_RS12685	COG0280	phosphate acetyltransferase
KXZ66_RS12690	COG3290	protein histidine kinase activity
KXZ66_RS12690	COG3829	transcription factor binding
KXZ66_RS12700	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KXZ66_RS12705	COG2079	MmgE PrpD family protein
KXZ66_RS12710	COG0372	Belongs to the citrate synthase family
KXZ66_RS12715	COG1960	acyl-CoA dehydrogenase activity
KXZ66_RS12720	COG1250	3-hydroxyacyl-CoA dehydrogenase
KXZ66_RS12725	COG0183	Belongs to the thiolase family
KXZ66_RS12730	COG0584	glycerophosphoryl diester phosphodiesterase
KXZ66_RS12735	COG0860	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS12750	COG1902	pentaerythritol trinitrate reductase activity
KXZ66_RS12755	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS12760	COG0750	zinc metalloprotease
KXZ66_RS12765	COG0497	DNA recombination
KXZ66_RS12770	COG1438	arginine binding
KXZ66_RS12775	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KXZ66_RS12780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KXZ66_RS12785	COG0142	geranyltranstransferase activity
KXZ66_RS12790	COG1722	exodeoxyribonuclease VII activity
KXZ66_RS12795	COG1570	exodeoxyribonuclease VII activity
KXZ66_RS12800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KXZ66_RS12805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KXZ66_RS12810	COG1302	Protein conserved in bacteria
KXZ66_RS12815	COG0439	Biotin carboxylase
KXZ66_RS12820	COG0511	ligase activity, forming carbon-carbon bonds
KXZ66_RS12860	COG3854	ATPases associated with a variety of cellular activities
KXZ66_RS12870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KXZ66_RS12875	COG0006	proline dipeptidase activity
KXZ66_RS12880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KXZ66_RS12890	COG3872	metal-dependent enzyme
KXZ66_RS12900	COG1752	Esterase of the alpha-beta hydrolase superfamily
KXZ66_RS12905	COG1321	iron dependent repressor
KXZ66_RS12910	COG0095	Lipoate-protein ligase
KXZ66_RS12915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KXZ66_RS12920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KXZ66_RS12925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KXZ66_RS12930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KXZ66_RS12935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KXZ66_RS12950	COG1396	sequence-specific DNA binding
KXZ66_RS12960	COG0681	Belongs to the peptidase S26 family
KXZ66_RS12985	COG4940	Competence protein ComGF
KXZ66_RS12995	COG4970	Tfp pilus assembly protein FimT
KXZ66_RS13000	COG4537	Required for transformation and DNA binding
KXZ66_RS13005	COG1459	type II secretion system
KXZ66_RS13010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KXZ66_RS13020	COG0598	Magnesium transport protein CorA
KXZ66_RS13025	COG1253	flavin adenine dinucleotide binding
KXZ66_RS13030	COG1366	Belongs to the anti-sigma-factor antagonist family
KXZ66_RS13040	COG1393	Belongs to the ArsC family
KXZ66_RS13050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KXZ66_RS13060	COG0011	TIGRFAM Protein of
KXZ66_RS13070	COG2866	Carboxypeptidase
KXZ66_RS13075	COG1368	sulfuric ester hydrolase activity
KXZ66_RS13080	COG1940	carbohydrate kinase activity
KXZ66_RS13085	COG4483	Protein conserved in bacteria
KXZ66_RS13090	COG0457	Tetratricopeptide repeat
KXZ66_RS13090	COG0705	Rhomboid family
KXZ66_RS13100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KXZ66_RS13110	COG0438	transferase activity, transferring glycosyl groups
KXZ66_RS13125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KXZ66_RS13130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KXZ66_RS13135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KXZ66_RS13140	COG0581	inorganic phosphate transmembrane transporter activity
KXZ66_RS13145	COG0573	inorganic phosphate transmembrane transporter activity
KXZ66_RS13150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KXZ66_RS13155	COG0768	penicillin binding
KXZ66_RS13160	COG0477	Major facilitator Superfamily
KXZ66_RS13165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KXZ66_RS13170	COG2839	Protein conserved in bacteria
KXZ66_RS13175	COG5521	maltodextrose utilization protein MalA
KXZ66_RS13180	COG1388	LysM domain
KXZ66_RS13185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KXZ66_RS13190	COG4709	membrane
KXZ66_RS13195	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
KXZ66_RS13200	COG0735	belongs to the Fur family
KXZ66_RS13205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KXZ66_RS13215	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KXZ66_RS13220	COG0513	Belongs to the DEAD box helicase family
KXZ66_RS13230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KXZ66_RS13235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KXZ66_RS13240	COG2384	SAM-dependent methyltransferase
KXZ66_RS13245	COG2010	Cytochrome c
KXZ66_RS13250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KXZ66_RS13255	COG0358	DNA primase activity
KXZ66_RS13260	COG1671	Belongs to the UPF0178 family
KXZ66_RS13265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KXZ66_RS13270	COG0517	IMP dehydrogenase activity
KXZ66_RS13275	COG0751	glycine-tRNA ligase activity
KXZ66_RS13280	COG0752	glycyl-tRNA synthetase alpha subunit
KXZ66_RS13285	COG1381	Involved in DNA repair and RecF pathway recombination
KXZ66_RS13295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KXZ66_RS13300	COG0295	cytidine deaminase activity
KXZ66_RS13305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KXZ66_RS13310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KXZ66_RS13315	COG1480	7TM receptor with intracellular HD hydrolase
KXZ66_RS13320	COG1702	phosphate starvation-inducible protein PhoH
KXZ66_RS13325	COG0561	phosphatase activity
KXZ66_RS13340	COG4864	UPF0365 protein
KXZ66_RS13345	COG1030	water channel activity
KXZ66_RS13350	COG1610	YqeY-like protein
KXZ66_RS13360	COG1283	sodium-dependent phosphate transmembrane transporter activity
KXZ66_RS13365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KXZ66_RS13370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KXZ66_RS13375	COG2264	protein methyltransferase activity
KXZ66_RS13380	COG0484	heat shock protein binding
KXZ66_RS13385	COG0443	Heat shock 70 kDa protein
KXZ66_RS13390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KXZ66_RS13395	COG1420	regulation of RNA biosynthetic process
KXZ66_RS13400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KXZ66_RS13405	COG0481	GTPase activity
KXZ66_RS13415	COG0860	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS13420	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KXZ66_RS13425	COG0268	Binds directly to 16S ribosomal RNA
KXZ66_RS13430	COG1466	dna polymerase III delta subunit
KXZ66_RS13445	COG0658	competence protein
KXZ66_RS13445	COG2333	competence protein COMEC
KXZ66_RS13450	COG2131	deaminase
KXZ66_RS13455	COG1555	photosystem II stabilization
KXZ66_RS13455	COG1596	polysaccharide export
KXZ66_RS13460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KXZ66_RS13465	COG2226	methyltransferase
KXZ66_RS13470	COG0799	negative regulation of ribosome biogenesis
KXZ66_RS13475	COG1713	HD superfamily hydrolase involved in NAD metabolism
KXZ66_RS13480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KXZ66_RS13485	COG1534	Rna-binding protein
KXZ66_RS13490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KXZ66_RS13495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KXZ66_RS13500	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KXZ66_RS13510	COG2755	lipolytic protein G-D-S-L family
KXZ66_RS13515	COG3409	Peptidoglycan-binding domain 1 protein
KXZ66_RS13515	COG5632	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS13520	COG0398	Pfam SNARE associated Golgi protein
KXZ66_RS13525	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KXZ66_RS13535	COG3209	COG3209 Rhs family protein
KXZ66_RS13555	COG3223	Belongs to the PsiE family
KXZ66_RS13560	COG0642	Histidine kinase
KXZ66_RS13560	COG5002	protein histidine kinase activity
KXZ66_RS13565	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS13570	COG2311	Membrane
KXZ66_RS13580	COG0454	-acetyltransferase
KXZ66_RS13585	COG2249	NAD(P)H dehydrogenase (quinone) activity
KXZ66_RS13595	COG0730	response to heat
KXZ66_RS13600	COG0425	Belongs to the sulfur carrier protein TusA family
KXZ66_RS13615	COG0425	Belongs to the sulfur carrier protein TusA family
KXZ66_RS13615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KXZ66_RS13620	COG2210	Belongs to the sulfur carrier protein TusA family
KXZ66_RS13625	COG1937	Protein conserved in bacteria
KXZ66_RS13630	COG0662	Cupin 2, conserved barrel domain protein
KXZ66_RS13640	COG0789	Transcriptional regulator
KXZ66_RS13640	COG4978	Transcriptional regulator
KXZ66_RS13645	COG2814	Major facilitator Superfamily
KXZ66_RS13650	COG0456	acetyltransferase
KXZ66_RS13655	COG1253	flavin adenine dinucleotide binding
KXZ66_RS13665	COG0697	spore germination
KXZ66_RS13670	COG0583	DNA-binding transcription factor activity
KXZ66_RS13675	COG2072	flavoprotein involved in K transport
KXZ66_RS13680	COG1230	cation diffusion facilitator family transporter
KXZ66_RS13690	COG1114	Component of the transport system for branched-chain amino acids
KXZ66_RS13695	COG1687	branched-chain amino acid
KXZ66_RS13700	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KXZ66_RS13705	COG1522	sequence-specific DNA binding
KXZ66_RS13710	COG2732	(Barnase) inhibitor
KXZ66_RS13715	COG2124	cytochrome p450
KXZ66_RS13725	COG1335	isochorismatase
KXZ66_RS13745	COG2318	DinB family
KXZ66_RS13755	COG2070	2-Nitropropane dioxygenase
KXZ66_RS13760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KXZ66_RS13770	COG2186	Transcriptional regulator
KXZ66_RS13785	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS13790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KXZ66_RS13795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KXZ66_RS13800	COG0477	Major facilitator Superfamily
