locus-tag	class	description
HW35_RS00010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW35_RS00015	COG0598	Magnesium transport protein CorA
HW35_RS00025	COG0861	Integral membrane protein TerC family
HW35_RS00030	COG1183	phosphatidylcholine synthase activity
HW35_RS00035	COG1132	(ABC) transporter
HW35_RS00055	COG0307	riboflavin synthase, alpha
HW35_RS00060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW35_RS00060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW35_RS00065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HW35_RS00070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW35_RS00075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_RS00080	COG1120	ATPase activity
HW35_RS00085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HW35_RS00095	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HW35_RS00100	COG1492	cobalamin metabolic process
HW35_RS00105	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HW35_RS00120	COG2096	Adenosyltransferase
HW35_RS00135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW35_RS00150	COG0697	spore germination
HW35_RS00160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW35_RS00165	COG1247	-acetyltransferase
HW35_RS00180	COG1360	Flagellar Motor Protein
HW35_RS00185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW35_RS00190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW35_RS00195	COG2201	protein-glutamate methylesterase activity
HW35_RS00205	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HW35_RS00210	COG4786	Flagellar basal body rod
HW35_RS00215	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW35_RS00220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW35_RS00220	COG1776	CheC inhibitor of MCP methylation
HW35_RS00225	COG2201	protein-glutamate methylesterase activity
HW35_RS00230	COG0643	Histidine kinase
HW35_RS00230	COG2198	Histidine kinase
HW35_RS00235	COG0835	chemotaxis
HW35_RS00240	COG0835	chemotaxis
HW35_RS00245	COG1728	Protein conserved in bacteria
HW35_RS00255	COG4786	Flagellar basal body rod
HW35_RS00260	COG4786	Flagellar basal body rod
HW35_RS00265	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HW35_RS00270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HW35_RS00275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW35_RS00305	COG3344	reverse transcriptase
HW35_RS00320	COG4974	Belongs to the 'phage' integrase family
HW35_RS00365	COG1334	flagellar protein FlaG
HW35_RS00375	COG0840	transmembrane signaling receptor activity
HW35_RS00395	COG1256	bacterial-type flagellum assembly
HW35_RS00395	COG4786	Flagellar basal body rod
HW35_RS00400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW35_RS00405	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HW35_RS00415	COG1516	flagellar protein fliS
HW35_RS00435	COG1815	bacterial-type flagellum-dependent cell motility
HW35_RS00440	COG1558	bacterial-type flagellum-dependent cell motility
HW35_RS00450	COG1766	The M ring may be actively involved in energy transduction
HW35_RS00455	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW35_RS00465	COG1157	protein secretion by the type III secretion system
HW35_RS00485	COG1338	Plays a role in the flagellum-specific transport system
HW35_RS00490	COG1987	bacterial-type flagellum assembly
HW35_RS00495	COG1684	flagellar biosynthetic protein fliR
HW35_RS00500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW35_RS00505	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW35_RS00510	COG1419	protein localization to endoplasmic reticulum
HW35_RS00515	COG0455	bacterial-type flagellum organization
HW35_RS00525	COG1191	sigma factor activity
HW35_RS00530	COG1227	inorganic diphosphatase activity
HW35_RS00535	COG0519	Catalyzes the synthesis of GMP from XMP
HW35_RS00550	COG2217	Heavy metal translocating P-type atpase
HW35_RS00565	COG2608	mercury ion transmembrane transporter activity
HW35_RS00570	COG2801	Transposase and inactivated derivatives
HW35_RS00580	COG2270	Major facilitator Superfamily
HW35_RS00590	COG3344	reverse transcriptase
HW35_RS00605	COG3344	reverse transcriptase
HW35_RS00615	COG0438	transferase activity, transferring glycosyl groups
HW35_RS00625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW35_RS00630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HW35_RS00635	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HW35_RS00640	COG0351	phosphomethylpyrimidine kinase
HW35_RS00645	COG0352	thiamine-phosphate diphosphorylase activity
HW35_RS00655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW35_RS00660	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HW35_RS00665	COG1116	anion transmembrane transporter activity
HW35_RS00670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW35_RS00675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW35_RS00690	COG0534	Mate efflux family protein
HW35_RS00700	COG2267	carboxylic ester hydrolase activity
HW35_RS00710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW35_RS00725	COG3594	Acyltransferase
HW35_RS00735	COG2247	cell wall binding repeat
HW35_RS00735	COG2385	sporulation resulting in formation of a cellular spore
HW35_RS00745	COG0477	Major facilitator Superfamily
HW35_RS00755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW35_RS00760	COG0217	transcriptional regulatory protein
HW35_RS00765	COG0697	spore germination
HW35_RS00770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW35_RS00775	COG0456	acetyltransferase
HW35_RS00790	COG2135	peptidase activity
HW35_RS00800	COG2188	Transcriptional regulator
HW35_RS00805	COG0366	Alpha amylase catalytic
HW35_RS00810	COG1263	PTS System
HW35_RS00810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW35_RS00815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW35_RS00825	COG2814	Major facilitator Superfamily
HW35_RS00830	COG0488	(ABC) transporter
HW35_RS00845	COG2233	PERMEase
HW35_RS00850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW35_RS00870	COG0709	Synthesizes selenophosphate from selenide and ATP
HW35_RS00880	COG1921	L-seryl-tRNASec selenium transferase activity
HW35_RS00895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW35_RS00900	COG0488	(ABC) transporter
HW35_RS00905	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HW35_RS00915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW35_RS00935	COG0464	growth
HW35_RS00940	COG0824	Thioesterase
HW35_RS00950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HW35_RS00955	COG1832	CoA-binding protein
HW35_RS00960	COG0187	DNA topoisomerase II activity
HW35_RS00965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW35_RS00980	COG4974	Belongs to the 'phage' integrase family
HW35_RS01010	COG5577	PFAM Coat F domain
HW35_RS01015	COG1368	sulfuric ester hydrolase activity
HW35_RS01030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW35_RS01035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW35_RS01040	COG1012	belongs to the aldehyde dehydrogenase family
HW35_RS01045	COG3829	transcription factor binding
HW35_RS01050	COG3384	dioxygenase
HW35_RS01065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HW35_RS01070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HW35_RS01075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW35_RS01080	COG1012	belongs to the aldehyde dehydrogenase family
HW35_RS01085	COG3835	regulator
HW35_RS01105	COG0167	dihydroorotate dehydrogenase activity
HW35_RS01110	COG0493	'glutamate synthase
HW35_RS01115	COG1587	Uroporphyrinogen-III synthase
HW35_RS01120	COG2814	Major facilitator Superfamily
HW35_RS01135	COG2720	vancomycin resistance protein
HW35_RS01150	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW35_RS01155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HW35_RS01160	COG0583	DNA-binding transcription factor activity
HW35_RS01190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HW35_RS01195	COG0454	-acetyltransferase
HW35_RS01195	COG0456	acetyltransferase
HW35_RS01205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW35_RS01225	COG3647	Membrane
HW35_RS01235	COG3773	Cell wall hydrolase
HW35_RS01245	COG0653	protein targeting
HW35_RS01250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW35_RS01255	COG0583	DNA-binding transcription factor activity
HW35_RS01260	COG3773	Cell wall hydrolase
HW35_RS01265	COG1116	anion transmembrane transporter activity
HW35_RS01270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW35_RS01275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW35_RS01280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW35_RS01285	COG0431	NADPH-dependent FMN reductase
HW35_RS01305	COG0720	synthase
HW35_RS01315	COG2031	fatty acid transporter
HW35_RS01320	COG3314	Sporulation integral membrane protein YlbJ
HW35_RS01345	COG0730	response to heat
HW35_RS01350	COG0425	Belongs to the sulfur carrier protein TusA family
HW35_RS01355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW35_RS01355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW35_RS01360	COG0425	Belongs to the sulfur carrier protein TusA family
HW35_RS01360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW35_RS01365	COG2210	Belongs to the sulfur carrier protein TusA family
HW35_RS01370	COG1937	Protein conserved in bacteria
HW35_RS01405	COG3800	Transcriptional regulator
HW35_RS01405	COG1396	sequence-specific DNA binding
HW35_RS01455	COG1695	Transcriptional regulator
HW35_RS01465	COG0305	Participates in initiation and elongation during chromosome replication
HW35_RS01480	COG1309	transcriptional regulator
HW35_RS01490	COG2309	aminopeptidase activity
HW35_RS01520	COG0656	L-ascorbic acid biosynthetic process
HW35_RS01525	COG2814	Major facilitator Superfamily
HW35_RS01530	COG1733	regulation of RNA biosynthetic process
HW35_RS01560	COG1525	nuclease
HW35_RS01570	COG0010	Belongs to the arginase family
HW35_RS01575	COG1228	amidohydrolase
HW35_RS01580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HW35_RS01585	COG1757	Na H antiporter
HW35_RS01590	COG1418	mRNA catabolic process
HW35_RS01600	COG2226	methyltransferase
HW35_RS01620	COG2839	Protein conserved in bacteria
HW35_RS01665	COG3773	Cell wall hydrolase
HW35_RS01675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW35_RS01680	COG1309	transcriptional regulator
HW35_RS01690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HW35_RS01695	COG0235	Class ii aldolase
HW35_RS01700	COG0402	S-adenosylhomocysteine deaminase activity
HW35_RS01705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HW35_RS01710	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HW35_RS01715	COG1122	ATPase activity
HW35_RS01725	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW35_RS01730	COG1609	Transcriptional regulator
HW35_RS01740	COG0697	spore germination
HW35_RS01750	COG1414	Transcriptional regulator
HW35_RS01760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HW35_RS01765	COG0277	FAD linked oxidase domain protein
HW35_RS01770	COG0247	lactate metabolic process
HW35_RS01775	COG0277	FAD linked oxidase domain protein
HW35_RS01780	COG0716	FMN binding
HW35_RS01785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW35_RS01790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW35_RS01795	COG0671	phosphoesterase, PA-phosphatase related
HW35_RS01810	COG0024	Methionine aminopeptidase
HW35_RS01820	COG1011	Hydrolase
HW35_RS01825	COG1114	Component of the transport system for branched-chain amino acids
HW35_RS01845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW35_RS01850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW35_RS01865	COG2027	D-alanyl-D-alanine carboxypeptidase
HW35_RS01870	COG3858	chitin binding
HW35_RS01900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW35_RS01900	COG0574	Belongs to the PEP-utilizing enzyme family
HW35_RS01905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HW35_RS01985	COG0708	Exodeoxyribonuclease III
HW35_RS01990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW35_RS02005	COG1657	PFAM Prenyltransferase squalene oxidase
HW35_RS02010	COG5002	protein histidine kinase activity
HW35_RS02010	COG3850	Histidine kinase
HW35_RS02015	COG0745	RESPONSE REGULATOR receiver
HW35_RS02025	COG2720	vancomycin resistance protein
HW35_RS02035	COG2226	methyltransferase
HW35_RS02045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_RS02060	COG2323	membrane
HW35_RS02065	COG0697	spore germination
HW35_RS02070	COG0833	amino acid
HW35_RS02075	COG0706	membrane insertase activity
HW35_RS02105	COG0017	Asparaginyl-tRNA synthetase
HW35_RS02120	COG3973	AAA domain
HW35_RS02140	COG0789	Transcriptional regulator
HW35_RS02145	COG0457	Tetratricopeptide repeat
HW35_RS02145	COG0463	Glycosyl transferase, family 2
HW35_RS02155	COG0463	Glycosyl transferase, family 2
HW35_RS02230	COG0527	aspartate kinase activity
HW35_RS02235	COG0494	nUDIX hydrolase
HW35_RS02240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW35_RS02255	COG1368	sulfuric ester hydrolase activity
HW35_RS02270	COG3344	reverse transcriptase
HW35_RS02290	COG0569	domain protein
HW35_RS02295	COG2223	nitrite transmembrane transporter activity
HW35_RS02300	COG2223	nitrite transmembrane transporter activity
HW35_RS02310	COG5002	protein histidine kinase activity
HW35_RS02315	COG3344	reverse transcriptase
HW35_RS02325	COG0488	(ABC) transporter
HW35_RS02335	COG4149	molybdate abc transporter
HW35_RS02340	COG1686	Belongs to the peptidase S11 family
HW35_RS02345	COG0392	lysyltransferase activity
HW35_RS02345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HW35_RS02355	COG1882	Formate acetyltransferase
HW35_RS02360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HW35_RS02365	COG0706	membrane insertase activity
