locus-tag	class	description
H4O14_RS00010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4O14_RS00025	COG0187	DNA topoisomerase II activity
H4O14_RS00035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4O14_RS00040	COG2501	S4 domain
H4O14_RS00045	COG0592	DNA-directed DNA polymerase activity
H4O14_RS00050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4O14_RS00060	COG0594	ribonuclease P activity
H4O14_RS00065	COG0706	membrane insertase activity
H4O14_RS00070	COG1847	R3H domain protein
H4O14_RS00075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4O14_RS00080	COG0445	tRNA wobble uridine modification
H4O14_RS00085	COG0357	Ribosomal RNA small subunit methyltransferase G
H4O14_RS00095	COG1192	Involved in chromosome partitioning
H4O14_RS00100	COG1475	DNA binding
H4O14_RS00105	COG1811	Na channel or pump
H4O14_RS00115	COG0668	transmembrane transport
H4O14_RS00120	COG4481	Protein conserved in bacteria
H4O14_RS00125	COG0012	GTP binding
H4O14_RS00130	COG0360	Binds together with S18 to 16S ribosomal RNA
H4O14_RS00135	COG0629	single-stranded DNA binding
H4O14_RS00145	COG4241	membrane
H4O14_RS00150	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H4O14_RS00155	COG0359	binds to the 23S rRNA
H4O14_RS00160	COG0305	Participates in initiation and elongation during chromosome replication
H4O14_RS00165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4O14_RS00175	COG0739	heme binding
H4O14_RS00180	COG0745	RESPONSE REGULATOR receiver
H4O14_RS00185	COG5002	protein histidine kinase activity
H4O14_RS00195	COG4853	Protein conserved in bacteria
H4O14_RS00200	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H4O14_RS00205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_RS00290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4O14_RS00305	COG0577	efflux transmembrane transporter activity
H4O14_RS00310	COG1136	(ABC) transporter
H4O14_RS00315	COG2205	protein histidine kinase activity
H4O14_RS00320	COG0745	RESPONSE REGULATOR receiver
H4O14_RS00325	COG2814	Major facilitator Superfamily
H4O14_RS00330	COG1846	Transcriptional regulator
H4O14_RS00335	COG0326	Molecular chaperone. Has ATPase activity
H4O14_RS00340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4O14_RS00350	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4O14_RS00355	COG3842	ATPase activity
H4O14_RS00365	COG2195	Cleaves the N-terminal amino acid of tripeptides
H4O14_RS00375	COG2094	Belongs to the DNA glycosylase MPG family
H4O14_RS00390	COG5002	protein histidine kinase activity
H4O14_RS00400	COG4842	Belongs to the WXG100 family
H4O14_RS00405	COG5417	Belongs to the EsaB family
H4O14_RS00410	COG4499	WXG100 protein secretion system (Wss), protein YukC
H4O14_RS00415	COG0433	COG0433 Predicted ATPase
H4O14_RS00415	COG1674	ftsk spoiiie
H4O14_RS00420	COG1511	domain protein
H4O14_RS00430	COG1187	pseudouridine synthase activity
H4O14_RS00470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H4O14_RS00475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_RS00495	COG4895	conserved protein (DUF2196)
H4O14_RS00515	COG3173	Aminoglycoside phosphotransferase
H4O14_RS00520	COG0488	(ABC) transporter
H4O14_RS00530	COG0551	DNA topoisomerase type I activity
H4O14_RS00530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4O14_RS00540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4O14_RS00545	COG1845	cytochrome c oxidase, subunit III
H4O14_RS00550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4O14_RS00565	COG3314	Sporulation integral membrane protein YlbJ
H4O14_RS00570	COG0778	Nitroreductase
H4O14_RS00580	COG1522	sequence-specific DNA binding
H4O14_RS00590	COG2059	Chromate
H4O14_RS00595	COG2059	Chromate
H4O14_RS00600	COG1404	Belongs to the peptidase S8 family
H4O14_RS00610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_RS00615	COG0351	phosphomethylpyrimidine kinase
H4O14_RS00620	COG1309	transcriptional regulator
H4O14_RS00640	COG1216	Glycosyl transferase, family 2
H4O14_RS00645	COG0300	oxidoreductase activity
H4O14_RS00675	COG2363	Small membrane protein
H4O14_RS00695	COG3253	May function as heme-dependent peroxidase
H4O14_RS00700	COG0280	phosphate acetyltransferase
H4O14_RS00705	COG1266	CAAX protease self-immunity
H4O14_RS00720	COG4844	belongs to the
H4O14_RS00725	COG1078	dGTPase activity
H4O14_RS00730	COG3465	dGTPase activity
H4O14_RS00740	COG1994	Peptidase M50
H4O14_RS00750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_RS00755	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H4O14_RS00760	COG0010	Belongs to the arginase family
H4O14_RS00765	COG4506	Protein conserved in bacteria
H4O14_RS00770	COG0018	arginyl-trna synthetase
H4O14_RS00780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4O14_RS00785	COG2181	nitrate reductase activity
H4O14_RS00785	COG0247	lactate metabolic process
H4O14_RS00790	COG0183	Belongs to the thiolase family
H4O14_RS00795	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_RS00800	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS00805	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS00815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_RS00815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_RS00815	COG1703	isobutyryl-CoA mutase activity
H4O14_RS00825	COG2310	stress, protein
H4O14_RS00830	COG2310	stress, protein
H4O14_RS00865	COG3853	Toxic anion resistance protein (TelA)
H4O14_RS00880	COG4821	SIS domain
H4O14_RS00885	COG2204	response regulator
H4O14_RS00890	COG0191	fructose-bisphosphate aldolase activity
H4O14_RS00895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4O14_RS00900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4O14_RS00905	COG1494	fructose-1,6-bisphosphatase
H4O14_RS00910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H4O14_RS00915	COG0254	rRNA binding
H4O14_RS00920	COG1435	thymidine kinase activity
H4O14_RS00930	COG0789	Transcriptional regulator
H4O14_RS00935	COG0346	lactoylglutathione lyase activity
H4O14_RS00940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4O14_RS00945	COG2890	protein-(glutamine-N5) methyltransferase activity
H4O14_RS00960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H4O14_RS00965	COG0009	L-threonylcarbamoyladenylate synthase
H4O14_RS00970	COG1971	Probably functions as a manganese efflux pump
H4O14_RS00980	COG0698	ribose 5-phosphate isomerase
H4O14_RS00990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4O14_RS00995	COG1968	undecaprenyl-diphosphatase activity
H4O14_RS01000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H4O14_RS01005	COG1404	Belongs to the peptidase S8 family
H4O14_RS01020	COG0356	it plays a direct role in the translocation of protons across the membrane
H4O14_RS01035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4O14_RS01040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H4O14_RS01045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H4O14_RS01050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4O14_RS01055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H4O14_RS01060	COG0477	Major facilitator Superfamily
H4O14_RS01070	COG2972	Histidine kinase
H4O14_RS01075	COG4753	response regulator
H4O14_RS01075	COG2207	Transcriptional regulator
H4O14_RS01080	COG4213	ABC transporter substrate-binding protein
H4O14_RS01085	COG1129	ABC transporter
H4O14_RS01090	COG4214	carbohydrate transport
H4O14_RS01095	COG0840	transmembrane signaling receptor activity
H4O14_RS01105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O14_RS01105	COG0723	plastoquinol--plastocyanin reductase activity
H4O14_RS01110	COG0673	inositol 2-dehydrogenase activity
H4O14_RS01120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4O14_RS01125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4O14_RS01130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4O14_RS01150	COG0839	Belongs to the complex I subunit 6 family
H4O14_RS01155	COG0713	ATP synthesis coupled electron transport
H4O14_RS01160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4O14_RS01170	COG1007	ATP synthesis coupled electron transport
H4O14_RS01175	COG4836	Membrane
H4O14_RS01185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4O14_RS01195	COG2385	sporulation resulting in formation of a cellular spore
H4O14_RS01205	COG1247	-acetyltransferase
H4O14_RS01215	COG0739	heme binding
H4O14_RS01225	COG1609	Transcriptional regulator
H4O14_RS01230	COG1077	Cell shape determining protein MreB Mrl
H4O14_RS01235	COG4786	Flagellar basal body rod
H4O14_RS01240	COG4786	Flagellar basal body rod
H4O14_RS01280	COG0629	single-stranded DNA binding
H4O14_RS01290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H4O14_RS01295	COG4715	Zinc finger, swim domain protein
H4O14_RS01305	COG3944	biosynthesis protein
H4O14_RS01310	COG0489	protein tyrosine kinase activity
H4O14_RS01315	COG4464	protein tyrosine phosphatase activity
H4O14_RS01320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4O14_RS01325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4O14_RS01330	COG2327	Polysaccharide pyruvyl transferase
H4O14_RS01345	COG1216	Glycosyl transferase, family 2
H4O14_RS01345	COG1442	glycosyl transferase family 8
H4O14_RS01360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4O14_RS01370	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H4O14_RS01370	COG0662	Cupin 2, conserved barrel domain protein
H4O14_RS01375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4O14_RS01380	COG1482	cell wall glycoprotein biosynthetic process
H4O14_RS01385	COG1737	Transcriptional regulator
H4O14_RS01390	COG1486	melibiose metabolic process
H4O14_RS01395	COG1263	PTS System
H4O14_RS01395	COG2190	(PTS) system
H4O14_RS01395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_RS01425	COG0653	protein targeting
H4O14_RS01430	COG1316	TRANSCRIPTIONal
H4O14_RS01440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_RS01455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4O14_RS01460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4O14_RS01465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H4O14_RS01485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H4O14_RS01490	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4O14_RS01500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4O14_RS01505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4O14_RS01520	COG0673	inositol 2-dehydrogenase activity
H4O14_RS01540	COG2247	cell wall binding repeat
H4O14_RS01540	COG2385	sporulation resulting in formation of a cellular spore
H4O14_RS01550	COG1316	TRANSCRIPTIONal
H4O14_RS01555	COG1739	Uncharacterized protein family UPF0029
H4O14_RS01560	COG4585	Histidine kinase
H4O14_RS01565	COG2197	response regulator
H4O14_RS01570	COG1307	EDD domain protein, DegV family
H4O14_RS01580	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H4O14_RS01590	COG1040	competence protein
H4O14_RS01605	COG3418	PFAM FlgN family protein
H4O14_RS01610	COG1256	bacterial-type flagellum assembly
H4O14_RS01610	COG4786	Flagellar basal body rod
H4O14_RS01615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4O14_RS01625	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H4O14_RS01630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H4O14_RS01635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4O14_RS01640	COG0463	Glycosyl transferase, family 2
H4O14_RS01665	COG1334	flagellar protein FlaG
H4O14_RS01670	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H4O14_RS01675	COG1516	flagellar protein fliS
H4O14_RS01690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H4O14_RS01695	COG0653	protein targeting
H4O14_RS01705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_RS01715	COG2884	Cell division ATP-binding protein ftsE
H4O14_RS01720	COG2177	Part of the ABC transporter FtsEX involved in
H4O14_RS01725	COG3883	PFAM NLP P60 protein
H4O14_RS01725	COG0791	NLP P60 protein
H4O14_RS01730	COG0793	Belongs to the peptidase S41A family
H4O14_RS01730	COG3409	Peptidoglycan-binding domain 1 protein
H4O14_RS01740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_RS01745	COG0789	Transcriptional regulator
H4O14_RS01760	COG0109	protoheme IX farnesyltransferase activity
H4O14_RS01775	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_RS01780	COG4605	iron ion homeostasis
H4O14_RS01785	COG4604	ABC transporter, ATP-binding protein
H4O14_RS01790	COG4607	ABC-type enterochelin transport system periplasmic component
H4O14_RS01795	COG1136	(ABC) transporter
H4O14_RS01800	COG0577	efflux transmembrane transporter activity
H4O14_RS01805	COG0745	RESPONSE REGULATOR receiver
H4O14_RS01810	COG5002	protein histidine kinase activity
H4O14_RS01810	COG3850	Histidine kinase
H4O14_RS01815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H4O14_RS01820	COG4897	Protein conserved in bacteria
H4O14_RS01825	COG0556	nucleotide-excision repair
H4O14_RS01830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4O14_RS01840	COG3595	metallopeptidase activity
H4O14_RS01850	COG1950	PFAM Membrane protein of
H4O14_RS01855	COG1970	mechanosensitive ion channel activity
H4O14_RS01860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4O14_RS01875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H4O14_RS01880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H4O14_RS01885	COG0546	phosphoglycolate phosphatase activity
H4O14_RS01890	COG0110	maltose O-acetyltransferase activity
H4O14_RS01895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H4O14_RS01900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4O14_RS01905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4O14_RS01910	COG0131	Imidazoleglycerol-phosphate dehydratase
H4O14_RS01915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4O14_RS01920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4O14_RS01925	COG0107	imidazoleglycerol-phosphate synthase activity
H4O14_RS01930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4O14_RS01930	COG0140	phosphoribosyl-ATP diphosphatase activity
H4O14_RS01935	COG0457	Tetratricopeptide repeat
H4O14_RS01940	COG0492	ferredoxin-NADP+ reductase activity
H4O14_RS01945	COG1051	belongs to the nudix hydrolase family
H4O14_RS01950	COG1660	Displays ATPase and GTPase activities
H4O14_RS01955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H4O14_RS01960	COG1481	regulation of sporulation
H4O14_RS01965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4O14_RS01970	COG0740	serine-type endopeptidase activity
H4O14_RS02090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4O14_RS02105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4O14_RS02125	COG0148	phosphopyruvate hydratase activity
H4O14_RS02145	COG0697	spore germination
H4O14_RS02150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4O14_RS02155	COG1647	Serine aminopeptidase, S33
H4O14_RS02160	COG0557	exoribonuclease II activity
H4O14_RS02165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4O14_RS02175	COG4974	Belongs to the 'phage' integrase family
H4O14_RS02270	COG0629	single-stranded DNA binding
H4O14_RS02290	COG0582	viral genome integration into host DNA
H4O14_RS02420	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4O14_RS02465	COG1388	LysM domain
H4O14_RS02475	COG2608	mercury ion transmembrane transporter activity
H4O14_RS02480	COG2217	Heavy metal translocating P-type atpase
H4O14_RS02490	COG0805	protein transport
H4O14_RS02495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4O14_RS02510	COG1349	DNA-binding transcription factor activity
H4O14_RS02515	COG0833	amino acid
H4O14_RS02535	COG1309	transcriptional regulator
H4O14_RS02540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4O14_RS02550	COG1131	(ABC) transporter
H4O14_RS02555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H4O14_RS02570	COG0753	catalase activity
H4O14_RS02585	COG0640	Transcriptional regulator
H4O14_RS02590	COG0004	ammonium transporteR
H4O14_RS02600	COG2176	DNA-directed DNA polymerase activity
H4O14_RS02605	COG1597	lipid kinase activity
H4O14_RS02630	COG2856	Zn peptidase
H4O14_RS02640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_RS02660	COG0583	DNA-binding transcription factor activity
H4O14_RS02665	COG1376	ErfK ybiS ycfS ynhG family protein
H4O14_RS02675	COG2814	Major facilitator Superfamily
H4O14_RS02680	COG1846	Transcriptional regulator
H4O14_RS02695	COG1737	Transcriptional regulator
H4O14_RS02700	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H4O14_RS02705	COG1070	Carbohydrate kinase
H4O14_RS02710	COG0205	6-phosphofructokinase activity
H4O14_RS02720	COG0741	lytic transglycosylase activity
H4O14_RS02730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O14_RS02735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_RS02740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_RS02745	COG1733	regulation of RNA biosynthetic process
H4O14_RS02755	COG1131	(ABC) transporter
H4O14_RS02760	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H4O14_RS02765	COG0598	Magnesium transport protein CorA
H4O14_RS02775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_RS02785	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4O14_RS02790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H4O14_RS02800	COG5002	protein histidine kinase activity
H4O14_RS02830	COG0114	fumarate hydratase activity
H4O14_RS02835	COG2770	Histidine kinase
H4O14_RS02835	COG2205	protein histidine kinase activity
H4O14_RS02840	COG0745	RESPONSE REGULATOR receiver
H4O14_RS02845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_RS02850	COG2814	Major facilitator Superfamily
H4O14_RS02855	COG1309	transcriptional regulator
H4O14_RS02860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4O14_RS02870	COG2986	histidine ammonia-lyase
H4O14_RS02875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H4O14_RS02880	COG1228	amidohydrolase
H4O14_RS02885	COG0010	Belongs to the arginase family
H4O14_RS02890	COG2851	Citrate transporter
H4O14_RS02900	COG0456	acetyltransferase
H4O14_RS02900	COG1846	Transcriptional regulator
H4O14_RS02905	COG4565	transcriptional regulatory protein
H4O14_RS02910	COG3290	protein histidine kinase activity
H4O14_RS02935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4O14_RS02940	COG2011	ABC-type metal ion transport system permease component
H4O14_RS02945	COG1464	Belongs to the NlpA lipoprotein family
H4O14_RS02955	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS02960	COG0789	Transcriptional regulator
H4O14_RS02960	COG4978	Transcriptional regulator
H4O14_RS02990	COG0454	-acetyltransferase
H4O14_RS03015	COG2076	Multidrug Resistance protein
H4O14_RS03020	COG2076	Multidrug Resistance protein
H4O14_RS03030	COG1686	Belongs to the peptidase S11 family
H4O14_RS03035	COG0531	amino acid
H4O14_RS03060	COG0531	amino acid
H4O14_RS03065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4O14_RS03080	COG1301	dicarboxylic acid transport
H4O14_RS03085	COG5002	protein histidine kinase activity
H4O14_RS03090	COG0745	RESPONSE REGULATOR receiver
H4O14_RS03095	COG0569	domain protein
H4O14_RS03100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H4O14_RS03110	COG0367	asparagine synthase
H4O14_RS03125	COG5002	protein histidine kinase activity
H4O14_RS03140	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS03145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O14_RS03150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_RS03155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_RS03160	COG1120	ATPase activity
H4O14_RS03180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H4O14_RS03185	COG5577	PFAM Coat F domain
H4O14_RS03195	COG0506	proline dehydrogenase activity
H4O14_RS03200	COG2267	carboxylic ester hydrolase activity
H4O14_RS03210	COG1024	Enoyl-CoA hydratase
H4O14_RS03210	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_RS03215	COG0183	Belongs to the thiolase family
H4O14_RS03220	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS03225	COG1393	Belongs to the ArsC family
H4O14_RS03230	COG0509	glycine decarboxylation via glycine cleavage system
H4O14_RS03240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H4O14_RS03245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_RS03255	COG2873	o-acetylhomoserine
H4O14_RS03260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4O14_RS03265	COG2011	ABC-type metal ion transport system permease component
H4O14_RS03270	COG1464	Belongs to the NlpA lipoprotein family
H4O14_RS03275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4O14_RS03285	COG0396	ATPase activity
H4O14_RS03290	COG0719	Fe-S assembly protein
H4O14_RS03295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4O14_RS03300	COG0822	iron-sulfur transferase activity
H4O14_RS03305	COG0719	Fe-S assembly protein
H4O14_RS03315	COG2814	Major facilitator Superfamily
H4O14_RS03320	COG1809	phosphosulfolactate synthase activity
H4O14_RS03325	COG0406	alpha-ribazole phosphatase activity
H4O14_RS03330	COG0697	spore germination
H4O14_RS03335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_RS03345	COG1801	Protein of unknown function DUF72
H4O14_RS03350	COG0730	response to heat
H4O14_RS03355	COG0737	Belongs to the 5'-nucleotidase family
H4O14_RS03360	COG3377	Domain of unknown function (DUF1805)
H4O14_RS03370	COG0733	neurotransmitter:sodium symporter activity
H4O14_RS03380	COG0739	heme binding
H4O14_RS03385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4O14_RS03395	COG4470	Protein conserved in bacteria
H4O14_RS03410	COG2199	diguanylate cyclase activity
H4O14_RS03410	COG2200	EAL domain
H4O14_RS03410	COG3287	FIST C domain
H4O14_RS03415	COG2445	Protein of unknown function DUF86
H4O14_RS03420	COG0647	UMP catabolic process
H4O14_RS03425	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4O14_RS03430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4O14_RS03435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4O14_RS03445	COG0460	homoserine dehydrogenase
H4O14_RS03450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4O14_RS03460	COG4946	Tricorn protease homolog
H4O14_RS03460	COG1506	peptidase
H4O14_RS03460	COG0823	Involved in the tonB-independent uptake of proteins
H4O14_RS03465	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H4O14_RS03470	COG4837	Protein of unknown function (DUF1462)
H4O14_RS03475	COG1252	NADH dehydrogenase
H4O14_RS03490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H4O14_RS03495	COG0316	Belongs to the HesB IscA family
H4O14_RS03530	COG0492	ferredoxin-NADP+ reductase activity
H4O14_RS03535	COG1252	NADH dehydrogenase
H4O14_RS03555	COG3584	3D domain protein
H4O14_RS03565	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H4O14_RS03575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4O14_RS03580	COG2056	Na+-H+ antiporter family
H4O14_RS03595	COG1268	BioY protein
H4O14_RS03600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4O14_RS03605	COG3852	Histidine kinase
H4O14_RS03610	COG0697	spore germination
H4O14_RS03615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4O14_RS03620	COG0686	Belongs to the AlaDH PNT family
H4O14_RS03625	COG2508	Transcriptional regulator
H4O14_RS03625	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H4O14_RS03635	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS03655	COG1418	mRNA catabolic process
H4O14_RS03660	COG1011	Hydrolase
H4O14_RS03665	COG0398	Pfam SNARE associated Golgi protein
H4O14_RS03670	COG0789	Transcriptional regulator
H4O14_RS03675	COG1253	flavin adenine dinucleotide binding
H4O14_RS03680	COG0628	permease
H4O14_RS03690	COG1609	Transcriptional regulator
H4O14_RS03695	COG0243	molybdopterin cofactor binding
H4O14_RS03700	COG2368	4-hydroxyphenylacetate
H4O14_RS03710	COG5506	Protein of unknown function (DUF1694)
H4O14_RS03735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H4O14_RS03740	COG4989	oxidoreductase activity
H4O14_RS03750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4O14_RS03755	COG0726	polysaccharide deacetylase
H4O14_RS03760	COG1408	metallophosphoesterase
H4O14_RS03765	COG0656	L-ascorbic acid biosynthetic process
H4O14_RS03770	COG2207	Transcriptional regulator
H4O14_RS03785	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H4O14_RS03790	COG0840	transmembrane signaling receptor activity
H4O14_RS03810	COG0142	geranyltranstransferase activity
H4O14_RS03820	COG4585	Histidine kinase
H4O14_RS03825	COG2197	response regulator
H4O14_RS03835	COG2133	pyrroloquinoline quinone binding
H4O14_RS03840	COG2050	protein possibly involved in aromatic compounds catabolism
H4O14_RS03845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_RS03855	COG1320	monovalent cation:proton antiporter activity
H4O14_RS03860	COG2212	antiporter activity
H4O14_RS03865	COG1863	multisubunit Na H antiporter MnhE subunit
H4O14_RS03870	COG0651	ATP synthesis coupled electron transport
H4O14_RS03875	COG1006	Multisubunit Na H antiporter MnhC subunit
H4O14_RS03880	COG2111	Na H antiporter
H4O14_RS03885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4O14_RS03885	COG2111	Na H antiporter
H4O14_RS03900	COG3011	Protein conserved in bacteria
H4O14_RS03905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_RS03910	COG2814	Major facilitator Superfamily
H4O14_RS03915	COG5018	Exonuclease
H4O14_RS03930	COG2032	superoxide dismutase activity
H4O14_RS03965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H4O14_RS03975	COG2267	carboxylic ester hydrolase activity
H4O14_RS03980	COG1522	sequence-specific DNA binding
H4O14_RS03985	COG0436	Aminotransferase
H4O14_RS04005	COG1098	S1 RNA binding domain
H4O14_RS04010	COG2155	Conserved Protein
H4O14_RS04015	COG1979	alcohol dehydrogenase
H4O14_RS04055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4O14_RS04070	COG1253	flavin adenine dinucleotide binding
H4O14_RS04080	COG0366	Alpha amylase catalytic
H4O14_RS04085	COG0432	Pfam Uncharacterised protein family UPF0047
H4O14_RS04095	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H4O14_RS04105	COG2070	2-Nitropropane dioxygenase
H4O14_RS04110	COG3844	kynureninase activity
H4O14_RS04130	COG1823	symporter activity
H4O14_RS04145	COG1132	(ABC) transporter
H4O14_RS04150	COG1349	DNA-binding transcription factor activity
H4O14_RS04155	COG1105	Belongs to the carbohydrate kinase PfkB family
H4O14_RS04160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4O14_RS04160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4O14_RS04160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4O14_RS04175	COG2112	serine threonine protein kinase
H4O14_RS04180	COG1309	transcriptional regulator
H4O14_RS04185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4O14_RS04190	COG1285	pathogenesis
H4O14_RS04195	COG0673	inositol 2-dehydrogenase activity
H4O14_RS04200	COG2176	DNA-directed DNA polymerase activity
H4O14_RS04215	COG2259	Doxx family
H4O14_RS04220	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_RS04245	COG2814	Major facilitator Superfamily
H4O14_RS04250	COG1414	Transcriptional regulator
H4O14_RS04270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4O14_RS04290	COG1595	DNA-templated transcription, initiation
H4O14_RS04315	COG2385	sporulation resulting in formation of a cellular spore
H4O14_RS04325	COG1486	melibiose metabolic process
H4O14_RS04330	COG1447	Phosphotransferase system cellobiose-specific component IIA
H4O14_RS04335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4O14_RS04340	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4O14_RS04355	COG2310	stress, protein
H4O14_RS04360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4O14_RS04365	COG0492	ferredoxin-NADP+ reductase activity
H4O14_RS04375	COG5002	protein histidine kinase activity
H4O14_RS04380	COG4129	membrane
H4O14_RS04385	COG0730	response to heat
H4O14_RS04395	COG1388	LysM domain
H4O14_RS04395	COG3584	3D domain protein
H4O14_RS04420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4O14_RS04435	COG1966	Carbon starvation protein
H4O14_RS04440	COG3279	Response regulator of the LytR AlgR family
H4O14_RS04445	COG3275	phosphorelay sensor kinase activity
H4O14_RS04475	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_RS04475	COG2202	Pas domain
H4O14_RS04480	COG3773	Cell wall hydrolase
H4O14_RS04485	COG2132	Multicopper oxidase
H4O14_RS04490	COG0277	FAD linked oxidase domain protein
H4O14_RS04500	COG1131	(ABC) transporter
H4O14_RS04505	COG1309	transcriptional regulator
H4O14_RS04510	COG0574	Belongs to the PEP-utilizing enzyme family
H4O14_RS04510	COG3848	Pyruvate phosphate dikinase
H4O14_RS04515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4O14_RS04540	COG2318	DinB family
H4O14_RS04545	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_RS04560	COG1247	-acetyltransferase
H4O14_RS04565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4O14_RS04575	COG3859	Proton-coupled thiamine transporter YuaJ
H4O14_RS04585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4O14_RS04590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_RS04595	COG1116	anion transmembrane transporter activity
H4O14_RS04725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H4O14_RS04730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H4O14_RS04735	COG0297	glycogen (starch) synthase activity
H4O14_RS04740	COG0058	SHG alpha-glucan phosphorylase activity
H4O14_RS04755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4O14_RS04760	COG1575	Belongs to the MenA family. Type 1 subfamily
H4O14_RS04765	COG1169	isochorismate synthase
H4O14_RS04770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H4O14_RS04775	COG0596	Alpha beta hydrolase
H4O14_RS04780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H4O14_RS04785	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_RS04790	COG4948	Mandelate Racemase Muconate Lactonizing
H4O14_RS04795	COG0803	Belongs to the bacterial solute-binding protein 9 family
H4O14_RS04800	COG1121	(ABC) transporter
H4O14_RS04805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4O14_RS04805	COG1321	iron dependent repressor
H4O14_RS04810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4O14_RS04820	COG1294	oxidase, subunit
H4O14_RS04825	COG1271	oxidase subunit
H4O14_RS04835	COG0523	cobalamin synthesis protein
H4O14_RS04845	COG0523	cobalamin synthesis protein
H4O14_RS04850	COG0288	reversible hydration of carbon dioxide
H4O14_RS04855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H4O14_RS04865	COG0788	formyltetrahydrofolate deformylase activity
H4O14_RS04885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H4O14_RS04890	COG1469	GTP cyclohydrolase I activity
H4O14_RS04895	COG0701	Predicted permease
H4O14_RS04915	COG0783	Belongs to the Dps family
H4O14_RS04930	COG0494	nUDIX hydrolase
H4O14_RS04940	COG1404	Belongs to the peptidase S8 family
H4O14_RS04945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4O14_RS04950	COG1116	anion transmembrane transporter activity
H4O14_RS04955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_RS04960	COG1506	peptidase
H4O14_RS04970	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H4O14_RS04975	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4O14_RS04980	COG0367	asparagine synthase
H4O14_RS04985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4O14_RS04985	COG0438	transferase activity, transferring glycosyl groups
H4O14_RS04990	COG0671	phosphoesterase, PA-phosphatase related
H4O14_RS04995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4O14_RS05000	COG2267	carboxylic ester hydrolase activity
H4O14_RS05010	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H4O14_RS05015	COG1242	4 iron, 4 sulfur cluster binding
H4O14_RS05030	COG1725	Transcriptional regulator
H4O14_RS05035	COG1131	(ABC) transporter
H4O14_RS05045	COG1136	(ABC) transporter
H4O14_RS05050	COG0577	efflux transmembrane transporter activity
H4O14_RS05065	COG2814	Major facilitator Superfamily
H4O14_RS05075	COG0495	leucyl-tRNA aminoacylation
H4O14_RS05080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4O14_RS05095	COG2081	HI0933 family
H4O14_RS05100	COG2244	polysaccharide biosynthetic process
H4O14_RS05105	COG1187	pseudouridine synthase activity
H4O14_RS05110	COG1349	DNA-binding transcription factor activity
H4O14_RS05115	COG2252	PERMEase
H4O14_RS05120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4O14_RS05130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4O14_RS05135	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H4O14_RS05140	COG1380	Effector of murein hydrolase LrgA
H4O14_RS05145	COG1346	cytolysis
H4O14_RS05155	COG1597	lipid kinase activity
H4O14_RS05160	COG1523	belongs to the glycosyl hydrolase 13 family
H4O14_RS05165	COG0510	thiamine kinase activity
H4O14_RS05175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4O14_RS05180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4O14_RS05185	COG5584	Small secreted protein
H4O14_RS05190	COG1363	Peptidase, m42
H4O14_RS05195	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H4O14_RS05210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_RS05215	COG4848	Belongs to the UPF0354 family
H4O14_RS05220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4O14_RS05225	COG1674	ftsk spoiiie
H4O14_RS05230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4O14_RS05235	COG2309	aminopeptidase activity
H4O14_RS05240	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H4O14_RS05245	COG4980	gas vesicle protein
H4O14_RS05250	COG3118	belongs to the thioredoxin family
H4O14_RS05255	COG0849	cell division
H4O14_RS05260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H4O14_RS05260	COG1605	Chorismate mutase
H4O14_RS05265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4O14_RS05305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4O14_RS05315	COG1086	Polysaccharide biosynthesis protein
H4O14_RS05325	COG1609	Transcriptional regulator
H4O14_RS05330	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4O14_RS05335	COG0517	IMP dehydrogenase activity
H4O14_RS05340	COG0454	-acetyltransferase
H4O14_RS05345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4O14_RS05355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4O14_RS05360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4O14_RS05365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H4O14_RS05370	COG2199	diguanylate cyclase activity
H4O14_RS05370	COG2203	Gaf domain
H4O14_RS05375	COG0626	cystathionine gamma-synthase activity
H4O14_RS05380	COG1956	GAF domain-containing protein
H4O14_RS05385	COG1309	transcriptional regulator
H4O14_RS05390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H4O14_RS05395	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H4O14_RS05400	COG1114	Component of the transport system for branched-chain amino acids
H4O14_RS05405	COG1104	cysteine desulfurase activity
H4O14_RS05410	COG0301	tRNA thio-modification
H4O14_RS05425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4O14_RS05430	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H4O14_RS05435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4O14_RS05440	COG0616	signal peptide processing
H4O14_RS05445	COG1714	RDD family
H4O14_RS05455	COG3874	Sporulation protein YtfJ
H4O14_RS05460	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H4O14_RS05465	COG0827	DNA restriction-modification system
H4O14_RS05470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H4O14_RS05475	COG1757	Na H antiporter
H4O14_RS05485	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4O14_RS05500	COG0165	Argininosuccinate lyase
H4O14_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS05525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H4O14_RS05550	COG4109	DRTGG domain
H4O14_RS05560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H4O14_RS05580	COG0587	DNA-directed DNA polymerase activity
H4O14_RS05585	COG0281	malic enzyme
H4O14_RS05590	COG1725	Transcriptional regulator
H4O14_RS05595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4O14_RS05600	COG0825	malonyl-CoA metabolic process
H4O14_RS05605	COG0205	6-phosphofructokinase activity
H4O14_RS05615	COG3030	protein affecting phage T7 exclusion by the F plasmid
H4O14_RS05620	COG0628	permease
H4O14_RS05630	COG0372	Belongs to the citrate synthase family
H4O14_RS05635	COG0538	isocitrate dehydrogenase activity
H4O14_RS05640	COG0039	L-malate dehydrogenase activity
H4O14_RS05650	COG0745	RESPONSE REGULATOR receiver
H4O14_RS05655	COG5002	protein histidine kinase activity
H4O14_RS05660	COG0330	HflC and HflK could
H4O14_RS05665	COG0330	HflC and HflK could
H4O14_RS05670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4O14_RS05670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4O14_RS05675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4O14_RS05680	COG1971	Probably functions as a manganese efflux pump
H4O14_RS05685	COG0237	dephospho-CoA kinase activity
H4O14_RS05690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4O14_RS05695	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H4O14_RS05705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4O14_RS05710	COG3611	Membrane attachment protein
H4O14_RS05715	COG1484	DNA-dependent DNA replication
H4O14_RS05725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4O14_RS05730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4O14_RS05740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4O14_RS05765	COG1363	Peptidase, m42
H4O14_RS05775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4O14_RS05780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4O14_RS05785	COG0072	phenylalanine-tRNA ligase activity
H4O14_RS05785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4O14_RS05790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4O14_RS05800	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4O14_RS05805	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4O14_RS05810	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H4O14_RS05815	COG1286	toxin biosynthetic process
H4O14_RS05820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H4O14_RS05820	COG1796	DNA polymerase
H4O14_RS05830	COG3766	membrane
H4O14_RS05835	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_RS05840	COG1309	transcriptional regulator
H4O14_RS05845	COG1024	Enoyl-CoA hydratase
H4O14_RS05850	COG2086	electron transfer activity
H4O14_RS05855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H4O14_RS05860	COG3118	belongs to the thioredoxin family
H4O14_RS05865	COG0322	excinuclease ABC activity
H4O14_RS05870	COG0527	aspartate kinase activity
H4O14_RS05875	COG1719	4-vinyl reductase, 4VR
H4O14_RS05880	COG2009	succinate dehydrogenase
H4O14_RS05885	COG1053	succinate dehydrogenase
H4O14_RS05890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4O14_RS05895	COG0824	Thioesterase
H4O14_RS05900	COG2197	response regulator
H4O14_RS05905	COG1846	Transcriptional regulator
H4O14_RS05915	COG5401	PFAM Sporulation and spore germination
H4O14_RS05920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4O14_RS05925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H4O14_RS05930	COG0622	Phosphoesterase
H4O14_RS05940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4O14_RS05945	COG0028	Belongs to the TPP enzyme family
H4O14_RS05950	COG0440	acetolactate synthase activity
H4O14_RS05955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4O14_RS05960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4O14_RS05965	COG0473	3-isopropylmalate dehydrogenase activity
H4O14_RS05970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4O14_RS05975	COG0066	3-isopropylmalate dehydratase activity
H4O14_RS05980	COG1477	protein flavinylation
H4O14_RS05980	COG0457	Tetratricopeptide repeat
H4O14_RS05985	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4O14_RS05990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H4O14_RS05995	COG1067	ATP-dependent peptidase activity
H4O14_RS05995	COG0470	DNA polymerase III
H4O14_RS06000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4O14_RS06005	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H4O14_RS06020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4O14_RS06025	COG0181	hydroxymethylbilane synthase activity
H4O14_RS06035	COG0113	porphobilinogen synthase activity
H4O14_RS06040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H4O14_RS06055	COG1388	LysM domain
H4O14_RS06055	COG1388	LysM domain
H4O14_RS06060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4O14_RS06070	COG0525	valine-tRNA ligase activity
H4O14_RS06075	COG0285	dihydrofolate synthase activity
H4O14_RS06110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4O14_RS06120	COG1459	type II secretion system
H4O14_RS06125	COG2165	general secretion pathway protein
H4O14_RS06130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H4O14_RS06160	COG2003	Belongs to the UPF0758 family
H4O14_RS06165	COG1077	Cell shape determining protein MreB Mrl
H4O14_RS06175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H4O14_RS06180	COG0850	regulation of cytokinetic process
H4O14_RS06185	COG2894	cell division
H4O14_RS06190	COG0739	heme binding
H4O14_RS06195	COG1994	Peptidase M50
H4O14_RS06200	COG1530	ribonuclease E activity
H4O14_RS06205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H4O14_RS06210	COG2868	ribosomal protein
H4O14_RS06220	COG3290	protein histidine kinase activity
H4O14_RS06230	COG4492	Belongs to the UPF0735 family
H4O14_RS06235	COG0077	Prephenate dehydratase
H4O14_RS06240	COG1827	regulation of RNA biosynthetic process
H4O14_RS06245	COG1104	cysteine desulfurase activity
H4O14_RS06250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H4O14_RS06255	COG0157	Belongs to the NadC ModD family
H4O14_RS06260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H4O14_RS06280	COG0632	four-way junction helicase activity
H4O14_RS06285	COG2255	four-way junction helicase activity
H4O14_RS06295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H4O14_RS06305	COG1862	Preprotein translocase
H4O14_RS06315	COG2323	membrane
H4O14_RS06320	COG2244	polysaccharide biosynthetic process
H4O14_RS06330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4O14_RS06330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4O14_RS06335	COG5416	Lipopolysaccharide assembly protein A domain
H4O14_RS06340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H4O14_RS06340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H4O14_RS06345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H4O14_RS06350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4O14_RS06355	COG1490	D-aminoacyl-tRNA deacylase activity
H4O14_RS06360	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4O14_RS06360	COG4991	sh3 domain protein
H4O14_RS06360	COG3103	Sh3 type 3 domain protein
H4O14_RS06375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4O14_RS06385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4O14_RS06390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4O14_RS06395	COG2364	Membrane
H4O14_RS06400	COG1959	2 iron, 2 sulfur cluster binding
H4O14_RS06405	COG1104	cysteine desulfurase activity
H4O14_RS06420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4O14_RS06440	COG0628	permease
H4O14_RS06445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4O14_RS06450	COG4472	Bacterial protein of unknown function (DUF965)
H4O14_RS06455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4O14_RS06460	COG3906	Belongs to the UPF0473 family
H4O14_RS06465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4O14_RS06470	COG4122	O-methyltransferase activity
H4O14_RS06475	COG0826	peptidase U32
H4O14_RS06480	COG0826	peptidase U32
H4O14_RS06485	COG0572	uridine kinase
H4O14_RS06490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4O14_RS06495	COG0768	penicillin binding
H4O14_RS06510	COG2226	methyltransferase
H4O14_RS06515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4O14_RS06520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4O14_RS06525	COG0626	cystathionine gamma-synthase activity
H4O14_RS06535	COG2755	lipolytic protein G-D-S-L family
H4O14_RS06555	COG1183	phosphatidylcholine synthase activity
H4O14_RS06560	COG0688	phosphatidylethanolamine metabolic process
H4O14_RS06570	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H4O14_RS06575	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H4O14_RS06585	COG1534	Rna-binding protein
H4O14_RS06590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4O14_RS06595	COG1713	HD superfamily hydrolase involved in NAD metabolism
H4O14_RS06600	COG0799	negative regulation of ribosome biogenesis
H4O14_RS06605	COG2226	methyltransferase
H4O14_RS06610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4O14_RS06615	COG1555	photosystem II stabilization
H4O14_RS06615	COG1596	polysaccharide export
H4O14_RS06620	COG2131	deaminase
H4O14_RS06625	COG0658	competence protein
H4O14_RS06625	COG2333	competence protein COMEC
H4O14_RS06635	COG1466	dna polymerase III delta subunit
H4O14_RS06640	COG0268	Binds directly to 16S ribosomal RNA
H4O14_RS06650	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4O14_RS06660	COG0481	GTPase activity
H4O14_RS06665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4O14_RS06675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4O14_RS06680	COG0443	Heat shock 70 kDa protein
H4O14_RS06685	COG0484	heat shock protein binding
H4O14_RS06690	COG2264	protein methyltransferase activity
H4O14_RS06695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4O14_RS06700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4O14_RS06705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H4O14_RS06710	COG1283	sodium-dependent phosphate transmembrane transporter activity
H4O14_RS06715	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H4O14_RS06720	COG1610	YqeY-like protein
H4O14_RS06725	COG1030	water channel activity
H4O14_RS06730	COG4864	UPF0365 protein
H4O14_RS06750	COG1702	phosphate starvation-inducible protein PhoH
H4O14_RS06755	COG1480	7TM receptor with intracellular HD hydrolase
H4O14_RS06760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H4O14_RS06765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H4O14_RS06770	COG0295	cytidine deaminase activity
H4O14_RS06775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4O14_RS06785	COG1381	Involved in DNA repair and RecF pathway recombination
H4O14_RS06790	COG0752	glycyl-tRNA synthetase alpha subunit
H4O14_RS06795	COG0751	glycine-tRNA ligase activity
H4O14_RS06800	COG0517	IMP dehydrogenase activity
H4O14_RS06805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H4O14_RS06810	COG1671	Belongs to the UPF0178 family
H4O14_RS06815	COG0358	DNA primase activity
H4O14_RS06820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4O14_RS06825	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS06830	COG2010	Cytochrome c
H4O14_RS06835	COG2384	SAM-dependent methyltransferase
H4O14_RS06840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H4O14_RS06845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4O14_RS06855	COG0513	Belongs to the DEAD box helicase family
H4O14_RS06860	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H4O14_RS06870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_RS06875	COG1121	(ABC) transporter
H4O14_RS06880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4O14_RS06885	COG0735	belongs to the Fur family
H4O14_RS06890	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H4O14_RS06895	COG4709	membrane
H4O14_RS06910	COG0840	transmembrane signaling receptor activity
H4O14_RS06915	COG5521	maltodextrose utilization protein MalA
H4O14_RS06920	COG1283	sodium-dependent phosphate transmembrane transporter activity
H4O14_RS06925	COG2839	Protein conserved in bacteria
H4O14_RS06935	COG0477	Major facilitator Superfamily
H4O14_RS06940	COG0768	penicillin binding
H4O14_RS06950	COG0573	inorganic phosphate transmembrane transporter activity
H4O14_RS06955	COG0581	inorganic phosphate transmembrane transporter activity
H4O14_RS06960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4O14_RS06965	COG0704	Plays a role in the regulation of phosphate uptake
H4O14_RS06970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4O14_RS06990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4O14_RS07005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4O14_RS07020	COG0457	Tetratricopeptide repeat
H4O14_RS07020	COG0705	Rhomboid family
H4O14_RS07025	COG4483	Protein conserved in bacteria
H4O14_RS07030	COG1940	carbohydrate kinase activity
H4O14_RS07035	COG1368	sulfuric ester hydrolase activity
H4O14_RS07050	COG0011	TIGRFAM Protein of
H4O14_RS07065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4O14_RS07080	COG1393	Belongs to the ArsC family
H4O14_RS07090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4O14_RS07095	COG1459	type II secretion system
H4O14_RS07100	COG4537	Required for transformation and DNA binding
H4O14_RS07105	COG4970	Tfp pilus assembly protein FimT
H4O14_RS07110	COG4940	Competence protein ComGF
H4O14_RS07120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4O14_RS07165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H4O14_RS07170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4O14_RS07175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4O14_RS07180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4O14_RS07185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4O14_RS07190	COG0095	Lipoate-protein ligase
H4O14_RS07200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4O14_RS07205	COG1321	iron dependent repressor
H4O14_RS07210	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4O14_RS07220	COG3872	metal-dependent enzyme
H4O14_RS07230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4O14_RS07235	COG0006	proline dipeptidase activity
H4O14_RS07255	COG3854	ATPases associated with a variety of cellular activities
H4O14_RS07295	COG0511	ligase activity, forming carbon-carbon bonds
H4O14_RS07300	COG0439	Biotin carboxylase
H4O14_RS07305	COG1302	Protein conserved in bacteria
H4O14_RS07310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4O14_RS07315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4O14_RS07320	COG1570	exodeoxyribonuclease VII activity
H4O14_RS07325	COG1722	exodeoxyribonuclease VII activity
H4O14_RS07330	COG0142	geranyltranstransferase activity
H4O14_RS07335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4O14_RS07340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H4O14_RS07345	COG1438	arginine binding
H4O14_RS07350	COG0497	DNA recombination
H4O14_RS07355	COG0750	zinc metalloprotease
H4O14_RS07360	COG0745	RESPONSE REGULATOR receiver
H4O14_RS07365	COG3093	addiction module antidote protein HigA
H4O14_RS07370	COG0584	glycerophosphoryl diester phosphodiesterase
H4O14_RS07380	COG3290	protein histidine kinase activity
H4O14_RS07380	COG3829	transcription factor binding
H4O14_RS07385	COG0280	phosphate acetyltransferase
H4O14_RS07395	COG3426	butyrate kinase activity
H4O14_RS07400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4O14_RS07405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4O14_RS07410	COG0022	dehydrogenase e1 component
H4O14_RS07415	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4O14_RS07420	COG1597	lipid kinase activity
H4O14_RS07425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_RS07430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_RS07430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_RS07450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O14_RS07455	COG0765	amino acid transport
H4O14_RS07460	COG1126	abc transporter atp-binding protein
H4O14_RS07465	COG4129	membrane
H4O14_RS07470	COG1376	ErfK ybiS ycfS ynhG family protein
H4O14_RS07480	COG0346	lactoylglutathione lyase activity
H4O14_RS07485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4O14_RS07490	COG2195	Cleaves the N-terminal amino acid of tripeptides
H4O14_RS07495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4O14_RS07505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4O14_RS07510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H4O14_RS07520	COG3655	Transcriptional regulator
H4O14_RS07525	COG3739	integral membrane protein
H4O14_RS07535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4O14_RS07540	COG1234	tRNA 3'-trailer cleavage
H4O14_RS07560	COG1902	pentaerythritol trinitrate reductase activity
H4O14_RS07565	COG4187	Peptidase family M20/M25/M40
H4O14_RS07580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4O14_RS07585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4O14_RS07590	COG0300	oxidoreductase activity
H4O14_RS07600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4O14_RS07625	COG1073	alpha beta
H4O14_RS07635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4O14_RS07640	COG0183	Belongs to the thiolase family
H4O14_RS07645	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4O14_RS07650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4O14_RS07675	COG0667	Aldo Keto reductase
H4O14_RS07685	COG0494	nUDIX hydrolase
H4O14_RS07690	COG1379	DNA repair
H4O14_RS07705	COG1300	Membrane
H4O14_RS07710	COG0735	belongs to the Fur family
H4O14_RS07720	COG4974	Belongs to the 'phage' integrase family
H4O14_RS07725	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H4O14_RS07740	COG1686	Belongs to the peptidase S11 family
H4O14_RS07745	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_RS07775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4O14_RS07790	COG0697	spore germination
H4O14_RS07795	COG0019	diaminopimelate decarboxylase activity
H4O14_RS07800	COG4086	secreted protein
H4O14_RS07805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4O14_RS07815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4O14_RS07815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4O14_RS07820	COG0307	riboflavin synthase, alpha
H4O14_RS07825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4O14_RS07825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4O14_RS07830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4O14_RS07840	COG1547	Domain of unknown function (DUF309)
H4O14_RS07855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4O14_RS07870	COG1686	Belongs to the peptidase S11 family
H4O14_RS07875	COG2715	membrane protein required for spore maturation
H4O14_RS07880	COG0700	Nucleoside recognition
H4O14_RS07885	COG1187	pseudouridine synthase activity
H4O14_RS07890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_RS07895	COG1333	cytochrome c biogenesis protein
H4O14_RS07900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4O14_RS07905	COG0745	RESPONSE REGULATOR receiver
H4O14_RS07910	COG5002	protein histidine kinase activity
H4O14_RS07925	COG2096	Adenosyltransferase
H4O14_RS07930	COG1595	DNA-templated transcription, initiation
H4O14_RS07940	COG1388	LysM domain
H4O14_RS07940	COG3942	CHAP domain
H4O14_RS07945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H4O14_RS07950	COG5002	protein histidine kinase activity
H4O14_RS07955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4O14_RS07960	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H4O14_RS07965	COG1141	Ferredoxin
H4O14_RS07970	COG4955	Helix-turn-helix domain
H4O14_RS07975	COG0514	ATP-dependent DNA helicase (RecQ)
H4O14_RS07980	COG1266	CAAX protease self-immunity
H4O14_RS08005	COG0789	Transcriptional regulator
H4O14_RS08010	COG4862	establishment of competence for transformation
H4O14_RS08015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4O14_RS08020	COG0492	ferredoxin-NADP+ reductase activity
H4O14_RS08025	COG0252	asparaginase activity
H4O14_RS08030	COG2339	peptidase activity
H4O14_RS08035	COG3409	Peptidoglycan-binding domain 1 protein
H4O14_RS08035	COG3773	Cell wall hydrolase
H4O14_RS08040	COG2959	enzyme of heme biosynthesis
H4O14_RS08055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4O14_RS08065	COG0539	negative regulation of cytoplasmic translation
H4O14_RS08070	COG1304	FMN binding
H4O14_RS08095	COG1160	GTP binding
H4O14_RS08115	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H4O14_RS08120	COG0776	regulation of translation
H4O14_RS08135	COG0142	geranyltranstransferase activity
H4O14_RS08140	COG2226	methyltransferase
H4O14_RS08145	COG0142	geranyltranstransferase activity
H4O14_RS08150	COG0105	UTP biosynthetic process
H4O14_RS08155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4O14_RS08160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4O14_RS08165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H4O14_RS08170	COG4401	Chorismate mutase type I
H4O14_RS08180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4O14_RS08185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4O14_RS08190	COG0134	indole-3-glycerol-phosphate synthase activity
H4O14_RS08195	COG0135	phosphoribosylanthranilate isomerase activity
H4O14_RS08200	COG0133	tryptophan synthase activity
H4O14_RS08205	COG0159	tryptophan synthase activity
H4O14_RS08210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4O14_RS08215	COG0287	Prephenate dehydrogenase
H4O14_RS08230	COG0457	Tetratricopeptide repeat
H4O14_RS08235	COG5582	Belongs to the UPF0302 family
H4O14_RS08240	COG1523	belongs to the glycosyl hydrolase 13 family
H4O14_RS08250	COG0723	plastoquinol--plastocyanin reductase activity
H4O14_RS08255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4O14_RS08260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4O14_RS08260	COG2010	Cytochrome c
H4O14_RS08265	COG4347	Protein of unknown function (DUF1405)
H4O14_RS08275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_RS08280	COG1694	Mazg nucleotide pyrophosphohydrolase
H4O14_RS08285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H4O14_RS08290	COG1803	Methylglyoxal synthase
H4O14_RS08295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4O14_RS08300	COG0438	transferase activity, transferring glycosyl groups
H4O14_RS08305	COG0617	tRNA 3'-terminal CCA addition
H4O14_RS08315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H4O14_RS08320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H4O14_RS08325	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H4O14_RS08330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4O14_RS08330	COG1199	ATP-dependent helicase activity
H4O14_RS08345	COG0436	Aminotransferase
H4O14_RS08350	COG0017	Asparaginyl-tRNA synthetase
H4O14_RS08355	COG3935	DnaD domain protein
H4O14_RS08360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4O14_RS08375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_RS08375	COG4499	WXG100 protein secretion system (Wss), protein YukC
H4O14_RS08380	COG3331	DNA recombination
H4O14_RS08440	COG2190	(PTS) system
H4O14_RS08445	COG1205	dead DEAH box helicase
H4O14_RS08445	COG1111	helicase
H4O14_RS08450	COG3359	exonuclease
H4O14_RS08460	COG4474	Belongs to the UPF0398 family
H4O14_RS08475	COG0116	Belongs to the methyltransferase superfamily
H4O14_RS08485	COG1199	ATP-dependent helicase activity
H4O14_RS08490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H4O14_RS08505	COG2233	PERMEase
H4O14_RS08515	COG1376	ErfK ybiS ycfS ynhG family protein
H4O14_RS08525	COG1247	-acetyltransferase
H4O14_RS08530	COG3424	synthase
H4O14_RS08535	COG1755	Isoprenylcysteine carboxyl methyltransferase
H4O14_RS08550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4O14_RS08560	COG0490	domain, Protein
H4O14_RS08565	COG0475	glutathione-regulated potassium exporter activity
H4O14_RS08575	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H4O14_RS08595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4O14_RS08600	COG0702	epimerase
H4O14_RS08615	COG0328	RNA-DNA hybrid ribonuclease activity
H4O14_RS08640	COG1278	Cold shock
H4O14_RS08670	COG2226	methyltransferase
H4O14_RS08685	COG1988	membrane-bound metal-dependent
H4O14_RS08690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4O14_RS08695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H4O14_RS08715	COG0386	Belongs to the glutathione peroxidase family
H4O14_RS08725	COG1307	EDD domain protein, DegV family
H4O14_RS08730	COG1418	mRNA catabolic process
H4O14_RS08735	COG1413	lyase activity
H4O14_RS08745	COG0024	Methionine aminopeptidase
H4O14_RS08750	COG0129	dihydroxy-acid dehydratase activity
H4O14_RS08760	COG2136	Putative SAM-dependent methyltransferase
H4O14_RS08760	COG2521	methyltransferase
H4O14_RS08775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4O14_RS08780	COG0861	Integral membrane protein TerC family
H4O14_RS08800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4O14_RS08805	COG1272	protein, Hemolysin III
H4O14_RS08810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H4O14_RS08815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4O14_RS08825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4O14_RS08855	COG1999	signal sequence binding
H4O14_RS08860	COG2140	Oxalate decarboxylase
H4O14_RS08870	COG4698	Protein conserved in bacteria
H4O14_RS08880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_RS08910	COG1846	Transcriptional regulator
H4O14_RS08915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4O14_RS08915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4O14_RS08925	COG0346	lactoylglutathione lyase activity
H4O14_RS08930	COG0456	acetyltransferase
H4O14_RS08940	COG1278	Cold shock
H4O14_RS08970	COG2267	carboxylic ester hydrolase activity
H4O14_RS08985	COG1078	dGTPase activity
H4O14_RS08990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O14_RS09000	COG0778	Nitroreductase
H4O14_RS09005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4O14_RS09035	COG0456	acetyltransferase
H4O14_RS09045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4O14_RS09050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4O14_RS09060	COG0697	spore germination
H4O14_RS09070	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4O14_RS09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_RS09110	COG1609	Transcriptional regulator
H4O14_RS09120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H4O14_RS09135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H4O14_RS09145	COG2186	Transcriptional regulator
H4O14_RS09150	COG0277	FAD linked oxidase domain protein
H4O14_RS09155	COG0385	Bile acid
H4O14_RS09160	COG0372	Belongs to the citrate synthase family
H4O14_RS09165	COG0583	DNA-binding transcription factor activity
H4O14_RS09175	COG1113	amino acid transport
H4O14_RS09185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4O14_RS09215	COG2364	Membrane
H4O14_RS09220	COG1846	Transcriptional regulator
H4O14_RS09225	COG0456	acetyltransferase
H4O14_RS09245	COG0346	lactoylglutathione lyase activity
H4O14_RS09250	COG0640	Transcriptional regulator
H4O14_RS09280	COG1834	amidinotransferase
H4O14_RS09290	COG3403	YqcI/YcgG family
H4O14_RS09295	COG1280	lysine exporter protein (LysE YggA)
H4O14_RS09300	COG1113	amino acid transport
H4O14_RS09310	COG2814	Major facilitator Superfamily
H4O14_RS09340	COG1404	Belongs to the peptidase S8 family
H4O14_RS09390	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H4O14_RS09405	COG2814	Major facilitator Superfamily
H4O14_RS09410	COG1309	transcriptional regulator
H4O14_RS09415	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_RS09420	COG1609	Transcriptional regulator
H4O14_RS09430	COG0673	inositol 2-dehydrogenase activity
H4O14_RS09435	COG0673	inositol 2-dehydrogenase activity
H4O14_RS09440	COG1082	Xylose isomerase domain protein TIM barrel
H4O14_RS09445	COG2814	Major facilitator Superfamily
H4O14_RS09460	COG0861	Integral membrane protein TerC family
H4O14_RS09480	COG3383	formate dehydrogenase (NAD+) activity
H4O14_RS09485	COG2427	Protein of unknown function (DUF1641)
H4O14_RS09495	COG0489	protein tyrosine kinase activity
H4O14_RS09500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4O14_RS09515	COG0746	molybdenum cofactor guanylyltransferase activity
H4O14_RS09520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4O14_RS09525	COG0303	'Molybdopterin
H4O14_RS09530	COG1763	Mo-molybdopterin cofactor biosynthetic process
H4O14_RS09535	COG0314	molybdopterin synthase activity
H4O14_RS09540	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H4O14_RS09545	COG3383	formate dehydrogenase (NAD+) activity
H4O14_RS09555	COG2427	Protein of unknown function (DUF1641)
H4O14_RS09565	COG5609	conserved protein (DUF2294)
H4O14_RS09575	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4O14_RS09595	COG1263	PTS System
H4O14_RS09595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_RS09600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4O14_RS09605	COG0346	lactoylglutathione lyase activity
H4O14_RS09615	COG1309	transcriptional regulator
H4O14_RS09620	COG4221	oxidoreductase activity
H4O14_RS09625	COG2723	6-phospho-beta-galactosidase activity
H4O14_RS09630	COG2188	Transcriptional regulator
H4O14_RS09640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H4O14_RS09645	COG1959	2 iron, 2 sulfur cluster binding
H4O14_RS09650	COG0702	epimerase
H4O14_RS09655	COG1132	(ABC) transporter
H4O14_RS09660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4O14_RS09665	COG0697	spore germination
H4O14_RS09680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4O14_RS09685	COG0492	ferredoxin-NADP+ reductase activity
H4O14_RS09720	COG5566	PFAM Mor transcription activator
H4O14_RS09745	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H4O14_RS09760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H4O14_RS09765	COG1595	DNA-templated transcription, initiation
H4O14_RS09785	COG1785	Belongs to the alkaline phosphatase family
H4O14_RS09795	COG1114	Component of the transport system for branched-chain amino acids
H4O14_RS09800	COG1125	glycine betaine transport
H4O14_RS09800	COG0517	IMP dehydrogenase activity
H4O14_RS09805	COG1174	glycine betaine transport
H4O14_RS09810	COG1732	Glycine betaine
H4O14_RS09815	COG1174	glycine betaine transport
H4O14_RS09825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4O14_RS09835	COG0598	Magnesium transport protein CorA
H4O14_RS09865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4O14_RS09870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4O14_RS09875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H4O14_RS09900	COG2814	Major facilitator Superfamily
H4O14_RS09910	COG2207	Transcriptional regulator
H4O14_RS09910	COG3708	Transcriptional regulator
H4O14_RS09915	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_RS09925	COG1454	alcohol dehydrogenase
H4O14_RS09935	COG2318	DinB family
H4O14_RS09965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4O14_RS09985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_RS10030	COG0697	spore germination
H4O14_RS10045	COG5634	Uncharacterized conserved protein (DUF2278)
H4O14_RS10050	COG1609	Transcriptional regulator
H4O14_RS10055	COG1653	transport
H4O14_RS10060	COG4209	transmembrane transport
H4O14_RS10065	COG0395	ABC-type sugar transport system, permease component
H4O14_RS10080	COG3842	ATPase activity
H4O14_RS10085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O14_RS10090	COG0765	amino acid transport
H4O14_RS10125	COG0596	Alpha beta hydrolase
H4O14_RS10130	COG0431	NADPH-dependent FMN reductase
H4O14_RS10135	COG5583	Uncharacterized small protein (DUF2292)
H4O14_RS10140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_RS10150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4O14_RS10155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_RS10160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_RS10165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_RS10185	COG0076	glutamate decarboxylase activity
H4O14_RS10190	COG3878	Protein conserved in bacteria
H4O14_RS10195	COG2610	gluconate transmembrane transporter activity
H4O14_RS10200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4O14_RS10205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4O14_RS10210	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS10215	COG3829	transcription factor binding
H4O14_RS10215	COG3290	protein histidine kinase activity
H4O14_RS10225	COG2207	Transcriptional regulator
H4O14_RS10240	COG0640	Transcriptional regulator
H4O14_RS10260	COG1393	Belongs to the ArsC family
H4O14_RS10265	COG2357	RelA SpoT domain protein
H4O14_RS10280	COG4085	toxin activity
H4O14_RS10280	COG1525	nuclease
H4O14_RS10280	COG0737	Belongs to the 5'-nucleotidase family
H4O14_RS10315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4O14_RS10320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4O14_RS10325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4O14_RS10330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4O14_RS10335	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_RS10340	COG0456	acetyltransferase
H4O14_RS10345	COG3829	transcription factor binding
H4O14_RS10350	COG1509	lysine 2,3-aminomutase activity
H4O14_RS10370	COG3647	Membrane
H4O14_RS10380	COG0671	phosphoesterase, PA-phosphatase related
H4O14_RS10405	COG1846	Transcriptional regulator
H4O14_RS10410	COG0477	Major facilitator Superfamily
H4O14_RS10415	COG2318	DinB family
H4O14_RS10425	COG2814	Major facilitator Superfamily
H4O14_RS10435	COG1349	DNA-binding transcription factor activity
H4O14_RS10440	COG0673	inositol 2-dehydrogenase activity
H4O14_RS10460	COG1279	arginine transmembrane transporter activity
H4O14_RS10465	COG2031	fatty acid transporter
H4O14_RS10470	COG0583	DNA-binding transcription factor activity
H4O14_RS10475	COG3180	Ammonia monooxygenase
H4O14_RS10510	COG3858	chitin binding
H4O14_RS10565	COG0346	lactoylglutathione lyase activity
H4O14_RS10575	COG2814	Major facilitator Superfamily
H4O14_RS10580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_RS10605	COG1131	(ABC) transporter
H4O14_RS10620	COG5522	Integral membrane protein (intg_mem_TP0381)
H4O14_RS10655	COG0515	serine threonine protein kinase
H4O14_RS10655	COG2815	serine threonine protein kinase
H4O14_RS10660	COG4326	sporulation control protein
H4O14_RS10685	COG0697	spore germination
H4O14_RS10695	COG0584	glycerophosphoryl diester phosphodiesterase
H4O14_RS10705	COG0671	phosphoesterase, PA-phosphatase related
H4O14_RS10725	COG1876	peptidase activity
H4O14_RS10740	COG2226	methyltransferase
H4O14_RS10745	COG0793	Belongs to the peptidase S41A family
H4O14_RS10745	COG3409	Peptidoglycan-binding domain 1 protein
H4O14_RS10750	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4O14_RS10755	COG0400	carboxylic ester hydrolase activity
H4O14_RS10760	COG0778	Nitroreductase
H4O14_RS10765	COG1733	regulation of RNA biosynthetic process
H4O14_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS10785	COG4876	unkown
H4O14_RS10800	COG2962	Rard protein
H4O14_RS10810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4O14_RS10815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4O14_RS10820	COG0534	Mate efflux family protein
H4O14_RS10825	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H4O14_RS10830	COG2252	PERMEase
H4O14_RS10845	COG0791	NLP P60 protein
H4O14_RS10845	COG1388	LysM domain
H4O14_RS10850	COG1309	transcriptional regulator
H4O14_RS10860	COG0018	arginyl-trna synthetase
H4O14_RS10865	COG2032	superoxide dismutase activity
H4O14_RS10870	COG1368	sulfuric ester hydrolase activity
H4O14_RS10875	COG2720	vancomycin resistance protein
H4O14_RS10880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_RS10885	COG0300	oxidoreductase activity
H4O14_RS10900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4O14_RS10905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_RS10910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_RS10930	COG0697	spore germination
H4O14_RS10935	COG0714	Associated with various cellular activities
H4O14_RS10940	COG4548	von Willebrand factor, type A
H4O14_RS10955	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4O14_RS10960	COG2031	fatty acid transporter
H4O14_RS10965	COG1902	pentaerythritol trinitrate reductase activity
H4O14_RS10975	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS10995	COG1657	PFAM Prenyltransferase squalene oxidase
H4O14_RS11005	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_RS11030	COG4975	Glucose uptake
H4O14_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS11060	COG3842	ATPase activity
H4O14_RS11070	COG0561	phosphatase activity
H4O14_RS11080	COG0577	efflux transmembrane transporter activity
H4O14_RS11085	COG1136	(ABC) transporter
H4O14_RS11090	COG0745	RESPONSE REGULATOR receiver
H4O14_RS11095	COG5002	protein histidine kinase activity
H4O14_RS11115	COG4209	transmembrane transport
H4O14_RS11120	COG0395	ABC-type sugar transport system, permease component
H4O14_RS11125	COG1653	transport
H4O14_RS11130	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H4O14_RS11135	COG5578	integral membrane protein
H4O14_RS11150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4O14_RS11165	COG4191	Histidine kinase
H4O14_RS11180	COG0514	ATP-dependent DNA helicase (RecQ)
H4O14_RS11185	COG1164	Oligoendopeptidase f
H4O14_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS11200	COG2329	Antibiotic biosynthesis monooxygenase
H4O14_RS11210	COG2318	DinB family
H4O14_RS11235	COG0733	neurotransmitter:sodium symporter activity
H4O14_RS11240	COG1280	lysine exporter protein (LysE YggA)
H4O14_RS11255	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H4O14_RS11260	COG0351	phosphomethylpyrimidine kinase
H4O14_RS11270	COG1785	Belongs to the alkaline phosphatase family
H4O14_RS11280	COG0657	acetylesterase activity
H4O14_RS11290	COG0076	glutamate decarboxylase activity
H4O14_RS11315	COG1349	DNA-binding transcription factor activity
H4O14_RS11320	COG0561	phosphatase activity
H4O14_RS11325	COG2205	protein histidine kinase activity
H4O14_RS11335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H4O14_RS11345	COG3104	oligopeptide transport
H4O14_RS11350	COG1309	transcriptional regulator
H4O14_RS11355	COG3584	3D domain protein
H4O14_RS11355	COG3583	domain protein
H4O14_RS11360	COG2223	nitrite transmembrane transporter activity
H4O14_RS11365	COG0527	aspartate kinase activity
H4O14_RS11370	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_RS11380	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_RS11400	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS11420	COG3944	biosynthesis protein
H4O14_RS11425	COG0489	protein tyrosine kinase activity
H4O14_RS11440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4O14_RS11445	COG0438	transferase activity, transferring glycosyl groups
H4O14_RS11450	COG1216	Glycosyl transferase, family 2
H4O14_RS11455	COG0438	transferase activity, transferring glycosyl groups
H4O14_RS11460	COG0463	Glycosyl transferase, family 2
H4O14_RS11485	COG1442	glycosyl transferase family 8
H4O14_RS11485	COG1216	Glycosyl transferase, family 2
H4O14_RS11505	COG0110	maltose O-acetyltransferase activity
H4O14_RS11515	COG0463	Glycosyl transferase, family 2
H4O14_RS11515	COG1216	Glycosyl transferase, family 2
H4O14_RS11520	COG1442	glycosyl transferase family 8
H4O14_RS11525	COG1216	Glycosyl transferase, family 2
H4O14_RS11535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4O14_RS11540	COG0110	maltose O-acetyltransferase activity
H4O14_RS11545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4O14_RS11550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4O14_RS11585	COG1132	(ABC) transporter
H4O14_RS11600	COG1132	(ABC) transporter
H4O14_RS11635	COG3340	Belongs to the peptidase S51 family
H4O14_RS11680	COG4191	Histidine kinase
H4O14_RS11690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4O14_RS11690	COG3153	acetyltransferase
H4O14_RS11695	COG0456	acetyltransferase
H4O14_RS11705	COG3773	Cell wall hydrolase
H4O14_RS11710	COG2391	methyltransferase activity
H4O14_RS11730	COG0667	Aldo Keto reductase
H4O14_RS11735	COG0673	inositol 2-dehydrogenase activity
H4O14_RS11745	COG1653	transport
H4O14_RS11750	COG1175	transmembrane transport
H4O14_RS11755	COG0395	ABC-type sugar transport system, permease component
H4O14_RS11760	COG0673	inositol 2-dehydrogenase activity
H4O14_RS11770	COG0673	inositol 2-dehydrogenase activity
H4O14_RS11775	COG0024	Methionine aminopeptidase
H4O14_RS11780	COG2132	Multicopper oxidase
H4O14_RS11795	COG2186	Transcriptional regulator
H4O14_RS11800	COG0277	FAD linked oxidase domain protein
H4O14_RS11805	COG0247	lactate metabolic process
H4O14_RS11810	COG0277	FAD linked oxidase domain protein
H4O14_RS11815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4O14_RS11820	COG0281	malic enzyme
H4O14_RS11825	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4O14_RS11830	COG1414	Transcriptional regulator
H4O14_RS11835	COG1620	l-lactate permease
H4O14_RS11840	COG2169	Transcriptional regulator
H4O14_RS11845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4O14_RS11865	COG0693	protein deglycase activity
H4O14_RS11870	COG3835	regulator
H4O14_RS11875	COG0277	FAD linked oxidase domain protein
H4O14_RS11880	COG0247	lactate metabolic process
H4O14_RS11885	COG0247	lactate metabolic process
H4O14_RS11890	COG1139	Iron-sulfur cluster binding protein
H4O14_RS11895	COG1556	Lactate utilization protein
H4O14_RS11900	COG1914	H( )-stimulated, divalent metal cation uptake system
H4O14_RS11905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H4O14_RS11910	COG1984	allophanate hydrolase subunit 2
H4O14_RS11915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H4O14_RS11920	COG1193	negative regulation of DNA recombination
H4O14_RS11940	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H4O14_RS11945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4O14_RS11955	COG0303	'Molybdopterin
H4O14_RS11960	COG1763	Mo-molybdopterin cofactor biosynthetic process
H4O14_RS11965	COG0314	molybdopterin synthase activity
H4O14_RS11970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H4O14_RS11975	COG3383	formate dehydrogenase (NAD+) activity
H4O14_RS11980	COG2427	Protein of unknown function (DUF1641)
H4O14_RS11985	COG2223	nitrite transmembrane transporter activity
H4O14_RS12000	COG4221	oxidoreductase activity
H4O14_RS12005	COG0789	Transcriptional regulator
H4O14_RS12010	COG0656	L-ascorbic acid biosynthetic process
H4O14_RS12015	COG0110	maltose O-acetyltransferase activity
H4O14_RS12030	COG0640	Transcriptional regulator
H4O14_RS12050	COG0463	Glycosyl transferase, family 2
H4O14_RS12085	COG0442	prolyl-tRNA aminoacylation
H4O14_RS12115	COG5553	Cysteine dioxygenase type I
H4O14_RS12125	COG0322	excinuclease ABC activity
H4O14_RS12135	COG1349	DNA-binding transcription factor activity
H4O14_RS12140	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS12145	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H4O14_RS12155	COG3906	Belongs to the UPF0473 family
H4O14_RS12165	COG4589	Belongs to the CDS family
H4O14_RS12175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O14_RS12185	COG2801	Transposase and inactivated derivatives
H4O14_RS12220	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H4O14_RS12225	COG1492	cobalamin metabolic process
H4O14_RS12230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H4O14_RS12235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O14_RS12240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_RS12245	COG1120	ATPase activity
H4O14_RS12250	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H4O14_RS12255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4O14_RS12265	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H4O14_RS12270	COG0588	phosphoglycerate mutase activity
H4O14_RS12285	COG0640	Transcriptional regulator
H4O14_RS12305	COG2076	Multidrug Resistance protein
H4O14_RS12310	COG2076	Multidrug Resistance protein
H4O14_RS12325	COG0667	Aldo Keto reductase
H4O14_RS12330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4O14_RS12345	COG0747	negative chemotaxis
H4O14_RS12350	COG0601	transmembrane transport
H4O14_RS12355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_RS12360	COG0444	Belongs to the ABC transporter superfamily
H4O14_RS12365	COG1124	(ABC) transporter
H4O14_RS12380	COG0523	cobalamin synthesis protein
H4O14_RS12395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_RS12400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4O14_RS12405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4O14_RS12405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4O14_RS12410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4O14_RS12415	COG0698	ribose 5-phosphate isomerase
H4O14_RS12420	COG1609	Transcriptional regulator
H4O14_RS12425	COG0584	glycerophosphoryl diester phosphodiesterase
H4O14_RS12440	COG1115	amino acid carrier protein
H4O14_RS12450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4O14_RS12455	COG0187	DNA topoisomerase II activity
H4O14_RS12460	COG1832	CoA-binding protein
H4O14_RS12465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H4O14_RS12470	COG2843	Capsule synthesis protein
H4O14_RS12475	COG4841	protein insertion into membrane
H4O14_RS12485	COG0824	Thioesterase
H4O14_RS12505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_RS12510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4O14_RS12530	COG0071	Belongs to the small heat shock protein (HSP20) family
H4O14_RS12555	COG4846	Membrane protein involved in cytochrome C biogenesis
H4O14_RS12560	COG2201	protein-glutamate methylesterase activity
H4O14_RS12565	COG0785	Cytochrome C biogenesis protein
H4O14_RS12580	COG3763	UPF0154 protein
H4O14_RS12595	COG4224	UPF0291 protein
H4O14_RS12600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H4O14_RS12605	COG1388	LysM domain
H4O14_RS12610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4O14_RS12620	COG1620	l-lactate permease
H4O14_RS12625	COG0039	L-malate dehydrogenase activity
H4O14_RS12645	COG0174	glutamine synthetase
H4O14_RS12650	COG0789	Transcriptional regulator
H4O14_RS12655	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H4O14_RS12660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4O14_RS12665	COG2860	membrane
H4O14_RS12670	COG0464	growth
H4O14_RS12680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4O14_RS12690	COG1994	Peptidase M50
H4O14_RS12700	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4O14_RS12705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4O14_RS12710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H4O14_RS12720	COG4550	Control of competence regulator ComK, YlbF/YmcA
H4O14_RS12725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4O14_RS12730	COG0156	8-amino-7-oxononanoate synthase activity
H4O14_RS12735	COG1063	alcohol dehydrogenase
H4O14_RS12740	COG1013	pyruvate-flavodoxin oxidoreductase activity
H4O14_RS12745	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H4O14_RS12745	COG0674	pyruvate-flavodoxin oxidoreductase activity
H4O14_RS12755	COG2359	stage V sporulation protein S
H4O14_RS12760	COG1692	metallophosphoesterase
H4O14_RS12765	COG1418	mRNA catabolic process
H4O14_RS12770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4O14_RS12775	COG1546	Belongs to the CinA family
H4O14_RS12775	COG1058	Belongs to the CinA family
H4O14_RS12780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H4O14_RS12785	COG1426	Protein conserved in bacteria
H4O14_RS12805	COG0300	oxidoreductase activity
H4O14_RS12810	COG0612	Peptidase, M16
H4O14_RS12815	COG0612	Peptidase, M16
H4O14_RS12825	COG1079	Belongs to the binding-protein-dependent transport system permease family
H4O14_RS12830	COG4603	Belongs to the binding-protein-dependent transport system permease family
H4O14_RS12835	COG3845	ABC transporter
H4O14_RS12840	COG1744	ABC transporter substrate-binding protein PnrA-like
H4O14_RS12845	COG2188	Transcriptional regulator
H4O14_RS12850	COG4980	gas vesicle protein
H4O14_RS12850	COG1674	ftsk spoiiie
H4O14_RS12860	COG0740	serine-type endopeptidase activity
H4O14_RS12865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H4O14_RS12880	COG0527	aspartate kinase activity
H4O14_RS12885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4O14_RS12890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4O14_RS12895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4O14_RS12900	COG1873	PFAM PRC-barrel domain
H4O14_RS12905	COG0612	Peptidase, M16
H4O14_RS12910	COG0726	polysaccharide deacetylase
H4O14_RS12915	COG1185	polyribonucleotide nucleotidyltransferase activity
H4O14_RS12925	COG0196	riboflavin kinase activity
H4O14_RS12930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H4O14_RS12935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H4O14_RS12940	COG1550	Protein conserved in bacteria
H4O14_RS12950	COG1358	cellular component organization or biogenesis
H4O14_RS12955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H4O14_RS12965	COG0779	Required for maturation of 30S ribosomal subunits
H4O14_RS12970	COG2176	DNA-directed DNA polymerase activity
H4O14_RS12975	COG0442	prolyl-tRNA aminoacylation
H4O14_RS12980	COG0750	zinc metalloprotease
H4O14_RS12985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4O14_RS12990	COG4589	Belongs to the CDS family
H4O14_RS12995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4O14_RS13000	COG0233	cytoplasmic translational termination
H4O14_RS13005	COG0528	UMP kinase activity
H4O14_RS13015	COG0052	Belongs to the universal ribosomal protein uS2 family
H4O14_RS13025	COG1191	sigma factor activity
H4O14_RS13030	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H4O14_RS13035	COG1776	CheC inhibitor of MCP methylation
H4O14_RS13040	COG0835	chemotaxis
H4O14_RS13045	COG2198	Histidine kinase
H4O14_RS13045	COG0643	Histidine kinase
H4O14_RS13050	COG2201	protein-glutamate methylesterase activity
H4O14_RS13055	COG0455	bacterial-type flagellum organization
H4O14_RS13060	COG1419	protein localization to endoplasmic reticulum
H4O14_RS13065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4O14_RS13070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4O14_RS13075	COG1684	flagellar biosynthetic protein fliR
H4O14_RS13080	COG1987	bacterial-type flagellum assembly
H4O14_RS13085	COG1338	Plays a role in the flagellum-specific transport system
H4O14_RS13090	COG3190	flagellar
H4O14_RS13095	COG2201	protein-glutamate methylesterase activity
H4O14_RS13100	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4O14_RS13100	COG1776	CheC inhibitor of MCP methylation
H4O14_RS13105	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4O14_RS13110	COG1580	Controls the rotational direction of flagella during chemotaxis
H4O14_RS13115	COG1582	Flagellar protein (FlbD)
H4O14_RS13120	COG4786	Flagellar basal body rod
H4O14_RS13130	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H4O14_RS13135	COG3144	bacterial-type flagellum assembly
H4O14_RS13145	COG2882	bacterial-type flagellum organization
H4O14_RS13150	COG1157	protein secretion by the type III secretion system
H4O14_RS13155	COG1317	bacterial-type flagellum organization
H4O14_RS13160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4O14_RS13165	COG1766	The M ring may be actively involved in energy transduction
H4O14_RS13170	COG1677	Flagellar hook-basal body complex protein FliE
H4O14_RS13175	COG1558	bacterial-type flagellum-dependent cell motility
H4O14_RS13180	COG1815	bacterial-type flagellum-dependent cell motility
H4O14_RS13185	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H4O14_RS13190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H4O14_RS13200	COG4974	Belongs to the 'phage' integrase family
H4O14_RS13205	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H4O14_RS13210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4O14_RS13215	COG0758	DNA mediated transformation
H4O14_RS13220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4O14_RS13225	COG0045	succinate-CoA ligase (ADP-forming) activity
H4O14_RS13230	COG2257	FlhB HrpN YscU SpaS Family
H4O14_RS13255	COG0335	large ribosomal subunit rRNA binding
H4O14_RS13260	COG0336	Belongs to the RNA methyltransferase TrmD family
H4O14_RS13265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4O14_RS13275	COG1837	Belongs to the UPF0109 family
H4O14_RS13285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4O14_RS13295	COG0552	protein localization to endoplasmic reticulum
H4O14_RS13300	COG1196	nuclear chromosome segregation
H4O14_RS13310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4O14_RS13315	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS13320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4O14_RS13325	COG0416	fatty acid biosynthetic process
H4O14_RS13330	COG1349	DNA-binding transcription factor activity
H4O14_RS13335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4O14_RS13340	COG1760	l-serine dehydratase
H4O14_RS13345	COG1760	l-serine dehydratase
H4O14_RS13350	COG1461	Dihydroxyacetone kinase
H4O14_RS13355	COG1302	Protein conserved in bacteria
H4O14_RS13370	COG1564	THIamine pyrophosphokinase
H4O14_RS13375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4O14_RS13380	COG1162	GTPase activity
H4O14_RS13385	COG2815	serine threonine protein kinase
H4O14_RS13385	COG0515	serine threonine protein kinase
H4O14_RS13390	COG0631	protein serine/threonine phosphatase activity
H4O14_RS13400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4O14_RS13400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4O14_RS13415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4O14_RS13420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4O14_RS13425	COG1758	RNA polymerase activity
H4O14_RS13430	COG0194	GDP metabolic process
H4O14_RS13440	COG1561	YicC-like family, N-terminal region
H4O14_RS13445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4O14_RS13470	COG0529	Catalyzes the synthesis of activated sulfate
H4O14_RS13480	COG0306	phosphate transporter
H4O14_RS13505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H4O14_RS13510	COG0284	orotidine-5'-phosphate decarboxylase activity
H4O14_RS13515	COG0167	dihydroorotate dehydrogenase activity
H4O14_RS13520	COG0543	2 iron, 2 sulfur cluster binding
H4O14_RS13525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4O14_RS13530	COG0505	Belongs to the CarA family
H4O14_RS13535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4O14_RS13550	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H4O14_RS13555	COG0564	pseudouridine synthase activity
H4O14_RS13565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4O14_RS13570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H4O14_RS13575	COG3599	regulation of cell shape
H4O14_RS13580	COG2302	S4 RNA-binding domain
H4O14_RS13585	COG0762	integral membrane protein
H4O14_RS13590	COG1799	cell septum assembly
H4O14_RS13595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4O14_RS13600	COG1496	oxidoreductase activity
H4O14_RS13605	COG1873	PFAM PRC-barrel domain
H4O14_RS13610	COG0701	Predicted permease
H4O14_RS13615	COG3689	TIGRFAM TIGR03943 family protein
H4O14_RS13620	COG1191	sigma factor activity
H4O14_RS13625	COG1191	sigma factor activity
H4O14_RS13635	COG1404	Belongs to the peptidase S8 family
H4O14_RS13635	COG4412	M6 family metalloprotease domain protein
H4O14_RS13640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4O14_RS13645	COG0849	cell division
H4O14_RS13650	COG3856	small basic protein
H4O14_RS13655	COG3879	Bacterial protein of unknown function (DUF881)
H4O14_RS13660	COG3879	Bacterial protein of unknown function (DUF881)
H4O14_RS13665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4O14_RS13670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H4O14_RS13680	COG0772	Belongs to the SEDS family
H4O14_RS13685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H4O14_RS13690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4O14_RS13695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4O14_RS13700	COG0768	penicillin binding
H4O14_RS13705	COG0768	penicillin binding
H4O14_RS13710	COG4839	cell division protein FtsL
H4O14_RS13715	COG0275	rRNA processing
H4O14_RS13720	COG2001	Belongs to the MraZ family
H4O14_RS13725	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H4O14_RS13735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4O14_RS13740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4O14_RS13745	COG0511	ligase activity, forming carbon-carbon bonds
H4O14_RS13750	COG0439	Biotin carboxylase
H4O14_RS13755	COG0454	-acetyltransferase
H4O14_RS13765	COG1024	Enoyl-CoA hydratase
H4O14_RS13770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H4O14_RS13775	COG1399	metal-binding, possibly nucleic acid-binding protein
H4O14_RS13780	COG1323	Belongs to the UPF0348 family
H4O14_RS13790	COG3480	Lon protease (S16) C-terminal proteolytic domain
H4O14_RS13795	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4O14_RS13800	COG3314	Sporulation integral membrane protein YlbJ
H4O14_RS13805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4O14_RS13810	COG0742	ribosomal rna small subunit methyltransferase
H4O14_RS13825	COG3679	Belongs to the UPF0342 family
H4O14_RS13850	COG2340	Cysteine-rich secretory protein family
H4O14_RS13855	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H4O14_RS13865	COG0628	permease
H4O14_RS13880	COG3336	cytochrome c oxidase
H4O14_RS13890	COG1845	cytochrome c oxidase, subunit III
H4O14_RS13895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4O14_RS13900	COG2010	Cytochrome c
H4O14_RS13900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4O14_RS13910	COG1612	heme a metabolic process
H4O14_RS13915	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H4O14_RS13920	COG0772	Belongs to the SEDS family
H4O14_RS13925	COG4838	Belongs to the UPF0358 family
H4O14_RS13930	COG2066	Belongs to the glutaminase family
H4O14_RS13935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4O14_RS13940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H4O14_RS13955	COG4896	Protein conserved in bacteria
H4O14_RS13975	COG1217	gtp-binding protein TYPA
H4O14_RS13990	COG0483	inositol monophosphate 1-phosphatase activity
H4O14_RS14000	COG4493	Belongs to the UPF0637 family
H4O14_RS14005	COG4476	Belongs to the UPF0223 family
H4O14_RS14020	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_RS14030	COG0410	ABC transporter
H4O14_RS14055	COG1024	Enoyl-CoA hydratase
H4O14_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS14065	COG2045	Belongs to the ComB family
H4O14_RS14080	COG1024	Enoyl-CoA hydratase
H4O14_RS14085	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_RS14095	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_RS14100	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS14105	COG0183	Belongs to the thiolase family
H4O14_RS14110	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS14115	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS14120	COG1982	Orn Lys Arg decarboxylase major
H4O14_RS14150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_RS14155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4O14_RS14160	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4O14_RS14165	COG0022	dehydrogenase e1 component
H4O14_RS14170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4O14_RS14185	COG0242	peptide deformylase activity
H4O14_RS14190	COG0561	phosphatase activity
H4O14_RS14200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H4O14_RS14210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4O14_RS14220	COG0569	domain protein
H4O14_RS14225	COG1294	oxidase, subunit
H4O14_RS14230	COG1271	oxidase subunit
H4O14_RS14240	COG3852	Histidine kinase
H4O14_RS14245	COG4637	Psort location Cytoplasmic, score
H4O14_RS14250	COG3180	Ammonia monooxygenase
H4O14_RS14255	COG1607	acyl-coa hydrolase
H4O14_RS14260	COG1077	Cell shape determining protein MreB Mrl
H4O14_RS14265	COG2720	vancomycin resistance protein
H4O14_RS14270	COG0488	(ABC) transporter
H4O14_RS14280	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS14285	COG2309	aminopeptidase activity
H4O14_RS14295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4O14_RS14300	COG0488	(ABC) transporter
H4O14_RS14320	COG0681	Belongs to the peptidase S26 family
H4O14_RS14340	COG1136	(ABC) transporter
H4O14_RS14345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4O14_RS14355	COG1132	(ABC) transporter
H4O14_RS14360	COG1132	(ABC) transporter
H4O14_RS14365	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4O14_RS14380	COG0110	maltose O-acetyltransferase activity
H4O14_RS14390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4O14_RS14395	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_RS14405	COG3835	regulator
H4O14_RS14430	COG0493	'glutamate synthase
H4O14_RS14470	COG1278	Cold shock
H4O14_RS14475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_RS14480	COG0450	alkyl hydroperoxide reductase
H4O14_RS14485	COG0668	transmembrane transport
H4O14_RS14495	COG1473	amidohydrolase
H4O14_RS14505	COG0716	FMN binding
H4O14_RS14515	COG0716	FMN binding
H4O14_RS14520	COG0583	DNA-binding transcription factor activity
H4O14_RS14535	COG0477	Major facilitator Superfamily
H4O14_RS14540	COG0517	IMP dehydrogenase activity
H4O14_RS14550	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H4O14_RS14560	COG4703	Protein of unknown function (DUF1797)
H4O14_RS14590	COG2200	EAL domain
H4O14_RS14595	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS14600	COG1408	metallophosphoesterase
H4O14_RS14605	COG5001	Diguanylate cyclase
H4O14_RS14605	COG3300	MHYT domain
H4O14_RS14610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4O14_RS14615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4O14_RS14625	COG0248	Ppx GppA phosphatase
H4O14_RS14630	COG1376	ErfK ybiS ycfS ynhG family protein
H4O14_RS14635	COG2814	Major facilitator Superfamily
H4O14_RS14655	COG0835	chemotaxis
H4O14_RS14655	COG0784	Response regulator, receiver
H4O14_RS14675	COG5002	protein histidine kinase activity
H4O14_RS14700	COG0598	Magnesium transport protein CorA
H4O14_RS14705	COG0436	Aminotransferase
H4O14_RS14710	COG4191	Histidine kinase
H4O14_RS14730	COG0768	penicillin binding
H4O14_RS14735	COG2340	Cysteine-rich secretory protein family
H4O14_RS14740	COG0456	acetyltransferase
H4O14_RS14745	COG2084	Dehydrogenase
H4O14_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS14765	COG1533	DNA photolyase activity
H4O14_RS14775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4O14_RS14780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4O14_RS14785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_RS14785	COG2190	(PTS) system
H4O14_RS14785	COG1263	PTS System
H4O14_RS14790	COG3711	transcriptional antiterminator
H4O14_RS14805	COG0561	phosphatase activity
H4O14_RS14810	COG3300	MHYT domain
H4O14_RS14810	COG5001	Diguanylate cyclase
H4O14_RS14825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H4O14_RS14850	COG1525	nuclease
H4O14_RS14855	COG0006	proline dipeptidase activity
H4O14_RS14875	COG2217	Heavy metal translocating P-type atpase
H4O14_RS14885	COG3209	COG3209 Rhs family protein
H4O14_RS14895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4O14_RS14900	COG2244	polysaccharide biosynthetic process
H4O14_RS14920	COG3773	Cell wall hydrolase
H4O14_RS14930	COG5002	protein histidine kinase activity
H4O14_RS14950	COG0702	epimerase
H4O14_RS14960	COG4873	Protein conserved in bacteria
H4O14_RS14965	COG0456	acetyltransferase
H4O14_RS14970	COG1388	LysM domain
H4O14_RS14970	COG3584	3D domain protein
H4O14_RS14980	COG2135	peptidase activity
H4O14_RS15000	COG1278	Cold shock
H4O14_RS15005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4O14_RS15015	COG0720	synthase
H4O14_RS15020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4O14_RS15040	COG1253	flavin adenine dinucleotide binding
H4O14_RS15050	COG3949	Membrane
H4O14_RS15055	COG0542	response to heat
H4O14_RS15070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H4O14_RS15075	COG1360	Flagellar Motor Protein
H4O14_RS15080	COG1846	Transcriptional regulator
H4O14_RS15085	COG0737	Belongs to the 5'-nucleotidase family
H4O14_RS15090	COG3852	Histidine kinase
H4O14_RS15095	COG0667	Aldo Keto reductase
H4O14_RS15110	COG0753	catalase activity
H4O14_RS15135	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H4O14_RS15140	COG0235	Class ii aldolase
H4O14_RS15145	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
H4O14_RS15150	COG1850	ribulose-bisphosphate carboxylase activity
H4O14_RS15155	COG0436	Aminotransferase
H4O14_RS15160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4O14_RS15165	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H4O14_RS15170	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H4O14_RS15190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4O14_RS15195	COG5002	protein histidine kinase activity
H4O14_RS15200	COG3594	Acyltransferase
H4O14_RS15240	COG0412	Dienelactone hydrolase
H4O14_RS15270	COG1388	LysM domain
H4O14_RS15290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4O14_RS15295	COG0598	Magnesium transport protein CorA
H4O14_RS15300	COG1113	amino acid transport
H4O14_RS15305	COG0598	Magnesium transport protein CorA
H4O14_RS15315	COG0737	Belongs to the 5'-nucleotidase family
H4O14_RS15315	COG4085	toxin activity
H4O14_RS15315	COG1525	nuclease
H4O14_RS15325	COG0768	penicillin binding
H4O14_RS15330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H4O14_RS15335	COG0501	Belongs to the peptidase M48B family
H4O14_RS15355	COG1191	sigma factor activity
H4O14_RS15360	COG0861	Integral membrane protein TerC family
H4O14_RS15365	COG0586	Pfam SNARE associated Golgi protein
H4O14_RS15380	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H4O14_RS15385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4O14_RS15390	COG3285	dna ligase
H4O14_RS15390	COG1793	dna ligase
H4O14_RS15395	COG1846	Transcriptional regulator
H4O14_RS15405	COG0746	molybdenum cofactor guanylyltransferase activity
H4O14_RS15410	COG3541	Predicted nucleotidyltransferase
H4O14_RS15430	COG0789	Transcriptional regulator
H4O14_RS15435	COG0840	transmembrane signaling receptor activity
H4O14_RS15440	COG1764	response to oxidative stress
H4O14_RS15445	COG1846	Transcriptional regulator
H4O14_RS15460	COG1609	Transcriptional regulator
H4O14_RS15470	COG1082	Xylose isomerase domain protein TIM barrel
H4O14_RS15475	COG0673	inositol 2-dehydrogenase activity
H4O14_RS15480	COG0673	inositol 2-dehydrogenase activity
H4O14_RS15485	COG1595	DNA-templated transcription, initiation
H4O14_RS15505	COG2602	Beta-lactamase
H4O14_RS15530	COG2404	hydrolase activity, acting on ester bonds
H4O14_RS15540	COG2323	membrane
H4O14_RS15545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4O14_RS15570	COG0642	Histidine kinase
H4O14_RS15575	COG0745	RESPONSE REGULATOR receiver
H4O14_RS15580	COG1929	Belongs to the glycerate kinase type-1 family
H4O14_RS15585	COG2610	gluconate transmembrane transporter activity
H4O14_RS15590	COG3835	regulator
H4O14_RS15595	COG1585	Membrane protein implicated in regulation of membrane protease activity
H4O14_RS15600	COG2268	Band 7 protein
H4O14_RS15615	COG3212	peptidase
H4O14_RS15620	COG5002	protein histidine kinase activity
H4O14_RS15620	COG3850	Histidine kinase
H4O14_RS15625	COG0745	RESPONSE REGULATOR receiver
H4O14_RS15630	COG0584	glycerophosphoryl diester phosphodiesterase
H4O14_RS15640	COG4335	DNA alkylation repair
H4O14_RS15650	COG3876	Protein conserved in bacteria
H4O14_RS15655	COG1472	Belongs to the glycosyl hydrolase 3 family
H4O14_RS15660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4O14_RS15670	COG1263	PTS System
H4O14_RS15670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_RS15675	COG1737	Transcriptional regulator
H4O14_RS15680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4O14_RS15685	COG2304	oxidoreductase activity
H4O14_RS15690	COG2310	stress, protein
H4O14_RS15695	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_RS15705	COG1404	Belongs to the peptidase S8 family
H4O14_RS15745	COG1116	anion transmembrane transporter activity
H4O14_RS15745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_RS15755	COG0488	(ABC) transporter
H4O14_RS15760	COG0723	plastoquinol--plastocyanin reductase activity
H4O14_RS15760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O14_RS15765	COG2824	Alkylphosphonate utilization operon protein PhnA
H4O14_RS15770	COG1278	Cold shock
H4O14_RS15785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4O14_RS15790	COG2188	Transcriptional regulator
H4O14_RS15795	COG0363	glucosamine-6-phosphate deaminase activity
H4O14_RS15800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4O14_RS15805	COG1263	PTS System
H4O14_RS15805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_RS15820	COG2271	Major facilitator Superfamily
H4O14_RS15825	COG0277	FAD linked oxidase domain protein
H4O14_RS15830	COG3871	stress protein (general stress protein 26)
H4O14_RS15865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O14_RS15870	COG0765	amino acid transport
H4O14_RS15875	COG1126	abc transporter atp-binding protein
H4O14_RS15880	COG2364	Membrane
H4O14_RS15885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4O14_RS15895	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4O14_RS15920	COG1174	glycine betaine transport
H4O14_RS15925	COG1125	glycine betaine transport
H4O14_RS15925	COG0517	IMP dehydrogenase activity
H4O14_RS15935	COG1363	Peptidase, m42
H4O14_RS15945	COG1834	amidinotransferase
H4O14_RS15950	COG4191	Histidine kinase
H4O14_RS15960	COG4608	Belongs to the ABC transporter superfamily
H4O14_RS15965	COG0791	NLP P60 protein
H4O14_RS15970	COG4948	Mandelate Racemase Muconate Lactonizing
H4O14_RS15975	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4O14_RS15980	COG4166	transmembrane transport
H4O14_RS15985	COG0444	Belongs to the ABC transporter superfamily
H4O14_RS15990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_RS15995	COG0601	transmembrane transport
H4O14_RS16000	COG2362	D-Aminopeptidase
H4O14_RS16005	COG2050	protein possibly involved in aromatic compounds catabolism
H4O14_RS16010	COG1024	Enoyl-CoA hydratase
H4O14_RS16020	COG0183	Belongs to the thiolase family
H4O14_RS16025	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS16030	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_RS16035	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_RS16040	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_RS16045	COG2814	Major facilitator Superfamily
H4O14_RS16050	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS16060	COG1595	DNA-templated transcription, initiation
H4O14_RS16065	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H4O14_RS16075	COG2322	membrane
H4O14_RS16080	COG3829	transcription factor binding
H4O14_RS16080	COG3290	protein histidine kinase activity
H4O14_RS16090	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS16095	COG0604	alcohol dehydrogenase
H4O14_RS16105	COG1126	abc transporter atp-binding protein
H4O14_RS16110	COG0765	amino acid transport
H4O14_RS16130	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS16135	COG2706	6-phosphogluconolactonase activity
H4O14_RS16140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4O14_RS16145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_RS16160	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_RS16165	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H4O14_RS16170	COG1131	(ABC) transporter
H4O14_RS16190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4O14_RS16210	COG1131	(ABC) transporter
H4O14_RS16215	COG1725	Transcriptional regulator
H4O14_RS16220	COG4257	antibiotic catabolic process
H4O14_RS16225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4O14_RS16225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4O14_RS16230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4O14_RS16235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4O14_RS16245	COG2186	Transcriptional regulator
H4O14_RS16250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H4O14_RS16260	COG2721	sulfolactate sulfo-lyase activity
H4O14_RS16265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4O14_RS16280	COG0613	PHP domain protein
H4O14_RS16285	COG4778	phosphonate C-P lyase system protein PhnL
H4O14_RS16295	COG3454	Phosphonate metabolism
H4O14_RS16300	COG4107	phosphonate C-P lyase system protein PhnK
H4O14_RS16305	COG3627	carbon phosphorus lyase activity
H4O14_RS16325	COG3639	organic phosphonate transmembrane transporter activity
H4O14_RS16330	COG3639	organic phosphonate transmembrane transporter activity
H4O14_RS16335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H4O14_RS16345	COG2188	Transcriptional regulator
H4O14_RS16355	COG5578	integral membrane protein
H4O14_RS16360	COG0673	inositol 2-dehydrogenase activity
H4O14_RS16375	COG0395	ABC-type sugar transport system, permease component
H4O14_RS16390	COG1175	transmembrane transport
H4O14_RS16400	COG0673	inositol 2-dehydrogenase activity
H4O14_RS16420	COG1940	carbohydrate kinase activity
H4O14_RS16425	COG1357	PFAM Pentapeptide repeats (8 copies)
H4O14_RS16430	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H4O14_RS16440	COG1476	TRANSCRIPTIONal
H4O14_RS16450	COG0596	Alpha beta hydrolase
H4O14_RS16460	COG5444	nuclease activity
H4O14_RS16480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_RS16485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4O14_RS16490	COG1061	Type III restriction enzyme res subunit
H4O14_RS16500	COG0494	nUDIX hydrolase
H4O14_RS16515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H4O14_RS16545	COG3226	Transcriptional regulator
H4O14_RS16555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4O14_RS16565	COG0656	L-ascorbic acid biosynthetic process
H4O14_RS16570	COG2814	Major facilitator Superfamily
H4O14_RS16575	COG1733	regulation of RNA biosynthetic process
H4O14_RS16590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H4O14_RS16595	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H4O14_RS16605	COG1587	Uroporphyrinogen-III synthase
H4O14_RS16630	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS16635	COG1312	Catalyzes the dehydration of D-mannonate
H4O14_RS16640	COG1904	glucuronate isomerase
H4O14_RS16670	COG0800	Aldolase
H4O14_RS16675	COG1609	Transcriptional regulator
H4O14_RS16685	COG1349	DNA-binding transcription factor activity
H4O14_RS16695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4O14_RS16700	COG0805	protein transport
H4O14_RS16710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H4O14_RS16715	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_RS16825	COG4974	Belongs to the 'phage' integrase family
H4O14_RS16835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4O14_RS16850	COG2358	TRAP transporter, solute receptor (TAXI family
H4O14_RS16860	COG3832	glyoxalase III activity
H4O14_RS16870	COG1063	alcohol dehydrogenase
H4O14_RS16890	COG3764	Sortase (surface protein transpeptidase)
H4O14_RS16900	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_RS16905	COG5577	PFAM Coat F domain
H4O14_RS16945	COG0861	Integral membrane protein TerC family
H4O14_RS16975	COG4682	membrane
H4O14_RS16980	COG0726	polysaccharide deacetylase
H4O14_RS16985	COG0726	polysaccharide deacetylase
H4O14_RS17015	COG1846	Transcriptional regulator
H4O14_RS17020	COG0531	amino acid
H4O14_RS17030	COG1607	acyl-coa hydrolase
H4O14_RS17070	COG2211	Major facilitator Superfamily
H4O14_RS17090	COG0456	acetyltransferase
H4O14_RS17105	COG2197	response regulator
H4O14_RS17110	COG4585	Histidine kinase
H4O14_RS17115	COG3239	Fatty acid desaturase
H4O14_RS17120	COG2318	DinB family
H4O14_RS17130	COG2514	catechol 2,3-dioxygenase activity
H4O14_RS17150	COG0697	spore germination
H4O14_RS17155	COG0772	Belongs to the SEDS family
H4O14_RS17165	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H4O14_RS17180	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_RS17190	COG0772	Belongs to the SEDS family
H4O14_RS17195	COG0586	Pfam SNARE associated Golgi protein
H4O14_RS17200	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_RS17215	COG2207	Transcriptional regulator
H4O14_RS17215	COG3708	Transcriptional regulator
H4O14_RS17220	COG0588	phosphoglycerate mutase activity
H4O14_RS17245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4O14_RS17255	COG1917	Cupin 2, conserved barrel domain protein
H4O14_RS17255	COG4977	sequence-specific DNA binding
H4O14_RS17260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4O14_RS17295	COG0626	cystathionine gamma-synthase activity
H4O14_RS17300	COG0626	cystathionine gamma-synthase activity
H4O14_RS17310	COG2382	esterase
H4O14_RS17315	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H4O14_RS17320	COG2153	protein acetylation
H4O14_RS17330	COG2323	membrane
H4O14_RS17345	COG0210	DNA helicase
H4O14_RS17400	COG0438	transferase activity, transferring glycosyl groups
H4O14_RS17405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4O14_RS17410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4O14_RS17415	COG0438	transferase activity, transferring glycosyl groups
H4O14_RS17425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4O14_RS17430	COG0438	transferase activity, transferring glycosyl groups
H4O14_RS17435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4O14_RS17450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H4O14_RS17455	COG2733	membrane
H4O14_RS17460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4O14_RS17470	COG2104	thiamine diphosphate biosynthetic process
H4O14_RS17475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O14_RS17480	COG0352	thiamine-phosphate diphosphorylase activity
H4O14_RS17485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H4O14_RS17490	COG0475	glutathione-regulated potassium exporter activity
H4O14_RS17490	COG0569	domain protein
H4O14_RS17495	COG2239	Acts as a magnesium transporter
H4O14_RS17500	COG0772	Belongs to the SEDS family
H4O14_RS17505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4O14_RS17510	COG0564	pseudouridine synthase activity
H4O14_RS17515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4O14_RS17520	COG2357	RelA SpoT domain protein
H4O14_RS17530	COG4116	CYTH
H4O14_RS17535	COG0741	lytic transglycosylase activity
H4O14_RS17540	COG2346	COG2346, Truncated hemoglobins
H4O14_RS17545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4O14_RS17555	COG1164	Oligoendopeptidase f
H4O14_RS17565	COG4469	Competence protein
H4O14_RS17570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4O14_RS17575	COG4862	establishment of competence for transformation
H4O14_RS17580	COG0861	Integral membrane protein TerC family
H4O14_RS17585	COG1393	Belongs to the ArsC family
H4O14_RS17590	COG0456	acetyltransferase
H4O14_RS17605	COG4608	Belongs to the ABC transporter superfamily
H4O14_RS17610	COG0444	Belongs to the ABC transporter superfamily
H4O14_RS17615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_RS17620	COG0601	transmembrane transport
H4O14_RS17635	COG0180	Tryptophanyl-tRNA synthetase
H4O14_RS17645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_RS17650	COG0601	transmembrane transport
H4O14_RS17660	COG4608	Belongs to the ABC transporter superfamily
H4O14_RS17665	COG0444	Belongs to the ABC transporter superfamily
H4O14_RS17670	COG5504	Zn-dependent protease
H4O14_RS17675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4O14_RS17680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4O14_RS17700	COG1744	ABC transporter substrate-binding protein PnrA-like
H4O14_RS17710	COG2267	carboxylic ester hydrolase activity
H4O14_RS17725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4O14_RS17730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4O14_RS17735	COG0505	Belongs to the CarA family
H4O14_RS17745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4O14_RS17750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H4O14_RS17755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H4O14_RS17760	COG2151	metal-sulfur cluster biosynthetic enzyme
H4O14_RS17765	COG1073	alpha beta
H4O14_RS17770	COG0561	phosphatase activity
H4O14_RS17790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_RS17795	COG1307	EDD domain protein, DegV family
H4O14_RS17805	COG0840	transmembrane signaling receptor activity
H4O14_RS17810	COG1744	ABC transporter substrate-binding protein PnrA-like
H4O14_RS17815	COG2996	Protein conserved in bacteria
H4O14_RS17825	COG1666	GTP binding
H4O14_RS17830	COG0646	methionine synthase
H4O14_RS17830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4O14_RS17835	COG1410	methionine synthase
H4O14_RS17835	COG0646	methionine synthase
H4O14_RS17840	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS17855	COG1227	inorganic diphosphatase activity
H4O14_RS17885	COG1874	Beta-galactosidase
H4O14_RS17885	COG0366	Alpha amylase catalytic
H4O14_RS17890	COG3833	ABC-type maltose transport systems, permease component
H4O14_RS17895	COG1175	transmembrane transport
H4O14_RS17900	COG2182	Extracellular solute-binding protein
H4O14_RS17910	COG1113	amino acid transport
H4O14_RS17920	COG2207	Transcriptional regulator
H4O14_RS17920	COG1917	Cupin 2, conserved barrel domain protein
H4O14_RS17925	COG0534	Mate efflux family protein
H4O14_RS17930	COG0004	ammonium transporteR
H4O14_RS17935	COG1464	Belongs to the NlpA lipoprotein family
H4O14_RS17955	COG1562	ergosterol biosynthetic process
H4O14_RS17965	COG0367	asparagine synthase
H4O14_RS17980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4O14_RS17990	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4O14_RS17995	COG0084	hydrolase, TatD family'
H4O14_RS18005	COG2311	Membrane
H4O14_RS18010	COG1510	regulation of RNA biosynthetic process
H4O14_RS18015	COG1125	glycine betaine transport
H4O14_RS18015	COG0517	IMP dehydrogenase activity
H4O14_RS18020	COG1174	glycine betaine transport
H4O14_RS18025	COG1732	Glycine betaine
H4O14_RS18030	COG1174	glycine betaine transport
H4O14_RS18060	COG1609	Transcriptional regulator
H4O14_RS18065	COG3459	Glycosyltransferase 36 associated
H4O14_RS18075	COG1653	transport
H4O14_RS18085	COG0395	ABC-type sugar transport system, permease component
H4O14_RS18120	COG0419	ATPase involved in DNA repair
H4O14_RS18125	COG0420	3'-5' exonuclease activity
H4O14_RS18130	COG1074	ATP-dependent DNA helicase activity
H4O14_RS18135	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H4O14_RS18140	COG2814	Major facilitator Superfamily
H4O14_RS18145	COG0681	Belongs to the peptidase S26 family
H4O14_RS18150	COG0398	Pfam SNARE associated Golgi protein
H4O14_RS18160	COG4903	ComK protein
H4O14_RS18170	COG2224	Isocitrate lyase
H4O14_RS18175	COG0501	Belongs to the peptidase M48B family
H4O14_RS18185	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H4O14_RS18190	COG1396	sequence-specific DNA binding
H4O14_RS18200	COG1024	Enoyl-CoA hydratase
H4O14_RS18205	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_RS18240	COG0095	Lipoate-protein ligase
H4O14_RS18245	COG1234	tRNA 3'-trailer cleavage
H4O14_RS18260	COG1940	carbohydrate kinase activity
H4O14_RS18260	COG1846	Transcriptional regulator
H4O14_RS18270	COG0673	inositol 2-dehydrogenase activity
H4O14_RS18280	COG0753	catalase activity
H4O14_RS18305	COG0395	ABC-type sugar transport system, permease component
H4O14_RS18325	COG0395	ABC-type sugar transport system, permease component
H4O14_RS18355	COG5578	integral membrane protein
H4O14_RS18365	COG1609	Transcriptional regulator
H4O14_RS18370	COG1511	domain protein
H4O14_RS18375	COG1309	transcriptional regulator
H4O14_RS18380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H4O14_RS18385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H4O14_RS18390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H4O14_RS18395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_RS18400	COG2329	Antibiotic biosynthesis monooxygenase
H4O14_RS18405	COG3069	C4-dicarboxylate transmembrane transporter activity
H4O14_RS18410	COG0671	phosphoesterase, PA-phosphatase related
H4O14_RS18415	COG1473	amidohydrolase
H4O14_RS18425	COG4473	ABC transporter
H4O14_RS18430	COG1131	(ABC) transporter
H4O14_RS18435	COG0537	adenosine 5'-monophosphoramidase activity
H4O14_RS18440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4O14_RS18455	COG4980	gas vesicle protein
H4O14_RS18460	COG1846	Transcriptional regulator
H4O14_RS18490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4O14_RS18500	COG3481	metal-dependent phosphohydrolase, HD sub domain
H4O14_RS18505	COG2814	Major facilitator Superfamily
H4O14_RS18510	COG4717	serine-type aminopeptidase activity
H4O14_RS18515	COG0420	3'-5' exonuclease activity
H4O14_RS18520	COG1668	transmembrane transport
H4O14_RS18525	COG4152	abc transporter atp-binding protein
H4O14_RS18535	COG1024	Enoyl-CoA hydratase
H4O14_RS18540	COG0183	Belongs to the thiolase family
H4O14_RS18545	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_RS18550	COG1960	acyl-CoA dehydrogenase activity
H4O14_RS18585	COG1605	Chorismate mutase
H4O14_RS18585	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H4O14_RS18600	COG0529	Catalyzes the synthesis of activated sulfate
H4O14_RS18630	COG1113	amino acid transport
H4O14_RS18635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4O14_RS18640	COG0561	phosphatase activity
H4O14_RS18655	COG0561	phosphatase activity
H4O14_RS18660	COG3679	Belongs to the UPF0342 family
H4O14_RS18670	COG0189	ligase activity
H4O14_RS18690	COG2508	Transcriptional regulator
H4O14_RS18695	COG3842	ATPase activity
H4O14_RS18715	COG1126	abc transporter atp-binding protein
H4O14_RS18720	COG0765	amino acid transport
H4O14_RS18725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O14_RS18730	COG0702	epimerase
H4O14_RS18735	COG1132	(ABC) transporter
H4O14_RS18740	COG1132	(ABC) transporter
H4O14_RS18755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_RS18760	COG0589	response to stress
H4O14_RS18765	COG0840	transmembrane signaling receptor activity
H4O14_RS18770	COG1757	Na H antiporter
H4O14_RS18780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4O14_RS18785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4O14_RS18810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_RS18815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4O14_RS18820	COG0668	transmembrane transport
H4O14_RS18845	COG1764	response to oxidative stress
H4O14_RS18895	COG0628	permease
H4O14_RS18930	COG0402	S-adenosylhomocysteine deaminase activity
H4O14_RS18935	COG0583	DNA-binding transcription factor activity
H4O14_RS18945	COG2233	PERMEase
H4O14_RS18950	COG0640	Transcriptional regulator
H4O14_RS18955	COG1329	Transcriptional regulator
H4O14_RS18960	COG1295	ribonuclease BN
H4O14_RS18965	COG0671	phosphoesterase, PA-phosphatase related
H4O14_RS18970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4O14_RS18975	COG3829	transcription factor binding
H4O14_RS18985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_RS18990	COG1621	beta-fructofuranosidase activity
H4O14_RS19000	COG0395	ABC-type sugar transport system, permease component
H4O14_RS19005	COG4209	transmembrane transport
H4O14_RS19030	COG5646	InterPro IPR014922
H4O14_RS19040	COG4753	response regulator
H4O14_RS19040	COG2207	Transcriptional regulator
H4O14_RS19050	COG0745	RESPONSE REGULATOR receiver
H4O14_RS19055	COG5002	protein histidine kinase activity
H4O14_RS19060	COG4149	molybdate abc transporter
H4O14_RS19065	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4O14_RS19070	COG1999	signal sequence binding
H4O14_RS19085	COG2738	Putative neutral zinc metallopeptidase
H4O14_RS19090	COG3339	Conserved Protein
H4O14_RS19095	COG1742	UPF0060 membrane protein
H4O14_RS19100	COG2508	Transcriptional regulator
H4O14_RS19105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4O14_RS19110	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_RS19115	COG0506	proline dehydrogenase activity
H4O14_RS19135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H4O14_RS19140	COG0640	Transcriptional regulator
H4O14_RS19155	COG0492	ferredoxin-NADP+ reductase activity
H4O14_RS19175	COG2719	SpoVR family
H4O14_RS19195	COG2814	Major facilitator Superfamily
H4O14_RS19205	COG1959	2 iron, 2 sulfur cluster binding
H4O14_RS19220	COG1397	ADP-ribosylglycohydrolase
H4O14_RS19225	COG1609	Transcriptional regulator
H4O14_RS19240	COG0395	ABC-type sugar transport system, permease component
H4O14_RS19245	COG4209	transmembrane transport
H4O14_RS19250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_RS19275	COG0431	NADPH-dependent FMN reductase
H4O14_RS19280	COG2197	response regulator
H4O14_RS19285	COG2203	Gaf domain
H4O14_RS19285	COG4585	Histidine kinase
H4O14_RS19290	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_RS19295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4O14_RS19300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H4O14_RS19310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H4O14_RS19315	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H4O14_RS19320	COG3153	acetyltransferase
H4O14_RS19320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4O14_RS19325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4O14_RS19330	COG0517	IMP dehydrogenase activity
H4O14_RS19355	COG2801	Transposase and inactivated derivatives
H4O14_RS19365	COG0564	pseudouridine synthase activity
H4O14_RS19370	COG0456	acetyltransferase
H4O14_RS19375	COG3764	Sortase (surface protein transpeptidase)
H4O14_RS19380	COG0656	L-ascorbic acid biosynthetic process
H4O14_RS19385	COG2217	Heavy metal translocating P-type atpase
H4O14_RS19390	COG2259	Doxx family
H4O14_RS19395	COG1404	Belongs to the peptidase S8 family
H4O14_RS19400	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4O14_RS19405	COG0778	Nitroreductase
H4O14_RS19410	COG0306	phosphate transporter
H4O14_RS19415	COG1392	Phosphate transport regulator
H4O14_RS19420	COG1301	dicarboxylic acid transport
H4O14_RS19435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4O14_RS19440	COG3290	protein histidine kinase activity
H4O14_RS19450	COG2271	Major facilitator Superfamily
H4O14_RS19455	COG0659	secondary active sulfate transmembrane transporter activity
H4O14_RS19465	COG0395	ABC-type sugar transport system, permease component
H4O14_RS19470	COG1175	transmembrane transport
H4O14_RS19475	COG1653	transport
H4O14_RS19495	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
H4O14_RS19505	COG0640	Transcriptional regulator
H4O14_RS19515	COG0745	RESPONSE REGULATOR receiver
H4O14_RS19520	COG2205	protein histidine kinase activity
H4O14_RS19525	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H4O14_RS19525	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H4O14_RS19540	COG1486	melibiose metabolic process
H4O14_RS19545	COG1447	Phosphotransferase system cellobiose-specific component IIA
H4O14_RS19550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4O14_RS19555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4O14_RS19560	COG2323	membrane
H4O14_RS19575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4O14_RS19610	COG2766	serine protein kinase
H4O14_RS19615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4O14_RS19630	COG3382	B3 4 domain protein
H4O14_RS19640	COG2207	Transcriptional regulator
H4O14_RS19640	COG4753	response regulator
H4O14_RS19645	COG2972	Histidine kinase
H4O14_RS19665	COG4608	Belongs to the ABC transporter superfamily
H4O14_RS19680	COG1715	Restriction endonuclease
H4O14_RS19690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity