locus-tag class description BHV55_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BHV55_RS00015 ENOG410848D S4 domain protein YaaA BHV55_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BHV55_RS00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BHV55_RS00100 ENOG4105ZMH deoxynucleoside kinase BHV55_RS00110 ENOG4105GTG Isochorismatase BHV55_RS00115 ENOG4108Z6B deaminase BHV55_RS00125 ENOG4105C6E dna polymerase iii BHV55_RS00145 ENOG41067KS pro-sigma K processing BHV55_RS00180 ENOG4105CXN decarboxylase BHV55_RS00190 ENOG4105FA2 dna polymerase iii BHV55_RS00195 ENOG4105MA4 psp1 domain protein BHV55_RS00205 ENOG41060K3 Methyltransferase BHV55_RS00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BHV55_RS00220 ENOG4105KRN Transcriptional regulator, abrb family BHV55_RS00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BHV55_RS00230 ENOG4105F8V Hydrolase, tatD family BHV55_RS00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BHV55_RS00245 ENOG4105XFA sporulation peptidase YabG BHV55_RS00250 ENOG4105W42 Veg protein BHV55_RS00265 ENOG4105DFT pur operon repressor BHV55_RS00270 ENOG4105KME endoribonuclease L-psp BHV55_RS00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BHV55_RS00300 ENOG4108JA2 transcriptioN-repair coupling factor BHV55_RS00305 ENOG4108M14 stage v sporulation protein t BHV55_RS00315 ENOG4108IY2 MazG family BHV55_RS00320 ENOG41082I2 s4 domain protein BHV55_RS00325 ENOG4105VYY sporulation protein yabp BHV55_RS00340 ENOG41060GV RNA binding s1 domain protein BHV55_RS00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BHV55_RS00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase BHV55_RS00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BHV55_RS00385 ENOG4105C6T cysteine synthase BHV55_RS00390 ENOG4105CRQ synthase (Component I) BHV55_RS00395 ENOG4105DDQ anthranilate synthase BHV55_RS00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BHV55_RS00405 ENOG4105EEI dihydropteroate synthase BHV55_RS00410 ENOG4105KRF dihydroneopterin aldolase BHV55_RS00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BHV55_RS00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BHV55_RS00515 ENOG4108Z0C Uvrb UvrC protein BHV55_RS00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BHV55_RS00540 ENOG4105CTP PilT protein domain protein BHV55_RS00545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BHV55_RS00560 ENOG4105D7W serine acetyltransferase BHV55_RS00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 BHV55_RS00580 ENOG4105M0M Tetracycline resistance protein BHV55_RS00585 ENOG4105QIV RNA polymerase BHV55_RS00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BHV55_RS00625 ENOG4107Y49 methyltransferase BHV55_RS00640 ENOG4105XPM ribosomal protein BHV55_RS00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BHV55_RS00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BHV55_RS00815 ENOG4108JJB ABC transporter BHV55_RS00820 ENOG4108JJB ABC transporter BHV55_RS00825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BHV55_RS00830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BHV55_RS00855 ENOG4105D1F ATP-binding protein BHV55_RS00870 ENOG4108NMV polysaccharide deacetylase BHV55_RS00950 ENOG4105C8B TIGR00159 family BHV55_RS00955 ENOG4107U5W ybbr family BHV55_RS00970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BHV55_RS01005 ENOG4108PSK reductase BHV55_RS01010 ENOG4108UMI ABC transporter, permease BHV55_RS01015 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BHV55_RS01020 ENOG4105D01 (LipO)protein BHV55_RS01025 ENOG4105CB2 alcohol dehydrogenase BHV55_RS01035 ENOG4105IQ5 FAD linked oxidase domain protein BHV55_RS01050 ENOG4105C2C drug resistance transporter, Bcr CflA BHV55_RS01065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BHV55_RS01070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BHV55_RS01075 ENOG4105C3U ABC transporter BHV55_RS01080 ENOG4108JQ7 (ABC) transporter BHV55_RS01110 ENOG4108J59 Extracellular solute-binding protein, family 5 BHV55_RS01115 ENOG4108J59 Extracellular solute-binding protein, family 5 BHV55_RS01135 ENOG4105E0C molybdate abc transporter BHV55_RS01140 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BHV55_RS01145 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BHV55_RS01155 ENOG4105EGI Transcriptional regulator BHV55_RS01175 ENOG4105F6E Acyl-transferase BHV55_RS01195 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BHV55_RS01210 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BHV55_RS01230 ENOG4105C5H ABC transporter BHV55_RS01240 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BHV55_RS01250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BHV55_RS01255 ENOG4105C3U ABC transporter BHV55_RS01260 ENOG4108JQ7 (ABC) transporter BHV55_RS01265 ENOG410667J hydrolase BHV55_RS01295 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BHV55_RS01300 ENOG4105ERH Fumarylacetoacetate hydrolase BHV55_RS01310 ENOG4105CUB amino acid BHV55_RS01315 ENOG4108SC4 )-transporter BHV55_RS01320 ENOG4105CPF Cell wall formation (By similarity) BHV55_RS01325 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BHV55_RS01350 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BHV55_RS01355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BHV55_RS01365 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BHV55_RS01470 ENOG4105K8N protein family UPF0079, ATPase BHV55_RS01475 ENOG41072GX Peptidase M22 Glycoprotease BHV55_RS01480 ENOG410801F ribosomal-protein-alanine acetyltransferase BHV55_RS01485 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BHV55_RS01490 ENOG4105C5H ABC transporter BHV55_RS01505 ENOG4108TYN CAAX amino terminal protease family protein BHV55_RS01525 ENOG4105C7N Xanthine uracil vitamin C permease BHV55_RS01535 ENOG4105BZU Histidine kinase BHV55_RS01560 ENOG4107ZXU DSBA oxidoreductase BHV55_RS01605 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHV55_RS01640 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BHV55_RS01670 ENOG4105SX7 Transporter BHV55_RS01700 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BHV55_RS01705 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BHV55_RS01710 ENOG4105C83 adenylosuccinate lyase BHV55_RS01720 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BHV55_RS01745 ENOG4108V3E phosphoribosylglycinamide formyltransferase BHV55_RS01755 ENOG4105C12 Phosphoribosylglycinamide synthetase BHV55_RS01780 ENOG4105C4R Atp-dependent dna helicase BHV55_RS01785 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BHV55_RS01805 ENOG4108W2Y isochorismatase BHV55_RS01810 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BHV55_RS01815 ENOG4108UMI ABC transporter, permease BHV55_RS01820 ENOG4105D01 (LipO)protein BHV55_RS01840 ENOG410834F Transcriptional regulator BHV55_RS01845 ENOG4107I77 yiaA/B two helix domain BHV55_RS01865 ENOG4105CBD Diacylglycerol kinase BHV55_RS01870 ENOG4105D7V transposase BHV55_RS01875 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BHV55_RS01880 ENOG4108JPW Aminotransferase BHV55_RS01890 ENOG4105C26 Dehydrogenase BHV55_RS01895 ENOG4105KPY Small multidrug resistance protein BHV55_RS01925 ENOG4105D9N nucleoside BHV55_RS01930 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BHV55_RS01985 ENOG4108W15 Protein of unknown function (DUF1456) BHV55_RS02000 ENOG4105DTQ mandelate racemase muconate lactonizing BHV55_RS02010 ENOG4105DFD Na H antiporter BHV55_RS02030 ENOG4105D3R alkyl hydroperoxide reductase BHV55_RS02050 ENOG4105EHG Permease protein BHV55_RS02055 ENOG4105DQ5 transport system permease protein BHV55_RS02060 ENOG4108V5C ABC transporter BHV55_RS02080 ENOG4106UIA BHV55_RS02085 ENOG4106UIA BHV55_RS02100 ENOG4105BZU Histidine kinase BHV55_RS02120 ENOG410756H nucleotidyltransferase BHV55_RS02125 ENOG4105D2S major facilitator superfamily BHV55_RS02140 ENOG4105E5Q amino acid AbC transporter BHV55_RS02145 ENOG4105EAB amino acid AbC transporter BHV55_RS02155 ENOG4105C8Q Methyl-accepting chemotaxis BHV55_RS02170 ENOG4105DBV ornithine carbamoyltransferase BHV55_RS02180 ENOG4105C5B carbamate kinase BHV55_RS02185 ENOG4108W63 CRP FNR family transcriptional regulator BHV55_RS02205 ENOG4105CI1 PTS System BHV55_RS02245 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BHV55_RS02260 ENOG4108IUX (ABC) transporter BHV55_RS02265 ENOG4105RHA ABC transporter, permease BHV55_RS02285 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BHV55_RS02305 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BHV55_RS02345 ENOG41062JF Transcriptional regulator BHV55_RS02360 ENOG4105DEU major facilitator superfamily BHV55_RS02375 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BHV55_RS02390 ENOG4108N0M stress protein BHV55_RS02395 ENOG4106FN3 tellurium resistance protein BHV55_RS02400 ENOG4106FN3 tellurium resistance protein BHV55_RS02405 ENOG4107TS3 membrane protein, TerC BHV55_RS02410 ENOG4108TTB tellurium resistance protein BHV55_RS02430 ENOG4105KJF protein tyrosine phosphatase BHV55_RS02440 ENOG4107U9T Pfam:Ribonuclease_BN BHV55_RS02445 ENOG4105C59 p-type ATPase BHV55_RS02450 ENOG4108IPJ Membrane BHV55_RS02470 ENOG4107ZTW SNARE associated Golgi BHV55_RS02485 ENOG410606W general stress protein BHV55_RS02490 ENOG4105UPD Calcium Proton BHV55_RS02525 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BHV55_RS02530 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BHV55_RS02540 ENOG4108JUB Transcriptional regulator BHV55_RS02550 ENOG4108IQI permease BHV55_RS02590 ENOG4108A04 Beta-lactamase BHV55_RS02605 ENOG4105CKK Glycosyl transferase, family 2 BHV55_RS02610 ENOG4107QQG Dehydrogenase BHV55_RS02615 ENOG4105C3I Nad-dependent epimerase dehydratase BHV55_RS02635 ENOG4105F1A Pyruvate formate-lyase BHV55_RS02640 ENOG4108QBV Monogalactosyldiacylglycerol synthase BHV55_RS02655 ENOG4105CI2 imidazolone-5-propionate hydrolase BHV55_RS02660 ENOG4105ECP epimerase BHV55_RS02690 ENOG41067AE Membrane-bound metal-dependent hydrolase BHV55_RS02695 ENOG4105CEN a g-specific adenine glycosylase BHV55_RS02700 ENOG4106BXE BHV55_RS02720 ENOG4105BZ1 (ABC) transporter BHV55_RS02725 ENOG4107NBY Membrane BHV55_RS02730 ENOG4105CBC glutamate synthase BHV55_RS02740 ENOG4108IUW ABC transporter BHV55_RS02760 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BHV55_RS02765 ENOG4105G5W regulator Fur family BHV55_RS02885 ENOG4108JQC penicillin-binding protein 1A BHV55_RS02890 ENOG4108R9S DSBA oxidoreductase BHV55_RS02900 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BHV55_RS02910 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BHV55_RS02920 ENOG4105CYN Serine protein kinase BHV55_RS02940 ENOG4105C94 Transporter BHV55_RS02955 ENOG4105DZ6 Band 7 protein BHV55_RS02965 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BHV55_RS02970 ENOG4108V9W transcriptional regulatory protein BHV55_RS02975 ENOG4105D4T Citrate transporter BHV55_RS03000 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BHV55_RS03005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BHV55_RS03010 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BHV55_RS03015 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BHV55_RS03020 ENOG4105BZ7 extracellular solute-binding protein family 1 BHV55_RS03025 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BHV55_RS03030 ENOG4108STX response regulator BHV55_RS03035 ENOG41062D9 Histidine kinase BHV55_RS03060 ENOG4108MRH transcriptional regulatory protein BHV55_RS03070 ENOG4105C6K Malic enzyme BHV55_RS03080 ENOG4108UZ3 Transporter BHV55_RS03085 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BHV55_RS03095 ENOG4105BZU Histidine kinase BHV55_RS03100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS03110 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BHV55_RS03115 ENOG4108JB9 formate dehydrogenase BHV55_RS03135 ENOG4105CUB amino acid BHV55_RS03150 ENOG4105C59 p-type ATPase BHV55_RS03155 ENOG4105DAP Nicotinate phosphoribosyltransferase BHV55_RS03190 ENOG41073R8 VanW family BHV55_RS03195 ENOG4108KGH TRANSCRIPTIONal BHV55_RS03200 ENOG4105D9N nucleoside BHV55_RS03205 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BHV55_RS03210 ENOG4105C37 (CBS) domain BHV55_RS03215 ENOG4108IJ0 Aspartate ammonia-lyase BHV55_RS03220 ENOG4105DAA L-lactate BHV55_RS03235 ENOG4105DUX Transporter BHV55_RS03240 ENOG4108MES Periplasmic binding protein BHV55_RS03245 ENOG4105DQ5 transport system permease protein BHV55_RS03250 ENOG4108IHU transport system permease protein BHV55_RS03255 ENOG4105E0A ABC, transporter BHV55_RS03260 ENOG4105DMQ Methyltransferase BHV55_RS03265 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BHV55_RS03270 ENOG4105EXW epimerase dehydratase BHV55_RS03275 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BHV55_RS03285 ENOG4107T89 von Willebrand factor, type A BHV55_RS03290 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BHV55_RS03295 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BHV55_RS03305 ENOG4105BZU Histidine kinase BHV55_RS03310 ENOG4105D5Q Arginine ornithine antiporter BHV55_RS03315 ENOG4107414 GntR family transcriptional regulator BHV55_RS03320 ENOG4105C5Y PTS System BHV55_RS03325 ENOG4105CG3 alpha amylase, catalytic region BHV55_RS03340 ENOG4105E1K spore germination protein BHV55_RS03345 ENOG4105CRN Aminoglycoside phosphotransferase BHV55_RS03350 ENOG4105BZG