locus-tag	class	description
GNK04_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GNK04_RS00010	COG0592	DNA-directed DNA polymerase activity
GNK04_RS00015	COG2501	S4 domain
GNK04_RS00030	COG0187	DNA topoisomerase II activity
GNK04_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GNK04_RS00060	COG0517	IMP dehydrogenase activity
GNK04_RS00060	COG0516	GMP reductase activity
GNK04_RS00070	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GNK04_RS00075	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GNK04_RS00080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GNK04_RS00090	COG1428	Deoxynucleoside kinase
GNK04_RS00095	COG1428	Deoxynucleoside kinase
GNK04_RS00105	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GNK04_RS00110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GNK04_RS00115	COG0179	Fumarylacetoacetate (FAA) hydrolase
GNK04_RS00140	COG1335	isochorismatase
GNK04_RS00145	COG0590	tRNA wobble adenosine to inosine editing
GNK04_RS00160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GNK04_RS00165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GNK04_RS00170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GNK04_RS00205	COG1982	Orn Lys Arg decarboxylase major
GNK04_RS00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GNK04_RS00215	COG3870	Protein conserved in bacteria
GNK04_RS00220	COG0470	DNA polymerase III
GNK04_RS00225	COG1774	PSP1 C-terminal conserved region
GNK04_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GNK04_RS00240	COG2827	Endonuclease containing a URI domain
GNK04_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GNK04_RS00250	COG2002	toxin-antitoxin pair type II binding
GNK04_RS00260	COG0084	hydrolase, TatD family'
GNK04_RS00265	COG3583	domain protein
GNK04_RS00265	COG3584	3D domain protein
GNK04_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GNK04_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GNK04_RS00285	COG4466	Protein conserved in bacteria
GNK04_RS00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GNK04_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GNK04_RS00305	COG0251	oxidation-reduction process
GNK04_RS00310	COG2088	sporulation resulting in formation of a cellular spore
GNK04_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GNK04_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GNK04_RS00345	COG2002	toxin-antitoxin pair type II binding
GNK04_RS00350	COG2244	polysaccharide biosynthetic process
GNK04_RS00355	COG3956	TIGRFAM MazG family protein
GNK04_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GNK04_RS00380	COG1098	S1 RNA binding domain
GNK04_RS00395	COG2208	phosphoserine phosphatase activity
GNK04_RS00400	COG2304	oxidoreductase activity
GNK04_RS00405	COG0515	serine threonine protein kinase
GNK04_RS00410	COG0037	tRNA processing
GNK04_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GNK04_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GNK04_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GNK04_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
GNK04_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GNK04_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GNK04_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GNK04_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GNK04_RS00470	COG1396	sequence-specific DNA binding
GNK04_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GNK04_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GNK04_RS00570	COG3880	PFAM UvrB UvrC protein
GNK04_RS00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GNK04_RS00580	COG0542	response to heat
GNK04_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GNK04_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GNK04_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
GNK04_RS00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GNK04_RS00615	COG1045	serine acetyltransferase
GNK04_RS00620	COG0215	cysteine-tRNA ligase activity
GNK04_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GNK04_RS00635	COG3688	RNA-binding protein containing a PIN domain
GNK04_RS00645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GNK04_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GNK04_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
GNK04_RS00660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GNK04_RS00665	COG0081	regulation of translation
GNK04_RS00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GNK04_RS00675	COG0222	ribosome binding
GNK04_RS00680	COG2813	Specifically methylates the guanine in position
GNK04_RS00685	COG0085	RNA polymerase activity
GNK04_RS00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GNK04_RS00695	COG1358	cellular component organization or biogenesis
GNK04_RS00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GNK04_RS00705	COG0049	tRNA binding
GNK04_RS00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GNK04_RS00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GNK04_RS00720	COG0051	transcription antitermination factor activity, RNA binding
GNK04_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GNK04_RS00730	COG0088	Forms part of the polypeptide exit tunnel
GNK04_RS00735	COG0089	rRNA binding
GNK04_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GNK04_RS00745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GNK04_RS00750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GNK04_RS00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GNK04_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GNK04_RS00765	COG0255	Belongs to the universal ribosomal protein uL29 family
GNK04_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GNK04_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GNK04_RS00780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GNK04_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GNK04_RS00790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GNK04_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GNK04_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GNK04_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GNK04_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GNK04_RS00815	COG1841	ribosomal large subunit assembly
GNK04_RS00825	COG0201	protein transport
GNK04_RS00830	COG0563	adenylate kinase activity
GNK04_RS00835	COG0024	Methionine aminopeptidase
GNK04_RS00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GNK04_RS00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GNK04_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GNK04_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GNK04_RS00865	COG0202	RNA polymerase activity
GNK04_RS00870	COG0203	ribosomal protein L17
GNK04_RS00875	COG1122	ATPase activity
GNK04_RS00890	COG0101	tRNA pseudouridine synthase activity
GNK04_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GNK04_RS00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS00915	COG0489	protein tyrosine kinase activity
GNK04_RS00925	COG2194	sulfuric ester hydrolase activity
GNK04_RS00930	COG0726	polysaccharide deacetylase
GNK04_RS01015	COG1595	DNA-templated transcription, initiation
GNK04_RS01020	COG5662	AntiSigma factor
GNK04_RS01025	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GNK04_RS01030	COG4856	YbbR-like protein
GNK04_RS01035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GNK04_RS01040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GNK04_RS01055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GNK04_RS01065	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GNK04_RS01105	COG1280	lysine exporter protein (LysE YggA)
GNK04_RS01110	COG3403	YqcI/YcgG family
GNK04_RS01115	COG1113	amino acid transport
GNK04_RS01125	COG1937	Protein conserved in bacteria
GNK04_RS01130	COG2217	Heavy metal translocating P-type atpase
GNK04_RS01155	COG3711	transcriptional antiterminator
GNK04_RS01165	COG0246	Mannitol dehydrogenase
GNK04_RS01175	COG1607	acyl-coa hydrolase
GNK04_RS01185	COG2861	carbohydrate metabolic process
GNK04_RS01190	COG1268	BioY protein
GNK04_RS01200	COG4989	oxidoreductase activity
GNK04_RS01215	COG0006	proline dipeptidase activity
GNK04_RS01220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GNK04_RS01225	COG3118	belongs to the thioredoxin family
GNK04_RS01230	COG4221	oxidoreductase activity
GNK04_RS01240	COG1970	mechanosensitive ion channel activity
GNK04_RS01255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNK04_RS01265	COG0446	pyridine nucleotide-disulphide oxidoreductase
GNK04_RS01265	COG1902	pentaerythritol trinitrate reductase activity
GNK04_RS01270	COG1307	EDD domain protein, DegV family
GNK04_RS01275	COG4294	response to UV
GNK04_RS01285	COG0604	alcohol dehydrogenase
GNK04_RS01290	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GNK04_RS01300	COG3402	PFAM membrane-flanked domain
GNK04_RS01305	COG3428	Bacterial PH domain
GNK04_RS01330	COG0705	Rhomboid family
GNK04_RS01335	COG0736	holo-[acyl-carrier-protein] synthase activity
GNK04_RS01340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GNK04_RS01340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GNK04_RS01345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GNK04_RS01355	COG0864	Transcriptional regulator
GNK04_RS01360	COG2337	Toxic component of a toxin-antitoxin (TA) module
GNK04_RS01365	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS01370	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS01375	COG2172	sigma factor antagonist activity
GNK04_RS01380	COG2208	phosphoserine phosphatase activity
GNK04_RS01385	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS01390	COG2172	sigma factor antagonist activity
GNK04_RS01395	COG1191	sigma factor activity
GNK04_RS01400	COG2208	phosphoserine phosphatase activity
GNK04_RS01405	COG2183	response to ionizing radiation
GNK04_RS01415	COG3091	SprT-like family
GNK04_RS01495	COG0626	cystathionine gamma-synthase activity
GNK04_RS01510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GNK04_RS01515	COG0802	atpase or kinase
GNK04_RS01520	COG1214	PFAM Peptidase M22, glycoprotease
GNK04_RS01525	COG0456	acetyltransferase
GNK04_RS01535	COG0488	(ABC) transporter
GNK04_RS01545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GNK04_RS01550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GNK04_RS01555	COG0805	protein transport
GNK04_RS01565	COG1266	CAAX protease self-immunity
GNK04_RS01570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GNK04_RS01575	COG0459	protein refolding
GNK04_RS01580	COG1620	l-lactate permease
GNK04_RS01585	COG2186	Transcriptional regulator
GNK04_RS01590	COG0247	lactate metabolic process
GNK04_RS01595	COG1139	Iron-sulfur cluster binding protein
GNK04_RS01600	COG1556	Lactate utilization protein
GNK04_RS01625	COG1063	alcohol dehydrogenase
GNK04_RS01630	COG0714	Associated with various cellular activities
GNK04_RS01635	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GNK04_RS01640	COG1305	Transglutaminase-like
GNK04_RS01645	COG0519	Catalyzes the synthesis of GMP from XMP
GNK04_RS01645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GNK04_RS01650	COG2252	PERMEase
GNK04_RS01680	COG1733	regulation of RNA biosynthetic process
GNK04_RS01685	COG2514	catechol 2,3-dioxygenase activity
GNK04_RS01695	COG0831	urea catabolic process
GNK04_RS01740	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GNK04_RS01750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GNK04_RS01755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GNK04_RS01760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GNK04_RS01765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GNK04_RS01770	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GNK04_RS01785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GNK04_RS01790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GNK04_RS01795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GNK04_RS01800	COG0138	bifunctional purine biosynthesis protein purh
GNK04_RS01805	COG0151	Belongs to the GarS family
GNK04_RS01815	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GNK04_RS01820	COG4496	protein, YerC YecD
GNK04_RS01825	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GNK04_RS01830	COG0210	DNA helicase
GNK04_RS01835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GNK04_RS01840	COG4851	CamS sex pheromone cAM373 precursor
GNK04_RS01855	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GNK04_RS01860	COG0154	amidase activity
GNK04_RS01865	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GNK04_RS01870	COG1597	lipid kinase activity
GNK04_RS01875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GNK04_RS01885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GNK04_RS01890	COG0561	phosphatase activity
GNK04_RS01895	COG0702	epimerase
GNK04_RS01915	COG0583	DNA-binding transcription factor activity
GNK04_RS01920	COG2197	response regulator
GNK04_RS01925	COG4585	Histidine kinase
GNK04_RS01930	COG3239	Fatty acid desaturase
GNK04_RS01935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GNK04_RS01940	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GNK04_RS01945	COG1733	regulation of RNA biosynthetic process
GNK04_RS01960	COG1620	l-lactate permease
GNK04_RS01965	COG0039	L-malate dehydrogenase activity
GNK04_RS01980	COG1966	Carbon starvation protein
GNK04_RS01985	COG3279	Response regulator of the LytR AlgR family
GNK04_RS01990	COG3275	phosphorelay sensor kinase activity
GNK04_RS01995	COG3829	transcription factor binding
GNK04_RS02000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GNK04_RS02005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GNK04_RS02025	COG2267	carboxylic ester hydrolase activity
GNK04_RS02030	COG1609	Transcriptional regulator
GNK04_RS02045	COG0395	ABC-type sugar transport system, permease component
GNK04_RS02050	COG2723	6-phospho-beta-galactosidase activity
GNK04_RS02065	COG3711	transcriptional antiterminator
GNK04_RS02065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNK04_RS02070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNK04_RS02070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNK04_RS02070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNK04_RS02080	COG2304	oxidoreductase activity
GNK04_RS02085	COG2310	stress, protein
GNK04_RS02090	COG2310	stress, protein
GNK04_RS02095	COG2310	stress, protein
GNK04_RS02100	COG0861	Integral membrane protein TerC family
GNK04_RS02115	COG1358	cellular component organization or biogenesis
GNK04_RS02130	COG3853	Toxic anion resistance protein (TelA)
GNK04_RS02140	COG1115	amino acid carrier protein
GNK04_RS02150	COG2966	Psort location CytoplasmicMembrane, score
GNK04_RS02155	COG3610	response to peptide
GNK04_RS02160	COG2259	Doxx family
GNK04_RS02165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GNK04_RS02170	COG1607	acyl-coa hydrolase
GNK04_RS02175	COG0628	permease
GNK04_RS02180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNK04_RS02185	COG0446	pyridine nucleotide-disulphide oxidoreductase
GNK04_RS02190	COG0406	alpha-ribazole phosphatase activity
GNK04_RS02195	COG1115	amino acid carrier protein
GNK04_RS02200	COG2814	Major facilitator Superfamily
GNK04_RS02205	COG1846	Transcriptional regulator
GNK04_RS02210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GNK04_RS02210	COG0723	plastoquinol--plastocyanin reductase activity
GNK04_RS02215	COG0488	(ABC) transporter
GNK04_RS02220	COG2356	endonuclease I
GNK04_RS02235	COG0300	oxidoreductase activity
GNK04_RS02270	COG3973	AAA domain
GNK04_RS02280	COG4895	conserved protein (DUF2196)
GNK04_RS02305	COG4585	Histidine kinase
GNK04_RS02310	COG2197	response regulator
GNK04_RS02315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNK04_RS02325	COG2130	NADP-dependent
GNK04_RS02330	COG3361	conserved protein (COG2071)
GNK04_RS02335	COG2962	Rard protein
GNK04_RS02375	COG1254	Belongs to the acylphosphatase family
GNK04_RS02380	COG5522	Integral membrane protein (intg_mem_TP0381)
GNK04_RS02385	COG2202	Pas domain
GNK04_RS02385	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS02390	COG2200	EAL domain
GNK04_RS02395	COG0432	Pfam Uncharacterised protein family UPF0047
GNK04_RS02400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GNK04_RS02415	COG1295	ribonuclease BN
GNK04_RS02420	COG2217	Heavy metal translocating P-type atpase
GNK04_RS02440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNK04_RS02445	COG0477	Major facilitator Superfamily
GNK04_RS02455	COG3871	stress protein (general stress protein 26)
GNK04_RS02460	COG0534	Mate efflux family protein
GNK04_RS02465	COG2364	Membrane
GNK04_RS02480	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GNK04_RS02485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GNK04_RS02505	COG1228	amidohydrolase
GNK04_RS02510	COG1090	epimerase
GNK04_RS02515	COG2137	regulation of response to DNA damage stimulus
GNK04_RS02520	COG4221	oxidoreductase activity
GNK04_RS02545	COG1988	membrane-bound metal-dependent
GNK04_RS02550	COG1194	a g-specific adenine glycosylase
GNK04_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS02570	COG2135	peptidase activity
GNK04_RS02580	COG3557	Belongs to the UPF0374 family
GNK04_RS02585	COG1132	(ABC) transporter
GNK04_RS02590	COG0444	Belongs to the ABC transporter superfamily
GNK04_RS02595	COG4608	Belongs to the ABC transporter superfamily
GNK04_RS02600	COG0747	negative chemotaxis
GNK04_RS02615	COG4129	membrane
GNK04_RS02625	COG4555	ABC transporter
GNK04_RS02660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GNK04_RS02670	COG2096	Adenosyltransferase
GNK04_RS02675	COG0735	belongs to the Fur family
GNK04_RS02790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GNK04_RS02800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNK04_RS02800	COG0072	phenylalanine-tRNA ligase activity
GNK04_RS02810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GNK04_RS02815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GNK04_RS02820	COG2364	Membrane
GNK04_RS02840	COG2766	serine protein kinase
GNK04_RS02850	COG2718	Belongs to the UPF0229 family
GNK04_RS02855	COG2333	competence protein COMEC
GNK04_RS02855	COG0658	competence protein
GNK04_RS02860	COG0517	IMP dehydrogenase activity
GNK04_RS02865	COG3153	acetyltransferase
GNK04_RS02865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GNK04_RS02870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GNK04_RS02880	COG1937	Protein conserved in bacteria
GNK04_RS02885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNK04_RS02900	COG0668	transmembrane transport
GNK04_RS02905	COG0385	Bile acid
GNK04_RS02910	COG2719	SpoVR family
GNK04_RS02925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GNK04_RS02950	COG3842	ATPase activity
GNK04_RS02955	COG2508	Transcriptional regulator
GNK04_RS02975	COG0189	ligase activity
GNK04_RS02980	COG0189	ligase activity
GNK04_RS02995	COG3679	Belongs to the UPF0342 family
GNK04_RS03005	COG0561	phosphatase activity
GNK04_RS03010	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS03020	COG4152	abc transporter atp-binding protein
GNK04_RS03025	COG1668	transmembrane transport
GNK04_RS03035	COG4717	serine-type aminopeptidase activity
GNK04_RS03040	COG0745	RESPONSE REGULATOR receiver
GNK04_RS03045	COG2205	protein histidine kinase activity
GNK04_RS03045	COG2770	Histidine kinase
GNK04_RS03050	COG3481	metal-dependent phosphohydrolase, HD sub domain
GNK04_RS03065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GNK04_RS03090	COG1846	Transcriptional regulator
GNK04_RS03105	COG3339	Conserved Protein
GNK04_RS03115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GNK04_RS03125	COG0537	adenosine 5'-monophosphoramidase activity
GNK04_RS03130	COG1131	(ABC) transporter
GNK04_RS03135	COG4473	ABC transporter
GNK04_RS03150	COG0693	protein deglycase activity
GNK04_RS03160	COG0671	phosphoesterase, PA-phosphatase related
GNK04_RS03165	COG1597	lipid kinase activity
GNK04_RS03170	COG2116	formate transmembrane transporter activity
GNK04_RS03180	COG2329	Antibiotic biosynthesis monooxygenase
GNK04_RS03185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GNK04_RS03190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GNK04_RS03205	COG2205	protein histidine kinase activity
GNK04_RS03210	COG1309	transcriptional regulator
GNK04_RS03215	COG1511	domain protein
GNK04_RS03220	COG0517	IMP dehydrogenase activity
GNK04_RS03220	COG1125	glycine betaine transport
GNK04_RS03230	COG1732	Glycine betaine
GNK04_RS03235	COG2113	Glycine betaine
GNK04_RS03240	COG4176	ABC-type proline glycine betaine transport system permease component
GNK04_RS03245	COG4175	Glycine betaine
GNK04_RS03245	COG0517	IMP dehydrogenase activity
GNK04_RS03250	COG1510	regulation of RNA biosynthetic process
GNK04_RS03255	COG1126	abc transporter atp-binding protein
GNK04_RS03265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GNK04_RS03270	COG2390	Transcriptional regulator
GNK04_RS03275	COG1234	tRNA 3'-trailer cleavage
GNK04_RS03290	COG0095	Lipoate-protein ligase
GNK04_RS03295	COG0318	PFAM AMP-dependent synthetase and ligase
GNK04_RS03300	COG3396	Phenylacetate-CoA oxygenase
GNK04_RS03315	COG2151	metal-sulfur cluster biosynthetic enzyme
GNK04_RS03325	COG1024	Enoyl-CoA hydratase
GNK04_RS03330	COG1024	Enoyl-CoA hydratase
GNK04_RS03335	COG3327	negative regulation of DNA-templated transcription, initiation
GNK04_RS03355	COG4120	Belongs to the binding-protein-dependent transport system permease family
GNK04_RS03360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GNK04_RS03375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GNK04_RS03385	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNK04_RS03390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GNK04_RS03395	COG1476	TRANSCRIPTIONal
GNK04_RS03400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GNK04_RS03410	COG0561	phosphatase activity
GNK04_RS03420	COG0501	Belongs to the peptidase M48B family
GNK04_RS03430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNK04_RS03435	COG4325	translation initiation factor activity
GNK04_RS03455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNK04_RS03460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GNK04_RS03505	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GNK04_RS03515	COG0542	response to heat
GNK04_RS03535	COG0604	alcohol dehydrogenase
GNK04_RS03555	COG0494	nUDIX hydrolase
GNK04_RS03575	COG1595	DNA-templated transcription, initiation
GNK04_RS03585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNK04_RS03620	COG1595	DNA-templated transcription, initiation
GNK04_RS03625	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS03650	COG0697	spore germination
GNK04_RS03660	COG0018	arginyl-trna synthetase
GNK04_RS03665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GNK04_RS03675	COG3336	cytochrome c oxidase
GNK04_RS03680	COG0640	Transcriptional regulator
GNK04_RS03690	COG2816	NAD+ diphosphatase activity
GNK04_RS03695	COG0640	Transcriptional regulator
GNK04_RS03700	COG0300	oxidoreductase activity
GNK04_RS03705	COG1999	signal sequence binding
GNK04_RS03710	COG0473	3-isopropylmalate dehydrogenase activity
GNK04_RS03730	COG0431	NADPH-dependent FMN reductase
GNK04_RS03735	COG2197	response regulator
GNK04_RS03740	COG2203	Gaf domain
GNK04_RS03740	COG4585	Histidine kinase
GNK04_RS03745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GNK04_RS03750	COG0589	response to stress
GNK04_RS03755	COG1476	TRANSCRIPTIONal
GNK04_RS03775	COG0456	acetyltransferase
GNK04_RS03785	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GNK04_RS03790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GNK04_RS03795	COG2610	gluconate transmembrane transporter activity
GNK04_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS03825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNK04_RS03830	COG4166	transmembrane transport
GNK04_RS03835	COG0154	amidase activity
GNK04_RS03840	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GNK04_RS03850	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS03855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNK04_RS03875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNK04_RS03880	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GNK04_RS03885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GNK04_RS03900	COG0584	glycerophosphoryl diester phosphodiesterase
GNK04_RS03910	COG1172	Belongs to the binding-protein-dependent transport system permease family
GNK04_RS03915	COG1129	ABC transporter
GNK04_RS03920	COG1879	ABC-type sugar transport system periplasmic component
GNK04_RS03925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GNK04_RS03930	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GNK04_RS03935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GNK04_RS03940	COG0436	Aminotransferase
GNK04_RS03945	COG1850	ribulose-bisphosphate carboxylase activity
GNK04_RS03950	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GNK04_RS03955	COG0235	Class ii aldolase
GNK04_RS03960	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GNK04_RS03965	COG1247	-acetyltransferase
GNK04_RS03975	COG5002	protein histidine kinase activity
GNK04_RS04000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GNK04_RS04040	COG2986	histidine ammonia-lyase
GNK04_RS04045	COG1522	sequence-specific DNA binding
GNK04_RS04050	COG0436	Aminotransferase
GNK04_RS04060	COG0720	synthase
GNK04_RS04065	COG0602	queuosine metabolic process
GNK04_RS04070	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GNK04_RS04075	COG0372	Belongs to the citrate synthase family
GNK04_RS04080	COG0583	DNA-binding transcription factor activity
GNK04_RS04095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNK04_RS04105	COG1309	transcriptional regulator
GNK04_RS04110	COG2076	Multidrug Resistance protein
GNK04_RS04115	COG2076	Multidrug Resistance protein
GNK04_RS04120	COG0488	(ABC) transporter
GNK04_RS04125	COG2746	aminoglycoside 3-N-acetyltransferase activity
GNK04_RS04130	COG4191	Histidine kinase
GNK04_RS04150	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS04195	COG0586	Pfam SNARE associated Golgi protein
GNK04_RS04215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GNK04_RS04220	COG0519	Catalyzes the synthesis of GMP from XMP
GNK04_RS04235	COG1051	belongs to the nudix hydrolase family
GNK04_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS04250	COG0028	Belongs to the TPP enzyme family
GNK04_RS04255	COG2105	PFAM AIG2 family protein
GNK04_RS04280	COG0438	transferase activity, transferring glycosyl groups
GNK04_RS04290	COG2211	Major facilitator Superfamily
GNK04_RS04300	COG1476	TRANSCRIPTIONal
GNK04_RS04320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GNK04_RS04335	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GNK04_RS04345	COG1335	isochorismatase
GNK04_RS04350	COG1764	response to oxidative stress
GNK04_RS04355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNK04_RS04385	COG0582	viral genome integration into host DNA
GNK04_RS04390	COG3263	regulation of cellular component size
GNK04_RS04400	COG1609	Transcriptional regulator
GNK04_RS04405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GNK04_RS04410	COG1869	D-ribose catabolic process
GNK04_RS04415	COG1129	ABC transporter
GNK04_RS04420	COG1172	Belongs to the binding-protein-dependent transport system permease family
GNK04_RS04425	COG1879	ABC-type sugar transport system periplasmic component
GNK04_RS04430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GNK04_RS04435	COG0667	Aldo Keto reductase
GNK04_RS04475	COG0477	Major facilitator Superfamily
GNK04_RS04480	COG1368	sulfuric ester hydrolase activity
GNK04_RS04485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNK04_RS04495	COG1278	Cold shock
GNK04_RS04500	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS04510	COG2376	Dihydroxyacetone kinase
GNK04_RS04520	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GNK04_RS04535	COG1063	alcohol dehydrogenase
GNK04_RS04540	COG1994	Peptidase M50
GNK04_RS04545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNK04_RS04550	COG2814	Major facilitator Superfamily
GNK04_RS04580	COG3284	Transcriptional regulator
GNK04_RS04585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GNK04_RS04590	COG0022	dehydrogenase e1 component
GNK04_RS04595	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNK04_RS04605	COG0579	oxidoreductase
GNK04_RS04610	COG2819	hydrolase of the alpha beta superfamily
GNK04_RS04620	COG1595	DNA-templated transcription, initiation
GNK04_RS04640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GNK04_RS04645	COG3290	protein histidine kinase activity
GNK04_RS04650	COG4565	transcriptional regulatory protein
GNK04_RS04670	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS04675	COG2508	Transcriptional regulator
GNK04_RS04680	COG0506	proline dehydrogenase activity
GNK04_RS04685	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS04695	COG5002	protein histidine kinase activity
GNK04_RS04705	COG2226	methyltransferase
GNK04_RS04710	COG2226	methyltransferase
GNK04_RS04715	COG0861	Integral membrane protein TerC family
GNK04_RS04725	COG0124	histidyl-tRNA synthetase
GNK04_RS04755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GNK04_RS04760	COG1393	Belongs to the ArsC family
GNK04_RS04765	COG2814	Major facilitator Superfamily
GNK04_RS04805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNK04_RS04815	COG1126	abc transporter atp-binding protein
GNK04_RS04825	COG3300	MHYT domain
GNK04_RS04825	COG5001	Diguanylate cyclase
GNK04_RS04830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GNK04_RS04835	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS04845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNK04_RS04850	COG3340	Belongs to the peptidase S51 family
GNK04_RS04860	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS04865	COG1733	regulation of RNA biosynthetic process
GNK04_RS04870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GNK04_RS04880	COG2814	Major facilitator Superfamily
GNK04_RS04885	COG3829	transcription factor binding
GNK04_RS04885	COG3290	protein histidine kinase activity
GNK04_RS04885	COG3290	protein histidine kinase activity
GNK04_RS04885	COG3829	transcription factor binding
GNK04_RS04890	COG1288	antiporter activity
GNK04_RS04895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GNK04_RS04910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GNK04_RS04915	COG1522	sequence-specific DNA binding
GNK04_RS04930	COG0590	tRNA wobble adenosine to inosine editing
GNK04_RS04935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GNK04_RS04945	COG0789	Transcriptional regulator
GNK04_RS04950	COG1253	flavin adenine dinucleotide binding
GNK04_RS04955	COG0515	serine threonine protein kinase
GNK04_RS04970	COG0785	Cytochrome C biogenesis protein
GNK04_RS04975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNK04_RS04980	COG0745	RESPONSE REGULATOR receiver
GNK04_RS04985	COG2205	protein histidine kinase activity
GNK04_RS04990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GNK04_RS04995	COG1621	beta-fructofuranosidase activity
GNK04_RS05000	COG1621	beta-fructofuranosidase activity
GNK04_RS05005	COG1621	beta-fructofuranosidase activity
GNK04_RS05015	COG3386	PFAM SMP-30 Gluconolaconase
GNK04_RS05020	COG0768	penicillin binding
GNK04_RS05030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNK04_RS05055	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNK04_RS05065	COG2207	Transcriptional regulator
GNK04_RS05075	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GNK04_RS05080	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GNK04_RS05085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNK04_RS05090	COG4191	Histidine kinase
GNK04_RS05100	COG1914	H( )-stimulated, divalent metal cation uptake system
GNK04_RS05105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GNK04_RS05110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GNK04_RS05115	COG1984	allophanate hydrolase subunit 2
GNK04_RS05120	COG0511	ligase activity, forming carbon-carbon bonds
GNK04_RS05125	COG0439	Biotin carboxylase
GNK04_RS05130	COG4336	lyase activity
GNK04_RS05155	COG1683	Conserved Protein
GNK04_RS05170	COG3655	Transcriptional regulator
GNK04_RS05180	COG5566	PFAM Mor transcription activator
GNK04_RS05210	COG5578	integral membrane protein
GNK04_RS05215	COG1609	Transcriptional regulator
GNK04_RS05220	COG4209	transmembrane transport
GNK04_RS05225	COG0395	ABC-type sugar transport system, permease component
GNK04_RS05230	COG1653	transport
GNK04_RS05235	COG1621	beta-fructofuranosidase activity
GNK04_RS05240	COG3708	Transcriptional regulator
GNK04_RS05240	COG2207	Transcriptional regulator
GNK04_RS05260	COG5577	PFAM Coat F domain
GNK04_RS05265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNK04_RS05270	COG2124	cytochrome p450
GNK04_RS05275	COG2027	D-alanyl-D-alanine carboxypeptidase
GNK04_RS05315	COG0688	phosphatidylethanolamine metabolic process
GNK04_RS05325	COG0686	Belongs to the AlaDH PNT family
GNK04_RS05330	COG2508	Transcriptional regulator
GNK04_RS05330	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GNK04_RS05335	COG0574	Belongs to the PEP-utilizing enzyme family
GNK04_RS05335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GNK04_RS05365	COG3493	citrate carrier protein
GNK04_RS05370	COG4565	transcriptional regulatory protein
GNK04_RS05375	COG3290	protein histidine kinase activity
GNK04_RS05380	COG2814	Major facilitator Superfamily
GNK04_RS05385	COG0456	acetyltransferase
GNK04_RS05385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GNK04_RS05390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNK04_RS05395	COG4605	iron ion homeostasis
GNK04_RS05400	COG4604	ABC transporter, ATP-binding protein
GNK04_RS05405	COG4607	ABC-type enterochelin transport system periplasmic component
GNK04_RS05415	COG1368	sulfuric ester hydrolase activity
GNK04_RS05460	COG2153	protein acetylation
GNK04_RS05470	COG2124	cytochrome p450
GNK04_RS05475	COG2116	formate transmembrane transporter activity
GNK04_RS05485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNK04_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS05500	COG2205	protein histidine kinase activity
GNK04_RS05515	COG0569	domain protein
GNK04_RS05520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GNK04_RS05530	COG0346	lactoylglutathione lyase activity
GNK04_RS05535	COG0640	Transcriptional regulator
GNK04_RS05540	COG0640	Transcriptional regulator
GNK04_RS05545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GNK04_RS05550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GNK04_RS05565	COG2261	transglycosylase associated protein
GNK04_RS05570	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS05590	COG0753	catalase activity
GNK04_RS05615	COG2252	PERMEase
GNK04_RS05625	COG0174	glutamine synthetase
GNK04_RS05630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GNK04_RS05635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNK04_RS05640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNK04_RS05645	COG0492	ferredoxin-NADP+ reductase activity
GNK04_RS05650	COG1120	ATPase activity
GNK04_RS05655	COG0456	acetyltransferase
GNK04_RS05660	COG0667	Aldo Keto reductase
GNK04_RS05675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GNK04_RS05690	COG0561	phosphatase activity
GNK04_RS05730	COG1785	Belongs to the alkaline phosphatase family
GNK04_RS05740	COG0673	inositol 2-dehydrogenase activity
GNK04_RS05745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GNK04_RS05755	COG1063	alcohol dehydrogenase
GNK04_RS05765	COG2610	gluconate transmembrane transporter activity
GNK04_RS05770	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS05775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNK04_RS05795	COG4221	oxidoreductase activity
GNK04_RS05810	COG1231	oxidoreductase activity
GNK04_RS05820	COG2249	NAD(P)H dehydrogenase (quinone) activity
