locus-tag	class	description
H7F27_RS00010	COG3870	Protein conserved in bacteria
H7F27_RS00015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7F27_RS00020	COG1982	Orn Lys Arg decarboxylase major
H7F27_RS00025	COG3853	Toxic anion resistance protein (TelA)
H7F27_RS00030	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
H7F27_RS00075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7F27_RS00080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7F27_RS00085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7F27_RS00095	COG0590	tRNA wobble adenosine to inosine editing
H7F27_RS00100	COG1335	isochorismatase
H7F27_RS00105	COG1388	LysM domain
H7F27_RS00105	COG3858	chitin binding
H7F27_RS00110	COG1428	Deoxynucleoside kinase
H7F27_RS00115	COG1428	Deoxynucleoside kinase
H7F27_RS00125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7F27_RS00130	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H7F27_RS00140	COG1686	Belongs to the peptidase S11 family
H7F27_RS00145	COG0516	GMP reductase activity
H7F27_RS00145	COG0517	IMP dehydrogenase activity
H7F27_RS00180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7F27_RS00195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7F27_RS00200	COG2501	S4 domain
H7F27_RS00205	COG0592	DNA-directed DNA polymerase activity
H7F27_RS00210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7F27_RS00220	COG0594	ribonuclease P activity
H7F27_RS00225	COG0706	membrane insertase activity
H7F27_RS00230	COG1847	R3H domain protein
H7F27_RS00235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7F27_RS00240	COG0445	tRNA wobble uridine modification
H7F27_RS00245	COG0357	Ribosomal RNA small subunit methyltransferase G
H7F27_RS00250	COG1475	DNA binding
H7F27_RS00260	COG1192	Involved in chromosome partitioning
H7F27_RS00265	COG1475	DNA binding
H7F27_RS00275	COG3949	Membrane
H7F27_RS00280	COG4481	Protein conserved in bacteria
H7F27_RS00285	COG0243	molybdopterin cofactor binding
H7F27_RS00290	COG0012	GTP binding
H7F27_RS00295	COG0360	Binds together with S18 to 16S ribosomal RNA
H7F27_RS00300	COG0629	single-stranded DNA binding
H7F27_RS00310	COG0708	Exodeoxyribonuclease III
H7F27_RS00315	COG1609	Transcriptional regulator
H7F27_RS00320	COG0346	lactoylglutathione lyase activity
H7F27_RS00325	COG0110	maltose O-acetyltransferase activity
H7F27_RS00330	COG2814	Major facilitator Superfamily
H7F27_RS00330	COG0477	Major facilitator Superfamily
H7F27_RS00335	COG1266	CAAX protease self-immunity
H7F27_RS00340	COG1331	Highly conserved protein containing a thioredoxin domain
H7F27_RS00350	COG2856	Zn peptidase
H7F27_RS00355	COG1396	sequence-specific DNA binding
H7F27_RS00380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F27_RS00400	COG2207	Transcriptional regulator
H7F27_RS00400	COG3708	Transcriptional regulator
H7F27_RS00405	COG1811	Na channel or pump
H7F27_RS00410	COG4978	Transcriptional regulator
H7F27_RS00410	COG0789	Transcriptional regulator
H7F27_RS00415	COG1309	transcriptional regulator
H7F27_RS00430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7F27_RS00435	COG0640	Transcriptional regulator
H7F27_RS00445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F27_RS00460	COG0583	DNA-binding transcription factor activity
H7F27_RS00470	COG2153	protein acetylation
H7F27_RS00475	COG0583	DNA-binding transcription factor activity
H7F27_RS00480	COG2814	Major facilitator Superfamily
H7F27_RS00485	COG1357	PFAM Pentapeptide repeats (8 copies)
H7F27_RS00490	COG4319	ketosteroid isomerase
H7F27_RS00500	COG0789	Transcriptional regulator
H7F27_RS00500	COG4978	Transcriptional regulator
H7F27_RS00505	COG2271	Major facilitator Superfamily
H7F27_RS00520	COG1227	inorganic diphosphatase activity
H7F27_RS00530	COG5577	PFAM Coat F domain
H7F27_RS00540	COG4241	membrane
H7F27_RS00545	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H7F27_RS00550	COG0359	binds to the 23S rRNA
H7F27_RS00555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7F27_RS00560	COG2807	transmembrane transport
H7F27_RS00565	COG3093	addiction module antidote protein HigA
H7F27_RS00580	COG0305	Participates in initiation and elongation during chromosome replication
H7F27_RS00585	COG0346	lactoylglutathione lyase activity
H7F27_RS00615	COG0745	RESPONSE REGULATOR receiver
H7F27_RS00620	COG5002	protein histidine kinase activity
H7F27_RS00625	COG4863	YycH protein
H7F27_RS00630	COG4853	Protein conserved in bacteria
H7F27_RS00635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7F27_RS00640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F27_RS00645	COG3829	transcription factor binding
H7F27_RS00650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7F27_RS00655	COG0833	amino acid
H7F27_RS00660	COG0010	Belongs to the arginase family
H7F27_RS00670	COG0457	Tetratricopeptide repeat
H7F27_RS00675	COG0456	acetyltransferase
H7F27_RS00680	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
H7F27_RS00700	COG1063	alcohol dehydrogenase
H7F27_RS00715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7F27_RS00735	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H7F27_RS00745	COG2188	Transcriptional regulator
H7F27_RS00750	COG1263	PTS System
H7F27_RS00750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS00750	COG2190	(PTS) system
H7F27_RS00755	COG2723	6-phospho-beta-galactosidase activity
H7F27_RS00765	COG3634	alkyl hydroperoxide reductase activity
H7F27_RS00770	COG0450	alkyl hydroperoxide reductase
H7F27_RS00775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H7F27_RS00780	COG2610	gluconate transmembrane transporter activity
H7F27_RS00785	COG1070	Carbohydrate kinase
H7F27_RS00790	COG1802	Transcriptional regulator
H7F27_RS00795	COG1929	Belongs to the glycerate kinase type-1 family
H7F27_RS00800	COG5039	Polysaccharide pyruvyl transferase
H7F27_RS00820	COG1346	cytolysis
H7F27_RS00825	COG1380	Effector of murein hydrolase LrgA
H7F27_RS00830	COG1846	Transcriptional regulator
H7F27_RS00835	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS00840	COG1309	transcriptional regulator
H7F27_RS00845	COG1917	Cupin 2, conserved barrel domain protein
H7F27_RS00850	COG2311	Membrane
H7F27_RS00855	COG1714	RDD family
H7F27_RS00860	COG0789	Transcriptional regulator
H7F27_RS00870	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS00875	COG1309	transcriptional regulator
H7F27_RS00910	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS00920	COG0326	Molecular chaperone. Has ATPase activity
H7F27_RS00925	COG2814	Major facilitator Superfamily
H7F27_RS00950	COG0667	Aldo Keto reductase
H7F27_RS00955	COG1349	DNA-binding transcription factor activity
H7F27_RS00960	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS00970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F27_RS00975	COG3962	Belongs to the TPP enzyme family
H7F27_RS00980	COG1082	Xylose isomerase domain protein TIM barrel
H7F27_RS00985	COG2814	Major facilitator Superfamily
H7F27_RS00990	COG0673	inositol 2-dehydrogenase activity
H7F27_RS00995	COG1082	Xylose isomerase domain protein TIM barrel
H7F27_RS01005	COG0191	fructose-bisphosphate aldolase activity
H7F27_RS01010	COG0745	RESPONSE REGULATOR receiver
H7F27_RS01015	COG2205	protein histidine kinase activity
H7F27_RS01020	COG1136	(ABC) transporter
H7F27_RS01025	COG0577	efflux transmembrane transporter activity
H7F27_RS01030	COG5294	Protein conserved in bacteria
H7F27_RS01035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F27_RS01065	COG0561	phosphatase activity
H7F27_RS01070	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H7F27_RS01080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F27_RS01085	COG0456	acetyltransferase
H7F27_RS01090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F27_RS01095	COG0765	amino acid transport
H7F27_RS01100	COG1126	abc transporter atp-binding protein
H7F27_RS01105	COG1473	amidohydrolase
H7F27_RS01110	COG2079	MmgE PrpD family protein
H7F27_RS01115	COG3192	ethanolamine utilization protein
H7F27_RS01125	COG2390	Transcriptional regulator
H7F27_RS01130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7F27_RS01135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7F27_RS01140	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7F27_RS01145	COG0833	amino acid
H7F27_RS01150	COG0010	Belongs to the arginase family
H7F27_RS01155	COG1228	amidohydrolase
H7F27_RS01160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7F27_RS01165	COG2986	histidine ammonia-lyase
H7F27_RS01180	COG3507	Belongs to the glycosyl hydrolase 43 family
H7F27_RS01190	COG0494	nUDIX hydrolase
H7F27_RS01210	COG5444	nuclease activity
H7F27_RS01230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS01230	COG2190	(PTS) system
H7F27_RS01230	COG1263	PTS System
H7F27_RS01235	COG2723	6-phospho-beta-galactosidase activity
H7F27_RS01240	COG0589	response to stress
H7F27_RS01245	COG0697	spore germination
H7F27_RS01275	COG3401	FG-GAP repeat protein
H7F27_RS01275	COG2755	lipolytic protein G-D-S-L family
H7F27_RS01280	COG0513	Belongs to the DEAD box helicase family
H7F27_RS01295	COG3711	transcriptional antiterminator
H7F27_RS01300	COG2190	(PTS) system
H7F27_RS01300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS01300	COG1263	PTS System
H7F27_RS01305	COG2723	6-phospho-beta-galactosidase activity
H7F27_RS01315	COG2851	Citrate transporter
H7F27_RS01320	COG0693	protein deglycase activity
H7F27_RS01320	COG0753	catalase activity
H7F27_RS01335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7F27_RS01340	COG0500	methyltransferase
H7F27_RS01345	COG2610	gluconate transmembrane transporter activity
H7F27_RS01350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7F27_RS01355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7F27_RS01360	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS01365	COG3829	transcription factor binding
H7F27_RS01365	COG3290	protein histidine kinase activity
H7F27_RS01370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7F27_RS01375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7F27_RS01380	COG4894	glucomannan catabolic process
H7F27_RS01390	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7F27_RS01400	COG0583	DNA-binding transcription factor activity
H7F27_RS01405	COG1881	PFAM PEBP family protein
H7F27_RS01410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7F27_RS01420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F27_RS01425	COG2508	Transcriptional regulator
H7F27_RS01430	COG3842	ATPase activity
H7F27_RS01440	COG0726	polysaccharide deacetylase
H7F27_RS01450	COG0501	Belongs to the peptidase M48B family
H7F27_RS01455	COG3493	citrate carrier protein
H7F27_RS01460	COG1271	oxidase subunit
H7F27_RS01465	COG1294	oxidase, subunit
H7F27_RS01470	COG4988	ABC transporter
H7F27_RS01475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7F27_RS01480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7F27_RS01485	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H7F27_RS01490	COG1595	DNA-templated transcription, initiation
H7F27_RS01510	COG1131	(ABC) transporter
H7F27_RS01515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H7F27_RS01520	COG2814	Major facilitator Superfamily
H7F27_RS01525	COG0753	catalase activity
H7F27_RS01530	COG2094	Belongs to the DNA glycosylase MPG family
H7F27_RS01540	COG3711	transcriptional antiterminator
H7F27_RS01540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F27_RS01545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F27_RS01550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F27_RS01555	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7F27_RS01560	COG1486	melibiose metabolic process
H7F27_RS01565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F27_RS01570	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H7F27_RS01575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H7F27_RS01580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F27_RS01585	COG1696	Membrane protein involved in D-alanine export
H7F27_RS01590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS01600	COG1575	Belongs to the MenA family. Type 1 subfamily
H7F27_RS01605	COG2357	RelA SpoT domain protein
H7F27_RS01610	COG2234	aminopeptidase activity
H7F27_RS01615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7F27_RS01620	COG1846	Transcriptional regulator
H7F27_RS01625	COG5522	Integral membrane protein (intg_mem_TP0381)
H7F27_RS01630	COG1442	glycosyl transferase family 8
H7F27_RS01635	COG3711	transcriptional antiterminator
H7F27_RS01640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS01640	COG1263	PTS System
H7F27_RS01645	COG1404	Belongs to the peptidase S8 family
H7F27_RS01650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F27_RS01660	COG0346	lactoylglutathione lyase activity
H7F27_RS01665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7F27_RS01670	COG4895	conserved protein (DUF2196)
H7F27_RS01675	COG2814	Major facilitator Superfamily
H7F27_RS01680	COG1346	cytolysis
H7F27_RS01685	COG1380	Effector of murein hydrolase LrgA
H7F27_RS01690	COG0583	DNA-binding transcription factor activity
H7F27_RS01695	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H7F27_RS01700	COG0352	thiamine-phosphate diphosphorylase activity
H7F27_RS01705	COG0672	)-iron permease
H7F27_RS01710	COG2822	iron ion transport
H7F27_RS01715	COG2837	iron assimilation
H7F27_RS01720	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7F27_RS01725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F27_RS01730	COG3162	membrane
H7F27_RS01740	COG1309	transcriptional regulator
H7F27_RS01745	COG2246	polysaccharide biosynthetic process
H7F27_RS01750	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7F27_RS01755	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H7F27_RS01760	COG2261	transglycosylase associated protein
H7F27_RS01765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7F27_RS01770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7F27_RS01790	COG0772	Belongs to the SEDS family
H7F27_RS01795	COG0778	Nitroreductase
H7F27_RS01800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F27_RS01805	COG1404	Belongs to the peptidase S8 family
H7F27_RS01815	COG3711	transcriptional antiterminator
H7F27_RS01820	COG2116	formate transmembrane transporter activity
H7F27_RS01825	COG1263	PTS System
H7F27_RS01825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS01830	COG1621	beta-fructofuranosidase activity
H7F27_RS01840	COG0351	phosphomethylpyrimidine kinase
H7F27_RS01845	COG1695	Transcriptional regulator
H7F27_RS01860	COG1216	Glycosyl transferase, family 2
H7F27_RS01865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7F27_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS01880	COG2233	PERMEase
H7F27_RS01885	COG2363	Small membrane protein
H7F27_RS01900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F27_RS01905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F27_RS01910	COG0456	acetyltransferase
H7F27_RS01915	COG2089	acid synthase
H7F27_RS01920	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
H7F27_RS01925	COG3980	spore coat polysaccharide biosynthesis protein
H7F27_RS01930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7F27_RS01935	COG1088	dTDP-glucose 4,6-dehydratase activity
H7F27_RS01940	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7F27_RS01945	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H7F27_RS01955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F27_RS01960	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS01965	COG4187	Peptidase family M20/M25/M40
H7F27_RS01970	COG0833	amino acid
H7F27_RS01980	COG2814	Major facilitator Superfamily
H7F27_RS01985	COG0077	Prephenate dehydratase
H7F27_RS01990	COG1917	Cupin 2, conserved barrel domain protein
H7F27_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS02000	COG0151	Belongs to the GarS family
H7F27_RS02005	COG2814	Major facilitator Superfamily
H7F27_RS02010	COG0436	Aminotransferase
H7F27_RS02015	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS02020	COG3253	May function as heme-dependent peroxidase
H7F27_RS02025	COG0280	phosphate acetyltransferase
H7F27_RS02030	COG0583	DNA-binding transcription factor activity
H7F27_RS02035	COG0095	Lipoate-protein ligase
H7F27_RS02040	COG0697	spore germination
H7F27_RS02050	COG4844	belongs to the
H7F27_RS02055	COG1078	dGTPase activity
H7F27_RS02060	COG3465	dGTPase activity
H7F27_RS02065	COG1959	2 iron, 2 sulfur cluster binding
H7F27_RS02070	COG0477	Major facilitator Superfamily
H7F27_RS02075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7F27_RS02080	COG1846	Transcriptional regulator
H7F27_RS02085	COG1942	4-Oxalocrotonate Tautomerase
H7F27_RS02090	COG1994	Peptidase M50
H7F27_RS02105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F27_RS02110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7F27_RS02115	COG0010	Belongs to the arginase family
H7F27_RS02130	COG0457	Tetratricopeptide repeat
H7F27_RS02135	COG3391	amine dehydrogenase activity
H7F27_RS02155	COG0612	Peptidase, M16
H7F27_RS02165	COG1131	(ABC) transporter
H7F27_RS02175	COG0535	radical SAM domain protein
H7F27_RS02185	COG4506	Protein conserved in bacteria
H7F27_RS02195	COG2223	nitrite transmembrane transporter activity
H7F27_RS02200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7F27_RS02210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7F27_RS02215	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H7F27_RS02220	COG1140	nitrate reductase beta subunit
H7F27_RS02225	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H7F27_RS02230	COG2181	nitrate reductase activity
H7F27_RS02240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F27_RS02250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7F27_RS02260	COG4294	response to UV
H7F27_RS02265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F27_RS02270	COG2181	nitrate reductase activity
H7F27_RS02270	COG0247	lactate metabolic process
H7F27_RS02275	COG1960	acyl-CoA dehydrogenase activity
H7F27_RS02280	COG3343	RNA polymerase activity
H7F27_RS02285	COG0504	CTP synthase activity
H7F27_RS02290	COG4821	SIS domain
H7F27_RS02295	COG2204	response regulator
H7F27_RS02300	COG0191	fructose-bisphosphate aldolase activity
H7F27_RS02305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7F27_RS02310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7F27_RS02315	COG1494	fructose-1,6-bisphosphatase
H7F27_RS02325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H7F27_RS02335	COG1435	thymidine kinase activity
H7F27_RS02340	COG0281	malic enzyme
H7F27_RS02345	COG0679	Auxin Efflux Carrier
H7F27_RS02350	COG0789	Transcriptional regulator
H7F27_RS02355	COG0346	lactoylglutathione lyase activity
H7F27_RS02360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7F27_RS02365	COG2890	protein-(glutamine-N5) methyltransferase activity
H7F27_RS02385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7F27_RS02390	COG0009	L-threonylcarbamoyladenylate synthase
H7F27_RS02395	COG1971	Probably functions as a manganese efflux pump
H7F27_RS02405	COG0698	ribose 5-phosphate isomerase
H7F27_RS02410	COG4475	Protein of unknown function (DUF436)
H7F27_RS02415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7F27_RS02420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7F27_RS02430	COG0356	it plays a direct role in the translocation of protons across the membrane
H7F27_RS02440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7F27_RS02445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7F27_RS02455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7F27_RS02460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7F27_RS02465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7F27_RS02475	COG4836	Membrane
H7F27_RS02485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7F27_RS02490	COG2385	sporulation resulting in formation of a cellular spore
H7F27_RS02495	COG2304	oxidoreductase activity
H7F27_RS02500	COG2304	oxidoreductase activity
H7F27_RS02510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7F27_RS02515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7F27_RS02520	COG0457	Tetratricopeptide repeat
H7F27_RS02525	COG1994	Peptidase M50
H7F27_RS02530	COG3237	CsbD-like
H7F27_RS02560	COG0831	urea catabolic process
H7F27_RS02565	COG0832	Belongs to the urease beta subunit family
H7F27_RS02570	COG0804	urea catabolic process
H7F27_RS02575	COG1959	2 iron, 2 sulfur cluster binding
H7F27_RS02580	COG2910	NAD(P)H-binding
H7F27_RS02590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F27_RS02605	COG1247	-acetyltransferase
H7F27_RS02610	COG0739	heme binding
H7F27_RS02620	COG0671	phosphoesterase, PA-phosphatase related
H7F27_RS02625	COG0347	Belongs to the P(II) protein family
H7F27_RS02630	COG0004	ammonium transporteR
H7F27_RS02640	COG1335	isochorismatase
H7F27_RS02645	COG0477	Major facilitator Superfamily
H7F27_RS02650	COG1953	Uracil, thiamine, allantoin
H7F27_RS02655	COG3420	alginic acid biosynthetic process
H7F27_RS02660	COG2814	Major facilitator Superfamily
H7F27_RS02665	COG1846	Transcriptional regulator
H7F27_RS02675	COG1609	Transcriptional regulator
H7F27_RS02680	COG1077	Cell shape determining protein MreB Mrl
H7F27_RS02685	COG4786	Flagellar basal body rod
H7F27_RS02690	COG4786	Flagellar basal body rod
H7F27_RS02695	COG0457	Tetratricopeptide repeat
H7F27_RS02700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7F27_RS02705	COG1970	mechanosensitive ion channel activity
H7F27_RS02710	COG0745	RESPONSE REGULATOR receiver
H7F27_RS02710	COG2972	Histidine kinase
H7F27_RS02715	COG3279	Response regulator of the LytR AlgR family
H7F27_RS02725	COG3764	Sortase (surface protein transpeptidase)
H7F27_RS02730	COG2602	Beta-lactamase
H7F27_RS02745	COG0629	single-stranded DNA binding
H7F27_RS02750	COG1349	DNA-binding transcription factor activity
H7F27_RS02755	COG0561	phosphatase activity
H7F27_RS02760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7F27_RS02765	COG4715	Zinc finger, swim domain protein
H7F27_RS02775	COG3944	biosynthesis protein
H7F27_RS02780	COG0489	protein tyrosine kinase activity
H7F27_RS02785	COG4464	protein tyrosine phosphatase activity
H7F27_RS02790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7F27_RS02815	COG5444	nuclease activity
H7F27_RS02850	COG0583	DNA-binding transcription factor activity
H7F27_RS02855	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7F27_RS02860	COG2059	Chromate
H7F27_RS02865	COG2059	Chromate
H7F27_RS02870	COG1522	sequence-specific DNA binding
H7F27_RS02875	COG0405	Gamma-glutamyltransferase
H7F27_RS02885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7F27_RS02900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F27_RS02905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7F27_RS02915	COG5337	Spore coat protein CotH
H7F27_RS02930	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H7F27_RS02935	COG0583	DNA-binding transcription factor activity
H7F27_RS02940	COG0028	Belongs to the TPP enzyme family
H7F27_RS02945	COG3527	Alpha-acetolactate decarboxylase
H7F27_RS02950	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7F27_RS02960	COG3103	Sh3 type 3 domain protein
H7F27_RS02965	COG1879	ABC-type sugar transport system periplasmic component
H7F27_RS02970	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7F27_RS02975	COG1129	ABC transporter
H7F27_RS02980	COG1869	D-ribose catabolic process
H7F27_RS02985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F27_RS02990	COG1609	Transcriptional regulator
H7F27_RS02995	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7F27_RS03005	COG2843	Capsule synthesis protein
H7F27_RS03020	COG0791	NLP P60 protein
H7F27_RS03025	COG0561	phosphatase activity
H7F27_RS03030	COG1316	TRANSCRIPTIONal
H7F27_RS03035	COG2814	Major facilitator Superfamily
H7F27_RS03045	COG0814	amino acid
H7F27_RS03050	COG0697	spore germination
H7F27_RS03055	COG1482	cell wall glycoprotein biosynthetic process
H7F27_RS03060	COG4193	domain, Protein
H7F27_RS03070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F27_RS03075	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H7F27_RS03080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7F27_RS03085	COG0438	transferase activity, transferring glycosyl groups
H7F27_RS03090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F27_RS03095	COG1682	transport, permease protein
H7F27_RS03100	COG1134	teichoic acid transport
H7F27_RS03115	COG0463	Glycosyl transferase, family 2
H7F27_RS03120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F27_RS03120	COG1215	transferase activity, transferring glycosyl groups
H7F27_RS03140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7F27_RS03145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7F27_RS03150	COG1316	TRANSCRIPTIONal
H7F27_RS03160	COG2385	sporulation resulting in formation of a cellular spore
H7F27_RS03160	COG2247	cell wall binding repeat
H7F27_RS03165	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F27_RS03165	COG2247	cell wall binding repeat
H7F27_RS03180	COG2244	polysaccharide biosynthetic process
H7F27_RS03185	COG0438	transferase activity, transferring glycosyl groups
H7F27_RS03185	COG0297	glycogen (starch) synthase activity
H7F27_RS03190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7F27_RS03195	COG3307	-O-antigen
H7F27_RS03200	COG3206	protein involved in exopolysaccharide biosynthesis
H7F27_RS03205	COG1215	transferase activity, transferring glycosyl groups
H7F27_RS03210	COG0438	transferase activity, transferring glycosyl groups
H7F27_RS03215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7F27_RS03220	COG1316	TRANSCRIPTIONal
H7F27_RS03225	COG1739	Uncharacterized protein family UPF0029
H7F27_RS03230	COG4585	Histidine kinase
H7F27_RS03235	COG2197	response regulator
H7F27_RS03240	COG1307	EDD domain protein, DegV family
H7F27_RS03245	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H7F27_RS03255	COG1040	competence protein
H7F27_RS03265	COG2747	anti-sigma28 factor FlgM
H7F27_RS03270	COG3418	PFAM FlgN family protein
H7F27_RS03275	COG4786	Flagellar basal body rod
H7F27_RS03275	COG1256	bacterial-type flagellum assembly
H7F27_RS03280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F27_RS03290	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H7F27_RS03295	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7F27_RS03300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F27_RS03305	COG1334	flagellar protein FlaG
H7F27_RS03310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7F27_RS03315	COG1516	flagellar protein fliS
H7F27_RS03330	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7F27_RS03335	COG0653	protein targeting
H7F27_RS03345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F27_RS03350	COG2010	Cytochrome c
H7F27_RS03355	COG2884	Cell division ATP-binding protein ftsE
H7F27_RS03360	COG2177	Part of the ABC transporter FtsEX involved in
H7F27_RS03365	COG0793	Belongs to the peptidase S41A family
H7F27_RS03365	COG3409	Peptidoglycan-binding domain 1 protein
H7F27_RS03375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F27_RS03380	COG2814	Major facilitator Superfamily
H7F27_RS03385	COG1309	transcriptional regulator
H7F27_RS03390	COG3848	Pyruvate phosphate dikinase
H7F27_RS03390	COG0574	Belongs to the PEP-utilizing enzyme family
H7F27_RS03395	COG4897	Protein conserved in bacteria
H7F27_RS03405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7F27_RS03420	COG3595	metallopeptidase activity
H7F27_RS03425	COG1983	PspC domain protein
H7F27_RS03430	COG1950	PFAM Membrane protein of
H7F27_RS03435	COG2814	Major facilitator Superfamily
H7F27_RS03440	COG1846	Transcriptional regulator
H7F27_RS03450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H7F27_RS03455	COG2188	Transcriptional regulator
H7F27_RS03460	COG0363	glucosamine-6-phosphate deaminase activity
H7F27_RS03465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7F27_RS03470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H7F27_RS03475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7F27_RS03480	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H7F27_RS03485	COG0546	phosphoglycolate phosphatase activity
H7F27_RS03490	COG0110	maltose O-acetyltransferase activity
H7F27_RS03495	COG5297	Belongs to the glycosyl hydrolase family 6
H7F27_RS03500	COG4990	cell redox homeostasis
H7F27_RS03505	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H7F27_RS03510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7F27_RS03515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7F27_RS03520	COG0131	Imidazoleglycerol-phosphate dehydratase
H7F27_RS03525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7F27_RS03530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7F27_RS03535	COG0107	imidazoleglycerol-phosphate synthase activity
H7F27_RS03540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7F27_RS03540	COG0140	phosphoribosyl-ATP diphosphatase activity
H7F27_RS03560	COG1132	(ABC) transporter
H7F27_RS03565	COG0457	Tetratricopeptide repeat
H7F27_RS03570	COG0791	NLP P60 protein
H7F27_RS03570	COG3883	PFAM NLP P60 protein
H7F27_RS03575	COG0492	ferredoxin-NADP+ reductase activity
H7F27_RS03580	COG1051	belongs to the nudix hydrolase family
H7F27_RS03585	COG1660	Displays ATPase and GTPase activities
H7F27_RS03590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H7F27_RS03595	COG1481	regulation of sporulation
H7F27_RS03600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F27_RS03605	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H7F27_RS03615	COG0745	RESPONSE REGULATOR receiver
H7F27_RS03620	COG5002	protein histidine kinase activity
H7F27_RS03625	COG1136	(ABC) transporter
H7F27_RS03630	COG0577	efflux transmembrane transporter activity
H7F27_RS03635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F27_RS03640	COG0288	reversible hydration of carbon dioxide
H7F27_RS03645	COG0659	secondary active sulfate transmembrane transporter activity
H7F27_RS03650	COG1694	Mazg nucleotide pyrophosphohydrolase
H7F27_RS03655	COG1611	Belongs to the LOG family
H7F27_RS03670	COG0277	FAD linked oxidase domain protein
H7F27_RS03680	COG2076	Multidrug Resistance protein
H7F27_RS03685	COG2076	Multidrug Resistance protein
H7F27_RS03690	COG1309	transcriptional regulator
H7F27_RS03695	COG0531	amino acid
H7F27_RS03700	COG1621	beta-fructofuranosidase activity
H7F27_RS03705	COG1621	beta-fructofuranosidase activity
H7F27_RS03710	COG0640	Transcriptional regulator
H7F27_RS03715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H7F27_RS03720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7F27_RS03730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7F27_RS03735	COG1794	racemase activity, acting on amino acids and derivatives
H7F27_RS03745	COG3479	Phenolic acid decarboxylase
H7F27_RS03755	COG2272	Belongs to the type-B carboxylesterase lipase family
H7F27_RS03760	COG1396	sequence-specific DNA binding
H7F27_RS03765	COG3944	biosynthesis protein
H7F27_RS03770	COG0489	protein tyrosine kinase activity
H7F27_RS03775	COG1086	Polysaccharide biosynthesis protein
H7F27_RS03780	COG0438	transferase activity, transferring glycosyl groups
H7F27_RS03785	COG1215	transferase activity, transferring glycosyl groups
H7F27_RS03790	COG0438	transferase activity, transferring glycosyl groups
H7F27_RS03800	COG1216	Glycosyl transferase, family 2
H7F27_RS03805	COG5039	Polysaccharide pyruvyl transferase
H7F27_RS03810	COG1216	Glycosyl transferase, family 2
H7F27_RS03815	COG2244	polysaccharide biosynthetic process
H7F27_RS03820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7F27_RS03825	COG0110	maltose O-acetyltransferase activity
H7F27_RS03830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F27_RS03835	COG5039	Polysaccharide pyruvyl transferase
H7F27_RS03845	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7F27_RS03850	COG1620	l-lactate permease
H7F27_RS03855	COG2186	Transcriptional regulator
H7F27_RS03860	COG1609	Transcriptional regulator
H7F27_RS03865	COG2182	Extracellular solute-binding protein
H7F27_RS03870	COG1175	transmembrane transport
H7F27_RS03875	COG3833	ABC-type maltose transport systems, permease component
H7F27_RS03880	COG1874	Beta-galactosidase
H7F27_RS03885	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H7F27_RS03890	COG2208	phosphoserine phosphatase activity
H7F27_RS03895	COG0596	Alpha beta hydrolase
H7F27_RS03900	COG1131	(ABC) transporter
H7F27_RS03905	COG0842	Transport permease protein
H7F27_RS03910	COG4585	Histidine kinase
H7F27_RS03915	COG2197	response regulator
H7F27_RS03920	COG0247	lactate metabolic process
H7F27_RS03925	COG1139	Iron-sulfur cluster binding protein
H7F27_RS03930	COG1556	Lactate utilization protein
H7F27_RS03935	COG3858	chitin binding
H7F27_RS03940	COG1113	amino acid transport
H7F27_RS03945	COG0697	spore germination
H7F27_RS03950	COG0583	DNA-binding transcription factor activity
H7F27_RS03960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F27_RS03965	COG1609	Transcriptional regulator
H7F27_RS03970	COG2814	Major facilitator Superfamily
H7F27_RS03975	COG2390	Transcriptional regulator
H7F27_RS03980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7F27_RS03990	COG0126	phosphoglycerate kinase activity
H7F27_RS03995	COG0149	triose-phosphate isomerase activity
H7F27_RS04000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7F27_RS04010	COG2234	aminopeptidase activity
H7F27_RS04020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F27_RS04025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F27_RS04045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F27_RS04060	COG0456	acetyltransferase
H7F27_RS04065	COG4640	response to antibiotic
H7F27_RS04070	COG3064	Membrane
H7F27_RS04080	COG1510	regulation of RNA biosynthetic process
H7F27_RS04085	COG0517	IMP dehydrogenase activity
H7F27_RS04085	COG1125	glycine betaine transport
H7F27_RS04090	COG1174	glycine betaine transport
H7F27_RS04095	COG1732	Glycine betaine
H7F27_RS04100	COG1174	glycine betaine transport
H7F27_RS04105	COG0640	Transcriptional regulator
H7F27_RS04110	COG5658	integral membrane protein
H7F27_RS04130	COG1510	regulation of RNA biosynthetic process
H7F27_RS04135	COG0517	IMP dehydrogenase activity
H7F27_RS04135	COG1125	glycine betaine transport
H7F27_RS04140	COG1174	glycine betaine transport
H7F27_RS04145	COG1732	Glycine betaine
H7F27_RS04150	COG1174	glycine betaine transport
H7F27_RS04155	COG0840	transmembrane signaling receptor activity
H7F27_RS04160	COG1733	regulation of RNA biosynthetic process
H7F27_RS04165	COG1396	sequence-specific DNA binding
H7F27_RS04170	COG1396	sequence-specific DNA binding
H7F27_RS04175	COG1476	TRANSCRIPTIONal
H7F27_RS04180	COG0596	Alpha beta hydrolase
H7F27_RS04185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7F27_RS04190	COG1647	Serine aminopeptidase, S33
H7F27_RS04195	COG0557	exoribonuclease II activity
H7F27_RS04200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7F27_RS04210	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS04215	COG1309	transcriptional regulator
H7F27_RS04220	COG2076	Multidrug Resistance protein
H7F27_RS04230	COG0697	spore germination
H7F27_RS04235	COG1802	Transcriptional regulator
H7F27_RS04240	COG1289	transmembrane transporter activity
H7F27_RS04245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7F27_RS04250	COG0673	inositol 2-dehydrogenase activity
H7F27_RS04255	COG1937	Protein conserved in bacteria
H7F27_RS04260	COG2608	mercury ion transmembrane transporter activity
H7F27_RS04265	COG2217	Heavy metal translocating P-type atpase
H7F27_RS04270	COG2217	Heavy metal translocating P-type atpase
H7F27_RS04275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7F27_RS04280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7F27_RS04290	COG2860	membrane
H7F27_RS04300	COG3973	AAA domain
H7F27_RS04305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7F27_RS04310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F27_RS04315	COG0025	NhaP-type Na H and K H
H7F27_RS04330	COG0656	L-ascorbic acid biosynthetic process
H7F27_RS04335	COG4149	molybdate abc transporter
H7F27_RS04340	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7F27_RS04345	COG1910	domain protein
H7F27_RS04350	COG1368	sulfuric ester hydrolase activity
H7F27_RS04355	COG1988	membrane-bound metal-dependent
H7F27_RS04365	COG0531	amino acid
H7F27_RS04370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F27_RS04375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS04380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS04385	COG1120	ATPase activity
H7F27_RS04390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F27_RS04395	COG1136	(ABC) transporter
H7F27_RS04400	COG0577	efflux transmembrane transporter activity
H7F27_RS04410	COG2140	Oxalate decarboxylase
H7F27_RS04420	COG1191	sigma factor activity
H7F27_RS04430	COG0745	RESPONSE REGULATOR receiver
H7F27_RS04435	COG2205	protein histidine kinase activity
H7F27_RS04440	COG3386	PFAM SMP-30 Gluconolaconase
H7F27_RS04445	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS04450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F27_RS04455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS04460	COG1120	ATPase activity
H7F27_RS04465	COG2096	Adenosyltransferase
H7F27_RS04470	COG2814	Major facilitator Superfamily
H7F27_RS04475	COG4758	membrane
H7F27_RS04480	COG1842	Phage shock protein A
H7F27_RS04485	COG3595	metallopeptidase activity
H7F27_RS04490	COG4758	membrane
H7F27_RS04495	COG4585	Histidine kinase
H7F27_RS04500	COG2197	response regulator
H7F27_RS04510	COG0814	amino acid
H7F27_RS04515	COG0697	spore germination
H7F27_RS04525	COG0114	fumarate hydratase activity
H7F27_RS04530	COG1309	transcriptional regulator
H7F27_RS04540	COG2770	Histidine kinase
H7F27_RS04540	COG2205	protein histidine kinase activity
H7F27_RS04545	COG0745	RESPONSE REGULATOR receiver
H7F27_RS04550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F27_RS04555	COG0783	Belongs to the Dps family
H7F27_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS04575	COG1120	ATPase activity
H7F27_RS04585	COG0583	DNA-binding transcription factor activity
H7F27_RS04590	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS04595	COG1942	4-Oxalocrotonate Tautomerase
H7F27_RS04600	COG0477	Major facilitator Superfamily
H7F27_RS04605	COG1846	Transcriptional regulator
H7F27_RS04610	COG5577	PFAM Coat F domain
H7F27_RS04620	COG0506	proline dehydrogenase activity
H7F27_RS04630	COG1024	Enoyl-CoA hydratase
H7F27_RS04630	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F27_RS04635	COG0183	Belongs to the thiolase family
H7F27_RS04640	COG1960	acyl-CoA dehydrogenase activity
H7F27_RS04645	COG1393	Belongs to the ArsC family
H7F27_RS04650	COG0509	glycine decarboxylation via glycine cleavage system
H7F27_RS04660	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H7F27_RS04665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F27_RS04675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7F27_RS04680	COG2011	ABC-type metal ion transport system permease component
H7F27_RS04685	COG1464	Belongs to the NlpA lipoprotein family
H7F27_RS04690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7F27_RS04700	COG0396	ATPase activity
H7F27_RS04705	COG0719	Fe-S assembly protein
H7F27_RS04710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7F27_RS04715	COG0822	iron-sulfur transferase activity
H7F27_RS04720	COG0719	Fe-S assembly protein
H7F27_RS04735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7F27_RS04740	COG0322	excinuclease ABC activity
H7F27_RS04745	COG2222	sugar isomerase
H7F27_RS04750	COG1653	transport
H7F27_RS04755	COG1175	transmembrane transport
H7F27_RS04760	COG0395	ABC-type sugar transport system, permease component
H7F27_RS04765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F27_RS04770	COG2188	Transcriptional regulator
H7F27_RS04775	COG3842	ATPase activity
H7F27_RS04780	COG2356	endonuclease I
H7F27_RS04790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7F27_RS04795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7F27_RS04800	COG2068	MobA-Related Protein
H7F27_RS04805	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7F27_RS04810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7F27_RS04815	COG2080	2 iron, 2 sulfur cluster binding
H7F27_RS04825	COG2351	hydroxyisourate hydrolase activity
H7F27_RS04830	COG3648	Uricase
H7F27_RS04830	COG3195	allantoin biosynthetic process
H7F27_RS04835	COG2233	PERMEase
H7F27_RS04840	COG2233	PERMEase
H7F27_RS04845	COG2508	Transcriptional regulator
H7F27_RS04850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7F27_RS04860	COG1801	Protein of unknown function DUF72
H7F27_RS04865	COG0730	response to heat
H7F27_RS04870	COG0737	Belongs to the 5'-nucleotidase family
H7F27_RS04875	COG3377	Domain of unknown function (DUF1805)
H7F27_RS04885	COG0739	heme binding
H7F27_RS04900	COG4470	Protein conserved in bacteria
H7F27_RS04905	COG2445	Protein of unknown function DUF86
H7F27_RS04910	COG0647	UMP catabolic process
H7F27_RS04915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7F27_RS04920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7F27_RS04925	COG0460	homoserine dehydrogenase
H7F27_RS04930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7F27_RS04935	COG0083	homoserine kinase activity
H7F27_RS04940	COG0823	Involved in the tonB-independent uptake of proteins
H7F27_RS04940	COG4946	Tricorn protease homolog
H7F27_RS04940	COG1506	peptidase
H7F27_RS04945	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7F27_RS04950	COG4837	Protein of unknown function (DUF1462)
H7F27_RS04955	COG1252	NADH dehydrogenase
H7F27_RS04960	COG4844	belongs to the
H7F27_RS04965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7F27_RS04970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7F27_RS04975	COG0316	Belongs to the HesB IscA family
H7F27_RS04980	COG0516	GMP reductase activity
H7F27_RS04990	COG0492	ferredoxin-NADP+ reductase activity
H7F27_RS04995	COG1252	NADH dehydrogenase
H7F27_RS05010	COG3584	3D domain protein
H7F27_RS05015	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H7F27_RS05020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7F27_RS05025	COG2056	Na+-H+ antiporter family
H7F27_RS05030	COG1268	BioY protein
H7F27_RS05035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7F27_RS05040	COG2819	hydrolase of the alpha beta superfamily
H7F27_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS05050	COG1169	isochorismate synthase
H7F27_RS05055	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7F27_RS05060	COG3433	isochorismatase activity
H7F27_RS05060	COG1535	isochorismatase
H7F27_RS05065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS05070	COG3251	PFAM MbtH domain protein
H7F27_RS05075	COG5634	Uncharacterized conserved protein (DUF2278)
H7F27_RS05080	COG0686	Belongs to the AlaDH PNT family
H7F27_RS05085	COG2508	Transcriptional regulator
H7F27_RS05085	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H7F27_RS05090	COG4842	Belongs to the WXG100 family
H7F27_RS05095	COG5417	Belongs to the EsaB family
H7F27_RS05100	COG4499	WXG100 protein secretion system (Wss), protein YukC
H7F27_RS05105	COG1674	ftsk spoiiie
H7F27_RS05105	COG0433	COG0433 Predicted ATPase