amino acid carrier protein BHV55_RS03355 ENOG4105CDA abc transporter atp-binding protein BHV55_RS03360 ENOG4105CT1 (ABC) transporter BHV55_RS03365 ENOG4105EAD ABC transporter BHV55_RS03370 ENOG4105DRP amino acid AbC transporter BHV55_RS03375 ENOG4108IQI permease BHV55_RS03390 ENOG4105GFR rna polymerase sigma factor BHV55_RS03400 ENOG4105D29 Helix-turn-helix type 11 domain protein BHV55_RS03405 ENOG4105NAE bifunctional deaminase-reductase domain protein BHV55_RS03410 ENOG4105BZU Histidine kinase BHV55_RS03415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS03440 ENOG41068KF Universal stress protein BHV55_RS03450 ENOG4105CXY transporter BHV55_RS03455 ENOG41067TZ transcriptional regulator, MarR family BHV55_RS03460 ENOG4105C0R drug resistance transporter emrb qaca subfamily BHV55_RS03465 ENOG4105ETE Transcriptional regulator (LacI family BHV55_RS03470 ENOG4108RVA ribokinase BHV55_RS03480 ENOG4105C2J ABC transporter BHV55_RS03485 ENOG4105CNN ABC, transporter BHV55_RS03490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BHV55_RS03495 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BHV55_RS03535 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BHV55_RS03565 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BHV55_RS03570 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BHV55_RS03575 ENOG41069ER domain protein BHV55_RS03580 ENOG4105VZ8 Transcriptional regulator BHV55_RS03585 ENOG4107D63 BHV55_RS03600 ENOG4105DUX Transporter BHV55_RS03620 ENOG4105C85 amino acid BHV55_RS03625 ENOG4105C7N Xanthine uracil vitamin C permease BHV55_RS03640 ENOG4105MA6 gCN5-related N-acetyltransferase BHV55_RS03665 ENOG4105BZ9 Cytochrome C oxidase, subunit I BHV55_RS03670 ENOG4105E2S oxidase) subunit II BHV55_RS03690 ENOG4106CAD Protein of unknown function (DUF3311) BHV55_RS03695 ENOG4105E1V na solute symporter BHV55_RS03710 ENOG4108NHD germination protein BHV55_RS03720 ENOG4105CE1 Ferrous iron transport protein b BHV55_RS03725 ENOG4105CE1 Ferrous iron transport protein b BHV55_RS03730 ENOG4105CE1 Ferrous iron transport protein b BHV55_RS03735 ENOG4105CVA phosphate BHV55_RS03740 ENOG4105C8U phosphate abc transporter BHV55_RS03745 ENOG4105E2Z phosphate ABC transporter (Permease BHV55_RS03870 ENOG41080XQ Signal transduction protein with cbs domains BHV55_RS03890 ENOG4105ETU transcriptional activator (TenA BHV55_RS03900 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BHV55_RS03910 ENOG4108VEU Thiamine monophosphate synthase BHV55_RS03915 ENOG41080HI glycine oxidase BHV55_RS03930 ENOG4105D06 uba thif-type nad fad binding protein BHV55_RS03935 ENOG4105DWF phosphomethylpyrimidine kinase BHV55_RS03985 ENOG4108INS Transcriptional regulator BHV55_RS04010 ENOG4105C19 ABC transporter BHV55_RS04020 ENOG4105C7N Xanthine uracil vitamin C permease BHV55_RS04030 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BHV55_RS04045 ENOG4105K63 Thioredoxin BHV55_RS04065 ENOG4108B31 Spore germination protein BHV55_RS04085 ENOG4107Y03 Nitroreductase BHV55_RS04090 ENOG4105ED1 spovr family BHV55_RS04100 ENOG4108TCS Glutamyl endopeptidase BHV55_RS04110 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BHV55_RS04115 ENOG4105XTG Pfam:DUF156 BHV55_RS04120 ENOG4105VFE sira family BHV55_RS04125 ENOG4107TPS domain protein BHV55_RS04130 ENOG4105VFE sira family BHV55_RS04135 ENOG4105VFE sira family BHV55_RS04145 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BHV55_RS04150 ENOG41087NI Sulfite exporter TauE/SafE BHV55_RS04160 ENOG4108KGH TRANSCRIPTIONal BHV55_RS04185 ENOG4105EMD TRANSCRIPTIONal BHV55_RS04190 ENOG4105VCP PTS System BHV55_RS04195 ENOG4105VZJ PTS System BHV55_RS04215 ENOG41069ER domain protein BHV55_RS04220 ENOG4107RBB ABC transporter, permease BHV55_RS04225 ENOG4105C19 ABC transporter BHV55_RS04255 ENOG4105WEF catalase BHV55_RS04290 ENOG4107T5V SNARE associated Golgi BHV55_RS04325 ENOG4105CUB amino acid BHV55_RS04330 ENOG4107RWR Sodium hydrogen exchanger BHV55_RS04340 ENOG4106KNT transcriptional regulator BHV55_RS04375 ENOG4108PCN EamA-like transporter family BHV55_RS04380 ENOG4108YXU transcriptional regulator AsnC family BHV55_RS04385 ENOG4105CH7 arginosuccinase BHV55_RS04390 ENOG4105UBK short-chain dehydrogenase reductase BHV55_RS04440 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BHV55_RS04445 ENOG4105E5W Transporter BHV55_RS04460 ENOG4107RKG DJ-1/PfpI family BHV55_RS04465 ENOG4105CH6 catalase BHV55_RS04475 ENOG4105D5Q Arginine ornithine antiporter BHV55_RS04480 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BHV55_RS04490 ENOG4105C26 Dehydrogenase BHV55_RS04495 ENOG4105BZ1 (ABC) transporter BHV55_RS04500 ENOG4105BZ1 (ABC) transporter BHV55_RS04510 ENOG4105DRP amino acid AbC transporter BHV55_RS04515 ENOG4105CDA abc transporter atp-binding protein BHV55_RS04530 ENOG410839P BHV55_RS04565 ENOG4107FQX Alpha-acetolactate decarboxylase BHV55_RS04570 ENOG4108VX5 3-methyladenine DNA glycosylase BHV55_RS04580 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BHV55_RS04585 ENOG4105D4P Coproporphyrinogen iii oxidase BHV55_RS04590 ENOG4105CEY Amp-dependent synthetase and ligase BHV55_RS04605 ENOG4105CHH sulfate transporter BHV55_RS04630 ENOG4105CGU Enoyl-CoA hydratase BHV55_RS04650 ENOG4105DER m42 family BHV55_RS04735 ENOG4108IBT Inherit from COG: transposase BHV55_RS04855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BHV55_RS04865 ENOG4108JQ7 (ABC) transporter BHV55_RS04875 ENOG4105CSH Transporter BHV55_RS04885 ENOG4108MRH transcriptional regulatory protein BHV55_RS04900 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BHV55_RS04920 ENOG4108HMN Caspase domain BHV55_RS05000 ENOG4105CDU Replicative dna helicase BHV55_RS05020 ENOG4105CDU Replicative dna helicase BHV55_RS05045 ENOG4108Z86 Glutamine amidotransferase BHV55_RS05065 ENOG4105C0R drug resistance transporter emrb qaca subfamily BHV55_RS05085 ENOG4105D9U N-acetyltransferase BHV55_RS05165 ENOG4105F6J Alpha beta hydrolase fold BHV55_RS05175 ENOG4105VZ8 Transcriptional regulator BHV55_RS05190 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BHV55_RS05255 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BHV55_RS05270 ENOG4105F27 Major Facilitator BHV55_RS05275 ENOG4105WAB arsR family transcriptional regulator BHV55_RS05300 ENOG4108NIW Leucine export protein LeuE BHV55_RS05305 ENOG4105CMT Dihydroxyacetone kinase BHV55_RS05315 ENOG4105CMT Dihydroxyacetone kinase BHV55_RS05345 ENOG41069ER domain protein BHV55_RS05425 ENOG4105WN5 stage II sporulation protein BHV55_RS05435 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHV55_RS05445 ENOG4108MJI response regulator BHV55_RS05450 ENOG4105BZU Histidine kinase BHV55_RS05455 ENOG4105BZU Histidine kinase BHV55_RS05500 ENOG4107QHE Choloylglycine hydrolase BHV55_RS05520 ENOG4107VRP DNA repair exonuclease BHV55_RS05525 ENOG4106D4I domain protein BHV55_RS05535 ENOG4105ED2 Beta-lactamase BHV55_RS05550 ENOG4107JM4 Tetratricopeptide repeat BHV55_RS05560 ENOG4108MUZ hydrolase BHV55_RS05575 ENOG4105F0F Oxalate decarboxylase BHV55_RS05585 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BHV55_RS05600 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BHV55_RS05615 ENOG4105EMN RNA polymerase sigma factor BHV55_RS05625 ENOG4105CNI cell division protein FtsW BHV55_RS05630 ENOG4105EEM helicase BHV55_RS05635 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BHV55_RS05660 ENOG4105K59 histidine triad (HIT) protein BHV55_RS05695 ENOG410905X membrane-flanked domain protein BHV55_RS05700 ENOG4105CKV Membrane BHV55_RS05745 ENOG410905X membrane-flanked domain protein BHV55_RS05750 ENOG4105CKV Membrane BHV55_RS05755 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BHV55_RS05760 ENOG4105BZ4 penicillin-binding protein BHV55_RS05770 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BHV55_RS05775 ENOG4105C1Q protoporphyrinogen oxidase BHV55_RS05800 ENOG4105NA0 Transcriptional regulator BHV55_RS05815 ENOG4105ECB domain protein BHV55_RS05855 ENOG4106AXD BHV55_RS05860 ENOG4108RQ5 Beta-lactamase domain-containing protein BHV55_RS05865 ENOG4105DF9 Lipoate-protein, ligase BHV55_RS05875 ENOG4105CEY Amp-dependent synthetase and ligase BHV55_RS05885 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BHV55_RS05890 ENOG4108I5D sulfate abc transporter BHV55_RS05895 ENOG4105ECW sulfate abc transporter BHV55_RS05900 ENOG4108IJ6 ABC transporter BHV55_RS05915 ENOG4105ENX hydrolase BHV55_RS05920 ENOG4107RN3 metallophosphoesterase BHV55_RS05925 ENOG4107TVP HD domain protein BHV55_RS05935 ENOG4108AEY RNA polymerase sigma factor BHV55_RS05940 ENOG41086D8 Transcriptional regulator BHV55_RS05955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHV55_RS05975 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BHV55_RS05980 ENOG4105C8Q Methyl-accepting chemotaxis BHV55_RS05985 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) BHV55_RS05995 ENOG4107QP3 malate synthase g BHV55_RS06095 ENOG4105ERH Fumarylacetoacetate hydrolase BHV55_RS06105 ENOG4105C8Y Acetylornithine aminotransferase BHV55_RS06120 ENOG4105CAQ asparagine synthetase BHV55_RS06125 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BHV55_RS06130 ENOG4105CH6 catalase BHV55_RS06135 ENOG4105BZU Histidine kinase BHV55_RS06155 ENOG4105QNR S1 RNA binding domain protein BHV55_RS06170 ENOG4105CNA YD repeat protein BHV55_RS06205 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BHV55_RS06215 ENOG4107AYK membrAne BHV55_RS06220 ENOG41073B9 BHV55_RS06230 ENOG4108KP7 hydrolase BHV55_RS06240 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BHV55_RS06275 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BHV55_RS06280 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BHV55_RS06295 ENOG4105C31 Tryptophanyl-tRNA synthetase BHV55_RS06310 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BHV55_RS06315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BHV55_RS06325 ENOG4108JQ7 (ABC) transporter BHV55_RS06330 ENOG4105UQX Mate efflux family protein BHV55_RS06350 ENOG4108ZCF integral membrane protein BHV55_RS06360 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BHV55_RS06370 ENOG4105DPN Oligoendopeptidase f BHV55_RS06385 ENOG4108Z18 K06886 hemoglobin BHV55_RS06390 ENOG4105MIX Adenylate cyclase BHV55_RS06405 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BHV55_RS06410 ENOG4105EMS pseudouridine synthase BHV55_RS06430 ENOG4105K64 Glycosyl transferase, family 2 BHV55_RS06450 ENOG4107TVC Glycosyl transferase, family 2 BHV55_RS06470 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BHV55_RS06475 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BHV55_RS06485 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BHV55_RS06565 ENOG4105CK7 Sodium proline symporter BHV55_RS06575 ENOG4105DDQ anthranilate synthase BHV55_RS06585 ENOG4105DK0 Indole-3-glycerol phosphate synthase BHV55_RS06665 ENOG4105C7S Dehydrogenase BHV55_RS06670 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BHV55_RS06675 ENOG4105VZ8 Transcriptional regulator BHV55_RS06745 ENOG4108NE4 BHV55_RS06780 ENOG4105EFC phage portal protein HK97 family BHV55_RS06800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BHV55_RS06825 ENOG4105DZ1 carboxypeptidase BHV55_RS06830 ENOG4105VFR signal peptidase BHV55_RS06865 ENOG4105C26 Dehydrogenase BHV55_RS06870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BHV55_RS06875 ENOG4105F38 ABC transporter, permease BHV55_RS06880 ENOG4105D38 putrescine abc transporter BHV55_RS06885 ENOG4108HM4 ABC transporter BHV55_RS06895 ENOG4105EYF MMPL domain protein BHV55_RS06905 ENOG4108YBP pseudouridine synthase BHV55_RS06915 ENOG4105K4I Scp-like extracellular BHV55_RS06920 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BHV55_RS06925 ENOG4105CQB FAD linked oxidase domain protein BHV55_RS06940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS06945 ENOG4105BZU Histidine kinase BHV55_RS06950 ENOG4105JXH GntR family transcriptional regulator BHV55_RS06970 ENOG4106A3R peptidase BHV55_RS06980 ENOG4108QTI )-transporter BHV55_RS06985 ENOG4107TS3 membrane protein, TerC BHV55_RS06990 ENOG4105CZN Potassium uptake protein BHV55_RS06995 ENOG410681C small acid-soluble spore protein BHV55_RS07000 ENOG4108Z7G MaoC domain protein dehydratase BHV55_RS07020 ENOG4105CHR reductase BHV55_RS07050 ENOG4105C4Y ABC transporter BHV55_RS07055 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BHV55_RS07060 ENOG4107RCV ABC transporter, permease BHV55_RS07080 ENOG4105E98 transcriptional regulator DeoR family BHV55_RS07090 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BHV55_RS07100 ENOG4105PXI polysaccharide deacetylase BHV55_RS07110 ENOG4105BZU Histidine kinase BHV55_RS07115 ENOG41090MY MarR family Transcriptional regulator BHV55_RS07125 ENOG4106DF1 BHV55_RS07130 ENOG4105BZU Histidine kinase BHV55_RS07135 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BHV55_RS07140 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BHV55_RS07145 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BHV55_RS07185 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BHV55_RS07190 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BHV55_RS07195 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BHV55_RS07200 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BHV55_RS07205 ENOG4105CZV ABC transporter BHV55_RS07215 