HW35_RS02375	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_RS02395	COG0135	phosphoribosylanthranilate isomerase activity
HW35_RS02410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW35_RS02410	COG0512	Glutamine amidotransferase of anthranilate synthase
HW35_RS02415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW35_RS02420	COG2814	Major facilitator Superfamily
HW35_RS02425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_RS02425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW35_RS02425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW35_RS02430	COG1105	Belongs to the carbohydrate kinase PfkB family
HW35_RS02435	COG1349	DNA-binding transcription factor activity
HW35_RS02445	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HW35_RS02450	COG1793	dna ligase
HW35_RS02450	COG3285	dna ligase
HW35_RS02455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HW35_RS02475	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_RS02505	COG3409	Peptidoglycan-binding domain 1 protein
HW35_RS02505	COG0793	Belongs to the peptidase S41A family
HW35_RS02510	COG0813	purine-nucleoside phosphorylase activity
HW35_RS02520	COG4326	sporulation control protein
HW35_RS02530	COG4479	Belongs to the UPF0346 family
HW35_RS02540	COG1509	lysine 2,3-aminomutase activity
HW35_RS02545	COG3829	transcription factor binding
HW35_RS02550	COG0456	acetyltransferase
HW35_RS02555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW35_RS02560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW35_RS02565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW35_RS02570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW35_RS02575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW35_RS02590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW35_RS02595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW35_RS02605	COG2755	lipolytic protein G-D-S-L family
HW35_RS02610	COG1999	signal sequence binding
HW35_RS02630	COG0681	Belongs to the peptidase S26 family
HW35_RS02645	COG1396	sequence-specific DNA binding
HW35_RS02650	COG0805	protein transport
HW35_RS02655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW35_RS02665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW35_RS02670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HW35_RS02680	COG2310	stress, protein
HW35_RS02685	COG2310	stress, protein
HW35_RS02690	COG3853	Toxic anion resistance protein (TelA)
HW35_RS02705	COG0861	Integral membrane protein TerC family
HW35_RS02710	COG2310	stress, protein
HW35_RS02720	COG1413	lyase activity
HW35_RS02725	COG0488	(ABC) transporter
HW35_RS02730	COG1418	mRNA catabolic process
HW35_RS02755	COG2801	Transposase and inactivated derivatives
HW35_RS02765	COG1321	iron dependent repressor
HW35_RS02770	COG0551	DNA topoisomerase type I activity
HW35_RS02770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW35_RS02780	COG1278	Cold shock
HW35_RS02790	COG0328	RNA-DNA hybrid ribonuclease activity
HW35_RS02805	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HW35_RS02815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW35_RS02820	COG2897	thiosulfate sulfurtransferase activity
HW35_RS02825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HW35_RS02830	COG1755	Isoprenylcysteine carboxyl methyltransferase
HW35_RS02835	COG3424	synthase
HW35_RS02850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW35_RS02885	COG1199	ATP-dependent helicase activity
HW35_RS02890	COG0116	Belongs to the methyltransferase superfamily
HW35_RS02900	COG4474	Belongs to the UPF0398 family
HW35_RS02910	COG3359	exonuclease
HW35_RS02915	COG1205	dead DEAH box helicase
HW35_RS02915	COG1111	helicase
HW35_RS02920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW35_RS02925	COG0071	Belongs to the small heat shock protein (HSP20) family
HW35_RS02970	COG3331	DNA recombination
HW35_RS02980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW35_RS02985	COG3935	DnaD domain protein
HW35_RS03005	COG1199	ATP-dependent helicase activity
HW35_RS03005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW35_RS03010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HW35_RS03015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HW35_RS03030	COG0617	tRNA 3'-terminal CCA addition
HW35_RS03035	COG0438	transferase activity, transferring glycosyl groups
HW35_RS03040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW35_RS03045	COG1803	Methylglyoxal synthase
HW35_RS03055	COG1694	Mazg nucleotide pyrophosphohydrolase
HW35_RS03060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_RS03065	COG2738	Putative neutral zinc metallopeptidase
HW35_RS03075	COG4347	Protein of unknown function (DUF1405)
HW35_RS03085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HW35_RS03100	COG5582	Belongs to the UPF0302 family
HW35_RS03105	COG0457	Tetratricopeptide repeat
HW35_RS03115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW35_RS03120	COG0287	Prephenate dehydrogenase
HW35_RS03125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW35_RS03130	COG4401	Chorismate mutase type I
HW35_RS03135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HW35_RS03145	COG0105	UTP biosynthetic process
HW35_RS03150	COG0142	geranyltranstransferase activity
HW35_RS03155	COG2226	methyltransferase
HW35_RS03160	COG0142	geranyltranstransferase activity
HW35_RS03170	COG0302	gtp cyclohydrolase
HW35_RS03175	COG0776	regulation of translation
HW35_RS03180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HW35_RS03200	COG1160	GTP binding
HW35_RS03215	COG1304	FMN binding
HW35_RS03220	COG0539	negative regulation of cytoplasmic translation
HW35_RS03230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HW35_RS03240	COG2959	enzyme of heme biosynthesis
HW35_RS03250	COG2339	peptidase activity
HW35_RS03260	COG0492	ferredoxin-NADP+ reductase activity
HW35_RS03265	COG3344	reverse transcriptase
HW35_RS03270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW35_RS03275	COG4862	establishment of competence for transformation
HW35_RS03290	COG3546	catalase activity
HW35_RS03305	COG1266	CAAX protease self-immunity
HW35_RS03310	COG0514	ATP-dependent DNA helicase (RecQ)
HW35_RS03315	COG4955	Helix-turn-helix domain
HW35_RS03325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HW35_RS03330	COG3942	CHAP domain
HW35_RS03330	COG1388	LysM domain
HW35_RS03340	COG1595	DNA-templated transcription, initiation
HW35_RS03350	COG5002	protein histidine kinase activity
HW35_RS03355	COG0745	RESPONSE REGULATOR receiver
HW35_RS03360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW35_RS03365	COG1333	cytochrome c biogenesis protein
HW35_RS03370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW35_RS03375	COG1187	pseudouridine synthase activity
HW35_RS03380	COG0700	Nucleoside recognition
HW35_RS03385	COG2715	membrane protein required for spore maturation
HW35_RS03390	COG1686	Belongs to the peptidase S11 family
HW35_RS03395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HW35_RS03410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW35_RS03415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HW35_RS03425	COG1547	Domain of unknown function (DUF309)
HW35_RS03435	COG4086	secreted protein
HW35_RS03445	COG0697	spore germination
HW35_RS03470	COG2172	sigma factor antagonist activity
HW35_RS03480	COG1686	Belongs to the peptidase S11 family
HW35_RS03500	COG4974	Belongs to the 'phage' integrase family
HW35_RS03515	COG0735	belongs to the Fur family
HW35_RS03520	COG1300	Membrane
HW35_RS03535	COG1379	DNA repair
HW35_RS03545	COG0667	Aldo Keto reductase
HW35_RS03555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW35_RS03560	COG1073	alpha beta
HW35_RS03585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW35_RS03595	COG0300	oxidoreductase activity
HW35_RS03600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW35_RS03605	COG1902	pentaerythritol trinitrate reductase activity
HW35_RS03610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW35_RS03615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW35_RS03620	COG1234	tRNA 3'-trailer cleavage
HW35_RS03625	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW35_RS03630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW35_RS03635	COG0346	lactoylglutathione lyase activity
HW35_RS03645	COG1703	isobutyryl-CoA mutase activity
HW35_RS03650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_RS03650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_RS03655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_RS03660	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW35_RS03665	COG0022	dehydrogenase e1 component
HW35_RS03670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW35_RS03675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW35_RS03690	COG0280	phosphate acetyltransferase
HW35_RS03695	COG3290	protein histidine kinase activity
HW35_RS03695	COG3829	transcription factor binding
HW35_RS03710	COG0584	glycerophosphoryl diester phosphodiesterase
HW35_RS03720	COG0750	zinc metalloprotease
HW35_RS03725	COG0497	DNA recombination
HW35_RS03730	COG1438	arginine binding
HW35_RS03735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HW35_RS03745	COG1722	exodeoxyribonuclease VII activity
HW35_RS03750	COG1570	exodeoxyribonuclease VII activity
HW35_RS03755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW35_RS03765	COG1302	Protein conserved in bacteria
HW35_RS03770	COG0439	Biotin carboxylase
HW35_RS03775	COG0511	ligase activity, forming carbon-carbon bonds
HW35_RS03820	COG3854	ATPases associated with a variety of cellular activities
HW35_RS03835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HW35_RS03840	COG0006	proline dipeptidase activity
HW35_RS03850	COG3872	metal-dependent enzyme
HW35_RS03860	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW35_RS03875	COG5002	protein histidine kinase activity
HW35_RS03875	COG3850	Histidine kinase
HW35_RS03880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW35_RS03895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW35_RS03910	COG0095	Lipoate-protein ligase
HW35_RS03915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW35_RS03920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW35_RS03925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW35_RS03930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW35_RS03935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW35_RS03965	COG4970	Tfp pilus assembly protein FimT
HW35_RS03970	COG4537	Required for transformation and DNA binding
HW35_RS03975	COG1459	type II secretion system
HW35_RS03980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW35_RS04000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW35_RS04015	COG1940	carbohydrate kinase activity
HW35_RS04020	COG4483	Protein conserved in bacteria
HW35_RS04035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW35_RS04040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW35_RS04060	COG0704	Plays a role in the regulation of phosphate uptake
HW35_RS04075	COG0573	inorganic phosphate transmembrane transporter activity
HW35_RS04080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HW35_RS04085	COG0768	penicillin binding
HW35_RS04090	COG0477	Major facilitator Superfamily
HW35_RS04100	COG5521	maltodextrose utilization protein MalA
HW35_RS04110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HW35_RS04115	COG4709	membrane
HW35_RS04120	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HW35_RS04125	COG0735	belongs to the Fur family
HW35_RS04130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW35_RS04135	COG1121	(ABC) transporter
HW35_RS04145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HW35_RS04150	COG0513	Belongs to the DEAD box helicase family
HW35_RS04160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HW35_RS04165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW35_RS04170	COG2384	SAM-dependent methyltransferase
HW35_RS04175	COG2010	Cytochrome c
HW35_RS04180	COG1960	acyl-CoA dehydrogenase activity
HW35_RS04185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW35_RS04190	COG0358	DNA primase activity
HW35_RS04195	COG1671	Belongs to the UPF0178 family
HW35_RS04205	COG0517	IMP dehydrogenase activity
HW35_RS04215	COG2801	Transposase and inactivated derivatives
HW35_RS04220	COG0423	glycine-tRNA ligase activity
HW35_RS04225	COG1381	Involved in DNA repair and RecF pathway recombination
HW35_RS04230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HW35_RS04235	COG0295	cytidine deaminase activity
HW35_RS04240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HW35_RS04250	COG1480	7TM receptor with intracellular HD hydrolase
HW35_RS04255	COG1702	phosphate starvation-inducible protein PhoH
HW35_RS04270	COG1610	YqeY-like protein
HW35_RS04275	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HW35_RS04285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW35_RS04290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW35_RS04295	COG2264	protein methyltransferase activity
HW35_RS04300	COG0484	heat shock protein binding
HW35_RS04305	COG0443	Heat shock 70 kDa protein
HW35_RS04310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW35_RS04315	COG1420	regulation of RNA biosynthetic process
HW35_RS04320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW35_RS04325	COG0481	GTPase activity
HW35_RS04335	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW35_RS04345	COG0268	Binds directly to 16S ribosomal RNA
HW35_RS04355	COG1466	dna polymerase III delta subunit
HW35_RS04365	COG0658	competence protein
HW35_RS04365	COG2333	competence protein COMEC
HW35_RS04370	COG2131	deaminase
HW35_RS04375	COG1596	polysaccharide export
HW35_RS04375	COG1555	photosystem II stabilization
