locus-tag class description M654_RS00005 ENOG4105CRK lysyL-tRNA synthetase M654_RS00010 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) M654_RS00020 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase M654_RS00025 ENOG4105KRF dihydroneopterin aldolase M654_RS00030 ENOG4105EEI dihydropteroate synthase M654_RS00035 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 M654_RS00040 ENOG4105DDQ anthranilate synthase M654_RS00045 ENOG4105CRQ synthase (Component I) M654_RS00050 ENOG4105C6T cysteine synthase M654_RS00055 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase M654_RS00060 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) M654_RS00065 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) M654_RS00070 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) M654_RS00075 ENOG4108UGV hypoxanthine phosphoribosyltransferase M654_RS00120 ENOG41060GV RNA binding s1 domain protein M654_RS00135 ENOG4105VYY sporulation protein yabp M654_RS00140 ENOG41082I2 s4 domain protein M654_RS00145 ENOG4108IY2 MazG family M654_RS00155 ENOG4108M14 stage v sporulation protein t M654_RS00160 ENOG4108JA2 transcriptioN-repair coupling factor M654_RS00175 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) M654_RS00180 ENOG4105C5T Phosphoribosyl pyrophosphate synthase M654_RS00185 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) M654_RS00190 ENOG4105K4W Could be involved in septation (By similarity) M654_RS00195 ENOG4105KME endoribonuclease L-psp M654_RS00200 ENOG4105DFT pur operon repressor M654_RS00205 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) M654_RS00210 ENOG4105XEW small acid-soluble spore protein M654_RS00215 ENOG4105W42 Veg protein M654_RS00220 ENOG4105XFA sporulation peptidase YabG M654_RS00225 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) M654_RS00235 ENOG41069ER domain protein M654_RS00240 ENOG4105F8V Hydrolase, tatD family M654_RS00245 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) M654_RS00250 ENOG4105KRN Transcriptional regulator, abrb family M654_RS00255 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) M654_RS00260 ENOG4105VC4 domain protein M654_RS00265 ENOG41060K3 Methyltransferase M654_RS00270 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) M654_RS00275 ENOG4105MA4 psp1 domain protein M654_RS00280 ENOG4105FA2 dna polymerase iii M654_RS00285 ENOG4105XVJ Protein of unknown function (DUF327) M654_RS00290 ENOG4105X0R protein from nitrogen regulatory protein P-II M654_RS00295 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) M654_RS00300 ENOG4105CXN decarboxylase M654_RS00305 ENOG4105CDW Resistance protein M654_RS00330 ENOG4106DF1 M654_RS00355 ENOG41067KS pro-sigma K processing M654_RS00360 ENOG41067KS pro-sigma K processing M654_RS00370 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) M654_RS00375 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) M654_RS00380 ENOG4105C6E dna polymerase iii M654_RS00390 ENOG4108Z6B deaminase M654_RS00395 ENOG4105GTG Isochorismatase M654_RS00400 ENOG4105VRS hydrolase family 18 M654_RS00410 ENOG4105ZMH deoxynucleoside kinase M654_RS00425 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR M654_RS00430 ENOG4107QQ0 gntp family M654_RS00435 ENOG4105BZW Glycerate kinase M654_RS00440 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) M654_RS00445 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) M654_RS00450 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) M654_RS00460 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) M654_RS00500 ENOG41067KS pro-sigma K processing M654_RS00505 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M654_RS00510 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M654_RS00520 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) M654_RS00525 ENOG410848D S4 domain protein YaaA M654_RS00530 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) M654_RS00535 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) M654_RS00545 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) M654_RS00560 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) M654_RS00565 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) M654_RS00575 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) M654_RS00585 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) M654_RS00590 ENOG4107QJE Chromosome Partitioning Protein M654_RS00595 ENOG4105FA0 parb-like partition protein M654_RS00600 ENOG4108ZDA Sporulation protein YyaC M654_RS00610 ENOG4105VDK protein, conserved in bacteria M654_RS00615 ENOG4105C3G gtp-binding protein M654_RS00620 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) M654_RS00625 ENOG4108UUM single-stranded DNA-binding protein M654_RS00630 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) M654_RS00635 ENOG4108C33 Resolvase M654_RS00640 ENOG4105CHH sulfate transporter M654_RS00645 ENOG4107YZX Universal stress protein M654_RS00660 ENOG4105CHH sulfate transporter M654_RS00665 ENOG4107YZX Universal stress protein M654_RS00675 ENOG4108XMW Membrane M654_RS00680 ENOG4105BZR domain protein M654_RS00685 ENOG4105K9Q Binds to the 23S rRNA (By similarity) M654_RS00695 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate M654_RS00705 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) M654_RS00710 ENOG4105CE4 GlcNAc 6-P deacetylase M654_RS00720 ENOG4105DJ2 Major Facilitator Superfamily M654_RS00730 ENOG4105CDU Replicative dna helicase M654_RS00735 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis M654_RS00740 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) M654_RS00765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_RS00770 ENOG4105BZU Histidine kinase M654_RS00785 ENOG4105Q2H domain protein M654_RS00790 ENOG4105C0H protease M654_RS00805 ENOG4105WQG acetyltransferase M654_RS00820 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) M654_RS00855 ENOG4105VUF Transcriptional regulator M654_RS00880 ENOG4105BZU Histidine kinase M654_RS00885 ENOG4105KCT ABC transporter M654_RS00890 ENOG4108M15 ABC transporter M654_RS00905 ENOG4105EHG Permease protein M654_RS00910 ENOG4105DQ5 transport system permease protein M654_RS00930 ENOG4108JU3 Alkyl hydroperoxide reductase M654_RS00935 ENOG4105D3R alkyl hydroperoxide reductase M654_RS00940 ENOG4107R4J Chloride channel M654_RS00950 ENOG4105C0A alcohol dehydrogenase M654_RS00965 ENOG4105CMG Carbohydrate kinase M654_RS00980 ENOG41082J7 Rhodanese domain protein M654_RS00985 ENOG4105RV9 Transcriptional regulator M654_RS00990 ENOG4105E2R ROK family M654_RS00995 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase M654_RS01000 ENOG4105CMR udp-glucose 4-epimerase M654_RS01005 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) M654_RS01015 ENOG4107FKK extracellular solute-binding protein family 1 M654_RS01025 ENOG4105EG2 ABC transporter, permease M654_RS01050 ENOG4105DCF alanine dehydrogenase M654_RS01055 ENOG4105BZG amino acid carrier protein M654_RS01060 ENOG4105EC8 Methyl-accepting chemotaxis M654_RS01115 ENOG4108V5C ABC transporter M654_RS01125 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) M654_RS01130 ENOG4108MDK Dehydrogenase M654_RS01135 ENOG410667J hydrolase M654_RS01140 ENOG4105C5H ABC transporter M654_RS01145 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) M654_RS01155 ENOG4105CXY transporter M654_RS01160 ENOG4107VXM glycerophosphoryl diester phosphodiesterase M654_RS01165 ENOG4105CPC Aldo Keto reductase M654_RS01175 ENOG4105C26 Dehydrogenase M654_RS01180 ENOG4105DH8 myo-inositol catabolism M654_RS01185 ENOG4105D7K pfkb domain protein M654_RS01190 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) M654_RS01195 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) M654_RS01205 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) M654_RS01210 ENOG4105F0H myo-inositol catabolism protein M654_RS01215 ENOG4107TRN Xylose isomerase domain protein TIM barrel M654_RS01220 ENOG4105D2N Aldolase M654_RS01225 ENOG4108594 Permease of the drug metabolite transporter M654_RS01230 ENOG4105CPF Cell wall formation (By similarity) M654_RS01245 ENOG4105JKW Valine--pyruvate aminotransferase M654_RS01255 ENOG4107R8N Glycosyl transferase, family 2 M654_RS01260 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) M654_RS01290 ENOG4107RHR regulatoR M654_RS01295 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) M654_RS01300 ENOG4105D9N nucleoside M654_RS01305 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) M654_RS01320 ENOG4105C1J atp-dependent rna helicase M654_RS01325 ENOG4106Z5D Glycoside Hydrolase Family 43 M654_RS01335 ENOG4107QHE Choloylglycine hydrolase M654_RS01355 ENOG4105C5Y PTS System M654_RS01360 ENOG4105CS2 ec 3.2.1.21 M654_RS01370 ENOG4105EWM Histidine kinase M654_RS01375 ENOG4105C19 ABC transporter M654_RS01385 ENOG4105EDW glycosyl transferase, family 39 M654_RS01395 ENOG4107QP3 malate synthase g M654_RS01405 ENOG4105ETU transcriptional activator (TenA M654_RS01410 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein M654_RS01415 ENOG4108JJB ABC transporter M654_RS01420 ENOG4108W7F transporter, permease M654_RS01425 ENOG4105CID antiterminator M654_RS01430 ENOG4105C5Y PTS System M654_RS01435 ENOG4105CS2 ec 3.2.1.21 M654_RS01445 ENOG4105CH6 catalase M654_RS01455 ENOG4105VZ8 Transcriptional regulator M654_RS01485 ENOG4105CMR udp-glucose 4-epimerase M654_RS01490 ENOG4105CKK Glycosyl transferase, family 2 M654_RS01495 ENOG4105EDW glycosyl transferase, family 39 M654_RS01515 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) M654_RS01520 ENOG4105DT3 PTS system, galactitol-specific IIc component M654_RS01530 ENOG4105FB2 class II Aldolase M654_RS01550 ENOG4105ETE Transcriptional regulator (LacI family M654_RS01560 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component M654_RS01565 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M654_RS01570 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) M654_RS01575 ENOG4107R3K hydrolase M654_RS01580 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) M654_RS01590 ENOG4105JVQ RNA Polymerase M654_RS01600 ENOG4105CK1 PTS System M654_RS01605 ENOG4105CS2 ec 3.2.1.21 M654_RS01610 ENOG4108FPN Integrase M654_RS01610 ENOG4108FPN Integrase M654_RS01630 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_RS01655 ENOG4105C5B carbamate kinase M654_RS01665 ENOG4105DBV ornithine carbamoyltransferase M654_RS01670 ENOG4105CEU Arginine dihydrolase M654_RS01675 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) M654_RS01680 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) M654_RS01710 ENOG4105E0M Sulfatase M654_RS01735 ENOG4105X3H Excalibur domain protein M654_RS01740 ENOG4108QXE glycerophosphoryl diester phosphodiesterase M654_RS01745 ENOG4105D2K citrate carrier protein M654_RS01750 ENOG4107QZ7 Cellulose synthase catalytic subunit M654_RS01760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M654_RS01765 ENOG4107BJW polysaccharide deacetylase M654_RS01775 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) M654_RS01780 ENOG4108IMY Transcriptional regulator M654_RS01785 ENOG4105HDK L-asparaginase M654_RS01790 ENOG4108IJ0 Aspartate ammonia-lyase M654_RS01795 ENOG4105DFD Na H antiporter M654_RS01810 ENOG4108QTI )-transporter M654_RS01820 ENOG4105C4M (Ubiquinol oxidase) subunit I M654_RS01825 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii M654_RS01830 ENOG4108JJ9 ABC, transporter M654_RS01835 ENOG4108JJ8 (ABC) transporter M654_RS01845 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) M654_RS01855 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) M654_RS01870 ENOG4105CH6 catalase M654_RS01900 ENOG4105DA5 (ABC) transporter M654_RS01910 ENOG4105C2C drug resistance transporter, Bcr CflA M654_RS01925 ENOG4107TDE lipolytic protein G-D-S-L family M654_RS01930 ENOG4105BZ1 (ABC) transporter M654_RS01935 ENOG4105VUN Transcriptional regulator M654_RS01945 ENOG4105CR4 methylisocitrate lyase M654_RS01950 ENOG4105DXD 2-methylcitrate dehydratase M654_RS01970 ENOG4105C5E polysaccharide biosynthesis protein M654_RS01975 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase M654_RS01980 ENOG4108VX5 3-methyladenine DNA glycosylase M654_RS01985 ENOG4105EMD TRANSCRIPTIONal M654_RS01990 ENOG4105VZJ PTS System M654_RS01995 ENOG4105CK1 PTS System M654_RS02000 ENOG4105VCP PTS System M654_RS02005 ENOG4105F8D glycoside hydrolase family 4 M654_RS02015 ENOG4105CM2 brancheD-chain amino acid aminotransferase M654_RS02020 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD M654_RS02025 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) M654_RS02030 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein M654_RS02035 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) M654_RS02050 ENOG4105D3W isochorismatase M654_RS02055 ENOG41080V3 Major Facilitator superfamily M654_RS02065 ENOG4105IIU Aminopeptidase M654_RS02070 ENOG4105J4Q Transcriptional regulator M654_RS02075 ENOG4105D7K pfkb domain protein M654_RS02080 ENOG4108UHU Aldolase M654_RS02085 ENOG4105CXK mandelate racemase muconate lactonizing M654_RS02090 ENOG4105DJB Major Facilitator Superfamily M654_RS02100 ENOG4105EYF MMPL domain protein M654_RS02105 ENOG4108VB1 regulatoR M654_RS02110 ENOG4105ENE Histidine kinase M654_RS02125 ENOG4105X1N Glycosyl transferase family 8 M654_RS02130 ENOG4105C5I Dehydrogenase M654_RS02140 ENOG4105DR4 Methyltransferase M654_RS02145 ENOG4105CK7 Sodium proline symporter M654_RS02150 ENOG41067MG lrgb family M654_RS02170 ENOG4105CMU LysR family (Transcriptional regulator M654_RS02175 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase M654_RS02180 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) M654_RS02190 ENOG4105C93 Xylose Isomerase M654_RS02195 ENOG4105CMG Carbohydrate kinase M654_RS02210 ENOG4108WS4 fmn reductase M654_RS02220 ENOG4105CMR udp-glucose 4-epimerase M654_RS02225 ENOG4105E2S oxidase) subunit II M654_RS02230 ENOG4105BZ9 Cytochrome C oxidase, subunit I M654_RS02240 ENOG41060D1 Quinol oxidase M654_RS02255 ENOG4105DWD nucleoside recognition domain protein M654_RS02270 ENOG4108DBC nitroreductase M654_RS02275 ENOG4105DEN Luciferase family M654_RS02285 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin M654_RS02300 ENOG4105C5Y PTS System M654_RS02315 ENOG4105DWF phosphomethylpyrimidine kinase M654_RS02320 ENOG4105H67 Protein of unknown function (DUF421) M654_RS02325 ENOG4108RJ9 Glycosyl transferase, family 2 M654_RS02330 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) M654_RS02350 ENOG4105WH1 Two component transcriptional regulator luxr family M654_RS02360 ENOG4105CJ1 ABC, transporter M654_RS02380 ENOG4105CZN Potassium uptake protein M654_RS02390 ENOG4107JTW chlorite dismutase M654_RS02395 ENOG4108IJ2 phosphate acetyltransferase M654_RS02405 ENOG4105J4Q Transcriptional regulator M654_RS02430 ENOG4105D2S major facilitator superfamily M654_RS02440 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) M654_RS02450 ENOG4108VCI transcription factor, rsfa family M654_RS02460 ENOG4105DCI Phosphohydrolase M654_RS02475 ENOG41069HH 4-oxalocrotonate tautomerase M654_RS02480 ENOG4108Z4T Peptidase M50 M654_RS02485 ENOG4108XFG YwhD family M654_RS02490 ENOG4105BZ4 penicillin-binding protein M654_RS02500 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) M654_RS02505 ENOG4105CYW agmatinase M654_RS02510 ENOG410684U Domain of unknown function (DUF1934) M654_RS02515 ENOG4105C75 arginyL-tRNA synthetase M654_RS02530 ENOG4105DF6 Fe-S oxidoreductase M654_RS02540 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase M654_RS02545 ENOG4105C1G acyl-Coa dehydrogenase M654_RS02550 ENOG4105C1G acyl-Coa dehydrogenase M654_RS02560 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) M654_RS02570 ENOG410812K response regulator receiver protein M654_RS02575 ENOG4105D2N Aldolase M654_RS02580 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway M654_RS02585 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) M654_RS02590 ENOG4105CBT Fructose-1,6-bisphosphatase M654_RS02595 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) M654_RS02600 ENOG41082DI 50s ribosomal protein l31 M654_RS02605 ENOG4107104 thymidine kinase M654_RS02610 ENOG4105C6K Malic enzyme M654_RS02615 ENOG4107TT2 Auxin Efflux Carrier M654_RS02625 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase M654_RS02630 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) M654_RS02635 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) M654_RS02640 ENOG4108ZXQ stage ii sporulation protein r M654_RS02650 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) M654_RS02655 ENOG410815N Probably functions as a manganese efflux pump (By similarity) M654_RS02660 ENOG4107WAU Protein tyrosine phosphatase M654_RS02665 ENOG4108YZG isomerase M654_RS02670 ENOG4108UIC UPF0340 protein M654_RS02675 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) M654_RS02680 