H7F27_RS05110	COG1511	domain protein
H7F27_RS05120	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS05125	COG1418	mRNA catabolic process
H7F27_RS05135	COG0628	permease
H7F27_RS05150	COG5506	Protein of unknown function (DUF1694)
H7F27_RS05160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7F27_RS05165	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7F27_RS05180	COG0142	geranyltranstransferase activity
H7F27_RS05190	COG4585	Histidine kinase
H7F27_RS05195	COG2197	response regulator
H7F27_RS05200	COG2050	protein possibly involved in aromatic compounds catabolism
H7F27_RS05205	COG1320	monovalent cation:proton antiporter activity
H7F27_RS05210	COG2212	antiporter activity
H7F27_RS05215	COG1863	multisubunit Na H antiporter MnhE subunit
H7F27_RS05220	COG0651	ATP synthesis coupled electron transport
H7F27_RS05225	COG1006	Multisubunit Na H antiporter MnhC subunit
H7F27_RS05230	COG2111	Na H antiporter
H7F27_RS05235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7F27_RS05235	COG2111	Na H antiporter
H7F27_RS05245	COG3493	citrate carrier protein
H7F27_RS05250	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7F27_RS05255	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7F27_RS05260	COG3845	ABC transporter
H7F27_RS05265	COG1744	ABC transporter substrate-binding protein PnrA-like
H7F27_RS05270	COG4565	transcriptional regulatory protein
H7F27_RS05275	COG3290	protein histidine kinase activity
H7F27_RS05285	COG3011	Protein conserved in bacteria
H7F27_RS05290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F27_RS05295	COG2814	Major facilitator Superfamily
H7F27_RS05300	COG5018	Exonuclease
H7F27_RS05310	COG2205	protein histidine kinase activity
H7F27_RS05315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7F27_RS05325	COG2267	carboxylic ester hydrolase activity
H7F27_RS05330	COG1522	sequence-specific DNA binding
H7F27_RS05335	COG0436	Aminotransferase
H7F27_RS05340	COG1098	S1 RNA binding domain
H7F27_RS05345	COG2155	Conserved Protein
H7F27_RS05350	COG1979	alcohol dehydrogenase
H7F27_RS05355	COG1979	alcohol dehydrogenase
H7F27_RS05360	COG0166	Belongs to the GPI family
H7F27_RS05375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7F27_RS05390	COG2738	Putative neutral zinc metallopeptidase
H7F27_RS05395	COG1253	flavin adenine dinucleotide binding
H7F27_RS05400	COG0366	Alpha amylase catalytic
H7F27_RS05405	COG0432	Pfam Uncharacterised protein family UPF0047
H7F27_RS05410	COG2070	2-Nitropropane dioxygenase
H7F27_RS05425	COG0840	transmembrane signaling receptor activity
H7F27_RS05430	COG0840	transmembrane signaling receptor activity
H7F27_RS05435	COG0840	transmembrane signaling receptor activity
H7F27_RS05440	COG0840	transmembrane signaling receptor activity
H7F27_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS05445	COG3347	Dehydrogenase
H7F27_RS05450	COG1349	DNA-binding transcription factor activity
H7F27_RS05455	COG1070	Carbohydrate kinase
H7F27_RS05460	COG3254	rhamnose metabolic process
H7F27_RS05465	COG4806	L-rhamnose isomerase
H7F27_RS05470	COG0673	inositol 2-dehydrogenase activity
H7F27_RS05475	COG0628	permease
H7F27_RS05480	COG1968	undecaprenyl-diphosphatase activity
H7F27_RS05490	COG5553	Cysteine dioxygenase type I
H7F27_RS05495	COG0477	Major facilitator Superfamily
H7F27_RS05500	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7F27_RS05505	COG4682	membrane
H7F27_RS05510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7F27_RS05515	COG0569	domain protein
H7F27_RS05525	COG1510	regulation of RNA biosynthetic process
H7F27_RS05530	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS05535	COG1454	alcohol dehydrogenase
H7F27_RS05545	COG2318	DinB family
H7F27_RS05550	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7F27_RS05555	COG2268	Band 7 protein
H7F27_RS05560	COG1247	-acetyltransferase
H7F27_RS05565	COG3859	Proton-coupled thiamine transporter YuaJ
H7F27_RS05690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7F27_RS05695	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7F27_RS05700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7F27_RS05705	COG0297	glycogen (starch) synthase activity
H7F27_RS05710	COG0058	SHG alpha-glucan phosphorylase activity
H7F27_RS05715	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H7F27_RS05720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7F27_RS05725	COG1169	isochorismate synthase
H7F27_RS05730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7F27_RS05735	COG0596	Alpha beta hydrolase
H7F27_RS05740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7F27_RS05745	COG0318	PFAM AMP-dependent synthetase and ligase
H7F27_RS05750	COG4948	Mandelate Racemase Muconate Lactonizing
H7F27_RS05755	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7F27_RS05760	COG1121	(ABC) transporter
H7F27_RS05765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7F27_RS05765	COG1321	iron dependent repressor
H7F27_RS05770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7F27_RS05780	COG1294	oxidase, subunit
H7F27_RS05785	COG1271	oxidase subunit
H7F27_RS05790	COG0254	rRNA binding
H7F27_RS05795	COG0288	reversible hydration of carbon dioxide
H7F27_RS05800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7F27_RS05805	COG1854	S-ribosylhomocysteine lyase activity
H7F27_RS05820	COG0783	Belongs to the Dps family
H7F27_RS05825	COG4824	toxin secretion phage lysis holin
H7F27_RS05830	COG0494	nUDIX hydrolase
H7F27_RS05835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7F27_RS05840	COG1116	anion transmembrane transporter activity
H7F27_RS05845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7F27_RS05850	COG1506	peptidase
H7F27_RS05860	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7F27_RS05865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7F27_RS05870	COG0367	asparagine synthase
H7F27_RS05875	COG1113	amino acid transport
H7F27_RS05880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7F27_RS05885	COG2267	carboxylic ester hydrolase activity
H7F27_RS05895	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H7F27_RS05900	COG1242	4 iron, 4 sulfur cluster binding
H7F27_RS05915	COG1725	Transcriptional regulator
H7F27_RS05920	COG1131	(ABC) transporter
H7F27_RS05935	COG1136	(ABC) transporter
H7F27_RS05940	COG0577	efflux transmembrane transporter activity
H7F27_RS05945	COG0745	RESPONSE REGULATOR receiver
H7F27_RS05950	COG2205	protein histidine kinase activity
H7F27_RS05955	COG1136	(ABC) transporter
H7F27_RS05960	COG0577	efflux transmembrane transporter activity
H7F27_RS05965	COG2433	Pfam Transposase IS66
H7F27_RS05970	COG2814	Major facilitator Superfamily
H7F27_RS05975	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F27_RS05975	COG2202	Pas domain
H7F27_RS05985	COG0495	leucyl-tRNA aminoacylation
H7F27_RS05990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F27_RS05995	COG1486	melibiose metabolic process
H7F27_RS06000	COG0395	ABC-type sugar transport system, permease component
H7F27_RS06005	COG1175	transmembrane transport
H7F27_RS06010	COG1653	transport
H7F27_RS06015	COG1609	Transcriptional regulator
H7F27_RS06020	COG1073	alpha beta
H7F27_RS06030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7F27_RS06035	COG0156	8-amino-7-oxononanoate synthase activity
H7F27_RS06045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7F27_RS06050	COG2124	cytochrome p450
H7F27_RS06055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F27_RS06060	COG0395	ABC-type sugar transport system, permease component
H7F27_RS06065	COG1653	transport
H7F27_RS06070	COG2207	Transcriptional regulator
H7F27_RS06075	COG4209	transmembrane transport
H7F27_RS06080	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H7F27_RS06085	COG1653	transport
H7F27_RS06090	COG0673	inositol 2-dehydrogenase activity
H7F27_RS06095	COG5578	integral membrane protein
H7F27_RS06105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7F27_RS06110	COG2081	HI0933 family
H7F27_RS06115	COG2244	polysaccharide biosynthetic process
H7F27_RS06120	COG1187	pseudouridine synthase activity
H7F27_RS06125	COG1349	DNA-binding transcription factor activity
H7F27_RS06130	COG1131	(ABC) transporter
H7F27_RS06135	COG4473	ABC transporter
H7F27_RS06140	COG2252	PERMEase
H7F27_RS06145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7F27_RS06150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F27_RS06155	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H7F27_RS06165	COG1597	lipid kinase activity
H7F27_RS06170	COG1523	belongs to the glycosyl hydrolase 13 family
H7F27_RS06175	COG0510	thiamine kinase activity
H7F27_RS06185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7F27_RS06190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F27_RS06195	COG0281	malic enzyme
H7F27_RS06200	COG5584	Small secreted protein
H7F27_RS06205	COG1363	Peptidase, m42
H7F27_RS06220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F27_RS06225	COG4848	Belongs to the UPF0354 family
H7F27_RS06230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F27_RS06235	COG1674	ftsk spoiiie
H7F27_RS06240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7F27_RS06245	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H7F27_RS06250	COG4980	gas vesicle protein
H7F27_RS06255	COG3118	belongs to the thioredoxin family
H7F27_RS06260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H7F27_RS06260	COG1605	Chorismate mutase
H7F27_RS06265	COG1609	Transcriptional regulator
H7F27_RS06270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7F27_RS06275	COG1360	Flagellar Motor Protein
H7F27_RS06280	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7F27_RS06290	COG0454	-acetyltransferase
H7F27_RS06295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7F27_RS06300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7F27_RS06310	COG2203	Gaf domain
H7F27_RS06310	COG2199	diguanylate cyclase activity
H7F27_RS06315	COG1956	GAF domain-containing protein
H7F27_RS06320	COG1309	transcriptional regulator
H7F27_RS06325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7F27_RS06330	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H7F27_RS06335	COG1114	Component of the transport system for branched-chain amino acids
H7F27_RS06340	COG1104	cysteine desulfurase activity
H7F27_RS06345	COG0301	tRNA thio-modification
H7F27_RS06355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7F27_RS06360	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H7F27_RS06365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7F27_RS06370	COG0616	signal peptide processing
H7F27_RS06375	COG1714	RDD family
H7F27_RS06385	COG3874	Sporulation protein YtfJ
H7F27_RS06390	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H7F27_RS06395	COG0827	DNA restriction-modification system
H7F27_RS06400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7F27_RS06405	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7F27_RS06410	COG0137	argininosuccinate synthase activity
H7F27_RS06415	COG0165	Argininosuccinate lyase
H7F27_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS06425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7F27_RS06430	COG0583	DNA-binding transcription factor activity
H7F27_RS06435	COG0454	-acetyltransferase
H7F27_RS06440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F27_RS06445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F27_RS06450	COG0765	amino acid transport
H7F27_RS06455	COG0765	amino acid transport
H7F27_RS06460	COG1126	abc transporter atp-binding protein
H7F27_RS06465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F27_RS06470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7F27_RS06475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F27_RS06480	COG0196	riboflavin kinase activity
H7F27_RS06485	COG1473	amidohydrolase
H7F27_RS06490	COG0730	response to heat
H7F27_RS06495	COG4109	DRTGG domain
H7F27_RS06505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7F27_RS06525	COG0587	DNA-directed DNA polymerase activity
H7F27_RS06530	COG0281	malic enzyme
H7F27_RS06535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7F27_RS06540	COG0825	malonyl-CoA metabolic process
H7F27_RS06545	COG0205	6-phosphofructokinase activity
H7F27_RS06550	COG0469	pyruvate kinase activity
H7F27_RS06555	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7F27_RS06560	COG0628	permease
H7F27_RS06565	COG2707	UPF0756 membrane protein
H7F27_RS06570	COG0372	Belongs to the citrate synthase family
H7F27_RS06575	COG0538	isocitrate dehydrogenase activity
H7F27_RS06580	COG0039	L-malate dehydrogenase activity
H7F27_RS06585	COG0745	RESPONSE REGULATOR receiver
H7F27_RS06590	COG5002	protein histidine kinase activity
H7F27_RS06595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F27_RS06595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F27_RS06600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7F27_RS06605	COG1971	Probably functions as a manganese efflux pump
H7F27_RS06610	COG0237	dephospho-CoA kinase activity
H7F27_RS06615	COG0656	L-ascorbic acid biosynthetic process
H7F27_RS06620	COG2814	Major facilitator Superfamily
H7F27_RS06625	COG1733	regulation of RNA biosynthetic process
H7F27_RS06630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7F27_RS06635	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H7F27_RS06640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7F27_RS06645	COG3611	Membrane attachment protein
H7F27_RS06650	COG1484	DNA-dependent DNA replication
H7F27_RS06655	COG0398	Pfam SNARE associated Golgi protein
H7F27_RS06665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7F27_RS06670	COG1011	Hydrolase
H7F27_RS06675	COG3275	phosphorelay sensor kinase activity
H7F27_RS06680	COG3279	Response regulator of the LytR AlgR family
H7F27_RS06685	COG1380	Effector of murein hydrolase LrgA
H7F27_RS06690	COG1346	cytolysis
H7F27_RS06700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7F27_RS06705	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7F27_RS06710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7F27_RS06715	COG3326	Membrane
H7F27_RS06725	COG1363	Peptidase, m42
H7F27_RS06730	COG3507	Belongs to the glycosyl hydrolase 43 family
H7F27_RS06735	COG2160	L-arabinose isomerase activity
H7F27_RS06740	COG1069	ribulokinase activity
H7F27_RS06745	COG0235	Class ii aldolase
H7F27_RS06750	COG0647	UMP catabolic process
H7F27_RS06755	COG0371	Dehydrogenase
H7F27_RS06760	COG1653	transport
H7F27_RS06765	COG1175	transmembrane transport
H7F27_RS06770	COG0395	ABC-type sugar transport system, permease component
H7F27_RS06775	COG3534	alpha-L-arabinofuranosidase
H7F27_RS06780	COG1695	Transcriptional regulator
H7F27_RS06795	COG1966	Carbon starvation protein
H7F27_RS06800	COG0346	lactoylglutathione lyase activity
H7F27_RS06805	COG0247	lactate metabolic process
H7F27_RS06810	COG0277	FAD linked oxidase domain protein
H7F27_RS06835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7F27_RS06840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F27_RS06840	COG0072	phenylalanine-tRNA ligase activity
H7F27_RS06845	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7F27_RS06850	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H7F27_RS06855	COG1286	toxin biosynthetic process
H7F27_RS06860	COG1796	DNA polymerase
H7F27_RS06860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7F27_RS06865	COG1193	negative regulation of DNA recombination
H7F27_RS06870	COG3766	membrane
H7F27_RS06875	COG0318	PFAM AMP-dependent synthetase and ligase
H7F27_RS06880	COG1309	transcriptional regulator
H7F27_RS06885	COG1024	Enoyl-CoA hydratase
H7F27_RS06890	COG2086	electron transfer activity
H7F27_RS06895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7F27_RS06900	COG3534	alpha-L-arabinofuranosidase
H7F27_RS06905	COG3118	belongs to the thioredoxin family
H7F27_RS06910	COG0322	excinuclease ABC activity
H7F27_RS06920	COG0527	aspartate kinase activity
H7F27_RS06925	COG1719	4-vinyl reductase, 4VR
H7F27_RS06930	COG2009	succinate dehydrogenase
H7F27_RS06935	COG1053	succinate dehydrogenase
H7F27_RS06940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7F27_RS06945	COG0824	Thioesterase
H7F27_RS06950	COG2197	response regulator
H7F27_RS06955	COG1846	Transcriptional regulator
H7F27_RS06960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7F27_RS06965	COG5401	PFAM Sporulation and spore germination
H7F27_RS06970	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7F27_RS06975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7F27_RS06980	COG0622	Phosphoesterase
H7F27_RS06990	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
H7F27_RS07000	COG0454	-acetyltransferase
H7F27_RS07010	COG0028	Belongs to the TPP enzyme family
H7F27_RS07015	COG0440	acetolactate synthase activity
H7F27_RS07020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7F27_RS07025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7F27_RS07030	COG0473	3-isopropylmalate dehydrogenase activity
H7F27_RS07035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7F27_RS07040	COG0066	3-isopropylmalate dehydratase activity
H7F27_RS07045	COG0457	Tetratricopeptide repeat
H7F27_RS07045	COG1477	protein flavinylation
H7F27_RS07050	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7F27_RS07055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7F27_RS07060	COG1067	ATP-dependent peptidase activity
H7F27_RS07060	COG0470	DNA polymerase III
H7F27_RS07065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7F27_RS07070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7F27_RS07080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7F27_RS07085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7F27_RS07090	COG0181	hydroxymethylbilane synthase activity
H7F27_RS07095	COG1587	Uroporphyrinogen-III synthase
H7F27_RS07100	COG0113	porphobilinogen synthase activity
H7F27_RS07105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7F27_RS07110	COG1388	LysM domain
H7F27_RS07115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7F27_RS07125	COG0525	valine-tRNA ligase activity
H7F27_RS07130	COG0285	dihydrofolate synthase activity
H7F27_RS07135	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7F27_RS07145	COG0424	maF-like protein
H7F27_RS07150	COG2003	Belongs to the UPF0758 family
H7F27_RS07155	COG1077	Cell shape determining protein MreB Mrl
H7F27_RS07165	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7F27_RS07170	COG0850	regulation of cytokinetic process
H7F27_RS07175	COG2894	cell division
H7F27_RS07180	COG0739	heme binding
H7F27_RS07185	COG1994	Peptidase M50
H7F27_RS07190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7F27_RS07195	COG2868	ribosomal protein
H7F27_RS07200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7F27_RS07210	COG3290	protein histidine kinase activity
H7F27_RS07215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7F27_RS07220	COG4492	Belongs to the UPF0735 family
H7F27_RS07225	COG0077	Prephenate dehydratase
H7F27_RS07230	COG1827	regulation of RNA biosynthetic process
H7F27_RS07235	COG1104	cysteine desulfurase activity
H7F27_RS07240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7F27_RS07245	COG0157	Belongs to the NadC ModD family
H7F27_RS07250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7F27_RS07255	COG1388	LysM domain
H7F27_RS07270	COG1115	amino acid carrier protein
H7F27_RS07285	COG2112	serine threonine protein kinase
H7F27_RS07290	COG0673	inositol 2-dehydrogenase activity
H7F27_RS07295	COG2814	Major facilitator Superfamily
H7F27_RS07305	COG0632	four-way junction helicase activity
H7F27_RS07310	COG2255	four-way junction helicase activity
H7F27_RS07320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7F27_RS07325	COG0343	queuine tRNA-ribosyltransferase activity
H7F27_RS07330	COG1862	Preprotein translocase
H7F27_RS07340	COG2323	membrane
H7F27_RS07345	COG2244	polysaccharide biosynthetic process
H7F27_RS07355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7F27_RS07355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7F27_RS07360	COG0490	domain, Protein
H7F27_RS07365	COG5416	Lipopolysaccharide assembly protein A domain
H7F27_RS07370	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H7F27_RS07370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7F27_RS07375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7F27_RS07380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7F27_RS07385	COG1490	D-aminoacyl-tRNA deacylase activity
H7F27_RS07390	COG3103	Sh3 type 3 domain protein
H7F27_RS07390	COG4991	sh3 domain protein
H7F27_RS07390	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F27_RS07400	COG0124	histidyl-tRNA synthetase
H7F27_RS07405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7F27_RS07415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7F27_RS07420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7F27_RS07425	COG1959	2 iron, 2 sulfur cluster binding
H7F27_RS07435	COG0482	sulfurtransferase activity
H7F27_RS07440	COG0457	Tetratricopeptide repeat
H7F27_RS07445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7F27_RS07450	COG3881	PFAM PRC-barrel domain
H7F27_RS07465	COG0765	amino acid transport
H7F27_RS07470	COG0765	amino acid transport
H7F27_RS07475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F27_RS07480	COG1126	abc transporter atp-binding protein
H7F27_RS07485	COG0628	permease
H7F27_RS07490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7F27_RS07495	COG4472	Bacterial protein of unknown function (DUF965)
H7F27_RS07500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7F27_RS07505	COG3906	Belongs to the UPF0473 family
H7F27_RS07510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7F27_RS07515	COG4122	O-methyltransferase activity
H7F27_RS07520	COG0826	peptidase U32
H7F27_RS07525	COG0826	peptidase U32
H7F27_RS07530	COG0572	uridine kinase
H7F27_RS07535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7F27_RS07540	COG0768	penicillin binding
H7F27_RS07555	COG2226	methyltransferase
H7F27_RS07560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7F27_RS07565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F27_RS07570	COG0626	cystathionine gamma-synthase activity
H7F27_RS07580	COG2427	Protein of unknown function (DUF1641)
H7F27_RS07585	COG3383	formate dehydrogenase (NAD+) activity
H7F27_RS07590	COG5609	conserved protein (DUF2294)
H7F27_RS07595	COG2116	formate transmembrane transporter activity
H7F27_RS07610	COG2226	methyltransferase
H7F27_RS07615	COG1309	transcriptional regulator
H7F27_RS07620	COG2124	cytochrome p450
H7F27_RS07620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7F27_RS07630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7F27_RS07630	COG2755	lipolytic protein G-D-S-L family
H7F27_RS07640	COG1595	DNA-templated transcription, initiation
H7F27_RS07645	COG1378	Sugar-specific transcriptional regulator TrmB
H7F27_RS07650	COG1280	lysine exporter protein (LysE YggA)
H7F27_RS07655	COG1113	amino acid transport
H7F27_RS07660	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H7F27_RS07660	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7F27_RS07665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F27_RS07670	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS07675	COG3715	PTS system
H7F27_RS07680	COG3716	PTS system mannose fructose sorbose family IID component
H7F27_RS07685	COG1621	beta-fructofuranosidase activity
H7F27_RS07690	COG0693	protein deglycase activity
H7F27_RS07695	COG1064	alcohol dehydrogenase
H7F27_RS07700	COG0789	Transcriptional regulator
H7F27_RS07720	COG1794	racemase activity, acting on amino acids and derivatives
H7F27_RS07730	COG4991	sh3 domain protein
H7F27_RS07735	COG4991	sh3 domain protein
H7F27_RS07745	COG3443	Belongs to the bacterial solute-binding protein 9 family
H7F27_RS07755	COG4608	Belongs to the ABC transporter superfamily
H7F27_RS07760	COG0444	Belongs to the ABC transporter superfamily
H7F27_RS07765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F27_RS07770	COG0601	transmembrane transport
H7F27_RS07775	COG0747	negative chemotaxis
H7F27_RS07790	COG1725	Transcriptional regulator
H7F27_RS07815	COG2732	(Barnase) inhibitor
H7F27_RS07845	COG1733	regulation of RNA biosynthetic process
H7F27_RS07850	COG2085	NADP oxidoreductase coenzyme F420-dependent
H7F27_RS07860	COG0583	DNA-binding transcription factor activity
H7F27_RS07865	COG0114	fumarate hydratase activity
H7F27_RS07880	COG0563	adenylate kinase activity
H7F27_RS07955	COG1335	isochorismatase
H7F27_RS07990	COG0662	Cupin 2, conserved barrel domain protein
H7F27_RS07995	COG1937	Protein conserved in bacteria
H7F27_RS08000	COG2210	Belongs to the sulfur carrier protein TusA family
H7F27_RS08005	COG1054	Belongs to the UPF0176 family
H7F27_RS08010	COG0425	Belongs to the sulfur carrier protein TusA family
H7F27_RS08010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F27_RS08020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F27_RS08020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F27_RS08025	COG0425	Belongs to the sulfur carrier protein TusA family
H7F27_RS08030	COG0730	response to heat
H7F27_RS08065	COG1230	cation diffusion facilitator family transporter
H7F27_RS08070	COG2072	flavoprotein involved in K transport
H7F27_RS08075	COG0457	Tetratricopeptide repeat
H7F27_RS08080	COG2814	Major facilitator Superfamily
H7F27_RS08095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F27_RS08130	COG3209	COG3209 Rhs family protein
H7F27_RS08140	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H7F27_RS08145	COG0398	Pfam SNARE associated Golgi protein
H7F27_RS08150	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F27_RS08150	COG3409	Peptidoglycan-binding domain 1 protein
H7F27_RS08155	COG2755	lipolytic protein G-D-S-L family
H7F27_RS08165	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H7F27_RS08170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7F27_RS08175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7F27_RS08180	COG1534	Rna-binding protein
H7F27_RS08185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7F27_RS08190	COG1713	HD superfamily hydrolase involved in NAD metabolism
H7F27_RS08195	COG0799	negative regulation of ribosome biogenesis
H7F27_RS08200	COG2226	methyltransferase
H7F27_RS08205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F27_RS08210	COG1596	polysaccharide export
H7F27_RS08210	COG1555	photosystem II stabilization
H7F27_RS08215	COG2131	deaminase
H7F27_RS08235	COG1466	dna polymerase III delta subunit
H7F27_RS08245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7F27_RS08250	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F27_RS08260	COG0481	GTPase activity
H7F27_RS08265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7F27_RS08270	COG1420	regulation of RNA biosynthetic process
H7F27_RS08275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7F27_RS08285	COG0484	heat shock protein binding
H7F27_RS08290	COG2264	protein methyltransferase activity
H7F27_RS08295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7F27_RS08300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7F27_RS08305	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7F27_RS08315	COG1610	YqeY-like protein
H7F27_RS08320	COG1030	water channel activity
H7F27_RS08325	COG4864	UPF0365 protein
H7F27_RS08340	COG0561	phosphatase activity
H7F27_RS08345	COG1702	phosphate starvation-inducible protein PhoH
H7F27_RS08350	COG1480	7TM receptor with intracellular HD hydrolase
H7F27_RS08355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7F27_RS08360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7F27_RS08365	COG0295	cytidine deaminase activity
H7F27_RS08370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7F27_RS08380	COG1381	Involved in DNA repair and RecF pathway recombination
H7F27_RS08385	COG0752	glycyl-tRNA synthetase alpha subunit
H7F27_RS08390	COG0751	glycine-tRNA ligase activity
H7F27_RS08395	COG0517	IMP dehydrogenase activity
H7F27_RS08400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7F27_RS08405	COG1671	Belongs to the UPF0178 family
H7F27_RS08410	COG0358	DNA primase activity
H7F27_RS08415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7F27_RS08420	COG2010	Cytochrome c
H7F27_RS08425	COG2384	SAM-dependent methyltransferase
H7F27_RS08430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7F27_RS08435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7F27_RS08445	COG0513	Belongs to the DEAD box helicase family
H7F27_RS08450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7F27_RS08460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F27_RS08465	COG0735	belongs to the Fur family
H7F27_RS08470	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H7F27_RS08475	COG4709	membrane
H7F27_RS08480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7F27_RS08485	COG1388	LysM domain
H7F27_RS08490	COG5521	maltodextrose utilization protein MalA
H7F27_RS08495	COG2839	Protein conserved in bacteria
H7F27_RS08500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7F27_RS08505	COG0477	Major facilitator Superfamily
H7F27_RS08510	COG0768	penicillin binding
H7F27_RS08515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7F27_RS08520	COG0573	inorganic phosphate transmembrane transporter activity
H7F27_RS08525	COG0581	inorganic phosphate transmembrane transporter activity
H7F27_RS08530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7F27_RS08535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7F27_RS08540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7F27_RS08555	COG0438	transferase activity, transferring glycosyl groups
H7F27_RS08565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7F27_RS08575	COG0457	Tetratricopeptide repeat
H7F27_RS08575	COG0705	Rhomboid family
H7F27_RS08580	COG4483	Protein conserved in bacteria
H7F27_RS08585	COG1940	carbohydrate kinase activity
H7F27_RS08590	COG1368	sulfuric ester hydrolase activity
H7F27_RS08595	COG2866	Carboxypeptidase
H7F27_RS08605	COG0011	TIGRFAM Protein of
H7F27_RS08615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F27_RS08625	COG1393	Belongs to the ArsC family
H7F27_RS08635	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F27_RS08640	COG1253	flavin adenine dinucleotide binding
H7F27_RS08645	COG0598	Magnesium transport protein CorA
H7F27_RS08650	COG0517	IMP dehydrogenase activity
H7F27_RS08655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7F27_RS08660	COG1459	type II secretion system
H7F27_RS08665	COG4537	Required for transformation and DNA binding
H7F27_RS08670	COG4970	Tfp pilus assembly protein FimT
H7F27_RS08680	COG4940	Competence protein ComGF
H7F27_RS08705	COG0681	Belongs to the peptidase S26 family
H7F27_RS08715	COG1396	sequence-specific DNA binding
H7F27_RS08730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7F27_RS08735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7F27_RS08740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7F27_RS08745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7F27_RS08750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F27_RS08755	COG0095	Lipoate-protein ligase
H7F27_RS08760	COG1321	iron dependent repressor
H7F27_RS08765	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7F27_RS08775	COG3872	metal-dependent enzyme
H7F27_RS08785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7F27_RS08790	COG0006	proline dipeptidase activity
H7F27_RS08795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7F27_RS08805	COG3854	ATPases associated with a variety of cellular activities
H7F27_RS08845	COG0511	ligase activity, forming carbon-carbon bonds
H7F27_RS08850	COG0439	Biotin carboxylase
H7F27_RS08855	COG1302	Protein conserved in bacteria
H7F27_RS08860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7F27_RS08865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7F27_RS08870	COG1570	exodeoxyribonuclease VII activity
H7F27_RS08875	COG1722	exodeoxyribonuclease VII activity
H7F27_RS08880	COG0142	geranyltranstransferase activity
H7F27_RS08885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7F27_RS08890	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H7F27_RS08895	COG1438	arginine binding
H7F27_RS08900	COG0497	DNA recombination
H7F27_RS08905	COG0750	zinc metalloprotease
H7F27_RS08910	COG0745	RESPONSE REGULATOR receiver
H7F27_RS08915	COG1902	pentaerythritol trinitrate reductase activity
H7F27_RS08930	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F27_RS08935	COG0584	glycerophosphoryl diester phosphodiesterase
H7F27_RS08940	COG0183	Belongs to the thiolase family
H7F27_RS08945	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F27_RS08950	COG1960	acyl-CoA dehydrogenase activity
H7F27_RS08955	COG0372	Belongs to the citrate synthase family
H7F27_RS08960	COG2079	MmgE PrpD family protein
H7F27_RS08965	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7F27_RS08975	COG3829	transcription factor binding
H7F27_RS08975	COG3290	protein histidine kinase activity
H7F27_RS08980	COG0280	phosphate acetyltransferase
H7F27_RS08990	COG3426	butyrate kinase activity
H7F27_RS08995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F27_RS09000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F27_RS09005	COG0022	dehydrogenase e1 component
H7F27_RS09010	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F27_RS09015	COG0789	Transcriptional regulator
H7F27_RS09015	COG4978	Transcriptional regulator
H7F27_RS09020	COG2814	Major facilitator Superfamily
H7F27_RS09025	COG1597	lipid kinase activity
H7F27_RS09035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F27_RS09040	COG0765	amino acid transport
H7F27_RS09045	COG1126	abc transporter atp-binding protein
H7F27_RS09050	COG4129	membrane
H7F27_RS09055	COG1376	ErfK ybiS ycfS ynhG family protein
H7F27_RS09065	COG0346	lactoylglutathione lyase activity
H7F27_RS09070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7F27_RS09075	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7F27_RS09080	COG3361	conserved protein (COG2071)
H7F27_RS09085	COG0706	membrane insertase activity
H7F27_RS09095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7F27_RS09100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H7F27_RS09110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7F27_RS09115	COG1234	tRNA 3'-trailer cleavage
H7F27_RS09130	COG0596	Alpha beta hydrolase
H7F27_RS09135	COG1902	pentaerythritol trinitrate reductase activity
H7F27_RS09140	COG4187	Peptidase family M20/M25/M40
H7F27_RS09145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F27_RS09150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F27_RS09155	COG0300	oxidoreductase activity
H7F27_RS09160	COG3048	D-serine ammonia-lyase activity
H7F27_RS09165	COG1072	(Pantothenic acid kinase))
H7F27_RS09180	COG2211	Major facilitator Superfamily
H7F27_RS09195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7F27_RS09205	COG0456	acetyltransferase
H7F27_RS09210	COG2329	Antibiotic biosynthesis monooxygenase
H7F27_RS09215	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H7F27_RS09215	COG0456	acetyltransferase
H7F27_RS09220	COG4918	Iron-sulphur cluster biosynthesis
H7F27_RS09230	COG1073	alpha beta
H7F27_RS09240	COG0667	Aldo Keto reductase
H7F27_RS09250	COG0494	nUDIX hydrolase
H7F27_RS09255	COG1379	DNA repair
H7F27_RS09260	COG1396	sequence-specific DNA binding
H7F27_RS09265	COG0252	asparaginase activity
H7F27_RS09270	COG1027	Aspartate ammonia-lyase
H7F27_RS09275	COG1757	Na H antiporter
H7F27_RS09280	COG0281	malic enzyme
H7F27_RS09290	COG1300	Membrane
H7F27_RS09295	COG0735	belongs to the Fur family
H7F27_RS09305	COG4974	Belongs to the 'phage' integrase family
H7F27_RS09310	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7F27_RS09315	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7F27_RS09320	COG1686	Belongs to the peptidase S11 family
H7F27_RS09325	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F27_RS09330	COG2172	sigma factor antagonist activity
H7F27_RS09335	COG1191	sigma factor activity
H7F27_RS09355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F27_RS09370	COG0697	spore germination
H7F27_RS09375	COG0019	diaminopimelate decarboxylase activity
H7F27_RS09380	COG4086	secreted protein
H7F27_RS09385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7F27_RS09390	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
H7F27_RS09395	COG0681	Belongs to the peptidase S26 family
H7F27_RS09405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F27_RS09405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F27_RS09410	COG0307	riboflavin synthase, alpha
H7F27_RS09415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F27_RS09415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F27_RS09420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7F27_RS09425	COG0456	acetyltransferase
H7F27_RS09430	COG1547	Domain of unknown function (DUF309)
H7F27_RS09440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7F27_RS09445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7F27_RS09455	COG1686	Belongs to the peptidase S11 family
H7F27_RS09460	COG2715	membrane protein required for spore maturation
H7F27_RS09465	COG0700	Nucleoside recognition
H7F27_RS09470	COG1187	pseudouridine synthase activity
H7F27_RS09475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F27_RS09480	COG1333	cytochrome c biogenesis protein
H7F27_RS09485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7F27_RS09490	COG0745	RESPONSE REGULATOR receiver
H7F27_RS09495	COG5002	protein histidine kinase activity
H7F27_RS09500	COG1595	DNA-templated transcription, initiation
H7F27_RS09510	COG0710	3-dehydroquinate dehydratase activity
H7F27_RS09515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7F27_RS09520	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H7F27_RS09525	COG1141	Ferredoxin
H7F27_RS09530	COG4955	Helix-turn-helix domain
H7F27_RS09535	COG0514	ATP-dependent DNA helicase (RecQ)
H7F27_RS09540	COG1266	CAAX protease self-immunity
H7F27_RS09545	COG1388	LysM domain
H7F27_RS09555	COG1408	metallophosphoesterase
H7F27_RS09560	COG4862	establishment of competence for transformation
H7F27_RS09565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F27_RS09570	COG0492	ferredoxin-NADP+ reductase activity
H7F27_RS09575	COG2339	peptidase activity
H7F27_RS09580	COG3773	Cell wall hydrolase
H7F27_RS09580	COG3409	Peptidoglycan-binding domain 1 protein
H7F27_RS09585	COG2959	enzyme of heme biosynthesis
H7F27_RS09590	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H7F27_RS09600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7F27_RS09605	COG0539	negative regulation of cytoplasmic translation
H7F27_RS09610	COG1304	FMN binding
H7F27_RS09635	COG1160	GTP binding
H7F27_RS09640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7F27_RS09655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H7F27_RS09660	COG0776	regulation of translation
H7F27_RS09665	COG0302	gtp cyclohydrolase
H7F27_RS09675	COG0142	geranyltranstransferase activity
H7F27_RS09680	COG2226	methyltransferase
H7F27_RS09685	COG0142	geranyltranstransferase activity
H7F27_RS09690	COG0105	UTP biosynthetic process
H7F27_RS09695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7F27_RS09700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7F27_RS09705	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7F27_RS09710	COG4401	Chorismate mutase type I
H7F27_RS09715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7F27_RS09720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7F27_RS09730	COG0135	phosphoribosylanthranilate isomerase activity
H7F27_RS09735	COG0133	tryptophan synthase activity
H7F27_RS09740	COG0159	tryptophan synthase activity
H7F27_RS09745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7F27_RS09750	COG0287	Prephenate dehydrogenase
H7F27_RS09755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7F27_RS09760	COG0457	Tetratricopeptide repeat
H7F27_RS09765	COG5582	Belongs to the UPF0302 family
H7F27_RS09775	COG0723	plastoquinol--plastocyanin reductase activity
H7F27_RS09780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7F27_RS09785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7F27_RS09785	COG2010	Cytochrome c
H7F27_RS09790	COG4347	Protein of unknown function (DUF1405)
H7F27_RS09800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F27_RS09805	COG1694	Mazg nucleotide pyrophosphohydrolase
H7F27_RS09810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7F27_RS09815	COG1803	Methylglyoxal synthase
H7F27_RS09820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F27_RS09825	COG0438	transferase activity, transferring glycosyl groups
H7F27_RS09830	COG0617	tRNA 3'-terminal CCA addition
H7F27_RS09835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H7F27_RS09835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H7F27_RS09840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7F27_RS09845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7F27_RS09850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H7F27_RS09865	COG5353	protein conserved in bacteria
H7F27_RS09870	COG0436	Aminotransferase
H7F27_RS09875	COG0017	Asparaginyl-tRNA synthetase
H7F27_RS09880	COG3935	DnaD domain protein
H7F27_RS09885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7F27_RS09895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F27_RS09895	COG4499	WXG100 protein secretion system (Wss), protein YukC
H7F27_RS09900	COG3331	DNA recombination
H7F27_RS09935	COG0071	Belongs to the small heat shock protein (HSP20) family
H7F27_RS09940	COG2190	(PTS) system
H7F27_RS09945	COG1205	dead DEAH box helicase
H7F27_RS09945	COG1111	helicase
H7F27_RS09950	COG3359	exonuclease
H7F27_RS09965	COG4474	Belongs to the UPF0398 family
H7F27_RS09980	COG0116	Belongs to the methyltransferase superfamily
H7F27_RS09995	COG1199	ATP-dependent helicase activity
H7F27_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS10005	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H7F27_RS10010	COG1609	Transcriptional regulator
H7F27_RS10015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F27_RS10020	COG0800	Aldolase
H7F27_RS10030	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7F27_RS10035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7F27_RS10040	COG2233	PERMEase
H7F27_RS10045	COG3424	synthase
H7F27_RS10050	COG1755	Isoprenylcysteine carboxyl methyltransferase
H7F27_RS10060	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H7F27_RS10075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F27_RS10085	COG0328	RNA-DNA hybrid ribonuclease activity
H7F27_RS10090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7F27_RS10095	COG0328	RNA-DNA hybrid ribonuclease activity
H7F27_RS10115	COG1278	Cold shock
H7F27_RS10125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7F27_RS10130	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7F27_RS10135	COG0386	Belongs to the glutathione peroxidase family
H7F27_RS10140	COG1418	mRNA catabolic process
H7F27_RS10145	COG1413	lyase activity
H7F27_RS10150	COG0129	dihydroxy-acid dehydratase activity
H7F27_RS10160	COG2521	methyltransferase
H7F27_RS10160	COG2136	Putative SAM-dependent methyltransferase
H7F27_RS10170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7F27_RS10180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7F27_RS10185	COG0204	Acyl-transferase
H7F27_RS10190	COG1272	protein, Hemolysin III
H7F27_RS10195	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7F27_RS10200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7F27_RS10210	COG1999	signal sequence binding
H7F27_RS10215	COG2755	lipolytic protein G-D-S-L family
H7F27_RS10220	COG4698	Protein conserved in bacteria
H7F27_RS10230	COG0534	Mate efflux family protein
H7F27_RS10235	COG1846	Transcriptional regulator
H7F27_RS10240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7F27_RS10250	COG1086	Polysaccharide biosynthesis protein
H7F27_RS10255	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
H7F27_RS10260	COG4641	Protein conserved in bacteria
H7F27_RS10275	COG0463	Glycosyl transferase, family 2
H7F27_RS10280	COG0456	acetyltransferase
H7F27_RS10290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7F27_RS10295	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7F27_RS10300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7F27_RS10305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7F27_RS10310	COG0456	acetyltransferase
H7F27_RS10315	COG1509	lysine 2,3-aminomutase activity
H7F27_RS10325	COG4479	Belongs to the UPF0346 family
H7F27_RS10345	COG0671	phosphoesterase, PA-phosphatase related
H7F27_RS10360	COG0813	purine-nucleoside phosphorylase activity
H7F27_RS10365	COG1876	peptidase activity
H7F27_RS10375	COG2226	methyltransferase
H7F27_RS10380	COG0793	Belongs to the peptidase S41A family
H7F27_RS10380	COG3409	Peptidoglycan-binding domain 1 protein
H7F27_RS10385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F27_RS10395	COG0346	lactoylglutathione lyase activity
H7F27_RS10400	COG0400	carboxylic ester hydrolase activity
H7F27_RS10405	COG0778	Nitroreductase
H7F27_RS10410	COG1733	regulation of RNA biosynthetic process
H7F27_RS10420	COG1942	4-Oxalocrotonate Tautomerase
H7F27_RS10440	COG2962	Rard protein
H7F27_RS10450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F27_RS10455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F27_RS10460	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F27_RS10465	COG0534	Mate efflux family protein
H7F27_RS10470	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H7F27_RS10475	COG1819	glycosyl
H7F27_RS10485	COG2032	superoxide dismutase activity
H7F27_RS10490	COG0714	Associated with various cellular activities
H7F27_RS10500	COG0567	Dehydrogenase, E1 component
H7F27_RS10505	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F27_RS10510	COG0385	Bile acid
H7F27_RS10515	COG0733	neurotransmitter:sodium symporter activity
H7F27_RS10520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7F27_RS10525	COG1657	PFAM Prenyltransferase squalene oxidase
H7F27_RS10530	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS10545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7F27_RS10550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7F27_RS10560	COG0514	ATP-dependent DNA helicase (RecQ)
H7F27_RS10565	COG3584	3D domain protein
H7F27_RS10565	COG1388	LysM domain
H7F27_RS10575	COG2197	response regulator
H7F27_RS10580	COG4585	Histidine kinase
H7F27_RS10585	COG3239	Fatty acid desaturase
H7F27_RS10590	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7F27_RS10605	COG2322	membrane
H7F27_RS10610	COG0741	lytic transglycosylase activity
H7F27_RS10615	COG0640	Transcriptional regulator
H7F27_RS10625	COG2378	regulation of single-species biofilm formation
H7F27_RS10630	COG3708	Transcriptional regulator
H7F27_RS10635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F27_RS10640	COG1309	transcriptional regulator
H7F27_RS10645	COG0456	acetyltransferase
H7F27_RS10650	COG2207	Transcriptional regulator
H7F27_RS10650	COG0662	Cupin 2, conserved barrel domain protein
H7F27_RS10655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F27_RS10665	COG1733	regulation of RNA biosynthetic process
H7F27_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS10705	COG0457	Tetratricopeptide repeat
H7F27_RS10745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F27_RS10750	COG2318	DinB family
H7F27_RS10755	COG3397	chitin binding
H7F27_RS10770	COG2211	Major facilitator Superfamily
H7F27_RS10775	COG3507	Belongs to the glycosyl hydrolase 43 family
H7F27_RS10790	COG1070	Carbohydrate kinase
H7F27_RS10805	COG1231	oxidoreductase activity
H7F27_RS10810	COG1525	nuclease
H7F27_RS10815	COG2814	Major facilitator Superfamily
H7F27_RS10855	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS10865	COG3619	membrane
H7F27_RS10870	COG4305	rare lipoprotein A
H7F27_RS10880	COG0243	molybdopterin cofactor binding
H7F27_RS10885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7F27_RS10890	COG1070	Carbohydrate kinase
H7F27_RS10895	COG2814	Major facilitator Superfamily
H7F27_RS10905	COG1131	(ABC) transporter
H7F27_RS10930	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H7F27_RS10935	COG0300	oxidoreductase activity
H7F27_RS10960	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7F27_RS10965	COG0583	DNA-binding transcription factor activity
H7F27_RS10970	COG0067	glutamate synthase
H7F27_RS10970	COG0069	glutamate synthase activity
H7F27_RS10970	COG0070	glutamate synthase
H7F27_RS10975	COG0493	'glutamate synthase
H7F27_RS10980	COG0604	alcohol dehydrogenase
H7F27_RS10985	COG0583	DNA-binding transcription factor activity
H7F27_RS10990	COG0405	Gamma-glutamyltransferase
H7F27_RS10995	COG0166	Belongs to the GPI family
H7F27_RS11000	COG0582	viral genome integration into host DNA
H7F27_RS11015	COG0534	Mate efflux family protein
H7F27_RS11020	COG2017	converts alpha-aldose to the beta-anomer
H7F27_RS11025	COG2027	D-alanyl-D-alanine carboxypeptidase
H7F27_RS11030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS11040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS11045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS11060	COG1649	PFAM Uncharacterised BCR, COG1649
H7F27_RS11070	COG1960	acyl-CoA dehydrogenase activity
H7F27_RS11075	COG0318	PFAM AMP-dependent synthetase and ligase
H7F27_RS11080	COG0439	Biotin carboxylase
H7F27_RS11085	COG0511	ligase activity, forming carbon-carbon bonds
H7F27_RS11090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7F27_RS11095	COG1024	Enoyl-CoA hydratase
H7F27_RS11100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7F27_RS11105	COG2404	hydrolase activity, acting on ester bonds
H7F27_RS11110	COG0586	Pfam SNARE associated Golgi protein
H7F27_RS11115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7F27_RS11120	COG2246	polysaccharide biosynthetic process
H7F27_RS11135	COG3507	Belongs to the glycosyl hydrolase 43 family
H7F27_RS11140	COG5520	Belongs to the glycosyl hydrolase 30 family
H7F27_RS11155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H7F27_RS11160	COG1115	amino acid carrier protein
H7F27_RS11170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7F27_RS11180	COG1832	CoA-binding protein
H7F27_RS11185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7F27_RS11190	COG4841	protein insertion into membrane
H7F27_RS11200	COG0824	Thioesterase
H7F27_RS11220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F27_RS11225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H7F27_RS11240	COG0071	Belongs to the small heat shock protein (HSP20) family
H7F27_RS11250	COG4846	Membrane protein involved in cytochrome C biogenesis
H7F27_RS11255	COG2201	protein-glutamate methylesterase activity
H7F27_RS11260	COG0785	Cytochrome C biogenesis protein
H7F27_RS11270	COG3763	UPF0154 protein
H7F27_RS11280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7F27_RS11285	COG4224	UPF0291 protein
H7F27_RS11290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7F27_RS11295	COG1388	LysM domain
H7F27_RS11300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7F27_RS11310	COG0346	lactoylglutathione lyase activity
H7F27_RS11330	COG4195	phage-related replication protein
H7F27_RS11360	COG3832	glyoxalase III activity
H7F27_RS11370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7F27_RS11390	COG5434	Belongs to the glycosyl hydrolase 28 family
H7F27_RS11395	COG2135	peptidase activity
H7F27_RS11405	COG3655	Transcriptional regulator
H7F27_RS11410	COG3739	integral membrane protein
H7F27_RS11415	COG2720	vancomycin resistance protein
H7F27_RS11420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7F27_RS11445	COG0726	polysaccharide deacetylase
H7F27_RS11470	COG0457	Tetratricopeptide repeat
H7F27_RS11485	COG2273	Hydrolase Family 16
H7F27_RS11560	COG0583	DNA-binding transcription factor activity
H7F27_RS11565	COG0697	spore germination
H7F27_RS11570	COG1388	LysM domain
H7F27_RS11595	COG0174	glutamine synthetase
H7F27_RS11600	COG0789	Transcriptional regulator
H7F27_RS11605	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H7F27_RS11610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7F27_RS11615	COG0464	growth
H7F27_RS11620	COG1131	(ABC) transporter
H7F27_RS11625	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F27_RS11630	COG4112	unkown
H7F27_RS11635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F27_RS11640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F27_RS11645	COG1780	Probably involved in ribonucleotide reductase function
H7F27_RS11665	COG1923	regulation of RNA biosynthetic process
H7F27_RS11670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7F27_RS11695	COG1764	response to oxidative stress
H7F27_RS11700	COG4195	phage-related replication protein
H7F27_RS11705	COG1404	Belongs to the peptidase S8 family
H7F27_RS11715	COG2124	cytochrome p450
H7F27_RS11720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F27_RS11720	COG3321	synthase
H7F27_RS11720	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H7F27_RS11720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7F27_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS11725	COG3321	synthase
H7F27_RS11725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS11725	COG4221	oxidoreductase activity
H7F27_RS11730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F27_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS11730	COG3321	synthase
H7F27_RS11730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F27_RS11730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS11735	COG0300	oxidoreductase activity
H7F27_RS11735	COG4221	oxidoreductase activity
H7F27_RS11735	COG3321	synthase
H7F27_RS11735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F27_RS11740	COG0300	oxidoreductase activity
H7F27_RS11740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS11740	COG3321	synthase
H7F27_RS11740	COG0318	PFAM AMP-dependent synthetase and ligase
H7F27_RS11745	COG1024	Enoyl-CoA hydratase
H7F27_RS11750	COG1024	Enoyl-CoA hydratase
H7F27_RS11755	COG3425	synthase
H7F27_RS11760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F27_RS11765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F27_RS11770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7F27_RS11770	COG2070	2-Nitropropane dioxygenase
H7F27_RS11775	COG3321	synthase
H7F27_RS11780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7F27_RS11785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F27_RS11790	COG3226	Transcriptional regulator
H7F27_RS11850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7F27_RS11855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7F27_RS11865	COG4550	Control of competence regulator ComK, YlbF/YmcA
H7F27_RS11870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7F27_RS11875	COG0156	8-amino-7-oxononanoate synthase activity
H7F27_RS11880	COG1063	alcohol dehydrogenase
H7F27_RS11885	COG2359	stage V sporulation protein S
H7F27_RS11890	COG1692	metallophosphoesterase
H7F27_RS11895	COG1418	mRNA catabolic process
H7F27_RS11900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7F27_RS11905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7F27_RS11910	COG1058	Belongs to the CinA family
H7F27_RS11910	COG1546	Belongs to the CinA family
H7F27_RS11915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7F27_RS11920	COG1426	Protein conserved in bacteria
H7F27_RS11935	COG0300	oxidoreductase activity
H7F27_RS11940	COG0612	Peptidase, M16
H7F27_RS11945	COG0612	Peptidase, M16
H7F27_RS11950	COG2814	Major facilitator Superfamily
H7F27_RS11955	COG2188	Transcriptional regulator
H7F27_RS11960	COG4980	gas vesicle protein
H7F27_RS11960	COG1674	ftsk spoiiie
H7F27_RS11970	COG0740	serine-type endopeptidase activity
H7F27_RS11975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H7F27_RS11980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7F27_RS11985	COG0527	aspartate kinase activity
H7F27_RS11990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7F27_RS11995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7F27_RS12000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F27_RS12005	COG1873	PFAM PRC-barrel domain
H7F27_RS12010	COG0612	Peptidase, M16
H7F27_RS12015	COG0726	polysaccharide deacetylase
H7F27_RS12020	COG1185	polyribonucleotide nucleotidyltransferase activity
H7F27_RS12030	COG0196	riboflavin kinase activity
H7F27_RS12035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7F27_RS12040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7F27_RS12045	COG1550	Protein conserved in bacteria
H7F27_RS12050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7F27_RS12055	COG1358	cellular component organization or biogenesis
H7F27_RS12060	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H7F27_RS12065	COG0195	Participates in both transcription termination and antitermination
H7F27_RS12070	COG0779	Required for maturation of 30S ribosomal subunits
H7F27_RS12075	COG2176	DNA-directed DNA polymerase activity
H7F27_RS12080	COG0442	prolyl-tRNA aminoacylation
H7F27_RS12085	COG0750	zinc metalloprotease
H7F27_RS12090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7F27_RS12095	COG4589	Belongs to the CDS family
H7F27_RS12100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7F27_RS12105	COG0233	cytoplasmic translational termination
H7F27_RS12110	COG0528	UMP kinase activity
H7F27_RS12115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7F27_RS12120	COG0052	Belongs to the universal ribosomal protein uS2 family
H7F27_RS12135	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H7F27_RS12140	COG1776	CheC inhibitor of MCP methylation
H7F27_RS12145	COG0835	chemotaxis
H7F27_RS12155	COG2201	protein-glutamate methylesterase activity
H7F27_RS12160	COG0455	bacterial-type flagellum organization
H7F27_RS12165	COG1419	protein localization to endoplasmic reticulum
H7F27_RS12170	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7F27_RS12175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7F27_RS12180	COG1684	flagellar biosynthetic protein fliR
H7F27_RS12185	COG1987	bacterial-type flagellum assembly
H7F27_RS12190	COG1338	Plays a role in the flagellum-specific transport system
H7F27_RS12195	COG3190	flagellar
H7F27_RS12200	COG2201	protein-glutamate methylesterase activity
H7F27_RS12205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7F27_RS12205	COG1776	CheC inhibitor of MCP methylation
H7F27_RS12210	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7F27_RS12215	COG1580	Controls the rotational direction of flagella during chemotaxis
H7F27_RS12220	COG1582	Flagellar protein (FlbD)
H7F27_RS12225	COG4786	Flagellar basal body rod
H7F27_RS12230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7F27_RS12235	COG3144	bacterial-type flagellum assembly
H7F27_RS12240	COG3334	PFAM MgtE intracellular
H7F27_RS12245	COG2882	bacterial-type flagellum organization
H7F27_RS12250	COG1157	protein secretion by the type III secretion system
H7F27_RS12255	COG1317	bacterial-type flagellum organization
H7F27_RS12260	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7F27_RS12265	COG1766	The M ring may be actively involved in energy transduction
H7F27_RS12270	COG1677	Flagellar hook-basal body complex protein FliE
H7F27_RS12275	COG1558	bacterial-type flagellum-dependent cell motility
H7F27_RS12280	COG1815	bacterial-type flagellum-dependent cell motility
H7F27_RS12285	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H7F27_RS12290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7F27_RS12295	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7F27_RS12300	COG4974	Belongs to the 'phage' integrase family
H7F27_RS12305	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H7F27_RS12310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7F27_RS12315	COG0758	DNA mediated transformation
H7F27_RS12320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7F27_RS12325	COG0045	succinate-CoA ligase (ADP-forming) activity
H7F27_RS12330	COG2257	FlhB HrpN YscU SpaS Family
H7F27_RS12340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7F27_RS12345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7F27_RS12350	COG0335	large ribosomal subunit rRNA binding
H7F27_RS12355	COG0336	Belongs to the RNA methyltransferase TrmD family
H7F27_RS12360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7F27_RS12370	COG1837	Belongs to the UPF0109 family
H7F27_RS12375	COG0228	four-way junction DNA binding
H7F27_RS12380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7F27_RS12385	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H7F27_RS12395	COG0552	protein localization to endoplasmic reticulum
H7F27_RS12405	COG0571	ribonuclease III activity
H7F27_RS12415	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS12420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7F27_RS12425	COG0416	fatty acid biosynthetic process
H7F27_RS12430	COG1349	DNA-binding transcription factor activity
H7F27_RS12430	COG2050	protein possibly involved in aromatic compounds catabolism
H7F27_RS12435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7F27_RS12440	COG1760	l-serine dehydratase
H7F27_RS12445	COG1760	l-serine dehydratase
H7F27_RS12450	COG1461	Dihydroxyacetone kinase
H7F27_RS12455	COG1302	Protein conserved in bacteria
H7F27_RS12460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7F27_RS12470	COG1564	THIamine pyrophosphokinase
H7F27_RS12475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7F27_RS12480	COG1162	GTPase activity
H7F27_RS12485	COG0515	serine threonine protein kinase
H7F27_RS12485	COG2815	serine threonine protein kinase
H7F27_RS12490	COG0631	protein serine/threonine phosphatase activity
H7F27_RS12495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7F27_RS12500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7F27_RS12500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7F27_RS12505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7F27_RS12510	COG0242	peptide deformylase activity
H7F27_RS12515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7F27_RS12520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7F27_RS12525	COG1758	RNA polymerase activity
H7F27_RS12530	COG0194	GDP metabolic process
H7F27_RS12540	COG1561	YicC-like family, N-terminal region
H7F27_RS12545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7F27_RS12555	COG1648	precorrin-2 dehydrogenase activity
H7F27_RS12560	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H7F27_RS12565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7F27_RS12570	COG0529	Catalyzes the synthesis of activated sulfate
H7F27_RS12575	COG2046	Belongs to the sulfate adenylyltransferase family
H7F27_RS12580	COG0306	phosphate transporter
H7F27_RS12585	COG0175	sulfate reduction
H7F27_RS12590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7F27_RS12595	COG0284	orotidine-5'-phosphate decarboxylase activity
H7F27_RS12600	COG0167	dihydroorotate dehydrogenase activity
H7F27_RS12605	COG0543	2 iron, 2 sulfur cluster binding
H7F27_RS12610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7F27_RS12615	COG0505	Belongs to the CarA family
H7F27_RS12620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7F27_RS12625	COG0540	Belongs to the ATCase OTCase family
H7F27_RS12630	COG2233	PERMEase
H7F27_RS12635	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H7F27_RS12640	COG0564	pseudouridine synthase activity
H7F27_RS12645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7F27_RS12650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7F27_RS12655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7F27_RS12660	COG3599	regulation of cell shape
H7F27_RS12665	COG2302	S4 RNA-binding domain
H7F27_RS12670	COG0762	integral membrane protein
H7F27_RS12675	COG1799	cell septum assembly
H7F27_RS12680	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7F27_RS12685	COG1496	oxidoreductase activity
H7F27_RS12690	COG1873	PFAM PRC-barrel domain
H7F27_RS12695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7F27_RS12700	COG1119	ATPase activity
H7F27_RS12705	COG1191	sigma factor activity
H7F27_RS12710	COG1191	sigma factor activity
H7F27_RS12720	COG4412	M6 family metalloprotease domain protein
H7F27_RS12720	COG1404	Belongs to the peptidase S8 family
H7F27_RS12725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7F27_RS12730	COG0849	cell division
H7F27_RS12735	COG3856	small basic protein
H7F27_RS12740	COG3879	Bacterial protein of unknown function (DUF881)
H7F27_RS12745	COG3879	Bacterial protein of unknown function (DUF881)
H7F27_RS12750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7F27_RS12755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7F27_RS12760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7F27_RS12765	COG0772	Belongs to the SEDS family
H7F27_RS12770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7F27_RS12775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7F27_RS12780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7F27_RS12785	COG0768	penicillin binding
H7F27_RS12790	COG0768	penicillin binding
H7F27_RS12795	COG4839	cell division protein FtsL
H7F27_RS12800	COG0275	rRNA processing
H7F27_RS12805	COG2001	Belongs to the MraZ family
H7F27_RS12810	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H7F27_RS12815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7F27_RS12820	COG0454	-acetyltransferase
H7F27_RS12835	COG1399	metal-binding, possibly nucleic acid-binding protein
H7F27_RS12840	COG1323	Belongs to the UPF0348 family
H7F27_RS12850	COG3480	Lon protease (S16) C-terminal proteolytic domain
H7F27_RS12855	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7F27_RS12860	COG3314	Sporulation integral membrane protein YlbJ
H7F27_RS12865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7F27_RS12870	COG0742	ribosomal rna small subunit methyltransferase
H7F27_RS12875	COG4471	UPF0298 protein
H7F27_RS12880	COG3679	Belongs to the UPF0342 family
H7F27_RS12895	COG2340	Cysteine-rich secretory protein family
H7F27_RS12900	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H7F27_RS12910	COG3336	cytochrome c oxidase
H7F27_RS12915	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7F27_RS12920	COG1845	cytochrome c oxidase, subunit III
H7F27_RS12925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7F27_RS12930	COG2010	Cytochrome c
H7F27_RS12930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7F27_RS12935	COG0109	protoheme IX farnesyltransferase activity
H7F27_RS12940	COG1612	heme a metabolic process
H7F27_RS12945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H7F27_RS12950	COG0772	Belongs to the SEDS family
H7F27_RS12955	COG4838	Belongs to the UPF0358 family
H7F27_RS12960	COG2066	Belongs to the glutaminase family
H7F27_RS12965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7F27_RS12970	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7F27_RS12980	COG4896	Protein conserved in bacteria
H7F27_RS12990	COG1217	gtp-binding protein TYPA
H7F27_RS13020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7F27_RS13030	COG0483	inositol monophosphate 1-phosphatase activity
H7F27_RS13040	COG4493	Belongs to the UPF0637 family
H7F27_RS13045	COG4476	Belongs to the UPF0223 family
H7F27_RS13050	COG1982	Orn Lys Arg decarboxylase major
H7F27_RS13060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F27_RS13065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F27_RS13070	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F27_RS13075	COG0022	dehydrogenase e1 component
H7F27_RS13080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F27_RS13085	COG0497	DNA recombination
H7F27_RS13095	COG0242	peptide deformylase activity
H7F27_RS13100	COG0561	phosphatase activity
H7F27_RS13105	COG5503	Protein of unknown function (DUF1447)
H7F27_RS13110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H7F27_RS13115	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7F27_RS13120	COG0569	domain protein
H7F27_RS13125	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H7F27_RS13125	COG2105	PFAM AIG2 family protein
H7F27_RS13130	COG3852	Histidine kinase
H7F27_RS13135	COG2002	toxin-antitoxin pair type II binding
H7F27_RS13140	COG1077	Cell shape determining protein MreB Mrl
H7F27_RS13150	COG2309	aminopeptidase activity
H7F27_RS13155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7F27_RS13160	COG0488	(ABC) transporter
H7F27_RS13170	COG0681	Belongs to the peptidase S26 family
H7F27_RS13175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F27_RS13175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F27_RS13175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F27_RS13180	COG1105	Belongs to the carbohydrate kinase PfkB family
H7F27_RS13185	COG1349	DNA-binding transcription factor activity
H7F27_RS13190	COG0577	efflux transmembrane transporter activity
H7F27_RS13195	COG1136	(ABC) transporter
H7F27_RS13200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F27_RS13210	COG1132	(ABC) transporter
H7F27_RS13215	COG1132	(ABC) transporter
H7F27_RS13220	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7F27_RS13230	COG1763	Mo-molybdopterin cofactor biosynthetic process
H7F27_RS13235	COG0303	'Molybdopterin
H7F27_RS13240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7F27_RS13245	COG0746	molybdenum cofactor guanylyltransferase activity
H7F27_RS13260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F27_RS13265	COG0450	alkyl hydroperoxide reductase
H7F27_RS13270	COG0668	transmembrane transport
H7F27_RS13280	COG1473	amidohydrolase
H7F27_RS13285	COG2171	N-acyltransferase activity
H7F27_RS13290	COG0716	FMN binding
H7F27_RS13300	COG0716	FMN binding
H7F27_RS13305	COG0583	DNA-binding transcription factor activity
H7F27_RS13310	COG0517	IMP dehydrogenase activity
H7F27_RS13320	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H7F27_RS13325	COG4703	Protein of unknown function (DUF1797)
H7F27_RS13330	COG3546	catalase activity
H7F27_RS13335	COG2200	EAL domain
H7F27_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS13345	COG1408	metallophosphoesterase
H7F27_RS13350	COG1376	ErfK ybiS ycfS ynhG family protein
H7F27_RS13355	COG2814	Major facilitator Superfamily
H7F27_RS13365	COG0784	Response regulator, receiver
H7F27_RS13365	COG0835	chemotaxis
H7F27_RS13375	COG0436	Aminotransferase
H7F27_RS13380	COG4191	Histidine kinase
H7F27_RS13385	COG0768	penicillin binding
H7F27_RS13390	COG2340	Cysteine-rich secretory protein family
H7F27_RS13395	COG2084	Dehydrogenase
H7F27_RS13400	COG0840	transmembrane signaling receptor activity
H7F27_RS13405	COG0456	acetyltransferase
H7F27_RS13410	COG1533	DNA photolyase activity
H7F27_RS13420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7F27_RS13425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F27_RS13430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS13430	COG1263	PTS System
H7F27_RS13430	COG2190	(PTS) system
H7F27_RS13435	COG3711	transcriptional antiterminator
H7F27_RS13440	COG1609	Transcriptional regulator
H7F27_RS13445	COG0006	proline dipeptidase activity
H7F27_RS13455	COG2217	Heavy metal translocating P-type atpase
H7F27_RS13460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F27_RS13465	COG2244	polysaccharide biosynthetic process
H7F27_RS13470	COG3773	Cell wall hydrolase
H7F27_RS13480	COG4873	Protein conserved in bacteria
H7F27_RS13490	COG3858	chitin binding
H7F27_RS13495	COG1388	LysM domain
H7F27_RS13500	COG1388	LysM domain
H7F27_RS13500	COG4641	Protein conserved in bacteria
H7F27_RS13505	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7F27_RS13510	COG0602	queuosine metabolic process
H7F27_RS13515	COG0720	synthase
H7F27_RS13520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7F27_RS13525	COG3949	Membrane
H7F27_RS13530	COG0542	response to heat
H7F27_RS13535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7F27_RS13540	COG1360	Flagellar Motor Protein
H7F27_RS13545	COG1846	Transcriptional regulator
H7F27_RS13550	COG3852	Histidine kinase
H7F27_RS13565	COG3339	Conserved Protein
H7F27_RS13570	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H7F27_RS13575	COG0235	Class ii aldolase
H7F27_RS13580	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
H7F27_RS13585	COG1850	ribulose-bisphosphate carboxylase activity
H7F27_RS13590	COG0436	Aminotransferase
H7F27_RS13595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7F27_RS13600	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H7F27_RS13605	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7F27_RS13615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7F27_RS13620	COG5002	protein histidine kinase activity
H7F27_RS13625	COG3594	Acyltransferase
H7F27_RS13640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7F27_RS13645	COG0501	Belongs to the peptidase M48B family
H7F27_RS13665	COG1191	sigma factor activity
H7F27_RS13670	COG0861	Integral membrane protein TerC family
H7F27_RS13675	COG0586	Pfam SNARE associated Golgi protein
H7F27_RS13680	COG5001	Diguanylate cyclase
H7F27_RS13680	COG3300	MHYT domain
H7F27_RS13685	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7F27_RS13690	COG1793	dna ligase
H7F27_RS13690	COG3285	dna ligase
H7F27_RS13705	COG1408	metallophosphoesterase
H7F27_RS13710	COG0726	polysaccharide deacetylase
H7F27_RS13715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7F27_RS13720	COG1846	Transcriptional regulator
H7F27_RS13735	COG0789	Transcriptional regulator
H7F27_RS13740	COG2239	Acts as a magnesium transporter
H7F27_RS13750	COG3212	peptidase
H7F27_RS13755	COG3212	peptidase
H7F27_RS13760	COG3850	Histidine kinase
H7F27_RS13760	COG5002	protein histidine kinase activity
H7F27_RS13765	COG0745	RESPONSE REGULATOR receiver
H7F27_RS13775	COG4721	ABC-type cobalt transport system, permease component
H7F27_RS13780	COG1122	ATPase activity
H7F27_RS13785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H7F27_RS13790	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F27_RS13795	COG1404	Belongs to the peptidase S8 family
H7F27_RS13800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7F27_RS13805	COG0406	alpha-ribazole phosphatase activity
H7F27_RS13810	COG0590	tRNA wobble adenosine to inosine editing
H7F27_RS13815	COG0457	Tetratricopeptide repeat
H7F27_RS13815	COG0463	Glycosyl transferase, family 2
H7F27_RS13820	COG1764	response to oxidative stress
H7F27_RS13825	COG1846	Transcriptional regulator
H7F27_RS13830	COG1764	response to oxidative stress
H7F27_RS13835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7F27_RS13840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7F27_RS13845	COG0788	formyltetrahydrofolate deformylase activity
H7F27_RS13850	COG2076	Multidrug Resistance protein
H7F27_RS13855	COG2076	Multidrug Resistance protein
H7F27_RS13860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F27_RS13865	COG2318	DinB family
H7F27_RS13870	COG2323	membrane
H7F27_RS13880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7F27_RS13880	COG1017	nitric oxide dioxygenase activity
H7F27_RS13885	COG1607	acyl-coa hydrolase
H7F27_RS13890	COG1834	amidinotransferase
H7F27_RS13895	COG2706	6-phosphogluconolactonase activity
H7F27_RS13900	COG4608	Belongs to the ABC transporter superfamily
H7F27_RS13905	COG0791	NLP P60 protein
H7F27_RS13910	COG4948	Mandelate Racemase Muconate Lactonizing
H7F27_RS13915	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7F27_RS13920	COG4166	transmembrane transport
H7F27_RS13925	COG0444	Belongs to the ABC transporter superfamily
H7F27_RS13930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F27_RS13935	COG0601	transmembrane transport
H7F27_RS13940	COG2362	D-Aminopeptidase
H7F27_RS13945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F27_RS13950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F27_RS13960	COG0463	Glycosyl transferase, family 2
H7F27_RS13965	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7F27_RS13970	COG0346	lactoylglutathione lyase activity
H7F27_RS13975	COG0531	amino acid
H7F27_RS13980	COG1392	Phosphate transport regulator
H7F27_RS13985	COG0306	phosphate transporter
H7F27_RS14045	COG3778	Protein conserved in bacteria
H7F27_RS14050	COG3299	homolog of phage Mu protein gp47
H7F27_RS14055	COG3628	GPW Gp25 family protein
H7F27_RS14065	COG4193	domain, Protein
H7F27_RS14070	COG1652	LysM domain
H7F27_RS14075	COG5412	phage tail tape measure protein
H7F27_RS14075	COG3953	SLT domain
H7F27_RS14125	COG4653	Phage capsid family
H7F27_RS14130	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7F27_RS14135	COG5518	Phage portal protein
H7F27_RS14140	COG1783	phage Terminase large subunit
H7F27_RS14145	COG3728	DNA packaging
H7F27_RS14145	COG5484	DNA packaging
H7F27_RS14150	COG1595	DNA-templated transcription, initiation
H7F27_RS14170	COG1484	DNA-dependent DNA replication
H7F27_RS14175	COG1522	sequence-specific DNA binding
H7F27_RS14185	COG1396	sequence-specific DNA binding
H7F27_RS14190	COG2856	Zn peptidase
H7F27_RS14195	COG3546	catalase activity
H7F27_RS14200	COG4195	phage-related replication protein
H7F27_RS14210	COG3409	Peptidoglycan-binding domain 1 protein
H7F27_RS14210	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F27_RS14210	COG1388	LysM domain
H7F27_RS14215	COG2350	Protein conserved in bacteria
H7F27_RS14225	COG0457	Tetratricopeptide repeat
H7F27_RS14230	COG2318	DinB family
H7F27_RS14235	COG0730	response to heat
H7F27_RS14240	COG2721	sulfolactate sulfo-lyase activity
H7F27_RS14245	COG0246	Mannitol dehydrogenase
H7F27_RS14250	COG1609	Transcriptional regulator
H7F27_RS14255	COG2271	Major facilitator Superfamily
H7F27_RS14260	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS14265	COG1312	Catalyzes the dehydration of D-mannonate
H7F27_RS14270	COG1063	alcohol dehydrogenase
H7F27_RS14275	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H7F27_RS14280	COG2211	Major facilitator Superfamily
H7F27_RS14285	COG1904	glucuronate isomerase
H7F27_RS14290	COG1252	NADH dehydrogenase
H7F27_RS14300	COG4297	protein containing double-stranded beta helix domain
H7F27_RS14305	COG0697	spore germination
H7F27_RS14310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7F27_RS14315	COG0390	transport system, permease component
H7F27_RS14320	COG1587	Uroporphyrinogen-III synthase
H7F27_RS14335	COG1819	glycosyl
H7F27_RS14340	COG2124	cytochrome p450
H7F27_RS14350	COG1051	belongs to the nudix hydrolase family
H7F27_RS14360	COG2427	Protein of unknown function (DUF1641)
H7F27_RS14365	COG3383	formate dehydrogenase (NAD+) activity
H7F27_RS14375	COG2205	protein histidine kinase activity
H7F27_RS14380	COG5504	Zn-dependent protease
H7F27_RS14395	COG0726	polysaccharide deacetylase
H7F27_RS14405	COG0109	protoheme IX farnesyltransferase activity
H7F27_RS14425	COG0789	Transcriptional regulator
H7F27_RS14435	COG0697	spore germination
H7F27_RS14440	COG0583	DNA-binding transcription factor activity
H7F27_RS14445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F27_RS14465	COG3409	Peptidoglycan-binding domain 1 protein
H7F27_RS14495	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7F27_RS14510	COG5505	Protein of unknown function (DUF819)
H7F27_RS14515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F27_RS14520	COG0626	cystathionine gamma-synthase activity
H7F27_RS14525	COG0626	cystathionine gamma-synthase activity
H7F27_RS14530	COG2382	esterase
H7F27_RS14535	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H7F27_RS14540	COG2153	protein acetylation
H7F27_RS14550	COG0210	DNA helicase
H7F27_RS14605	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7F27_RS14610	COG0351	phosphomethylpyrimidine kinase
H7F27_RS14615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7F27_RS14620	COG2022	thiamine diphosphate biosynthetic process
H7F27_RS14625	COG2104	thiamine diphosphate biosynthetic process
H7F27_RS14630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7F27_RS14635	COG0352	thiamine-phosphate diphosphorylase activity
H7F27_RS14640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7F27_RS14645	COG0475	glutathione-regulated potassium exporter activity
H7F27_RS14645	COG0569	domain protein
H7F27_RS14650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7F27_RS14655	COG0564	pseudouridine synthase activity
H7F27_RS14660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7F27_RS14665	COG2357	RelA SpoT domain protein
H7F27_RS14675	COG4116	CYTH
H7F27_RS14680	COG0741	lytic transglycosylase activity
H7F27_RS14685	COG2346	COG2346, Truncated hemoglobins
H7F27_RS14690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7F27_RS14700	COG1164	Oligoendopeptidase f
H7F27_RS14705	COG4469	Competence protein
H7F27_RS14710	COG4862	establishment of competence for transformation
H7F27_RS14720	COG0861	Integral membrane protein TerC family
H7F27_RS14725	COG1393	Belongs to the ArsC family
H7F27_RS14730	COG0456	acetyltransferase
H7F27_RS14735	COG2814	Major facilitator Superfamily
H7F27_RS14740	COG4608	Belongs to the ABC transporter superfamily
H7F27_RS14745	COG0444	Belongs to the ABC transporter superfamily
H7F27_RS14750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F27_RS14755	COG0601	transmembrane transport
H7F27_RS14760	COG4166	transmembrane transport
H7F27_RS14765	COG0180	Tryptophanyl-tRNA synthetase
H7F27_RS14775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F27_RS14780	COG0601	transmembrane transport
H7F27_RS14790	COG4608	Belongs to the ABC transporter superfamily
H7F27_RS14795	COG0444	Belongs to the ABC transporter superfamily
H7F27_RS14800	COG5504	Zn-dependent protease
H7F27_RS14805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F27_RS14810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F27_RS14825	COG1744	ABC transporter substrate-binding protein PnrA-like
H7F27_RS14835	COG2267	carboxylic ester hydrolase activity
H7F27_RS14850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7F27_RS14855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7F27_RS14860	COG0505	Belongs to the CarA family
H7F27_RS14865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7F27_RS14875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H7F27_RS14880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7F27_RS14885	COG2271	Major facilitator Superfamily
H7F27_RS14890	COG0277	FAD linked oxidase domain protein
H7F27_RS14900	COG2151	metal-sulfur cluster biosynthetic enzyme
H7F27_RS14905	COG1073	alpha beta
H7F27_RS14910	COG0561	phosphatase activity
H7F27_RS14930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F27_RS14935	COG1307	EDD domain protein, DegV family
H7F27_RS14940	COG3227	Zinc metalloprotease (Elastase)
H7F27_RS14955	COG1695	Transcriptional regulator
H7F27_RS14975	COG2996	Protein conserved in bacteria
H7F27_RS14980	COG1666	GTP binding
H7F27_RS14985	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7F27_RS14985	COG0646	methionine synthase
H7F27_RS14990	COG2153	protein acetylation
H7F27_RS14995	COG0454	-acetyltransferase
H7F27_RS15000	COG2814	Major facilitator Superfamily
H7F27_RS15005	COG4948	Mandelate Racemase Muconate Lactonizing
H7F27_RS15010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F27_RS15015	COG1809	phosphosulfolactate synthase activity
H7F27_RS15020	COG2045	Belongs to the ComB family
H7F27_RS15025	COG0175	sulfate reduction
H7F27_RS15030	COG2046	Belongs to the sulfate adenylyltransferase family
H7F27_RS15035	COG0529	Catalyzes the synthesis of activated sulfate
H7F27_RS15040	COG2267	carboxylic ester hydrolase activity
H7F27_RS15045	COG1357	PFAM Pentapeptide repeats (8 copies)
H7F27_RS15050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F27_RS15055	COG1279	arginine transmembrane transporter activity
H7F27_RS15060	COG2318	DinB family
H7F27_RS15065	COG0673	inositol 2-dehydrogenase activity
H7F27_RS15070	COG1609	Transcriptional regulator
H7F27_RS15075	COG1917	Cupin 2, conserved barrel domain protein
H7F27_RS15075	COG2207	Transcriptional regulator
H7F27_RS15080	COG0534	Mate efflux family protein
H7F27_RS15085	COG1562	ergosterol biosynthetic process
H7F27_RS15090	COG2318	DinB family
H7F27_RS15095	COG0367	asparagine synthase
H7F27_RS15105	COG1404	Belongs to the peptidase S8 family
H7F27_RS15115	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7F27_RS15120	COG5337	Spore coat protein CotH
H7F27_RS15160	COG1403	HNH endonuclease
H7F27_RS15165	COG0419	ATPase involved in DNA repair
H7F27_RS15170	COG0420	3'-5' exonuclease activity
H7F27_RS15175	COG1074	ATP-dependent DNA helicase activity
H7F27_RS15180	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H7F27_RS15185	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H7F27_RS15195	COG4533	DNA binding
H7F27_RS15200	COG2814	Major facilitator Superfamily
H7F27_RS15200	COG0477	Major facilitator Superfamily
H7F27_RS15205	COG3180	Ammonia monooxygenase
H7F27_RS15210	COG1609	Transcriptional regulator
H7F27_RS15215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F27_RS15220	COG0561	phosphatase activity
H7F27_RS15225	COG0673	inositol 2-dehydrogenase activity
H7F27_RS15230	COG0738	Major facilitator superfamily
H7F27_RS15235	COG1846	Transcriptional regulator
H7F27_RS15240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7F27_RS15245	COG0681	Belongs to the peptidase S26 family
H7F27_RS15250	COG0398	Pfam SNARE associated Golgi protein
H7F27_RS15265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F27_RS15275	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS15280	COG4903	ComK protein
H7F27_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS15295	COG0723	plastoquinol--plastocyanin reductase activity
H7F27_RS15295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7F27_RS15300	COG0840	transmembrane signaling receptor activity
H7F27_RS15305	COG1268	BioY protein
H7F27_RS15310	COG0318	PFAM AMP-dependent synthetase and ligase
H7F27_RS15315	COG0183	Belongs to the thiolase family
H7F27_RS15320	COG0406	alpha-ribazole phosphatase activity
H7F27_RS15325	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H7F27_RS15330	COG0604	alcohol dehydrogenase
H7F27_RS15335	COG0456	acetyltransferase
H7F27_RS15340	COG1404	Belongs to the peptidase S8 family
H7F27_RS15345	COG0501	Belongs to the peptidase M48B family
H7F27_RS15355	COG0318	PFAM AMP-dependent synthetase and ligase
H7F27_RS15360	COG0702	epimerase
H7F27_RS15365	COG0095	Lipoate-protein ligase
H7F27_RS15370	COG1234	tRNA 3'-trailer cleavage
H7F27_RS15380	COG1301	dicarboxylic acid transport
H7F27_RS15385	COG4405	Protein conserved in bacteria
H7F27_RS15390	COG1363	Peptidase, m42
H7F27_RS15395	COG4377	Putative membrane peptidase family (DUF2324)
H7F27_RS15400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F27_RS15405	COG1511	domain protein
H7F27_RS15410	COG1309	transcriptional regulator
H7F27_RS15415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7F27_RS15420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7F27_RS15425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7F27_RS15430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F27_RS15435	COG2329	Antibiotic biosynthesis monooxygenase
H7F27_RS15445	COG3069	C4-dicarboxylate transmembrane transporter activity
H7F27_RS15450	COG1473	amidohydrolase
H7F27_RS15460	COG4473	ABC transporter
H7F27_RS15465	COG1131	(ABC) transporter
H7F27_RS15470	COG0537	adenosine 5'-monophosphoramidase activity
H7F27_RS15475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7F27_RS15490	COG4980	gas vesicle protein
H7F27_RS15495	COG1846	Transcriptional regulator
H7F27_RS15525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7F27_RS15535	COG3481	metal-dependent phosphohydrolase, HD sub domain
H7F27_RS15540	COG4717	serine-type aminopeptidase activity
H7F27_RS15545	COG0420	3'-5' exonuclease activity
H7F27_RS15550	COG1668	transmembrane transport
H7F27_RS15555	COG4152	abc transporter atp-binding protein
H7F27_RS15565	COG1024	Enoyl-CoA hydratase
H7F27_RS15575	COG0490	domain, Protein
H7F27_RS15580	COG0475	glutathione-regulated potassium exporter activity
H7F27_RS15585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7F27_RS15590	COG0561	phosphatase activity
H7F27_RS15595	COG4335	DNA alkylation repair
H7F27_RS15600	COG3679	Belongs to the UPF0342 family
H7F27_RS15605	COG4399	Belongs to the UPF0754 family
H7F27_RS15610	COG0189	ligase activity
H7F27_RS15615	COG0189	ligase activity
H7F27_RS15635	COG0702	epimerase
H7F27_RS15640	COG1132	(ABC) transporter
H7F27_RS15645	COG1132	(ABC) transporter
H7F27_RS15650	COG0589	response to stress
H7F27_RS15655	COG1757	Na H antiporter
H7F27_RS15660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F27_RS15665	COG0726	polysaccharide deacetylase
H7F27_RS15670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7F27_RS15675	COG0668	transmembrane transport
H7F27_RS15685	COG0584	glycerophosphoryl diester phosphodiesterase
H7F27_RS15690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7F27_RS15695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7F27_RS15700	COG1253	flavin adenine dinucleotide binding
H7F27_RS15705	COG0436	Aminotransferase
H7F27_RS15710	COG0789	Transcriptional regulator
H7F27_RS15715	COG1253	flavin adenine dinucleotide binding
H7F27_RS15720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F27_RS15725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7F27_RS15730	COG0204	Acyl-transferase
H7F27_RS15735	COG0667	Aldo Keto reductase
H7F27_RS15740	COG1595	DNA-templated transcription, initiation
H7F27_RS15755	COG0456	acetyltransferase
H7F27_RS15765	COG0733	neurotransmitter:sodium symporter activity
H7F27_RS15770	COG0531	amino acid
H7F27_RS15775	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS15780	COG0372	Belongs to the citrate synthase family
H7F27_RS15785	COG0583	DNA-binding transcription factor activity
H7F27_RS15790	COG0791	NLP P60 protein
H7F27_RS15790	COG1388	LysM domain
H7F27_RS15795	COG1785	Belongs to the alkaline phosphatase family
H7F27_RS15800	COG2719	SpoVR family
H7F27_RS15805	COG0668	transmembrane transport
H7F27_RS15810	COG1959	2 iron, 2 sulfur cluster binding
H7F27_RS15815	COG0791	NLP P60 protein
H7F27_RS15815	COG1388	LysM domain
H7F27_RS15830	COG0431	NADPH-dependent FMN reductase
H7F27_RS15835	COG2197	response regulator
H7F27_RS15840	COG4585	Histidine kinase
H7F27_RS15840	COG2203	Gaf domain
H7F27_RS15845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7F27_RS15850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7F27_RS15855	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7F27_RS15860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7F27_RS15865	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H7F27_RS15870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7F27_RS15880	COG3153	acetyltransferase
H7F27_RS15880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7F27_RS15885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7F27_RS15890	COG0517	IMP dehydrogenase activity
H7F27_RS15900	COG0564	pseudouridine synthase activity
H7F27_RS15905	COG3764	Sortase (surface protein transpeptidase)
H7F27_RS15910	COG4085	toxin activity
H7F27_RS15910	COG0737	Belongs to the 5'-nucleotidase family
H7F27_RS15910	COG1525	nuclease
H7F27_RS15915	COG5577	PFAM Coat F domain
H7F27_RS15935	COG1823	symporter activity
H7F27_RS15940	COG3706	GGDEF domain
H7F27_RS15945	COG1464	Belongs to the NlpA lipoprotein family
H7F27_RS15950	COG1278	Cold shock
H7F27_RS15955	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H7F27_RS15960	COG1131	(ABC) transporter
H7F27_RS15965	COG1131	(ABC) transporter
H7F27_RS15970	COG1725	Transcriptional regulator
H7F27_RS15985	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7F27_RS15990	COG2814	Major facilitator Superfamily
H7F27_RS15995	COG1566	PFAM secretion protein HlyD family protein
H7F27_RS16000	COG1846	Transcriptional regulator
H7F27_RS16005	COG2718	Belongs to the UPF0229 family
H7F27_RS16010	COG2766	serine protein kinase
H7F27_RS16015	COG1664	Polymer-forming cytoskeletal
H7F27_RS16020	COG1664	Polymer-forming cytoskeletal
H7F27_RS16025	COG0789	Transcriptional regulator
H7F27_RS16030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7F27_RS16040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7F27_RS16045	COG3382	B3 4 domain protein
H7F27_RS16055	COG1476	TRANSCRIPTIONal
H7F27_RS16065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7F27_RS16075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F27_RS16080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7F27_RS16085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7F27_RS16090	COG1116	anion transmembrane transporter activity
H7F27_RS16095	COG0753	catalase activity
H7F27_RS16105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7F27_RS16110	COG3340	Belongs to the peptidase S51 family
H7F27_RS16120	COG5577	PFAM Coat F domain
H7F27_RS16125	COG1063	alcohol dehydrogenase
H7F27_RS16135	COG4326	sporulation control protein
H7F27_RS16245	COG0735	belongs to the Fur family
H7F27_RS16250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7F27_RS16255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7F27_RS16260	COG4129	membrane
H7F27_RS16265	COG1132	(ABC) transporter
H7F27_RS16270	COG3557	Belongs to the UPF0374 family
H7F27_RS16285	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS16295	COG1194	a g-specific adenine glycosylase
H7F27_RS16305	COG4485	Bacterial membrane protein, YfhO
H7F27_RS16310	COG0463	Glycosyl transferase, family 2
H7F27_RS16315	COG0596	Alpha beta hydrolase
H7F27_RS16320	COG5658	integral membrane protein
H7F27_RS16325	COG3103	Sh3 type 3 domain protein
H7F27_RS16330	COG1476	TRANSCRIPTIONal
H7F27_RS16345	COG2814	Major facilitator Superfamily
H7F27_RS16355	COG2137	regulation of response to DNA damage stimulus
H7F27_RS16360	COG1090	epimerase
H7F27_RS16375	COG0778	Nitroreductase
H7F27_RS16380	COG0384	phenazine biosynthesis protein PhzF
H7F27_RS16385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS16390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS16395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F27_RS16400	COG0392	lysyltransferase activity
H7F27_RS16400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7F27_RS16405	COG1846	Transcriptional regulator
H7F27_RS16410	COG2814	Major facilitator Superfamily
H7F27_RS16420	COG2814	Major facilitator Superfamily
H7F27_RS16425	COG1309	transcriptional regulator
H7F27_RS16430	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
H7F27_RS16435	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7F27_RS16440	COG1695	Transcriptional regulator
H7F27_RS16445	COG0842	Transport permease protein
H7F27_RS16450	COG0842	Transport permease protein
H7F27_RS16450	COG1511	domain protein
H7F27_RS16455	COG1131	(ABC) transporter
H7F27_RS16460	COG2197	response regulator
H7F27_RS16465	COG4585	Histidine kinase
H7F27_RS16470	COG0673	inositol 2-dehydrogenase activity
H7F27_RS16475	COG1082	Xylose isomerase domain protein TIM barrel
H7F27_RS16480	COG2814	Major facilitator Superfamily
H7F27_RS16485	COG1917	Cupin 2, conserved barrel domain protein
H7F27_RS16485	COG4977	sequence-specific DNA binding
H7F27_RS16490	COG2514	catechol 2,3-dioxygenase activity
H7F27_RS16495	COG2259	Doxx family
H7F27_RS16500	COG1132	(ABC) transporter
H7F27_RS16505	COG1132	(ABC) transporter
H7F27_RS16510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS16510	COG1263	PTS System
H7F27_RS16515	COG1737	Transcriptional regulator
H7F27_RS16520	COG1486	melibiose metabolic process
H7F27_RS16525	COG4842	Belongs to the WXG100 family
H7F27_RS16550	COG1742	UPF0060 membrane protein
H7F27_RS16560	COG3284	Transcriptional regulator
H7F27_RS16570	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F27_RS16575	COG0022	dehydrogenase e1 component
H7F27_RS16580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F27_RS16590	COG4637	Psort location Cytoplasmic, score
H7F27_RS16605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7F27_RS16615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7F27_RS16620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7F27_RS16625	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H7F27_RS16630	COG0598	Magnesium transport protein CorA
H7F27_RS16635	COG2084	Dehydrogenase
H7F27_RS16640	COG0726	polysaccharide deacetylase
H7F27_RS16650	COG0535	radical SAM domain protein
H7F27_RS16655	COG0668	transmembrane transport
H7F27_RS16665	COG0387	Pfam Sodium calcium exchanger
H7F27_RS16670	COG0477	Major facilitator Superfamily
H7F27_RS16675	COG1295	ribonuclease BN
H7F27_RS16680	COG4980	gas vesicle protein
H7F27_RS16685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7F27_RS16690	COG4840	Belongs to the UPF0435 family
H7F27_RS16695	COG2814	Major facilitator Superfamily
H7F27_RS16700	COG0693	protein deglycase activity
H7F27_RS16705	COG0737	Belongs to the 5'-nucleotidase family
H7F27_RS16715	COG0778	Nitroreductase
H7F27_RS16720	COG2188	Transcriptional regulator
H7F27_RS16725	COG0366	Alpha amylase catalytic
H7F27_RS16730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS16730	COG1263	PTS System
H7F27_RS16745	COG1368	sulfuric ester hydrolase activity
H7F27_RS16750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS16750	COG1263	PTS System
H7F27_RS16755	COG0024	Methionine aminopeptidase
H7F27_RS16775	COG2258	MOSC domain
H7F27_RS16780	COG1254	Belongs to the acylphosphatase family
H7F27_RS16785	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H7F27_RS16790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F27_RS16795	COG2851	Citrate transporter
H7F27_RS16800	COG3181	Tripartite tricarboxylate transporter family receptor
H7F27_RS16805	COG4565	transcriptional regulatory protein
H7F27_RS16810	COG3290	protein histidine kinase activity
H7F27_RS16820	COG0463	Glycosyl transferase, family 2
H7F27_RS16840	COG0471	metal ion transport
H7F27_RS16845	COG3866	Pectate lyase
H7F27_RS16860	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H7F27_RS16865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS16870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS16875	COG1120	ATPase activity
H7F27_RS16880	COG2130	NADP-dependent
H7F27_RS16885	COG0456	acetyltransferase
H7F27_RS16890	COG0513	Belongs to the DEAD box helicase family
H7F27_RS16895	COG0488	(ABC) transporter
H7F27_RS16905	COG2814	Major facilitator Superfamily
H7F27_RS16910	COG0789	Transcriptional regulator
H7F27_RS16920	COG0488	(ABC) transporter
H7F27_RS16925	COG0840	transmembrane signaling receptor activity
H7F27_RS16930	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS16935	COG0531	amino acid
H7F27_RS16940	COG1011	Hydrolase
H7F27_RS16945	COG2223	nitrite transmembrane transporter activity
H7F27_RS16950	COG1442	glycosyl transferase family 8
H7F27_RS16955	COG1216	Glycosyl transferase, family 2
H7F27_RS16960	COG1442	glycosyl transferase family 8
H7F27_RS16965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F27_RS16970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7F27_RS16975	COG1368	sulfuric ester hydrolase activity
H7F27_RS16980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7F27_RS16980	COG2124	cytochrome p450
H7F27_RS16995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7F27_RS17000	COG1846	Transcriptional regulator
H7F27_RS17005	COG0670	Belongs to the BI1 family
H7F27_RS17010	COG5583	Uncharacterized small protein (DUF2292)
H7F27_RS17015	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F27_RS17025	COG0346	lactoylglutathione lyase activity
H7F27_RS17030	COG2329	Antibiotic biosynthesis monooxygenase
H7F27_RS17035	COG2323	membrane
H7F27_RS17040	COG1486	melibiose metabolic process
H7F27_RS17045	COG0395	ABC-type sugar transport system, permease component
H7F27_RS17050	COG4209	transmembrane transport
H7F27_RS17055	COG1653	transport
H7F27_RS17065	COG1874	Beta-galactosidase
H7F27_RS17070	COG2755	lipolytic protein G-D-S-L family
H7F27_RS17075	COG0667	Aldo Keto reductase
H7F27_RS17080	COG3401	FG-GAP repeat protein
H7F27_RS17085	COG3401	FG-GAP repeat protein
H7F27_RS17090	COG5578	integral membrane protein
H7F27_RS17100	COG2755	lipolytic protein G-D-S-L family
H7F27_RS17105	COG2207	Transcriptional regulator
H7F27_RS17110	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H7F27_RS17115	COG0395	ABC-type sugar transport system, permease component
H7F27_RS17120	COG1175	transmembrane transport
H7F27_RS17125	COG1653	transport
H7F27_RS17130	COG4753	response regulator
H7F27_RS17130	COG2207	Transcriptional regulator
H7F27_RS17135	COG2972	Histidine kinase
H7F27_RS17140	COG5578	integral membrane protein
H7F27_RS17150	COG0454	-acetyltransferase
H7F27_RS17155	COG3546	catalase activity
H7F27_RS17170	COG1309	transcriptional regulator
H7F27_RS17175	COG2159	amidohydrolase
H7F27_RS17180	COG0702	epimerase
H7F27_RS17185	COG3631	Ketosteroid isomerase-related protein
H7F27_RS17190	COG1309	transcriptional regulator
H7F27_RS17200	COG0217	transcriptional regulatory protein
H7F27_RS17210	COG0457	Tetratricopeptide repeat
H7F27_RS17215	COG3391	amine dehydrogenase activity
H7F27_RS17220	COG3586	endonuclease activity
H7F27_RS17230	COG5444	nuclease activity
H7F27_RS17290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7F27_RS17295	COG1597	lipid kinase activity
H7F27_RS17300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7F27_RS17305	COG1309	transcriptional regulator
H7F27_RS17310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7F27_RS17315	COG0154	amidase activity
H7F27_RS17320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7F27_RS17325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F27_RS17330	COG1285	pathogenesis
H7F27_RS17335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7F27_RS17340	COG4851	CamS sex pheromone cAM373 precursor
H7F27_RS17345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7F27_RS17350	COG0210	DNA helicase
H7F27_RS17355	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H7F27_RS17360	COG0069	glutamate synthase activity
H7F27_RS17365	COG4496	protein, YerC YecD
H7F27_RS17370	COG1470	cell adhesion involved in biofilm formation
H7F27_RS17375	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7F27_RS17385	COG0531	amino acid
H7F27_RS17395	COG0151	Belongs to the GarS family
H7F27_RS17400	COG0138	bifunctional purine biosynthesis protein purh
H7F27_RS17405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7F27_RS17410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7F27_RS17415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7F27_RS17420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7F27_RS17425	COG0047	phosphoribosylformylglycinamidine synthase activity
H7F27_RS17430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7F27_RS17435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7F27_RS17440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7F27_RS17445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7F27_RS17450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7F27_RS17460	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H7F27_RS17470	COG3064	Membrane
H7F27_RS17475	COG2252	PERMEase
H7F27_RS17495	COG0519	Catalyzes the synthesis of GMP from XMP
H7F27_RS17495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7F27_RS17500	COG1305	Transglutaminase-like
H7F27_RS17505	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
H7F27_RS17510	COG0714	Associated with various cellular activities
H7F27_RS17515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7F27_RS17520	COG1113	amino acid transport
H7F27_RS17525	COG2132	Multicopper oxidase
H7F27_RS17535	COG2267	carboxylic ester hydrolase activity
H7F27_RS17550	COG0823	Involved in the tonB-independent uptake of proteins
H7F27_RS17555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7F27_RS17560	COG1063	alcohol dehydrogenase
H7F27_RS17565	COG2814	Major facilitator Superfamily
H7F27_RS17575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F27_RS17580	COG2211	Major facilitator Superfamily
H7F27_RS17585	COG1063	alcohol dehydrogenase
H7F27_RS17590	COG0457	Tetratricopeptide repeat
H7F27_RS17600	COG3409	Peptidoglycan-binding domain 1 protein
H7F27_RS17615	COG1266	CAAX protease self-immunity
H7F27_RS17625	COG0805	protein transport
H7F27_RS17630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7F27_RS17635	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H7F27_RS17640	COG0315	cyclic pyranopterin monophosphate synthase activity
H7F27_RS17645	COG0488	(ABC) transporter
H7F27_RS17650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7F27_RS17655	COG0456	acetyltransferase
H7F27_RS17660	COG1214	PFAM Peptidase M22, glycoprotease
H7F27_RS17665	COG0802	atpase or kinase
H7F27_RS17670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7F27_RS17715	COG4124	Belongs to the glycosyl hydrolase 26 family
H7F27_RS17720	COG1482	cell wall glycoprotein biosynthetic process
H7F27_RS17725	COG1940	carbohydrate kinase activity
H7F27_RS17730	COG2188	Transcriptional regulator
H7F27_RS17735	COG2723	6-phospho-beta-galactosidase activity
H7F27_RS17740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F27_RS17745	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7F27_RS17750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F27_RS17755	COG2814	Major facilitator Superfamily
H7F27_RS17760	COG1388	LysM domain
H7F27_RS17765	COG1078	dGTPase activity
H7F27_RS17780	COG1785	Belongs to the alkaline phosphatase family
H7F27_RS17795	COG1819	glycosyl
H7F27_RS17800	COG3858	chitin binding
H7F27_RS17800	COG1388	LysM domain
H7F27_RS17805	COG1802	Transcriptional regulator
H7F27_RS17810	COG0730	response to heat
H7F27_RS17815	COG2814	Major facilitator Superfamily
H7F27_RS17825	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H7F27_RS17830	COG1396	sequence-specific DNA binding
H7F27_RS17835	COG1846	Transcriptional regulator
H7F27_RS17840	COG0778	Nitroreductase
H7F27_RS17845	COG2409	Drug exporters of the RND superfamily
H7F27_RS17845	COG1033	growth of symbiont in host cell
H7F27_RS17850	COG1846	Transcriptional regulator
H7F27_RS17855	COG2318	DinB family
H7F27_RS17860	COG1113	amino acid transport
H7F27_RS17865	COG0488	(ABC) transporter
H7F27_RS17870	COG1082	Xylose isomerase domain protein TIM barrel
H7F27_RS17875	COG2814	Major facilitator Superfamily
H7F27_RS17880	COG1609	Transcriptional regulator
H7F27_RS17885	COG0673	inositol 2-dehydrogenase activity
H7F27_RS17895	COG0456	acetyltransferase
H7F27_RS17905	COG1309	transcriptional regulator
H7F27_RS17910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F27_RS17915	COG2323	membrane
H7F27_RS17920	COG1522	sequence-specific DNA binding
H7F27_RS17925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7F27_RS17930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F27_RS17935	COG0596	Alpha beta hydrolase
H7F27_RS17940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F27_RS17945	COG0697	spore germination
H7F27_RS17950	COG2030	dehydratase
H7F27_RS17955	COG1482	cell wall glycoprotein biosynthetic process
H7F27_RS17960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F27_RS17960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F27_RS17960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F27_RS17965	COG3711	transcriptional antiterminator
H7F27_RS17965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F27_RS17970	COG0456	acetyltransferase
H7F27_RS17980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F27_RS17985	COG1733	regulation of RNA biosynthetic process
H7F27_RS17990	COG3545	Serine hydrolase
H7F27_RS18000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F27_RS18005	COG0697	spore germination
H7F27_RS18020	COG0693	protein deglycase activity
H7F27_RS18035	COG2808	Putative FMN-binding domain
H7F27_RS18040	COG0456	acetyltransferase
H7F27_RS18045	COG1846	Transcriptional regulator
H7F27_RS18050	COG2364	Membrane
H7F27_RS18065	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
H7F27_RS18085	COG0346	lactoylglutathione lyase activity
H7F27_RS18090	COG2315	Protein conserved in bacteria
H7F27_RS18095	COG1329	Transcriptional regulator
H7F27_RS18105	COG1278	Cold shock
H7F27_RS18110	COG1278	Cold shock
H7F27_RS18115	COG3239	Fatty acid desaturase
