locus-tag	class	description
FLK61_RS00145	COG0791	NLP P60 protein
FLK61_RS00145	COG3883	PFAM NLP P60 protein
FLK61_RS00205	COG0629	single-stranded DNA binding
FLK61_RS00220	COG0582	viral genome integration into host DNA
FLK61_RS00250	COG1793	dna ligase
FLK61_RS00265	COG1525	nuclease
FLK61_RS00360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FLK61_RS00400	COG0457	Tetratricopeptide repeat
FLK61_RS00440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FLK61_RS00445	COG0592	DNA-directed DNA polymerase activity
FLK61_RS00450	COG2501	S4 domain
FLK61_RS00455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FLK61_RS00465	COG0187	DNA topoisomerase II activity
FLK61_RS00470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FLK61_RS00475	COG3437	response regulator, receiver
FLK61_RS00495	COG0517	IMP dehydrogenase activity
FLK61_RS00495	COG0516	GMP reductase activity
FLK61_RS00505	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FLK61_RS00510	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FLK61_RS00520	COG0444	Belongs to the ABC transporter superfamily
FLK61_RS00525	COG4608	Belongs to the ABC transporter superfamily
FLK61_RS00530	COG4166	transmembrane transport
FLK61_RS00535	COG0601	transmembrane transport
FLK61_RS00540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FLK61_RS00545	COG0590	tRNA wobble adenosine to inosine editing
FLK61_RS00550	COG3093	addiction module antidote protein HigA
FLK61_RS00560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FLK61_RS00565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FLK61_RS00570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FLK61_RS00605	COG1982	Orn Lys Arg decarboxylase major
FLK61_RS00610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FLK61_RS00615	COG3870	Protein conserved in bacteria
FLK61_RS00620	COG0470	DNA polymerase III
FLK61_RS00625	COG1774	PSP1 C-terminal conserved region
FLK61_RS00630	COG4467	Involved in initiation control of chromosome replication
FLK61_RS00635	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FLK61_RS00640	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FLK61_RS00645	COG2002	toxin-antitoxin pair type II binding
FLK61_RS00650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FLK61_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FLK61_RS00655	COG0084	hydrolase, TatD family'
FLK61_RS00660	COG3584	3D domain protein
FLK61_RS00660	COG3583	domain protein
FLK61_RS00670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FLK61_RS00680	COG4466	Protein conserved in bacteria
FLK61_RS00685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FLK61_RS00690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FLK61_RS00695	COG2088	sporulation resulting in formation of a cellular spore
FLK61_RS00700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FLK61_RS00705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FLK61_RS00710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FLK61_RS00715	COG0193	aminoacyl-tRNA hydrolase activity
FLK61_RS00725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FLK61_RS00730	COG2002	toxin-antitoxin pair type II binding
FLK61_RS00735	COG2244	polysaccharide biosynthetic process
FLK61_RS00740	COG3956	TIGRFAM MazG family protein
FLK61_RS00745	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FLK61_RS00765	COG1098	S1 RNA binding domain
FLK61_RS00770	COG2208	phosphoserine phosphatase activity
FLK61_RS00775	COG2304	oxidoreductase activity
FLK61_RS00780	COG0515	serine threonine protein kinase
FLK61_RS00785	COG2966	Psort location CytoplasmicMembrane, score
FLK61_RS00795	COG0037	tRNA processing
FLK61_RS00815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FLK61_RS00820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FLK61_RS00825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FLK61_RS00830	COG0512	Glutamine amidotransferase of anthranilate synthase
FLK61_RS00835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FLK61_RS00840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FLK61_RS00845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FLK61_RS00850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FLK61_RS00855	COG1396	sequence-specific DNA binding
FLK61_RS00860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FLK61_RS00955	COG3880	PFAM UvrB UvrC protein
FLK61_RS00960	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FLK61_RS00965	COG0542	response to heat
FLK61_RS00970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FLK61_RS00975	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FLK61_RS00980	COG4956	integral membrane protein (PIN domain superfamily)
FLK61_RS00985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FLK61_RS00995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FLK61_RS01000	COG1045	serine acetyltransferase
FLK61_RS01005	COG0215	cysteine-tRNA ligase activity
FLK61_RS01015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FLK61_RS01020	COG3688	RNA-binding protein containing a PIN domain
FLK61_RS01030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FLK61_RS01035	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FLK61_RS01040	COG0250	Participates in transcription elongation, termination and antitermination
FLK61_RS01045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FLK61_RS01050	COG0081	regulation of translation
FLK61_RS01055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FLK61_RS01060	COG0222	ribosome binding
FLK61_RS01065	COG2813	Specifically methylates the guanine in position
FLK61_RS01070	COG0085	RNA polymerase activity
FLK61_RS01075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FLK61_RS01080	COG1358	cellular component organization or biogenesis
FLK61_RS01085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FLK61_RS01090	COG0049	tRNA binding
FLK61_RS01095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FLK61_RS01100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FLK61_RS01115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FLK61_RS01120	COG0088	Forms part of the polypeptide exit tunnel
FLK61_RS01125	COG0089	rRNA binding
FLK61_RS01130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FLK61_RS01135	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FLK61_RS01140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FLK61_RS01145	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FLK61_RS01150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FLK61_RS01155	COG0255	Belongs to the universal ribosomal protein uL29 family
FLK61_RS01160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FLK61_RS01165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FLK61_RS01170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FLK61_RS01175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FLK61_RS01180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FLK61_RS01185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FLK61_RS01190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FLK61_RS01195	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FLK61_RS01200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FLK61_RS01205	COG1841	ribosomal large subunit assembly
FLK61_RS01215	COG0201	protein transport
FLK61_RS01220	COG0563	adenylate kinase activity
FLK61_RS01225	COG0024	Methionine aminopeptidase
FLK61_RS01230	COG2163	COG2163 Ribosomal protein L14E L6E L27E
FLK61_RS01235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FLK61_RS01240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FLK61_RS01245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FLK61_RS01250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FLK61_RS01255	COG0202	RNA polymerase activity
FLK61_RS01260	COG0203	ribosomal protein L17
FLK61_RS01270	COG1122	ATPase activity
FLK61_RS01275	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FLK61_RS01280	COG0101	tRNA pseudouridine synthase activity
FLK61_RS01285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FLK61_RS01290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FLK61_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS01300	COG3386	PFAM SMP-30 Gluconolaconase
FLK61_RS01355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FLK61_RS01385	COG2186	Transcriptional regulator
FLK61_RS01390	COG1556	Lactate utilization protein
FLK61_RS01395	COG1139	Iron-sulfur cluster binding protein
FLK61_RS01400	COG0247	lactate metabolic process
FLK61_RS01405	COG0800	Aldolase
FLK61_RS01410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FLK61_RS01415	COG2721	sulfolactate sulfo-lyase activity
FLK61_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS01425	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FLK61_RS01430	COG4753	response regulator
FLK61_RS01430	COG2207	Transcriptional regulator
FLK61_RS01435	COG2972	Histidine kinase
FLK61_RS01440	COG5578	integral membrane protein
FLK61_RS01445	COG0395	ABC-type sugar transport system, permease component
FLK61_RS01450	COG1175	transmembrane transport
FLK61_RS01455	COG1653	transport
FLK61_RS01460	COG1609	Transcriptional regulator
FLK61_RS01465	COG1904	glucuronate isomerase
FLK61_RS01470	COG0246	Mannitol dehydrogenase
FLK61_RS01475	COG0673	inositol 2-dehydrogenase activity
FLK61_RS01490	COG1349	DNA-binding transcription factor activity
FLK61_RS01505	COG3401	FG-GAP repeat protein
FLK61_RS01515	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FLK61_RS01520	COG0823	Involved in the tonB-independent uptake of proteins
FLK61_RS01530	COG1653	transport
FLK61_RS01535	COG4209	transmembrane transport
FLK61_RS01540	COG0395	ABC-type sugar transport system, permease component
FLK61_RS01545	COG2207	Transcriptional regulator
FLK61_RS01560	COG4806	L-rhamnose isomerase
FLK61_RS01565	COG1070	Carbohydrate kinase
FLK61_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS01570	COG3347	Dehydrogenase
FLK61_RS01575	COG1349	DNA-binding transcription factor activity
FLK61_RS01595	COG1063	alcohol dehydrogenase
FLK61_RS01605	COG0747	negative chemotaxis
FLK61_RS01610	COG0601	transmembrane transport
FLK61_RS01615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FLK61_RS01620	COG0444	Belongs to the ABC transporter superfamily
FLK61_RS01625	COG4608	Belongs to the ABC transporter superfamily
FLK61_RS01630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FLK61_RS01645	COG0515	serine threonine protein kinase
FLK61_RS01650	COG0745	RESPONSE REGULATOR receiver
FLK61_RS01655	COG5002	protein histidine kinase activity
FLK61_RS01680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FLK61_RS01705	COG0456	acetyltransferase
FLK61_RS01710	COG0386	Belongs to the glutathione peroxidase family
FLK61_RS01745	COG0579	oxidoreductase
FLK61_RS01750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FLK61_RS01755	COG3300	MHYT domain
FLK61_RS01755	COG5001	Diguanylate cyclase
FLK61_RS01760	COG1979	alcohol dehydrogenase
FLK61_RS01765	COG4821	SIS domain
FLK61_RS01785	COG0210	DNA helicase
FLK61_RS01790	COG0352	thiamine-phosphate diphosphorylase activity
FLK61_RS01795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FLK61_RS01805	COG2022	thiamine diphosphate biosynthetic process
FLK61_RS01810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FLK61_RS01830	COG4607	ABC-type enterochelin transport system periplasmic component
FLK61_RS01835	COG4604	ABC transporter, ATP-binding protein
FLK61_RS01840	COG4605	iron ion homeostasis
FLK61_RS01845	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FLK61_RS01855	COG1215	transferase activity, transferring glycosyl groups
FLK61_RS01860	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FLK61_RS01870	COG1902	pentaerythritol trinitrate reductase activity
FLK61_RS01880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FLK61_RS01885	COG1388	LysM domain
FLK61_RS01885	COG0791	NLP P60 protein
FLK61_RS01895	COG0673	inositol 2-dehydrogenase activity
FLK61_RS01920	COG0860	N-Acetylmuramoyl-L-alanine amidase
FLK61_RS01925	COG0489	protein tyrosine kinase activity
FLK61_RS01935	COG2194	sulfuric ester hydrolase activity
FLK61_RS01940	COG0726	polysaccharide deacetylase
FLK61_RS01990	COG1595	DNA-templated transcription, initiation
FLK61_RS01995	COG5662	AntiSigma factor
FLK61_RS02000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FLK61_RS02005	COG4856	YbbR-like protein
FLK61_RS02050	COG2801	Transposase and inactivated derivatives
FLK61_RS02055	COG0246	Mannitol dehydrogenase
FLK61_RS02060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FLK61_RS02065	COG3711	transcriptional antiterminator
FLK61_RS02075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FLK61_RS02150	COG2188	Transcriptional regulator
FLK61_RS02155	COG2190	(PTS) system
FLK61_RS02155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FLK61_RS02155	COG1263	PTS System
FLK61_RS02160	COG2723	6-phospho-beta-galactosidase activity
FLK61_RS02165	COG0717	Belongs to the dCTP deaminase family
FLK61_RS02170	COG0523	cobalamin synthesis protein
FLK61_RS02175	COG0523	cobalamin synthesis protein
FLK61_RS02195	COG2205	protein histidine kinase activity
FLK61_RS02200	COG2205	protein histidine kinase activity
FLK61_RS02210	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FLK61_RS02215	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FLK61_RS02230	COG4152	abc transporter atp-binding protein
FLK61_RS02235	COG1131	(ABC) transporter
FLK61_RS02260	COG0436	Aminotransferase
FLK61_RS02265	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FLK61_RS02270	COG0235	Class ii aldolase
FLK61_RS02275	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
FLK61_RS02280	COG1850	ribulose-bisphosphate carboxylase activity
FLK61_RS02285	COG1879	ABC-type sugar transport system periplasmic component
FLK61_RS02290	COG1129	ABC transporter
FLK61_RS02295	COG1172	Belongs to the binding-protein-dependent transport system permease family
FLK61_RS02305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FLK61_RS02315	COG5646	InterPro IPR014922
FLK61_RS02340	COG0346	lactoylglutathione lyase activity
FLK61_RS02350	COG2130	NADP-dependent
FLK61_RS02360	COG1595	DNA-templated transcription, initiation
FLK61_RS02385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FLK61_RS02390	COG2207	Transcriptional regulator
FLK61_RS02395	COG0456	acetyltransferase
FLK61_RS02415	COG0456	acetyltransferase
FLK61_RS02455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FLK61_RS02470	COG0702	epimerase
FLK61_RS02490	COG1131	(ABC) transporter
FLK61_RS02520	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FLK61_RS02525	COG1714	RDD family
FLK61_RS02540	COG0456	acetyltransferase
FLK61_RS02545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FLK61_RS02600	COG2814	Major facilitator Superfamily