HW35_RS04380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW35_RS04385	COG3344	reverse transcriptase
HW35_RS04390	COG2226	methyltransferase
HW35_RS04395	COG0799	negative regulation of ribosome biogenesis
HW35_RS04400	COG1713	HD superfamily hydrolase involved in NAD metabolism
HW35_RS04405	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW35_RS04410	COG1534	Rna-binding protein
HW35_RS04420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HW35_RS04425	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HW35_RS04435	COG0688	phosphatidylethanolamine metabolic process
HW35_RS04440	COG1183	phosphatidylcholine synthase activity
HW35_RS04455	COG0626	cystathionine gamma-synthase activity
HW35_RS04460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW35_RS04465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW35_RS04475	COG0768	penicillin binding
HW35_RS04480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW35_RS04485	COG0572	uridine kinase
HW35_RS04490	COG0826	peptidase U32
HW35_RS04495	COG0826	peptidase U32
HW35_RS04500	COG4122	O-methyltransferase activity
HW35_RS04505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW35_RS04510	COG3906	Belongs to the UPF0473 family
HW35_RS04515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HW35_RS04520	COG4472	Bacterial protein of unknown function (DUF965)
HW35_RS04525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW35_RS04530	COG0628	permease
HW35_RS04545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW35_RS04560	COG1104	cysteine desulfurase activity
HW35_RS04565	COG1959	2 iron, 2 sulfur cluster binding
HW35_RS04570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW35_RS04580	COG4841	protein insertion into membrane
HW35_RS04585	COG1879	ABC-type sugar transport system periplasmic component
HW35_RS04590	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW35_RS04595	COG1129	ABC transporter
HW35_RS04600	COG1869	D-ribose catabolic process
HW35_RS04605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW35_RS04610	COG1609	Transcriptional regulator
HW35_RS04615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HW35_RS04620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HW35_RS04625	COG0124	histidyl-tRNA synthetase
HW35_RS04635	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW35_RS04635	COG4991	sh3 domain protein
HW35_RS04635	COG3103	Sh3 type 3 domain protein
HW35_RS04640	COG1490	D-aminoacyl-tRNA deacylase activity
HW35_RS04645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW35_RS04650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW35_RS04655	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HW35_RS04655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW35_RS04665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW35_RS04665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW35_RS04675	COG2244	polysaccharide biosynthetic process
HW35_RS04680	COG2323	membrane
HW35_RS04690	COG1862	Preprotein translocase
HW35_RS04700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HW35_RS04710	COG2255	four-way junction helicase activity
HW35_RS04715	COG0632	four-way junction helicase activity
HW35_RS04740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HW35_RS04745	COG0157	Belongs to the NadC ModD family
HW35_RS04750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HW35_RS04755	COG1104	cysteine desulfurase activity
HW35_RS04760	COG1827	regulation of RNA biosynthetic process
HW35_RS04765	COG0077	Prephenate dehydratase
HW35_RS04770	COG4492	Belongs to the UPF0735 family
HW35_RS04775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW35_RS04780	COG3290	protein histidine kinase activity
HW35_RS04785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HW35_RS04790	COG2868	ribosomal protein
HW35_RS04795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HW35_RS04805	COG1994	Peptidase M50
HW35_RS04810	COG0739	heme binding
HW35_RS04815	COG2894	cell division
HW35_RS04820	COG0850	regulation of cytokinetic process
HW35_RS04830	COG1792	Involved in formation and maintenance of cell shape
HW35_RS04835	COG1077	Cell shape determining protein MreB Mrl
HW35_RS04840	COG2003	Belongs to the UPF0758 family
HW35_RS04870	COG1459	type II secretion system
HW35_RS04880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW35_RS04900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HW35_RS04910	COG3706	GGDEF domain
HW35_RS04915	COG0285	dihydrofolate synthase activity
HW35_RS04935	COG1388	LysM domain
HW35_RS04935	COG1388	LysM domain
HW35_RS04950	COG3344	reverse transcriptase
HW35_RS04955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW35_RS04960	COG0113	porphobilinogen synthase activity
HW35_RS04970	COG0181	hydroxymethylbilane synthase activity
HW35_RS04975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW35_RS04990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HW35_RS04995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW35_RS05000	COG1067	ATP-dependent peptidase activity
HW35_RS05000	COG0470	DNA polymerase III
HW35_RS05010	COG0544	peptidyl-prolyl cis-trans isomerase activity
HW35_RS05025	COG1131	(ABC) transporter
HW35_RS05055	COG2801	Transposase and inactivated derivatives
HW35_RS05070	COG0622	Phosphoesterase
HW35_RS05075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HW35_RS05080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HW35_RS05085	COG5401	PFAM Sporulation and spore germination
HW35_RS05095	COG1846	Transcriptional regulator
HW35_RS05100	COG3344	reverse transcriptase
HW35_RS05125	COG2197	response regulator
HW35_RS05130	COG3764	Sortase (surface protein transpeptidase)
HW35_RS05135	COG3344	reverse transcriptase
HW35_RS05140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW35_RS05145	COG1053	succinate dehydrogenase
HW35_RS05150	COG2009	succinate dehydrogenase
HW35_RS05155	COG1719	4-vinyl reductase, 4VR
HW35_RS05165	COG0322	excinuclease ABC activity
HW35_RS05170	COG3118	belongs to the thioredoxin family
HW35_RS05175	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW35_RS05180	COG2086	electron transfer activity
HW35_RS05185	COG1024	Enoyl-CoA hydratase
HW35_RS05190	COG1309	transcriptional regulator
HW35_RS05195	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_RS05200	COG3766	membrane
HW35_RS05205	COG1193	negative regulation of DNA recombination
HW35_RS05210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW35_RS05210	COG1796	DNA polymerase
HW35_RS05215	COG1286	toxin biosynthetic process
HW35_RS05220	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HW35_RS05225	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HW35_RS05245	COG0072	phenylalanine-tRNA ligase activity
HW35_RS05245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW35_RS05250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HW35_RS05255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW35_RS05265	COG1363	Peptidase, m42
HW35_RS05275	COG3326	Membrane
HW35_RS05280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HW35_RS05285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW35_RS05290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HW35_RS05295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW35_RS05305	COG1484	DNA-dependent DNA replication
HW35_RS05310	COG3611	Membrane attachment protein
HW35_RS05315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW35_RS05325	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HW35_RS05330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW35_RS05335	COG0237	dephospho-CoA kinase activity
HW35_RS05340	COG1971	Probably functions as a manganese efflux pump
HW35_RS05345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW35_RS05350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW35_RS05350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW35_RS05355	COG5002	protein histidine kinase activity
HW35_RS05360	COG0745	RESPONSE REGULATOR receiver
HW35_RS05365	COG3344	reverse transcriptase
HW35_RS05380	COG0039	L-malate dehydrogenase activity
HW35_RS05385	COG0538	isocitrate dehydrogenase activity
HW35_RS05390	COG0372	Belongs to the citrate synthase family
HW35_RS05395	COG2707	UPF0756 membrane protein
HW35_RS05400	COG0628	permease
HW35_RS05410	COG0205	6-phosphofructokinase activity
HW35_RS05415	COG0825	malonyl-CoA metabolic process
HW35_RS05420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HW35_RS05425	COG2186	Transcriptional regulator
HW35_RS05430	COG0281	malic enzyme
HW35_RS05435	COG0587	DNA-directed DNA polymerase activity
HW35_RS05450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HW35_RS05460	COG4109	DRTGG domain
HW35_RS05470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HW35_RS05475	COG0006	proline dipeptidase activity
HW35_RS05485	COG0589	response to stress
HW35_RS05505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW35_RS05510	COG0827	DNA restriction-modification system
HW35_RS05515	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HW35_RS05520	COG3874	Sporulation protein YtfJ
HW35_RS05530	COG1714	RDD family
HW35_RS05535	COG0616	signal peptide processing
HW35_RS05540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HW35_RS05545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW35_RS05560	COG0301	tRNA thio-modification
HW35_RS05565	COG1104	cysteine desulfurase activity
HW35_RS05570	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HW35_RS05575	COG1309	transcriptional regulator
HW35_RS05580	COG1956	GAF domain-containing protein
HW35_RS05590	COG2199	diguanylate cyclase activity
HW35_RS05590	COG2203	Gaf domain
HW35_RS05595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HW35_RS05605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HW35_RS05610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW35_RS05615	COG0454	-acetyltransferase
HW35_RS05620	COG0517	IMP dehydrogenase activity
HW35_RS05625	COG0123	including yeast histone deacetylase and acetoin utilization protein
HW35_RS05630	COG1609	Transcriptional regulator
HW35_RS05635	COG1605	Chorismate mutase
HW35_RS05635	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HW35_RS05640	COG3118	belongs to the thioredoxin family
HW35_RS05655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW35_RS05660	COG1674	ftsk spoiiie
HW35_RS05665	COG4848	Belongs to the UPF0354 family
HW35_RS05670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW35_RS05675	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HW35_RS05680	COG1363	Peptidase, m42
HW35_RS05690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW35_RS05695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HW35_RS05705	COG0510	thiamine kinase activity
HW35_RS05710	COG1523	belongs to the glycosyl hydrolase 13 family
HW35_RS05715	COG1597	lipid kinase activity
HW35_RS05725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW35_RS05740	COG3344	reverse transcriptase
HW35_RS05755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW35_RS05760	COG1349	DNA-binding transcription factor activity
HW35_RS05770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW35_RS05785	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HW35_RS05790	COG0783	Belongs to the Dps family
HW35_RS05795	COG1187	pseudouridine synthase activity
HW35_RS05800	COG2244	polysaccharide biosynthetic process
HW35_RS05805	COG2081	HI0933 family
HW35_RS05815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW35_RS05820	COG0495	leucyl-tRNA aminoacylation
HW35_RS05825	COG2814	Major facilitator Superfamily
HW35_RS05840	COG1242	4 iron, 4 sulfur cluster binding
HW35_RS05845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HW35_RS05855	COG2267	carboxylic ester hydrolase activity
HW35_RS05860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW35_RS05865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HW35_RS05880	COG1506	peptidase
HW35_RS05885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW35_RS05890	COG1116	anion transmembrane transporter activity
HW35_RS05895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW35_RS05900	COG0450	alkyl hydroperoxide reductase
HW35_RS05910	COG0561	phosphatase activity
HW35_RS05935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW35_RS05955	COG2801	Transposase and inactivated derivatives
HW35_RS05970	COG1131	(ABC) transporter
HW35_RS06010	COG2252	PERMEase
HW35_RS06015	COG1404	Belongs to the peptidase S8 family
HW35_RS06020	COG1279	arginine transmembrane transporter activity
HW35_RS06025	COG0494	nUDIX hydrolase
HW35_RS06040	COG1854	S-ribosylhomocysteine lyase activity
HW35_RS06045	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HW35_RS06050	COG0288	reversible hydration of carbon dioxide
HW35_RS06060	COG4948	Mandelate Racemase Muconate Lactonizing
HW35_RS06065	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_RS06070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW35_RS06075	COG0596	Alpha beta hydrolase
HW35_RS06080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HW35_RS06085	COG1169	isochorismate synthase
HW35_RS06090	COG1575	Belongs to the MenA family. Type 1 subfamily
HW35_RS06095	COG0058	SHG alpha-glucan phosphorylase activity
HW35_RS06100	COG0297	glycogen (starch) synthase activity
HW35_RS06105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HW35_RS06240	COG1285	pathogenesis
HW35_RS06250	COG3162	membrane
HW35_RS06255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW35_RS06270	COG0083	homoserine kinase activity
HW35_RS06275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HW35_RS06280	COG0460	homoserine dehydrogenase
HW35_RS06285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW35_RS06295	COG0840	transmembrane signaling receptor activity
HW35_RS06305	COG3773	Cell wall hydrolase