ENOG4105CJ1 ABC, transporter BHV55_RS07255 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BHV55_RS07260 ENOG4105EA8 2-Nitropropane dioxygenase BHV55_RS07265 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BHV55_RS07275 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BHV55_RS07300 ENOG4105NQC Flavodoxin BHV55_RS07365 ENOG4105CZN Potassium uptake protein BHV55_RS07370 ENOG41063Y9 BHV55_RS07375 ENOG4105KBJ sporulation protein ytfj BHV55_RS07395 ENOG4105CM2 brancheD-chain amino acid aminotransferase BHV55_RS07400 ENOG4105C7K acetolactate synthase BHV55_RS07405 ENOG4108ZP8 Acetolactate synthase small subunit BHV55_RS07410 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BHV55_RS07425 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BHV55_RS07440 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BHV55_RS07445 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BHV55_RS07450 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BHV55_RS07455 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BHV55_RS07460 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BHV55_RS07465 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BHV55_RS07480 ENOG4107RVV histidinol phosphate phosphatase, hisj family BHV55_RS07495 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BHV55_RS07500 ENOG4105E0M Sulfatase BHV55_RS07510 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BHV55_RS07525 ENOG4107S4M Sulfate adenylate transferase BHV55_RS07530 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BHV55_RS07535 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BHV55_RS07545 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BHV55_RS07550 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BHV55_RS07555 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BHV55_RS07560 ENOG4105C8J )-transporter BHV55_RS07585 ENOG4105DFD Na H antiporter BHV55_RS07605 ENOG4105ENE Histidine kinase BHV55_RS07610 ENOG4105WH1 Two component transcriptional regulator luxr family BHV55_RS07630 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BHV55_RS07655 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BHV55_RS07675 ENOG4105CJ3 phosphate transporter BHV55_RS07680 ENOG4107GRR phosphate transport regulator BHV55_RS07685 ENOG4105BZ4 penicillin-binding protein BHV55_RS07700 ENOG4105BZU Histidine kinase BHV55_RS07705 ENOG4105I3N Conserved Protein BHV55_RS07720 ENOG4105BZU Histidine kinase BHV55_RS07750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BHV55_RS07755 ENOG4105DZ1 carboxypeptidase BHV55_RS07760 ENOG4108JIC nucleoside recognition domain protein BHV55_RS07770 ENOG4105FE9 pseudouridine synthase BHV55_RS07775 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BHV55_RS07780 ENOG4107TWT Cytochrome c biogenesis protein BHV55_RS07785 ENOG4105CRE cytochrome C BHV55_RS07790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS07795 ENOG4105BZU Histidine kinase BHV55_RS07800 ENOG4108WBT adenosyltransferase BHV55_RS07815 ENOG4108SAX Membrane BHV55_RS07830 ENOG4105C9U ATP-dependent DNA helicase RecQ BHV55_RS07835 ENOG4105I7S Abortive infection protein BHV55_RS07845 ENOG4107RGJ metallophosphoesterase BHV55_RS07850 ENOG4108XDN Transcriptional regulator BHV55_RS07855 ENOG4108S6Z Negative regulator of genetic competence BHV55_RS07880 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BHV55_RS07885 ENOG4107RB3 L-asparaginase BHV55_RS07905 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BHV55_RS07920 ENOG4105S2F BHV55_RS07925 ENOG41065D1 BHV55_RS07955 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BHV55_RS07970 ENOG4105XXQ heptaprenyl diphosphate synthase component I BHV55_RS07980 ENOG4105EAH synthase BHV55_RS07985 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BHV55_RS07990 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BHV55_RS08005 ENOG41068YB TPR repeat-containing protein BHV55_RS08020 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BHV55_RS08025 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BHV55_RS08060 ENOG4108JYZ YitT family BHV55_RS08065 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BHV55_RS08080 ENOG4105FJR Lmbe family BHV55_RS08085 ENOG4105CPK Glycosyl transferase (Group 1 BHV55_RS08100 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BHV55_RS08115 ENOG4105DVT helicase BHV55_RS08120 ENOG4105YAC BHV55_RS08140 ENOG4105CSM endonuclease III BHV55_RS08150 ENOG4105BZ4 penicillin-binding protein BHV55_RS08205 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BHV55_RS08215 ENOG4105DVT helicase BHV55_RS08220 ENOG4105CTD carboxy-peptidase BHV55_RS08230 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BHV55_RS08240 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BHV55_RS08245 ENOG4105C2W permease BHV55_RS08250 ENOG4105DHF Membrane BHV55_RS08255 ENOG410890F Dynamin family BHV55_RS08265 ENOG4108W0I acetyltransferase BHV55_RS08275 ENOG4105KHC sulfurtransferase BHV55_RS08330 ENOG4105HTX biosynthesis protein BHV55_RS08360 ENOG4105CPK Glycosyl transferase (Group 1 BHV55_RS08375 ENOG4108SZE gCN5-related N-acetyltransferase BHV55_RS08395 ENOG41081VK Ribonuclease BHV55_RS08460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BHV55_RS08470 ENOG4107RWR Sodium hydrogen exchanger BHV55_RS08475 ENOG4105CN5 Metallo-Beta-Lactamase BHV55_RS08480 ENOG4108Z5V transcriptional regulator, merr family BHV55_RS08490 ENOG4105H67 Protein of unknown function (DUF421) BHV55_RS08495 ENOG41080C8 DUF218 domain BHV55_RS08530 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BHV55_RS08540 ENOG4107R0U MotA TolQ exbB proton channel BHV55_RS08545 ENOG4105ER2 Ompa motb domain protein BHV55_RS08550 ENOG4107YTP response regulator receiver protein BHV55_RS08555 ENOG4105CBS Chea signal transduction histidine kinase BHV55_RS08560 ENOG4105DD5 Flagellar motor switch protein BHV55_RS08575 ENOG4105BZU Histidine kinase BHV55_RS08595 ENOG4105E1Q flagellar hook-associated protein BHV55_RS08600 ENOG4105DTJ flagellar hook-associated protein BHV55_RS08620 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BHV55_RS08625 ENOG4108ZC9 flagellar basal-body rod protein flgc BHV55_RS08635 ENOG4107U2N Flagellar M-ring protein BHV55_RS08640 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BHV55_RS08670 ENOG4105BZE flagellar hook protein, FlgE BHV55_RS08685 ENOG4107R88 Chemotaxis protein (CheV) BHV55_RS08695 ENOG4105I03 Flagellin BHV55_RS08700 ENOG4105I03 Flagellin BHV55_RS08705 ENOG4105E4C Lytic transglycosylase catalytic BHV55_RS08715 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BHV55_RS08720 ENOG4105DD5 Flagellar motor switch protein BHV55_RS08730 ENOG4105CN7 Flagellar biosynthetic protein FliP BHV55_RS08735 ENOG4105VS8 Flagellar biosynthetic protein fliq BHV55_RS08745 ENOG4105D00 flagellar biosynthetic protein flhB BHV55_RS08750 ENOG4105D7B Flagellar biosynthesis protein flha BHV55_RS08755 ENOG4105FZW flagellar biosynthesis regulator FlhF BHV55_RS08760 ENOG4105KTQ flagellar basal-body rod protein BHV55_RS08765 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BHV55_RS08800 ENOG4105KAC Antibiotic biosynthesis monooxygenase BHV55_RS08830 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BHV55_RS08835 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BHV55_RS08840 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BHV55_RS08875 ENOG4105CVJ phosphoglycerate mutase BHV55_RS08885 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BHV55_RS08905 ENOG4105CAQ asparagine synthetase BHV55_RS08925 ENOG4105PGM cation diffusion facilitator family transporter BHV55_RS08935 ENOG4105DRR Transcriptional regulator, GntR family BHV55_RS08940 ENOG4108UZ3 Transporter BHV55_RS08950 ENOG4105CKI cobalamin synthesis protein BHV55_RS08955 ENOG4108PJD permease BHV55_RS08970 ENOG4105DFD Na H antiporter BHV55_RS08985 ENOG4105C9Q fumarate hydratase class II BHV55_RS09005 ENOG4107QJQ Mate efflux family protein BHV55_RS09010 ENOG4105EC3 peptidase S51, dipeptidase E BHV55_RS09025 ENOG4105D0M Protease HtpX homolog BHV55_RS09035 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BHV55_RS09050 ENOG4107JM4 Tetratricopeptide repeat BHV55_RS09070 ENOG4106BRA Membrane BHV55_RS09105 ENOG4105CJ1 ABC, transporter BHV55_RS09130 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BHV55_RS09140 ENOG4108IJ0 Aspartate ammonia-lyase BHV55_RS09145 ENOG4105C6K Malic enzyme BHV55_RS09195 ENOG4105FVX BHV55_RS09210 ENOG4105CSR polyphosphate kinase 2 BHV55_RS09215 ENOG4105U3E Transcriptional regulator BHV55_RS09225 ENOG4105DXI Major Facilitator superfamily BHV55_RS09235 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BHV55_RS09240 ENOG4105EU0 Major facilitator Superfamily BHV55_RS09245 ENOG4105C6T cysteine synthase BHV55_RS09265 ENOG4105C8J )-transporter BHV55_RS09270 ENOG4105X5K response regulator receiver protein BHV55_RS09275 ENOG4105H67 Protein of unknown function (DUF421) BHV55_RS09295 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BHV55_RS09300 ENOG4105CHR reductase BHV55_RS09305 ENOG4105CM2 brancheD-chain amino acid aminotransferase BHV55_RS09310 ENOG4105C7K acetolactate synthase BHV55_RS09320 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BHV55_RS09325 ENOG4105C01 Dihydroxy-acid dehydratase BHV55_RS09330 ENOG4105C7B Threonine dehydratase BHV55_RS09355 ENOG4105C6X Major Facilitator BHV55_RS09360 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BHV55_RS09370 ENOG4105DY9 regulatoR BHV55_RS09375 ENOG4105CYC Transferase BHV55_RS09380 ENOG4105K5X acetyltransferase BHV55_RS09400 ENOG41068WN BHV55_RS09405 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BHV55_RS09420 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BHV55_RS09425 ENOG4105C0X amino acid BHV55_RS09450 ENOG4105K8R UPF0145 protein BHV55_RS09470 ENOG4107RHR regulatoR BHV55_RS09480 ENOG4105D9N nucleoside BHV55_RS09485 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BHV55_RS09525 ENOG4107RAQ aminopeptidase BHV55_RS09535 ENOG4107R16 Multicopper oxidase BHV55_RS09575 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BHV55_RS09620 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BHV55_RS09625 ENOG4108KP7 hydrolase BHV55_RS09630 ENOG4105C8V SAICAR synthetase BHV55_RS09640 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BHV55_RS09645 ENOG4105CHR reductase BHV55_RS09655 ENOG4105D9U N-acetyltransferase BHV55_RS09665 ENOG4108T5E Copper resistance protein BHV55_RS09670 ENOG4105KTB nuclear export factor GLE1 BHV55_RS09675 ENOG4107RT3 EamA-like transporter family BHV55_RS09680 ENOG4105GZI Transcriptional regulator BHV55_RS09685 ENOG4108Z40 Transcriptional regulator BHV55_RS09690 ENOG4107ZXU DSBA oxidoreductase BHV55_RS09695 ENOG4108TVJ Nitroreductase BHV55_RS09700 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BHV55_RS09705 ENOG4106F5Q Membrane BHV55_RS09710 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BHV55_RS09720 ENOG4105CKI cobalamin synthesis protein BHV55_RS09730 ENOG4105C0Z ABC transporter BHV55_RS09735 ENOG4108IV0 ABC, transporter BHV55_RS09740 ENOG4105C32 Amino acid ABC transporter (Permease) BHV55_RS09750 ENOG4105SKE transcriptional Regulator LysR family BHV55_RS09760 ENOG4105MDS 4-oxalocrotonate tautomerase BHV55_RS09780 ENOG4105C4M (Ubiquinol oxidase) subunit I BHV55_RS09785 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BHV55_RS09790 ENOG4108JJ9 ABC, transporter BHV55_RS09795 ENOG4108JJ8 (ABC) transporter BHV55_RS09805 ENOG4105K64 Glycosyl transferase, family 2 BHV55_RS09815 ENOG4108UT6 Transferase hexapeptide repeat containing protein BHV55_RS09870 ENOG4105BZ1 (ABC) transporter BHV55_RS09875 ENOG4105EFI regulatoR BHV55_RS09880 ENOG4105BZU Histidine kinase BHV55_RS09890 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BHV55_RS09915 ENOG4105D6E homoserine dehydrogenase BHV55_RS09925 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BHV55_RS09940 ENOG4108KGH TRANSCRIPTIONal BHV55_RS09950 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHV55_RS09955 ENOG4105BZU Histidine kinase BHV55_RS09970 ENOG4105KT7 mgtC SapB transporter BHV55_RS09975 ENOG4105VRR gCN5-related N-acetyltransferase BHV55_RS09985 ENOG4105DUU IucA IucC family protein BHV55_RS09990 ENOG4105CEY Amp-dependent synthetase and ligase BHV55_RS10005 ENOG4108WBH protein TIM barrel BHV55_RS10010 ENOG4105YWU small acid-soluble spore protein BHV55_RS10020 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BHV55_RS10025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BHV55_RS10075 ENOG4105KRN Transcriptional regulator, abrb family BHV55_RS10115 ENOG4105C8Q Methyl-accepting chemotaxis BHV55_RS10130 ENOG4108K88 Membrane BHV55_RS10135 ENOG4108WPJ Ferritin-like domain BHV55_RS10150 ENOG4105DEN Luciferase family BHV55_RS10165 ENOG4105VMI -acetyltransferase BHV55_RS10170 ENOG4107QM2 Aldo Keto reductase BHV55_RS10180 ENOG4105CKI cobalamin synthesis protein BHV55_RS10190 ENOG4105DSE periplasmic solute binding protein BHV55_RS10200 ENOG4105K4T epimerase BHV55_RS10210 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BHV55_RS10255 ENOG4107T5V SNARE associated Golgi BHV55_RS10270 ENOG4108PJD permease BHV55_RS10280 ENOG4108S4H thioesterase Superfamily protein BHV55_RS10290 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BHV55_RS10310 ENOG4105SXS Protein of unknown function (DUF456) BHV55_RS10315 