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) M654_RS02690 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) M654_RS02705 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) M654_RS02710 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) M654_RS02715 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) M654_RS02720 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) M654_RS02725 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) M654_RS02730 ENOG4106778 Protein of unknown function (DUF1146) M654_RS02740 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) M654_RS02755 ENOG4108TF4 von Willebrand factor, type A M654_RS02770 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) M654_RS02775 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) M654_RS02790 ENOG4108Z40 Transcriptional regulator M654_RS02795 ENOG4108RYK Nad-dependent epimerase dehydratase M654_RS02800 ENOG4106BRK M654_RS02805 ENOG410874W AraC family transcriptional regulator M654_RS02825 ENOG4105NIV Esterase M654_RS02830 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase M654_RS02835 ENOG4105E4F Isochorismate synthase M654_RS02840 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase M654_RS02845 ENOG4105WQI isochorismatase M654_RS02850 ENOG4105CEY Amp-dependent synthetase and ligase M654_RS02855 ENOG4105WQT MbtH domain protein M654_RS02860 ENOG4105C0R drug resistance transporter emrb qaca subfamily M654_RS02865 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) M654_RS02875 ENOG4107TCE N-acetyltransferase M654_RS02880 ENOG4105FRN stage II sporulation protein M654_RS02885 ENOG4108KPJ rna polymerase sigma factor M654_RS02900 ENOG4105BZU Histidine kinase M654_RS02905 ENOG4105C37 (CBS) domain M654_RS02915 ENOG41080XP Cbs domain M654_RS02920 ENOG4108NA0 Uncharacterized conserved protein (COG2071) M654_RS02930 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase M654_RS02935 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase M654_RS02945 ENOG4105CZM Major Facilitator M654_RS02950 ENOG4107MII Sugar-specific transcriptional regulator TrmB M654_RS02960 ENOG4105MT0 Sporulation transcriptional regulator spoiiid M654_RS02965 ENOG4105DFF Rod shape-determining protein mreb M654_RS02975 ENOG4105CGA flagellar basal-body rod protein FlgG M654_RS02980 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) M654_RS03000 ENOG4105Z8H single-stranded DNA-binding protein M654_RS03005 ENOG4105DKT Transcriptional regulator M654_RS03015 ENOG410787A Pts system, glucitol sorbitol-specific M654_RS03020 ENOG4105DZY Pts system, glucitol sorbitol-specific M654_RS03030 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase M654_RS03040 ENOG4105E98 transcriptional regulator DeoR family M654_RS03045 ENOG410667J hydrolase M654_RS03050 ENOG4108XI2 Domain of unknown function (DUF1963) M654_RS03055 ENOG4105C0D helicase M654_RS03060 ENOG4105KBK Zinc finger, swim domain protein M654_RS03070 ENOG4105HTX biosynthesis protein M654_RS03075 ENOG4108RB3 Capsular polysaccharide biosynthesis protein M654_RS03080 ENOG4105C6Y Udp-glucose 6-dehydrogenase M654_RS03085 ENOG4105FGV Chromate M654_RS03090 ENOG4105CAH Chromate M654_RS03100 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) M654_RS03105 ENOG4107RSM transcriptional regulator M654_RS03115 ENOG4107FQX Alpha-acetolactate decarboxylase M654_RS03120 ENOG41089UC methyltransferase, type 11 M654_RS03125 ENOG4105C5Q Transcriptional regulator M654_RS03130 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M654_RS03135 ENOG4105CNN ABC, transporter M654_RS03140 ENOG4105C2J ABC transporter M654_RS03145 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) M654_RS03150 ENOG4108RVA ribokinase M654_RS03155 ENOG4105ETE Transcriptional regulator (LacI family M654_RS03160 ENOG4105N98 Capsule biosynthesis protein capB M654_RS03170 ENOG4105PNM synthesis protein M654_RS03175 ENOG4105K4H Nlp p60 protein M654_RS03180 ENOG4105J7I hydrolase M654_RS03185 ENOG4108KGH TRANSCRIPTIONal M654_RS03190 ENOG4105C54 Major Facilitator superfamily M654_RS03195 ENOG4105E2A Dehydrogenase M654_RS03200 ENOG4105CHR reductase M654_RS03210 ENOG4108M60 Transcriptional regulator M654_RS03215 ENOG4105D7K pfkb domain protein M654_RS03220 ENOG4108UHU Aldolase M654_RS03225 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) M654_RS03230 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase M654_RS03240 ENOG4105DG6 mannose-6-phosphate isomerase M654_RS03255 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) M654_RS03265 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase M654_RS03290 ENOG4105EY8 ABC transporter M654_RS03300 ENOG4107SJB teichoic acid biosynthesis M654_RS03305 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) M654_RS03310 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase M654_RS03320 ENOG4107RZX Teichoic acid biosynthesis protein M654_RS03325 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase M654_RS03330 ENOG4108KGH TRANSCRIPTIONal M654_RS03340 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M654_RS03345 ENOG4105D3Q Sugar transferase M654_RS03350 ENOG4105PSV Polysaccharide Biosynthesis Protein M654_RS03355 ENOG4107RA4 Glycosyl transferase (Group 1 M654_RS03360 ENOG4105C6Y Udp-glucose 6-dehydrogenase M654_RS03365 ENOG4105C1B dTDP-glucose 4-6-dehydratase M654_RS03370 ENOG4105QZI O-Antigen Polymerase M654_RS03385 ENOG4107EF8 Glycosyl transferase (Group 1 M654_RS03390 ENOG4105ESV Glycosyl transferase, family 4 M654_RS03395 ENOG4108J53 cell adhesion domain-containing protein M654_RS03400 ENOG4108KGH TRANSCRIPTIONal M654_RS03405 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein M654_RS03410 ENOG4105BZU Histidine kinase M654_RS03415 ENOG4105WH1 Two component transcriptional regulator luxr family M654_RS03435 ENOG41081UC Inherit from COG: Competence protein M654_RS03440 ENOG4105RU3 M654_RS03455 ENOG4105E1Q flagellar hook-associated protein M654_RS03460 ENOG4105DTJ flagellar hook-associated protein M654_RS03465 ENOG4105MKD M654_RS03470 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) M654_RS03475 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) M654_RS03480 ENOG4105I03 Flagellin M654_RS03490 ENOG41083S7 flagellar protein FlaG M654_RS03495 ENOG4107RT6 flagellar hook-associated M654_RS03500 ENOG4105MQ3 flagellar protein FliS M654_RS03515 ENOG4105MS2 ribosomal subunit Interface protein M654_RS03520 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving M654_RS03540 ENOG4105CAK Cell division ATP-binding protein ftsE M654_RS03545 ENOG4105CRP Part of the ABC transporter FtsEX involved in M654_RS03555 ENOG4105DY9 regulatoR M654_RS03570 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) M654_RS03575 ENOG4105CN1 protease M654_RS03600 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) M654_RS03605 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) M654_RS03620 ENOG4108PY7 M654_RS03625 ENOG41067S9 phage shock protein C, PspC M654_RS03630 ENOG41086DT Membrane protein of unknown function M654_RS03635 ENOG41088CQ domain protein M654_RS03640 ENOG4105C0R drug resistance transporter emrb qaca subfamily M654_RS03645 ENOG410834F Transcriptional regulator M654_RS03650 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) M654_RS03660 ENOG4105HKU nucleoside recognition domain-containing protein M654_RS03665 ENOG4107XGZ Hydrolase M654_RS03670 ENOG4108S4C acetyltransferase M654_RS03675 ENOG4105VRS hydrolase family 18 M654_RS03685 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) M654_RS03690 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) M654_RS03695 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) M654_RS03700 ENOG4105ECC imidazole-glycerol-phosphate dehydratase M654_RS03705 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) M654_RS03710 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase M654_RS03715 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) M654_RS03720 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase M654_RS03735 ENOG4105C3M thioredoxin reductase M654_RS03740 ENOG4108Z4K mutator MutT protein M654_RS03745 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) M654_RS03750 ENOG4105CHW UPF0052 protein M654_RS03755 ENOG4105CIE May be required for sporulation (By similarity) M654_RS03760 ENOG4105KRI phosphocarrier protein (HPr M654_RS03765 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase M654_RS03770 ENOG4105KVH Transcriptional regulator M654_RS03775 ENOG4108VA3 3-hexulose-6-phosphate synthase M654_RS03780 ENOG41080HJ 6-phospho 3-hexuloisomerase M654_RS03785 ENOG4108ZHR arsR family transcriptional regulator M654_RS03790 ENOG4108SQ9 flavin reductase domain protein, FMN-binding M654_RS03795 ENOG4105C5I Dehydrogenase M654_RS03800 ENOG4108V2W Carbonate dehydratase M654_RS03805 ENOG4105CHH sulfate transporter M654_RS03810 ENOG4107TVP HD domain protein M654_RS03815 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain M654_RS03820 ENOG4108URH decarboxylase M654_RS03825 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) M654_RS03850 ENOG4108HKT sucrose-6-phosphate hydrolase M654_RS03855 ENOG4105EDQ levansucrase EC 2.4.1.10 M654_RS03860 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M654_RS03870 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein M654_RS03880 ENOG4105HTX biosynthesis protein M654_RS03885 ENOG4108QV3 biosynthesis protein M654_RS03895 ENOG4108PQP glycosyl transferase group 1 M654_RS03900 ENOG4105K64 Glycosyl transferase, family 2 M654_RS03905 ENOG4108KMV Glycosyl transferase (Group 1 M654_RS03910 ENOG41068W6 Capsular polysaccharide biosynthesis protein M654_RS03915 ENOG4107QRS glycosyltransferase group 2 family protein M654_RS03925 ENOG4105K64 Glycosyl transferase, family 2 M654_RS03935 ENOG4105D3Q Sugar transferase M654_RS03940 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family M654_RS03945 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase M654_RS03950 ENOG4108ZPC Polysaccharide pyruvyl transferase M654_RS03960 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_RS03965 ENOG4105DAA L-lactate M654_RS03970 ENOG4105JXH GntR family transcriptional regulator M654_RS03975 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) M654_RS04010 ENOG4108WAV Transcriptional regulator M654_RS04015 ENOG4105KIS phospholipid-binding protein M654_RS04040 ENOG4105DEN Luciferase family M654_RS04055 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase M654_RS04060 ENOG4105BZA Phosphoglycerate kinase M654_RS04065 ENOG4105CP7 Triose-phosphate isomerase M654_RS04070 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) M654_RS04075 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) M654_RS04080 ENOG4108V4B ThiJ pfpI M654_RS04090 ENOG4105C8Q Methyl-accepting chemotaxis M654_RS04095 ENOG4108MES Periplasmic binding protein M654_RS04100 ENOG4105T65 Membrane-associated protein M654_RS04110 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein M654_RS04115 ENOG4107HG4 Transcriptional regulator M654_RS04120 ENOG4108IJ8 ABC transporter M654_RS04125 ENOG4105E90 ABC transporter M654_RS04130 ENOG4108HQR Glycine betaine M654_RS04135 ENOG4105R40 Glycine betaine carnitine choline M654_RS04160 ENOG4105XZU Preprotein translocase, subunit SecG M654_RS04170 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) M654_RS04175 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) M654_RS04190 ENOG4107SYN Glycosyl hydrolases family 43 M654_RS04195 ENOG4108MYR Secreted protein M654_RS04220 ENOG4105F0F Oxalate decarboxylase M654_RS04230 ENOG4106DF4 Sigma-70, region 4 M654_RS04240 ENOG4105C72 UPF0176 protein M654_RS04255 ENOG4105D9R oxidoreductase M654_RS04265 ENOG41086NF K02433 aspartyl-tRNA(Asn) glutamyl-tRNA (Gln) amidotransferase subunit A EC 6.3.5.6 6.3.5.7 M654_RS04280 ENOG4106A3M Cytochrome p-450 M654_RS04285 ENOG410625E M654_RS04315 ENOG4105C9F isomerase M654_RS04320 ENOG4105DET Rhamnulokinase M654_RS04325 ENOG4105E98 transcriptional regulator DeoR family M654_RS04330 ENOG4107RKG DJ-1/PfpI family M654_RS04335 ENOG4105VPX protein, conserved in bacteria M654_RS04340 ENOG410681U heavy metal transport detoxification protein M654_RS04345 ENOG4105C59 p-type ATPase M654_RS04350 ENOG4105DSE periplasmic solute binding protein M654_RS04355 ENOG4105CC5 ABC transporter M654_RS04360 ENOG4105DIK (ABC) transporter M654_RS04370 ENOG4105CJQ hydrolase, family 31 M654_RS04375 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component M654_RS04385 ENOG4108JE9 extracellular solute-binding protein family 1 M654_RS04390 ENOG4105C59 p-type ATPase M654_RS04395 ENOG4107ZQN disulfide bond M654_RS04420 ENOG4108MTT Glutamate-rich protein grpB M654_RS04425 ENOG4105EN6 Membrane M654_RS04435 ENOG4105EEM helicase M654_RS04445 ENOG4107EPV Aminotransferase class V M654_RS04450 ENOG4105EEQ Na H antiporter M654_RS04455 ENOG4105EVU fructokinase M654_RS04470 ENOG4107QZ2 Sulfatase M654_RS04485 ENOG4105D5Q Arginine ornithine antiporter M654_RS04490 ENOG4105DQ5 transport system permease protein M654_RS04495 ENOG4105EHG Permease protein M654_RS04500 ENOG4105E0A ABC, transporter M654_RS04505 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_RS04515 ENOG4105D2H Uronic isomerase M654_RS04520 ENOG4105CT4 transporter M654_RS04525 ENOG4107KJX Transcriptional regulator M654_RS04530 ENOG4107QZW Altronate oxidoreductase M654_RS04535 ENOG4105CTX dehydratase M654_RS04545 ENOG4105C5Q Transcriptional regulator M654_RS04550 ENOG4108RPX mosc domain containing protein M654_RS04555 ENOG4105EWI Short-chain dehydrogenase reductase Sdr M654_RS04560 ENOG4105DRR Transcriptional regulator, GntR family M654_RS04565 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) M654_RS04570 ENOG4105EHG Permease protein M654_RS04575 ENOG4105E0A ABC, transporter M654_RS04580 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) M654_RS04585 ENOG4105C0A alcohol dehydrogenase M654_RS04605 ENOG4105G63 Type III effector Hrp-dependent M654_RS04610 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) M654_RS04615 ENOG4105CHR reductase M654_RS04620 ENOG4108WBT adenosyltransferase M654_RS04625 ENOG4105NBR Pectinesterase M654_RS04635 ENOG41087YS Phage shock protein A M654_RS04650 ENOG4105ENE Histidine kinase M654_RS04655 ENOG4105WH1 Two component transcriptional regulator luxr family M654_RS04685 ENOG4105C9Q fumarate hydratase class II M654_RS04690 ENOG41067SE Tetr family transcriptional regulator M654_RS04695 ENOG4105F3H Histidine kinase M654_RS04705 ENOG4105C0H protease M654_RS04710 ENOG4105HUF DNA protection during starvation protein M654_RS04715 ENOG4105E1F short-chain dehydrogenase reductase M654_RS04720 ENOG4105DZ1 carboxypeptidase M654_RS04735 ENOG4108MES Periplasmic binding protein M654_RS04740 ENOG4105DQ5 transport system permease protein M654_RS04745 ENOG4108IHU transport system permease protein M654_RS04750 ENOG4105E0A ABC, transporter M654_RS04785 ENOG4105CHU acetyl-coa acetyltransferase M654_RS04790 ENOG4105C1G acyl-Coa dehydrogenase M654_RS04795 ENOG41080E8 Transcriptional regulator, Spx MgsR family M654_RS04800 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) M654_RS04825 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) M654_RS04830 ENOG4108UMI ABC transporter, permease M654_RS04835 ENOG4105D01 (LipO)protein M654_RS04845 ENOG4105PGM cation diffusion facilitator family transporter M654_RS04850 ENOG4105C3K feS assembly ATPase SufC M654_RS04855 ENOG4105JRK feS assembly protein SufD M654_RS04860 ENOG4105C9B Cysteine desulfurase M654_RS04865 ENOG4108UNV SUF system FeS assembly protein, NifU family M654_RS04870 ENOG4105DIW FeS assembly protein SUFB M654_RS04890 ENOG4107VFR oxidoreductase M654_RS04905 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine M654_RS04910 ENOG4105XN3 extracellular solute-binding protein family 1 M654_RS04915 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component M654_RS04920 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component M654_RS04925 ENOG4108KPW sugar kinase M654_RS04930 ENOG4105FDP GntR family transcriptional regulator M654_RS04935 ENOG4108K8S endonuclease I M654_RS04955 ENOG4105G9B Transcriptional regulator M654_RS04965 ENOG4105C5R Aminotransferase M654_RS04970 ENOG4105CD3 dihydroorotase M654_RS04975 ENOG4105W1N transcriptional regulator M654_RS04980 ENOG4105IIP Membrane M654_RS04985 ENOG4105I3N Conserved Protein M654_RS04995 ENOG4107R8B 5'-nucleotidase M654_RS05000 ENOG4105KZD Domain of unknown function (DUF1805) M654_RS05005 ENOG4108YTE sporulation protein YunB M654_RS05010 ENOG4105C8J )-transporter M654_RS05020 ENOG4105FAA peptidase M23 M654_RS05025 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) M654_RS05030 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) M654_RS05035 ENOG4105MMD transcriptional regulator M654_RS05045 ENOG4105D4U had-superfamily hydrolase, subfamily iia M654_RS05060 ENOG4108W5N phosphatidylglycerophosphatase a M654_RS05070 ENOG4105C5I Dehydrogenase M654_RS05075 ENOG4105D6E homoserine dehydrogenase M654_RS05080 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) M654_RS05085 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) M654_RS05090 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein M654_RS05095 ENOG41083MR nifu domain-containing protein M654_RS05110 ENOG4105PY6 Phenolic acid decarboxylase M654_RS05150 ENOG4108YX9 iron--sulfur cluster insertion protein erpA M654_RS05155 ENOG4108YM7 Gcn5-related n-acetyltransferase M654_RS05170 ENOG4105CAY ferredoxin--nadp reductase M654_RS05175 ENOG4105CEP NADH dehydrogenase M654_RS05190 ENOG41069ER domain protein M654_RS05200 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) M654_RS05220 ENOG4105DCF alanine dehydrogenase M654_RS05225 ENOG4108K8K Transcriptional regulator M654_RS05230 ENOG4105BZG amino acid carrier protein M654_RS05265 ENOG410904N short-chain dehydrogenase reductase M654_RS05280 ENOG4105C02 permease M654_RS05305 ENOG4105DAP Nicotinate phosphoribosyltransferase M654_RS05310 ENOG4105D58 Diguanylate phosphodiesterase M654_RS05335 ENOG4105BZU Histidine kinase M654_RS05345 ENOG4105KA0 thioesterase Superfamily protein M654_RS05350 ENOG4105KJM monovalent cation h antiporter subunit g M654_RS05360 ENOG4105SC1 monovalent cation H antiporter subunit E M654_RS05365 ENOG4108JPZ Monovalent cation H antiporter subunit D M654_RS05370 ENOG4108ZE9 Monovalent cation H antiporter subunit C M654_RS05375 ENOG4105HC0 Na H antiporter M654_RS05380 ENOG4105D65 subunit l M654_RS05395 ENOG4105DJ4 phosphatidylserine decarboxylase M654_RS05400 ENOG4107ZTW SNARE associated Golgi M654_RS05405 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase M654_RS05410 ENOG4108MRH transcriptional regulatory protein M654_RS05425 ENOG4105KIR Thiol-disulfide oxidoreductase dcc M654_RS05430 ENOG4105BZ4 penicillin-binding protein M654_RS05445 ENOG4105Y38 Kinase-associated protein B M654_RS05455 ENOG4105C87 Aminotransferase class I and II M654_RS05470 ENOG4108MUZ hydrolase M654_RS05475 ENOG4108ZB6 transcriptional regulator AsnC family M654_RS05480 ENOG4105CHM Aminotransferase M654_RS05490 ENOG4105WG9 Conserved Protein M654_RS05495 ENOG4107QW4 alcohol dehydrogenase M654_RS05500 ENOG4107QYV phosphohexose isomerase M654_RS05505 ENOG41068WN M654_RS05515 ENOG410900G Protein of unknown function (DUF421) M654_RS05525 ENOG4107PBV potassium channel M654_RS05530 ENOG4107PBV potassium channel M654_RS05545 ENOG4105C37 (CBS) domain M654_RS05560 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme M654_RS05565 ENOG4105EA8 2-Nitropropane dioxygenase M654_RS05575 ENOG4105C8Q Methyl-accepting chemotaxis M654_RS05580 ENOG4105C8Q Methyl-accepting chemotaxis M654_RS05585 ENOG4105C8Q Methyl-accepting chemotaxis M654_RS05590 ENOG4108Z0Z intracellular protease Pfpi family M654_RS05595 ENOG4105EE0 oxidoreductase M654_RS05605 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) M654_RS05635 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) M654_RS05685 ENOG41065RQ ADP-ribosylation crystallin J1 M654_RS05695 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) M654_RS05825 ENOG4105C2M dna polymerase I M654_RS05880 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) M654_RS05885 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M654_RS05910 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) M654_RS05920 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) M654_RS05995 ENOG4108J9Q DNA ligase M654_RS06150 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase M654_RS06200 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily M654_RS06225 ENOG41090VF Stage v sporulation protein ac M654_RS06230 ENOG4105CZ3 stage V sporulation protein ad M654_RS06245 ENOG4108QY0 Membrane M654_RS06250 ENOG4105H67 Protein of unknown function (DUF421) M654_RS06255 ENOG41073R8 VanW family M654_RS06260 ENOG4105JQZ Methyltransferase M654_RS06270 ENOG4105TRT Transcriptional regulator M654_RS06280 ENOG4108JB8 alcohol dehydrogenase M654_RS06285 ENOG4108VNY MOSC domain protein M654_RS06290 ENOG4106DF1 M654_RS06300 ENOG4105CZN Potassium uptake protein M654_RS06310 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) M654_RS06335 ENOG4105N67 Proton-coupled thiamine transporter YuaJ M654_RS06340 ENOG4105CMD Transcriptional regulator, GntR family M654_RS06345 ENOG41067KS pro-sigma K processing M654_RS06505 ENOG4105CIG ABC transporter M654_RS06510 ENOG4105DIM ABC transporter M654_RS06515 ENOG4105KAF membrAne M654_RS06530 ENOG4105FF2 Type I DHQase M654_RS06535 ENOG4108N23 SpoOM-related protein M654_RS06540 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) M654_RS06545 ENOG4105D7T ABC transporter M654_RS06550 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein M654_RS06555 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component M654_RS06560 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) M654_RS06565 ENOG4107D63 M654_RS06570 ENOG4105VZ8 Transcriptional regulator M654_RS06580 ENOG4105DA5 (ABC) transporter M654_RS06600 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) M654_RS06615 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) M654_RS06625 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) M654_RS06645 ENOG4105CYN Serine protein kinase M654_RS06650 ENOG4106AKX UPF0229 protein M654_RS06655 ENOG4105CW7 secretion protein, HlyD family M654_RS06660 ENOG4105C0R drug resistance transporter emrb qaca subfamily M654_RS06665 ENOG4105CS1 NAD(P)H quinone oxidoreductase M654_RS06680 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family M654_RS06685 ENOG4105CZV ABC transporter M654_RS06690 ENOG4105CJ1 ABC, transporter M654_RS06695 ENOG4108TU7 Inherit from COG: (ABC) transporter M654_RS06700 ENOG4105VEQ Cold shock protein M654_RS06705 ENOG4107R6U sodium dicarboxylate symporter M654_RS06740 ENOG4105BZU Histidine kinase M654_RS06760 ENOG41080HJ 6-phospho 3-hexuloisomerase M654_RS06765 ENOG4108VA3 3-hexulose-6-phosphate synthase M654_RS06775 ENOG4105F76 Sarcosine oxidase M654_RS06780 ENOG4105DVW rieske (2Fe-2S) M654_RS06785 ENOG4108IJ7 Glycine betaine M654_RS06810 ENOG4105KVH Transcriptional regulator M654_RS06815 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase M654_RS06830 ENOG4108YBP pseudouridine synthase M654_RS06840 ENOG41080XP Cbs domain M654_RS06845 ENOG4107YBY Hydrolase M654_RS06850 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase M654_RS06855 ENOG4105C5H ABC transporter M654_RS06860 ENOG4105RK9 auxin efflux carrier M654_RS06870 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator M654_RS06880 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) M654_RS06885 ENOG4105C6V Glycerol-3-phosphate dehydrogenase M654_RS06905 ENOG4105BZU Histidine kinase M654_RS06910 ENOG4105WH1 Two component transcriptional regulator luxr family M654_RS06930 ENOG4105KPV Transcriptional regulator M654_RS06935 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) M654_RS06940 ENOG4105ED1 spovr family M654_RS06955 ENOG4105BZN citrate synthase M654_RS06960 ENOG4105C8J )-transporter M654_RS06970 ENOG41086D8 Transcriptional regulator M654_RS06975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M654_RS06990 ENOG4105J37 M654_RS06995 ENOG4108AEY RNA polymerase sigma factor M654_RS07005 ENOG4105F6E Acyl-transferase M654_RS07020 ENOG4105KAF membrAne M654_RS07025 ENOG4105C37 (CBS) domain M654_RS07035 ENOG4105C37 (CBS) domain M654_RS07060 ENOG4108QXE glycerophosphoryl diester phosphodiesterase M654_RS07070 ENOG4105D64 Mechanosensitive ion channel M654_RS07075 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) M654_RS07090 ENOG4107VMI polysaccharide deacetylase M654_RS07095 ENOG4105F0I Aminotransferase M654_RS07105 ENOG4108N2V aldose 1-epimerase M654_RS07135 ENOG4105BZ1 (ABC) transporter M654_RS07140 ENOG4105BZ1 (ABC) transporter M654_RS07175 ENOG410839P M654_RS07195 ENOG4106MP8 UPF0754 membrane protein M654_RS07200 ENOG4105WZB UPF0342 protein M654_RS07210 ENOG4105D4P Coproporphyrinogen iii oxidase M654_RS07215 ENOG4105CGU Enoyl-CoA hydratase M654_RS07235 ENOG4108IUX (ABC) transporter M654_RS07240 ENOG4105RHA ABC transporter, permease M654_RS07245 ENOG4107VRP DNA repair exonuclease M654_RS07250 ENOG4106D4I domain protein M654_RS07255 ENOG4105EQI Metal Dependent Phosphohydrolase M654_RS07265 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) M654_RS07310 ENOG4105NBU tryptophan transport protein M654_RS07315 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) M654_RS07320 ENOG4105K59 histidine triad (HIT) protein M654_RS07350 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation M654_RS07355 ENOG4105BZ4 penicillin-binding protein M654_RS07360 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) M654_RS07365 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) M654_RS07370 ENOG4105C1Q protoporphyrinogen oxidase M654_RS07380 ENOG4105ECB domain protein M654_RS07390 ENOG4105DER m42 family M654_RS07405 ENOG4106AXD M654_RS07410 ENOG4108RQ5 Beta-lactamase domain-containing protein M654_RS07415 ENOG4105DF9 Lipoate-protein, ligase M654_RS07420 ENOG4105CEY Amp-dependent synthetase and ligase M654_RS07430 ENOG4108JCI Transcriptional regulator M654_RS07445 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 M654_RS07455 ENOG4108UZ3 Transporter M654_RS07460 ENOG4108HUF Transporter M654_RS07465 ENOG4105DQ5 transport system permease protein M654_RS07470 ENOG4108U1V ABC transporter, permease M654_RS07475 ENOG4107TB6 phosphoglycerate mutase M654_RS07485 ENOG4107F3J Amp-dependent synthetase and ligase M654_RS07490 ENOG4107ZYJ bioY protein M654_RS07495 ENOG4106YBV Methyl-accepting chemotaxis M654_RS07515 ENOG4105XVF Competence transcription factor M654_RS07520 ENOG41060YP M654_RS07535 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin M654_RS07540 ENOG410780I phosphoprotein phosphatase activity M654_RS07575 ENOG4108KK1 membrane protein AbrB duplication M654_RS07590 ENOG4105WEF catalase M654_RS07595 ENOG4105CEY Amp-dependent synthetase and ligase M654_RS07600 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) M654_RS07610 ENOG4105BZU Histidine kinase M654_RS07615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_RS07625 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein M654_RS07630 ENOG4105E0C molybdate abc transporter M654_RS07640 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation M654_RS07650 ENOG4105EYH Exonuclease M654_RS07685 ENOG410751J M654_RS07705 ENOG4105ERH Fumarylacetoacetate hydrolase M654_RS07725 ENOG4105CAQ asparagine synthetase M654_RS07735 ENOG4108YZA Nitrogen regulatory protein pii M654_RS07740 ENOG4105UQX Mate efflux family protein M654_RS07745 ENOG4106HBX Transcriptional Regulator AraC Family M654_RS07765 ENOG4105E1K spore germination protein M654_RS07770 ENOG4108ZUB Lysine exporter protein (Lyse ygga) M654_RS07775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M654_RS07785 ENOG4105DY8 decarboxylase M654_RS07810 ENOG4105MA6 gCN5-related N-acetyltransferase M654_RS07815 ENOG4105CHR reductase M654_RS07835 ENOG4108VPT UPF0234 protein M654_RS07840 ENOG4105QNR S1 RNA binding domain protein M654_RS07855 ENOG4105EPR degv family M654_RS07860 ENOG4107AYK membrAne M654_RS07870 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) M654_RS07875 ENOG41073B9 M654_RS07880 ENOG4108KP7 hydrolase M654_RS07885 ENOG4108MXZ Esterase M654_RS07890 ENOG4105VG1 fes assembly suf system protein M654_RS07900 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase M654_RS07905 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) M654_RS07910 ENOG4105CAS nag kinase M654_RS07915 ENOG4105C8Y Acetylornithine aminotransferase M654_RS07920 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain M654_RS07930 ENOG4105DBV ornithine carbamoyltransferase M654_RS07935 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) M654_RS07960 ENOG4107RMD Basic membrane lipoprotein M654_RS07975 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) M654_RS07980 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M654_RS07990 ENOG4105C3U ABC transporter M654_RS07995 ENOG4108JQ7 (ABC) transporter M654_RS08010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_RS08020 ENOG4105C31 Tryptophanyl-tRNA synthetase M654_RS08030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_RS08035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_RS08045 ENOG4108JQ7 (ABC) transporter M654_RS08055 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) M654_RS08060 ENOG4108ZCF integral membrane protein M654_RS08070 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis M654_RS08095 ENOG4108V9W transcriptional regulatory protein M654_RS08100 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism M654_RS08110 ENOG4105DPN Oligoendopeptidase f M654_RS08115 ENOG4105T58 Dithiol-disulfide isomerase M654_RS08120 ENOG4108Z18 K06886 hemoglobin M654_RS08125 ENOG4105E4C Lytic transglycosylase catalytic M654_RS08130 ENOG4105MIX Adenylate cyclase M654_RS08135 ENOG4106EFP UPF0738 protein M654_RS08145 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) M654_RS08150 ENOG4105EMS pseudouridine synthase M654_RS08155 ENOG4107S1Q Phosphatase M654_RS08165 ENOG4105ETU transcriptional activator (TenA M654_RS08170 ENOG4108VEU Thiamine monophosphate synthase M654_RS08185 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) M654_RS08190 ENOG4105D06 uba thif-type nad fad binding protein M654_RS08195 ENOG4105DWF phosphomethylpyrimidine kinase M654_RS08200 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH M654_RS08205 ENOG4107A88 M654_RS08255 ENOG4105ENA helicase M654_RS08265 ENOG4107T5V SNARE associated Golgi M654_RS08270 ENOG4105CMR udp-glucose 4-epimerase M654_RS08275 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase M654_RS08290 ENOG4108ZMI UPF0477 protein M654_RS08315 ENOG4105C28 cystathionine M654_RS08320 ENOG4105C28 cystathionine M654_RS08325 ENOG4105JHY Membrane M654_RS08345 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase M654_RS08360 ENOG4107RV5 Glycosyl hydrolase family 3 N-terminal domain protein M654_RS08375 ENOG4107QRS glycosyltransferase group 2 family protein M654_RS08380 ENOG4105D5D udp-galactopyranose mutase M654_RS08385 ENOG4105DKQ ROK family M654_RS08510 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) M654_RS08530 ENOG4105VZ8 Transcriptional regulator M654_RS08600 ENOG4105CDU Replicative dna helicase M654_RS08615 ENOG4105QBX endodeoxyribonuclease RusA M654_RS08650 ENOG4107JM4 Tetratricopeptide repeat M654_RS08655 ENOG4107EV6 Inherit from COG: YD repeat protein M654_RS08690 ENOG4105IG6 Phage terminase, large subunit M654_RS08700 ENOG4106CGH Phage Mu protein F like protein M654_RS08735 ENOG41060SN M654_RS08750 ENOG4105PQS phage protein M654_RS08755 ENOG4105FR7 XkdM protein, phage-like element PBSX M654_RS08760 ENOG4105MTC XkdN-like protein M654_RS08770 ENOG4108FKH Transglycosylase SLT domain M654_RS08770 ENOG4108FKH Transglycosylase SLT domain M654_RS08775 ENOG4108WZM domain protein M654_RS08780 ENOG4105X7F M654_RS08790 ENOG4105MFU Protein of unknown function (DUF2634) M654_RS08795 ENOG41066EA baseplate J family protein M654_RS08800 ENOG410906S phage-like element pbsx protein xkdt M654_RS08865 ENOG4108UW5 maltose o-acetyltransferase M654_RS08875 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) M654_RS08880 ENOG4105CIB oxidoreductase Domain protein M654_RS08885 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) M654_RS08890 ENOG4105DUM transcriptional regulator, lysR family M654_RS08895 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) M654_RS08900 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) M654_RS08910 ENOG4108Q5Y Membrane M654_RS08915 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase M654_RS08925 ENOG41069ER domain protein M654_RS08935 ENOG4105J7D transcriptional regulator M654_RS08945 ENOG4105K7W phage-related replication protein M654_RS08950 ENOG410635T phage-like element pbsx protein M654_RS08995 ENOG4108TFU terminase (Small subunit) M654_RS09000 ENOG4105IG6 Phage terminase, large subunit M654_RS09005 ENOG4108MDF Phage Portal Protein M654_RS09035 ENOG41060SN M654_RS09050 ENOG4105PQS phage protein M654_RS09055 ENOG4105FR7 XkdM protein, phage-like element PBSX M654_RS09060 ENOG4105MTC XkdN-like protein M654_RS09070 ENOG4108FKH Transglycosylase SLT domain M654_RS09070 ENOG4108FKH Transglycosylase SLT domain M654_RS09075 ENOG4108WZM domain protein M654_RS09080 ENOG4105X7F M654_RS09090 ENOG4105MFU Protein of unknown function (DUF2634) M654_RS09095 ENOG41066EA baseplate J family protein M654_RS09100 ENOG410906S phage-like element pbsx protein xkdt M654_RS09110 ENOG41068G1 M654_RS09115 ENOG41068G1 M654_RS09120 ENOG4107VXM glycerophosphoryl diester phosphodiesterase M654_RS09125 ENOG41068G1 M654_RS09145 ENOG4107XBN GntR Family Transcriptional Regulator M654_RS09150 ENOG4105CPQ Dehydrogenase M654_RS09155 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) M654_RS09160 ENOG4105DMW Dehydrogenase reductase M654_RS09165 ENOG4105CPQ Dehydrogenase M654_RS09170 ENOG4108I5G Major Facilitator superfamily M654_RS09190 ENOG4105CJ3 phosphate transporter M654_RS09195 ENOG4107GRR phosphate transport regulator M654_RS09200 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) M654_RS09210 ENOG4105C2F Histidine kinase M654_RS09215 ENOG4105EQD regulatoR M654_RS09220 ENOG410769Z extracellular solute-binding protein family 1 M654_RS09225 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component M654_RS09230 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M654_RS09235 ENOG4105F5H Glycosyl Hydrolase Family 88 M654_RS09240 ENOG41075H3 AraC family transcriptional regulator M654_RS09245 ENOG4107TDE lipolytic protein G-D-S-L family M654_RS09260 ENOG4105CX8 fg-gap repeat protein M654_RS09265 ENOG4107TDE lipolytic protein G-D-S-L family M654_RS09270 ENOG4105CX8 fg-gap repeat protein M654_RS09280 ENOG4107TDE lipolytic protein G-D-S-L family M654_RS09290 ENOG4105EKC M654_RS09295 ENOG4105E0S extracellular solute-binding protein family 1 M654_RS09305 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component M654_RS09310 ENOG4107R7I amino acid M654_RS09320 ENOG4105C0H protease M654_RS09370 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase M654_RS09390 ENOG4108ME1 Peptidase M55 D-aminopeptidase M654_RS09395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_RS09400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_RS09405 ENOG4105C3U ABC transporter M654_RS09415 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A M654_RS09420 ENOG4105DTQ mandelate racemase muconate lactonizing M654_RS09425 ENOG4107SN7 NLP P60 protein M654_RS09430 ENOG4108JQ7 (ABC) transporter M654_RS09440 ENOG4107TUM Amidinotransferase M654_RS09445 ENOG4108S4H thioesterase Superfamily protein M654_RS09450 ENOG4108J20 pectate lyase M654_RS09470 ENOG410839T multidrug resistance protein M654_RS09475 ENOG41080TC multidrug resistance protein M654_RS09480 ENOG4105CIY formyltetrahydrofolate deformylase M654_RS09485 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) M654_RS09490 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) M654_RS09500 ENOG4105K56 Transcriptional regulator M654_RS09505 ENOG4108ZHJ Organic hydroperoxide resistance protein M654_RS09515 ENOG4107Y2X deaminase M654_RS09520 ENOG4105CVJ phosphoglycerate mutase M654_RS09535 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) M654_RS09540 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin M654_RS09550 ENOG4105CJW magnesium transporter M654_RS09560 ENOG4105V75 Transcriptional regulator M654_RS09575 ENOG4105DQE DNA ligase M654_RS09580 ENOG4105FDF Could be involved in DNA repair (By similarity) M654_RS09585 ENOG4105BZU Histidine kinase M654_RS09590 ENOG4107T5V SNARE associated Golgi M654_RS09595 ENOG4107TS3 membrane protein, TerC M654_RS09600 ENOG4108WZW RNA polymerase sigma M654_RS09610 ENOG410681C small acid-soluble spore protein M654_RS09620 ENOG4105D0M Protease HtpX homolog M654_RS09630 ENOG4107RVG penicillin-binding protein M654_RS09640 ENOG4108TGC Acyltransferase M654_RS09645 ENOG4105BZU Histidine kinase M654_RS09650 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) M654_RS09655 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) M654_RS09665 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase M654_RS09675 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate M654_RS09690 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) M654_RS09695 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) M654_RS09715 ENOG41090MY MarR family Transcriptional regulator M654_RS09720 ENOG4105ER2 Ompa motb domain protein M654_RS09725 ENOG4105E14 MotA TolQ exbB proton channel M654_RS09735 ENOG4108K88 Membrane M654_RS09740 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) M654_RS09745 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase M654_RS09750 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) M654_RS09755 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) M654_RS09800 ENOG4105NX3 Membrane M654_RS09805 ENOG4105VMP Transcriptional regulator M654_RS09845 ENOG4105F0V Cell wall hydrolase M654_RS09860 ENOG4105C59 p-type ATPase M654_RS09865 ENOG4105DC7 peptidase M24 M654_RS09880 ENOG4105CID antiterminator M654_RS09890 ENOG4105KRI phosphocarrier protein (HPr M654_RS09895 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) M654_RS09905 ENOG4105F6S Spore photoproduct lyase M654_RS09915 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer M654_RS09920 ENOG4105CHR reductase M654_RS09925 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase M654_RS09930 ENOG4105K4I Scp-like extracellular M654_RS09940 ENOG4105BZU Histidine kinase M654_RS09945 ENOG4105CHM Aminotransferase M654_RS09955 ENOG41085PJ rdd domain containing protein M654_RS09965 ENOG4107R88 Chemotaxis protein (CheV) M654_RS09970 ENOG4105UIN M654_RS09980 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein M654_RS09990 ENOG4105K6S Short-chain dehydrogenase reductase Sdr M654_RS09995 ENOG4105EPM Diguanylate phosphodiesterase M654_RS10000 ENOG4107IN1 Protein of unknown function (DUF1797) M654_RS10005 ENOG4108XRC Protein of unknown function (DUF458) M654_RS10035 ENOG4105NQC Flavodoxin M654_RS10040 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) M654_RS10055 ENOG4105D3R alkyl hydroperoxide reductase M654_RS10060 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M654_RS10075 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) M654_RS10080 ENOG4105D06 uba thif-type nad fad binding protein M654_RS10085 ENOG4105CVM Molybdenum cofactor synthesis domain protein M654_RS10090 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein M654_RS10095 ENOG4108ZAF Molybdopterin M654_RS10100 ENOG41067WU Molybdopterin converting factor (Subunit 1) M654_RS10110 ENOG4105BZ1 (ABC) transporter M654_RS10115 ENOG4105BZ1 (ABC) transporter M654_RS10125 ENOG4107X8C Efflux transporter RND family MFP subunit M654_RS10130 ENOG4105C19 ABC transporter M654_RS10135 ENOG4107RBB ABC transporter, permease M654_RS10145 ENOG4105E98 transcriptional regulator DeoR family M654_RS10150 ENOG4105DE4 1-phosphofructokinase M654_RS10155 ENOG4105DM4 PTS System M654_RS10160 ENOG4105C3F Signal peptidase i M654_RS10175 ENOG4105C5H ABC transporter M654_RS10205 ENOG4105BZU Histidine kinase M654_RS10210 ENOG4107ZYR domain protein M654_RS10220 ENOG4105CN5 Metallo-Beta-Lactamase M654_RS10230 ENOG4108X4Q Hydrolase M654_RS10235 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) M654_RS10255 ENOG4105CPP Dehydrogenase, E1 component M654_RS10260 ENOG4105C7S Dehydrogenase M654_RS10265 ENOG4107QN2 dihydrolipoyl dehydrogenase M654_RS10280 ENOG4105CXN decarboxylase M654_RS10285 ENOG4105WBI UPF0223 protein M654_RS10300 ENOG4105ECY inositol monophosphatase M654_RS10325 ENOG4105EAA nucleoside M654_RS10335 ENOG4105CI3 gtp-binding protein typa M654_RS10340 ENOG4105QA2 M654_RS10345 ENOG4108INS Transcriptional regulator M654_RS10350 ENOG4107SCK Monooxygenase M654_RS10365 ENOG4108IAB Phoh family M654_RS10375 ENOG4105CSV Glutaminase M654_RS10380 ENOG4105ZPI UPF0358 protein M654_RS10385 ENOG4105CNI cell division protein FtsW M654_RS10390 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) M654_RS10400 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) M654_RS10410 ENOG4105BZ9 Cytochrome C oxidase, subunit I M654_RS10415 ENOG4105CCU oxidase (Subunit III) M654_RS10420 ENOG41064X9 cytochrome C oxidase subunit IV M654_RS10435 ENOG41080XQ Signal transduction protein with cbs domains M654_RS10440 ENOG4106UY4 Inherit from COG: Scp-like extracellular M654_RS10465 ENOG4106H78 methyltransferase M654_RS10470 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) M654_RS10475 ENOG4105H20 Sporulation integral membrane protein YlbJ M654_RS10480 ENOG41063PX domain protein M654_RS10485 ENOG4105CDE UPF0348 protein M654_RS10490 ENOG4105KNH Nucleic acid-binding protein M654_RS10495 ENOG41067VY 50S ribosomal protein L32 M654_RS10515 ENOG41074B2 UPF0747 protein M654_RS10520 ENOG4108V6E Cell division protein mraZ M654_RS10525 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) M654_RS10535 ENOG4105CJN penicillin-binding protein M654_RS10540 ENOG4105CJN penicillin-binding protein M654_RS10545 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) M654_RS10550 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) M654_RS10555 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) M654_RS10560 ENOG4105CNI cell division protein FtsW M654_RS10565 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) M654_RS10570 ENOG4105D4A Cell wall formation (By similarity) M654_RS10575 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) M654_RS10580 ENOG4108R2U division initiation protein M654_RS10590 ENOG4105K67 small basic protein M654_RS10595 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) M654_RS10600 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) M654_RS10615 ENOG4105FFI sigma-e processing peptidase spoiiga M654_RS10620 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_RS10630 ENOG4105DKW ABC transporter M654_RS10635 ENOG4105DHI Methyltransferase M654_RS10640 ENOG4105WR5 sporulation protein, YlmC YmxH family M654_RS10645 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase M654_RS10650 ENOG4105DFA alanine racemase domain protein M654_RS10655 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) M654_RS10660 ENOG41067XK integral membrane protein M654_RS10665 ENOG4105DBK s4 domain protein M654_RS10685 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) M654_RS10690 ENOG4105C34 Pseudouridine synthase M654_RS10695 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) M654_RS10705 ENOG4105CXT aspartate transcarbamylase M654_RS10710 ENOG4105CD3 dihydroorotase M654_RS10715 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain M654_RS10720 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain M654_RS10725 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) M654_RS10730 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) M654_RS10735 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) M654_RS10750 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) M654_RS10770 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) M654_RS10775 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein M654_RS10780 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein M654_RS10795 ENOG4105DSJ YicC domain protein M654_RS10800 ENOG4105KC4 UPF0296 protein M654_RS10805 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) M654_RS10810 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) M654_RS10815 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase M654_RS10820 ENOG4105C25 Primosomal protein n' M654_RS10825 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) M654_RS10830 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) M654_RS10835 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B M654_RS10840 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs M654_RS10845 ENOG4108ZF3 Phosphatase M654_RS10850 ENOG4105D9P serine threonine protein kinase M654_RS10855 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) M654_RS10860 ENOG4105DJV ribulose-phosphate 3-epimerase M654_RS10865 ENOG4105FJ0 thiamine M654_RS10875 ENOG4105VB9 50S ribosomal protein l28 M654_RS10880 ENOG4108ZAA Alkaline-shock protein M654_RS10885 ENOG4105DP4 dak2 domain fusion protein ylov M654_RS10895 ENOG4105EJQ L-serine dehydratase M654_RS10900 ENOG4105CB5 ATP-dependent DNA helicase recG M654_RS10905 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) M654_RS10910 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) M654_RS10915 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase M654_RS10920 ENOG4105CHR reductase M654_RS10925 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) M654_RS10930 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) M654_RS10935 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) M654_RS10940 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) M654_RS10945 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) M654_RS10955 ENOG4105K5M 30s ribosomal protein S16 M654_RS10960 ENOG4108BW8 UPF0109 protein M654_RS10970 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) M654_RS10975 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) M654_RS10980 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) M654_RS10985 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) M654_RS10990 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) M654_RS11000 ENOG4105VM1 flagellar M654_RS11005 ENOG4105CMV Succinyl-CoA synthetase subunit beta M654_RS11010 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha M654_RS11015 ENOG4105C79 DNA protecting protein DprA M654_RS11020 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) M654_RS11025 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) M654_RS11030 ENOG4108HE4 integrase family M654_RS11035 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) M654_RS11040 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) M654_RS11045 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) M654_RS11050 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) M654_RS11055 ENOG4108ZC9 flagellar basal-body rod protein flgc M654_RS11060 ENOG4105VQ0 flagellar hook-basal body complex protein fliE M654_RS11065 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) M654_RS11070 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) M654_RS11085 ENOG4106YF4 Flagellar biosynthesis chaperone M654_RS11095 ENOG410696Y Flagellar hook-length control protein M654_RS11100 ENOG410822I Flagellar hook capping protein M654_RS11105 ENOG4108JQA flagellar M654_RS11110 ENOG41068WV flagellar FlbD family protein M654_RS11120 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) M654_RS11125 ENOG4105DD5 Flagellar motor switch protein M654_RS11130 ENOG4107YTP response regulator receiver protein M654_RS11140 ENOG4105CN7 Flagellar biosynthetic protein FliP M654_RS11145 ENOG4105VS8 Flagellar biosynthetic protein fliq M654_RS11150 ENOG4105D19 Role in flagellar biosynthesis (By similarity) M654_RS11155 ENOG4105D00 flagellar biosynthetic protein flhB M654_RS11160 ENOG4105D7B Flagellar biosynthesis protein flha M654_RS11165 ENOG4105FZW flagellar biosynthesis regulator FlhF M654_RS11175 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) M654_RS11180 ENOG4105CBS Chea signal transduction histidine kinase M654_RS11185 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis M654_RS11195 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) M654_RS11200 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_RS11210 ENOG4105CE9 30S ribosomal protein S2 M654_RS11215 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) M654_RS11225 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) M654_RS11230 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) M654_RS11235 ENOG4105KNE Phosphatidate cytidylyltransferase M654_RS11245 ENOG4105DZP Membrane-associated zinc metalloprotease M654_RS11255 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) M654_RS11265 ENOG4105CYP glycoside hydrolase, family M654_RS11275 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) M654_RS11280 ENOG4105CHV Transcription elongation factor NusA M654_RS11285 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination M654_RS11290 ENOG4105VHM ribosomal protein M654_RS11295 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) M654_RS11300 ENOG4105W7A Protein of unknown function (DUF503) M654_RS11305 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) M654_RS11310 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) M654_RS11315 ENOG4105DTN riboflavin biosynthesis protein ribF M654_RS11320 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) M654_RS11325 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) M654_RS11335 ENOG4105C1V Peptidase, M16 M654_RS11345 ENOG4105E35 Dipicolinate synthase subunit A M654_RS11350 ENOG4108S0H Dipicolinic acid synthetase, b subunit M654_RS11355 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) M654_RS11365 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) M654_RS11375 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit M654_RS11385 ENOG4105CNU cell division protein FtsK M654_RS11390 ENOG4105FDP GntR family transcriptional regulator M654_RS11410 ENOG4108RKS Short-chain dehydrogenase reductase Sdr M654_RS11415 ENOG4105XZV Protein of unknown function (DUF3243) M654_RS11430 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase M654_RS11435 ENOG4105CEV competence damage-inducible protein M654_RS11440 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) M654_RS11450 ENOG4105D48 metallophosphoesterase M654_RS11455 ENOG4105MCT stage V sporulation protein S M654_RS11460 ENOG4108IGT Dipeptidase M654_RS11465 ENOG4105CPQ Dehydrogenase M654_RS11470 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) M654_RS11475 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) M654_RS11490 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) M654_RS11495 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) M654_RS11510 ENOG4108NHD germination protein M654_RS11570 ENOG41067QW Transcriptional regulator M654_RS11590 ENOG4105K7K Transcriptional regulator M654_RS11615 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein M654_RS11620 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_RS11625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_RS11630 ENOG4108RZA ABC transporter M654_RS11635 ENOG4108S9F abc transporter, atp-binding protein M654_RS11650 ENOG4105I1F Resistance protein M654_RS11660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M654_RS11685 ENOG4108IBT Inherit from COG: transposase M654_RS11690 ENOG4105EAH synthase M654_RS11705 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) M654_RS11715 ENOG4105XPP Protein of unknown function (DUF1275) M654_RS11725 ENOG4105U6C Alpha beta hydrolase fold protein M654_RS11740 ENOG41080BT SNARE associated Golgi M654_RS11745 ENOG4105FQP Beta-lactamase M654_RS11750 ENOG41087PP glycosyltransferase MGT family M654_RS11755 ENOG4107QTZ amino acid M654_RS11770 ENOG4105VRS hydrolase family 18 M654_RS11785 ENOG4108X3M OsmC Ohr family protein M654_RS11790 ENOG4107E54 Small Multidrug Resistance protein M654_RS11815 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) M654_RS11820 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) M654_RS11830 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) M654_RS11835 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M654_RS11840 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M654_RS11845 ENOG4105U6W MutT NUDIX family protein M654_RS11850 ENOG4105DRR Transcriptional regulator, GntR family M654_RS11870 ENOG4105K59 histidine triad (HIT) protein M654_RS11880 ENOG4106BHF M654_RS11905 ENOG4106BHF M654_RS11910 ENOG4106ANW SMI1_KNR4 M654_RS11950 ENOG4108YZ9 Urea amidohydrolase subunit gamma M654_RS11955 ENOG4105KI2 Urea amidohydrolase subunit beta M654_RS11965 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) M654_RS11970 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) M654_RS11975 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) M654_RS11980 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) M654_RS11990 ENOG4105U3E Transcriptional regulator M654_RS12000 ENOG4106F1P AAA ATPase, central domain protein M654_RS12005 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) M654_RS12010 ENOG4105CXI aluminum resistance protein M654_RS12015 ENOG4105KV4 Transcriptional regulator M654_RS12020 ENOG4105C5F glutamine synthetase M654_RS12170 ENOG4105CAR Terminase, large subunit M654_RS12245 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase M654_RS12285 ENOG4107EV6 Inherit from COG: YD repeat protein M654_RS12340 ENOG4105ETZ PTS System M654_RS12345 ENOG4105F3R pts system mannose fructose sorbose family iid M654_RS12355 ENOG410635A Membrane M654_RS12385 ENOG4105CAT Cytidine monophosphate kinase M654_RS12405 ENOG4105GIG M654_RS12425 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) M654_RS12465 ENOG4108MK9 spermidine N(1)-acetyltransferase M654_RS12490 ENOG4105WQG acetyltransferase M654_RS12500 ENOG41062JF Transcriptional regulator M654_RS12520 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) M654_RS12535 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) M654_RS12545 ENOG4108SVB resolvase M654_RS12550 ENOG4105VPS UPF0291 protein M654_RS12555 ENOG4105CV1 Transketolase (EC 2.2.1.1) M654_RS12565 ENOG4105VXM UPF0154 protein M654_RS12575 ENOG4107QIV Cytochrome c biogenesis protein M654_RS12600 ENOG41076DU acid-soluble spore protein P M654_RS12610 ENOG4108I0Z Aconitate hydratase M654_RS12630 ENOG41067CD Small, acid-soluble spore protein Tlp M654_RS12640 ENOG4105MI2 M654_RS12645 ENOG4105W8X HesB YadR YfhF-family protein M654_RS12650 ENOG4105W8X HesB YadR YfhF-family protein M654_RS12655 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) M654_RS12660 ENOG4105K4P CoA-binding domain protein M654_RS12665 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M654_RS12675 ENOG4105CHR reductase M654_RS12700 ENOG4105R3A Nitrate reductase M654_RS12705 ENOG4108IUE nitrate reductase beta subunit M654_RS12740 ENOG4107V6Q Cyclic nucleotide-binding domain M654_RS12760 ENOG4105DSQ Nitric oxide reductase M654_RS12765 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) M654_RS12770 ENOG4106U2H Protein of unknown function (DUF1360) M654_RS12775 ENOG4107QWR cellulase (EC 3.2.1.4) M654_RS12785 ENOG4108428 Inherit from COG: -acetyltransferase M654_RS12795 ENOG4105F27 Major Facilitator M654_RS12805 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) M654_RS12820 ENOG4108M26 parallel beta-helix repeat protein M654_RS12850 ENOG41060WC Enoyl-CoA hydratase M654_RS12855 ENOG4105C26 Dehydrogenase M654_RS12860 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase M654_RS12865 ENOG4105C1G acyl-Coa dehydrogenase M654_RS12870 ENOG4105DG6 mannose-6-phosphate isomerase M654_RS12875 ENOG4105DM4 PTS System M654_RS12895 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family M654_RS12905 ENOG4108JGH Tetr family transcriptional regulator M654_RS12930 ENOG4105DSG hydrolase family 43 M654_RS12940 ENOG4105K63 Thioredoxin M654_RS12950 ENOG4105BZ1 (ABC) transporter M654_RS12955 ENOG4105BZ1 (ABC) transporter M654_RS12965 ENOG4105C28 cystathionine M654_RS12980 ENOG4106KE4 Dehydrogenase M654_RS12990 ENOG4108UXE Protein tyrosine phosphatase M654_RS12995 ENOG4107R5R arsenical pump membrane protein M654_RS13000 ENOG41082YX Transcriptional regulator, arsr family M654_RS13005 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) M654_RS13015 ENOG4105CSC Glucose uptake protein M654_RS13020 ENOG4105F32 YngK protein M654_RS13030 ENOG4105F1A Pyruvate formate-lyase M654_RS13040 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) M654_RS13045 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family M654_RS13050 ENOG4105D3P Mannan endo-1,4-beta-mannosidase M654_RS13060 ENOG4105ETE Transcriptional regulator (LacI family M654_RS13065 ENOG4105CS2 ec 3.2.1.21 M654_RS13075 ENOG4107FKK extracellular solute-binding protein family 1 M654_RS13080 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M654_RS13085 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component M654_RS13095 ENOG41066F8 ROK family M654_RS13145 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) M654_RS13150 ENOG4107QX3 carboxylase M654_RS13155 ENOG4105E39 Enoyl-CoA hydratase M654_RS13160 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase M654_RS13165 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit M654_RS13170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase M654_RS13175 ENOG4105CEY Amp-dependent synthetase and ligase M654_RS13180 ENOG4105C1G acyl-Coa dehydrogenase M654_RS13185 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) M654_RS13190 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) M654_RS13200 ENOG4105H67 Protein of unknown function (DUF421) M654_RS13205 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) M654_RS13210 ENOG4107RIQ Sulfate adenylate transferase M654_RS13220 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) M654_RS13225 ENOG41061P3 phosphosulfolactate synthase M654_RS13235 ENOG4105DIA mandelate racemase muconate lactonizing M654_RS13240 ENOG4107RCC Major Facilitator Superfamily M654_RS13260 ENOG4105BZ8 glutamate synthase M654_RS13265 ENOG4105CBC glutamate synthase M654_RS13270 ENOG4105C5Q Transcriptional regulator M654_RS13300 ENOG4105BZ1 (ABC) transporter M654_RS13305 ENOG4105DGI Alkaline phosphatase M654_RS13320 ENOG4105C0R drug resistance transporter emrb qaca subfamily M654_RS13325 ENOG4108J2R molybdopterin oxidoreductase M654_RS13340 ENOG4108Q8B Spore germination protein M654_RS13345 ENOG4108NHD germination protein M654_RS13350 ENOG4108Q8B Spore germination protein M654_RS13355 ENOG4108Q8B Spore germination protein M654_RS13370 ENOG4108NHD germination protein M654_RS13380 ENOG4105E1K spore germination protein M654_RS13395 ENOG4105C8Q Methyl-accepting chemotaxis M654_RS13400 ENOG4108Z7R Chaperone CsaA M654_RS13405 ENOG4105KNA -acetyltransferase M654_RS13410 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin M654_RS13420 ENOG4108RZE Tetr family transcriptional regulator M654_RS13430 ENOG4105T9C HD domain M654_RS13440 ENOG4105FVX M654_RS13460 ENOG4108W8B Beta-lactamase domain protein M654_RS13470 ENOG4105D29 Helix-turn-helix type 11 domain protein M654_RS13480 ENOG4105KTU Transcriptional regulator, arsr family M654_RS13495 ENOG4105CUB amino acid M654_RS13505 ENOG4105C5E polysaccharide biosynthesis protein M654_RS13520 ENOG4107T8Q Glycosyl transferase (Group 1 M654_RS13525 ENOG4108SJC Membrane M654_RS13545 ENOG4107RUZ Sss sodium solute transporter superfamily M654_RS13550 ENOG41069ER domain protein M654_RS13555 ENOG4105C9U ATP-dependent DNA helicase RecQ M654_RS13630 ENOG4108ZMX Domain of unknown function (DU1801) M654_RS13635 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase M654_RS13640 ENOG4105NPE arsR family transcriptional regulator M654_RS13680 ENOG4108NHD germination protein M654_RS13705 ENOG4105DXI Major Facilitator superfamily M654_RS13710 ENOG4107S9D Alpha beta hydrolase M654_RS13725 ENOG410829K Lysine exporter protein (Lyse ygga) M654_RS13730 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) M654_RS13735 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) M654_RS13780 ENOG4105SF0 DinB family M654_RS13785 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) M654_RS13790 ENOG4105SCY DNAK suppressor M654_RS13805 ENOG4105C26 Dehydrogenase M654_RS13815 ENOG4105CGD Nad-dependent epimerase dehydratase M654_RS13825 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) M654_RS13835 ENOG4105CPC Aldo Keto reductase M654_RS13840 ENOG4105EWU Squalene--hopene cyclase M654_RS13845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) M654_RS13860 ENOG4105C8J )-transporter M654_RS13865 ENOG4105C09 Bile acid M654_RS13870 ENOG4105C7S Dehydrogenase M654_RS13875 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 M654_RS13880 ENOG4107T89 von Willebrand factor, type A M654_RS13885 ENOG4105GMT ATPase associated with various cellular activities aaa_5 M654_RS13895 ENOG4105K4H Nlp p60 protein M654_RS13920 ENOG4105FR1 rard protein M654_RS13930 ENOG4108YQE rare lipoprotein a M654_RS13955 ENOG4105FBA Phospholipase Carboxylesterase M654_RS13970 ENOG4105E1V na solute symporter M654_RS13990 ENOG4108VXD carboxy-peptidase M654_RS13995 ENOG4105D3A purine nucleoside phosphorylase DeoD-type M654_RS14000 ENOG4108PJD permease M654_RS14015 ENOG4106Z5R M654_RS14020 ENOG410841Q phosphoesterase PA-phosphatase related protein M654_RS14035 ENOG4105VSD UPF0346 protein M654_RS14045 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein M654_RS14050 ENOG4108TSC N-acetyltransferase M654_RS14055 ENOG4107S4Y M20 DapE family protein YgeY M654_RS14070 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) M654_RS14090 ENOG4105E0X reductase M654_RS14125 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) M654_RS14130 ENOG41090WU lipolytic protein G-D-S-L family M654_RS14135 ENOG4108KF3 Electron transport protein SCO1 SenC M654_RS14150 ENOG4105C7B Threonine dehydratase M654_RS14160 ENOG4108UT2 hemolysin iii M654_RS14170 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) M654_RS14185 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) M654_RS14190 ENOG4107YX5 Pfam:DUF548 M654_RS14200 ENOG4105C01 Dihydroxy-acid dehydratase M654_RS14215 ENOG4108V06 Glutathione peroxidase M654_RS14220 ENOG4105CKU formyltetrahydrofolate synthetase M654_RS14225 ENOG4105CVG Homoserine O-transsuccinylase M654_RS14230 ENOG4108QBV Monogalactosyldiacylglycerol synthase M654_RS14270 ENOG41081VK Ribonuclease M654_RS14290 ENOG410890F Dynamin family M654_RS14305 ENOG41065KQ synthase M654_RS14315 ENOG4105C2W permease M654_RS14320 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) M654_RS14325 ENOG4105CTD carboxy-peptidase M654_RS14330 ENOG4105DVT helicase M654_RS14340 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) M654_RS14350 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) M654_RS14355 ENOG4108UKS UPF0398 protein M654_RS14365 ENOG4107X2U Inherit from COG: Exonuclease-like protein M654_RS14370 ENOG4108I5C dEAD DEAH box helicase M654_RS14420 ENOG4105BZ4 penicillin-binding protein M654_RS14430 ENOG4105CSM endonuclease III M654_RS14445 ENOG4105CHM Aminotransferase M654_RS14455 ENOG4105YAC M654_RS14460 ENOG4105DVT helicase M654_RS14465 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) M654_RS14470 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) M654_RS14475 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) M654_RS14485 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate M654_RS14490 ENOG4105CPK Glycosyl transferase (Group 1 M654_RS14495 ENOG4105FJR Lmbe family M654_RS14500 ENOG4108Z5K methylglyoxal synthase M654_RS14505 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) M654_RS14510 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase M654_RS14515 ENOG4108JYZ YitT family M654_RS14535 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) M654_RS14550 ENOG4108SXZ UPF0302 protein M654_RS14555 ENOG41068YB TPR repeat-containing protein M654_RS14570 ENOG4105CIH Imidazole acetol-phosphate transaminase M654_RS14575 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) M654_RS14580 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) M654_RS14590 ENOG4105DK0 Indole-3-glycerol phosphate synthase M654_RS14595 ENOG4108I0Q anthranilate phosphoribosyltransferase M654_RS14600 ENOG4105CRQ synthase (Component I) M654_RS14605 ENOG4105KHN chorismate mutase M654_RS14610 ENOG4105D49 3-dehydroquinate synthase M654_RS14615 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase M654_RS14620 ENOG4105BZU Histidine kinase M654_RS14625 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) M654_RS14630 ENOG4105EAH synthase M654_RS14635 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) M654_RS14640 ENOG4105XXQ heptaprenyl diphosphate synthase component I M654_RS14650 ENOG4105EUJ GTP cyclohydrolase i M654_RS14655 ENOG4105K70 DNA-binding protein M654_RS14660 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) M654_RS14675 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase M654_RS14680 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) M654_RS14685 ENOG41065D1 M654_RS14690 ENOG4105S2F M654_RS14705 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) M654_RS14710 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) M654_RS14715 ENOG4105CAT Cytidine monophosphate kinase M654_RS14725 ENOG4105MSI germination protein ypeb M654_RS14740 ENOG4105HDK L-asparaginase M654_RS14745 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase M654_RS14760 ENOG4107RGJ metallophosphoesterase M654_RS14775 ENOG4105I7S Abortive infection protein M654_RS14780 ENOG4105C9U ATP-dependent DNA helicase RecQ M654_RS14785 ENOG4105T7X M654_RS14795 ENOG4108SAX Membrane M654_RS14800 ENOG4108JQ1 Dehydrogenase M654_RS14805 ENOG4105DR5 peptidase M654_RS14835 ENOG4105US7 Histidine kinase M654_RS14840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_RS14845 ENOG4105BZU Histidine kinase M654_RS14850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_RS14855 ENOG4105CRE cytochrome C M654_RS14860 ENOG4107TWT Cytochrome c biogenesis protein M654_RS14865 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M654_RS14870 ENOG4105FE9 pseudouridine synthase M654_RS14880 ENOG4108JIC nucleoside recognition domain protein M654_RS14885 ENOG4105DZ1 carboxypeptidase M654_RS14895 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) M654_RS14900 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) M654_RS14920 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) M654_RS14925 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) M654_RS14930 ENOG4108R6K riboflavin synthase, subunit alpha M654_RS14935 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) M654_RS14950 ENOG4107ZE5 PPIases accelerate the folding of proteins M654_RS14960 ENOG4105PTM secreted protein M654_RS14965 ENOG4105K7W phage-related replication protein M654_RS14970 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) M654_RS14985 ENOG4105G6R Stage v sporulation protein ae M654_RS14995 ENOG4105CZ3 stage V sporulation protein ad M654_RS15000 ENOG41090VF Stage v sporulation protein ac M654_RS15015 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_RS15020 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) M654_RS15025 ENOG41082AN stage II sporulation protein M654_RS15030 ENOG4105DZ1 carboxypeptidase M654_RS15040 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) M654_RS15045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) M654_RS15055 ENOG4105I3K Ferric uptake regulator, Fur family M654_RS15060 ENOG4105MZ9 stage II sporulation protein m M654_RS15065 ENOG4105CK1 PTS System M654_RS15070 ENOG4105VZJ PTS System M654_RS15075 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease M654_RS15100 ENOG4107YB6 acetyltransferase, (GNAT) family M654_RS15110 ENOG4108YZ4 nudix hydrolase M654_RS15120 ENOG4105PF9 Transcriptional regulator M654_RS15130 ENOG4105CPC Aldo Keto reductase M654_RS15150 ENOG4106HZJ M654_RS15160 ENOG4105RHY Pfam:UPF0157 M654_RS15165 ENOG4105KAC Antibiotic biosynthesis monooxygenase M654_RS15170 ENOG4108XET gCN5-related N-acetyltransferase M654_RS15175 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold M654_RS15185 ENOG4107RRN ABC transporter substrate-binding protein M654_RS15190 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_RS15195 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_RS15200 ENOG4108RZA ABC transporter M654_RS15210 ENOG4107R73 Mate efflux family protein M654_RS15225 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) M654_RS15240 ENOG4105E5W Transporter M654_RS15245 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase M654_RS15260 ENOG4105CDA abc transporter atp-binding protein M654_RS15285 ENOG4105BZU Histidine kinase M654_RS15290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_RS15300 ENOG4105K7W phage-related replication protein M654_RS15305 ENOG4108IXY short-chain dehydrogenase reductase M654_RS15310 ENOG41069FQ Metallo-beta-lactamase superfamily M654_RS15315 ENOG4105II7 pyrroline-5-carboxylate reductase M654_RS15325 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M654_RS15335 ENOG4105WDJ 50S ribosomal protein L33 M654_RS15340 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) M654_RS15345 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase M654_RS15360 ENOG4105H1G trap transporter solute receptor taxi family M654_RS15365 ENOG4105CIF Ornithine Cyclodeaminase M654_RS15380 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) M654_RS15400 ENOG4108TZY GntR Family Transcriptional Regulator M654_RS15405 ENOG4105CS2 ec 3.2.1.21 M654_RS15410 ENOG4105CK1 PTS System M654_RS15415 ENOG4105VCP PTS System M654_RS15420 ENOG4105VZJ PTS System M654_RS15425 ENOG4105G6Z alkaline phosphatase M654_RS15430 ENOG4105H9W Short-chain dehydrogenase reductase Sdr M654_RS15435 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) M654_RS15440 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) M654_RS15450 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) M654_RS15455 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) M654_RS15460 ENOG4108HNZ carboxyl transferase M654_RS15470 ENOG4108QEG Membrane M654_RS15475 ENOG4105CDA abc transporter atp-binding protein M654_RS15480 ENOG4105E5Q amino acid AbC transporter M654_RS15485 ENOG4108HW3 (ABC) transporter M654_RS15490 ENOG4108Y6J UPF0403 protein M654_RS15495 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) M654_RS15500 ENOG4105C7S Dehydrogenase M654_RS15505 ENOG4105CPP Dehydrogenase, E1 component M654_RS15520 ENOG4105CKM Branched-chain carboxylic acid kinase M654_RS15525 ENOG4107RDP Dehydrogenase M654_RS15535 ENOG4108JUB Transcriptional regulator M654_RS15540 ENOG4106CCJ Protein of unknown function (DUF2627) M654_RS15545 ENOG4108QXE glycerophosphoryl diester phosphodiesterase M654_RS15550 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M654_RS15565 ENOG4107QQR Sporulation M654_RS15570 ENOG4105S1Z Stage IV sporulation protein B M654_RS15575 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) M654_RS15580 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) M654_RS15585 ENOG4105DX0 Hemolysin A M654_RS15590 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) M654_RS15595 ENOG4105CTB Polyprenyl synthetase M654_RS15600 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) M654_RS15605 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) M654_RS15610 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) M654_RS15615 ENOG4105M7K Involved in the transcription termination process (By similarity) M654_RS15620 ENOG4108ZSR alkaline shock protein M654_RS15625 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase M654_RS15645 ENOG410644B Stage III sporulation protein af M654_RS15655 ENOG4105KQ4 Stage iii sporulation protein ad M654_RS15660 ENOG4108CQH stage III sporulation protein AC M654_RS15665 ENOG4105KR5 Stage iii sporulation protein M654_RS15670 ENOG4105CD2 stage iii sporulation protein aa M654_RS15680 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) M654_RS15685 ENOG4105DC7 peptidase M24 M654_RS15690 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) M654_RS15700 ENOG4105CBJ Metal-dependent enzyme M654_RS15715 ENOG4105KST dependent repressor M654_RS15720 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) M654_RS15725 ENOG4105WZW rhodanese family M654_RS15735 ENOG4107SQ8 Glycine betaine M654_RS15740 ENOG4108IJ7 Glycine betaine M654_RS15745 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor M654_RS15755 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) M654_RS15760 ENOG4105C0D helicase M654_RS15785 ENOG4105VFR signal peptidase M654_RS15825 ENOG4106855 Competence protein M654_RS15860 ENOG4105C5X domain protein M654_RS15905 ENOG4105E0M Sulfatase M654_RS15925 ENOG4107ZXI Rhomboid family M654_RS15930 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase M654_RS15935 ENOG4105WDJ 50S ribosomal protein L33 M654_RS15955 ENOG41068DG YceG-like family M654_RS15960 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) M654_RS15965 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) M654_RS15970 ENOG4105E2Z phosphate ABC transporter (Permease M654_RS15975 ENOG4105C8U phosphate abc transporter M654_RS15980 ENOG4105CVA phosphate M654_RS15985 ENOG4107RF6 penicillin-binding protein M654_RS15995 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) M654_RS16000 ENOG4105SXS Protein of unknown function (DUF456) M654_RS16015 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) M654_RS16020 ENOG41063Y9 M654_RS16025 ENOG4108U5J '-nucleotidase M654_RS16030 ENOG4105N80 Ferric uptake regulator, Fur family M654_RS16035 ENOG4105FAV ABC, transporter M654_RS16040 ENOG4105FDK ABC transporter M654_RS16045 ENOG4108JYZ YitT family M654_RS16050 ENOG41069ZM Protein of unknown function (DUF2624) M654_RS16055 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) M654_RS16070 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) M654_RS16080 ENOG4105EGD dinuclear metal center protein, YbgI family M654_RS16095 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_RS16100 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) M654_RS16110 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) M654_RS16120 ENOG4105C38 Glycyl-tRNA synthetase beta subunit M654_RS16125 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit M654_RS16130 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) M654_RS16140 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) M654_RS16145 ENOG4105KG3 cytidine deaminase M654_RS16150 ENOG4107YR5 Diacylglycerol kinase M654_RS16155 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) M654_RS16160 ENOG4105CTJ Metal Dependent Phosphohydrolase M654_RS16165 ENOG4105C9A Phoh family M654_RS16170 ENOG4105EI1 sporulation protein yqfd M654_RS16175 ENOG41068P3 sporulation protein YqfC M654_RS16185 ENOG4105DI5 UPF0365 protein M654_RS16190 ENOG4105F7J membrane-bound serine protease M654_RS16195 ENOG4105KTH gatB Yqey M654_RS16200 ENOG4105VCC 30S ribosomal protein S21 M654_RS16210 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) M654_RS16215 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) M654_RS16220 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) M654_RS16225 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) M654_RS16230 ENOG4105CFG Acts as a chaperone (By similarity) M654_RS16235 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ M654_RS16240 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) M654_RS16245 ENOG4105CSA Coproporphyrinogen iii oxidase M654_RS16250 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) M654_RS16260 ENOG4108ZRV stage ii sporulation protein p M654_RS16280 ENOG4105TQK DNA polymerase iii, delta' subunit M654_RS16290 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 M654_RS16295 ENOG4108UK2 deaminase M654_RS16300 ENOG4105KQC Competence protein M654_RS16310 ENOG4108D32 Methyltransferase M654_RS16320 ENOG4108WF2 Metal Dependent Phosphohydrolase M654_RS16325 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) M654_RS16330 ENOG410812S Rna-binding protein M654_RS16335 ENOG4105E2X shikimate dehydrogenase M654_RS16340 ENOG4105CQW ribosome biogenesis GTPase YqeH M654_RS16345 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase M654_RS16365 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) M654_RS16370 ENOG4108JB9 formate dehydrogenase M654_RS16385 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_RS16395 ENOG4105VRR gCN5-related N-acetyltransferase M654_RS16440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M654_RS16460 ENOG4105KME endoribonuclease L-psp M654_RS16465 ENOG4105HDK L-asparaginase M654_RS16470 ENOG4105C6T cysteine synthase M654_RS16475 ENOG4105KME endoribonuclease L-psp M654_RS16520 ENOG4105UNS Pfam:DUF419 M654_RS16545 ENOG4105G6Z alkaline phosphatase M654_RS16550 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein M654_RS16555 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_RS16560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_RS16570 ENOG4108JQ7 (ABC) transporter M654_RS16575 ENOG4105ECK Fatty Acid Desaturase M654_RS16580 ENOG4108ZGX Histidine kinase M654_RS16585 ENOG4108S01 response regulator M654_RS16590 ENOG4105CAY ferredoxin--nadp reductase M654_RS16600 ENOG4105CKI cobalamin synthesis protein M654_RS16605 ENOG4108NNI Beta-lactamase domain-containing protein M654_RS16610 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) M654_RS16615 ENOG4105D52 delta-aminolevulinic acid dehydratase M654_RS16620 ENOG4108UNV SUF system FeS assembly protein, NifU family M654_RS16625 ENOG4105DSE periplasmic solute binding protein M654_RS16630 ENOG4105DIK (ABC) transporter M654_RS16640 ENOG41090U3 tautomerase M654_RS16655 ENOG4105EWI Short-chain dehydrogenase reductase Sdr M654_RS16660 ENOG4107Y9E nuclease M654_RS16680 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein M654_RS16690 ENOG41087NI Sulfite exporter TauE/SafE M654_RS16705 ENOG4105WH1 Two component transcriptional regulator luxr family M654_RS16710 ENOG4105BZU Histidine kinase M654_RS16735 ENOG4105DSG hydrolase family 43 M654_RS16740 ENOG4105CT4 transporter M654_RS16745 ENOG4105EWI Short-chain dehydrogenase reductase Sdr M654_RS16750 ENOG4108HKT sucrose-6-phosphate hydrolase M654_RS16755 ENOG4105F3R pts system mannose fructose sorbose family iid M654_RS16760 ENOG4105ETZ PTS System M654_RS16765 ENOG4108IQ3 PTS system M654_RS16770 ENOG4105YHU PTS system M654_RS16775 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family M654_RS16780 ENOG4105G7B Protein of unknown function (DUF2992) M654_RS16805 ENOG4105WDR M654_RS16810 ENOG41068K0 YCII-related domain M654_RS16830 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) M654_RS16860 ENOG4105CV8 reductase M654_RS16865 ENOG4105F27 Major Facilitator M654_RS16870 ENOG4105KVH Transcriptional regulator M654_RS16875 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) M654_RS16880 ENOG4105EXQ uroporphyrinogen iii synthase hem4 M654_RS16920 ENOG4105D94 Major Facilitator Superfamily M654_RS16925 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) M654_RS16930 ENOG41082JN Transcriptional regulator M654_RS16960 ENOG4105C28 cystathionine M654_RS16970 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) M654_RS16975 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) M654_RS16990 ENOG4107XRG penicillin-binding protein M654_RS16995 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) M654_RS17005 ENOG4105CFP Peptidase U32 M654_RS17010 ENOG4105XYU peptidase (U32 family) M654_RS17020 ENOG4105HHA aminodeoxychorismate lyase M654_RS17025 ENOG4105VPH UPF0473 protein M654_RS17030 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) M654_RS17035 ENOG4105VBH UPF0297 protein M654_RS17040 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) M654_RS17045 ENOG4105C02 permease M654_RS17055 ENOG41060CR M654_RS17065 ENOG4105C7H Helicase, RecD TraA family M654_RS17075 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) M654_RS17080 ENOG4105C3J Cysteine desulfurase M654_RS17090 ENOG4105D1H recombination factor protein RarA M654_RS17095 ENOG4105CUZ uba thif-type nad fad binding protein M654_RS17105 ENOG4105C9M aspartyl-trna synthetase M654_RS17110 ENOG4105CUT histidyl-tRNA synthetase M654_RS17120 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M654_RS17125 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) M654_RS17130 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) M654_RS17135 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) M654_RS17140 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) M654_RS17145 ENOG41067VP Protein of unknown function (DUF1049) M654_RS17150 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) M654_RS17160 ENOG4105CKP Polysaccharide Biosynthesis Protein M654_RS17165 ENOG4108QG2 Membrane M654_RS17170 ENOG4105NAP M654_RS17175 ENOG4105VIE preprotein translocase, subunit YajC M654_RS17180 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) M654_RS17185 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) M654_RS17190 ENOG41061AI Protein of unknown function (DUF2905) M654_RS17195 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) M654_RS17200 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) M654_RS17215 ENOG41069DP small acid-soluble spore protein M654_RS17225 ENOG4105K7W phage-related replication protein M654_RS17240 ENOG4105CDY transcriptional regulatory protein M654_RS17250 ENOG4106678 morphogenetic protein associated with SpoVID M654_RS17255 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) M654_RS17260 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase M654_RS17265 ENOG4108IYU L-aspartate oxidase M654_RS17280 ENOG4105CQC Prephenate dehydratase M654_RS17285 ENOG41090I5 UPF0735 ACT domain-containing protein M654_RS17290 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control M654_RS17300 ENOG4105K46 50S ribosomal protein l27 M654_RS17305 ENOG4105X36 (ribosomal) protein M654_RS17310 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) M654_RS17330 ENOG41082BM Transcriptional regulator, arsr family M654_RS17335 ENOG4107QMS site-determining protein M654_RS17340 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) M654_RS17345 ENOG4105YHC Rod shape-determining protein MreD M654_RS17355 ENOG4105DFF Rod shape-determining protein mreb M654_RS17360 ENOG4105W5Q DNA repair protein (RadC M654_RS17365 ENOG4108Z03 MAF-like protein M654_RS17375 ENOG4106A3R peptidase M654_RS17380 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase M654_RS17385 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) M654_RS17395 ENOG4106AR7 Spore coat protein M654_RS17400 ENOG41068KH stage VI sporulation protein D M654_RS17405 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase M654_RS17410 ENOG4105D52 delta-aminolevulinic acid dehydratase M654_RS17420 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) M654_RS17430 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) M654_RS17440 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) M654_RS17445 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) M654_RS17450 ENOG4108IUQ atp-dependent protease M654_RS17455 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) M654_RS17460 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation M654_RS17470 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) M654_RS17475 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) M654_RS17480 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) M654_RS17485 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) M654_RS17490 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase M654_RS17495 ENOG4108ZP8 Acetolactate synthase small subunit M654_RS17500 ENOG4105C7K acetolactate synthase M654_RS17505 ENOG4105CM2 brancheD-chain amino acid aminotransferase M654_RS17515 ENOG4107R37 Glutamate dehydrogenase M654_RS17540 ENOG4105M59 Phosphodiesterase, mj0936 family M654_RS17545 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) M654_RS17550 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) M654_RS17555 ENOG4108XJQ germination protein M654_RS17560 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) M654_RS17565 ENOG41067TZ transcriptional regulator, MarR family M654_RS17570 ENOG4105PFC Transcriptional regulator M654_RS17575 ENOG4107FW0 short-chain dehydrogenase reductase M654_RS17585 ENOG4105E33 succinate dehydrogenase M654_RS17595 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit M654_RS17610 ENOG4105CFH Aspartokinase M654_RS17615 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) M654_RS17620 ENOG4105K63 Thioredoxin M654_RS17625 ENOG4105C10 Electron transfer flavoprotein M654_RS17630 ENOG4105BZJ Electron transfer flavoprotein M654_RS17635 ENOG41060WC Enoyl-CoA hydratase M654_RS17640 ENOG4107Z3H Transcriptional regulator, TetR family M654_RS17645 ENOG4105CEY Amp-dependent synthetase and ligase M654_RS17655 ENOG4105C98 muts2 protein M654_RS17660 ENOG4105DCG PHP domain protein M654_RS17670 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) M654_RS17675 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) M654_RS17690 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) M654_RS17695 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) M654_RS17700 ENOG4108RWN rrna methyltransferase M654_RS17705 ENOG41067MF small acid-soluble spore protein M654_RS17720 ENOG410905X membrane-flanked domain protein M654_RS17740 ENOG4105DRS transport system, permease M654_RS17755 ENOG4108MDK Dehydrogenase M654_RS17760 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase M654_RS17765 ENOG4105EF1 ribulokinase M654_RS17770 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) M654_RS17775 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase M654_RS17780 ENOG4105CN9 Peptidase m42 family protein M654_RS17790 ENOG410696E Membrane M654_RS17795 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) M654_RS17800 ENOG4105VJV 50s ribosomal protein L35 M654_RS17805 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) M654_RS17810 ENOG4105DGI Alkaline phosphatase M654_RS17815 ENOG4108HRK Histidine kinase M654_RS17825 ENOG4105C22 threonyL-tRNA synthetase M654_RS17830 ENOG4108TDW sporulation protein YtxC M654_RS17850 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) M654_RS17860 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) M654_RS17865 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase M654_RS17870 ENOG4108NR7 pectate lyase M654_RS17875 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) M654_RS17885 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) M654_RS17890 ENOG4105C2M dna polymerase I M654_RS17895 ENOG4105BZU Histidine kinase M654_RS17900 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_RS17905 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) M654_RS17910 ENOG4108HMX isocitrate dehydrogenase (NADP) M654_RS17915 ENOG4105BZN citrate synthase M654_RS17920 ENOG4108VMM UPF0756 membrane protein M654_RS17925 ENOG4108REF Sporulation integral membrane protein ytvi M654_RS17930 ENOG4105FS0 cytoplasmic membrane protein M654_RS17935 ENOG4105CA9 Pyruvate kinase M654_RS17940 ENOG4105CTQ phosphohexokinase M654_RS17945 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) M654_RS17955 ENOG4105C6K Malic enzyme M654_RS17960 ENOG4105C0B DNA polymerase III (alpha subunit) M654_RS17965 ENOG4105VV2 M654_RS17975 ENOG4106EVM M654_RS17980 ENOG4105SFS phosphoesterase RecJ domain protein M654_RS17995 ENOG4105U3E Transcriptional regulator M654_RS18005 ENOG4105E8R UPF0173 metal-dependent hydrolase M654_RS18015 ENOG4105CH7 arginosuccinase M654_RS18020 ENOG4105CDH Citrulline--aspartate ligase M654_RS18025 ENOG4105EPU Molybdenum cofactor synthesis domain protein M654_RS18030 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) M654_RS18040 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) M654_RS18045 ENOG4105KBJ sporulation protein ytfj M654_RS18055 ENOG4105VK3 rdd domain containing protein M654_RS18060 ENOG4105D07 Signal peptide peptidase, SppA M654_RS18070 ENOG4105CW7 secretion protein, HlyD family M654_RS18080 ENOG41061AU MarR family Transcriptional regulator M654_RS18085 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) M654_RS18095 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) M654_RS18120 ENOG4105U5Y Transcriptional regulator M654_RS18130 ENOG4105BZU Histidine kinase M654_RS18135 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) M654_RS18155 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) M654_RS18165 ENOG4105F1V Acetoin utilization protein M654_RS18170 ENOG4105W87 Cbs domain M654_RS18175 ENOG4105DGU Histone deacetylase M654_RS18180 ENOG4105ER2 Ompa motb domain protein M654_RS18185 ENOG4107R0U MotA TolQ exbB proton channel M654_RS18190 ENOG4105ETE Transcriptional regulator (LacI family M654_RS18195 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase M654_RS18220 ENOG4105DFU Cell wall formation (By similarity) M654_RS18230 ENOG4108VDD TRNA binding domain protein M654_RS18245 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ M654_RS18260 ENOG4105C6K Malic enzyme M654_RS18265 ENOG4105C8F Beta-lactamase domain protein M654_RS18270 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) M654_RS18280 ENOG4108V15 phosphotransferase enzyme family M654_RS18285 ENOG4108IUM Glycogen debranching enzyme M654_RS18300 ENOG4107F58 2'-5' rna ligase M654_RS18305 ENOG4105C6T cysteine synthase M654_RS18315 ENOG4107QSE Dipeptidase M654_RS18320 ENOG4105C7N Xanthine uracil vitamin C permease M654_RS18335 ENOG4105YW5 deoR family transcriptional regulator M654_RS18350 ENOG4105CBX hi0933 family M654_RS18355 ENOG4105C94 Transporter M654_RS18370 ENOG41085GJ domain protein M654_RS18385 ENOG4105MU9 integral membrane protein M654_RS18390 ENOG4105DDC Oxidoreductase domain protein M654_RS18400 ENOG4105F5H Glycosyl Hydrolase Family 88 M654_RS18410 ENOG41075H3 AraC family transcriptional regulator M654_RS18420 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component M654_RS18430 ENOG4105NTD Inherit from COG: Hydrolase M654_RS18440 ENOG4107V2S Transcriptional regulator M654_RS18445 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase M654_RS18450 ENOG4105C8T Leucyl-tRNA synthetase M654_RS18460 ENOG410605W Major Facilitator M654_RS18470 ENOG4106UBQ M654_RS18475 ENOG4107R34 abc transporter permease protein M654_RS18480 ENOG4105C19 ABC transporter M654_RS18495 ENOG4105WH1 Two component transcriptional regulator luxr family M654_RS18505 ENOG4107R34 abc transporter permease protein M654_RS18510 ENOG4105C19 ABC transporter M654_RS18520 ENOG4105DVE abc transporter atp-binding protein M654_RS18525 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family M654_RS18545 ENOG4108JJA ABC, transporter M654_RS18595 ENOG4105N5T Radical SAM Protein M654_RS18610 ENOG4105E8V Alpha Beta Hydrolase Fold protein M654_RS18615 ENOG4108Z0R Transferase M654_RS18620 ENOG4105YVM Phosphoesterase, PA-phosphatase related M654_RS18625 ENOG4105BZF Glycosyl transferase (Group 1 M654_RS18630 ENOG4105CAQ asparagine synthetase M654_RS18635 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP M654_RS18660 ENOG4105D2X ABC transporter substrate-binding protein M654_RS18670 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component M654_RS18690 ENOG4108RMU ferritin dps family protein M654_RS18705 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) M654_RS18710 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) M654_RS18715 ENOG4108V2W Carbonate dehydratase M654_RS18720 ENOG4105DSE periplasmic solute binding protein M654_RS18745 ENOG4105DTQ mandelate racemase muconate lactonizing M654_RS18750 ENOG4105CEY Amp-dependent synthetase and ligase M654_RS18755 ENOG4108IPT Naphthoate synthase M654_RS18760 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) M654_RS18765 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) M654_RS18770 ENOG4105E4F Isochorismate synthase M654_RS18775 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase M654_RS18790 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) M654_RS18800 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) M654_RS18805 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) M654_RS18915 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase M654_RS18975 ENOG4105TUA UPF0295 protein M654_RS18980 ENOG4105G5W regulator Fur family M654_RS18985 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M654_RS18990 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase M654_RS18995 ENOG4107NBY Membrane M654_RS19000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_RS19005 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_RS19010 ENOG4105DEF Extracellular solute-binding protein, family 5 M654_RS19015 ENOG4108JQ7 (ABC) transporter M654_RS19020 ENOG4105C3U ABC transporter M654_RS19025 ENOG4105BZ1 (ABC) transporter M654_RS19045 ENOG4105CAN Short-chain dehydrogenase reductase Sdr M654_RS19050 ENOG4106BXE M654_RS19055 ENOG4105CEN a g-specific adenine glycosylase M654_RS19060 ENOG41067AE Membrane-bound metal-dependent hydrolase M654_RS19065 ENOG4105EJV Membrane M654_RS19075 ENOG4105CKK Glycosyl transferase, family 2 M654_RS19080 ENOG4107VFR oxidoreductase M654_RS19105 ENOG410691R Modulates RecA activity (By similarity) M654_RS19110 ENOG4105ECP epimerase M654_RS19130 ENOG4107Y03 Nitroreductase M654_RS19135 ENOG4105JAB phenazine biosynthesis protein, phzf family M654_RS19165 ENOG4108DMH HTH_ARAC M654_RS19170 ENOG4105DSG hydrolase family 43 M654_RS19175 ENOG4105E4I Glycoside hydrolase family 28 M654_RS19180 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase M654_RS19190 ENOG4105KVH Transcriptional regulator M654_RS19200 ENOG4105CI1 PTS System M654_RS19205 ENOG4108Q3X Transcriptional regulator M654_RS19210 ENOG4105F8D glycoside hydrolase family 4 M654_RS19215 ENOG4105KK4 UPF0060 membrane protein M654_RS19220 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family M654_RS19230 ENOG4107QKR Dehydrogenase M654_RS19240 ENOG4107RUY (E1 component), alpha subunit M654_RS19250 ENOG4105GPN Uncharacterized conserved protein (DUF2294) M654_RS19255 ENOG4108TWJ NADH dehydrogenase subunit 5 M654_RS19260 ENOG4105EVH UPF0753 protein M654_RS19285 ENOG41079KZ Major Facilitator Superfamily M654_RS19310 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) M654_RS19320 ENOG4105D7N magnesium and cobalt transport protein CorA M654_RS19330 ENOG4105DCT glycerol dehydrogenase M654_RS19355 ENOG4105UPD Calcium Proton M654_RS19365 ENOG4108ISG Major Facilitator M654_RS19370 ENOG4107U9T Pfam:Ribonuclease_BN M654_RS19380 ENOG4105KJF protein tyrosine phosphatase M654_RS19385 ENOG4105BZG amino acid carrier protein M654_RS19395 ENOG4107RKG DJ-1/PfpI family M654_RS19400 ENOG4105CGH 5'-nucleotidase M654_RS19405 ENOG4108RCM Nitroreductase M654_RS19410 ENOG4105KVH Transcriptional regulator M654_RS19420 ENOG4105KBX Transcriptional regulator, TetR family M654_RS19425 ENOG4105KPY Small multidrug resistance protein M654_RS19430 ENOG4105RXJ M654_RS19435 ENOG4107QQG Dehydrogenase M654_RS19450 ENOG4108DMA Nad-dependent epimerase dehydratase M654_RS19455 ENOG4105K64 Glycosyl transferase, family 2 M654_RS19460 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) M654_RS19465 ENOG410635A Membrane M654_RS19470 ENOG4107TVC Glycosyl transferase, family 2 M654_RS19475 ENOG4108SHN Glycosyl transferase, family 2 M654_RS19495 ENOG4107414 GntR family transcriptional regulator M654_RS19500 ENOG4105CG3 alpha amylase, catalytic region M654_RS19505 ENOG4105C5Y PTS System M654_RS19530 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) M654_RS19540 ENOG4108RPX mosc domain containing protein M654_RS19545 ENOG410855V Acylphosphatase M654_RS19550 ENOG41082BM Transcriptional regulator, arsr family M654_RS19585 ENOG4107QPK )-transporter M654_RS19600 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein M654_RS19605 ENOG4105FDU atp-dependent rna helicase M654_RS19610 ENOG4105C5H ABC transporter M654_RS19615 ENOG4105DXB Major Facilitator superfamily M654_RS19620 ENOG4107SWG transcriptional regulator MERR family M654_RS19630 ENOG4106A3M Cytochrome p-450 M654_RS19635 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) M654_RS19645 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) M654_RS19650 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) M654_RS19655 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) M654_RS19660 ENOG4105CKI cobalamin synthesis protein M654_RS19670 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase M654_RS19675 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) M654_RS19685 ENOG41090KR LysR family transcriptional Regulator M654_RS19690 ENOG4105C5H ABC transporter M654_RS19695 ENOG4105C8P )-transporter M654_RS19700 ENOG4105FKZ Methyl-accepting chemotaxis M654_RS19705 ENOG4105C26 Dehydrogenase M654_RS19715 ENOG4105CDY transcriptional regulatory protein M654_RS19720 ENOG4108PCN EamA-like transporter family M654_RS19740 ENOG410780I phosphoprotein phosphatase activity M654_RS19790 ENOG4108HFV M654_RS19820 ENOG4107EV6 Inherit from COG: YD repeat protein M654_RS19890 ENOG4105QBX endodeoxyribonuclease RusA M654_RS19900 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) M654_RS19905 ENOG4105CBD Diacylglycerol kinase M654_RS19910 ENOG4105DU0 nucleoside hydrolase M654_RS19915 ENOG4105D9U N-acetyltransferase M654_RS19925 ENOG4108IG5 Transcriptional regulator M654_RS19935 ENOG4105D3P Mannan endo-1,4-beta-mannosidase M654_RS19940 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) M654_RS19945 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) M654_RS19950 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) M654_RS19955 ENOG4105CK7 Sodium proline symporter M654_RS19965 ENOG4105KT7 mgtC SapB transporter M654_RS19975 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) M654_RS19980 ENOG4105C4R Atp-dependent dna helicase M654_RS19990 ENOG4105KGF protein, YerC YecD M654_RS19995 ENOG4108R5T secreted protein M654_RS20010 ENOG4106A3M Cytochrome p-450 M654_RS20020 ENOG4105C12 Phosphoribosylglycinamide synthetase M654_RS20025 ENOG4105DC1 bifunctional purine biosynthesis protein purh M654_RS20030 ENOG4108V3E phosphoribosylglycinamide formyltransferase M654_RS20035 ENOG4105CXB phosphoribosylaminoimidazole synthetase M654_RS20045 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii M654_RS20055 ENOG4105VR9 phosphoribosylformylglycinamidine synthase M654_RS20060 ENOG4105C8V SAICAR synthetase M654_RS20065 ENOG4105C83 adenylosuccinate lyase M654_RS20070 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit M654_RS20075 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) M654_RS20085 ENOG4108U5N UPF0316 protein M654_RS20095 ENOG4105C7N Xanthine uracil vitamin C permease M654_RS20100 ENOG4105E5W Transporter M654_RS20125 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) M654_RS20140 ENOG4105C7R Atpase associated with various cellular activities aaa_3 M654_RS20155 ENOG4107STQ Multicopper oxidase M654_RS20160 ENOG4105UEI Transcriptional Regulator AraC Family M654_RS20205 ENOG4107URF beta-phospho-glucomutase M654_RS20210 ENOG4105CG3 alpha amylase, catalytic region M654_RS20225 ENOG4105EG2 ABC transporter, permease M654_RS20230 ENOG4105D56 permease protein M654_RS20235 ENOG4107FKK extracellular solute-binding protein family 1 M654_RS20240 ENOG4108IUK alpha amylase, catalytic M654_RS20245 ENOG4105FKQ transcriptional regulator M654_RS20250 ENOG4105E5K Alpha-amylase M654_RS20255 ENOG4108ZJ4 polysaccharide deacetylase M654_RS20275 ENOG4105N14 lysine exporter protein LysE YggA M654_RS20280 ENOG4108NGU Transcriptional regulator M654_RS20295 ENOG4105EBR Carboxylesterase M654_RS20300 ENOG4108VHC Short-chain dehydrogenase reductase Sdr M654_RS20305 ENOG4105K78 MarR family Transcriptional regulator M654_RS20315 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) M654_RS20320 ENOG4108X07 Tetr family transcriptional regulator M654_RS20335 ENOG4108RAV Conserved protein M654_RS20350 ENOG4108E16 pectate lyase M654_RS20365 ENOG4107TCE N-acetyltransferase M654_RS20385 ENOG4108HKT sucrose-6-phosphate hydrolase M654_RS20390 ENOG4105EDQ levansucrase EC 2.4.1.10 M654_RS20400 ENOG4105EQD regulatoR M654_RS20405 ENOG4105C2F Histidine kinase M654_RS20410 ENOG4107RHR regulatoR M654_RS20415 ENOG4105VI0 Pts system, glucitol sorbitol-specific M654_RS20420 ENOG4105DZY Pts system, glucitol sorbitol-specific M654_RS20425 ENOG410787A Pts system, glucitol sorbitol-specific M654_RS20450 ENOG4105CBT Fructose-1,6-bisphosphatase M654_RS20455 ENOG4108YZG isomerase M654_RS20460 ENOG4105E98 transcriptional regulator DeoR family M654_RS20475 ENOG4105CG6 trap dicarboxylate transporter dctm subunit M654_RS20480 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter M654_RS20485 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit M654_RS20490 ENOG4108KFM Xylose Isomerase Domain-Containing protein