HW35_RS06310	COG0783	Belongs to the Dps family
HW35_RS06320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HW35_RS06325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW35_RS06330	COG2706	6-phosphogluconolactonase activity
HW35_RS06335	COG0626	cystathionine gamma-synthase activity
HW35_RS06340	COG0626	cystathionine gamma-synthase activity
HW35_RS06345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HW35_RS06345	COG0646	methionine synthase
HW35_RS06350	COG1410	methionine synthase
HW35_RS06350	COG0646	methionine synthase
HW35_RS06360	COG2814	Major facilitator Superfamily
HW35_RS06365	COG0492	ferredoxin-NADP+ reductase activity
HW35_RS06370	COG0346	lactoylglutathione lyase activity
HW35_RS06380	COG2801	Transposase and inactivated derivatives
HW35_RS06400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW35_RS06410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW35_RS06415	COG1113	amino acid transport
HW35_RS06420	COG1280	lysine exporter protein (LysE YggA)
HW35_RS06425	COG0463	Glycosyl transferase, family 2
HW35_RS06455	COG1979	alcohol dehydrogenase
HW35_RS06465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW35_RS06475	COG1098	S1 RNA binding domain
HW35_RS06480	COG1396	sequence-specific DNA binding
HW35_RS06490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HW35_RS06495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HW35_RS06515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW35_RS06525	COG5018	Exonuclease
HW35_RS06530	COG2050	protein possibly involved in aromatic compounds catabolism
HW35_RS06540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW35_RS06545	COG3584	3D domain protein
HW35_RS06555	COG1252	NADH dehydrogenase
HW35_RS06570	COG0316	Belongs to the HesB IscA family
HW35_RS06575	COG4844	belongs to the
HW35_RS06580	COG1252	NADH dehydrogenase
HW35_RS06585	COG4837	Protein of unknown function (DUF1462)
HW35_RS06590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HW35_RS06595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW35_RS06600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW35_RS06605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW35_RS06610	COG0647	UMP catabolic process
HW35_RS06615	COG2445	Protein of unknown function DUF86
HW35_RS06630	COG4470	Protein conserved in bacteria
HW35_RS06640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HW35_RS06645	COG0739	heme binding
HW35_RS06655	COG3377	Domain of unknown function (DUF1805)
HW35_RS06660	COG0730	response to heat
HW35_RS06665	COG1801	Protein of unknown function DUF72
HW35_RS06670	COG2801	Transposase and inactivated derivatives
HW35_RS06685	COG0719	Fe-S assembly protein
HW35_RS06690	COG0822	iron-sulfur transferase activity
HW35_RS06695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW35_RS06700	COG0719	Fe-S assembly protein
HW35_RS06705	COG0396	ATPase activity
HW35_RS06710	COG1464	Belongs to the NlpA lipoprotein family
HW35_RS06715	COG2011	ABC-type metal ion transport system permease component
HW35_RS06720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW35_RS06740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW35_RS06745	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HW35_RS06750	COG0509	glycine decarboxylation via glycine cleavage system
HW35_RS06755	COG1393	Belongs to the ArsC family
HW35_RS06770	COG1960	acyl-CoA dehydrogenase activity
HW35_RS06775	COG0183	Belongs to the thiolase family
HW35_RS06780	COG1024	Enoyl-CoA hydratase
HW35_RS06780	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW35_RS06795	COG1120	ATPase activity
HW35_RS06800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_RS06805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_RS06810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW35_RS06815	COG0772	Belongs to the SEDS family
HW35_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_RS06835	COG2268	Band 7 protein
HW35_RS06840	COG1585	Membrane protein implicated in regulation of membrane protease activity
HW35_RS06850	COG1126	abc transporter atp-binding protein
HW35_RS06855	COG0765	amino acid transport
HW35_RS06860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW35_RS06865	COG0531	amino acid
HW35_RS06870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HW35_RS06875	COG1607	acyl-coa hydrolase
HW35_RS06890	COG0628	permease
HW35_RS06910	COG5577	PFAM Coat F domain
HW35_RS06960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HW35_RS06965	COG0557	exoribonuclease II activity
HW35_RS06970	COG1647	Serine aminopeptidase, S33
HW35_RS06975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW35_RS07000	COG0148	phosphopyruvate hydratase activity
HW35_RS07005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HW35_RS07015	COG0126	phosphoglycerate kinase activity
HW35_RS07035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HW35_RS07045	COG4641	Protein conserved in bacteria
HW35_RS07050	COG1086	Polysaccharide biosynthesis protein
HW35_RS07055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW35_RS07060	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HW35_RS07065	COG3980	spore coat polysaccharide biosynthesis protein
HW35_RS07075	COG2089	acid synthase
HW35_RS07080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HW35_RS07085	COG0463	Glycosyl transferase, family 2
HW35_RS07090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HW35_RS07095	COG1088	dTDP-glucose 4,6-dehydratase activity
HW35_RS07100	COG1091	dTDP-4-dehydrorhamnose reductase activity
HW35_RS07115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW35_RS07120	COG3002	Belongs to the UPF0753 family
HW35_RS07125	COG0288	reversible hydration of carbon dioxide
HW35_RS07130	COG5609	conserved protein (DUF2294)
HW35_RS07145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW35_RS07150	COG0569	domain protein
HW35_RS07190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_RS07195	COG1481	regulation of sporulation
HW35_RS07200	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HW35_RS07205	COG1660	Displays ATPase and GTPase activities
HW35_RS07210	COG1051	belongs to the nudix hydrolase family
HW35_RS07215	COG0492	ferredoxin-NADP+ reductase activity
HW35_RS07220	COG0457	Tetratricopeptide repeat
HW35_RS07230	COG0140	phosphoribosyl-ATP diphosphatase activity
HW35_RS07230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HW35_RS07235	COG0107	imidazoleglycerol-phosphate synthase activity
HW35_RS07240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HW35_RS07245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HW35_RS07250	COG0131	Imidazoleglycerol-phosphate dehydratase
HW35_RS07255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HW35_RS07260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HW35_RS07265	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HW35_RS07270	COG0110	maltose O-acetyltransferase activity
HW35_RS07280	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW35_RS07290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HW35_RS07295	COG1950	PFAM Membrane protein of
HW35_RS07300	COG3595	metallopeptidase activity
HW35_RS07305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW35_RS07310	COG0556	nucleotide-excision repair
HW35_RS07315	COG4897	Protein conserved in bacteria
HW35_RS07320	COG1115	amino acid carrier protein
HW35_RS07325	COG3876	Protein conserved in bacteria
HW35_RS07330	COG1472	Belongs to the glycosyl hydrolase 3 family
HW35_RS07335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW35_RS07350	COG1175	transmembrane transport
HW35_RS07360	COG1737	Transcriptional regulator
HW35_RS07370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW35_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW35_RS07390	COG0765	amino acid transport
HW35_RS07395	COG1126	abc transporter atp-binding protein
HW35_RS07410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW35_RS07415	COG0793	Belongs to the peptidase S41A family
HW35_RS07415	COG3409	Peptidoglycan-binding domain 1 protein
HW35_RS07420	COG0739	heme binding
HW35_RS07425	COG2177	Part of the ABC transporter FtsEX involved in
HW35_RS07430	COG2884	Cell division ATP-binding protein ftsE
HW35_RS07440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_RS07445	COG3344	reverse transcriptase
HW35_RS07450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW35_RS07455	COG0653	protein targeting
HW35_RS07465	COG2801	Transposase and inactivated derivatives
HW35_RS07475	COG1040	competence protein
HW35_RS07480	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HW35_RS07485	COG1307	EDD domain protein, DegV family
HW35_RS07490	COG2197	response regulator
HW35_RS07495	COG4585	Histidine kinase
HW35_RS07500	COG1739	Uncharacterized protein family UPF0029
HW35_RS07505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW35_RS07510	COG0737	Belongs to the 5'-nucleotidase family
HW35_RS07515	COG1316	TRANSCRIPTIONal
HW35_RS07540	COG2801	Transposase and inactivated derivatives
HW35_RS07550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW35_RS07555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW35_RS07560	COG0438	transferase activity, transferring glycosyl groups
HW35_RS07570	COG0438	transferase activity, transferring glycosyl groups
HW35_RS07580	COG2246	polysaccharide biosynthetic process
HW35_RS07590	COG3475	LICD family
HW35_RS07595	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HW35_RS07600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HW35_RS07605	COG1388	LysM domain
HW35_RS07605	COG0791	NLP P60 protein
HW35_RS07610	COG4750	Nucleotidyl transferase
HW35_RS07620	COG4750	Nucleotidyl transferase
HW35_RS07625	COG0697	spore germination
HW35_RS07645	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW35_RS07655	COG1876	peptidase activity
HW35_RS07660	COG3853	Toxic anion resistance protein (TelA)
HW35_RS07665	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HW35_RS07670	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HW35_RS07675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW35_RS07700	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW35_RS07705	COG0243	molybdopterin cofactor binding
HW35_RS07710	COG1301	dicarboxylic acid transport
HW35_RS07715	COG0737	Belongs to the 5'-nucleotidase family
HW35_RS07720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW35_RS07730	COG2252	PERMEase
HW35_RS07750	COG1522	sequence-specific DNA binding
HW35_RS07755	COG0436	Aminotransferase
HW35_RS07775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW35_RS07780	COG2971	BadF BadG BcrA BcrD
HW35_RS07805	COG4821	SIS domain
HW35_RS07905	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HW35_RS07910	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HW35_RS07915	COG1609	Transcriptional regulator
HW35_RS07930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW35_RS07940	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HW35_RS07950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_RS07955	COG0110	maltose O-acetyltransferase activity
HW35_RS07975	COG0778	Nitroreductase
HW35_RS07995	COG2822	iron ion transport
HW35_RS08000	COG2837	iron assimilation
HW35_RS08005	COG0672	)-iron permease
HW35_RS08030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW35_RS08055	COG1131	(ABC) transporter
HW35_RS08075	COG3037	sugar-specific permease SgaT UlaA
HW35_RS08085	COG3711	transcriptional antiterminator
HW35_RS08100	COG1136	(ABC) transporter
HW35_RS08130	COG1556	Lactate utilization protein
HW35_RS08135	COG1139	Iron-sulfur cluster binding protein
HW35_RS08140	COG0247	lactate metabolic process
HW35_RS08145	COG2186	Transcriptional regulator
HW35_RS08150	COG1620	l-lactate permease
HW35_RS08155	COG0277	FAD linked oxidase domain protein
HW35_RS08160	COG0247	lactate metabolic process
HW35_RS08170	COG1404	Belongs to the peptidase S8 family
HW35_RS08185	COG1191	sigma factor activity
HW35_RS08215	COG1482	cell wall glycoprotein biosynthetic process
HW35_RS08220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW35_RS08220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW35_RS08220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_RS08225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_RS08225	COG3711	transcriptional antiterminator
HW35_RS08230	COG1940	carbohydrate kinase activity
HW35_RS08245	COG2801	Transposase and inactivated derivatives
HW35_RS08275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW35_RS08285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW35_RS08305	COG0438	transferase activity, transferring glycosyl groups
HW35_RS08315	COG0587	DNA-directed DNA polymerase activity
HW35_RS08320	COG0438	transferase activity, transferring glycosyl groups
HW35_RS08330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW35_RS08335	COG4464	protein tyrosine phosphatase activity
HW35_RS08340	COG0489	protein tyrosine kinase activity
HW35_RS08345	COG3944	biosynthesis protein
HW35_RS08355	COG2801	Transposase and inactivated derivatives
HW35_RS08370	COG0791	NLP P60 protein
HW35_RS08370	COG1388	LysM domain
HW35_RS08385	COG0662	Cupin 2, conserved barrel domain protein
HW35_RS08390	COG4715	Zinc finger, swim domain protein
HW35_RS08395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW35_RS08405	COG1388	LysM domain
HW35_RS08405	COG3584	3D domain protein
HW35_RS08415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW35_RS08420	COG0765	amino acid transport
HW35_RS08425	COG1126	abc transporter atp-binding protein
HW35_RS08435	COG0629	single-stranded DNA binding
HW35_RS08465	COG1077	Cell shape determining protein MreB Mrl
HW35_RS08470	COG1609	Transcriptional regulator
HW35_RS08475	COG0768	penicillin binding
HW35_RS08485	COG0739	heme binding