ENOG4105C37 (CBS) domain BHV55_RS10335 ENOG4108Z7R Chaperone CsaA BHV55_RS10355 ENOG4108ZRV stage ii sporulation protein p BHV55_RS10365 ENOG4108VXD carboxy-peptidase BHV55_RS10390 ENOG4108ZRV stage ii sporulation protein p BHV55_RS10400 ENOG4108X4Q Hydrolase BHV55_RS10415 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BHV55_RS10430 ENOG41087PP glycosyltransferase MGT family BHV55_RS10435 ENOG4108JYZ YitT family BHV55_RS10440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BHV55_RS10470 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BHV55_RS10505 ENOG4108MGT Required for secretion of EsxA and EsxB BHV55_RS10555 ENOG4105KBJ sporulation protein ytfj BHV55_RS10580 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BHV55_RS10600 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BHV55_RS10605 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BHV55_RS10615 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BHV55_RS10620 ENOG4105EMN RNA polymerase sigma factor BHV55_RS10635 ENOG4105CNW domain protein BHV55_RS10645 ENOG4108V06 Glutathione peroxidase BHV55_RS10660 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BHV55_RS10670 ENOG4108IUE nitrate reductase beta subunit BHV55_RS10675 ENOG4105R3A Nitrate reductase BHV55_RS10685 ENOG4107V6Q Cyclic nucleotide-binding domain BHV55_RS10690 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BHV55_RS10695 ENOG4105D06 uba thif-type nad fad binding protein BHV55_RS10700 ENOG4105CVM Molybdenum cofactor synthesis domain protein BHV55_RS10705 ENOG4108ZAF Molybdopterin BHV55_RS10710 ENOG41067WU Molybdopterin converting factor (Subunit 1) BHV55_RS10735 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BHV55_RS10740 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BHV55_RS10745 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BHV55_RS10750 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BHV55_RS10755 ENOG4108IFG nitrite reductase, (NAD(P)H) BHV55_RS10760 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BHV55_RS10795 ENOG4105MCT stage V sporulation protein S BHV55_RS10850 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BHV55_RS10885 ENOG4105C5H ABC transporter BHV55_RS10900 ENOG4108UUM single-stranded DNA-binding protein BHV55_RS10930 ENOG4107YX5 Pfam:DUF548 BHV55_RS10935 ENOG4105C75 arginyL-tRNA synthetase BHV55_RS10960 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BHV55_RS10975 ENOG4105C5S asparaginyl-tRNA synthetase BHV55_RS10980 ENOG4105C8J )-transporter BHV55_RS11000 ENOG4107XGZ Hydrolase BHV55_RS11005 ENOG4105CY2 Citrate transporter BHV55_RS11025 ENOG4105KD7 acetyltransferase BHV55_RS11035 ENOG4105VMP Transcriptional regulator BHV55_RS11040 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BHV55_RS11065 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BHV55_RS11080 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BHV55_RS11085 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BHV55_RS11095 ENOG4107RVG penicillin-binding protein BHV55_RS11100 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BHV55_RS11105 ENOG4105E9Q Acyl-transferase BHV55_RS11110 ENOG4108UT2 hemolysin iii BHV55_RS11120 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BHV55_RS11130 ENOG4108RCR degv family BHV55_RS11140 ENOG4108KF3 Electron transport protein SCO1 SenC BHV55_RS11145 ENOG4107Y70 Heat shock protein BHV55_RS11150 ENOG4105CAQ asparagine synthetase BHV55_RS11165 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BHV55_RS11170 ENOG4108MES Periplasmic binding protein BHV55_RS11175 ENOG4105F0I Aminotransferase BHV55_RS11210 ENOG4105D8X mechanosensitive ion channel BHV55_RS11215 ENOG4105BZU Histidine kinase BHV55_RS11220 ENOG4105WH1 Two component transcriptional regulator luxr family BHV55_RS11225 ENOG4106KNT transcriptional regulator BHV55_RS11230 ENOG4107ZY0 Phenazine biosynthesis-like protein BHV55_RS11250 ENOG4105CMG Carbohydrate kinase BHV55_RS11255 ENOG4105C6Z Gluconate BHV55_RS11295 ENOG4108IJ8 ABC transporter BHV55_RS11300 ENOG4105E90 ABC transporter BHV55_RS11335 ENOG4105C37 (CBS) domain BHV55_RS11360 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BHV55_RS11375 ENOG4107S4Y M20 DapE family protein YgeY BHV55_RS11380 ENOG4108TSC N-acetyltransferase BHV55_RS11385 ENOG4108JUB Transcriptional regulator BHV55_RS11390 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BHV55_RS11435 ENOG410841Q phosphoesterase PA-phosphatase related protein BHV55_RS11445 ENOG4105SZ6 Thioredoxin BHV55_RS11480 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BHV55_RS11535 ENOG4105BZ4 penicillin-binding protein BHV55_RS11545 ENOG4105CZM Major Facilitator BHV55_RS11550 ENOG4105W8X HesB YadR YfhF-family protein BHV55_RS11560 ENOG4105DXD 2-methylcitrate dehydratase BHV55_RS11565 ENOG4105CR4 methylisocitrate lyase BHV55_RS11570 ENOG4105C1G acyl-Coa dehydrogenase BHV55_RS11575 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BHV55_RS11585 ENOG4105N14 lysine exporter protein LysE YggA BHV55_RS11590 ENOG4105E39 Enoyl-CoA hydratase BHV55_RS11605 ENOG4107RFY SbcCD D subunit BHV55_RS11610 ENOG4105EYH Exonuclease BHV55_RS11630 ENOG4105FCD Major Facilitator BHV55_RS11635 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BHV55_RS11640 ENOG4105E4F Isochorismate synthase BHV55_RS11645 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BHV55_RS11650 ENOG4105WQI isochorismatase BHV55_RS11655 ENOG4105CEY Amp-dependent synthetase and ligase BHV55_RS11660 ENOG4105WQT MbtH domain protein BHV55_RS11665 ENOG4105C0R drug resistance transporter emrb qaca subfamily BHV55_RS11680 ENOG4105K70 DNA-binding protein BHV55_RS11700 ENOG4105BZG amino acid carrier protein BHV55_RS11720 ENOG4105FE9 pseudouridine synthase BHV55_RS11725 ENOG4105C22 threonyL-tRNA synthetase BHV55_RS11730 ENOG4105C19 ABC transporter BHV55_RS11785 ENOG41081I9 integral membrane protein BHV55_RS11795 ENOG4108Y4K DNA-binding transcriptional activator BHV55_RS11830 ENOG4105EYF MMPL domain protein BHV55_RS11855 ENOG4105WCN acetyltransferase BHV55_RS11880 ENOG4105C1Q protoporphyrinogen oxidase BHV55_RS11890 ENOG41068WN BHV55_RS11920 ENOG4107V2S Transcriptional regulator BHV55_RS11925 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BHV55_RS11945 ENOG4105DND Transcriptional regulator BHV55_RS11950 ENOG4108RPX mosc domain containing protein BHV55_RS11965 ENOG4105BZ1 (ABC) transporter BHV55_RS11970 ENOG4105BZ1 (ABC) transporter BHV55_RS11995 ENOG4108JCI Transcriptional regulator BHV55_RS12035 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BHV55_RS12040 ENOG4108KPJ rna polymerase sigma factor BHV55_RS12065 ENOG4105F32 YngK protein BHV55_RS12090 ENOG4105RD7 BadF BadG BcrA BcrD BHV55_RS12100 ENOG4107STF Involved in phosphonate degradation (By similarity) BHV55_RS12110 ENOG4108INS Transcriptional regulator BHV55_RS12130 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BHV55_RS12140 ENOG4105C1J atp-dependent rna helicase BHV55_RS12150 ENOG4108RZE Tetr family transcriptional regulator BHV55_RS12170 ENOG41088CC tellurite resistance protein tehB BHV55_RS12180 ENOG4108I0C methyltransferase BHV55_RS12185 ENOG4107RA9 decarboxylase BHV55_RS12190 ENOG4105K56 Transcriptional regulator BHV55_RS12195 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BHV55_RS12220 ENOG4105CIN aminoacyl-histidine dipeptidase BHV55_RS12245 ENOG4105KRN Transcriptional regulator, abrb family BHV55_RS12255 ENOG4105EJ9 Membrane BHV55_RS12260 ENOG4105EQK -acetyltransferase BHV55_RS12310 ENOG4105CHR reductase BHV55_RS12430 ENOG4105EJQ L-serine dehydratase BHV55_RS12435 ENOG4105C44 Serine transporter BHV55_RS12455 ENOG4105F6S Spore photoproduct lyase BHV55_RS12465 ENOG4105CVK Glutamate decarboxylase BHV55_RS12490 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BHV55_RS12495 ENOG4105CNI cell division protein FtsW BHV55_RS12500 ENOG4105CJW magnesium transporter BHV55_RS12510 ENOG4107RVG penicillin-binding protein BHV55_RS12525 ENOG4107RF6 penicillin-binding protein BHV55_RS12530 ENOG4107RF6 penicillin-binding protein BHV55_RS12540 ENOG4105DIN metallophosphoesterase BHV55_RS12550 ENOG4105CJ1 ABC, transporter BHV55_RS12560 ENOG4107Z3H Transcriptional regulator, TetR family BHV55_RS12575 ENOG4105C1G acyl-Coa dehydrogenase BHV55_RS12580 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BHV55_RS12585 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BHV55_RS12590 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BHV55_RS12595 ENOG4105E39 Enoyl-CoA hydratase BHV55_RS12600 ENOG4107QX3 carboxylase BHV55_RS12605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BHV55_RS12635 ENOG4105DBI uridine monophosphokinase BHV55_RS12660 ENOG4105DZ1 carboxypeptidase BHV55_RS12675 ENOG4105T9C HD domain BHV55_RS12685 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BHV55_RS12705 ENOG41075H3 AraC family transcriptional regulator BHV55_RS12740 ENOG4107Y80 Major Facilitator superfamily BHV55_RS12750 ENOG4105KVH Transcriptional regulator BHV55_RS12755 ENOG41089UC methyltransferase, type 11 BHV55_RS12785 ENOG4105CUV Homoserine Kinase BHV55_RS12790 ENOG4108DMH HTH_ARAC BHV55_RS12800 ENOG4105SX7 Transporter BHV55_RS12810 ENOG4105EFA 4-hydroxyphenylacetate BHV55_RS12825 ENOG4105CPQ Dehydrogenase BHV55_RS12835 ENOG410900G Protein of unknown function (DUF421) BHV55_RS12845 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BHV55_RS12855 ENOG4105DK7 lysyl-tRNA synthetase BHV55_RS12915 ENOG4105D6E homoserine dehydrogenase BHV55_RS12925 ENOG4105CPF Cell wall formation (By similarity) BHV55_RS12930 ENOG4105ETU transcriptional activator (TenA BHV55_RS13025 ENOG410667J hydrolase BHV55_RS13030 ENOG4105BZU Histidine kinase BHV55_RS13035 ENOG4107RF6 penicillin-binding protein BHV55_RS13060 ENOG4108JJB ABC transporter BHV55_RS13080 ENOG4105VTR Integrase BHV55_RS13150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS13155 ENOG4105GR3 Histidine kinase BHV55_RS13160 ENOG4105CB2 alcohol dehydrogenase BHV55_RS13165 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BHV55_RS13170 ENOG4105CJN penicillin-binding protein BHV55_RS13220 ENOG4108V4B ThiJ pfpI BHV55_RS13230 ENOG4105F27 Major Facilitator BHV55_RS13235 ENOG4107Y80 Major Facilitator superfamily BHV55_RS13250 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BHV55_RS13275 ENOG4107Y9U Membrane BHV55_RS13295 ENOG4105EGD dinuclear metal center protein, YbgI family BHV55_RS13320 ENOG4105FCD Major Facilitator BHV55_RS13330 ENOG4105E09 nadh pyrophosphatase BHV55_RS13335 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BHV55_RS13355 ENOG4108XI2 Domain of unknown function (DUF1963) BHV55_RS13375 ENOG4108NRW Phospholipase, patatin family BHV55_RS13380 ENOG4105KWG Pfam:DUF1696 BHV55_RS13405 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BHV55_RS13415 ENOG4105PKS Excinuclease abc c subunit domain protein BHV55_RS13455 ENOG4107VFR oxidoreductase BHV55_RS13490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS13495 ENOG4105BZU Histidine kinase BHV55_RS13515 ENOG4107WD8 ABC transporter, permease BHV55_RS13530 ENOG4105DY8 decarboxylase BHV55_RS13545 ENOG4108IUM Glycogen debranching enzyme BHV55_RS13555 ENOG4105CGH 5'-nucleotidase BHV55_RS13570 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BHV55_RS13575 ENOG4105FDR Membrane BHV55_RS13580 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BHV55_RS13630 ENOG4105MSI germination protein ypeb BHV55_RS13660 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BHV55_RS13665 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BHV55_RS13670 ENOG4107Z3H Transcriptional regulator, TetR family BHV55_RS13700 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BHV55_RS13715 ENOG4105E98 transcriptional regulator DeoR family BHV55_RS13730 ENOG41062ES Transcriptional regulator BHV55_RS13750 ENOG4107QKR Dehydrogenase BHV55_RS13760 ENOG4107RUY (E1 component), alpha subunit BHV55_RS13770 ENOG4105JHE Major Facilitator Superfamily BHV55_RS13780 ENOG4105E1F short-chain dehydrogenase reductase BHV55_RS13810 ENOG4107SQ8 Glycine betaine BHV55_RS13815 ENOG4108IJ7 Glycine betaine BHV55_RS13840 ENOG4105E66 phosphoriboisomerase A BHV55_RS13845 ENOG41082BV acetyltransferase BHV55_RS13850 ENOG4108M1A Chitin-binding protein BHV55_RS13880 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BHV55_RS13885 ENOG4105MSB protein, conserved in bacteria BHV55_RS13910 ENOG4108Z7F N-acetyltransferase BHV55_RS13930 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BHV55_RS13935 ENOG4105EEM helicase BHV55_RS13945 ENOG41066HZ AIG2-like family BHV55_RS13950 ENOG4105C9U ATP-dependent DNA helicase RecQ BHV55_RS13995 ENOG4108M1A Chitin-binding protein BHV55_RS14010 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BHV55_RS14020 ENOG4105BZG amino acid carrier protein BHV55_RS14025 ENOG4105C26 Dehydrogenase BHV55_RS14030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BHV55_RS14035 ENOG4105CTU Proline racemase BHV55_RS14040 ENOG4105CTU Proline racemase BHV55_RS14045 ENOG41080HI glycine oxidase BHV55_RS14055 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BHV55_RS14090 ENOG4105DCI Phosphohydrolase BHV55_RS14095 ENOG4107T5V SNARE associated Golgi BHV55_RS14105 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BHV55_RS14125 ENOG4105DTQ mandelate racemase muconate lactonizing