H7F27_RS18120	COG1476	TRANSCRIPTIONal
H7F27_RS18145	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7F27_RS18175	COG2856	Zn peptidase
H7F27_RS18210	COG1191	sigma factor activity
H7F27_RS18275	COG3091	SprT-like family
H7F27_RS18285	COG2183	response to ionizing radiation
H7F27_RS18290	COG1846	Transcriptional regulator
H7F27_RS18295	COG1673	EVE domain
H7F27_RS18305	COG2208	phosphoserine phosphatase activity
H7F27_RS18310	COG1191	sigma factor activity
H7F27_RS18315	COG2172	sigma factor antagonist activity
H7F27_RS18320	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F27_RS18325	COG2208	phosphoserine phosphatase activity
H7F27_RS18330	COG2172	sigma factor antagonist activity
H7F27_RS18335	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F27_RS18340	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F27_RS18345	COG2337	Toxic component of a toxin-antitoxin (TA) module
H7F27_RS18350	COG0864	Transcriptional regulator
H7F27_RS18355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7F27_RS18360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7F27_RS18365	COG0736	holo-[acyl-carrier-protein] synthase activity
H7F27_RS18370	COG0705	Rhomboid family
H7F27_RS18375	COG3428	Bacterial PH domain
H7F27_RS18380	COG3402	PFAM membrane-flanked domain
H7F27_RS18385	COG0513	Belongs to the DEAD box helicase family
H7F27_RS18390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7F27_RS18395	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7F27_RS18400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F27_RS18405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7F27_RS18420	COG1960	acyl-CoA dehydrogenase activity
H7F27_RS18430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H7F27_RS18435	COG1131	(ABC) transporter
H7F27_RS18440	COG1301	dicarboxylic acid transport
H7F27_RS18445	COG0628	permease
H7F27_RS18450	COG1301	dicarboxylic acid transport
H7F27_RS18455	COG4565	transcriptional regulatory protein
H7F27_RS18460	COG3290	protein histidine kinase activity
H7F27_RS18465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7F27_RS18470	COG3546	catalase activity
H7F27_RS18480	COG2329	Antibiotic biosynthesis monooxygenase
H7F27_RS18485	COG0662	Cupin 2, conserved barrel domain protein
H7F27_RS18490	COG3729	General stress protein
H7F27_RS18495	COG2217	Heavy metal translocating P-type atpase
H7F27_RS18500	COG4876	unkown
H7F27_RS18505	COG2261	transglycosylase associated protein
H7F27_RS18510	COG1914	H( )-stimulated, divalent metal cation uptake system
H7F27_RS18520	COG0028	Belongs to the TPP enzyme family
H7F27_RS18525	COG0494	nUDIX hydrolase
H7F27_RS18530	COG0531	amino acid
H7F27_RS18540	COG1215	transferase activity, transferring glycosyl groups
H7F27_RS18545	COG5298	Protein conserved in bacteria
H7F27_RS18550	COG3706	GGDEF domain
H7F27_RS18555	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7F27_RS18560	COG0551	DNA topoisomerase type I activity
H7F27_RS18560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7F27_RS18565	COG1522	sequence-specific DNA binding
H7F27_RS18570	COG2814	Major facilitator Superfamily
H7F27_RS18575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7F27_RS18585	COG3871	stress protein (general stress protein 26)
H7F27_RS18590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F27_RS18595	COG1917	Cupin 2, conserved barrel domain protein
H7F27_RS18600	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS18605	COG2226	methyltransferase
H7F27_RS18610	COG0318	PFAM AMP-dependent synthetase and ligase
H7F27_RS18615	COG3711	transcriptional antiterminator
H7F27_RS18620	COG4989	oxidoreductase activity
H7F27_RS18625	COG0768	penicillin binding
H7F27_RS18630	COG2329	Antibiotic biosynthesis monooxygenase
H7F27_RS18640	COG2755	lipolytic protein G-D-S-L family
H7F27_RS18645	COG1414	Transcriptional regulator
H7F27_RS18650	COG1984	allophanate hydrolase subunit 2
H7F27_RS18655	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H7F27_RS18660	COG4336	lyase activity
H7F27_RS18665	COG1914	H( )-stimulated, divalent metal cation uptake system
H7F27_RS18670	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H7F27_RS18675	COG0561	phosphatase activity
H7F27_RS18685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7F27_RS18695	COG0473	3-isopropylmalate dehydrogenase activity
H7F27_RS18700	COG0246	Mannitol dehydrogenase
H7F27_RS18715	COG1349	DNA-binding transcription factor activity
H7F27_RS18720	COG1276	copper resistance
H7F27_RS18720	COG2372	response to copper ion
H7F27_RS18725	COG4549	nuclear export factor GLE1
H7F27_RS18730	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS18735	COG4975	Glucose uptake
H7F27_RS18740	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS18745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7F27_RS18750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F27_RS18755	COG0640	Transcriptional regulator
H7F27_RS18760	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7F27_RS18765	COG0778	Nitroreductase
H7F27_RS18770	COG1309	transcriptional regulator
H7F27_RS18775	COG2814	Major facilitator Superfamily
H7F27_RS18780	COG4607	ABC-type enterochelin transport system periplasmic component
H7F27_RS18785	COG4604	ABC transporter, ATP-binding protein
H7F27_RS18790	COG4605	iron ion homeostasis
H7F27_RS18795	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS18800	COG0527	aspartate kinase activity
H7F27_RS18820	COG0457	Tetratricopeptide repeat
H7F27_RS18825	COG3850	Histidine kinase
H7F27_RS18825	COG5002	protein histidine kinase activity
H7F27_RS18830	COG0745	RESPONSE REGULATOR receiver
H7F27_RS18835	COG0577	efflux transmembrane transporter activity
H7F27_RS18840	COG1136	(ABC) transporter
H7F27_RS18845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H7F27_RS18855	COG0697	spore germination
H7F27_RS18865	COG5434	Belongs to the glycosyl hydrolase 28 family
H7F27_RS18870	COG3104	oligopeptide transport
H7F27_RS18875	COG0596	Alpha beta hydrolase
H7F27_RS18890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7F27_RS18895	COG0163	prenyltransferase activity
H7F27_RS18900	COG0583	DNA-binding transcription factor activity
H7F27_RS18905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F27_RS18910	COG0765	amino acid transport
H7F27_RS18915	COG1126	abc transporter atp-binding protein
H7F27_RS18920	COG2364	Membrane
H7F27_RS18930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F27_RS18935	COG0697	spore germination
H7F27_RS18945	COG2814	Major facilitator Superfamily
H7F27_RS18950	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H7F27_RS18955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS18960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS18965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F27_RS18970	COG1733	regulation of RNA biosynthetic process
H7F27_RS18975	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H7F27_RS18980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7F27_RS18985	COG3290	protein histidine kinase activity
H7F27_RS18985	COG0840	transmembrane signaling receptor activity
H7F27_RS18990	COG3209	COG3209 Rhs family protein
H7F27_RS19000	COG2723	6-phospho-beta-galactosidase activity
H7F27_RS19005	COG3842	ATPase activity
H7F27_RS19015	COG1714	RDD family
H7F27_RS19020	COG1063	alcohol dehydrogenase
H7F27_RS19025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F27_RS19030	COG0765	amino acid transport
H7F27_RS19035	COG0523	cobalamin synthesis protein
H7F27_RS19045	COG1376	ErfK ybiS ycfS ynhG family protein
H7F27_RS19050	COG1469	GTP cyclohydrolase I activity
H7F27_RS19055	COG2223	nitrite transmembrane transporter activity
H7F27_RS19060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F27_RS19065	COG0243	molybdopterin cofactor binding
H7F27_RS19070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F27_RS19075	COG2146	nitrite reductase [NAD(P)H] activity
H7F27_RS19080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7F27_RS19080	COG1587	Uroporphyrinogen-III synthase
H7F27_RS19085	COG0492	ferredoxin-NADP+ reductase activity
H7F27_RS19090	COG0701	Predicted permease
H7F27_RS19095	COG3689	TIGRFAM TIGR03943 family protein
H7F27_RS19100	COG2508	Transcriptional regulator
H7F27_RS19105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F27_RS19110	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS19115	COG0506	proline dehydrogenase activity
H7F27_RS19120	COG3541	Predicted nucleotidyltransferase
H7F27_RS19125	COG3458	cephalosporin-C deacetylase activity
H7F27_RS19130	COG0583	DNA-binding transcription factor activity
H7F27_RS19135	COG2226	methyltransferase
H7F27_RS19145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7F27_RS19155	COG1660	Displays ATPase and GTPase activities
H7F27_RS19160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7F27_RS19165	COG3665	Urea carboxylase-associated protein
H7F27_RS19170	COG1113	amino acid transport
H7F27_RS19175	COG3403	YqcI/YcgG family
H7F27_RS19180	COG1280	lysine exporter protein (LysE YggA)
H7F27_RS19185	COG1846	Transcriptional regulator
H7F27_RS19190	COG2814	Major facilitator Superfamily
H7F27_RS19195	COG1620	l-lactate permease
H7F27_RS19200	COG0039	L-malate dehydrogenase activity
H7F27_RS19205	COG0366	Alpha amylase catalytic
H7F27_RS19215	COG1288	antiporter activity
H7F27_RS19220	COG1473	amidohydrolase
H7F27_RS19225	COG2113	Glycine betaine
H7F27_RS19230	COG4176	ABC-type proline glycine betaine transport system permease component
H7F27_RS19235	COG0517	IMP dehydrogenase activity
H7F27_RS19235	COG4175	Glycine betaine
H7F27_RS19240	COG0640	Transcriptional regulator
H7F27_RS19245	COG2814	Major facilitator Superfamily
H7F27_RS19250	COG0477	Major facilitator Superfamily
H7F27_RS19255	COG3853	Toxic anion resistance protein (TelA)
H7F27_RS19270	COG1358	cellular component organization or biogenesis
H7F27_RS19285	COG0861	Integral membrane protein TerC family
H7F27_RS19290	COG2310	stress, protein
H7F27_RS19295	COG2310	stress, protein
H7F27_RS19300	COG2310	stress, protein
H7F27_RS19305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F27_RS19310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7F27_RS19315	COG1121	(ABC) transporter
H7F27_RS19320	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7F27_RS19325	COG0366	Alpha amylase catalytic
H7F27_RS19330	COG1028	Short-chain dehydrogenase reductase Sdr
H7F27_RS19335	COG0457	Tetratricopeptide repeat
H7F27_RS19340	COG1876	peptidase activity
H7F27_RS19345	COG1595	DNA-templated transcription, initiation
H7F27_RS19350	COG1595	DNA-templated transcription, initiation
H7F27_RS19360	COG0667	Aldo Keto reductase
H7F27_RS19365	COG1668	transmembrane transport
H7F27_RS19370	COG4555	ABC transporter
H7F27_RS19375	COG3279	Response regulator of the LytR AlgR family
H7F27_RS19380	COG3290	protein histidine kinase activity
H7F27_RS19385	COG3012	SEC-C Motif Domain Protein
H7F27_RS19385	COG1405	negative regulation of cell septum assembly
H7F27_RS19390	COG1714	RDD family
H7F27_RS19395	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7F27_RS19400	COG0252	asparaginase activity
H7F27_RS19405	COG1309	transcriptional regulator
H7F27_RS19410	COG0477	Major facilitator Superfamily
H7F27_RS19415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7F27_RS19420	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H7F27_RS19425	COG0805	protein transport
H7F27_RS19430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7F27_RS19435	COG3540	Alkaline phosphatase
H7F27_RS19445	COG2304	oxidoreductase activity
H7F27_RS19450	COG3773	Cell wall hydrolase
H7F27_RS19470	COG1131	(ABC) transporter
H7F27_RS19475	COG2205	protein histidine kinase activity
H7F27_RS19480	COG0745	RESPONSE REGULATOR receiver
H7F27_RS19490	COG3173	Aminoglycoside phosphotransferase
H7F27_RS19495	COG2721	sulfolactate sulfo-lyase activity
H7F27_RS19500	COG2186	Transcriptional regulator
H7F27_RS19505	COG4948	Mandelate Racemase Muconate Lactonizing
H7F27_RS19510	COG2271	Major facilitator Superfamily
H7F27_RS19515	COG1012	belongs to the aldehyde dehydrogenase family
H7F27_RS19520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7F27_RS19525	COG0784	Response regulator, receiver
H7F27_RS19530	COG4191	Histidine kinase
H7F27_RS19535	COG2066	Belongs to the glutaminase family
H7F27_RS19540	COG1115	amino acid carrier protein
H7F27_RS19545	COG2040	homocysteine
H7F27_RS19550	COG0833	amino acid
H7F27_RS19555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F27_RS19565	COG2188	Transcriptional regulator
H7F27_RS19570	COG0363	glucosamine-6-phosphate deaminase activity
H7F27_RS19575	COG2190	(PTS) system
H7F27_RS19575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS19575	COG1263	PTS System
H7F27_RS19580	COG1301	dicarboxylic acid transport
H7F27_RS19585	COG1054	Belongs to the UPF0176 family
H7F27_RS19590	COG2207	Transcriptional regulator
H7F27_RS19595	COG2312	Erythromycin esterase
H7F27_RS19605	COG0688	phosphatidylethanolamine metabolic process
H7F27_RS19610	COG0586	Pfam SNARE associated Golgi protein
H7F27_RS19615	COG1183	phosphatidylcholine synthase activity
H7F27_RS19620	COG0596	Alpha beta hydrolase
H7F27_RS19630	COG3591	Belongs to the peptidase S1B family
H7F27_RS19635	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7F27_RS19640	COG0371	Dehydrogenase
H7F27_RS19655	COG2271	Major facilitator Superfamily
H7F27_RS19660	COG1846	Transcriptional regulator
H7F27_RS19660	COG0456	acetyltransferase
H7F27_RS19670	COG2271	Major facilitator Superfamily
H7F27_RS19675	COG0584	glycerophosphoryl diester phosphodiesterase
H7F27_RS19680	COG0531	amino acid
H7F27_RS19690	COG2124	cytochrome p450
H7F27_RS19695	COG2602	Beta-lactamase
H7F27_RS19710	COG1113	amino acid transport
H7F27_RS19725	COG0515	serine threonine protein kinase
H7F27_RS19735	COG0642	Histidine kinase
H7F27_RS19740	COG0745	RESPONSE REGULATOR receiver
H7F27_RS19745	COG0596	Alpha beta hydrolase
H7F27_RS19755	COG1413	lyase activity
H7F27_RS19760	COG2814	Major facilitator Superfamily
H7F27_RS19765	COG0640	Transcriptional regulator
H7F27_RS19770	COG5609	conserved protein (DUF2294)
H7F27_RS19780	COG0288	reversible hydration of carbon dioxide
H7F27_RS19785	COG3002	Belongs to the UPF0753 family
H7F27_RS19790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7F27_RS19800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7F27_RS19805	COG4856	YbbR-like protein
H7F27_RS19810	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H7F27_RS19815	COG5662	AntiSigma factor
H7F27_RS19820	COG1595	DNA-templated transcription, initiation
H7F27_RS19850	COG1683	Conserved Protein
H7F27_RS19855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F27_RS19860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H7F27_RS19865	COG1737	Transcriptional regulator
H7F27_RS19870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F27_RS19870	COG1263	PTS System
H7F27_RS19875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7F27_RS19880	COG1472	Belongs to the glycosyl hydrolase 3 family
H7F27_RS19885	COG3876	Protein conserved in bacteria
H7F27_RS19890	COG2207	Transcriptional regulator
H7F27_RS19890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F27_RS19895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F27_RS19900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS19905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F27_RS19910	COG2819	hydrolase of the alpha beta superfamily
H7F27_RS19915	COG0385	Bile acid
H7F27_RS19920	COG0659	secondary active sulfate transmembrane transporter activity
H7F27_RS20000	COG0726	polysaccharide deacetylase
H7F27_RS20005	COG2194	sulfuric ester hydrolase activity
H7F27_RS20015	COG0489	protein tyrosine kinase activity
H7F27_RS20020	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F27_RS20030	COG2226	methyltransferase
H7F27_RS20040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7F27_RS20045	COG0101	tRNA pseudouridine synthase activity
H7F27_RS20050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H7F27_RS20055	COG1122	ATPase activity
H7F27_RS20060	COG1122	ATPase activity
H7F27_RS20065	COG0203	ribosomal protein L17
H7F27_RS20070	COG0202	RNA polymerase activity
H7F27_RS20075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7F27_RS20085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7F27_RS20095	COG0024	Methionine aminopeptidase
H7F27_RS20100	COG0563	adenylate kinase activity
H7F27_RS20105	COG0201	protein transport
H7F27_RS20110	COG0200	Binds to the 23S rRNA
H7F27_RS20125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7F27_RS20130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7F27_RS20135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7F27_RS20145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7F27_RS20155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7F27_RS20160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7F27_RS20170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7F27_RS20190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7F27_RS20205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7F27_RS20215	COG0596	Alpha beta hydrolase
H7F27_RS20220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7F27_RS20225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7F27_RS20230	COG0049	tRNA binding
H7F27_RS20240	COG1358	cellular component organization or biogenesis
H7F27_RS20245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7F27_RS20250	COG0085	RNA polymerase activity
H7F27_RS20255	COG2813	Specifically methylates the guanine in position
H7F27_RS20270	COG0081	regulation of translation
H7F27_RS20280	COG0250	Participates in transcription elongation, termination and antitermination
H7F27_RS20285	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7F27_RS20295	COG1595	DNA-templated transcription, initiation
H7F27_RS20300	COG3688	RNA-binding protein containing a PIN domain
H7F27_RS20305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7F27_RS20310	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H7F27_RS20315	COG0215	cysteine-tRNA ligase activity
H7F27_RS20320	COG1045	serine acetyltransferase
H7F27_RS20325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7F27_RS20330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7F27_RS20335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7F27_RS20340	COG4956	integral membrane protein (PIN domain superfamily)
H7F27_RS20345	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H7F27_RS20350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7F27_RS20355	COG0542	response to heat
H7F27_RS20360	COG3869	Catalyzes the specific phosphorylation of arginine residues in
H7F27_RS20365	COG3880	PFAM UvrB UvrC protein
H7F27_RS20370	COG4463	regulation of RNA biosynthetic process
H7F27_RS20450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7F27_RS20455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7F27_RS20460	COG1396	sequence-specific DNA binding
H7F27_RS20465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7F27_RS20470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7F27_RS20475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7F27_RS20480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F27_RS20485	COG0512	Glutamine amidotransferase of anthranilate synthase
H7F27_RS20490	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7F27_RS20495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F27_RS20500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7F27_RS20505	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7F27_RS20510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H7F27_RS20515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7F27_RS20520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7F27_RS20525	COG0037	tRNA processing
H7F27_RS20530	COG0515	serine threonine protein kinase
H7F27_RS20535	COG2304	oxidoreductase activity
H7F27_RS20540	COG2208	phosphoserine phosphatase activity
H7F27_RS20555	COG1098	S1 RNA binding domain
H7F27_RS20560	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7F27_RS20575	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H7F27_RS20580	COG3956	TIGRFAM MazG family protein
H7F27_RS20585	COG2244	polysaccharide biosynthetic process
H7F27_RS20590	COG2002	toxin-antitoxin pair type II binding
H7F27_RS20595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7F27_RS20605	COG0193	aminoacyl-tRNA hydrolase activity
H7F27_RS20610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7F27_RS20615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7F27_RS20620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7F27_RS20625	COG2088	sporulation resulting in formation of a cellular spore
H7F27_RS20630	COG0251	oxidation-reduction process
H7F27_RS20635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7F27_RS20640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7F27_RS20650	COG4466	Protein conserved in bacteria
H7F27_RS20660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7F27_RS20665	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H7F27_RS20670	COG3583	domain protein
H7F27_RS20670	COG3584	3D domain protein
H7F27_RS20675	COG0084	hydrolase, TatD family'
H7F27_RS20680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F27_RS20680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F27_RS20685	COG2002	toxin-antitoxin pair type II binding
H7F27_RS20690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7F27_RS20695	COG2827	Endonuclease containing a URI domain
H7F27_RS20700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7F27_RS20710	COG1774	PSP1 C-terminal conserved region
H7F27_RS20715	COG0470	DNA polymerase III