M654_RS20495 ENOG4105CHR reductase M654_RS20500 ENOG4105ETE Transcriptional regulator (LacI family M654_RS20505 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) M654_RS20510 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) M654_RS20515 ENOG4108TYN CAAX amino terminal protease family protein M654_RS20530 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) M654_RS20535 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) M654_RS20545 ENOG4105C5H ABC transporter M654_RS20550 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) M654_RS20555 ENOG410801F ribosomal-protein-alanine acetyltransferase M654_RS20560 ENOG41072GX Peptidase M22 Glycoprotease M654_RS20565 ENOG4105K8N protein family UPF0079, ATPase M654_RS20570 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) M654_RS20620 ENOG4108Z6X (sortase) family M654_RS20630 ENOG4108NEV two component transcriptional regulator, LytTR family M654_RS20640 ENOG4105C2C drug resistance transporter, Bcr CflA M654_RS20645 ENOG4105QV4 Tryptophan halogenase M654_RS20655 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) M654_RS20660 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) M654_RS20665 ENOG4107RHR regulatoR M654_RS20670 ENOG4105EXC Acyl-transferase M654_RS20680 ENOG4105X5K response regulator receiver protein M654_RS20690 ENOG4105CHR reductase M654_RS20695 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) M654_RS20710 ENOG4105C85 amino acid M654_RS20715 ENOG4107XCH Cyclase family M654_RS20730 ENOG4107RSM transcriptional regulator M654_RS20735 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase M654_RS20740 ENOG41090E6 transcriptional regulator MERR family M654_RS20755 ENOG4105CZ9 Domain of unknown function (DU1801) M654_RS20760 ENOG41082YX Transcriptional regulator, arsr family M654_RS20770 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 M654_RS20775 ENOG4108U05 Transcriptional regulator M654_RS20785 ENOG4107T94 Endo-14-beta-xylanase M654_RS20845 ENOG41064BQ Phosphatase M654_RS20865 ENOG4107SGM protein serine threonine phosphatase M654_RS20870 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase M654_RS20875 ENOG4105FUA antagonist M654_RS20880 ENOG4107MMM Anti-sigma-factor antagonist M654_RS20885 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) M654_RS20895 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) M654_RS20900 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein M654_RS20910 ENOG4105CKV Membrane M654_RS20915 ENOG410905X membrane-flanked domain protein M654_RS20920 ENOG4105C1J atp-dependent rna helicase M654_RS20930 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) M654_RS20935 ENOG4105CPF Cell wall formation (By similarity) M654_RS20940 ENOG4105SZ6 Thioredoxin M654_RS20955 ENOG4105FDT acyl-CoA dehydrogenase M654_RS20970 ENOG4105CJ1 ABC, transporter M654_RS20975 ENOG4105CK2 sodium dicarboxylate symporter M654_RS20980 ENOG4106F5Q Membrane M654_RS20985 ENOG4105QVS general stress protein M654_RS20990 ENOG41082W1 Cupin 2, conserved barrel domain protein M654_RS21000 ENOG4105EC3 peptidase S51, dipeptidase E M654_RS21005 ENOG4105EU9 M654_RS21015 ENOG41087PP glycosyltransferase MGT family M654_RS21020 ENOG4108IJ0 Aspartate ammonia-lyase M654_RS21025 ENOG4107BMA Transglycosylase associated protein M654_RS21030 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) M654_RS21055 ENOG4105C9U ATP-dependent DNA helicase RecQ M654_RS21070 ENOG4105VCH membrane M654_RS21075 ENOG4108RCF TRANSCRIPTIONal M654_RS21085 ENOG410606W general stress protein M654_RS21100 ENOG4105CYX Short-chain dehydrogenase reductase Sdr M654_RS21105 ENOG4105ETD TRANSCRIPTIONal M654_RS21110 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase M654_RS21125 ENOG4105XJB lipolytic protein G-D-S-L family M654_RS21130 ENOG4107258 Transcriptional regulator M654_RS21140 ENOG4105P4J Allophanate hydrolase, subunit 1 M654_RS21145 ENOG4105CFM UPF0317 protein M654_RS21150 ENOG4105C5A transporter M654_RS21155 ENOG4105E7W lamb ycsf family protein M654_RS21190 ENOG4107TXC Transcriptional regulator M654_RS21195 ENOG4105C8P )-transporter M654_RS21200 ENOG4105DRR Transcriptional regulator, GntR family M654_RS21210 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) M654_RS21215 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit M654_RS21220 ENOG4108IFG nitrite reductase, (NAD(P)H) M654_RS21225 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) M654_RS21235 ENOG4108ZYE Transcriptional regulator M654_RS21240 ENOG4108T5E Copper resistance protein M654_RS21245 ENOG4105KTB nuclear export factor GLE1 M654_RS21255 ENOG4108RNG Permease of the drug metabolite transporter M654_RS21260 ENOG4105EMU Dehydrogenase M654_RS21265 ENOG4105C26 Dehydrogenase M654_RS21270 ENOG4107QTZ amino acid M654_RS21275 ENOG4108JPW Aminotransferase M654_RS21285 ENOG4105YVS arsR family transcriptional regulator M654_RS21290 ENOG41067V3 Antibiotic biosynthesis monooxygenase M654_RS21295 ENOG4108DBC nitroreductase M654_RS21300 ENOG4105R8C Transcriptional regulator M654_RS21315 ENOG4108RZ2 Glycoside hydrolase family 16 M654_RS21330 ENOG4108IPW abc transporter atp-binding protein M654_RS21335 ENOG4105CM4 permease protein M654_RS21340 ENOG4105DHS permease protein M654_RS21345 ENOG4105CFH Aspartokinase M654_RS21350 ENOG4105EC8 Methyl-accepting chemotaxis M654_RS21355 ENOG4105BZU Histidine kinase M654_RS21360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_RS21365 ENOG4107WD8 ABC transporter, permease M654_RS21380 ENOG4107TXC Transcriptional regulator M654_RS21395 ENOG4105E1K spore germination protein M654_RS21410 ENOG4105DUX Transporter M654_RS21420 ENOG4107T32 3-phytase (EC 3.1.3.8) M654_RS21425 ENOG4105C4C beta-galactosidase M654_RS21430 ENOG410645S MarR family Transcriptional regulator M654_RS21435 ENOG4105DCM major facilitator superfamily M654_RS21445 ENOG4108HWW ABC transporter M654_RS21455 ENOG4105DFW ABC transporter M654_RS21460 ENOG4105EQD regulatoR M654_RS21465 ENOG4105C2F Histidine kinase M654_RS21535 ENOG41069ZX M654_RS21540 ENOG41069ZX M654_RS21545 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) M654_RS21550 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase M654_RS21555 ENOG4106P55 Transcriptional regulator M654_RS21560 ENOG41066UZ arginase EC 3.5.3.1 M654_RS21565 ENOG4108IQI permease M654_RS21570 ENOG4105C8Y Acetylornithine aminotransferase M654_RS21575 ENOG4108JUB Transcriptional regulator M654_RS21585 ENOG4105DRP amino acid AbC transporter M654_RS21590 ENOG4105CDA abc transporter atp-binding protein M654_RS21600 ENOG41067SE Tetr family transcriptional regulator M654_RS21650 ENOG41086D8 Transcriptional regulator M654_RS21655 ENOG4108SA1 esterase M654_RS21660 ENOG4105W8Z 4'-phosphopantetheinyl transferase M654_RS21670 ENOG4105SX7 Transporter M654_RS21690 ENOG4105CEY Amp-dependent synthetase and ligase M654_RS21695 ENOG4105D94 Major Facilitator Superfamily M654_RS21705 ENOG4105F38 ABC transporter, permease M654_RS21715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M654_RS21745 ENOG4105C8Q Methyl-accepting chemotaxis M654_RS21755 ENOG4108V5V Serine Threonine protein kinase M654_RS21760 ENOG4105CS2 ec 3.2.1.21 M654_RS21775 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein M654_RS21780 ENOG4105E5Q amino acid AbC transporter M654_RS21795 ENOG4105I82 acetyl xylan esterase M654_RS21800 ENOG4108PJD permease M654_RS21810 ENOG4107YHD transcriptional regulator M654_RS21815 ENOG4105CK7 Sodium proline symporter M654_RS21820 ENOG4105C26 Dehydrogenase M654_RS21830 ENOG410756H nucleotidyltransferase M654_RS21840 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) M654_RS21880 ENOG4107QIV Cytochrome c biogenesis protein M654_RS21890 ENOG4108TTB tellurium resistance protein M654_RS21905 ENOG4105DAX Pfam:DUF2983 M654_RS21920 ENOG4107TS3 membrane protein, TerC M654_RS21925 ENOG4106FN3 tellurium resistance protein M654_RS21930 ENOG4106FN3 tellurium resistance protein M654_RS21935 ENOG4108N0M stress protein M654_RS21960 ENOG4105CIG ABC transporter M654_RS21970 ENOG4105Z8B NlpC/P60 family M654_RS21975 ENOG4105DEN Luciferase family M654_RS21985 ENOG4105KHC sulfurtransferase M654_RS21995 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases M654_RS22010 ENOG410901P UPF0249 protein M654_RS22020 ENOG4105F8D glycoside hydrolase family 4 M654_RS22025 ENOG4105CK1 PTS System M654_RS22030 ENOG4105VCP PTS System M654_RS22040 ENOG4105CQB FAD linked oxidase domain protein M654_RS22045 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) M654_RS22050 ENOG41066YJ Beta-lactamase M654_RS22055 ENOG4107BMA Transglycosylase associated protein M654_RS22060 ENOG4105DPN Oligoendopeptidase f M654_RS22070 ENOG4108W0I acetyltransferase M654_RS22075 ENOG4107RB3 L-asparaginase M654_RS22105 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) M654_RS22125 ENOG4105MDS 4-oxalocrotonate tautomerase M654_RS22130 ENOG4107V2S Transcriptional regulator M654_RS22155 ENOG4105DA5 (ABC) transporter M654_RS22165 ENOG41060AI SEC-C motif M654_RS22175 ENOG4106UX7 integral membrane protein M654_RS22190 ENOG4107TXC Transcriptional regulator M654_RS22220 ENOG41067TZ transcriptional regulator, MarR family M654_RS22265 ENOG4108R1P M654_RS22275 ENOG4106FGC M654_RS22300 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_RS22305 ENOG4105CTX dehydratase M654_RS22310 ENOG41073TP transcriptional regulator M654_RS22315 ENOG4105EQX glucarate dehydratase M654_RS22320 ENOG4105DJB Major Facilitator Superfamily M654_RS22325 ENOG4105C26 Dehydrogenase M654_RS22330 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase M654_RS22335 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) M654_RS22340 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) M654_RS22345 ENOG4105DGI Alkaline phosphatase M654_RS22355 ENOG4105NA0 Transcriptional regulator M654_RS22365 ENOG4105KNA -acetyltransferase M654_RS22380 ENOG4105CSV Glutaminase M654_RS22390 ENOG4105MUA Resistance protein M654_RS22405 ENOG4108QY0 Membrane M654_RS22420 ENOG4105CI1 PTS System M654_RS22425 ENOG410901P UPF0249 protein M654_RS22430 ENOG4108J5H Homocysteine s-methyltransferase M654_RS22435 ENOG4108IQI permease M654_RS22440 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid M654_RS22455 ENOG4105DFW ABC transporter M654_RS22460 ENOG4105C8Q Methyl-accepting chemotaxis M654_RS22465 ENOG4107SCQ Iron-containing alcohol dehydrogenase M654_RS22500 ENOG4106AXJ AraC family transcriptional regulator M654_RS22505 ENOG410631K Membrane M654_RS22535 ENOG4107I77 yiaA/B two helix domain M654_RS22555 ENOG4105EYF MMPL domain protein M654_RS22560 ENOG41062A4 Transcriptional regulator M654_RS22575 ENOG4105DRR Transcriptional regulator, GntR family M654_RS22580 ENOG4108TVJ Nitroreductase M654_RS22585 ENOG4105DY8 decarboxylase M654_RS22630 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M654_RS22635 ENOG4105K4H Nlp p60 protein M654_RS22660 ENOG4105KVH Transcriptional regulator M654_RS22665 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein M654_RS22670 ENOG41087NI Sulfite exporter TauE/SafE M654_RS22675 ENOG4105VFE sira family M654_RS22680 ENOG4107TPS domain protein M654_RS22695 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase M654_RS22700 ENOG4105XTG Pfam:DUF156 M654_RS22710 ENOG4105C7Z Conserved Protein M654_RS22720 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M654_RS22730 ENOG4105C7Z Conserved Protein M654_RS22750 ENOG4106DDH Sporulation-specific SASP protein M654_RS22755 ENOG4105E5W Transporter M654_RS22770 ENOG4105IE8 Alpha-ketoglutarate permease M654_RS22775 ENOG4105CTS PTS system mannitol-specific M654_RS22780 ENOG4105ETD TRANSCRIPTIONal M654_RS22785 ENOG4105CPQ Dehydrogenase M654_RS22810 ENOG4105DDN Pentapeptide repeat-containing protein M654_RS22815 ENOG4105CG9 aspartate racemase M654_RS22830 ENOG4107ZXU DSBA oxidoreductase M654_RS22835 ENOG4105BZ1 (ABC) transporter M654_RS22860 ENOG4105DA5 (ABC) transporter M654_RS22870 ENOG4108RWP Major Facilitator Superfamily protein M654_RS22875 ENOG4105WAB arsR family transcriptional regulator M654_RS22885 ENOG4105KVH Transcriptional regulator M654_RS22890 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein M654_RS22905 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) M654_RS22910 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) M654_RS22915 ENOG4107U5W ybbr family M654_RS22920 ENOG4105C8B TIGR00159 family M654_RS22930 ENOG4105EMN RNA polymerase sigma factor M654_RS22965 ENOG4105EWC Purine nucleoside phosphorylase M654_RS22970 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate M654_RS22990 ENOG4105D17 glycoside hydrolase, family 3 domain protein M654_RS22995 ENOG4105EHZ conserved protein UCP016719 M654_RS23000 ENOG4105JAB phenazine biosynthesis protein, phzf family M654_RS23020 ENOG4108A04 Beta-lactamase M654_RS23065 ENOG4108NMV polysaccharide deacetylase M654_RS23080 ENOG4105D1F ATP-binding protein M654_RS23100 ENOG4108UJD 30S ribosomal protein S9 M654_RS23105 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) M654_RS23110 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) M654_RS23115 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) M654_RS23120 ENOG4108JJB ABC transporter M654_RS23125 ENOG4108JJB ABC transporter M654_RS23130 ENOG4108ZT0 50S ribosomal protein l17 M654_RS23135 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) M654_RS23140 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) M654_RS23145 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits M654_RS23150 ENOG41067V7 50S ribosomal protein L36 M654_RS23155 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) M654_RS23165 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) M654_RS23170 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) M654_RS23175 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) M654_RS23180 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) M654_RS23190 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) M654_RS23195 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) M654_RS23200 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) M654_RS23205 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) M654_RS23210 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) M654_RS23215 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits M654_RS23220 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) M654_RS23225 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) M654_RS23230 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal M654_RS23235 ENOG41082SA 50s ribosomal protein l29 M654_RS23240 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) M654_RS23245 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) M654_RS23250 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) M654_RS23255 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) M654_RS23260 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity M654_RS23265 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) M654_RS23270 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) M654_RS23275 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) M654_RS23280 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) M654_RS23285 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) M654_RS23290 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) M654_RS23295 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) M654_RS23300 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) M654_RS23305 ENOG4105XPM ribosomal protein M654_RS23310 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) M654_RS23315 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) M654_RS23320 ENOG4107Y49 methyltransferase M654_RS23325 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) M654_RS23330 ENOG4108VZM 50s ribosomal protein L10 M654_RS23335 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) M654_RS23340 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) M654_RS23345 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) M654_RS23350 ENOG410683Z Preprotein translocase SecE subunit M654_RS23360 ENOG4105QIV RNA polymerase M654_RS23365 ENOG4105M0M Tetracycline resistance protein M654_RS23370 ENOG4105C2N RNA methyltransferase TrmH family group 3 M654_RS23375 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) M654_RS23380 ENOG4105C8N cysteinyl-tRNA synthetase M654_RS23385 ENOG4105D7W serine acetyltransferase M654_RS23390 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) M654_RS23395 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) M654_RS23400 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) M654_RS23405 ENOG4105CTP PilT protein domain protein M654_RS23410 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) M654_RS23415 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) M654_RS23425 ENOG41066A3 ATP guanido phosphotransferase M654_RS23430 ENOG4108Z0C Uvrb UvrC protein