BHV55_RS14140 ENOG4107SET aldo keto reductase BHV55_RS14180 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BHV55_RS14185 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BHV55_RS14190 ENOG4105BZU Histidine kinase BHV55_RS14195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS14215 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BHV55_RS14230 ENOG4105DPN Oligoendopeptidase f BHV55_RS14235 ENOG4105DVH amino acid BHV55_RS14245 ENOG4105EPR degv family BHV55_RS14305 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BHV55_RS14310 ENOG4106K7D Major facilitator family transporter BHV55_RS14335 ENOG4107BMA Transglycosylase associated protein BHV55_RS14350 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BHV55_RS14385 ENOG4105CHM Aminotransferase BHV55_RS14400 ENOG4108ZMI UPF0477 protein BHV55_RS14455 ENOG4105C02 permease BHV55_RS14465 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BHV55_RS14470 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BHV55_RS14475 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BHV55_RS14480 ENOG4105D7T ABC transporter BHV55_RS14505 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BHV55_RS14550 ENOG4107VC0 DNA alkylation repair enzyme BHV55_RS14555 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BHV55_RS14570 ENOG4108ZCF integral membrane protein BHV55_RS14575 ENOG4105E0M Sulfatase BHV55_RS14580 ENOG4105C5H ABC transporter BHV55_RS14585 ENOG4105EYF MMPL domain protein BHV55_RS14590 ENOG41082JN Transcriptional regulator BHV55_RS14615 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BHV55_RS14620 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BHV55_RS14640 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) BHV55_RS14665 ENOG41069ER domain protein BHV55_RS14680 ENOG4105DNP FAD linked oxidase domain protein BHV55_RS14685 ENOG4105C57 major facilitator superfamily BHV55_RS14690 ENOG4105MKU Transcriptional regulator BHV55_RS14720 ENOG4105D4B ABC, transporter BHV55_RS14725 ENOG4105F5R ABC transporter BHV55_RS14730 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BHV55_RS14740 ENOG4105DKT Transcriptional regulator BHV55_RS14745 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BHV55_RS14755 ENOG41061GT Aldolase BHV55_RS14765 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BHV55_RS14800 ENOG4105II7 pyrroline-5-carboxylate reductase BHV55_RS14810 ENOG4107258 Transcriptional regulator BHV55_RS14825 ENOG4105ECK Fatty Acid Desaturase BHV55_RS14835 ENOG4107RBI VanW family BHV55_RS14840 ENOG4105G6Z alkaline phosphatase BHV55_RS14850 ENOG4105VMP Transcriptional regulator BHV55_RS14870 ENOG41068WN BHV55_RS14895 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BHV55_RS14915 ENOG4105CSH Transporter BHV55_RS14925 ENOG4105CKK Glycosyl transferase, family 2 BHV55_RS14955 ENOG4105C8Y Acetylornithine aminotransferase BHV55_RS15000 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BHV55_RS15035 ENOG4108IBT Inherit from COG: transposase BHV55_RS15055 ENOG4108TVJ Nitroreductase BHV55_RS15060 ENOG4105FS7 Transcriptional regulator BHV55_RS15075 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BHV55_RS15080 ENOG4105WEC Molybdate metabolism regulator BHV55_RS15090 ENOG4105CMR udp-glucose 4-epimerase BHV55_RS15095 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BHV55_RS15120 ENOG4108DMH HTH_ARAC BHV55_RS15125 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BHV55_RS15135 ENOG4108XET gCN5-related N-acetyltransferase BHV55_RS15150 ENOG4108PCN EamA-like transporter family BHV55_RS15195 ENOG410635A Membrane BHV55_RS15205 ENOG4108IQI permease BHV55_RS15215 ENOG4105F1N DNA alkylation repair BHV55_RS15245 ENOG4107RF6 penicillin-binding protein BHV55_RS15275 ENOG4105E7W lamb ycsf family protein BHV55_RS15285 ENOG4105P4J Allophanate hydrolase, subunit 1 BHV55_RS15290 ENOG4107258 Transcriptional regulator BHV55_RS15300 ENOG4106N3A copper homeostasis protein cutc BHV55_RS15310 ENOG4105CFI type iii restriction protein res subunit BHV55_RS15320 ENOG4105FDT acyl-CoA dehydrogenase BHV55_RS15335 ENOG4105DWD nucleoside recognition domain protein BHV55_RS15375 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BHV55_RS15385 ENOG4105CAQ asparagine synthetase BHV55_RS15390 ENOG4105DND Transcriptional regulator BHV55_RS15430 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BHV55_RS15455 ENOG4105E2A Dehydrogenase BHV55_RS15465 ENOG4108IJ0 Aspartate ammonia-lyase BHV55_RS15470 ENOG4105HDK L-asparaginase BHV55_RS15475 ENOG4108IMY Transcriptional regulator BHV55_RS15500 ENOG4108B31 Spore germination protein BHV55_RS15510 ENOG4105BZU Histidine kinase BHV55_RS15535 ENOG41075H3 AraC family transcriptional regulator BHV55_RS15545 ENOG4105YWU small acid-soluble spore protein BHV55_RS15550 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BHV55_RS15555 ENOG4105CUB amino acid BHV55_RS15560 ENOG4105II7 pyrroline-5-carboxylate reductase BHV55_RS15565 ENOG4108NHD germination protein BHV55_RS15570 ENOG4108Q8B Spore germination protein BHV55_RS15615 ENOG4105CGH 5'-nucleotidase BHV55_RS15625 ENOG4105CHJ isochorismatase hydrolase BHV55_RS15655 ENOG4105EQ0 Major Facilitator superfamily BHV55_RS15710 ENOG4105F6J Alpha beta hydrolase fold BHV55_RS15725 ENOG4108606 TspO/MBR family BHV55_RS15730 ENOG4105CVP deoxyribo-dipyrimidine photolyase BHV55_RS15740 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) BHV55_RS15775 ENOG4105F2M alpha beta hydrolase fold-3 domain protein BHV55_RS15790 ENOG4108TWJ NADH dehydrogenase subunit 5 BHV55_RS15795 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BHV55_RS15800 ENOG4105F27 Major Facilitator BHV55_RS15805 ENOG4106P55 Transcriptional regulator BHV55_RS15825 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BHV55_RS15835 ENOG4105D6J arsenicaL-resistance protein BHV55_RS15840 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BHV55_RS15845 ENOG41085FC arsR family transcriptional regulator BHV55_RS16000 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BHV55_RS16005 ENOG4105C0R drug resistance transporter emrb qaca subfamily BHV55_RS16020 ENOG4105K6H D-cysteine desulfhydrase BHV55_RS16030 ENOG4105E0Y RtcB Protein BHV55_RS16040 ENOG4105JQZ Methyltransferase BHV55_RS16060 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BHV55_RS16065 ENOG4105BZU Histidine kinase BHV55_RS16075 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BHV55_RS16110 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BHV55_RS16145 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BHV55_RS16305 ENOG4108VXD carboxy-peptidase BHV55_RS16310 ENOG4105PNM synthesis protein BHV55_RS16320 ENOG4108ISG Major Facilitator BHV55_RS16335 ENOG4107MII Sugar-specific transcriptional regulator TrmB BHV55_RS16340 ENOG4105CZM Major Facilitator BHV55_RS16355 ENOG4105CRW Short chain fatty acid transporter BHV55_RS16425 ENOG4108K8S endonuclease I BHV55_RS16440 ENOG4108Z66 YbaK ebsC protein BHV55_RS16465 ENOG4105KVH Transcriptional regulator BHV55_RS16470 ENOG4108RCM Nitroreductase BHV55_RS16500 ENOG4108PSK reductase BHV55_RS16575 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BHV55_RS16610 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BHV55_RS16620 ENOG4105EV4 Multidrug resistance protein mdtH BHV55_RS16650 ENOG4105C37 (CBS) domain BHV55_RS16665 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BHV55_RS16670 ENOG4105FAW cDP-glucose 4,6-dehydratase BHV55_RS16705 ENOG4105DDN Pentapeptide repeat-containing protein BHV55_RS16710 ENOG4105XDF Protein of unknown function (DUF1272) BHV55_RS16715 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BHV55_RS16720 ENOG4105CMG Carbohydrate kinase BHV55_RS16725 ENOG4105C6Z Gluconate BHV55_RS16730 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BHV55_RS16740 ENOG4105CV1 Transketolase (EC 2.2.1.1) BHV55_RS16745 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BHV55_RS16770 ENOG4105C8Q Methyl-accepting chemotaxis BHV55_RS16775 ENOG4108UX3 '-nucleotidase BHV55_RS16780 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BHV55_RS16785 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BHV55_RS16790 ENOG4105KVH Transcriptional regulator BHV55_RS16815 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BHV55_RS16820 ENOG4105CHH sulfate transporter BHV55_RS16835 ENOG4105C44 Serine transporter BHV55_RS16865 ENOG4108TZY GntR Family Transcriptional Regulator BHV55_RS16870 ENOG4105D9R oxidoreductase BHV55_RS16910 ENOG4105JAB phenazine biosynthesis protein, phzf family BHV55_RS16920 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BHV55_RS16925 ENOG4105KVH Transcriptional regulator BHV55_RS16995 ENOG4105KAF membrAne BHV55_RS17040 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BHV55_RS17135 ENOG4108TN2 lmbE family BHV55_RS17145 ENOG4107R3E Citrate transporter BHV55_RS17160 ENOG4108MES Periplasmic binding protein BHV55_RS17165 ENOG4105EHG Permease protein BHV55_RS17170 ENOG4105DQ5 transport system permease protein BHV55_RS17175 ENOG4105NX3 Membrane BHV55_RS17195 ENOG41068WN BHV55_RS17200 ENOG4107CUJ Protein of unknown function (DUF2690) BHV55_RS17210 ENOG4107V2S Transcriptional regulator BHV55_RS17220 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BHV55_RS17235 ENOG4105C98 muts2 protein BHV55_RS17240 ENOG4105E5K Alpha-amylase BHV55_RS17245 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BHV55_RS17250 ENOG4105DPN Oligoendopeptidase f BHV55_RS17280 ENOG4108A04 Beta-lactamase BHV55_RS17305 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BHV55_RS17315 ENOG41082BM Transcriptional regulator, arsr family BHV55_RS17320 ENOG4105CIS alcohol dehydrogenase BHV55_RS17345 ENOG4105RHY Pfam:UPF0157 BHV55_RS17360 ENOG4105CQB FAD linked oxidase domain protein BHV55_RS17385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BHV55_RS17390 ENOG4107TPS domain protein BHV55_RS17395 ENOG4105CEP NADH dehydrogenase BHV55_RS17405 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BHV55_RS17415 ENOG4108IAJ Nad-dependent epimerase dehydratase BHV55_RS17420 ENOG4105FAW cDP-glucose 4,6-dehydratase BHV55_RS17470 ENOG4105BZU Histidine kinase BHV55_RS17475 ENOG4105C5H ABC transporter BHV55_RS17485 ENOG4107DUR UPF0457 protein BHV55_RS17505 ENOG4105BZU Histidine kinase BHV55_RS17515 ENOG4105KT7 mgtC SapB transporter BHV55_RS17525 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BHV55_RS17530 ENOG41073R8 VanW family BHV55_RS17540 ENOG4108R1P BHV55_RS17555 ENOG4105VEQ Cold shock protein BHV55_RS17580 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BHV55_RS17600 ENOG410904N short-chain dehydrogenase reductase BHV55_RS17610 ENOG4106IQC argininosuccinate lyase BHV55_RS17625 ENOG4108IA2 Sodium pantothenate symporter BHV55_RS17635 ENOG4105C26 Dehydrogenase BHV55_RS17640 ENOG4105CHR reductase BHV55_RS17650 ENOG4105EWU Squalene--hopene cyclase BHV55_RS17660 ENOG4105FR1 rard protein BHV55_RS17665 ENOG410696E Membrane BHV55_RS17680 ENOG4105D1F ATP-binding protein BHV55_RS17690 ENOG4108ZAF Molybdopterin BHV55_RS17695 ENOG4105CVM Molybdenum cofactor synthesis domain protein BHV55_RS17700 ENOG4105D06 uba thif-type nad fad binding protein BHV55_RS17705 ENOG4105TMB Formate nitrite transporter BHV55_RS17715 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BHV55_RS17720 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BHV55_RS17730 ENOG4108JB9 formate dehydrogenase BHV55_RS17735 ENOG4105E1K spore germination protein BHV55_RS17750 ENOG4105CUB amino acid BHV55_RS17805 ENOG4108KGH TRANSCRIPTIONal BHV55_RS17815 ENOG4105EMN RNA polymerase sigma factor BHV55_RS17825 ENOG4105CIG ABC transporter BHV55_RS17845 ENOG4105D9R oxidoreductase BHV55_RS17855 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BHV55_RS17860 ENOG4105K4P CoA-binding domain protein BHV55_RS17865 ENOG4105C0H protease BHV55_RS17870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS17880 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BHV55_RS17890 ENOG4105W8X HesB YadR YfhF-family protein BHV55_RS17920 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BHV55_RS17925 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BHV55_RS17945 ENOG4108I0Z Aconitate hydratase BHV55_RS17975 ENOG4105E5W Transporter BHV55_RS17985 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BHV55_RS18005 ENOG4107F3J Amp-dependent synthetase and ligase BHV55_RS18010 ENOG4107ZYJ bioY protein BHV55_RS18015 ENOG4105CEY Amp-dependent synthetase and ligase BHV55_RS18020 ENOG4108IMY Transcriptional regulator BHV55_RS18045 ENOG4105D9G High-affinity BHV55_RS18050 ENOG4105IW1 AmiS UreI transporter BHV55_RS18065 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BHV55_RS18105 ENOG4107AYK membrAne BHV55_RS18115 ENOG4105BZU Histidine kinase BHV55_RS18120 ENOG4105FBA Phospholipase Carboxylesterase BHV55_RS18125 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BHV55_RS18135 ENOG4105CBC glutamate synthase BHV55_RS18140 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BHV55_RS18145 ENOG4108VJ1 Transcriptional regulator (CarD family BHV55_RS18150 ENOG4108903 Formimidoylglutamase BHV55_RS18160 ENOG4105CGP Urocanate hydratase BHV55_RS18175 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BHV55_RS18220 ENOG4107QIV Cytochrome c biogenesis protein BHV55_RS18240 ENOG4105CJ1 ABC, transporter BHV55_RS18255 