GNK04_RS05825	COG0656	L-ascorbic acid biosynthetic process
GNK04_RS05865	COG0745	RESPONSE REGULATOR receiver
GNK04_RS05870	COG5002	protein histidine kinase activity
GNK04_RS05885	COG1335	isochorismatase
GNK04_RS05920	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS05925	COG1132	(ABC) transporter
GNK04_RS05930	COG2814	Major facilitator Superfamily
GNK04_RS05935	COG4978	Transcriptional regulator
GNK04_RS05935	COG0789	Transcriptional regulator
GNK04_RS05940	COG2814	Major facilitator Superfamily
GNK04_RS05970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GNK04_RS05975	COG1834	amidinotransferase
GNK04_RS05980	COG3403	YqcI/YcgG family
GNK04_RS06035	COG2323	membrane
GNK04_RS06085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GNK04_RS06090	COG1388	LysM domain
GNK04_RS06090	COG3942	CHAP domain
GNK04_RS06120	COG2032	superoxide dismutase activity
GNK04_RS06125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GNK04_RS06135	COG1125	glycine betaine transport
GNK04_RS06135	COG0517	IMP dehydrogenase activity
GNK04_RS06140	COG1174	glycine betaine transport
GNK04_RS06200	COG2226	methyltransferase
GNK04_RS06205	COG0583	DNA-binding transcription factor activity
GNK04_RS06230	COG2094	Belongs to the DNA glycosylase MPG family
GNK04_RS06270	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNK04_RS06290	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS06315	COG2364	Membrane
GNK04_RS06320	COG1846	Transcriptional regulator
GNK04_RS06325	COG0456	acetyltransferase
GNK04_RS06330	COG2808	Putative FMN-binding domain
GNK04_RS06340	COG2323	membrane
GNK04_RS06365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNK04_RS06375	COG0772	Belongs to the SEDS family
GNK04_RS06410	COG0745	RESPONSE REGULATOR receiver
GNK04_RS06420	COG2132	Multicopper oxidase
GNK04_RS06435	COG2132	Multicopper oxidase
GNK04_RS06440	COG1388	LysM domain
GNK04_RS06445	COG1687	branched-chain amino acid
GNK04_RS06450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GNK04_RS06465	COG1027	Aspartate ammonia-lyase
GNK04_RS06470	COG1653	transport
GNK04_RS06475	COG1175	transmembrane transport
GNK04_RS06480	COG0395	ABC-type sugar transport system, permease component
GNK04_RS06485	COG1609	Transcriptional regulator
GNK04_RS06500	COG0517	IMP dehydrogenase activity
GNK04_RS06500	COG1125	glycine betaine transport
GNK04_RS06505	COG1174	glycine betaine transport
GNK04_RS06520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNK04_RS06520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNK04_RS06520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNK04_RS06525	COG0383	alpha-mannosidase activity
GNK04_RS06535	COG1929	Belongs to the glycerate kinase type-1 family
GNK04_RS06605	COG1595	DNA-templated transcription, initiation
GNK04_RS06625	COG1131	(ABC) transporter
GNK04_RS06630	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GNK04_RS06645	COG0494	nUDIX hydrolase
GNK04_RS06655	COG1061	Type III restriction enzyme res subunit
GNK04_RS06660	COG3829	transcription factor binding
GNK04_RS06665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNK04_RS06675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GNK04_RS06685	COG1609	Transcriptional regulator
GNK04_RS06690	COG1653	transport
GNK04_RS06705	COG0366	Alpha amylase catalytic
GNK04_RS06710	COG3964	amidohydrolase
GNK04_RS06740	COG2329	Antibiotic biosynthesis monooxygenase
GNK04_RS06760	COG0640	Transcriptional regulator
GNK04_RS06765	COG3832	glyoxalase III activity
GNK04_RS06770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GNK04_RS06790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GNK04_RS06795	COG0156	8-amino-7-oxononanoate synthase activity
GNK04_RS06810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GNK04_RS06815	COG2723	6-phospho-beta-galactosidase activity
GNK04_RS06865	COG5444	nuclease activity
GNK04_RS06880	COG3973	AAA domain
GNK04_RS06885	COG1606	tRNA processing
GNK04_RS06890	COG1691	(AIR) carboxylase
GNK04_RS06895	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GNK04_RS06900	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GNK04_RS06905	COG3829	transcription factor binding
GNK04_RS06905	COG3290	protein histidine kinase activity
GNK04_RS06915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GNK04_RS06920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GNK04_RS06925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GNK04_RS06930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GNK04_RS06945	COG3835	regulator
GNK04_RS06950	COG1929	Belongs to the glycerate kinase type-1 family
GNK04_RS06960	COG3875	lactate racemase activity
GNK04_RS06965	COG2188	Transcriptional regulator
GNK04_RS06970	COG4721	ABC-type cobalt transport system, permease component
GNK04_RS06975	COG1122	ATPase activity
GNK04_RS06985	COG2045	Belongs to the ComB family
GNK04_RS06990	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GNK04_RS06995	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS07005	COG0129	dihydroxy-acid dehydratase activity
GNK04_RS07015	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GNK04_RS07020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GNK04_RS07030	COG0235	Class ii aldolase
GNK04_RS07035	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GNK04_RS07075	COG3546	catalase activity
GNK04_RS07080	COG1280	lysine exporter protein (LysE YggA)
GNK04_RS07090	COG2814	Major facilitator Superfamily
GNK04_RS07100	COG1113	amino acid transport
GNK04_RS07120	COG2226	methyltransferase
GNK04_RS07125	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS07175	COG0243	molybdopterin cofactor binding
GNK04_RS07205	COG2223	nitrite transmembrane transporter activity
GNK04_RS07215	COG2197	response regulator
GNK04_RS07225	COG4585	Histidine kinase
GNK04_RS07230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNK04_RS07235	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GNK04_RS07270	COG1595	DNA-templated transcription, initiation
GNK04_RS07280	COG1136	(ABC) transporter
GNK04_RS07285	COG0577	efflux transmembrane transporter activity
GNK04_RS07290	COG5002	protein histidine kinase activity
GNK04_RS07290	COG3850	Histidine kinase
GNK04_RS07300	COG1131	(ABC) transporter
GNK04_RS07325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GNK04_RS07330	COG0243	molybdopterin cofactor binding
GNK04_RS07335	COG2223	nitrite transmembrane transporter activity
GNK04_RS07340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GNK04_RS07345	COG2146	nitrite reductase [NAD(P)H] activity
GNK04_RS07360	COG2323	membrane
GNK04_RS07380	COG0577	efflux transmembrane transporter activity
GNK04_RS07385	COG1136	(ABC) transporter
GNK04_RS07390	COG0642	Histidine kinase
GNK04_RS07395	COG0745	RESPONSE REGULATOR receiver
GNK04_RS07410	COG2186	Transcriptional regulator
GNK04_RS07505	COG5002	protein histidine kinase activity
GNK04_RS07540	COG0456	acetyltransferase
GNK04_RS07545	COG4326	sporulation control protein
GNK04_RS07570	COG0494	nUDIX hydrolase
GNK04_RS07585	COG0392	lysyltransferase activity
GNK04_RS07585	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GNK04_RS07590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GNK04_RS07595	COG1309	transcriptional regulator
GNK04_RS07610	COG4412	M6 family metalloprotease domain protein
GNK04_RS07610	COG3291	Pkd domain containing protein
GNK04_RS07625	COG1309	transcriptional regulator
GNK04_RS07630	COG2814	Major facilitator Superfamily
GNK04_RS07640	COG0531	amino acid
GNK04_RS07645	COG0697	spore germination
GNK04_RS07650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GNK04_RS07660	COG1587	Uroporphyrinogen-III synthase
GNK04_RS07705	COG1192	Involved in chromosome partitioning
GNK04_RS07730	COG1119	ATPase activity
GNK04_RS07745	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GNK04_RS07750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GNK04_RS07755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GNK04_RS07770	COG1994	Peptidase M50
GNK04_RS07785	COG3852	Histidine kinase
GNK04_RS07800	COG1027	Aspartate ammonia-lyase
GNK04_RS07805	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS07810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GNK04_RS07825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GNK04_RS07830	COG1695	Transcriptional regulator
GNK04_RS07840	COG0697	spore germination
GNK04_RS07850	COG0659	secondary active sulfate transmembrane transporter activity
GNK04_RS07860	COG2814	Major facilitator Superfamily
GNK04_RS07865	COG1309	transcriptional regulator
GNK04_RS07870	COG2814	Major facilitator Superfamily
GNK04_RS07875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GNK04_RS07880	COG0789	Transcriptional regulator
GNK04_RS07890	COG0110	maltose O-acetyltransferase activity
GNK04_RS07895	COG1609	Transcriptional regulator
GNK04_RS07905	COG1653	transport
GNK04_RS07915	COG0395	ABC-type sugar transport system, permease component
GNK04_RS07920	COG4191	Histidine kinase
GNK04_RS07935	COG2318	DinB family
GNK04_RS07945	COG0450	alkyl hydroperoxide reductase
GNK04_RS07950	COG2226	methyltransferase
GNK04_RS07955	COG0367	asparagine synthase
GNK04_RS07990	COG1533	DNA photolyase activity
GNK04_RS08005	COG3180	Ammonia monooxygenase
GNK04_RS08055	COG0450	alkyl hydroperoxide reductase
GNK04_RS08075	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GNK04_RS08085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GNK04_RS08095	COG5609	conserved protein (DUF2294)
GNK04_RS08105	COG1597	lipid kinase activity
GNK04_RS08115	COG2112	serine threonine protein kinase
GNK04_RS08120	COG0628	permease
GNK04_RS08125	COG3584	3D domain protein
GNK04_RS08125	COG1388	LysM domain
GNK04_RS08145	COG0656	L-ascorbic acid biosynthetic process
GNK04_RS08150	COG4297	protein containing double-stranded beta helix domain
GNK04_RS08155	COG2190	(PTS) system
GNK04_RS08160	COG1263	PTS System
GNK04_RS08160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNK04_RS08165	COG0366	Alpha amylase catalytic
GNK04_RS08170	COG2188	Transcriptional regulator
GNK04_RS08180	COG2070	2-Nitropropane dioxygenase
GNK04_RS08200	COG1280	lysine exporter protein (LysE YggA)
GNK04_RS08210	COG1403	HNH endonuclease
GNK04_RS08215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNK04_RS08220	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS08225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GNK04_RS08230	COG0456	acetyltransferase
GNK04_RS08245	COG2404	hydrolase activity, acting on ester bonds
GNK04_RS08260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GNK04_RS08265	COG1136	(ABC) transporter
GNK04_RS08270	COG0577	efflux transmembrane transporter activity
GNK04_RS08275	COG0514	ATP-dependent DNA helicase (RecQ)
GNK04_RS08280	COG2323	membrane
GNK04_RS08300	COG0254	rRNA binding
GNK04_RS08310	COG1309	transcriptional regulator
GNK04_RS08315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GNK04_RS08320	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS08335	COG0681	Belongs to the peptidase S26 family
GNK04_RS08340	COG2340	Cysteine-rich secretory protein family
GNK04_RS08350	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS08355	COG3012	SEC-C Motif Domain Protein
GNK04_RS08355	COG1405	negative regulation of cell septum assembly
GNK04_RS08360	COG5002	protein histidine kinase activity
GNK04_RS08365	COG1316	TRANSCRIPTIONal
GNK04_RS08370	COG1295	ribonuclease BN
GNK04_RS08375	COG3852	Histidine kinase
GNK04_RS08395	COG2233	PERMEase
GNK04_RS08400	COG0589	response to stress
GNK04_RS08410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GNK04_RS08425	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GNK04_RS08435	COG2322	membrane
GNK04_RS08445	COG0702	epimerase
GNK04_RS08450	COG1473	amidohydrolase
GNK04_RS08465	COG5002	protein histidine kinase activity
GNK04_RS08475	COG0589	response to stress
GNK04_RS08480	COG0803	Belongs to the bacterial solute-binding protein 9 family
GNK04_RS08485	COG1121	(ABC) transporter
GNK04_RS08490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GNK04_RS08490	COG1321	iron dependent repressor
GNK04_RS08495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GNK04_RS08505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNK04_RS08510	COG0501	Belongs to the peptidase M48B family
GNK04_RS08525	COG2224	Isocitrate lyase
GNK04_RS08550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GNK04_RS08555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GNK04_RS08555	COG4499	WXG100 protein secretion system (Wss), protein YukC
GNK04_RS08615	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GNK04_RS08625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GNK04_RS08630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GNK04_RS08640	COG1368	sulfuric ester hydrolase activity
GNK04_RS08650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNK04_RS08655	COG0765	amino acid transport
GNK04_RS08665	COG1418	mRNA catabolic process
GNK04_RS08685	COG5002	protein histidine kinase activity
GNK04_RS08720	COG0398	Pfam SNARE associated Golgi protein
GNK04_RS08725	COG3546	catalase activity
GNK04_RS08750	COG1074	ATP-dependent DNA helicase activity
GNK04_RS08755	COG0420	3'-5' exonuclease activity
GNK04_RS08760	COG0419	ATPase involved in DNA repair
GNK04_RS08775	COG0179	Fumarylacetoacetate (FAA) hydrolase
GNK04_RS08780	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS08785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GNK04_RS08795	COG5001	Diguanylate cyclase
GNK04_RS08795	COG3300	MHYT domain
GNK04_RS08800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GNK04_RS08810	COG0367	asparagine synthase
GNK04_RS08815	COG0004	ammonium transporteR
GNK04_RS08820	COG0347	Belongs to the P(II) protein family
GNK04_RS08830	COG2182	Extracellular solute-binding protein
GNK04_RS08835	COG1175	transmembrane transport
GNK04_RS08840	COG3833	ABC-type maltose transport systems, permease component
GNK04_RS08845	COG1609	Transcriptional regulator
GNK04_RS08850	COG1793	dna ligase
GNK04_RS08850	COG3285	dna ligase
GNK04_RS08860	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GNK04_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS08870	COG5002	protein histidine kinase activity
GNK04_RS08875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GNK04_RS08885	COG1122	ATPase activity
GNK04_RS08900	COG1307	EDD domain protein, DegV family
GNK04_RS08905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNK04_RS08940	COG0561	phosphatase activity
GNK04_RS08950	COG1073	alpha beta
GNK04_RS08955	COG2151	metal-sulfur cluster biosynthetic enzyme
GNK04_RS08960	COG1388	LysM domain
GNK04_RS08960	COG3858	chitin binding
GNK04_RS08965	COG0303	'Molybdopterin
GNK04_RS08970	COG1763	Mo-molybdopterin cofactor biosynthetic process
GNK04_RS08975	COG0314	molybdopterin synthase activity
GNK04_RS08985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNK04_RS09010	COG2267	carboxylic ester hydrolase activity
GNK04_RS09015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GNK04_RS09050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GNK04_RS09055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GNK04_RS09065	COG0180	Tryptophanyl-tRNA synthetase
GNK04_RS09080	COG0601	transmembrane transport
GNK04_RS09085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GNK04_RS09090	COG0444	Belongs to the ABC transporter superfamily
GNK04_RS09095	COG4608	Belongs to the ABC transporter superfamily
GNK04_RS09110	COG1418	mRNA catabolic process
GNK04_RS09125	COG0456	acetyltransferase
GNK04_RS09140	COG1393	Belongs to the ArsC family
GNK04_RS09145	COG0861	Integral membrane protein TerC family
GNK04_RS09160	COG1164	Oligoendopeptidase f
GNK04_RS09175	COG2346	COG2346, Truncated hemoglobins
GNK04_RS09180	COG4116	CYTH
GNK04_RS09190	COG2357	RelA SpoT domain protein
GNK04_RS09195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GNK04_RS09200	COG0564	pseudouridine synthase activity
GNK04_RS09205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GNK04_RS09210	COG0772	Belongs to the SEDS family
GNK04_RS09215	COG2239	Acts as a magnesium transporter
GNK04_RS09220	COG0569	domain protein
GNK04_RS09220	COG0475	glutathione-regulated potassium exporter activity
GNK04_RS09225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GNK04_RS09255	COG0673	inositol 2-dehydrogenase activity
GNK04_RS09270	COG1388	LysM domain
GNK04_RS09270	COG4641	Protein conserved in bacteria
GNK04_RS09300	COG2323	membrane
GNK04_RS09305	COG2153	protein acetylation
GNK04_RS09310	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GNK04_RS09315	COG2382	esterase
GNK04_RS09320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GNK04_RS09340	COG2720	vancomycin resistance protein
GNK04_RS09345	COG5002	protein histidine kinase activity
GNK04_RS09365	COG0598	Magnesium transport protein CorA
GNK04_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS09375	COG0517	IMP dehydrogenase activity
GNK04_RS09380	COG0477	Major facilitator Superfamily
GNK04_RS09390	COG0730	response to heat
GNK04_RS09395	COG0583	DNA-binding transcription factor activity
GNK04_RS09400	COG2171	N-acyltransferase activity
GNK04_RS09405	COG1473	amidohydrolase
GNK04_RS09415	COG4572	Cation transport regulator
GNK04_RS09420	COG0668	transmembrane transport
GNK04_RS09425	COG0450	alkyl hydroperoxide reductase
GNK04_RS09430	COG1132	(ABC) transporter
GNK04_RS09435	COG1132	(ABC) transporter
GNK04_RS09440	COG1271	oxidase subunit
GNK04_RS09445	COG1294	oxidase, subunit
GNK04_RS09450	COG0569	domain protein
GNK04_RS09455	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GNK04_RS09465	COG0697	spore germination
GNK04_RS09470	COG0561	phosphatase activity
GNK04_RS09480	COG0497	DNA recombination
GNK04_RS09490	COG0022	dehydrogenase e1 component
GNK04_RS09495	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNK04_RS09505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNK04_RS09525	COG1982	Orn Lys Arg decarboxylase major
GNK04_RS09535	COG4476	Belongs to the UPF0223 family
GNK04_RS09540	COG4493	Belongs to the UPF0637 family
GNK04_RS09550	COG0483	inositol monophosphate 1-phosphatase activity
GNK04_RS09585	COG4896	Protein conserved in bacteria
GNK04_RS09600	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GNK04_RS09605	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GNK04_RS09610	COG2066	Belongs to the glutaminase family
GNK04_RS09615	COG4838	Belongs to the UPF0358 family
GNK04_RS09625	COG0772	Belongs to the SEDS family
GNK04_RS09630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GNK04_RS09650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GNK04_RS09660	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GNK04_RS09675	COG2340	Cysteine-rich secretory protein family
GNK04_RS09685	COG2340	Cysteine-rich secretory protein family
GNK04_RS09715	COG3679	Belongs to the UPF0342 family
GNK04_RS09725	COG4471	UPF0298 protein
GNK04_RS09745	COG0742	ribosomal rna small subunit methyltransferase
GNK04_RS09750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GNK04_RS09755	COG3314	Sporulation integral membrane protein YlbJ
GNK04_RS09760	COG1752	Esterase of the alpha-beta hydrolase superfamily
GNK04_RS09765	COG3480	Lon protease (S16) C-terminal proteolytic domain
GNK04_RS09770	COG1323	Belongs to the UPF0348 family
GNK04_RS09775	COG1399	metal-binding, possibly nucleic acid-binding protein
GNK04_RS09780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GNK04_RS09785	COG1024	Enoyl-CoA hydratase
GNK04_RS09795	COG0454	-acetyltransferase
GNK04_RS09800	COG0439	Biotin carboxylase
GNK04_RS09805	COG0511	ligase activity, forming carbon-carbon bonds
GNK04_RS09810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GNK04_RS09815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GNK04_RS09830	COG2001	Belongs to the MraZ family
GNK04_RS09850	COG0768	penicillin binding
GNK04_RS09860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GNK04_RS09865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GNK04_RS09870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GNK04_RS09875	COG0772	Belongs to the SEDS family
GNK04_RS09880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GNK04_RS09885	COG0849	cell division
GNK04_RS09890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GNK04_RS09895	COG0460	homoserine dehydrogenase
GNK04_RS09900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GNK04_RS09905	COG0083	homoserine kinase activity
GNK04_RS09915	COG1191	sigma factor activity
GNK04_RS09920	COG1191	sigma factor activity
GNK04_RS09925	COG1873	PFAM PRC-barrel domain
GNK04_RS09935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GNK04_RS09940	COG1799	cell septum assembly
GNK04_RS09950	COG2302	S4 RNA-binding domain
GNK04_RS09955	COG3599	regulation of cell shape
GNK04_RS09960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GNK04_RS09965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GNK04_RS09970	COG0564	pseudouridine synthase activity
GNK04_RS09975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GNK04_RS09985	COG0540	Belongs to the ATCase OTCase family
GNK04_RS09990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GNK04_RS10000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GNK04_RS10010	COG0167	dihydroorotate dehydrogenase activity
GNK04_RS10015	COG0284	orotidine-5'-phosphate decarboxylase activity
GNK04_RS10025	COG2226	methyltransferase
GNK04_RS10035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GNK04_RS10040	COG1561	YicC-like family, N-terminal region
GNK04_RS10045	COG2052	Domain of unknown function (DUF370)
GNK04_RS10050	COG0194	GDP metabolic process
GNK04_RS10060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GNK04_RS10065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GNK04_RS10075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GNK04_RS10080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GNK04_RS10080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GNK04_RS10095	COG1162	GTPase activity
GNK04_RS10100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GNK04_RS10105	COG3859	Proton-coupled thiamine transporter YuaJ
GNK04_RS10110	COG1564	THIamine pyrophosphokinase
GNK04_RS10120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GNK04_RS10125	COG1302	Protein conserved in bacteria
GNK04_RS10130	COG1461	Dihydroxyacetone kinase
GNK04_RS10135	COG1760	l-serine dehydratase
GNK04_RS10140	COG1760	l-serine dehydratase
GNK04_RS10145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GNK04_RS10150	COG1349	DNA-binding transcription factor activity
GNK04_RS10160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GNK04_RS10165	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS10170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNK04_RS10185	COG1196	nuclear chromosome segregation
GNK04_RS10190	COG0552	protein localization to endoplasmic reticulum
GNK04_RS10195	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GNK04_RS10200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GNK04_RS10205	COG0228	four-way junction DNA binding
GNK04_RS10210	COG1837	Belongs to the UPF0109 family
GNK04_RS10245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GNK04_RS10255	COG0045	succinate-CoA ligase (ADP-forming) activity
GNK04_RS10260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GNK04_RS10265	COG0758	DNA mediated transformation
GNK04_RS10270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GNK04_RS10275	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GNK04_RS10280	COG4974	Belongs to the 'phage' integrase family
GNK04_RS10285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GNK04_RS10290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GNK04_RS10295	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GNK04_RS10300	COG0052	Belongs to the universal ribosomal protein uS2 family
GNK04_RS10305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GNK04_RS10310	COG0528	UMP kinase activity
GNK04_RS10315	COG0233	cytoplasmic translational termination
GNK04_RS10320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GNK04_RS10325	COG4589	Belongs to the CDS family
GNK04_RS10335	COG0750	zinc metalloprotease
GNK04_RS10345	COG2176	DNA-directed DNA polymerase activity
GNK04_RS10355	COG0195	Participates in both transcription termination and antitermination
GNK04_RS10360	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GNK04_RS10365	COG1358	cellular component organization or biogenesis
GNK04_RS10370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GNK04_RS10375	COG1550	Protein conserved in bacteria
GNK04_RS10380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GNK04_RS10385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GNK04_RS10390	COG0196	riboflavin kinase activity
GNK04_RS10395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GNK04_RS10400	COG1185	polyribonucleotide nucleotidyltransferase activity
GNK04_RS10405	COG0726	polysaccharide deacetylase
GNK04_RS10410	COG0612	Peptidase, M16
GNK04_RS10415	COG1873	PFAM PRC-barrel domain
GNK04_RS10420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GNK04_RS10425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GNK04_RS10430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GNK04_RS10435	COG0527	aspartate kinase activity
GNK04_RS10445	COG0740	serine-type endopeptidase activity
GNK04_RS10455	COG1674	ftsk spoiiie
GNK04_RS10455	COG4980	gas vesicle protein
GNK04_RS10480	COG0612	Peptidase, M16
GNK04_RS10485	COG0612	Peptidase, M16
GNK04_RS10490	COG0300	oxidoreductase activity
GNK04_RS10505	COG1426	Protein conserved in bacteria
GNK04_RS10510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GNK04_RS10515	COG1546	Belongs to the CinA family
GNK04_RS10515	COG1058	Belongs to the CinA family
GNK04_RS10520	COG0513	Belongs to the DEAD box helicase family
GNK04_RS10525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GNK04_RS10535	COG1692	metallophosphoesterase
GNK04_RS10540	COG2359	stage V sporulation protein S
GNK04_RS10550	COG0674	pyruvate-flavodoxin oxidoreductase activity
GNK04_RS10550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GNK04_RS10555	COG1013	pyruvate-flavodoxin oxidoreductase activity
GNK04_RS10560	COG1063	alcohol dehydrogenase
GNK04_RS10565	COG0156	8-amino-7-oxononanoate synthase activity
GNK04_RS10570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GNK04_RS10575	COG4550	Control of competence regulator ComK, YlbF/YmcA
GNK04_RS10600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GNK04_RS10630	COG0464	growth
GNK04_RS10635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GNK04_RS10640	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GNK04_RS10645	COG0174	glutamine synthetase
GNK04_RS10650	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS10665	COG0446	pyridine nucleotide-disulphide oxidoreductase
GNK04_RS10670	COG0791	NLP P60 protein
GNK04_RS10670	COG1388	LysM domain
GNK04_RS10675	COG1051	belongs to the nudix hydrolase family
GNK04_RS10680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GNK04_RS10690	COG3250	beta-galactosidase activity
GNK04_RS10695	COG2211	Major facilitator Superfamily
GNK04_RS10710	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS10720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GNK04_RS10725	COG1388	LysM domain
GNK04_RS10730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GNK04_RS10735	COG4224	UPF0291 protein
GNK04_RS10750	COG3763	UPF0154 protein
GNK04_RS10755	COG1876	peptidase activity
GNK04_RS10760	COG0785	Cytochrome C biogenesis protein
GNK04_RS10765	COG2111	Na H antiporter
GNK04_RS10770	COG4846	Membrane protein involved in cytochrome C biogenesis
GNK04_RS10800	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GNK04_RS10815	COG1921	L-seryl-tRNASec selenium transferase activity
GNK04_RS10835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GNK04_RS10865	COG0824	Thioesterase
GNK04_RS10875	COG4841	protein insertion into membrane
GNK04_RS10880	COG2755	lipolytic protein G-D-S-L family
GNK04_RS10885	COG2755	lipolytic protein G-D-S-L family
GNK04_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS10920	COG0513	Belongs to the DEAD box helicase family
GNK04_RS10925	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GNK04_RS10935	COG0436	Aminotransferase
GNK04_RS10940	COG2508	Transcriptional regulator
GNK04_RS10940	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GNK04_RS10945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GNK04_RS10950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GNK04_RS10955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GNK04_RS10960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GNK04_RS10965	COG0456	acetyltransferase
GNK04_RS10970	COG3829	transcription factor binding
GNK04_RS10975	COG1509	lysine 2,3-aminomutase activity
GNK04_RS10990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GNK04_RS10995	COG0328	RNA-DNA hybrid ribonuclease activity
GNK04_RS11005	COG0328	RNA-DNA hybrid ribonuclease activity
GNK04_RS11015	COG1278	Cold shock
GNK04_RS11025	COG1607	acyl-coa hydrolase
GNK04_RS11035	COG2996	Protein conserved in bacteria
GNK04_RS11050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GNK04_RS11055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GNK04_RS11060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GNK04_RS11065	COG0297	glycogen (starch) synthase activity
GNK04_RS11070	COG2200	EAL domain
GNK04_RS11085	COG1413	lyase activity
GNK04_RS11120	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS11125	COG3773	Cell wall hydrolase
GNK04_RS11125	COG3409	Peptidoglycan-binding domain 1 protein
GNK04_RS11205	COG4844	belongs to the
GNK04_RS11220	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GNK04_RS11225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GNK04_RS11230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNK04_RS11250	COG0488	(ABC) transporter
GNK04_RS11255	COG2362	D-Aminopeptidase
GNK04_RS11260	COG0601	transmembrane transport
GNK04_RS11265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GNK04_RS11270	COG4166	transmembrane transport
GNK04_RS11275	COG4948	Mandelate Racemase Muconate Lactonizing
GNK04_RS11280	COG0791	NLP P60 protein
GNK04_RS11290	COG1376	ErfK ybiS ycfS ynhG family protein
GNK04_RS11310	COG1562	ergosterol biosynthetic process
GNK04_RS11325	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GNK04_RS11330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNK04_RS11340	COG3655	Transcriptional regulator
GNK04_RS11345	COG3739	integral membrane protein
GNK04_RS11365	COG3340	Belongs to the peptidase S51 family
GNK04_RS11375	COG1215	transferase activity, transferring glycosyl groups
GNK04_RS11395	COG1304	FMN binding
GNK04_RS11400	COG1757	Na H antiporter
GNK04_RS11405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GNK04_RS11415	COG4988	ABC transporter
GNK04_RS11420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GNK04_RS11445	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GNK04_RS11450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GNK04_RS11455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GNK04_RS11460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GNK04_RS11465	COG0505	Belongs to the CarA family
GNK04_RS11470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GNK04_RS11475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GNK04_RS11480	COG0137	argininosuccinate synthase activity
GNK04_RS11485	COG0165	Argininosuccinate lyase
GNK04_RS11495	COG4667	esterase of the alpha-beta hydrolase superfamily
GNK04_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS11525	COG2755	lipolytic protein G-D-S-L family
GNK04_RS11530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GNK04_RS11535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNK04_RS11550	COG0423	glycine-tRNA ligase activity
GNK04_RS11560	COG2814	Major facilitator Superfamily
GNK04_RS11565	COG0583	DNA-binding transcription factor activity
GNK04_RS11570	COG0067	glutamate synthase
GNK04_RS11570	COG0069	glutamate synthase activity
GNK04_RS11570	COG0070	glutamate synthase
GNK04_RS11575	COG0493	'glutamate synthase
GNK04_RS11580	COG0346	lactoylglutathione lyase activity
GNK04_RS11585	COG0400	carboxylic ester hydrolase activity
GNK04_RS11590	COG1301	dicarboxylic acid transport
GNK04_RS11595	COG2521	methyltransferase
GNK04_RS11595	COG2136	Putative SAM-dependent methyltransferase
GNK04_RS11610	COG4548	von Willebrand factor, type A
GNK04_RS11615	COG0714	Associated with various cellular activities
GNK04_RS11620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GNK04_RS11630	COG0488	(ABC) transporter
GNK04_RS11635	COG0534	Mate efflux family protein
GNK04_RS11640	COG3011	Protein conserved in bacteria
GNK04_RS11645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GNK04_RS11655	COG0493	'glutamate synthase
GNK04_RS11690	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS11695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GNK04_RS11705	COG0567	Dehydrogenase, E1 component
GNK04_RS11710	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNK04_RS11720	COG2391	methyltransferase activity
GNK04_RS11725	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GNK04_RS11730	COG2329	Antibiotic biosynthesis monooxygenase
GNK04_RS11750	COG0656	L-ascorbic acid biosynthetic process
GNK04_RS11765	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS11775	COG2027	D-alanyl-D-alanine carboxypeptidase
GNK04_RS11790	COG0583	DNA-binding transcription factor activity
GNK04_RS11800	COG0346	lactoylglutathione lyase activity
GNK04_RS11805	COG2814	Major facilitator Superfamily
GNK04_RS11815	COG0737	Belongs to the 5'-nucleotidase family
GNK04_RS11830	COG0582	viral genome integration into host DNA
GNK04_RS11840	COG0371	Dehydrogenase
GNK04_RS11850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GNK04_RS11860	COG1199	ATP-dependent helicase activity
GNK04_RS11870	COG0406	alpha-ribazole phosphatase activity
GNK04_RS11880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GNK04_RS11885	COG0569	domain protein
GNK04_RS11890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GNK04_RS11895	COG2340	Cysteine-rich secretory protein family
GNK04_RS11900	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS11915	COG2268	Band 7 protein
GNK04_RS11920	COG0277	FAD linked oxidase domain protein
GNK04_RS11925	COG3290	protein histidine kinase activity
GNK04_RS11925	COG3829	transcription factor binding
GNK04_RS11935	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS11950	COG0318	PFAM AMP-dependent synthetase and ligase
GNK04_RS11955	COG1250	3-hydroxyacyl-CoA dehydrogenase
GNK04_RS11960	COG1024	Enoyl-CoA hydratase
GNK04_RS11970	COG1250	3-hydroxyacyl-CoA dehydrogenase
GNK04_RS11975	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS12000	COG0076	glutamate decarboxylase activity
GNK04_RS12035	COG0667	Aldo Keto reductase
GNK04_RS12050	COG0583	DNA-binding transcription factor activity
GNK04_RS12055	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GNK04_RS12060	COG2186	Transcriptional regulator
GNK04_RS12065	COG0277	FAD linked oxidase domain protein
GNK04_RS12070	COG0247	lactate metabolic process
GNK04_RS12075	COG0277	FAD linked oxidase domain protein
GNK04_RS12080	COG0179	Fumarylacetoacetate (FAA) hydrolase
GNK04_RS12085	COG1620	l-lactate permease
GNK04_RS12090	COG2233	PERMEase
GNK04_RS12095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GNK04_RS12100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNK04_RS12110	COG1620	l-lactate permease
GNK04_RS12125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GNK04_RS12145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GNK04_RS12150	COG1388	LysM domain
GNK04_RS12165	COG5002	protein histidine kinase activity
GNK04_RS12170	COG0745	RESPONSE REGULATOR receiver
GNK04_RS12190	COG0346	lactoylglutathione lyase activity
GNK04_RS12205	COG1473	amidohydrolase
GNK04_RS12215	COG4948	Mandelate Racemase Muconate Lactonizing
GNK04_RS12235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GNK04_RS12245	COG0398	Pfam SNARE associated Golgi protein
GNK04_RS12250	COG1988	membrane-bound metal-dependent
GNK04_RS12255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GNK04_RS12260	COG0187	DNA topoisomerase II activity
GNK04_RS12270	COG1268	BioY protein
GNK04_RS12290	COG2124	cytochrome p450
GNK04_RS12305	COG1832	CoA-binding protein
GNK04_RS12315	COG2814	Major facilitator Superfamily
GNK04_RS12320	COG1278	Cold shock
GNK04_RS12330	COG0456	acetyltransferase
GNK04_RS12350	COG0604	alcohol dehydrogenase
GNK04_RS12370	COG0318	PFAM AMP-dependent synthetase and ligase
GNK04_RS12385	COG0410	ABC transporter
GNK04_RS12390	COG0411	ABC transporter
GNK04_RS12400	COG0559	Belongs to the binding-protein-dependent transport system permease family
GNK04_RS12405	COG1024	Enoyl-CoA hydratase
GNK04_RS12415	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS12420	COG2045	Belongs to the ComB family
GNK04_RS12435	COG1024	Enoyl-CoA hydratase
GNK04_RS12440	COG1250	3-hydroxyacyl-CoA dehydrogenase
GNK04_RS12445	COG1309	transcriptional regulator
GNK04_RS12450	COG0318	PFAM AMP-dependent synthetase and ligase
GNK04_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS12470	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS12475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GNK04_RS12480	COG0318	PFAM AMP-dependent synthetase and ligase
GNK04_RS12490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GNK04_RS12510	COG0116	Belongs to the methyltransferase superfamily
GNK04_RS12520	COG3599	regulation of cell shape
GNK04_RS12525	COG4474	Belongs to the UPF0398 family
GNK04_RS12545	COG3359	exonuclease
GNK04_RS12550	COG1111	helicase
GNK04_RS12550	COG1205	dead DEAH box helicase
GNK04_RS12560	COG1331	Highly conserved protein containing a thioredoxin domain
GNK04_RS12575	COG2986	histidine ammonia-lyase
GNK04_RS12585	COG0010	Belongs to the arginase family
GNK04_RS12590	COG1228	amidohydrolase
GNK04_RS12595	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GNK04_RS12600	COG3588	fructose-bisphosphate aldolase
GNK04_RS12605	COG2207	Transcriptional regulator
GNK04_RS12625	COG2366	antibiotic biosynthetic process
GNK04_RS12630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GNK04_RS12645	COG1595	DNA-templated transcription, initiation
GNK04_RS12655	COG1131	(ABC) transporter
GNK04_RS12660	COG1725	Transcriptional regulator
GNK04_RS12675	COG1252	NADH dehydrogenase
GNK04_RS12680	COG1621	beta-fructofuranosidase activity
GNK04_RS12685	COG2133	pyrroloquinoline quinone binding
GNK04_RS12695	COG3773	Cell wall hydrolase
GNK04_RS12700	COG2226	methyltransferase
GNK04_RS12725	COG0456	acetyltransferase
GNK04_RS12785	COG0693	protein deglycase activity
GNK04_RS12810	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS12815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GNK04_RS12825	COG2860	membrane
GNK04_RS12830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GNK04_RS12905	COG0582	viral genome integration into host DNA
GNK04_RS12935	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GNK04_RS12940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GNK04_RS12980	COG3844	kynureninase activity
GNK04_RS12995	COG1115	amino acid carrier protein
GNK04_RS13005	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
GNK04_RS13015	COG1686	Belongs to the peptidase S11 family
GNK04_RS13045	COG0789	Transcriptional regulator
GNK04_RS13055	COG3331	DNA recombination
GNK04_RS13060	COG4499	WXG100 protein secretion system (Wss), protein YukC
GNK04_RS13060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GNK04_RS13065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GNK04_RS13070	COG3935	DnaD domain protein
GNK04_RS13075	COG0017	Asparaginyl-tRNA synthetase
GNK04_RS13080	COG0436	Aminotransferase
GNK04_RS13100	COG1199	ATP-dependent helicase activity
GNK04_RS13100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GNK04_RS13105	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GNK04_RS13110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GNK04_RS13130	COG0438	transferase activity, transferring glycosyl groups
GNK04_RS13135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GNK04_RS13140	COG1803	Methylglyoxal synthase
GNK04_RS13145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GNK04_RS13150	COG1694	Mazg nucleotide pyrophosphohydrolase
GNK04_RS13155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNK04_RS13160	COG2738	Putative neutral zinc metallopeptidase
GNK04_RS13170	COG4347	Protein of unknown function (DUF1405)
GNK04_RS13180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GNK04_RS13200	COG5582	Belongs to the UPF0302 family
GNK04_RS13205	COG0457	Tetratricopeptide repeat
GNK04_RS13210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GNK04_RS13215	COG0287	Prephenate dehydrogenase
GNK04_RS13220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GNK04_RS13225	COG0159	tryptophan synthase activity
GNK04_RS13230	COG0133	tryptophan synthase activity
GNK04_RS13235	COG0135	phosphoribosylanthranilate isomerase activity
GNK04_RS13240	COG0134	indole-3-glycerol-phosphate synthase activity
GNK04_RS13245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GNK04_RS13255	COG4401	Chorismate mutase type I
GNK04_RS13260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GNK04_RS13265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GNK04_RS13275	COG0105	UTP biosynthetic process
GNK04_RS13280	COG0142	geranyltranstransferase activity
GNK04_RS13285	COG2226	methyltransferase
GNK04_RS13290	COG0142	geranyltranstransferase activity
GNK04_RS13300	COG0302	gtp cyclohydrolase
GNK04_RS13305	COG0776	regulation of translation
GNK04_RS13310	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GNK04_RS13335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GNK04_RS13340	COG1160	GTP binding
GNK04_RS13365	COG0539	negative regulation of cytoplasmic translation
GNK04_RS13370	COG0204	Acyl-transferase
GNK04_RS13375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GNK04_RS13385	COG2959	enzyme of heme biosynthesis
GNK04_RS13390	COG3409	Peptidoglycan-binding domain 1 protein
GNK04_RS13390	COG3773	Cell wall hydrolase
GNK04_RS13395	COG2339	peptidase activity
GNK04_RS13400	COG0252	asparaginase activity
GNK04_RS13405	COG0492	ferredoxin-NADP+ reductase activity
GNK04_RS13410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GNK04_RS13415	COG1181	Belongs to the D-alanine--D-alanine ligase family
GNK04_RS13420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GNK04_RS13425	COG4862	establishment of competence for transformation
GNK04_RS13435	COG1408	metallophosphoesterase
GNK04_RS13465	COG0514	ATP-dependent DNA helicase (RecQ)
GNK04_RS13470	COG4955	Helix-turn-helix domain
GNK04_RS13475	COG1141	Ferredoxin
GNK04_RS13480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GNK04_RS13485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GNK04_RS13490	COG5002	protein histidine kinase activity
GNK04_RS13495	COG0745	RESPONSE REGULATOR receiver
GNK04_RS13500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GNK04_RS13505	COG1333	cytochrome c biogenesis protein
GNK04_RS13510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNK04_RS13515	COG1187	pseudouridine synthase activity
GNK04_RS13520	COG0700	Nucleoside recognition
GNK04_RS13525	COG2715	membrane protein required for spore maturation
GNK04_RS13530	COG1686	Belongs to the peptidase S11 family
GNK04_RS13535	COG1755	Isoprenylcysteine carboxyl methyltransferase
GNK04_RS13540	COG3424	synthase
GNK04_RS13550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GNK04_RS13560	COG1547	Domain of unknown function (DUF309)
GNK04_RS13570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GNK04_RS13575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GNK04_RS13575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GNK04_RS13580	COG0307	riboflavin synthase, alpha
GNK04_RS13585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GNK04_RS13585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GNK04_RS13590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GNK04_RS13595	COG0019	diaminopimelate decarboxylase activity
GNK04_RS13600	COG0697	spore germination
GNK04_RS13615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GNK04_RS13635	COG1191	sigma factor activity
GNK04_RS13645	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS13650	COG1686	Belongs to the peptidase S11 family
GNK04_RS13670	COG4974	Belongs to the 'phage' integrase family
GNK04_RS13680	COG0735	belongs to the Fur family
GNK04_RS13685	COG1300	Membrane
GNK04_RS13690	COG1379	DNA repair
GNK04_RS13695	COG0494	nUDIX hydrolase
GNK04_RS13710	COG0667	Aldo Keto reductase
GNK04_RS13715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GNK04_RS13720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GNK04_RS13730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GNK04_RS13750	COG1404	Belongs to the peptidase S8 family
GNK04_RS13750	COG4412	M6 family metalloprotease domain protein
GNK04_RS13770	COG0398	Pfam SNARE associated Golgi protein
GNK04_RS13775	COG3842	ATPase activity
GNK04_RS13780	COG1175	transmembrane transport
GNK04_RS13790	COG4134	Bacterial extracellular solute-binding protein
GNK04_RS13800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GNK04_RS13820	COG1280	lysine exporter protein (LysE YggA)
GNK04_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS13835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GNK04_RS13840	COG1845	cytochrome c oxidase, subunit III
GNK04_RS13860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNK04_RS13870	COG1595	DNA-templated transcription, initiation
GNK04_RS13875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNK04_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS13885	COG4589	Belongs to the CDS family
GNK04_RS13895	COG1227	inorganic diphosphatase activity
GNK04_RS13900	COG0702	epimerase
GNK04_RS13905	COG2814	Major facilitator Superfamily
GNK04_RS13910	COG1378	Sugar-specific transcriptional regulator TrmB
GNK04_RS13915	COG2002	toxin-antitoxin pair type II binding
GNK04_RS13920	COG1846	Transcriptional regulator
GNK04_RS13925	COG2409	Drug exporters of the RND superfamily
GNK04_RS13925	COG1033	growth of symbiont in host cell
GNK04_RS13945	COG1876	peptidase activity
GNK04_RS13960	COG0561	phosphatase activity
GNK04_RS13990	COG2814	Major facilitator Superfamily
GNK04_RS13995	COG0471	metal ion transport
GNK04_RS14010	COG2267	carboxylic ester hydrolase activity
GNK04_RS14020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GNK04_RS14035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNK04_RS14040	COG3152	Membrane
GNK04_RS14070	COG0300	oxidoreductase activity
GNK04_RS14075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNK04_RS14080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GNK04_RS14090	COG0789	Transcriptional regulator
GNK04_RS14105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNK04_RS14110	COG0733	neurotransmitter:sodium symporter activity
GNK04_RS14115	COG0768	penicillin binding
GNK04_RS14120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GNK04_RS14125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GNK04_RS14140	COG4187	Peptidase family M20/M25/M40
GNK04_RS14145	COG0584	glycerophosphoryl diester phosphodiesterase
GNK04_RS14150	COG1902	pentaerythritol trinitrate reductase activity
GNK04_RS14155	COG1234	tRNA 3'-trailer cleavage
GNK04_RS14175	COG0714	Associated with various cellular activities
GNK04_RS14180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GNK04_RS14190	COG2195	Cleaves the N-terminal amino acid of tripeptides
GNK04_RS14195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GNK04_RS14200	COG0346	lactoylglutathione lyase activity
GNK04_RS14205	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GNK04_RS14205	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GNK04_RS14215	COG1376	ErfK ybiS ycfS ynhG family protein
GNK04_RS14220	COG4129	membrane
GNK04_RS14225	COG1126	abc transporter atp-binding protein
GNK04_RS14230	COG0765	amino acid transport
GNK04_RS14235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNK04_RS14245	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNK04_RS14250	COG0022	dehydrogenase e1 component
GNK04_RS14255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GNK04_RS14260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GNK04_RS14275	COG0280	phosphate acetyltransferase
GNK04_RS14280	COG3829	transcription factor binding
GNK04_RS14280	COG3290	protein histidine kinase activity
GNK04_RS14290	COG0745	RESPONSE REGULATOR receiver
GNK04_RS14295	COG0750	zinc metalloprotease
GNK04_RS14300	COG0497	DNA recombination
GNK04_RS14305	COG1438	arginine binding
GNK04_RS14310	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GNK04_RS14315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GNK04_RS14325	COG0142	geranyltranstransferase activity
GNK04_RS14330	COG1722	exodeoxyribonuclease VII activity
GNK04_RS14335	COG1570	exodeoxyribonuclease VII activity
GNK04_RS14340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GNK04_RS14345	COG1302	Protein conserved in bacteria
GNK04_RS14350	COG0439	Biotin carboxylase
GNK04_RS14355	COG0511	ligase activity, forming carbon-carbon bonds
GNK04_RS14395	COG3854	ATPases associated with a variety of cellular activities
GNK04_RS14415	COG1131	(ABC) transporter
GNK04_RS14420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GNK04_RS14425	COG0006	proline dipeptidase activity
GNK04_RS14430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GNK04_RS14440	COG3872	metal-dependent enzyme
GNK04_RS14450	COG1752	Esterase of the alpha-beta hydrolase superfamily
GNK04_RS14455	COG1321	iron dependent repressor
GNK04_RS14460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GNK04_RS14465	COG0095	Lipoate-protein ligase
GNK04_RS14470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNK04_RS14475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GNK04_RS14480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GNK04_RS14485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GNK04_RS14490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GNK04_RS14530	COG4537	Required for transformation and DNA binding
GNK04_RS14540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GNK04_RS14565	COG1393	Belongs to the ArsC family
GNK04_RS14580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNK04_RS14595	COG0011	TIGRFAM Protein of
GNK04_RS14600	COG0390	transport system, permease component
GNK04_RS14605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GNK04_RS14610	COG0351	phosphomethylpyrimidine kinase
GNK04_RS14615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GNK04_RS14620	COG2022	thiamine diphosphate biosynthetic process
GNK04_RS14630	COG0352	thiamine-phosphate diphosphorylase activity
GNK04_RS14645	COG1368	sulfuric ester hydrolase activity
GNK04_RS14650	COG1940	carbohydrate kinase activity
GNK04_RS14655	COG0778	Nitroreductase
GNK04_RS14660	COG4483	Protein conserved in bacteria
GNK04_RS14665	COG0697	spore germination
GNK04_RS14670	COG1363	Peptidase, m42
GNK04_RS14680	COG1011	Hydrolase
GNK04_RS14690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GNK04_RS14705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GNK04_RS14710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GNK04_RS14720	COG0704	Plays a role in the regulation of phosphate uptake
GNK04_RS14725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GNK04_RS14730	COG0581	inorganic phosphate transmembrane transporter activity
GNK04_RS14735	COG0573	inorganic phosphate transmembrane transporter activity
GNK04_RS14740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GNK04_RS14750	COG0477	Major facilitator Superfamily
GNK04_RS14800	COG2839	Protein conserved in bacteria
GNK04_RS14810	COG5521	maltodextrose utilization protein MalA
GNK04_RS14815	COG0626	cystathionine gamma-synthase activity
GNK04_RS14820	COG0626	cystathionine gamma-synthase activity
GNK04_RS14825	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GNK04_RS14825	COG0646	methionine synthase
GNK04_RS14830	COG1410	methionine synthase
GNK04_RS14830	COG0646	methionine synthase
GNK04_RS14850	COG0529	Catalyzes the synthesis of activated sulfate
GNK04_RS14855	COG2046	Belongs to the sulfate adenylyltransferase family
GNK04_RS14860	COG0306	phosphate transporter
GNK04_RS14865	COG0175	sulfate reduction
GNK04_RS14890	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GNK04_RS14895	COG4709	membrane
GNK04_RS14900	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GNK04_RS14905	COG0735	belongs to the Fur family
GNK04_RS14910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GNK04_RS14915	COG1121	(ABC) transporter
GNK04_RS14925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNK04_RS14935	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GNK04_RS14940	COG0513	Belongs to the DEAD box helicase family
GNK04_RS14950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GNK04_RS14955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GNK04_RS14960	COG2384	SAM-dependent methyltransferase
GNK04_RS14970	COG0318	PFAM AMP-dependent synthetase and ligase
GNK04_RS14975	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS14980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GNK04_RS14985	COG0358	DNA primase activity
GNK04_RS14990	COG1671	Belongs to the UPF0178 family
GNK04_RS14995	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GNK04_RS15000	COG0517	IMP dehydrogenase activity
GNK04_RS15005	COG1381	Involved in DNA repair and RecF pathway recombination
GNK04_RS15015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GNK04_RS15020	COG0295	cytidine deaminase activity
GNK04_RS15025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GNK04_RS15030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GNK04_RS15035	COG1480	7TM receptor with intracellular HD hydrolase
GNK04_RS15040	COG1702	phosphate starvation-inducible protein PhoH
GNK04_RS15060	COG4864	UPF0365 protein
GNK04_RS15065	COG1030	water channel activity
GNK04_RS15070	COG1610	YqeY-like protein
GNK04_RS15075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GNK04_RS15080	COG1283	sodium-dependent phosphate transmembrane transporter activity
GNK04_RS15085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GNK04_RS15090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GNK04_RS15095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GNK04_RS15100	COG2264	protein methyltransferase activity
GNK04_RS15110	COG0443	Heat shock 70 kDa protein
GNK04_RS15115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GNK04_RS15120	COG1420	regulation of RNA biosynthetic process
GNK04_RS15125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GNK04_RS15130	COG0481	GTPase activity
GNK04_RS15145	COG0268	Binds directly to 16S ribosomal RNA
GNK04_RS15150	COG1466	dna polymerase III delta subunit
GNK04_RS15160	COG0658	competence protein
GNK04_RS15160	COG2333	competence protein COMEC
GNK04_RS15165	COG2131	deaminase
GNK04_RS15170	COG1596	polysaccharide export
GNK04_RS15170	COG1555	photosystem II stabilization
GNK04_RS15175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GNK04_RS15180	COG2226	methyltransferase
GNK04_RS15185	COG0799	negative regulation of ribosome biogenesis
GNK04_RS15190	COG1713	HD superfamily hydrolase involved in NAD metabolism
GNK04_RS15195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GNK04_RS15200	COG1534	Rna-binding protein
GNK04_RS15205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GNK04_RS15210	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GNK04_RS15215	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GNK04_RS15230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GNK04_RS15230	COG2111	Na H antiporter
GNK04_RS15235	COG1006	Multisubunit Na H antiporter MnhC subunit
GNK04_RS15240	COG0651	ATP synthesis coupled electron transport
GNK04_RS15250	COG2212	antiporter activity
GNK04_RS15260	COG0535	radical SAM domain protein
GNK04_RS15270	COG1191	sigma factor activity
GNK04_RS15280	COG1959	2 iron, 2 sulfur cluster binding
GNK04_RS15300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GNK04_RS15330	COG0626	cystathionine gamma-synthase activity
GNK04_RS15335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GNK04_RS15340	COG1854	S-ribosylhomocysteine lyase activity
GNK04_RS15345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GNK04_RS15350	COG2226	methyltransferase
GNK04_RS15365	COG0768	penicillin binding
GNK04_RS15370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GNK04_RS15375	COG0572	uridine kinase
GNK04_RS15385	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GNK04_RS15390	COG3906	Belongs to the UPF0473 family
GNK04_RS15400	COG4472	Bacterial protein of unknown function (DUF965)
GNK04_RS15410	COG0628	permease
GNK04_RS15420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GNK04_RS15430	COG0482	sulfurtransferase activity
GNK04_RS15435	COG1104	cysteine desulfurase activity
GNK04_RS15440	COG1959	2 iron, 2 sulfur cluster binding
GNK04_RS15445	COG2364	Membrane
GNK04_RS15450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GNK04_RS15470	COG0124	histidyl-tRNA synthetase
GNK04_RS15480	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS15480	COG4991	sh3 domain protein
GNK04_RS15480	COG3103	Sh3 type 3 domain protein
GNK04_RS15485	COG1490	D-aminoacyl-tRNA deacylase activity
GNK04_RS15490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GNK04_RS15495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GNK04_RS15500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GNK04_RS15500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GNK04_RS15505	COG5416	Lipopolysaccharide assembly protein A domain
GNK04_RS15510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GNK04_RS15530	COG2244	polysaccharide biosynthetic process
GNK04_RS15535	COG2323	membrane
GNK04_RS15540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GNK04_RS15550	COG1862	Preprotein translocase
GNK04_RS15555	COG0343	queuine tRNA-ribosyltransferase activity
GNK04_RS15560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GNK04_RS15585	COG0217	transcriptional regulatory protein
GNK04_RS15605	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GNK04_RS15610	COG0157	Belongs to the NadC ModD family
GNK04_RS15615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GNK04_RS15620	COG1104	cysteine desulfurase activity
GNK04_RS15625	COG1827	regulation of RNA biosynthetic process
GNK04_RS15630	COG0077	Prephenate dehydratase
GNK04_RS15635	COG4492	Belongs to the UPF0735 family
GNK04_RS15640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GNK04_RS15645	COG3290	protein histidine kinase activity
GNK04_RS15650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GNK04_RS15655	COG2868	ribosomal protein
GNK04_RS15660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GNK04_RS15665	COG1530	ribonuclease E activity
GNK04_RS15670	COG1994	Peptidase M50
GNK04_RS15680	COG2894	cell division
GNK04_RS15685	COG0850	regulation of cytokinetic process
GNK04_RS15690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GNK04_RS15695	COG1792	Involved in formation and maintenance of cell shape
GNK04_RS15700	COG1077	Cell shape determining protein MreB Mrl
GNK04_RS15705	COG2003	Belongs to the UPF0758 family
GNK04_RS15720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GNK04_RS15725	COG3706	GGDEF domain
GNK04_RS15730	COG0285	dihydrofolate synthase activity
GNK04_RS15735	COG0525	valine-tRNA ligase activity
GNK04_RS15755	COG1388	LysM domain
GNK04_RS15755	COG1388	LysM domain
GNK04_RS15760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GNK04_RS15765	COG0113	porphobilinogen synthase activity
GNK04_RS15775	COG0181	hydroxymethylbilane synthase activity
GNK04_RS15780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GNK04_RS15785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GNK04_RS15795	COG1126	abc transporter atp-binding protein
GNK04_RS15800	COG0765	amino acid transport
GNK04_RS15805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNK04_RS15810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GNK04_RS15815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GNK04_RS15820	COG1067	ATP-dependent peptidase activity
GNK04_RS15820	COG0470	DNA polymerase III
GNK04_RS15825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GNK04_RS15830	COG0544	peptidyl-prolyl cis-trans isomerase activity
GNK04_RS15835	COG1477	protein flavinylation
GNK04_RS15835	COG0457	Tetratricopeptide repeat
GNK04_RS15850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GNK04_RS15855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GNK04_RS15860	COG5401	PFAM Sporulation and spore germination
GNK04_RS15870	COG1846	Transcriptional regulator
GNK04_RS15880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNK04_RS15885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNK04_RS15885	COG2190	(PTS) system
GNK04_RS15885	COG1263	PTS System
GNK04_RS15890	COG3711	transcriptional antiterminator
GNK04_RS15895	COG2197	response regulator
GNK04_RS15900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GNK04_RS15905	COG1053	succinate dehydrogenase
GNK04_RS15910	COG2009	succinate dehydrogenase
GNK04_RS15915	COG1719	4-vinyl reductase, 4VR
GNK04_RS15945	COG1216	Glycosyl transferase, family 2
GNK04_RS15970	COG3118	belongs to the thioredoxin family
GNK04_RS15975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GNK04_RS15980	COG2086	electron transfer activity
GNK04_RS15985	COG1024	Enoyl-CoA hydratase
GNK04_RS15990	COG1309	transcriptional regulator
GNK04_RS15995	COG0318	PFAM AMP-dependent synthetase and ligase
GNK04_RS16000	COG3766	membrane
GNK04_RS16005	COG1193	negative regulation of DNA recombination
GNK04_RS16010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GNK04_RS16010	COG1796	DNA polymerase
GNK04_RS16020	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GNK04_RS16025	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GNK04_RS16035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GNK04_RS16040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNK04_RS16040	COG0072	phenylalanine-tRNA ligase activity
GNK04_RS16045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GNK04_RS16050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GNK04_RS16060	COG1363	Peptidase, m42
GNK04_RS16080	COG1271	oxidase subunit
GNK04_RS16085	COG1294	oxidase, subunit
GNK04_RS16100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GNK04_RS16105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GNK04_RS16110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GNK04_RS16120	COG1484	DNA-dependent DNA replication
GNK04_RS16125	COG3611	Membrane attachment protein
GNK04_RS16130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GNK04_RS16145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GNK04_RS16155	COG1971	Probably functions as a manganese efflux pump
GNK04_RS16165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GNK04_RS16165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GNK04_RS16170	COG5002	protein histidine kinase activity
GNK04_RS16175	COG0745	RESPONSE REGULATOR receiver
GNK04_RS16185	COG0039	L-malate dehydrogenase activity
GNK04_RS16190	COG0538	isocitrate dehydrogenase activity
GNK04_RS16195	COG0372	Belongs to the citrate synthase family
GNK04_RS16200	COG2707	UPF0756 membrane protein
GNK04_RS16205	COG0628	permease
GNK04_RS16215	COG0778	Nitroreductase
GNK04_RS16220	COG1846	Transcriptional regulator
GNK04_RS16225	COG3030	protein affecting phage T7 exclusion by the F plasmid
GNK04_RS16235	COG0205	6-phosphofructokinase activity
GNK04_RS16240	COG0825	malonyl-CoA metabolic process
GNK04_RS16245	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GNK04_RS16250	COG2186	Transcriptional regulator
GNK04_RS16255	COG0281	malic enzyme
GNK04_RS16260	COG0587	DNA-directed DNA polymerase activity
GNK04_RS16280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GNK04_RS16290	COG4109	DRTGG domain
GNK04_RS16300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GNK04_RS16305	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GNK04_RS16310	COG3766	membrane
GNK04_RS16320	COG1842	Phage shock protein A
GNK04_RS16340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GNK04_RS16345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GNK04_RS16370	COG2217	Heavy metal translocating P-type atpase
GNK04_RS16375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GNK04_RS16380	COG0827	DNA restriction-modification system
GNK04_RS16385	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GNK04_RS16390	COG3874	Sporulation protein YtfJ
GNK04_RS16400	COG1714	RDD family
GNK04_RS16405	COG0616	signal peptide processing
GNK04_RS16410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GNK04_RS16415	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GNK04_RS16420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GNK04_RS16425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GNK04_RS16440	COG1104	cysteine desulfurase activity
GNK04_RS16445	COG1114	Component of the transport system for branched-chain amino acids
GNK04_RS16450	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GNK04_RS16455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GNK04_RS16460	COG1309	transcriptional regulator
GNK04_RS16465	COG1956	GAF domain-containing protein
GNK04_RS16470	COG0626	cystathionine gamma-synthase activity
GNK04_RS16475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GNK04_RS16480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GNK04_RS16490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GNK04_RS16495	COG0454	-acetyltransferase
GNK04_RS16500	COG0517	IMP dehydrogenase activity
GNK04_RS16505	COG0123	including yeast histone deacetylase and acetoin utilization protein
GNK04_RS16515	COG1605	Chorismate mutase
GNK04_RS16515	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GNK04_RS16520	COG3118	belongs to the thioredoxin family
GNK04_RS16525	COG4980	gas vesicle protein
GNK04_RS16535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GNK04_RS16545	COG1674	ftsk spoiiie
GNK04_RS16550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNK04_RS16555	COG4848	Belongs to the UPF0354 family
GNK04_RS16560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNK04_RS16575	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GNK04_RS16580	COG1363	Peptidase, m42
GNK04_RS16595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GNK04_RS16600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNK04_RS16600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNK04_RS16600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNK04_RS16605	COG1105	Belongs to the carbohydrate kinase PfkB family
GNK04_RS16610	COG1349	DNA-binding transcription factor activity
GNK04_RS16615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNK04_RS16620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GNK04_RS16630	COG0510	thiamine kinase activity
GNK04_RS16635	COG1523	belongs to the glycosyl hydrolase 13 family
GNK04_RS16640	COG1346	cytolysis
GNK04_RS16645	COG1380	Effector of murein hydrolase LrgA
GNK04_RS16650	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GNK04_RS16655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GNK04_RS16660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GNK04_RS16665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNK04_RS16670	COG1349	DNA-binding transcription factor activity
GNK04_RS16680	COG1187	pseudouridine synthase activity
GNK04_RS16695	COG2244	polysaccharide biosynthetic process
GNK04_RS16700	COG2081	HI0933 family
GNK04_RS16710	COG0741	lytic transglycosylase activity
GNK04_RS16720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNK04_RS16725	COG0495	leucyl-tRNA aminoacylation
GNK04_RS16735	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GNK04_RS16750	COG2267	carboxylic ester hydrolase activity
GNK04_RS16755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GNK04_RS16765	COG0671	phosphoesterase, PA-phosphatase related
GNK04_RS16775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GNK04_RS16785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GNK04_RS16790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GNK04_RS16795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GNK04_RS16800	COG1116	anion transmembrane transporter activity
GNK04_RS16805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GNK04_RS16810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GNK04_RS16815	COG0494	nUDIX hydrolase
GNK04_RS16845	COG0210	DNA helicase
GNK04_RS16855	COG2814	Major facilitator Superfamily
GNK04_RS16860	COG4948	Mandelate Racemase Muconate Lactonizing
GNK04_RS16865	COG0318	PFAM AMP-dependent synthetase and ligase
GNK04_RS16870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GNK04_RS16875	COG2267	carboxylic ester hydrolase activity
GNK04_RS16880	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GNK04_RS16885	COG1169	isochorismate synthase
GNK04_RS16895	COG1575	Belongs to the MenA family. Type 1 subfamily
GNK04_RS16900	COG2050	protein possibly involved in aromatic compounds catabolism
GNK04_RS16910	COG1525	nuclease
GNK04_RS16920	COG1132	(ABC) transporter
GNK04_RS16925	COG1132	(ABC) transporter
GNK04_RS16940	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS16945	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GNK04_RS16950	COG1657	PFAM Prenyltransferase squalene oxidase
GNK04_RS16960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GNK04_RS16965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GNK04_RS16970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GNK04_RS16980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNK04_RS16990	COG2843	Capsule synthesis protein
GNK04_RS16995	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS17005	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GNK04_RS17025	COG2204	response regulator
GNK04_RS17040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GNK04_RS17045	COG2311	Membrane
GNK04_RS17050	COG1595	DNA-templated transcription, initiation
GNK04_RS17060	COG4325	translation initiation factor activity
GNK04_RS17070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GNK04_RS17075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GNK04_RS17090	COG2364	Membrane
GNK04_RS17095	COG3584	3D domain protein
GNK04_RS17095	COG1388	LysM domain
GNK04_RS17100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GNK04_RS17105	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GNK04_RS17115	COG2310	stress, protein
GNK04_RS17145	COG4842	Belongs to the WXG100 family
GNK04_RS17150	COG5417	Belongs to the EsaB family
GNK04_RS17155	COG4499	WXG100 protein secretion system (Wss), protein YukC
GNK04_RS17160	COG1674	ftsk spoiiie
GNK04_RS17160	COG0433	COG0433 Predicted ATPase
GNK04_RS17165	COG1511	domain protein
GNK04_RS17190	COG0747	negative chemotaxis
GNK04_RS17200	COG5444	nuclease activity
GNK04_RS17210	COG2304	oxidoreductase activity
GNK04_RS17215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNK04_RS17220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GNK04_RS17225	COG0523	cobalamin synthesis protein
GNK04_RS17240	COG0701	Predicted permease
GNK04_RS17245	COG0523	cobalamin synthesis protein
GNK04_RS17255	COG2304	oxidoreductase activity
GNK04_RS17270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GNK04_RS17280	COG1621	beta-fructofuranosidase activity
GNK04_RS17290	COG1609	Transcriptional regulator
GNK04_RS17295	COG1621	beta-fructofuranosidase activity
GNK04_RS17300	COG1621	beta-fructofuranosidase activity
GNK04_RS17305	COG1653	transport
GNK04_RS17310	COG0395	ABC-type sugar transport system, permease component
GNK04_RS17315	COG4209	transmembrane transport
GNK04_RS17320	COG1063	alcohol dehydrogenase
GNK04_RS17335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNK04_RS17350	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GNK04_RS17360	COG1510	regulation of RNA biosynthetic process
GNK04_RS17365	COG2113	Glycine betaine
GNK04_RS17390	COG0165	Argininosuccinate lyase
GNK04_RS17395	COG4149	molybdate abc transporter
GNK04_RS17400	COG3842	ATPase activity
GNK04_RS17405	COG1840	ABC-type Fe3 transport system, periplasmic component
GNK04_RS17410	COG1940	carbohydrate kinase activity
GNK04_RS17425	COG2423	ornithine cyclodeaminase activity
GNK04_RS17450	COG2323	membrane
GNK04_RS17455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GNK04_RS17455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GNK04_RS17460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GNK04_RS17465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GNK04_RS17470	COG0698	ribose 5-phosphate isomerase
GNK04_RS17490	COG1024	Enoyl-CoA hydratase
GNK04_RS17525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GNK04_RS17540	COG1082	Xylose isomerase domain protein TIM barrel
GNK04_RS17545	COG1172	Belongs to the binding-protein-dependent transport system permease family
GNK04_RS17550	COG1129	ABC transporter
GNK04_RS17555	COG0673	inositol 2-dehydrogenase activity
GNK04_RS17565	COG0673	inositol 2-dehydrogenase activity
GNK04_RS17580	COG5577	PFAM Coat F domain
GNK04_RS17590	COG1063	alcohol dehydrogenase
GNK04_RS17595	COG5577	PFAM Coat F domain
GNK04_RS17610	COG0656	L-ascorbic acid biosynthetic process
GNK04_RS17620	COG0693	protein deglycase activity
GNK04_RS17630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNK04_RS17640	COG0640	Transcriptional regulator
GNK04_RS17655	COG3550	peptidyl-serine autophosphorylation
GNK04_RS17695	COG4974	Belongs to the 'phage' integrase family
GNK04_RS17700	COG4974	Belongs to the 'phage' integrase family
GNK04_RS17715	COG0583	DNA-binding transcription factor activity
GNK04_RS17735	COG0346	lactoylglutathione lyase activity
GNK04_RS17740	COG0402	S-adenosylhomocysteine deaminase activity
GNK04_RS17760	COG0697	spore germination
GNK04_RS17765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNK04_RS17770	COG0697	spore germination
GNK04_RS17780	COG5002	protein histidine kinase activity
GNK04_RS17780	COG3850	Histidine kinase
GNK04_RS17785	COG0577	efflux transmembrane transporter activity
GNK04_RS17790	COG1136	(ABC) transporter
GNK04_RS17795	COG0431	NADPH-dependent FMN reductase
GNK04_RS17800	COG0655	NAD(P)H dehydrogenase (quinone) activity
GNK04_RS17805	COG0400	carboxylic ester hydrolase activity
GNK04_RS17810	COG0346	lactoylglutathione lyase activity
GNK04_RS17815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GNK04_RS17820	COG0346	lactoylglutathione lyase activity
GNK04_RS17825	COG0582	viral genome integration into host DNA
GNK04_RS17845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GNK04_RS17860	COG1979	alcohol dehydrogenase
GNK04_RS17865	COG2155	Conserved Protein
GNK04_RS17870	COG1098	S1 RNA binding domain
GNK04_RS17875	COG0733	neurotransmitter:sodium symporter activity
GNK04_RS17880	COG2267	carboxylic ester hydrolase activity
GNK04_RS17895	COG4585	Histidine kinase
GNK04_RS17900	COG2197	response regulator
GNK04_RS17910	COG0725	ABC transporter, periplasmic molybdate-binding protein
GNK04_RS17915	COG4149	molybdate abc transporter
GNK04_RS17935	COG1366	Belongs to the anti-sigma-factor antagonist family
GNK04_RS17935	COG2202	Pas domain
GNK04_RS17940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GNK04_RS17945	COG2056	Na+-H+ antiporter family
GNK04_RS17950	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GNK04_RS17960	COG3584	3D domain protein
GNK04_RS17980	COG1252	NADH dehydrogenase
GNK04_RS17985	COG0492	ferredoxin-NADP+ reductase activity
GNK04_RS17995	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS18000	COG1082	Xylose isomerase domain protein TIM barrel
GNK04_RS18005	COG0673	inositol 2-dehydrogenase activity
GNK04_RS18010	COG0673	inositol 2-dehydrogenase activity
GNK04_RS18035	COG1609	Transcriptional regulator
GNK04_RS18050	COG0316	Belongs to the HesB IscA family
GNK04_RS18055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GNK04_RS18065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GNK04_RS18075	COG1252	NADH dehydrogenase
GNK04_RS18085	COG4837	Protein of unknown function (DUF1462)
GNK04_RS18090	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GNK04_RS18095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GNK04_RS18100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GNK04_RS18105	COG0647	UMP catabolic process
GNK04_RS18110	COG2445	Protein of unknown function DUF86
GNK04_RS18125	COG4470	Protein conserved in bacteria
GNK04_RS18135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GNK04_RS18140	COG0739	heme binding
GNK04_RS18150	COG0733	neurotransmitter:sodium symporter activity
GNK04_RS18155	COG1757	Na H antiporter
GNK04_RS18170	COG3377	Domain of unknown function (DUF1805)
GNK04_RS18180	COG0730	response to heat
GNK04_RS18185	COG1801	Protein of unknown function DUF72
GNK04_RS18190	COG0719	Fe-S assembly protein
GNK04_RS18195	COG0822	iron-sulfur transferase activity
GNK04_RS18200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GNK04_RS18205	COG0719	Fe-S assembly protein
GNK04_RS18210	COG0396	ATPase activity
GNK04_RS18215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GNK04_RS18220	COG0039	L-malate dehydrogenase activity
GNK04_RS18225	COG1464	Belongs to the NlpA lipoprotein family
GNK04_RS18230	COG2011	ABC-type metal ion transport system permease component
GNK04_RS18235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GNK04_RS18240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GNK04_RS18245	COG0066	3-isopropylmalate dehydratase activity
GNK04_RS18250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GNK04_RS18260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GNK04_RS18265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GNK04_RS18270	COG0440	acetolactate synthase activity
GNK04_RS18275	COG0028	Belongs to the TPP enzyme family
GNK04_RS18290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GNK04_RS18305	COG1191	sigma factor activity
GNK04_RS18315	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GNK04_RS18320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GNK04_RS18335	COG0509	glycine decarboxylation via glycine cleavage system
GNK04_RS18340	COG1393	Belongs to the ArsC family
GNK04_RS18345	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS18350	COG0183	Belongs to the thiolase family
GNK04_RS18355	COG1250	3-hydroxyacyl-CoA dehydrogenase
GNK04_RS18355	COG1024	Enoyl-CoA hydratase
GNK04_RS18375	COG1233	COG1233 Phytoene dehydrogenase and related
GNK04_RS18385	COG1272	protein, Hemolysin III
GNK04_RS18390	COG1131	(ABC) transporter
GNK04_RS18400	COG1595	DNA-templated transcription, initiation
GNK04_RS18410	COG1131	(ABC) transporter
GNK04_RS18415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GNK04_RS18420	COG0662	Cupin 2, conserved barrel domain protein
GNK04_RS18430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GNK04_RS18445	COG0776	regulation of translation
GNK04_RS18450	COG2258	MOSC domain
GNK04_RS18460	COG1309	transcriptional regulator
GNK04_RS18465	COG1131	(ABC) transporter
GNK04_RS18550	COG2329	Antibiotic biosynthesis monooxygenase
GNK04_RS18555	COG0217	transcriptional regulatory protein
GNK04_RS18570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GNK04_RS18580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GNK04_RS18585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GNK04_RS18590	COG5002	protein histidine kinase activity
GNK04_RS18595	COG0745	RESPONSE REGULATOR receiver
GNK04_RS18605	COG3264	Mechanosensitive ion channel
GNK04_RS18605	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GNK04_RS18615	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GNK04_RS18620	COG1131	(ABC) transporter
GNK04_RS18625	COG1131	(ABC) transporter
GNK04_RS18630	COG1725	Transcriptional regulator
GNK04_RS18645	COG1115	amino acid carrier protein
GNK04_RS18650	COG0702	epimerase
GNK04_RS18660	COG1902	pentaerythritol trinitrate reductase activity
GNK04_RS18665	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GNK04_RS18675	COG1193	negative regulation of DNA recombination
GNK04_RS18680	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS18685	COG1115	amino acid carrier protein
GNK04_RS18690	COG1132	(ABC) transporter
GNK04_RS18695	COG0778	Nitroreductase
GNK04_RS18715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNK04_RS18720	COG1349	DNA-binding transcription factor activity
GNK04_RS18725	COG0788	formyltetrahydrofolate deformylase activity
GNK04_RS18750	COG0398	Pfam SNARE associated Golgi protein
GNK04_RS18755	COG1253	flavin adenine dinucleotide binding
GNK04_RS18760	COG0730	response to heat
GNK04_RS18765	COG0425	Belongs to the sulfur carrier protein TusA family
GNK04_RS18770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNK04_RS18770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNK04_RS18775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNK04_RS18775	COG0425	Belongs to the sulfur carrier protein TusA family
GNK04_RS18790	COG2210	Belongs to the sulfur carrier protein TusA family
GNK04_RS18795	COG1937	Protein conserved in bacteria
GNK04_RS18800	COG2149	membrane
GNK04_RS18805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GNK04_RS18805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GNK04_RS18810	COG1733	regulation of RNA biosynthetic process
GNK04_RS18815	COG3594	Acyltransferase
GNK04_RS18820	COG1966	Carbon starvation protein
GNK04_RS18825	COG0778	Nitroreductase
GNK04_RS18830	COG0673	inositol 2-dehydrogenase activity
GNK04_RS18835	COG2357	RelA SpoT domain protein
GNK04_RS18840	COG2031	fatty acid transporter
GNK04_RS18845	COG2368	4-hydroxyphenylacetate
GNK04_RS18870	COG0129	dihydroxy-acid dehydratase activity
GNK04_RS18895	COG0583	DNA-binding transcription factor activity
GNK04_RS18915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GNK04_RS18920	COG0557	exoribonuclease II activity
GNK04_RS18925	COG1647	Serine aminopeptidase, S33
GNK04_RS18930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GNK04_RS18935	COG0148	phosphopyruvate hydratase activity
GNK04_RS18940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GNK04_RS18970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GNK04_RS18990	COG0740	serine-type endopeptidase activity
GNK04_RS18995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNK04_RS19000	COG1481	regulation of sporulation
GNK04_RS19005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GNK04_RS19010	COG1660	Displays ATPase and GTPase activities
GNK04_RS19015	COG1051	belongs to the nudix hydrolase family
GNK04_RS19020	COG0492	ferredoxin-NADP+ reductase activity
GNK04_RS19025	COG0457	Tetratricopeptide repeat
GNK04_RS19030	COG0140	phosphoribosyl-ATP diphosphatase activity
GNK04_RS19030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GNK04_RS19035	COG0107	imidazoleglycerol-phosphate synthase activity
GNK04_RS19040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GNK04_RS19045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GNK04_RS19050	COG0131	Imidazoleglycerol-phosphate dehydratase
GNK04_RS19055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GNK04_RS19060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GNK04_RS19065	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GNK04_RS19070	COG0387	Pfam Sodium calcium exchanger
GNK04_RS19075	COG0024	Methionine aminopeptidase
GNK04_RS19080	COG0110	maltose O-acetyltransferase activity
GNK04_RS19090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GNK04_RS19105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GNK04_RS19115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GNK04_RS19120	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GNK04_RS19125	COG1950	PFAM Membrane protein of
GNK04_RS19130	COG3595	metallopeptidase activity
GNK04_RS19140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GNK04_RS19145	COG0556	nucleotide-excision repair
GNK04_RS19160	COG1607	acyl-coa hydrolase
GNK04_RS19170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNK04_RS19175	COG0793	Belongs to the peptidase S41A family
GNK04_RS19175	COG3409	Peptidoglycan-binding domain 1 protein
GNK04_RS19180	COG0739	heme binding
GNK04_RS19185	COG2177	Part of the ABC transporter FtsEX involved in
GNK04_RS19190	COG2884	Cell division ATP-binding protein ftsE
GNK04_RS19200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNK04_RS19210	COG0653	protein targeting
GNK04_RS19215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GNK04_RS19220	COG1278	Cold shock
GNK04_RS19225	COG1040	competence protein
GNK04_RS19230	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GNK04_RS19235	COG1307	EDD domain protein, DegV family
GNK04_RS19240	COG1388	LysM domain
GNK04_RS19240	COG0791	NLP P60 protein
GNK04_RS19255	COG1739	Uncharacterized protein family UPF0029
GNK04_RS19260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GNK04_RS19265	COG1316	TRANSCRIPTIONal
GNK04_RS19280	COG0438	transferase activity, transferring glycosyl groups
GNK04_RS19295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GNK04_RS19330	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS19335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GNK04_RS19345	COG2247	cell wall binding repeat
GNK04_RS19345	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS19360	COG0457	Tetratricopeptide repeat
GNK04_RS19385	COG2385	sporulation resulting in formation of a cellular spore
GNK04_RS19385	COG2247	cell wall binding repeat
GNK04_RS19410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GNK04_RS19420	COG2427	Protein of unknown function (DUF1641)
GNK04_RS19425	COG3383	formate dehydrogenase (NAD+) activity
GNK04_RS19440	COG2308	Evidence 4 Homologs of previously reported genes of
GNK04_RS19450	COG1175	transmembrane transport
GNK04_RS19465	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNK04_RS19465	COG0596	Alpha beta hydrolase
GNK04_RS19470	COG2207	Transcriptional regulator
GNK04_RS19470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GNK04_RS19475	COG2972	Histidine kinase
GNK04_RS19490	COG1132	(ABC) transporter
GNK04_RS19495	COG1132	(ABC) transporter
GNK04_RS19500	COG1482	cell wall glycoprotein biosynthetic process
GNK04_RS19505	COG1940	carbohydrate kinase activity
GNK04_RS19515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GNK04_RS19525	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GNK04_RS19530	COG1454	alcohol dehydrogenase
GNK04_RS19545	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS19555	COG1609	Transcriptional regulator
GNK04_RS19560	COG0205	6-phosphofructokinase activity
GNK04_RS19570	COG1501	Belongs to the glycosyl hydrolase 31 family
GNK04_RS19575	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNK04_RS19605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GNK04_RS19610	COG1874	Beta-galactosidase
GNK04_RS19615	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GNK04_RS19620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GNK04_RS19625	COG1609	Transcriptional regulator
GNK04_RS19650	COG1653	transport
GNK04_RS19660	COG1696	Membrane protein involved in D-alanine export
GNK04_RS19670	COG2226	methyltransferase
GNK04_RS19675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GNK04_RS19685	COG1682	transport, permease protein
GNK04_RS19690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GNK04_RS19695	COG0463	Glycosyl transferase, family 2
GNK04_RS19695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GNK04_RS19700	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GNK04_RS19715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GNK04_RS19745	COG0371	Dehydrogenase
GNK04_RS19750	COG1304	FMN binding
GNK04_RS19755	COG2011	ABC-type metal ion transport system permease component
GNK04_RS19760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GNK04_RS19770	COG4946	Tricorn protease homolog
GNK04_RS19770	COG1506	peptidase
GNK04_RS19770	COG0823	Involved in the tonB-independent uptake of proteins
GNK04_RS19780	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GNK04_RS19790	COG0395	ABC-type sugar transport system, permease component
GNK04_RS19800	COG1653	transport
GNK04_RS19810	COG1737	Transcriptional regulator
GNK04_RS19815	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GNK04_RS19825	COG1263	PTS System
GNK04_RS19825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNK04_RS19830	COG3876	Protein conserved in bacteria
GNK04_RS19835	COG1472	Belongs to the glycosyl hydrolase 3 family
GNK04_RS19840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GNK04_RS19845	COG3181	Tripartite tricarboxylate transporter family receptor
GNK04_RS19860	COG4565	transcriptional regulatory protein
GNK04_RS19865	COG3290	protein histidine kinase activity
GNK04_RS19870	COG1957	nucleoside hydrolase
GNK04_RS19875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GNK04_RS19880	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GNK04_RS19885	COG3457	Alanine racemase
GNK04_RS19890	COG0626	cystathionine gamma-synthase activity
GNK04_RS19895	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GNK04_RS19915	COG2188	Transcriptional regulator
GNK04_RS19920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GNK04_RS19940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GNK04_RS19950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GNK04_RS19955	COG1609	Transcriptional regulator
GNK04_RS19965	COG0584	glycerophosphoryl diester phosphodiesterase
GNK04_RS19985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GNK04_RS19990	COG0824	Thioesterase
GNK04_RS20005	COG2234	aminopeptidase activity
GNK04_RS20010	COG4145	pantothenate transmembrane transporter activity
GNK04_RS20030	COG1285	pathogenesis
GNK04_RS20035	COG1285	pathogenesis
GNK04_RS20040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNK04_RS20055	COG0367	asparagine synthase
GNK04_RS20060	COG3104	oligopeptide transport
GNK04_RS20065	COG0205	6-phosphofructokinase activity
GNK04_RS20075	COG1175	transmembrane transport
GNK04_RS20090	COG0673	inositol 2-dehydrogenase activity
GNK04_RS20100	COG0531	amino acid
GNK04_RS20105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GNK04_RS20110	COG1802	Transcriptional regulator
GNK04_RS20115	COG2059	Chromate
GNK04_RS20120	COG2059	Chromate
GNK04_RS20130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GNK04_RS20135	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GNK04_RS20140	COG1070	Carbohydrate kinase
GNK04_RS20145	COG2115	Belongs to the xylose isomerase family
GNK04_RS20150	COG5578	integral membrane protein
GNK04_RS20155	COG2814	Major facilitator Superfamily
GNK04_RS20155	COG0477	Major facilitator Superfamily
GNK04_RS20165	COG0395	ABC-type sugar transport system, permease component
GNK04_RS20170	COG1175	transmembrane transport
GNK04_RS20175	COG1653	transport
GNK04_RS20200	COG0697	spore germination
GNK04_RS20210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GNK04_RS20215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GNK04_RS20220	COG2267	carboxylic ester hydrolase activity
GNK04_RS20225	COG0673	inositol 2-dehydrogenase activity
GNK04_RS20230	COG0673	inositol 2-dehydrogenase activity
GNK04_RS20240	COG1175	transmembrane transport
GNK04_RS20245	COG1653	transport
GNK04_RS20255	COG1609	Transcriptional regulator
GNK04_RS20280	COG5002	protein histidine kinase activity
GNK04_RS20295	COG1595	DNA-templated transcription, initiation
GNK04_RS20300	COG0791	NLP P60 protein
GNK04_RS20300	COG1388	LysM domain
GNK04_RS20305	COG1523	belongs to the glycosyl hydrolase 13 family
GNK04_RS20310	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS20310	COG2247	cell wall binding repeat
GNK04_RS20330	COG1070	Carbohydrate kinase
GNK04_RS20335	COG0277	FAD linked oxidase domain protein
GNK04_RS20340	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS20375	COG2814	Major facilitator Superfamily
GNK04_RS20395	COG1136	(ABC) transporter
GNK04_RS20400	COG0577	efflux transmembrane transporter activity
GNK04_RS20455	COG3279	Response regulator of the LytR AlgR family
GNK04_RS20470	COG2176	DNA-directed DNA polymerase activity
GNK04_RS20480	COG0004	ammonium transporteR
GNK04_RS20485	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GNK04_RS20540	COG3157	Type VI secretion system effector, Hcp
GNK04_RS20545	COG5444	nuclease activity
GNK04_RS20565	COG0318	PFAM AMP-dependent synthetase and ligase
GNK04_RS20580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNK04_RS20590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GNK04_RS20615	COG1653	transport
GNK04_RS20620	COG1609	Transcriptional regulator
GNK04_RS20625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GNK04_RS20645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GNK04_RS20650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GNK04_RS20670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GNK04_RS20675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GNK04_RS20685	COG1396	sequence-specific DNA binding
GNK04_RS20695	COG1086	Polysaccharide biosynthesis protein
GNK04_RS20700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GNK04_RS20705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GNK04_RS20750	COG0395	ABC-type sugar transport system, permease component
GNK04_RS20755	COG1175	transmembrane transport
GNK04_RS20770	COG1349	DNA-binding transcription factor activity
GNK04_RS20775	COG0191	fructose-bisphosphate aldolase activity
GNK04_RS20785	COG1070	Carbohydrate kinase
GNK04_RS20805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GNK04_RS20815	COG1063	alcohol dehydrogenase
GNK04_RS20820	COG1917	Cupin 2, conserved barrel domain protein
GNK04_RS20840	COG0438	transferase activity, transferring glycosyl groups
GNK04_RS20880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GNK04_RS20885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GNK04_RS20890	COG1086	Polysaccharide biosynthesis protein
GNK04_RS20900	COG0489	protein tyrosine kinase activity
GNK04_RS20905	COG3944	biosynthesis protein
GNK04_RS20910	COG4464	protein tyrosine phosphatase activity
GNK04_RS20915	COG1316	TRANSCRIPTIONal
GNK04_RS20930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GNK04_RS20935	COG0460	homoserine dehydrogenase
GNK04_RS20975	COG1091	dTDP-4-dehydrorhamnose reductase activity
GNK04_RS20990	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GNK04_RS21005	COG0489	protein tyrosine kinase activity
GNK04_RS21010	COG3944	biosynthesis protein
GNK04_RS21025	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS21045	COG3409	Peptidoglycan-binding domain 1 protein
GNK04_RS21045	COG3773	Cell wall hydrolase
GNK04_RS21065	COG1621	beta-fructofuranosidase activity
GNK04_RS21070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNK04_RS21070	COG1263	PTS System
GNK04_RS21090	COG2096	Adenosyltransferase
GNK04_RS21105	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GNK04_RS21110	COG1492	cobalamin metabolic process
GNK04_RS21115	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
GNK04_RS21125	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GNK04_RS21130	COG1120	ATPase activity
GNK04_RS21135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNK04_RS21140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GNK04_RS21145	COG0577	efflux transmembrane transporter activity
GNK04_RS21145	COG1136	(ABC) transporter
GNK04_RS21150	COG1136	(ABC) transporter
GNK04_RS21150	COG0577	efflux transmembrane transporter activity
GNK04_RS21155	COG5002	protein histidine kinase activity
GNK04_RS21155	COG3850	Histidine kinase
GNK04_RS21160	COG0745	RESPONSE REGULATOR receiver
GNK04_RS21165	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GNK04_RS21175	COG2259	Doxx family
GNK04_RS21190	COG2046	Belongs to the sulfate adenylyltransferase family
GNK04_RS21195	COG3273	potassium ion transport
GNK04_RS21195	COG0471	metal ion transport
GNK04_RS21200	COG0529	Catalyzes the synthesis of activated sulfate
GNK04_RS21305	COG2247	cell wall binding repeat
GNK04_RS21305	COG2385	sporulation resulting in formation of a cellular spore
GNK04_RS21310	COG0791	NLP P60 protein
GNK04_RS21310	COG1388	LysM domain
GNK04_RS21315	COG2247	cell wall binding repeat
GNK04_RS21315	COG2385	sporulation resulting in formation of a cellular spore
GNK04_RS21320	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNK04_RS21320	COG2247	cell wall binding repeat
GNK04_RS21325	COG0737	Belongs to the 5'-nucleotidase family
GNK04_RS21330	COG2385	sporulation resulting in formation of a cellular spore
GNK04_RS21330	COG2247	cell wall binding repeat
GNK04_RS21335	COG0758	DNA mediated transformation
GNK04_RS21350	COG0346	lactoylglutathione lyase activity
GNK04_RS21355	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS21360	COG1028	Short-chain dehydrogenase reductase Sdr
GNK04_RS21365	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GNK04_RS21370	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GNK04_RS21375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GNK04_RS21380	COG1802	Transcriptional regulator
GNK04_RS21390	COG1396	sequence-specific DNA binding
GNK04_RS21430	COG1077	Cell shape determining protein MreB Mrl
GNK04_RS21435	COG1609	Transcriptional regulator
GNK04_RS21440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNK04_RS21455	COG0739	heme binding
GNK04_RS21465	COG2385	sporulation resulting in formation of a cellular spore
GNK04_RS21470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GNK04_RS21480	COG4836	Membrane
GNK04_RS21485	COG1007	ATP synthesis coupled electron transport
GNK04_RS21495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GNK04_RS21500	COG0713	ATP synthesis coupled electron transport
GNK04_RS21510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GNK04_RS21515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GNK04_RS21520	COG0649	NAD binding
GNK04_RS21525	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GNK04_RS21530	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GNK04_RS21550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GNK04_RS21560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GNK04_RS21565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GNK04_RS21575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GNK04_RS21580	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GNK04_RS21585	COG0356	it plays a direct role in the translocation of protons across the membrane
GNK04_RS21600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GNK04_RS21610	COG4475	Protein of unknown function (DUF436)
GNK04_RS21615	COG0698	ribose 5-phosphate isomerase
GNK04_RS21625	COG0330	HflC and HflK could
GNK04_RS21635	COG1971	Probably functions as a manganese efflux pump
GNK04_RS21645	COG0009	L-threonylcarbamoyladenylate synthase
GNK04_RS21665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GNK04_RS21670	COG0446	pyridine nucleotide-disulphide oxidoreductase
GNK04_RS21680	COG1435	thymidine kinase activity
GNK04_RS21690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GNK04_RS21695	COG1494	fructose-1,6-bisphosphatase
GNK04_RS21700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GNK04_RS21705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GNK04_RS21710	COG0191	fructose-bisphosphate aldolase activity
GNK04_RS21715	COG2204	response regulator
GNK04_RS21725	COG0504	CTP synthase activity
GNK04_RS21730	COG3343	RNA polymerase activity
GNK04_RS21735	COG1703	isobutyryl-CoA mutase activity
GNK04_RS21735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GNK04_RS21735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GNK04_RS21740	COG1309	transcriptional regulator
GNK04_RS21750	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS21755	COG1960	acyl-CoA dehydrogenase activity
GNK04_RS21760	COG1250	3-hydroxyacyl-CoA dehydrogenase
GNK04_RS21765	COG0183	Belongs to the thiolase family
GNK04_RS21770	COG0247	lactate metabolic process
GNK04_RS21770	COG2181	nitrate reductase activity
GNK04_RS21775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GNK04_RS21780	COG4294	response to UV
GNK04_RS21785	COG0596	Alpha beta hydrolase
GNK04_RS21805	COG0010	Belongs to the arginase family
GNK04_RS21810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GNK04_RS21820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GNK04_RS21835	COG2252	PERMEase
GNK04_RS21840	COG0673	inositol 2-dehydrogenase activity
GNK04_RS21850	COG3465	dGTPase activity
GNK04_RS21855	COG1078	dGTPase activity
GNK04_RS21860	COG1301	dicarboxylic acid transport
GNK04_RS21865	COG0095	Lipoate-protein ligase
GNK04_RS21870	COG0280	phosphate acetyltransferase
GNK04_RS21885	COG2363	Small membrane protein
GNK04_RS21890	COG4473	ABC transporter
GNK04_RS21895	COG1131	(ABC) transporter
GNK04_RS21915	COG1728	Protein conserved in bacteria
GNK04_RS21925	COG1191	sigma factor activity
GNK04_RS21930	COG0455	bacterial-type flagellum organization
GNK04_RS21935	COG1419	protein localization to endoplasmic reticulum
GNK04_RS21940	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GNK04_RS21945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GNK04_RS21950	COG1684	flagellar biosynthetic protein fliR
GNK04_RS21955	COG1987	bacterial-type flagellum assembly
GNK04_RS21960	COG1338	Plays a role in the flagellum-specific transport system
GNK04_RS21965	COG3190	flagellar
GNK04_RS21970	COG1776	CheC inhibitor of MCP methylation
GNK04_RS21970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GNK04_RS21975	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GNK04_RS21985	COG4786	Flagellar basal body rod
GNK04_RS21995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GNK04_RS22015	COG1157	protein secretion by the type III secretion system
GNK04_RS22025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GNK04_RS22030	COG1766	The M ring may be actively involved in energy transduction
GNK04_RS22035	COG1677	Flagellar hook-basal body complex protein FliE
GNK04_RS22040	COG1558	bacterial-type flagellum-dependent cell motility
GNK04_RS22045	COG1815	bacterial-type flagellum-dependent cell motility
GNK04_RS22050	COG4786	Flagellar basal body rod
GNK04_RS22060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GNK04_RS22065	COG1256	bacterial-type flagellum assembly
GNK04_RS22065	COG4786	Flagellar basal body rod
GNK04_RS22085	COG1360	Flagellar Motor Protein
GNK04_RS22090	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GNK04_RS22095	COG1516	flagellar protein fliS
GNK04_RS22105	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GNK04_RS22110	COG1334	flagellar protein FlaG
GNK04_RS22115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GNK04_RS22125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GNK04_RS22130	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GNK04_RS22135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GNK04_RS22140	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GNK04_RS22145	COG1984	allophanate hydrolase subunit 2
GNK04_RS22170	COG0288	reversible hydration of carbon dioxide
GNK04_RS22175	COG0693	protein deglycase activity
GNK04_RS22180	COG0861	Integral membrane protein TerC family
GNK04_RS22225	COG4129	membrane
GNK04_RS22240	COG0386	Belongs to the glutathione peroxidase family
GNK04_RS22255	COG0154	amidase activity
GNK04_RS22260	COG0697	spore germination
GNK04_RS22275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNK04_RS22280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNK04_RS22285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GNK04_RS22295	COG2270	Major facilitator Superfamily
GNK04_RS22305	COG2084	Dehydrogenase
GNK04_RS22315	COG0655	NAD(P)H dehydrogenase (quinone) activity
GNK04_RS22320	COG1846	Transcriptional regulator
GNK04_RS22325	COG1846	Transcriptional regulator
GNK04_RS22330	COG1764	response to oxidative stress
GNK04_RS22340	COG3706	GGDEF domain
GNK04_RS22350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GNK04_RS22350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GNK04_RS22355	COG2309	aminopeptidase activity
GNK04_RS22365	COG0784	Response regulator, receiver
GNK04_RS22365	COG3437	response regulator, receiver
GNK04_RS22385	COG1301	dicarboxylic acid transport
GNK04_RS22405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNK04_RS22405	COG3711	transcriptional antiterminator
GNK04_RS22430	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS22435	COG0300	oxidoreductase activity
GNK04_RS22440	COG2040	homocysteine
GNK04_RS22445	COG0833	amino acid
GNK04_RS22460	COG0640	Transcriptional regulator
GNK04_RS22500	COG1845	cytochrome c oxidase, subunit III
GNK04_RS22505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GNK04_RS22515	COG1621	beta-fructofuranosidase activity
GNK04_RS22530	COG2814	Major facilitator Superfamily
GNK04_RS22545	COG0551	DNA topoisomerase type I activity
GNK04_RS22545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GNK04_RS22560	COG0366	Alpha amylase catalytic
GNK04_RS22565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GNK04_RS22570	COG1979	alcohol dehydrogenase
GNK04_RS22580	COG1329	Transcriptional regulator
GNK04_RS22585	COG1070	Carbohydrate kinase
GNK04_RS22590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GNK04_RS22595	COG1737	Transcriptional regulator
GNK04_RS22600	COG1902	pentaerythritol trinitrate reductase activity
GNK04_RS22610	COG3383	formate dehydrogenase (NAD+) activity
GNK04_RS22615	COG2197	response regulator
GNK04_RS22620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GNK04_RS22625	COG1012	belongs to the aldehyde dehydrogenase family
GNK04_RS22630	COG1454	alcohol dehydrogenase
GNK04_RS22640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GNK04_RS22645	COG2814	Major facilitator Superfamily
GNK04_RS22675	COG0166	Belongs to the GPI family
GNK04_RS22685	COG4821	SIS domain
GNK04_RS22695	COG0363	glucosamine-6-phosphate deaminase activity
GNK04_RS22700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GNK04_RS22705	COG2190	(PTS) system
GNK04_RS22705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNK04_RS22705	COG1263	PTS System
GNK04_RS22720	COG0579	oxidoreductase
GNK04_RS22725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GNK04_RS22730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GNK04_RS22740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNK04_RS22745	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GNK04_RS22750	COG4853	Protein conserved in bacteria
GNK04_RS22760	COG5002	protein histidine kinase activity
GNK04_RS22765	COG0745	RESPONSE REGULATOR receiver
GNK04_RS22770	COG0739	heme binding
GNK04_RS22800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GNK04_RS22805	COG0305	Participates in initiation and elongation during chromosome replication
GNK04_RS22810	COG0359	binds to the 23S rRNA
GNK04_RS22815	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GNK04_RS22820	COG4241	membrane
GNK04_RS22830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GNK04_RS22835	COG0629	single-stranded DNA binding
GNK04_RS22845	COG0012	GTP binding
GNK04_RS22850	COG4481	Protein conserved in bacteria
GNK04_RS22855	COG0668	transmembrane transport
GNK04_RS22860	COG3949	Membrane
GNK04_RS22875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GNK04_RS22880	COG1475	DNA binding
GNK04_RS22885	COG1192	Involved in chromosome partitioning
GNK04_RS22890	COG1475	DNA binding
GNK04_RS22900	COG0445	tRNA wobble uridine modification
GNK04_RS22905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GNK04_RS22910	COG1847	R3H domain protein
GNK04_RS22915	COG0706	membrane insertase activity
GNK04_RS22930	COG0230	Belongs to the bacterial ribosomal protein bL34 family