HW35_RS08495	COG2385	sporulation resulting in formation of a cellular spore
HW35_RS08515	COG4836	Membrane
HW35_RS08520	COG1007	ATP synthesis coupled electron transport
HW35_RS08525	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW35_RS08530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW35_RS08540	COG0839	Belongs to the complex I subunit 6 family
HW35_RS08550	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HW35_RS08555	COG0649	NAD binding
HW35_RS08560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW35_RS08565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW35_RS08570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW35_RS08575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HW35_RS08580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HW35_RS08585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HW35_RS08590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HW35_RS08595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW35_RS08600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HW35_RS08605	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW35_RS08610	COG0356	it plays a direct role in the translocation of protons across the membrane
HW35_RS08630	COG1404	Belongs to the peptidase S8 family
HW35_RS08635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HW35_RS08650	COG0698	ribose 5-phosphate isomerase
HW35_RS08660	COG1971	Probably functions as a manganese efflux pump
HW35_RS08665	COG0009	L-threonylcarbamoyladenylate synthase
HW35_RS08680	COG2890	protein-(glutamine-N5) methyltransferase activity
HW35_RS08685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HW35_RS08695	COG1435	thymidine kinase activity
HW35_RS08705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HW35_RS08710	COG1494	fructose-1,6-bisphosphatase
HW35_RS08720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW35_RS08725	COG0191	fructose-bisphosphate aldolase activity
HW35_RS08730	COG2204	response regulator
HW35_RS08735	COG4821	SIS domain
HW35_RS08740	COG0504	CTP synthase activity
HW35_RS08745	COG3343	RNA polymerase activity
HW35_RS08755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_RS08755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_RS08755	COG1703	isobutyryl-CoA mutase activity
HW35_RS08765	COG1960	acyl-CoA dehydrogenase activity
HW35_RS08770	COG1960	acyl-CoA dehydrogenase activity
HW35_RS08775	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW35_RS08780	COG0183	Belongs to the thiolase family
HW35_RS08785	COG2181	nitrate reductase activity
HW35_RS08785	COG0247	lactate metabolic process
HW35_RS08790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW35_RS08795	COG3344	reverse transcriptase
HW35_RS08805	COG0018	arginyl-trna synthetase
HW35_RS08810	COG4506	Protein conserved in bacteria
HW35_RS08815	COG0010	Belongs to the arginase family
HW35_RS08820	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW35_RS08825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW35_RS08835	COG1994	Peptidase M50
HW35_RS08845	COG3465	dGTPase activity
HW35_RS08850	COG1078	dGTPase activity
HW35_RS08855	COG4844	belongs to the
HW35_RS08865	COG0095	Lipoate-protein ligase
HW35_RS08880	COG0280	phosphate acetyltransferase
HW35_RS08885	COG3253	May function as heme-dependent peroxidase
HW35_RS08895	COG2363	Small membrane protein
HW35_RS08905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW35_RS08915	COG0314	molybdopterin synthase activity
HW35_RS08925	COG0351	phosphomethylpyrimidine kinase
HW35_RS08930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW35_RS08940	COG1113	amino acid transport
HW35_RS08970	COG1131	(ABC) transporter
HW35_RS08980	COG0561	phosphatase activity
HW35_RS09020	COG0477	Major facilitator Superfamily
HW35_RS09025	COG1132	(ABC) transporter
HW35_RS09030	COG1132	(ABC) transporter
HW35_RS09040	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW35_RS09045	COG0069	glutamate synthase activity
HW35_RS09050	COG0583	DNA-binding transcription factor activity
HW35_RS09055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW35_RS09085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HW35_RS09125	COG4499	WXG100 protein secretion system (Wss), protein YukC
HW35_RS09125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW35_RS09165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW35_RS09170	COG1122	ATPase activity
HW35_RS09180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HW35_RS09195	COG0183	Belongs to the thiolase family
HW35_RS09200	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_RS09205	COG1268	BioY protein
HW35_RS09210	COG3344	reverse transcriptase
HW35_RS09215	COG0655	NAD(P)H dehydrogenase (quinone) activity
HW35_RS09230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HW35_RS09240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW35_RS09245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW35_RS09250	COG4853	Protein conserved in bacteria
HW35_RS09255	COG4863	YycH protein
HW35_RS09260	COG5002	protein histidine kinase activity
HW35_RS09265	COG0745	RESPONSE REGULATOR receiver
HW35_RS09270	COG0739	heme binding
HW35_RS09270	COG1196	nuclear chromosome segregation
HW35_RS09270	COG0741	lytic transglycosylase activity
HW35_RS09305	COG0305	Participates in initiation and elongation during chromosome replication
HW35_RS09315	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HW35_RS09330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW35_RS09335	COG0629	single-stranded DNA binding
HW35_RS09340	COG0360	Binds together with S18 to 16S ribosomal RNA
HW35_RS09345	COG0012	GTP binding
HW35_RS09350	COG0243	molybdopterin cofactor binding
HW35_RS09355	COG4481	Protein conserved in bacteria
HW35_RS09360	COG0668	transmembrane transport
HW35_RS09375	COG1475	DNA binding
HW35_RS09380	COG1192	Involved in chromosome partitioning
HW35_RS09385	COG1475	DNA binding
HW35_RS09390	COG0357	Ribosomal RNA small subunit methyltransferase G
HW35_RS09400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HW35_RS09405	COG1847	R3H domain protein
HW35_RS09415	COG0594	ribonuclease P activity
HW35_RS09425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW35_RS09430	COG0592	DNA-directed DNA polymerase activity
HW35_RS09435	COG2501	S4 domain
HW35_RS09440	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW35_RS09450	COG0187	DNA topoisomerase II activity
HW35_RS09455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW35_RS09495	COG0517	IMP dehydrogenase activity
HW35_RS09495	COG0516	GMP reductase activity
HW35_RS09510	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HW35_RS09525	COG1428	Deoxynucleoside kinase
HW35_RS09530	COG1428	Deoxynucleoside kinase
HW35_RS09535	COG3858	chitin binding
HW35_RS09535	COG1388	LysM domain
HW35_RS09540	COG0590	tRNA wobble adenosine to inosine editing
HW35_RS09545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW35_RS09555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HW35_RS09600	COG1982	Orn Lys Arg decarboxylase major
HW35_RS09605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW35_RS09610	COG3870	Protein conserved in bacteria
HW35_RS09615	COG0470	DNA polymerase III
HW35_RS09620	COG1774	PSP1 C-terminal conserved region
HW35_RS09625	COG4467	Involved in initiation control of chromosome replication
HW35_RS09630	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HW35_RS09635	COG2827	Endonuclease containing a URI domain
HW35_RS09640	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HW35_RS09645	COG2002	toxin-antitoxin pair type II binding
HW35_RS09660	COG0084	hydrolase, TatD family'
HW35_RS09665	COG3583	domain protein
HW35_RS09665	COG3584	3D domain protein
HW35_RS09675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW35_RS09685	COG4466	Protein conserved in bacteria
HW35_RS09700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW35_RS09705	COG0251	oxidation-reduction process
HW35_RS09710	COG2088	sporulation resulting in formation of a cellular spore
HW35_RS09715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW35_RS09725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HW35_RS09740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW35_RS09745	COG2002	toxin-antitoxin pair type II binding
HW35_RS09750	COG2244	polysaccharide biosynthetic process
HW35_RS09755	COG3956	TIGRFAM MazG family protein
HW35_RS09760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW35_RS09780	COG1098	S1 RNA binding domain
HW35_RS09790	COG2208	phosphoserine phosphatase activity
HW35_RS09795	COG2304	oxidoreductase activity
HW35_RS09800	COG0515	serine threonine protein kinase
HW35_RS09810	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HW35_RS09815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW35_RS09820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HW35_RS09825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HW35_RS09830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW35_RS09835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW35_RS09840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW35_RS09845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW35_RS09850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HW35_RS09855	COG1396	sequence-specific DNA binding
HW35_RS09860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW35_RS09870	COG3226	Transcriptional regulator
HW35_RS10020	COG3880	PFAM UvrB UvrC protein
HW35_RS10025	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HW35_RS10030	COG0542	response to heat
HW35_RS10035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HW35_RS10040	COG4956	integral membrane protein (PIN domain superfamily)
HW35_RS10045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HW35_RS10050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HW35_RS10055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW35_RS10060	COG1045	serine acetyltransferase
HW35_RS10065	COG0215	cysteine-tRNA ligase activity
HW35_RS10075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW35_RS10080	COG3688	RNA-binding protein containing a PIN domain
HW35_RS10090	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW35_RS10095	COG0250	Participates in transcription elongation, termination and antitermination
HW35_RS10100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HW35_RS10105	COG0081	regulation of translation
HW35_RS10110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW35_RS10115	COG0222	ribosome binding
HW35_RS10120	COG2813	Specifically methylates the guanine in position
HW35_RS10125	COG0085	RNA polymerase activity
HW35_RS10135	COG1358	cellular component organization or biogenesis
HW35_RS10140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HW35_RS10145	COG0049	tRNA binding
HW35_RS10150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HW35_RS10155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW35_RS10165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HW35_RS10170	COG0088	Forms part of the polypeptide exit tunnel
HW35_RS10185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW35_RS10195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HW35_RS10200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW35_RS10215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HW35_RS10220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HW35_RS10225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HW35_RS10230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW35_RS10240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HW35_RS10245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HW35_RS10250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW35_RS10255	COG1841	ribosomal large subunit assembly
HW35_RS10260	COG0200	Binds to the 23S rRNA
HW35_RS10265	COG0201	protein transport
HW35_RS10270	COG0563	adenylate kinase activity
HW35_RS10275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW35_RS10280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW35_RS10285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HW35_RS10290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HW35_RS10295	COG0202	RNA polymerase activity
HW35_RS10300	COG0203	ribosomal protein L17
HW35_RS10305	COG1122	ATPase activity
HW35_RS10310	COG1122	ATPase activity
HW35_RS10315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW35_RS10320	COG0101	tRNA pseudouridine synthase activity
HW35_RS10325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW35_RS10330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HW35_RS10375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW35_RS10380	COG1136	(ABC) transporter
HW35_RS10385	COG0577	efflux transmembrane transporter activity
HW35_RS10390	COG1757	Na H antiporter
HW35_RS10415	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW35_RS10420	COG0489	protein tyrosine kinase activity
HW35_RS10430	COG2194	sulfuric ester hydrolase activity
HW35_RS10435	COG0726	polysaccharide deacetylase
HW35_RS10515	COG1595	DNA-templated transcription, initiation
HW35_RS10520	COG5662	AntiSigma factor
HW35_RS10525	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HW35_RS10530	COG4856	YbbR-like protein
HW35_RS10535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW35_RS10540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW35_RS10565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW35_RS10575	COG1388	LysM domain
HW35_RS10590	COG0398	Pfam SNARE associated Golgi protein
HW35_RS10595	COG0745	RESPONSE REGULATOR receiver
HW35_RS10600	COG5002	protein histidine kinase activity
HW35_RS10615	COG3711	transcriptional antiterminator
