locus-tag	class	description
H7F24_RS00010	COG1575	Belongs to the MenA family. Type 1 subfamily
H7F24_RS00015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7F24_RS00145	COG3859	Proton-coupled thiamine transporter YuaJ
H7F24_RS00155	COG1247	-acetyltransferase
H7F24_RS00160	COG3339	Conserved Protein
H7F24_RS00165	COG0772	Belongs to the SEDS family
H7F24_RS00170	COG0772	Belongs to the SEDS family
H7F24_RS00175	COG2268	Band 7 protein
H7F24_RS00180	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7F24_RS00185	COG2318	DinB family
H7F24_RS00190	COG1454	alcohol dehydrogenase
H7F24_RS00195	COG1012	belongs to the aldehyde dehydrogenase family
H7F24_RS00200	COG1510	regulation of RNA biosynthetic process
H7F24_RS00225	COG3409	Peptidoglycan-binding domain 1 protein
H7F24_RS00225	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS00280	COG3778	Protein conserved in bacteria
H7F24_RS00285	COG3299	homolog of phage Mu protein gp47
H7F24_RS00290	COG3628	GPW Gp25 family protein
H7F24_RS00300	COG4193	domain, Protein
H7F24_RS00305	COG1652	LysM domain
H7F24_RS00310	COG3953	SLT domain
H7F24_RS00310	COG5280	Phage tail tape measure protein TP901
H7F24_RS00310	COG3953	SLT domain
H7F24_RS00310	COG5280	Phage tail tape measure protein TP901
H7F24_RS00365	COG4653	Phage capsid family
H7F24_RS00370	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7F24_RS00375	COG5518	Phage portal protein
H7F24_RS00380	COG1783	phage Terminase large subunit
H7F24_RS00385	COG5484	DNA packaging
H7F24_RS00390	COG1595	DNA-templated transcription, initiation
H7F24_RS00400	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
H7F24_RS00420	COG1396	sequence-specific DNA binding
H7F24_RS00430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7F24_RS00440	COG1968	undecaprenyl-diphosphatase activity
H7F24_RS00445	COG0628	permease
H7F24_RS00455	COG0673	inositol 2-dehydrogenase activity
H7F24_RS00460	COG0693	protein deglycase activity
H7F24_RS00465	COG0840	transmembrane signaling receptor activity
H7F24_RS00470	COG0840	transmembrane signaling receptor activity
H7F24_RS00475	COG0840	transmembrane signaling receptor activity
H7F24_RS00480	COG0840	transmembrane signaling receptor activity
H7F24_RS00495	COG2070	2-Nitropropane dioxygenase
H7F24_RS00500	COG0432	Pfam Uncharacterised protein family UPF0047
H7F24_RS00505	COG1253	flavin adenine dinucleotide binding
H7F24_RS00510	COG2738	Putative neutral zinc metallopeptidase
H7F24_RS00520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7F24_RS00535	COG0166	Belongs to the GPI family
H7F24_RS00540	COG1979	alcohol dehydrogenase
H7F24_RS00545	COG1979	alcohol dehydrogenase
H7F24_RS00550	COG2155	Conserved Protein
H7F24_RS00555	COG1098	S1 RNA binding domain
H7F24_RS00560	COG0436	Aminotransferase
H7F24_RS00565	COG1522	sequence-specific DNA binding
H7F24_RS00570	COG2267	carboxylic ester hydrolase activity
H7F24_RS00580	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7F24_RS00585	COG2205	protein histidine kinase activity
H7F24_RS00600	COG5018	Exonuclease
H7F24_RS00605	COG2814	Major facilitator Superfamily
H7F24_RS00610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F24_RS00615	COG3011	Protein conserved in bacteria
H7F24_RS00625	COG3290	protein histidine kinase activity
H7F24_RS00630	COG4565	transcriptional regulatory protein
H7F24_RS00635	COG1744	ABC transporter substrate-binding protein PnrA-like
H7F24_RS00640	COG3845	ABC transporter
H7F24_RS00645	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7F24_RS00650	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7F24_RS00655	COG3493	citrate carrier protein
H7F24_RS00665	COG2111	Na H antiporter
H7F24_RS00665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7F24_RS00670	COG2111	Na H antiporter
H7F24_RS00675	COG1006	Multisubunit Na H antiporter MnhC subunit
H7F24_RS00680	COG0651	ATP synthesis coupled electron transport
H7F24_RS00685	COG1863	multisubunit Na H antiporter MnhE subunit
H7F24_RS00690	COG2212	antiporter activity
H7F24_RS00695	COG1320	monovalent cation:proton antiporter activity
H7F24_RS00700	COG2050	protein possibly involved in aromatic compounds catabolism
H7F24_RS00705	COG2197	response regulator
H7F24_RS00710	COG4585	Histidine kinase
H7F24_RS00720	COG0142	geranyltranstransferase activity
H7F24_RS00735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7F24_RS00740	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7F24_RS00745	COG1335	isochorismatase
H7F24_RS00750	COG5506	Protein of unknown function (DUF1694)
H7F24_RS00770	COG0628	permease
H7F24_RS00785	COG1418	mRNA catabolic process
H7F24_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS00800	COG1511	domain protein
H7F24_RS00805	COG0433	COG0433 Predicted ATPase
H7F24_RS00805	COG1674	ftsk spoiiie
H7F24_RS00810	COG4499	WXG100 protein secretion system (Wss), protein YukC
H7F24_RS00815	COG5417	Belongs to the EsaB family
H7F24_RS00820	COG4842	Belongs to the WXG100 family
H7F24_RS00825	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H7F24_RS00825	COG2508	Transcriptional regulator
H7F24_RS00830	COG0686	Belongs to the AlaDH PNT family
H7F24_RS00835	COG1268	BioY protein
H7F24_RS00840	COG4326	sporulation control protein
H7F24_RS00845	COG2056	Na+-H+ antiporter family
H7F24_RS00850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7F24_RS00855	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H7F24_RS00860	COG3584	3D domain protein
H7F24_RS00875	COG1252	NADH dehydrogenase
H7F24_RS00880	COG0492	ferredoxin-NADP+ reductase activity
H7F24_RS00890	COG0789	Transcriptional regulator
H7F24_RS00895	COG0316	Belongs to the HesB IscA family
H7F24_RS00900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7F24_RS00905	COG4844	belongs to the
H7F24_RS00910	COG1252	NADH dehydrogenase
H7F24_RS00920	COG4837	Protein of unknown function (DUF1462)
H7F24_RS00925	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7F24_RS00930	COG4946	Tricorn protease homolog
H7F24_RS00930	COG1506	peptidase
H7F24_RS00930	COG0823	Involved in the tonB-independent uptake of proteins
H7F24_RS00935	COG0083	homoserine kinase activity
H7F24_RS00940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7F24_RS00945	COG0460	homoserine dehydrogenase
H7F24_RS00950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F24_RS00955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7F24_RS00960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7F24_RS00965	COG0647	UMP catabolic process
H7F24_RS00970	COG2445	Protein of unknown function DUF86
H7F24_RS00975	COG4470	Protein conserved in bacteria
H7F24_RS00985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7F24_RS00990	COG0739	heme binding
H7F24_RS01000	COG3377	Domain of unknown function (DUF1805)
H7F24_RS01005	COG0737	Belongs to the 5'-nucleotidase family
H7F24_RS01010	COG1801	Protein of unknown function DUF72
H7F24_RS01015	COG2508	Transcriptional regulator
H7F24_RS01020	COG2140	Oxalate decarboxylase
H7F24_RS01025	COG2814	Major facilitator Superfamily
H7F24_RS01030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7F24_RS01035	COG2356	endonuclease I
H7F24_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F24_RS01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F24_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F24_RS01065	COG0561	phosphatase activity
H7F24_RS01075	COG0642	Histidine kinase
H7F24_RS01075	COG5002	protein histidine kinase activity
H7F24_RS01080	COG0745	RESPONSE REGULATOR receiver
H7F24_RS01085	COG2311	Membrane
H7F24_RS01095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7F24_RS01105	COG1309	transcriptional regulator
H7F24_RS01110	COG0719	Fe-S assembly protein
H7F24_RS01115	COG0822	iron-sulfur transferase activity
H7F24_RS01120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7F24_RS01125	COG0719	Fe-S assembly protein
H7F24_RS01130	COG0396	ATPase activity
H7F24_RS01135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7F24_RS01140	COG1464	Belongs to the NlpA lipoprotein family
H7F24_RS01145	COG2011	ABC-type metal ion transport system permease component
H7F24_RS01150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7F24_RS01160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F24_RS01165	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H7F24_RS01175	COG0509	glycine decarboxylation via glycine cleavage system
H7F24_RS01180	COG1393	Belongs to the ArsC family
H7F24_RS01185	COG1960	acyl-CoA dehydrogenase activity
H7F24_RS01190	COG0183	Belongs to the thiolase family
H7F24_RS01195	COG1024	Enoyl-CoA hydratase
H7F24_RS01195	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F24_RS01210	COG5577	PFAM Coat F domain
H7F24_RS01220	COG1120	ATPase activity
H7F24_RS01230	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS01235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F24_RS01240	COG0745	RESPONSE REGULATOR receiver
H7F24_RS01245	COG2205	protein histidine kinase activity
H7F24_RS01245	COG2770	Histidine kinase
H7F24_RS01255	COG1309	transcriptional regulator
H7F24_RS01265	COG0114	fumarate hydratase activity
H7F24_RS01275	COG0697	spore germination
H7F24_RS01280	COG0814	amino acid
H7F24_RS01295	COG2197	response regulator
H7F24_RS01300	COG4585	Histidine kinase
H7F24_RS01305	COG4758	membrane
H7F24_RS01315	COG1842	Phage shock protein A
H7F24_RS01320	COG4758	membrane
H7F24_RS01325	COG2096	Adenosyltransferase
H7F24_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS01335	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7F24_RS01345	COG2204	response regulator
H7F24_RS01360	COG1454	alcohol dehydrogenase
H7F24_RS01365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7F24_RS01375	COG1120	ATPase activity
H7F24_RS01380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F24_RS01385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F24_RS01395	COG2721	sulfolactate sulfo-lyase activity
H7F24_RS01400	COG0246	Mannitol dehydrogenase
H7F24_RS01405	COG1609	Transcriptional regulator
H7F24_RS01410	COG1904	glucuronate isomerase
H7F24_RS01415	COG2205	protein histidine kinase activity
H7F24_RS01420	COG0745	RESPONSE REGULATOR receiver
H7F24_RS01425	COG1120	ATPase activity
H7F24_RS01430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F24_RS01435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F24_RS01440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F24_RS01445	COG0531	amino acid
H7F24_RS01460	COG1988	membrane-bound metal-dependent
H7F24_RS01465	COG1368	sulfuric ester hydrolase activity
H7F24_RS01470	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7F24_RS01475	COG4149	molybdate abc transporter
H7F24_RS01480	COG0656	L-ascorbic acid biosynthetic process
H7F24_RS01485	COG1940	carbohydrate kinase activity
H7F24_RS01490	COG0025	NhaP-type Na H and K H
H7F24_RS01495	COG2860	membrane
H7F24_RS01500	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7F24_RS01505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7F24_RS01510	COG2217	Heavy metal translocating P-type atpase
H7F24_RS01515	COG1121	(ABC) transporter
H7F24_RS01520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7F24_RS01525	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7F24_RS01535	COG3226	Transcriptional regulator
H7F24_RS01540	COG0784	Response regulator, receiver
H7F24_RS01545	COG4191	Histidine kinase
H7F24_RS01550	COG1027	Aspartate ammonia-lyase
H7F24_RS01560	COG2217	Heavy metal translocating P-type atpase
H7F24_RS01565	COG2608	mercury ion transmembrane transporter activity
H7F24_RS01570	COG1937	Protein conserved in bacteria
H7F24_RS01620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7F24_RS01625	COG0557	exoribonuclease II activity
H7F24_RS01630	COG1647	Serine aminopeptidase, S33
H7F24_RS01635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7F24_RS01640	COG2002	toxin-antitoxin pair type II binding
H7F24_RS01645	COG1476	TRANSCRIPTIONal
H7F24_RS01650	COG1396	sequence-specific DNA binding
H7F24_RS01655	COG1396	sequence-specific DNA binding
H7F24_RS01660	COG1733	regulation of RNA biosynthetic process
H7F24_RS01665	COG1174	glycine betaine transport
H7F24_RS01670	COG1732	Glycine betaine
H7F24_RS01675	COG1174	glycine betaine transport
H7F24_RS01680	COG1125	glycine betaine transport
H7F24_RS01680	COG0517	IMP dehydrogenase activity
H7F24_RS01685	COG1510	regulation of RNA biosynthetic process
H7F24_RS01690	COG2095	MarC family integral membrane protein
H7F24_RS01700	COG0456	acetyltransferase
H7F24_RS01720	COG1122	ATPase activity
H7F24_RS01730	COG0148	phosphopyruvate hydratase activity
H7F24_RS01735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7F24_RS01740	COG0149	triose-phosphate isomerase activity
H7F24_RS01745	COG0126	phosphoglycerate kinase activity
H7F24_RS01750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7F24_RS01755	COG2390	Transcriptional regulator
H7F24_RS01760	COG0833	amino acid
H7F24_RS01765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7F24_RS01770	COG3829	transcription factor binding
H7F24_RS01775	COG2186	Transcriptional regulator
H7F24_RS01780	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7F24_RS01790	COG0534	Mate efflux family protein
H7F24_RS01800	COG0444	Belongs to the ABC transporter superfamily
H7F24_RS01805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F24_RS01810	COG0601	transmembrane transport
H7F24_RS01815	COG0747	negative chemotaxis
H7F24_RS01820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F24_RS01825	COG0110	maltose O-acetyltransferase activity
H7F24_RS01830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7F24_RS01835	COG2244	polysaccharide biosynthetic process
H7F24_RS01840	COG5039	Polysaccharide pyruvyl transferase
H7F24_RS01845	COG1216	Glycosyl transferase, family 2
H7F24_RS01855	COG0438	transferase activity, transferring glycosyl groups
H7F24_RS01860	COG1215	transferase activity, transferring glycosyl groups
H7F24_RS01865	COG0438	transferase activity, transferring glycosyl groups
H7F24_RS01870	COG1086	Polysaccharide biosynthesis protein
H7F24_RS01875	COG0489	protein tyrosine kinase activity
H7F24_RS01880	COG3944	biosynthesis protein
H7F24_RS01885	COG1396	sequence-specific DNA binding
H7F24_RS01895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F24_RS01900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F24_RS01905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F24_RS01910	COG0726	polysaccharide deacetylase
H7F24_RS01915	COG0488	(ABC) transporter
H7F24_RS01935	COG0601	transmembrane transport
H7F24_RS01940	COG0747	negative chemotaxis
H7F24_RS01945	COG1819	glycosyl
H7F24_RS01960	COG0740	serine-type endopeptidase activity
H7F24_RS01965	COG1611	Belongs to the LOG family
H7F24_RS01970	COG1694	Mazg nucleotide pyrophosphohydrolase
H7F24_RS01975	COG0659	secondary active sulfate transmembrane transporter activity
H7F24_RS01980	COG0288	reversible hydration of carbon dioxide
H7F24_RS01985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F24_RS01995	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H7F24_RS02000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS02005	COG1481	regulation of sporulation
H7F24_RS02010	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H7F24_RS02015	COG1660	Displays ATPase and GTPase activities
H7F24_RS02020	COG1051	belongs to the nudix hydrolase family
H7F24_RS02025	COG0492	ferredoxin-NADP+ reductase activity
H7F24_RS02030	COG0791	NLP P60 protein
H7F24_RS02030	COG3883	PFAM NLP P60 protein
H7F24_RS02035	COG0457	Tetratricopeptide repeat
H7F24_RS02040	COG0140	phosphoribosyl-ATP diphosphatase activity
H7F24_RS02040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7F24_RS02045	COG0107	imidazoleglycerol-phosphate synthase activity
H7F24_RS02050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7F24_RS02055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7F24_RS02060	COG0131	Imidazoleglycerol-phosphate dehydratase
H7F24_RS02065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7F24_RS02070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7F24_RS02075	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H7F24_RS02080	COG4990	cell redox homeostasis
H7F24_RS02090	COG2910	NAD(P)H-binding
H7F24_RS02095	COG1959	2 iron, 2 sulfur cluster binding
H7F24_RS02100	COG0110	maltose O-acetyltransferase activity
H7F24_RS02105	COG0546	phosphoglycolate phosphatase activity
H7F24_RS02110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H7F24_RS02120	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H7F24_RS02125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7F24_RS02130	COG0363	glucosamine-6-phosphate deaminase activity
H7F24_RS02135	COG2188	Transcriptional regulator
H7F24_RS02140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H7F24_RS02145	COG1950	PFAM Membrane protein of
H7F24_RS02150	COG1983	PspC domain protein
H7F24_RS02155	COG3595	metallopeptidase activity
H7F24_RS02170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7F24_RS02180	COG4897	Protein conserved in bacteria
H7F24_RS02185	COG3848	Pyruvate phosphate dikinase
H7F24_RS02185	COG0574	Belongs to the PEP-utilizing enzyme family
H7F24_RS02190	COG1309	transcriptional regulator
H7F24_RS02195	COG2814	Major facilitator Superfamily
H7F24_RS02205	COG0745	RESPONSE REGULATOR receiver
H7F24_RS02210	COG5002	protein histidine kinase activity
H7F24_RS02215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7F24_RS02220	COG0463	Glycosyl transferase, family 2
H7F24_RS02225	COG1113	amino acid transport
H7F24_RS02230	COG0778	Nitroreductase
H7F24_RS02235	COG1733	regulation of RNA biosynthetic process
H7F24_RS02240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F24_RS02250	COG0793	Belongs to the peptidase S41A family
H7F24_RS02250	COG3409	Peptidoglycan-binding domain 1 protein
H7F24_RS02255	COG0730	response to heat
H7F24_RS02260	COG3883	PFAM NLP P60 protein
H7F24_RS02260	COG0791	NLP P60 protein
H7F24_RS02265	COG2177	Part of the ABC transporter FtsEX involved in
H7F24_RS02270	COG2884	Cell division ATP-binding protein ftsE
H7F24_RS02275	COG2010	Cytochrome c
H7F24_RS02280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F24_RS02300	COG0653	protein targeting
H7F24_RS02305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7F24_RS02310	COG0840	transmembrane signaling receptor activity
H7F24_RS02325	COG1516	flagellar protein fliS
H7F24_RS02330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7F24_RS02335	COG1334	flagellar protein FlaG
H7F24_RS02340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7F24_RS02345	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H7F24_RS02355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F24_RS02360	COG1256	bacterial-type flagellum assembly
H7F24_RS02360	COG4786	Flagellar basal body rod
H7F24_RS02365	COG3418	PFAM FlgN family protein
H7F24_RS02380	COG1040	competence protein
H7F24_RS02390	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H7F24_RS02395	COG1307	EDD domain protein, DegV family
H7F24_RS02400	COG2197	response regulator
H7F24_RS02405	COG4585	Histidine kinase
H7F24_RS02410	COG1739	Uncharacterized protein family UPF0029