FLK61_RS02625	COG0745	RESPONSE REGULATOR receiver
FLK61_RS02630	COG5002	protein histidine kinase activity
FLK61_RS02670	COG1695	Transcriptional regulator
FLK61_RS02690	COG2323	membrane
FLK61_RS02695	COG2203	Gaf domain
FLK61_RS02695	COG4585	Histidine kinase
FLK61_RS02700	COG2197	response regulator
FLK61_RS02710	COG2203	Gaf domain
FLK61_RS02710	COG5001	Diguanylate cyclase
FLK61_RS02710	COG4251	negative regulation of phosphorylation
FLK61_RS02710	COG3706	GGDEF domain
FLK61_RS02720	COG1846	Transcriptional regulator
FLK61_RS02735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FLK61_RS02760	COG1132	(ABC) transporter
FLK61_RS02770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FLK61_RS02775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FLK61_RS02780	COG2323	membrane
FLK61_RS02785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FLK61_RS02795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FLK61_RS02830	COG0778	Nitroreductase
FLK61_RS02845	COG1695	Transcriptional regulator
FLK61_RS02855	COG1741	Belongs to the pirin family
FLK61_RS02875	COG0666	response to abiotic stimulus
FLK61_RS02905	COG1131	(ABC) transporter
FLK61_RS02920	COG2203	Gaf domain
FLK61_RS02920	COG2199	diguanylate cyclase activity
FLK61_RS02940	COG1064	alcohol dehydrogenase
FLK61_RS02950	COG1464	Belongs to the NlpA lipoprotein family
FLK61_RS02955	COG2011	ABC-type metal ion transport system permease component
FLK61_RS02960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FLK61_RS02965	COG5583	Uncharacterized small protein (DUF2292)
FLK61_RS02975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FLK61_RS03000	COG2801	Transposase and inactivated derivatives
FLK61_RS03015	COG2340	Cysteine-rich secretory protein family
FLK61_RS03035	COG3764	Sortase (surface protein transpeptidase)
FLK61_RS03055	COG1069	ribulokinase activity
FLK61_RS03065	COG1653	transport
FLK61_RS03070	COG1175	transmembrane transport
FLK61_RS03075	COG0395	ABC-type sugar transport system, permease component
FLK61_RS03085	COG3534	alpha-L-arabinofuranosidase
FLK61_RS03090	COG1609	Transcriptional regulator
FLK61_RS03100	COG0673	inositol 2-dehydrogenase activity
FLK61_RS03105	COG0747	negative chemotaxis
FLK61_RS03110	COG0501	Belongs to the peptidase M48B family
FLK61_RS03120	COG0346	lactoylglutathione lyase activity
FLK61_RS03130	COG2391	methyltransferase activity
FLK61_RS03170	COG0076	glutamate decarboxylase activity
FLK61_RS03175	COG0702	epimerase
FLK61_RS03210	COG1302	Protein conserved in bacteria
FLK61_RS03215	COG0840	transmembrane signaling receptor activity
FLK61_RS03240	COG0582	viral genome integration into host DNA
FLK61_RS03250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FLK61_RS03255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FLK61_RS03260	COG1120	ATPase activity
FLK61_RS03275	COG0488	(ABC) transporter
FLK61_RS03280	COG2746	aminoglycoside 3-N-acetyltransferase activity
FLK61_RS03300	COG0583	DNA-binding transcription factor activity
FLK61_RS03310	COG2226	methyltransferase
FLK61_RS03315	COG1854	S-ribosylhomocysteine lyase activity
FLK61_RS03320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FLK61_RS03325	COG0626	cystathionine gamma-synthase activity
FLK61_RS03335	COG1131	(ABC) transporter
FLK61_RS03345	COG0584	glycerophosphoryl diester phosphodiesterase
FLK61_RS03350	COG3842	ATPase activity
FLK61_RS03355	COG1175	transmembrane transport
FLK61_RS03360	COG0395	ABC-type sugar transport system, permease component
FLK61_RS03370	COG2188	Transcriptional regulator
FLK61_RS03385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FLK61_RS03390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FLK61_RS03395	COG4152	abc transporter atp-binding protein
FLK61_RS03405	COG0346	lactoylglutathione lyase activity
FLK61_RS03410	COG0693	protein deglycase activity
FLK61_RS03415	COG2860	membrane
FLK61_RS03430	COG1272	protein, Hemolysin III
FLK61_RS03435	COG1295	ribonuclease BN
FLK61_RS03450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FLK61_RS03490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FLK61_RS03495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FLK61_RS03500	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FLK61_RS03505	COG4876	unkown
FLK61_RS03530	COG2514	catechol 2,3-dioxygenase activity
FLK61_RS03535	COG1227	inorganic diphosphatase activity
FLK61_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS03545	COG0765	amino acid transport
FLK61_RS03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FLK61_RS03560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FLK61_RS03565	COG0745	RESPONSE REGULATOR receiver
FLK61_RS03570	COG5002	protein histidine kinase activity
FLK61_RS03570	COG3850	Histidine kinase
FLK61_RS03575	COG3212	peptidase
FLK61_RS03580	COG3212	peptidase
FLK61_RS03600	COG1454	alcohol dehydrogenase
FLK61_RS03620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FLK61_RS03630	COG0860	N-Acetylmuramoyl-L-alanine amidase
FLK61_RS03655	COG2814	Major facilitator Superfamily
FLK61_RS03675	COG1609	Transcriptional regulator
FLK61_RS03685	COG0673	inositol 2-dehydrogenase activity
FLK61_RS03690	COG0673	inositol 2-dehydrogenase activity
FLK61_RS03695	COG1082	Xylose isomerase domain protein TIM barrel
FLK61_RS03700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FLK61_RS03700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FLK61_RS03700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FLK61_RS03705	COG1105	Belongs to the carbohydrate kinase PfkB family
FLK61_RS03710	COG1349	DNA-binding transcription factor activity
FLK61_RS03720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FLK61_RS03725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FLK61_RS03730	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FLK61_RS03735	COG1940	carbohydrate kinase activity
FLK61_RS03740	COG2202	Pas domain
FLK61_RS03740	COG1366	Belongs to the anti-sigma-factor antagonist family
FLK61_RS03745	COG0753	catalase activity
FLK61_RS03770	COG0589	response to stress
FLK61_RS03775	COG0659	secondary active sulfate transmembrane transporter activity
FLK61_RS03780	COG0561	phosphatase activity
FLK61_RS03785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FLK61_RS03790	COG0363	glucosamine-6-phosphate deaminase activity
FLK61_RS03815	COG1366	Belongs to the anti-sigma-factor antagonist family
FLK61_RS03820	COG0840	transmembrane signaling receptor activity
FLK61_RS03820	COG5278	phosphoserine phosphatase activity
FLK61_RS03835	COG0861	Integral membrane protein TerC family
FLK61_RS03840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FLK61_RS03845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FLK61_RS03870	COG1595	DNA-templated transcription, initiation
FLK61_RS03880	COG1132	(ABC) transporter
FLK61_RS03885	COG3829	transcription factor binding
FLK61_RS03890	COG1012	belongs to the aldehyde dehydrogenase family
FLK61_RS03895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FLK61_RS03900	COG0506	proline dehydrogenase activity
FLK61_RS03910	COG2239	Acts as a magnesium transporter
FLK61_RS03915	COG3842	ATPase activity
FLK61_RS03925	COG1178	ABC-type Fe3 transport system permease component
FLK61_RS03930	COG0705	Rhomboid family
FLK61_RS03940	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FLK61_RS03950	COG0864	Transcriptional regulator
FLK61_RS03955	COG2337	Toxic component of a toxin-antitoxin (TA) module
FLK61_RS03960	COG1366	Belongs to the anti-sigma-factor antagonist family
FLK61_RS03965	COG1366	Belongs to the anti-sigma-factor antagonist family
FLK61_RS03970	COG2172	sigma factor antagonist activity
FLK61_RS03975	COG2208	phosphoserine phosphatase activity
FLK61_RS03980	COG1366	Belongs to the anti-sigma-factor antagonist family
FLK61_RS03985	COG2172	sigma factor antagonist activity
FLK61_RS03990	COG1191	sigma factor activity
FLK61_RS04000	COG2183	response to ionizing radiation
FLK61_RS04080	COG0626	cystathionine gamma-synthase activity
FLK61_RS04085	COG0802	atpase or kinase
FLK61_RS04090	COG1214	PFAM Peptidase M22, glycoprotease
FLK61_RS04095	COG0456	acetyltransferase
FLK61_RS04125	COG0488	(ABC) transporter
FLK61_RS04130	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FLK61_RS04155	COG1396	sequence-specific DNA binding
FLK61_RS04195	COG0305	Participates in initiation and elongation during chromosome replication
FLK61_RS04295	COG0582	viral genome integration into host DNA
FLK61_RS04375	COG0739	heme binding
FLK61_RS04435	COG4974	Belongs to the 'phage' integrase family
FLK61_RS04465	COG2814	Major facilitator Superfamily
FLK61_RS04475	COG1266	CAAX protease self-immunity
FLK61_RS04485	COG0459	protein refolding
FLK61_RS04500	COG0697	spore germination
FLK61_RS04535	COG5578	integral membrane protein
FLK61_RS04545	COG0395	ABC-type sugar transport system, permease component
FLK61_RS04555	COG0745	RESPONSE REGULATOR receiver
FLK61_RS04555	COG2972	Histidine kinase
FLK61_RS04560	COG2207	Transcriptional regulator
FLK61_RS04560	COG4753	response regulator
FLK61_RS04585	COG3708	Transcriptional regulator
FLK61_RS04585	COG2207	Transcriptional regulator
FLK61_RS04615	COG0583	DNA-binding transcription factor activity
FLK61_RS04640	COG1309	transcriptional regulator
FLK61_RS04675	COG0596	Alpha beta hydrolase
FLK61_RS04720	COG2207	Transcriptional regulator
FLK61_RS04720	COG3708	Transcriptional regulator
FLK61_RS04755	COG0604	alcohol dehydrogenase
FLK61_RS04770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FLK61_RS04780	COG1473	amidohydrolase
FLK61_RS04785	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FLK61_RS04800	COG3328	transposase activity
FLK61_RS04810	COG2409	Drug exporters of the RND superfamily
FLK61_RS04830	COG0492	ferredoxin-NADP+ reductase activity
FLK61_RS04845	COG4585	Histidine kinase
FLK61_RS04850	COG2197	response regulator
FLK61_RS04855	COG1131	(ABC) transporter
FLK61_RS04870	COG2357	RelA SpoT domain protein
FLK61_RS04875	COG0662	Cupin 2, conserved barrel domain protein
FLK61_RS04885	COG3706	GGDEF domain
FLK61_RS04890	COG1181	Belongs to the D-alanine--D-alanine ligase family
FLK61_RS04895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FLK61_RS04905	COG2190	(PTS) system
FLK61_RS04905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FLK61_RS04905	COG1263	PTS System
FLK61_RS04910	COG2723	6-phospho-beta-galactosidase activity
FLK61_RS04915	COG2723	6-phospho-beta-galactosidase activity
FLK61_RS04920	COG3711	transcriptional antiterminator
FLK61_RS04925	COG0194	GDP metabolic process
FLK61_RS04930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FLK61_RS04940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FLK61_RS04950	COG0840	transmembrane signaling receptor activity
FLK61_RS04965	COG1388	LysM domain
FLK61_RS04965	COG0791	NLP P60 protein
FLK61_RS04970	COG5002	protein histidine kinase activity
FLK61_RS04970	COG2198	Histidine kinase
FLK61_RS04970	COG0784	Response regulator, receiver
FLK61_RS04975	COG0745	RESPONSE REGULATOR receiver
FLK61_RS05010	COG0500	methyltransferase
FLK61_RS05015	COG5002	protein histidine kinase activity
FLK61_RS05020	COG0596	Alpha beta hydrolase
FLK61_RS05030	COG0110	maltose O-acetyltransferase activity
FLK61_RS05045	COG2801	Transposase and inactivated derivatives
FLK61_RS05050	COG0737	Belongs to the 5'-nucleotidase family
FLK61_RS05065	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FLK61_RS05065	COG0456	acetyltransferase
FLK61_RS05070	COG4988	ABC transporter
FLK61_RS05075	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FLK61_RS05085	COG1595	DNA-templated transcription, initiation
FLK61_RS05100	COG1131	(ABC) transporter
FLK61_RS05130	COG0714	Associated with various cellular activities
FLK61_RS05135	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
FLK61_RS05140	COG1305	Transglutaminase-like
FLK61_RS05145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FLK61_RS05145	COG0519	Catalyzes the synthesis of GMP from XMP
FLK61_RS05155	COG3655	Transcriptional regulator
FLK61_RS05165	COG2252	PERMEase
FLK61_RS05170	COG3424	synthase
FLK61_RS05175	COG1755	Isoprenylcysteine carboxyl methyltransferase
FLK61_RS05195	COG1506	peptidase
FLK61_RS05195	COG0823	Involved in the tonB-independent uptake of proteins
FLK61_RS05195	COG4946	Tricorn protease homolog
FLK61_RS05205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FLK61_RS05210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FLK61_RS05215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FLK61_RS05220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FLK61_RS05225	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FLK61_RS05230	COG0047	phosphoribosylformylglycinamidine synthase activity
FLK61_RS05235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FLK61_RS05240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FLK61_RS05245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FLK61_RS05250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FLK61_RS05260	COG0151	Belongs to the GarS family
FLK61_RS05265	COG0405	Gamma-glutamyltransferase
FLK61_RS05270	COG1181	Belongs to the D-alanine--D-alanine ligase family
FLK61_RS05285	COG4721	ABC-type cobalt transport system, permease component
FLK61_RS05290	COG4172	Belongs to the ABC transporter superfamily
FLK61_RS05295	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FLK61_RS05300	COG1253	flavin adenine dinucleotide binding
FLK61_RS05310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FLK61_RS05320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FLK61_RS05325	COG1470	cell adhesion involved in biofilm formation
FLK61_RS05330	COG4496	protein, YerC YecD
FLK61_RS05335	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FLK61_RS05340	COG0210	DNA helicase
FLK61_RS05345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FLK61_RS05350	COG4851	CamS sex pheromone cAM373 precursor
FLK61_RS05360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FLK61_RS05365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FLK61_RS05370	COG0154	amidase activity
FLK61_RS05390	COG0714	Associated with various cellular activities
FLK61_RS05405	COG1597	lipid kinase activity
FLK61_RS05415	COG1131	(ABC) transporter
FLK61_RS05445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FLK61_RS05450	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FLK61_RS05460	COG2390	Transcriptional regulator
FLK61_RS05480	COG3012	SEC-C Motif Domain Protein
FLK61_RS05480	COG1405	negative regulation of cell septum assembly
FLK61_RS05485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FLK61_RS05490	COG0667	Aldo Keto reductase
FLK61_RS05515	COG1361	Conserved repeat domain
FLK61_RS05520	COG0596	Alpha beta hydrolase
FLK61_RS05550	COG2808	Putative FMN-binding domain
FLK61_RS05580	COG1454	alcohol dehydrogenase
FLK61_RS05600	COG0028	Belongs to the TPP enzyme family
FLK61_RS05610	COG0456	acetyltransferase
FLK61_RS05610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FLK61_RS05645	COG0446	pyridine nucleotide-disulphide oxidoreductase
FLK61_RS05660	COG2226	methyltransferase
FLK61_RS05685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FLK61_RS05685	COG1263	PTS System
FLK61_RS05690	COG1621	beta-fructofuranosidase activity
FLK61_RS05695	COG1609	Transcriptional regulator
FLK61_RS05700	COG0791	NLP P60 protein
FLK61_RS05710	COG2176	DNA-directed DNA polymerase activity
FLK61_RS05730	COG1404	Belongs to the peptidase S8 family
FLK61_RS05745	COG1376	ErfK ybiS ycfS ynhG family protein
FLK61_RS05785	COG4895	conserved protein (DUF2196)
FLK61_RS05795	COG0840	transmembrane signaling receptor activity
FLK61_RS05800	COG2153	protein acetylation
FLK61_RS05805	COG5001	Diguanylate cyclase
FLK61_RS05810	COG0366	Alpha amylase catalytic
FLK61_RS05820	COG1132	(ABC) transporter
FLK61_RS05825	COG1132	(ABC) transporter
FLK61_RS05835	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FLK61_RS05840	COG0840	transmembrane signaling receptor activity
FLK61_RS05845	COG0352	thiamine-phosphate diphosphorylase activity
FLK61_RS05850	COG0351	phosphomethylpyrimidine kinase
FLK61_RS05855	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FLK61_RS05860	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
FLK61_RS05870	COG0514	ATP-dependent DNA helicase (RecQ)
FLK61_RS05875	COG0346	lactoylglutathione lyase activity
FLK61_RS05880	COG0400	carboxylic ester hydrolase activity
FLK61_RS05885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FLK61_RS05890	COG2203	Gaf domain
FLK61_RS05890	COG3706	GGDEF domain
FLK61_RS05890	COG4251	negative regulation of phosphorylation
FLK61_RS05890	COG5001	Diguanylate cyclase
FLK61_RS05895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FLK61_RS05905	COG0488	(ABC) transporter
FLK61_RS05920	COG0628	permease
FLK61_RS05925	COG1216	Glycosyl transferase, family 2
FLK61_RS05930	COG1597	lipid kinase activity
FLK61_RS05940	COG0288	reversible hydration of carbon dioxide
FLK61_RS05945	COG1077	Cell shape determining protein MreB Mrl
FLK61_RS05965	COG0534	Mate efflux family protein
FLK61_RS05970	COG1994	Peptidase M50
FLK61_RS05975	COG1012	belongs to the aldehyde dehydrogenase family
FLK61_RS05995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FLK61_RS06015	COG1254	Belongs to the acylphosphatase family
FLK61_RS06020	COG3835	regulator
FLK61_RS06025	COG2610	gluconate transmembrane transporter activity
FLK61_RS06030	COG1929	Belongs to the glycerate kinase type-1 family
FLK61_RS06050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FLK61_RS06055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FLK61_RS06070	COG0477	Major facilitator Superfamily
FLK61_RS06080	COG0534	Mate efflux family protein
FLK61_RS06095	COG0535	radical SAM domain protein
FLK61_RS06105	COG0406	alpha-ribazole phosphatase activity
FLK61_RS06120	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FLK61_RS06125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FLK61_RS06135	COG4512	PFAM Accessory gene regulator B
FLK61_RS06145	COG3852	Histidine kinase
FLK61_RS06150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FLK61_RS06155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FLK61_RS06195	COG1120	ATPase activity
FLK61_RS06205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FLK61_RS06210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FLK61_RS06215	COG0366	Alpha amylase catalytic
FLK61_RS06220	COG2188	Transcriptional regulator
FLK61_RS06235	COG1090	epimerase
FLK61_RS06240	COG2137	regulation of response to DNA damage stimulus
FLK61_RS06255	COG1988	membrane-bound metal-dependent
FLK61_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS06285	COG2059	Chromate
FLK61_RS06290	COG2059	Chromate
FLK61_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS06310	COG3557	Belongs to the UPF0374 family
FLK61_RS06315	COG1132	(ABC) transporter
FLK61_RS06320	COG4129	membrane
FLK61_RS06325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FLK61_RS06330	COG4555	ABC transporter
FLK61_RS06350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FLK61_RS06365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FLK61_RS06370	COG3870	Protein conserved in bacteria
FLK61_RS06375	COG0735	belongs to the Fur family
FLK61_RS06480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FLK61_RS06505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FLK61_RS06510	COG2766	serine protein kinase
FLK61_RS06520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FLK61_RS06525	COG2718	Belongs to the UPF0229 family
FLK61_RS06540	COG0702	epimerase
FLK61_RS06550	COG3546	catalase activity
FLK61_RS06555	COG4191	Histidine kinase
FLK61_RS06565	COG3192	ethanolamine utilization protein
FLK61_RS06570	COG0655	NAD(P)H dehydrogenase (quinone) activity
FLK61_RS06605	COG0395	ABC-type sugar transport system, permease component
FLK61_RS06610	COG0840	transmembrane signaling receptor activity
FLK61_RS06615	COG2201	protein-glutamate methylesterase activity
FLK61_RS06650	COG3153	acetyltransferase
FLK61_RS06650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FLK61_RS06655	COG2017	converts alpha-aldose to the beta-anomer
FLK61_RS06660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FLK61_RS06665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FLK61_RS06670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FLK61_RS06675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FLK61_RS06680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FLK61_RS06690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FLK61_RS06695	COG0066	3-isopropylmalate dehydratase activity
FLK61_RS06700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FLK61_RS06705	COG0473	3-isopropylmalate dehydrogenase activity
FLK61_RS06710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FLK61_RS06715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FLK61_RS06720	COG0440	acetolactate synthase activity
FLK61_RS06725	COG0028	Belongs to the TPP enzyme family
FLK61_RS06735	COG3620	sequence-specific DNA binding
FLK61_RS06740	COG2719	SpoVR family
FLK61_RS06745	COG0398	Pfam SNARE associated Golgi protein
FLK61_RS06765	COG0667	Aldo Keto reductase
FLK61_RS06775	COG1388	LysM domain
FLK61_RS06775	COG3584	3D domain protein
FLK61_RS06790	COG0024	Methionine aminopeptidase
FLK61_RS06800	COG1366	Belongs to the anti-sigma-factor antagonist family
FLK61_RS06805	COG2340	Cysteine-rich secretory protein family
FLK61_RS06820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FLK61_RS06830	COG2313	pseudouridylate synthase activity
FLK61_RS06840	COG5609	conserved protein (DUF2294)
FLK61_RS06845	COG1263	PTS System
FLK61_RS06845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FLK61_RS06855	COG1131	(ABC) transporter
FLK61_RS06860	COG1725	Transcriptional regulator
FLK61_RS06890	COG1294	oxidase, subunit
FLK61_RS06895	COG1271	oxidase subunit
FLK61_RS06900	COG2197	response regulator
FLK61_RS06905	COG1132	(ABC) transporter
FLK61_RS06910	COG1132	(ABC) transporter
FLK61_RS06915	COG0702	epimerase
FLK61_RS06920	COG1960	acyl-CoA dehydrogenase activity
FLK61_RS06925	COG0439	Biotin carboxylase
FLK61_RS06930	COG0511	ligase activity, forming carbon-carbon bonds
FLK61_RS06935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FLK61_RS06940	COG1024	Enoyl-CoA hydratase
FLK61_RS06945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FLK61_RS06950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FLK61_RS06965	COG3842	ATPase activity
FLK61_RS06970	COG2508	Transcriptional regulator
FLK61_RS06980	COG4399	Belongs to the UPF0754 family
FLK61_RS06990	COG0561	phosphatase activity
FLK61_RS07005	COG0420	3'-5' exonuclease activity
FLK61_RS07010	COG4717	serine-type aminopeptidase activity
FLK61_RS07015	COG0745	RESPONSE REGULATOR receiver
FLK61_RS07020	COG2770	Histidine kinase
FLK61_RS07020	COG2205	protein histidine kinase activity
FLK61_RS07025	COG3481	metal-dependent phosphohydrolase, HD sub domain
FLK61_RS07035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FLK61_RS07065	COG1846	Transcriptional regulator
FLK61_RS07070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FLK61_RS07075	COG0537	adenosine 5'-monophosphoramidase activity
FLK61_RS07080	COG1131	(ABC) transporter
FLK61_RS07085	COG4473	ABC transporter
FLK61_RS07090	COG1473	amidohydrolase
FLK61_RS07095	COG0785	Cytochrome C biogenesis protein
FLK61_RS07100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FLK61_RS07105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FLK61_RS07120	COG0010	Belongs to the arginase family
FLK61_RS07130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FLK61_RS07135	COG4492	Belongs to the UPF0735 family
FLK61_RS07140	COG0077	Prephenate dehydratase
FLK61_RS07155	COG0217	transcriptional regulatory protein
FLK61_RS07165	COG0632	four-way junction helicase activity
FLK61_RS07185	COG0343	queuine tRNA-ribosyltransferase activity
FLK61_RS07190	COG1862	Preprotein translocase
FLK61_RS07205	COG2323	membrane
FLK61_RS07210	COG2244	polysaccharide biosynthetic process
FLK61_RS07225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FLK61_RS07225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FLK61_RS07230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FLK61_RS07230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FLK61_RS07235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FLK61_RS07240	COG5416	Lipopolysaccharide assembly protein A domain
FLK61_RS07245	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FLK61_RS07245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FLK61_RS07250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FLK61_RS07255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FLK61_RS07260	COG1490	D-aminoacyl-tRNA deacylase activity
FLK61_RS07265	COG0124	histidyl-tRNA synthetase
FLK61_RS07270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FLK61_RS07285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FLK61_RS07290	COG2364	Membrane
FLK61_RS07295	COG1959	2 iron, 2 sulfur cluster binding
FLK61_RS07300	COG1104	cysteine desulfurase activity
FLK61_RS07305	COG0482	sulfurtransferase activity
FLK61_RS07315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FLK61_RS07330	COG0628	permease
FLK61_RS07340	COG4472	Bacterial protein of unknown function (DUF965)
FLK61_RS07345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FLK61_RS07350	COG3906	Belongs to the UPF0473 family
FLK61_RS07360	COG4122	O-methyltransferase activity
FLK61_RS07365	COG0572	uridine kinase
FLK61_RS07370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FLK61_RS07385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FLK61_RS07395	COG0823	Involved in the tonB-independent uptake of proteins
FLK61_RS07395	COG4946	Tricorn protease homolog
FLK61_RS07395	COG1506	peptidase
FLK61_RS07400	COG0803	Belongs to the bacterial solute-binding protein 9 family
FLK61_RS07410	COG0667	Aldo Keto reductase
FLK61_RS07415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FLK61_RS07420	COG0656	L-ascorbic acid biosynthetic process
FLK61_RS07440	COG0697	spore germination
FLK61_RS07445	COG0095	Lipoate-protein ligase
FLK61_RS07460	COG3620	sequence-specific DNA binding
FLK61_RS07460	COG0617	tRNA 3'-terminal CCA addition
FLK61_RS07460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FLK61_RS07510	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FLK61_RS07515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FLK61_RS07525	COG1534	Rna-binding protein
FLK61_RS07530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FLK61_RS07535	COG1713	HD superfamily hydrolase involved in NAD metabolism
FLK61_RS07540	COG0799	negative regulation of ribosome biogenesis
FLK61_RS07545	COG2226	methyltransferase
FLK61_RS07550	COG1555	photosystem II stabilization
FLK61_RS07550	COG1596	polysaccharide export
FLK61_RS07555	COG2131	deaminase
FLK61_RS07560	COG0658	competence protein
FLK61_RS07560	COG2333	competence protein COMEC
FLK61_RS07570	COG1466	dna polymerase III delta subunit
FLK61_RS07580	COG0268	Binds directly to 16S ribosomal RNA
FLK61_RS07590	COG0860	N-Acetylmuramoyl-L-alanine amidase
FLK61_RS07600	COG0481	GTPase activity
FLK61_RS07605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FLK61_RS07610	COG1420	regulation of RNA biosynthetic process
FLK61_RS07615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FLK61_RS07620	COG0443	Heat shock 70 kDa protein
FLK61_RS07625	COG0484	heat shock protein binding
FLK61_RS07630	COG2264	protein methyltransferase activity
FLK61_RS07635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FLK61_RS07640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FLK61_RS07645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FLK61_RS07650	COG1610	YqeY-like protein
FLK61_RS07660	COG1030	water channel activity
FLK61_RS07665	COG4864	UPF0365 protein
FLK61_RS07685	COG1702	phosphate starvation-inducible protein PhoH
FLK61_RS07690	COG1480	7TM receptor with intracellular HD hydrolase
FLK61_RS07695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FLK61_RS07700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FLK61_RS07705	COG0295	cytidine deaminase activity
FLK61_RS07710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FLK61_RS07720	COG1381	Involved in DNA repair and RecF pathway recombination
FLK61_RS07725	COG0752	glycyl-tRNA synthetase alpha subunit
FLK61_RS07730	COG0751	glycine-tRNA ligase activity
FLK61_RS07735	COG0517	IMP dehydrogenase activity
FLK61_RS07740	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FLK61_RS07745	COG1671	Belongs to the UPF0178 family
FLK61_RS07750	COG0358	DNA primase activity
FLK61_RS07755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FLK61_RS07765	COG0584	glycerophosphoryl diester phosphodiesterase
FLK61_RS07780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FLK61_RS07785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FLK61_RS07790	COG1329	Transcriptional regulator
FLK61_RS07795	COG0513	Belongs to the DEAD box helicase family
FLK61_RS07800	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FLK61_RS07810	COG1121	(ABC) transporter
FLK61_RS07815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FLK61_RS07825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FLK61_RS07835	COG1121	(ABC) transporter
FLK61_RS07840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FLK61_RS07845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FLK61_RS07850	COG0735	belongs to the Fur family
FLK61_RS07855	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
FLK61_RS07860	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FLK61_RS07870	COG4086	secreted protein
FLK61_RS07890	COG1396	sequence-specific DNA binding
FLK61_RS07930	COG5521	maltodextrose utilization protein MalA
FLK61_RS07955	COG4918	Iron-sulphur cluster biosynthesis
FLK61_RS07960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FLK61_RS07970	COG0768	penicillin binding
FLK61_RS07990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FLK61_RS07995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FLK61_RS08000	COG1836	PFAM Integral membrane protein DUF92
FLK61_RS08015	COG0705	Rhomboid family
FLK61_RS08015	COG0457	Tetratricopeptide repeat
FLK61_RS08020	COG0697	spore germination
FLK61_RS08035	COG1940	carbohydrate kinase activity
FLK61_RS08055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FLK61_RS08065	COG4980	gas vesicle protein
FLK61_RS08070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FLK61_RS08075	COG1459	type II secretion system
FLK61_RS08080	COG4537	Required for transformation and DNA binding
FLK61_RS08105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FLK61_RS08120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FLK61_RS08125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FLK61_RS08130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FLK61_RS08135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FLK61_RS08140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FLK61_RS08145	COG0095	Lipoate-protein ligase
FLK61_RS08150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FLK61_RS08165	COG1752	Esterase of the alpha-beta hydrolase superfamily
FLK61_RS08185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FLK61_RS08190	COG0006	proline dipeptidase activity
FLK61_RS08195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FLK61_RS08200	COG3854	ATPases associated with a variety of cellular activities
FLK61_RS08245	COG0511	ligase activity, forming carbon-carbon bonds
FLK61_RS08250	COG0439	Biotin carboxylase
FLK61_RS08255	COG1302	Protein conserved in bacteria
FLK61_RS08260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FLK61_RS08270	COG1570	exodeoxyribonuclease VII activity
FLK61_RS08275	COG1722	exodeoxyribonuclease VII activity
FLK61_RS08280	COG0142	geranyltranstransferase activity
FLK61_RS08290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FLK61_RS08295	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FLK61_RS08300	COG1438	arginine binding
FLK61_RS08305	COG0497	DNA recombination
FLK61_RS08310	COG0750	zinc metalloprotease
FLK61_RS08315	COG0745	RESPONSE REGULATOR receiver
FLK61_RS08325	COG3290	protein histidine kinase activity
FLK61_RS08325	COG3829	transcription factor binding
FLK61_RS08330	COG0280	phosphate acetyltransferase
FLK61_RS08340	COG3426	butyrate kinase activity
FLK61_RS08345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FLK61_RS08350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FLK61_RS08355	COG0022	dehydrogenase e1 component
FLK61_RS08360	COG0508	dehydrogenase complex catalyzes the overall conversion of
FLK61_RS08385	COG4129	membrane
FLK61_RS08395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FLK61_RS08395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FLK61_RS08400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FLK61_RS08400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FLK61_RS08405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FLK61_RS08410	COG2195	Cleaves the N-terminal amino acid of tripeptides
FLK61_RS08420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FLK61_RS08430	COG2257	FlhB HrpN YscU SpaS Family
FLK61_RS08445	COG1728	Protein conserved in bacteria
FLK61_RS08455	COG0517	IMP dehydrogenase activity
FLK61_RS08460	COG4187	Peptidase family M20/M25/M40
FLK61_RS08465	COG0789	Transcriptional regulator
FLK61_RS08475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FLK61_RS08480	COG0300	oxidoreductase activity
FLK61_RS08490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FLK61_RS08500	COG0367	asparagine synthase
FLK61_RS08515	COG1562	ergosterol biosynthetic process
FLK61_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS08545	COG0561	phosphatase activity
FLK61_RS08550	COG2190	(PTS) system
FLK61_RS08555	COG1968	undecaprenyl-diphosphatase activity
FLK61_RS08565	COG0667	Aldo Keto reductase
FLK61_RS08570	COG0494	nUDIX hydrolase
FLK61_RS08575	COG1300	Membrane
FLK61_RS08580	COG0735	belongs to the Fur family
FLK61_RS08590	COG4974	Belongs to the 'phage' integrase family
FLK61_RS08605	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FLK61_RS08615	COG1686	Belongs to the peptidase S11 family
FLK61_RS08620	COG1366	Belongs to the anti-sigma-factor antagonist family
FLK61_RS08625	COG2172	sigma factor antagonist activity
FLK61_RS08635	COG0697	spore germination
FLK61_RS08640	COG0019	diaminopimelate decarboxylase activity
FLK61_RS08645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FLK61_RS08650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FLK61_RS08650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FLK61_RS08655	COG0307	riboflavin synthase, alpha
FLK61_RS08660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FLK61_RS08660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FLK61_RS08665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FLK61_RS08670	COG1547	Domain of unknown function (DUF309)
FLK61_RS08675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FLK61_RS08680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FLK61_RS08685	COG1012	belongs to the aldehyde dehydrogenase family
FLK61_RS08705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FLK61_RS08715	COG1686	Belongs to the peptidase S11 family
FLK61_RS08720	COG2715	membrane protein required for spore maturation
FLK61_RS08725	COG0700	Nucleoside recognition
FLK61_RS08730	COG1187	pseudouridine synthase activity
FLK61_RS08735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FLK61_RS08740	COG1333	cytochrome c biogenesis protein
FLK61_RS08745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FLK61_RS08750	COG0745	RESPONSE REGULATOR receiver
FLK61_RS08755	COG5002	protein histidine kinase activity
FLK61_RS08760	COG2096	Adenosyltransferase
FLK61_RS08770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FLK61_RS08775	COG1141	Ferredoxin
FLK61_RS08785	COG0514	ATP-dependent DNA helicase (RecQ)
FLK61_RS08790	COG1266	CAAX protease self-immunity
FLK61_RS08805	COG1408	metallophosphoesterase
FLK61_RS08820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FLK61_RS08825	COG0492	ferredoxin-NADP+ reductase activity
FLK61_RS08830	COG0252	asparaginase activity
FLK61_RS08835	COG2339	peptidase activity
FLK61_RS08845	COG3409	Peptidoglycan-binding domain 1 protein
FLK61_RS08845	COG3773	Cell wall hydrolase
FLK61_RS08850	COG2959	enzyme of heme biosynthesis
FLK61_RS08860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FLK61_RS08865	COG0204	Acyl-transferase
FLK61_RS08875	COG1304	FMN binding
FLK61_RS08885	COG1160	GTP binding
FLK61_RS08890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FLK61_RS08895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FLK61_RS08915	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FLK61_RS08925	COG0302	gtp cyclohydrolase
FLK61_RS08935	COG0142	geranyltranstransferase activity
FLK61_RS08940	COG2226	methyltransferase
FLK61_RS08945	COG0109	protoheme IX farnesyltransferase activity
FLK61_RS08950	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FLK61_RS08955	COG0142	geranyltranstransferase activity
FLK61_RS08960	COG0105	UTP biosynthetic process
FLK61_RS08965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FLK61_RS08970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FLK61_RS08975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FLK61_RS08985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FLK61_RS08990	COG0134	indole-3-glycerol-phosphate synthase activity
FLK61_RS08995	COG0133	tryptophan synthase activity
FLK61_RS09000	COG0159	tryptophan synthase activity
FLK61_RS09005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FLK61_RS09010	COG0287	Prephenate dehydrogenase
FLK61_RS09015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FLK61_RS09020	COG0457	Tetratricopeptide repeat
FLK61_RS09025	COG5582	Belongs to the UPF0302 family
FLK61_RS09035	COG0723	plastoquinol--plastocyanin reductase activity
FLK61_RS09040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FLK61_RS09045	COG2010	Cytochrome c
FLK61_RS09045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FLK61_RS09050	COG4347	Protein of unknown function (DUF1405)
FLK61_RS09060	COG2738	Putative neutral zinc metallopeptidase
FLK61_RS09065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FLK61_RS09070	COG1694	Mazg nucleotide pyrophosphohydrolase
FLK61_RS09075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FLK61_RS09080	COG1803	Methylglyoxal synthase
FLK61_RS09085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FLK61_RS09090	COG0438	transferase activity, transferring glycosyl groups
FLK61_RS09100	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FLK61_RS09100	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FLK61_RS09105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FLK61_RS09110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FLK61_RS09115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FLK61_RS09120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FLK61_RS09120	COG1199	ATP-dependent helicase activity
FLK61_RS09125	COG0402	S-adenosylhomocysteine deaminase activity
FLK61_RS09145	COG0017	Asparaginyl-tRNA synthetase
FLK61_RS09150	COG3935	DnaD domain protein
FLK61_RS09155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FLK61_RS09165	COG4499	WXG100 protein secretion system (Wss), protein YukC
FLK61_RS09165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FLK61_RS09170	COG3331	DNA recombination
FLK61_RS09195	COG1335	isochorismatase
FLK61_RS09205	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FLK61_RS09210	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FLK61_RS09215	COG0492	ferredoxin-NADP+ reductase activity
FLK61_RS09215	COG3118	belongs to the thioredoxin family
FLK61_RS09225	COG1413	lyase activity
FLK61_RS09235	COG3402	PFAM membrane-flanked domain
FLK61_RS09240	COG3428	Bacterial PH domain
FLK61_RS09250	COG1191	sigma factor activity
FLK61_RS09285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FLK61_RS09290	COG0805	protein transport
FLK61_RS09295	COG1428	Deoxynucleoside kinase
FLK61_RS09300	COG1428	Deoxynucleoside kinase
FLK61_RS09310	COG4667	esterase of the alpha-beta hydrolase superfamily
FLK61_RS09315	COG2814	Major facilitator Superfamily
FLK61_RS09330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FLK61_RS09335	COG0114	fumarate hydratase activity
FLK61_RS09345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FLK61_RS09350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FLK61_RS09365	COG0436	Aminotransferase
FLK61_RS09370	COG0567	Dehydrogenase, E1 component
FLK61_RS09375	COG0508	dehydrogenase complex catalyzes the overall conversion of
FLK61_RS09385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FLK61_RS09390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FLK61_RS09410	COG0205	6-phosphofructokinase activity
FLK61_RS09415	COG0671	phosphoesterase, PA-phosphatase related
FLK61_RS09420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FLK61_RS09430	COG1183	phosphatidylcholine synthase activity
FLK61_RS09435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FLK61_RS09440	COG0628	permease
FLK61_RS09445	COG1295	ribonuclease BN
FLK61_RS09450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FLK61_RS09455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FLK61_RS09460	COG0398	Pfam SNARE associated Golgi protein
FLK61_RS09470	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FLK61_RS09475	COG1074	ATP-dependent DNA helicase activity
FLK61_RS09480	COG0420	3'-5' exonuclease activity
FLK61_RS09485	COG0419	ATPase involved in DNA repair
FLK61_RS09495	COG2011	ABC-type metal ion transport system permease component
FLK61_RS09500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FLK61_RS09510	COG1960	acyl-CoA dehydrogenase activity
FLK61_RS09515	COG0488	(ABC) transporter
FLK61_RS09535	COG0523	cobalamin synthesis protein
FLK61_RS09560	COG2267	carboxylic ester hydrolase activity
FLK61_RS09565	COG1764	response to oxidative stress
FLK61_RS09585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FLK61_RS09585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FLK61_RS09590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FLK61_RS09600	COG0346	lactoylglutathione lyase activity
FLK61_RS09605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FLK61_RS09645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FLK61_RS09650	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FLK61_RS09655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FLK61_RS09660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FLK61_RS09665	COG0505	Belongs to the CarA family
FLK61_RS09675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FLK61_RS09680	COG0137	argininosuccinate synthase activity
FLK61_RS09685	COG0165	Argininosuccinate lyase
FLK61_RS09690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FLK61_RS09695	COG3209	COG3209 Rhs family protein
FLK61_RS09740	COG3209	COG3209 Rhs family protein
FLK61_RS09755	COG4637	Psort location Cytoplasmic, score
FLK61_RS09765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FLK61_RS09775	COG3011	Protein conserved in bacteria
FLK61_RS09780	COG0456	acetyltransferase
FLK61_RS09795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FLK61_RS09800	COG0582	viral genome integration into host DNA
FLK61_RS09805	COG3180	Ammonia monooxygenase
FLK61_RS09810	COG1917	Cupin 2, conserved barrel domain protein
FLK61_RS09815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FLK61_RS09820	COG0456	acetyltransferase
FLK61_RS09835	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FLK61_RS09850	COG3830	Belongs to the UPF0237 family
FLK61_RS09860	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
FLK61_RS09870	COG0004	ammonium transporteR
FLK61_RS09890	COG4221	oxidoreductase activity
FLK61_RS09895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FLK61_RS09900	COG2996	Protein conserved in bacteria
FLK61_RS09905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FLK61_RS09905	COG0551	DNA topoisomerase type I activity
FLK61_RS09910	COG1408	metallophosphoesterase
FLK61_RS09930	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS09940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FLK61_RS09950	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FLK61_RS09960	COG0561	phosphatase activity
FLK61_RS09985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FLK61_RS10000	COG0577	efflux transmembrane transporter activity
FLK61_RS10005	COG1136	(ABC) transporter
FLK61_RS10010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FLK61_RS10015	COG0187	DNA topoisomerase II activity
FLK61_RS10020	COG1832	CoA-binding protein
FLK61_RS10030	COG1174	glycine betaine transport
FLK61_RS10040	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FLK61_RS10055	COG0116	Belongs to the methyltransferase superfamily
FLK61_RS10065	COG0328	RNA-DNA hybrid ribonuclease activity
FLK61_RS10070	COG3599	regulation of cell shape
FLK61_RS10095	COG3359	exonuclease
FLK61_RS10100	COG1205	dead DEAH box helicase
FLK61_RS10100	COG1111	helicase
FLK61_RS10105	COG1331	Highly conserved protein containing a thioredoxin domain
FLK61_RS10120	COG2267	carboxylic ester hydrolase activity
FLK61_RS10125	COG0693	protein deglycase activity
FLK61_RS10130	COG1418	mRNA catabolic process
FLK61_RS10140	COG0784	Response regulator, receiver
FLK61_RS10140	COG0835	chemotaxis
FLK61_RS10155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FLK61_RS10195	COG2200	EAL domain
FLK61_RS10200	COG0613	PHP domain protein
FLK61_RS10205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FLK61_RS10215	COG0824	Thioesterase
FLK61_RS10220	COG0464	growth
FLK61_RS10225	COG0398	Pfam SNARE associated Golgi protein
FLK61_RS10235	COG2323	membrane
FLK61_RS10240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FLK61_RS10245	COG1921	L-seryl-tRNASec selenium transferase activity
FLK61_RS10270	COG4846	Membrane protein involved in cytochrome C biogenesis
FLK61_RS10290	COG1937	Protein conserved in bacteria
FLK61_RS10295	COG1132	(ABC) transporter
FLK61_RS10300	COG1132	(ABC) transporter
FLK61_RS10305	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FLK61_RS10310	COG3763	UPF0154 protein
FLK61_RS10320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FLK61_RS10325	COG4224	UPF0291 protein
FLK61_RS10330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FLK61_RS10340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FLK61_RS10350	COG0174	glutamine synthetase
FLK61_RS10355	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FLK61_RS10365	COG0464	growth
FLK61_RS10370	COG1923	regulation of RNA biosynthetic process
FLK61_RS10375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FLK61_RS10380	COG2521	methyltransferase
FLK61_RS10380	COG2136	Putative SAM-dependent methyltransferase
FLK61_RS10385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FLK61_RS10390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FLK61_RS10400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FLK61_RS10405	COG4550	Control of competence regulator ComK, YlbF/YmcA
FLK61_RS10410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FLK61_RS10415	COG0156	8-amino-7-oxononanoate synthase activity
FLK61_RS10420	COG1063	alcohol dehydrogenase
FLK61_RS10425	COG2359	stage V sporulation protein S
FLK61_RS10430	COG1692	metallophosphoesterase
FLK61_RS10435	COG1418	mRNA catabolic process
FLK61_RS10440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FLK61_RS10445	COG0513	Belongs to the DEAD box helicase family
FLK61_RS10450	COG1058	Belongs to the CinA family
FLK61_RS10450	COG1546	Belongs to the CinA family
FLK61_RS10455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FLK61_RS10460	COG1426	Protein conserved in bacteria
FLK61_RS10475	COG0300	oxidoreductase activity
FLK61_RS10480	COG0612	Peptidase, M16
FLK61_RS10485	COG0612	Peptidase, M16
FLK61_RS10490	COG2188	Transcriptional regulator
FLK61_RS10495	COG1674	ftsk spoiiie
FLK61_RS10500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FLK61_RS10510	COG0527	aspartate kinase activity
FLK61_RS10515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FLK61_RS10520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FLK61_RS10525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FLK61_RS10530	COG1873	PFAM PRC-barrel domain
FLK61_RS10535	COG0612	Peptidase, M16
FLK61_RS10540	COG0726	polysaccharide deacetylase
FLK61_RS10545	COG1185	polyribonucleotide nucleotidyltransferase activity
FLK61_RS10550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FLK61_RS10555	COG0196	riboflavin kinase activity
FLK61_RS10560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FLK61_RS10565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FLK61_RS10575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FLK61_RS10580	COG1358	cellular component organization or biogenesis
FLK61_RS10585	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FLK61_RS10590	COG0195	Participates in both transcription termination and antitermination
FLK61_RS10595	COG0779	Required for maturation of 30S ribosomal subunits
FLK61_RS10600	COG2176	DNA-directed DNA polymerase activity
FLK61_RS10605	COG0442	prolyl-tRNA aminoacylation
FLK61_RS10610	COG0750	zinc metalloprotease
FLK61_RS10620	COG4589	Belongs to the CDS family
FLK61_RS10625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FLK61_RS10630	COG0233	cytoplasmic translational termination
FLK61_RS10635	COG0528	UMP kinase activity
FLK61_RS10640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FLK61_RS10645	COG0052	Belongs to the universal ribosomal protein uS2 family
FLK61_RS10665	COG1191	sigma factor activity
FLK61_RS10675	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FLK61_RS10680	COG1776	CheC inhibitor of MCP methylation
FLK61_RS10685	COG0835	chemotaxis
FLK61_RS10690	COG2198	Histidine kinase
FLK61_RS10690	COG0643	Histidine kinase
FLK61_RS10695	COG2201	protein-glutamate methylesterase activity
FLK61_RS10700	COG0455	bacterial-type flagellum organization
FLK61_RS10705	COG1419	protein localization to endoplasmic reticulum
FLK61_RS10710	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FLK61_RS10715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FLK61_RS10720	COG1684	flagellar biosynthetic protein fliR
FLK61_RS10725	COG1987	bacterial-type flagellum assembly
FLK61_RS10730	COG1338	Plays a role in the flagellum-specific transport system
FLK61_RS10735	COG3190	flagellar
FLK61_RS10740	COG2201	protein-glutamate methylesterase activity
FLK61_RS10745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FLK61_RS10745	COG1776	CheC inhibitor of MCP methylation
FLK61_RS10750	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FLK61_RS10755	COG1580	Controls the rotational direction of flagella during chemotaxis
FLK61_RS10760	COG1582	Flagellar protein (FlbD)
FLK61_RS10765	COG4786	Flagellar basal body rod
FLK61_RS10775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FLK61_RS10795	COG1157	protein secretion by the type III secretion system
FLK61_RS10800	COG1317	bacterial-type flagellum organization
FLK61_RS10805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FLK61_RS10810	COG1766	The M ring may be actively involved in energy transduction
FLK61_RS10815	COG1677	Flagellar hook-basal body complex protein FliE
FLK61_RS10820	COG1558	bacterial-type flagellum-dependent cell motility
FLK61_RS10825	COG1815	bacterial-type flagellum-dependent cell motility
FLK61_RS10830	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FLK61_RS10835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FLK61_RS10840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FLK61_RS10845	COG4974	Belongs to the 'phage' integrase family
FLK61_RS10850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FLK61_RS10855	COG0758	DNA mediated transformation
FLK61_RS10860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FLK61_RS10865	COG0045	succinate-CoA ligase (ADP-forming) activity
FLK61_RS10870	COG2257	FlhB HrpN YscU SpaS Family
FLK61_RS10880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FLK61_RS10895	COG0335	large ribosomal subunit rRNA binding
FLK61_RS10900	COG0336	Belongs to the RNA methyltransferase TrmD family
FLK61_RS10905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FLK61_RS10915	COG1837	Belongs to the UPF0109 family
FLK61_RS10920	COG0228	four-way junction DNA binding
FLK61_RS10925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FLK61_RS10935	COG0552	protein localization to endoplasmic reticulum
FLK61_RS10940	COG1196	nuclear chromosome segregation
FLK61_RS10945	COG4840	Belongs to the UPF0435 family
FLK61_RS10955	COG3328	transposase activity
FLK61_RS10965	COG0571	ribonuclease III activity
FLK61_RS10970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FLK61_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS10980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FLK61_RS10985	COG0416	fatty acid biosynthetic process
FLK61_RS10990	COG1349	DNA-binding transcription factor activity
FLK61_RS10995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FLK61_RS11000	COG1760	l-serine dehydratase
FLK61_RS11005	COG1760	l-serine dehydratase
FLK61_RS11010	COG1307	EDD domain protein, DegV family
FLK61_RS11015	COG1461	Dihydroxyacetone kinase
FLK61_RS11020	COG1302	Protein conserved in bacteria
FLK61_RS11025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FLK61_RS11035	COG1564	THIamine pyrophosphokinase
FLK61_RS11040	COG3859	Proton-coupled thiamine transporter YuaJ
FLK61_RS11045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FLK61_RS11050	COG1162	GTPase activity
FLK61_RS11055	COG0515	serine threonine protein kinase
FLK61_RS11055	COG2815	serine threonine protein kinase
FLK61_RS11060	COG0631	protein serine/threonine phosphatase activity
FLK61_RS11065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FLK61_RS11065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FLK61_RS11075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FLK61_RS11080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FLK61_RS11085	COG1758	RNA polymerase activity
FLK61_RS11090	COG0194	GDP metabolic process
FLK61_RS11095	COG2052	Domain of unknown function (DUF370)
FLK61_RS11100	COG1561	YicC-like family, N-terminal region
FLK61_RS11115	COG1132	(ABC) transporter
FLK61_RS11120	COG1132	(ABC) transporter
FLK61_RS11130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FLK61_RS11135	COG0284	orotidine-5'-phosphate decarboxylase activity
FLK61_RS11140	COG0167	dihydroorotate dehydrogenase activity
FLK61_RS11150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FLK61_RS11155	COG0505	Belongs to the CarA family
FLK61_RS11165	COG0540	Belongs to the ATCase OTCase family
FLK61_RS11175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FLK61_RS11180	COG0564	pseudouridine synthase activity
FLK61_RS11185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FLK61_RS11190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FLK61_RS11195	COG3599	regulation of cell shape
FLK61_RS11200	COG2302	S4 RNA-binding domain
FLK61_RS11205	COG0762	integral membrane protein
FLK61_RS11210	COG1799	cell septum assembly
FLK61_RS11215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FLK61_RS11220	COG1873	PFAM PRC-barrel domain
FLK61_RS11225	COG1191	sigma factor activity
FLK61_RS11230	COG1191	sigma factor activity
FLK61_RS11245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FLK61_RS11250	COG0849	cell division
FLK61_RS11255	COG3856	small basic protein
FLK61_RS11260	COG3879	Bacterial protein of unknown function (DUF881)
FLK61_RS11265	COG3879	Bacterial protein of unknown function (DUF881)
FLK61_RS11270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FLK61_RS11280	COG0772	Belongs to the SEDS family
FLK61_RS11285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FLK61_RS11290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FLK61_RS11300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FLK61_RS11305	COG0768	penicillin binding
FLK61_RS11320	COG0275	rRNA processing
FLK61_RS11325	COG2001	Belongs to the MraZ family
FLK61_RS11330	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FLK61_RS11340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FLK61_RS11345	COG0454	-acetyltransferase
FLK61_RS11350	COG1024	Enoyl-CoA hydratase
FLK61_RS11355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FLK61_RS11360	COG1399	metal-binding, possibly nucleic acid-binding protein
FLK61_RS11365	COG1323	Belongs to the UPF0348 family
FLK61_RS11370	COG3480	Lon protease (S16) C-terminal proteolytic domain
FLK61_RS11375	COG3314	Sporulation integral membrane protein YlbJ
FLK61_RS11380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FLK61_RS11385	COG0742	ribosomal rna small subunit methyltransferase
FLK61_RS11390	COG4471	UPF0298 protein
FLK61_RS11395	COG3679	Belongs to the UPF0342 family
FLK61_RS11410	COG2340	Cysteine-rich secretory protein family
FLK61_RS11415	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
FLK61_RS11445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FLK61_RS11460	COG1612	heme a metabolic process
FLK61_RS11465	COG0783	Belongs to the Dps family
FLK61_RS11470	COG4838	Belongs to the UPF0358 family
FLK61_RS11475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FLK61_RS11480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FLK61_RS11490	COG4896	Protein conserved in bacteria
FLK61_RS11505	COG0483	inositol monophosphate 1-phosphatase activity
FLK61_RS11515	COG4493	Belongs to the UPF0637 family
FLK61_RS11520	COG4476	Belongs to the UPF0223 family
FLK61_RS11525	COG1982	Orn Lys Arg decarboxylase major
FLK61_RS11545	COG0726	polysaccharide deacetylase
FLK61_RS11560	COG0508	dehydrogenase complex catalyzes the overall conversion of
FLK61_RS11565	COG0022	dehydrogenase e1 component
FLK61_RS11595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FLK61_RS11600	COG0569	domain protein
FLK61_RS11605	COG0668	transmembrane transport
FLK61_RS11615	COG1473	amidohydrolase
FLK61_RS11620	COG2171	N-acyltransferase activity
FLK61_RS11630	COG0668	transmembrane transport
FLK61_RS11635	COG1132	(ABC) transporter
FLK61_RS11650	COG0778	Nitroreductase
FLK61_RS11665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FLK61_RS11695	COG1278	Cold shock
FLK61_RS11700	COG4989	oxidoreductase activity
FLK61_RS11710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FLK61_RS11735	COG0604	alcohol dehydrogenase
FLK61_RS11740	COG2839	Protein conserved in bacteria
FLK61_RS11755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FLK61_RS11760	COG0747	negative chemotaxis
FLK61_RS11775	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FLK61_RS11785	COG0602	queuosine metabolic process
FLK61_RS11790	COG0720	synthase
FLK61_RS11795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FLK61_RS11810	COG0425	Belongs to the sulfur carrier protein TusA family
FLK61_RS11815	COG0425	Belongs to the sulfur carrier protein TusA family
FLK61_RS11815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FLK61_RS11820	COG2210	Belongs to the sulfur carrier protein TusA family
FLK61_RS11825	COG1937	Protein conserved in bacteria
FLK61_RS11845	COG2962	Rard protein
FLK61_RS11870	COG1131	(ABC) transporter
FLK61_RS11875	COG2188	Transcriptional regulator
FLK61_RS11890	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FLK61_RS11925	COG1053	succinate dehydrogenase
FLK61_RS11925	COG3976	FMN-binding domain protein
FLK61_RS11925	COG0431	NADPH-dependent FMN reductase
FLK61_RS12180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FLK61_RS12235	COG4974	Belongs to the 'phage' integrase family
FLK61_RS12475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FLK61_RS12530	COG4974	Belongs to the 'phage' integrase family
FLK61_RS12535	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FLK61_RS12540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FLK61_RS12545	COG0564	pseudouridine synthase activity
FLK61_RS12550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FLK61_RS12555	COG2357	RelA SpoT domain protein
FLK61_RS12560	COG4116	CYTH
FLK61_RS12565	COG0741	lytic transglycosylase activity
FLK61_RS12570	COG2346	COG2346, Truncated hemoglobins
FLK61_RS12580	COG1164	Oligoendopeptidase f
FLK61_RS12595	COG0861	Integral membrane protein TerC family
FLK61_RS12600	COG1393	Belongs to the ArsC family
FLK61_RS12605	COG0456	acetyltransferase
FLK61_RS12615	COG1418	mRNA catabolic process
FLK61_RS12630	COG1522	sequence-specific DNA binding
FLK61_RS12635	COG1301	dicarboxylic acid transport
FLK61_RS12640	COG0180	Tryptophanyl-tRNA synthetase
FLK61_RS12655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FLK61_RS12660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FLK61_RS12675	COG1744	ABC transporter substrate-binding protein PnrA-like
FLK61_RS12685	COG4841	protein insertion into membrane
FLK61_RS12690	COG1999	signal sequence binding
FLK61_RS12695	COG3336	cytochrome c oxidase
FLK61_RS12710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FLK61_RS12725	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FLK61_RS12730	COG1461	Dihydroxyacetone kinase
FLK61_RS12735	COG2376	Dihydroxyacetone kinase
FLK61_RS12755	COG0747	negative chemotaxis
FLK61_RS12760	COG1609	Transcriptional regulator
FLK61_RS12765	COG3833	ABC-type maltose transport systems, permease component
FLK61_RS12770	COG1175	transmembrane transport
FLK61_RS12775	COG2182	Extracellular solute-binding protein
FLK61_RS12780	COG0840	transmembrane signaling receptor activity
FLK61_RS12785	COG2207	Transcriptional regulator
FLK61_RS12785	COG1917	Cupin 2, conserved barrel domain protein
FLK61_RS12790	COG0534	Mate efflux family protein
FLK61_RS12795	COG2358	TRAP transporter, solute receptor (TAXI family
FLK61_RS12810	COG1509	lysine 2,3-aminomutase activity
FLK61_RS12825	COG2249	NAD(P)H dehydrogenase (quinone) activity
FLK61_RS12830	COG5001	Diguanylate cyclase
FLK61_RS12830	COG3706	GGDEF domain
FLK61_RS12830	COG4251	negative regulation of phosphorylation
FLK61_RS12830	COG2203	Gaf domain
FLK61_RS12835	COG2154	pterin-4-alpha-carbinolamine dehydratase
FLK61_RS12845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FLK61_RS12850	COG0640	Transcriptional regulator
FLK61_RS12885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FLK61_RS12910	COG0686	Belongs to the AlaDH PNT family
FLK61_RS12920	COG2801	Transposase and inactivated derivatives
FLK61_RS12935	COG0745	RESPONSE REGULATOR receiver
FLK61_RS12940	COG0704	Plays a role in the regulation of phosphate uptake
FLK61_RS12945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FLK61_RS12950	COG0581	inorganic phosphate transmembrane transporter activity
FLK61_RS12955	COG0573	inorganic phosphate transmembrane transporter activity
FLK61_RS12960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FLK61_RS12970	COG1234	tRNA 3'-trailer cleavage
FLK61_RS12975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FLK61_RS12980	COG2868	ribosomal protein
FLK61_RS12985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FLK61_RS12990	COG1530	ribonuclease E activity
FLK61_RS13015	COG1609	Transcriptional regulator
FLK61_RS13020	COG1653	transport
FLK61_RS13025	COG2894	cell division
FLK61_RS13030	COG0850	regulation of cytokinetic process
FLK61_RS13035	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FLK61_RS13040	COG1792	Involved in formation and maintenance of cell shape
FLK61_RS13045	COG1077	Cell shape determining protein MreB Mrl
FLK61_RS13050	COG2003	Belongs to the UPF0758 family
FLK61_RS13060	COG2003	Belongs to the UPF0758 family
FLK61_RS13065	COG0424	maF-like protein
FLK61_RS13090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FLK61_RS13100	COG1459	type II secretion system
FLK61_RS13110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FLK61_RS13125	COG0285	dihydrofolate synthase activity
FLK61_RS13135	COG0189	ligase activity
FLK61_RS13140	COG2197	response regulator
FLK61_RS13165	COG2252	PERMEase
FLK61_RS13170	COG0525	valine-tRNA ligase activity
FLK61_RS13180	COG1388	LysM domain
FLK61_RS13205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FLK61_RS13210	COG0113	porphobilinogen synthase activity
FLK61_RS13220	COG0181	hydroxymethylbilane synthase activity
FLK61_RS13225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FLK61_RS13230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FLK61_RS13235	COG1126	abc transporter atp-binding protein
FLK61_RS13240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FLK61_RS13245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FLK61_RS13250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FLK61_RS13255	COG0544	peptidyl-prolyl cis-trans isomerase activity
FLK61_RS13260	COG0457	Tetratricopeptide repeat
FLK61_RS13260	COG1477	protein flavinylation
FLK61_RS13280	COG4824	toxin secretion phage lysis holin
FLK61_RS13425	COG0582	viral genome integration into host DNA
FLK61_RS13485	COG0305	Participates in initiation and elongation during chromosome replication
FLK61_RS13535	COG1396	sequence-specific DNA binding
FLK61_RS13555	COG4974	Belongs to the 'phage' integrase family
FLK61_RS13675	COG0622	Phosphoesterase
FLK61_RS13680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FLK61_RS13685	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FLK61_RS13690	COG5401	PFAM Sporulation and spore germination
FLK61_RS13710	COG1846	Transcriptional regulator
FLK61_RS13720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FLK61_RS13725	COG3711	transcriptional antiterminator
FLK61_RS13730	COG2197	response regulator
FLK61_RS13740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FLK61_RS13745	COG1053	succinate dehydrogenase
FLK61_RS13750	COG2009	succinate dehydrogenase
FLK61_RS13755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FLK61_RS13775	COG0322	excinuclease ABC activity
FLK61_RS13780	COG3118	belongs to the thioredoxin family
FLK61_RS13785	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FLK61_RS13790	COG2086	electron transfer activity
FLK61_RS13795	COG1024	Enoyl-CoA hydratase
FLK61_RS13800	COG1309	transcriptional regulator
FLK61_RS13805	COG0318	PFAM AMP-dependent synthetase and ligase
FLK61_RS13810	COG0318	PFAM AMP-dependent synthetase and ligase
FLK61_RS13835	COG3766	membrane
FLK61_RS13840	COG1193	negative regulation of DNA recombination
FLK61_RS13845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FLK61_RS13845	COG1796	DNA polymerase
FLK61_RS13850	COG1286	toxin biosynthetic process
FLK61_RS13855	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FLK61_RS13860	COG0135	phosphoribosylanthranilate isomerase activity
FLK61_RS13865	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FLK61_RS13875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FLK61_RS13875	COG0072	phenylalanine-tRNA ligase activity
FLK61_RS13880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FLK61_RS13885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FLK61_RS13895	COG1363	Peptidase, m42
FLK61_RS13900	COG0756	dUTP diphosphatase activity
FLK61_RS13920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FLK61_RS13925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FLK61_RS13930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FLK61_RS13940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FLK61_RS13950	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FLK61_RS13955	COG1484	DNA-dependent DNA replication
FLK61_RS13960	COG3611	Membrane attachment protein
FLK61_RS13965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FLK61_RS13975	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FLK61_RS13980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FLK61_RS13990	COG1971	Probably functions as a manganese efflux pump
FLK61_RS13995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FLK61_RS14000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FLK61_RS14000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FLK61_RS14005	COG5002	protein histidine kinase activity
FLK61_RS14010	COG0745	RESPONSE REGULATOR receiver
FLK61_RS14020	COG0039	L-malate dehydrogenase activity
FLK61_RS14025	COG0538	isocitrate dehydrogenase activity
FLK61_RS14030	COG0372	Belongs to the citrate synthase family
FLK61_RS14035	COG2707	UPF0756 membrane protein
FLK61_RS14040	COG3030	protein affecting phage T7 exclusion by the F plasmid
FLK61_RS14050	COG0205	6-phosphofructokinase activity
FLK61_RS14055	COG0825	malonyl-CoA metabolic process
FLK61_RS14060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FLK61_RS14065	COG2186	Transcriptional regulator
FLK61_RS14070	COG0281	malic enzyme
FLK61_RS14075	COG0587	DNA-directed DNA polymerase activity
FLK61_RS14090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FLK61_RS14100	COG4109	DRTGG domain
FLK61_RS14110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FLK61_RS14115	COG0006	proline dipeptidase activity
FLK61_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS14145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FLK61_RS14150	COG0827	DNA restriction-modification system
FLK61_RS14160	COG3874	Sporulation protein YtfJ
FLK61_RS14170	COG1714	RDD family
FLK61_RS14175	COG0616	signal peptide processing
FLK61_RS14180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FLK61_RS14185	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FLK61_RS14195	COG1104	cysteine desulfurase activity
FLK61_RS14205	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FLK61_RS14210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FLK61_RS14215	COG1309	transcriptional regulator
FLK61_RS14220	COG1956	GAF domain-containing protein
FLK61_RS14225	COG2203	Gaf domain
FLK61_RS14225	COG2199	diguanylate cyclase activity
FLK61_RS14230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FLK61_RS14250	COG0454	-acetyltransferase
FLK61_RS14255	COG0516	GMP reductase activity
FLK61_RS14255	COG0517	IMP dehydrogenase activity
FLK61_RS14260	COG0123	including yeast histone deacetylase and acetoin utilization protein
FLK61_RS14265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FLK61_RS14285	COG1605	Chorismate mutase
FLK61_RS14285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FLK61_RS14290	COG0849	cell division
FLK61_RS14295	COG3118	belongs to the thioredoxin family
FLK61_RS14300	COG4980	gas vesicle protein
FLK61_RS14315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FLK61_RS14335	COG1674	ftsk spoiiie
FLK61_RS14340	COG4848	Belongs to the UPF0354 family
FLK61_RS14345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FLK61_RS14365	COG1363	Peptidase, m42
FLK61_RS14375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FLK61_RS14380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FLK61_RS14385	COG0510	thiamine kinase activity
FLK61_RS14390	COG1523	belongs to the glycosyl hydrolase 13 family
FLK61_RS14395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FLK61_RS14400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FLK61_RS14405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FLK61_RS14410	COG0297	glycogen (starch) synthase activity
FLK61_RS14415	COG0058	SHG alpha-glucan phosphorylase activity
FLK61_RS14430	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FLK61_RS14435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FLK61_RS14445	COG1349	DNA-binding transcription factor activity
FLK61_RS14450	COG1187	pseudouridine synthase activity
FLK61_RS14455	COG0772	Belongs to the SEDS family
FLK61_RS14470	COG1733	regulation of RNA biosynthetic process
FLK61_RS14475	COG2244	polysaccharide biosynthetic process
FLK61_RS14480	COG0432	Pfam Uncharacterised protein family UPF0047
FLK61_RS14485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FLK61_RS14495	COG2081	HI0933 family
FLK61_RS14500	COG0495	leucyl-tRNA aminoacylation
FLK61_RS14505	COG2814	Major facilitator Superfamily
FLK61_RS14515	COG1242	4 iron, 4 sulfur cluster binding
FLK61_RS14520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FLK61_RS14525	COG2267	carboxylic ester hydrolase activity
FLK61_RS14530	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FLK61_RS14535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FLK61_RS14540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FLK61_RS14545	COG1116	anion transmembrane transporter activity
FLK61_RS14550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FLK61_RS14555	COG0494	nUDIX hydrolase
FLK61_RS14560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FLK61_RS14570	COG0840	transmembrane signaling receptor activity
FLK61_RS14570	COG5278	phosphoserine phosphatase activity
FLK61_RS14585	COG1011	Hydrolase
FLK61_RS14590	COG2133	pyrroloquinoline quinone binding
FLK61_RS14600	COG2184	nucleotidyltransferase activity
FLK61_RS14620	COG3186	Phenylalanine-4-hydroxylase
FLK61_RS14630	COG1012	belongs to the aldehyde dehydrogenase family
FLK61_RS14645	COG0006	proline dipeptidase activity
FLK61_RS14650	COG0402	S-adenosylhomocysteine deaminase activity
FLK61_RS14655	COG2508	Transcriptional regulator
FLK61_RS14660	COG0733	neurotransmitter:sodium symporter activity
FLK61_RS14665	COG0179	Fumarylacetoacetate (FAA) hydrolase
FLK61_RS14680	COG0671	phosphoesterase, PA-phosphatase related
FLK61_RS14715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FLK61_RS14725	COG0166	Belongs to the GPI family
FLK61_RS14730	COG1979	alcohol dehydrogenase
FLK61_RS14735	COG2155	Conserved Protein
FLK61_RS14740	COG1098	S1 RNA binding domain
FLK61_RS14745	COG0436	Aminotransferase
FLK61_RS14750	COG1522	sequence-specific DNA binding
FLK61_RS14760	COG1012	belongs to the aldehyde dehydrogenase family
FLK61_RS14860	COG2056	Na+-H+ antiporter family
FLK61_RS14865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FLK61_RS14870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FLK61_RS14880	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
FLK61_RS14895	COG1252	NADH dehydrogenase
FLK61_RS14910	COG0316	Belongs to the HesB IscA family
FLK61_RS14915	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FLK61_RS14925	COG4844	belongs to the
FLK61_RS14930	COG1252	NADH dehydrogenase
FLK61_RS14935	COG4837	Protein of unknown function (DUF1462)
FLK61_RS14940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FLK61_RS14945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FLK61_RS14955	COG0647	UMP catabolic process
FLK61_RS14960	COG2445	Protein of unknown function DUF86
FLK61_RS14965	COG1494	fructose-1,6-bisphosphatase
FLK61_RS14975	COG4470	Protein conserved in bacteria
FLK61_RS14985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FLK61_RS14990	COG0739	heme binding
FLK61_RS14995	COG0733	neurotransmitter:sodium symporter activity
FLK61_RS15000	COG1757	Na H antiporter
FLK61_RS15010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FLK61_RS15025	COG0737	Belongs to the 5'-nucleotidase family
FLK61_RS15030	COG0730	response to heat
FLK61_RS15035	COG1801	Protein of unknown function DUF72
FLK61_RS15040	COG3546	catalase activity
FLK61_RS15055	COG0719	Fe-S assembly protein
FLK61_RS15060	COG0822	iron-sulfur transferase activity
FLK61_RS15065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FLK61_RS15070	COG0719	Fe-S assembly protein
FLK61_RS15075	COG0396	ATPase activity
FLK61_RS15080	COG1464	Belongs to the NlpA lipoprotein family
FLK61_RS15085	COG2011	ABC-type metal ion transport system permease component
FLK61_RS15090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FLK61_RS15100	COG0509	glycine decarboxylation via glycine cleavage system
FLK61_RS15105	COG1393	Belongs to the ArsC family
FLK61_RS15115	COG1960	acyl-CoA dehydrogenase activity
FLK61_RS15120	COG0183	Belongs to the thiolase family
FLK61_RS15125	COG1250	3-hydroxyacyl-CoA dehydrogenase
FLK61_RS15125	COG1024	Enoyl-CoA hydratase
FLK61_RS15135	COG5577	PFAM Coat F domain
FLK61_RS15140	COG0201	protein transport
FLK61_RS15155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FLK61_RS15165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FLK61_RS15180	COG0129	dihydroxy-acid dehydratase activity
FLK61_RS15190	COG2116	formate transmembrane transporter activity
FLK61_RS15210	COG0557	exoribonuclease II activity
FLK61_RS15215	COG1647	Serine aminopeptidase, S33
FLK61_RS15225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FLK61_RS15230	COG0673	inositol 2-dehydrogenase activity
FLK61_RS15240	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FLK61_RS15245	COG0148	phosphopyruvate hydratase activity
FLK61_RS15250	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FLK61_RS15265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FLK61_RS15280	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FLK61_RS15285	COG0740	serine-type endopeptidase activity
FLK61_RS15290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FLK61_RS15295	COG1481	regulation of sporulation
FLK61_RS15300	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FLK61_RS15305	COG1660	Displays ATPase and GTPase activities
FLK61_RS15310	COG1051	belongs to the nudix hydrolase family
FLK61_RS15315	COG0492	ferredoxin-NADP+ reductase activity
FLK61_RS15340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FLK61_RS15340	COG0140	phosphoribosyl-ATP diphosphatase activity
FLK61_RS15345	COG0107	imidazoleglycerol-phosphate synthase activity
FLK61_RS15350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FLK61_RS15355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FLK61_RS15360	COG0131	Imidazoleglycerol-phosphate dehydratase
FLK61_RS15365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FLK61_RS15370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FLK61_RS15375	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FLK61_RS15380	COG0110	maltose O-acetyltransferase activity
FLK61_RS15385	COG0546	phosphoglycolate phosphatase activity
FLK61_RS15390	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FLK61_RS15395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FLK61_RS15400	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FLK61_RS15405	COG1950	PFAM Membrane protein of
FLK61_RS15410	COG1983	PspC domain protein
FLK61_RS15415	COG3595	metallopeptidase activity
FLK61_RS15420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FLK61_RS15425	COG0556	nucleotide-excision repair
FLK61_RS15430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FLK61_RS15435	COG0793	Belongs to the peptidase S41A family
FLK61_RS15435	COG3409	Peptidoglycan-binding domain 1 protein
FLK61_RS15440	COG0741	lytic transglycosylase activity
FLK61_RS15440	COG1196	nuclear chromosome segregation
FLK61_RS15440	COG0739	heme binding
FLK61_RS15445	COG2177	Part of the ABC transporter FtsEX involved in
FLK61_RS15450	COG2884	Cell division ATP-binding protein ftsE
FLK61_RS15460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FLK61_RS15470	COG0653	protein targeting
FLK61_RS15485	COG3711	transcriptional antiterminator
FLK61_RS15490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FLK61_RS15490	COG2190	(PTS) system
FLK61_RS15490	COG1263	PTS System
FLK61_RS15510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FLK61_RS15515	COG1278	Cold shock
FLK61_RS15520	COG0629	single-stranded DNA binding
FLK61_RS15530	COG1482	cell wall glycoprotein biosynthetic process
FLK61_RS15570	COG3458	cephalosporin-C deacetylase activity
FLK61_RS15585	COG1334	flagellar protein FlaG
FLK61_RS15595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FLK61_RS15605	COG1309	transcriptional regulator
FLK61_RS15610	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FLK61_RS15645	COG3239	Fatty acid desaturase
FLK61_RS15705	COG3063	Type IV pilus biogenesis stability protein PilW
FLK61_RS15725	COG0456	acetyltransferase
FLK61_RS15725	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FLK61_RS15735	COG4585	Histidine kinase
FLK61_RS15740	COG2197	response regulator
FLK61_RS15745	COG2843	Capsule synthesis protein
FLK61_RS15750	COG0778	Nitroreductase
FLK61_RS15760	COG0167	dihydroorotate dehydrogenase activity
FLK61_RS15765	COG0543	2 iron, 2 sulfur cluster binding
FLK61_RS15770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FLK61_RS15775	COG2508	Transcriptional regulator
FLK61_RS15785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FLK61_RS15795	COG0737	Belongs to the 5'-nucleotidase family
FLK61_RS15810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FLK61_RS15825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FLK61_RS15850	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FLK61_RS15855	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FLK61_RS15865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FLK61_RS15870	COG4786	Flagellar basal body rod
FLK61_RS15870	COG1256	bacterial-type flagellum assembly
FLK61_RS15880	COG2747	anti-sigma28 factor FlgM
FLK61_RS15890	COG1040	competence protein
FLK61_RS15895	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FLK61_RS15900	COG1307	EDD domain protein, DegV family
FLK61_RS15920	COG1739	Uncharacterized protein family UPF0029
FLK61_RS15930	COG2801	Transposase and inactivated derivatives
FLK61_RS15940	COG0395	ABC-type sugar transport system, permease component
FLK61_RS15950	COG1653	transport
FLK61_RS15955	COG5578	integral membrane protein
FLK61_RS15965	COG2723	6-phospho-beta-galactosidase activity
FLK61_RS15970	COG1940	carbohydrate kinase activity
FLK61_RS15980	COG3620	sequence-specific DNA binding
FLK61_RS15985	COG1316	TRANSCRIPTIONal
FLK61_RS15990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FLK61_RS16005	COG2244	polysaccharide biosynthetic process
FLK61_RS16015	COG0653	protein targeting
FLK61_RS16025	COG0860	N-Acetylmuramoyl-L-alanine amidase
FLK61_RS16030	COG4193	domain, Protein
FLK61_RS16030	COG5263	repeat protein
FLK61_RS16075	COG2340	Cysteine-rich secretory protein family
FLK61_RS16085	COG5001	Diguanylate cyclase
FLK61_RS16090	COG2911	Protein conserved in bacteria
FLK61_RS16090	COG1361	Conserved repeat domain
FLK61_RS16090	COG3266	domain, Protein
FLK61_RS16100	COG0737	Belongs to the 5'-nucleotidase family
FLK61_RS16105	COG0737	Belongs to the 5'-nucleotidase family
FLK61_RS16115	COG1686	Belongs to the peptidase S11 family
FLK61_RS16125	COG2268	Band 7 protein
FLK61_RS16140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FLK61_RS16165	COG1653	transport
FLK61_RS16175	COG1285	pathogenesis
FLK61_RS16180	COG2151	metal-sulfur cluster biosynthetic enzyme
FLK61_RS16185	COG0840	transmembrane signaling receptor activity
FLK61_RS16185	COG3290	protein histidine kinase activity
FLK61_RS16190	COG3361	conserved protein (COG2071)
FLK61_RS16195	COG0415	Belongs to the DNA photolyase family
FLK61_RS16200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FLK61_RS16210	COG2311	Membrane
FLK61_RS16220	COG1984	allophanate hydrolase subunit 2
FLK61_RS16230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FLK61_RS16235	COG4191	Histidine kinase
FLK61_RS16240	COG1744	ABC transporter substrate-binding protein PnrA-like
FLK61_RS16245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FLK61_RS16260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FLK61_RS16290	COG0326	Molecular chaperone. Has ATPase activity
FLK61_RS16295	COG3328	transposase activity
FLK61_RS16315	COG2197	response regulator
FLK61_RS16340	COG1309	transcriptional regulator
FLK61_RS16345	COG1131	(ABC) transporter
FLK61_RS16350	COG3559	Exporter of polyketide antibiotics
FLK61_RS16375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FLK61_RS16385	COG0022	dehydrogenase e1 component
FLK61_RS16385	COG0508	dehydrogenase complex catalyzes the overall conversion of
FLK61_RS16390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FLK61_RS16400	COG3730	PTS system glucitol sorbitol-specific
FLK61_RS16405	COG3732	PTS system glucitol sorbitol-specific
FLK61_RS16430	COG3443	Belongs to the bacterial solute-binding protein 9 family
FLK61_RS16435	COG0697	spore germination
FLK61_RS16445	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FLK61_RS16450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FLK61_RS16455	COG0574	Belongs to the PEP-utilizing enzyme family
FLK61_RS16455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FLK61_RS16460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FLK61_RS16470	COG2304	oxidoreductase activity
FLK61_RS16505	COG2304	oxidoreductase activity
FLK61_RS16570	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FLK61_RS16580	COG3639	organic phosphonate transmembrane transporter activity
FLK61_RS16585	COG0561	phosphatase activity
FLK61_RS16595	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FLK61_RS16605	COG0800	Aldolase
FLK61_RS16610	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS16615	COG1312	Catalyzes the dehydration of D-mannonate
FLK61_RS16620	COG1904	glucuronate isomerase
FLK61_RS16625	COG3250	beta-galactosidase activity
FLK61_RS16630	COG2207	Transcriptional regulator
FLK61_RS16630	COG4753	response regulator
FLK61_RS16635	COG2972	Histidine kinase
FLK61_RS16640	COG1653	transport
FLK61_RS16645	COG0395	ABC-type sugar transport system, permease component
FLK61_RS16650	COG1175	transmembrane transport
FLK61_RS16665	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FLK61_RS16670	COG3173	Aminoglycoside phosphotransferase
FLK61_RS16675	COG0840	transmembrane signaling receptor activity
FLK61_RS16690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FLK61_RS16695	COG1528	Iron-storage protein
FLK61_RS16700	COG3250	beta-galactosidase activity
FLK61_RS16720	COG3275	phosphorelay sensor kinase activity
FLK61_RS16725	COG4753	response regulator
FLK61_RS16725	COG2207	Transcriptional regulator
FLK61_RS16730	COG3290	protein histidine kinase activity
FLK61_RS16730	COG0840	transmembrane signaling receptor activity
FLK61_RS16740	COG0281	malic enzyme
FLK61_RS16745	COG4565	transcriptional regulatory protein
FLK61_RS16750	COG3290	protein histidine kinase activity
FLK61_RS16760	COG3177	Filamentation induced by cAMP protein fic
FLK61_RS16765	COG2318	DinB family
FLK61_RS16790	COG1486	melibiose metabolic process
FLK61_RS16795	COG2188	Transcriptional regulator
FLK61_RS16855	COG2182	Extracellular solute-binding protein
FLK61_RS16870	COG1879	ABC-type sugar transport system periplasmic component
FLK61_RS16875	COG1172	Belongs to the binding-protein-dependent transport system permease family
FLK61_RS16880	COG1129	ABC transporter
FLK61_RS16885	COG1869	D-ribose catabolic process
FLK61_RS16890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FLK61_RS16895	COG1609	Transcriptional regulator
FLK61_RS16900	COG0658	competence protein
FLK61_RS16900	COG2333	competence protein COMEC
FLK61_RS16910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FLK61_RS16915	COG1846	Transcriptional regulator
FLK61_RS16935	COG4753	response regulator
FLK61_RS16935	COG2207	Transcriptional regulator
FLK61_RS16950	COG3842	ATPase activity
FLK61_RS16985	COG2213	PTS system mannitol-specific
FLK61_RS16995	COG0246	Mannitol dehydrogenase
FLK61_RS17000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FLK61_RS17005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FLK61_RS17015	COG3328	transposase activity
FLK61_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS17035	COG0277	FAD linked oxidase domain protein
FLK61_RS17040	COG1070	Carbohydrate kinase
FLK61_RS17075	COG0657	acetylesterase activity
FLK61_RS17090	COG2801	Transposase and inactivated derivatives
FLK61_RS17125	COG0655	NAD(P)H dehydrogenase (quinone) activity
FLK61_RS17130	COG0583	DNA-binding transcription factor activity
FLK61_RS17160	COG3206	protein involved in exopolysaccharide biosynthesis
FLK61_RS17170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FLK61_RS17195	COG0438	transferase activity, transferring glycosyl groups
FLK61_RS17200	COG0438	transferase activity, transferring glycosyl groups
FLK61_RS17205	COG1045	serine acetyltransferase
FLK61_RS17210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FLK61_RS17215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FLK61_RS17220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FLK61_RS17230	COG4464	protein tyrosine phosphatase activity
FLK61_RS17235	COG0489	protein tyrosine kinase activity
FLK61_RS17240	COG3944	biosynthesis protein
FLK61_RS17255	COG3693	PFAM glycoside hydrolase, family 10
FLK61_RS17305	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FLK61_RS17330	COG3328	transposase activity
FLK61_RS17340	COG1523	belongs to the glycosyl hydrolase 13 family
FLK61_RS17350	COG3266	domain, Protein
FLK61_RS17350	COG1361	Conserved repeat domain
FLK61_RS17350	COG2911	Protein conserved in bacteria
FLK61_RS17395	COG1472	Belongs to the glycosyl hydrolase 3 family
FLK61_RS17400	COG0662	Cupin 2, conserved barrel domain protein
FLK61_RS17400	COG2207	Transcriptional regulator
FLK61_RS17405	COG1361	Conserved repeat domain
FLK61_RS17405	COG2911	Protein conserved in bacteria
FLK61_RS17405	COG3266	domain, Protein
FLK61_RS17415	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS17425	COG2911	Protein conserved in bacteria
FLK61_RS17425	COG1361	Conserved repeat domain
FLK61_RS17425	COG3266	domain, Protein
FLK61_RS17430	COG1523	belongs to the glycosyl hydrolase 13 family
FLK61_RS17440	COG0569	domain protein
FLK61_RS17445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FLK61_RS17460	COG3275	phosphorelay sensor kinase activity
FLK61_RS17470	COG1966	Carbon starvation protein
FLK61_RS17475	COG3654	unkown
FLK61_RS17490	COG0745	RESPONSE REGULATOR receiver
FLK61_RS17495	COG5002	protein histidine kinase activity
FLK61_RS17530	COG0561	phosphatase activity
FLK61_RS17545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FLK61_RS17580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FLK61_RS17585	COG1361	Conserved repeat domain
FLK61_RS17595	COG5294	Protein conserved in bacteria
FLK61_RS17600	COG0577	efflux transmembrane transporter activity
FLK61_RS17605	COG1136	(ABC) transporter
FLK61_RS17610	COG2205	protein histidine kinase activity
FLK61_RS17615	COG0745	RESPONSE REGULATOR receiver
FLK61_RS17620	COG0778	Nitroreductase
FLK61_RS17650	COG0791	NLP P60 protein
FLK61_RS17650	COG1388	LysM domain
FLK61_RS17665	COG0840	transmembrane signaling receptor activity
FLK61_RS17675	COG1404	Belongs to the peptidase S8 family
FLK61_RS17680	COG0456	acetyltransferase
FLK61_RS17700	COG1595	DNA-templated transcription, initiation
FLK61_RS17715	COG0860	N-Acetylmuramoyl-L-alanine amidase
FLK61_RS17715	COG2247	cell wall binding repeat
FLK61_RS17720	COG0577	efflux transmembrane transporter activity
FLK61_RS17720	COG1136	(ABC) transporter
FLK61_RS17735	COG0789	Transcriptional regulator
FLK61_RS17740	COG1309	transcriptional regulator
FLK61_RS17745	COG2814	Major facilitator Superfamily
FLK61_RS17755	COG1595	DNA-templated transcription, initiation
FLK61_RS17780	COG0737	Belongs to the 5'-nucleotidase family
FLK61_RS17785	COG0840	transmembrane signaling receptor activity
FLK61_RS17790	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FLK61_RS17795	COG1737	Transcriptional regulator
FLK61_RS17800	COG1070	Carbohydrate kinase
FLK61_RS17805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FLK61_RS17810	COG0129	dihydroxy-acid dehydratase activity
FLK61_RS17815	COG1414	Transcriptional regulator
FLK61_RS17830	COG0300	oxidoreductase activity
FLK61_RS17840	COG1388	LysM domain
FLK61_RS17840	COG0791	NLP P60 protein
FLK61_RS17875	COG4786	Flagellar basal body rod
FLK61_RS17880	COG4786	Flagellar basal body rod
FLK61_RS17890	COG1609	Transcriptional regulator
FLK61_RS17895	COG0739	heme binding
FLK61_RS17900	COG2385	sporulation resulting in formation of a cellular spore
FLK61_RS17905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FLK61_RS17915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FLK61_RS17920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FLK61_RS17950	COG0356	it plays a direct role in the translocation of protons across the membrane
FLK61_RS17965	COG1404	Belongs to the peptidase S8 family
FLK61_RS17975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FLK61_RS17980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FLK61_RS17985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FLK61_RS17990	COG4475	Protein of unknown function (DUF436)
FLK61_RS17995	COG0698	ribose 5-phosphate isomerase
FLK61_RS18005	COG1971	Probably functions as a manganese efflux pump
FLK61_RS18030	COG0009	L-threonylcarbamoyladenylate synthase
FLK61_RS18045	COG2890	protein-(glutamine-N5) methyltransferase activity
FLK61_RS18050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FLK61_RS18060	COG2801	Transposase and inactivated derivatives
FLK61_RS18085	COG1435	thymidine kinase activity
FLK61_RS18090	COG0254	rRNA binding
FLK61_RS18095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FLK61_RS18100	COG1494	fructose-1,6-bisphosphatase
FLK61_RS18105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FLK61_RS18110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FLK61_RS18115	COG0191	fructose-bisphosphate aldolase activity
FLK61_RS18120	COG2204	response regulator
FLK61_RS18145	COG0504	CTP synthase activity
FLK61_RS18150	COG3343	RNA polymerase activity
FLK61_RS18165	COG1703	isobutyryl-CoA mutase activity
FLK61_RS18170	COG1960	acyl-CoA dehydrogenase activity
FLK61_RS18175	COG1960	acyl-CoA dehydrogenase activity
FLK61_RS18180	COG1250	3-hydroxyacyl-CoA dehydrogenase
FLK61_RS18185	COG0183	Belongs to the thiolase family
FLK61_RS18200	COG2181	nitrate reductase activity
FLK61_RS18200	COG0247	lactate metabolic process
FLK61_RS18205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FLK61_RS18215	COG0596	Alpha beta hydrolase
FLK61_RS18235	COG0018	arginyl-trna synthetase
FLK61_RS18255	COG0010	Belongs to the arginase family
FLK61_RS18260	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FLK61_RS18275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FLK61_RS18290	COG1942	4-Oxalocrotonate Tautomerase
FLK61_RS18300	COG0384	phenazine biosynthesis protein PhzF
FLK61_RS18310	COG3465	dGTPase activity
FLK61_RS18315	COG1078	dGTPase activity
FLK61_RS18320	COG0095	Lipoate-protein ligase
FLK61_RS18340	COG2239	Acts as a magnesium transporter
FLK61_RS18345	COG1361	Conserved repeat domain
FLK61_RS18355	COG1609	Transcriptional regulator
FLK61_RS18365	COG1069	ribulokinase activity
FLK61_RS18385	COG0395	ABC-type sugar transport system, permease component
FLK61_RS18390	COG1175	transmembrane transport
FLK61_RS18395	COG1653	transport
FLK61_RS18400	COG1361	Conserved repeat domain
FLK61_RS18400	COG2911	Protein conserved in bacteria
FLK61_RS18400	COG3266	domain, Protein
FLK61_RS18435	COG0280	phosphate acetyltransferase
FLK61_RS18440	COG1902	pentaerythritol trinitrate reductase activity
FLK61_RS18440	COG0446	pyridine nucleotide-disulphide oxidoreductase
FLK61_RS18445	COG1024	Enoyl-CoA hydratase
FLK61_RS18455	COG1737	Transcriptional regulator
FLK61_RS18470	COG0395	ABC-type sugar transport system, permease component
FLK61_RS18475	COG1175	transmembrane transport
FLK61_RS18500	COG1940	carbohydrate kinase activity
FLK61_RS18515	COG3773	Cell wall hydrolase
FLK61_RS18525	COG2363	Small membrane protein
FLK61_RS18530	COG0456	acetyltransferase
FLK61_RS18550	COG0702	epimerase
FLK61_RS18555	COG3852	Histidine kinase
FLK61_RS18560	COG2084	Dehydrogenase
FLK61_RS18565	COG0656	L-ascorbic acid biosynthetic process
FLK61_RS18570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FLK61_RS18575	COG2201	protein-glutamate methylesterase activity
FLK61_RS18580	COG1621	beta-fructofuranosidase activity
FLK61_RS18585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FLK61_RS18590	COG0840	transmembrane signaling receptor activity
FLK61_RS18605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FLK61_RS18625	COG1368	sulfuric ester hydrolase activity
FLK61_RS18630	COG2309	aminopeptidase activity
FLK61_RS18635	COG0024	Methionine aminopeptidase
FLK61_RS18640	COG1115	amino acid carrier protein
FLK61_RS18655	COG1072	(Pantothenic acid kinase))
FLK61_RS18670	COG2308	Evidence 4 Homologs of previously reported genes of
FLK61_RS18675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FLK61_RS18675	COG0723	plastoquinol--plastocyanin reductase activity
FLK61_RS18680	COG1473	amidohydrolase
FLK61_RS18710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FLK61_RS18750	COG3046	protein related to deoxyribodipyrimidine photolyase
FLK61_RS18755	COG5002	protein histidine kinase activity
FLK61_RS18760	COG0745	RESPONSE REGULATOR receiver
FLK61_RS18780	COG0460	homoserine dehydrogenase
FLK61_RS18785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FLK61_RS18790	COG0083	homoserine kinase activity
FLK61_RS18795	COG0778	Nitroreductase
FLK61_RS18805	COG0561	phosphatase activity
FLK61_RS18810	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FLK61_RS18825	COG0527	aspartate kinase activity
FLK61_RS18830	COG0747	negative chemotaxis
FLK61_RS18840	COG0601	transmembrane transport
FLK61_RS18845	COG0444	Belongs to the ABC transporter superfamily
FLK61_RS18850	COG4608	Belongs to the ABC transporter superfamily
FLK61_RS18870	COG3842	ATPase activity
FLK61_RS18875	COG3833	ABC-type maltose transport systems, permease component
FLK61_RS18885	COG4134	Bacterial extracellular solute-binding protein
FLK61_RS18895	COG1607	acyl-coa hydrolase
FLK61_RS18910	COG0493	'glutamate synthase
FLK61_RS18915	COG0069	glutamate synthase activity
FLK61_RS18915	COG0070	glutamate synthase
FLK61_RS18915	COG0067	glutamate synthase
FLK61_RS18925	COG1090	epimerase
FLK61_RS18930	COG1119	ATPase activity
FLK61_RS18940	COG1126	abc transporter atp-binding protein
FLK61_RS18945	COG0765	amino acid transport
FLK61_RS18950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FLK61_RS18960	COG1115	amino acid carrier protein
FLK61_RS18965	COG0655	NAD(P)H dehydrogenase (quinone) activity
FLK61_RS18970	COG1404	Belongs to the peptidase S8 family
FLK61_RS18990	COG2223	nitrite transmembrane transporter activity
FLK61_RS19000	COG0726	polysaccharide deacetylase
FLK61_RS19015	COG2267	carboxylic ester hydrolase activity
FLK61_RS19030	COG5001	Diguanylate cyclase
FLK61_RS19030	COG3300	MHYT domain
FLK61_RS19035	COG0446	pyridine nucleotide-disulphide oxidoreductase
FLK61_RS19050	COG1012	belongs to the aldehyde dehydrogenase family
FLK61_RS19055	COG1070	Carbohydrate kinase
FLK61_RS19060	COG2115	Belongs to the xylose isomerase family
FLK61_RS19070	COG1028	Short-chain dehydrogenase reductase Sdr
FLK61_RS19080	COG1802	Transcriptional regulator
FLK61_RS19090	COG0395	ABC-type sugar transport system, permease component
FLK61_RS19095	COG4209	transmembrane transport
FLK61_RS19100	COG1653	transport
FLK61_RS19105	COG5578	integral membrane protein
FLK61_RS19115	COG2972	Histidine kinase
FLK61_RS19125	COG1653	transport
FLK61_RS19135	COG0395	ABC-type sugar transport system, permease component
FLK61_RS19140	COG3507	Belongs to the glycosyl hydrolase 43 family
FLK61_RS19145	COG5578	integral membrane protein
FLK61_RS19150	COG3693	PFAM glycoside hydrolase, family 10
FLK61_RS19175	COG2182	Extracellular solute-binding protein
FLK61_RS19180	COG1175	transmembrane transport
FLK61_RS19185	COG3833	ABC-type maltose transport systems, permease component
FLK61_RS19190	COG1874	Beta-galactosidase
FLK61_RS19200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FLK61_RS19230	COG0745	RESPONSE REGULATOR receiver
FLK61_RS19245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FLK61_RS19265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FLK61_RS19270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FLK61_RS19275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FLK61_RS19290	COG1307	EDD domain protein, DegV family
FLK61_RS19300	COG0789	Transcriptional regulator
FLK61_RS19305	COG0840	transmembrane signaling receptor activity
FLK61_RS19310	COG1609	Transcriptional regulator
FLK61_RS19325	COG0454	-acetyltransferase
FLK61_RS19365	COG2205	protein histidine kinase activity
FLK61_RS19370	COG0745	RESPONSE REGULATOR receiver
FLK61_RS19375	COG1136	(ABC) transporter
FLK61_RS19380	COG0577	efflux transmembrane transporter activity
FLK61_RS19395	COG0730	response to heat
FLK61_RS19400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FLK61_RS19400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FLK61_RS19405	COG2210	Belongs to the sulfur carrier protein TusA family
FLK61_RS19410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FLK61_RS19410	COG0425	Belongs to the sulfur carrier protein TusA family
FLK61_RS19445	COG0688	phosphatidylethanolamine metabolic process
FLK61_RS19455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FLK61_RS19475	COG0456	acetyltransferase
FLK61_RS19485	COG2814	Major facilitator Superfamily
FLK61_RS19490	COG1309	transcriptional regulator
FLK61_RS19495	COG0745	RESPONSE REGULATOR receiver
FLK61_RS19505	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FLK61_RS19510	COG1061	Type III restriction enzyme res subunit
FLK61_RS19535	COG2226	methyltransferase
FLK61_RS19540	COG2207	Transcriptional regulator
FLK61_RS19540	COG3708	Transcriptional regulator
FLK61_RS19550	COG1834	amidinotransferase
FLK61_RS19555	COG3403	YqcI/YcgG family
FLK61_RS19565	COG1595	DNA-templated transcription, initiation
FLK61_RS19640	COG1401	restriction endodeoxyribonuclease activity
FLK61_RS19660	COG2801	Transposase and inactivated derivatives
FLK61_RS19685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FLK61_RS19725	COG0415	Belongs to the DNA photolyase family
FLK61_RS19735	COG3706	GGDEF domain
FLK61_RS19750	COG0747	negative chemotaxis
FLK61_RS19755	COG4608	Belongs to the ABC transporter superfamily
FLK61_RS19760	COG0444	Belongs to the ABC transporter superfamily
FLK61_RS19765	COG1012	belongs to the aldehyde dehydrogenase family
FLK61_RS19785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FLK61_RS19790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FLK61_RS19795	COG4853	Protein conserved in bacteria
FLK61_RS19800	COG4863	YycH protein
FLK61_RS19805	COG5002	protein histidine kinase activity
FLK61_RS19810	COG0745	RESPONSE REGULATOR receiver
FLK61_RS19840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FLK61_RS19845	COG0305	Participates in initiation and elongation during chromosome replication
FLK61_RS19850	COG0359	binds to the 23S rRNA
FLK61_RS19855	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FLK61_RS19860	COG4241	membrane
FLK61_RS19870	COG1174	glycine betaine transport
FLK61_RS19875	COG1125	glycine betaine transport
FLK61_RS19875	COG0517	IMP dehydrogenase activity
FLK61_RS19885	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FLK61_RS19890	COG0629	single-stranded DNA binding
FLK61_RS19895	COG0360	Binds together with S18 to 16S ribosomal RNA
FLK61_RS19900	COG0012	GTP binding
FLK61_RS19905	COG4481	Protein conserved in bacteria
FLK61_RS19910	COG3949	Membrane
FLK61_RS19920	COG1811	Na channel or pump
FLK61_RS19925	COG1475	DNA binding
FLK61_RS19930	COG1192	Involved in chromosome partitioning
FLK61_RS19935	COG1475	DNA binding
FLK61_RS19940	COG0357	Ribosomal RNA small subunit methyltransferase G
FLK61_RS19945	COG0445	tRNA wobble uridine modification
FLK61_RS19950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FLK61_RS19955	COG1847	R3H domain protein
FLK61_RS19960	COG0706	membrane insertase activity
FLK61_RS19965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FLK61_RS19975	COG0230	Belongs to the bacterial ribosomal protein bL34 family