HW35_RS10615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_RS10620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW35_RS10625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW35_RS10630	COG1447	Phosphotransferase system cellobiose-specific component IIA
HW35_RS10635	COG2723	6-phospho-beta-galactosidase activity
HW35_RS10660	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HW35_RS10665	COG1846	Transcriptional regulator
HW35_RS10690	COG3711	transcriptional antiterminator
HW35_RS10710	COG3655	Transcriptional regulator
HW35_RS10730	COG0693	protein deglycase activity
HW35_RS10735	COG2409	Drug exporters of the RND superfamily
HW35_RS10760	COG1309	transcriptional regulator
HW35_RS10770	COG0018	arginyl-trna synthetase
HW35_RS10780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW35_RS10785	COG2076	Multidrug Resistance protein
HW35_RS10790	COG2076	Multidrug Resistance protein
HW35_RS10795	COG0586	Pfam SNARE associated Golgi protein
HW35_RS10800	COG0772	Belongs to the SEDS family
HW35_RS10805	COG2239	Acts as a magnesium transporter
HW35_RS10815	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW35_RS10820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW35_RS10835	COG0705	Rhomboid family
HW35_RS10840	COG0736	holo-[acyl-carrier-protein] synthase activity
HW35_RS10845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HW35_RS10855	COG0864	Transcriptional regulator
HW35_RS10860	COG2337	Toxic component of a toxin-antitoxin (TA) module
HW35_RS10875	COG2183	response to ionizing radiation
HW35_RS10880	COG3091	SprT-like family
HW35_RS10960	COG0802	atpase or kinase
HW35_RS10965	COG1214	PFAM Peptidase M22, glycoprotease
HW35_RS10970	COG0456	acetyltransferase
HW35_RS10980	COG0488	(ABC) transporter
HW35_RS10990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HW35_RS11000	COG1266	CAAX protease self-immunity
HW35_RS11005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW35_RS11010	COG0459	protein refolding
HW35_RS11015	COG1940	carbohydrate kinase activity
HW35_RS11025	COG2814	Major facilitator Superfamily
HW35_RS11025	COG0477	Major facilitator Superfamily
HW35_RS11030	COG1070	Carbohydrate kinase
HW35_RS11050	COG0730	response to heat
HW35_RS11055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HW35_RS11055	COG0519	Catalyzes the synthesis of GMP from XMP
HW35_RS11060	COG2252	PERMEase
HW35_RS11065	COG3711	transcriptional antiterminator
HW35_RS11070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW35_RS11070	COG1263	PTS System
HW35_RS11070	COG2190	(PTS) system
HW35_RS11105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HW35_RS11110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HW35_RS11115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW35_RS11120	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HW35_RS11125	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW35_RS11130	COG0047	phosphoribosylformylglycinamidine synthase activity
HW35_RS11135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW35_RS11140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HW35_RS11145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HW35_RS11150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW35_RS11155	COG0138	bifunctional purine biosynthesis protein purh
HW35_RS11160	COG0151	Belongs to the GarS family
HW35_RS11175	COG1470	cell adhesion involved in biofilm formation
HW35_RS11180	COG4496	protein, YerC YecD
HW35_RS11185	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HW35_RS11190	COG0210	DNA helicase
HW35_RS11195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HW35_RS11200	COG4851	CamS sex pheromone cAM373 precursor
HW35_RS11205	COG1012	belongs to the aldehyde dehydrogenase family
HW35_RS11210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW35_RS11215	COG2146	nitrite reductase [NAD(P)H] activity
HW35_RS11230	COG2224	Isocitrate lyase
HW35_RS11235	COG1764	response to oxidative stress
HW35_RS11245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW35_RS11250	COG0154	amidase activity
HW35_RS11255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW35_RS11260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW35_RS11265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HW35_RS11270	COG1597	lipid kinase activity
HW35_RS11275	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HW35_RS11335	COG0109	protoheme IX farnesyltransferase activity
HW35_RS11345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW35_RS11350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW35_RS11365	COG1253	flavin adenine dinucleotide binding
HW35_RS11370	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HW35_RS11370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW35_RS11380	COG1263	PTS System
HW35_RS11380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW35_RS11385	COG3711	transcriptional antiterminator
HW35_RS11400	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_RS11405	COG4605	iron ion homeostasis
HW35_RS11410	COG4604	ABC transporter, ATP-binding protein
HW35_RS11415	COG4607	ABC-type enterochelin transport system periplasmic component
HW35_RS11420	COG2329	Antibiotic biosynthesis monooxygenase
HW35_RS11425	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HW35_RS11430	COG1268	BioY protein
HW35_RS11435	COG1115	amino acid carrier protein
HW35_RS11450	COG0346	lactoylglutathione lyase activity
HW35_RS11455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HW35_RS11460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW35_RS11465	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HW35_RS11470	COG2017	converts alpha-aldose to the beta-anomer
HW35_RS11475	COG1609	Transcriptional regulator
HW35_RS11485	COG2972	Histidine kinase
HW35_RS11490	COG2201	protein-glutamate methylesterase activity
HW35_RS11500	COG1129	ABC transporter
HW35_RS11505	COG4211	Belongs to the binding-protein-dependent transport system permease family
HW35_RS11510	COG1725	Transcriptional regulator
HW35_RS11515	COG1131	(ABC) transporter
HW35_RS11525	COG1595	DNA-templated transcription, initiation
HW35_RS11540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW35_RS11560	COG1620	l-lactate permease
HW35_RS11570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW35_RS11595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW35_RS11600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_RS11605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_RS11610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW35_RS11615	COG1120	ATPase activity
HW35_RS11620	COG0492	ferredoxin-NADP+ reductase activity
HW35_RS11625	COG2318	DinB family
HW35_RS11630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW35_RS11635	COG3344	reverse transcriptase
HW35_RS11650	COG1136	(ABC) transporter
HW35_RS11655	COG0642	Histidine kinase
HW35_RS11660	COG0745	RESPONSE REGULATOR receiver
HW35_RS11665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW35_RS11670	COG1823	symporter activity
HW35_RS11675	COG0494	nUDIX hydrolase
HW35_RS11690	COG0673	inositol 2-dehydrogenase activity
HW35_RS11705	COG0194	GDP metabolic process
HW35_RS11725	COG2205	protein histidine kinase activity
HW35_RS11735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HW35_RS11740	COG0583	DNA-binding transcription factor activity
HW35_RS11755	COG3250	beta-galactosidase activity
HW35_RS11770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW35_RS11775	COG0765	amino acid transport
HW35_RS11780	COG0765	amino acid transport
HW35_RS11785	COG2801	Transposase and inactivated derivatives
HW35_RS11800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW35_RS11805	COG2022	thiamine diphosphate biosynthetic process
HW35_RS11815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW35_RS11820	COG0352	thiamine-phosphate diphosphorylase activity
HW35_RS11840	COG1136	(ABC) transporter
HW35_RS11840	COG0577	efflux transmembrane transporter activity
HW35_RS11850	COG3584	3D domain protein
HW35_RS11850	COG1388	LysM domain
HW35_RS11860	COG0475	glutathione-regulated potassium exporter activity
HW35_RS11880	COG0673	inositol 2-dehydrogenase activity
HW35_RS11885	COG1129	ABC transporter
HW35_RS11890	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW35_RS11895	COG1879	ABC-type sugar transport system periplasmic component
HW35_RS11900	COG1609	Transcriptional regulator
HW35_RS11905	COG0673	inositol 2-dehydrogenase activity
HW35_RS11920	COG3962	Belongs to the TPP enzyme family
HW35_RS11925	COG1082	Xylose isomerase domain protein TIM barrel
HW35_RS11930	COG0191	fructose-bisphosphate aldolase activity
HW35_RS11935	COG3718	enzyme involved in inositol metabolism
HW35_RS11945	COG0494	nUDIX hydrolase
HW35_RS11955	COG0500	methyltransferase
HW35_RS11960	COG1073	alpha beta
HW35_RS11970	COG1609	Transcriptional regulator
HW35_RS11980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW35_RS11995	COG4145	pantothenate transmembrane transporter activity
HW35_RS12000	COG0517	IMP dehydrogenase activity
HW35_RS12005	COG2340	Cysteine-rich secretory protein family
HW35_RS12020	COG2807	transmembrane transport
HW35_RS12045	COG3844	kynureninase activity
HW35_RS12060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW35_RS12070	COG1136	(ABC) transporter
HW35_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_RS12095	COG1169	isochorismate synthase
HW35_RS12100	COG1535	isochorismatase
HW35_RS12100	COG3433	isochorismatase activity
HW35_RS12105	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HW35_RS12105	COG1605	Chorismate mutase
HW35_RS12110	COG1021	2,3-dihydroxybenzoate-AMP ligase
HW35_RS12115	COG3433	isochorismatase activity
HW35_RS12115	COG1535	isochorismatase
HW35_RS12120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW35_RS12175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW35_RS12175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW35_RS12180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW35_RS12180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW35_RS12195	COG2258	MOSC domain
HW35_RS12220	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HW35_RS12235	COG0716	FMN binding
HW35_RS12245	COG0432	Pfam Uncharacterised protein family UPF0047
HW35_RS12260	COG0733	neurotransmitter:sodium symporter activity
HW35_RS12265	COG1051	belongs to the nudix hydrolase family
HW35_RS12270	COG2814	Major facilitator Superfamily
HW35_RS12295	COG2832	Protein of unknown function (DUF454)
HW35_RS12315	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HW35_RS12320	COG3483	tryptophan 2,3-dioxygenase activity
HW35_RS12325	COG1113	amino acid transport
HW35_RS12330	COG1309	transcriptional regulator
HW35_RS12345	COG2368	4-hydroxyphenylacetate
HW35_RS12350	COG0431	NADPH-dependent FMN reductase
HW35_RS12365	COG0251	oxidation-reduction process
HW35_RS12375	COG3971	2-oxopent-4-enoate hydratase activity
HW35_RS12395	COG1027	Aspartate ammonia-lyase
HW35_RS12400	COG0582	viral genome integration into host DNA
HW35_RS12405	COG0490	domain, Protein
HW35_RS12410	COG0475	glutathione-regulated potassium exporter activity
HW35_RS12415	COG1414	Transcriptional regulator
HW35_RS12440	COG2176	DNA-directed DNA polymerase activity
HW35_RS12460	COG2346	COG2346, Truncated hemoglobins
HW35_RS12465	COG1653	transport
HW35_RS12480	COG1609	Transcriptional regulator
HW35_RS12490	COG0673	inositol 2-dehydrogenase activity
HW35_RS12495	COG0673	inositol 2-dehydrogenase activity
HW35_RS12510	COG0366	Alpha amylase catalytic
HW35_RS12525	COG0697	spore germination
HW35_RS12530	COG3832	glyoxalase III activity
HW35_RS12550	COG0166	Belongs to the GPI family
HW35_RS12555	COG3189	MarR family transcriptional regulator
HW35_RS12560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_RS12565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_RS12570	COG3414	Phosphotransferase system galactitol-specific IIB component
HW35_RS12575	COG3775	system Galactitol-specific IIC component
HW35_RS12580	COG1063	alcohol dehydrogenase
HW35_RS12595	COG0456	acetyltransferase
HW35_RS12605	COG2801	Transposase and inactivated derivatives
HW35_RS12610	COG0066	3-isopropylmalate dehydratase activity
HW35_RS12615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HW35_RS12620	COG0473	3-isopropylmalate dehydrogenase activity
HW35_RS12625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW35_RS12630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HW35_RS12635	COG0440	acetolactate synthase activity
HW35_RS12640	COG0028	Belongs to the TPP enzyme family
HW35_RS12645	COG0129	dihydroxy-acid dehydratase activity
HW35_RS12655	COG0004	ammonium transporteR
HW35_RS12660	COG0789	Transcriptional regulator
HW35_RS12675	COG0765	amino acid transport
HW35_RS12680	COG1126	abc transporter atp-binding protein
HW35_RS12695	COG0183	Belongs to the thiolase family
HW35_RS12705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW35_RS12710	COG0514	ATP-dependent DNA helicase (RecQ)
HW35_RS12715	COG0535	radical SAM domain protein
HW35_RS12720	COG2814	Major facilitator Superfamily
HW35_RS12730	COG1129	ABC transporter
HW35_RS12735	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW35_RS12745	COG1966	Carbon starvation protein
HW35_RS12750	COG2966	Psort location CytoplasmicMembrane, score
HW35_RS12760	COG3275	phosphorelay sensor kinase activity
HW35_RS12770	COG1966	Carbon starvation protein
HW35_RS12775	COG0531	amino acid
HW35_RS12780	COG2801	Transposase and inactivated derivatives
HW35_RS12790	COG5002	protein histidine kinase activity
HW35_RS12795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HW35_RS12795	COG2199	diguanylate cyclase activity
HW35_RS12810	COG0243	molybdopterin cofactor binding
HW35_RS12840	COG4585	Histidine kinase
HW35_RS12845	COG2197	response regulator
HW35_RS12870	COG1114	Component of the transport system for branched-chain amino acids
