locus-tag	class	description
DI291_RS00010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DI291_RS00015	COG1263	PTS System
DI291_RS00015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS00020	COG0359	binds to the 23S rRNA
DI291_RS00025	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DI291_RS00030	COG4241	membrane
DI291_RS00040	COG5577	PFAM Coat F domain
DI291_RS00045	COG0589	response to stress
DI291_RS00050	COG0659	secondary active sulfate transmembrane transporter activity
DI291_RS00055	COG2271	Major facilitator Superfamily
DI291_RS00060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DI291_RS00065	COG0629	single-stranded DNA binding
DI291_RS00070	COG0360	Binds together with S18 to 16S ribosomal RNA
DI291_RS00075	COG0012	GTP binding
DI291_RS00080	COG4481	Protein conserved in bacteria
DI291_RS00085	COG3949	Membrane
DI291_RS00095	COG1475	DNA binding
DI291_RS00100	COG1192	Involved in chromosome partitioning
DI291_RS00105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DI291_RS00110	COG1595	DNA-templated transcription, initiation
DI291_RS00115	COG1475	DNA binding
DI291_RS00120	COG0357	Ribosomal RNA small subunit methyltransferase G
DI291_RS00125	COG0445	tRNA wobble uridine modification
DI291_RS00130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DI291_RS00135	COG1847	R3H domain protein
DI291_RS00140	COG0706	membrane insertase activity
DI291_RS00145	COG0594	ribonuclease P activity
DI291_RS00155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DI291_RS00160	COG0592	DNA-directed DNA polymerase activity
DI291_RS00165	COG2501	S4 domain
DI291_RS00170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DI291_RS00180	COG0187	DNA topoisomerase II activity
DI291_RS00185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DI291_RS00220	COG0517	IMP dehydrogenase activity
DI291_RS00220	COG0516	GMP reductase activity
DI291_RS00225	COG1686	Belongs to the peptidase S11 family
DI291_RS00230	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DI291_RS00235	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DI291_RS00240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DI291_RS00245	COG1929	Belongs to the glycerate kinase type-1 family
DI291_RS00250	COG2610	gluconate transmembrane transporter activity
DI291_RS00255	COG3835	regulator
DI291_RS00270	COG1428	Deoxynucleoside kinase
DI291_RS00275	COG1428	Deoxynucleoside kinase
DI291_RS00280	COG1388	LysM domain
DI291_RS00280	COG3858	chitin binding
DI291_RS00285	COG1335	isochorismatase
DI291_RS00290	COG0590	tRNA wobble adenosine to inosine editing
DI291_RS00300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DI291_RS00305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DI291_RS00310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DI291_RS00355	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DI291_RS00360	COG3853	Toxic anion resistance protein (TelA)
DI291_RS00365	COG1982	Orn Lys Arg decarboxylase major
DI291_RS00370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DI291_RS00375	COG3870	Protein conserved in bacteria
DI291_RS00380	COG1728	Protein conserved in bacteria
DI291_RS00385	COG0470	DNA polymerase III
DI291_RS00390	COG1774	PSP1 C-terminal conserved region
DI291_RS00395	COG4467	Involved in initiation control of chromosome replication
DI291_RS00400	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DI291_RS00405	COG2827	Endonuclease containing a URI domain
DI291_RS00410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DI291_RS00415	COG2002	toxin-antitoxin pair type II binding
DI291_RS00420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_RS00420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_RS00425	COG0084	hydrolase, TatD family'
DI291_RS00430	COG3583	domain protein
DI291_RS00430	COG3584	3D domain protein
DI291_RS00435	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DI291_RS00440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DI291_RS00450	COG4466	Protein conserved in bacteria
DI291_RS00460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DI291_RS00465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DI291_RS00470	COG0251	oxidation-reduction process
DI291_RS00475	COG2088	sporulation resulting in formation of a cellular spore
DI291_RS00480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DI291_RS00485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DI291_RS00490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DI291_RS00495	COG0193	aminoacyl-tRNA hydrolase activity
DI291_RS00505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DI291_RS00510	COG2002	toxin-antitoxin pair type II binding
DI291_RS00515	COG2244	polysaccharide biosynthetic process
DI291_RS00520	COG3956	TIGRFAM MazG family protein
DI291_RS00525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DI291_RS00540	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DI291_RS00545	COG1098	S1 RNA binding domain
DI291_RS00560	COG2208	phosphoserine phosphatase activity
DI291_RS00565	COG2304	oxidoreductase activity
DI291_RS00570	COG0515	serine threonine protein kinase
DI291_RS00575	COG0037	tRNA processing
DI291_RS00580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DI291_RS00585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DI291_RS00590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DI291_RS00595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DI291_RS00600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DI291_RS00605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DI291_RS00610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DI291_RS00615	COG0512	Glutamine amidotransferase of anthranilate synthase
DI291_RS00620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DI291_RS00625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DI291_RS00630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DI291_RS00635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DI291_RS00640	COG1396	sequence-specific DNA binding
DI291_RS00645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DI291_RS00650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DI291_RS00730	COG4463	regulation of RNA biosynthetic process
DI291_RS00735	COG3880	PFAM UvrB UvrC protein
DI291_RS00740	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DI291_RS00745	COG0542	response to heat
DI291_RS00750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DI291_RS00755	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DI291_RS00760	COG4956	integral membrane protein (PIN domain superfamily)
DI291_RS00765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DI291_RS00770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DI291_RS00775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DI291_RS00780	COG1045	serine acetyltransferase
DI291_RS00785	COG0215	cysteine-tRNA ligase activity
DI291_RS00790	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DI291_RS00795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DI291_RS00800	COG3688	RNA-binding protein containing a PIN domain
DI291_RS00820	COG0250	Participates in transcription elongation, termination and antitermination
DI291_RS00825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DI291_RS00830	COG0081	regulation of translation
DI291_RS00835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DI291_RS00840	COG0222	ribosome binding
DI291_RS00845	COG2813	Specifically methylates the guanine in position
DI291_RS00850	COG0085	RNA polymerase activity
DI291_RS00855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DI291_RS00860	COG1358	cellular component organization or biogenesis
DI291_RS00865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DI291_RS00870	COG0049	tRNA binding
DI291_RS00875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DI291_RS00880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DI291_RS00890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DI291_RS00895	COG0088	Forms part of the polypeptide exit tunnel
DI291_RS00900	COG0089	rRNA binding
DI291_RS00910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DI291_RS00915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DI291_RS00920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DI291_RS00925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DI291_RS00930	COG0255	Belongs to the universal ribosomal protein uL29 family
DI291_RS00935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DI291_RS00940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DI291_RS00945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DI291_RS00950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DI291_RS00955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DI291_RS00960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DI291_RS00965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DI291_RS00970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DI291_RS00975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DI291_RS00980	COG1841	ribosomal large subunit assembly
DI291_RS00985	COG0200	Binds to the 23S rRNA
DI291_RS00990	COG0201	protein transport
DI291_RS00995	COG0563	adenylate kinase activity
DI291_RS01000	COG0024	Methionine aminopeptidase
DI291_RS01005	COG2163	COG2163 Ribosomal protein L14E L6E L27E
DI291_RS01010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DI291_RS01015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DI291_RS01020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DI291_RS01025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DI291_RS01030	COG0202	RNA polymerase activity
DI291_RS01035	COG0203	ribosomal protein L17
DI291_RS01040	COG1122	ATPase activity
DI291_RS01045	COG1122	ATPase activity
DI291_RS01050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DI291_RS01055	COG0101	tRNA pseudouridine synthase activity
DI291_RS01060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DI291_RS01065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DI291_RS01070	COG2318	DinB family
DI291_RS01085	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_RS01090	COG0489	protein tyrosine kinase activity
DI291_RS01100	COG2194	sulfuric ester hydrolase activity
DI291_RS01105	COG0726	polysaccharide deacetylase
DI291_RS01135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI291_RS01145	COG0385	Bile acid
DI291_RS01160	COG3876	Protein conserved in bacteria
DI291_RS01165	COG1472	Belongs to the glycosyl hydrolase 3 family
DI291_RS01170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI291_RS01175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS01175	COG1263	PTS System
DI291_RS01180	COG1737	Transcriptional regulator
DI291_RS01185	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DI291_RS01190	COG1683	Conserved Protein
DI291_RS01225	COG1595	DNA-templated transcription, initiation
DI291_RS01230	COG5662	AntiSigma factor
DI291_RS01235	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DI291_RS01240	COG4856	YbbR-like protein
DI291_RS01245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DI291_RS01250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DI291_RS01270	COG1725	Transcriptional regulator
DI291_RS01280	COG0789	Transcriptional regulator
DI291_RS01290	COG0640	Transcriptional regulator
DI291_RS01295	COG2814	Major facilitator Superfamily
DI291_RS01335	COG1131	(ABC) transporter
DI291_RS01360	COG1132	(ABC) transporter
DI291_RS01365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DI291_RS01375	COG2312	Erythromycin esterase
DI291_RS01395	COG1011	Hydrolase
DI291_RS01400	COG1113	amino acid transport
DI291_RS01405	COG2851	Citrate transporter
DI291_RS01410	COG3181	Tripartite tricarboxylate transporter family receptor
DI291_RS01415	COG4565	transcriptional regulatory protein
DI291_RS01420	COG3290	protein histidine kinase activity
DI291_RS01435	COG2211	Major facilitator Superfamily
DI291_RS01455	COG1331	Highly conserved protein containing a thioredoxin domain
DI291_RS01460	COG1331	Highly conserved protein containing a thioredoxin domain
DI291_RS01470	COG1331	Highly conserved protein containing a thioredoxin domain
DI291_RS01480	COG2226	methyltransferase
DI291_RS01485	COG0076	glutamate decarboxylase activity
DI291_RS01490	COG0778	Nitroreductase
DI291_RS01495	COG1802	Transcriptional regulator
DI291_RS01500	COG0730	response to heat
DI291_RS01520	COG1283	sodium-dependent phosphate transmembrane transporter activity
DI291_RS01525	COG4682	membrane
DI291_RS01550	COG0697	spore germination
DI291_RS01555	COG1917	Cupin 2, conserved barrel domain protein
DI291_RS01555	COG2207	Transcriptional regulator
DI291_RS01565	COG2197	response regulator
DI291_RS01580	COG0371	Dehydrogenase
DI291_RS01595	COG4257	antibiotic catabolic process
DI291_RS01605	COG0833	amino acid
DI291_RS01610	COG2040	homocysteine
DI291_RS01620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS01620	COG1263	PTS System
DI291_RS01630	COG2323	membrane
DI291_RS01635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DI291_RS01635	COG4451	ribulose bisphosphate carboxylase, small
DI291_RS01650	COG2205	protein histidine kinase activity
DI291_RS01655	COG1115	amino acid carrier protein
DI291_RS01660	COG2066	Belongs to the glutaminase family
DI291_RS01665	COG4191	Histidine kinase
DI291_RS01670	COG0784	Response regulator, receiver
DI291_RS01695	COG3540	Alkaline phosphatase
DI291_RS01700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DI291_RS01705	COG0805	protein transport
DI291_RS01710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DI291_RS01715	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS01720	COG2271	Major facilitator Superfamily
DI291_RS01725	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_RS01730	COG2186	Transcriptional regulator
DI291_RS01735	COG2721	sulfolactate sulfo-lyase activity
DI291_RS01755	COG0745	RESPONSE REGULATOR receiver
DI291_RS01760	COG2205	protein histidine kinase activity
DI291_RS01765	COG1131	(ABC) transporter
DI291_RS01790	COG3173	Aminoglycoside phosphotransferase
DI291_RS01795	COG1846	Transcriptional regulator
DI291_RS01800	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_RS01820	COG0789	Transcriptional regulator
DI291_RS01845	COG0697	spore germination
DI291_RS01850	COG1714	RDD family
DI291_RS01855	COG3012	SEC-C Motif Domain Protein
DI291_RS01855	COG1405	negative regulation of cell septum assembly
DI291_RS01860	COG1131	(ABC) transporter
DI291_RS01885	COG0583	DNA-binding transcription factor activity
DI291_RS01890	COG1942	4-Oxalocrotonate Tautomerase
DI291_RS01895	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS01910	COG1288	antiporter activity
DI291_RS01920	COG0252	asparaginase activity
DI291_RS01925	COG0456	acetyltransferase
DI291_RS01935	COG1164	Oligoendopeptidase f
DI291_RS01940	COG2261	transglycosylase associated protein
DI291_RS01950	COG0247	lactate metabolic process
DI291_RS01955	COG0277	FAD linked oxidase domain protein
DI291_RS01960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_RS01965	COG1447	Phosphotransferase system cellobiose-specific component IIA
DI291_RS01970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_RS01975	COG1486	melibiose metabolic process
DI291_RS01980	COG2188	Transcriptional regulator
DI291_RS01985	COG3394	polysaccharide catabolic process
DI291_RS02000	COG3591	Belongs to the peptidase S1B family
DI291_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS02015	COG1595	DNA-templated transcription, initiation
DI291_RS02025	COG3773	Cell wall hydrolase
DI291_RS02030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DI291_RS02035	COG3883	PFAM NLP P60 protein
DI291_RS02035	COG0791	NLP P60 protein
DI291_RS02045	COG1131	(ABC) transporter
DI291_RS02050	COG1309	transcriptional regulator
DI291_RS02070	COG2310	stress, protein
DI291_RS02075	COG2310	stress, protein
DI291_RS02080	COG2310	stress, protein
DI291_RS02085	COG0861	Integral membrane protein TerC family
DI291_RS02105	COG3853	Toxic anion resistance protein (TelA)
DI291_RS02110	COG0785	Cytochrome C biogenesis protein
DI291_RS02120	COG2223	nitrite transmembrane transporter activity
DI291_RS02125	COG0039	L-malate dehydrogenase activity
DI291_RS02130	COG1620	l-lactate permease
DI291_RS02135	COG1280	lysine exporter protein (LysE YggA)
DI291_RS02140	COG1113	amino acid transport
DI291_RS02145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DI291_RS02150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DI291_RS02155	COG3541	Predicted nucleotidyltransferase
DI291_RS02160	COG0506	proline dehydrogenase activity
DI291_RS02165	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS02170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_RS02175	COG2508	Transcriptional regulator
DI291_RS02180	COG3689	TIGRFAM TIGR03943 family protein
DI291_RS02185	COG0701	Predicted permease
DI291_RS02190	COG3458	cephalosporin-C deacetylase activity
DI291_RS02210	COG0765	amino acid transport
DI291_RS02215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DI291_RS02220	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_RS02225	COG1116	anion transmembrane transporter activity
DI291_RS02230	COG2723	6-phospho-beta-galactosidase activity
DI291_RS02240	COG3209	COG3209 Rhs family protein
DI291_RS02255	COG5444	nuclease activity
DI291_RS02285	COG1177	transmembrane transport
DI291_RS02290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS02295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS02300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS02305	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DI291_RS02310	COG0697	spore germination
DI291_RS02315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_RS02325	COG2819	hydrolase of the alpha beta superfamily
DI291_RS02330	COG3708	Transcriptional regulator
DI291_RS02330	COG2207	Transcriptional regulator
DI291_RS02335	COG2364	Membrane
DI291_RS02360	COG1126	abc transporter atp-binding protein
DI291_RS02365	COG0765	amino acid transport
DI291_RS02370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DI291_RS02375	COG3829	transcription factor binding
DI291_RS02380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DI291_RS02385	COG0833	amino acid
DI291_RS02390	COG0010	Belongs to the arginase family
DI291_RS02395	COG0583	DNA-binding transcription factor activity
DI291_RS02400	COG0163	prenyltransferase activity
DI291_RS02405	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DI291_RS02475	COG2972	Histidine kinase
DI291_RS02480	COG2207	Transcriptional regulator
DI291_RS02480	COG4753	response regulator
DI291_RS02485	COG4213	ABC transporter substrate-binding protein
DI291_RS02495	COG4214	carbohydrate transport
DI291_RS02500	COG2271	Major facilitator Superfamily
DI291_RS02505	COG1846	Transcriptional regulator
DI291_RS02505	COG0456	acetyltransferase
DI291_RS02510	COG1874	Beta-galactosidase
DI291_RS02520	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
DI291_RS02530	COG3104	oligopeptide transport
DI291_RS02535	COG5434	Belongs to the glycosyl hydrolase 28 family
DI291_RS02545	COG0697	spore germination
DI291_RS02555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DI291_RS02560	COG0789	Transcriptional regulator
DI291_RS02565	COG1136	(ABC) transporter
DI291_RS02570	COG0577	efflux transmembrane transporter activity
DI291_RS02575	COG0745	RESPONSE REGULATOR receiver
DI291_RS02580	COG3850	Histidine kinase
DI291_RS02580	COG5002	protein histidine kinase activity
DI291_RS02585	COG0840	transmembrane signaling receptor activity
DI291_RS02590	COG0527	aspartate kinase activity
DI291_RS02595	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS02600	COG4605	iron ion homeostasis
DI291_RS02605	COG4604	ABC transporter, ATP-binding protein
DI291_RS02610	COG4607	ABC-type enterochelin transport system periplasmic component
DI291_RS02615	COG2814	Major facilitator Superfamily
DI291_RS02620	COG1309	transcriptional regulator
DI291_RS02630	COG0778	Nitroreductase
DI291_RS02635	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DI291_RS02640	COG0640	Transcriptional regulator
DI291_RS02645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_RS02650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DI291_RS02655	COG0531	amino acid
DI291_RS02660	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS02665	COG0697	spore germination
DI291_RS02675	COG4549	nuclear export factor GLE1
DI291_RS02680	COG2372	response to copper ion
DI291_RS02680	COG1276	copper resistance
DI291_RS02685	COG1349	DNA-binding transcription factor activity
DI291_RS02690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DI291_RS02695	COG0243	molybdopterin cofactor binding
DI291_RS02700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DI291_RS02705	COG2146	nitrite reductase [NAD(P)H] activity
DI291_RS02710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DI291_RS02710	COG1587	Uroporphyrinogen-III synthase
DI291_RS02715	COG1802	Transcriptional regulator
DI291_RS02720	COG0471	metal ion transport
DI291_RS02725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DI291_RS02735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS02750	COG3959	Transketolase, thiamine diphosphate binding domain
DI291_RS02755	COG3958	Transketolase
DI291_RS02760	COG0561	phosphatase activity
DI291_RS02765	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DI291_RS02770	COG1914	H( )-stimulated, divalent metal cation uptake system
DI291_RS02775	COG4336	lyase activity
DI291_RS02780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DI291_RS02785	COG1984	allophanate hydrolase subunit 2
DI291_RS02790	COG1414	Transcriptional regulator
DI291_RS02795	COG2755	lipolytic protein G-D-S-L family
DI291_RS02800	COG2213	PTS system mannitol-specific
DI291_RS02805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS02810	COG0246	Mannitol dehydrogenase
DI291_RS02815	COG3711	transcriptional antiterminator
DI291_RS02820	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS02825	COG1917	Cupin 2, conserved barrel domain protein
DI291_RS02835	COG3871	stress protein (general stress protein 26)
DI291_RS02850	COG2814	Major facilitator Superfamily
DI291_RS02860	COG1522	sequence-specific DNA binding
DI291_RS02865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DI291_RS02865	COG0551	DNA topoisomerase type I activity
DI291_RS02870	COG0287	Prephenate dehydrogenase
DI291_RS02875	COG0512	Glutamine amidotransferase of anthranilate synthase
DI291_RS02875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DI291_RS02880	COG1605	Chorismate mutase
DI291_RS02885	COG0028	Belongs to the TPP enzyme family
DI291_RS02890	COG3397	chitin binding
DI291_RS02900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_RS02905	COG1914	H( )-stimulated, divalent metal cation uptake system
DI291_RS02910	COG2261	transglycosylase associated protein
DI291_RS02915	COG1027	Aspartate ammonia-lyase
DI291_RS02920	COG1819	glycosyl
DI291_RS02925	COG4876	unkown
DI291_RS02930	COG2217	Heavy metal translocating P-type atpase
DI291_RS02940	COG0662	Cupin 2, conserved barrel domain protein
DI291_RS02950	COG0628	permease
DI291_RS02955	COG1301	dicarboxylic acid transport
DI291_RS02960	COG1131	(ABC) transporter
DI291_RS02965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DI291_RS02975	COG1960	acyl-CoA dehydrogenase activity
DI291_RS02990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS02995	COG1181	Belongs to the D-alanine--D-alanine ligase family
DI291_RS03000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DI291_RS03010	COG0513	Belongs to the DEAD box helicase family
DI291_RS03015	COG3402	PFAM membrane-flanked domain
DI291_RS03020	COG3428	Bacterial PH domain
DI291_RS03025	COG0705	Rhomboid family
DI291_RS03030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DI291_RS03035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DI291_RS03040	COG0864	Transcriptional regulator
DI291_RS03045	COG2337	Toxic component of a toxin-antitoxin (TA) module
DI291_RS03050	COG1366	Belongs to the anti-sigma-factor antagonist family
DI291_RS03055	COG1366	Belongs to the anti-sigma-factor antagonist family
DI291_RS03060	COG2172	sigma factor antagonist activity
DI291_RS03065	COG2208	phosphoserine phosphatase activity
DI291_RS03080	COG1191	sigma factor activity
DI291_RS03085	COG2208	phosphoserine phosphatase activity
DI291_RS03090	COG2183	response to ionizing radiation
DI291_RS03095	COG1309	transcriptional regulator
DI291_RS03105	COG2409	Drug exporters of the RND superfamily
DI291_RS03105	COG1033	growth of symbiont in host cell
DI291_RS03115	COG3091	SprT-like family
DI291_RS03155	COG0697	spore germination
DI291_RS03160	COG0582	viral genome integration into host DNA
DI291_RS03190	COG0726	polysaccharide deacetylase
DI291_RS03195	COG3239	Fatty acid desaturase
DI291_RS03200	COG1278	Cold shock
DI291_RS03225	COG2364	Membrane
DI291_RS03230	COG1846	Transcriptional regulator
DI291_RS03235	COG0456	acetyltransferase
DI291_RS03240	COG2808	Putative FMN-binding domain
DI291_RS03250	COG1733	regulation of RNA biosynthetic process
DI291_RS03255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_RS03270	COG3545	Serine hydrolase
DI291_RS03275	COG1733	regulation of RNA biosynthetic process
DI291_RS03280	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DI291_RS03285	COG1113	amino acid transport
DI291_RS03300	COG0596	Alpha beta hydrolase
DI291_RS03305	COG5566	PFAM Mor transcription activator
DI291_RS03310	COG1595	DNA-templated transcription, initiation
DI291_RS03320	COG2755	lipolytic protein G-D-S-L family
DI291_RS03320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DI291_RS03325	COG0494	nUDIX hydrolase
DI291_RS03330	COG2814	Major facilitator Superfamily
DI291_RS03335	COG1979	alcohol dehydrogenase
DI291_RS03340	COG2972	Histidine kinase
DI291_RS03340	COG0745	RESPONSE REGULATOR receiver
DI291_RS03345	COG3279	Response regulator of the LytR AlgR family
DI291_RS03355	COG3764	Sortase (surface protein transpeptidase)
DI291_RS03360	COG2814	Major facilitator Superfamily
DI291_RS03400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DI291_RS03405	COG0802	atpase or kinase
DI291_RS03410	COG1214	PFAM Peptidase M22, glycoprotease
DI291_RS03415	COG0456	acetyltransferase
DI291_RS03420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DI291_RS03425	COG0488	(ABC) transporter
DI291_RS03430	COG0315	cyclic pyranopterin monophosphate synthase activity
DI291_RS03435	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DI291_RS03440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DI291_RS03445	COG0805	protein transport
DI291_RS03455	COG1266	CAAX protease self-immunity
DI291_RS03460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DI291_RS03465	COG0459	protein refolding
DI291_RS03470	COG2720	vancomycin resistance protein
DI291_RS03490	COG2135	peptidase activity
DI291_RS03500	COG1309	transcriptional regulator
DI291_RS03505	COG3848	Pyruvate phosphate dikinase
DI291_RS03505	COG0574	Belongs to the PEP-utilizing enzyme family
DI291_RS03515	COG3189	MarR family transcriptional regulator
DI291_RS03520	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DI291_RS03525	COG2272	Belongs to the type-B carboxylesterase lipase family
DI291_RS03530	COG2814	Major facilitator Superfamily
DI291_RS03535	COG1842	Phage shock protein A
DI291_RS03540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DI291_RS03545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DI291_RS03550	COG4260	virion core protein, lumpy skin disease virus
DI291_RS03560	COG1378	Sugar-specific transcriptional regulator TrmB
DI291_RS03565	COG1280	lysine exporter protein (LysE YggA)
DI291_RS03570	COG3339	Conserved Protein
DI291_RS03575	COG0772	Belongs to the SEDS family
DI291_RS03580	COG0772	Belongs to the SEDS family
DI291_RS03600	COG0726	polysaccharide deacetylase
DI291_RS03610	COG1609	Transcriptional regulator
DI291_RS03615	COG0366	Alpha amylase catalytic
DI291_RS03620	COG2182	Extracellular solute-binding protein
DI291_RS03625	COG1175	transmembrane transport
DI291_RS03630	COG3833	ABC-type maltose transport systems, permease component
DI291_RS03635	COG5521	maltodextrose utilization protein MalA
DI291_RS03640	COG1554	hydrolase, family 65, central catalytic
DI291_RS03645	COG0366	Alpha amylase catalytic
DI291_RS03650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DI291_RS03655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DI291_RS03660	COG1846	Transcriptional regulator
DI291_RS03675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DI291_RS03680	COG0823	Involved in the tonB-independent uptake of proteins
DI291_RS03710	COG0702	epimerase
DI291_RS03720	COG2132	Multicopper oxidase
DI291_RS03740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DI291_RS03745	COG0714	Associated with various cellular activities
DI291_RS03750	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DI291_RS03755	COG1305	Transglutaminase-like
DI291_RS03760	COG0519	Catalyzes the synthesis of GMP from XMP
DI291_RS03760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DI291_RS03770	COG2252	PERMEase
DI291_RS03785	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DI291_RS03795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DI291_RS03800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DI291_RS03805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DI291_RS03810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DI291_RS03815	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DI291_RS03820	COG0047	phosphoribosylformylglycinamidine synthase activity
DI291_RS03825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DI291_RS03830	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DI291_RS03835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DI291_RS03840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DI291_RS03845	COG0138	bifunctional purine biosynthesis protein purh
DI291_RS03850	COG0151	Belongs to the GarS family
DI291_RS03860	COG2124	cytochrome p450
DI291_RS03880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DI291_RS03885	COG1470	cell adhesion involved in biofilm formation
DI291_RS03890	COG4496	protein, YerC YecD
DI291_RS03895	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DI291_RS03900	COG0210	DNA helicase
DI291_RS03905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DI291_RS03910	COG4851	CamS sex pheromone cAM373 precursor
DI291_RS03915	COG1285	pathogenesis
DI291_RS03920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_RS03925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DI291_RS03930	COG0154	amidase activity
DI291_RS03935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DI291_RS03950	COG4124	Belongs to the glycosyl hydrolase 26 family
DI291_RS03955	COG1309	transcriptional regulator
DI291_RS03960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DI291_RS03970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_RS03975	COG1957	nucleoside hydrolase
DI291_RS03980	COG1597	lipid kinase activity
DI291_RS03985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DI291_RS04005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DI291_RS04015	COG1263	PTS System
DI291_RS04015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS04015	COG2190	(PTS) system
DI291_RS04020	COG2723	6-phospho-beta-galactosidase activity
DI291_RS04025	COG3711	transcriptional antiterminator
DI291_RS04030	COG0457	Tetratricopeptide repeat
DI291_RS04045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DI291_RS04045	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DI291_RS04050	COG3586	endonuclease activity
DI291_RS04055	COG0697	spore germination
DI291_RS04060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_RS04065	COG0697	spore germination
DI291_RS04070	COG0217	transcriptional regulatory protein
DI291_RS04085	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS04090	COG0840	transmembrane signaling receptor activity
DI291_RS04095	COG0109	protoheme IX farnesyltransferase activity
DI291_RS04100	COG1309	transcriptional regulator
DI291_RS04105	COG0471	metal ion transport
DI291_RS04110	COG0488	(ABC) transporter
DI291_RS04120	COG1469	GTP cyclohydrolase I activity
DI291_RS04135	COG0523	cobalamin synthesis protein
DI291_RS04140	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
DI291_RS04145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DI291_RS04150	COG0156	8-amino-7-oxononanoate synthase activity
DI291_RS04155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DI291_RS04160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DI291_RS04165	COG2124	cytochrome p450
DI291_RS04175	COG0789	Transcriptional regulator
DI291_RS04180	COG2814	Major facilitator Superfamily
DI291_RS04185	COG0488	(ABC) transporter
DI291_RS04190	COG0513	Belongs to the DEAD box helicase family
DI291_RS04195	COG2130	NADP-dependent
DI291_RS04210	COG0471	metal ion transport
DI291_RS04220	COG1136	(ABC) transporter
DI291_RS04240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_RS04250	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DI291_RS04255	COG3858	chitin binding
DI291_RS04260	COG5658	integral membrane protein
DI291_RS04265	COG0640	Transcriptional regulator
DI291_RS04270	COG1254	Belongs to the acylphosphatase family
DI291_RS04275	COG2258	MOSC domain
DI291_RS04290	COG0024	Methionine aminopeptidase
DI291_RS04295	COG1368	sulfuric ester hydrolase activity
DI291_RS04305	COG1115	amino acid carrier protein
DI291_RS04310	COG1263	PTS System
DI291_RS04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS04315	COG0366	Alpha amylase catalytic
DI291_RS04320	COG2188	Transcriptional regulator
DI291_RS04355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DI291_RS04360	COG1045	serine acetyltransferase
DI291_RS04365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI291_RS04375	COG1215	transferase activity, transferring glycosyl groups
DI291_RS04380	COG0457	Tetratricopeptide repeat
DI291_RS04380	COG0463	Glycosyl transferase, family 2
DI291_RS04390	COG0673	inositol 2-dehydrogenase activity
DI291_RS04405	COG1733	regulation of RNA biosynthetic process
DI291_RS04410	COG0778	Nitroreductase
DI291_RS04415	COG0737	Belongs to the 5'-nucleotidase family
DI291_RS04420	COG0693	protein deglycase activity
DI291_RS04425	COG4840	Belongs to the UPF0435 family
DI291_RS04430	COG1115	amino acid carrier protein
DI291_RS04435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DI291_RS04440	COG4980	gas vesicle protein
DI291_RS04445	COG1295	ribonuclease BN
DI291_RS04450	COG0477	Major facilitator Superfamily
DI291_RS04460	COG0387	Pfam Sodium calcium exchanger
DI291_RS04470	COG0535	radical SAM domain protein
DI291_RS04480	COG0726	polysaccharide deacetylase
DI291_RS04485	COG0371	Dehydrogenase
DI291_RS04495	COG0598	Magnesium transport protein CorA
DI291_RS04500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DI291_RS04505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DI291_RS04510	COG4637	Psort location Cytoplasmic, score
DI291_RS04535	COG1819	glycosyl
DI291_RS04545	COG0477	Major facilitator Superfamily
DI291_RS04555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS04555	COG1263	PTS System
DI291_RS04560	COG3711	transcriptional antiterminator
DI291_RS04565	COG0288	reversible hydration of carbon dioxide
DI291_RS04570	COG3002	Belongs to the UPF0753 family
DI291_RS04575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DI291_RS04580	COG5609	conserved protein (DUF2294)
DI291_RS04590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DI291_RS04595	COG0022	dehydrogenase e1 component
DI291_RS04600	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI291_RS04605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DI291_RS04610	COG3284	Transcriptional regulator
DI291_RS04615	COG1742	UPF0060 membrane protein
DI291_RS04620	COG1486	melibiose metabolic process
DI291_RS04625	COG1737	Transcriptional regulator
DI291_RS04630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS04630	COG1263	PTS System
DI291_RS04645	COG1733	regulation of RNA biosynthetic process
DI291_RS04650	COG2259	Doxx family
DI291_RS04655	COG2514	catechol 2,3-dioxygenase activity
DI291_RS04665	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_RS04675	COG1653	transport
DI291_RS04680	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_RS04685	COG1051	belongs to the nudix hydrolase family
DI291_RS04695	COG0392	lysyltransferase activity
DI291_RS04695	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DI291_RS04700	COG0384	phenazine biosynthesis protein PhzF
DI291_RS04705	COG0778	Nitroreductase
DI291_RS04725	COG1090	epimerase
DI291_RS04730	COG2137	regulation of response to DNA damage stimulus
DI291_RS04755	COG0463	Glycosyl transferase, family 2
DI291_RS04765	COG4485	Bacterial membrane protein, YfhO
DI291_RS04770	COG1988	membrane-bound metal-dependent
DI291_RS04775	COG1194	a g-specific adenine glycosylase
DI291_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS04800	COG3557	Belongs to the UPF0374 family
DI291_RS04805	COG1132	(ABC) transporter
DI291_RS04810	COG0444	Belongs to the ABC transporter superfamily
DI291_RS04815	COG4608	Belongs to the ABC transporter superfamily
DI291_RS04820	COG0747	negative chemotaxis
DI291_RS04825	COG0601	transmembrane transport
DI291_RS04830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_RS04835	COG4129	membrane
DI291_RS04840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DI291_RS04845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DI291_RS04850	COG0735	belongs to the Fur family
DI291_RS04975	COG0582	viral genome integration into host DNA
DI291_RS05025	COG0457	Tetratricopeptide repeat
DI291_RS05030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DI291_RS05050	COG0710	3-dehydroquinate dehydratase activity
DI291_RS05055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DI291_RS05060	COG1116	anion transmembrane transporter activity
DI291_RS05065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DI291_RS05070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DI291_RS05075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DI291_RS05085	COG1476	TRANSCRIPTIONal
DI291_RS05095	COG1131	(ABC) transporter
DI291_RS05115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DI291_RS05125	COG3382	B3 4 domain protein
DI291_RS05130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DI291_RS05140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DI291_RS05145	COG0789	Transcriptional regulator
DI291_RS05150	COG1664	Polymer-forming cytoskeletal
DI291_RS05155	COG1664	Polymer-forming cytoskeletal
DI291_RS05165	COG2766	serine protein kinase
DI291_RS05170	COG2718	Belongs to the UPF0229 family
DI291_RS05175	COG1566	PFAM secretion protein HlyD family protein
DI291_RS05180	COG2814	Major facilitator Superfamily
DI291_RS05185	COG0655	NAD(P)H dehydrogenase (quinone) activity
DI291_RS05200	COG1725	Transcriptional regulator
DI291_RS05205	COG1131	(ABC) transporter
DI291_RS05210	COG1131	(ABC) transporter
DI291_RS05215	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DI291_RS05220	COG1278	Cold shock
DI291_RS05225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DI291_RS05230	COG2011	ABC-type metal ion transport system permease component
DI291_RS05235	COG1464	Belongs to the NlpA lipoprotein family
DI291_RS05240	COG1823	symporter activity
DI291_RS05265	COG5577	PFAM Coat F domain
DI291_RS05270	COG5002	protein histidine kinase activity
DI291_RS05275	COG0737	Belongs to the 5'-nucleotidase family
DI291_RS05275	COG1525	nuclease
DI291_RS05275	COG4085	toxin activity
DI291_RS05280	COG3764	Sortase (surface protein transpeptidase)
DI291_RS05285	COG0564	pseudouridine synthase activity
DI291_RS05295	COG0517	IMP dehydrogenase activity
DI291_RS05300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DI291_RS05305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DI291_RS05305	COG3153	acetyltransferase
DI291_RS05310	COG0488	(ABC) transporter
DI291_RS05315	COG2116	formate transmembrane transporter activity
DI291_RS05330	COG0604	alcohol dehydrogenase
DI291_RS05335	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DI291_RS05340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DI291_RS05345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DI291_RS05350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DI291_RS05355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DI291_RS05370	COG4585	Histidine kinase
DI291_RS05370	COG2203	Gaf domain
DI291_RS05375	COG2197	response regulator
DI291_RS05380	COG0431	NADPH-dependent FMN reductase
DI291_RS05395	COG1959	2 iron, 2 sulfur cluster binding
DI291_RS05400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DI291_RS05400	COG1017	nitric oxide dioxygenase activity
DI291_RS05405	COG2719	SpoVR family
DI291_RS05410	COG0791	NLP P60 protein
DI291_RS05410	COG1388	LysM domain
DI291_RS05415	COG0583	DNA-binding transcription factor activity
DI291_RS05420	COG0372	Belongs to the citrate synthase family
DI291_RS05425	COG2133	pyrroloquinoline quinone binding
DI291_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS05435	COG0733	neurotransmitter:sodium symporter activity
DI291_RS05445	COG2207	Transcriptional regulator
DI291_RS05445	COG3708	Transcriptional regulator
DI291_RS05450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_RS05470	COG1595	DNA-templated transcription, initiation
DI291_RS05475	COG0662	Cupin 2, conserved barrel domain protein
DI291_RS05480	COG0667	Aldo Keto reductase
DI291_RS05485	COG0204	Acyl-transferase
DI291_RS05490	COG3152	Membrane
DI291_RS05505	COG1253	flavin adenine dinucleotide binding
DI291_RS05510	COG0789	Transcriptional regulator
DI291_RS05515	COG1253	flavin adenine dinucleotide binding
DI291_RS05535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DI291_RS05540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DI291_RS05545	COG0584	glycerophosphoryl diester phosphodiesterase
DI291_RS05555	COG0668	transmembrane transport
DI291_RS05560	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DI291_RS05570	COG0726	polysaccharide deacetylase
DI291_RS05580	COG1757	Na H antiporter
DI291_RS05585	COG2017	converts alpha-aldose to the beta-anomer
DI291_RS05610	COG0589	response to stress
DI291_RS05615	COG1132	(ABC) transporter
DI291_RS05620	COG1132	(ABC) transporter
DI291_RS05625	COG0702	epimerase
DI291_RS05645	COG3842	ATPase activity
DI291_RS05650	COG2508	Transcriptional regulator
DI291_RS05660	COG0189	ligase activity
DI291_RS05665	COG0189	ligase activity
DI291_RS05670	COG4399	Belongs to the UPF0754 family
DI291_RS05675	COG3679	Belongs to the UPF0342 family
DI291_RS05680	COG0561	phosphatase activity
DI291_RS05685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DI291_RS05690	COG1024	Enoyl-CoA hydratase
DI291_RS05695	COG0457	Tetratricopeptide repeat
DI291_RS05715	COG4152	abc transporter atp-binding protein
DI291_RS05720	COG1668	transmembrane transport
DI291_RS05725	COG0420	3'-5' exonuclease activity
DI291_RS05730	COG4717	serine-type aminopeptidase activity
DI291_RS05735	COG3481	metal-dependent phosphohydrolase, HD sub domain
DI291_RS05745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DI291_RS05775	COG1846	Transcriptional regulator
DI291_RS05780	COG4980	gas vesicle protein
DI291_RS05795	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DI291_RS05800	COG0537	adenosine 5'-monophosphoramidase activity
DI291_RS05805	COG1131	(ABC) transporter
DI291_RS05810	COG4473	ABC transporter
DI291_RS05820	COG1473	amidohydrolase
DI291_RS05825	COG3069	C4-dicarboxylate transmembrane transporter activity
DI291_RS05830	COG2329	Antibiotic biosynthesis monooxygenase
DI291_RS05835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DI291_RS05840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DI291_RS05845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DI291_RS05850	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DI291_RS05855	COG1309	transcriptional regulator
DI291_RS05860	COG1511	domain protein
DI291_RS05865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI291_RS05870	COG1363	Peptidase, m42
DI291_RS05880	COG1301	dicarboxylic acid transport
DI291_RS05890	COG1234	tRNA 3'-trailer cleavage
DI291_RS05895	COG0095	Lipoate-protein ligase
DI291_RS05900	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_RS05910	COG1396	sequence-specific DNA binding
DI291_RS05925	COG0501	Belongs to the peptidase M48B family
DI291_RS05935	COG0697	spore germination
DI291_RS05940	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DI291_RS05945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS05950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS05955	COG0406	alpha-ribazole phosphatase activity
DI291_RS05960	COG0840	transmembrane signaling receptor activity
DI291_RS05965	COG0723	plastoquinol--plastocyanin reductase activity
DI291_RS05965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DI291_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS05980	COG4903	ComK protein
DI291_RS05990	COG0398	Pfam SNARE associated Golgi protein
DI291_RS05995	COG0681	Belongs to the peptidase S26 family
DI291_RS06000	COG1404	Belongs to the peptidase S8 family
DI291_RS06010	COG2508	Transcriptional regulator
DI291_RS06015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DI291_RS06020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DI291_RS06025	COG3257	ureidoglycine aminohydrolase activity
DI291_RS06030	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DI291_RS06035	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DI291_RS06040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DI291_RS06045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DI291_RS06055	COG0549	Belongs to the carbamate kinase family
DI291_RS06060	COG2814	Major facilitator Superfamily
DI291_RS06070	COG0457	Tetratricopeptide repeat
DI291_RS06085	COG1609	Transcriptional regulator
DI291_RS06090	COG1653	transport
DI291_RS06095	COG1175	transmembrane transport
DI291_RS06100	COG0395	ABC-type sugar transport system, permease component
DI291_RS06105	COG1486	melibiose metabolic process
DI291_RS06110	COG3180	Ammonia monooxygenase
DI291_RS06125	COG3546	catalase activity
DI291_RS06130	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_RS06135	COG2814	Major facilitator Superfamily
DI291_RS06135	COG0477	Major facilitator Superfamily
DI291_RS06140	COG4533	DNA binding
DI291_RS06150	COG5002	protein histidine kinase activity
DI291_RS06155	COG0745	RESPONSE REGULATOR receiver
DI291_RS06160	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DI291_RS06165	COG0725	ABC transporter, periplasmic molybdate-binding protein
DI291_RS06170	COG4149	molybdate abc transporter
DI291_RS06175	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DI291_RS06180	COG1074	ATP-dependent DNA helicase activity
DI291_RS06185	COG0420	3'-5' exonuclease activity
DI291_RS06190	COG0419	ATPase involved in DNA repair
DI291_RS06235	COG5337	Spore coat protein CotH
DI291_RS06245	COG0179	Fumarylacetoacetate (FAA) hydrolase
DI291_RS06270	COG0367	asparagine synthase
DI291_RS06275	COG0004	ammonium transporteR
DI291_RS06280	COG0347	Belongs to the P(II) protein family
DI291_RS06285	COG0534	Mate efflux family protein
DI291_RS06290	COG2207	Transcriptional regulator
DI291_RS06290	COG1917	Cupin 2, conserved barrel domain protein
DI291_RS06300	COG1609	Transcriptional regulator
DI291_RS06305	COG0673	inositol 2-dehydrogenase activity
DI291_RS06320	COG0697	spore germination
DI291_RS06325	COG1279	arginine transmembrane transporter activity
DI291_RS06330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_RS06340	COG0076	glutamate decarboxylase activity
DI291_RS06365	COG2153	protein acetylation
DI291_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS06375	COG2378	regulation of single-species biofilm formation
DI291_RS06380	COG1410	methionine synthase
DI291_RS06380	COG0646	methionine synthase
DI291_RS06385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DI291_RS06385	COG0646	methionine synthase
DI291_RS06390	COG1666	GTP binding
DI291_RS06395	COG2996	Protein conserved in bacteria
DI291_RS06410	COG1307	EDD domain protein, DegV family
DI291_RS06415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_RS06425	COG0516	GMP reductase activity
DI291_RS06440	COG0561	phosphatase activity
DI291_RS06445	COG1073	alpha beta
DI291_RS06450	COG2151	metal-sulfur cluster biosynthetic enzyme
DI291_RS06455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DI291_RS06460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DI291_RS06465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DI291_RS06470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DI291_RS06475	COG0505	Belongs to the CarA family
DI291_RS06480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DI291_RS06485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DI291_RS06490	COG1968	undecaprenyl-diphosphatase activity
DI291_RS06505	COG2267	carboxylic ester hydrolase activity
DI291_RS06515	COG1744	ABC transporter substrate-binding protein PnrA-like
DI291_RS06530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI291_RS06535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DI291_RS06540	COG5504	Zn-dependent protease
DI291_RS06545	COG0444	Belongs to the ABC transporter superfamily
DI291_RS06550	COG4608	Belongs to the ABC transporter superfamily
DI291_RS06560	COG0601	transmembrane transport
DI291_RS06565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_RS06595	COG4166	transmembrane transport
DI291_RS06600	COG0601	transmembrane transport
DI291_RS06605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_RS06610	COG0444	Belongs to the ABC transporter superfamily
DI291_RS06615	COG4608	Belongs to the ABC transporter superfamily
DI291_RS06620	COG0456	acetyltransferase
DI291_RS06625	COG1393	Belongs to the ArsC family
DI291_RS06630	COG0861	Integral membrane protein TerC family
DI291_RS06640	COG4862	establishment of competence for transformation
DI291_RS06665	COG4565	transcriptional regulatory protein
DI291_RS06670	COG3290	protein histidine kinase activity
DI291_RS06675	COG4469	Competence protein
DI291_RS06680	COG1164	Oligoendopeptidase f
DI291_RS06685	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DI291_RS06690	COG2346	COG2346, Truncated hemoglobins
DI291_RS06695	COG0741	lytic transglycosylase activity
DI291_RS06700	COG4116	CYTH
DI291_RS06710	COG2357	RelA SpoT domain protein
DI291_RS06715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DI291_RS06720	COG0564	pseudouridine synthase activity
DI291_RS06725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DI291_RS06730	COG0569	domain protein
DI291_RS06730	COG0475	glutathione-regulated potassium exporter activity
DI291_RS06735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DI291_RS06740	COG0352	thiamine-phosphate diphosphorylase activity
DI291_RS06750	COG2104	thiamine diphosphate biosynthetic process
DI291_RS06755	COG2022	thiamine diphosphate biosynthetic process
DI291_RS06760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DI291_RS06765	COG0351	phosphomethylpyrimidine kinase
DI291_RS06770	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DI291_RS06825	COG0210	DNA helicase
DI291_RS06835	COG0586	Pfam SNARE associated Golgi protein
DI291_RS06840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DI291_RS06845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DI291_RS06850	COG2246	polysaccharide biosynthetic process
DI291_RS06855	COG2153	protein acetylation
DI291_RS06860	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DI291_RS06865	COG2382	esterase
DI291_RS06885	COG0626	cystathionine gamma-synthase activity
DI291_RS06890	COG0626	cystathionine gamma-synthase activity
DI291_RS06895	COG5505	Protein of unknown function (DUF819)
DI291_RS06910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI291_RS06920	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_RS06950	COG0110	maltose O-acetyltransferase activity
DI291_RS06960	COG0583	DNA-binding transcription factor activity
DI291_RS06965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DI291_RS06970	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DI291_RS06975	COG0583	DNA-binding transcription factor activity
DI291_RS06980	COG0697	spore germination
DI291_RS06985	COG0346	lactoylglutathione lyase activity
DI291_RS06995	COG3584	3D domain protein
DI291_RS06995	COG1388	LysM domain
DI291_RS07000	COG2814	Major facilitator Superfamily
DI291_RS07005	COG1309	transcriptional regulator
DI291_RS07020	COG4195	phage-related replication protein
DI291_RS07025	COG2856	Zn peptidase
DI291_RS07030	COG1396	sequence-specific DNA binding
DI291_RS07045	COG1522	sequence-specific DNA binding
DI291_RS07050	COG1484	DNA-dependent DNA replication
DI291_RS07070	COG1595	DNA-templated transcription, initiation
DI291_RS07075	COG5484	DNA packaging
DI291_RS07075	COG3728	DNA packaging
DI291_RS07080	COG1783	phage Terminase large subunit
DI291_RS07085	COG5518	Phage portal protein
DI291_RS07090	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DI291_RS07095	COG4653	Phage capsid family
DI291_RS07150	COG1652	LysM domain
DI291_RS07155	COG4193	domain, Protein
DI291_RS07165	COG3628	GPW Gp25 family protein
DI291_RS07170	COG3299	homolog of phage Mu protein gp47
DI291_RS07175	COG3778	Protein conserved in bacteria
DI291_RS07205	COG1802	Transcriptional regulator
DI291_RS07210	COG1063	alcohol dehydrogenase
DI291_RS07215	COG1312	Catalyzes the dehydration of D-mannonate
DI291_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS07225	COG1063	alcohol dehydrogenase
DI291_RS07230	COG2271	Major facilitator Superfamily
DI291_RS07245	COG0306	phosphate transporter
DI291_RS07250	COG1392	Phosphate transport regulator
DI291_RS07255	COG0405	Gamma-glutamyltransferase
DI291_RS07260	COG5578	integral membrane protein
DI291_RS07265	COG2972	Histidine kinase
DI291_RS07270	COG4753	response regulator
DI291_RS07270	COG2207	Transcriptional regulator
DI291_RS07275	COG1653	transport
DI291_RS07280	COG1175	transmembrane transport
DI291_RS07285	COG0395	ABC-type sugar transport system, permease component
DI291_RS07290	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DI291_RS07295	COG2207	Transcriptional regulator
DI291_RS07300	COG2755	lipolytic protein G-D-S-L family
DI291_RS07310	COG5578	integral membrane protein
DI291_RS07315	COG3401	FG-GAP repeat protein
DI291_RS07325	COG2755	lipolytic protein G-D-S-L family
DI291_RS07330	COG3401	FG-GAP repeat protein
DI291_RS07335	COG0667	Aldo Keto reductase
DI291_RS07340	COG2755	lipolytic protein G-D-S-L family
DI291_RS07345	COG1874	Beta-galactosidase
DI291_RS07355	COG1653	transport
DI291_RS07360	COG4209	transmembrane transport
DI291_RS07365	COG0395	ABC-type sugar transport system, permease component
DI291_RS07370	COG0531	amino acid
DI291_RS07375	COG0346	lactoylglutathione lyase activity
DI291_RS07380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DI291_RS07385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DI291_RS07390	COG2362	D-Aminopeptidase
DI291_RS07395	COG0601	transmembrane transport
DI291_RS07400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_RS07405	COG0444	Belongs to the ABC transporter superfamily
DI291_RS07410	COG4166	transmembrane transport
DI291_RS07415	COG1619	proteins homologs of microcin C7 resistance protein MccF
DI291_RS07420	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_RS07425	COG0791	NLP P60 protein
DI291_RS07430	COG4608	Belongs to the ABC transporter superfamily
DI291_RS07435	COG1834	amidinotransferase
DI291_RS07440	COG1607	acyl-coa hydrolase
DI291_RS07445	COG2323	membrane
DI291_RS07450	COG3866	Pectate lyase
DI291_RS07470	COG2318	DinB family
DI291_RS07475	COG2076	Multidrug Resistance protein
DI291_RS07480	COG2076	Multidrug Resistance protein
DI291_RS07485	COG0788	formyltetrahydrofolate deformylase activity
DI291_RS07490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DI291_RS07495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DI291_RS07500	COG1764	response to oxidative stress
DI291_RS07505	COG1846	Transcriptional regulator
DI291_RS07510	COG1764	response to oxidative stress
DI291_RS07520	COG0590	tRNA wobble adenosine to inosine editing
DI291_RS07525	COG0406	alpha-ribazole phosphatase activity
DI291_RS07540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DI291_RS07545	COG1404	Belongs to the peptidase S8 family
DI291_RS07555	COG2239	Acts as a magnesium transporter
DI291_RS07565	COG0789	Transcriptional regulator
DI291_RS07580	COG1846	Transcriptional regulator
DI291_RS07585	COG1793	dna ligase
DI291_RS07585	COG3285	dna ligase
DI291_RS07590	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DI291_RS07595	COG3300	MHYT domain
DI291_RS07595	COG5001	Diguanylate cyclase
DI291_RS07600	COG0586	Pfam SNARE associated Golgi protein
DI291_RS07605	COG0861	Integral membrane protein TerC family
DI291_RS07610	COG1191	sigma factor activity
DI291_RS07630	COG0501	Belongs to the peptidase M48B family
DI291_RS07635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DI291_RS07640	COG0768	penicillin binding
DI291_RS07655	COG3594	Acyltransferase
DI291_RS07660	COG5002	protein histidine kinase activity
DI291_RS07665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DI291_RS07670	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DI291_RS07675	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DI291_RS07680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DI291_RS07685	COG0436	Aminotransferase
DI291_RS07690	COG1850	ribulose-bisphosphate carboxylase activity
DI291_RS07695	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DI291_RS07695	COG0235	Class ii aldolase
DI291_RS07700	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DI291_RS07700	COG0235	Class ii aldolase
DI291_RS07705	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DI291_RS07710	COG0346	lactoylglutathione lyase activity
DI291_RS07715	COG3339	Conserved Protein
DI291_RS07725	COG3852	Histidine kinase
DI291_RS07730	COG1846	Transcriptional regulator
DI291_RS07735	COG1360	Flagellar Motor Protein
DI291_RS07740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DI291_RS07745	COG0542	response to heat
DI291_RS07750	COG3949	Membrane
DI291_RS07755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DI291_RS07760	COG0720	synthase
DI291_RS07765	COG0602	queuosine metabolic process
DI291_RS07770	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DI291_RS07790	COG1793	dna ligase
DI291_RS07805	COG3739	integral membrane protein
DI291_RS07810	COG3655	Transcriptional regulator
DI291_RS07845	COG4873	Protein conserved in bacteria
DI291_RS07855	COG3773	Cell wall hydrolase
DI291_RS07860	COG2244	polysaccharide biosynthetic process
DI291_RS07865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS07870	COG2217	Heavy metal translocating P-type atpase
DI291_RS07875	COG0006	proline dipeptidase activity
DI291_RS07885	COG1609	Transcriptional regulator
DI291_RS07890	COG3711	transcriptional antiterminator
DI291_RS07895	COG1263	PTS System
DI291_RS07895	COG2190	(PTS) system
DI291_RS07895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS07900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS07905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DI291_RS07915	COG1533	DNA photolyase activity
DI291_RS07920	COG0456	acetyltransferase
DI291_RS07925	COG0840	transmembrane signaling receptor activity
DI291_RS07930	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS07935	COG2084	Dehydrogenase
DI291_RS07940	COG2340	Cysteine-rich secretory protein family
DI291_RS07945	COG0768	penicillin binding
DI291_RS07950	COG4191	Histidine kinase
DI291_RS07955	COG0436	Aminotransferase
DI291_RS07965	COG1714	RDD family
DI291_RS07975	COG0784	Response regulator, receiver
DI291_RS07975	COG0835	chemotaxis
DI291_RS07985	COG2814	Major facilitator Superfamily
DI291_RS07990	COG1376	ErfK ybiS ycfS ynhG family protein
DI291_RS07995	COG1408	metallophosphoesterase
DI291_RS08000	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS08005	COG2200	EAL domain
DI291_RS08015	COG4703	Protein of unknown function (DUF1797)
DI291_RS08025	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DI291_RS08035	COG0517	IMP dehydrogenase activity
DI291_RS08040	COG0583	DNA-binding transcription factor activity
DI291_RS08045	COG0716	FMN binding
DI291_RS08055	COG0716	FMN binding
DI291_RS08060	COG2171	N-acyltransferase activity
DI291_RS08065	COG1473	amidohydrolase
DI291_RS08075	COG0450	alkyl hydroperoxide reductase
DI291_RS08080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS08095	COG0746	molybdenum cofactor guanylyltransferase activity
DI291_RS08100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DI291_RS08105	COG0303	'Molybdopterin
DI291_RS08110	COG1763	Mo-molybdopterin cofactor biosynthetic process
DI291_RS08115	COG0314	molybdopterin synthase activity
DI291_RS08120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DI291_RS08130	COG1132	(ABC) transporter
DI291_RS08135	COG1132	(ABC) transporter
DI291_RS08145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DI291_RS08150	COG1136	(ABC) transporter
DI291_RS08155	COG0577	efflux transmembrane transporter activity
DI291_RS08160	COG1349	DNA-binding transcription factor activity
DI291_RS08165	COG1105	Belongs to the carbohydrate kinase PfkB family
DI291_RS08170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_RS08170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS08170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_RS08190	COG0488	(ABC) transporter
DI291_RS08200	COG2309	aminopeptidase activity
DI291_RS08210	COG1077	Cell shape determining protein MreB Mrl
DI291_RS08215	COG2002	toxin-antitoxin pair type II binding
DI291_RS08220	COG3852	Histidine kinase
DI291_RS08225	COG0569	domain protein
DI291_RS08230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DI291_RS08235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DI291_RS08240	COG5503	Protein of unknown function (DUF1447)
DI291_RS08245	COG0561	phosphatase activity
DI291_RS08250	COG0242	peptide deformylase activity
DI291_RS08260	COG0497	DNA recombination
DI291_RS08265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DI291_RS08270	COG0022	dehydrogenase e1 component
DI291_RS08275	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI291_RS08280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DI291_RS08285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS08295	COG1982	Orn Lys Arg decarboxylase major
DI291_RS08300	COG4476	Belongs to the UPF0223 family
DI291_RS08305	COG4493	Belongs to the UPF0637 family
DI291_RS08315	COG0483	inositol monophosphate 1-phosphatase activity
DI291_RS08335	COG1595	DNA-templated transcription, initiation
DI291_RS08350	COG1217	gtp-binding protein TYPA
DI291_RS08360	COG1846	Transcriptional regulator
DI291_RS08365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DI291_RS08370	COG4896	Protein conserved in bacteria
DI291_RS08380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DI291_RS08385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DI291_RS08390	COG2066	Belongs to the glutaminase family
DI291_RS08395	COG4838	Belongs to the UPF0358 family
DI291_RS08400	COG0772	Belongs to the SEDS family
DI291_RS08405	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DI291_RS08410	COG1612	heme a metabolic process
DI291_RS08415	COG0109	protoheme IX farnesyltransferase activity
DI291_RS08420	COG2010	Cytochrome c
DI291_RS08420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DI291_RS08425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DI291_RS08430	COG1845	cytochrome c oxidase, subunit III
DI291_RS08435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DI291_RS08440	COG3336	cytochrome c oxidase
DI291_RS08450	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DI291_RS08455	COG2340	Cysteine-rich secretory protein family
DI291_RS08470	COG3679	Belongs to the UPF0342 family
DI291_RS08475	COG4471	UPF0298 protein
DI291_RS08480	COG0742	ribosomal rna small subunit methyltransferase
DI291_RS08485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DI291_RS08490	COG3314	Sporulation integral membrane protein YlbJ
DI291_RS08495	COG3480	Lon protease (S16) C-terminal proteolytic domain
DI291_RS08500	COG1323	Belongs to the UPF0348 family
DI291_RS08505	COG1399	metal-binding, possibly nucleic acid-binding protein
DI291_RS08510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DI291_RS08520	COG0454	-acetyltransferase
DI291_RS08525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DI291_RS08530	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DI291_RS08535	COG2001	Belongs to the MraZ family
DI291_RS08540	COG0275	rRNA processing
DI291_RS08545	COG4839	cell division protein FtsL
DI291_RS08550	COG0768	penicillin binding
DI291_RS08555	COG0768	penicillin binding
DI291_RS08560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DI291_RS08565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DI291_RS08570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DI291_RS08575	COG0772	Belongs to the SEDS family
DI291_RS08580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI291_RS08585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DI291_RS08590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DI291_RS08595	COG3879	Bacterial protein of unknown function (DUF881)
DI291_RS08600	COG3879	Bacterial protein of unknown function (DUF881)
DI291_RS08605	COG3856	small basic protein
DI291_RS08610	COG0849	cell division
DI291_RS08615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DI291_RS08620	COG4412	M6 family metalloprotease domain protein
DI291_RS08620	COG1404	Belongs to the peptidase S8 family
DI291_RS08625	COG1404	Belongs to the peptidase S8 family
DI291_RS08625	COG4412	M6 family metalloprotease domain protein
DI291_RS08635	COG1191	sigma factor activity
DI291_RS08640	COG1191	sigma factor activity
DI291_RS08645	COG1119	ATPase activity
DI291_RS08650	COG0500	methyltransferase
DI291_RS08655	COG1873	PFAM PRC-barrel domain
DI291_RS08660	COG1496	oxidoreductase activity
DI291_RS08665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DI291_RS08670	COG1799	cell septum assembly
DI291_RS08675	COG0762	integral membrane protein
DI291_RS08680	COG2302	S4 RNA-binding domain
DI291_RS08685	COG3599	regulation of cell shape
DI291_RS08690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DI291_RS08695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DI291_RS08700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DI291_RS08705	COG0564	pseudouridine synthase activity
DI291_RS08715	COG2233	PERMEase
DI291_RS08720	COG0540	Belongs to the ATCase OTCase family
DI291_RS08725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DI291_RS08730	COG0505	Belongs to the CarA family
DI291_RS08735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DI291_RS08740	COG0543	2 iron, 2 sulfur cluster binding
DI291_RS08745	COG0167	dihydroorotate dehydrogenase activity
DI291_RS08750	COG0284	orotidine-5'-phosphate decarboxylase activity
DI291_RS08755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DI291_RS08765	COG0175	sulfate reduction
DI291_RS08770	COG0306	phosphate transporter
DI291_RS08775	COG2046	Belongs to the sulfate adenylyltransferase family
DI291_RS08780	COG0529	Catalyzes the synthesis of activated sulfate
DI291_RS08785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DI291_RS08790	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DI291_RS08795	COG1648	precorrin-2 dehydrogenase activity
DI291_RS08805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DI291_RS08810	COG1561	YicC-like family, N-terminal region
DI291_RS08815	COG2052	Domain of unknown function (DUF370)
DI291_RS08820	COG0194	GDP metabolic process
DI291_RS08825	COG1758	RNA polymerase activity
DI291_RS08830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DI291_RS08835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DI291_RS08840	COG0242	peptide deformylase activity
DI291_RS08845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DI291_RS08850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DI291_RS08850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DI291_RS08855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DI291_RS08860	COG0631	protein serine/threonine phosphatase activity
DI291_RS08865	COG2815	serine threonine protein kinase
DI291_RS08865	COG0515	serine threonine protein kinase
DI291_RS08870	COG1162	GTPase activity
DI291_RS08875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DI291_RS08880	COG1564	THIamine pyrophosphokinase
DI291_RS08890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DI291_RS08895	COG1302	Protein conserved in bacteria
DI291_RS08900	COG1461	Dihydroxyacetone kinase
DI291_RS08905	COG1760	l-serine dehydratase
DI291_RS08910	COG1760	l-serine dehydratase
DI291_RS08915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DI291_RS08920	COG1349	DNA-binding transcription factor activity
DI291_RS08925	COG0416	fatty acid biosynthetic process
DI291_RS08930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DI291_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DI291_RS08945	COG0571	ribonuclease III activity
DI291_RS08950	COG1196	nuclear chromosome segregation
DI291_RS08955	COG0552	protein localization to endoplasmic reticulum
DI291_RS08960	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DI291_RS08965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DI291_RS08970	COG0228	four-way junction DNA binding
DI291_RS08975	COG1837	Belongs to the UPF0109 family
DI291_RS08985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DI291_RS08990	COG0336	Belongs to the RNA methyltransferase TrmD family
DI291_RS08995	COG0335	large ribosomal subunit rRNA binding
DI291_RS09000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DI291_RS09005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DI291_RS09015	COG2257	FlhB HrpN YscU SpaS Family
DI291_RS09020	COG0045	succinate-CoA ligase (ADP-forming) activity
DI291_RS09025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DI291_RS09030	COG0758	DNA mediated transformation
DI291_RS09035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DI291_RS09040	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DI291_RS09045	COG4974	Belongs to the 'phage' integrase family
DI291_RS09050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DI291_RS09055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DI291_RS09060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DI291_RS09065	COG1815	bacterial-type flagellum-dependent cell motility
DI291_RS09070	COG1558	bacterial-type flagellum-dependent cell motility
DI291_RS09075	COG1677	Flagellar hook-basal body complex protein FliE
DI291_RS09080	COG1766	The M ring may be actively involved in energy transduction
DI291_RS09085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DI291_RS09090	COG1317	bacterial-type flagellum organization
DI291_RS09095	COG1157	protein secretion by the type III secretion system
DI291_RS09100	COG2882	bacterial-type flagellum organization
DI291_RS09105	COG3334	PFAM MgtE intracellular
DI291_RS09110	COG3144	bacterial-type flagellum assembly
DI291_RS09115	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DI291_RS09120	COG4786	Flagellar basal body rod
DI291_RS09125	COG1582	Flagellar protein (FlbD)
DI291_RS09130	COG1580	Controls the rotational direction of flagella during chemotaxis
DI291_RS09135	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DI291_RS09140	COG1776	CheC inhibitor of MCP methylation
DI291_RS09140	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DI291_RS09145	COG2201	protein-glutamate methylesterase activity
DI291_RS09150	COG3190	flagellar
DI291_RS09155	COG1338	Plays a role in the flagellum-specific transport system
DI291_RS09160	COG1987	bacterial-type flagellum assembly
DI291_RS09165	COG1684	flagellar biosynthetic protein fliR
DI291_RS09170	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DI291_RS09175	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DI291_RS09180	COG1419	protein localization to endoplasmic reticulum
DI291_RS09185	COG0455	bacterial-type flagellum organization
DI291_RS09190	COG2201	protein-glutamate methylesterase activity
DI291_RS09195	COG0643	Histidine kinase
DI291_RS09195	COG2198	Histidine kinase
DI291_RS09200	COG0835	chemotaxis
DI291_RS09205	COG1776	CheC inhibitor of MCP methylation
DI291_RS09210	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DI291_RS09215	COG1191	sigma factor activity
DI291_RS09225	COG0052	Belongs to the universal ribosomal protein uS2 family
DI291_RS09230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DI291_RS09235	COG0528	UMP kinase activity
DI291_RS09240	COG0233	cytoplasmic translational termination
DI291_RS09245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DI291_RS09250	COG4589	Belongs to the CDS family
DI291_RS09255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DI291_RS09260	COG0750	zinc metalloprotease
DI291_RS09265	COG0442	prolyl-tRNA aminoacylation
DI291_RS09270	COG2176	DNA-directed DNA polymerase activity
DI291_RS09295	COG0779	Required for maturation of 30S ribosomal subunits
DI291_RS09300	COG0195	Participates in both transcription termination and antitermination
DI291_RS09305	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DI291_RS09310	COG1358	cellular component organization or biogenesis
DI291_RS09315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DI291_RS09320	COG1550	Protein conserved in bacteria
DI291_RS09325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DI291_RS09330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DI291_RS09335	COG0196	riboflavin kinase activity
DI291_RS09340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DI291_RS09345	COG1185	polyribonucleotide nucleotidyltransferase activity
DI291_RS09350	COG0726	polysaccharide deacetylase
DI291_RS09355	COG0612	Peptidase, M16
DI291_RS09360	COG1873	PFAM PRC-barrel domain
DI291_RS09365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DI291_RS09370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DI291_RS09375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DI291_RS09380	COG0527	aspartate kinase activity
DI291_RS09390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DI291_RS09395	COG0740	serine-type endopeptidase activity
DI291_RS09405	COG4980	gas vesicle protein
DI291_RS09405	COG1674	ftsk spoiiie
DI291_RS09410	COG2188	Transcriptional regulator
DI291_RS09415	COG2814	Major facilitator Superfamily
DI291_RS09420	COG0612	Peptidase, M16
DI291_RS09425	COG0612	Peptidase, M16
DI291_RS09430	COG0300	oxidoreductase activity
DI291_RS09445	COG1426	Protein conserved in bacteria
DI291_RS09450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DI291_RS09455	COG1546	Belongs to the CinA family
DI291_RS09455	COG1058	Belongs to the CinA family
DI291_RS09465	COG1418	mRNA catabolic process
DI291_RS09470	COG1692	metallophosphoesterase
DI291_RS09475	COG2359	stage V sporulation protein S
DI291_RS09485	COG1063	alcohol dehydrogenase
DI291_RS09495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DI291_RS09500	COG4550	Control of competence regulator ComK, YlbF/YmcA
DI291_RS09510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DI291_RS09515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DI291_RS09520	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DI291_RS09525	COG0457	Tetratricopeptide repeat
DI291_RS09545	COG0457	Tetratricopeptide repeat
DI291_RS09560	COG0523	cobalamin synthesis protein
DI291_RS09580	COG1231	oxidoreductase activity
DI291_RS09585	COG3619	membrane
DI291_RS09590	COG3263	regulation of cellular component size
DI291_RS09595	COG2814	Major facilitator Superfamily
DI291_RS09605	COG0393	Putative heavy-metal-binding
DI291_RS09610	COG0398	Pfam SNARE associated Golgi protein
DI291_RS09615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI291_RS09620	COG1819	glycosyl
DI291_RS09625	COG0531	amino acid
DI291_RS09630	COG5577	PFAM Coat F domain
DI291_RS09640	COG3858	chitin binding
DI291_RS09640	COG1388	LysM domain
DI291_RS09645	COG1309	transcriptional regulator
DI291_RS09650	COG3631	Ketosteroid isomerase-related protein
DI291_RS09655	COG0702	epimerase
DI291_RS09665	COG1764	response to oxidative stress
DI291_RS09670	COG2076	Multidrug Resistance protein
DI291_RS09675	COG2076	Multidrug Resistance protein
DI291_RS09690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DI291_RS09695	COG1923	regulation of RNA biosynthetic process
DI291_RS09705	COG1780	Probably involved in ribonucleotide reductase function
DI291_RS09710	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DI291_RS09715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DI291_RS09720	COG4112	unkown
DI291_RS09735	COG0735	belongs to the Fur family
DI291_RS09740	COG1802	Transcriptional regulator
DI291_RS09745	COG0697	spore germination
DI291_RS09775	COG1309	transcriptional regulator
DI291_RS09810	COG4282	regulation of fungal-type cell wall biogenesis
DI291_RS09815	COG5444	nuclease activity
DI291_RS09860	COG2814	Major facilitator Superfamily
DI291_RS09865	COG0457	Tetratricopeptide repeat
DI291_RS09875	COG4413	Urea transporter
DI291_RS09880	COG0831	urea catabolic process
DI291_RS09885	COG0832	Belongs to the urease beta subunit family
DI291_RS09895	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DI291_RS09900	COG0830	nickel cation binding
DI291_RS09905	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DI291_RS09910	COG0829	nickel cation binding
DI291_RS09920	COG1695	Transcriptional regulator
DI291_RS09935	COG0464	growth
DI291_RS09940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DI291_RS09945	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DI291_RS09950	COG0789	Transcriptional regulator
DI291_RS09955	COG0174	glutamine synthetase
DI291_RS10020	COG1073	alpha beta
DI291_RS10060	COG1309	transcriptional regulator
DI291_RS10065	COG2076	Multidrug Resistance protein
DI291_RS10070	COG2076	Multidrug Resistance protein
DI291_RS10075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_RS10090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS10095	COG3546	catalase activity
DI291_RS10120	COG1846	Transcriptional regulator
DI291_RS10125	COG0346	lactoylglutathione lyase activity
DI291_RS10130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DI291_RS10135	COG0655	NAD(P)H dehydrogenase (quinone) activity
DI291_RS10160	COG3209	COG3209 Rhs family protein
DI291_RS10165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DI291_RS10170	COG1388	LysM domain
DI291_RS10175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DI291_RS10180	COG4224	UPF0291 protein
DI291_RS10185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DI291_RS10195	COG3763	UPF0154 protein
DI291_RS10205	COG0785	Cytochrome C biogenesis protein
DI291_RS10210	COG2201	protein-glutamate methylesterase activity
DI291_RS10215	COG4846	Membrane protein involved in cytochrome C biogenesis
DI291_RS10225	COG0071	Belongs to the small heat shock protein (HSP20) family
DI291_RS10240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DI291_RS10245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS10265	COG0824	Thioesterase
DI291_RS10285	COG4841	protein insertion into membrane
DI291_RS10290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DI291_RS10295	COG1832	CoA-binding protein
DI291_RS10300	COG0187	DNA topoisomerase II activity
DI291_RS10305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DI291_RS10310	COG1609	Transcriptional regulator
DI291_RS10325	COG2160	L-arabinose isomerase activity
DI291_RS10345	COG1115	amino acid carrier protein
DI291_RS10355	COG2181	nitrate reductase activity
DI291_RS10360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DI291_RS10365	COG1140	nitrate reductase beta subunit
DI291_RS10370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DI291_RS10385	COG0535	radical SAM domain protein
DI291_RS10390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DI291_RS10400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DI291_RS10405	COG2223	nitrite transmembrane transporter activity
DI291_RS10425	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DI291_RS10435	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DI291_RS10445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_RS10460	COG0477	Major facilitator Superfamily
DI291_RS10465	COG3420	alginic acid biosynthetic process
DI291_RS10470	COG1114	Component of the transport system for branched-chain amino acids
DI291_RS10495	COG1024	Enoyl-CoA hydratase
DI291_RS10500	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS10505	COG2084	Dehydrogenase
DI291_RS10510	COG1960	acyl-CoA dehydrogenase activity
DI291_RS10515	COG1482	cell wall glycoprotein biosynthetic process
DI291_RS10520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_RS10520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS10520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_RS10535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS10535	COG3711	transcriptional antiterminator
DI291_RS10550	COG1725	Transcriptional regulator
DI291_RS10555	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS10560	COG1312	Catalyzes the dehydration of D-mannonate
DI291_RS10575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DI291_RS10585	COG1609	Transcriptional regulator
DI291_RS10590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DI291_RS10595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DI291_RS10600	COG0640	Transcriptional regulator
DI291_RS10605	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DI291_RS10620	COG1649	PFAM Uncharacterised BCR, COG1649
DI291_RS10625	COG2404	hydrolase activity, acting on ester bonds
DI291_RS10630	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DI291_RS10640	COG0438	transferase activity, transferring glycosyl groups
DI291_RS10645	COG2027	D-alanyl-D-alanine carboxypeptidase
DI291_RS10665	COG1309	transcriptional regulator
DI291_RS10670	COG1252	NADH dehydrogenase
DI291_RS10680	COG0166	Belongs to the GPI family
DI291_RS10690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DI291_RS10695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DI291_RS10700	COG1024	Enoyl-CoA hydratase
DI291_RS10705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DI291_RS10710	COG0511	ligase activity, forming carbon-carbon bonds
DI291_RS10715	COG0439	Biotin carboxylase
DI291_RS10720	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DI291_RS10720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS10725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS10730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS10735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS10740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS10745	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_RS10750	COG1960	acyl-CoA dehydrogenase activity
DI291_RS10755	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_RS10760	COG1733	regulation of RNA biosynthetic process
DI291_RS10765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DI291_RS10770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DI291_RS10780	COG2323	membrane
DI291_RS10785	COG0306	phosphate transporter
DI291_RS10790	COG0175	sulfate reduction
DI291_RS10795	COG1809	phosphosulfolactate synthase activity
DI291_RS10800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_RS10805	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_RS10810	COG2814	Major facilitator Superfamily
DI291_RS10815	COG0463	Glycosyl transferase, family 2
DI291_RS10830	COG0493	'glutamate synthase
DI291_RS10835	COG0067	glutamate synthase
DI291_RS10835	COG0069	glutamate synthase activity
DI291_RS10835	COG0070	glutamate synthase
DI291_RS10840	COG0583	DNA-binding transcription factor activity
DI291_RS10870	COG1132	(ABC) transporter
DI291_RS10880	COG0300	oxidoreductase activity
DI291_RS10885	COG0574	Belongs to the PEP-utilizing enzyme family
DI291_RS10885	COG3848	Pyruvate phosphate dikinase
DI291_RS10890	COG0477	Major facilitator Superfamily
DI291_RS10895	COG0243	molybdopterin cofactor binding
DI291_RS10900	COG1846	Transcriptional regulator
DI291_RS10905	COG2814	Major facilitator Superfamily
DI291_RS10910	COG0531	amino acid
DI291_RS10920	COG0531	amino acid
DI291_RS10925	COG0531	amino acid
DI291_RS10930	COG0697	spore germination
DI291_RS10935	COG0488	(ABC) transporter
DI291_RS10940	COG0840	transmembrane signaling receptor activity
DI291_RS10945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_RS10950	COG1404	Belongs to the peptidase S8 family
DI291_RS10960	COG1309	transcriptional regulator
DI291_RS10965	COG1846	Transcriptional regulator
DI291_RS10995	COG1309	transcriptional regulator
DI291_RS11000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_RS11005	COG3708	Transcriptional regulator
DI291_RS11015	COG2378	regulation of single-species biofilm formation
DI291_RS11025	COG0640	Transcriptional regulator
DI291_RS11040	COG0531	amino acid
DI291_RS11045	COG0741	lytic transglycosylase activity
DI291_RS11050	COG1086	Polysaccharide biosynthesis protein
DI291_RS11065	COG0438	transferase activity, transferring glycosyl groups
DI291_RS11070	COG2322	membrane
DI291_RS11085	COG1619	proteins homologs of microcin C7 resistance protein MccF
DI291_RS11090	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_RS11095	COG3584	3D domain protein
DI291_RS11095	COG1388	LysM domain
DI291_RS11100	COG0514	ATP-dependent DNA helicase (RecQ)
DI291_RS11120	COG2315	Protein conserved in bacteria
DI291_RS11125	COG5444	nuclease activity
DI291_RS11130	COG2427	Protein of unknown function (DUF1641)
DI291_RS11135	COG3383	formate dehydrogenase (NAD+) activity
DI291_RS11180	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DI291_RS11200	COG2350	Protein conserved in bacteria
DI291_RS11225	COG0402	S-adenosylhomocysteine deaminase activity
DI291_RS11240	COG2267	carboxylic ester hydrolase activity
DI291_RS11255	COG1280	lysine exporter protein (LysE YggA)
DI291_RS11260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DI291_RS11270	COG0574	Belongs to the PEP-utilizing enzyme family
DI291_RS11270	COG3848	Pyruvate phosphate dikinase
DI291_RS11290	COG2318	DinB family
DI291_RS11295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DI291_RS11315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DI291_RS11330	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS11350	COG1657	PFAM Prenyltransferase squalene oxidase
DI291_RS11355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DI291_RS11365	COG0733	neurotransmitter:sodium symporter activity
DI291_RS11370	COG0385	Bile acid
DI291_RS11375	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI291_RS11380	COG0567	Dehydrogenase, E1 component
DI291_RS11385	COG4548	von Willebrand factor, type A
DI291_RS11390	COG0714	Associated with various cellular activities
DI291_RS11395	COG2032	superoxide dismutase activity
DI291_RS11400	COG0791	NLP P60 protein
DI291_RS11400	COG1388	LysM domain
DI291_RS11405	COG0534	Mate efflux family protein
DI291_RS11410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DI291_RS11415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DI291_RS11425	COG2962	Rard protein
DI291_RS11435	COG4305	rare lipoprotein A
DI291_RS11445	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS11450	COG1733	regulation of RNA biosynthetic process
DI291_RS11455	COG0778	Nitroreductase
DI291_RS11460	COG0400	carboxylic ester hydrolase activity
DI291_RS11470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_RS11475	COG0793	Belongs to the peptidase S41A family
DI291_RS11475	COG3409	Peptidoglycan-binding domain 1 protein
DI291_RS11480	COG2226	methyltransferase
DI291_RS11490	COG1876	peptidase activity
DI291_RS11495	COG0813	purine-nucleoside phosphorylase activity
DI291_RS11500	COG0701	Predicted permease
DI291_RS11520	COG0671	phosphoesterase, PA-phosphatase related
DI291_RS11535	COG4479	Belongs to the UPF0346 family
DI291_RS11545	COG1509	lysine 2,3-aminomutase activity
DI291_RS11550	COG0456	acetyltransferase
DI291_RS11555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DI291_RS11560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DI291_RS11565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DI291_RS11570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DI291_RS11585	COG0456	acetyltransferase
DI291_RS11590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DI291_RS11595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DI291_RS11600	COG1846	Transcriptional regulator
DI291_RS11610	COG3706	GGDEF domain
DI291_RS11615	COG0534	Mate efflux family protein
DI291_RS11630	COG4698	Protein conserved in bacteria
DI291_RS11635	COG2755	lipolytic protein G-D-S-L family
DI291_RS11640	COG1999	signal sequence binding
DI291_RS11655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DI291_RS11660	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DI291_RS11665	COG1272	protein, Hemolysin III
DI291_RS11670	COG0204	Acyl-transferase
DI291_RS11675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DI291_RS11680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DI291_RS11690	COG2521	methyltransferase
DI291_RS11690	COG2136	Putative SAM-dependent methyltransferase
DI291_RS11700	COG0129	dihydroxy-acid dehydratase activity
DI291_RS11705	COG1413	lyase activity
DI291_RS11710	COG1418	mRNA catabolic process
DI291_RS11715	COG0386	Belongs to the glutathione peroxidase family
DI291_RS11720	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DI291_RS11725	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DI291_RS11730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI291_RS11740	COG1278	Cold shock
DI291_RS11760	COG0328	RNA-DNA hybrid ribonuclease activity
DI291_RS11765	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DI291_RS11770	COG0328	RNA-DNA hybrid ribonuclease activity
DI291_RS11780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DI291_RS11795	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DI291_RS11805	COG1755	Isoprenylcysteine carboxyl methyltransferase
DI291_RS11810	COG3424	synthase
DI291_RS11820	COG2233	PERMEase
DI291_RS11825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DI291_RS11830	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DI291_RS11835	COG1199	ATP-dependent helicase activity
DI291_RS11860	COG0116	Belongs to the methyltransferase superfamily
DI291_RS11870	COG3599	regulation of cell shape
DI291_RS11875	COG4474	Belongs to the UPF0398 family
DI291_RS11885	COG3359	exonuclease
DI291_RS11890	COG1111	helicase
DI291_RS11890	COG1205	dead DEAH box helicase
DI291_RS11895	COG2190	(PTS) system
DI291_RS11900	COG0071	Belongs to the small heat shock protein (HSP20) family
DI291_RS11935	COG3331	DNA recombination
DI291_RS11940	COG4499	WXG100 protein secretion system (Wss), protein YukC
DI291_RS11940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DI291_RS11950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DI291_RS11955	COG3935	DnaD domain protein
DI291_RS11960	COG0017	Asparaginyl-tRNA synthetase
DI291_RS11965	COG0436	Aminotransferase
DI291_RS11970	COG5353	protein conserved in bacteria
DI291_RS11980	COG1199	ATP-dependent helicase activity
DI291_RS11980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DI291_RS11985	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DI291_RS11990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DI291_RS11995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DI291_RS12005	COG0617	tRNA 3'-terminal CCA addition
DI291_RS12010	COG0438	transferase activity, transferring glycosyl groups
DI291_RS12015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DI291_RS12020	COG1803	Methylglyoxal synthase
DI291_RS12025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DI291_RS12030	COG1694	Mazg nucleotide pyrophosphohydrolase
DI291_RS12035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_RS12045	COG4347	Protein of unknown function (DUF1405)
DI291_RS12055	COG2010	Cytochrome c
DI291_RS12055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DI291_RS12060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DI291_RS12065	COG0723	plastoquinol--plastocyanin reductase activity
DI291_RS12075	COG5582	Belongs to the UPF0302 family
DI291_RS12080	COG0457	Tetratricopeptide repeat
DI291_RS12085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DI291_RS12090	COG0287	Prephenate dehydrogenase
DI291_RS12095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DI291_RS12100	COG0159	tryptophan synthase activity
DI291_RS12105	COG0133	tryptophan synthase activity
DI291_RS12110	COG0135	phosphoribosylanthranilate isomerase activity
DI291_RS12115	COG0134	indole-3-glycerol-phosphate synthase activity
DI291_RS12120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DI291_RS12125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DI291_RS12130	COG4401	Chorismate mutase type I
DI291_RS12135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DI291_RS12140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DI291_RS12145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DI291_RS12150	COG0105	UTP biosynthetic process
DI291_RS12155	COG0142	geranyltranstransferase activity
DI291_RS12160	COG2226	methyltransferase
DI291_RS12165	COG0142	geranyltranstransferase activity
DI291_RS12180	COG0776	regulation of translation
DI291_RS12185	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DI291_RS12200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DI291_RS12205	COG1160	GTP binding
DI291_RS12230	COG1304	FMN binding
DI291_RS12235	COG0539	negative regulation of cytoplasmic translation
DI291_RS12240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DI291_RS12250	COG2959	enzyme of heme biosynthesis
DI291_RS12255	COG3409	Peptidoglycan-binding domain 1 protein
DI291_RS12255	COG3773	Cell wall hydrolase
DI291_RS12260	COG2339	peptidase activity
DI291_RS12270	COG0492	ferredoxin-NADP+ reductase activity
DI291_RS12275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DI291_RS12280	COG4862	establishment of competence for transformation
DI291_RS12285	COG1408	metallophosphoesterase
DI291_RS12295	COG1388	LysM domain
DI291_RS12300	COG1266	CAAX protease self-immunity
DI291_RS12305	COG0514	ATP-dependent DNA helicase (RecQ)
DI291_RS12310	COG4955	Helix-turn-helix domain
DI291_RS12315	COG1141	Ferredoxin
DI291_RS12320	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DI291_RS12325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DI291_RS12330	COG0739	heme binding
DI291_RS12340	COG1595	DNA-templated transcription, initiation
DI291_RS12345	COG1316	TRANSCRIPTIONal
DI291_RS12360	COG5002	protein histidine kinase activity
DI291_RS12365	COG0745	RESPONSE REGULATOR receiver
DI291_RS12370	COG5002	protein histidine kinase activity
DI291_RS12375	COG0745	RESPONSE REGULATOR receiver
DI291_RS12380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DI291_RS12385	COG1333	cytochrome c biogenesis protein
DI291_RS12390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS12395	COG1187	pseudouridine synthase activity
DI291_RS12400	COG0700	Nucleoside recognition
DI291_RS12405	COG2715	membrane protein required for spore maturation
DI291_RS12410	COG1686	Belongs to the peptidase S11 family
DI291_RS12420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DI291_RS12425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DI291_RS12435	COG1547	Domain of unknown function (DUF309)
DI291_RS12440	COG0456	acetyltransferase
DI291_RS12445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DI291_RS12450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DI291_RS12450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DI291_RS12455	COG0307	riboflavin synthase, alpha
DI291_RS12460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DI291_RS12460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DI291_RS12480	COG0457	Tetratricopeptide repeat
DI291_RS12485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DI291_RS12490	COG4086	secreted protein
DI291_RS12495	COG4195	phage-related replication protein
DI291_RS12500	COG0019	diaminopimelate decarboxylase activity
DI291_RS12510	COG0697	spore germination
DI291_RS12525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI291_RS12560	COG1686	Belongs to the peptidase S11 family
DI291_RS12565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DI291_RS12570	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DI291_RS12575	COG4974	Belongs to the 'phage' integrase family
DI291_RS12585	COG0735	belongs to the Fur family
DI291_RS12590	COG1300	Membrane
DI291_RS12595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_RS12605	COG1953	Uracil, thiamine, allantoin
DI291_RS12620	COG2153	protein acetylation
DI291_RS12625	COG1379	DNA repair
DI291_RS12630	COG0494	nUDIX hydrolase
DI291_RS12640	COG1309	transcriptional regulator
DI291_RS12650	COG0667	Aldo Keto reductase
DI291_RS12660	COG1073	alpha beta
DI291_RS12670	COG4918	Iron-sulphur cluster biosynthesis
DI291_RS12680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DI291_RS12680	COG0456	acetyltransferase
DI291_RS12685	COG2329	Antibiotic biosynthesis monooxygenase
DI291_RS12690	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DI291_RS12700	COG0747	negative chemotaxis
DI291_RS12705	COG0601	transmembrane transport
DI291_RS12710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_RS12715	COG0444	Belongs to the ABC transporter superfamily
DI291_RS12725	COG0534	Mate efflux family protein
DI291_RS12740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DI291_RS12750	COG2211	Major facilitator Superfamily
DI291_RS12755	COG0346	lactoylglutathione lyase activity
DI291_RS12760	COG1072	(Pantothenic acid kinase))
DI291_RS12770	COG3842	ATPase activity
DI291_RS12795	COG2205	protein histidine kinase activity
DI291_RS12800	COG0745	RESPONSE REGULATOR receiver
DI291_RS12820	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DI291_RS12825	COG2814	Major facilitator Superfamily
DI291_RS12835	COG4195	phage-related replication protein
DI291_RS12845	COG0300	oxidoreductase activity
DI291_RS12850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_RS12855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DI291_RS12860	COG4187	Peptidase family M20/M25/M40
DI291_RS12865	COG1902	pentaerythritol trinitrate reductase activity
DI291_RS12870	COG0596	Alpha beta hydrolase
DI291_RS12875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DI291_RS12880	COG1234	tRNA 3'-trailer cleavage
DI291_RS12885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DI291_RS12900	COG2358	TRAP transporter, solute receptor (TAXI family
DI291_RS12905	COG2188	Transcriptional regulator
DI291_RS12910	COG2723	6-phospho-beta-galactosidase activity
DI291_RS12915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_RS12920	COG1447	Phosphotransferase system cellobiose-specific component IIA
DI291_RS12925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_RS12930	COG1785	Belongs to the alkaline phosphatase family
DI291_RS12935	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS12940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DI291_RS12945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DI291_RS12955	COG0706	membrane insertase activity
DI291_RS12960	COG2195	Cleaves the N-terminal amino acid of tripeptides
DI291_RS12965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DI291_RS12975	COG4129	membrane
DI291_RS12980	COG1126	abc transporter atp-binding protein
DI291_RS12985	COG0765	amino acid transport
DI291_RS12990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DI291_RS13000	COG1597	lipid kinase activity
DI291_RS13005	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI291_RS13010	COG0022	dehydrogenase e1 component
DI291_RS13015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DI291_RS13020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DI291_RS13025	COG3426	butyrate kinase activity
DI291_RS13035	COG0280	phosphate acetyltransferase
DI291_RS13040	COG3829	transcription factor binding
DI291_RS13040	COG3290	protein histidine kinase activity
DI291_RS13050	COG0584	glycerophosphoryl diester phosphodiesterase
DI291_RS13055	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_RS13075	COG0745	RESPONSE REGULATOR receiver
DI291_RS13080	COG0750	zinc metalloprotease
DI291_RS13085	COG0497	DNA recombination
DI291_RS13090	COG1438	arginine binding
DI291_RS13095	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DI291_RS13100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DI291_RS13105	COG0142	geranyltranstransferase activity
DI291_RS13110	COG1722	exodeoxyribonuclease VII activity
DI291_RS13115	COG1570	exodeoxyribonuclease VII activity
DI291_RS13120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DI291_RS13125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DI291_RS13130	COG1302	Protein conserved in bacteria
DI291_RS13135	COG0439	Biotin carboxylase
DI291_RS13140	COG0511	ligase activity, forming carbon-carbon bonds
DI291_RS13180	COG3854	ATPases associated with a variety of cellular activities
DI291_RS13190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DI291_RS13195	COG0006	proline dipeptidase activity
DI291_RS13200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DI291_RS13210	COG3872	metal-dependent enzyme
DI291_RS13220	COG1752	Esterase of the alpha-beta hydrolase superfamily
DI291_RS13225	COG1321	iron dependent repressor
DI291_RS13230	COG0095	Lipoate-protein ligase
DI291_RS13235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_RS13240	COG2113	Glycine betaine
DI291_RS13245	COG4176	ABC-type proline glycine betaine transport system permease component
DI291_RS13250	COG4175	Glycine betaine
DI291_RS13250	COG0517	IMP dehydrogenase activity
DI291_RS13255	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DI291_RS13260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DI291_RS13265	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DI291_RS13270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DI291_RS13295	COG0681	Belongs to the peptidase S26 family
DI291_RS13320	COG4940	Competence protein ComGF
DI291_RS13330	COG4970	Tfp pilus assembly protein FimT
DI291_RS13335	COG4537	Required for transformation and DNA binding
DI291_RS13340	COG1459	type II secretion system
DI291_RS13345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DI291_RS13350	COG1366	Belongs to the anti-sigma-factor antagonist family
DI291_RS13360	COG1393	Belongs to the ArsC family
DI291_RS13370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_RS13380	COG0011	TIGRFAM Protein of
DI291_RS13390	COG2866	Carboxypeptidase
DI291_RS13395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_RS13400	COG1368	sulfuric ester hydrolase activity
DI291_RS13405	COG1940	carbohydrate kinase activity
DI291_RS13410	COG4483	Protein conserved in bacteria
DI291_RS13415	COG0697	spore germination
DI291_RS13420	COG0457	Tetratricopeptide repeat
DI291_RS13420	COG0705	Rhomboid family
DI291_RS13430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DI291_RS13435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DI291_RS13440	COG0438	transferase activity, transferring glycosyl groups
DI291_RS13455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DI291_RS13505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DI291_RS13510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DI291_RS13515	COG0581	inorganic phosphate transmembrane transporter activity
DI291_RS13520	COG0573	inorganic phosphate transmembrane transporter activity
DI291_RS13525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DI291_RS13530	COG0768	penicillin binding
DI291_RS13535	COG0477	Major facilitator Superfamily
DI291_RS13540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DI291_RS13545	COG2839	Protein conserved in bacteria
DI291_RS13550	COG5521	maltodextrose utilization protein MalA
DI291_RS13555	COG1388	LysM domain
DI291_RS13560	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DI291_RS13565	COG4709	membrane
DI291_RS13570	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DI291_RS13575	COG0735	belongs to the Fur family
DI291_RS13580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DI291_RS13585	COG1121	(ABC) transporter
DI291_RS13590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_RS13600	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DI291_RS13605	COG0513	Belongs to the DEAD box helicase family
DI291_RS13615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DI291_RS13620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DI291_RS13625	COG2384	SAM-dependent methyltransferase
DI291_RS13665	COG2010	Cytochrome c
DI291_RS13670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DI291_RS13675	COG0358	DNA primase activity
DI291_RS13680	COG1671	Belongs to the UPF0178 family
DI291_RS13685	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DI291_RS13690	COG0517	IMP dehydrogenase activity
DI291_RS13695	COG0751	glycine-tRNA ligase activity
DI291_RS13700	COG0752	glycyl-tRNA synthetase alpha subunit
DI291_RS13705	COG1381	Involved in DNA repair and RecF pathway recombination
DI291_RS13715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DI291_RS13720	COG0295	cytidine deaminase activity
DI291_RS13725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DI291_RS13730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DI291_RS13735	COG1480	7TM receptor with intracellular HD hydrolase
DI291_RS13740	COG1702	phosphate starvation-inducible protein PhoH
DI291_RS13745	COG0561	phosphatase activity
DI291_RS13760	COG4864	UPF0365 protein
DI291_RS13765	COG1030	water channel activity
DI291_RS13770	COG1610	YqeY-like protein
DI291_RS13775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DI291_RS13780	COG1283	sodium-dependent phosphate transmembrane transporter activity
DI291_RS13785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DI291_RS13790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DI291_RS13795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DI291_RS13800	COG2264	protein methyltransferase activity
DI291_RS13805	COG0484	heat shock protein binding
DI291_RS13810	COG0443	Heat shock 70 kDa protein
DI291_RS13815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DI291_RS13820	COG1420	regulation of RNA biosynthetic process
DI291_RS13825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DI291_RS13830	COG0481	GTPase activity
DI291_RS13840	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_RS13845	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DI291_RS13850	COG0268	Binds directly to 16S ribosomal RNA
DI291_RS13860	COG1733	regulation of RNA biosynthetic process
DI291_RS13865	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_RS13870	COG1466	dna polymerase III delta subunit
DI291_RS13880	COG0658	competence protein
DI291_RS13880	COG2333	competence protein COMEC
DI291_RS13885	COG2131	deaminase
DI291_RS13890	COG1555	photosystem II stabilization
DI291_RS13890	COG1596	polysaccharide export
DI291_RS13895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DI291_RS13900	COG2226	methyltransferase
DI291_RS13905	COG0799	negative regulation of ribosome biogenesis
DI291_RS13910	COG1713	HD superfamily hydrolase involved in NAD metabolism
DI291_RS13915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DI291_RS13920	COG1534	Rna-binding protein
DI291_RS13925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DI291_RS13930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DI291_RS13935	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DI291_RS13950	COG2755	lipolytic protein G-D-S-L family
DI291_RS13960	COG5609	conserved protein (DUF2294)
DI291_RS13965	COG3383	formate dehydrogenase (NAD+) activity
DI291_RS13970	COG2427	Protein of unknown function (DUF1641)
DI291_RS13985	COG1687	branched-chain amino acid
DI291_RS13990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DI291_RS14005	COG1309	transcriptional regulator
DI291_RS14010	COG1609	Transcriptional regulator
DI291_RS14015	COG4195	phage-related replication protein
DI291_RS14040	COG3223	Belongs to the PsiE family
DI291_RS14045	COG0642	Histidine kinase
DI291_RS14045	COG5002	protein histidine kinase activity
DI291_RS14050	COG0745	RESPONSE REGULATOR receiver
DI291_RS14055	COG2311	Membrane
DI291_RS14065	COG0454	-acetyltransferase
DI291_RS14085	COG3616	Alanine racemase, N-terminal domain
DI291_RS14090	COG0251	oxidation-reduction process
DI291_RS14100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DI291_RS14105	COG0251	oxidation-reduction process
DI291_RS14115	COG0561	phosphatase activity
DI291_RS14120	COG1486	melibiose metabolic process
DI291_RS14130	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DI291_RS14135	COG2186	Transcriptional regulator
DI291_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS14150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DI291_RS14155	COG3959	Transketolase, thiamine diphosphate binding domain
DI291_RS14165	COG4978	Transcriptional regulator
DI291_RS14165	COG0789	Transcriptional regulator
DI291_RS14200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_RS14210	COG2197	response regulator
DI291_RS14215	COG4585	Histidine kinase
DI291_RS14220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS14225	COG0730	response to heat
DI291_RS14230	COG0425	Belongs to the sulfur carrier protein TusA family
DI291_RS14235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_RS14235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_RS14240	COG0425	Belongs to the sulfur carrier protein TusA family
DI291_RS14240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_RS14245	COG2210	Belongs to the sulfur carrier protein TusA family
DI291_RS14250	COG1937	Protein conserved in bacteria
DI291_RS14265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DI291_RS14275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DI291_RS14280	COG1522	sequence-specific DNA binding
DI291_RS14295	COG1376	ErfK ybiS ycfS ynhG family protein
DI291_RS14305	COG0431	NADPH-dependent FMN reductase
DI291_RS14350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS14355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS14360	COG1120	ATPase activity
DI291_RS14365	COG0523	cobalamin synthesis protein
DI291_RS14370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DI291_RS14375	COG0113	porphobilinogen synthase activity
DI291_RS14395	COG1942	4-Oxalocrotonate Tautomerase
DI291_RS14400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DI291_RS14405	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DI291_RS14410	COG1733	regulation of RNA biosynthetic process
DI291_RS14415	COG3239	Fatty acid desaturase
DI291_RS14420	COG4585	Histidine kinase
DI291_RS14425	COG2197	response regulator
DI291_RS14430	COG0492	ferredoxin-NADP+ reductase activity
DI291_RS14435	COG0747	negative chemotaxis
DI291_RS14440	COG0601	transmembrane transport
DI291_RS14445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_RS14450	COG0444	Belongs to the ABC transporter superfamily
DI291_RS14455	COG4608	Belongs to the ABC transporter superfamily
DI291_RS14475	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS14485	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DI291_RS14500	COG2124	cytochrome p450
DI291_RS14505	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_RS14510	COG2211	Major facilitator Superfamily
DI291_RS14520	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS14525	COG1621	beta-fructofuranosidase activity
DI291_RS14530	COG3716	PTS system mannose fructose sorbose family IID component
DI291_RS14535	COG3715	PTS system
DI291_RS14540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS14545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS14550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DI291_RS14550	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DI291_RS14570	COG2169	Transcriptional regulator
DI291_RS14575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DI291_RS14580	COG2205	protein histidine kinase activity
DI291_RS14590	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DI291_RS14595	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DI291_RS14605	COG0656	L-ascorbic acid biosynthetic process
DI291_RS14610	COG2814	Major facilitator Superfamily
DI291_RS14615	COG1733	regulation of RNA biosynthetic process
DI291_RS14620	COG3340	Belongs to the peptidase S51 family
DI291_RS14625	COG1587	Uroporphyrinogen-III synthase
DI291_RS14635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_RS14640	COG0583	DNA-binding transcription factor activity
DI291_RS14645	COG2814	Major facilitator Superfamily
DI291_RS14655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DI291_RS14655	COG2124	cytochrome p450
DI291_RS14660	COG1309	transcriptional regulator
DI291_RS14665	COG1404	Belongs to the peptidase S8 family
DI291_RS14670	COG2226	methyltransferase
DI291_RS14695	COG0626	cystathionine gamma-synthase activity
DI291_RS14700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DI291_RS14705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DI291_RS14710	COG2226	methyltransferase
DI291_RS14725	COG0768	penicillin binding
DI291_RS14730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DI291_RS14735	COG0572	uridine kinase
DI291_RS14740	COG0826	peptidase U32
DI291_RS14745	COG0826	peptidase U32
DI291_RS14750	COG4122	O-methyltransferase activity
DI291_RS14755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DI291_RS14760	COG3906	Belongs to the UPF0473 family
DI291_RS14765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DI291_RS14770	COG4472	Bacterial protein of unknown function (DUF965)
DI291_RS14775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DI291_RS14780	COG0628	permease
DI291_RS14795	COG3881	PFAM PRC-barrel domain
DI291_RS14800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DI291_RS14805	COG0457	Tetratricopeptide repeat
DI291_RS14810	COG0482	sulfurtransferase activity
DI291_RS14815	COG1104	cysteine desulfurase activity
DI291_RS14820	COG1959	2 iron, 2 sulfur cluster binding
DI291_RS14825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DI291_RS14830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DI291_RS14840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DI291_RS14845	COG0124	histidyl-tRNA synthetase
DI291_RS14855	COG3103	Sh3 type 3 domain protein
DI291_RS14855	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_RS14855	COG4991	sh3 domain protein
DI291_RS14860	COG1490	D-aminoacyl-tRNA deacylase activity
DI291_RS14865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DI291_RS14870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DI291_RS14875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DI291_RS14875	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DI291_RS14880	COG5416	Lipopolysaccharide assembly protein A domain
DI291_RS14885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DI291_RS14885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DI291_RS14895	COG2244	polysaccharide biosynthetic process
DI291_RS14900	COG2323	membrane
DI291_RS14910	COG1862	Preprotein translocase
DI291_RS14915	COG0343	queuine tRNA-ribosyltransferase activity
DI291_RS14920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DI291_RS14930	COG2255	four-way junction helicase activity
DI291_RS14935	COG0632	four-way junction helicase activity
DI291_RS14945	COG2112	serine threonine protein kinase
DI291_RS14955	COG2318	DinB family
DI291_RS14960	COG4195	phage-related replication protein
DI291_RS14975	COG0217	transcriptional regulatory protein
DI291_RS14985	COG1388	LysM domain
DI291_RS14990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DI291_RS14995	COG0157	Belongs to the NadC ModD family
DI291_RS15000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DI291_RS15005	COG1104	cysteine desulfurase activity
DI291_RS15010	COG1827	regulation of RNA biosynthetic process
DI291_RS15015	COG0077	Prephenate dehydratase
DI291_RS15020	COG4492	Belongs to the UPF0735 family
DI291_RS15025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DI291_RS15030	COG3290	protein histidine kinase activity
DI291_RS15035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DI291_RS15040	COG2868	ribosomal protein
DI291_RS15045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DI291_RS15050	COG1994	Peptidase M50
DI291_RS15055	COG0739	heme binding
DI291_RS15060	COG3832	glyoxalase III activity
DI291_RS15065	COG0640	Transcriptional regulator
DI291_RS15070	COG2894	cell division
DI291_RS15075	COG0850	regulation of cytokinetic process
DI291_RS15080	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DI291_RS15090	COG1077	Cell shape determining protein MreB Mrl
DI291_RS15095	COG2003	Belongs to the UPF0758 family
DI291_RS15100	COG0424	maF-like protein
DI291_RS15110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DI291_RS15115	COG0285	dihydrofolate synthase activity
DI291_RS15120	COG0525	valine-tRNA ligase activity
DI291_RS15130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DI291_RS15135	COG1388	LysM domain
DI291_RS15140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DI291_RS15145	COG0113	porphobilinogen synthase activity
DI291_RS15150	COG1587	Uroporphyrinogen-III synthase
DI291_RS15155	COG0181	hydroxymethylbilane synthase activity
DI291_RS15160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DI291_RS15165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DI291_RS15175	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DI291_RS15180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DI291_RS15185	COG1067	ATP-dependent peptidase activity
DI291_RS15185	COG0470	DNA polymerase III
DI291_RS15190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DI291_RS15195	COG0544	peptidyl-prolyl cis-trans isomerase activity
DI291_RS15200	COG0457	Tetratricopeptide repeat
DI291_RS15200	COG1477	protein flavinylation
DI291_RS15205	COG0066	3-isopropylmalate dehydratase activity
DI291_RS15210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DI291_RS15215	COG0473	3-isopropylmalate dehydrogenase activity
DI291_RS15220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DI291_RS15225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DI291_RS15230	COG0440	acetolactate synthase activity
DI291_RS15235	COG0028	Belongs to the TPP enzyme family
DI291_RS15240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DI291_RS15245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DI291_RS15275	COG0622	Phosphoesterase
DI291_RS15280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DI291_RS15285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DI291_RS15290	COG5401	PFAM Sporulation and spore germination
DI291_RS15295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DI291_RS15300	COG1846	Transcriptional regulator
DI291_RS15305	COG2197	response regulator
DI291_RS15310	COG4221	oxidoreductase activity
DI291_RS15315	COG0824	Thioesterase
DI291_RS15320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DI291_RS15325	COG1053	succinate dehydrogenase
DI291_RS15330	COG2009	succinate dehydrogenase
DI291_RS15335	COG1719	4-vinyl reductase, 4VR
DI291_RS15340	COG0527	aspartate kinase activity
DI291_RS15345	COG0322	excinuclease ABC activity
DI291_RS15350	COG3118	belongs to the thioredoxin family
DI291_RS15355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DI291_RS15360	COG2086	electron transfer activity
DI291_RS15365	COG1024	Enoyl-CoA hydratase
DI291_RS15370	COG1309	transcriptional regulator
DI291_RS15375	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_RS15380	COG3766	membrane
DI291_RS15385	COG1193	negative regulation of DNA recombination
DI291_RS15390	COG1796	DNA polymerase
DI291_RS15390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DI291_RS15395	COG1286	toxin biosynthetic process
DI291_RS15400	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DI291_RS15405	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DI291_RS15420	COG0072	phenylalanine-tRNA ligase activity
DI291_RS15420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_RS15425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DI291_RS15430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DI291_RS15440	COG1966	Carbon starvation protein
DI291_RS15445	COG1309	transcriptional regulator
DI291_RS15450	COG3402	PFAM membrane-flanked domain
DI291_RS15465	COG3534	alpha-L-arabinofuranosidase
DI291_RS15470	COG0395	ABC-type sugar transport system, permease component
DI291_RS15475	COG1175	transmembrane transport
DI291_RS15480	COG1653	transport
DI291_RS15485	COG0371	Dehydrogenase
DI291_RS15490	COG0235	Class ii aldolase
DI291_RS15495	COG1069	ribulokinase activity
DI291_RS15500	COG2160	L-arabinose isomerase activity
DI291_RS15505	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_RS15510	COG1363	Peptidase, m42
DI291_RS15520	COG3326	Membrane
DI291_RS15525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DI291_RS15530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DI291_RS15535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DI291_RS15540	COG1346	cytolysis
DI291_RS15550	COG3540	Alkaline phosphatase
DI291_RS15555	COG3279	Response regulator of the LytR AlgR family
DI291_RS15560	COG3275	phosphorelay sensor kinase activity
DI291_RS15570	COG1011	Hydrolase
DI291_RS15575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DI291_RS15585	COG0398	Pfam SNARE associated Golgi protein
DI291_RS15590	COG1484	DNA-dependent DNA replication
DI291_RS15595	COG3611	Membrane attachment protein
DI291_RS15600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DI291_RS15610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DI291_RS15615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DI291_RS15620	COG3866	Pectate lyase
DI291_RS15625	COG0237	dephospho-CoA kinase activity
DI291_RS15630	COG1971	Probably functions as a manganese efflux pump
DI291_RS15635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DI291_RS15640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DI291_RS15640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DI291_RS15645	COG5002	protein histidine kinase activity
DI291_RS15650	COG0745	RESPONSE REGULATOR receiver
DI291_RS15655	COG0039	L-malate dehydrogenase activity
DI291_RS15660	COG0538	isocitrate dehydrogenase activity
DI291_RS15665	COG0372	Belongs to the citrate synthase family
DI291_RS15670	COG2273	Hydrolase Family 16
DI291_RS15680	COG2707	UPF0756 membrane protein
DI291_RS15685	COG0628	permease
DI291_RS15690	COG3030	protein affecting phage T7 exclusion by the F plasmid
DI291_RS15700	COG0205	6-phosphofructokinase activity
DI291_RS15705	COG0825	malonyl-CoA metabolic process
DI291_RS15710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DI291_RS15715	COG0281	malic enzyme
DI291_RS15720	COG0587	DNA-directed DNA polymerase activity
DI291_RS15740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DI291_RS15750	COG4109	DRTGG domain
DI291_RS15755	COG1695	Transcriptional regulator
DI291_RS15760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DI291_RS15765	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS15775	COG0165	Argininosuccinate lyase
DI291_RS15780	COG0137	argininosuccinate synthase activity
DI291_RS15785	COG0521	Mo-molybdopterin cofactor biosynthetic process
DI291_RS15790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DI291_RS15795	COG0827	DNA restriction-modification system
DI291_RS15800	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DI291_RS15805	COG3874	Sporulation protein YtfJ
DI291_RS15815	COG1714	RDD family
DI291_RS15820	COG0616	signal peptide processing
DI291_RS15825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DI291_RS15830	COG1846	Transcriptional regulator
DI291_RS15835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DI291_RS15845	COG0301	tRNA thio-modification
DI291_RS15850	COG1104	cysteine desulfurase activity
DI291_RS15855	COG1114	Component of the transport system for branched-chain amino acids
DI291_RS15860	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DI291_RS15865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DI291_RS15870	COG1309	transcriptional regulator
DI291_RS15875	COG1956	GAF domain-containing protein
DI291_RS15880	COG2203	Gaf domain
DI291_RS15880	COG2199	diguanylate cyclase activity
DI291_RS15885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DI291_RS15895	COG3152	Membrane
DI291_RS15905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DI291_RS15910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DI291_RS15915	COG0454	-acetyltransferase
DI291_RS15920	COG0517	IMP dehydrogenase activity
DI291_RS15925	COG0123	including yeast histone deacetylase and acetoin utilization protein
DI291_RS15930	COG1360	Flagellar Motor Protein
DI291_RS15935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DI291_RS15940	COG1609	Transcriptional regulator
DI291_RS15945	COG1605	Chorismate mutase
DI291_RS15945	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DI291_RS15955	COG3118	belongs to the thioredoxin family
DI291_RS15960	COG4980	gas vesicle protein
DI291_RS15965	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DI291_RS15970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DI291_RS15975	COG1674	ftsk spoiiie
DI291_RS15980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_RS15985	COG4848	Belongs to the UPF0354 family
DI291_RS15990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS16000	COG1363	Peptidase, m42
DI291_RS16005	COG5584	Small secreted protein
DI291_RS16010	COG0281	malic enzyme
DI291_RS16015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_RS16020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DI291_RS16030	COG0510	thiamine kinase activity
DI291_RS16035	COG1523	belongs to the glycosyl hydrolase 13 family
DI291_RS16040	COG1597	lipid kinase activity
DI291_RS16050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DI291_RS16055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DI291_RS16070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DI291_RS16075	COG2252	PERMEase
DI291_RS16080	COG4473	ABC transporter
DI291_RS16085	COG1131	(ABC) transporter
DI291_RS16090	COG1349	DNA-binding transcription factor activity
DI291_RS16095	COG1187	pseudouridine synthase activity
DI291_RS16100	COG2244	polysaccharide biosynthetic process
DI291_RS16105	COG2081	HI0933 family
DI291_RS16110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DI291_RS16120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_RS16125	COG0457	Tetratricopeptide repeat
DI291_RS16135	COG5578	integral membrane protein
DI291_RS16140	COG0673	inositol 2-dehydrogenase activity
DI291_RS16145	COG1653	transport
DI291_RS16150	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DI291_RS16155	COG4209	transmembrane transport
DI291_RS16160	COG2207	Transcriptional regulator
DI291_RS16165	COG1653	transport
DI291_RS16170	COG0395	ABC-type sugar transport system, permease component
DI291_RS16175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI291_RS16180	COG1073	alpha beta
DI291_RS16190	COG0583	DNA-binding transcription factor activity
DI291_RS16195	COG0346	lactoylglutathione lyase activity
DI291_RS16200	COG0495	leucyl-tRNA aminoacylation
DI291_RS16210	COG2814	Major facilitator Superfamily
DI291_RS16215	COG1464	Belongs to the NlpA lipoprotein family
DI291_RS16220	COG2433	Pfam Transposase IS66
DI291_RS16225	COG0577	efflux transmembrane transporter activity
DI291_RS16230	COG1136	(ABC) transporter
DI291_RS16240	COG1131	(ABC) transporter
DI291_RS16245	COG1725	Transcriptional regulator
DI291_RS16255	COG1242	4 iron, 4 sulfur cluster binding
DI291_RS16260	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DI291_RS16265	COG1301	dicarboxylic acid transport
DI291_RS16275	COG2267	carboxylic ester hydrolase activity
DI291_RS16280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DI291_RS16285	COG0671	phosphoesterase, PA-phosphatase related
DI291_RS16290	COG0438	transferase activity, transferring glycosyl groups
DI291_RS16290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI291_RS16295	COG0367	asparagine synthase
DI291_RS16300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DI291_RS16305	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DI291_RS16310	COG1301	dicarboxylic acid transport
DI291_RS16320	COG1506	peptidase
DI291_RS16325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DI291_RS16330	COG1116	anion transmembrane transporter activity
DI291_RS16335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DI291_RS16340	COG0494	nUDIX hydrolase
DI291_RS16350	COG4824	toxin secretion phage lysis holin
DI291_RS16355	COG0783	Belongs to the Dps family
DI291_RS16370	COG1854	S-ribosylhomocysteine lyase activity
DI291_RS16375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DI291_RS16380	COG0288	reversible hydration of carbon dioxide
DI291_RS16385	COG0523	cobalamin synthesis protein
DI291_RS16390	COG0803	Belongs to the bacterial solute-binding protein 9 family
DI291_RS16395	COG0254	rRNA binding
DI291_RS16400	COG1271	oxidase subunit
DI291_RS16405	COG1294	oxidase, subunit
DI291_RS16420	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_RS16425	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_RS16430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DI291_RS16435	COG0596	Alpha beta hydrolase
DI291_RS16440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DI291_RS16445	COG1169	isochorismate synthase
DI291_RS16450	COG1575	Belongs to the MenA family. Type 1 subfamily
DI291_RS16455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DI291_RS16460	COG0058	SHG alpha-glucan phosphorylase activity
DI291_RS16465	COG0297	glycogen (starch) synthase activity
DI291_RS16470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DI291_RS16475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DI291_RS16480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DI291_RS16600	COG1609	Transcriptional regulator
DI291_RS16605	COG3859	Proton-coupled thiamine transporter YuaJ
DI291_RS16610	COG3764	Sortase (surface protein transpeptidase)
DI291_RS16625	COG0457	Tetratricopeptide repeat
DI291_RS16630	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DI291_RS16635	COG0569	domain protein
DI291_RS16640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DI291_RS16650	COG2318	DinB family
DI291_RS16660	COG1454	alcohol dehydrogenase
DI291_RS16665	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS16670	COG1510	regulation of RNA biosynthetic process
DI291_RS16680	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DI291_RS16685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DI291_RS16690	COG2140	Oxalate decarboxylase
DI291_RS16745	COG1397	ADP-ribosylglycohydrolase
DI291_RS16785	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DI291_RS16800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI291_RS16805	COG0726	polysaccharide deacetylase
DI291_RS16810	COG1408	metallophosphoesterase
DI291_RS16815	COG1968	undecaprenyl-diphosphatase activity
DI291_RS16820	COG0628	permease
DI291_RS16825	COG0673	inositol 2-dehydrogenase activity
DI291_RS16830	COG0693	protein deglycase activity
DI291_RS16835	COG0840	transmembrane signaling receptor activity
DI291_RS16840	COG0840	transmembrane signaling receptor activity
DI291_RS16845	COG0840	transmembrane signaling receptor activity
DI291_RS16855	COG2070	2-Nitropropane dioxygenase
DI291_RS16860	COG0432	Pfam Uncharacterised protein family UPF0047
DI291_RS16865	COG0366	Alpha amylase catalytic
DI291_RS16880	COG5297	Belongs to the glycosyl hydrolase family 6
DI291_RS16885	COG1253	flavin adenine dinucleotide binding
DI291_RS16890	COG2738	Putative neutral zinc metallopeptidase
DI291_RS16905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DI291_RS16915	COG2323	membrane
DI291_RS16920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DI291_RS16935	COG0166	Belongs to the GPI family
DI291_RS16940	COG1979	alcohol dehydrogenase
DI291_RS16945	COG2155	Conserved Protein
DI291_RS16950	COG1098	S1 RNA binding domain
DI291_RS16955	COG0436	Aminotransferase
DI291_RS16960	COG1522	sequence-specific DNA binding
DI291_RS16965	COG2267	carboxylic ester hydrolase activity
DI291_RS16980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DI291_RS16995	COG5018	Exonuclease
DI291_RS17000	COG2814	Major facilitator Superfamily
DI291_RS17005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DI291_RS17010	COG3011	Protein conserved in bacteria
DI291_RS17020	COG3290	protein histidine kinase activity
DI291_RS17025	COG4565	transcriptional regulatory protein
DI291_RS17030	COG1183	phosphatidylcholine synthase activity
DI291_RS17035	COG0586	Pfam SNARE associated Golgi protein
DI291_RS17040	COG0688	phosphatidylethanolamine metabolic process
DI291_RS17045	COG3493	citrate carrier protein
DI291_RS17055	COG2111	Na H antiporter
DI291_RS17055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DI291_RS17060	COG2111	Na H antiporter
DI291_RS17065	COG1006	Multisubunit Na H antiporter MnhC subunit
DI291_RS17070	COG0651	ATP synthesis coupled electron transport
DI291_RS17075	COG1863	multisubunit Na H antiporter MnhE subunit
DI291_RS17080	COG2212	antiporter activity
DI291_RS17085	COG1320	monovalent cation:proton antiporter activity
DI291_RS17090	COG2050	protein possibly involved in aromatic compounds catabolism
DI291_RS17095	COG2197	response regulator
DI291_RS17100	COG4585	Histidine kinase
DI291_RS17110	COG0142	geranyltranstransferase activity
DI291_RS17125	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DI291_RS17130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DI291_RS17135	COG1335	isochorismatase
DI291_RS17140	COG5506	Protein of unknown function (DUF1694)
DI291_RS17155	COG0628	permease
DI291_RS17160	COG1959	2 iron, 2 sulfur cluster binding
DI291_RS17165	COG0657	acetylesterase activity
DI291_RS17175	COG1418	mRNA catabolic process
DI291_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS17195	COG1511	domain protein
DI291_RS17200	COG1674	ftsk spoiiie
DI291_RS17200	COG0433	COG0433 Predicted ATPase
DI291_RS17205	COG4499	WXG100 protein secretion system (Wss), protein YukC
DI291_RS17210	COG5417	Belongs to the EsaB family
DI291_RS17215	COG4842	Belongs to the WXG100 family
DI291_RS17220	COG1115	amino acid carrier protein
DI291_RS17225	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DI291_RS17225	COG2508	Transcriptional regulator
DI291_RS17230	COG0686	Belongs to the AlaDH PNT family
DI291_RS17240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DI291_RS17245	COG1268	BioY protein
DI291_RS17250	COG2056	Na+-H+ antiporter family
DI291_RS17255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DI291_RS17260	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DI291_RS17265	COG3584	3D domain protein
DI291_RS17280	COG1252	NADH dehydrogenase
DI291_RS17285	COG0492	ferredoxin-NADP+ reductase activity
DI291_RS17300	COG0456	acetyltransferase
DI291_RS17305	COG0316	Belongs to the HesB IscA family
DI291_RS17310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DI291_RS17315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DI291_RS17320	COG4844	belongs to the
DI291_RS17325	COG1252	NADH dehydrogenase
DI291_RS17330	COG5646	InterPro IPR014922
DI291_RS17345	COG0457	Tetratricopeptide repeat
DI291_RS17350	COG3479	Phenolic acid decarboxylase
DI291_RS17360	COG4837	Protein of unknown function (DUF1462)
DI291_RS17365	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DI291_RS17370	COG4946	Tricorn protease homolog
DI291_RS17370	COG1506	peptidase
DI291_RS17370	COG0823	Involved in the tonB-independent uptake of proteins
DI291_RS17375	COG0083	homoserine kinase activity
DI291_RS17380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DI291_RS17385	COG0460	homoserine dehydrogenase
DI291_RS17390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DI291_RS17395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DI291_RS17400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DI291_RS17405	COG0647	UMP catabolic process
DI291_RS17410	COG2445	Protein of unknown function DUF86
DI291_RS17415	COG4470	Protein conserved in bacteria
DI291_RS17430	COG0739	heme binding
DI291_RS17440	COG0733	neurotransmitter:sodium symporter activity
DI291_RS17450	COG3377	Domain of unknown function (DUF1805)
DI291_RS17455	COG0737	Belongs to the 5'-nucleotidase family
DI291_RS17460	COG0730	response to heat
DI291_RS17465	COG1801	Protein of unknown function DUF72
DI291_RS17475	COG3226	Transcriptional regulator
DI291_RS17485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DI291_RS17490	COG2508	Transcriptional regulator
DI291_RS17495	COG2814	Major facilitator Superfamily
DI291_RS17500	COG1288	antiporter activity
DI291_RS17505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DI291_RS17515	COG2356	endonuclease I
DI291_RS17525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DI291_RS17540	COG0457	Tetratricopeptide repeat
DI291_RS17550	COG0719	Fe-S assembly protein
DI291_RS17555	COG0822	iron-sulfur transferase activity
DI291_RS17560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DI291_RS17565	COG0719	Fe-S assembly protein
DI291_RS17570	COG0396	ATPase activity
DI291_RS17580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DI291_RS17585	COG1464	Belongs to the NlpA lipoprotein family
DI291_RS17590	COG2011	ABC-type metal ion transport system permease component
DI291_RS17595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DI291_RS17605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_RS17610	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DI291_RS17620	COG0509	glycine decarboxylation via glycine cleavage system
DI291_RS17625	COG1393	Belongs to the ArsC family
DI291_RS17630	COG1960	acyl-CoA dehydrogenase activity
DI291_RS17635	COG0183	Belongs to the thiolase family
DI291_RS17640	COG1250	3-hydroxyacyl-CoA dehydrogenase
DI291_RS17640	COG1024	Enoyl-CoA hydratase
DI291_RS17655	COG5577	PFAM Coat F domain
DI291_RS17670	COG1120	ATPase activity
DI291_RS17675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS17680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS17685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_RS17700	COG1686	Belongs to the peptidase S11 family
DI291_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS17710	COG0783	Belongs to the Dps family
DI291_RS17715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DI291_RS17720	COG0745	RESPONSE REGULATOR receiver
DI291_RS17725	COG2205	protein histidine kinase activity
DI291_RS17725	COG2770	Histidine kinase
DI291_RS17735	COG1309	transcriptional regulator
DI291_RS17740	COG0114	fumarate hydratase activity
DI291_RS17750	COG0697	spore germination
DI291_RS17755	COG0814	amino acid
DI291_RS17770	COG2197	response regulator
DI291_RS17775	COG4585	Histidine kinase
DI291_RS17780	COG4758	membrane
DI291_RS17790	COG1842	Phage shock protein A
DI291_RS17795	COG4758	membrane
DI291_RS17800	COG4677	pectinesterase activity
DI291_RS17805	COG2096	Adenosyltransferase
DI291_RS17810	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS17830	COG1454	alcohol dehydrogenase
DI291_RS17835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DI291_RS17840	COG1120	ATPase activity
DI291_RS17845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS17850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_RS17855	COG1802	Transcriptional regulator
DI291_RS17860	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS17865	COG2258	MOSC domain
DI291_RS17870	COG0583	DNA-binding transcription factor activity
DI291_RS17880	COG2721	sulfolactate sulfo-lyase activity
DI291_RS17885	COG0246	Mannitol dehydrogenase
DI291_RS17890	COG1609	Transcriptional regulator
DI291_RS17895	COG2211	Major facilitator Superfamily
DI291_RS17900	COG1904	glucuronate isomerase
DI291_RS17905	COG2205	protein histidine kinase activity
DI291_RS17910	COG0745	RESPONSE REGULATOR receiver
DI291_RS17915	COG1120	ATPase activity
DI291_RS17920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS17925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS17930	COG0531	amino acid
DI291_RS17940	COG1988	membrane-bound metal-dependent
DI291_RS17945	COG1368	sulfuric ester hydrolase activity
DI291_RS17950	COG2814	Major facilitator Superfamily
DI291_RS17955	COG0656	L-ascorbic acid biosynthetic process
DI291_RS17960	COG1940	carbohydrate kinase activity
DI291_RS17965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DI291_RS17975	COG0596	Alpha beta hydrolase
DI291_RS17980	COG3973	AAA domain
DI291_RS17985	COG2860	membrane
DI291_RS17990	COG0456	acetyltransferase
DI291_RS17990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DI291_RS17995	COG0456	acetyltransferase
DI291_RS18000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DI291_RS18005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DI291_RS18010	COG2217	Heavy metal translocating P-type atpase
DI291_RS18015	COG1653	transport
DI291_RS18020	COG1175	transmembrane transport
DI291_RS18025	COG0395	ABC-type sugar transport system, permease component
DI291_RS18030	COG1501	Belongs to the glycosyl hydrolase 31 family
DI291_RS18035	COG1472	Belongs to the glycosyl hydrolase 3 family
DI291_RS18040	COG1121	(ABC) transporter
DI291_RS18045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DI291_RS18050	COG0803	Belongs to the bacterial solute-binding protein 9 family
DI291_RS18070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS18070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_RS18070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_RS18075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS18090	COG2217	Heavy metal translocating P-type atpase
DI291_RS18095	COG2608	mercury ion transmembrane transporter activity
DI291_RS18100	COG1937	Protein conserved in bacteria
DI291_RS18105	COG0693	protein deglycase activity
DI291_RS18110	COG1349	DNA-binding transcription factor activity
DI291_RS18115	COG1070	Carbohydrate kinase
DI291_RS18120	COG4952	isomerase
DI291_RS18130	COG3347	Dehydrogenase
DI291_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS18140	COG2814	Major facilitator Superfamily
DI291_RS18145	COG2814	Major facilitator Superfamily
DI291_RS18155	COG2124	cytochrome p450
DI291_RS18165	COG1846	Transcriptional regulator
DI291_RS18175	COG0673	inositol 2-dehydrogenase activity
DI291_RS18180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DI291_RS18185	COG1054	Belongs to the UPF0176 family
DI291_RS18195	COG1191	sigma factor activity
DI291_RS18205	COG2140	Oxalate decarboxylase
DI291_RS18225	COG5520	Belongs to the glycosyl hydrolase 30 family
DI291_RS18230	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_RS18250	COG5444	nuclease activity
DI291_RS18270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DI291_RS18275	COG0557	exoribonuclease II activity
DI291_RS18280	COG1647	Serine aminopeptidase, S33
DI291_RS18285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DI291_RS18290	COG2002	toxin-antitoxin pair type II binding
DI291_RS18295	COG1476	TRANSCRIPTIONal
DI291_RS18300	COG1396	sequence-specific DNA binding
DI291_RS18305	COG1396	sequence-specific DNA binding
DI291_RS18310	COG1174	glycine betaine transport
DI291_RS18315	COG1732	Glycine betaine
DI291_RS18320	COG1174	glycine betaine transport
DI291_RS18325	COG1125	glycine betaine transport
DI291_RS18325	COG0517	IMP dehydrogenase activity
DI291_RS18330	COG1510	regulation of RNA biosynthetic process
DI291_RS18335	COG2095	MarC family integral membrane protein
DI291_RS18340	COG3064	Membrane
DI291_RS18345	COG4640	response to antibiotic
DI291_RS18350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_RS18360	COG0693	protein deglycase activity
DI291_RS18365	COG0148	phosphopyruvate hydratase activity
DI291_RS18370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DI291_RS18375	COG0149	triose-phosphate isomerase activity
DI291_RS18380	COG0126	phosphoglycerate kinase activity
DI291_RS18385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DI291_RS18390	COG2390	Transcriptional regulator
DI291_RS18395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DI291_RS18400	COG1113	amino acid transport
DI291_RS18420	COG1556	Lactate utilization protein
DI291_RS18425	COG1139	Iron-sulfur cluster binding protein
DI291_RS18430	COG0247	lactate metabolic process
DI291_RS18435	COG2186	Transcriptional regulator
DI291_RS18440	COG1620	l-lactate permease
DI291_RS18445	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DI291_RS18455	COG5039	Polysaccharide pyruvyl transferase
DI291_RS18460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DI291_RS18465	COG0110	maltose O-acetyltransferase activity
DI291_RS18470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DI291_RS18475	COG2244	polysaccharide biosynthetic process
DI291_RS18480	COG1216	Glycosyl transferase, family 2
DI291_RS18485	COG5039	Polysaccharide pyruvyl transferase
DI291_RS18490	COG1216	Glycosyl transferase, family 2
DI291_RS18500	COG0438	transferase activity, transferring glycosyl groups
DI291_RS18505	COG1215	transferase activity, transferring glycosyl groups
DI291_RS18510	COG0438	transferase activity, transferring glycosyl groups
DI291_RS18515	COG1086	Polysaccharide biosynthesis protein
DI291_RS18520	COG0489	protein tyrosine kinase activity
DI291_RS18525	COG3944	biosynthesis protein
DI291_RS18530	COG1396	sequence-specific DNA binding
DI291_RS18535	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_RS18540	COG2271	Major facilitator Superfamily
DI291_RS18550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DI291_RS18560	COG1454	alcohol dehydrogenase
DI291_RS18565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DI291_RS18575	COG1733	regulation of RNA biosynthetic process
DI291_RS18580	COG1902	pentaerythritol trinitrate reductase activity
DI291_RS18585	COG1621	beta-fructofuranosidase activity
DI291_RS18590	COG1621	beta-fructofuranosidase activity
DI291_RS18610	COG0740	serine-type endopeptidase activity
DI291_RS18615	COG1611	Belongs to the LOG family
DI291_RS18620	COG1694	Mazg nucleotide pyrophosphohydrolase
DI291_RS18625	COG1078	dGTPase activity
DI291_RS18630	COG0659	secondary active sulfate transmembrane transporter activity
DI291_RS18635	COG0288	reversible hydration of carbon dioxide
DI291_RS18640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DI291_RS18645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DI291_RS18650	COG0640	Transcriptional regulator
DI291_RS18660	COG2732	(Barnase) inhibitor
DI291_RS18665	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DI291_RS18670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS18675	COG1481	regulation of sporulation
DI291_RS18680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DI291_RS18685	COG1660	Displays ATPase and GTPase activities
DI291_RS18690	COG1051	belongs to the nudix hydrolase family
DI291_RS18695	COG0492	ferredoxin-NADP+ reductase activity
DI291_RS18700	COG0457	Tetratricopeptide repeat
DI291_RS18705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_RS18710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DI291_RS18710	COG0140	phosphoribosyl-ATP diphosphatase activity
DI291_RS18715	COG0107	imidazoleglycerol-phosphate synthase activity
DI291_RS18720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DI291_RS18725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DI291_RS18730	COG0131	Imidazoleglycerol-phosphate dehydratase
DI291_RS18735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DI291_RS18740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DI291_RS18745	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DI291_RS18750	COG4990	cell redox homeostasis
DI291_RS18755	COG5297	Belongs to the glycosyl hydrolase family 6
DI291_RS18760	COG0110	maltose O-acetyltransferase activity
DI291_RS18765	COG0546	phosphoglycolate phosphatase activity
DI291_RS18770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DI291_RS18775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DI291_RS18780	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DI291_RS18785	COG1846	Transcriptional regulator
DI291_RS18790	COG2814	Major facilitator Superfamily
DI291_RS18795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DI291_RS18800	COG1950	PFAM Membrane protein of
DI291_RS18805	COG1983	PspC domain protein
DI291_RS18810	COG3595	metallopeptidase activity
DI291_RS18830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DI291_RS18835	COG0556	nucleotide-excision repair
DI291_RS18840	COG4897	Protein conserved in bacteria
DI291_RS18850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DI291_RS18860	COG0793	Belongs to the peptidase S41A family
DI291_RS18860	COG3409	Peptidoglycan-binding domain 1 protein
DI291_RS18865	COG0473	3-isopropylmalate dehydrogenase activity
DI291_RS18870	COG3883	PFAM NLP P60 protein
DI291_RS18870	COG0791	NLP P60 protein
DI291_RS18875	COG2177	Part of the ABC transporter FtsEX involved in
DI291_RS18880	COG2884	Cell division ATP-binding protein ftsE
DI291_RS18885	COG2010	Cytochrome c
DI291_RS18890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_RS18900	COG0653	protein targeting
DI291_RS18905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DI291_RS18920	COG1516	flagellar protein fliS
DI291_RS18925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DI291_RS18930	COG1334	flagellar protein FlaG
DI291_RS18935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DI291_RS18940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DI291_RS18945	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DI291_RS18955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DI291_RS18960	COG4786	Flagellar basal body rod
DI291_RS18960	COG1256	bacterial-type flagellum assembly
DI291_RS18965	COG3418	PFAM FlgN family protein
DI291_RS18970	COG2747	anti-sigma28 factor FlgM
DI291_RS18980	COG1040	competence protein
DI291_RS18990	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DI291_RS18995	COG1307	EDD domain protein, DegV family
DI291_RS19000	COG2197	response regulator
DI291_RS19005	COG4585	Histidine kinase
DI291_RS19010	COG1739	Uncharacterized protein family UPF0029
DI291_RS19015	COG1316	TRANSCRIPTIONal
DI291_RS19025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DI291_RS19030	COG0438	transferase activity, transferring glycosyl groups
DI291_RS19035	COG1215	transferase activity, transferring glycosyl groups
DI291_RS19040	COG3206	protein involved in exopolysaccharide biosynthesis
DI291_RS19045	COG3307	-O-antigen
DI291_RS19050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI291_RS19055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DI291_RS19060	COG0297	glycogen (starch) synthase activity
DI291_RS19060	COG0438	transferase activity, transferring glycosyl groups
DI291_RS19065	COG2244	polysaccharide biosynthetic process
DI291_RS19075	COG2247	cell wall binding repeat
DI291_RS19075	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_RS19085	COG1316	TRANSCRIPTIONal
DI291_RS19090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DI291_RS19095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DI291_RS19100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DI291_RS19105	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DI291_RS19110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DI291_RS19115	COG0438	transferase activity, transferring glycosyl groups
DI291_RS19120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DI291_RS19130	COG1682	transport, permease protein
DI291_RS19135	COG1134	teichoic acid transport
DI291_RS19140	COG4193	domain, Protein
DI291_RS19160	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DI291_RS19165	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DI291_RS19170	COG0438	transferase activity, transferring glycosyl groups
DI291_RS19180	COG4193	domain, Protein
DI291_RS19185	COG1482	cell wall glycoprotein biosynthetic process
DI291_RS19205	COG0800	Aldolase
DI291_RS19210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DI291_RS19215	COG1609	Transcriptional regulator
DI291_RS19220	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DI291_RS19225	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS19230	COG1063	alcohol dehydrogenase
DI291_RS19240	COG2814	Major facilitator Superfamily
DI291_RS19245	COG1316	TRANSCRIPTIONal
DI291_RS19250	COG0561	phosphatase activity
DI291_RS19255	COG0791	NLP P60 protein
DI291_RS19265	COG2843	Capsule synthesis protein
DI291_RS19275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DI291_RS19280	COG1609	Transcriptional regulator
DI291_RS19285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DI291_RS19290	COG1869	D-ribose catabolic process
DI291_RS19295	COG1129	ABC transporter
DI291_RS19300	COG1172	Belongs to the binding-protein-dependent transport system permease family
DI291_RS19305	COG1879	ABC-type sugar transport system periplasmic component
DI291_RS19310	COG0583	DNA-binding transcription factor activity
DI291_RS19315	COG2226	methyltransferase
DI291_RS19320	COG3527	Alpha-acetolactate decarboxylase
DI291_RS19325	COG0028	Belongs to the TPP enzyme family
DI291_RS19330	COG0583	DNA-binding transcription factor activity
DI291_RS19335	COG0405	Gamma-glutamyltransferase
DI291_RS19340	COG1522	sequence-specific DNA binding
DI291_RS19345	COG2059	Chromate
DI291_RS19350	COG2059	Chromate
DI291_RS19355	COG4464	protein tyrosine phosphatase activity
DI291_RS19360	COG3944	biosynthesis protein
DI291_RS19370	COG4715	Zinc finger, swim domain protein
DI291_RS19375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DI291_RS19380	COG3878	Protein conserved in bacteria
DI291_RS19385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DI291_RS19400	COG0561	phosphatase activity
DI291_RS19405	COG1349	DNA-binding transcription factor activity
DI291_RS19415	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS19425	COG3732	PTS system glucitol sorbitol-specific
DI291_RS19445	COG0629	single-stranded DNA binding
DI291_RS19460	COG1970	mechanosensitive ion channel activity
DI291_RS19465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DI291_RS19470	COG4786	Flagellar basal body rod
DI291_RS19475	COG4786	Flagellar basal body rod
DI291_RS19480	COG1077	Cell shape determining protein MreB Mrl
DI291_RS19485	COG1609	Transcriptional regulator
DI291_RS19490	COG1846	Transcriptional regulator
DI291_RS19495	COG2814	Major facilitator Superfamily
DI291_RS19500	COG0671	phosphoesterase, PA-phosphatase related
DI291_RS19505	COG1227	inorganic diphosphatase activity
DI291_RS19510	COG3546	catalase activity
DI291_RS19515	COG3361	conserved protein (COG2071)
DI291_RS19530	COG0517	IMP dehydrogenase activity
DI291_RS19535	COG0598	Magnesium transport protein CorA
DI291_RS19540	COG1253	flavin adenine dinucleotide binding
DI291_RS19545	COG0004	ammonium transporteR
DI291_RS19550	COG0347	Belongs to the P(II) protein family
DI291_RS19555	COG0740	serine-type endopeptidase activity
DI291_RS19565	COG0739	heme binding
DI291_RS19570	COG1247	-acetyltransferase
DI291_RS19580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DI291_RS19585	COG0477	Major facilitator Superfamily
DI291_RS19590	COG3251	PFAM MbtH domain protein
DI291_RS19595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS19600	COG1535	isochorismatase
DI291_RS19600	COG3433	isochorismatase activity
DI291_RS19605	COG1021	2,3-dihydroxybenzoate-AMP ligase
DI291_RS19610	COG1169	isochorismate synthase
DI291_RS19615	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_RS19620	COG2819	hydrolase of the alpha beta superfamily
DI291_RS19625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS19630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS19635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_RS19640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_RS19640	COG2207	Transcriptional regulator
DI291_RS19650	COG2910	NAD(P)H-binding
DI291_RS19655	COG1959	2 iron, 2 sulfur cluster binding
DI291_RS19665	COG1994	Peptidase M50
DI291_RS19670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DI291_RS19675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DI291_RS19680	COG2223	nitrite transmembrane transporter activity
DI291_RS19685	COG3383	formate dehydrogenase (NAD+) activity
DI291_RS19690	COG2304	oxidoreductase activity
DI291_RS19695	COG2304	oxidoreductase activity
DI291_RS19700	COG2385	sporulation resulting in formation of a cellular spore
DI291_RS19705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DI291_RS19715	COG4836	Membrane
DI291_RS19720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DI291_RS19725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DI291_RS19730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DI291_RS19735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DI291_RS19740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DI291_RS19745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DI291_RS19755	COG0356	it plays a direct role in the translocation of protons across the membrane
DI291_RS19765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DI291_RS19770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DI291_RS19775	COG4475	Protein of unknown function (DUF436)
DI291_RS19780	COG0698	ribose 5-phosphate isomerase
DI291_RS19785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DI291_RS19790	COG1971	Probably functions as a manganese efflux pump
DI291_RS19795	COG0009	L-threonylcarbamoyladenylate synthase
DI291_RS19800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DI291_RS19810	COG0738	Major facilitator superfamily
DI291_RS19815	COG0673	inositol 2-dehydrogenase activity
DI291_RS19820	COG0561	phosphatase activity
DI291_RS19825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DI291_RS19830	COG1609	Transcriptional regulator
DI291_RS19835	COG2890	protein-(glutamine-N5) methyltransferase activity
DI291_RS19840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DI291_RS19845	COG0346	lactoylglutathione lyase activity
DI291_RS19850	COG0789	Transcriptional regulator
DI291_RS19855	COG0679	Auxin Efflux Carrier
DI291_RS19860	COG0281	malic enzyme
DI291_RS19865	COG1435	thymidine kinase activity
DI291_RS19870	COG0254	rRNA binding
DI291_RS19875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DI291_RS19880	COG1494	fructose-1,6-bisphosphatase
DI291_RS19885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DI291_RS19890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DI291_RS19895	COG0191	fructose-bisphosphate aldolase activity
DI291_RS19900	COG2204	response regulator
DI291_RS19905	COG4821	SIS domain
DI291_RS19910	COG0504	CTP synthase activity
DI291_RS19915	COG3343	RNA polymerase activity
DI291_RS19920	COG1960	acyl-CoA dehydrogenase activity
DI291_RS19925	COG1960	acyl-CoA dehydrogenase activity
DI291_RS19930	COG1250	3-hydroxyacyl-CoA dehydrogenase
DI291_RS19935	COG0183	Belongs to the thiolase family
DI291_RS19940	COG0247	lactate metabolic process
DI291_RS19940	COG2181	nitrate reductase activity
DI291_RS19945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DI291_RS19955	COG0018	arginyl-trna synthetase
DI291_RS19960	COG4506	Protein conserved in bacteria
DI291_RS19965	COG0010	Belongs to the arginase family
DI291_RS19970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DI291_RS19975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DI291_RS19985	COG1994	Peptidase M50
DI291_RS19990	COG1942	4-Oxalocrotonate Tautomerase
DI291_RS20000	COG3465	dGTPase activity
DI291_RS20005	COG1078	dGTPase activity
DI291_RS20010	COG4844	belongs to the
DI291_RS20035	COG2814	Major facilitator Superfamily
DI291_RS20060	COG1414	Transcriptional regulator
DI291_RS20070	COG0280	phosphate acetyltransferase
DI291_RS20075	COG3253	May function as heme-dependent peroxidase
DI291_RS20085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DI291_RS20105	COG1131	(ABC) transporter
DI291_RS20120	COG2363	Small membrane protein
DI291_RS20125	COG2233	PERMEase
DI291_RS20135	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS20140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DI291_RS20145	COG1216	Glycosyl transferase, family 2
DI291_RS20150	COG0351	phosphomethylpyrimidine kinase
DI291_RS20160	COG1621	beta-fructofuranosidase activity
DI291_RS20165	COG1263	PTS System
DI291_RS20165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS20170	COG3711	transcriptional antiterminator
DI291_RS20180	COG1404	Belongs to the peptidase S8 family
DI291_RS20190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DI291_RS20200	COG0778	Nitroreductase
DI291_RS20205	COG1473	amidohydrolase
DI291_RS20210	COG0772	Belongs to the SEDS family
DI291_RS20215	COG0772	Belongs to the SEDS family
DI291_RS20220	COG3314	Sporulation integral membrane protein YlbJ
DI291_RS20240	COG0456	acetyltransferase
DI291_RS20275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DI291_RS20285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DI291_RS20290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DI291_RS20295	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DI291_RS20305	COG0655	NAD(P)H dehydrogenase (quinone) activity
DI291_RS20310	COG3162	membrane
DI291_RS20315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_RS20320	COG1070	Carbohydrate kinase
DI291_RS20325	COG2115	Belongs to the xylose isomerase family
DI291_RS20330	COG1940	carbohydrate kinase activity
DI291_RS20335	COG0352	thiamine-phosphate diphosphorylase activity
DI291_RS20340	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DI291_RS20345	COG0583	DNA-binding transcription factor activity
DI291_RS20360	COG1380	Effector of murein hydrolase LrgA
DI291_RS20365	COG1346	cytolysis
DI291_RS20375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_RS20380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DI291_RS20385	COG0346	lactoylglutathione lyase activity
DI291_RS20390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DI291_RS20395	COG1442	glycosyl transferase family 8
DI291_RS20405	COG4585	Histidine kinase
DI291_RS20410	COG2197	response regulator
DI291_RS20415	COG2409	Drug exporters of the RND superfamily
DI291_RS20420	COG5522	Integral membrane protein (intg_mem_TP0381)
DI291_RS20425	COG2271	Major facilitator Superfamily
DI291_RS20430	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_RS20435	COG0800	Aldolase
DI291_RS20440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DI291_RS20450	COG2234	aminopeptidase activity
DI291_RS20455	COG0477	Major facilitator Superfamily
DI291_RS20470	COG2357	RelA SpoT domain protein
DI291_RS20485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_RS20490	COG1696	Membrane protein involved in D-alanine export
DI291_RS20495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DI291_RS20500	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DI291_RS20505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DI291_RS20510	COG2814	Major facilitator Superfamily
DI291_RS20515	COG1486	melibiose metabolic process
DI291_RS20520	COG1447	Phosphotransferase system cellobiose-specific component IIA
DI291_RS20525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_RS20530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_RS20535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_RS20535	COG3711	transcriptional antiterminator
DI291_RS20540	COG2094	Belongs to the DNA glycosylase MPG family
DI291_RS20550	COG0372	Belongs to the citrate synthase family
DI291_RS20555	COG2079	MmgE PrpD family protein
DI291_RS20560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DI291_RS20575	COG1132	(ABC) transporter
DI291_RS20580	COG2755	lipolytic protein G-D-S-L family
DI291_RS20595	COG2814	Major facilitator Superfamily
DI291_RS20600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DI291_RS20605	COG1131	(ABC) transporter
DI291_RS20625	COG1595	DNA-templated transcription, initiation
DI291_RS20630	COG2814	Major facilitator Superfamily
DI291_RS20640	COG0753	catalase activity
DI291_RS20645	COG0753	catalase activity
DI291_RS20650	COG0735	belongs to the Fur family
DI291_RS20655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DI291_RS20665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DI291_RS20670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DI291_RS20675	COG4988	ABC transporter
DI291_RS20680	COG1294	oxidase, subunit
DI291_RS20685	COG1271	oxidase subunit
DI291_RS20690	COG2116	formate transmembrane transporter activity
DI291_RS20700	COG0281	malic enzyme
DI291_RS20705	COG1757	Na H antiporter
DI291_RS20710	COG1027	Aspartate ammonia-lyase
DI291_RS20715	COG0252	asparaginase activity
DI291_RS20720	COG1396	sequence-specific DNA binding
DI291_RS20725	COG2706	6-phosphogluconolactonase activity
DI291_RS20730	COG0745	RESPONSE REGULATOR receiver
DI291_RS20735	COG2205	protein histidine kinase activity
DI291_RS20740	COG1136	(ABC) transporter
DI291_RS20745	COG0577	efflux transmembrane transporter activity
DI291_RS20750	COG5294	Protein conserved in bacteria
DI291_RS20765	COG0726	polysaccharide deacetylase
DI291_RS20770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_RS20780	COG1215	transferase activity, transferring glycosyl groups
DI291_RS20785	COG3493	citrate carrier protein
DI291_RS20790	COG0584	glycerophosphoryl diester phosphodiesterase
DI291_RS20805	COG1368	sulfuric ester hydrolase activity
DI291_RS20815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_RS20825	COG2235	arginine
DI291_RS20830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DI291_RS20840	COG0549	Belongs to the carbamate kinase family
DI291_RS20850	COG2723	6-phospho-beta-galactosidase activity
DI291_RS20855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_RS20865	COG1595	DNA-templated transcription, initiation
DI291_RS20875	COG2195	Cleaves the N-terminal amino acid of tripeptides
DI291_RS20885	COG2223	nitrite transmembrane transporter activity
DI291_RS20890	COG0395	ABC-type sugar transport system, permease component
DI291_RS20895	COG1175	transmembrane transport
DI291_RS20905	COG1609	Transcriptional regulator
DI291_RS20920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DI291_RS20925	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DI291_RS20930	COG0463	Glycosyl transferase, family 2
DI291_RS20935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DI291_RS20960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DI291_RS20965	COG0693	protein deglycase activity
DI291_RS20965	COG0753	catalase activity
DI291_RS20975	COG2723	6-phospho-beta-galactosidase activity
DI291_RS20980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS20980	COG2190	(PTS) system
DI291_RS20980	COG1263	PTS System
DI291_RS20985	COG3711	transcriptional antiterminator
DI291_RS20990	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DI291_RS20995	COG1122	ATPase activity
DI291_RS21000	COG4721	ABC-type cobalt transport system, permease component
DI291_RS21005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DI291_RS21015	COG2224	Isocitrate lyase
DI291_RS21020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DI291_RS21030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DI291_RS21035	COG0577	efflux transmembrane transporter activity
DI291_RS21040	COG1136	(ABC) transporter
DI291_RS21045	COG2205	protein histidine kinase activity
DI291_RS21050	COG0745	RESPONSE REGULATOR receiver
DI291_RS21055	COG2723	6-phospho-beta-galactosidase activity
DI291_RS21060	COG2190	(PTS) system
DI291_RS21060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_RS21060	COG1263	PTS System
DI291_RS21070	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DI291_RS21080	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_RS21085	COG0513	Belongs to the DEAD box helicase family
DI291_RS21105	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DI291_RS21110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DI291_RS21115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DI291_RS21120	COG2390	Transcriptional regulator
DI291_RS21125	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DI291_RS21130	COG3706	GGDEF domain
DI291_RS21135	COG5298	Protein conserved in bacteria
DI291_RS21140	COG1215	transferase activity, transferring glycosyl groups
DI291_RS21150	COG3977	Valine--pyruvate aminotransferase
DI291_RS21165	COG1181	Belongs to the D-alanine--D-alanine ligase family
DI291_RS21175	COG0191	fructose-bisphosphate aldolase activity
DI291_RS21180	COG1082	Xylose isomerase domain protein TIM barrel
DI291_RS21185	COG1082	Xylose isomerase domain protein TIM barrel
DI291_RS21190	COG0673	inositol 2-dehydrogenase activity
DI291_RS21195	COG2814	Major facilitator Superfamily
DI291_RS21200	COG1082	Xylose isomerase domain protein TIM barrel
DI291_RS21205	COG3962	Belongs to the TPP enzyme family
DI291_RS21210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DI291_RS21215	COG3718	enzyme involved in inositol metabolism
DI291_RS21220	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS21225	COG1349	DNA-binding transcription factor activity
DI291_RS21230	COG0667	Aldo Keto reductase
DI291_RS21235	COG0584	glycerophosphoryl diester phosphodiesterase
DI291_RS21240	COG2271	Major facilitator Superfamily
DI291_RS21245	COG0326	Molecular chaperone. Has ATPase activity
DI291_RS21250	COG0488	(ABC) transporter
DI291_RS21255	COG0561	phosphatase activity
DI291_RS21275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_RS21305	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DI291_RS21310	COG0577	efflux transmembrane transporter activity
DI291_RS21315	COG1136	(ABC) transporter
DI291_RS21320	COG2205	protein histidine kinase activity
DI291_RS21325	COG0745	RESPONSE REGULATOR receiver
DI291_RS21335	COG5278	phosphoserine phosphatase activity
DI291_RS21335	COG0840	transmembrane signaling receptor activity
DI291_RS21340	COG1115	amino acid carrier protein
DI291_RS21345	COG0686	Belongs to the AlaDH PNT family
DI291_RS21350	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DI291_RS21355	COG1874	Beta-galactosidase
DI291_RS21360	COG3833	ABC-type maltose transport systems, permease component
DI291_RS21365	COG1175	transmembrane transport
DI291_RS21370	COG2182	Extracellular solute-binding protein
DI291_RS21375	COG1609	Transcriptional regulator
DI291_RS21385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DI291_RS21390	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DI291_RS21395	COG1940	carbohydrate kinase activity
DI291_RS21405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_RS21435	COG1012	belongs to the aldehyde dehydrogenase family
DI291_RS21435	COG1454	alcohol dehydrogenase
DI291_RS21440	COG0450	alkyl hydroperoxide reductase
DI291_RS21445	COG3634	alkyl hydroperoxide reductase activity
DI291_RS21450	COG1113	amino acid transport
DI291_RS21455	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DI291_RS21465	COG1120	ATPase activity
DI291_RS21470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_RS21475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS21480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_RS21490	COG1131	(ABC) transporter
DI291_RS21495	COG0842	Transport permease protein
DI291_RS21500	COG4585	Histidine kinase
DI291_RS21505	COG2197	response regulator
DI291_RS21520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DI291_RS21535	COG0456	acetyltransferase
DI291_RS21550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DI291_RS21555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DI291_RS21560	COG4853	Protein conserved in bacteria
DI291_RS21565	COG4863	YycH protein
DI291_RS21570	COG5002	protein histidine kinase activity
DI291_RS21575	COG0745	RESPONSE REGULATOR receiver
DI291_RS21600	COG1051	belongs to the nudix hydrolase family
DI291_RS21605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DI291_RS21615	COG0305	Participates in initiation and elongation during chromosome replication
DI291_RS21630	COG3093	addiction module antidote protein HigA
DI291_RS21635	COG2807	transmembrane transport
DI291_RS21640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DI291_RS21645	COG0363	glucosamine-6-phosphate deaminase activity