H7F24_RS02415	COG1316	TRANSCRIPTIONal
H7F24_RS02420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7F24_RS02425	COG0438	transferase activity, transferring glycosyl groups
H7F24_RS02430	COG1215	transferase activity, transferring glycosyl groups
H7F24_RS02435	COG3206	protein involved in exopolysaccharide biosynthesis
H7F24_RS02440	COG3307	-O-antigen
H7F24_RS02445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F24_RS02450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7F24_RS02455	COG0297	glycogen (starch) synthase activity
H7F24_RS02455	COG0438	transferase activity, transferring glycosyl groups
H7F24_RS02460	COG2244	polysaccharide biosynthetic process
H7F24_RS02475	COG2247	cell wall binding repeat
H7F24_RS02475	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS02480	COG2247	cell wall binding repeat
H7F24_RS02480	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS02485	COG2247	cell wall binding repeat
H7F24_RS02485	COG2385	sporulation resulting in formation of a cellular spore
H7F24_RS02495	COG1316	TRANSCRIPTIONal
H7F24_RS02500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7F24_RS02505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7F24_RS02510	COG1134	teichoic acid transport
H7F24_RS02515	COG1682	transport, permease protein
H7F24_RS02525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F24_RS02535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7F24_RS02540	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H7F24_RS02545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F24_RS02550	COG4193	domain, Protein
H7F24_RS02555	COG1482	cell wall glycoprotein biosynthetic process
H7F24_RS02565	COG1175	transmembrane transport
H7F24_RS02570	COG1653	transport
H7F24_RS02575	COG2201	protein-glutamate methylesterase activity
H7F24_RS02580	COG2972	Histidine kinase
H7F24_RS02590	COG0454	-acetyltransferase
H7F24_RS02595	COG0800	Aldolase
H7F24_RS02600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F24_RS02605	COG1609	Transcriptional regulator
H7F24_RS02610	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H7F24_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS02620	COG0697	spore germination
H7F24_RS02625	COG0814	amino acid
H7F24_RS02640	COG2814	Major facilitator Superfamily
H7F24_RS02645	COG1316	TRANSCRIPTIONal
H7F24_RS02650	COG0561	phosphatase activity
H7F24_RS02655	COG0791	NLP P60 protein
H7F24_RS02665	COG2843	Capsule synthesis protein
H7F24_RS02675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7F24_RS02680	COG0697	spore germination
H7F24_RS02695	COG1609	Transcriptional regulator
H7F24_RS02700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F24_RS02705	COG1869	D-ribose catabolic process
H7F24_RS02710	COG1129	ABC transporter
H7F24_RS02715	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7F24_RS02720	COG1879	ABC-type sugar transport system periplasmic component
H7F24_RS02725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7F24_RS02730	COG0583	DNA-binding transcription factor activity
H7F24_RS02735	COG0028	Belongs to the TPP enzyme family
H7F24_RS02740	COG3527	Alpha-acetolactate decarboxylase
H7F24_RS02745	COG1522	sequence-specific DNA binding
H7F24_RS02750	COG2059	Chromate
H7F24_RS02755	COG2059	Chromate
H7F24_RS02760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7F24_RS02770	COG4715	Zinc finger, swim domain protein
H7F24_RS02775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7F24_RS02780	COG2202	Pas domain
H7F24_RS02780	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F24_RS02785	COG0561	phosphatase activity
H7F24_RS02800	COG1970	mechanosensitive ion channel activity
H7F24_RS02805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7F24_RS02810	COG0457	Tetratricopeptide repeat
H7F24_RS02815	COG4786	Flagellar basal body rod
H7F24_RS02820	COG4786	Flagellar basal body rod
H7F24_RS02825	COG1077	Cell shape determining protein MreB Mrl
H7F24_RS02830	COG1609	Transcriptional regulator
H7F24_RS02835	COG1846	Transcriptional regulator
H7F24_RS02840	COG2814	Major facilitator Superfamily
H7F24_RS02845	COG0671	phosphoesterase, PA-phosphatase related
H7F24_RS02850	COG0477	Major facilitator Superfamily
H7F24_RS02855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F24_RS02860	COG0765	amino acid transport
H7F24_RS02870	COG0004	ammonium transporteR
H7F24_RS02875	COG0347	Belongs to the P(II) protein family
H7F24_RS02880	COG0739	heme binding
H7F24_RS02885	COG1247	-acetyltransferase
H7F24_RS02925	COG0523	cobalamin synthesis protein
H7F24_RS02930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7F24_RS02935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7F24_RS02940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7F24_RS02945	COG2223	nitrite transmembrane transporter activity
H7F24_RS02950	COG0243	molybdopterin cofactor binding
H7F24_RS02955	COG2304	oxidoreductase activity
H7F24_RS02960	COG2304	oxidoreductase activity
H7F24_RS02965	COG2385	sporulation resulting in formation of a cellular spore
H7F24_RS02970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7F24_RS02980	COG4836	Membrane
H7F24_RS02990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7F24_RS02995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7F24_RS03000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7F24_RS03005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7F24_RS03010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7F24_RS03015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7F24_RS03020	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7F24_RS03025	COG0356	it plays a direct role in the translocation of protons across the membrane
H7F24_RS03035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7F24_RS03040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7F24_RS03045	COG4475	Protein of unknown function (DUF436)
H7F24_RS03050	COG0698	ribose 5-phosphate isomerase
H7F24_RS03055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7F24_RS03060	COG1971	Probably functions as a manganese efflux pump
H7F24_RS03065	COG0009	L-threonylcarbamoyladenylate synthase
H7F24_RS03070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7F24_RS03085	COG2890	protein-(glutamine-N5) methyltransferase activity
H7F24_RS03090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7F24_RS03095	COG0789	Transcriptional regulator
H7F24_RS03100	COG0679	Auxin Efflux Carrier
H7F24_RS03105	COG0281	malic enzyme
H7F24_RS03110	COG1435	thymidine kinase activity
H7F24_RS03115	COG0254	rRNA binding
H7F24_RS03120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H7F24_RS03125	COG1494	fructose-1,6-bisphosphatase
H7F24_RS03130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7F24_RS03135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7F24_RS03140	COG0191	fructose-bisphosphate aldolase activity
H7F24_RS03145	COG2204	response regulator
H7F24_RS03150	COG4821	SIS domain
H7F24_RS03155	COG0504	CTP synthase activity
H7F24_RS03160	COG3343	RNA polymerase activity
H7F24_RS03170	COG1960	acyl-CoA dehydrogenase activity
H7F24_RS03175	COG1960	acyl-CoA dehydrogenase activity
H7F24_RS03180	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F24_RS03185	COG0183	Belongs to the thiolase family
H7F24_RS03190	COG2181	nitrate reductase activity
H7F24_RS03190	COG0247	lactate metabolic process
H7F24_RS03195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F24_RS03200	COG4294	response to UV
H7F24_RS03210	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7F24_RS03215	COG1132	(ABC) transporter
H7F24_RS03220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F24_RS03225	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7F24_RS03230	COG0018	arginyl-trna synthetase
H7F24_RS03235	COG4506	Protein conserved in bacteria
H7F24_RS03245	COG0010	Belongs to the arginase family
H7F24_RS03250	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7F24_RS03255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F24_RS03265	COG1994	Peptidase M50
H7F24_RS03270	COG1942	4-Oxalocrotonate Tautomerase
H7F24_RS03280	COG3465	dGTPase activity
H7F24_RS03285	COG1078	dGTPase activity
H7F24_RS03290	COG4844	belongs to the
H7F24_RS03340	COG5444	nuclease activity
H7F24_RS03370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7F24_RS03380	COG0280	phosphate acetyltransferase
H7F24_RS03390	COG2814	Major facilitator Superfamily
H7F24_RS03395	COG1522	sequence-specific DNA binding
H7F24_RS03400	COG2814	Major facilitator Superfamily
H7F24_RS03405	COG0077	Prephenate dehydratase
H7F24_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS03420	COG0151	Belongs to the GarS family
H7F24_RS03425	COG0436	Aminotransferase
H7F24_RS03430	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS03435	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H7F24_RS03440	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7F24_RS03445	COG1088	dTDP-glucose 4,6-dehydratase activity
H7F24_RS03450	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7F24_RS03455	COG3980	spore coat polysaccharide biosynthesis protein
H7F24_RS03460	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
H7F24_RS03465	COG2089	acid synthase
H7F24_RS03470	COG0456	acetyltransferase
H7F24_RS03475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F24_RS03480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F24_RS03485	COG0463	Glycosyl transferase, family 2
H7F24_RS03505	COG2363	Small membrane protein
H7F24_RS03510	COG2233	PERMEase
H7F24_RS03520	COG1012	belongs to the aldehyde dehydrogenase family
H7F24_RS03525	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7F24_RS03530	COG1216	Glycosyl transferase, family 2
H7F24_RS03540	COG0351	phosphomethylpyrimidine kinase
H7F24_RS03560	COG3964	amidohydrolase
H7F24_RS03565	COG1621	beta-fructofuranosidase activity
H7F24_RS03570	COG1263	PTS System
H7F24_RS03570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS03575	COG3711	transcriptional antiterminator
H7F24_RS03585	COG1404	Belongs to the peptidase S8 family
H7F24_RS03590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F24_RS03595	COG0778	Nitroreductase
H7F24_RS03600	COG0772	Belongs to the SEDS family
H7F24_RS03610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7F24_RS03615	COG1845	cytochrome c oxidase, subunit III
H7F24_RS03620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7F24_RS03625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7F24_RS03635	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H7F24_RS03640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7F24_RS03645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7F24_RS03660	COG2246	polysaccharide biosynthetic process
H7F24_RS03680	COG3162	membrane
H7F24_RS03685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F24_RS03695	COG0352	thiamine-phosphate diphosphorylase activity
H7F24_RS03700	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H7F24_RS03705	COG0583	DNA-binding transcription factor activity
H7F24_RS03710	COG1380	Effector of murein hydrolase LrgA
H7F24_RS03715	COG1346	cytolysis
H7F24_RS03720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7F24_RS03725	COG0346	lactoylglutathione lyase activity
H7F24_RS03735	COG0765	amino acid transport
H7F24_RS03740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F24_RS03745	COG0457	Tetratricopeptide repeat
H7F24_RS03755	COG2357	RelA SpoT domain protein
H7F24_RS03760	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7F24_RS03765	COG1129	ABC transporter
H7F24_RS03775	COG3420	alginic acid biosynthetic process
H7F24_RS03780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F24_RS03790	COG1486	melibiose metabolic process
H7F24_RS03795	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7F24_RS03800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F24_RS03805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F24_RS03810	COG3711	transcriptional antiterminator
H7F24_RS03810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS03825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F24_RS03840	COG1595	DNA-templated transcription, initiation
H7F24_RS03850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7F24_RS03855	COG4988	ABC transporter
H7F24_RS03860	COG1294	oxidase, subunit
H7F24_RS03865	COG1271	oxidase subunit
H7F24_RS03885	COG4509	Sortase family
H7F24_RS03910	COG5386	Cell surface protein
H7F24_RS03915	COG5386	Cell surface protein
H7F24_RS03920	COG1733	regulation of RNA biosynthetic process
H7F24_RS03925	COG2514	catechol 2,3-dioxygenase activity
H7F24_RS03930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F24_RS03930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F24_RS03935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F24_RS03935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F24_RS03945	COG0726	polysaccharide deacetylase
H7F24_RS03950	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7F24_RS03955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F24_RS03960	COG2723	6-phospho-beta-galactosidase activity
H7F24_RS03965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F24_RS03970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS03970	COG3711	transcriptional antiterminator
H7F24_RS03995	COG1757	Na H antiporter
H7F24_RS04000	COG1027	Aspartate ammonia-lyase
H7F24_RS04005	COG0252	asparaginase activity
H7F24_RS04010	COG1396	sequence-specific DNA binding
H7F24_RS04035	COG4842	Belongs to the WXG100 family
H7F24_RS04040	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7F24_RS04055	COG1737	Transcriptional regulator
H7F24_RS04060	COG2084	Dehydrogenase
H7F24_RS04070	COG2610	gluconate transmembrane transporter activity
H7F24_RS04075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7F24_RS04085	COG2723	6-phospho-beta-galactosidase activity
H7F24_RS04090	COG2190	(PTS) system
H7F24_RS04090	COG1263	PTS System
H7F24_RS04090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS04095	COG3711	transcriptional antiterminator
H7F24_RS04100	COG3878	Protein conserved in bacteria
H7F24_RS04110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H7F24_RS04115	COG1122	ATPase activity
H7F24_RS04120	COG4721	ABC-type cobalt transport system, permease component
H7F24_RS04125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7F24_RS04160	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7F24_RS04165	COG0778	Nitroreductase
H7F24_RS04170	COG1846	Transcriptional regulator
H7F24_RS04175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7F24_RS04180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7F24_RS04185	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7F24_RS04190	COG2390	Transcriptional regulator
H7F24_RS04200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7F24_RS04200	COG2755	lipolytic protein G-D-S-L family
H7F24_RS04220	COG0561	phosphatase activity
H7F24_RS04225	COG0789	Transcriptional regulator
H7F24_RS04230	COG0673	inositol 2-dehydrogenase activity
H7F24_RS04235	COG0840	transmembrane signaling receptor activity
H7F24_RS04240	COG1113	amino acid transport
H7F24_RS04245	COG4335	DNA alkylation repair
H7F24_RS04255	COG1070	Carbohydrate kinase
H7F24_RS04260	COG1737	Transcriptional regulator
H7F24_RS04290	COG0583	DNA-binding transcription factor activity
H7F24_RS04295	COG1609	Transcriptional regulator
H7F24_RS04300	COG2182	Extracellular solute-binding protein
H7F24_RS04305	COG1175	transmembrane transport
H7F24_RS04310	COG3833	ABC-type maltose transport systems, permease component
H7F24_RS04320	COG1874	Beta-galactosidase
H7F24_RS04325	COG2851	Citrate transporter
H7F24_RS04335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H7F24_RS04340	COG1131	(ABC) transporter
H7F24_RS04345	COG2824	Alkylphosphonate utilization operon protein PhnA
H7F24_RS04350	COG1929	Belongs to the glycerate kinase type-1 family
H7F24_RS04355	COG2610	gluconate transmembrane transporter activity
H7F24_RS04360	COG3835	regulator
H7F24_RS04365	COG1309	transcriptional regulator
H7F24_RS04370	COG2814	Major facilitator Superfamily
H7F24_RS04380	COG1136	(ABC) transporter
H7F24_RS04380	COG0577	efflux transmembrane transporter activity
H7F24_RS04390	COG0457	Tetratricopeptide repeat
H7F24_RS04395	COG3711	transcriptional antiterminator
H7F24_RS04400	COG2723	6-phospho-beta-galactosidase activity
H7F24_RS04405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS04405	COG2190	(PTS) system
H7F24_RS04405	COG1263	PTS System
H7F24_RS04440	COG1113	amino acid transport
H7F24_RS04445	COG1609	Transcriptional regulator
H7F24_RS04450	COG2814	Major facilitator Superfamily
H7F24_RS04460	COG2814	Major facilitator Superfamily
H7F24_RS04480	COG5444	nuclease activity
H7F24_RS04490	COG2723	6-phospho-beta-galactosidase activity
H7F24_RS04500	COG2188	Transcriptional regulator
H7F24_RS04510	COG0384	phenazine biosynthesis protein PhzF
H7F24_RS04515	COG0583	DNA-binding transcription factor activity
H7F24_RS04540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7F24_RS04550	COG2814	Major facilitator Superfamily
H7F24_RS04555	COG0640	Transcriptional regulator
H7F24_RS04575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7F24_RS04585	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H7F24_RS04595	COG4720	Psort location CytoplasmicMembrane, score
H7F24_RS04615	COG0456	acetyltransferase
H7F24_RS04620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F24_RS04625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7F24_RS04630	COG4853	Protein conserved in bacteria
H7F24_RS04635	COG4863	YycH protein
H7F24_RS04640	COG5002	protein histidine kinase activity
H7F24_RS04645	COG0745	RESPONSE REGULATOR receiver
H7F24_RS04670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7F24_RS04680	COG2311	Membrane
H7F24_RS04685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7F24_RS04690	COG0346	lactoylglutathione lyase activity
H7F24_RS04695	COG0305	Participates in initiation and elongation during chromosome replication
H7F24_RS04720	COG2819	hydrolase of the alpha beta superfamily
H7F24_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS04730	COG1169	isochorismate synthase
H7F24_RS04735	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7F24_RS04740	COG1535	isochorismatase
H7F24_RS04740	COG3433	isochorismatase activity
H7F24_RS04745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F24_RS04750	COG3251	PFAM MbtH domain protein
H7F24_RS04755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F24_RS04755	COG2207	Transcriptional regulator
H7F24_RS04760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F24_RS04765	COG2819	hydrolase of the alpha beta superfamily
H7F24_RS04770	COG3093	addiction module antidote protein HigA
H7F24_RS04775	COG2807	transmembrane transport
H7F24_RS04780	COG0359	binds to the 23S rRNA
H7F24_RS04785	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H7F24_RS04790	COG4241	membrane
H7F24_RS04795	COG1227	inorganic diphosphatase activity
H7F24_RS04805	COG1595	DNA-templated transcription, initiation
H7F24_RS04815	COG0753	catalase activity