KXZ66_RS13805	COG1846	Transcriptional regulator
KXZ66_RS13810	COG3443	Belongs to the bacterial solute-binding protein 9 family
KXZ66_RS13815	COG1595	DNA-templated transcription, initiation
KXZ66_RS13820	COG0667	Aldo Keto reductase
KXZ66_RS13825	COG2851	Citrate transporter
KXZ66_RS13830	COG0583	DNA-binding transcription factor activity
KXZ66_RS13835	COG2828	Protein conserved in bacteria
KXZ66_RS13840	COG3409	Peptidoglycan-binding domain 1 protein
KXZ66_RS13845	COG5566	PFAM Mor transcription activator
KXZ66_RS13850	COG0596	Alpha beta hydrolase
KXZ66_RS13855	COG4991	sh3 domain protein
KXZ66_RS13860	COG4991	sh3 domain protein
KXZ66_RS13870	COG0346	lactoylglutathione lyase activity
KXZ66_RS13880	COG5577	PFAM Coat F domain
KXZ66_RS13885	COG1063	alcohol dehydrogenase
KXZ66_RS13895	COG5577	PFAM Coat F domain
KXZ66_RS13900	COG0789	Transcriptional regulator
KXZ66_RS13910	COG1064	alcohol dehydrogenase
KXZ66_RS13915	COG0693	protein deglycase activity
KXZ66_RS13920	COG1621	beta-fructofuranosidase activity
KXZ66_RS13925	COG3716	PTS system mannose fructose sorbose family IID component
KXZ66_RS13930	COG3715	PTS system
KXZ66_RS13935	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS13940	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KXZ66_RS13945	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KXZ66_RS13945	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KXZ66_RS13955	COG1113	amino acid transport
KXZ66_RS13960	COG1280	lysine exporter protein (LysE YggA)
KXZ66_RS13965	COG1378	Sugar-specific transcriptional regulator TrmB
KXZ66_RS13970	COG1595	DNA-templated transcription, initiation
KXZ66_RS13980	COG2755	lipolytic protein G-D-S-L family
KXZ66_RS13980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KXZ66_RS13990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KXZ66_RS13990	COG2124	cytochrome p450
KXZ66_RS13995	COG1309	transcriptional regulator
KXZ66_RS14000	COG2226	methyltransferase
KXZ66_RS14015	COG2116	formate transmembrane transporter activity
KXZ66_RS14020	COG5609	conserved protein (DUF2294)
KXZ66_RS14025	COG3383	formate dehydrogenase (NAD+) activity
KXZ66_RS14030	COG2427	Protein of unknown function (DUF1641)
KXZ66_RS14040	COG0626	cystathionine gamma-synthase activity
KXZ66_RS14045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KXZ66_RS14050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KXZ66_RS14055	COG2226	methyltransferase
KXZ66_RS14070	COG0768	penicillin binding
KXZ66_RS14075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KXZ66_RS14080	COG0572	uridine kinase
KXZ66_RS14085	COG0826	peptidase U32
KXZ66_RS14090	COG0826	peptidase U32
KXZ66_RS14095	COG4122	O-methyltransferase activity
KXZ66_RS14100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KXZ66_RS14105	COG3906	Belongs to the UPF0473 family
KXZ66_RS14110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KXZ66_RS14115	COG4472	Bacterial protein of unknown function (DUF965)
KXZ66_RS14120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KXZ66_RS14125	COG0628	permease
KXZ66_RS14130	COG1126	abc transporter atp-binding protein
KXZ66_RS14135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KXZ66_RS14140	COG0765	amino acid transport
KXZ66_RS14145	COG0765	amino acid transport
KXZ66_RS14160	COG3881	PFAM PRC-barrel domain
KXZ66_RS14165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KXZ66_RS14170	COG0457	Tetratricopeptide repeat
KXZ66_RS14175	COG0482	sulfurtransferase activity
KXZ66_RS14180	COG1104	cysteine desulfurase activity
KXZ66_RS14185	COG1959	2 iron, 2 sulfur cluster binding
KXZ66_RS14190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KXZ66_RS14195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KXZ66_RS14205	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KXZ66_RS14210	COG0124	histidyl-tRNA synthetase
KXZ66_RS14220	COG0860	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS14220	COG3103	Sh3 type 3 domain protein
KXZ66_RS14220	COG4991	sh3 domain protein
KXZ66_RS14225	COG1490	D-aminoacyl-tRNA deacylase activity
KXZ66_RS14230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KXZ66_RS14235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KXZ66_RS14240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KXZ66_RS14240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KXZ66_RS14245	COG5416	Lipopolysaccharide assembly protein A domain
KXZ66_RS14250	COG0490	domain, Protein
KXZ66_RS14255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KXZ66_RS14255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KXZ66_RS14265	COG2244	polysaccharide biosynthetic process
KXZ66_RS14270	COG2323	membrane
KXZ66_RS14280	COG1862	Preprotein translocase
KXZ66_RS14285	COG0343	queuine tRNA-ribosyltransferase activity
KXZ66_RS14290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KXZ66_RS14300	COG2255	four-way junction helicase activity
KXZ66_RS14305	COG0632	four-way junction helicase activity
KXZ66_RS14315	COG2814	Major facilitator Superfamily
KXZ66_RS14320	COG0673	inositol 2-dehydrogenase activity
KXZ66_RS14325	COG2112	serine threonine protein kinase
KXZ66_RS14345	COG1115	amino acid carrier protein
KXZ66_RS14350	COG0217	transcriptional regulatory protein
KXZ66_RS14360	COG1388	LysM domain
KXZ66_RS14365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KXZ66_RS14370	COG0157	Belongs to the NadC ModD family
KXZ66_RS14375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KXZ66_RS14380	COG1104	cysteine desulfurase activity
KXZ66_RS14385	COG1827	regulation of RNA biosynthetic process
KXZ66_RS14390	COG0077	Prephenate dehydratase
KXZ66_RS14395	COG4492	Belongs to the UPF0735 family
KXZ66_RS14400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KXZ66_RS14405	COG3290	protein histidine kinase activity
KXZ66_RS14415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KXZ66_RS14420	COG2868	ribosomal protein
KXZ66_RS14425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KXZ66_RS14430	COG1994	Peptidase M50
KXZ66_RS14435	COG0739	heme binding
KXZ66_RS14440	COG2894	cell division
KXZ66_RS14445	COG0850	regulation of cytokinetic process
KXZ66_RS14450	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KXZ66_RS14460	COG1077	Cell shape determining protein MreB Mrl
KXZ66_RS14465	COG2003	Belongs to the UPF0758 family
KXZ66_RS14470	COG0424	maF-like protein
KXZ66_RS14480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KXZ66_RS14485	COG0285	dihydrofolate synthase activity
KXZ66_RS14490	COG0525	valine-tRNA ligase activity
KXZ66_RS14500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KXZ66_RS14505	COG1388	LysM domain
KXZ66_RS14510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KXZ66_RS14515	COG0113	porphobilinogen synthase activity
KXZ66_RS14520	COG1587	Uroporphyrinogen-III synthase
KXZ66_RS14525	COG0181	hydroxymethylbilane synthase activity
KXZ66_RS14530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KXZ66_RS14535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KXZ66_RS14545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KXZ66_RS14550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KXZ66_RS14555	COG0470	DNA polymerase III
KXZ66_RS14555	COG1067	ATP-dependent peptidase activity
KXZ66_RS14560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KXZ66_RS14565	COG0544	peptidyl-prolyl cis-trans isomerase activity
KXZ66_RS14570	COG0457	Tetratricopeptide repeat
KXZ66_RS14570	COG1477	protein flavinylation
KXZ66_RS14575	COG0066	3-isopropylmalate dehydratase activity
KXZ66_RS14580	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KXZ66_RS14585	COG0473	3-isopropylmalate dehydrogenase activity
KXZ66_RS14590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KXZ66_RS14595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KXZ66_RS14600	COG0440	acetolactate synthase activity
KXZ66_RS14605	COG0028	Belongs to the TPP enzyme family
KXZ66_RS14615	COG0454	-acetyltransferase
KXZ66_RS14620	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
KXZ66_RS14630	COG0622	Phosphoesterase
KXZ66_RS14635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KXZ66_RS14640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KXZ66_RS14645	COG5401	PFAM Sporulation and spore germination
KXZ66_RS14650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KXZ66_RS14655	COG1846	Transcriptional regulator
KXZ66_RS14660	COG2197	response regulator
KXZ66_RS14665	COG0824	Thioesterase
KXZ66_RS14670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KXZ66_RS14675	COG1053	succinate dehydrogenase
KXZ66_RS14680	COG2009	succinate dehydrogenase
KXZ66_RS14685	COG1719	4-vinyl reductase, 4VR
KXZ66_RS14690	COG0527	aspartate kinase activity
KXZ66_RS14695	COG0322	excinuclease ABC activity
KXZ66_RS14700	COG3118	belongs to the thioredoxin family
KXZ66_RS14705	COG3534	alpha-L-arabinofuranosidase
KXZ66_RS14710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KXZ66_RS14715	COG2086	electron transfer activity
KXZ66_RS14720	COG1024	Enoyl-CoA hydratase
KXZ66_RS14725	COG1309	transcriptional regulator
KXZ66_RS14730	COG0318	PFAM AMP-dependent synthetase and ligase
KXZ66_RS14735	COG3766	membrane
KXZ66_RS14740	COG1193	negative regulation of DNA recombination
KXZ66_RS14745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KXZ66_RS14745	COG1796	DNA polymerase
KXZ66_RS14750	COG1286	toxin biosynthetic process
KXZ66_RS14755	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KXZ66_RS14760	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KXZ66_RS14765	COG0072	phenylalanine-tRNA ligase activity
KXZ66_RS14765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KXZ66_RS14770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KXZ66_RS14780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KXZ66_RS14790	COG3835	regulator