HW35_RS12900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW35_RS12910	COG0723	plastoquinol--plastocyanin reductase activity
HW35_RS12910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW35_RS12940	COG2197	response regulator
HW35_RS12945	COG2244	polysaccharide biosynthetic process
HW35_RS12950	COG2801	Transposase and inactivated derivatives
HW35_RS12955	COG0670	Belongs to the BI1 family
HW35_RS12960	COG1970	mechanosensitive ion channel activity
HW35_RS12965	COG2309	aminopeptidase activity
HW35_RS12975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW35_RS12975	COG0551	DNA topoisomerase type I activity
HW35_RS12980	COG2986	histidine ammonia-lyase
HW35_RS13000	COG0024	Methionine aminopeptidase
HW35_RS13005	COG4840	Belongs to the UPF0435 family
HW35_RS13010	COG4980	gas vesicle protein
HW35_RS13015	COG1295	ribonuclease BN
HW35_RS13020	COG2801	Transposase and inactivated derivatives
HW35_RS13030	COG2217	Heavy metal translocating P-type atpase
HW35_RS13035	COG0477	Major facilitator Superfamily
HW35_RS13040	COG0387	Pfam Sodium calcium exchanger
HW35_RS13070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW35_RS13100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW35_RS13105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW35_RS13110	COG0640	Transcriptional regulator
HW35_RS13120	COG1695	Transcriptional regulator
HW35_RS13135	COG1695	Transcriptional regulator
HW35_RS13150	COG3708	Transcriptional regulator
HW35_RS13150	COG2207	Transcriptional regulator
HW35_RS13160	COG1929	Belongs to the glycerate kinase type-1 family
HW35_RS13175	COG0039	L-malate dehydrogenase activity
HW35_RS13180	COG1620	l-lactate permease
HW35_RS13185	COG0456	acetyltransferase
HW35_RS13185	COG1846	Transcriptional regulator
HW35_RS13195	COG1533	DNA photolyase activity
HW35_RS13210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW35_RS13215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW35_RS13220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HW35_RS13230	COG1960	acyl-CoA dehydrogenase activity
HW35_RS13235	COG0784	Response regulator, receiver
HW35_RS13240	COG4191	Histidine kinase
HW35_RS13255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW35_RS13260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW35_RS13265	COG0438	transferase activity, transferring glycosyl groups
HW35_RS13275	COG0438	transferase activity, transferring glycosyl groups
HW35_RS13280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW35_RS13310	COG1518	maintenance of DNA repeat elements
HW35_RS13315	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HW35_RS13330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW35_RS13340	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HW35_RS13345	COG1140	nitrate reductase beta subunit
HW35_RS13350	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HW35_RS13355	COG2181	nitrate reductase activity
HW35_RS13365	COG2066	Belongs to the glutaminase family
HW35_RS13370	COG3104	oligopeptide transport
HW35_RS13375	COG0789	Transcriptional regulator
HW35_RS13380	COG0444	Belongs to the ABC transporter superfamily
HW35_RS13385	COG4608	Belongs to the ABC transporter superfamily
HW35_RS13390	COG0747	negative chemotaxis
HW35_RS13395	COG0601	transmembrane transport
HW35_RS13400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW35_RS13405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW35_RS13410	COG0710	3-dehydroquinate dehydratase activity
HW35_RS13415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HW35_RS13420	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HW35_RS13425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HW35_RS13430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW35_RS13435	COG0505	Belongs to the CarA family
HW35_RS13440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HW35_RS13445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW35_RS13450	COG0137	argininosuccinate synthase activity
HW35_RS13455	COG0165	Argininosuccinate lyase
HW35_RS13460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW35_RS13460	COG3153	acetyltransferase
HW35_RS13465	COG0456	acetyltransferase
HW35_RS13470	COG0460	homoserine dehydrogenase
HW35_RS13480	COG2137	regulation of response to DNA damage stimulus
HW35_RS13490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW35_RS13500	COG0300	oxidoreductase activity
HW35_RS13520	COG1988	membrane-bound metal-dependent
HW35_RS13525	COG1194	a g-specific adenine glycosylase
HW35_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_RS13555	COG1132	(ABC) transporter
HW35_RS13560	COG4129	membrane
HW35_RS13565	COG0067	glutamate synthase
HW35_RS13565	COG0069	glutamate synthase activity
HW35_RS13565	COG0070	glutamate synthase
HW35_RS13570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW35_RS13575	COG4555	ABC transporter
HW35_RS13595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW35_RS13600	COG2096	Adenosyltransferase
HW35_RS13605	COG0735	belongs to the Fur family
HW35_RS13705	COG4974	Belongs to the 'phage' integrase family
HW35_RS13720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW35_RS13735	COG1674	ftsk spoiiie
HW35_RS13805	COG1797	cobyrinic acid a,c-diamide synthase activity
HW35_RS13810	COG0071	Belongs to the small heat shock protein (HSP20) family
HW35_RS13835	COG3382	B3 4 domain protein
HW35_RS13840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HW35_RS13845	COG2801	Transposase and inactivated derivatives
HW35_RS13870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW35_RS13875	COG2766	serine protein kinase
HW35_RS13880	COG2718	Belongs to the UPF0229 family
HW35_RS13885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW35_RS13885	COG2190	(PTS) system
HW35_RS13885	COG1263	PTS System
HW35_RS13890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW35_RS13895	COG0363	glucosamine-6-phosphate deaminase activity
HW35_RS13900	COG2188	Transcriptional regulator
HW35_RS13905	COG2340	Cysteine-rich secretory protein family
HW35_RS13910	COG3344	reverse transcriptase
HW35_RS13920	COG5002	protein histidine kinase activity
HW35_RS13925	COG0737	Belongs to the 5'-nucleotidase family
HW35_RS13930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HW35_RS13935	COG0306	phosphate transporter
HW35_RS13940	COG1392	Phosphate transport regulator
HW35_RS13945	COG2261	transglycosylase associated protein
HW35_RS13950	COG0564	pseudouridine synthase activity
HW35_RS13960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW35_RS13970	COG2866	Carboxypeptidase
HW35_RS13980	COG2719	SpoVR family
HW35_RS13985	COG0686	Belongs to the AlaDH PNT family
HW35_RS13990	COG2508	Transcriptional regulator
HW35_RS13990	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HW35_RS14000	COG3344	reverse transcriptase
HW35_RS14005	COG2733	membrane
HW35_RS14010	COG4841	protein insertion into membrane
HW35_RS14035	COG1253	flavin adenine dinucleotide binding
HW35_RS14040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW35_RS14045	COG3852	Histidine kinase
HW35_RS14050	COG3859	Proton-coupled thiamine transporter YuaJ
HW35_RS14070	COG3842	ATPase activity
HW35_RS14075	COG2508	Transcriptional regulator
HW35_RS14095	COG0189	ligase activity
HW35_RS14100	COG0189	ligase activity
HW35_RS14105	COG0189	ligase activity
HW35_RS14110	COG3679	Belongs to the UPF0342 family
HW35_RS14115	COG0561	phosphatase activity
HW35_RS14120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW35_RS14125	COG1024	Enoyl-CoA hydratase
HW35_RS14135	COG4152	abc transporter atp-binding protein
HW35_RS14140	COG1668	transmembrane transport
HW35_RS14145	COG0420	3'-5' exonuclease activity
HW35_RS14150	COG4717	serine-type aminopeptidase activity
HW35_RS14155	COG3481	metal-dependent phosphohydrolase, HD sub domain
HW35_RS14165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW35_RS14185	COG1846	Transcriptional regulator
HW35_RS14200	COG0537	adenosine 5'-monophosphoramidase activity
HW35_RS14205	COG1131	(ABC) transporter
HW35_RS14210	COG4473	ABC transporter
HW35_RS14225	COG3069	C4-dicarboxylate transmembrane transporter activity
HW35_RS14230	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HW35_RS14235	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HW35_RS14240	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HW35_RS14245	COG1511	domain protein
HW35_RS14250	COG1234	tRNA 3'-trailer cleavage
HW35_RS14255	COG0095	Lipoate-protein ligase
HW35_RS14260	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_RS14265	COG1024	Enoyl-CoA hydratase
HW35_RS14270	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HW35_RS14280	COG0501	Belongs to the peptidase M48B family
HW35_RS14305	COG0398	Pfam SNARE associated Golgi protein
HW35_RS14315	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HW35_RS14320	COG1074	ATP-dependent DNA helicase activity
HW35_RS14365	COG0367	asparagine synthase
HW35_RS14375	COG1666	GTP binding
HW35_RS14380	COG2996	Protein conserved in bacteria
HW35_RS14385	COG3344	reverse transcriptase
HW35_RS14390	COG1307	EDD domain protein, DegV family
HW35_RS14415	COG0561	phosphatase activity
HW35_RS14420	COG2151	metal-sulfur cluster biosynthetic enzyme
HW35_RS14430	COG0535	radical SAM domain protein
HW35_RS14435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW35_RS14440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HW35_RS14445	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HW35_RS14450	COG0303	'Molybdopterin
HW35_RS14455	COG1763	Mo-molybdopterin cofactor biosynthetic process
HW35_RS14465	COG0542	response to heat
HW35_RS14475	COG2267	carboxylic ester hydrolase activity
HW35_RS14485	COG1744	ABC transporter substrate-binding protein PnrA-like
HW35_RS14490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW35_RS14495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW35_RS14500	COG5504	Zn-dependent protease
HW35_RS14505	COG0444	Belongs to the ABC transporter superfamily
HW35_RS14510	COG4608	Belongs to the ABC transporter superfamily
HW35_RS14520	COG0601	transmembrane transport
HW35_RS14525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW35_RS14535	COG0180	Tryptophanyl-tRNA synthetase
HW35_RS14550	COG0601	transmembrane transport
HW35_RS14555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW35_RS14560	COG0444	Belongs to the ABC transporter superfamily
HW35_RS14565	COG4608	Belongs to the ABC transporter superfamily
HW35_RS14575	COG1393	Belongs to the ArsC family
HW35_RS14585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW35_RS14595	COG1164	Oligoendopeptidase f
HW35_RS14605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HW35_RS14610	COG2346	COG2346, Truncated hemoglobins
HW35_RS14615	COG4116	CYTH
HW35_RS14625	COG2357	RelA SpoT domain protein
HW35_RS14635	COG0564	pseudouridine synthase activity
HW35_RS14640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HW35_RS14645	COG0569	domain protein
HW35_RS14645	COG0475	glutathione-regulated potassium exporter activity
HW35_RS14650	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HW35_RS14685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW35_RS14700	COG2153	protein acetylation
HW35_RS14705	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HW35_RS14710	COG2382	esterase
HW35_RS14750	COG2801	Transposase and inactivated derivatives
HW35_RS14760	COG0725	ABC transporter, periplasmic molybdate-binding protein
HW35_RS14775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW35_RS14780	COG1136	(ABC) transporter
HW35_RS14785	COG0577	efflux transmembrane transporter activity
HW35_RS14790	COG3344	reverse transcriptase
HW35_RS14800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW35_RS14805	COG0512	Glutamine amidotransferase of anthranilate synthase
HW35_RS14810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW35_RS14820	COG0436	Aminotransferase
HW35_RS14830	COG1968	undecaprenyl-diphosphatase activity
HW35_RS14835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW35_RS14845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HW35_RS14850	COG1191	sigma factor activity
HW35_RS14875	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HW35_RS14880	COG0674	pyruvate-flavodoxin oxidoreductase activity
HW35_RS14885	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HW35_RS14890	COG0436	Aminotransferase
HW35_RS14895	COG1850	ribulose-bisphosphate carboxylase activity
HW35_RS14900	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HW35_RS14905	COG0235	Class ii aldolase
HW35_RS14910	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HW35_RS14920	COG0644	oxidoreductase
HW35_RS14930	COG0204	Acyl-transferase
HW35_RS14935	COG3949	Membrane
HW35_RS14940	COG0542	response to heat
HW35_RS14955	COG1846	Transcriptional regulator
HW35_RS14960	COG3852	Histidine kinase
HW35_RS14965	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HW35_RS14980	COG4873	Protein conserved in bacteria
HW35_RS14990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW35_RS15000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW35_RS15005	COG2084	Dehydrogenase
HW35_RS15020	COG2801	Transposase and inactivated derivatives
HW35_RS15025	COG0436	Aminotransferase
HW35_RS15035	COG5001	Diguanylate cyclase
HW35_RS15035	COG3300	MHYT domain
HW35_RS15045	COG3344	reverse transcriptase
HW35_RS15065	COG1408	metallophosphoesterase
HW35_RS15070	COG2200	EAL domain
HW35_RS15080	COG4703	Protein of unknown function (DUF1797)
HW35_RS15085	COG0517	IMP dehydrogenase activity
HW35_RS15090	COG0477	Major facilitator Superfamily
HW35_RS15095	COG0583	DNA-binding transcription factor activity
HW35_RS15100	COG2171	N-acyltransferase activity
HW35_RS15105	COG1473	amidohydrolase
HW35_RS15110	COG0569	domain protein
HW35_RS15115	COG2801	Transposase and inactivated derivatives
HW35_RS15120	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW35_RS15125	COG5503	Protein of unknown function (DUF1447)
HW35_RS15145	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW35_RS15170	COG1982	Orn Lys Arg decarboxylase major
HW35_RS15180	COG4476	Belongs to the UPF0223 family
HW35_RS15195	COG4493	Belongs to the UPF0637 family
HW35_RS15205	COG0483	inositol monophosphate 1-phosphatase activity
HW35_RS15215	COG1217	gtp-binding protein TYPA
HW35_RS15230	COG4896	Protein conserved in bacteria
HW35_RS15245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HW35_RS15250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW35_RS15260	COG0772	Belongs to the SEDS family
HW35_RS15265	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW35_RS15275	COG2801	Transposase and inactivated derivatives
HW35_RS15280	COG1612	heme a metabolic process
HW35_RS15285	COG0109	protoheme IX farnesyltransferase activity
HW35_RS15310	COG3336	cytochrome c oxidase
HW35_RS15325	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HW35_RS15330	COG2340	Cysteine-rich secretory protein family
HW35_RS15360	COG3679	Belongs to the UPF0342 family
HW35_RS15365	COG4471	UPF0298 protein
HW35_RS15375	COG2801	Transposase and inactivated derivatives
HW35_RS15380	COG0742	ribosomal rna small subunit methyltransferase
HW35_RS15385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HW35_RS15400	COG3314	Sporulation integral membrane protein YlbJ
HW35_RS15405	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW35_RS15410	COG3480	Lon protease (S16) C-terminal proteolytic domain
HW35_RS15415	COG1323	Belongs to the UPF0348 family
HW35_RS15420	COG1399	metal-binding, possibly nucleic acid-binding protein
HW35_RS15425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HW35_RS15430	COG1024	Enoyl-CoA hydratase
HW35_RS15440	COG0454	-acetyltransferase
HW35_RS15445	COG0439	Biotin carboxylase
HW35_RS15450	COG0511	ligase activity, forming carbon-carbon bonds
HW35_RS15455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW35_RS15460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW35_RS15470	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HW35_RS15475	COG2001	Belongs to the MraZ family
HW35_RS15485	COG4839	cell division protein FtsL
HW35_RS15490	COG0768	penicillin binding
HW35_RS15495	COG0768	penicillin binding
HW35_RS15500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW35_RS15510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW35_RS15515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW35_RS15520	COG0772	Belongs to the SEDS family
HW35_RS15530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HW35_RS15535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HW35_RS15540	COG3879	Bacterial protein of unknown function (DUF881)
HW35_RS15545	COG3879	Bacterial protein of unknown function (DUF881)
HW35_RS15550	COG3856	small basic protein
HW35_RS15555	COG0849	cell division
HW35_RS15560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW35_RS15565	COG3344	reverse transcriptase
HW35_RS15575	COG1191	sigma factor activity
HW35_RS15585	COG1191	sigma factor activity
HW35_RS15590	COG1873	PFAM PRC-barrel domain
HW35_RS15600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW35_RS15605	COG1799	cell septum assembly
HW35_RS15610	COG0762	integral membrane protein
HW35_RS15615	COG2302	S4 RNA-binding domain
HW35_RS15620	COG3599	regulation of cell shape
HW35_RS15625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HW35_RS15635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HW35_RS15640	COG0564	pseudouridine synthase activity
HW35_RS15645	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HW35_RS15655	COG0540	Belongs to the ATCase OTCase family
HW35_RS15670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HW35_RS15680	COG0167	dihydroorotate dehydrogenase activity
HW35_RS15685	COG0284	orotidine-5'-phosphate decarboxylase activity
HW35_RS15700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HW35_RS15705	COG1561	YicC-like family, N-terminal region
HW35_RS15715	COG0194	GDP metabolic process
HW35_RS15725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW35_RS15730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW35_RS15735	COG0242	peptide deformylase activity
HW35_RS15740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW35_RS15745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW35_RS15745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW35_RS15750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HW35_RS15755	COG0631	protein serine/threonine phosphatase activity
HW35_RS15760	COG2815	serine threonine protein kinase
HW35_RS15760	COG0515	serine threonine protein kinase
HW35_RS15765	COG1162	GTPase activity
HW35_RS15770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW35_RS15775	COG1564	THIamine pyrophosphokinase
HW35_RS15785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW35_RS15790	COG1302	Protein conserved in bacteria
HW35_RS15795	COG1461	Dihydroxyacetone kinase
HW35_RS15800	COG1760	l-serine dehydratase
HW35_RS15805	COG1760	l-serine dehydratase
HW35_RS15810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW35_RS15815	COG1349	DNA-binding transcription factor activity
HW35_RS15825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW35_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_RS15840	COG0571	ribonuclease III activity
HW35_RS15845	COG1196	nuclear chromosome segregation
HW35_RS15850	COG0552	protein localization to endoplasmic reticulum
HW35_RS15855	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HW35_RS15860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW35_RS15870	COG1837	Belongs to the UPF0109 family
HW35_RS15880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HW35_RS15885	COG0336	Belongs to the RNA methyltransferase TrmD family
HW35_RS15890	COG0335	large ribosomal subunit rRNA binding
HW35_RS15910	COG0045	succinate-CoA ligase (ADP-forming) activity
HW35_RS15915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HW35_RS15920	COG0758	DNA mediated transformation
HW35_RS15925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW35_RS15930	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HW35_RS15935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HW35_RS15940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HW35_RS15945	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HW35_RS15950	COG0052	Belongs to the universal ribosomal protein uS2 family
HW35_RS15960	COG0528	UMP kinase activity
HW35_RS15965	COG0233	cytoplasmic translational termination
HW35_RS15970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW35_RS15975	COG4589	Belongs to the CDS family
HW35_RS15980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HW35_RS15985	COG0750	zinc metalloprotease
HW35_RS15990	COG2176	DNA-directed DNA polymerase activity
HW35_RS15995	COG0779	Required for maturation of 30S ribosomal subunits
HW35_RS16000	COG0195	Participates in both transcription termination and antitermination
HW35_RS16005	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HW35_RS16010	COG1358	cellular component organization or biogenesis
HW35_RS16015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW35_RS16020	COG1550	Protein conserved in bacteria
HW35_RS16025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HW35_RS16030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HW35_RS16035	COG0196	riboflavin kinase activity
HW35_RS16040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HW35_RS16045	COG1185	polyribonucleotide nucleotidyltransferase activity
HW35_RS16050	COG0726	polysaccharide deacetylase
HW35_RS16055	COG0612	Peptidase, M16
HW35_RS16060	COG1873	PFAM PRC-barrel domain
HW35_RS16065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW35_RS16070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW35_RS16075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HW35_RS16080	COG0527	aspartate kinase activity
HW35_RS16090	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW35_RS16095	COG0740	serine-type endopeptidase activity
HW35_RS16105	COG1674	ftsk spoiiie
HW35_RS16105	COG4980	gas vesicle protein
HW35_RS16110	COG2188	Transcriptional regulator
HW35_RS16115	COG1744	ABC transporter substrate-binding protein PnrA-like
HW35_RS16120	COG3845	ABC transporter
HW35_RS16125	COG4603	Belongs to the binding-protein-dependent transport system permease family
HW35_RS16130	COG1079	Belongs to the binding-protein-dependent transport system permease family
HW35_RS16135	COG0612	Peptidase, M16
HW35_RS16140	COG0612	Peptidase, M16
HW35_RS16145	COG0300	oxidoreductase activity
HW35_RS16160	COG1426	Protein conserved in bacteria
HW35_RS16165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW35_RS16170	COG1058	Belongs to the CinA family
HW35_RS16170	COG1546	Belongs to the CinA family
HW35_RS16185	COG1692	metallophosphoesterase
HW35_RS16190	COG2359	stage V sporulation protein S
HW35_RS16195	COG3344	reverse transcriptase
HW35_RS16200	COG0674	pyruvate-flavodoxin oxidoreductase activity
HW35_RS16200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HW35_RS16205	COG1013	pyruvate-flavodoxin oxidoreductase activity
HW35_RS16210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW35_RS16215	COG4550	Control of competence regulator ComK, YlbF/YmcA
HW35_RS16230	COG1119	ATPase activity
HW35_RS16235	COG0861	Integral membrane protein TerC family
HW35_RS16245	COG1846	Transcriptional regulator
HW35_RS16250	COG2259	Doxx family
HW35_RS16255	COG0346	lactoylglutathione lyase activity
HW35_RS16260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW35_RS16265	COG0346	lactoylglutathione lyase activity
HW35_RS16270	COG0400	carboxylic ester hydrolase activity
HW35_RS16275	COG2259	Doxx family
HW35_RS16280	COG0655	NAD(P)H dehydrogenase (quinone) activity
HW35_RS16300	COG5522	Integral membrane protein (intg_mem_TP0381)
HW35_RS16305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HW35_RS16310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HW35_RS16320	COG1077	Cell shape determining protein MreB Mrl
HW35_RS16325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HW35_RS16330	COG1923	regulation of RNA biosynthetic process
HW35_RS16335	COG0464	growth
HW35_RS16340	COG2860	membrane
HW35_RS16345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW35_RS16350	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HW35_RS16355	COG0789	Transcriptional regulator
HW35_RS16360	COG0174	glutamine synthetase
HW35_RS16365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW35_RS16375	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW35_RS16380	COG4224	UPF0291 protein
HW35_RS16390	COG2801	Transposase and inactivated derivatives
HW35_RS16400	COG3763	UPF0154 protein
HW35_RS16420	COG1132	(ABC) transporter
HW35_RS16425	COG1132	(ABC) transporter
HW35_RS16440	COG0785	Cytochrome C biogenesis protein
HW35_RS16445	COG4846	Membrane protein involved in cytochrome C biogenesis
HW35_RS16465	COG0305	Participates in initiation and elongation during chromosome replication
HW35_RS16475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HW35_RS16495	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW35_RS16530	COG0697	spore germination
HW35_RS16550	COG0730	response to heat
HW35_RS16560	COG2814	Major facilitator Superfamily
HW35_RS16575	COG0175	sulfate reduction
HW35_RS16580	COG2046	Belongs to the sulfate adenylyltransferase family
HW35_RS16585	COG0529	Catalyzes the synthesis of activated sulfate
HW35_RS16590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_RS16595	COG4191	Histidine kinase
HW35_RS16605	COG3344	reverse transcriptase
HW35_RS16620	COG0175	sulfate reduction
HW35_RS16625	COG0306	phosphate transporter
HW35_RS16630	COG2046	Belongs to the sulfate adenylyltransferase family
HW35_RS16635	COG0529	Catalyzes the synthesis of activated sulfate
HW35_RS16645	COG0531	amino acid
HW35_RS16650	COG0656	L-ascorbic acid biosynthetic process
HW35_RS16660	COG0833	amino acid
HW35_RS16675	COG0420	3'-5' exonuclease activity
HW35_RS16680	COG0419	ATPase involved in DNA repair
HW35_RS16690	COG2362	D-Aminopeptidase
HW35_RS16695	COG0601	transmembrane transport
HW35_RS16700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW35_RS16705	COG0444	Belongs to the ABC transporter superfamily
HW35_RS16710	COG4166	transmembrane transport
HW35_RS16715	COG1619	proteins homologs of microcin C7 resistance protein MccF
HW35_RS16720	COG4948	Mandelate Racemase Muconate Lactonizing
HW35_RS16725	COG0791	NLP P60 protein
HW35_RS16730	COG4608	Belongs to the ABC transporter superfamily
HW35_RS16740	COG2801	Transposase and inactivated derivatives
HW35_RS16750	COG2409	Drug exporters of the RND superfamily
HW35_RS16750	COG1033	growth of symbiont in host cell
HW35_RS16755	COG1846	Transcriptional regulator
HW35_RS16765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW35_RS16785	COG1473	amidohydrolase
HW35_RS16790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW35_RS16795	COG0006	proline dipeptidase activity
HW35_RS16800	COG2508	Transcriptional regulator
HW35_RS16805	COG2423	ornithine cyclodeaminase activity
HW35_RS16825	COG1012	belongs to the aldehyde dehydrogenase family
HW35_RS16830	COG0006	proline dipeptidase activity
HW35_RS16835	COG0477	Major facilitator Superfamily
HW35_RS16855	COG3190	flagellar
HW35_RS16885	COG5002	protein histidine kinase activity
HW35_RS16895	COG1388	LysM domain
HW35_RS16915	COG0726	polysaccharide deacetylase
HW35_RS16945	COG4193	domain, Protein
HW35_RS16980	COG1376	ErfK ybiS ycfS ynhG family protein
HW35_RS17005	COG0791	NLP P60 protein