H7F24_RS04820	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7F24_RS04825	COG0400	carboxylic ester hydrolase activity
H7F24_RS04830	COG0346	lactoylglutathione lyase activity
H7F24_RS04835	COG1174	glycine betaine transport
H7F24_RS04840	COG1125	glycine betaine transport
H7F24_RS04840	COG0517	IMP dehydrogenase activity
H7F24_RS04845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7F24_RS04850	COG0629	single-stranded DNA binding
H7F24_RS04855	COG0360	Binds together with S18 to 16S ribosomal RNA
H7F24_RS04860	COG0012	GTP binding
H7F24_RS04865	COG4481	Protein conserved in bacteria
H7F24_RS04880	COG3949	Membrane
H7F24_RS04890	COG1475	DNA binding
H7F24_RS04895	COG1192	Involved in chromosome partitioning
H7F24_RS04905	COG1475	DNA binding
H7F24_RS04910	COG0357	Ribosomal RNA small subunit methyltransferase G
H7F24_RS04915	COG0445	tRNA wobble uridine modification
H7F24_RS04920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7F24_RS04925	COG1847	R3H domain protein
H7F24_RS04930	COG0706	membrane insertase activity
H7F24_RS04935	COG0594	ribonuclease P activity
H7F24_RS04940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7F24_RS04945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7F24_RS04950	COG0592	DNA-directed DNA polymerase activity
H7F24_RS04955	COG2501	S4 domain
H7F24_RS04960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7F24_RS04970	COG0187	DNA topoisomerase II activity
H7F24_RS04975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7F24_RS05010	COG0516	GMP reductase activity
H7F24_RS05010	COG0517	IMP dehydrogenase activity
H7F24_RS05015	COG1686	Belongs to the peptidase S11 family
H7F24_RS05020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F24_RS05025	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H7F24_RS05030	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H7F24_RS05035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7F24_RS05040	COG0840	transmembrane signaling receptor activity
H7F24_RS05050	COG1428	Deoxynucleoside kinase
H7F24_RS05055	COG1428	Deoxynucleoside kinase
H7F24_RS05060	COG3858	chitin binding
H7F24_RS05060	COG1388	LysM domain
H7F24_RS05065	COG1335	isochorismatase
H7F24_RS05070	COG0590	tRNA wobble adenosine to inosine editing
H7F24_RS05080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7F24_RS05085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7F24_RS05090	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7F24_RS05135	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
H7F24_RS05140	COG3853	Toxic anion resistance protein (TelA)
H7F24_RS05145	COG1982	Orn Lys Arg decarboxylase major
H7F24_RS05150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7F24_RS05155	COG3870	Protein conserved in bacteria
H7F24_RS05160	COG1728	Protein conserved in bacteria
H7F24_RS05165	COG0470	DNA polymerase III
H7F24_RS05170	COG1774	PSP1 C-terminal conserved region
H7F24_RS05175	COG4467	Involved in initiation control of chromosome replication
H7F24_RS05180	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7F24_RS05185	COG2827	Endonuclease containing a URI domain
H7F24_RS05190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7F24_RS05195	COG2002	toxin-antitoxin pair type II binding
H7F24_RS05200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F24_RS05200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F24_RS05205	COG0084	hydrolase, TatD family'
H7F24_RS05210	COG3583	domain protein
H7F24_RS05210	COG3584	3D domain protein
H7F24_RS05215	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H7F24_RS05220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7F24_RS05230	COG4466	Protein conserved in bacteria
H7F24_RS05240	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7F24_RS05245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7F24_RS05250	COG0251	oxidation-reduction process
H7F24_RS05255	COG2088	sporulation resulting in formation of a cellular spore
H7F24_RS05265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7F24_RS05270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7F24_RS05275	COG0193	aminoacyl-tRNA hydrolase activity
H7F24_RS05285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7F24_RS05290	COG2002	toxin-antitoxin pair type II binding
H7F24_RS05295	COG2244	polysaccharide biosynthetic process
H7F24_RS05300	COG3956	TIGRFAM MazG family protein
H7F24_RS05305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H7F24_RS05320	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7F24_RS05325	COG1098	S1 RNA binding domain
H7F24_RS05340	COG2208	phosphoserine phosphatase activity
H7F24_RS05345	COG2304	oxidoreductase activity
H7F24_RS05350	COG0515	serine threonine protein kinase
H7F24_RS05355	COG0037	tRNA processing
H7F24_RS05360	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7F24_RS05365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7F24_RS05370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H7F24_RS05375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7F24_RS05380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7F24_RS05385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F24_RS05390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7F24_RS05395	COG0512	Glutamine amidotransferase of anthranilate synthase
H7F24_RS05400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F24_RS05405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7F24_RS05410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7F24_RS05415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7F24_RS05420	COG1396	sequence-specific DNA binding
H7F24_RS05425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7F24_RS05430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7F24_RS05510	COG4463	regulation of RNA biosynthetic process
H7F24_RS05515	COG3880	PFAM UvrB UvrC protein
H7F24_RS05520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
H7F24_RS05525	COG0542	response to heat
H7F24_RS05530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7F24_RS05535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H7F24_RS05540	COG4956	integral membrane protein (PIN domain superfamily)
H7F24_RS05545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7F24_RS05550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7F24_RS05555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7F24_RS05560	COG1045	serine acetyltransferase
H7F24_RS05565	COG0215	cysteine-tRNA ligase activity
H7F24_RS05570	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H7F24_RS05575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7F24_RS05580	COG3688	RNA-binding protein containing a PIN domain
H7F24_RS05585	COG1595	DNA-templated transcription, initiation
H7F24_RS05590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7F24_RS05595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7F24_RS05600	COG0250	Participates in transcription elongation, termination and antitermination
H7F24_RS05610	COG0081	regulation of translation
H7F24_RS05615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7F24_RS05620	COG0222	ribosome binding
H7F24_RS05625	COG2813	Specifically methylates the guanine in position
H7F24_RS05630	COG0085	RNA polymerase activity
H7F24_RS05635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7F24_RS05640	COG1358	cellular component organization or biogenesis
H7F24_RS05645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7F24_RS05650	COG0049	tRNA binding
H7F24_RS05655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7F24_RS05660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7F24_RS05665	COG0596	Alpha beta hydrolase
H7F24_RS05675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7F24_RS05680	COG0088	Forms part of the polypeptide exit tunnel
H7F24_RS05685	COG0089	rRNA binding
H7F24_RS05690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7F24_RS05695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7F24_RS05700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7F24_RS05705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7F24_RS05715	COG0255	Belongs to the universal ribosomal protein uL29 family
H7F24_RS05720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7F24_RS05725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7F24_RS05730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7F24_RS05735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7F24_RS05740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7F24_RS05745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7F24_RS05750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7F24_RS05755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7F24_RS05760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7F24_RS05765	COG1841	ribosomal large subunit assembly
H7F24_RS05770	COG0200	Binds to the 23S rRNA
H7F24_RS05775	COG0201	protein transport
H7F24_RS05780	COG0563	adenylate kinase activity
H7F24_RS05785	COG0024	Methionine aminopeptidase
H7F24_RS05790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7F24_RS05795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7F24_RS05800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7F24_RS05805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7F24_RS05810	COG0202	RNA polymerase activity
H7F24_RS05815	COG0203	ribosomal protein L17
H7F24_RS05820	COG1122	ATPase activity
H7F24_RS05825	COG1122	ATPase activity
H7F24_RS05830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H7F24_RS05835	COG0101	tRNA pseudouridine synthase activity
H7F24_RS05840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7F24_RS05845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7F24_RS05850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F24_RS05875	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS05880	COG0489	protein tyrosine kinase activity
H7F24_RS05890	COG2194	sulfuric ester hydrolase activity
H7F24_RS05895	COG0726	polysaccharide deacetylase
H7F24_RS05925	COG0659	secondary active sulfate transmembrane transporter activity
H7F24_RS05930	COG0385	Bile acid
H7F24_RS05935	COG3876	Protein conserved in bacteria
H7F24_RS05940	COG1472	Belongs to the glycosyl hydrolase 3 family
H7F24_RS05945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7F24_RS05950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS05950	COG1263	PTS System
H7F24_RS05955	COG1737	Transcriptional regulator
H7F24_RS05960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H7F24_RS05995	COG1595	DNA-templated transcription, initiation
H7F24_RS06000	COG5662	AntiSigma factor
H7F24_RS06005	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H7F24_RS06010	COG4856	YbbR-like protein
H7F24_RS06015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7F24_RS06020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7F24_RS06040	COG1131	(ABC) transporter
H7F24_RS06055	COG1131	(ABC) transporter
H7F24_RS06065	COG1413	lyase activity
H7F24_RS06075	COG2311	Membrane
H7F24_RS06095	COG1113	amino acid transport
H7F24_RS06100	COG0584	glycerophosphoryl diester phosphodiesterase
H7F24_RS06105	COG2271	Major facilitator Superfamily
H7F24_RS06115	COG1331	Highly conserved protein containing a thioredoxin domain
H7F24_RS06120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F24_RS06140	COG1937	Protein conserved in bacteria
H7F24_RS06145	COG2210	Belongs to the sulfur carrier protein TusA family
H7F24_RS06155	COG0425	Belongs to the sulfur carrier protein TusA family
H7F24_RS06155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F24_RS06160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F24_RS06160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F24_RS06165	COG0425	Belongs to the sulfur carrier protein TusA family
H7F24_RS06170	COG0730	response to heat
H7F24_RS06180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7F24_RS06185	COG2814	Major facilitator Superfamily
H7F24_RS06195	COG1846	Transcriptional regulator
H7F24_RS06205	COG1683	Conserved Protein
H7F24_RS06215	COG0656	L-ascorbic acid biosynthetic process
H7F24_RS06220	COG1054	Belongs to the UPF0176 family
H7F24_RS06225	COG0531	amino acid
H7F24_RS06235	COG3711	transcriptional antiterminator
H7F24_RS06240	COG1263	PTS System
H7F24_RS06240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS06240	COG2190	(PTS) system
H7F24_RS06245	COG2723	6-phospho-beta-galactosidase activity
H7F24_RS06265	COG3711	transcriptional antiterminator
H7F24_RS06265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS06270	COG1940	carbohydrate kinase activity
H7F24_RS06275	COG0383	alpha-mannosidase activity
H7F24_RS06280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F24_RS06285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F24_RS06295	COG1404	Belongs to the peptidase S8 family
H7F24_RS06310	COG0833	amino acid
H7F24_RS06315	COG2040	homocysteine
H7F24_RS06320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F24_RS06325	COG1695	Transcriptional regulator
H7F24_RS06340	COG2814	Major facilitator Superfamily
H7F24_RS06345	COG0456	acetyltransferase
H7F24_RS06360	COG1404	Belongs to the peptidase S8 family
H7F24_RS06370	COG1309	transcriptional regulator
H7F24_RS06375	COG1917	Cupin 2, conserved barrel domain protein
H7F24_RS06380	COG1063	alcohol dehydrogenase
H7F24_RS06385	COG1846	Transcriptional regulator
H7F24_RS06390	COG0318	PFAM AMP-dependent synthetase and ligase
H7F24_RS06395	COG0531	amino acid
H7F24_RS06405	COG0596	Alpha beta hydrolase
H7F24_RS06410	COG1115	amino acid carrier protein
H7F24_RS06415	COG2066	Belongs to the glutaminase family
H7F24_RS06420	COG4191	Histidine kinase
H7F24_RS06425	COG0784	Response regulator, receiver
H7F24_RS06430	COG1405	negative regulation of cell septum assembly
H7F24_RS06430	COG3012	SEC-C Motif Domain Protein
H7F24_RS06440	COG2197	response regulator
H7F24_RS06445	COG4585	Histidine kinase
H7F24_RS06455	COG0667	Aldo Keto reductase
H7F24_RS06460	COG3290	protein histidine kinase activity
H7F24_RS06465	COG3279	Response regulator of the LytR AlgR family
H7F24_RS06470	COG4555	ABC transporter
H7F24_RS06475	COG1668	transmembrane transport
H7F24_RS06490	COG3773	Cell wall hydrolase
H7F24_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS06505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F24_RS06510	COG2310	stress, protein
H7F24_RS06515	COG2310	stress, protein
H7F24_RS06520	COG2310	stress, protein
H7F24_RS06525	COG0861	Integral membrane protein TerC family
H7F24_RS06555	COG3853	Toxic anion resistance protein (TelA)
H7F24_RS06560	COG0517	IMP dehydrogenase activity
H7F24_RS06560	COG4175	Glycine betaine
H7F24_RS06565	COG4176	ABC-type proline glycine betaine transport system permease component
H7F24_RS06570	COG2113	Glycine betaine
H7F24_RS06585	COG1473	amidohydrolase
H7F24_RS06590	COG1288	antiporter activity
H7F24_RS06595	COG0039	L-malate dehydrogenase activity
H7F24_RS06600	COG1620	l-lactate permease
H7F24_RS06605	COG1609	Transcriptional regulator
H7F24_RS06610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F24_RS06615	COG0561	phosphatase activity
H7F24_RS06620	COG0673	inositol 2-dehydrogenase activity
H7F24_RS06625	COG0738	Major facilitator superfamily
H7F24_RS06630	COG1280	lysine exporter protein (LysE YggA)
H7F24_RS06640	COG3403	YqcI/YcgG family
H7F24_RS06645	COG1113	amino acid transport
H7F24_RS06650	COG3665	Urea carboxylase-associated protein
H7F24_RS06655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7F24_RS06665	COG1012	belongs to the aldehyde dehydrogenase family
H7F24_RS06670	COG0710	3-dehydroquinate dehydratase activity
H7F24_RS06675	COG0028	Belongs to the TPP enzyme family
H7F24_RS06685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7F24_RS06690	COG2271	Major facilitator Superfamily
H7F24_RS06705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7F24_RS06710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7F24_RS06715	COG1609	Transcriptional regulator
H7F24_RS06720	COG0477	Major facilitator Superfamily
H7F24_RS06725	COG2226	methyltransferase
H7F24_RS06730	COG0583	DNA-binding transcription factor activity
H7F24_RS06735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7F24_RS06740	COG3458	cephalosporin-C deacetylase activity
H7F24_RS06750	COG3541	Predicted nucleotidyltransferase
H7F24_RS06755	COG0506	proline dehydrogenase activity
H7F24_RS06760	COG1012	belongs to the aldehyde dehydrogenase family
H7F24_RS06765	COG2508	Transcriptional regulator
H7F24_RS06770	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H7F24_RS06775	COG0765	amino acid transport
H7F24_RS06780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F24_RS06790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7F24_RS06795	COG1522	sequence-specific DNA binding
H7F24_RS06800	COG2746	aminoglycoside 3-N-acetyltransferase activity
H7F24_RS06810	COG3290	protein histidine kinase activity
H7F24_RS06810	COG0840	transmembrane signaling receptor activity
H7F24_RS06815	COG3209	COG3209 Rhs family protein
H7F24_RS06835	COG3842	ATPase activity
H7F24_RS06850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F24_RS06855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F24_RS06860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F24_RS06875	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H7F24_RS06880	COG0697	spore germination
H7F24_RS06885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F24_RS06900	COG2364	Membrane
H7F24_RS06905	COG1126	abc transporter atp-binding protein
H7F24_RS06910	COG0765	amino acid transport
H7F24_RS06915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F24_RS06920	COG0833	amino acid
H7F24_RS06930	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS06935	COG1312	Catalyzes the dehydration of D-mannonate
H7F24_RS06940	COG1802	Transcriptional regulator
H7F24_RS06945	COG0673	inositol 2-dehydrogenase activity
H7F24_RS06955	COG1904	glucuronate isomerase
H7F24_RS06960	COG3104	oligopeptide transport
H7F24_RS06965	COG5434	Belongs to the glycosyl hydrolase 28 family
H7F24_RS06970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F24_RS06975	COG0456	acetyltransferase
H7F24_RS06980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F24_RS06985	COG0765	amino acid transport
H7F24_RS06990	COG1126	abc transporter atp-binding protein
H7F24_RS06995	COG1473	amidohydrolase
H7F24_RS07000	COG2079	MmgE PrpD family protein
H7F24_RS07005	COG0745	RESPONSE REGULATOR receiver
H7F24_RS07010	COG5002	protein histidine kinase activity
H7F24_RS07010	COG3850	Histidine kinase
H7F24_RS07015	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F24_RS07020	COG0527	aspartate kinase activity
H7F24_RS07025	COG2814	Major facilitator Superfamily
H7F24_RS07030	COG1309	transcriptional regulator
H7F24_RS07040	COG0640	Transcriptional regulator
H7F24_RS07045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F24_RS07050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7F24_RS07055	COG0531	amino acid
H7F24_RS07060	COG1012	belongs to the aldehyde dehydrogenase family
H7F24_RS07065	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7F24_RS07070	COG4549	nuclear export factor GLE1
H7F24_RS07075	COG2372	response to copper ion
H7F24_RS07075	COG1276	copper resistance
H7F24_RS07080	COG2213	PTS system mannitol-specific
H7F24_RS07085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS07090	COG0246	Mannitol dehydrogenase
H7F24_RS07095	COG0840	transmembrane signaling receptor activity
H7F24_RS07120	COG0346	lactoylglutathione lyase activity
H7F24_RS07130	COG0561	phosphatase activity
H7F24_RS07135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H7F24_RS07140	COG1914	H( )-stimulated, divalent metal cation uptake system
H7F24_RS07145	COG4336	lyase activity
H7F24_RS07150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H7F24_RS07155	COG1984	allophanate hydrolase subunit 2
H7F24_RS07160	COG1414	Transcriptional regulator
H7F24_RS07165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7F24_RS07170	COG2755	lipolytic protein G-D-S-L family
H7F24_RS07180	COG3711	transcriptional antiterminator
H7F24_RS07185	COG2226	methyltransferase
H7F24_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS07195	COG3871	stress protein (general stress protein 26)
H7F24_RS07220	COG2814	Major facilitator Superfamily
H7F24_RS07225	COG1802	Transcriptional regulator
H7F24_RS07230	COG2207	Transcriptional regulator
H7F24_RS07230	COG1917	Cupin 2, conserved barrel domain protein
H7F24_RS07235	COG0697	spore germination
H7F24_RS07240	COG0473	3-isopropylmalate dehydrogenase activity
H7F24_RS07245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7F24_RS07245	COG0551	DNA topoisomerase type I activity
H7F24_RS07250	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7F24_RS07255	COG3706	GGDEF domain
H7F24_RS07260	COG5298	Protein conserved in bacteria
H7F24_RS07265	COG1215	transferase activity, transferring glycosyl groups
H7F24_RS07275	COG0531	amino acid
H7F24_RS07280	COG0028	Belongs to the TPP enzyme family
H7F24_RS07285	COG5444	nuclease activity
H7F24_RS07310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F24_RS07315	COG1914	H( )-stimulated, divalent metal cation uptake system
H7F24_RS07320	COG2261	transglycosylase associated protein
H7F24_RS07325	COG2217	Heavy metal translocating P-type atpase
H7F24_RS07330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7F24_RS07335	COG3290	protein histidine kinase activity
H7F24_RS07340	COG4565	transcriptional regulatory protein
H7F24_RS07345	COG1301	dicarboxylic acid transport
H7F24_RS07350	COG0628	permease
H7F24_RS07355	COG1301	dicarboxylic acid transport
H7F24_RS07360	COG1131	(ABC) transporter
H7F24_RS07365	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H7F24_RS07380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F24_RS07385	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7F24_RS07390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7F24_RS07405	COG0513	Belongs to the DEAD box helicase family
H7F24_RS07410	COG3402	PFAM membrane-flanked domain
H7F24_RS07415	COG3428	Bacterial PH domain
H7F24_RS07420	COG0705	Rhomboid family
H7F24_RS07425	COG0736	holo-[acyl-carrier-protein] synthase activity
H7F24_RS07430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7F24_RS07435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7F24_RS07440	COG0864	Transcriptional regulator
H7F24_RS07445	COG2337	Toxic component of a toxin-antitoxin (TA) module
H7F24_RS07450	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F24_RS07455	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F24_RS07460	COG2172	sigma factor antagonist activity
H7F24_RS07465	COG2208	phosphoserine phosphatase activity
H7F24_RS07470	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F24_RS07475	COG2172	sigma factor antagonist activity
H7F24_RS07480	COG1191	sigma factor activity
H7F24_RS07485	COG2208	phosphoserine phosphatase activity
H7F24_RS07490	COG2183	response to ionizing radiation
H7F24_RS07500	COG3091	SprT-like family
H7F24_RS07505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F24_RS07510	COG0022	dehydrogenase e1 component
H7F24_RS07515	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F24_RS07520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F24_RS07525	COG3284	Transcriptional regulator
H7F24_RS07565	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7F24_RS07575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F24_RS07580	COG0456	acetyltransferase
H7F24_RS07580	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H7F24_RS07585	COG1278	Cold shock
H7F24_RS07590	COG1404	Belongs to the peptidase S8 family
H7F24_RS07605	COG0789	Transcriptional regulator
H7F24_RS07615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7F24_RS07640	COG0477	Major facilitator Superfamily
H7F24_RS07645	COG0657	acetylesterase activity
H7F24_RS07650	COG4221	oxidoreductase activity
H7F24_RS07660	COG0252	asparaginase activity
H7F24_RS07680	COG2814	Major facilitator Superfamily
H7F24_RS07685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F24_RS07715	COG1309	transcriptional regulator
H7F24_RS07720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7F24_RS07725	COG1846	Transcriptional regulator
H7F24_RS07730	COG0778	Nitroreductase
H7F24_RS07745	COG1396	sequence-specific DNA binding
H7F24_RS07765	COG4122	O-methyltransferase activity
H7F24_RS07775	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H7F24_RS07780	COG0697	spore germination
H7F24_RS07790	COG1301	dicarboxylic acid transport
H7F24_RS07830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7F24_RS07835	COG0802	atpase or kinase
H7F24_RS07840	COG1214	PFAM Peptidase M22, glycoprotease
H7F24_RS07845	COG0456	acetyltransferase
H7F24_RS07850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7F24_RS07855	COG0488	(ABC) transporter
H7F24_RS07860	COG0315	cyclic pyranopterin monophosphate synthase activity
H7F24_RS07865	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H7F24_RS07870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7F24_RS07875	COG0805	protein transport
H7F24_RS07890	COG1266	CAAX protease self-immunity
H7F24_RS07895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7F24_RS07900	COG0459	protein refolding
H7F24_RS07975	COG1846	Transcriptional regulator
H7F24_RS07980	COG0456	acetyltransferase
H7F24_RS07985	COG2808	Putative FMN-binding domain
H7F24_RS08015	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7F24_RS08020	COG0823	Involved in the tonB-independent uptake of proteins
H7F24_RS08030	COG2132	Multicopper oxidase
H7F24_RS08035	COG1113	amino acid transport
H7F24_RS08040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7F24_RS08045	COG0714	Associated with various cellular activities
H7F24_RS08050	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
H7F24_RS08055	COG1305	Transglutaminase-like
H7F24_RS08060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7F24_RS08060	COG0519	Catalyzes the synthesis of GMP from XMP
H7F24_RS08065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7F24_RS08075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7F24_RS08080	COG2207	Transcriptional regulator
H7F24_RS08095	COG1404	Belongs to the peptidase S8 family
H7F24_RS08110	COG2814	Major facilitator Superfamily
H7F24_RS08115	COG0583	DNA-binding transcription factor activity
H7F24_RS08120	COG2252	PERMEase
H7F24_RS08135	COG3064	Membrane
H7F24_RS08140	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H7F24_RS08150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7F24_RS08155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7F24_RS08160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7F24_RS08165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7F24_RS08170	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7F24_RS08175	COG0047	phosphoribosylformylglycinamidine synthase activity
H7F24_RS08180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7F24_RS08185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7F24_RS08190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7F24_RS08195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7F24_RS08200	COG0138	bifunctional purine biosynthesis protein purh
H7F24_RS08205	COG0151	Belongs to the GarS family
H7F24_RS08225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7F24_RS08230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7F24_RS08235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7F24_RS08240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7F24_RS08250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7F24_RS08255	COG4496	protein, YerC YecD
H7F24_RS08260	COG0069	glutamate synthase activity
H7F24_RS08275	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H7F24_RS08280	COG0210	DNA helicase
H7F24_RS08285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7F24_RS08290	COG4851	CamS sex pheromone cAM373 precursor
H7F24_RS08305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7F24_RS08320	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F24_RS08335	COG1960	acyl-CoA dehydrogenase activity
H7F24_RS08365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7F24_RS08370	COG1785	Belongs to the alkaline phosphatase family
H7F24_RS08375	COG1285	pathogenesis
H7F24_RS08380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F24_RS08385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7F24_RS08390	COG0154	amidase activity
H7F24_RS08395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7F24_RS08400	COG1309	transcriptional regulator
H7F24_RS08405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7F24_RS08410	COG1957	nucleoside hydrolase
H7F24_RS08415	COG1597	lipid kinase activity
H7F24_RS08420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7F24_RS08425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7F24_RS08435	COG1737	Transcriptional regulator
H7F24_RS08440	COG1263	PTS System
H7F24_RS08440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS08445	COG1486	melibiose metabolic process
H7F24_RS08455	COG1959	2 iron, 2 sulfur cluster binding
H7F24_RS08460	COG0492	ferredoxin-NADP+ reductase activity
H7F24_RS08475	COG1486	melibiose metabolic process
H7F24_RS08485	COG2211	Major facilitator Superfamily
H7F24_RS08515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7F24_RS08520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F24_RS08525	COG1442	glycosyl transferase family 8
H7F24_RS08530	COG1216	Glycosyl transferase, family 2
H7F24_RS08535	COG1442	glycosyl transferase family 8
H7F24_RS08540	COG2223	nitrite transmembrane transporter activity
H7F24_RS08550	COG0471	metal ion transport
H7F24_RS08565	COG0071	Belongs to the small heat shock protein (HSP20) family
H7F24_RS08580	COG0531	amino acid
H7F24_RS08585	COG0463	Glycosyl transferase, family 2
H7F24_RS08590	COG0488	(ABC) transporter
H7F24_RS08595	COG1469	GTP cyclohydrolase I activity
H7F24_RS08600	COG0789	Transcriptional regulator
H7F24_RS08605	COG2814	Major facilitator Superfamily
H7F24_RS08610	COG0488	(ABC) transporter
H7F24_RS08615	COG0513	Belongs to the DEAD box helicase family
H7F24_RS08630	COG2130	NADP-dependent
H7F24_RS08650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F24_RS08650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F24_RS08655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7F24_RS08665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F24_RS08665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F24_RS08675	COG3290	protein histidine kinase activity
H7F24_RS08680	COG4565	transcriptional regulatory protein
H7F24_RS08685	COG3181	Tripartite tricarboxylate transporter family receptor
H7F24_RS08690	COG2851	Citrate transporter
H7F24_RS08700	COG3479	Phenolic acid decarboxylase
H7F24_RS08705	COG1695	Transcriptional regulator
H7F24_RS08710	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H7F24_RS08715	COG1254	Belongs to the acylphosphatase family
H7F24_RS08720	COG2258	MOSC domain
H7F24_RS08735	COG0024	Methionine aminopeptidase
H7F24_RS08740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS08740	COG1263	PTS System
H7F24_RS08745	COG3739	integral membrane protein
H7F24_RS08760	COG1368	sulfuric ester hydrolase activity
H7F24_RS08765	COG0076	glutamate decarboxylase activity
H7F24_RS08770	COG0840	transmembrane signaling receptor activity
H7F24_RS08780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS08780	COG1263	PTS System
H7F24_RS08785	COG0366	Alpha amylase catalytic
H7F24_RS08790	COG2188	Transcriptional regulator
H7F24_RS08800	COG0737	Belongs to the 5'-nucleotidase family
H7F24_RS08805	COG0693	protein deglycase activity
H7F24_RS08810	COG4840	Belongs to the UPF0435 family
H7F24_RS08815	COG1115	amino acid carrier protein
H7F24_RS08820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7F24_RS08825	COG4980	gas vesicle protein
H7F24_RS08830	COG1295	ribonuclease BN
H7F24_RS08835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F24_RS08840	COG0477	Major facilitator Superfamily
H7F24_RS08850	COG0387	Pfam Sodium calcium exchanger
H7F24_RS08860	COG0217	transcriptional regulatory protein
H7F24_RS08865	COG0668	transmembrane transport
H7F24_RS08870	COG0535	radical SAM domain protein
H7F24_RS08880	COG0726	polysaccharide deacetylase
H7F24_RS08885	COG0598	Magnesium transport protein CorA
H7F24_RS08895	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H7F24_RS08900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7F24_RS08915	COG0789	Transcriptional regulator
H7F24_RS08920	COG2814	Major facilitator Superfamily
H7F24_RS08930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7F24_RS08975	COG2076	Multidrug Resistance protein
H7F24_RS08980	COG2076	Multidrug Resistance protein
H7F24_RS08985	COG1309	transcriptional regulator
H7F24_RS08995	COG4637	Psort location Cytoplasmic, score
H7F24_RS09000	COG2755	lipolytic protein G-D-S-L family
H7F24_RS09005	COG0492	ferredoxin-NADP+ reductase activity
H7F24_RS09010	COG1742	UPF0060 membrane protein
H7F24_RS09025	COG2318	DinB family
H7F24_RS09035	COG1846	Transcriptional regulator
H7F24_RS09040	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7F24_RS09040	COG0392	lysyltransferase activity
H7F24_RS09060	COG0778	Nitroreductase
H7F24_RS09075	COG1090	epimerase
H7F24_RS09080	COG2137	regulation of response to DNA damage stimulus
H7F24_RS09105	COG0463	Glycosyl transferase, family 2
H7F24_RS09110	COG4485	Bacterial membrane protein, YfhO
H7F24_RS09120	COG2140	Oxalate decarboxylase
H7F24_RS09130	COG1191	sigma factor activity
H7F24_RS09140	COG1988	membrane-bound metal-dependent
H7F24_RS09145	COG1194	a g-specific adenine glycosylase
H7F24_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS09170	COG3557	Belongs to the UPF0374 family
H7F24_RS09175	COG1132	(ABC) transporter
H7F24_RS09180	COG0444	Belongs to the ABC transporter superfamily
H7F24_RS09185	COG4608	Belongs to the ABC transporter superfamily
H7F24_RS09190	COG0747	negative chemotaxis
H7F24_RS09195	COG0601	transmembrane transport
H7F24_RS09200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F24_RS09205	COG4129	membrane
H7F24_RS09210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7F24_RS09215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7F24_RS09220	COG0735	belongs to the Fur family
H7F24_RS09370	COG1368	sulfuric ester hydrolase activity
H7F24_RS09375	COG0681	Belongs to the peptidase S26 family
H7F24_RS09380	COG2873	o-acetylhomoserine
H7F24_RS09390	COG1116	anion transmembrane transporter activity
H7F24_RS09395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7F24_RS09400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7F24_RS09415	COG4152	abc transporter atp-binding protein
H7F24_RS09445	COG3382	B3 4 domain protein
H7F24_RS09450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7F24_RS09460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7F24_RS09465	COG2766	serine protein kinase
H7F24_RS09470	COG2718	Belongs to the UPF0229 family
H7F24_RS09475	COG1566	PFAM secretion protein HlyD family protein
H7F24_RS09480	COG2814	Major facilitator Superfamily
H7F24_RS09485	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7F24_RS09495	COG1278	Cold shock
H7F24_RS09500	COG3706	GGDEF domain
H7F24_RS09525	COG5577	PFAM Coat F domain
H7F24_RS09530	COG5002	protein histidine kinase activity
H7F24_RS09535	COG0737	Belongs to the 5'-nucleotidase family
H7F24_RS09535	COG4085	toxin activity
H7F24_RS09535	COG1525	nuclease
H7F24_RS09540	COG3764	Sortase (surface protein transpeptidase)
H7F24_RS09545	COG0564	pseudouridine synthase activity
H7F24_RS09555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7F24_RS09560	COG3153	acetyltransferase
H7F24_RS09560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7F24_RS09575	COG3835	regulator
H7F24_RS09580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7F24_RS09585	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H7F24_RS09590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7F24_RS09595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7F24_RS09600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7F24_RS09605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7F24_RS09610	COG4585	Histidine kinase
H7F24_RS09610	COG2203	Gaf domain
H7F24_RS09615	COG2197	response regulator
H7F24_RS09630	COG0753	catalase activity
H7F24_RS09635	COG1959	2 iron, 2 sulfur cluster binding
H7F24_RS09640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7F24_RS09640	COG1017	nitric oxide dioxygenase activity
H7F24_RS09645	COG2719	SpoVR family
H7F24_RS09650	COG1785	Belongs to the alkaline phosphatase family
H7F24_RS09655	COG1388	LysM domain
H7F24_RS09655	COG0791	NLP P60 protein
H7F24_RS09660	COG0531	amino acid
H7F24_RS09675	COG1595	DNA-templated transcription, initiation
H7F24_RS09680	COG0204	Acyl-transferase
H7F24_RS09685	COG1253	flavin adenine dinucleotide binding
H7F24_RS09690	COG0789	Transcriptional regulator
H7F24_RS09695	COG1253	flavin adenine dinucleotide binding
H7F24_RS09705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7F24_RS09710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7F24_RS09715	COG0584	glycerophosphoryl diester phosphodiesterase
H7F24_RS09725	COG0668	transmembrane transport
H7F24_RS09730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7F24_RS09735	COG0726	polysaccharide deacetylase
H7F24_RS09740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F24_RS09745	COG0589	response to stress
H7F24_RS09750	COG1132	(ABC) transporter
H7F24_RS09755	COG1132	(ABC) transporter
H7F24_RS09765	COG0702	epimerase
H7F24_RS09775	COG3842	ATPase activity
H7F24_RS09780	COG2508	Transcriptional regulator
H7F24_RS09790	COG0189	ligase activity
H7F24_RS09795	COG0189	ligase activity
H7F24_RS09800	COG4399	Belongs to the UPF0754 family
H7F24_RS09805	COG3679	Belongs to the UPF0342 family
H7F24_RS09810	COG0561	phosphatase activity
H7F24_RS09815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7F24_RS09825	COG0475	glutathione-regulated potassium exporter activity
H7F24_RS09830	COG0490	domain, Protein
H7F24_RS09840	COG1024	Enoyl-CoA hydratase
H7F24_RS09850	COG0420	3'-5' exonuclease activity
H7F24_RS09855	COG4717	serine-type aminopeptidase activity
H7F24_RS09860	COG3481	metal-dependent phosphohydrolase, HD sub domain
H7F24_RS09870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7F24_RS09895	COG1846	Transcriptional regulator
H7F24_RS09900	COG4980	gas vesicle protein
H7F24_RS09915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7F24_RS09920	COG0537	adenosine 5'-monophosphoramidase activity
H7F24_RS09925	COG1131	(ABC) transporter
H7F24_RS09930	COG4473	ABC transporter
H7F24_RS09940	COG1473	amidohydrolase
H7F24_RS09950	COG2329	Antibiotic biosynthesis monooxygenase
H7F24_RS09955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F24_RS09960	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7F24_RS09965	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7F24_RS09970	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7F24_RS09975	COG1309	transcriptional regulator
H7F24_RS09980	COG1511	domain protein
H7F24_RS09985	COG1363	Peptidase, m42
H7F24_RS09990	COG1301	dicarboxylic acid transport
H7F24_RS10000	COG1234	tRNA 3'-trailer cleavage
H7F24_RS10005	COG0095	Lipoate-protein ligase
H7F24_RS10010	COG0318	PFAM AMP-dependent synthetase and ligase
H7F24_RS10020	COG0501	Belongs to the peptidase M48B family
H7F24_RS10025	COG1404	Belongs to the peptidase S8 family
H7F24_RS10030	COG0406	alpha-ribazole phosphatase activity
H7F24_RS10035	COG0840	transmembrane signaling receptor activity
H7F24_RS10040	COG0723	plastoquinol--plastocyanin reductase activity
H7F24_RS10040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7F24_RS10045	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS10055	COG4903	ComK protein
H7F24_RS10065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F24_RS10070	COG2814	Major facilitator Superfamily
H7F24_RS10075	COG2732	(Barnase) inhibitor
H7F24_RS10080	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F24_RS10085	COG4605	iron ion homeostasis
H7F24_RS10090	COG4604	ABC transporter, ATP-binding protein
H7F24_RS10095	COG4607	ABC-type enterochelin transport system periplasmic component
H7F24_RS10100	COG1316	TRANSCRIPTIONal
H7F24_RS10110	COG0398	Pfam SNARE associated Golgi protein
H7F24_RS10115	COG0681	Belongs to the peptidase S26 family
H7F24_RS10120	COG3180	Ammonia monooxygenase
H7F24_RS10130	COG0501	Belongs to the peptidase M48B family
H7F24_RS10135	COG2259	Doxx family
H7F24_RS10140	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H7F24_RS10145	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H7F24_RS10150	COG1074	ATP-dependent DNA helicase activity
H7F24_RS10155	COG0420	3'-5' exonuclease activity
H7F24_RS10160	COG0419	ATPase involved in DNA repair
H7F24_RS10165	COG1403	HNH endonuclease
H7F24_RS10205	COG5337	Spore coat protein CotH
H7F24_RS10215	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7F24_RS10230	COG0367	asparagine synthase
H7F24_RS10245	COG1562	ergosterol biosynthetic process
H7F24_RS10250	COG0534	Mate efflux family protein
H7F24_RS10255	COG1917	Cupin 2, conserved barrel domain protein
H7F24_RS10255	COG2207	Transcriptional regulator
H7F24_RS10285	COG0076	glutamate decarboxylase activity
H7F24_RS10315	COG0646	methionine synthase
H7F24_RS10315	COG1410	methionine synthase
H7F24_RS10320	COG0646	methionine synthase
H7F24_RS10320	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7F24_RS10325	COG1666	GTP binding
H7F24_RS10330	COG2996	Protein conserved in bacteria
H7F24_RS10335	COG1744	ABC transporter substrate-binding protein PnrA-like
H7F24_RS10340	COG0840	transmembrane signaling receptor activity
H7F24_RS10345	COG1307	EDD domain protein, DegV family
H7F24_RS10350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F24_RS10370	COG0561	phosphatase activity
H7F24_RS10375	COG1073	alpha beta
H7F24_RS10380	COG2151	metal-sulfur cluster biosynthetic enzyme
H7F24_RS10385	COG0277	FAD linked oxidase domain protein
H7F24_RS10390	COG2271	Major facilitator Superfamily
H7F24_RS10395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7F24_RS10400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H7F24_RS10405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7F24_RS10410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7F24_RS10415	COG0505	Belongs to the CarA family
H7F24_RS10420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7F24_RS10425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7F24_RS10435	COG2814	Major facilitator Superfamily
H7F24_RS10445	COG2267	carboxylic ester hydrolase activity
H7F24_RS10455	COG1744	ABC transporter substrate-binding protein PnrA-like
H7F24_RS10470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F24_RS10475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F24_RS10480	COG5504	Zn-dependent protease
H7F24_RS10485	COG0444	Belongs to the ABC transporter superfamily
H7F24_RS10490	COG4608	Belongs to the ABC transporter superfamily
H7F24_RS10500	COG0601	transmembrane transport
H7F24_RS10505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F24_RS10525	COG0180	Tryptophanyl-tRNA synthetase
H7F24_RS10535	COG4166	transmembrane transport
H7F24_RS10540	COG0601	transmembrane transport
H7F24_RS10545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F24_RS10550	COG0444	Belongs to the ABC transporter superfamily
H7F24_RS10555	COG4608	Belongs to the ABC transporter superfamily
H7F24_RS10565	COG0456	acetyltransferase
H7F24_RS10570	COG1393	Belongs to the ArsC family
H7F24_RS10575	COG0861	Integral membrane protein TerC family
H7F24_RS10580	COG4862	establishment of competence for transformation
H7F24_RS10585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F24_RS10595	COG1164	Oligoendopeptidase f
H7F24_RS10605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7F24_RS10610	COG2346	COG2346, Truncated hemoglobins
H7F24_RS10615	COG0741	lytic transglycosylase activity
H7F24_RS10620	COG4116	CYTH
H7F24_RS10630	COG2357	RelA SpoT domain protein
H7F24_RS10635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7F24_RS10640	COG0564	pseudouridine synthase activity
H7F24_RS10645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7F24_RS10650	COG0569	domain protein
H7F24_RS10650	COG0475	glutathione-regulated potassium exporter activity
H7F24_RS10655	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7F24_RS10660	COG0352	thiamine-phosphate diphosphorylase activity
H7F24_RS10670	COG2104	thiamine diphosphate biosynthetic process
H7F24_RS10675	COG2022	thiamine diphosphate biosynthetic process
H7F24_RS10680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7F24_RS10685	COG0351	phosphomethylpyrimidine kinase
H7F24_RS10690	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7F24_RS10745	COG0210	DNA helicase
H7F24_RS10760	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H7F24_RS10765	COG2382	esterase
H7F24_RS10770	COG0626	cystathionine gamma-synthase activity
H7F24_RS10775	COG0626	cystathionine gamma-synthase activity
H7F24_RS10925	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7F24_RS10955	COG1780	Probably involved in ribonucleotide reductase function
H7F24_RS10960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F24_RS10970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F24_RS10990	COG0756	dUTP diphosphatase activity
H7F24_RS11000	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H7F24_RS11085	COG0582	viral genome integration into host DNA
H7F24_RS11160	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7F24_RS11195	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS11195	COG3409	Peptidoglycan-binding domain 1 protein
H7F24_RS11230	COG0457	Tetratricopeptide repeat
H7F24_RS11235	COG1733	regulation of RNA biosynthetic process
H7F24_RS11245	COG0604	alcohol dehydrogenase
H7F24_RS11255	COG0825	malonyl-CoA metabolic process
H7F24_RS11265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F24_RS11315	COG0457	Tetratricopeptide repeat
H7F24_RS11345	COG0583	DNA-binding transcription factor activity
H7F24_RS11350	COG2807	transmembrane transport
H7F24_RS11370	COG0457	Tetratricopeptide repeat
H7F24_RS11400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7F24_RS11420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F24_RS11425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F24_RS11430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F24_RS11450	COG4195	phage-related replication protein
H7F24_RS11455	COG2856	Zn peptidase
H7F24_RS11460	COG3409	Peptidoglycan-binding domain 1 protein
H7F24_RS11460	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS11480	COG0306	phosphate transporter
H7F24_RS11485	COG1392	Phosphate transport regulator
H7F24_RS11495	COG0405	Gamma-glutamyltransferase
H7F24_RS11500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7F24_RS11510	COG4208	sulfate ABC transporter
H7F24_RS11515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7F24_RS11525	COG3775	system Galactitol-specific IIC component
H7F24_RS11540	COG1063	alcohol dehydrogenase
H7F24_RS11545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F24_RS11550	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F24_RS11550	COG0022	dehydrogenase e1 component
H7F24_RS11555	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F24_RS11560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F24_RS11565	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS11570	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS11575	COG2390	Transcriptional regulator
H7F24_RS11585	COG0531	amino acid
H7F24_RS11590	COG0346	lactoylglutathione lyase activity
H7F24_RS11595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F24_RS11600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F24_RS11605	COG2362	D-Aminopeptidase
H7F24_RS11610	COG0601	transmembrane transport
H7F24_RS11615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F24_RS11620	COG0444	Belongs to the ABC transporter superfamily
H7F24_RS11625	COG4166	transmembrane transport
H7F24_RS11630	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7F24_RS11635	COG4948	Mandelate Racemase Muconate Lactonizing
H7F24_RS11640	COG0791	NLP P60 protein
H7F24_RS11645	COG4608	Belongs to the ABC transporter superfamily
H7F24_RS11650	COG1834	amidinotransferase
H7F24_RS11655	COG1607	acyl-coa hydrolase
H7F24_RS11660	COG1695	Transcriptional regulator
H7F24_RS11675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F24_RS11690	COG2076	Multidrug Resistance protein
H7F24_RS11695	COG2076	Multidrug Resistance protein
H7F24_RS11705	COG0788	formyltetrahydrofolate deformylase activity
H7F24_RS11710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7F24_RS11715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7F24_RS11720	COG0457	Tetratricopeptide repeat
H7F24_RS11730	COG1764	response to oxidative stress
H7F24_RS11735	COG1846	Transcriptional regulator
H7F24_RS11740	COG1764	response to oxidative stress
H7F24_RS11745	COG0590	tRNA wobble adenosine to inosine editing
H7F24_RS11750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7F24_RS11755	COG1404	Belongs to the peptidase S8 family
H7F24_RS11760	COG0745	RESPONSE REGULATOR receiver
H7F24_RS11765	COG3850	Histidine kinase
H7F24_RS11765	COG5002	protein histidine kinase activity
H7F24_RS11770	COG3212	peptidase
H7F24_RS11775	COG3212	peptidase
H7F24_RS11785	COG2239	Acts as a magnesium transporter
H7F24_RS11795	COG0789	Transcriptional regulator
H7F24_RS11815	COG1846	Transcriptional regulator
H7F24_RS11820	COG3300	MHYT domain
H7F24_RS11820	COG5001	Diguanylate cyclase
H7F24_RS11825	COG0586	Pfam SNARE associated Golgi protein
H7F24_RS11830	COG0861	Integral membrane protein TerC family
H7F24_RS11835	COG1191	sigma factor activity
H7F24_RS11855	COG0501	Belongs to the peptidase M48B family
H7F24_RS11860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7F24_RS11865	COG2323	membrane
H7F24_RS11880	COG3594	Acyltransferase
H7F24_RS11885	COG5002	protein histidine kinase activity
H7F24_RS11890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7F24_RS11900	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7F24_RS11905	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H7F24_RS11910	COG0436	Aminotransferase
H7F24_RS11915	COG1850	ribulose-bisphosphate carboxylase activity
H7F24_RS11925	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H7F24_RS11935	COG3852	Histidine kinase
H7F24_RS11940	COG1846	Transcriptional regulator
H7F24_RS11945	COG1360	Flagellar Motor Protein
H7F24_RS11950	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7F24_RS11955	COG0542	response to heat
H7F24_RS11960	COG3949	Membrane
H7F24_RS11965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7F24_RS11970	COG0720	synthase
H7F24_RS11975	COG0602	queuosine metabolic process
H7F24_RS11980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7F24_RS11985	COG1733	regulation of RNA biosynthetic process
H7F24_RS11990	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS12000	COG4873	Protein conserved in bacteria
H7F24_RS12010	COG3773	Cell wall hydrolase
H7F24_RS12015	COG2244	polysaccharide biosynthetic process
H7F24_RS12020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F24_RS12025	COG2217	Heavy metal translocating P-type atpase
H7F24_RS12030	COG0006	proline dipeptidase activity
H7F24_RS12040	COG1609	Transcriptional regulator
H7F24_RS12045	COG3711	transcriptional antiterminator
H7F24_RS12050	COG2190	(PTS) system
H7F24_RS12050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS12050	COG1263	PTS System
H7F24_RS12055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS12060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7F24_RS12070	COG1533	DNA photolyase activity
H7F24_RS12075	COG0840	transmembrane signaling receptor activity
H7F24_RS12085	COG2084	Dehydrogenase
H7F24_RS12090	COG2340	Cysteine-rich secretory protein family
H7F24_RS12095	COG0768	penicillin binding
H7F24_RS12100	COG4191	Histidine kinase
H7F24_RS12105	COG0436	Aminotransferase
H7F24_RS12110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7F24_RS12120	COG1714	RDD family
H7F24_RS12130	COG0835	chemotaxis
H7F24_RS12130	COG0784	Response regulator, receiver
H7F24_RS12140	COG1917	Cupin 2, conserved barrel domain protein
H7F24_RS12140	COG2207	Transcriptional regulator
H7F24_RS12145	COG0697	spore germination
H7F24_RS12155	COG2814	Major facilitator Superfamily
H7F24_RS12160	COG1376	ErfK ybiS ycfS ynhG family protein
H7F24_RS12165	COG1408	metallophosphoesterase
H7F24_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS12175	COG2200	EAL domain
H7F24_RS12180	COG3546	catalase activity
H7F24_RS12185	COG4703	Protein of unknown function (DUF1797)
H7F24_RS12190	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H7F24_RS12200	COG0517	IMP dehydrogenase activity
H7F24_RS12205	COG0583	DNA-binding transcription factor activity
H7F24_RS12210	COG0716	FMN binding
H7F24_RS12220	COG0716	FMN binding
H7F24_RS12225	COG2171	N-acyltransferase activity
H7F24_RS12230	COG1473	amidohydrolase
H7F24_RS12240	COG0668	transmembrane transport
H7F24_RS12245	COG0450	alkyl hydroperoxide reductase
H7F24_RS12250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F24_RS12265	COG0746	molybdenum cofactor guanylyltransferase activity
H7F24_RS12270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7F24_RS12275	COG0303	'Molybdopterin
H7F24_RS12280	COG1763	Mo-molybdopterin cofactor biosynthetic process
H7F24_RS12285	COG0314	molybdopterin synthase activity
H7F24_RS12290	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7F24_RS12305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F24_RS12310	COG1136	(ABC) transporter
H7F24_RS12315	COG0577	efflux transmembrane transporter activity
H7F24_RS12320	COG1349	DNA-binding transcription factor activity
H7F24_RS12325	COG1105	Belongs to the carbohydrate kinase PfkB family
H7F24_RS12330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F24_RS12330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F24_RS12330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS12335	COG0681	Belongs to the peptidase S26 family
H7F24_RS12345	COG0488	(ABC) transporter
H7F24_RS12350	COG2309	aminopeptidase activity
H7F24_RS12360	COG1077	Cell shape determining protein MreB Mrl
H7F24_RS12365	COG2002	toxin-antitoxin pair type II binding
H7F24_RS12370	COG3852	Histidine kinase
H7F24_RS12375	COG2105	PFAM AIG2 family protein
H7F24_RS12375	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H7F24_RS12380	COG0569	domain protein
H7F24_RS12385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7F24_RS12390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H7F24_RS12395	COG5503	Protein of unknown function (DUF1447)
H7F24_RS12400	COG0561	phosphatase activity
H7F24_RS12405	COG0242	peptide deformylase activity
H7F24_RS12420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F24_RS12425	COG0022	dehydrogenase e1 component
H7F24_RS12430	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F24_RS12435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F24_RS12440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F24_RS12450	COG1982	Orn Lys Arg decarboxylase major
H7F24_RS12455	COG4476	Belongs to the UPF0223 family
H7F24_RS12460	COG4493	Belongs to the UPF0637 family
H7F24_RS12470	COG0483	inositol monophosphate 1-phosphatase activity
H7F24_RS12485	COG1595	DNA-templated transcription, initiation
H7F24_RS12505	COG1217	gtp-binding protein TYPA
H7F24_RS12515	COG4896	Protein conserved in bacteria
H7F24_RS12525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7F24_RS12530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7F24_RS12535	COG2066	Belongs to the glutaminase family
H7F24_RS12540	COG4838	Belongs to the UPF0358 family
H7F24_RS12545	COG0772	Belongs to the SEDS family
H7F24_RS12550	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H7F24_RS12555	COG0415	Belongs to the DNA photolyase family
H7F24_RS12560	COG1612	heme a metabolic process
H7F24_RS12565	COG0109	protoheme IX farnesyltransferase activity
H7F24_RS12570	COG2010	Cytochrome c
H7F24_RS12570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7F24_RS12575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7F24_RS12580	COG1845	cytochrome c oxidase, subunit III
H7F24_RS12585	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7F24_RS12590	COG3336	cytochrome c oxidase
H7F24_RS12600	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H7F24_RS12605	COG2340	Cysteine-rich secretory protein family
H7F24_RS12625	COG3679	Belongs to the UPF0342 family
H7F24_RS12630	COG4471	UPF0298 protein
H7F24_RS12635	COG0742	ribosomal rna small subunit methyltransferase
H7F24_RS12640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7F24_RS12645	COG3314	Sporulation integral membrane protein YlbJ
H7F24_RS12650	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7F24_RS12655	COG3480	Lon protease (S16) C-terminal proteolytic domain
H7F24_RS12665	COG1399	metal-binding, possibly nucleic acid-binding protein
H7F24_RS12670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7F24_RS12680	COG0454	-acetyltransferase
H7F24_RS12685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7F24_RS12690	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H7F24_RS12695	COG2001	Belongs to the MraZ family
H7F24_RS12700	COG0275	rRNA processing
H7F24_RS12705	COG4839	cell division protein FtsL
H7F24_RS12710	COG0768	penicillin binding
H7F24_RS12715	COG0768	penicillin binding
H7F24_RS12720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7F24_RS12725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7F24_RS12730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7F24_RS12735	COG0772	Belongs to the SEDS family
H7F24_RS12740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7F24_RS12745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7F24_RS12750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7F24_RS12755	COG3879	Bacterial protein of unknown function (DUF881)
H7F24_RS12760	COG3879	Bacterial protein of unknown function (DUF881)
H7F24_RS12765	COG3856	small basic protein
H7F24_RS12770	COG0849	cell division
H7F24_RS12775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7F24_RS12780	COG4412	M6 family metalloprotease domain protein
H7F24_RS12780	COG1404	Belongs to the peptidase S8 family
H7F24_RS12790	COG1191	sigma factor activity
H7F24_RS12795	COG1191	sigma factor activity
H7F24_RS12800	COG2390	Transcriptional regulator
H7F24_RS12815	COG3730	PTS system glucitol sorbitol-specific
H7F24_RS12820	COG3732	PTS system glucitol sorbitol-specific
H7F24_RS12830	COG1119	ATPase activity
H7F24_RS12835	COG1873	PFAM PRC-barrel domain
H7F24_RS12840	COG1496	oxidoreductase activity
H7F24_RS12845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7F24_RS12850	COG1799	cell septum assembly
H7F24_RS12855	COG0762	integral membrane protein
H7F24_RS12860	COG2302	S4 RNA-binding domain
H7F24_RS12865	COG3599	regulation of cell shape
H7F24_RS12870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7F24_RS12875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7F24_RS12880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7F24_RS12885	COG0564	pseudouridine synthase activity
H7F24_RS12890	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H7F24_RS12895	COG2233	PERMEase
H7F24_RS12900	COG0540	Belongs to the ATCase OTCase family
H7F24_RS12910	COG0505	Belongs to the CarA family
H7F24_RS12915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7F24_RS12920	COG0543	2 iron, 2 sulfur cluster binding
H7F24_RS12925	COG0167	dihydroorotate dehydrogenase activity
H7F24_RS12930	COG0284	orotidine-5'-phosphate decarboxylase activity
H7F24_RS12935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7F24_RS12945	COG0175	sulfate reduction
H7F24_RS12950	COG0306	phosphate transporter
H7F24_RS12955	COG2046	Belongs to the sulfate adenylyltransferase family
H7F24_RS12960	COG0529	Catalyzes the synthesis of activated sulfate
H7F24_RS12965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7F24_RS12970	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H7F24_RS12975	COG1648	precorrin-2 dehydrogenase activity
H7F24_RS12985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7F24_RS12990	COG1561	YicC-like family, N-terminal region
H7F24_RS12995	COG2052	Domain of unknown function (DUF370)
H7F24_RS13000	COG0194	GDP metabolic process
H7F24_RS13005	COG1758	RNA polymerase activity
H7F24_RS13010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7F24_RS13015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7F24_RS13020	COG0242	peptide deformylase activity
H7F24_RS13025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7F24_RS13030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7F24_RS13030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7F24_RS13035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7F24_RS13040	COG0631	protein serine/threonine phosphatase activity
H7F24_RS13045	COG0515	serine threonine protein kinase
H7F24_RS13045	COG2815	serine threonine protein kinase
H7F24_RS13050	COG1162	GTPase activity
H7F24_RS13055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7F24_RS13060	COG1564	THIamine pyrophosphokinase
H7F24_RS13070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7F24_RS13075	COG1302	Protein conserved in bacteria
H7F24_RS13080	COG1461	Dihydroxyacetone kinase
H7F24_RS13085	COG1760	l-serine dehydratase
H7F24_RS13090	COG1760	l-serine dehydratase
H7F24_RS13095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7F24_RS13100	COG1349	DNA-binding transcription factor activity
H7F24_RS13105	COG0416	fatty acid biosynthetic process
H7F24_RS13110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7F24_RS13115	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS13120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F24_RS13130	COG1196	nuclear chromosome segregation
H7F24_RS13135	COG0552	protein localization to endoplasmic reticulum
H7F24_RS13140	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H7F24_RS13145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7F24_RS13150	COG0228	four-way junction DNA binding
H7F24_RS13155	COG1837	Belongs to the UPF0109 family
H7F24_RS13165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7F24_RS13170	COG0336	Belongs to the RNA methyltransferase TrmD family
H7F24_RS13175	COG0335	large ribosomal subunit rRNA binding
H7F24_RS13180	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7F24_RS13185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7F24_RS13195	COG2257	FlhB HrpN YscU SpaS Family
H7F24_RS13200	COG0045	succinate-CoA ligase (ADP-forming) activity
H7F24_RS13205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7F24_RS13210	COG0758	DNA mediated transformation
H7F24_RS13215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7F24_RS13220	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H7F24_RS13225	COG4974	Belongs to the 'phage' integrase family
H7F24_RS13230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7F24_RS13235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7F24_RS13240	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H7F24_RS13245	COG1815	bacterial-type flagellum-dependent cell motility
H7F24_RS13250	COG1558	bacterial-type flagellum-dependent cell motility
H7F24_RS13255	COG1677	Flagellar hook-basal body complex protein FliE
H7F24_RS13260	COG1766	The M ring may be actively involved in energy transduction
H7F24_RS13265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7F24_RS13270	COG1317	bacterial-type flagellum organization
H7F24_RS13275	COG1157	protein secretion by the type III secretion system
H7F24_RS13280	COG2882	bacterial-type flagellum organization
H7F24_RS13285	COG3334	PFAM MgtE intracellular
H7F24_RS13290	COG3144	bacterial-type flagellum assembly
H7F24_RS13295	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7F24_RS13300	COG4786	Flagellar basal body rod
H7F24_RS13305	COG1582	Flagellar protein (FlbD)
H7F24_RS13310	COG1580	Controls the rotational direction of flagella during chemotaxis
H7F24_RS13315	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7F24_RS13320	COG1776	CheC inhibitor of MCP methylation
H7F24_RS13320	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7F24_RS13325	COG2201	protein-glutamate methylesterase activity
H7F24_RS13330	COG3190	flagellar
H7F24_RS13335	COG1338	Plays a role in the flagellum-specific transport system
H7F24_RS13340	COG1987	bacterial-type flagellum assembly
H7F24_RS13345	COG1684	flagellar biosynthetic protein fliR
H7F24_RS13350	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7F24_RS13355	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7F24_RS13360	COG1419	protein localization to endoplasmic reticulum
H7F24_RS13365	COG0455	bacterial-type flagellum organization
H7F24_RS13370	COG2201	protein-glutamate methylesterase activity
H7F24_RS13375	COG2198	Histidine kinase
H7F24_RS13375	COG0643	Histidine kinase
H7F24_RS13380	COG0835	chemotaxis
H7F24_RS13385	COG1776	CheC inhibitor of MCP methylation
H7F24_RS13395	COG1191	sigma factor activity
H7F24_RS13410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7F24_RS13415	COG0528	UMP kinase activity
H7F24_RS13420	COG0233	cytoplasmic translational termination
H7F24_RS13425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7F24_RS13430	COG4589	Belongs to the CDS family
H7F24_RS13435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7F24_RS13440	COG0750	zinc metalloprotease
H7F24_RS13445	COG0442	prolyl-tRNA aminoacylation
H7F24_RS13450	COG2176	DNA-directed DNA polymerase activity
H7F24_RS13465	COG3693	PFAM glycoside hydrolase, family 10
H7F24_RS13475	COG0779	Required for maturation of 30S ribosomal subunits
H7F24_RS13480	COG0195	Participates in both transcription termination and antitermination
H7F24_RS13485	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H7F24_RS13490	COG1358	cellular component organization or biogenesis
H7F24_RS13495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7F24_RS13500	COG1550	Protein conserved in bacteria
H7F24_RS13505	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7F24_RS13510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7F24_RS13515	COG0196	riboflavin kinase activity
H7F24_RS13520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7F24_RS13525	COG1185	polyribonucleotide nucleotidyltransferase activity
H7F24_RS13530	COG0726	polysaccharide deacetylase
H7F24_RS13535	COG0612	Peptidase, M16
H7F24_RS13545	COG1873	PFAM PRC-barrel domain
H7F24_RS13550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F24_RS13555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7F24_RS13560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7F24_RS13565	COG0527	aspartate kinase activity
H7F24_RS13575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H7F24_RS13580	COG0740	serine-type endopeptidase activity
H7F24_RS13590	COG1674	ftsk spoiiie
H7F24_RS13590	COG4980	gas vesicle protein
H7F24_RS13595	COG2188	Transcriptional regulator
H7F24_RS13600	COG2814	Major facilitator Superfamily
H7F24_RS13605	COG2409	Drug exporters of the RND superfamily
H7F24_RS13605	COG1033	growth of symbiont in host cell
H7F24_RS13610	COG0612	Peptidase, M16
H7F24_RS13615	COG0612	Peptidase, M16
H7F24_RS13625	COG2409	Drug exporters of the RND superfamily
H7F24_RS13625	COG1033	growth of symbiont in host cell
H7F24_RS13630	COG0300	oxidoreductase activity
H7F24_RS13645	COG1426	Protein conserved in bacteria
H7F24_RS13650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7F24_RS13655	COG1058	Belongs to the CinA family
H7F24_RS13655	COG1546	Belongs to the CinA family
H7F24_RS13660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7F24_RS13665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7F24_RS13670	COG1418	mRNA catabolic process
H7F24_RS13675	COG1692	metallophosphoesterase
H7F24_RS13680	COG2359	stage V sporulation protein S
H7F24_RS13685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7F24_RS13690	COG1063	alcohol dehydrogenase
H7F24_RS13695	COG0156	8-amino-7-oxononanoate synthase activity
H7F24_RS13705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7F24_RS13710	COG4550	Control of competence regulator ComK, YlbF/YmcA
H7F24_RS13720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7F24_RS13725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7F24_RS13745	COG1329	Transcriptional regulator
H7F24_RS13750	COG4195	phage-related replication protein
H7F24_RS13755	COG0457	Tetratricopeptide repeat
H7F24_RS13760	COG1404	Belongs to the peptidase S8 family
H7F24_RS13765	COG4195	phage-related replication protein
H7F24_RS13770	COG1764	response to oxidative stress
H7F24_RS13775	COG2076	Multidrug Resistance protein
H7F24_RS13800	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7F24_RS13805	COG1923	regulation of RNA biosynthetic process
H7F24_RS13820	COG1780	Probably involved in ribonucleotide reductase function
H7F24_RS13825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F24_RS13830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F24_RS13835	COG4112	unkown
H7F24_RS13840	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS13845	COG0464	growth
H7F24_RS13850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7F24_RS13855	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H7F24_RS13860	COG0789	Transcriptional regulator
H7F24_RS13865	COG0174	glutamine synthetase
H7F24_RS13875	COG4282	regulation of fungal-type cell wall biogenesis
H7F24_RS13900	COG0457	Tetratricopeptide repeat
H7F24_RS13905	COG5444	nuclease activity
H7F24_RS13925	COG5646	InterPro IPR014922
H7F24_RS13930	COG0457	Tetratricopeptide repeat
H7F24_RS13935	COG3619	membrane
H7F24_RS13940	COG3285	dna ligase
H7F24_RS13940	COG1793	dna ligase
H7F24_RS13945	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7F24_RS13950	COG4876	unkown
H7F24_RS13955	COG0346	lactoylglutathione lyase activity
H7F24_RS13960	COG1959	2 iron, 2 sulfur cluster binding
H7F24_RS13965	COG0702	epimerase
H7F24_RS13985	COG2323	membrane
H7F24_RS13990	COG1309	transcriptional regulator
H7F24_RS13995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7F24_RS13995	COG2124	cytochrome p450
H7F24_RS14000	COG3591	Belongs to the peptidase S1B family
H7F24_RS14005	COG3209	COG3209 Rhs family protein
H7F24_RS14010	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F24_RS14025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7F24_RS14030	COG1388	LysM domain
H7F24_RS14035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7F24_RS14040	COG4224	UPF0291 protein
H7F24_RS14045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7F24_RS14055	COG3763	UPF0154 protein
H7F24_RS14065	COG0785	Cytochrome C biogenesis protein
H7F24_RS14070	COG4846	Membrane protein involved in cytochrome C biogenesis
H7F24_RS14080	COG0071	Belongs to the small heat shock protein (HSP20) family
H7F24_RS14095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H7F24_RS14100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F24_RS14120	COG0824	Thioesterase
H7F24_RS14130	COG4841	protein insertion into membrane
H7F24_RS14135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7F24_RS14140	COG1832	CoA-binding protein
H7F24_RS14145	COG0187	DNA topoisomerase II activity
H7F24_RS14150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7F24_RS14160	COG0738	Major facilitator superfamily
H7F24_RS14165	COG0110	maltose O-acetyltransferase activity
H7F24_RS14170	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7F24_RS14175	COG1733	regulation of RNA biosynthetic process
H7F24_RS14185	COG1139	Iron-sulfur cluster binding protein
H7F24_RS14190	COG0247	lactate metabolic process
H7F24_RS14205	COG2205	protein histidine kinase activity
H7F24_RS14205	COG3292	Two component regulator propeller
H7F24_RS14205	COG0745	RESPONSE REGULATOR receiver
H7F24_RS14210	COG2197	response regulator
H7F24_RS14215	COG4585	Histidine kinase
H7F24_RS14220	COG2409	Drug exporters of the RND superfamily
H7F24_RS14225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F24_RS14230	COG0251	oxidation-reduction process
H7F24_RS14270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7F24_RS14285	COG0583	DNA-binding transcription factor activity
H7F24_RS14305	COG0657	acetylesterase activity
H7F24_RS14310	COG0789	Transcriptional regulator
H7F24_RS14315	COG2723	6-phospho-beta-galactosidase activity
H7F24_RS14320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F24_RS14320	COG1263	PTS System
H7F24_RS14320	COG2190	(PTS) system
H7F24_RS14335	COG2205	protein histidine kinase activity
H7F24_RS14340	COG0745	RESPONSE REGULATOR receiver
H7F24_RS14350	COG3507	Belongs to the glycosyl hydrolase 43 family
H7F24_RS14355	COG1012	belongs to the aldehyde dehydrogenase family
H7F24_RS14360	COG1486	melibiose metabolic process
H7F24_RS14365	COG0395	ABC-type sugar transport system, permease component
H7F24_RS14370	COG1175	transmembrane transport
H7F24_RS14375	COG1653	transport
H7F24_RS14380	COG1609	Transcriptional regulator
H7F24_RS14385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7F24_RS14400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS14430	COG5444	nuclease activity
H7F24_RS14435	COG1846	Transcriptional regulator
H7F24_RS14440	COG2814	Major facilitator Superfamily
H7F24_RS14450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F24_RS14450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F24_RS14450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS14455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F24_RS14455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F24_RS14455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F24_RS14460	COG1105	Belongs to the carbohydrate kinase PfkB family
H7F24_RS14470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F24_RS14500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7F24_RS14505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F24_RS14510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7F24_RS14515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7F24_RS14520	COG1024	Enoyl-CoA hydratase
H7F24_RS14525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7F24_RS14530	COG0511	ligase activity, forming carbon-carbon bonds
H7F24_RS14535	COG0439	Biotin carboxylase
H7F24_RS14540	COG0318	PFAM AMP-dependent synthetase and ligase
H7F24_RS14545	COG1960	acyl-CoA dehydrogenase activity
H7F24_RS14550	COG1649	PFAM Uncharacterised BCR, COG1649
H7F24_RS14555	COG2365	Tyrosine phosphatase family
H7F24_RS14560	COG1349	DNA-binding transcription factor activity
H7F24_RS14570	COG3835	regulator
H7F24_RS14575	COG0277	FAD linked oxidase domain protein
H7F24_RS14580	COG0247	lactate metabolic process
H7F24_RS14605	COG0166	Belongs to the GPI family
H7F24_RS14610	COG2246	polysaccharide biosynthetic process
H7F24_RS14615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7F24_RS14620	COG0586	Pfam SNARE associated Golgi protein
H7F24_RS14625	COG1587	Uroporphyrinogen-III synthase
H7F24_RS14635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F24_RS14650	COG0534	Mate efflux family protein
H7F24_RS14655	COG2027	D-alanyl-D-alanine carboxypeptidase
H7F24_RS14660	COG4677	pectinesterase activity
H7F24_RS14665	COG2323	membrane
H7F24_RS14670	COG2146	nitrite reductase [NAD(P)H] activity
H7F24_RS14675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F24_RS14680	COG0243	molybdopterin cofactor binding
H7F24_RS14685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F24_RS14690	COG2223	nitrite transmembrane transporter activity
H7F24_RS14695	COG0493	'glutamate synthase
H7F24_RS14700	COG0070	glutamate synthase
H7F24_RS14700	COG0067	glutamate synthase
H7F24_RS14700	COG0069	glutamate synthase activity
H7F24_RS14705	COG0583	DNA-binding transcription factor activity
H7F24_RS14715	COG1132	(ABC) transporter
H7F24_RS14720	COG0789	Transcriptional regulator
H7F24_RS14720	COG4978	Transcriptional regulator
H7F24_RS14725	COG0454	-acetyltransferase
H7F24_RS14730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7F24_RS14735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7F24_RS14750	COG0243	molybdopterin cofactor binding
H7F24_RS14760	COG1070	Carbohydrate kinase
H7F24_RS14765	COG2115	Belongs to the xylose isomerase family
H7F24_RS14780	COG2211	Major facilitator Superfamily
H7F24_RS14785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F24_RS14790	COG1994	Peptidase M50
H7F24_RS14810	COG1309	transcriptional regulator
H7F24_RS14815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F24_RS14820	COG3708	Transcriptional regulator
H7F24_RS14825	COG2378	regulation of single-species biofilm formation
H7F24_RS14835	COG0640	Transcriptional regulator
H7F24_RS14840	COG0531	amino acid
H7F24_RS14845	COG0741	lytic transglycosylase activity
H7F24_RS14850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7F24_RS14855	COG2079	MmgE PrpD family protein
H7F24_RS14860	COG0372	Belongs to the citrate synthase family
H7F24_RS14865	COG2322	membrane
H7F24_RS14875	COG1388	LysM domain
H7F24_RS14875	COG3584	3D domain protein
H7F24_RS14880	COG0514	ATP-dependent DNA helicase (RecQ)
H7F24_RS14890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7F24_RS14915	COG1012	belongs to the aldehyde dehydrogenase family
H7F24_RS14920	COG1657	PFAM Prenyltransferase squalene oxidase
H7F24_RS14925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7F24_RS14930	COG0385	Bile acid
H7F24_RS14935	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F24_RS14940	COG0567	Dehydrogenase, E1 component
H7F24_RS14945	COG4548	von Willebrand factor, type A
H7F24_RS14950	COG0714	Associated with various cellular activities
H7F24_RS14955	COG2032	superoxide dismutase activity
H7F24_RS14960	COG0791	NLP P60 protein
H7F24_RS14960	COG1388	LysM domain
H7F24_RS14965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H7F24_RS14970	COG0534	Mate efflux family protein
H7F24_RS14975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F24_RS14980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F24_RS14990	COG2962	Rard protein
H7F24_RS15005	COG1733	regulation of RNA biosynthetic process
H7F24_RS15010	COG0778	Nitroreductase
H7F24_RS15020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F24_RS15025	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7F24_RS15030	COG3409	Peptidoglycan-binding domain 1 protein
H7F24_RS15030	COG0793	Belongs to the peptidase S41A family
H7F24_RS15035	COG2226	methyltransferase
H7F24_RS15045	COG1876	peptidase activity
H7F24_RS15050	COG0813	purine-nucleoside phosphorylase activity
H7F24_RS15060	COG0671	phosphoesterase, PA-phosphatase related
H7F24_RS15075	COG4479	Belongs to the UPF0346 family
H7F24_RS15085	COG1509	lysine 2,3-aminomutase activity
H7F24_RS15090	COG3829	transcription factor binding
H7F24_RS15095	COG0463	Glycosyl transferase, family 2
H7F24_RS15110	COG4641	Protein conserved in bacteria
H7F24_RS15120	COG1086	Polysaccharide biosynthesis protein
H7F24_RS15125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7F24_RS15130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7F24_RS15135	COG1846	Transcriptional regulator
H7F24_RS15155	COG4698	Protein conserved in bacteria
H7F24_RS15160	COG2755	lipolytic protein G-D-S-L family
H7F24_RS15165	COG1999	signal sequence binding
H7F24_RS15180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7F24_RS15185	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7F24_RS15190	COG1272	protein, Hemolysin III
H7F24_RS15195	COG0204	Acyl-transferase
H7F24_RS15200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7F24_RS15205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7F24_RS15210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7F24_RS15220	COG2136	Putative SAM-dependent methyltransferase
H7F24_RS15220	COG2521	methyltransferase
H7F24_RS15230	COG0129	dihydroxy-acid dehydratase activity
H7F24_RS15235	COG1413	lyase activity
H7F24_RS15240	COG1418	mRNA catabolic process
H7F24_RS15245	COG0386	Belongs to the glutathione peroxidase family
H7F24_RS15250	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7F24_RS15255	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7F24_RS15260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7F24_RS15270	COG1278	Cold shock
H7F24_RS15285	COG0328	RNA-DNA hybrid ribonuclease activity
H7F24_RS15290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7F24_RS15295	COG0328	RNA-DNA hybrid ribonuclease activity
H7F24_RS15305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F24_RS15315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H7F24_RS15325	COG1755	Isoprenylcysteine carboxyl methyltransferase
H7F24_RS15330	COG3424	synthase
H7F24_RS15340	COG0726	polysaccharide deacetylase
H7F24_RS15345	COG2233	PERMEase
H7F24_RS15350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7F24_RS15355	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7F24_RS15360	COG1199	ATP-dependent helicase activity
H7F24_RS15370	COG0116	Belongs to the methyltransferase superfamily
H7F24_RS15380	COG3599	regulation of cell shape
H7F24_RS15385	COG4474	Belongs to the UPF0398 family
H7F24_RS15395	COG3359	exonuclease
H7F24_RS15400	COG1205	dead DEAH box helicase
H7F24_RS15400	COG1111	helicase
H7F24_RS15405	COG1902	pentaerythritol trinitrate reductase activity
H7F24_RS15410	COG2190	(PTS) system
H7F24_RS15415	COG0071	Belongs to the small heat shock protein (HSP20) family
H7F24_RS15445	COG3331	DNA recombination
H7F24_RS15450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F24_RS15450	COG4499	WXG100 protein secretion system (Wss), protein YukC
H7F24_RS15460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7F24_RS15465	COG3935	DnaD domain protein
H7F24_RS15470	COG0017	Asparaginyl-tRNA synthetase
H7F24_RS15475	COG5353	protein conserved in bacteria
H7F24_RS15485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7F24_RS15485	COG1199	ATP-dependent helicase activity
H7F24_RS15490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H7F24_RS15495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7F24_RS15500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7F24_RS15510	COG0617	tRNA 3'-terminal CCA addition
H7F24_RS15515	COG0438	transferase activity, transferring glycosyl groups
H7F24_RS15520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F24_RS15525	COG1803	Methylglyoxal synthase
H7F24_RS15530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7F24_RS15535	COG1694	Mazg nucleotide pyrophosphohydrolase
H7F24_RS15540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F24_RS15550	COG4347	Protein of unknown function (DUF1405)
H7F24_RS15555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7F24_RS15555	COG2010	Cytochrome c
H7F24_RS15560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7F24_RS15565	COG0723	plastoquinol--plastocyanin reductase activity
H7F24_RS15575	COG5582	Belongs to the UPF0302 family
H7F24_RS15580	COG0457	Tetratricopeptide repeat
H7F24_RS15585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7F24_RS15590	COG0287	Prephenate dehydrogenase
H7F24_RS15595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7F24_RS15600	COG0159	tryptophan synthase activity
H7F24_RS15605	COG0133	tryptophan synthase activity
H7F24_RS15615	COG0134	indole-3-glycerol-phosphate synthase activity
H7F24_RS15630	COG4401	Chorismate mutase type I
H7F24_RS15635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7F24_RS15640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7F24_RS15645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7F24_RS15650	COG0105	UTP biosynthetic process
H7F24_RS15655	COG0142	geranyltranstransferase activity
H7F24_RS15660	COG2226	methyltransferase
H7F24_RS15665	COG0142	geranyltranstransferase activity
H7F24_RS15675	COG0302	gtp cyclohydrolase
H7F24_RS15680	COG0776	regulation of translation
H7F24_RS15685	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H7F24_RS15700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7F24_RS15705	COG1160	GTP binding
H7F24_RS15730	COG1304	FMN binding
H7F24_RS15735	COG0539	negative regulation of cytoplasmic translation
H7F24_RS15740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7F24_RS15750	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H7F24_RS15755	COG2959	enzyme of heme biosynthesis
H7F24_RS15760	COG3773	Cell wall hydrolase
H7F24_RS15760	COG3409	Peptidoglycan-binding domain 1 protein
H7F24_RS15765	COG2339	peptidase activity
H7F24_RS15770	COG0492	ferredoxin-NADP+ reductase activity
H7F24_RS15775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F24_RS15780	COG4862	establishment of competence for transformation
H7F24_RS15785	COG1408	metallophosphoesterase
H7F24_RS15795	COG1388	LysM domain
H7F24_RS15800	COG1266	CAAX protease self-immunity
H7F24_RS15805	COG0514	ATP-dependent DNA helicase (RecQ)
H7F24_RS15810	COG4955	Helix-turn-helix domain
H7F24_RS15815	COG1141	Ferredoxin
H7F24_RS15820	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H7F24_RS15825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7F24_RS15830	COG3409	Peptidoglycan-binding domain 1 protein
H7F24_RS15830	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS15840	COG1595	DNA-templated transcription, initiation
H7F24_RS15845	COG5002	protein histidine kinase activity
H7F24_RS15850	COG0745	RESPONSE REGULATOR receiver
H7F24_RS15855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7F24_RS15860	COG1333	cytochrome c biogenesis protein
H7F24_RS15865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F24_RS15870	COG1187	pseudouridine synthase activity
H7F24_RS15875	COG0700	Nucleoside recognition
H7F24_RS15880	COG2715	membrane protein required for spore maturation
H7F24_RS15885	COG1686	Belongs to the peptidase S11 family
H7F24_RS15895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7F24_RS15900	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7F24_RS15910	COG1547	Domain of unknown function (DUF309)
H7F24_RS15915	COG0456	acetyltransferase
H7F24_RS15920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7F24_RS15925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F24_RS15925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F24_RS15930	COG0307	riboflavin synthase, alpha
H7F24_RS15950	COG2814	Major facilitator Superfamily
H7F24_RS15955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7F24_RS15960	COG4086	secreted protein
H7F24_RS15965	COG0019	diaminopimelate decarboxylase activity
H7F24_RS15970	COG0697	spore germination
H7F24_RS15985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F24_RS16005	COG1191	sigma factor activity
H7F24_RS16010	COG2172	sigma factor antagonist activity
H7F24_RS16020	COG1686	Belongs to the peptidase S11 family
H7F24_RS16025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7F24_RS16030	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7F24_RS16035	COG4974	Belongs to the 'phage' integrase family
H7F24_RS16045	COG0735	belongs to the Fur family
H7F24_RS16050	COG1300	Membrane
H7F24_RS16055	COG1404	Belongs to the peptidase S8 family
H7F24_RS16065	COG2153	protein acetylation
H7F24_RS16070	COG1379	DNA repair
H7F24_RS16075	COG0494	nUDIX hydrolase
H7F24_RS16080	COG0667	Aldo Keto reductase
H7F24_RS16095	COG1073	alpha beta
H7F24_RS16100	COG0457	Tetratricopeptide repeat
H7F24_RS16115	COG4918	Iron-sulphur cluster biosynthesis
H7F24_RS16120	COG0456	acetyltransferase
H7F24_RS16120	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H7F24_RS16125	COG0456	acetyltransferase
H7F24_RS16135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7F24_RS16145	COG2211	Major facilitator Superfamily
H7F24_RS16150	COG1072	(Pantothenic acid kinase))
H7F24_RS16155	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7F24_RS16160	COG0300	oxidoreductase activity
H7F24_RS16165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F24_RS16170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F24_RS16180	COG4187	Peptidase family M20/M25/M40
H7F24_RS16185	COG1902	pentaerythritol trinitrate reductase activity
H7F24_RS16190	COG0596	Alpha beta hydrolase
H7F24_RS16195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F24_RS16205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7F24_RS16210	COG2188	Transcriptional regulator
H7F24_RS16215	COG2723	6-phospho-beta-galactosidase activity
H7F24_RS16220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F24_RS16225	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7F24_RS16230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F24_RS16235	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS16245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H7F24_RS16250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7F24_RS16265	COG0706	membrane insertase activity
H7F24_RS16275	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7F24_RS16280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7F24_RS16285	COG0346	lactoylglutathione lyase activity
H7F24_RS16295	COG1376	ErfK ybiS ycfS ynhG family protein
H7F24_RS16300	COG4129	membrane
H7F24_RS16305	COG1126	abc transporter atp-binding protein
H7F24_RS16310	COG0765	amino acid transport
H7F24_RS16315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F24_RS16325	COG1597	lipid kinase activity
H7F24_RS16335	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F24_RS16340	COG0022	dehydrogenase e1 component
H7F24_RS16345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F24_RS16350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F24_RS16355	COG3426	butyrate kinase activity
H7F24_RS16360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F24_RS16365	COG0280	phosphate acetyltransferase
H7F24_RS16370	COG3290	protein histidine kinase activity
H7F24_RS16370	COG3829	transcription factor binding
H7F24_RS16380	COG0584	glycerophosphoryl diester phosphodiesterase
H7F24_RS16385	COG0457	Tetratricopeptide repeat
H7F24_RS16395	COG0745	RESPONSE REGULATOR receiver
H7F24_RS16400	COG0750	zinc metalloprotease
H7F24_RS16405	COG0497	DNA recombination
H7F24_RS16410	COG1438	arginine binding
H7F24_RS16415	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H7F24_RS16420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7F24_RS16425	COG0142	geranyltranstransferase activity
H7F24_RS16430	COG1722	exodeoxyribonuclease VII activity
H7F24_RS16435	COG1570	exodeoxyribonuclease VII activity
H7F24_RS16440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7F24_RS16445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7F24_RS16450	COG1302	Protein conserved in bacteria
H7F24_RS16455	COG0439	Biotin carboxylase
H7F24_RS16460	COG0511	ligase activity, forming carbon-carbon bonds
H7F24_RS16500	COG3854	ATPases associated with a variety of cellular activities
H7F24_RS16510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7F24_RS16515	COG0006	proline dipeptidase activity
H7F24_RS16520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7F24_RS16530	COG3872	metal-dependent enzyme
H7F24_RS16540	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7F24_RS16545	COG1321	iron dependent repressor
H7F24_RS16550	COG0095	Lipoate-protein ligase
H7F24_RS16555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F24_RS16560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7F24_RS16565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7F24_RS16570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7F24_RS16575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7F24_RS16600	COG0681	Belongs to the peptidase S26 family
H7F24_RS16635	COG4970	Tfp pilus assembly protein FimT
H7F24_RS16640	COG4537	Required for transformation and DNA binding
H7F24_RS16645	COG1459	type II secretion system
H7F24_RS16650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7F24_RS16655	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F24_RS16665	COG1393	Belongs to the ArsC family
H7F24_RS16675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F24_RS16685	COG0011	TIGRFAM Protein of
H7F24_RS16690	COG2814	Major facilitator Superfamily
H7F24_RS16695	COG2866	Carboxypeptidase
H7F24_RS16700	COG1368	sulfuric ester hydrolase activity
H7F24_RS16705	COG1940	carbohydrate kinase activity
H7F24_RS16710	COG4483	Protein conserved in bacteria
H7F24_RS16715	COG0457	Tetratricopeptide repeat
H7F24_RS16715	COG0705	Rhomboid family
H7F24_RS16725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7F24_RS16730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7F24_RS16740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7F24_RS16745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7F24_RS16750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7F24_RS16755	COG0581	inorganic phosphate transmembrane transporter activity
H7F24_RS16760	COG0573	inorganic phosphate transmembrane transporter activity
H7F24_RS16765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7F24_RS16770	COG0768	penicillin binding
H7F24_RS16775	COG0477	Major facilitator Superfamily
H7F24_RS16780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7F24_RS16785	COG2839	Protein conserved in bacteria
H7F24_RS16790	COG5521	maltodextrose utilization protein MalA
H7F24_RS16795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F24_RS16800	COG1388	LysM domain
H7F24_RS16805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7F24_RS16810	COG4709	membrane
H7F24_RS16815	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H7F24_RS16820	COG1940	carbohydrate kinase activity
H7F24_RS16825	COG0735	belongs to the Fur family
H7F24_RS16830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7F24_RS16835	COG1121	(ABC) transporter
H7F24_RS16840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F24_RS16855	COG0513	Belongs to the DEAD box helicase family
H7F24_RS16865	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7F24_RS16870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7F24_RS16875	COG2384	SAM-dependent methyltransferase
H7F24_RS16880	COG2010	Cytochrome c
H7F24_RS16885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7F24_RS16890	COG0358	DNA primase activity
H7F24_RS16895	COG1671	Belongs to the UPF0178 family
H7F24_RS16900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7F24_RS16905	COG0517	IMP dehydrogenase activity
H7F24_RS16910	COG0751	glycine-tRNA ligase activity
H7F24_RS16915	COG0752	glycyl-tRNA synthetase alpha subunit
H7F24_RS16920	COG1381	Involved in DNA repair and RecF pathway recombination
H7F24_RS16930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7F24_RS16935	COG0295	cytidine deaminase activity
H7F24_RS16940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7F24_RS16945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7F24_RS16950	COG1480	7TM receptor with intracellular HD hydrolase
H7F24_RS16955	COG1702	phosphate starvation-inducible protein PhoH
H7F24_RS16960	COG0561	phosphatase activity
H7F24_RS16975	COG4864	UPF0365 protein
H7F24_RS16980	COG1030	water channel activity
H7F24_RS16985	COG1610	YqeY-like protein
H7F24_RS16995	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7F24_RS17000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7F24_RS17005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7F24_RS17010	COG2264	protein methyltransferase activity
H7F24_RS17015	COG0484	heat shock protein binding
H7F24_RS17020	COG0443	Heat shock 70 kDa protein
H7F24_RS17025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7F24_RS17030	COG1420	regulation of RNA biosynthetic process
H7F24_RS17035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7F24_RS17040	COG0481	GTPase activity