KXZ66_RS14795	COG0277	FAD linked oxidase domain protein
KXZ66_RS14800	COG0247	lactate metabolic process
KXZ66_RS14805	COG0346	lactoylglutathione lyase activity
KXZ66_RS14810	COG1966	Carbon starvation protein
KXZ66_RS14815	COG3534	alpha-L-arabinofuranosidase
KXZ66_RS14820	COG0395	ABC-type sugar transport system, permease component
KXZ66_RS14825	COG1175	transmembrane transport
KXZ66_RS14830	COG1653	transport
KXZ66_RS14835	COG0371	Dehydrogenase
KXZ66_RS14840	COG0647	UMP catabolic process
KXZ66_RS14845	COG0235	Class ii aldolase
KXZ66_RS14850	COG1069	ribulokinase activity
KXZ66_RS14855	COG2160	L-arabinose isomerase activity
KXZ66_RS14860	COG3507	Belongs to the glycosyl hydrolase 43 family
KXZ66_RS14865	COG1363	Peptidase, m42
KXZ66_RS14875	COG3326	Membrane
KXZ66_RS14880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KXZ66_RS14885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KXZ66_RS14890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KXZ66_RS14900	COG1346	cytolysis
KXZ66_RS14905	COG1380	Effector of murein hydrolase LrgA
KXZ66_RS14910	COG3279	Response regulator of the LytR AlgR family
KXZ66_RS14915	COG3275	phosphorelay sensor kinase activity
KXZ66_RS14920	COG1011	Hydrolase
KXZ66_RS14925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KXZ66_RS14935	COG0398	Pfam SNARE associated Golgi protein
KXZ66_RS14940	COG1484	DNA-dependent DNA replication
KXZ66_RS14945	COG3611	Membrane attachment protein
KXZ66_RS14950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KXZ66_RS14955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KXZ66_RS14960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KXZ66_RS14965	COG1733	regulation of RNA biosynthetic process
KXZ66_RS14970	COG2814	Major facilitator Superfamily
KXZ66_RS14975	COG0656	L-ascorbic acid biosynthetic process
KXZ66_RS14980	COG0237	dephospho-CoA kinase activity
KXZ66_RS14990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KXZ66_RS14995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KXZ66_RS14995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KXZ66_RS15000	COG5002	protein histidine kinase activity
KXZ66_RS15005	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS15010	COG0039	L-malate dehydrogenase activity
KXZ66_RS15015	COG0538	isocitrate dehydrogenase activity
KXZ66_RS15020	COG0372	Belongs to the citrate synthase family
KXZ66_RS15025	COG2707	UPF0756 membrane protein
KXZ66_RS15030	COG0628	permease
KXZ66_RS15035	COG3030	protein affecting phage T7 exclusion by the F plasmid
KXZ66_RS15040	COG0469	pyruvate kinase activity
KXZ66_RS15045	COG0205	6-phosphofructokinase activity
KXZ66_RS15050	COG0825	malonyl-CoA metabolic process
KXZ66_RS15055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KXZ66_RS15060	COG0281	malic enzyme
KXZ66_RS15065	COG0587	DNA-directed DNA polymerase activity
KXZ66_RS15085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KXZ66_RS15095	COG4109	DRTGG domain
KXZ66_RS15100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KXZ66_RS15105	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS15110	COG0165	Argininosuccinate lyase
KXZ66_RS15115	COG0137	argininosuccinate synthase activity
KXZ66_RS15120	COG0521	Mo-molybdopterin cofactor biosynthetic process
KXZ66_RS15125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KXZ66_RS15135	COG0827	DNA restriction-modification system
KXZ66_RS15140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KXZ66_RS15145	COG3874	Sporulation protein YtfJ
KXZ66_RS15155	COG1714	RDD family
KXZ66_RS15160	COG0616	signal peptide processing
KXZ66_RS15165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KXZ66_RS15170	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KXZ66_RS15175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KXZ66_RS15185	COG0301	tRNA thio-modification
KXZ66_RS15190	COG1104	cysteine desulfurase activity
KXZ66_RS15195	COG1114	Component of the transport system for branched-chain amino acids
KXZ66_RS15200	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KXZ66_RS15205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KXZ66_RS15210	COG1309	transcriptional regulator
KXZ66_RS15215	COG1956	GAF domain-containing protein
KXZ66_RS15220	COG2203	Gaf domain
KXZ66_RS15220	COG2199	diguanylate cyclase activity
KXZ66_RS15225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KXZ66_RS15230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KXZ66_RS15235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KXZ66_RS15240	COG0454	-acetyltransferase
KXZ66_RS15245	COG0517	IMP dehydrogenase activity
KXZ66_RS15250	COG0123	including yeast histone deacetylase and acetoin utilization protein
KXZ66_RS15255	COG1360	Flagellar Motor Protein
KXZ66_RS15260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KXZ66_RS15265	COG1609	Transcriptional regulator
KXZ66_RS15270	COG1605	Chorismate mutase
KXZ66_RS15270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KXZ66_RS15275	COG3118	belongs to the thioredoxin family
KXZ66_RS15280	COG4980	gas vesicle protein
KXZ66_RS15285	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KXZ66_RS15290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KXZ66_RS15295	COG1674	ftsk spoiiie
KXZ66_RS15300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KXZ66_RS15305	COG4848	Belongs to the UPF0354 family
KXZ66_RS15310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS15325	COG1363	Peptidase, m42
KXZ66_RS15330	COG5584	Small secreted protein
KXZ66_RS15335	COG0281	malic enzyme
KXZ66_RS15340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KXZ66_RS15345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KXZ66_RS15355	COG0510	thiamine kinase activity
KXZ66_RS15360	COG1523	belongs to the glycosyl hydrolase 13 family
KXZ66_RS15365	COG1597	lipid kinase activity
KXZ66_RS15375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KXZ66_RS15380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KXZ66_RS15385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KXZ66_RS15390	COG2252	PERMEase
KXZ66_RS15395	COG4473	ABC transporter
KXZ66_RS15400	COG1131	(ABC) transporter
KXZ66_RS15405	COG1349	DNA-binding transcription factor activity
KXZ66_RS15410	COG1187	pseudouridine synthase activity
KXZ66_RS15415	COG2244	polysaccharide biosynthetic process
KXZ66_RS15420	COG2081	HI0933 family
KXZ66_RS15425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KXZ66_RS15435	COG5578	integral membrane protein
KXZ66_RS15440	COG0673	inositol 2-dehydrogenase activity
KXZ66_RS15445	COG1653	transport
KXZ66_RS15450	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KXZ66_RS15455	COG4209	transmembrane transport
KXZ66_RS15460	COG2207	Transcriptional regulator
KXZ66_RS15465	COG1653	transport
KXZ66_RS15470	COG0395	ABC-type sugar transport system, permease component
KXZ66_RS15475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KXZ66_RS15480	COG2124	cytochrome p450
KXZ66_RS15485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KXZ66_RS15495	COG0156	8-amino-7-oxononanoate synthase activity
KXZ66_RS15500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KXZ66_RS15510	COG1073	alpha beta
KXZ66_RS15515	COG1609	Transcriptional regulator
KXZ66_RS15520	COG1653	transport
KXZ66_RS15525	COG1175	transmembrane transport
KXZ66_RS15530	COG0395	ABC-type sugar transport system, permease component
KXZ66_RS15535	COG1486	melibiose metabolic process
KXZ66_RS15540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KXZ66_RS15545	COG0495	leucyl-tRNA aminoacylation
KXZ66_RS15555	COG2202	Pas domain
KXZ66_RS15555	COG1366	Belongs to the anti-sigma-factor antagonist family
KXZ66_RS15560	COG2814	Major facilitator Superfamily
KXZ66_RS15565	COG2433	Pfam Transposase IS66
KXZ66_RS15570	COG0577	efflux transmembrane transporter activity
KXZ66_RS15575	COG1136	(ABC) transporter
KXZ66_RS15580	COG2205	protein histidine kinase activity
KXZ66_RS15585	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS15590	COG0577	efflux transmembrane transporter activity
KXZ66_RS15595	COG1136	(ABC) transporter
KXZ66_RS15610	COG1131	(ABC) transporter
KXZ66_RS15615	COG1725	Transcriptional regulator
KXZ66_RS15630	COG1242	4 iron, 4 sulfur cluster binding
KXZ66_RS15635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KXZ66_RS15645	COG2267	carboxylic ester hydrolase activity
KXZ66_RS15650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KXZ66_RS15655	COG1113	amino acid transport
KXZ66_RS15660	COG0367	asparagine synthase
KXZ66_RS15665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KXZ66_RS15670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KXZ66_RS15680	COG1506	peptidase
KXZ66_RS15685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KXZ66_RS15690	COG1116	anion transmembrane transporter activity
KXZ66_RS15695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KXZ66_RS15700	COG0494	nUDIX hydrolase
KXZ66_RS15705	COG4824	toxin secretion phage lysis holin
KXZ66_RS15710	COG0783	Belongs to the Dps family
KXZ66_RS15725	COG1854	S-ribosylhomocysteine lyase activity
KXZ66_RS15730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KXZ66_RS15735	COG0288	reversible hydration of carbon dioxide
KXZ66_RS15740	COG0254	rRNA binding
KXZ66_RS15745	COG1271	oxidase subunit
KXZ66_RS15750	COG1294	oxidase, subunit
KXZ66_RS15760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KXZ66_RS15765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KXZ66_RS15765	COG1321	iron dependent repressor
KXZ66_RS15770	COG1121	(ABC) transporter
KXZ66_RS15775	COG0803	Belongs to the bacterial solute-binding protein 9 family
KXZ66_RS15780	COG4948	Mandelate Racemase Muconate Lactonizing
KXZ66_RS15785	COG0318	PFAM AMP-dependent synthetase and ligase
KXZ66_RS15790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KXZ66_RS15795	COG0596	Alpha beta hydrolase
KXZ66_RS15800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KXZ66_RS15805	COG1169	isochorismate synthase
KXZ66_RS15810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KXZ66_RS15815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KXZ66_RS15820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KXZ66_RS15825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KXZ66_RS15830	COG0438	transferase activity, transferring glycosyl groups
KXZ66_RS15840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KXZ66_RS15845	COG0438	transferase activity, transferring glycosyl groups
KXZ66_RS15850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KXZ66_RS15855	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
KXZ66_RS15860	COG0058	SHG alpha-glucan phosphorylase activity
KXZ66_RS15865	COG0297	glycogen (starch) synthase activity
KXZ66_RS15870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KXZ66_RS15875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KXZ66_RS15880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KXZ66_RS16005	COG3859	Proton-coupled thiamine transporter YuaJ
KXZ66_RS16010	COG1247	-acetyltransferase
KXZ66_RS16015	COG2268	Band 7 protein
KXZ66_RS16020	COG1585	Membrane protein implicated in regulation of membrane protease activity
KXZ66_RS16025	COG2318	DinB family
KXZ66_RS16035	COG1454	alcohol dehydrogenase
KXZ66_RS16040	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS16045	COG1510	regulation of RNA biosynthetic process
KXZ66_RS16055	COG0569	domain protein
KXZ66_RS16060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KXZ66_RS16065	COG4682	membrane
KXZ66_RS16070	COG1705	Flagellar rod assembly protein muramidase FlgJ
KXZ66_RS16075	COG0477	Major facilitator Superfamily
KXZ66_RS16080	COG5553	Cysteine dioxygenase type I
KXZ66_RS16090	COG1968	undecaprenyl-diphosphatase activity
KXZ66_RS16095	COG0628	permease
KXZ66_RS16100	COG0673	inositol 2-dehydrogenase activity
KXZ66_RS16105	COG4806	L-rhamnose isomerase
KXZ66_RS16110	COG3254	rhamnose metabolic process
KXZ66_RS16115	COG1070	Carbohydrate kinase
KXZ66_RS16120	COG1349	DNA-binding transcription factor activity
KXZ66_RS16125	COG3347	Dehydrogenase
KXZ66_RS16125	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS16130	COG0840	transmembrane signaling receptor activity
KXZ66_RS16135	COG0840	transmembrane signaling receptor activity
KXZ66_RS16140	COG0840	transmembrane signaling receptor activity
KXZ66_RS16145	COG0840	transmembrane signaling receptor activity
KXZ66_RS16160	COG0432	Pfam Uncharacterised protein family UPF0047
KXZ66_RS16170	COG0366	Alpha amylase catalytic
KXZ66_RS16175	COG1253	flavin adenine dinucleotide binding
KXZ66_RS16180	COG2738	Putative neutral zinc metallopeptidase
KXZ66_RS16195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KXZ66_RS16210	COG0166	Belongs to the GPI family
KXZ66_RS16215	COG1979	alcohol dehydrogenase
KXZ66_RS16220	COG1979	alcohol dehydrogenase
KXZ66_RS16225	COG2155	Conserved Protein
KXZ66_RS16230	COG1098	S1 RNA binding domain
KXZ66_RS16235	COG0436	Aminotransferase
KXZ66_RS16240	COG1522	sequence-specific DNA binding
KXZ66_RS16245	COG2267	carboxylic ester hydrolase activity
KXZ66_RS16255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KXZ66_RS16260	COG2205	protein histidine kinase activity
KXZ66_RS16270	COG5018	Exonuclease
KXZ66_RS16275	COG2814	Major facilitator Superfamily
KXZ66_RS16280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KXZ66_RS16285	COG3011	Protein conserved in bacteria
KXZ66_RS16295	COG3290	protein histidine kinase activity
KXZ66_RS16300	COG4565	transcriptional regulatory protein
KXZ66_RS16305	COG1744	ABC transporter substrate-binding protein PnrA-like
KXZ66_RS16310	COG3845	ABC transporter
KXZ66_RS16315	COG4603	Belongs to the binding-protein-dependent transport system permease family
KXZ66_RS16320	COG1079	Belongs to the binding-protein-dependent transport system permease family
KXZ66_RS16325	COG3493	citrate carrier protein
KXZ66_RS16335	COG2111	Na H antiporter
KXZ66_RS16335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KXZ66_RS16340	COG2111	Na H antiporter
KXZ66_RS16345	COG1006	Multisubunit Na H antiporter MnhC subunit
KXZ66_RS16350	COG0651	ATP synthesis coupled electron transport
KXZ66_RS16355	COG1863	multisubunit Na H antiporter MnhE subunit
KXZ66_RS16360	COG2212	antiporter activity
KXZ66_RS16365	COG1320	monovalent cation:proton antiporter activity
KXZ66_RS16370	COG2050	protein possibly involved in aromatic compounds catabolism
KXZ66_RS16375	COG2197	response regulator
KXZ66_RS16390	COG0142	geranyltranstransferase activity
KXZ66_RS16405	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KXZ66_RS16410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KXZ66_RS16415	COG1335	isochorismatase
KXZ66_RS16420	COG5506	Protein of unknown function (DUF1694)
KXZ66_RS16435	COG0628	permease
KXZ66_RS16450	COG1418	mRNA catabolic process
KXZ66_RS16455	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS16465	COG1511	domain protein
KXZ66_RS16470	COG1674	ftsk spoiiie
KXZ66_RS16470	COG0433	COG0433 Predicted ATPase
KXZ66_RS16475	COG4499	WXG100 protein secretion system (Wss), protein YukC
KXZ66_RS16480	COG5417	Belongs to the EsaB family
KXZ66_RS16485	COG4842	Belongs to the WXG100 family
KXZ66_RS16490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KXZ66_RS16490	COG2508	Transcriptional regulator
KXZ66_RS16495	COG0686	Belongs to the AlaDH PNT family
KXZ66_RS16500	COG5634	Uncharacterized conserved protein (DUF2278)
KXZ66_RS16505	COG3251	PFAM MbtH domain protein
KXZ66_RS16510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS16515	COG1535	isochorismatase
KXZ66_RS16515	COG3433	isochorismatase activity
KXZ66_RS16520	COG1021	2,3-dihydroxybenzoate-AMP ligase
KXZ66_RS16525	COG1169	isochorismate synthase
KXZ66_RS16530	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS16535	COG2819	hydrolase of the alpha beta superfamily
KXZ66_RS16540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KXZ66_RS16545	COG1268	BioY protein
KXZ66_RS16550	COG2056	Na+-H+ antiporter family
KXZ66_RS16555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KXZ66_RS16560	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KXZ66_RS16565	COG3584	3D domain protein
KXZ66_RS16580	COG1252	NADH dehydrogenase
KXZ66_RS16585	COG0492	ferredoxin-NADP+ reductase activity
KXZ66_RS16595	COG0516	GMP reductase activity
KXZ66_RS16600	COG2808	Putative FMN-binding domain
KXZ66_RS16605	COG0456	acetyltransferase
KXZ66_RS16610	COG0316	Belongs to the HesB IscA family
KXZ66_RS16615	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KXZ66_RS16620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KXZ66_RS16625	COG4844	belongs to the
KXZ66_RS16630	COG1252	NADH dehydrogenase
KXZ66_RS16635	COG4837	Protein of unknown function (DUF1462)
KXZ66_RS16640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KXZ66_RS16645	COG1506	peptidase
KXZ66_RS16645	COG0823	Involved in the tonB-independent uptake of proteins
KXZ66_RS16645	COG4946	Tricorn protease homolog
KXZ66_RS16650	COG0083	homoserine kinase activity
KXZ66_RS16655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KXZ66_RS16660	COG0460	homoserine dehydrogenase
KXZ66_RS16665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KXZ66_RS16670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KXZ66_RS16675	COG0647	UMP catabolic process
KXZ66_RS16680	COG2445	Protein of unknown function DUF86
KXZ66_RS16685	COG4470	Protein conserved in bacteria
KXZ66_RS16695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KXZ66_RS16700	COG0739	heme binding
KXZ66_RS16710	COG3377	Domain of unknown function (DUF1805)
KXZ66_RS16715	COG0737	Belongs to the 5'-nucleotidase family
KXZ66_RS16720	COG0730	response to heat
KXZ66_RS16725	COG1801	Protein of unknown function DUF72
KXZ66_RS16735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KXZ66_RS16740	COG2508	Transcriptional regulator
KXZ66_RS16745	COG2233	PERMEase
KXZ66_RS16750	COG2233	PERMEase
KXZ66_RS16755	COG3195	allantoin biosynthetic process
KXZ66_RS16755	COG3648	Uricase
KXZ66_RS16760	COG2351	hydroxyisourate hydrolase activity
KXZ66_RS16770	COG2080	2 iron, 2 sulfur cluster binding
KXZ66_RS16775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KXZ66_RS16780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KXZ66_RS16785	COG2068	MobA-Related Protein
KXZ66_RS16790	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KXZ66_RS16795	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KXZ66_RS16800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KXZ66_RS16810	COG2356	endonuclease I
KXZ66_RS16815	COG3842	ATPase activity
KXZ66_RS16820	COG2188	Transcriptional regulator
KXZ66_RS16825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KXZ66_RS16830	COG0395	ABC-type sugar transport system, permease component
KXZ66_RS16835	COG1175	transmembrane transport
KXZ66_RS16840	COG1653	transport
KXZ66_RS16845	COG2222	sugar isomerase
KXZ66_RS16850	COG0322	excinuclease ABC activity
KXZ66_RS16855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KXZ66_RS16870	COG0346	lactoylglutathione lyase activity
KXZ66_RS16875	COG0640	Transcriptional regulator
KXZ66_RS16880	COG0719	Fe-S assembly protein
KXZ66_RS16885	COG0822	iron-sulfur transferase activity
KXZ66_RS16890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KXZ66_RS16895	COG0719	Fe-S assembly protein
KXZ66_RS16900	COG0396	ATPase activity
KXZ66_RS16910	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KXZ66_RS16915	COG1464	Belongs to the NlpA lipoprotein family
KXZ66_RS16920	COG2011	ABC-type metal ion transport system permease component
KXZ66_RS16925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KXZ66_RS16935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KXZ66_RS16940	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KXZ66_RS16950	COG0509	glycine decarboxylation via glycine cleavage system
KXZ66_RS16955	COG1393	Belongs to the ArsC family
KXZ66_RS16960	COG1960	acyl-CoA dehydrogenase activity
KXZ66_RS16965	COG0183	Belongs to the thiolase family
KXZ66_RS16970	COG1250	3-hydroxyacyl-CoA dehydrogenase
KXZ66_RS16970	COG1024	Enoyl-CoA hydratase
KXZ66_RS16980	COG0506	proline dehydrogenase activity
KXZ66_RS16990	COG5577	PFAM Coat F domain
KXZ66_RS16995	COG1846	Transcriptional regulator
KXZ66_RS17000	COG0477	Major facilitator Superfamily
KXZ66_RS17005	COG1942	4-Oxalocrotonate Tautomerase
KXZ66_RS17010	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS17015	COG0583	DNA-binding transcription factor activity
KXZ66_RS17025	COG1120	ATPase activity
KXZ66_RS17040	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS17045	COG0783	Belongs to the Dps family
KXZ66_RS17050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KXZ66_RS17055	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS17060	COG2205	protein histidine kinase activity
KXZ66_RS17060	COG2770	Histidine kinase
KXZ66_RS17070	COG1309	transcriptional regulator
KXZ66_RS17075	COG0114	fumarate hydratase activity
KXZ66_RS17085	COG0697	spore germination
KXZ66_RS17090	COG0814	amino acid
KXZ66_RS17100	COG2197	response regulator
KXZ66_RS17105	COG4585	Histidine kinase
KXZ66_RS17110	COG4758	membrane
KXZ66_RS17115	COG3595	metallopeptidase activity
KXZ66_RS17120	COG1842	Phage shock protein A
KXZ66_RS17125	COG4758	membrane
KXZ66_RS17130	COG2814	Major facilitator Superfamily
KXZ66_RS17135	COG2096	Adenosyltransferase
KXZ66_RS17140	COG1120	ATPase activity
KXZ66_RS17145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS17150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KXZ66_RS17155	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS17160	COG3386	PFAM SMP-30 Gluconolaconase
KXZ66_RS17165	COG2205	protein histidine kinase activity
KXZ66_RS17170	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS17180	COG1191	sigma factor activity
KXZ66_RS17190	COG2140	Oxalate decarboxylase
KXZ66_RS17200	COG0577	efflux transmembrane transporter activity
KXZ66_RS17205	COG1136	(ABC) transporter
KXZ66_RS17210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KXZ66_RS17215	COG1120	ATPase activity
KXZ66_RS17220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS17225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KXZ66_RS17230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KXZ66_RS17235	COG0531	amino acid
KXZ66_RS17245	COG1988	membrane-bound metal-dependent
KXZ66_RS17250	COG1368	sulfuric ester hydrolase activity
KXZ66_RS17255	COG1910	domain protein
KXZ66_RS17260	COG0725	ABC transporter, periplasmic molybdate-binding protein
KXZ66_RS17265	COG4149	molybdate abc transporter
KXZ66_RS17270	COG0656	L-ascorbic acid biosynthetic process
KXZ66_RS17280	COG0025	NhaP-type Na H and K H
KXZ66_RS17285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KXZ66_RS17290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KXZ66_RS17295	COG3973	AAA domain
KXZ66_RS17305	COG2860	membrane
KXZ66_RS17310	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KXZ66_RS17315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KXZ66_RS17320	COG2217	Heavy metal translocating P-type atpase
KXZ66_RS17325	COG2217	Heavy metal translocating P-type atpase
KXZ66_RS17330	COG2608	mercury ion transmembrane transporter activity
KXZ66_RS17335	COG1937	Protein conserved in bacteria
KXZ66_RS17340	COG0673	inositol 2-dehydrogenase activity
KXZ66_RS17345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KXZ66_RS17350	COG1289	transmembrane transporter activity
KXZ66_RS17360	COG2076	Multidrug Resistance protein
KXZ66_RS17365	COG1309	transcriptional regulator
KXZ66_RS17370	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS17395	COG5444	nuclease activity
KXZ66_RS17410	COG3409	Peptidoglycan-binding domain 1 protein
KXZ66_RS17410	COG5632	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS17415	COG4824	toxin secretion phage lysis holin
KXZ66_RS17450	COG1705	Flagellar rod assembly protein muramidase FlgJ
KXZ66_RS17450	COG3942	CHAP domain
KXZ66_RS17570	COG0582	viral genome integration into host DNA
KXZ66_RS17690	COG0582	viral genome integration into host DNA
KXZ66_RS17700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KXZ66_RS17705	COG0557	exoribonuclease II activity
KXZ66_RS17710	COG1647	Serine aminopeptidase, S33
KXZ66_RS17715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KXZ66_RS17720	COG0596	Alpha beta hydrolase
KXZ66_RS17725	COG1476	TRANSCRIPTIONal
KXZ66_RS17730	COG1396	sequence-specific DNA binding
KXZ66_RS17735	COG1396	sequence-specific DNA binding
KXZ66_RS17740	COG1733	regulation of RNA biosynthetic process
KXZ66_RS17745	COG0840	transmembrane signaling receptor activity
KXZ66_RS17770	COG1131	(ABC) transporter
KXZ66_RS17800	COG1174	glycine betaine transport
KXZ66_RS17805	COG1732	Glycine betaine
KXZ66_RS17810	COG1174	glycine betaine transport
KXZ66_RS17815	COG1125	glycine betaine transport
KXZ66_RS17815	COG0517	IMP dehydrogenase activity
KXZ66_RS17820	COG1510	regulation of RNA biosynthetic process
KXZ66_RS17825	COG1174	glycine betaine transport
KXZ66_RS17830	COG1732	Glycine betaine
KXZ66_RS17835	COG1174	glycine betaine transport
KXZ66_RS17840	COG0517	IMP dehydrogenase activity
KXZ66_RS17840	COG1125	glycine betaine transport
KXZ66_RS17845	COG1510	regulation of RNA biosynthetic process
KXZ66_RS17850	COG2095	MarC family integral membrane protein
KXZ66_RS17860	COG3064	Membrane
KXZ66_RS17865	COG4640	response to antibiotic
KXZ66_RS17870	COG0456	acetyltransferase
KXZ66_RS17875	COG0148	phosphopyruvate hydratase activity
KXZ66_RS17880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KXZ66_RS17885	COG0149	triose-phosphate isomerase activity
KXZ66_RS17890	COG0126	phosphoglycerate kinase activity
KXZ66_RS17895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KXZ66_RS17900	COG2390	Transcriptional regulator
KXZ66_RS17905	COG2814	Major facilitator Superfamily
KXZ66_RS17910	COG1609	Transcriptional regulator
KXZ66_RS17915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KXZ66_RS17920	COG0583	DNA-binding transcription factor activity
KXZ66_RS17925	COG0697	spore germination
KXZ66_RS17930	COG1113	amino acid transport
KXZ66_RS17935	COG3858	chitin binding
KXZ66_RS17940	COG1556	Lactate utilization protein
KXZ66_RS17945	COG1139	Iron-sulfur cluster binding protein
KXZ66_RS17950	COG0247	lactate metabolic process
KXZ66_RS17955	COG2197	response regulator
KXZ66_RS17960	COG4585	Histidine kinase
KXZ66_RS17965	COG0842	Transport permease protein
KXZ66_RS17970	COG1131	(ABC) transporter
KXZ66_RS17975	COG0596	Alpha beta hydrolase
KXZ66_RS17980	COG2208	phosphoserine phosphatase activity
KXZ66_RS17985	COG3867	Arabinogalactan endo-beta-1,4-galactanase
KXZ66_RS17990	COG1874	Beta-galactosidase
KXZ66_RS17995	COG3833	ABC-type maltose transport systems, permease component
KXZ66_RS18000	COG1175	transmembrane transport
KXZ66_RS18005	COG2182	Extracellular solute-binding protein
KXZ66_RS18010	COG1609	Transcriptional regulator
KXZ66_RS18015	COG2186	Transcriptional regulator
KXZ66_RS18020	COG1620	l-lactate permease
KXZ66_RS18025	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KXZ66_RS18035	COG5039	Polysaccharide pyruvyl transferase
KXZ66_RS18040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KXZ66_RS18045	COG0110	maltose O-acetyltransferase activity
KXZ66_RS18050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KXZ66_RS18055	COG2244	polysaccharide biosynthetic process
KXZ66_RS18060	COG1216	Glycosyl transferase, family 2
KXZ66_RS18065	COG5039	Polysaccharide pyruvyl transferase
KXZ66_RS18070	COG1216	Glycosyl transferase, family 2
KXZ66_RS18080	COG0438	transferase activity, transferring glycosyl groups
KXZ66_RS18085	COG1215	transferase activity, transferring glycosyl groups
KXZ66_RS18090	COG0438	transferase activity, transferring glycosyl groups
KXZ66_RS18095	COG1086	Polysaccharide biosynthesis protein
KXZ66_RS18100	COG0489	protein tyrosine kinase activity
KXZ66_RS18105	COG3944	biosynthesis protein
KXZ66_RS18110	COG1396	sequence-specific DNA binding
KXZ66_RS18115	COG2272	Belongs to the type-B carboxylesterase lipase family
KXZ66_RS18125	COG3479	Phenolic acid decarboxylase
KXZ66_RS18135	COG1794	racemase activity, acting on amino acids and derivatives
KXZ66_RS18140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KXZ66_RS18145	COG1621	beta-fructofuranosidase activity
KXZ66_RS18150	COG1621	beta-fructofuranosidase activity
KXZ66_RS18155	COG0531	amino acid
KXZ66_RS18160	COG1309	transcriptional regulator
KXZ66_RS18165	COG2076	Multidrug Resistance protein
KXZ66_RS18170	COG2076	Multidrug Resistance protein
KXZ66_RS18185	COG0740	serine-type endopeptidase activity
KXZ66_RS18190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KXZ66_RS18195	COG0366	Alpha amylase catalytic
KXZ66_RS18200	COG1554	hydrolase, family 65, central catalytic
KXZ66_RS18205	COG5521	maltodextrose utilization protein MalA
KXZ66_RS18210	COG3833	ABC-type maltose transport systems, permease component
KXZ66_RS18215	COG1175	transmembrane transport
KXZ66_RS18220	COG2182	Extracellular solute-binding protein
KXZ66_RS18230	COG1609	Transcriptional regulator
KXZ66_RS18235	COG1611	Belongs to the LOG family
KXZ66_RS18240	COG1694	Mazg nucleotide pyrophosphohydrolase
KXZ66_RS18245	COG0659	secondary active sulfate transmembrane transporter activity
KXZ66_RS18250	COG0288	reversible hydration of carbon dioxide
KXZ66_RS18255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KXZ66_RS18260	COG0577	efflux transmembrane transporter activity
KXZ66_RS18265	COG1136	(ABC) transporter
KXZ66_RS18270	COG5002	protein histidine kinase activity
KXZ66_RS18275	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS18285	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KXZ66_RS18290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KXZ66_RS18295	COG1481	regulation of sporulation
KXZ66_RS18300	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KXZ66_RS18305	COG1660	Displays ATPase and GTPase activities
KXZ66_RS18310	COG1051	belongs to the nudix hydrolase family
KXZ66_RS18315	COG0492	ferredoxin-NADP+ reductase activity
KXZ66_RS18320	COG3883	PFAM NLP P60 protein
KXZ66_RS18320	COG0791	NLP P60 protein
KXZ66_RS18325	COG0457	Tetratricopeptide repeat
KXZ66_RS18330	COG1132	(ABC) transporter
KXZ66_RS18350	COG0140	phosphoribosyl-ATP diphosphatase activity
KXZ66_RS18350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KXZ66_RS18355	COG0107	imidazoleglycerol-phosphate synthase activity
KXZ66_RS18360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KXZ66_RS18365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KXZ66_RS18370	COG0131	Imidazoleglycerol-phosphate dehydratase
KXZ66_RS18375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KXZ66_RS18380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KXZ66_RS18385	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KXZ66_RS18390	COG4990	cell redox homeostasis
KXZ66_RS18395	COG5297	Belongs to the glycosyl hydrolase family 6
KXZ66_RS18400	COG0110	maltose O-acetyltransferase activity
KXZ66_RS18405	COG0546	phosphoglycolate phosphatase activity
KXZ66_RS18410	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KXZ66_RS18415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KXZ66_RS18420	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KXZ66_RS18425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KXZ66_RS18430	COG0363	glucosamine-6-phosphate deaminase activity
KXZ66_RS18435	COG2188	Transcriptional regulator
KXZ66_RS18440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KXZ66_RS18445	COG1846	Transcriptional regulator
KXZ66_RS18460	COG1846	Transcriptional regulator
KXZ66_RS18465	COG2814	Major facilitator Superfamily
KXZ66_RS18470	COG1950	PFAM Membrane protein of
KXZ66_RS18475	COG1983	PspC domain protein
KXZ66_RS18480	COG3595	metallopeptidase activity
KXZ66_RS18500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KXZ66_RS18505	COG0556	nucleotide-excision repair
KXZ66_RS18510	COG4897	Protein conserved in bacteria
KXZ66_RS18515	COG3848	Pyruvate phosphate dikinase
KXZ66_RS18515	COG0574	Belongs to the PEP-utilizing enzyme family
KXZ66_RS18520	COG1309	transcriptional regulator
KXZ66_RS18525	COG2814	Major facilitator Superfamily
KXZ66_RS18530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KXZ66_RS18540	COG3409	Peptidoglycan-binding domain 1 protein
KXZ66_RS18540	COG0793	Belongs to the peptidase S41A family
KXZ66_RS18545	COG2177	Part of the ABC transporter FtsEX involved in
KXZ66_RS18550	COG2884	Cell division ATP-binding protein ftsE
KXZ66_RS18555	COG2010	Cytochrome c
KXZ66_RS18560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KXZ66_RS18570	COG0653	protein targeting
KXZ66_RS18575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KXZ66_RS18590	COG1516	flagellar protein fliS
KXZ66_RS18595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KXZ66_RS18600	COG1334	flagellar protein FlaG
KXZ66_RS18605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KXZ66_RS18610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KXZ66_RS18615	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
KXZ66_RS18625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KXZ66_RS18630	COG1256	bacterial-type flagellum assembly
KXZ66_RS18630	COG4786	Flagellar basal body rod
KXZ66_RS18635	COG3418	PFAM FlgN family protein
KXZ66_RS18640	COG2747	anti-sigma28 factor FlgM
KXZ66_RS18650	COG1040	competence protein
KXZ66_RS18660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KXZ66_RS18665	COG1307	EDD domain protein, DegV family
KXZ66_RS18670	COG2197	response regulator
KXZ66_RS18675	COG4585	Histidine kinase
KXZ66_RS18680	COG1739	Uncharacterized protein family UPF0029
KXZ66_RS18685	COG1316	TRANSCRIPTIONal
KXZ66_RS18690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KXZ66_RS18695	COG0438	transferase activity, transferring glycosyl groups
KXZ66_RS18700	COG1215	transferase activity, transferring glycosyl groups
KXZ66_RS18705	COG3206	protein involved in exopolysaccharide biosynthesis
KXZ66_RS18710	COG3307	-O-antigen
KXZ66_RS18715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KXZ66_RS18720	COG0297	glycogen (starch) synthase activity
KXZ66_RS18720	COG0438	transferase activity, transferring glycosyl groups
KXZ66_RS18725	COG2244	polysaccharide biosynthetic process
KXZ66_RS18740	COG0860	N-Acetylmuramoyl-L-alanine amidase
KXZ66_RS18740	COG2247	cell wall binding repeat
KXZ66_RS18745	COG2247	cell wall binding repeat
KXZ66_RS18745	COG2385	sporulation resulting in formation of a cellular spore
KXZ66_RS18755	COG1316	TRANSCRIPTIONal
KXZ66_RS18760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KXZ66_RS18780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KXZ66_RS18785	COG1134	teichoic acid transport
KXZ66_RS18790	COG1682	transport, permease protein
KXZ66_RS18795	COG0438	transferase activity, transferring glycosyl groups
KXZ66_RS18800	COG1215	transferase activity, transferring glycosyl groups
KXZ66_RS18800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KXZ66_RS18845	COG4193	domain, Protein
KXZ66_RS18850	COG1482	cell wall glycoprotein biosynthetic process
KXZ66_RS18855	COG0697	spore germination
KXZ66_RS18860	COG0814	amino acid
KXZ66_RS18870	COG2814	Major facilitator Superfamily
KXZ66_RS18875	COG1316	TRANSCRIPTIONal
KXZ66_RS18880	COG0561	phosphatase activity
KXZ66_RS18885	COG0791	NLP P60 protein
KXZ66_RS18895	COG2843	Capsule synthesis protein
KXZ66_RS18905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KXZ66_RS18910	COG1609	Transcriptional regulator
KXZ66_RS18915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KXZ66_RS18920	COG1869	D-ribose catabolic process
KXZ66_RS18925	COG1129	ABC transporter
KXZ66_RS18930	COG1172	Belongs to the binding-protein-dependent transport system permease family
KXZ66_RS18935	COG1879	ABC-type sugar transport system periplasmic component
KXZ66_RS18940	COG3103	Sh3 type 3 domain protein
KXZ66_RS18950	COG2249	NAD(P)H dehydrogenase (quinone) activity
KXZ66_RS18955	COG3527	Alpha-acetolactate decarboxylase
KXZ66_RS18960	COG0028	Belongs to the TPP enzyme family
KXZ66_RS18965	COG0583	DNA-binding transcription factor activity
KXZ66_RS18970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KXZ66_RS18985	COG5337	Spore coat protein CotH
KXZ66_RS18995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KXZ66_RS19010	COG1522	sequence-specific DNA binding
KXZ66_RS19015	COG2059	Chromate
KXZ66_RS19020	COG2059	Chromate
KXZ66_RS19030	COG0655	NAD(P)H dehydrogenase (quinone) activity
KXZ66_RS19035	COG0583	DNA-binding transcription factor activity
KXZ66_RS19040	COG1515	deoxyribonuclease V activity
KXZ66_RS19070	COG5444	nuclease activity
KXZ66_RS19090	COG3878	Protein conserved in bacteria
KXZ66_RS19095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KXZ66_RS19100	COG4464	protein tyrosine phosphatase activity
KXZ66_RS19105	COG0489	protein tyrosine kinase activity
KXZ66_RS19110	COG3944	biosynthesis protein
KXZ66_RS19120	COG4715	Zinc finger, swim domain protein
KXZ66_RS19125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KXZ66_RS19130	COG0561	phosphatase activity
KXZ66_RS19135	COG1349	DNA-binding transcription factor activity
KXZ66_RS19140	COG0629	single-stranded DNA binding
KXZ66_RS19155	COG3764	Sortase (surface protein transpeptidase)
KXZ66_RS19165	COG3279	Response regulator of the LytR AlgR family
KXZ66_RS19175	COG1970	mechanosensitive ion channel activity
KXZ66_RS19180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KXZ66_RS19185	COG0457	Tetratricopeptide repeat
KXZ66_RS19190	COG4786	Flagellar basal body rod
KXZ66_RS19195	COG4786	Flagellar basal body rod
KXZ66_RS19200	COG1077	Cell shape determining protein MreB Mrl
KXZ66_RS19205	COG1609	Transcriptional regulator
KXZ66_RS19215	COG1846	Transcriptional regulator
KXZ66_RS19220	COG2814	Major facilitator Superfamily
KXZ66_RS19225	COG3420	alginic acid biosynthetic process
KXZ66_RS19230	COG1953	Uracil, thiamine, allantoin
KXZ66_RS19235	COG0477	Major facilitator Superfamily
KXZ66_RS19240	COG1335	isochorismatase
KXZ66_RS19250	COG0004	ammonium transporteR
KXZ66_RS19255	COG0347	Belongs to the P(II) protein family
KXZ66_RS19260	COG0671	phosphoesterase, PA-phosphatase related
KXZ66_RS19270	COG0739	heme binding
KXZ66_RS19275	COG1247	-acetyltransferase
KXZ66_RS19295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KXZ66_RS19300	COG0789	Transcriptional regulator
KXZ66_RS19310	COG2910	NAD(P)H-binding
KXZ66_RS19315	COG1959	2 iron, 2 sulfur cluster binding
KXZ66_RS19320	COG0804	urea catabolic process
KXZ66_RS19325	COG0832	Belongs to the urease beta subunit family
KXZ66_RS19330	COG0831	urea catabolic process
KXZ66_RS19345	COG3237	CsbD-like
KXZ66_RS19350	COG1994	Peptidase M50
KXZ66_RS19355	COG0457	Tetratricopeptide repeat
KXZ66_RS19360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KXZ66_RS19365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KXZ66_RS19375	COG2304	oxidoreductase activity
KXZ66_RS19385	COG2304	oxidoreductase activity
KXZ66_RS19390	COG2385	sporulation resulting in formation of a cellular spore
KXZ66_RS19395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KXZ66_RS19405	COG4836	Membrane
KXZ66_RS19415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KXZ66_RS19420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KXZ66_RS19425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KXZ66_RS19430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KXZ66_RS19435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KXZ66_RS19440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KXZ66_RS19450	COG0356	it plays a direct role in the translocation of protons across the membrane
KXZ66_RS19460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KXZ66_RS19465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KXZ66_RS19470	COG4475	Protein of unknown function (DUF436)
KXZ66_RS19475	COG0698	ribose 5-phosphate isomerase
KXZ66_RS19480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KXZ66_RS19485	COG1971	Probably functions as a manganese efflux pump
KXZ66_RS19490	COG0009	L-threonylcarbamoyladenylate synthase
KXZ66_RS19495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KXZ66_RS19515	COG2890	protein-(glutamine-N5) methyltransferase activity
KXZ66_RS19520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KXZ66_RS19525	COG0346	lactoylglutathione lyase activity
KXZ66_RS19530	COG0789	Transcriptional regulator
KXZ66_RS19535	COG0679	Auxin Efflux Carrier
KXZ66_RS19540	COG0281	malic enzyme
KXZ66_RS19545	COG1435	thymidine kinase activity
KXZ66_RS19555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KXZ66_RS19565	COG1494	fructose-1,6-bisphosphatase
KXZ66_RS19570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KXZ66_RS19575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KXZ66_RS19580	COG0191	fructose-bisphosphate aldolase activity
KXZ66_RS19585	COG2204	response regulator
KXZ66_RS19590	COG4821	SIS domain
KXZ66_RS19595	COG0504	CTP synthase activity
KXZ66_RS19600	COG3343	RNA polymerase activity
KXZ66_RS19605	COG1960	acyl-CoA dehydrogenase activity
KXZ66_RS19610	COG0247	lactate metabolic process
KXZ66_RS19610	COG2181	nitrate reductase activity
KXZ66_RS19615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KXZ66_RS19620	COG4294	response to UV
KXZ66_RS19630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KXZ66_RS19635	COG1132	(ABC) transporter
KXZ66_RS19640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KXZ66_RS19645	COG2181	nitrate reductase activity
KXZ66_RS19650	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KXZ66_RS19655	COG1140	nitrate reductase beta subunit
KXZ66_RS19660	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KXZ66_RS19665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KXZ66_RS19675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KXZ66_RS19680	COG2223	nitrite transmembrane transporter activity
KXZ66_RS19685	COG0018	arginyl-trna synthetase
KXZ66_RS19690	COG4506	Protein conserved in bacteria
KXZ66_RS19705	COG0535	radical SAM domain protein
KXZ66_RS19715	COG1131	(ABC) transporter
KXZ66_RS19720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KXZ66_RS19725	COG0612	Peptidase, M16
KXZ66_RS19730	COG0612	Peptidase, M16
KXZ66_RS19740	COG3391	amine dehydrogenase activity
KXZ66_RS19745	COG3391	amine dehydrogenase activity
KXZ66_RS19750	COG0457	Tetratricopeptide repeat
KXZ66_RS19770	COG1131	(ABC) transporter
KXZ66_RS19780	COG0010	Belongs to the arginase family
KXZ66_RS19785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KXZ66_RS19790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KXZ66_RS19805	COG1994	Peptidase M50
KXZ66_RS19810	COG1942	4-Oxalocrotonate Tautomerase
KXZ66_RS19815	COG1846	Transcriptional regulator
KXZ66_RS19820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KXZ66_RS19825	COG0477	Major facilitator Superfamily
KXZ66_RS19830	COG1959	2 iron, 2 sulfur cluster binding
KXZ66_RS19835	COG3465	dGTPase activity
KXZ66_RS19840	COG1078	dGTPase activity
KXZ66_RS19845	COG4844	belongs to the
KXZ66_RS19855	COG0697	spore germination
KXZ66_RS19860	COG0095	Lipoate-protein ligase
KXZ66_RS19865	COG0583	DNA-binding transcription factor activity
KXZ66_RS19870	COG0280	phosphate acetyltransferase
KXZ66_RS19875	COG3253	May function as heme-dependent peroxidase
KXZ66_RS19880	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS19885	COG0436	Aminotransferase
KXZ66_RS19890	COG2814	Major facilitator Superfamily
KXZ66_RS19895	COG0151	Belongs to the GarS family
KXZ66_RS19900	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS19905	COG1917	Cupin 2, conserved barrel domain protein
KXZ66_RS19910	COG0077	Prephenate dehydratase
KXZ66_RS19915	COG2814	Major facilitator Superfamily
KXZ66_RS19920	COG0833	amino acid
KXZ66_RS19925	COG4187	Peptidase family M20/M25/M40
KXZ66_RS19930	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS19935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KXZ66_RS19945	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
KXZ66_RS19950	COG1091	dTDP-4-dehydrorhamnose reductase activity
KXZ66_RS19955	COG1088	dTDP-glucose 4,6-dehydratase activity
KXZ66_RS19960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KXZ66_RS19965	COG3980	spore coat polysaccharide biosynthesis protein
KXZ66_RS19970	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KXZ66_RS19975	COG2089	acid synthase
KXZ66_RS19980	COG0456	acetyltransferase
KXZ66_RS19985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KXZ66_RS19990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KXZ66_RS19995	COG0463	Glycosyl transferase, family 2
KXZ66_RS20005	COG2363	Small membrane protein
KXZ66_RS20010	COG2233	PERMEase
KXZ66_RS20020	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS20025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KXZ66_RS20030	COG1216	Glycosyl transferase, family 2
KXZ66_RS20045	COG1695	Transcriptional regulator
KXZ66_RS20050	COG0351	phosphomethylpyrimidine kinase
KXZ66_RS20060	COG1621	beta-fructofuranosidase activity
KXZ66_RS20065	COG1263	PTS System
KXZ66_RS20065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS20070	COG2116	formate transmembrane transporter activity
KXZ66_RS20075	COG3711	transcriptional antiterminator
KXZ66_RS20085	COG1404	Belongs to the peptidase S8 family
KXZ66_RS20090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KXZ66_RS20095	COG0778	Nitroreductase
KXZ66_RS20100	COG0772	Belongs to the SEDS family
KXZ66_RS20110	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KXZ66_RS20115	COG1845	cytochrome c oxidase, subunit III
KXZ66_RS20120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KXZ66_RS20125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KXZ66_RS20130	COG2261	transglycosylase associated protein
KXZ66_RS20135	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KXZ66_RS20140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KXZ66_RS20145	COG2246	polysaccharide biosynthetic process
KXZ66_RS20150	COG1309	transcriptional regulator
KXZ66_RS20160	COG3162	membrane
KXZ66_RS20165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KXZ66_RS20170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KXZ66_RS20175	COG2837	iron assimilation
KXZ66_RS20180	COG2822	iron ion transport
KXZ66_RS20185	COG0672	)-iron permease
KXZ66_RS20190	COG0352	thiamine-phosphate diphosphorylase activity
KXZ66_RS20195	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KXZ66_RS20200	COG0583	DNA-binding transcription factor activity
KXZ66_RS20205	COG1380	Effector of murein hydrolase LrgA
KXZ66_RS20210	COG1346	cytolysis
KXZ66_RS20215	COG2814	Major facilitator Superfamily
KXZ66_RS20220	COG4895	conserved protein (DUF2196)
KXZ66_RS20225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KXZ66_RS20230	COG0346	lactoylglutathione lyase activity
KXZ66_RS20240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KXZ66_RS20245	COG1404	Belongs to the peptidase S8 family
KXZ66_RS20250	COG1263	PTS System
KXZ66_RS20250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS20255	COG3711	transcriptional antiterminator
KXZ66_RS20260	COG1442	glycosyl transferase family 8
KXZ66_RS20265	COG5522	Integral membrane protein (intg_mem_TP0381)
KXZ66_RS20270	COG1846	Transcriptional regulator
KXZ66_RS20275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KXZ66_RS20280	COG2234	aminopeptidase activity
KXZ66_RS20285	COG2357	RelA SpoT domain protein
KXZ66_RS20290	COG1575	Belongs to the MenA family. Type 1 subfamily
KXZ66_RS20305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS20310	COG1696	Membrane protein involved in D-alanine export
KXZ66_RS20315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KXZ66_RS20320	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KXZ66_RS20325	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
KXZ66_RS20330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KXZ66_RS20335	COG1486	melibiose metabolic process
KXZ66_RS20340	COG1447	Phosphotransferase system cellobiose-specific component IIA
KXZ66_RS20345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KXZ66_RS20350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KXZ66_RS20355	COG3711	transcriptional antiterminator
KXZ66_RS20355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KXZ66_RS20365	COG2094	Belongs to the DNA glycosylase MPG family
KXZ66_RS20370	COG0753	catalase activity
KXZ66_RS20375	COG2814	Major facilitator Superfamily
KXZ66_RS20380	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KXZ66_RS20385	COG1131	(ABC) transporter
KXZ66_RS20405	COG1595	DNA-templated transcription, initiation
KXZ66_RS20410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KXZ66_RS20415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KXZ66_RS20420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KXZ66_RS20425	COG4988	ABC transporter
KXZ66_RS20430	COG1294	oxidase, subunit
KXZ66_RS20435	COG1271	oxidase subunit
KXZ66_RS20440	COG3493	citrate carrier protein
KXZ66_RS20445	COG0501	Belongs to the peptidase M48B family
KXZ66_RS20455	COG0726	polysaccharide deacetylase
KXZ66_RS20460	COG3842	ATPase activity
KXZ66_RS20465	COG2508	Transcriptional regulator
KXZ66_RS20470	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS20475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KXZ66_RS20485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KXZ66_RS20495	COG4585	Histidine kinase
KXZ66_RS20500	COG2197	response regulator
KXZ66_RS20505	COG2195	Cleaves the N-terminal amino acid of tripeptides
KXZ66_RS20515	COG4894	glucomannan catabolic process
KXZ66_RS20520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KXZ66_RS20525	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KXZ66_RS20530	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS20535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KXZ66_RS20540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KXZ66_RS20545	COG2610	gluconate transmembrane transporter activity
KXZ66_RS20550	COG0500	methyltransferase
KXZ66_RS20555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KXZ66_RS20570	COG0693	protein deglycase activity
KXZ66_RS20570	COG0753	catalase activity
KXZ66_RS20575	COG2851	Citrate transporter
KXZ66_RS20580	COG2273	Hydrolase Family 16
KXZ66_RS20585	COG3711	transcriptional antiterminator
KXZ66_RS20595	COG2270	Major facilitator Superfamily
KXZ66_RS20600	COG0513	Belongs to the DEAD box helicase family
KXZ66_RS20675	COG3209	COG3209 Rhs family protein
KXZ66_RS20680	COG0697	spore germination
KXZ66_RS20685	COG0589	response to stress
KXZ66_RS20690	COG2723	6-phospho-beta-galactosidase activity
KXZ66_RS20695	COG2190	(PTS) system
KXZ66_RS20695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KXZ66_RS20695	COG1263	PTS System
KXZ66_RS20705	COG5444	nuclease activity
KXZ66_RS20720	COG3507	Belongs to the glycosyl hydrolase 43 family
KXZ66_RS20735	COG2986	histidine ammonia-lyase
KXZ66_RS20740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KXZ66_RS20745	COG1228	amidohydrolase
KXZ66_RS20750	COG0010	Belongs to the arginase family
KXZ66_RS20755	COG0833	amino acid
KXZ66_RS20760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KXZ66_RS20765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KXZ66_RS20770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KXZ66_RS20775	COG2390	Transcriptional regulator
KXZ66_RS20785	COG3192	ethanolamine utilization protein
KXZ66_RS20790	COG2079	MmgE PrpD family protein
KXZ66_RS20795	COG1473	amidohydrolase
KXZ66_RS20800	COG1126	abc transporter atp-binding protein
KXZ66_RS20805	COG0765	amino acid transport
KXZ66_RS20810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KXZ66_RS20815	COG0456	acetyltransferase
KXZ66_RS20820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KXZ66_RS20830	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KXZ66_RS20835	COG0561	phosphatase activity
KXZ66_RS20865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KXZ66_RS20870	COG5294	Protein conserved in bacteria
KXZ66_RS20875	COG0577	efflux transmembrane transporter activity
KXZ66_RS20880	COG1136	(ABC) transporter
KXZ66_RS20885	COG2205	protein histidine kinase activity
KXZ66_RS20890	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS20895	COG0191	fructose-bisphosphate aldolase activity
KXZ66_RS20900	COG1082	Xylose isomerase domain protein TIM barrel
KXZ66_RS20905	COG1082	Xylose isomerase domain protein TIM barrel
KXZ66_RS20910	COG0673	inositol 2-dehydrogenase activity
KXZ66_RS20915	COG2814	Major facilitator Superfamily
KXZ66_RS20920	COG1082	Xylose isomerase domain protein TIM barrel
KXZ66_RS20925	COG3962	Belongs to the TPP enzyme family
KXZ66_RS20930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KXZ66_RS20940	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS20945	COG1349	DNA-binding transcription factor activity
KXZ66_RS20950	COG0667	Aldo Keto reductase
KXZ66_RS20965	COG2814	Major facilitator Superfamily
KXZ66_RS20970	COG0326	Molecular chaperone. Has ATPase activity
KXZ66_RS20980	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS21005	COG1309	transcriptional regulator
KXZ66_RS21010	COG1012	belongs to the aldehyde dehydrogenase family
KXZ66_RS21020	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KXZ66_RS21030	COG1714	RDD family
KXZ66_RS21035	COG2311	Membrane
KXZ66_RS21040	COG1917	Cupin 2, conserved barrel domain protein
KXZ66_RS21045	COG1309	transcriptional regulator
KXZ66_RS21050	COG1028	Short-chain dehydrogenase reductase Sdr
KXZ66_RS21055	COG1846	Transcriptional regulator
KXZ66_RS21060	COG1380	Effector of murein hydrolase LrgA
KXZ66_RS21065	COG1346	cytolysis
KXZ66_RS21070	COG5039	Polysaccharide pyruvyl transferase
KXZ66_RS21075	COG1929	Belongs to the glycerate kinase type-1 family
KXZ66_RS21080	COG1802	Transcriptional regulator
KXZ66_RS21085	COG1070	Carbohydrate kinase
KXZ66_RS21090	COG2610	gluconate transmembrane transporter activity
KXZ66_RS21095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KXZ66_RS21100	COG0450	alkyl hydroperoxide reductase
KXZ66_RS21105	COG3634	alkyl hydroperoxide reductase activity
KXZ66_RS21115	COG2723	6-phospho-beta-galactosidase activity
KXZ66_RS21125	COG2188	Transcriptional regulator
KXZ66_RS21140	COG1131	(ABC) transporter
KXZ66_RS21145	COG1994	Peptidase M50
KXZ66_RS21150	COG0535	radical SAM domain protein
KXZ66_RS21160	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
KXZ66_RS21170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KXZ66_RS21175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KXZ66_RS21190	COG1063	alcohol dehydrogenase
KXZ66_RS21210	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
KXZ66_RS21215	COG0456	acetyltransferase
KXZ66_RS21220	COG0457	Tetratricopeptide repeat
KXZ66_RS21230	COG0010	Belongs to the arginase family
KXZ66_RS21235	COG0833	amino acid
KXZ66_RS21240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KXZ66_RS21245	COG3829	transcription factor binding
KXZ66_RS21260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KXZ66_RS21265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KXZ66_RS21270	COG4853	Protein conserved in bacteria
KXZ66_RS21275	COG4863	YycH protein
KXZ66_RS21280	COG5002	protein histidine kinase activity
KXZ66_RS21285	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS21315	COG0346	lactoylglutathione lyase activity
KXZ66_RS21320	COG0305	Participates in initiation and elongation during chromosome replication
KXZ66_RS21335	COG3093	addiction module antidote protein HigA
KXZ66_RS21340	COG2807	transmembrane transport
KXZ66_RS21345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KXZ66_RS21350	COG0359	binds to the 23S rRNA
KXZ66_RS21355	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KXZ66_RS21360	COG4241	membrane
KXZ66_RS21370	COG5577	PFAM Coat F domain
KXZ66_RS21375	COG1733	regulation of RNA biosynthetic process
KXZ66_RS21380	COG1227	inorganic diphosphatase activity
KXZ66_RS21395	COG2271	Major facilitator Superfamily
KXZ66_RS21410	COG4319	ketosteroid isomerase
KXZ66_RS21415	COG1357	PFAM Pentapeptide repeats (8 copies)
KXZ66_RS21420	COG2814	Major facilitator Superfamily
KXZ66_RS21425	COG0583	DNA-binding transcription factor activity
KXZ66_RS21430	COG2153	protein acetylation
KXZ66_RS21440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KXZ66_RS21445	COG1846	Transcriptional regulator
KXZ66_RS21450	COG2153	protein acetylation
KXZ66_RS21455	COG2364	Membrane
KXZ66_RS21460	COG0456	acetyltransferase
KXZ66_RS21465	COG2315	Protein conserved in bacteria
KXZ66_RS21470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KXZ66_RS21500	COG1331	Highly conserved protein containing a thioredoxin domain
KXZ66_RS21505	COG1266	CAAX protease self-immunity
KXZ66_RS21510	COG0477	Major facilitator Superfamily
KXZ66_RS21510	COG2814	Major facilitator Superfamily
KXZ66_RS21515	COG0110	maltose O-acetyltransferase activity
KXZ66_RS21520	COG0346	lactoylglutathione lyase activity
KXZ66_RS21525	COG1609	Transcriptional regulator
KXZ66_RS21530	COG0708	Exodeoxyribonuclease III
KXZ66_RS21535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KXZ66_RS21540	COG0629	single-stranded DNA binding
KXZ66_RS21545	COG0360	Binds together with S18 to 16S ribosomal RNA
KXZ66_RS21550	COG0012	GTP binding
KXZ66_RS21555	COG0243	molybdopterin cofactor binding
KXZ66_RS21560	COG4481	Protein conserved in bacteria
KXZ66_RS21565	COG3949	Membrane
KXZ66_RS21575	COG1475	DNA binding
KXZ66_RS21580	COG1192	Involved in chromosome partitioning
KXZ66_RS21590	COG1475	DNA binding
KXZ66_RS21595	COG0357	Ribosomal RNA small subunit methyltransferase G
KXZ66_RS21600	COG0445	tRNA wobble uridine modification
KXZ66_RS21605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KXZ66_RS21610	COG1847	R3H domain protein
KXZ66_RS21615	COG0706	membrane insertase activity
KXZ66_RS21620	COG0594	ribonuclease P activity
KXZ66_RS21680	COG2887	Belongs to the helicase family. UvrD subfamily
KXZ66_RS21685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KXZ66_RS21690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KXZ66_RS21695	COG0716	FMN binding
KXZ66_RS21735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KXZ66_RS21770	COG0328	RNA-DNA hybrid ribonuclease activity
KXZ66_RS21790	COG0587	DNA-directed DNA polymerase activity
KXZ66_RS21810	COG0194	GDP metabolic process
KXZ66_RS21860	COG0187	DNA topoisomerase II activity
KXZ66_RS21865	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KXZ66_RS21915	COG5444	nuclease activity
KXZ66_RS21970	COG5280	Phage tail tape measure protein TP901
KXZ66_RS21970	COG3953	SLT domain
KXZ66_RS22060	COG0457	Tetratricopeptide repeat
KXZ66_RS22080	COG1388	LysM domain
KXZ66_RS22080	COG3584	3D domain protein
KXZ66_RS22090	COG0582	viral genome integration into host DNA
KXZ66_RS22135	COG1793	dna ligase
KXZ66_RS22150	COG1525	nuclease
KXZ66_RS22250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KXZ66_RS22295	COG0457	Tetratricopeptide repeat
KXZ66_RS22305	COG2186	Transcriptional regulator
KXZ66_RS22310	COG2962	Rard protein
KXZ66_RS22315	COG1247	-acetyltransferase
KXZ66_RS22320	COG2084	Dehydrogenase
KXZ66_RS22450	COG0629	single-stranded DNA binding
KXZ66_RS22465	COG0582	viral genome integration into host DNA
KXZ66_RS22490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KXZ66_RS22510	COG1073	alpha beta
KXZ66_RS22545	COG0457	Tetratricopeptide repeat
KXZ66_RS22685	COG0745	RESPONSE REGULATOR receiver
KXZ66_RS22685	COG2972	Histidine kinase
KXZ66_RS22720	COG1714	RDD family