ENOG4107RSM transcriptional regulator BHV55_RS18265 ENOG41067MG lrgb family BHV55_RS18305 ENOG4105BZ1 (ABC) transporter BHV55_RS18310 ENOG4105BZ1 (ABC) transporter BHV55_RS18345 ENOG4108HW3 (ABC) transporter BHV55_RS18350 ENOG4105CGH 5'-nucleotidase BHV55_RS18360 ENOG4108SVB resolvase BHV55_RS18380 ENOG4105K7K Transcriptional regulator BHV55_RS18395 ENOG4105E4C Lytic transglycosylase catalytic BHV55_RS18435 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BHV55_RS18440 ENOG4105C5F glutamine synthetase BHV55_RS18445 ENOG4105KV4 Transcriptional regulator BHV55_RS18450 ENOG4105CXI aluminum resistance protein BHV55_RS18455 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BHV55_RS18460 ENOG4105EN6 Membrane BHV55_RS18470 ENOG4106F1P AAA ATPase, central domain protein BHV55_RS18540 ENOG4105CGH 5'-nucleotidase BHV55_RS18555 ENOG4105CEY Amp-dependent synthetase and ligase BHV55_RS18560 ENOG4108S0S Nucleotidyl transferase BHV55_RS18565 ENOG4107STF Involved in phosphonate degradation (By similarity) BHV55_RS18570 ENOG41081VB Hydrolase BHV55_RS18590 ENOG4105DHF Membrane BHV55_RS18635 ENOG41069ER domain protein BHV55_RS18640 ENOG4105DM4 PTS System BHV55_RS18645 ENOG4105DE4 1-phosphofructokinase BHV55_RS18650 ENOG4105E98 transcriptional regulator DeoR family BHV55_RS18655 ENOG4107QW4 alcohol dehydrogenase BHV55_RS18660 ENOG4108SJC Membrane BHV55_RS18670 ENOG4105C85 amino acid BHV55_RS18685 ENOG4105TMB Formate nitrite transporter BHV55_RS18690 ENOG4105K70 DNA-binding protein BHV55_RS18700 ENOG4105C59 p-type ATPase BHV55_RS18705 ENOG410681U heavy metal transport detoxification protein BHV55_RS18710 ENOG4105VPX protein, conserved in bacteria BHV55_RS18720 ENOG4105NIV Esterase BHV55_RS18725 ENOG4105E0A ABC, transporter BHV55_RS18755 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BHV55_RS18760 ENOG4105D03 DNA-3-methyladenine glycosylase II BHV55_RS18785 ENOG4105BZU Histidine kinase BHV55_RS18805 ENOG4105C5E polysaccharide biosynthesis protein BHV55_RS18825 ENOG41067MG lrgb family BHV55_RS18845 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BHV55_RS18855 ENOG4105F0V Cell wall hydrolase BHV55_RS18865 ENOG4105E0M Sulfatase BHV55_RS18870 ENOG410890F Dynamin family BHV55_RS18905 ENOG4105DQU oxidoreductase, subunit beta BHV55_RS18910 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BHV55_RS18915 ENOG4108IGT Dipeptidase BHV55_RS18920 ENOG4105MCT stage V sporulation protein S BHV55_RS18925 ENOG4105D48 metallophosphoesterase BHV55_RS18950 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BHV55_RS18965 ENOG4105XZV Protein of unknown function (DUF3243) BHV55_RS18970 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BHV55_RS18990 ENOG4105UIB (ABC) transporter BHV55_RS18995 ENOG4108JQ9 ABC transporter BHV55_RS19000 ENOG4105DIH basic membrane BHV55_RS19005 ENOG4105FDP GntR family transcriptional regulator BHV55_RS19015 ENOG4105CNU cell division protein FtsK BHV55_RS19025 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BHV55_RS19035 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BHV55_RS19045 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BHV55_RS19050 ENOG4108S0H Dipicolinic acid synthetase, b subunit BHV55_RS19055 ENOG4105E35 Dipicolinate synthase subunit A BHV55_RS19065 ENOG4105C1V Peptidase, M16 BHV55_RS19085 ENOG4105DTN riboflavin biosynthesis protein ribF BHV55_RS19100 ENOG4105W7A Protein of unknown function (DUF503) BHV55_RS19110 ENOG4105VHM ribosomal protein BHV55_RS19115 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BHV55_RS19120 ENOG4105CHV Transcription elongation factor NusA BHV55_RS19130 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BHV55_RS19140 ENOG4105DZP Membrane-associated zinc metalloprotease BHV55_RS19145 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BHV55_RS19150 ENOG4105KNE Phosphatidate cytidylyltransferase BHV55_RS19155 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BHV55_RS19165 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BHV55_RS19195 ENOG4108HE4 integrase family BHV55_RS19205 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BHV55_RS19210 ENOG4105C79 DNA protecting protein DprA BHV55_RS19215 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BHV55_RS19230 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BHV55_RS19255 ENOG4105VB6 UPF0109 protein BHV55_RS19275 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BHV55_RS19280 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BHV55_RS19295 ENOG4105CHR reductase BHV55_RS19300 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BHV55_RS19315 ENOG4105CB5 ATP-dependent DNA helicase recG BHV55_RS19320 ENOG4105DP4 dak2 domain fusion protein ylov BHV55_RS19325 ENOG4108ZAA Alkaline-shock protein BHV55_RS19340 ENOG4105FJ0 thiamine BHV55_RS19345 ENOG4105DJV ribulose-phosphate 3-epimerase BHV55_RS19350 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BHV55_RS19355 ENOG4105D9P serine threonine protein kinase BHV55_RS19360 ENOG4108ZF3 Phosphatase BHV55_RS19370 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BHV55_RS19385 ENOG4105C25 Primosomal protein n' BHV55_RS19390 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BHV55_RS19410 ENOG4105DSJ YicC domain protein BHV55_RS19430 ENOG4105DC7 peptidase M24 BHV55_RS19475 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BHV55_RS19480 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BHV55_RS19490 ENOG4105CD3 dihydroorotase BHV55_RS19510 ENOG4105C34 Pseudouridine synthase BHV55_RS19535 ENOG4105DBK s4 domain protein BHV55_RS19540 ENOG41067XK integral membrane protein BHV55_RS19550 ENOG4105DFA alanine racemase domain protein BHV55_RS19555 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BHV55_RS19560 ENOG4105WR5 sporulation protein, YlmC YmxH family BHV55_RS19570 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHV55_RS19580 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BHV55_RS19585 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BHV55_RS19595 ENOG4105D4A Cell wall formation (By similarity) BHV55_RS19600 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BHV55_RS19605 ENOG4105CNI cell division protein FtsW BHV55_RS19620 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BHV55_RS19625 ENOG4105CJN penicillin-binding protein BHV55_RS19630 ENOG4105CJN penicillin-binding protein BHV55_RS19645 ENOG41074B2 UPF0747 protein BHV55_RS19670 ENOG4105KNH Nucleic acid-binding protein BHV55_RS19680 ENOG41063PX domain protein BHV55_RS19685 ENOG4105D78 K07001 NTE family protein BHV55_RS19690 ENOG4105H20 Sporulation integral membrane protein YlbJ BHV55_RS19700 ENOG4106H78 methyltransferase BHV55_RS19720 ENOG4107TB6 phosphoglycerate mutase BHV55_RS19735 ENOG4106UY4 Inherit from COG: Scp-like extracellular BHV55_RS19785 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BHV55_RS19790 ENOG4105CNI cell division protein FtsW BHV55_RS19805 ENOG4108IAB Phoh family BHV55_RS19825 ENOG4105QA2 BHV55_RS19830 ENOG4105CI3 gtp-binding protein typa BHV55_RS19840 ENOG4105ECY inositol monophosphatase BHV55_RS19860 ENOG4105CXN decarboxylase BHV55_RS19910 ENOG4105CPP Dehydrogenase, E1 component BHV55_RS19925 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BHV55_RS19930 ENOG4108X4Q Hydrolase BHV55_RS19940 ENOG4105CN5 Metallo-Beta-Lactamase BHV55_RS19945 ENOG4107ZYR domain protein BHV55_RS19980 ENOG4108XRC Protein of unknown function (DUF458) BHV55_RS19990 ENOG4107IN1 Protein of unknown function (DUF1797) BHV55_RS20005 ENOG4105EPM Diguanylate phosphodiesterase BHV55_RS20010 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BHV55_RS20025 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BHV55_RS20035 ENOG4105UIN BHV55_RS20070 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BHV55_RS20090 ENOG4108HGU Histidine kinase BHV55_RS20100 ENOG4105CHM Aminotransferase BHV55_RS20105 ENOG4105FKQ transcriptional regulator BHV55_RS20110 ENOG4105EG2 ABC transporter, permease BHV55_RS20120 ENOG4107FKK extracellular solute-binding protein family 1 BHV55_RS20130 ENOG4105CG3 alpha amylase, catalytic region BHV55_RS20175 ENOG4105CHU acetyl-coa acetyltransferase BHV55_RS20210 ENOG4105K7K Transcriptional regulator BHV55_RS20215 ENOG4105DTD Dehydrogenase BHV55_RS20235 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BHV55_RS20260 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BHV55_RS20275 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BHV55_RS20285 ENOG4105BZU Histidine kinase BHV55_RS20305 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BHV55_RS20320 ENOG4105CID antiterminator BHV55_RS20340 ENOG4105CE4 GlcNAc 6-P deacetylase BHV55_RS20375 ENOG4107ZE5 PPIases accelerate the folding of proteins BHV55_RS20380 ENOG4105PTM secreted protein BHV55_RS20385 ENOG4105J7I hydrolase BHV55_RS20395 ENOG4105G6R Stage v sporulation protein ae BHV55_RS20405 ENOG4105CZ3 stage V sporulation protein ad BHV55_RS20410 ENOG41090VF Stage v sporulation protein ac BHV55_RS20430 ENOG4105C8J )-transporter BHV55_RS20435 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHV55_RS20445 ENOG41082AN stage II sporulation protein BHV55_RS20450 ENOG4105DZ1 carboxypeptidase BHV55_RS20455 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BHV55_RS20460 ENOG4105DVE abc transporter atp-binding protein BHV55_RS20490 ENOG4105D7N magnesium and cobalt transport protein CorA BHV55_RS20515 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BHV55_RS20525 ENOG4105I3K Ferric uptake regulator, Fur family BHV55_RS20530 ENOG4105MZ9 stage II sporulation protein m BHV55_RS20550 ENOG4105CPC Aldo Keto reductase BHV55_RS20560 ENOG4105RHY Pfam:UPF0157 BHV55_RS20580 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BHV55_RS20590 ENOG4105ETE Transcriptional regulator (LacI family BHV55_RS20595 ENOG4108YM7 Gcn5-related n-acetyltransferase BHV55_RS20615 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BHV55_RS20620 ENOG4108R6K riboflavin synthase, subunit alpha BHV55_RS20645 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BHV55_RS20650 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BHV55_RS20665 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BHV55_RS20675 ENOG4105DFD Na H antiporter BHV55_RS20680 ENOG4105CGH 5'-nucleotidase BHV55_RS20705 ENOG4105DBV ornithine carbamoyltransferase BHV55_RS20720 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BHV55_RS20735 ENOG4108IXY short-chain dehydrogenase reductase BHV55_RS20740 ENOG41069FQ Metallo-beta-lactamase superfamily BHV55_RS20745 ENOG4105II7 pyrroline-5-carboxylate reductase BHV55_RS20750 ENOG4105EJQ L-serine dehydratase BHV55_RS20765 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BHV55_RS20780 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BHV55_RS20795 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BHV55_RS20800 ENOG4105D9U N-acetyltransferase BHV55_RS20815 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BHV55_RS20820 ENOG4108QEG Membrane BHV55_RS20825 ENOG4105CDA abc transporter atp-binding protein BHV55_RS20830 ENOG4105E5Q amino acid AbC transporter BHV55_RS20835 ENOG4108HW3 (ABC) transporter BHV55_RS20845 ENOG4105G7B Protein of unknown function (DUF2992) BHV55_RS20855 ENOG4108QY0 Membrane BHV55_RS20865 ENOG4105C7S Dehydrogenase BHV55_RS20870 ENOG4105CPP Dehydrogenase, E1 component BHV55_RS20890 ENOG4107RDP Dehydrogenase BHV55_RS20900 ENOG4108JUB Transcriptional regulator BHV55_RS20910 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BHV55_RS20925 ENOG4107QQR Sporulation BHV55_RS20930 ENOG4105S1Z Stage IV sporulation protein B BHV55_RS20935 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BHV55_RS20940 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BHV55_RS20945 ENOG4105DX0 Hemolysin A BHV55_RS20955 ENOG4105CTB Polyprenyl synthetase BHV55_RS20970 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BHV55_RS20980 ENOG4108ZSR alkaline shock protein BHV55_RS20985 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BHV55_RS21010 ENOG410644B Stage III sporulation protein af BHV55_RS21020 ENOG4105KQ4 Stage iii sporulation protein ad BHV55_RS21025 ENOG4108CQH stage III sporulation protein AC BHV55_RS21030 ENOG4105KR5 Stage iii sporulation protein BHV55_RS21035 ENOG4105CD2 stage iii sporulation protein aa BHV55_RS21060 ENOG4105DC7 peptidase M24 BHV55_RS21065 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BHV55_RS21075 ENOG4105CBJ Metal-dependent enzyme BHV55_RS21085 ENOG4107YBY Hydrolase BHV55_RS21115 ENOG41082GG biotin lipoate A B protein ligase BHV55_RS21120 ENOG4105WZW rhodanese family BHV55_RS21145 ENOG41080TC multidrug resistance protein BHV55_RS21175 ENOG4105CJ1 ABC, transporter BHV55_RS21180 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BHV55_RS21210 ENOG4105C0D helicase BHV55_RS21330 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BHV55_RS21335 ENOG4105C3R Methionine synthase BHV55_RS21345 ENOG4105C28 cystathionine BHV55_RS21350 ENOG4105C28 cystathionine BHV55_RS21370 ENOG4105C5X domain protein BHV55_RS21380 ENOG4105DKQ ROK family BHV55_RS21390 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BHV55_RS21405 ENOG4108UTW Plays a role in the regulation of phosphate uptake BHV55_RS21410 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BHV55_RS21415 ENOG4105C8U phosphate abc transporter BHV55_RS21420 ENOG4105C8U phosphate abc transporter BHV55_RS21425 ENOG4105EXS phosphate abc transporter BHV55_RS21430 ENOG4107RF6 penicillin-binding protein BHV55_RS21440 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BHV55_RS21465 ENOG4105N80 Ferric uptake regulator, Fur family BHV55_RS21475 ENOG4105FDK ABC transporter BHV55_RS21480 ENOG4108JYZ YitT family BHV55_RS21485 ENOG41069ZM Protein of unknown function (DUF2624) BHV55_RS21510 ENOG4105EGD dinuclear metal center protein, YbgI family BHV55_RS21525 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHV55_RS21530 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BHV55_RS21555 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BHV55_RS21560 ENOG4105KG3 cytidine deaminase BHV55_RS21565 ENOG4107YR5 Diacylglycerol kinase BHV55_RS21575 ENOG4105CTJ Metal Dependent Phosphohydrolase BHV55_RS21580 ENOG4105C9A Phoh family BHV55_RS21590 ENOG41068P3 sporulation protein YqfC BHV55_RS21595 ENOG4105KTH gatB Yqey BHV55_RS21605 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BHV55_RS21610 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BHV55_RS21640 ENOG4105CSA Coproporphyrinogen iii oxidase BHV55_RS21645 ENOG4105KVH Transcriptional regulator BHV55_RS21670 ENOG4105TQK DNA polymerase iii, delta' subunit BHV55_RS21680 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BHV55_RS21685 ENOG4108UK2 deaminase BHV55_RS21690 ENOG4105KQC Competence protein BHV55_RS21700 ENOG4105DXX methyltransferase BHV55_RS21710 ENOG4108WF2 Metal Dependent Phosphohydrolase BHV55_RS21720 ENOG410812S Rna-binding protein BHV55_RS21730 ENOG4105CQW ribosome biogenesis GTPase YqeH BHV55_RS21735 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BHV55_RS21750 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHV55_RS21770 ENOG4108TVJ Nitroreductase BHV55_RS21785 ENOG4105G6Z alkaline phosphatase BHV55_RS21790 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BHV55_RS21795 ENOG4108MUZ hydrolase BHV55_RS21830 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BHV55_RS21835 ENOG4105MIR Phenylalanine 4-monooxygenase BHV55_RS21845 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BHV55_RS21885 ENOG4105S6R Iron-hydroxamate transporter permease subunit BHV55_RS21890 ENOG4108V5C ABC transporter BHV55_RS21900 ENOG4105C0A alcohol dehydrogenase BHV55_RS21905 ENOG4105C28 cystathionine BHV55_RS21935 ENOG4107XRG penicillin-binding protein BHV55_RS21945 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BHV55_RS21955 ENOG4105CFP Peptidase U32 BHV55_RS21960 ENOG4105XYU peptidase (U32 family) BHV55_RS21970 ENOG4105HHA aminodeoxychorismate lyase BHV55_RS21990 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BHV55_RS22000 ENOG4105C02 permease BHV55_RS22015 ENOG41060CR BHV55_RS22020 ENOG4105C7H Helicase, RecD TraA family BHV55_RS22030 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BHV55_RS22035 ENOG4105C3J Cysteine desulfurase BHV55_RS22045 ENOG4105D1H recombination factor protein RarA BHV55_RS22050 ENOG4108VCI transcription factor, rsfa family BHV55_RS22055 ENOG4105CUZ uba thif-type nad fad binding protein BHV55_RS22065 ENOG4105CUT histidyl-tRNA synthetase BHV55_RS22075 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BHV55_RS22080 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BHV55_RS22090 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BHV55_RS22095 ENOG41076HS cation diffusion facilitator family transporter BHV55_RS22100 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BHV55_RS22110 ENOG4105CKP Polysaccharide Biosynthesis Protein BHV55_RS22115 ENOG4108QG2 Membrane BHV55_RS22125 ENOG4105VIE preprotein translocase, subunit YajC BHV55_RS22140 ENOG41061AI Protein of unknown function (DUF2905) BHV55_RS22155 ENOG4108HUF Transporter BHV55_RS22165 ENOG4108IPJ Membrane BHV55_RS22170 ENOG41082BM Transcriptional regulator, arsr family BHV55_RS22195 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BHV55_RS22200 ENOG4108IYU L-aspartate oxidase BHV55_RS22215 ENOG4108RPX mosc domain containing protein BHV55_RS22225 ENOG4105CQC Prephenate dehydratase BHV55_RS22240 ENOG4105C19 ABC transporter BHV55_RS22245 ENOG4105EWM Histidine kinase BHV55_RS22255 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BHV55_RS22275 ENOG4105C03 ribonuclease BHV55_RS22290 ENOG4107QMS site-determining protein BHV55_RS22310 ENOG4105DFF Rod shape-determining protein mreb BHV55_RS22330 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BHV55_RS22335 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BHV55_RS22345 ENOG41068KH stage VI sporulation protein D BHV55_RS22355 ENOG4105D52 delta-aminolevulinic acid dehydratase BHV55_RS22380 ENOG4105K56 Transcriptional regulator BHV55_RS22400 ENOG4108IUQ atp-dependent protease BHV55_RS22425 ENOG4108QCI YvbH-like oligomerisation region BHV55_RS22445 ENOG4105M59 Phosphodiesterase, mj0936 family BHV55_RS22460 ENOG4108XJQ germination protein BHV55_RS22475 ENOG4105PFC Transcriptional regulator BHV55_RS22485 ENOG4105DZC cytosine deaminase BHV55_RS22490 ENOG41067S9 phage shock protein C, PspC BHV55_RS22495 ENOG4108JCI Transcriptional regulator BHV55_RS22505 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BHV55_RS22510 ENOG4108Z40 Transcriptional regulator BHV55_RS22515 ENOG4105RHA ABC transporter, permease BHV55_RS22520 ENOG4108IUX (ABC) transporter BHV55_RS22525 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BHV55_RS22530 ENOG4105ER2 Ompa motb domain protein BHV55_RS22535 ENOG4105E14 MotA TolQ exbB proton channel BHV55_RS22540 ENOG4108VXD carboxy-peptidase BHV55_RS22550 ENOG4105E33 succinate dehydrogenase BHV55_RS22560 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BHV55_RS22570 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BHV55_RS22575 ENOG4105K63 Thioredoxin BHV55_RS22580 ENOG4105C10 Electron transfer flavoprotein BHV55_RS22585 ENOG4105BZJ Electron transfer flavoprotein BHV55_RS22590 ENOG41060WC Enoyl-CoA hydratase BHV55_RS22595 ENOG4107Z3H Transcriptional regulator, TetR family BHV55_RS22600 ENOG4105CEY Amp-dependent synthetase and ligase BHV55_RS22660 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHV55_RS22675 ENOG4105DR4 Methyltransferase BHV55_RS22685 ENOG4105KFN sortase, SrtB family BHV55_RS22690 ENOG4105E0A ABC, transporter BHV55_RS22705 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BHV55_RS22715 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BHV55_RS22725 ENOG4105FE9 pseudouridine synthase BHV55_RS22735 ENOG4105DCG PHP domain protein BHV55_RS22750 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BHV55_RS22770 ENOG4105C5S asparaginyl-tRNA synthetase BHV55_RS22775 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BHV55_RS22785 ENOG4108RWN rrna methyltransferase BHV55_RS22815 ENOG4105C0R drug resistance transporter emrb qaca subfamily BHV55_RS22820 ENOG4105CW7 secretion protein, HlyD family BHV55_RS22825 ENOG4108JGH Tetr family transcriptional regulator BHV55_RS22830 ENOG4105CN9 Peptidase m42 family protein BHV55_RS22850 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BHV55_RS22855 ENOG4105C22 threonyL-tRNA synthetase BHV55_RS22860 ENOG4108TDW sporulation protein YtxC BHV55_RS22890 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BHV55_RS22895 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BHV55_RS22905 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BHV55_RS22910 ENOG4105C2M dna polymerase I BHV55_RS22915 ENOG4105BZU Histidine kinase BHV55_RS22920 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHV55_RS22940 ENOG4108HMX isocitrate dehydrogenase (NADP) BHV55_RS22945 ENOG4105BZN citrate synthase BHV55_RS22955 ENOG4108REF Sporulation integral membrane protein ytvi BHV55_RS22960 ENOG4105FS0 cytoplasmic membrane protein BHV55_RS22985 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BHV55_RS22990 ENOG4105C6K Malic enzyme BHV55_RS23000 ENOG4105VV2 BHV55_RS23010 ENOG4105SFS phosphoesterase RecJ domain protein BHV55_RS23035 ENOG4105E8R UPF0173 metal-dependent hydrolase BHV55_RS23040 ENOG4105DC7 peptidase M24 BHV55_RS23075 ENOG41082W1 Cupin 2, conserved barrel domain protein BHV55_RS23095 ENOG4107YZX Universal stress protein BHV55_RS23130 ENOG4108JYZ YitT family BHV55_RS23150 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BHV55_RS23160 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BHV55_RS23165 ENOG4105KBJ sporulation protein ytfj BHV55_RS23180 ENOG4105EFZ amidohydrolase BHV55_RS23190 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BHV55_RS23215 ENOG4105RQF LysR family Transcriptional regulator BHV55_RS23225 ENOG4105U5Y Transcriptional regulator BHV55_RS23235 ENOG4105C28 cystathionine BHV55_RS23280 ENOG4108UW5 maltose o-acetyltransferase BHV55_RS23290 ENOG4105F1V Acetoin utilization protein BHV55_RS23295 ENOG4105W87 Cbs domain BHV55_RS23300 ENOG4105DGU Histone deacetylase BHV55_RS23315 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHV55_RS23320 ENOG4105BZU Histidine kinase BHV55_RS23325 ENOG4107SNB ankyrin repeat protein YahD BHV55_RS23330 ENOG4105EP9 oxidoreductase BHV55_RS23350 ENOG4105ETE Transcriptional regulator (LacI family BHV55_RS23355 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BHV55_RS23375 ENOG4105C88 aminopeptidase BHV55_RS23395 ENOG4108IPJ Membrane BHV55_RS23420 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BHV55_RS23430 ENOG4108VDD TRNA binding domain protein BHV55_RS23460 ENOG4105C8F Beta-lactamase domain protein BHV55_RS23475 ENOG4108V15 phosphotransferase enzyme family BHV55_RS23480 ENOG4108IUM Glycogen debranching enzyme BHV55_RS23490 ENOG4107QSE Dipeptidase BHV55_RS23495 ENOG4105YW5 deoR family transcriptional regulator BHV55_RS23510 ENOG4105CBX hi0933 family BHV55_RS23545 ENOG4108VJ1 Transcriptional regulator (CarD family BHV55_RS23550 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BHV55_RS23555 ENOG4105CSC Glucose uptake protein BHV55_RS23570 ENOG4108ZAF Molybdopterin BHV55_RS23575 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BHV55_RS23580 ENOG4105CVM Molybdenum cofactor synthesis domain protein BHV55_RS23590 ENOG4105D06 uba thif-type nad fad binding protein BHV55_RS23595 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BHV55_RS23615 ENOG41085GJ domain protein BHV55_RS23625 ENOG4105DWV Homoserine O-trans-acetylase BHV55_RS23635 ENOG4108B31 Spore germination protein BHV55_RS23665 ENOG4105C8T Leucyl-tRNA synthetase BHV55_RS23670 ENOG410605W Major Facilitator BHV55_RS23675 ENOG4107S91 Sodium hydrogen exchanger BHV55_RS23680 ENOG4105NCW Trka-c domain protein BHV55_RS23695 ENOG4105C19 ABC transporter BHV55_RS23715 ENOG4105N5T Radical SAM Protein BHV55_RS23735 ENOG4107A6P BHV55_RS23755 ENOG4105E8V Alpha Beta Hydrolase Fold protein BHV55_RS23760 ENOG4108Z0R Transferase BHV55_RS23765 ENOG4105YVM Phosphoesterase, PA-phosphatase related BHV55_RS23770 ENOG4105BZF Glycosyl transferase (Group 1 BHV55_RS23780 ENOG4105EPU Molybdenum cofactor synthesis domain protein BHV55_RS23795 ENOG4108MK9 spermidine N(1)-acetyltransferase BHV55_RS23835 ENOG4105BZU Histidine kinase BHV55_RS23840 ENOG4105BZU Histidine kinase BHV55_RS23845 ENOG4107S9D Alpha beta hydrolase BHV55_RS23850 ENOG4107T7U Sulfatase BHV55_RS23865 ENOG4105D2X ABC transporter substrate-binding protein BHV55_RS23875 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BHV55_RS23940 ENOG4108V2W Carbonate dehydratase BHV55_RS23945 ENOG4105C4M (Ubiquinol oxidase) subunit I BHV55_RS23950 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BHV55_RS23985 ENOG41087YS Phage shock protein A BHV55_RS24015 ENOG4105BZU Histidine kinase BHV55_RS24020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS24045 ENOG4108UGV hypoxanthine phosphoribosyltransferase BHV55_RS24050 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BHV55_RS24085 ENOG4107ZTW SNARE associated Golgi BHV55_RS24100 ENOG4105C19 ABC transporter BHV55_RS24105 ENOG41086D8 Transcriptional regulator BHV55_RS24120 ENOG41082BM Transcriptional regulator, arsr family BHV55_RS24170 ENOG4105C6Z Gluconate BHV55_RS24175 ENOG4105FDP GntR family transcriptional regulator BHV55_RS24195 ENOG41069H0 dihydroorotase EC 3.5.2.3 BHV55_RS24225 ENOG4105DTQ mandelate racemase muconate lactonizing BHV55_RS24235 ENOG4108IPT Naphthoate synthase BHV55_RS24240 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BHV55_RS24250 ENOG4105E4F Isochorismate synthase BHV55_RS24255 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BHV55_RS24265 ENOG4105VEQ Cold shock protein BHV55_RS24300 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BHV55_RS24415 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BHV55_RS24450 ENOG4105KT7 mgtC SapB transporter BHV55_RS24455 ENOG4107PBV potassium channel BHV55_RS24470 ENOG4105WG9 Conserved Protein BHV55_RS24480 ENOG4105CHM Aminotransferase BHV55_RS24485 ENOG4108ZB6 transcriptional regulator AsnC family BHV55_RS24490 ENOG4105C5I Dehydrogenase BHV55_RS24495 ENOG4108MUZ hydrolase BHV55_RS24505 ENOG4105C87 Aminotransferase class I and II BHV55_RS24520 ENOG4105Y38 Kinase-associated protein B BHV55_RS24530 ENOG4107R3E Citrate transporter BHV55_RS24550 ENOG4105KA0 thioesterase Superfamily protein BHV55_RS24565 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BHV55_RS24585 ENOG41069ER domain protein BHV55_RS24600 ENOG4105CEP