H7F24_RS17050	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS17055	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7F24_RS17060	COG0268	Binds directly to 16S ribosomal RNA
H7F24_RS17065	COG1466	dna polymerase III delta subunit
H7F24_RS17075	COG2333	competence protein COMEC
H7F24_RS17075	COG0658	competence protein
H7F24_RS17080	COG2131	deaminase
H7F24_RS17085	COG1555	photosystem II stabilization
H7F24_RS17090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F24_RS17095	COG2226	methyltransferase
H7F24_RS17100	COG0799	negative regulation of ribosome biogenesis
H7F24_RS17105	COG1713	HD superfamily hydrolase involved in NAD metabolism
H7F24_RS17110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7F24_RS17115	COG1534	Rna-binding protein
H7F24_RS17120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7F24_RS17125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7F24_RS17130	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H7F24_RS17145	COG2755	lipolytic protein G-D-S-L family
H7F24_RS17155	COG0457	Tetratricopeptide repeat
H7F24_RS17165	COG2186	Transcriptional regulator
H7F24_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS17185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7F24_RS17190	COG3959	Transketolase, thiamine diphosphate binding domain
H7F24_RS17215	COG0726	polysaccharide deacetylase
H7F24_RS17250	COG1131	(ABC) transporter
H7F24_RS17270	COG2160	L-arabinose isomerase activity
H7F24_RS17285	COG1609	Transcriptional regulator
H7F24_RS17295	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7F24_RS17300	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H7F24_RS17305	COG1733	regulation of RNA biosynthetic process
H7F24_RS17310	COG0657	acetylesterase activity
H7F24_RS17325	COG1309	transcriptional regulator
H7F24_RS17330	COG0109	protoheme IX farnesyltransferase activity
H7F24_RS17335	COG2602	Beta-lactamase
H7F24_RS17340	COG1960	acyl-CoA dehydrogenase activity
H7F24_RS17345	COG1126	abc transporter atp-binding protein
H7F24_RS17355	COG0765	amino acid transport
H7F24_RS17365	COG3546	catalase activity
H7F24_RS17370	COG1063	alcohol dehydrogenase
H7F24_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS17390	COG1115	amino acid carrier protein
H7F24_RS17395	COG0583	DNA-binding transcription factor activity
H7F24_RS17400	COG0842	Transport permease protein
H7F24_RS17405	COG0842	Transport permease protein
H7F24_RS17405	COG1511	domain protein
H7F24_RS17410	COG1131	(ABC) transporter
H7F24_RS17415	COG2226	methyltransferase
H7F24_RS17420	COG1063	alcohol dehydrogenase
H7F24_RS17425	COG2226	methyltransferase
H7F24_RS17450	COG0626	cystathionine gamma-synthase activity
H7F24_RS17455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F24_RS17460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7F24_RS17465	COG2226	methyltransferase
H7F24_RS17480	COG0768	penicillin binding
H7F24_RS17485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7F24_RS17495	COG0572	uridine kinase
H7F24_RS17500	COG0826	peptidase U32
H7F24_RS17505	COG0826	peptidase U32
H7F24_RS17510	COG4122	O-methyltransferase activity
H7F24_RS17515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7F24_RS17520	COG0183	Belongs to the thiolase family
H7F24_RS17525	COG0318	PFAM AMP-dependent synthetase and ligase
H7F24_RS17530	COG1268	BioY protein
H7F24_RS17535	COG3906	Belongs to the UPF0473 family
H7F24_RS17540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7F24_RS17545	COG4472	Bacterial protein of unknown function (DUF965)
H7F24_RS17550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7F24_RS17555	COG0628	permease
H7F24_RS17560	COG1126	abc transporter atp-binding protein
H7F24_RS17565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F24_RS17570	COG0765	amino acid transport
H7F24_RS17575	COG0765	amino acid transport
H7F24_RS17590	COG3881	PFAM PRC-barrel domain
H7F24_RS17595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7F24_RS17600	COG0457	Tetratricopeptide repeat
H7F24_RS17605	COG0482	sulfurtransferase activity
H7F24_RS17610	COG1104	cysteine desulfurase activity
H7F24_RS17615	COG1959	2 iron, 2 sulfur cluster binding
H7F24_RS17620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7F24_RS17625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7F24_RS17640	COG0124	histidyl-tRNA synthetase
H7F24_RS17650	COG4991	sh3 domain protein
H7F24_RS17650	COG3103	Sh3 type 3 domain protein
H7F24_RS17650	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F24_RS17655	COG1490	D-aminoacyl-tRNA deacylase activity
H7F24_RS17660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7F24_RS17665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7F24_RS17670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7F24_RS17670	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H7F24_RS17675	COG5416	Lipopolysaccharide assembly protein A domain
H7F24_RS17680	COG0490	domain, Protein
H7F24_RS17685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7F24_RS17685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7F24_RS17695	COG2244	polysaccharide biosynthetic process
H7F24_RS17700	COG2323	membrane
H7F24_RS17710	COG1862	Preprotein translocase
H7F24_RS17715	COG0343	queuine tRNA-ribosyltransferase activity
H7F24_RS17720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7F24_RS17730	COG2255	four-way junction helicase activity
H7F24_RS17735	COG0632	four-way junction helicase activity
H7F24_RS17745	COG2112	serine threonine protein kinase
H7F24_RS17760	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7F24_RS17775	COG1388	LysM domain
H7F24_RS17775	COG1388	LysM domain
H7F24_RS17780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7F24_RS17785	COG0157	Belongs to the NadC ModD family
H7F24_RS17790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7F24_RS17795	COG1104	cysteine desulfurase activity
H7F24_RS17800	COG1827	regulation of RNA biosynthetic process
H7F24_RS17805	COG0077	Prephenate dehydratase
H7F24_RS17810	COG4492	Belongs to the UPF0735 family
H7F24_RS17815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7F24_RS17820	COG3290	protein histidine kinase activity
H7F24_RS17825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7F24_RS17830	COG2868	ribosomal protein
H7F24_RS17835	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7F24_RS17840	COG1994	Peptidase M50
H7F24_RS17845	COG0739	heme binding
H7F24_RS17850	COG2894	cell division
H7F24_RS17855	COG0850	regulation of cytokinetic process
H7F24_RS17860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7F24_RS17870	COG1077	Cell shape determining protein MreB Mrl
H7F24_RS17875	COG2003	Belongs to the UPF0758 family
H7F24_RS17880	COG0424	maF-like protein
H7F24_RS17890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7F24_RS17895	COG0285	dihydrofolate synthase activity
H7F24_RS17900	COG0525	valine-tRNA ligase activity
H7F24_RS17905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7F24_RS17910	COG1388	LysM domain
H7F24_RS17915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7F24_RS17920	COG0113	porphobilinogen synthase activity
H7F24_RS17925	COG1587	Uroporphyrinogen-III synthase
H7F24_RS17930	COG0181	hydroxymethylbilane synthase activity
H7F24_RS17935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7F24_RS17940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7F24_RS17950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7F24_RS17955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7F24_RS17960	COG1067	ATP-dependent peptidase activity
H7F24_RS17960	COG0470	DNA polymerase III
H7F24_RS17965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7F24_RS17970	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7F24_RS17975	COG0457	Tetratricopeptide repeat
H7F24_RS17975	COG1477	protein flavinylation
H7F24_RS17980	COG0066	3-isopropylmalate dehydratase activity
H7F24_RS17985	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7F24_RS17990	COG0473	3-isopropylmalate dehydrogenase activity
H7F24_RS17995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7F24_RS18000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7F24_RS18005	COG0440	acetolactate synthase activity
H7F24_RS18010	COG0028	Belongs to the TPP enzyme family
H7F24_RS18015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F24_RS18020	COG2706	6-phosphogluconolactonase activity
H7F24_RS18025	COG3339	Conserved Protein
H7F24_RS18030	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H7F24_RS18035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F24_RS18040	COG1696	Membrane protein involved in D-alanine export
H7F24_RS18090	COG0622	Phosphoesterase
H7F24_RS18095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7F24_RS18100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7F24_RS18105	COG5401	PFAM Sporulation and spore germination
H7F24_RS18110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7F24_RS18115	COG1846	Transcriptional regulator
H7F24_RS18120	COG2197	response regulator
H7F24_RS18125	COG2851	Citrate transporter
H7F24_RS18130	COG0583	DNA-binding transcription factor activity
H7F24_RS18135	COG2828	Protein conserved in bacteria
H7F24_RS18145	COG0824	Thioesterase
H7F24_RS18150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7F24_RS18155	COG1053	succinate dehydrogenase
H7F24_RS18160	COG2009	succinate dehydrogenase
H7F24_RS18165	COG1719	4-vinyl reductase, 4VR
H7F24_RS18170	COG0527	aspartate kinase activity
H7F24_RS18175	COG0322	excinuclease ABC activity
H7F24_RS18180	COG3118	belongs to the thioredoxin family
H7F24_RS18185	COG3534	alpha-L-arabinofuranosidase
H7F24_RS18190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7F24_RS18195	COG2086	electron transfer activity
H7F24_RS18200	COG1024	Enoyl-CoA hydratase
H7F24_RS18205	COG1309	transcriptional regulator
H7F24_RS18210	COG0318	PFAM AMP-dependent synthetase and ligase
H7F24_RS18220	COG3766	membrane
H7F24_RS18225	COG1193	negative regulation of DNA recombination
H7F24_RS18230	COG1796	DNA polymerase
H7F24_RS18230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7F24_RS18235	COG1286	toxin biosynthetic process
H7F24_RS18240	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H7F24_RS18245	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7F24_RS18255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F24_RS18255	COG0072	phenylalanine-tRNA ligase activity
H7F24_RS18260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7F24_RS18265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7F24_RS18275	COG1966	Carbon starvation protein
H7F24_RS18280	COG1363	Peptidase, m42
H7F24_RS18290	COG3326	Membrane
H7F24_RS18295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7F24_RS18300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7F24_RS18305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7F24_RS18310	COG1346	cytolysis
H7F24_RS18320	COG3279	Response regulator of the LytR AlgR family
H7F24_RS18325	COG3275	phosphorelay sensor kinase activity
H7F24_RS18330	COG1011	Hydrolase
H7F24_RS18340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7F24_RS18350	COG0398	Pfam SNARE associated Golgi protein
H7F24_RS18355	COG1484	DNA-dependent DNA replication
H7F24_RS18360	COG3611	Membrane attachment protein
H7F24_RS18365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7F24_RS18375	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H7F24_RS18380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7F24_RS18385	COG0237	dephospho-CoA kinase activity
H7F24_RS18390	COG1971	Probably functions as a manganese efflux pump
H7F24_RS18395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7F24_RS18400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F24_RS18400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F24_RS18405	COG5002	protein histidine kinase activity
H7F24_RS18410	COG0745	RESPONSE REGULATOR receiver
H7F24_RS18415	COG0039	L-malate dehydrogenase activity
H7F24_RS18420	COG0538	isocitrate dehydrogenase activity
H7F24_RS18425	COG0372	Belongs to the citrate synthase family
H7F24_RS18430	COG2707	UPF0756 membrane protein
H7F24_RS18435	COG0628	permease
H7F24_RS18440	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7F24_RS18450	COG0205	6-phosphofructokinase activity
H7F24_RS18455	COG0825	malonyl-CoA metabolic process
H7F24_RS18460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7F24_RS18465	COG0281	malic enzyme
H7F24_RS18470	COG0587	DNA-directed DNA polymerase activity
H7F24_RS18490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7F24_RS18500	COG4109	DRTGG domain
H7F24_RS18505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7F24_RS18510	COG1028	Short-chain dehydrogenase reductase Sdr
H7F24_RS18520	COG0165	Argininosuccinate lyase
H7F24_RS18525	COG0137	argininosuccinate synthase activity
H7F24_RS18530	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7F24_RS18535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7F24_RS18540	COG0827	DNA restriction-modification system
H7F24_RS18545	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H7F24_RS18550	COG3874	Sporulation protein YtfJ
H7F24_RS18560	COG1714	RDD family
H7F24_RS18565	COG0616	signal peptide processing
H7F24_RS18570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7F24_RS18580	COG3239	Fatty acid desaturase
H7F24_RS18585	COG4585	Histidine kinase
H7F24_RS18590	COG2197	response regulator
H7F24_RS18595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F24_RS18600	COG0745	RESPONSE REGULATOR receiver
H7F24_RS18605	COG0642	Histidine kinase
H7F24_RS18610	COG1136	(ABC) transporter
H7F24_RS18615	COG0577	efflux transmembrane transporter activity
H7F24_RS18620	COG0402	S-adenosylhomocysteine deaminase activity
H7F24_RS18635	COG1279	arginine transmembrane transporter activity
H7F24_RS18655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7F24_RS18665	COG0301	tRNA thio-modification
H7F24_RS18670	COG1104	cysteine desulfurase activity
H7F24_RS18675	COG1114	Component of the transport system for branched-chain amino acids
H7F24_RS18680	COG1114	Component of the transport system for branched-chain amino acids
H7F24_RS18685	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H7F24_RS18690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7F24_RS18695	COG1309	transcriptional regulator
H7F24_RS18700	COG1956	GAF domain-containing protein
H7F24_RS18705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7F24_RS18710	COG1335	isochorismatase
H7F24_RS18720	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7F24_RS18725	COG2329	Antibiotic biosynthesis monooxygenase
H7F24_RS18730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7F24_RS18735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7F24_RS18740	COG0454	-acetyltransferase
H7F24_RS18745	COG0517	IMP dehydrogenase activity
H7F24_RS18750	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7F24_RS18755	COG1609	Transcriptional regulator
H7F24_RS18760	COG1605	Chorismate mutase
H7F24_RS18760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H7F24_RS18765	COG3118	belongs to the thioredoxin family
H7F24_RS18770	COG4980	gas vesicle protein
H7F24_RS18775	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H7F24_RS18780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7F24_RS18785	COG1674	ftsk spoiiie
H7F24_RS18790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F24_RS18795	COG4848	Belongs to the UPF0354 family
H7F24_RS18800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F24_RS18815	COG1363	Peptidase, m42
H7F24_RS18820	COG5584	Small secreted protein
H7F24_RS18825	COG0281	malic enzyme
H7F24_RS18830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F24_RS18835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7F24_RS18845	COG0510	thiamine kinase activity
H7F24_RS18850	COG1597	lipid kinase activity
H7F24_RS18860	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H7F24_RS18865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F24_RS18870	COG3340	Belongs to the peptidase S51 family
H7F24_RS18875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7F24_RS18880	COG2252	PERMEase
H7F24_RS18885	COG1349	DNA-binding transcription factor activity
H7F24_RS18890	COG1187	pseudouridine synthase activity
H7F24_RS18895	COG2244	polysaccharide biosynthetic process
H7F24_RS18900	COG2081	HI0933 family
H7F24_RS18910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7F24_RS18915	COG3196	Protein conserved in bacteria
H7F24_RS18925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F24_RS18930	COG5578	integral membrane protein
H7F24_RS18935	COG0673	inositol 2-dehydrogenase activity
H7F24_RS18940	COG1653	transport
H7F24_RS18945	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H7F24_RS18950	COG4209	transmembrane transport
H7F24_RS18955	COG2207	Transcriptional regulator
H7F24_RS18960	COG1733	regulation of RNA biosynthetic process
H7F24_RS18965	COG2814	Major facilitator Superfamily
H7F24_RS18970	COG0656	L-ascorbic acid biosynthetic process
H7F24_RS18975	COG1653	transport
H7F24_RS18980	COG0395	ABC-type sugar transport system, permease component
H7F24_RS18985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F24_RS18990	COG1073	alpha beta
H7F24_RS18995	COG0495	leucyl-tRNA aminoacylation
H7F24_RS19005	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F24_RS19005	COG2202	Pas domain
H7F24_RS19010	COG2433	Pfam Transposase IS66
H7F24_RS19015	COG0577	efflux transmembrane transporter activity
H7F24_RS19020	COG1136	(ABC) transporter
H7F24_RS19030	COG1131	(ABC) transporter
H7F24_RS19035	COG1725	Transcriptional regulator
H7F24_RS19050	COG1242	4 iron, 4 sulfur cluster binding
H7F24_RS19055	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H7F24_RS19065	COG2267	carboxylic ester hydrolase activity
H7F24_RS19070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7F24_RS19075	COG0367	asparagine synthase
H7F24_RS19080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7F24_RS19085	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7F24_RS19095	COG1506	peptidase
H7F24_RS19100	COG1233	COG1233 Phytoene dehydrogenase and related
H7F24_RS19120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7F24_RS19125	COG1116	anion transmembrane transporter activity
H7F24_RS19130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7F24_RS19135	COG0494	nUDIX hydrolase
H7F24_RS19140	COG2310	stress, protein
H7F24_RS19155	COG4824	toxin secretion phage lysis holin
H7F24_RS19165	COG0783	Belongs to the Dps family
H7F24_RS19180	COG1854	S-ribosylhomocysteine lyase activity
H7F24_RS19185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7F24_RS19190	COG0288	reversible hydration of carbon dioxide
H7F24_RS19195	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7F24_RS19195	COG3443	Belongs to the bacterial solute-binding protein 9 family
H7F24_RS19210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7F24_RS19215	COG1854	S-ribosylhomocysteine lyase activity
H7F24_RS19240	COG4824	toxin secretion phage lysis holin
H7F24_RS19255	COG2310	stress, protein
H7F24_RS19260	COG0494	nUDIX hydrolase