locus-tag	class	description
H7F25_RS00005	COG2113	Glycine betaine
H7F25_RS00010	COG0596	Alpha beta hydrolase
H7F25_RS00020	COG1473	amidohydrolase
H7F25_RS00025	COG1288	antiporter activity
H7F25_RS00030	COG0039	L-malate dehydrogenase activity
H7F25_RS00035	COG1620	l-lactate permease
H7F25_RS00040	COG1609	Transcriptional regulator
H7F25_RS00045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F25_RS00050	COG0561	phosphatase activity
H7F25_RS00055	COG0673	inositol 2-dehydrogenase activity
H7F25_RS00060	COG0738	Major facilitator superfamily
H7F25_RS00065	COG1280	lysine exporter protein (LysE YggA)
H7F25_RS00075	COG3403	YqcI/YcgG family
H7F25_RS00080	COG1113	amino acid transport
H7F25_RS00085	COG3665	Urea carboxylase-associated protein
H7F25_RS00090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7F25_RS00100	COG1012	belongs to the aldehyde dehydrogenase family
H7F25_RS00105	COG0710	3-dehydroquinate dehydratase activity
H7F25_RS00110	COG0028	Belongs to the TPP enzyme family
H7F25_RS00120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7F25_RS00125	COG2271	Major facilitator Superfamily
H7F25_RS00140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7F25_RS00145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7F25_RS00150	COG1609	Transcriptional regulator
H7F25_RS00155	COG0477	Major facilitator Superfamily
H7F25_RS00160	COG2226	methyltransferase
H7F25_RS00165	COG0583	DNA-binding transcription factor activity
H7F25_RS00170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7F25_RS00175	COG3458	cephalosporin-C deacetylase activity
H7F25_RS00185	COG3541	Predicted nucleotidyltransferase
H7F25_RS00190	COG0506	proline dehydrogenase activity
H7F25_RS00195	COG1012	belongs to the aldehyde dehydrogenase family
H7F25_RS00200	COG2508	Transcriptional regulator
H7F25_RS00205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H7F25_RS00210	COG0765	amino acid transport
H7F25_RS00215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F25_RS00225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7F25_RS00230	COG1522	sequence-specific DNA binding
H7F25_RS00235	COG2746	aminoglycoside 3-N-acetyltransferase activity
H7F25_RS00245	COG3290	protein histidine kinase activity
H7F25_RS00245	COG0840	transmembrane signaling receptor activity
H7F25_RS00250	COG3209	COG3209 Rhs family protein
H7F25_RS00270	COG3842	ATPase activity
H7F25_RS00285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F25_RS00290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F25_RS00295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F25_RS00310	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H7F25_RS00315	COG0697	spore germination
H7F25_RS00320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F25_RS00335	COG2364	Membrane
H7F25_RS00340	COG1126	abc transporter atp-binding protein
H7F25_RS00345	COG0765	amino acid transport
H7F25_RS00350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F25_RS00355	COG0833	amino acid
H7F25_RS00365	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS00370	COG1312	Catalyzes the dehydration of D-mannonate
H7F25_RS00375	COG1802	Transcriptional regulator
H7F25_RS00380	COG0673	inositol 2-dehydrogenase activity
H7F25_RS00390	COG1904	glucuronate isomerase
H7F25_RS00395	COG3104	oligopeptide transport
H7F25_RS00400	COG5434	Belongs to the glycosyl hydrolase 28 family
H7F25_RS00405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F25_RS00410	COG0456	acetyltransferase
H7F25_RS00415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F25_RS00420	COG0765	amino acid transport
H7F25_RS00425	COG1126	abc transporter atp-binding protein
H7F25_RS00430	COG1473	amidohydrolase
H7F25_RS00435	COG2079	MmgE PrpD family protein
H7F25_RS00440	COG0745	RESPONSE REGULATOR receiver
H7F25_RS00445	COG3850	Histidine kinase
H7F25_RS00445	COG5002	protein histidine kinase activity
H7F25_RS00450	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F25_RS00455	COG0527	aspartate kinase activity
H7F25_RS00460	COG2814	Major facilitator Superfamily
H7F25_RS00465	COG1309	transcriptional regulator
H7F25_RS00475	COG0640	Transcriptional regulator
H7F25_RS00480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F25_RS00485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7F25_RS00490	COG0531	amino acid
H7F25_RS00495	COG1012	belongs to the aldehyde dehydrogenase family
H7F25_RS00500	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7F25_RS00505	COG4549	nuclear export factor GLE1
H7F25_RS00510	COG2372	response to copper ion
H7F25_RS00510	COG1276	copper resistance
H7F25_RS00515	COG2213	PTS system mannitol-specific
H7F25_RS00520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS00525	COG0246	Mannitol dehydrogenase
H7F25_RS00530	COG0840	transmembrane signaling receptor activity
H7F25_RS00555	COG0346	lactoylglutathione lyase activity
H7F25_RS00565	COG0561	phosphatase activity
H7F25_RS00570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H7F25_RS00575	COG1914	H( )-stimulated, divalent metal cation uptake system
H7F25_RS00580	COG4336	lyase activity
H7F25_RS00585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H7F25_RS00590	COG1984	allophanate hydrolase subunit 2
H7F25_RS00595	COG1414	Transcriptional regulator
H7F25_RS00600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7F25_RS00605	COG2755	lipolytic protein G-D-S-L family
H7F25_RS00615	COG3711	transcriptional antiterminator
H7F25_RS00620	COG2226	methyltransferase
H7F25_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS00630	COG3871	stress protein (general stress protein 26)
H7F25_RS00655	COG2814	Major facilitator Superfamily
H7F25_RS00660	COG1802	Transcriptional regulator
H7F25_RS00665	COG1917	Cupin 2, conserved barrel domain protein
H7F25_RS00665	COG2207	Transcriptional regulator
H7F25_RS00670	COG0697	spore germination
H7F25_RS00675	COG0473	3-isopropylmalate dehydrogenase activity
H7F25_RS00680	COG0551	DNA topoisomerase type I activity
H7F25_RS00680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7F25_RS00685	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7F25_RS00690	COG3706	GGDEF domain
H7F25_RS00695	COG5298	Protein conserved in bacteria
H7F25_RS00700	COG1215	transferase activity, transferring glycosyl groups
H7F25_RS00710	COG0531	amino acid
H7F25_RS00715	COG0028	Belongs to the TPP enzyme family
H7F25_RS00720	COG5444	nuclease activity
H7F25_RS00745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F25_RS00750	COG1914	H( )-stimulated, divalent metal cation uptake system
H7F25_RS00755	COG2261	transglycosylase associated protein
H7F25_RS00760	COG2217	Heavy metal translocating P-type atpase
H7F25_RS00765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H7F25_RS00770	COG3290	protein histidine kinase activity
H7F25_RS00775	COG4565	transcriptional regulatory protein
H7F25_RS00780	COG1301	dicarboxylic acid transport
H7F25_RS00785	COG0628	permease
H7F25_RS00790	COG1301	dicarboxylic acid transport
H7F25_RS00795	COG1131	(ABC) transporter
H7F25_RS00800	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H7F25_RS00815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F25_RS00820	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7F25_RS00825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7F25_RS00840	COG0513	Belongs to the DEAD box helicase family
H7F25_RS00845	COG3402	PFAM membrane-flanked domain
H7F25_RS00850	COG3428	Bacterial PH domain
H7F25_RS00855	COG0705	Rhomboid family
H7F25_RS00860	COG0736	holo-[acyl-carrier-protein] synthase activity
H7F25_RS00865	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7F25_RS00870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7F25_RS00875	COG0864	Transcriptional regulator
H7F25_RS00880	COG2337	Toxic component of a toxin-antitoxin (TA) module
H7F25_RS00885	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F25_RS00890	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F25_RS00895	COG2172	sigma factor antagonist activity
H7F25_RS00900	COG2208	phosphoserine phosphatase activity
H7F25_RS00905	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F25_RS00910	COG2172	sigma factor antagonist activity
H7F25_RS00915	COG1191	sigma factor activity
H7F25_RS00920	COG2208	phosphoserine phosphatase activity
H7F25_RS00925	COG2183	response to ionizing radiation
H7F25_RS00935	COG3091	SprT-like family
H7F25_RS00940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F25_RS00945	COG0022	dehydrogenase e1 component
H7F25_RS00950	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F25_RS00955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F25_RS00960	COG3284	Transcriptional regulator
H7F25_RS01000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7F25_RS01010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F25_RS01015	COG0456	acetyltransferase
H7F25_RS01015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H7F25_RS01020	COG1278	Cold shock
H7F25_RS01025	COG1404	Belongs to the peptidase S8 family
H7F25_RS01040	COG0789	Transcriptional regulator
H7F25_RS01050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7F25_RS01075	COG0477	Major facilitator Superfamily
H7F25_RS01080	COG0657	acetylesterase activity
H7F25_RS01085	COG4221	oxidoreductase activity
H7F25_RS01095	COG0252	asparaginase activity
H7F25_RS01115	COG2814	Major facilitator Superfamily
H7F25_RS01120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F25_RS01150	COG1309	transcriptional regulator
H7F25_RS01155	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7F25_RS01160	COG1846	Transcriptional regulator
H7F25_RS01165	COG0778	Nitroreductase
H7F25_RS01180	COG1396	sequence-specific DNA binding
H7F25_RS01200	COG4122	O-methyltransferase activity
H7F25_RS01210	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H7F25_RS01215	COG0697	spore germination
H7F25_RS01225	COG1301	dicarboxylic acid transport
H7F25_RS01265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7F25_RS01270	COG0802	atpase or kinase
H7F25_RS01275	COG1214	PFAM Peptidase M22, glycoprotease
H7F25_RS01280	COG0456	acetyltransferase
H7F25_RS01285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7F25_RS01290	COG0488	(ABC) transporter
H7F25_RS01295	COG0315	cyclic pyranopterin monophosphate synthase activity
H7F25_RS01300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H7F25_RS01305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7F25_RS01310	COG0805	protein transport
H7F25_RS01325	COG1266	CAAX protease self-immunity
H7F25_RS01330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7F25_RS01335	COG0459	protein refolding
H7F25_RS01410	COG1846	Transcriptional regulator
H7F25_RS01415	COG0456	acetyltransferase
H7F25_RS01420	COG2808	Putative FMN-binding domain
H7F25_RS01450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7F25_RS01455	COG0823	Involved in the tonB-independent uptake of proteins
H7F25_RS01465	COG2132	Multicopper oxidase
H7F25_RS01470	COG1113	amino acid transport
H7F25_RS01475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7F25_RS01480	COG0714	Associated with various cellular activities
H7F25_RS01485	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
H7F25_RS01490	COG1305	Transglutaminase-like
H7F25_RS01495	COG0519	Catalyzes the synthesis of GMP from XMP
H7F25_RS01495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7F25_RS01500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7F25_RS01510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7F25_RS01515	COG2207	Transcriptional regulator
H7F25_RS01530	COG1404	Belongs to the peptidase S8 family
H7F25_RS01545	COG2814	Major facilitator Superfamily
H7F25_RS01550	COG0583	DNA-binding transcription factor activity
H7F25_RS01555	COG2252	PERMEase
H7F25_RS01570	COG3064	Membrane
H7F25_RS01575	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H7F25_RS01585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7F25_RS01590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7F25_RS01595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7F25_RS01600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7F25_RS01605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7F25_RS01610	COG0047	phosphoribosylformylglycinamidine synthase activity
H7F25_RS01615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7F25_RS01620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7F25_RS01625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7F25_RS01630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7F25_RS01635	COG0138	bifunctional purine biosynthesis protein purh
H7F25_RS01640	COG0151	Belongs to the GarS family
H7F25_RS01660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7F25_RS01665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7F25_RS01670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H7F25_RS01675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7F25_RS01685	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7F25_RS01690	COG4496	protein, YerC YecD
H7F25_RS01695	COG0069	glutamate synthase activity
H7F25_RS01710	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H7F25_RS01715	COG0210	DNA helicase
H7F25_RS01720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7F25_RS01725	COG4851	CamS sex pheromone cAM373 precursor
H7F25_RS01740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7F25_RS01755	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F25_RS01770	COG1960	acyl-CoA dehydrogenase activity
H7F25_RS01800	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7F25_RS01805	COG1785	Belongs to the alkaline phosphatase family
H7F25_RS01810	COG1285	pathogenesis
H7F25_RS01815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F25_RS01820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7F25_RS01825	COG0154	amidase activity
H7F25_RS01830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H7F25_RS01835	COG1309	transcriptional regulator
H7F25_RS01840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7F25_RS01845	COG1957	nucleoside hydrolase
H7F25_RS01850	COG1597	lipid kinase activity
H7F25_RS01855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7F25_RS01860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7F25_RS01870	COG1737	Transcriptional regulator
H7F25_RS01875	COG1263	PTS System
H7F25_RS01875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS01880	COG1486	melibiose metabolic process
H7F25_RS01890	COG1959	2 iron, 2 sulfur cluster binding
H7F25_RS01895	COG0492	ferredoxin-NADP+ reductase activity
H7F25_RS01910	COG1486	melibiose metabolic process
H7F25_RS01920	COG2211	Major facilitator Superfamily
H7F25_RS01950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7F25_RS01955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F25_RS01960	COG1442	glycosyl transferase family 8
H7F25_RS01965	COG1216	Glycosyl transferase, family 2
H7F25_RS01970	COG1442	glycosyl transferase family 8
H7F25_RS01975	COG2223	nitrite transmembrane transporter activity
H7F25_RS01985	COG0471	metal ion transport
H7F25_RS02000	COG0071	Belongs to the small heat shock protein (HSP20) family
H7F25_RS02015	COG0531	amino acid
H7F25_RS02020	COG0463	Glycosyl transferase, family 2
H7F25_RS02025	COG0488	(ABC) transporter
H7F25_RS02030	COG1469	GTP cyclohydrolase I activity
H7F25_RS02035	COG0789	Transcriptional regulator
H7F25_RS02040	COG2814	Major facilitator Superfamily
H7F25_RS02045	COG0488	(ABC) transporter
H7F25_RS02050	COG0513	Belongs to the DEAD box helicase family
H7F25_RS02065	COG2130	NADP-dependent
H7F25_RS02085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F25_RS02085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F25_RS02090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7F25_RS02100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F25_RS02100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F25_RS02110	COG3290	protein histidine kinase activity
H7F25_RS02115	COG4565	transcriptional regulatory protein
H7F25_RS02120	COG3181	Tripartite tricarboxylate transporter family receptor
H7F25_RS02125	COG2851	Citrate transporter
H7F25_RS02135	COG3479	Phenolic acid decarboxylase
H7F25_RS02140	COG1695	Transcriptional regulator
H7F25_RS02145	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H7F25_RS02150	COG1254	Belongs to the acylphosphatase family
H7F25_RS02155	COG2258	MOSC domain
H7F25_RS02170	COG0024	Methionine aminopeptidase
H7F25_RS02175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS02175	COG1263	PTS System
H7F25_RS02180	COG3739	integral membrane protein
H7F25_RS02195	COG1368	sulfuric ester hydrolase activity
H7F25_RS02200	COG0076	glutamate decarboxylase activity
H7F25_RS02205	COG0840	transmembrane signaling receptor activity
H7F25_RS02215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS02215	COG1263	PTS System
H7F25_RS02220	COG0366	Alpha amylase catalytic
H7F25_RS02225	COG2188	Transcriptional regulator
H7F25_RS02235	COG0737	Belongs to the 5'-nucleotidase family
H7F25_RS02240	COG0693	protein deglycase activity
H7F25_RS02245	COG4840	Belongs to the UPF0435 family
H7F25_RS02250	COG1115	amino acid carrier protein
H7F25_RS02255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7F25_RS02260	COG4980	gas vesicle protein
H7F25_RS02265	COG1295	ribonuclease BN
H7F25_RS02270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F25_RS02285	COG0387	Pfam Sodium calcium exchanger
H7F25_RS02295	COG0217	transcriptional regulatory protein
H7F25_RS02300	COG0668	transmembrane transport
H7F25_RS02305	COG0535	radical SAM domain protein
H7F25_RS02315	COG0726	polysaccharide deacetylase
H7F25_RS02320	COG0598	Magnesium transport protein CorA
H7F25_RS02330	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H7F25_RS02335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7F25_RS02350	COG0789	Transcriptional regulator
H7F25_RS02355	COG2814	Major facilitator Superfamily
H7F25_RS02365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7F25_RS02410	COG2076	Multidrug Resistance protein
H7F25_RS02415	COG2076	Multidrug Resistance protein
H7F25_RS02420	COG1309	transcriptional regulator
H7F25_RS02430	COG4637	Psort location Cytoplasmic, score
H7F25_RS02435	COG2755	lipolytic protein G-D-S-L family
H7F25_RS02440	COG0492	ferredoxin-NADP+ reductase activity
H7F25_RS02445	COG1742	UPF0060 membrane protein
H7F25_RS02460	COG2318	DinB family
H7F25_RS02470	COG1846	Transcriptional regulator
H7F25_RS02475	COG0392	lysyltransferase activity
H7F25_RS02475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7F25_RS02495	COG0778	Nitroreductase
H7F25_RS02510	COG1090	epimerase
H7F25_RS02515	COG2137	regulation of response to DNA damage stimulus
H7F25_RS02540	COG0463	Glycosyl transferase, family 2
H7F25_RS02545	COG4485	Bacterial membrane protein, YfhO
H7F25_RS02555	COG2140	Oxalate decarboxylase
H7F25_RS02565	COG1191	sigma factor activity
H7F25_RS02575	COG1988	membrane-bound metal-dependent
H7F25_RS02580	COG1194	a g-specific adenine glycosylase
H7F25_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS02605	COG3557	Belongs to the UPF0374 family
H7F25_RS02610	COG1132	(ABC) transporter
H7F25_RS02615	COG0444	Belongs to the ABC transporter superfamily
H7F25_RS02620	COG4608	Belongs to the ABC transporter superfamily
H7F25_RS02625	COG0747	negative chemotaxis
H7F25_RS02630	COG0601	transmembrane transport
H7F25_RS02635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F25_RS02640	COG4129	membrane
H7F25_RS02645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7F25_RS02650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7F25_RS02655	COG0735	belongs to the Fur family
H7F25_RS02805	COG1368	sulfuric ester hydrolase activity
H7F25_RS02810	COG0681	Belongs to the peptidase S26 family
H7F25_RS02815	COG2873	o-acetylhomoserine
H7F25_RS02825	COG1116	anion transmembrane transporter activity
H7F25_RS02830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7F25_RS02835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7F25_RS02850	COG4152	abc transporter atp-binding protein
H7F25_RS02880	COG3382	B3 4 domain protein
H7F25_RS02885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7F25_RS02895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7F25_RS02900	COG2766	serine protein kinase
H7F25_RS02905	COG2718	Belongs to the UPF0229 family
H7F25_RS02910	COG1566	PFAM secretion protein HlyD family protein
H7F25_RS02915	COG2814	Major facilitator Superfamily
H7F25_RS02920	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7F25_RS02930	COG1278	Cold shock
H7F25_RS02935	COG3706	GGDEF domain
H7F25_RS02960	COG5577	PFAM Coat F domain
H7F25_RS02965	COG5002	protein histidine kinase activity
H7F25_RS02970	COG0737	Belongs to the 5'-nucleotidase family
H7F25_RS02970	COG1525	nuclease
H7F25_RS02970	COG4085	toxin activity
H7F25_RS02975	COG3764	Sortase (surface protein transpeptidase)
H7F25_RS02980	COG0564	pseudouridine synthase activity
H7F25_RS02990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7F25_RS02995	COG3153	acetyltransferase
H7F25_RS02995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7F25_RS03010	COG3835	regulator
H7F25_RS03015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7F25_RS03020	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H7F25_RS03025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7F25_RS03030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7F25_RS03035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7F25_RS03040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7F25_RS03045	COG4585	Histidine kinase
H7F25_RS03045	COG2203	Gaf domain
H7F25_RS03050	COG2197	response regulator
H7F25_RS03065	COG0753	catalase activity
H7F25_RS03070	COG1959	2 iron, 2 sulfur cluster binding
H7F25_RS03075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7F25_RS03075	COG1017	nitric oxide dioxygenase activity
H7F25_RS03080	COG2719	SpoVR family
H7F25_RS03085	COG1785	Belongs to the alkaline phosphatase family
H7F25_RS03090	COG1388	LysM domain
H7F25_RS03090	COG0791	NLP P60 protein
H7F25_RS03095	COG0531	amino acid
H7F25_RS03110	COG1595	DNA-templated transcription, initiation
H7F25_RS03115	COG0204	Acyl-transferase
H7F25_RS03120	COG1253	flavin adenine dinucleotide binding
H7F25_RS03125	COG0789	Transcriptional regulator
H7F25_RS03130	COG1253	flavin adenine dinucleotide binding
H7F25_RS03140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7F25_RS03145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7F25_RS03150	COG0584	glycerophosphoryl diester phosphodiesterase
H7F25_RS03160	COG0668	transmembrane transport
H7F25_RS03165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7F25_RS03170	COG0726	polysaccharide deacetylase
H7F25_RS03175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F25_RS03180	COG0589	response to stress
H7F25_RS03185	COG1132	(ABC) transporter
H7F25_RS03190	COG1132	(ABC) transporter
H7F25_RS03200	COG0702	epimerase
H7F25_RS03210	COG3842	ATPase activity
H7F25_RS03215	COG2508	Transcriptional regulator
H7F25_RS03225	COG0189	ligase activity
H7F25_RS03230	COG0189	ligase activity
H7F25_RS03235	COG4399	Belongs to the UPF0754 family
H7F25_RS03240	COG3679	Belongs to the UPF0342 family
H7F25_RS03245	COG0561	phosphatase activity
H7F25_RS03250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7F25_RS03260	COG0475	glutathione-regulated potassium exporter activity
H7F25_RS03265	COG0490	domain, Protein
H7F25_RS03275	COG1024	Enoyl-CoA hydratase
H7F25_RS03285	COG0420	3'-5' exonuclease activity
H7F25_RS03290	COG4717	serine-type aminopeptidase activity
H7F25_RS03295	COG3481	metal-dependent phosphohydrolase, HD sub domain
H7F25_RS03305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7F25_RS03330	COG1846	Transcriptional regulator
H7F25_RS03335	COG4980	gas vesicle protein
H7F25_RS03350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7F25_RS03355	COG0537	adenosine 5'-monophosphoramidase activity
H7F25_RS03360	COG1131	(ABC) transporter
H7F25_RS03365	COG4473	ABC transporter
H7F25_RS03375	COG1473	amidohydrolase
H7F25_RS03385	COG2329	Antibiotic biosynthesis monooxygenase
H7F25_RS03390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F25_RS03395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7F25_RS03400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7F25_RS03405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7F25_RS03410	COG1309	transcriptional regulator
H7F25_RS03415	COG1511	domain protein
H7F25_RS03420	COG1363	Peptidase, m42
H7F25_RS03425	COG1301	dicarboxylic acid transport
H7F25_RS03435	COG1234	tRNA 3'-trailer cleavage
H7F25_RS03440	COG0095	Lipoate-protein ligase
H7F25_RS03445	COG0318	PFAM AMP-dependent synthetase and ligase
H7F25_RS03455	COG0501	Belongs to the peptidase M48B family
H7F25_RS03460	COG1404	Belongs to the peptidase S8 family
H7F25_RS03465	COG0406	alpha-ribazole phosphatase activity
H7F25_RS03470	COG0840	transmembrane signaling receptor activity
H7F25_RS03475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7F25_RS03475	COG0723	plastoquinol--plastocyanin reductase activity
H7F25_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS03490	COG4903	ComK protein
H7F25_RS03500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F25_RS03505	COG2814	Major facilitator Superfamily
H7F25_RS03510	COG2732	(Barnase) inhibitor
H7F25_RS03515	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F25_RS03520	COG4605	iron ion homeostasis
H7F25_RS03525	COG4604	ABC transporter, ATP-binding protein
H7F25_RS03530	COG4607	ABC-type enterochelin transport system periplasmic component
H7F25_RS03535	COG1316	TRANSCRIPTIONal
H7F25_RS03545	COG0398	Pfam SNARE associated Golgi protein
H7F25_RS03550	COG0681	Belongs to the peptidase S26 family
H7F25_RS03555	COG3180	Ammonia monooxygenase
H7F25_RS03565	COG0501	Belongs to the peptidase M48B family
H7F25_RS03570	COG2259	Doxx family
H7F25_RS03575	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H7F25_RS03580	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H7F25_RS03585	COG1074	ATP-dependent DNA helicase activity
H7F25_RS03590	COG0420	3'-5' exonuclease activity
H7F25_RS03595	COG0419	ATPase involved in DNA repair
H7F25_RS03600	COG1403	HNH endonuclease
H7F25_RS03640	COG5337	Spore coat protein CotH
H7F25_RS03650	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7F25_RS03665	COG0367	asparagine synthase
H7F25_RS03680	COG1562	ergosterol biosynthetic process
H7F25_RS03685	COG0534	Mate efflux family protein
H7F25_RS03690	COG1917	Cupin 2, conserved barrel domain protein
H7F25_RS03690	COG2207	Transcriptional regulator
H7F25_RS03720	COG0076	glutamate decarboxylase activity
H7F25_RS03750	COG1410	methionine synthase
H7F25_RS03750	COG0646	methionine synthase
H7F25_RS03755	COG0646	methionine synthase
H7F25_RS03755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7F25_RS03760	COG1666	GTP binding
H7F25_RS03765	COG2996	Protein conserved in bacteria
H7F25_RS03770	COG1744	ABC transporter substrate-binding protein PnrA-like
H7F25_RS03775	COG0840	transmembrane signaling receptor activity
H7F25_RS03780	COG1307	EDD domain protein, DegV family
H7F25_RS03785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F25_RS03805	COG0561	phosphatase activity
H7F25_RS03810	COG1073	alpha beta
H7F25_RS03815	COG2151	metal-sulfur cluster biosynthetic enzyme
H7F25_RS03820	COG0277	FAD linked oxidase domain protein
H7F25_RS03825	COG2271	Major facilitator Superfamily
H7F25_RS03830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7F25_RS03835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H7F25_RS03840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7F25_RS03845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7F25_RS03850	COG0505	Belongs to the CarA family
H7F25_RS03855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7F25_RS03860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7F25_RS03870	COG2814	Major facilitator Superfamily
H7F25_RS03880	COG2267	carboxylic ester hydrolase activity
H7F25_RS03890	COG1744	ABC transporter substrate-binding protein PnrA-like
H7F25_RS03905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F25_RS03910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F25_RS03915	COG5504	Zn-dependent protease
H7F25_RS03920	COG0444	Belongs to the ABC transporter superfamily
H7F25_RS03925	COG4608	Belongs to the ABC transporter superfamily
H7F25_RS03935	COG0601	transmembrane transport
H7F25_RS03940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F25_RS03960	COG0180	Tryptophanyl-tRNA synthetase
H7F25_RS03970	COG4166	transmembrane transport
H7F25_RS03975	COG0601	transmembrane transport
H7F25_RS03980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F25_RS03985	COG0444	Belongs to the ABC transporter superfamily
H7F25_RS03990	COG4608	Belongs to the ABC transporter superfamily
H7F25_RS04000	COG0456	acetyltransferase
H7F25_RS04005	COG1393	Belongs to the ArsC family
H7F25_RS04010	COG0861	Integral membrane protein TerC family
H7F25_RS04015	COG4862	establishment of competence for transformation
H7F25_RS04020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F25_RS04030	COG1164	Oligoendopeptidase f
H7F25_RS04040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7F25_RS04045	COG2346	COG2346, Truncated hemoglobins
H7F25_RS04050	COG0741	lytic transglycosylase activity
H7F25_RS04055	COG4116	CYTH
H7F25_RS04065	COG2357	RelA SpoT domain protein
H7F25_RS04070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7F25_RS04075	COG0564	pseudouridine synthase activity
H7F25_RS04080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7F25_RS04085	COG0475	glutathione-regulated potassium exporter activity
H7F25_RS04085	COG0569	domain protein
H7F25_RS04090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7F25_RS04095	COG0352	thiamine-phosphate diphosphorylase activity
H7F25_RS04105	COG2104	thiamine diphosphate biosynthetic process
H7F25_RS04110	COG2022	thiamine diphosphate biosynthetic process
H7F25_RS04115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7F25_RS04120	COG0351	phosphomethylpyrimidine kinase
H7F25_RS04125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7F25_RS04180	COG0210	DNA helicase
H7F25_RS04195	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H7F25_RS04200	COG2382	esterase
H7F25_RS04205	COG0626	cystathionine gamma-synthase activity
H7F25_RS04210	COG0626	cystathionine gamma-synthase activity
H7F25_RS04360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7F25_RS04390	COG1780	Probably involved in ribonucleotide reductase function
H7F25_RS04395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F25_RS04405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F25_RS04425	COG0756	dUTP diphosphatase activity
H7F25_RS04435	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H7F25_RS04520	COG0582	viral genome integration into host DNA
H7F25_RS04595	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7F25_RS04630	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS04630	COG3409	Peptidoglycan-binding domain 1 protein
H7F25_RS04665	COG0457	Tetratricopeptide repeat
H7F25_RS04670	COG1733	regulation of RNA biosynthetic process
H7F25_RS04680	COG0604	alcohol dehydrogenase
H7F25_RS04690	COG0825	malonyl-CoA metabolic process
H7F25_RS04700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F25_RS04750	COG0457	Tetratricopeptide repeat
H7F25_RS04780	COG0583	DNA-binding transcription factor activity
H7F25_RS04785	COG2807	transmembrane transport
H7F25_RS04805	COG0457	Tetratricopeptide repeat
H7F25_RS04835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7F25_RS04855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F25_RS04860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F25_RS04865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F25_RS04885	COG4195	phage-related replication protein
H7F25_RS04890	COG2856	Zn peptidase
H7F25_RS04895	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS04895	COG3409	Peptidoglycan-binding domain 1 protein
H7F25_RS04915	COG0306	phosphate transporter
H7F25_RS04920	COG1392	Phosphate transport regulator
H7F25_RS04930	COG0405	Gamma-glutamyltransferase
H7F25_RS04935	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7F25_RS04945	COG4208	sulfate ABC transporter
H7F25_RS04950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7F25_RS04960	COG3775	system Galactitol-specific IIC component
H7F25_RS04975	COG1063	alcohol dehydrogenase
H7F25_RS04980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F25_RS04985	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F25_RS04985	COG0022	dehydrogenase e1 component
H7F25_RS04990	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F25_RS04995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F25_RS05000	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS05010	COG2390	Transcriptional regulator
H7F25_RS05020	COG0531	amino acid
H7F25_RS05025	COG0346	lactoylglutathione lyase activity
H7F25_RS05030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F25_RS05035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F25_RS05040	COG2362	D-Aminopeptidase
H7F25_RS05045	COG0601	transmembrane transport
H7F25_RS05050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F25_RS05055	COG0444	Belongs to the ABC transporter superfamily
H7F25_RS05060	COG4166	transmembrane transport
H7F25_RS05065	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7F25_RS05070	COG4948	Mandelate Racemase Muconate Lactonizing
H7F25_RS05075	COG0791	NLP P60 protein
H7F25_RS05080	COG4608	Belongs to the ABC transporter superfamily
H7F25_RS05085	COG1834	amidinotransferase
H7F25_RS05090	COG1607	acyl-coa hydrolase
H7F25_RS05095	COG1695	Transcriptional regulator
H7F25_RS05110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F25_RS05125	COG2076	Multidrug Resistance protein
H7F25_RS05130	COG2076	Multidrug Resistance protein
H7F25_RS05140	COG0788	formyltetrahydrofolate deformylase activity
H7F25_RS05145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7F25_RS05150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7F25_RS05155	COG0457	Tetratricopeptide repeat
H7F25_RS05165	COG1764	response to oxidative stress
H7F25_RS05170	COG1846	Transcriptional regulator
H7F25_RS05175	COG1764	response to oxidative stress
H7F25_RS05180	COG0590	tRNA wobble adenosine to inosine editing
H7F25_RS05185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7F25_RS05190	COG1404	Belongs to the peptidase S8 family
H7F25_RS05195	COG0745	RESPONSE REGULATOR receiver
H7F25_RS05200	COG3850	Histidine kinase
H7F25_RS05200	COG5002	protein histidine kinase activity
H7F25_RS05205	COG3212	peptidase
H7F25_RS05210	COG3212	peptidase
H7F25_RS05220	COG2239	Acts as a magnesium transporter
H7F25_RS05230	COG0789	Transcriptional regulator
H7F25_RS05250	COG1846	Transcriptional regulator
H7F25_RS05255	COG5001	Diguanylate cyclase
H7F25_RS05255	COG3300	MHYT domain
H7F25_RS05260	COG0586	Pfam SNARE associated Golgi protein
H7F25_RS05265	COG0861	Integral membrane protein TerC family
H7F25_RS05270	COG1191	sigma factor activity
H7F25_RS05290	COG0501	Belongs to the peptidase M48B family
H7F25_RS05295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7F25_RS05300	COG2323	membrane
H7F25_RS05315	COG3594	Acyltransferase
H7F25_RS05320	COG5002	protein histidine kinase activity
H7F25_RS05325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7F25_RS05335	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H7F25_RS05340	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H7F25_RS05345	COG0436	Aminotransferase
H7F25_RS05350	COG1850	ribulose-bisphosphate carboxylase activity
H7F25_RS05360	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H7F25_RS05370	COG3852	Histidine kinase
H7F25_RS05375	COG1846	Transcriptional regulator
H7F25_RS05380	COG1360	Flagellar Motor Protein
H7F25_RS05385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7F25_RS05390	COG0542	response to heat
H7F25_RS05395	COG3949	Membrane
H7F25_RS05400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7F25_RS05405	COG0720	synthase
H7F25_RS05410	COG0602	queuosine metabolic process
H7F25_RS05415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7F25_RS05420	COG1733	regulation of RNA biosynthetic process
H7F25_RS05425	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS05435	COG4873	Protein conserved in bacteria
H7F25_RS05445	COG3773	Cell wall hydrolase
H7F25_RS05450	COG2244	polysaccharide biosynthetic process
H7F25_RS05455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F25_RS05460	COG2217	Heavy metal translocating P-type atpase
H7F25_RS05465	COG0006	proline dipeptidase activity
H7F25_RS05475	COG1609	Transcriptional regulator
H7F25_RS05480	COG3711	transcriptional antiterminator
H7F25_RS05485	COG2190	(PTS) system
H7F25_RS05485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS05485	COG1263	PTS System
H7F25_RS05490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS05495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7F25_RS05505	COG1533	DNA photolyase activity
H7F25_RS05510	COG0840	transmembrane signaling receptor activity
H7F25_RS05520	COG2084	Dehydrogenase
H7F25_RS05525	COG2340	Cysteine-rich secretory protein family
H7F25_RS05530	COG0768	penicillin binding
H7F25_RS05535	COG4191	Histidine kinase
H7F25_RS05540	COG0436	Aminotransferase
H7F25_RS05545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7F25_RS05555	COG1714	RDD family
H7F25_RS05565	COG0784	Response regulator, receiver
H7F25_RS05565	COG0835	chemotaxis
H7F25_RS05575	COG1917	Cupin 2, conserved barrel domain protein
H7F25_RS05575	COG2207	Transcriptional regulator
H7F25_RS05580	COG0697	spore germination
H7F25_RS05590	COG2814	Major facilitator Superfamily
H7F25_RS05595	COG1376	ErfK ybiS ycfS ynhG family protein
H7F25_RS05600	COG1408	metallophosphoesterase
H7F25_RS05605	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS05610	COG2200	EAL domain
H7F25_RS05615	COG3546	catalase activity
H7F25_RS05620	COG4703	Protein of unknown function (DUF1797)
H7F25_RS05625	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H7F25_RS05635	COG0517	IMP dehydrogenase activity
H7F25_RS05640	COG0583	DNA-binding transcription factor activity
H7F25_RS05645	COG0716	FMN binding
H7F25_RS05655	COG0716	FMN binding
H7F25_RS05660	COG2171	N-acyltransferase activity
H7F25_RS05665	COG1473	amidohydrolase
H7F25_RS05675	COG0668	transmembrane transport
H7F25_RS05680	COG0450	alkyl hydroperoxide reductase
H7F25_RS05685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F25_RS05700	COG0746	molybdenum cofactor guanylyltransferase activity
H7F25_RS05705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7F25_RS05710	COG0303	'Molybdopterin
H7F25_RS05715	COG1763	Mo-molybdopterin cofactor biosynthetic process
H7F25_RS05720	COG0314	molybdopterin synthase activity
H7F25_RS05725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7F25_RS05740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7F25_RS05745	COG1136	(ABC) transporter
H7F25_RS05750	COG0577	efflux transmembrane transporter activity
H7F25_RS05755	COG1349	DNA-binding transcription factor activity
H7F25_RS05760	COG1105	Belongs to the carbohydrate kinase PfkB family
H7F25_RS05765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F25_RS05765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F25_RS05765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS05770	COG0681	Belongs to the peptidase S26 family
H7F25_RS05780	COG0488	(ABC) transporter
H7F25_RS05785	COG2309	aminopeptidase activity
H7F25_RS05795	COG1077	Cell shape determining protein MreB Mrl
H7F25_RS05800	COG2002	toxin-antitoxin pair type II binding
H7F25_RS05805	COG3852	Histidine kinase
H7F25_RS05810	COG2105	PFAM AIG2 family protein
H7F25_RS05810	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H7F25_RS05815	COG0569	domain protein
H7F25_RS05820	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7F25_RS05825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H7F25_RS05830	COG5503	Protein of unknown function (DUF1447)
H7F25_RS05835	COG0561	phosphatase activity
H7F25_RS05840	COG0242	peptide deformylase activity
H7F25_RS05855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F25_RS05860	COG0022	dehydrogenase e1 component
H7F25_RS05865	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F25_RS05870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F25_RS05875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F25_RS05885	COG1982	Orn Lys Arg decarboxylase major
H7F25_RS05890	COG4476	Belongs to the UPF0223 family
H7F25_RS05895	COG4493	Belongs to the UPF0637 family
H7F25_RS05905	COG0483	inositol monophosphate 1-phosphatase activity
H7F25_RS05920	COG1595	DNA-templated transcription, initiation
H7F25_RS05940	COG1217	gtp-binding protein TYPA
H7F25_RS05950	COG4896	Protein conserved in bacteria
H7F25_RS05960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7F25_RS05965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7F25_RS05970	COG2066	Belongs to the glutaminase family
H7F25_RS05975	COG4838	Belongs to the UPF0358 family
H7F25_RS05980	COG0772	Belongs to the SEDS family
H7F25_RS05985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H7F25_RS05990	COG0415	Belongs to the DNA photolyase family
H7F25_RS05995	COG1612	heme a metabolic process
H7F25_RS06000	COG0109	protoheme IX farnesyltransferase activity
H7F25_RS06005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7F25_RS06005	COG2010	Cytochrome c
H7F25_RS06010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7F25_RS06015	COG1845	cytochrome c oxidase, subunit III
H7F25_RS06020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7F25_RS06025	COG3336	cytochrome c oxidase
H7F25_RS06035	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H7F25_RS06040	COG2340	Cysteine-rich secretory protein family
H7F25_RS06060	COG3679	Belongs to the UPF0342 family
H7F25_RS06065	COG4471	UPF0298 protein
H7F25_RS06070	COG0742	ribosomal rna small subunit methyltransferase
H7F25_RS06075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7F25_RS06080	COG3314	Sporulation integral membrane protein YlbJ
H7F25_RS06085	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7F25_RS06090	COG3480	Lon protease (S16) C-terminal proteolytic domain
H7F25_RS06100	COG1399	metal-binding, possibly nucleic acid-binding protein
H7F25_RS06105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7F25_RS06115	COG0454	-acetyltransferase
H7F25_RS06120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7F25_RS06125	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H7F25_RS06130	COG2001	Belongs to the MraZ family
H7F25_RS06135	COG0275	rRNA processing
H7F25_RS06140	COG4839	cell division protein FtsL
H7F25_RS06145	COG0768	penicillin binding
H7F25_RS06150	COG0768	penicillin binding
H7F25_RS06155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7F25_RS06160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7F25_RS06165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7F25_RS06170	COG0772	Belongs to the SEDS family
H7F25_RS06175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7F25_RS06180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7F25_RS06185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7F25_RS06190	COG3879	Bacterial protein of unknown function (DUF881)
H7F25_RS06195	COG3879	Bacterial protein of unknown function (DUF881)
H7F25_RS06200	COG3856	small basic protein
H7F25_RS06205	COG0849	cell division
H7F25_RS06210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7F25_RS06215	COG1404	Belongs to the peptidase S8 family
H7F25_RS06215	COG4412	M6 family metalloprotease domain protein
H7F25_RS06225	COG1191	sigma factor activity
H7F25_RS06230	COG1191	sigma factor activity
H7F25_RS06235	COG2390	Transcriptional regulator
H7F25_RS06250	COG3730	PTS system glucitol sorbitol-specific
H7F25_RS06255	COG3732	PTS system glucitol sorbitol-specific
H7F25_RS06265	COG1119	ATPase activity
H7F25_RS06270	COG1873	PFAM PRC-barrel domain
H7F25_RS06275	COG1496	oxidoreductase activity
H7F25_RS06280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7F25_RS06285	COG1799	cell septum assembly
H7F25_RS06290	COG0762	integral membrane protein
H7F25_RS06295	COG2302	S4 RNA-binding domain
H7F25_RS06300	COG3599	regulation of cell shape
H7F25_RS06305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7F25_RS06310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7F25_RS06315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7F25_RS06320	COG0564	pseudouridine synthase activity
H7F25_RS06325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H7F25_RS06330	COG2233	PERMEase
H7F25_RS06335	COG0540	Belongs to the ATCase OTCase family
H7F25_RS06340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7F25_RS06345	COG0505	Belongs to the CarA family
H7F25_RS06350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7F25_RS06355	COG0543	2 iron, 2 sulfur cluster binding
H7F25_RS06360	COG0167	dihydroorotate dehydrogenase activity
H7F25_RS06365	COG0284	orotidine-5'-phosphate decarboxylase activity
H7F25_RS06370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7F25_RS06380	COG0175	sulfate reduction
H7F25_RS06385	COG0306	phosphate transporter
H7F25_RS06390	COG2046	Belongs to the sulfate adenylyltransferase family
H7F25_RS06395	COG0529	Catalyzes the synthesis of activated sulfate
H7F25_RS06400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7F25_RS06405	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H7F25_RS06410	COG1648	precorrin-2 dehydrogenase activity
H7F25_RS06420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H7F25_RS06425	COG1561	YicC-like family, N-terminal region
H7F25_RS06430	COG2052	Domain of unknown function (DUF370)
H7F25_RS06435	COG0194	GDP metabolic process
H7F25_RS06440	COG1758	RNA polymerase activity
H7F25_RS06445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7F25_RS06450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7F25_RS06455	COG0242	peptide deformylase activity
H7F25_RS06460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7F25_RS06465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7F25_RS06465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7F25_RS06470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7F25_RS06475	COG0631	protein serine/threonine phosphatase activity
H7F25_RS06480	COG0515	serine threonine protein kinase
H7F25_RS06480	COG2815	serine threonine protein kinase
H7F25_RS06485	COG1162	GTPase activity
H7F25_RS06490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7F25_RS06495	COG1564	THIamine pyrophosphokinase
H7F25_RS06505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7F25_RS06510	COG1302	Protein conserved in bacteria
H7F25_RS06515	COG1461	Dihydroxyacetone kinase
H7F25_RS06520	COG1760	l-serine dehydratase
H7F25_RS06525	COG1760	l-serine dehydratase
H7F25_RS06530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7F25_RS06535	COG1349	DNA-binding transcription factor activity
H7F25_RS06540	COG0416	fatty acid biosynthetic process
H7F25_RS06545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7F25_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS06555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F25_RS06565	COG1196	nuclear chromosome segregation
H7F25_RS06570	COG0552	protein localization to endoplasmic reticulum
H7F25_RS06575	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H7F25_RS06580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7F25_RS06585	COG0228	four-way junction DNA binding
H7F25_RS06590	COG1837	Belongs to the UPF0109 family
H7F25_RS06600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7F25_RS06605	COG0336	Belongs to the RNA methyltransferase TrmD family
H7F25_RS06610	COG0335	large ribosomal subunit rRNA binding
H7F25_RS06615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7F25_RS06620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7F25_RS06630	COG2257	FlhB HrpN YscU SpaS Family
H7F25_RS06635	COG0045	succinate-CoA ligase (ADP-forming) activity
H7F25_RS06640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7F25_RS06645	COG0758	DNA mediated transformation
H7F25_RS06650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7F25_RS06655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H7F25_RS06660	COG4974	Belongs to the 'phage' integrase family
H7F25_RS06665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7F25_RS06670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7F25_RS06675	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H7F25_RS06680	COG1815	bacterial-type flagellum-dependent cell motility
H7F25_RS06685	COG1558	bacterial-type flagellum-dependent cell motility
H7F25_RS06690	COG1677	Flagellar hook-basal body complex protein FliE
H7F25_RS06695	COG1766	The M ring may be actively involved in energy transduction
H7F25_RS06700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7F25_RS06705	COG1317	bacterial-type flagellum organization
H7F25_RS06710	COG1157	protein secretion by the type III secretion system
H7F25_RS06715	COG2882	bacterial-type flagellum organization
H7F25_RS06720	COG3334	PFAM MgtE intracellular
H7F25_RS06725	COG3144	bacterial-type flagellum assembly
H7F25_RS06730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7F25_RS06735	COG4786	Flagellar basal body rod
H7F25_RS06740	COG1582	Flagellar protein (FlbD)
H7F25_RS06745	COG1580	Controls the rotational direction of flagella during chemotaxis
H7F25_RS06750	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7F25_RS06755	COG1776	CheC inhibitor of MCP methylation
H7F25_RS06755	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7F25_RS06760	COG2201	protein-glutamate methylesterase activity
H7F25_RS06765	COG3190	flagellar
H7F25_RS06770	COG1338	Plays a role in the flagellum-specific transport system
H7F25_RS06775	COG1987	bacterial-type flagellum assembly
H7F25_RS06780	COG1684	flagellar biosynthetic protein fliR
H7F25_RS06785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7F25_RS06790	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7F25_RS06795	COG1419	protein localization to endoplasmic reticulum
H7F25_RS06800	COG0455	bacterial-type flagellum organization
H7F25_RS06805	COG2201	protein-glutamate methylesterase activity
H7F25_RS06810	COG0643	Histidine kinase
H7F25_RS06810	COG2198	Histidine kinase
H7F25_RS06815	COG0835	chemotaxis
H7F25_RS06820	COG1776	CheC inhibitor of MCP methylation
H7F25_RS06830	COG1191	sigma factor activity
H7F25_RS06845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7F25_RS06850	COG0528	UMP kinase activity
H7F25_RS06855	COG0233	cytoplasmic translational termination
H7F25_RS06860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7F25_RS06865	COG4589	Belongs to the CDS family
H7F25_RS06870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7F25_RS06875	COG0750	zinc metalloprotease
H7F25_RS06880	COG0442	prolyl-tRNA aminoacylation
H7F25_RS06885	COG2176	DNA-directed DNA polymerase activity
H7F25_RS06900	COG3693	PFAM glycoside hydrolase, family 10
H7F25_RS06910	COG0779	Required for maturation of 30S ribosomal subunits
H7F25_RS06915	COG0195	Participates in both transcription termination and antitermination
H7F25_RS06920	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H7F25_RS06925	COG1358	cellular component organization or biogenesis
H7F25_RS06930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7F25_RS06935	COG1550	Protein conserved in bacteria
H7F25_RS06940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7F25_RS06945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7F25_RS06950	COG0196	riboflavin kinase activity
H7F25_RS06955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7F25_RS06960	COG1185	polyribonucleotide nucleotidyltransferase activity
H7F25_RS06965	COG0726	polysaccharide deacetylase
H7F25_RS06970	COG0612	Peptidase, M16
H7F25_RS06980	COG1873	PFAM PRC-barrel domain
H7F25_RS06985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F25_RS06990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7F25_RS06995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7F25_RS07000	COG0527	aspartate kinase activity
H7F25_RS07010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H7F25_RS07015	COG0740	serine-type endopeptidase activity
H7F25_RS07025	COG1674	ftsk spoiiie
H7F25_RS07025	COG4980	gas vesicle protein
H7F25_RS07030	COG2188	Transcriptional regulator
H7F25_RS07035	COG2814	Major facilitator Superfamily
H7F25_RS07040	COG1033	growth of symbiont in host cell
H7F25_RS07040	COG2409	Drug exporters of the RND superfamily
H7F25_RS07045	COG0612	Peptidase, M16
H7F25_RS07050	COG0612	Peptidase, M16
H7F25_RS07060	COG2409	Drug exporters of the RND superfamily
H7F25_RS07060	COG1033	growth of symbiont in host cell
H7F25_RS07065	COG0300	oxidoreductase activity
H7F25_RS07080	COG1426	Protein conserved in bacteria
H7F25_RS07085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7F25_RS07090	COG1058	Belongs to the CinA family
H7F25_RS07090	COG1546	Belongs to the CinA family
H7F25_RS07095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7F25_RS07100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7F25_RS07105	COG1418	mRNA catabolic process
H7F25_RS07110	COG1692	metallophosphoesterase
H7F25_RS07115	COG2359	stage V sporulation protein S
H7F25_RS07120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7F25_RS07125	COG1063	alcohol dehydrogenase
H7F25_RS07130	COG0156	8-amino-7-oxononanoate synthase activity
H7F25_RS07140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7F25_RS07145	COG4550	Control of competence regulator ComK, YlbF/YmcA
H7F25_RS07155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7F25_RS07160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7F25_RS07180	COG1329	Transcriptional regulator
H7F25_RS07185	COG4195	phage-related replication protein
H7F25_RS07190	COG0457	Tetratricopeptide repeat
H7F25_RS07195	COG1404	Belongs to the peptidase S8 family
H7F25_RS07200	COG4195	phage-related replication protein
H7F25_RS07205	COG1764	response to oxidative stress
H7F25_RS07210	COG2076	Multidrug Resistance protein
H7F25_RS07235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7F25_RS07240	COG1923	regulation of RNA biosynthetic process
H7F25_RS07255	COG1780	Probably involved in ribonucleotide reductase function
H7F25_RS07260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F25_RS07265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7F25_RS07270	COG4112	unkown
H7F25_RS07275	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS07280	COG0464	growth
H7F25_RS07285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7F25_RS07290	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H7F25_RS07295	COG0789	Transcriptional regulator
H7F25_RS07300	COG0174	glutamine synthetase
H7F25_RS07310	COG4282	regulation of fungal-type cell wall biogenesis
H7F25_RS07335	COG0457	Tetratricopeptide repeat
H7F25_RS07340	COG5444	nuclease activity
H7F25_RS07360	COG5646	InterPro IPR014922
H7F25_RS07365	COG0457	Tetratricopeptide repeat
H7F25_RS07370	COG3619	membrane
H7F25_RS07375	COG3285	dna ligase
H7F25_RS07375	COG1793	dna ligase
H7F25_RS07380	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H7F25_RS07385	COG4876	unkown
H7F25_RS07390	COG0346	lactoylglutathione lyase activity
H7F25_RS07395	COG1959	2 iron, 2 sulfur cluster binding
H7F25_RS07400	COG0702	epimerase
H7F25_RS07420	COG2323	membrane
H7F25_RS07425	COG1309	transcriptional regulator
H7F25_RS07430	COG2124	cytochrome p450
H7F25_RS07430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7F25_RS07435	COG3591	Belongs to the peptidase S1B family
H7F25_RS07440	COG3209	COG3209 Rhs family protein
H7F25_RS07445	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F25_RS07460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7F25_RS07465	COG1388	LysM domain
H7F25_RS07470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7F25_RS07475	COG4224	UPF0291 protein
H7F25_RS07480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7F25_RS07490	COG3763	UPF0154 protein
H7F25_RS07500	COG0785	Cytochrome C biogenesis protein
H7F25_RS07505	COG4846	Membrane protein involved in cytochrome C biogenesis
H7F25_RS07515	COG0071	Belongs to the small heat shock protein (HSP20) family
H7F25_RS07530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H7F25_RS07535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F25_RS07555	COG0824	Thioesterase
H7F25_RS07565	COG4841	protein insertion into membrane
H7F25_RS07570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7F25_RS07575	COG1832	CoA-binding protein
H7F25_RS07580	COG0187	DNA topoisomerase II activity
H7F25_RS07585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7F25_RS07595	COG0738	Major facilitator superfamily
H7F25_RS07600	COG0110	maltose O-acetyltransferase activity
H7F25_RS07605	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7F25_RS07610	COG1733	regulation of RNA biosynthetic process
H7F25_RS07620	COG1139	Iron-sulfur cluster binding protein
H7F25_RS07625	COG0247	lactate metabolic process
H7F25_RS07640	COG3292	Two component regulator propeller
H7F25_RS07640	COG0745	RESPONSE REGULATOR receiver
H7F25_RS07640	COG2205	protein histidine kinase activity
H7F25_RS07645	COG2197	response regulator
H7F25_RS07650	COG4585	Histidine kinase
H7F25_RS07655	COG2409	Drug exporters of the RND superfamily
H7F25_RS07660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F25_RS07665	COG0251	oxidation-reduction process
H7F25_RS07705	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H7F25_RS07720	COG0583	DNA-binding transcription factor activity
H7F25_RS07740	COG0657	acetylesterase activity
H7F25_RS07745	COG0789	Transcriptional regulator
H7F25_RS07750	COG2723	6-phospho-beta-galactosidase activity
H7F25_RS07755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS07755	COG1263	PTS System
H7F25_RS07755	COG2190	(PTS) system
H7F25_RS07770	COG2205	protein histidine kinase activity
H7F25_RS07775	COG0745	RESPONSE REGULATOR receiver
H7F25_RS07785	COG3507	Belongs to the glycosyl hydrolase 43 family
H7F25_RS07790	COG1012	belongs to the aldehyde dehydrogenase family
H7F25_RS07795	COG1486	melibiose metabolic process
H7F25_RS07800	COG0395	ABC-type sugar transport system, permease component
H7F25_RS07805	COG1175	transmembrane transport
H7F25_RS07810	COG1653	transport
H7F25_RS07815	COG1609	Transcriptional regulator
H7F25_RS07820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7F25_RS07835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS07865	COG5444	nuclease activity
H7F25_RS07870	COG1846	Transcriptional regulator
H7F25_RS07875	COG2814	Major facilitator Superfamily
H7F25_RS07885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS07885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F25_RS07885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F25_RS07890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS07890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F25_RS07890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F25_RS07895	COG1105	Belongs to the carbohydrate kinase PfkB family
H7F25_RS07905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F25_RS07935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7F25_RS07940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F25_RS07945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7F25_RS07950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7F25_RS07955	COG1024	Enoyl-CoA hydratase
H7F25_RS07960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7F25_RS07965	COG0511	ligase activity, forming carbon-carbon bonds
H7F25_RS07970	COG0439	Biotin carboxylase
H7F25_RS07975	COG0318	PFAM AMP-dependent synthetase and ligase
H7F25_RS07980	COG1960	acyl-CoA dehydrogenase activity
H7F25_RS07985	COG1649	PFAM Uncharacterised BCR, COG1649
H7F25_RS07990	COG2365	Tyrosine phosphatase family
H7F25_RS07995	COG1349	DNA-binding transcription factor activity
H7F25_RS08005	COG3835	regulator
H7F25_RS08010	COG0277	FAD linked oxidase domain protein
H7F25_RS08015	COG0247	lactate metabolic process
H7F25_RS08040	COG0166	Belongs to the GPI family
H7F25_RS08045	COG2246	polysaccharide biosynthetic process
H7F25_RS08050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7F25_RS08055	COG0586	Pfam SNARE associated Golgi protein
H7F25_RS08060	COG1587	Uroporphyrinogen-III synthase
H7F25_RS08070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F25_RS08085	COG0534	Mate efflux family protein
H7F25_RS08090	COG2027	D-alanyl-D-alanine carboxypeptidase
H7F25_RS08095	COG4677	pectinesterase activity
H7F25_RS08100	COG2323	membrane
H7F25_RS08105	COG2146	nitrite reductase [NAD(P)H] activity
H7F25_RS08110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F25_RS08115	COG0243	molybdopterin cofactor binding
H7F25_RS08120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7F25_RS08125	COG2223	nitrite transmembrane transporter activity
H7F25_RS08130	COG0493	'glutamate synthase
H7F25_RS08135	COG0069	glutamate synthase activity
H7F25_RS08135	COG0070	glutamate synthase
H7F25_RS08135	COG0067	glutamate synthase
H7F25_RS08140	COG0583	DNA-binding transcription factor activity
H7F25_RS08150	COG1132	(ABC) transporter
H7F25_RS08155	COG0789	Transcriptional regulator
H7F25_RS08155	COG4978	Transcriptional regulator
H7F25_RS08160	COG0454	-acetyltransferase
H7F25_RS08165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7F25_RS08170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7F25_RS08185	COG0243	molybdopterin cofactor binding
H7F25_RS08195	COG1070	Carbohydrate kinase
H7F25_RS08200	COG2115	Belongs to the xylose isomerase family
H7F25_RS08215	COG2211	Major facilitator Superfamily
H7F25_RS08220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F25_RS08225	COG1994	Peptidase M50
H7F25_RS08245	COG1309	transcriptional regulator
H7F25_RS08250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F25_RS08255	COG3708	Transcriptional regulator
H7F25_RS08260	COG2378	regulation of single-species biofilm formation
H7F25_RS08270	COG0640	Transcriptional regulator
H7F25_RS08275	COG0531	amino acid
H7F25_RS08280	COG0741	lytic transglycosylase activity
H7F25_RS08285	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7F25_RS08290	COG2079	MmgE PrpD family protein
H7F25_RS08295	COG0372	Belongs to the citrate synthase family
H7F25_RS08300	COG2322	membrane
H7F25_RS08310	COG3584	3D domain protein
H7F25_RS08310	COG1388	LysM domain
H7F25_RS08315	COG0514	ATP-dependent DNA helicase (RecQ)
H7F25_RS08325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7F25_RS08350	COG1012	belongs to the aldehyde dehydrogenase family
H7F25_RS08355	COG1657	PFAM Prenyltransferase squalene oxidase
H7F25_RS08360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7F25_RS08365	COG0385	Bile acid
H7F25_RS08370	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F25_RS08375	COG0567	Dehydrogenase, E1 component
H7F25_RS08380	COG4548	von Willebrand factor, type A
H7F25_RS08385	COG0714	Associated with various cellular activities
H7F25_RS08390	COG2032	superoxide dismutase activity
H7F25_RS08395	COG1388	LysM domain
H7F25_RS08395	COG0791	NLP P60 protein
H7F25_RS08400	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H7F25_RS08405	COG0534	Mate efflux family protein
H7F25_RS08410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F25_RS08415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F25_RS08425	COG2962	Rard protein
H7F25_RS08440	COG1733	regulation of RNA biosynthetic process
H7F25_RS08445	COG0778	Nitroreductase
H7F25_RS08455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F25_RS08460	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H7F25_RS08465	COG3409	Peptidoglycan-binding domain 1 protein
H7F25_RS08465	COG0793	Belongs to the peptidase S41A family
H7F25_RS08470	COG2226	methyltransferase
H7F25_RS08480	COG1876	peptidase activity
H7F25_RS08485	COG0813	purine-nucleoside phosphorylase activity
H7F25_RS08495	COG0671	phosphoesterase, PA-phosphatase related
H7F25_RS08510	COG4479	Belongs to the UPF0346 family
H7F25_RS08520	COG1509	lysine 2,3-aminomutase activity
H7F25_RS08525	COG3829	transcription factor binding
H7F25_RS08530	COG0463	Glycosyl transferase, family 2
H7F25_RS08545	COG4641	Protein conserved in bacteria
H7F25_RS08555	COG1086	Polysaccharide biosynthesis protein
H7F25_RS08560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7F25_RS08565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7F25_RS08570	COG1846	Transcriptional regulator
H7F25_RS08590	COG4698	Protein conserved in bacteria
H7F25_RS08595	COG2755	lipolytic protein G-D-S-L family
H7F25_RS08600	COG1999	signal sequence binding
H7F25_RS08615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7F25_RS08620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7F25_RS08625	COG1272	protein, Hemolysin III
H7F25_RS08630	COG0204	Acyl-transferase
H7F25_RS08635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7F25_RS08640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7F25_RS08645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7F25_RS08655	COG2521	methyltransferase
H7F25_RS08655	COG2136	Putative SAM-dependent methyltransferase
H7F25_RS08665	COG0129	dihydroxy-acid dehydratase activity
H7F25_RS08670	COG1413	lyase activity
H7F25_RS08675	COG1418	mRNA catabolic process
H7F25_RS08680	COG0386	Belongs to the glutathione peroxidase family
H7F25_RS08685	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7F25_RS08690	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7F25_RS08695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7F25_RS08705	COG1278	Cold shock
H7F25_RS08720	COG0328	RNA-DNA hybrid ribonuclease activity
H7F25_RS08725	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7F25_RS08730	COG0328	RNA-DNA hybrid ribonuclease activity
H7F25_RS08740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F25_RS08750	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H7F25_RS08760	COG1755	Isoprenylcysteine carboxyl methyltransferase
H7F25_RS08765	COG3424	synthase
H7F25_RS08775	COG0726	polysaccharide deacetylase
H7F25_RS08780	COG2233	PERMEase
H7F25_RS08785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7F25_RS08790	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7F25_RS08795	COG1199	ATP-dependent helicase activity
H7F25_RS08805	COG0116	Belongs to the methyltransferase superfamily
H7F25_RS08815	COG3599	regulation of cell shape
H7F25_RS08820	COG4474	Belongs to the UPF0398 family
H7F25_RS08830	COG3359	exonuclease
H7F25_RS08835	COG1205	dead DEAH box helicase
H7F25_RS08835	COG1111	helicase
H7F25_RS08840	COG1902	pentaerythritol trinitrate reductase activity
H7F25_RS08845	COG2190	(PTS) system
H7F25_RS08850	COG0071	Belongs to the small heat shock protein (HSP20) family
H7F25_RS08880	COG3331	DNA recombination
H7F25_RS08885	COG4499	WXG100 protein secretion system (Wss), protein YukC
H7F25_RS08885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F25_RS08895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7F25_RS08900	COG3935	DnaD domain protein
H7F25_RS08905	COG0017	Asparaginyl-tRNA synthetase
H7F25_RS08910	COG5353	protein conserved in bacteria
H7F25_RS08920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7F25_RS08920	COG1199	ATP-dependent helicase activity
H7F25_RS08925	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H7F25_RS08930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7F25_RS08935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7F25_RS08945	COG0617	tRNA 3'-terminal CCA addition
H7F25_RS08950	COG0438	transferase activity, transferring glycosyl groups
H7F25_RS08955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7F25_RS08960	COG1803	Methylglyoxal synthase
H7F25_RS08965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7F25_RS08970	COG1694	Mazg nucleotide pyrophosphohydrolase
H7F25_RS08975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F25_RS08985	COG4347	Protein of unknown function (DUF1405)
H7F25_RS08990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7F25_RS08990	COG2010	Cytochrome c
H7F25_RS08995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7F25_RS09000	COG0723	plastoquinol--plastocyanin reductase activity
H7F25_RS09010	COG5582	Belongs to the UPF0302 family
H7F25_RS09015	COG0457	Tetratricopeptide repeat
H7F25_RS09020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7F25_RS09025	COG0287	Prephenate dehydrogenase
H7F25_RS09030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7F25_RS09035	COG0159	tryptophan synthase activity
H7F25_RS09040	COG0133	tryptophan synthase activity
H7F25_RS09050	COG0134	indole-3-glycerol-phosphate synthase activity
H7F25_RS09065	COG4401	Chorismate mutase type I
H7F25_RS09070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7F25_RS09075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7F25_RS09080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7F25_RS09085	COG0105	UTP biosynthetic process
H7F25_RS09090	COG0142	geranyltranstransferase activity
H7F25_RS09095	COG2226	methyltransferase
H7F25_RS09100	COG0142	geranyltranstransferase activity
H7F25_RS09110	COG0302	gtp cyclohydrolase
H7F25_RS09115	COG0776	regulation of translation
H7F25_RS09120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H7F25_RS09135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7F25_RS09140	COG1160	GTP binding
H7F25_RS09165	COG1304	FMN binding
H7F25_RS09170	COG0539	negative regulation of cytoplasmic translation
H7F25_RS09175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7F25_RS09185	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H7F25_RS09190	COG2959	enzyme of heme biosynthesis
H7F25_RS09195	COG3773	Cell wall hydrolase
H7F25_RS09195	COG3409	Peptidoglycan-binding domain 1 protein
H7F25_RS09200	COG2339	peptidase activity
H7F25_RS09205	COG0492	ferredoxin-NADP+ reductase activity
H7F25_RS09210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F25_RS09215	COG4862	establishment of competence for transformation
H7F25_RS09220	COG1408	metallophosphoesterase
H7F25_RS09230	COG1388	LysM domain
H7F25_RS09235	COG1266	CAAX protease self-immunity
H7F25_RS09240	COG0514	ATP-dependent DNA helicase (RecQ)
H7F25_RS09245	COG4955	Helix-turn-helix domain
H7F25_RS09250	COG1141	Ferredoxin
H7F25_RS09255	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H7F25_RS09260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7F25_RS09265	COG3409	Peptidoglycan-binding domain 1 protein
H7F25_RS09265	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS09275	COG1595	DNA-templated transcription, initiation
H7F25_RS09280	COG5002	protein histidine kinase activity
H7F25_RS09285	COG0745	RESPONSE REGULATOR receiver
H7F25_RS09290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7F25_RS09295	COG1333	cytochrome c biogenesis protein
H7F25_RS09300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F25_RS09305	COG1187	pseudouridine synthase activity
H7F25_RS09310	COG0700	Nucleoside recognition
H7F25_RS09315	COG2715	membrane protein required for spore maturation
H7F25_RS09320	COG1686	Belongs to the peptidase S11 family
H7F25_RS09330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7F25_RS09335	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H7F25_RS09345	COG1547	Domain of unknown function (DUF309)
H7F25_RS09350	COG0456	acetyltransferase
H7F25_RS09355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7F25_RS09360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F25_RS09360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F25_RS09365	COG0307	riboflavin synthase, alpha
H7F25_RS09385	COG2814	Major facilitator Superfamily
H7F25_RS09390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7F25_RS09395	COG4086	secreted protein
H7F25_RS09400	COG0019	diaminopimelate decarboxylase activity
H7F25_RS09405	COG0697	spore germination
H7F25_RS09420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7F25_RS09440	COG1191	sigma factor activity
H7F25_RS09445	COG2172	sigma factor antagonist activity
H7F25_RS09455	COG1686	Belongs to the peptidase S11 family
H7F25_RS09460	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7F25_RS09465	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7F25_RS09470	COG4974	Belongs to the 'phage' integrase family
H7F25_RS09480	COG0735	belongs to the Fur family
H7F25_RS09485	COG1300	Membrane
H7F25_RS09490	COG1404	Belongs to the peptidase S8 family
H7F25_RS09500	COG2153	protein acetylation
H7F25_RS09505	COG1379	DNA repair
H7F25_RS09510	COG0494	nUDIX hydrolase
H7F25_RS09515	COG0667	Aldo Keto reductase
H7F25_RS09530	COG1073	alpha beta
H7F25_RS09535	COG0457	Tetratricopeptide repeat
H7F25_RS09550	COG4918	Iron-sulphur cluster biosynthesis
H7F25_RS09555	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H7F25_RS09555	COG0456	acetyltransferase
H7F25_RS09560	COG0456	acetyltransferase
H7F25_RS09570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7F25_RS09580	COG2211	Major facilitator Superfamily
H7F25_RS09585	COG1072	(Pantothenic acid kinase))
H7F25_RS09590	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7F25_RS09595	COG0300	oxidoreductase activity
H7F25_RS09600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F25_RS09605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F25_RS09615	COG4187	Peptidase family M20/M25/M40
H7F25_RS09620	COG1902	pentaerythritol trinitrate reductase activity
H7F25_RS09625	COG0596	Alpha beta hydrolase
H7F25_RS09630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F25_RS09640	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7F25_RS09645	COG2188	Transcriptional regulator
H7F25_RS09650	COG2723	6-phospho-beta-galactosidase activity
H7F25_RS09655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F25_RS09660	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7F25_RS09665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F25_RS09670	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS09680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H7F25_RS09685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7F25_RS09700	COG0706	membrane insertase activity
H7F25_RS09710	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7F25_RS09715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7F25_RS09720	COG0346	lactoylglutathione lyase activity
H7F25_RS09730	COG1376	ErfK ybiS ycfS ynhG family protein
H7F25_RS09735	COG4129	membrane
H7F25_RS09740	COG1126	abc transporter atp-binding protein
H7F25_RS09745	COG0765	amino acid transport
H7F25_RS09750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F25_RS09760	COG1597	lipid kinase activity
H7F25_RS09770	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7F25_RS09775	COG0022	dehydrogenase e1 component
H7F25_RS09780	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7F25_RS09785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7F25_RS09790	COG3426	butyrate kinase activity
H7F25_RS09795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F25_RS09800	COG0280	phosphate acetyltransferase
H7F25_RS09805	COG3290	protein histidine kinase activity
H7F25_RS09805	COG3829	transcription factor binding
H7F25_RS09815	COG0584	glycerophosphoryl diester phosphodiesterase
H7F25_RS09820	COG0457	Tetratricopeptide repeat
H7F25_RS09830	COG0745	RESPONSE REGULATOR receiver
H7F25_RS09835	COG0750	zinc metalloprotease
H7F25_RS09840	COG0497	DNA recombination
H7F25_RS09845	COG1438	arginine binding
H7F25_RS09850	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H7F25_RS09855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7F25_RS09860	COG0142	geranyltranstransferase activity
H7F25_RS09865	COG1722	exodeoxyribonuclease VII activity
H7F25_RS09870	COG1570	exodeoxyribonuclease VII activity
H7F25_RS09875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7F25_RS09880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7F25_RS09885	COG1302	Protein conserved in bacteria
H7F25_RS09890	COG0439	Biotin carboxylase
H7F25_RS09895	COG0511	ligase activity, forming carbon-carbon bonds
H7F25_RS09935	COG3854	ATPases associated with a variety of cellular activities
H7F25_RS09945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7F25_RS09950	COG0006	proline dipeptidase activity
H7F25_RS09955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7F25_RS09965	COG3872	metal-dependent enzyme
H7F25_RS09975	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7F25_RS09980	COG1321	iron dependent repressor
H7F25_RS09985	COG0095	Lipoate-protein ligase
H7F25_RS09990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F25_RS09995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7F25_RS10000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7F25_RS10005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7F25_RS10010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7F25_RS10035	COG0681	Belongs to the peptidase S26 family
H7F25_RS10070	COG4970	Tfp pilus assembly protein FimT
H7F25_RS10075	COG4537	Required for transformation and DNA binding
H7F25_RS10080	COG1459	type II secretion system
H7F25_RS10085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7F25_RS10090	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F25_RS10100	COG1393	Belongs to the ArsC family
H7F25_RS10110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F25_RS10120	COG0011	TIGRFAM Protein of
H7F25_RS10125	COG2814	Major facilitator Superfamily
H7F25_RS10130	COG2866	Carboxypeptidase
H7F25_RS10135	COG1368	sulfuric ester hydrolase activity
H7F25_RS10140	COG1940	carbohydrate kinase activity
H7F25_RS10145	COG4483	Protein conserved in bacteria
H7F25_RS10150	COG0705	Rhomboid family
H7F25_RS10150	COG0457	Tetratricopeptide repeat
H7F25_RS10160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7F25_RS10165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7F25_RS10175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7F25_RS10180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7F25_RS10185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7F25_RS10190	COG0581	inorganic phosphate transmembrane transporter activity
H7F25_RS10195	COG0573	inorganic phosphate transmembrane transporter activity
H7F25_RS10200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7F25_RS10205	COG0768	penicillin binding
H7F25_RS10210	COG0477	Major facilitator Superfamily
H7F25_RS10215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7F25_RS10220	COG2839	Protein conserved in bacteria
H7F25_RS10225	COG5521	maltodextrose utilization protein MalA
H7F25_RS10230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F25_RS10235	COG1388	LysM domain
H7F25_RS10240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7F25_RS10245	COG4709	membrane
H7F25_RS10250	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H7F25_RS10255	COG1940	carbohydrate kinase activity
H7F25_RS10260	COG0735	belongs to the Fur family
H7F25_RS10265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7F25_RS10270	COG1121	(ABC) transporter
H7F25_RS10275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F25_RS10290	COG0513	Belongs to the DEAD box helicase family
H7F25_RS10300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7F25_RS10305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7F25_RS10310	COG2384	SAM-dependent methyltransferase
H7F25_RS10315	COG2010	Cytochrome c
H7F25_RS10320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7F25_RS10325	COG0358	DNA primase activity
H7F25_RS10330	COG1671	Belongs to the UPF0178 family
H7F25_RS10335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7F25_RS10340	COG0517	IMP dehydrogenase activity
H7F25_RS10345	COG0751	glycine-tRNA ligase activity
H7F25_RS10350	COG0752	glycyl-tRNA synthetase alpha subunit
H7F25_RS10355	COG1381	Involved in DNA repair and RecF pathway recombination
H7F25_RS10365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H7F25_RS10370	COG0295	cytidine deaminase activity
H7F25_RS10375	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7F25_RS10380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7F25_RS10385	COG1480	7TM receptor with intracellular HD hydrolase
H7F25_RS10390	COG1702	phosphate starvation-inducible protein PhoH
H7F25_RS10395	COG0561	phosphatase activity
H7F25_RS10410	COG4864	UPF0365 protein
H7F25_RS10415	COG1030	water channel activity
H7F25_RS10420	COG1610	YqeY-like protein
H7F25_RS10430	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7F25_RS10435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7F25_RS10440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7F25_RS10445	COG2264	protein methyltransferase activity
H7F25_RS10450	COG0484	heat shock protein binding
H7F25_RS10455	COG0443	Heat shock 70 kDa protein
H7F25_RS10460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7F25_RS10465	COG1420	regulation of RNA biosynthetic process
H7F25_RS10470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7F25_RS10475	COG0481	GTPase activity
H7F25_RS10485	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS10490	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7F25_RS10495	COG0268	Binds directly to 16S ribosomal RNA
H7F25_RS10500	COG1466	dna polymerase III delta subunit
H7F25_RS10510	COG0658	competence protein
H7F25_RS10510	COG2333	competence protein COMEC
H7F25_RS10515	COG2131	deaminase
H7F25_RS10520	COG1555	photosystem II stabilization
H7F25_RS10525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7F25_RS10530	COG2226	methyltransferase
H7F25_RS10535	COG0799	negative regulation of ribosome biogenesis
H7F25_RS10540	COG1713	HD superfamily hydrolase involved in NAD metabolism
H7F25_RS10545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7F25_RS10550	COG1534	Rna-binding protein
H7F25_RS10555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7F25_RS10560	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7F25_RS10565	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H7F25_RS10580	COG2755	lipolytic protein G-D-S-L family
H7F25_RS10590	COG0457	Tetratricopeptide repeat
H7F25_RS10600	COG2186	Transcriptional regulator
H7F25_RS10615	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS10620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7F25_RS10625	COG3959	Transketolase, thiamine diphosphate binding domain
H7F25_RS10650	COG0726	polysaccharide deacetylase
H7F25_RS10685	COG1131	(ABC) transporter
H7F25_RS10705	COG2160	L-arabinose isomerase activity
H7F25_RS10720	COG1609	Transcriptional regulator
H7F25_RS10730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7F25_RS10735	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H7F25_RS10740	COG1733	regulation of RNA biosynthetic process
H7F25_RS10745	COG0657	acetylesterase activity
H7F25_RS10760	COG1309	transcriptional regulator
H7F25_RS10765	COG0109	protoheme IX farnesyltransferase activity
H7F25_RS10770	COG2602	Beta-lactamase
H7F25_RS10775	COG1960	acyl-CoA dehydrogenase activity
H7F25_RS10780	COG1126	abc transporter atp-binding protein
H7F25_RS10790	COG0765	amino acid transport
H7F25_RS10800	COG3546	catalase activity
H7F25_RS10805	COG1063	alcohol dehydrogenase
H7F25_RS10815	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS10825	COG1115	amino acid carrier protein
H7F25_RS10830	COG0583	DNA-binding transcription factor activity
H7F25_RS10835	COG0842	Transport permease protein
H7F25_RS10840	COG1511	domain protein
H7F25_RS10840	COG0842	Transport permease protein
H7F25_RS10845	COG1131	(ABC) transporter
H7F25_RS10850	COG2226	methyltransferase
H7F25_RS10855	COG1063	alcohol dehydrogenase
H7F25_RS10860	COG2226	methyltransferase
H7F25_RS10885	COG0626	cystathionine gamma-synthase activity
H7F25_RS10890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F25_RS10895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7F25_RS10900	COG2226	methyltransferase
H7F25_RS10915	COG0768	penicillin binding
H7F25_RS10920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7F25_RS10930	COG0572	uridine kinase
H7F25_RS10935	COG0826	peptidase U32
H7F25_RS10940	COG0826	peptidase U32
H7F25_RS10945	COG4122	O-methyltransferase activity
H7F25_RS10950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7F25_RS10955	COG0183	Belongs to the thiolase family
H7F25_RS10960	COG0318	PFAM AMP-dependent synthetase and ligase
H7F25_RS10965	COG1268	BioY protein
H7F25_RS10970	COG3906	Belongs to the UPF0473 family
H7F25_RS10975	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7F25_RS10980	COG4472	Bacterial protein of unknown function (DUF965)
H7F25_RS10985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7F25_RS10990	COG0628	permease
H7F25_RS10995	COG1126	abc transporter atp-binding protein
H7F25_RS11000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F25_RS11005	COG0765	amino acid transport
H7F25_RS11010	COG0765	amino acid transport
H7F25_RS11025	COG3881	PFAM PRC-barrel domain
H7F25_RS11030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7F25_RS11035	COG0457	Tetratricopeptide repeat
H7F25_RS11040	COG0482	sulfurtransferase activity
H7F25_RS11045	COG1104	cysteine desulfurase activity
H7F25_RS11050	COG1959	2 iron, 2 sulfur cluster binding
H7F25_RS11055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7F25_RS11060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7F25_RS11075	COG0124	histidyl-tRNA synthetase
H7F25_RS11085	COG4991	sh3 domain protein
H7F25_RS11085	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS11085	COG3103	Sh3 type 3 domain protein
H7F25_RS11090	COG1490	D-aminoacyl-tRNA deacylase activity
H7F25_RS11095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7F25_RS11100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7F25_RS11105	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H7F25_RS11105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7F25_RS11110	COG5416	Lipopolysaccharide assembly protein A domain
H7F25_RS11115	COG0490	domain, Protein
H7F25_RS11120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7F25_RS11120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7F25_RS11130	COG2244	polysaccharide biosynthetic process
H7F25_RS11135	COG2323	membrane
H7F25_RS11145	COG1862	Preprotein translocase
H7F25_RS11150	COG0343	queuine tRNA-ribosyltransferase activity
H7F25_RS11155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7F25_RS11165	COG2255	four-way junction helicase activity
H7F25_RS11170	COG0632	four-way junction helicase activity
H7F25_RS11180	COG2112	serine threonine protein kinase
H7F25_RS11195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7F25_RS11210	COG1388	LysM domain
H7F25_RS11210	COG1388	LysM domain
H7F25_RS11215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7F25_RS11220	COG0157	Belongs to the NadC ModD family
H7F25_RS11225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7F25_RS11230	COG1104	cysteine desulfurase activity
H7F25_RS11235	COG1827	regulation of RNA biosynthetic process
H7F25_RS11240	COG0077	Prephenate dehydratase
H7F25_RS11245	COG4492	Belongs to the UPF0735 family
H7F25_RS11250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7F25_RS11255	COG3290	protein histidine kinase activity
H7F25_RS11260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7F25_RS11265	COG2868	ribosomal protein
H7F25_RS11270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7F25_RS11275	COG1994	Peptidase M50
H7F25_RS11280	COG0739	heme binding
H7F25_RS11285	COG2894	cell division
H7F25_RS11290	COG0850	regulation of cytokinetic process
H7F25_RS11295	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7F25_RS11305	COG1077	Cell shape determining protein MreB Mrl
H7F25_RS11310	COG2003	Belongs to the UPF0758 family
H7F25_RS11315	COG0424	maF-like protein
H7F25_RS11325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7F25_RS11330	COG0285	dihydrofolate synthase activity
H7F25_RS11335	COG0525	valine-tRNA ligase activity
H7F25_RS11340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7F25_RS11345	COG1388	LysM domain
H7F25_RS11350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7F25_RS11355	COG0113	porphobilinogen synthase activity
H7F25_RS11360	COG1587	Uroporphyrinogen-III synthase
H7F25_RS11365	COG0181	hydroxymethylbilane synthase activity
H7F25_RS11370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7F25_RS11375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7F25_RS11385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7F25_RS11390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7F25_RS11395	COG0470	DNA polymerase III
H7F25_RS11395	COG1067	ATP-dependent peptidase activity
H7F25_RS11400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7F25_RS11405	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7F25_RS11410	COG0457	Tetratricopeptide repeat
H7F25_RS11410	COG1477	protein flavinylation
H7F25_RS11415	COG0066	3-isopropylmalate dehydratase activity
H7F25_RS11420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7F25_RS11425	COG0473	3-isopropylmalate dehydrogenase activity
H7F25_RS11430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7F25_RS11435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7F25_RS11440	COG0440	acetolactate synthase activity
H7F25_RS11445	COG0028	Belongs to the TPP enzyme family
H7F25_RS11450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F25_RS11455	COG2706	6-phosphogluconolactonase activity
H7F25_RS11460	COG3339	Conserved Protein
H7F25_RS11465	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H7F25_RS11470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7F25_RS11475	COG1696	Membrane protein involved in D-alanine export
H7F25_RS11525	COG0622	Phosphoesterase
H7F25_RS11530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7F25_RS11535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7F25_RS11540	COG5401	PFAM Sporulation and spore germination
H7F25_RS11545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7F25_RS11550	COG1846	Transcriptional regulator
H7F25_RS11555	COG2197	response regulator
H7F25_RS11560	COG2851	Citrate transporter
H7F25_RS11565	COG0583	DNA-binding transcription factor activity
H7F25_RS11570	COG2828	Protein conserved in bacteria
H7F25_RS11580	COG0824	Thioesterase
H7F25_RS11585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7F25_RS11590	COG1053	succinate dehydrogenase
H7F25_RS11595	COG2009	succinate dehydrogenase
H7F25_RS11600	COG1719	4-vinyl reductase, 4VR
H7F25_RS11605	COG0527	aspartate kinase activity
H7F25_RS11610	COG0322	excinuclease ABC activity
H7F25_RS11615	COG3118	belongs to the thioredoxin family
H7F25_RS11620	COG3534	alpha-L-arabinofuranosidase
H7F25_RS11625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H7F25_RS11630	COG2086	electron transfer activity
H7F25_RS11635	COG1024	Enoyl-CoA hydratase
H7F25_RS11640	COG1309	transcriptional regulator
H7F25_RS11645	COG0318	PFAM AMP-dependent synthetase and ligase
H7F25_RS11655	COG3766	membrane
H7F25_RS11660	COG1193	negative regulation of DNA recombination
H7F25_RS11665	COG1796	DNA polymerase
H7F25_RS11665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7F25_RS11670	COG1286	toxin biosynthetic process
H7F25_RS11675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H7F25_RS11680	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7F25_RS11690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F25_RS11690	COG0072	phenylalanine-tRNA ligase activity
H7F25_RS11695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7F25_RS11700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7F25_RS11710	COG1966	Carbon starvation protein
H7F25_RS11715	COG1363	Peptidase, m42
H7F25_RS11725	COG3326	Membrane
H7F25_RS11730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7F25_RS11735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7F25_RS11740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7F25_RS11745	COG1346	cytolysis
H7F25_RS11755	COG3279	Response regulator of the LytR AlgR family
H7F25_RS11760	COG3275	phosphorelay sensor kinase activity
H7F25_RS11765	COG1011	Hydrolase
H7F25_RS11775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7F25_RS11785	COG0398	Pfam SNARE associated Golgi protein
H7F25_RS11790	COG1484	DNA-dependent DNA replication
H7F25_RS11795	COG3611	Membrane attachment protein
H7F25_RS11800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7F25_RS11810	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H7F25_RS11815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7F25_RS11820	COG0237	dephospho-CoA kinase activity
H7F25_RS11825	COG1971	Probably functions as a manganese efflux pump
H7F25_RS11830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7F25_RS11835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F25_RS11835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7F25_RS11840	COG5002	protein histidine kinase activity
H7F25_RS11845	COG0745	RESPONSE REGULATOR receiver
H7F25_RS11850	COG0039	L-malate dehydrogenase activity
H7F25_RS11855	COG0538	isocitrate dehydrogenase activity
H7F25_RS11860	COG0372	Belongs to the citrate synthase family
H7F25_RS11865	COG2707	UPF0756 membrane protein
H7F25_RS11870	COG0628	permease
H7F25_RS11875	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7F25_RS11885	COG0205	6-phosphofructokinase activity
H7F25_RS11890	COG0825	malonyl-CoA metabolic process
H7F25_RS11895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7F25_RS11900	COG0281	malic enzyme
H7F25_RS11905	COG0587	DNA-directed DNA polymerase activity
H7F25_RS11925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7F25_RS11935	COG4109	DRTGG domain
H7F25_RS11940	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7F25_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS11955	COG0165	Argininosuccinate lyase
H7F25_RS11960	COG0137	argininosuccinate synthase activity
H7F25_RS11965	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7F25_RS11970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7F25_RS11975	COG0827	DNA restriction-modification system
H7F25_RS11980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H7F25_RS11985	COG3874	Sporulation protein YtfJ
H7F25_RS11995	COG1714	RDD family
H7F25_RS12000	COG0616	signal peptide processing
H7F25_RS12005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7F25_RS12015	COG3239	Fatty acid desaturase
H7F25_RS12020	COG4585	Histidine kinase
H7F25_RS12025	COG2197	response regulator
H7F25_RS12030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F25_RS12035	COG0745	RESPONSE REGULATOR receiver
H7F25_RS12040	COG0642	Histidine kinase
H7F25_RS12045	COG1136	(ABC) transporter
H7F25_RS12050	COG0577	efflux transmembrane transporter activity
H7F25_RS12055	COG0402	S-adenosylhomocysteine deaminase activity
H7F25_RS12070	COG1279	arginine transmembrane transporter activity
H7F25_RS12090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7F25_RS12100	COG0301	tRNA thio-modification
H7F25_RS12105	COG1104	cysteine desulfurase activity
H7F25_RS12110	COG1114	Component of the transport system for branched-chain amino acids
H7F25_RS12115	COG1114	Component of the transport system for branched-chain amino acids
H7F25_RS12120	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H7F25_RS12125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7F25_RS12130	COG1309	transcriptional regulator
H7F25_RS12135	COG1956	GAF domain-containing protein
H7F25_RS12140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7F25_RS12145	COG1335	isochorismatase
H7F25_RS12155	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7F25_RS12160	COG2329	Antibiotic biosynthesis monooxygenase
H7F25_RS12165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7F25_RS12170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7F25_RS12175	COG0454	-acetyltransferase
H7F25_RS12180	COG0517	IMP dehydrogenase activity
H7F25_RS12185	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7F25_RS12190	COG1609	Transcriptional regulator
H7F25_RS12195	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H7F25_RS12195	COG1605	Chorismate mutase
H7F25_RS12200	COG3118	belongs to the thioredoxin family
H7F25_RS12205	COG4980	gas vesicle protein
H7F25_RS12210	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H7F25_RS12215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7F25_RS12220	COG1674	ftsk spoiiie
H7F25_RS12225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F25_RS12230	COG4848	Belongs to the UPF0354 family
H7F25_RS12235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F25_RS12250	COG1363	Peptidase, m42
H7F25_RS12255	COG5584	Small secreted protein
H7F25_RS12260	COG0281	malic enzyme
H7F25_RS12265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F25_RS12270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7F25_RS12280	COG0510	thiamine kinase activity
H7F25_RS12285	COG1597	lipid kinase activity
H7F25_RS12295	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H7F25_RS12300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F25_RS12305	COG3340	Belongs to the peptidase S51 family
H7F25_RS12310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7F25_RS12315	COG2252	PERMEase
H7F25_RS12320	COG1349	DNA-binding transcription factor activity
H7F25_RS12325	COG1187	pseudouridine synthase activity
H7F25_RS12330	COG2244	polysaccharide biosynthetic process
H7F25_RS12335	COG2081	HI0933 family
H7F25_RS12345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7F25_RS12350	COG3196	Protein conserved in bacteria
H7F25_RS12360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F25_RS12365	COG5578	integral membrane protein
H7F25_RS12370	COG0673	inositol 2-dehydrogenase activity
H7F25_RS12375	COG1653	transport
H7F25_RS12380	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H7F25_RS12385	COG4209	transmembrane transport
H7F25_RS12390	COG2207	Transcriptional regulator
H7F25_RS12395	COG1733	regulation of RNA biosynthetic process
H7F25_RS12400	COG2814	Major facilitator Superfamily
H7F25_RS12405	COG0656	L-ascorbic acid biosynthetic process
H7F25_RS12410	COG1653	transport
H7F25_RS12415	COG0395	ABC-type sugar transport system, permease component
H7F25_RS12420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F25_RS12425	COG1073	alpha beta
H7F25_RS12430	COG0495	leucyl-tRNA aminoacylation
H7F25_RS12440	COG2202	Pas domain
H7F25_RS12440	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F25_RS12445	COG2433	Pfam Transposase IS66
H7F25_RS12450	COG0577	efflux transmembrane transporter activity
H7F25_RS12455	COG1136	(ABC) transporter
H7F25_RS12465	COG1131	(ABC) transporter
H7F25_RS12470	COG1725	Transcriptional regulator
H7F25_RS12485	COG1242	4 iron, 4 sulfur cluster binding
H7F25_RS12490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H7F25_RS12500	COG2267	carboxylic ester hydrolase activity
H7F25_RS12505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7F25_RS12510	COG0367	asparagine synthase
H7F25_RS12515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H7F25_RS12520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7F25_RS12530	COG1506	peptidase
H7F25_RS12535	COG1233	COG1233 Phytoene dehydrogenase and related
H7F25_RS12555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7F25_RS12560	COG1116	anion transmembrane transporter activity
H7F25_RS12565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7F25_RS12570	COG0494	nUDIX hydrolase
H7F25_RS12575	COG2310	stress, protein
H7F25_RS12590	COG4824	toxin secretion phage lysis holin
H7F25_RS12600	COG0783	Belongs to the Dps family
H7F25_RS12615	COG1854	S-ribosylhomocysteine lyase activity
H7F25_RS12620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7F25_RS12625	COG0288	reversible hydration of carbon dioxide
H7F25_RS12630	COG3443	Belongs to the bacterial solute-binding protein 9 family
H7F25_RS12630	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7F25_RS12635	COG0254	rRNA binding
H7F25_RS12640	COG1271	oxidase subunit
H7F25_RS12645	COG1294	oxidase, subunit
H7F25_RS12660	COG4948	Mandelate Racemase Muconate Lactonizing
H7F25_RS12665	COG0318	PFAM AMP-dependent synthetase and ligase
H7F25_RS12670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7F25_RS12675	COG0596	Alpha beta hydrolase
H7F25_RS12680	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7F25_RS12685	COG1169	isochorismate synthase
H7F25_RS12690	COG1575	Belongs to the MenA family. Type 1 subfamily
H7F25_RS12695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7F25_RS12825	COG3859	Proton-coupled thiamine transporter YuaJ
H7F25_RS12830	COG1247	-acetyltransferase
H7F25_RS12835	COG3339	Conserved Protein
H7F25_RS12840	COG0772	Belongs to the SEDS family
H7F25_RS12845	COG0772	Belongs to the SEDS family
H7F25_RS12850	COG2268	Band 7 protein
H7F25_RS12855	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7F25_RS12860	COG2318	DinB family
H7F25_RS12865	COG1454	alcohol dehydrogenase
H7F25_RS12870	COG1012	belongs to the aldehyde dehydrogenase family
H7F25_RS12875	COG1510	regulation of RNA biosynthetic process
H7F25_RS12900	COG3409	Peptidoglycan-binding domain 1 protein
H7F25_RS12900	COG5632	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS12955	COG3778	Protein conserved in bacteria
H7F25_RS12960	COG3299	homolog of phage Mu protein gp47
H7F25_RS12965	COG3628	GPW Gp25 family protein
H7F25_RS12975	COG4193	domain, Protein
H7F25_RS12980	COG1652	LysM domain
H7F25_RS12985	COG3953	SLT domain
H7F25_RS12985	COG3953	SLT domain
H7F25_RS12985	COG5280	Phage tail tape measure protein TP901
H7F25_RS12985	COG5280	Phage tail tape measure protein TP901
H7F25_RS13040	COG4653	Phage capsid family
H7F25_RS13045	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7F25_RS13050	COG5518	Phage portal protein
H7F25_RS13055	COG1783	phage Terminase large subunit
H7F25_RS13060	COG5484	DNA packaging
H7F25_RS13065	COG1595	DNA-templated transcription, initiation
H7F25_RS13075	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
H7F25_RS13095	COG1396	sequence-specific DNA binding
H7F25_RS13105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7F25_RS13115	COG1968	undecaprenyl-diphosphatase activity
H7F25_RS13120	COG0628	permease
H7F25_RS13130	COG0673	inositol 2-dehydrogenase activity
H7F25_RS13135	COG0693	protein deglycase activity
H7F25_RS13140	COG0840	transmembrane signaling receptor activity
H7F25_RS13145	COG0840	transmembrane signaling receptor activity
H7F25_RS13150	COG0840	transmembrane signaling receptor activity
H7F25_RS13155	COG0840	transmembrane signaling receptor activity
H7F25_RS13170	COG2070	2-Nitropropane dioxygenase
H7F25_RS13175	COG0432	Pfam Uncharacterised protein family UPF0047
H7F25_RS13180	COG1253	flavin adenine dinucleotide binding
H7F25_RS13185	COG2738	Putative neutral zinc metallopeptidase
H7F25_RS13195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7F25_RS13210	COG0166	Belongs to the GPI family
H7F25_RS13215	COG1979	alcohol dehydrogenase
H7F25_RS13220	COG1979	alcohol dehydrogenase
H7F25_RS13225	COG2155	Conserved Protein
H7F25_RS13230	COG1098	S1 RNA binding domain
H7F25_RS13235	COG0436	Aminotransferase
H7F25_RS13240	COG1522	sequence-specific DNA binding
H7F25_RS13245	COG2267	carboxylic ester hydrolase activity
H7F25_RS13255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7F25_RS13260	COG2205	protein histidine kinase activity
H7F25_RS13275	COG5018	Exonuclease
H7F25_RS13280	COG2814	Major facilitator Superfamily
H7F25_RS13285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F25_RS13290	COG3011	Protein conserved in bacteria
H7F25_RS13300	COG3290	protein histidine kinase activity
H7F25_RS13305	COG4565	transcriptional regulatory protein
H7F25_RS13310	COG1744	ABC transporter substrate-binding protein PnrA-like
H7F25_RS13315	COG3845	ABC transporter
H7F25_RS13320	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7F25_RS13325	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7F25_RS13330	COG3493	citrate carrier protein
H7F25_RS13340	COG2111	Na H antiporter
H7F25_RS13340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H7F25_RS13345	COG2111	Na H antiporter
H7F25_RS13350	COG1006	Multisubunit Na H antiporter MnhC subunit
H7F25_RS13355	COG0651	ATP synthesis coupled electron transport
H7F25_RS13360	COG1863	multisubunit Na H antiporter MnhE subunit
H7F25_RS13365	COG2212	antiporter activity
H7F25_RS13370	COG1320	monovalent cation:proton antiporter activity
H7F25_RS13375	COG2050	protein possibly involved in aromatic compounds catabolism
H7F25_RS13380	COG2197	response regulator
H7F25_RS13385	COG4585	Histidine kinase
H7F25_RS13395	COG0142	geranyltranstransferase activity
H7F25_RS13410	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7F25_RS13415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7F25_RS13420	COG1335	isochorismatase
H7F25_RS13425	COG5506	Protein of unknown function (DUF1694)
H7F25_RS13445	COG0628	permease
H7F25_RS13460	COG1418	mRNA catabolic process
H7F25_RS13465	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS13475	COG1511	domain protein
H7F25_RS13480	COG1674	ftsk spoiiie
H7F25_RS13480	COG0433	COG0433 Predicted ATPase
H7F25_RS13485	COG4499	WXG100 protein secretion system (Wss), protein YukC
H7F25_RS13490	COG5417	Belongs to the EsaB family
H7F25_RS13495	COG4842	Belongs to the WXG100 family
H7F25_RS13500	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H7F25_RS13500	COG2508	Transcriptional regulator
H7F25_RS13505	COG0686	Belongs to the AlaDH PNT family
H7F25_RS13510	COG1268	BioY protein
H7F25_RS13515	COG4326	sporulation control protein
H7F25_RS13520	COG2056	Na+-H+ antiporter family
H7F25_RS13525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7F25_RS13530	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H7F25_RS13535	COG3584	3D domain protein
H7F25_RS13550	COG1252	NADH dehydrogenase
H7F25_RS13555	COG0492	ferredoxin-NADP+ reductase activity
H7F25_RS13565	COG0789	Transcriptional regulator
H7F25_RS13570	COG0316	Belongs to the HesB IscA family
H7F25_RS13575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7F25_RS13580	COG4844	belongs to the
H7F25_RS13585	COG1252	NADH dehydrogenase
H7F25_RS13595	COG4837	Protein of unknown function (DUF1462)
H7F25_RS13600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7F25_RS13605	COG1506	peptidase
H7F25_RS13605	COG0823	Involved in the tonB-independent uptake of proteins
H7F25_RS13605	COG4946	Tricorn protease homolog
H7F25_RS13610	COG0083	homoserine kinase activity
H7F25_RS13615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7F25_RS13620	COG0460	homoserine dehydrogenase
H7F25_RS13625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F25_RS13630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7F25_RS13635	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7F25_RS13640	COG0647	UMP catabolic process
H7F25_RS13645	COG2445	Protein of unknown function DUF86
H7F25_RS13650	COG4470	Protein conserved in bacteria
H7F25_RS13660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7F25_RS13665	COG0739	heme binding
H7F25_RS13675	COG3377	Domain of unknown function (DUF1805)
H7F25_RS13680	COG0737	Belongs to the 5'-nucleotidase family
H7F25_RS13685	COG1801	Protein of unknown function DUF72
H7F25_RS13690	COG2508	Transcriptional regulator
H7F25_RS13695	COG2140	Oxalate decarboxylase
H7F25_RS13700	COG2814	Major facilitator Superfamily
H7F25_RS13705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7F25_RS13710	COG2356	endonuclease I
H7F25_RS13720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F25_RS13725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F25_RS13730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F25_RS13740	COG0561	phosphatase activity
H7F25_RS13750	COG0642	Histidine kinase
H7F25_RS13750	COG5002	protein histidine kinase activity
H7F25_RS13755	COG0745	RESPONSE REGULATOR receiver
H7F25_RS13760	COG2311	Membrane
H7F25_RS13770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7F25_RS13780	COG1309	transcriptional regulator
H7F25_RS13785	COG0719	Fe-S assembly protein
H7F25_RS13790	COG0822	iron-sulfur transferase activity
H7F25_RS13795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7F25_RS13800	COG0719	Fe-S assembly protein
H7F25_RS13805	COG0396	ATPase activity
H7F25_RS13810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7F25_RS13815	COG1464	Belongs to the NlpA lipoprotein family
H7F25_RS13820	COG2011	ABC-type metal ion transport system permease component
H7F25_RS13825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7F25_RS13835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7F25_RS13840	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H7F25_RS13850	COG0509	glycine decarboxylation via glycine cleavage system
H7F25_RS13855	COG1393	Belongs to the ArsC family
H7F25_RS13860	COG1960	acyl-CoA dehydrogenase activity
H7F25_RS13865	COG0183	Belongs to the thiolase family
H7F25_RS13870	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F25_RS13870	COG1024	Enoyl-CoA hydratase
H7F25_RS13885	COG5577	PFAM Coat F domain
H7F25_RS13895	COG1120	ATPase activity
H7F25_RS13905	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS13910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F25_RS13915	COG0745	RESPONSE REGULATOR receiver
H7F25_RS13920	COG2770	Histidine kinase
H7F25_RS13920	COG2205	protein histidine kinase activity
H7F25_RS13930	COG1309	transcriptional regulator
H7F25_RS13940	COG0114	fumarate hydratase activity
H7F25_RS13950	COG0697	spore germination
H7F25_RS13955	COG0814	amino acid
H7F25_RS13970	COG2197	response regulator
H7F25_RS13975	COG4585	Histidine kinase
H7F25_RS13980	COG4758	membrane
H7F25_RS13990	COG1842	Phage shock protein A
H7F25_RS13995	COG4758	membrane
H7F25_RS14000	COG2096	Adenosyltransferase
H7F25_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS14010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7F25_RS14020	COG2204	response regulator
H7F25_RS14035	COG1454	alcohol dehydrogenase
H7F25_RS14040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7F25_RS14050	COG1120	ATPase activity
H7F25_RS14055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F25_RS14060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F25_RS14070	COG2721	sulfolactate sulfo-lyase activity
H7F25_RS14075	COG0246	Mannitol dehydrogenase
H7F25_RS14080	COG1609	Transcriptional regulator
H7F25_RS14085	COG1904	glucuronate isomerase
H7F25_RS14090	COG2205	protein histidine kinase activity
H7F25_RS14095	COG0745	RESPONSE REGULATOR receiver
H7F25_RS14100	COG1120	ATPase activity
H7F25_RS14105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F25_RS14110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F25_RS14115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F25_RS14120	COG0531	amino acid
H7F25_RS14135	COG1988	membrane-bound metal-dependent
H7F25_RS14140	COG1368	sulfuric ester hydrolase activity
H7F25_RS14145	COG0725	ABC transporter, periplasmic molybdate-binding protein
H7F25_RS14150	COG4149	molybdate abc transporter
H7F25_RS14155	COG0656	L-ascorbic acid biosynthetic process
H7F25_RS14160	COG1940	carbohydrate kinase activity
H7F25_RS14165	COG0025	NhaP-type Na H and K H
H7F25_RS14170	COG2860	membrane
H7F25_RS14175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7F25_RS14180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7F25_RS14185	COG2217	Heavy metal translocating P-type atpase
H7F25_RS14190	COG1121	(ABC) transporter
H7F25_RS14195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7F25_RS14200	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7F25_RS14210	COG3226	Transcriptional regulator
H7F25_RS14215	COG0784	Response regulator, receiver
H7F25_RS14220	COG4191	Histidine kinase
H7F25_RS14225	COG1027	Aspartate ammonia-lyase
H7F25_RS14235	COG2217	Heavy metal translocating P-type atpase
H7F25_RS14240	COG2608	mercury ion transmembrane transporter activity
H7F25_RS14245	COG1937	Protein conserved in bacteria
H7F25_RS14295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7F25_RS14300	COG0557	exoribonuclease II activity
H7F25_RS14305	COG1647	Serine aminopeptidase, S33
H7F25_RS14310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7F25_RS14315	COG2002	toxin-antitoxin pair type II binding
H7F25_RS14320	COG1476	TRANSCRIPTIONal
H7F25_RS14325	COG1396	sequence-specific DNA binding
H7F25_RS14330	COG1396	sequence-specific DNA binding
H7F25_RS14335	COG1733	regulation of RNA biosynthetic process
H7F25_RS14340	COG1174	glycine betaine transport
H7F25_RS14345	COG1732	Glycine betaine
H7F25_RS14350	COG1174	glycine betaine transport
H7F25_RS14355	COG0517	IMP dehydrogenase activity
H7F25_RS14355	COG1125	glycine betaine transport
H7F25_RS14360	COG1510	regulation of RNA biosynthetic process
H7F25_RS14365	COG2095	MarC family integral membrane protein
H7F25_RS14375	COG0456	acetyltransferase
H7F25_RS14395	COG1122	ATPase activity
H7F25_RS14405	COG0148	phosphopyruvate hydratase activity
H7F25_RS14410	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7F25_RS14415	COG0149	triose-phosphate isomerase activity
H7F25_RS14420	COG0126	phosphoglycerate kinase activity
H7F25_RS14425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7F25_RS14430	COG2390	Transcriptional regulator
H7F25_RS14435	COG0833	amino acid
H7F25_RS14440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7F25_RS14445	COG3829	transcription factor binding
H7F25_RS14450	COG2186	Transcriptional regulator
H7F25_RS14455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7F25_RS14465	COG0534	Mate efflux family protein
H7F25_RS14475	COG0444	Belongs to the ABC transporter superfamily
H7F25_RS14480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7F25_RS14485	COG0601	transmembrane transport
H7F25_RS14490	COG0747	negative chemotaxis
H7F25_RS14495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F25_RS14500	COG0110	maltose O-acetyltransferase activity
H7F25_RS14505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7F25_RS14510	COG2244	polysaccharide biosynthetic process
H7F25_RS14515	COG5039	Polysaccharide pyruvyl transferase
H7F25_RS14520	COG1216	Glycosyl transferase, family 2
H7F25_RS14530	COG0438	transferase activity, transferring glycosyl groups
H7F25_RS14535	COG1215	transferase activity, transferring glycosyl groups
H7F25_RS14540	COG0438	transferase activity, transferring glycosyl groups
H7F25_RS14545	COG1086	Polysaccharide biosynthesis protein
H7F25_RS14550	COG0489	protein tyrosine kinase activity
H7F25_RS14555	COG3944	biosynthesis protein
H7F25_RS14560	COG1396	sequence-specific DNA binding
H7F25_RS14570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F25_RS14575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F25_RS14580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7F25_RS14585	COG0726	polysaccharide deacetylase
H7F25_RS14590	COG0488	(ABC) transporter
H7F25_RS14610	COG0601	transmembrane transport
H7F25_RS14615	COG0747	negative chemotaxis
H7F25_RS14620	COG1819	glycosyl
H7F25_RS14635	COG0740	serine-type endopeptidase activity
H7F25_RS14640	COG1611	Belongs to the LOG family
H7F25_RS14645	COG1694	Mazg nucleotide pyrophosphohydrolase
H7F25_RS14650	COG0659	secondary active sulfate transmembrane transporter activity
H7F25_RS14655	COG0288	reversible hydration of carbon dioxide
H7F25_RS14660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7F25_RS14670	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H7F25_RS14675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS14680	COG1481	regulation of sporulation
H7F25_RS14685	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H7F25_RS14690	COG1660	Displays ATPase and GTPase activities
H7F25_RS14695	COG1051	belongs to the nudix hydrolase family
H7F25_RS14700	COG0492	ferredoxin-NADP+ reductase activity
H7F25_RS14705	COG0791	NLP P60 protein
H7F25_RS14705	COG3883	PFAM NLP P60 protein
H7F25_RS14710	COG0457	Tetratricopeptide repeat
H7F25_RS14715	COG0140	phosphoribosyl-ATP diphosphatase activity
H7F25_RS14715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7F25_RS14720	COG0107	imidazoleglycerol-phosphate synthase activity
H7F25_RS14725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7F25_RS14730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7F25_RS14735	COG0131	Imidazoleglycerol-phosphate dehydratase
H7F25_RS14740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7F25_RS14745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7F25_RS14750	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H7F25_RS14755	COG4990	cell redox homeostasis
H7F25_RS14765	COG2910	NAD(P)H-binding
H7F25_RS14770	COG1959	2 iron, 2 sulfur cluster binding
H7F25_RS14775	COG0110	maltose O-acetyltransferase activity
H7F25_RS14780	COG0546	phosphoglycolate phosphatase activity
H7F25_RS14785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H7F25_RS14795	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H7F25_RS14800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7F25_RS14805	COG0363	glucosamine-6-phosphate deaminase activity
H7F25_RS14810	COG2188	Transcriptional regulator
H7F25_RS14815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H7F25_RS14820	COG1950	PFAM Membrane protein of
H7F25_RS14825	COG1983	PspC domain protein
H7F25_RS14830	COG3595	metallopeptidase activity
H7F25_RS14845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7F25_RS14855	COG4897	Protein conserved in bacteria
H7F25_RS14860	COG0574	Belongs to the PEP-utilizing enzyme family
H7F25_RS14860	COG3848	Pyruvate phosphate dikinase
H7F25_RS14865	COG1309	transcriptional regulator
H7F25_RS14870	COG2814	Major facilitator Superfamily
H7F25_RS14880	COG0745	RESPONSE REGULATOR receiver
H7F25_RS14885	COG5002	protein histidine kinase activity
H7F25_RS14890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7F25_RS14895	COG0463	Glycosyl transferase, family 2
H7F25_RS14900	COG1113	amino acid transport
H7F25_RS14905	COG0778	Nitroreductase
H7F25_RS14910	COG1733	regulation of RNA biosynthetic process
H7F25_RS14915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F25_RS14925	COG0793	Belongs to the peptidase S41A family
H7F25_RS14925	COG3409	Peptidoglycan-binding domain 1 protein
H7F25_RS14930	COG0730	response to heat
H7F25_RS14935	COG3883	PFAM NLP P60 protein
H7F25_RS14935	COG0791	NLP P60 protein
H7F25_RS14940	COG2177	Part of the ABC transporter FtsEX involved in
H7F25_RS14945	COG2884	Cell division ATP-binding protein ftsE
H7F25_RS14950	COG2010	Cytochrome c
H7F25_RS14955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F25_RS14975	COG0653	protein targeting
H7F25_RS14980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7F25_RS14985	COG0840	transmembrane signaling receptor activity
H7F25_RS15000	COG1516	flagellar protein fliS
H7F25_RS15005	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H7F25_RS15010	COG1334	flagellar protein FlaG
H7F25_RS15015	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7F25_RS15020	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H7F25_RS15030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7F25_RS15035	COG4786	Flagellar basal body rod
H7F25_RS15035	COG1256	bacterial-type flagellum assembly
H7F25_RS15040	COG3418	PFAM FlgN family protein
H7F25_RS15055	COG1040	competence protein
H7F25_RS15065	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H7F25_RS15070	COG1307	EDD domain protein, DegV family
H7F25_RS15075	COG2197	response regulator
H7F25_RS15080	COG4585	Histidine kinase
H7F25_RS15085	COG1739	Uncharacterized protein family UPF0029
H7F25_RS15090	COG1316	TRANSCRIPTIONal
H7F25_RS15095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7F25_RS15100	COG0438	transferase activity, transferring glycosyl groups
H7F25_RS15105	COG1215	transferase activity, transferring glycosyl groups
H7F25_RS15110	COG3206	protein involved in exopolysaccharide biosynthesis
H7F25_RS15115	COG3307	-O-antigen
H7F25_RS15120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7F25_RS15125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7F25_RS15130	COG0438	transferase activity, transferring glycosyl groups
H7F25_RS15130	COG0297	glycogen (starch) synthase activity
H7F25_RS15135	COG2244	polysaccharide biosynthetic process
H7F25_RS15150	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS15150	COG2247	cell wall binding repeat
H7F25_RS15155	COG2247	cell wall binding repeat
H7F25_RS15155	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS15160	COG2247	cell wall binding repeat
H7F25_RS15160	COG2385	sporulation resulting in formation of a cellular spore
H7F25_RS15170	COG1316	TRANSCRIPTIONal
H7F25_RS15175	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7F25_RS15180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7F25_RS15185	COG1134	teichoic acid transport
H7F25_RS15190	COG1682	transport, permease protein
H7F25_RS15200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F25_RS15210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7F25_RS15215	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H7F25_RS15220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F25_RS15225	COG4193	domain, Protein
H7F25_RS15230	COG1482	cell wall glycoprotein biosynthetic process
H7F25_RS15240	COG1175	transmembrane transport
H7F25_RS15245	COG1653	transport
H7F25_RS15250	COG2201	protein-glutamate methylesterase activity
H7F25_RS15255	COG2972	Histidine kinase
H7F25_RS15265	COG0454	-acetyltransferase
H7F25_RS15270	COG0800	Aldolase
H7F25_RS15275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F25_RS15280	COG1609	Transcriptional regulator
H7F25_RS15285	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H7F25_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS15295	COG0697	spore germination
H7F25_RS15300	COG0814	amino acid
H7F25_RS15315	COG2814	Major facilitator Superfamily
H7F25_RS15320	COG1316	TRANSCRIPTIONal
H7F25_RS15325	COG0561	phosphatase activity
H7F25_RS15330	COG0791	NLP P60 protein
H7F25_RS15340	COG2843	Capsule synthesis protein
H7F25_RS15350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7F25_RS15355	COG0697	spore germination
H7F25_RS15370	COG1609	Transcriptional regulator
H7F25_RS15375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7F25_RS15380	COG1869	D-ribose catabolic process
H7F25_RS15385	COG1129	ABC transporter
H7F25_RS15390	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7F25_RS15395	COG1879	ABC-type sugar transport system periplasmic component
H7F25_RS15400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H7F25_RS15405	COG0583	DNA-binding transcription factor activity
H7F25_RS15410	COG0028	Belongs to the TPP enzyme family
H7F25_RS15415	COG3527	Alpha-acetolactate decarboxylase
H7F25_RS15420	COG1522	sequence-specific DNA binding
H7F25_RS15425	COG2059	Chromate
H7F25_RS15430	COG2059	Chromate
H7F25_RS15435	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H7F25_RS15445	COG4715	Zinc finger, swim domain protein
H7F25_RS15450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7F25_RS15455	COG1366	Belongs to the anti-sigma-factor antagonist family
H7F25_RS15455	COG2202	Pas domain
H7F25_RS15460	COG0561	phosphatase activity
H7F25_RS15475	COG1970	mechanosensitive ion channel activity
H7F25_RS15480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7F25_RS15485	COG0457	Tetratricopeptide repeat
H7F25_RS15490	COG4786	Flagellar basal body rod
H7F25_RS15495	COG4786	Flagellar basal body rod
H7F25_RS15500	COG1077	Cell shape determining protein MreB Mrl
H7F25_RS15505	COG1609	Transcriptional regulator
H7F25_RS15510	COG1846	Transcriptional regulator
H7F25_RS15515	COG2814	Major facilitator Superfamily
H7F25_RS15520	COG0671	phosphoesterase, PA-phosphatase related
H7F25_RS15525	COG0477	Major facilitator Superfamily
H7F25_RS15530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F25_RS15535	COG0765	amino acid transport
H7F25_RS15545	COG0004	ammonium transporteR
H7F25_RS15550	COG0347	Belongs to the P(II) protein family
H7F25_RS15555	COG0739	heme binding
H7F25_RS15560	COG1247	-acetyltransferase
H7F25_RS15600	COG0523	cobalamin synthesis protein
H7F25_RS15605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7F25_RS15610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7F25_RS15615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7F25_RS15620	COG2223	nitrite transmembrane transporter activity
H7F25_RS15625	COG0243	molybdopterin cofactor binding
H7F25_RS15630	COG2304	oxidoreductase activity
H7F25_RS15635	COG2304	oxidoreductase activity
H7F25_RS15640	COG2385	sporulation resulting in formation of a cellular spore
H7F25_RS15645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7F25_RS15655	COG4836	Membrane
H7F25_RS15665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7F25_RS15670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7F25_RS15675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7F25_RS15680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7F25_RS15685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7F25_RS15690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7F25_RS15695	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7F25_RS15700	COG0356	it plays a direct role in the translocation of protons across the membrane
H7F25_RS15710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7F25_RS15715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7F25_RS15720	COG4475	Protein of unknown function (DUF436)
H7F25_RS15725	COG0698	ribose 5-phosphate isomerase
H7F25_RS15730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7F25_RS15735	COG1971	Probably functions as a manganese efflux pump
H7F25_RS15740	COG0009	L-threonylcarbamoyladenylate synthase
H7F25_RS15745	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7F25_RS15760	COG2890	protein-(glutamine-N5) methyltransferase activity
H7F25_RS15765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7F25_RS15770	COG0789	Transcriptional regulator
H7F25_RS15775	COG0679	Auxin Efflux Carrier
H7F25_RS15780	COG0281	malic enzyme
H7F25_RS15785	COG1435	thymidine kinase activity
H7F25_RS15790	COG0254	rRNA binding
H7F25_RS15795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H7F25_RS15800	COG1494	fructose-1,6-bisphosphatase
H7F25_RS15805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7F25_RS15810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7F25_RS15815	COG0191	fructose-bisphosphate aldolase activity
H7F25_RS15820	COG2204	response regulator
H7F25_RS15825	COG4821	SIS domain
H7F25_RS15830	COG0504	CTP synthase activity
H7F25_RS15835	COG3343	RNA polymerase activity
H7F25_RS15845	COG1960	acyl-CoA dehydrogenase activity
H7F25_RS15850	COG1960	acyl-CoA dehydrogenase activity
H7F25_RS15855	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7F25_RS15860	COG0183	Belongs to the thiolase family
H7F25_RS15865	COG0247	lactate metabolic process
H7F25_RS15865	COG2181	nitrate reductase activity
H7F25_RS15870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F25_RS15875	COG4294	response to UV
H7F25_RS15885	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7F25_RS15890	COG1132	(ABC) transporter
H7F25_RS15895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7F25_RS15900	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7F25_RS15905	COG0018	arginyl-trna synthetase
H7F25_RS15910	COG4506	Protein conserved in bacteria
H7F25_RS15920	COG0010	Belongs to the arginase family
H7F25_RS15925	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7F25_RS15930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7F25_RS15940	COG1994	Peptidase M50
H7F25_RS15945	COG1942	4-Oxalocrotonate Tautomerase
H7F25_RS15955	COG3465	dGTPase activity
H7F25_RS15960	COG1078	dGTPase activity
H7F25_RS15965	COG4844	belongs to the
H7F25_RS16015	COG5444	nuclease activity
H7F25_RS16045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7F25_RS16055	COG0280	phosphate acetyltransferase
H7F25_RS16065	COG2814	Major facilitator Superfamily
H7F25_RS16070	COG1522	sequence-specific DNA binding
H7F25_RS16075	COG2814	Major facilitator Superfamily
H7F25_RS16080	COG0077	Prephenate dehydratase
H7F25_RS16090	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS16095	COG0151	Belongs to the GarS family
H7F25_RS16100	COG0436	Aminotransferase
H7F25_RS16105	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS16110	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H7F25_RS16115	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7F25_RS16120	COG1088	dTDP-glucose 4,6-dehydratase activity
H7F25_RS16125	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7F25_RS16130	COG3980	spore coat polysaccharide biosynthesis protein
H7F25_RS16135	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
H7F25_RS16140	COG2089	acid synthase
H7F25_RS16145	COG0456	acetyltransferase
H7F25_RS16150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7F25_RS16155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H7F25_RS16160	COG0463	Glycosyl transferase, family 2
H7F25_RS16180	COG2363	Small membrane protein
H7F25_RS16185	COG2233	PERMEase
H7F25_RS16195	COG1012	belongs to the aldehyde dehydrogenase family
H7F25_RS16200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7F25_RS16205	COG1216	Glycosyl transferase, family 2
H7F25_RS16215	COG0351	phosphomethylpyrimidine kinase
H7F25_RS16235	COG3964	amidohydrolase
H7F25_RS16240	COG1621	beta-fructofuranosidase activity
H7F25_RS16245	COG1263	PTS System
H7F25_RS16245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS16250	COG3711	transcriptional antiterminator
H7F25_RS16260	COG1404	Belongs to the peptidase S8 family
H7F25_RS16265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F25_RS16270	COG0778	Nitroreductase
H7F25_RS16275	COG0772	Belongs to the SEDS family
H7F25_RS16285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7F25_RS16290	COG1845	cytochrome c oxidase, subunit III
H7F25_RS16295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7F25_RS16300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7F25_RS16310	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H7F25_RS16315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7F25_RS16320	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7F25_RS16335	COG2246	polysaccharide biosynthetic process
H7F25_RS16355	COG3162	membrane
H7F25_RS16360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7F25_RS16370	COG0352	thiamine-phosphate diphosphorylase activity
H7F25_RS16375	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H7F25_RS16380	COG0583	DNA-binding transcription factor activity
H7F25_RS16385	COG1380	Effector of murein hydrolase LrgA
H7F25_RS16390	COG1346	cytolysis
H7F25_RS16395	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7F25_RS16400	COG0346	lactoylglutathione lyase activity
H7F25_RS16410	COG0765	amino acid transport
H7F25_RS16415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7F25_RS16420	COG0457	Tetratricopeptide repeat
H7F25_RS16430	COG2357	RelA SpoT domain protein
H7F25_RS16435	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7F25_RS16440	COG1129	ABC transporter
H7F25_RS16450	COG3420	alginic acid biosynthetic process
H7F25_RS16455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F25_RS16465	COG1486	melibiose metabolic process
H7F25_RS16470	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7F25_RS16475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F25_RS16480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F25_RS16485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS16485	COG3711	transcriptional antiterminator
H7F25_RS16500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7F25_RS16515	COG1595	DNA-templated transcription, initiation
H7F25_RS16525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7F25_RS16530	COG4988	ABC transporter
H7F25_RS16535	COG1294	oxidase, subunit
H7F25_RS16540	COG1271	oxidase subunit
H7F25_RS16560	COG4509	Sortase family
H7F25_RS16585	COG5386	Cell surface protein
H7F25_RS16590	COG5386	Cell surface protein
H7F25_RS16595	COG1733	regulation of RNA biosynthetic process
H7F25_RS16600	COG2514	catechol 2,3-dioxygenase activity
H7F25_RS16605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F25_RS16605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7F25_RS16610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F25_RS16610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7F25_RS16620	COG0726	polysaccharide deacetylase
H7F25_RS16625	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7F25_RS16630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F25_RS16635	COG2723	6-phospho-beta-galactosidase activity
H7F25_RS16640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7F25_RS16645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS16645	COG3711	transcriptional antiterminator
H7F25_RS16670	COG1757	Na H antiporter
H7F25_RS16675	COG1027	Aspartate ammonia-lyase
H7F25_RS16680	COG0252	asparaginase activity
H7F25_RS16685	COG1396	sequence-specific DNA binding
H7F25_RS16710	COG4842	Belongs to the WXG100 family
H7F25_RS16715	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7F25_RS16730	COG1737	Transcriptional regulator
H7F25_RS16735	COG2084	Dehydrogenase
H7F25_RS16745	COG2610	gluconate transmembrane transporter activity
H7F25_RS16750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7F25_RS16760	COG2723	6-phospho-beta-galactosidase activity
H7F25_RS16765	COG2190	(PTS) system
H7F25_RS16765	COG1263	PTS System
H7F25_RS16765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS16770	COG3711	transcriptional antiterminator
H7F25_RS16775	COG3878	Protein conserved in bacteria
H7F25_RS16785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H7F25_RS16790	COG1122	ATPase activity
H7F25_RS16795	COG4721	ABC-type cobalt transport system, permease component
H7F25_RS16800	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H7F25_RS16835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H7F25_RS16840	COG0778	Nitroreductase
H7F25_RS16845	COG1846	Transcriptional regulator
H7F25_RS16850	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7F25_RS16855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7F25_RS16860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7F25_RS16865	COG2390	Transcriptional regulator
H7F25_RS16875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H7F25_RS16875	COG2755	lipolytic protein G-D-S-L family
H7F25_RS16895	COG0561	phosphatase activity
H7F25_RS16900	COG0789	Transcriptional regulator
H7F25_RS16905	COG0673	inositol 2-dehydrogenase activity
H7F25_RS16910	COG0840	transmembrane signaling receptor activity
H7F25_RS16915	COG1113	amino acid transport
H7F25_RS16920	COG4335	DNA alkylation repair
H7F25_RS16930	COG1070	Carbohydrate kinase
H7F25_RS16935	COG1737	Transcriptional regulator
H7F25_RS16965	COG0583	DNA-binding transcription factor activity
H7F25_RS16970	COG1609	Transcriptional regulator
H7F25_RS16975	COG2182	Extracellular solute-binding protein
H7F25_RS16980	COG1175	transmembrane transport
H7F25_RS16985	COG3833	ABC-type maltose transport systems, permease component
H7F25_RS16995	COG1874	Beta-galactosidase
H7F25_RS17000	COG2851	Citrate transporter
H7F25_RS17010	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H7F25_RS17015	COG1131	(ABC) transporter
H7F25_RS17020	COG2824	Alkylphosphonate utilization operon protein PhnA
H7F25_RS17025	COG1929	Belongs to the glycerate kinase type-1 family
H7F25_RS17030	COG2610	gluconate transmembrane transporter activity
H7F25_RS17035	COG3835	regulator
H7F25_RS17040	COG1309	transcriptional regulator
H7F25_RS17045	COG2814	Major facilitator Superfamily
H7F25_RS17055	COG1136	(ABC) transporter
H7F25_RS17055	COG0577	efflux transmembrane transporter activity
H7F25_RS17065	COG0457	Tetratricopeptide repeat
H7F25_RS17070	COG3711	transcriptional antiterminator
H7F25_RS17075	COG2723	6-phospho-beta-galactosidase activity
H7F25_RS17080	COG2190	(PTS) system
H7F25_RS17080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS17080	COG1263	PTS System
H7F25_RS17115	COG1113	amino acid transport
H7F25_RS17120	COG1609	Transcriptional regulator
H7F25_RS17125	COG2814	Major facilitator Superfamily
H7F25_RS17135	COG2814	Major facilitator Superfamily
H7F25_RS17155	COG5444	nuclease activity
H7F25_RS17165	COG2723	6-phospho-beta-galactosidase activity
H7F25_RS17175	COG2188	Transcriptional regulator
H7F25_RS17185	COG0384	phenazine biosynthesis protein PhzF
H7F25_RS17190	COG0583	DNA-binding transcription factor activity
H7F25_RS17215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7F25_RS17225	COG2814	Major facilitator Superfamily
H7F25_RS17230	COG0640	Transcriptional regulator
H7F25_RS17250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7F25_RS17260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H7F25_RS17270	COG4720	Psort location CytoplasmicMembrane, score
H7F25_RS17290	COG0456	acetyltransferase
H7F25_RS17295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7F25_RS17300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7F25_RS17305	COG4853	Protein conserved in bacteria
H7F25_RS17310	COG4863	YycH protein
H7F25_RS17315	COG5002	protein histidine kinase activity
H7F25_RS17320	COG0745	RESPONSE REGULATOR receiver
H7F25_RS17345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7F25_RS17355	COG2311	Membrane
H7F25_RS17360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7F25_RS17365	COG0346	lactoylglutathione lyase activity
H7F25_RS17370	COG0305	Participates in initiation and elongation during chromosome replication
H7F25_RS17395	COG2819	hydrolase of the alpha beta superfamily
H7F25_RS17400	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS17405	COG1169	isochorismate synthase
H7F25_RS17410	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7F25_RS17415	COG1535	isochorismatase
H7F25_RS17415	COG3433	isochorismatase activity
H7F25_RS17420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7F25_RS17425	COG3251	PFAM MbtH domain protein
H7F25_RS17430	COG2207	Transcriptional regulator
H7F25_RS17430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F25_RS17435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7F25_RS17440	COG2819	hydrolase of the alpha beta superfamily
H7F25_RS17445	COG3093	addiction module antidote protein HigA
H7F25_RS17450	COG2807	transmembrane transport
H7F25_RS17455	COG0359	binds to the 23S rRNA
H7F25_RS17460	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H7F25_RS17465	COG4241	membrane
H7F25_RS17470	COG1227	inorganic diphosphatase activity
H7F25_RS17480	COG1595	DNA-templated transcription, initiation
H7F25_RS17490	COG0753	catalase activity
H7F25_RS17495	COG0655	NAD(P)H dehydrogenase (quinone) activity
H7F25_RS17500	COG0400	carboxylic ester hydrolase activity
H7F25_RS17505	COG0346	lactoylglutathione lyase activity
H7F25_RS17510	COG1174	glycine betaine transport
H7F25_RS17515	COG0517	IMP dehydrogenase activity
H7F25_RS17515	COG1125	glycine betaine transport
H7F25_RS17520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7F25_RS17525	COG0629	single-stranded DNA binding
H7F25_RS17530	COG0360	Binds together with S18 to 16S ribosomal RNA
H7F25_RS17535	COG0012	GTP binding
H7F25_RS17540	COG4481	Protein conserved in bacteria
H7F25_RS17555	COG3949	Membrane
H7F25_RS17565	COG1475	DNA binding
H7F25_RS17570	COG1192	Involved in chromosome partitioning
H7F25_RS17580	COG1475	DNA binding
H7F25_RS17585	COG0357	Ribosomal RNA small subunit methyltransferase G
H7F25_RS17590	COG0445	tRNA wobble uridine modification
H7F25_RS17595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7F25_RS17600	COG1847	R3H domain protein
H7F25_RS17605	COG0706	membrane insertase activity
H7F25_RS17610	COG0594	ribonuclease P activity
H7F25_RS17615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7F25_RS17620	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7F25_RS17625	COG0592	DNA-directed DNA polymerase activity
H7F25_RS17630	COG2501	S4 domain
H7F25_RS17635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7F25_RS17645	COG0187	DNA topoisomerase II activity
H7F25_RS17650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H7F25_RS17685	COG0517	IMP dehydrogenase activity
H7F25_RS17685	COG0516	GMP reductase activity
H7F25_RS17690	COG1686	Belongs to the peptidase S11 family
H7F25_RS17695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7F25_RS17700	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H7F25_RS17705	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H7F25_RS17710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7F25_RS17715	COG0840	transmembrane signaling receptor activity
H7F25_RS17725	COG1428	Deoxynucleoside kinase
H7F25_RS17730	COG1428	Deoxynucleoside kinase
H7F25_RS17735	COG1388	LysM domain
H7F25_RS17735	COG3858	chitin binding
H7F25_RS17740	COG1335	isochorismatase
H7F25_RS17745	COG0590	tRNA wobble adenosine to inosine editing
H7F25_RS17755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7F25_RS17760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7F25_RS17765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7F25_RS17810	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
H7F25_RS17815	COG3853	Toxic anion resistance protein (TelA)
H7F25_RS17820	COG1982	Orn Lys Arg decarboxylase major
H7F25_RS17825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7F25_RS17830	COG3870	Protein conserved in bacteria
H7F25_RS17835	COG1728	Protein conserved in bacteria
H7F25_RS17840	COG0470	DNA polymerase III
H7F25_RS17845	COG1774	PSP1 C-terminal conserved region
H7F25_RS17850	COG4467	Involved in initiation control of chromosome replication
H7F25_RS17855	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7F25_RS17860	COG2827	Endonuclease containing a URI domain
H7F25_RS17865	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7F25_RS17870	COG2002	toxin-antitoxin pair type II binding
H7F25_RS17875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F25_RS17875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7F25_RS17880	COG0084	hydrolase, TatD family'
H7F25_RS17885	COG3584	3D domain protein
H7F25_RS17885	COG3583	domain protein
H7F25_RS17890	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H7F25_RS17895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7F25_RS17905	COG4466	Protein conserved in bacteria
H7F25_RS17915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7F25_RS17920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7F25_RS17925	COG0251	oxidation-reduction process
H7F25_RS17930	COG2088	sporulation resulting in formation of a cellular spore
H7F25_RS17940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7F25_RS17945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7F25_RS17950	COG0193	aminoacyl-tRNA hydrolase activity
H7F25_RS17960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7F25_RS17965	COG2002	toxin-antitoxin pair type II binding
H7F25_RS17970	COG2244	polysaccharide biosynthetic process
H7F25_RS17975	COG3956	TIGRFAM MazG family protein
H7F25_RS17980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H7F25_RS17995	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7F25_RS18000	COG1098	S1 RNA binding domain
H7F25_RS18015	COG2208	phosphoserine phosphatase activity
H7F25_RS18020	COG2304	oxidoreductase activity
H7F25_RS18025	COG0515	serine threonine protein kinase
H7F25_RS18030	COG0037	tRNA processing
H7F25_RS18035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7F25_RS18040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7F25_RS18045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H7F25_RS18050	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7F25_RS18055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7F25_RS18060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7F25_RS18065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7F25_RS18070	COG0512	Glutamine amidotransferase of anthranilate synthase
H7F25_RS18075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7F25_RS18080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7F25_RS18085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7F25_RS18090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7F25_RS18095	COG1396	sequence-specific DNA binding
H7F25_RS18100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7F25_RS18105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7F25_RS18185	COG4463	regulation of RNA biosynthetic process
H7F25_RS18190	COG3880	PFAM UvrB UvrC protein
H7F25_RS18195	COG3869	Catalyzes the specific phosphorylation of arginine residues in
H7F25_RS18200	COG0542	response to heat
H7F25_RS18205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7F25_RS18210	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H7F25_RS18215	COG4956	integral membrane protein (PIN domain superfamily)
H7F25_RS18220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7F25_RS18225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H7F25_RS18230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7F25_RS18235	COG1045	serine acetyltransferase
H7F25_RS18240	COG0215	cysteine-tRNA ligase activity
H7F25_RS18245	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H7F25_RS18250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7F25_RS18255	COG3688	RNA-binding protein containing a PIN domain
H7F25_RS18260	COG1595	DNA-templated transcription, initiation
H7F25_RS18265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7F25_RS18270	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7F25_RS18275	COG0250	Participates in transcription elongation, termination and antitermination
H7F25_RS18285	COG0081	regulation of translation
H7F25_RS18290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7F25_RS18295	COG0222	ribosome binding
H7F25_RS18300	COG2813	Specifically methylates the guanine in position
H7F25_RS18305	COG0085	RNA polymerase activity
H7F25_RS18310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7F25_RS18315	COG1358	cellular component organization or biogenesis
H7F25_RS18320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7F25_RS18325	COG0049	tRNA binding
H7F25_RS18330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7F25_RS18335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7F25_RS18340	COG0596	Alpha beta hydrolase
H7F25_RS18350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7F25_RS18355	COG0088	Forms part of the polypeptide exit tunnel
H7F25_RS18360	COG0089	rRNA binding
H7F25_RS18365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7F25_RS18370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7F25_RS18375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7F25_RS18380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7F25_RS18390	COG0255	Belongs to the universal ribosomal protein uL29 family
H7F25_RS18395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7F25_RS18400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7F25_RS18405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7F25_RS18410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7F25_RS18415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7F25_RS18420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7F25_RS18425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7F25_RS18430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7F25_RS18435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7F25_RS18440	COG1841	ribosomal large subunit assembly
H7F25_RS18445	COG0200	Binds to the 23S rRNA
H7F25_RS18450	COG0201	protein transport
H7F25_RS18455	COG0563	adenylate kinase activity
H7F25_RS18460	COG0024	Methionine aminopeptidase
H7F25_RS18465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7F25_RS18470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7F25_RS18475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7F25_RS18480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7F25_RS18485	COG0202	RNA polymerase activity
H7F25_RS18490	COG0203	ribosomal protein L17
H7F25_RS18495	COG1122	ATPase activity
H7F25_RS18500	COG1122	ATPase activity
H7F25_RS18505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H7F25_RS18510	COG0101	tRNA pseudouridine synthase activity
H7F25_RS18515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7F25_RS18520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7F25_RS18525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7F25_RS18550	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7F25_RS18555	COG0489	protein tyrosine kinase activity
H7F25_RS18565	COG2194	sulfuric ester hydrolase activity
H7F25_RS18570	COG0726	polysaccharide deacetylase
H7F25_RS18600	COG0659	secondary active sulfate transmembrane transporter activity
H7F25_RS18605	COG0385	Bile acid
H7F25_RS18610	COG3876	Protein conserved in bacteria
H7F25_RS18615	COG1472	Belongs to the glycosyl hydrolase 3 family
H7F25_RS18620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7F25_RS18625	COG1263	PTS System
H7F25_RS18625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS18630	COG1737	Transcriptional regulator
H7F25_RS18635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H7F25_RS18670	COG1595	DNA-templated transcription, initiation
H7F25_RS18675	COG5662	AntiSigma factor
H7F25_RS18680	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H7F25_RS18685	COG4856	YbbR-like protein
H7F25_RS18690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7F25_RS18695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7F25_RS18715	COG1131	(ABC) transporter
H7F25_RS18730	COG1131	(ABC) transporter
H7F25_RS18740	COG1413	lyase activity
H7F25_RS18750	COG2311	Membrane
H7F25_RS18770	COG1113	amino acid transport
H7F25_RS18775	COG0584	glycerophosphoryl diester phosphodiesterase
H7F25_RS18780	COG2271	Major facilitator Superfamily
H7F25_RS18790	COG1331	Highly conserved protein containing a thioredoxin domain
H7F25_RS18795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7F25_RS18815	COG1937	Protein conserved in bacteria
H7F25_RS18820	COG2210	Belongs to the sulfur carrier protein TusA family
H7F25_RS18830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F25_RS18830	COG0425	Belongs to the sulfur carrier protein TusA family
H7F25_RS18835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7F25_RS18835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7F25_RS18840	COG0425	Belongs to the sulfur carrier protein TusA family
H7F25_RS18845	COG0730	response to heat
H7F25_RS18855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7F25_RS18860	COG2814	Major facilitator Superfamily
H7F25_RS18870	COG1846	Transcriptional regulator
H7F25_RS18880	COG1683	Conserved Protein
H7F25_RS18890	COG0656	L-ascorbic acid biosynthetic process
H7F25_RS18895	COG1054	Belongs to the UPF0176 family
H7F25_RS18900	COG0531	amino acid
H7F25_RS18910	COG3711	transcriptional antiterminator
H7F25_RS18915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7F25_RS18915	COG1263	PTS System
H7F25_RS18915	COG2190	(PTS) system
H7F25_RS18920	COG2723	6-phospho-beta-galactosidase activity
H7F25_RS18940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7F25_RS18940	COG3711	transcriptional antiterminator
H7F25_RS18945	COG1940	carbohydrate kinase activity
H7F25_RS18950	COG0383	alpha-mannosidase activity
H7F25_RS18955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F25_RS18960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7F25_RS18970	COG1404	Belongs to the peptidase S8 family
H7F25_RS18985	COG0833	amino acid
H7F25_RS18990	COG2040	homocysteine
H7F25_RS18995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7F25_RS19000	COG1695	Transcriptional regulator
H7F25_RS19015	COG2814	Major facilitator Superfamily
H7F25_RS19020	COG0456	acetyltransferase
H7F25_RS19035	COG1404	Belongs to the peptidase S8 family
H7F25_RS19045	COG1309	transcriptional regulator
H7F25_RS19050	COG1917	Cupin 2, conserved barrel domain protein
H7F25_RS19055	COG1063	alcohol dehydrogenase
H7F25_RS19060	COG1846	Transcriptional regulator
H7F25_RS19065	COG0318	PFAM AMP-dependent synthetase and ligase
H7F25_RS19070	COG0531	amino acid
H7F25_RS19080	COG0596	Alpha beta hydrolase
H7F25_RS19085	COG1115	amino acid carrier protein
H7F25_RS19090	COG2066	Belongs to the glutaminase family
H7F25_RS19095	COG4191	Histidine kinase
H7F25_RS19100	COG0784	Response regulator, receiver
H7F25_RS19105	COG3012	SEC-C Motif Domain Protein
H7F25_RS19105	COG1405	negative regulation of cell septum assembly
H7F25_RS19115	COG2197	response regulator
H7F25_RS19120	COG4585	Histidine kinase
H7F25_RS19130	COG0667	Aldo Keto reductase
H7F25_RS19135	COG3290	protein histidine kinase activity
H7F25_RS19140	COG3279	Response regulator of the LytR AlgR family
H7F25_RS19145	COG4555	ABC transporter
H7F25_RS19150	COG1668	transmembrane transport
H7F25_RS19165	COG3773	Cell wall hydrolase
H7F25_RS19170	COG1028	Short-chain dehydrogenase reductase Sdr
H7F25_RS19180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7F25_RS19185	COG2310	stress, protein
H7F25_RS19190	COG2310	stress, protein
H7F25_RS19195	COG2310	stress, protein
H7F25_RS19200	COG0861	Integral membrane protein TerC family
H7F25_RS19230	COG3853	Toxic anion resistance protein (TelA)
H7F25_RS19235	COG4175	Glycine betaine
H7F25_RS19235	COG0517	IMP dehydrogenase activity
H7F25_RS19240	COG4176	ABC-type proline glycine betaine transport system permease component