NADH dehydrogenase BHV55_RS24630 ENOG4105EWC Purine nucleoside phosphorylase BHV55_RS24645 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BHV55_RS24670 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BHV55_RS24675 ENOG4105C4B ABC transporter, permease BHV55_RS24680 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BHV55_RS24735 ENOG41083MR nifu domain-containing protein BHV55_RS24750 ENOG4108W5N phosphatidylglycerophosphatase a BHV55_RS24770 ENOG4105DAX Pfam:DUF2983 BHV55_RS24780 ENOG4105DYS nad(p)h dehydrogenase (quinone) BHV55_RS24790 ENOG4105D4U had-superfamily hydrolase, subfamily iia BHV55_RS24805 ENOG4105CBT Fructose-1,6-bisphosphatase BHV55_RS24820 ENOG4105MMD transcriptional regulator BHV55_RS24825 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BHV55_RS24830 ENOG4107TXC Transcriptional regulator BHV55_RS24835 ENOG41090T1 Membrane BHV55_RS24860 ENOG4105FAA peptidase M23 BHV55_RS24865 ENOG4108YTE sporulation protein YunB BHV55_RS24870 ENOG4105KZD Domain of unknown function (DUF1805) BHV55_RS24875 ENOG4107R8B 5'-nucleotidase BHV55_RS24880 ENOG4105DIW FeS assembly protein SUFB BHV55_RS24885 ENOG4108UNV SUF system FeS assembly protein, NifU family BHV55_RS24890 ENOG4105C9B Cysteine desulfurase BHV55_RS24895 ENOG4105JRK feS assembly protein SufD BHV55_RS24900 ENOG4105C3K feS assembly ATPase SufC BHV55_RS24905 ENOG4105D01 (LipO)protein BHV55_RS24910 ENOG4105D01 (LipO)protein BHV55_RS24915 ENOG4108UMI ABC transporter, permease BHV55_RS24920 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BHV55_RS24945 ENOG41080E8 Transcriptional regulator, Spx MgsR family BHV55_RS24965 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BHV55_RS24985 ENOG4108W8B Beta-lactamase domain protein BHV55_RS24990 ENOG4105C1G acyl-Coa dehydrogenase BHV55_RS24995 ENOG4105CHU acetyl-coa acetyltransferase BHV55_RS25010 ENOG4105DZ1 carboxypeptidase BHV55_RS25030 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BHV55_RS25045 ENOG4108SUT Major Facilitator Superfamily BHV55_RS25050 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BHV55_RS25060 ENOG4107R7I amino acid BHV55_RS25085 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BHV55_RS25095 ENOG4107AYK membrAne BHV55_RS25130 ENOG4107ZTW SNARE associated Golgi BHV55_RS25140 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BHV55_RS25145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS25150 ENOG4105BZU Histidine kinase BHV55_RS25165 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BHV55_RS25180 ENOG4105C8Q Methyl-accepting chemotaxis BHV55_RS25185 ENOG4105VG1 fes assembly suf system protein BHV55_RS25190 ENOG4105D4Y metalloprotease BHV55_RS25195 ENOG4105C2I pirin domain protein BHV55_RS25210 ENOG4107T5V SNARE associated Golgi BHV55_RS25215 ENOG4107S91 Sodium hydrogen exchanger BHV55_RS25220 ENOG4105NCW Trka-c domain protein BHV55_RS25235 ENOG4108RMU ferritin dps family protein BHV55_RS25250 ENOG4108URH decarboxylase BHV55_RS25260 ENOG41090A1 ferritin BHV55_RS25265 ENOG4105DHF Membrane BHV55_RS25270 ENOG4105D9N nucleoside BHV55_RS25275 ENOG4105D9N nucleoside BHV55_RS25290 ENOG4108RYK Nad-dependent epimerase dehydratase BHV55_RS25305 ENOG4105CV8 reductase BHV55_RS25310 ENOG4105F27 Major Facilitator BHV55_RS25315 ENOG4105KVH Transcriptional regulator BHV55_RS25330 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BHV55_RS25335 ENOG4105D4A Cell wall formation (By similarity) BHV55_RS25345 ENOG4105C8Q Methyl-accepting chemotaxis BHV55_RS25355 ENOG4105WMR Protein CrcB homolog BHV55_RS25360 ENOG4105WMR Protein CrcB homolog BHV55_RS25380 ENOG4105C5H ABC transporter BHV55_RS25385 ENOG4108MK9 spermidine N(1)-acetyltransferase BHV55_RS25400 ENOG4108W2Y isochorismatase BHV55_RS25420 ENOG4108IPW abc transporter atp-binding protein BHV55_RS25425 ENOG4105CM4 permease protein BHV55_RS25440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS25460 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BHV55_RS25470 ENOG4105XZU Preprotein translocase, subunit SecG BHV55_RS25475 ENOG41067MG lrgb family BHV55_RS25525 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHV55_RS25535 ENOG4105RHA ABC transporter, permease BHV55_RS25540 ENOG4108IUX (ABC) transporter BHV55_RS25545 ENOG4105BZU Histidine kinase BHV55_RS25570 ENOG41090VF Stage v sporulation protein ac BHV55_RS25575 ENOG4105CZ3 stage V sporulation protein ad BHV55_RS25590 ENOG4108QY0 Membrane BHV55_RS25600 ENOG4105KRI phosphocarrier protein (HPr BHV55_RS25610 ENOG4105CHW UPF0052 protein BHV55_RS25620 ENOG4108Z4K mutator MutT protein BHV55_RS25630 ENOG4105C3M thioredoxin reductase BHV55_RS25640 ENOG4108S4C acetyltransferase BHV55_RS25660 ENOG41086DT Membrane protein of unknown function BHV55_RS25670 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BHV55_RS25675 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BHV55_RS25690 ENOG4107TXC Transcriptional regulator BHV55_RS25710 ENOG4105DUM transcriptional regulator, lysR family BHV55_RS25720 ENOG4108WS4 fmn reductase BHV55_RS25735 ENOG4105BZ1 (ABC) transporter BHV55_RS25745 ENOG4105CN1 protease BHV55_RS25750 ENOG4105CRP Part of the ABC transporter FtsEX involved in BHV55_RS25755 ENOG4105CAK Cell division ATP-binding protein ftsE BHV55_RS25780 ENOG4108RDQ ABC transporter BHV55_RS25810 ENOG4105MS2 ribosomal subunit Interface protein BHV55_RS25815 ENOG4105VEQ Cold shock protein BHV55_RS25820 ENOG41081UC Inherit from COG: Competence protein BHV55_RS25835 ENOG4105KVH Transcriptional regulator BHV55_RS25845 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BHV55_RS25850 ENOG4108KGH TRANSCRIPTIONal BHV55_RS25855 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BHV55_RS25860 ENOG4105C6Y Udp-glucose 6-dehydrogenase BHV55_RS25865 ENOG4105ESV Glycosyl transferase, family 4 BHV55_RS25875 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BHV55_RS25895 ENOG4105F8D glycoside hydrolase family 4 BHV55_RS25900 ENOG4105VCP PTS System BHV55_RS25905 ENOG4105CK1 PTS System BHV55_RS25915 ENOG4105VCP PTS System BHV55_RS25925 ENOG4105VZJ PTS System BHV55_RS25945 ENOG4105ECB domain protein BHV55_RS25950 ENOG4107RSM transcriptional regulator BHV55_RS25985 ENOG4105DAA L-lactate BHV55_RS25995 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BHV55_RS26005 ENOG4105E0M Sulfatase BHV55_RS26030 ENOG4107R8N Glycosyl transferase, family 2 BHV55_RS26035 ENOG4105C94 Transporter BHV55_RS26040 ENOG41069ER domain protein BHV55_RS26065 ENOG4105KBK Zinc finger, swim domain protein BHV55_RS26070 ENOG4105C0D helicase BHV55_RS26100 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHV55_RS26110 ENOG4107RBB ABC transporter, permease BHV55_RS26115 ENOG4105C19 ABC transporter BHV55_RS26135 ENOG4105CXY transporter BHV55_RS26150 ENOG4105BZU Histidine kinase BHV55_RS26155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS26165 ENOG4108KGH TRANSCRIPTIONal BHV55_RS26170 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BHV55_RS26180 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BHV55_RS26185 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BHV55_RS26195 ENOG4108PQP glycosyl transferase group 1 BHV55_RS26255 ENOG4105D3Q Sugar transferase BHV55_RS26260 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BHV55_RS26265 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BHV55_RS26270 ENOG4107YJ4 chain length determinant protein BHV55_RS26275 ENOG4105HTX biosynthesis protein BHV55_RS26280 ENOG4107YJ4 chain length determinant protein BHV55_RS26295 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BHV55_RS26305 ENOG4105FRN stage II sporulation protein BHV55_RS26320 ENOG4108IUW ABC transporter BHV55_RS26340 ENOG4106778 Protein of unknown function (DUF1146) BHV55_RS26345 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BHV55_RS26350 ENOG4105C8S subunit m BHV55_RS26355 ENOG4105D65 subunit l BHV55_RS26380 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BHV55_RS26385 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BHV55_RS26395 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BHV55_RS26400 ENOG4105BZU Histidine kinase BHV55_RS26450 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BHV55_RS26455 ENOG41062M3 atp synthase BHV55_RS26475 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BHV55_RS26480 ENOG4108UIC UPF0340 protein BHV55_RS26485 ENOG4108YZG isomerase BHV55_RS26500 ENOG4108VGI doxx family BHV55_RS26505 ENOG4107XC4 flavin reductase domain protein, FMN-binding BHV55_RS26520 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BHV55_RS26530 ENOG4108ZXQ stage ii sporulation protein r BHV55_RS26535 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BHV55_RS26540 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BHV55_RS26545 ENOG4107104 thymidine kinase BHV55_RS26555 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BHV55_RS26560 ENOG4105CBT Fructose-1,6-bisphosphatase BHV55_RS26565 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BHV55_RS26585 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BHV55_RS26600 ENOG4105C1G acyl-Coa dehydrogenase BHV55_RS26605 ENOG4105C1G acyl-Coa dehydrogenase BHV55_RS26610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BHV55_RS26620 ENOG4105DF6 Fe-S oxidoreductase BHV55_RS26635 ENOG4105BZU Histidine kinase BHV55_RS26650 ENOG4105D4Y metalloprotease BHV55_RS26660 ENOG4105BZU Histidine kinase BHV55_RS26665 ENOG4105KCT ABC transporter BHV55_RS26670 ENOG4108M15 ABC transporter BHV55_RS26675 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BHV55_RS26685 ENOG4105IIU Aminopeptidase BHV55_RS26710 ENOG4105EMN RNA polymerase sigma factor BHV55_RS26720 ENOG410684U Domain of unknown function (DUF1934) BHV55_RS26740 ENOG4105CYW agmatinase BHV55_RS26750 ENOG4105DXB Major Facilitator superfamily BHV55_RS26755 ENOG4107SWG transcriptional regulator MERR family BHV55_RS26760 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BHV55_RS26765 ENOG4105BZ4 penicillin-binding protein BHV55_RS26770 ENOG4108XFG YwhD family BHV55_RS26775 ENOG4108Z4T Peptidase M50 BHV55_RS26780 ENOG41069HH 4-oxalocrotonate tautomerase BHV55_RS26785 ENOG4105DCI Phosphohydrolase BHV55_RS26790 ENOG4108MES Periplasmic binding protein BHV55_RS26795 ENOG4105E0A ABC, transporter BHV55_RS26800 ENOG4105EHG Permease protein BHV55_RS26805 ENOG4105DQ5 transport system permease protein BHV55_RS26815 ENOG4108VCI transcription factor, rsfa family BHV55_RS26820 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BHV55_RS26825 ENOG4108IJ2 phosphate acetyltransferase BHV55_RS26840 ENOG4108VKI Cell wall hydrolase BHV55_RS26860 ENOG4107SVH Potassium channel protein BHV55_RS26870 ENOG410667J hydrolase BHV55_RS26875 ENOG4105VCH membrane BHV55_RS26885 ENOG4108TU7 Inherit from COG: (ABC) transporter BHV55_RS26890 ENOG4105CJ1 ABC, transporter BHV55_RS26895 ENOG41090WU lipolytic protein G-D-S-L family BHV55_RS26910 ENOG4105D6E homoserine dehydrogenase BHV55_RS26935 ENOG4108Y4K DNA-binding transcriptional activator BHV55_RS26945 ENOG4105WH1 Two component transcriptional regulator luxr family BHV55_RS26950 ENOG4105BZU Histidine kinase BHV55_RS26955 ENOG4105DWF phosphomethylpyrimidine kinase BHV55_RS26960 ENOG4105BZU Histidine kinase BHV55_RS26965 ENOG4105VCD cytoplasmic protein BHV55_RS26970 ENOG4105D22 carbon starvation protein BHV55_RS26975 ENOG4105DY9 regulatoR BHV55_RS26980 ENOG41079KZ Major Facilitator Superfamily BHV55_RS26990 ENOG4105CG5 Glycosyl transferase (Group 1 BHV55_RS27000 ENOG4105EN6 Membrane BHV55_RS27005 ENOG4106YBV Methyl-accepting chemotaxis BHV55_RS27015 ENOG4108S4H thioesterase Superfamily protein BHV55_RS27020 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BHV55_RS27035 ENOG4107VDP teichoic acid biosynthesis BHV55_RS27050 ENOG4105C5H ABC transporter BHV55_RS27055 ENOG41067SE Tetr family transcriptional regulator BHV55_RS27065 ENOG4105E0X reductase BHV55_RS27070 ENOG4106F5Q Membrane BHV55_RS27085 ENOG4108NEV two component transcriptional regulator, LytTR family BHV55_RS27090 ENOG4108HRK Histidine kinase BHV55_RS27095 ENOG4107RGD Major Facilitator superfamily BHV55_RS27110 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BHV55_RS27120 ENOG4105IW1 AmiS UreI transporter BHV55_RS27125 ENOG4105CMR udp-glucose 4-epimerase BHV55_RS27130 ENOG4108UT2 hemolysin iii BHV55_RS27140 ENOG4105C1J atp-dependent rna helicase BHV55_RS27150 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BHV55_RS27170 ENOG4105BZU Histidine kinase BHV55_RS27185 ENOG4105C0H protease BHV55_RS27190 ENOG4105Q2H domain protein BHV55_RS27205 ENOG4105BZU Histidine kinase BHV55_RS27210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHV55_RS27235 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BHV55_RS27240 ENOG4105CDU Replicative dna helicase BHV55_RS27250 ENOG4105BZR domain protein BHV55_RS27265 ENOG4108UUM single-stranded DNA-binding protein BHV55_RS27275 ENOG4105C3G gtp-binding protein BHV55_RS27280 ENOG4105VDK protein, conserved in bacteria BHV55_RS27285 ENOG4105D8X mechanosensitive ion channel BHV55_RS27290 ENOG4108ZDA Sporulation protein YyaC BHV55_RS27295 ENOG4105FA0 parb-like partition protein BHV55_RS27300 ENOG4107QJE Chromosome Partitioning Protein BHV55_RS27320 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BHV55_RS27330 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins