locus-tag	class	description
CS527_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CS527_RS00010	COG0592	DNA-directed DNA polymerase activity
CS527_RS00015	COG2501	S4 domain
CS527_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CS527_RS00025	COG0187	DNA topoisomerase II activity
CS527_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CS527_RS00065	COG0516	GMP reductase activity
CS527_RS00065	COG0517	IMP dehydrogenase activity
CS527_RS00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CS527_RS00095	COG1428	Deoxynucleoside kinase
CS527_RS00100	COG1428	Deoxynucleoside kinase
CS527_RS00105	COG3858	chitin binding
CS527_RS00105	COG1388	LysM domain
CS527_RS00110	COG1335	isochorismatase
CS527_RS00115	COG0590	tRNA wobble adenosine to inosine editing
CS527_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CS527_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CS527_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CS527_RS00240	COG1982	Orn Lys Arg decarboxylase major
CS527_RS00245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CS527_RS00250	COG3870	Protein conserved in bacteria
CS527_RS00255	COG0470	DNA polymerase III
CS527_RS00260	COG1774	PSP1 C-terminal conserved region
CS527_RS00265	COG4467	Involved in initiation control of chromosome replication
CS527_RS00270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CS527_RS00275	COG2827	Endonuclease containing a URI domain
CS527_RS00280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CS527_RS00285	COG2002	toxin-antitoxin pair type II binding
CS527_RS00295	COG0084	hydrolase, TatD family'
CS527_RS00305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CS527_RS00315	COG4466	Protein conserved in bacteria
CS527_RS00330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CS527_RS00335	COG0251	oxidation-reduction process
CS527_RS00340	COG2088	sporulation resulting in formation of a cellular spore
CS527_RS00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CS527_RS00360	COG0193	aminoacyl-tRNA hydrolase activity
CS527_RS00370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CS527_RS00380	COG2002	toxin-antitoxin pair type II binding
CS527_RS00385	COG2244	polysaccharide biosynthetic process
CS527_RS00390	COG3956	TIGRFAM MazG family protein
CS527_RS00395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CS527_RS00410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CS527_RS00415	COG1098	S1 RNA binding domain
CS527_RS00435	COG2304	oxidoreductase activity
CS527_RS00440	COG0515	serine threonine protein kinase
CS527_RS00445	COG0037	tRNA processing
CS527_RS00450	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CS527_RS00455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CS527_RS00460	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CS527_RS00465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CS527_RS00470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CS527_RS00475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CS527_RS00480	COG0512	Glutamine amidotransferase of anthranilate synthase
CS527_RS00485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS527_RS00490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CS527_RS00495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CS527_RS00500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CS527_RS00525	COG3880	PFAM UvrB UvrC protein
CS527_RS00530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CS527_RS00535	COG0542	response to heat
CS527_RS00540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CS527_RS00545	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CS527_RS00550	COG4956	integral membrane protein (PIN domain superfamily)
CS527_RS00555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CS527_RS00565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CS527_RS00570	COG1045	serine acetyltransferase
CS527_RS00575	COG0215	cysteine-tRNA ligase activity
CS527_RS00585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS527_RS00590	COG3688	RNA-binding protein containing a PIN domain
CS527_RS00600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CS527_RS00605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CS527_RS00610	COG0250	Participates in transcription elongation, termination and antitermination
CS527_RS00615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CS527_RS00620	COG0081	regulation of translation
CS527_RS00625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CS527_RS00630	COG0222	ribosome binding
CS527_RS00635	COG2813	Specifically methylates the guanine in position
CS527_RS00640	COG0085	RNA polymerase activity
CS527_RS00650	COG1358	cellular component organization or biogenesis
CS527_RS00655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CS527_RS00660	COG0049	tRNA binding
CS527_RS00670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CS527_RS00675	COG0051	transcription antitermination factor activity, RNA binding
CS527_RS00680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CS527_RS00685	COG0088	Forms part of the polypeptide exit tunnel
CS527_RS00690	COG0089	rRNA binding
CS527_RS00695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CS527_RS00700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CS527_RS00705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CS527_RS00715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CS527_RS00720	COG0255	Belongs to the universal ribosomal protein uL29 family
CS527_RS00725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CS527_RS00730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CS527_RS00745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CS527_RS00760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CS527_RS00765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CS527_RS00770	COG1841	ribosomal large subunit assembly
CS527_RS00780	COG0201	protein transport
CS527_RS00785	COG0563	adenylate kinase activity
CS527_RS00790	COG0024	Methionine aminopeptidase
CS527_RS00795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CS527_RS00800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CS527_RS00805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CS527_RS00815	COG0202	RNA polymerase activity
CS527_RS00820	COG0203	ribosomal protein L17
CS527_RS00825	COG1122	ATPase activity
CS527_RS00830	COG1122	ATPase activity
CS527_RS00835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CS527_RS00840	COG0101	tRNA pseudouridine synthase activity
CS527_RS00845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CS527_RS00860	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_RS00865	COG0489	protein tyrosine kinase activity
CS527_RS00870	COG0583	DNA-binding transcription factor activity
CS527_RS00880	COG2194	sulfuric ester hydrolase activity
CS527_RS00885	COG0726	polysaccharide deacetylase
CS527_RS00965	COG1595	DNA-templated transcription, initiation
CS527_RS00970	COG5662	AntiSigma factor
CS527_RS00975	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CS527_RS00985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS527_RS00990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CS527_RS01005	COG0791	NLP P60 protein
CS527_RS01005	COG3103	Sh3 type 3 domain protein
CS527_RS01005	COG1388	LysM domain
CS527_RS01010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_RS01010	COG2213	PTS system mannitol-specific
CS527_RS01015	COG3711	transcriptional antiterminator
CS527_RS01020	COG0246	Mannitol dehydrogenase
CS527_RS01030	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_RS01035	COG1970	mechanosensitive ion channel activity
CS527_RS01040	COG1368	sulfuric ester hydrolase activity
CS527_RS01060	COG1177	transmembrane transport
CS527_RS01065	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CS527_RS01075	COG0745	RESPONSE REGULATOR receiver
CS527_RS01080	COG5002	protein histidine kinase activity
CS527_RS01095	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CS527_RS01095	COG3976	FMN-binding domain protein
CS527_RS01100	COG1181	Belongs to the D-alanine--D-alanine ligase family
CS527_RS01105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CS527_RS01110	COG0513	Belongs to the DEAD box helicase family
CS527_RS01115	COG4294	response to UV
CS527_RS01120	COG0705	Rhomboid family
CS527_RS01125	COG0736	holo-[acyl-carrier-protein] synthase activity
CS527_RS01130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CS527_RS01135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CS527_RS01140	COG0864	Transcriptional regulator
CS527_RS01145	COG2337	Toxic component of a toxin-antitoxin (TA) module
CS527_RS01150	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS01155	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS01160	COG2172	sigma factor antagonist activity
CS527_RS01165	COG2208	phosphoserine phosphatase activity
CS527_RS01170	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS01180	COG1191	sigma factor activity
CS527_RS01185	COG2208	phosphoserine phosphatase activity
CS527_RS01190	COG2183	response to ionizing radiation
CS527_RS01285	COG0802	atpase or kinase
CS527_RS01290	COG1214	PFAM Peptidase M22, glycoprotease
CS527_RS01295	COG0456	acetyltransferase
CS527_RS01305	COG0488	(ABC) transporter
CS527_RS01310	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CS527_RS01315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS527_RS01320	COG0805	protein transport
CS527_RS01330	COG1266	CAAX protease self-immunity
CS527_RS01335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CS527_RS01345	COG0714	Associated with various cellular activities
CS527_RS01350	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CS527_RS01355	COG1305	Transglutaminase-like
CS527_RS01360	COG0519	Catalyzes the synthesis of GMP from XMP
CS527_RS01360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CS527_RS01365	COG2252	PERMEase
CS527_RS01420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CS527_RS01425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CS527_RS01430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CS527_RS01435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CS527_RS01440	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CS527_RS01445	COG0047	phosphoribosylformylglycinamidine synthase activity
CS527_RS01450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CS527_RS01455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CS527_RS01460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CS527_RS01465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CS527_RS01470	COG0138	bifunctional purine biosynthesis protein purh
CS527_RS01475	COG0151	Belongs to the GarS family
CS527_RS01485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CS527_RS01490	COG4496	protein, YerC YecD
CS527_RS01495	COG0423	glycine-tRNA ligase activity
CS527_RS01505	COG0210	DNA helicase
CS527_RS01515	COG4851	CamS sex pheromone cAM373 precursor
CS527_RS01525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CS527_RS01530	COG0154	amidase activity
CS527_RS01540	COG1597	lipid kinase activity
CS527_RS01550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS01560	COG0166	Belongs to the GPI family
CS527_RS01565	COG1744	ABC transporter substrate-binding protein PnrA-like
CS527_RS01570	COG3852	Histidine kinase
CS527_RS01575	COG0024	Methionine aminopeptidase
CS527_RS01580	COG2706	6-phosphogluconolactonase activity
CS527_RS01590	COG0789	Transcriptional regulator
CS527_RS01590	COG4978	Transcriptional regulator
CS527_RS01595	COG2814	Major facilitator Superfamily
CS527_RS01605	COG1876	peptidase activity
CS527_RS01610	COG1126	abc transporter atp-binding protein
CS527_RS01615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_RS01620	COG0765	amino acid transport
CS527_RS01625	COG0765	amino acid transport
CS527_RS01630	COG1113	amino acid transport
CS527_RS01635	COG2733	membrane
CS527_RS01640	COG3212	peptidase
CS527_RS01645	COG3212	peptidase
CS527_RS01650	COG3850	Histidine kinase
CS527_RS01650	COG5002	protein histidine kinase activity
CS527_RS01655	COG0745	RESPONSE REGULATOR receiver
CS527_RS01660	COG2205	protein histidine kinase activity
CS527_RS01665	COG0745	RESPONSE REGULATOR receiver
CS527_RS01670	COG2311	Membrane
CS527_RS01685	COG0671	phosphoesterase, PA-phosphatase related
CS527_RS01690	COG1764	response to oxidative stress
CS527_RS01695	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CS527_RS01705	COG2259	Doxx family
CS527_RS01710	COG0693	protein deglycase activity
CS527_RS01720	COG2318	DinB family
CS527_RS01730	COG1115	amino acid carrier protein
CS527_RS01745	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CS527_RS01750	COG0598	Magnesium transport protein CorA
CS527_RS01755	COG3290	protein histidine kinase activity
CS527_RS01760	COG4565	transcriptional regulatory protein
CS527_RS01775	COG4191	Histidine kinase
CS527_RS01780	COG0513	Belongs to the DEAD box helicase family
CS527_RS01800	COG4842	Belongs to the WXG100 family
CS527_RS01805	COG5417	Belongs to the EsaB family
CS527_RS01810	COG4499	WXG100 protein secretion system (Wss), protein YukC
CS527_RS01815	COG0433	COG0433 Predicted ATPase
CS527_RS01815	COG1674	ftsk spoiiie
CS527_RS01820	COG1511	domain protein
CS527_RS01835	COG2356	endonuclease I
CS527_RS01845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CS527_RS01860	COG0488	(ABC) transporter
CS527_RS01870	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CS527_RS01880	COG1959	2 iron, 2 sulfur cluster binding
CS527_RS01885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CS527_RS01885	COG1017	nitric oxide dioxygenase activity
CS527_RS01895	COG0693	protein deglycase activity
CS527_RS01900	COG2340	Cysteine-rich secretory protein family
CS527_RS01905	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CS527_RS01910	COG4840	Belongs to the UPF0435 family
CS527_RS01915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CS527_RS01920	COG4980	gas vesicle protein
CS527_RS01925	COG1295	ribonuclease BN
CS527_RS01930	COG2217	Heavy metal translocating P-type atpase
CS527_RS01940	COG0640	Transcriptional regulator
CS527_RS01950	COG0477	Major facilitator Superfamily
CS527_RS01955	COG3479	Phenolic acid decarboxylase
CS527_RS01965	COG3871	stress protein (general stress protein 26)
CS527_RS01970	COG0387	Pfam Sodium calcium exchanger
CS527_RS01980	COG0535	radical SAM domain protein
CS527_RS02000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS527_RS02010	COG1113	amino acid transport
CS527_RS02015	COG5002	protein histidine kinase activity
CS527_RS02035	COG1090	epimerase
CS527_RS02045	COG4221	oxidoreductase activity
CS527_RS02065	COG1988	membrane-bound metal-dependent
CS527_RS02070	COG1194	a g-specific adenine glycosylase
CS527_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS02095	COG3557	Belongs to the UPF0374 family
CS527_RS02100	COG1132	(ABC) transporter
CS527_RS02105	COG4129	membrane
CS527_RS02110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CS527_RS02115	COG4555	ABC transporter
CS527_RS02135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CS527_RS02140	COG0735	belongs to the Fur family
CS527_RS02250	COG4974	Belongs to the 'phage' integrase family
CS527_RS02340	COG3382	B3 4 domain protein
CS527_RS02355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CS527_RS02360	COG2766	serine protein kinase
CS527_RS02375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS527_RS02390	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CS527_RS02400	COG1968	undecaprenyl-diphosphatase activity
CS527_RS02405	COG1301	dicarboxylic acid transport
CS527_RS02410	COG0628	permease
CS527_RS02415	COG0586	Pfam SNARE associated Golgi protein
CS527_RS02420	COG2217	Heavy metal translocating P-type atpase
CS527_RS02425	COG0531	amino acid
CS527_RS02440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CS527_RS02445	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CS527_RS02450	COG3842	ATPase activity
CS527_RS02455	COG1175	transmembrane transport
CS527_RS02470	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_RS02485	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_RS02530	COG3583	domain protein
CS527_RS02530	COG3584	3D domain protein
CS527_RS02535	COG1876	peptidase activity
CS527_RS02545	COG3103	Sh3 type 3 domain protein
CS527_RS02550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS02550	COG0456	acetyltransferase
CS527_RS02560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_RS02580	COG1609	Transcriptional regulator
CS527_RS02585	COG2814	Major facilitator Superfamily
CS527_RS02590	COG0673	inositol 2-dehydrogenase activity
CS527_RS02615	COG1609	Transcriptional regulator
CS527_RS02630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS02635	COG1522	sequence-specific DNA binding
CS527_RS02655	COG2814	Major facilitator Superfamily
CS527_RS02660	COG1309	transcriptional regulator
CS527_RS02665	COG1187	pseudouridine synthase activity
CS527_RS02675	COG1942	4-Oxalocrotonate Tautomerase
CS527_RS02680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CS527_RS02685	COG0747	negative chemotaxis
CS527_RS02705	COG0084	hydrolase, TatD family'
CS527_RS02710	COG2962	Rard protein
CS527_RS02720	COG0628	permease
CS527_RS02735	COG0604	alcohol dehydrogenase
CS527_RS02740	COG1620	l-lactate permease
CS527_RS02750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS527_RS02755	COG0840	transmembrane signaling receptor activity
CS527_RS02760	COG0564	pseudouridine synthase activity
CS527_RS02770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS527_RS02775	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_RS02780	COG3153	acetyltransferase
CS527_RS02780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_RS02785	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CS527_RS02790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CS527_RS02800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CS527_RS02805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS527_RS02810	COG1268	BioY protein
CS527_RS02820	COG2719	SpoVR family
CS527_RS02830	COG1959	2 iron, 2 sulfur cluster binding
CS527_RS02835	COG0604	alcohol dehydrogenase
CS527_RS02845	COG1126	abc transporter atp-binding protein
CS527_RS02850	COG0765	amino acid transport
CS527_RS02855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_RS02860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CS527_RS02865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CS527_RS02875	COG0352	thiamine-phosphate diphosphorylase activity
CS527_RS02880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS527_RS02895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CS527_RS02900	COG0351	phosphomethylpyrimidine kinase
CS527_RS02915	COG0702	epimerase
CS527_RS02920	COG1253	flavin adenine dinucleotide binding
CS527_RS02935	COG3842	ATPase activity
CS527_RS02940	COG2508	Transcriptional regulator
CS527_RS02955	COG0189	ligase activity
CS527_RS02960	COG0189	ligase activity
CS527_RS02970	COG3679	Belongs to the UPF0342 family
CS527_RS02975	COG0561	phosphatase activity
CS527_RS02980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CS527_RS02985	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_RS02990	COG1024	Enoyl-CoA hydratase
CS527_RS03005	COG4152	abc transporter atp-binding protein
CS527_RS03010	COG1668	transmembrane transport
CS527_RS03020	COG3481	metal-dependent phosphohydrolase, HD sub domain
CS527_RS03030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS527_RS03055	COG1846	Transcriptional regulator
CS527_RS03070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CS527_RS03075	COG1695	Transcriptional regulator
CS527_RS03080	COG2153	protein acetylation
CS527_RS03085	COG2755	lipolytic protein G-D-S-L family
CS527_RS03085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CS527_RS03090	COG0537	adenosine 5'-monophosphoramidase activity
CS527_RS03095	COG1131	(ABC) transporter
CS527_RS03100	COG4473	ABC transporter
CS527_RS03110	COG1473	amidohydrolase
CS527_RS03115	COG0671	phosphoesterase, PA-phosphatase related
CS527_RS03120	COG3069	C4-dicarboxylate transmembrane transporter activity
CS527_RS03125	COG2329	Antibiotic biosynthesis monooxygenase
CS527_RS03130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS527_RS03135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CS527_RS03140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CS527_RS03145	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CS527_RS03150	COG1309	transcriptional regulator
CS527_RS03155	COG0768	penicillin binding
CS527_RS03165	COG2972	Histidine kinase
CS527_RS03180	COG1234	tRNA 3'-trailer cleavage
CS527_RS03185	COG0095	Lipoate-protein ligase
CS527_RS03190	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_RS03195	COG1024	Enoyl-CoA hydratase
CS527_RS03310	COG0501	Belongs to the peptidase M48B family
CS527_RS03315	COG2224	Isocitrate lyase
CS527_RS03325	COG0823	Involved in the tonB-independent uptake of proteins
CS527_RS03325	COG4946	Tricorn protease homolog
CS527_RS03325	COG1506	peptidase
CS527_RS03330	COG0398	Pfam SNARE associated Golgi protein
CS527_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS03340	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CS527_RS03345	COG1074	ATP-dependent DNA helicase activity
CS527_RS03350	COG0420	3'-5' exonuclease activity
CS527_RS03355	COG0419	ATPase involved in DNA repair
CS527_RS03360	COG1403	HNH endonuclease
CS527_RS03395	COG2311	Membrane
CS527_RS03410	COG0367	asparagine synthase
CS527_RS03425	COG1562	ergosterol biosynthetic process
CS527_RS03430	COG0347	Belongs to the P(II) protein family
CS527_RS03435	COG0004	ammonium transporteR
CS527_RS03440	COG1874	Beta-galactosidase
CS527_RS03440	COG0366	Alpha amylase catalytic
CS527_RS03445	COG1609	Transcriptional regulator
CS527_RS03450	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS03455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CS527_RS03460	COG4187	Peptidase family M20/M25/M40
CS527_RS03465	COG0833	amino acid
CS527_RS03470	COG3829	transcription factor binding
CS527_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS03480	COG1666	GTP binding
CS527_RS03485	COG2996	Protein conserved in bacteria
CS527_RS03495	COG1307	EDD domain protein, DegV family
CS527_RS03500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS03510	COG0561	phosphatase activity
CS527_RS03515	COG2151	metal-sulfur cluster biosynthetic enzyme
CS527_RS03520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS527_RS03525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CS527_RS03530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CS527_RS03535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CS527_RS03555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CS527_RS03570	COG0542	response to heat
CS527_RS03585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CS527_RS03590	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CS527_RS03595	COG2084	Dehydrogenase
CS527_RS03605	COG2267	carboxylic ester hydrolase activity
CS527_RS03625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS527_RS03630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CS527_RS03635	COG5504	Zn-dependent protease
CS527_RS03640	COG0444	Belongs to the ABC transporter superfamily
CS527_RS03645	COG4608	Belongs to the ABC transporter superfamily
CS527_RS03655	COG0601	transmembrane transport
CS527_RS03670	COG0180	Tryptophanyl-tRNA synthetase
CS527_RS03680	COG4166	transmembrane transport
CS527_RS03685	COG0601	transmembrane transport
CS527_RS03690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS527_RS03695	COG0444	Belongs to the ABC transporter superfamily
CS527_RS03700	COG4608	Belongs to the ABC transporter superfamily
CS527_RS03705	COG0456	acetyltransferase
CS527_RS03710	COG1113	amino acid transport
CS527_RS03720	COG0531	amino acid
CS527_RS03725	COG1393	Belongs to the ArsC family
CS527_RS03730	COG0583	DNA-binding transcription factor activity
CS527_RS03745	COG0861	Integral membrane protein TerC family
CS527_RS03755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_RS03765	COG1164	Oligoendopeptidase f
CS527_RS03775	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS527_RS03780	COG2346	COG2346, Truncated hemoglobins
CS527_RS03785	COG0741	lytic transglycosylase activity
CS527_RS03790	COG4116	CYTH
CS527_RS03800	COG2357	RelA SpoT domain protein
CS527_RS03810	COG0564	pseudouridine synthase activity
CS527_RS03820	COG2239	Acts as a magnesium transporter
CS527_RS03825	COG0569	domain protein
CS527_RS03825	COG0475	glutathione-regulated potassium exporter activity
CS527_RS03880	COG0210	DNA helicase
CS527_RS03890	COG2323	membrane
CS527_RS03895	COG2153	protein acetylation
CS527_RS03905	COG2382	esterase
CS527_RS03915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CS527_RS03925	COG1737	Transcriptional regulator
CS527_RS03930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CS527_RS03935	COG1070	Carbohydrate kinase
CS527_RS03940	COG1953	Uracil, thiamine, allantoin
CS527_RS03960	COG1522	sequence-specific DNA binding
CS527_RS03970	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS527_RS03985	COG3142	Participates in the control of copper homeostasis
CS527_RS03990	COG1113	amino acid transport
CS527_RS04000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_RS04005	COG1309	transcriptional regulator
CS527_RS04010	COG3711	transcriptional antiterminator
CS527_RS04010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_RS04015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS527_RS04020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS527_RS04025	COG1447	Phosphotransferase system cellobiose-specific component IIA
CS527_RS04030	COG1486	melibiose metabolic process
CS527_RS04035	COG3275	phosphorelay sensor kinase activity
CS527_RS04040	COG3279	Response regulator of the LytR AlgR family
CS527_RS04050	COG1346	cytolysis
CS527_RS04060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS527_RS04065	COG0243	molybdopterin cofactor binding
CS527_RS04070	COG2223	nitrite transmembrane transporter activity
CS527_RS04075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CS527_RS04090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CS527_RS04105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CS527_RS04105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CS527_RS04115	COG3527	Alpha-acetolactate decarboxylase
CS527_RS04120	COG0028	Belongs to the TPP enzyme family
CS527_RS04130	COG4895	conserved protein (DUF2196)
CS527_RS04140	COG1733	regulation of RNA biosynthetic process
CS527_RS04145	COG2814	Major facilitator Superfamily
CS527_RS04150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS04175	COG3052	prosthetic group binding
CS527_RS04190	COG0784	Response regulator, receiver
CS527_RS04195	COG4191	Histidine kinase
CS527_RS04200	COG2066	Belongs to the glutaminase family
CS527_RS04205	COG1115	amino acid carrier protein
CS527_RS04210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_RS04220	COG4297	protein containing double-stranded beta helix domain
CS527_RS04225	COG0531	amino acid
CS527_RS04235	COG1607	acyl-coa hydrolase
CS527_RS04240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CS527_RS04255	COG0390	transport system, permease component
CS527_RS04260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CS527_RS04275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CS527_RS04280	COG1136	(ABC) transporter
CS527_RS04285	COG0577	efflux transmembrane transporter activity
CS527_RS04295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CS527_RS04300	COG1063	alcohol dehydrogenase
CS527_RS04315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CS527_RS04320	COG0833	amino acid
CS527_RS04330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CS527_RS04335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS527_RS04345	COG0861	Integral membrane protein TerC family
CS527_RS04350	COG1301	dicarboxylic acid transport
CS527_RS04355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CS527_RS04360	COG3290	protein histidine kinase activity
CS527_RS04400	COG1476	TRANSCRIPTIONal
CS527_RS04410	COG1368	sulfuric ester hydrolase activity
CS527_RS04425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS04430	COG2040	homocysteine
CS527_RS04440	COG0179	Fumarylacetoacetate (FAA) hydrolase
CS527_RS04460	COG3290	protein histidine kinase activity
CS527_RS04465	COG4565	transcriptional regulatory protein
CS527_RS04470	COG3181	Tripartite tricarboxylate transporter family receptor
CS527_RS04480	COG0583	DNA-binding transcription factor activity
CS527_RS04485	COG3180	Ammonia monooxygenase
CS527_RS04490	COG2226	methyltransferase
CS527_RS04500	COG4175	Glycine betaine
CS527_RS04500	COG0517	IMP dehydrogenase activity
CS527_RS04505	COG2113	Glycine betaine
CS527_RS04510	COG1309	transcriptional regulator
CS527_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS04530	COG0531	amino acid
CS527_RS04535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CS527_RS04540	COG1464	Belongs to the NlpA lipoprotein family
CS527_RS04545	COG2011	ABC-type metal ion transport system permease component
CS527_RS04550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS527_RS04565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS04575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CS527_RS04580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_RS04585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_RS04610	COG1737	Transcriptional regulator
CS527_RS04615	COG1263	PTS System
CS527_RS04615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_RS04625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS527_RS04630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CS527_RS04635	COG1116	anion transmembrane transporter activity
CS527_RS04640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS527_RS04645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS527_RS04655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CS527_RS04660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CS527_RS04665	COG1733	regulation of RNA biosynthetic process
CS527_RS04700	COG1511	domain protein
CS527_RS04710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CS527_RS04715	COG1733	regulation of RNA biosynthetic process
CS527_RS04725	COG1132	(ABC) transporter
CS527_RS04730	COG1132	(ABC) transporter
CS527_RS04740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_RS04745	COG3162	membrane
CS527_RS04755	COG1414	Transcriptional regulator
CS527_RS04760	COG0656	L-ascorbic acid biosynthetic process
CS527_RS04765	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CS527_RS04770	COG1846	Transcriptional regulator
CS527_RS04775	COG1566	PFAM secretion protein HlyD family protein
CS527_RS04780	COG2814	Major facilitator Superfamily
CS527_RS04785	COG0655	NAD(P)H dehydrogenase (quinone) activity
CS527_RS04800	COG1609	Transcriptional regulator
CS527_RS04805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_RS04815	COG1129	ABC transporter
CS527_RS04820	COG1172	Belongs to the binding-protein-dependent transport system permease family
CS527_RS04825	COG1879	ABC-type sugar transport system periplasmic component
CS527_RS04830	COG3584	3D domain protein
CS527_RS04830	COG3583	domain protein
CS527_RS04840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CS527_RS04845	COG1653	transport
CS527_RS04890	COG0745	RESPONSE REGULATOR receiver
CS527_RS04895	COG5002	protein histidine kinase activity
CS527_RS04905	COG2267	carboxylic ester hydrolase activity
CS527_RS04920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CS527_RS04935	COG0402	S-adenosylhomocysteine deaminase activity
CS527_RS04940	COG2252	PERMEase
CS527_RS04945	COG1609	Transcriptional regulator
CS527_RS04950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CS527_RS04955	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS04965	COG0710	3-dehydroquinate dehydratase activity
CS527_RS04975	COG1263	PTS System
CS527_RS04975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_RS04980	COG0366	Alpha amylase catalytic
CS527_RS04985	COG2188	Transcriptional regulator
CS527_RS04995	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CS527_RS05000	COG1984	allophanate hydrolase subunit 2
CS527_RS05005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CS527_RS05010	COG1914	H( )-stimulated, divalent metal cation uptake system
CS527_RS05015	COG1272	protein, Hemolysin III
CS527_RS05030	COG0778	Nitroreductase
CS527_RS05035	COG0628	permease
CS527_RS05065	COG2271	Major facilitator Superfamily
CS527_RS05070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CS527_RS05075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CS527_RS05080	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS05090	COG0402	S-adenosylhomocysteine deaminase activity
CS527_RS05095	COG1278	Cold shock
CS527_RS05100	COG2910	NAD(P)H-binding
CS527_RS05105	COG0673	inositol 2-dehydrogenase activity
CS527_RS05110	COG0450	alkyl hydroperoxide reductase
CS527_RS05115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_RS05150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS527_RS05230	COG1649	PFAM Uncharacterised BCR, COG1649
CS527_RS05235	COG1737	Transcriptional regulator
CS527_RS05255	COG1486	melibiose metabolic process
CS527_RS05265	COG1447	Phosphotransferase system cellobiose-specific component IIA
CS527_RS05275	COG2971	BadF BadG BcrA BcrD
CS527_RS05280	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CS527_RS05285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_RS05295	COG3037	sugar-specific permease SgaT UlaA
CS527_RS05300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_RS05300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CS527_RS05310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CS527_RS05325	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_RS05330	COG4106	trans-aconitate 2-methyltransferase activity
CS527_RS05335	COG0583	DNA-binding transcription factor activity
CS527_RS05345	COG0667	Aldo Keto reductase
CS527_RS05375	COG1132	(ABC) transporter
CS527_RS05390	COG0154	amidase activity
CS527_RS05400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CS527_RS05440	COG2200	EAL domain
CS527_RS05440	COG2199	diguanylate cyclase activity
CS527_RS05450	COG1733	regulation of RNA biosynthetic process
CS527_RS05465	COG0385	Bile acid
CS527_RS05475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_RS05480	COG4191	Histidine kinase
CS527_RS05485	COG0784	Response regulator, receiver
CS527_RS05500	COG1388	LysM domain
CS527_RS05500	COG0791	NLP P60 protein
CS527_RS05510	COG2385	sporulation resulting in formation of a cellular spore
CS527_RS05515	COG0656	L-ascorbic acid biosynthetic process
CS527_RS05530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CS527_RS05535	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_RS05555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CS527_RS05570	COG0477	Major facilitator Superfamily
CS527_RS05575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CS527_RS05585	COG0640	Transcriptional regulator
CS527_RS05590	COG5658	integral membrane protein
CS527_RS05610	COG3300	MHYT domain
CS527_RS05610	COG5001	Diguanylate cyclase
CS527_RS05615	COG0302	gtp cyclohydrolase
CS527_RS05635	COG2843	Capsule synthesis protein
CS527_RS05650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CS527_RS05685	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CS527_RS05715	COG4464	protein tyrosine phosphatase activity
CS527_RS05720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CS527_RS05725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS527_RS05740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CS527_RS05745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CS527_RS05750	COG0438	transferase activity, transferring glycosyl groups
CS527_RS05775	COG2244	polysaccharide biosynthetic process
CS527_RS05780	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CS527_RS05790	COG3944	biosynthesis protein
CS527_RS05795	COG0489	protein tyrosine kinase activity
CS527_RS05800	COG1316	TRANSCRIPTIONal
CS527_RS05820	COG0028	Belongs to the TPP enzyme family
CS527_RS05825	COG0069	glutamate synthase activity
CS527_RS05870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS527_RS05875	COG2146	nitrite reductase [NAD(P)H] activity
CS527_RS05885	COG2116	formate transmembrane transporter activity
CS527_RS05895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_RS05900	COG4975	Glucose uptake
CS527_RS05915	COG0534	Mate efflux family protein
CS527_RS05925	COG1316	TRANSCRIPTIONal
CS527_RS05935	COG0598	Magnesium transport protein CorA
CS527_RS05940	COG1404	Belongs to the peptidase S8 family
CS527_RS05965	COG4821	SIS domain
CS527_RS05970	COG2188	Transcriptional regulator
CS527_RS05975	COG0363	glucosamine-6-phosphate deaminase activity
CS527_RS05980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CS527_RS05985	COG1263	PTS System
CS527_RS05985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_RS05985	COG2190	(PTS) system
CS527_RS05990	COG1811	Na channel or pump
CS527_RS05995	COG3961	Belongs to the TPP enzyme family
CS527_RS06030	COG1131	(ABC) transporter
CS527_RS06035	COG1253	flavin adenine dinucleotide binding
CS527_RS06040	COG0789	Transcriptional regulator
CS527_RS06050	COG0346	lactoylglutathione lyase activity
CS527_RS06055	COG2105	PFAM AIG2 family protein
CS527_RS06055	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CS527_RS06100	COG0456	acetyltransferase
CS527_RS06105	COG1473	amidohydrolase
CS527_RS06115	COG4187	Peptidase family M20/M25/M40
CS527_RS06130	COG0456	acetyltransferase
CS527_RS06130	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CS527_RS06150	COG2252	PERMEase
CS527_RS06160	COG3279	Response regulator of the LytR AlgR family
CS527_RS06165	COG4555	ABC transporter
CS527_RS06170	COG1668	transmembrane transport
CS527_RS06180	COG0789	Transcriptional regulator
CS527_RS06185	COG1846	Transcriptional regulator
CS527_RS06190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CS527_RS06190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CS527_RS06210	COG1785	Belongs to the alkaline phosphatase family
CS527_RS06215	COG3279	Response regulator of the LytR AlgR family
CS527_RS06220	COG2205	protein histidine kinase activity
CS527_RS06220	COG0784	Response regulator, receiver
CS527_RS06225	COG0861	Integral membrane protein TerC family
CS527_RS06230	COG1191	sigma factor activity
CS527_RS06260	COG3243	poly(R)-hydroxyalkanoic acid synthase
CS527_RS06265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CS527_RS06275	COG2186	Transcriptional regulator
CS527_RS06280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CS527_RS06290	COG0247	lactate metabolic process
CS527_RS06295	COG1139	Iron-sulfur cluster binding protein
CS527_RS06300	COG1556	Lactate utilization protein
CS527_RS06305	COG5002	protein histidine kinase activity
CS527_RS06310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CS527_RS06315	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CS527_RS06320	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CS527_RS06325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_RS06330	COG0436	Aminotransferase
CS527_RS06335	COG1850	ribulose-bisphosphate carboxylase activity
CS527_RS06340	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CS527_RS06345	COG0235	Class ii aldolase
CS527_RS06350	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CS527_RS06360	COG1129	ABC transporter
CS527_RS06365	COG1172	Belongs to the binding-protein-dependent transport system permease family
CS527_RS06395	COG1846	Transcriptional regulator
CS527_RS06405	COG4191	Histidine kinase
CS527_RS06415	COG0542	response to heat
CS527_RS06420	COG1757	Na H antiporter
CS527_RS06430	COG0300	oxidoreductase activity
CS527_RS06435	COG0697	spore germination
CS527_RS06455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CS527_RS06460	COG0720	synthase
CS527_RS06470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CS527_RS06475	COG0702	epimerase
CS527_RS06485	COG4873	Protein conserved in bacteria
CS527_RS06505	COG3773	Cell wall hydrolase
CS527_RS06545	COG0646	methionine synthase
CS527_RS06545	COG1410	methionine synthase
CS527_RS06550	COG0646	methionine synthase
CS527_RS06550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CS527_RS06555	COG3949	Membrane
CS527_RS06565	COG0307	riboflavin synthase, alpha
CS527_RS06575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CS527_RS06585	COG3711	transcriptional antiterminator
CS527_RS06590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_RS06590	COG2190	(PTS) system
CS527_RS06590	COG1263	PTS System
CS527_RS06605	COG1346	cytolysis
CS527_RS06615	COG0583	DNA-binding transcription factor activity
CS527_RS06625	COG0456	acetyltransferase
CS527_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS06635	COG0778	Nitroreductase
CS527_RS06640	COG0436	Aminotransferase
CS527_RS06660	COG0784	Response regulator, receiver
CS527_RS06660	COG0835	chemotaxis
CS527_RS06670	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_RS06675	COG0248	Ppx GppA phosphatase
CS527_RS06690	COG1408	metallophosphoesterase
CS527_RS06695	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS06700	COG2200	EAL domain
CS527_RS06715	COG4703	Protein of unknown function (DUF1797)
CS527_RS06720	COG0517	IMP dehydrogenase activity
CS527_RS06725	COG0583	DNA-binding transcription factor activity
CS527_RS06730	COG2171	N-acyltransferase activity
CS527_RS06735	COG1473	amidohydrolase
CS527_RS06745	COG0668	transmembrane transport
CS527_RS06750	COG0450	alkyl hydroperoxide reductase
CS527_RS06755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_RS06760	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CS527_RS06765	COG1132	(ABC) transporter
CS527_RS06770	COG1132	(ABC) transporter
CS527_RS06775	COG0569	domain protein
CS527_RS06780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CS527_RS06785	COG5503	Protein of unknown function (DUF1447)
CS527_RS06790	COG0561	phosphatase activity
CS527_RS06815	COG0022	dehydrogenase e1 component
CS527_RS06820	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_RS06845	COG1982	Orn Lys Arg decarboxylase major
CS527_RS06850	COG4476	Belongs to the UPF0223 family
CS527_RS06855	COG4493	Belongs to the UPF0637 family
CS527_RS06865	COG0483	inositol monophosphate 1-phosphatase activity
CS527_RS06875	COG1217	gtp-binding protein TYPA
CS527_RS06890	COG4896	Protein conserved in bacteria
CS527_RS06905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CS527_RS06910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CS527_RS06915	COG4838	Belongs to the UPF0358 family
CS527_RS06920	COG0772	Belongs to the SEDS family
CS527_RS06925	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CS527_RS06930	COG1612	heme a metabolic process
CS527_RS06935	COG0109	protoheme IX farnesyltransferase activity
CS527_RS06960	COG3336	cytochrome c oxidase
CS527_RS06970	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CS527_RS06975	COG2340	Cysteine-rich secretory protein family
CS527_RS06985	COG2738	Putative neutral zinc metallopeptidase
CS527_RS06990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS06995	COG1694	Mazg nucleotide pyrophosphohydrolase
CS527_RS07000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CS527_RS07005	COG1803	Methylglyoxal synthase
CS527_RS07010	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS527_RS07015	COG0438	transferase activity, transferring glycosyl groups
CS527_RS07020	COG0617	tRNA 3'-terminal CCA addition
CS527_RS07025	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CS527_RS07025	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CS527_RS07035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CS527_RS07040	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CS527_RS07045	COG1199	ATP-dependent helicase activity
CS527_RS07045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CS527_RS07065	COG0436	Aminotransferase
CS527_RS07070	COG0017	Asparaginyl-tRNA synthetase
CS527_RS07075	COG3935	DnaD domain protein
CS527_RS07080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CS527_RS07090	COG4499	WXG100 protein secretion system (Wss), protein YukC
CS527_RS07090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS527_RS07095	COG3331	DNA recombination
CS527_RS07130	COG5337	Spore coat protein CotH
CS527_RS07145	COG0626	cystathionine gamma-synthase activity
CS527_RS07150	COG0626	cystathionine gamma-synthase activity
CS527_RS07165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_RS07245	COG2197	response regulator
CS527_RS07250	COG0366	Alpha amylase catalytic
CS527_RS07255	COG0116	Belongs to the methyltransferase superfamily
CS527_RS07270	COG1175	transmembrane transport
CS527_RS07280	COG3842	ATPase activity
CS527_RS07290	COG1199	ATP-dependent helicase activity
CS527_RS07295	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CS527_RS07300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CS527_RS07305	COG2233	PERMEase
CS527_RS07310	COG0583	DNA-binding transcription factor activity
CS527_RS07315	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS07325	COG3424	synthase
CS527_RS07330	COG1755	Isoprenylcysteine carboxyl methyltransferase
CS527_RS07335	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CS527_RS07340	COG3541	Predicted nucleotidyltransferase
CS527_RS07365	COG0328	RNA-DNA hybrid ribonuclease activity
CS527_RS07370	COG0328	RNA-DNA hybrid ribonuclease activity
CS527_RS07395	COG2814	Major facilitator Superfamily
CS527_RS07405	COG2233	PERMEase
CS527_RS07410	COG2362	D-Aminopeptidase
CS527_RS07415	COG0601	transmembrane transport
CS527_RS07420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS527_RS07425	COG0444	Belongs to the ABC transporter superfamily
CS527_RS07430	COG4166	transmembrane transport
CS527_RS07435	COG1619	proteins homologs of microcin C7 resistance protein MccF
CS527_RS07440	COG0791	NLP P60 protein
CS527_RS07445	COG4608	Belongs to the ABC transporter superfamily
CS527_RS07465	COG3300	MHYT domain
CS527_RS07465	COG5001	Diguanylate cyclase
CS527_RS07495	COG2197	response regulator
CS527_RS07500	COG4585	Histidine kinase
CS527_RS07505	COG3239	Fatty acid desaturase
CS527_RS07510	COG2205	protein histidine kinase activity
CS527_RS07520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_RS07535	COG1388	LysM domain
CS527_RS07535	COG0791	NLP P60 protein
CS527_RS07540	COG1819	glycosyl
CS527_RS07545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS527_RS07560	COG2814	Major facilitator Superfamily
CS527_RS07570	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS07575	COG3964	amidohydrolase
CS527_RS07595	COG2188	Transcriptional regulator
CS527_RS07605	COG0434	BtpA family
CS527_RS07610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CS527_RS07620	COG1785	Belongs to the alkaline phosphatase family
CS527_RS07625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS527_RS07630	COG1404	Belongs to the peptidase S8 family
CS527_RS07640	COG1846	Transcriptional regulator
CS527_RS07645	COG1566	PFAM secretion protein HlyD family protein
CS527_RS07650	COG2814	Major facilitator Superfamily
CS527_RS07655	COG1846	Transcriptional regulator
CS527_RS07675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_RS07680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_RS07685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_RS07690	COG1120	ATPase activity
CS527_RS07695	COG0492	ferredoxin-NADP+ reductase activity
CS527_RS07705	COG2814	Major facilitator Superfamily
CS527_RS07725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CS527_RS07730	COG1733	regulation of RNA biosynthetic process
CS527_RS07745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS527_RS07755	COG4175	Glycine betaine
CS527_RS07755	COG3448	diguanylate cyclase activity
CS527_RS07770	COG2205	protein histidine kinase activity
CS527_RS07770	COG0784	Response regulator, receiver
CS527_RS07775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CS527_RS07780	COG2208	phosphoserine phosphatase activity
CS527_RS07790	COG0531	amino acid
CS527_RS07800	COG1011	Hydrolase
CS527_RS07805	COG0405	Gamma-glutamyltransferase
CS527_RS07810	COG1621	beta-fructofuranosidase activity
CS527_RS07815	COG1621	beta-fructofuranosidase activity
CS527_RS07820	COG2193	ferroxidase activity
CS527_RS07825	COG0477	Major facilitator Superfamily
CS527_RS07835	COG0156	8-amino-7-oxononanoate synthase activity
CS527_RS07840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS527_RS07850	COG2814	Major facilitator Superfamily
CS527_RS07865	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS07870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_RS07880	COG1280	lysine exporter protein (LysE YggA)
CS527_RS07885	COG1113	amino acid transport
CS527_RS07895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CS527_RS07920	COG1113	amino acid transport
CS527_RS07940	COG1609	Transcriptional regulator
CS527_RS07955	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CS527_RS07960	COG1621	beta-fructofuranosidase activity
CS527_RS07965	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CS527_RS07965	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CS527_RS07970	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_RS07975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_RS07980	COG3715	PTS system
CS527_RS07985	COG3716	PTS system mannose fructose sorbose family IID component
CS527_RS07990	COG1621	beta-fructofuranosidase activity
CS527_RS07995	COG0765	amino acid transport
CS527_RS08000	COG0765	amino acid transport
CS527_RS08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_RS08010	COG1464	Belongs to the NlpA lipoprotein family
CS527_RS08015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS527_RS08020	COG2011	ABC-type metal ion transport system permease component
CS527_RS08040	COG1464	Belongs to the NlpA lipoprotein family
CS527_RS08045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS527_RS08050	COG2011	ABC-type metal ion transport system permease component
CS527_RS08055	COG1464	Belongs to the NlpA lipoprotein family
CS527_RS08060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS08065	COG0024	Methionine aminopeptidase
CS527_RS08085	COG0596	Alpha beta hydrolase
CS527_RS08090	COG0697	spore germination
CS527_RS08105	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS527_RS08110	COG0531	amino acid
CS527_RS08125	COG2723	6-phospho-beta-galactosidase activity
CS527_RS08130	COG2188	Transcriptional regulator
CS527_RS08140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CS527_RS08150	COG0656	L-ascorbic acid biosynthetic process
CS527_RS08155	COG2986	histidine ammonia-lyase
CS527_RS08160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CS527_RS08165	COG1228	amidohydrolase
CS527_RS08170	COG0010	Belongs to the arginase family
CS527_RS08175	COG1846	Transcriptional regulator
CS527_RS08190	COG1288	antiporter activity
CS527_RS08195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CS527_RS08225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS08245	COG2364	Membrane
CS527_RS08250	COG1846	Transcriptional regulator
CS527_RS08255	COG0456	acetyltransferase
CS527_RS08290	COG0574	Belongs to the PEP-utilizing enzyme family
CS527_RS08290	COG3848	Pyruvate phosphate dikinase
CS527_RS08295	COG1309	transcriptional regulator
CS527_RS08300	COG2814	Major facilitator Superfamily
CS527_RS08305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CS527_RS08310	COG3958	Transketolase
CS527_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS08320	COG2186	Transcriptional regulator
CS527_RS08330	COG0205	6-phosphofructokinase activity
CS527_RS08340	COG0698	ribose 5-phosphate isomerase
CS527_RS08365	COG0791	NLP P60 protein
CS527_RS08365	COG1388	LysM domain
CS527_RS08370	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CS527_RS08385	COG2318	DinB family
CS527_RS08410	COG0583	DNA-binding transcription factor activity
CS527_RS08415	COG0596	Alpha beta hydrolase
CS527_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS08480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS527_RS08490	COG0697	spore germination
CS527_RS08520	COG0387	Pfam Sodium calcium exchanger
CS527_RS08525	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_RS08540	COG1309	transcriptional regulator
CS527_RS08545	COG0861	Integral membrane protein TerC family
CS527_RS08555	COG5577	PFAM Coat F domain
CS527_RS08570	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS08580	COG1522	sequence-specific DNA binding
CS527_RS08585	COG3813	Protein conserved in bacteria
CS527_RS08610	COG2076	Multidrug Resistance protein
CS527_RS08635	COG1278	Cold shock
CS527_RS08645	COG0513	Belongs to the DEAD box helicase family
CS527_RS08650	COG1278	Cold shock
CS527_RS08700	COG0747	negative chemotaxis
CS527_RS08705	COG0601	transmembrane transport
CS527_RS08715	COG0444	Belongs to the ABC transporter superfamily
CS527_RS08720	COG4608	Belongs to the ABC transporter superfamily
CS527_RS08725	COG0534	Mate efflux family protein
CS527_RS08745	COG2172	sigma factor antagonist activity
CS527_RS08755	COG0477	Major facilitator Superfamily
CS527_RS08760	COG3858	chitin binding
CS527_RS08760	COG1388	LysM domain
CS527_RS08765	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_RS08770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CS527_RS08795	COG2226	methyltransferase
CS527_RS08810	COG1733	regulation of RNA biosynthetic process
CS527_RS08815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_RS08830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS08835	COG3420	alginic acid biosynthetic process
CS527_RS08855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CS527_RS08860	COG0640	Transcriptional regulator
CS527_RS08870	COG0640	Transcriptional regulator
CS527_RS08875	COG0346	lactoylglutathione lyase activity
CS527_RS08880	COG0475	glutathione-regulated potassium exporter activity
CS527_RS08880	COG0589	response to stress
CS527_RS08890	COG3011	Protein conserved in bacteria
CS527_RS08925	COG0583	DNA-binding transcription factor activity
CS527_RS08930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS527_RS08945	COG0753	catalase activity
CS527_RS08960	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS08965	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS08985	COG0384	phenazine biosynthesis protein PhzF
CS527_RS08995	COG5577	PFAM Coat F domain
CS527_RS09005	COG1063	alcohol dehydrogenase
CS527_RS09010	COG5577	PFAM Coat F domain
CS527_RS09025	COG0784	Response regulator, receiver
CS527_RS09025	COG2205	protein histidine kinase activity
CS527_RS09045	COG0673	inositol 2-dehydrogenase activity
CS527_RS09050	COG0673	inositol 2-dehydrogenase activity
CS527_RS09055	COG1082	Xylose isomerase domain protein TIM barrel
CS527_RS09060	COG2814	Major facilitator Superfamily
CS527_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS09085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS09100	COG0384	phenazine biosynthesis protein PhzF
CS527_RS09105	COG1694	Mazg nucleotide pyrophosphohydrolase
CS527_RS09125	COG0789	Transcriptional regulator
CS527_RS09130	COG1278	Cold shock
CS527_RS09190	COG1113	amino acid transport
CS527_RS09200	COG2207	Transcriptional regulator
CS527_RS09210	COG2376	Dihydroxyacetone kinase
CS527_RS09265	COG2323	membrane
CS527_RS09270	COG2323	membrane
CS527_RS09285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS527_RS09365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS09390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS527_RS09395	COG1587	Uroporphyrinogen-III synthase
CS527_RS09400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS09405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CS527_RS09415	COG3253	May function as heme-dependent peroxidase
CS527_RS09420	COG1982	Orn Lys Arg decarboxylase major
CS527_RS09435	COG1073	alpha beta
CS527_RS09450	COG3545	Serine hydrolase
CS527_RS09460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CS527_RS09470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS527_RS09485	COG1278	Cold shock
CS527_RS09495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS09500	COG0697	spore germination
CS527_RS09515	COG2226	methyltransferase
CS527_RS09520	COG0138	bifunctional purine biosynthesis protein purh
CS527_RS09525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS09530	COG1114	Component of the transport system for branched-chain amino acids
CS527_RS09540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CS527_RS09570	COG1017	nitric oxide dioxygenase activity
CS527_RS09570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CS527_RS09580	COG0574	Belongs to the PEP-utilizing enzyme family
CS527_RS09580	COG3848	Pyruvate phosphate dikinase
CS527_RS09585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CS527_RS09595	COG0477	Major facilitator Superfamily
CS527_RS09615	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS09650	COG0517	IMP dehydrogenase activity
CS527_RS09665	COG1309	transcriptional regulator
CS527_RS09680	COG1070	Carbohydrate kinase
CS527_RS09685	COG2814	Major facilitator Superfamily
CS527_RS09685	COG0477	Major facilitator Superfamily
CS527_RS09695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CS527_RS09700	COG1845	cytochrome c oxidase, subunit III
CS527_RS09710	COG0589	response to stress
CS527_RS09720	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS09725	COG1612	heme a metabolic process
CS527_RS09730	COG2072	flavoprotein involved in K transport
CS527_RS09740	COG2252	PERMEase
CS527_RS09750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CS527_RS09755	COG0022	dehydrogenase e1 component
CS527_RS09760	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_RS09765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS527_RS09770	COG3284	Transcriptional regulator
CS527_RS09775	COG1063	alcohol dehydrogenase
CS527_RS09785	COG1846	Transcriptional regulator
CS527_RS09795	COG2721	sulfolactate sulfo-lyase activity
CS527_RS09805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CS527_RS09810	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS09815	COG2271	Major facilitator Superfamily
CS527_RS09820	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_RS09825	COG2186	Transcriptional regulator
CS527_RS09845	COG0628	permease
CS527_RS09850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS527_RS09860	COG2211	Major facilitator Superfamily
CS527_RS09885	COG0589	response to stress
CS527_RS09890	COG5002	protein histidine kinase activity
CS527_RS09900	COG1937	Protein conserved in bacteria
CS527_RS09905	COG2608	mercury ion transmembrane transporter activity
CS527_RS09910	COG2217	Heavy metal translocating P-type atpase
CS527_RS09920	COG1388	LysM domain
CS527_RS09925	COG2271	Major facilitator Superfamily
CS527_RS09955	COG0640	Transcriptional regulator
CS527_RS09960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CS527_RS09965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS527_RS09975	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CS527_RS09980	COG2323	membrane
CS527_RS09995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CS527_RS10000	COG1802	Transcriptional regulator
CS527_RS10005	COG0473	3-isopropylmalate dehydrogenase activity
CS527_RS10010	COG2814	Major facilitator Superfamily
CS527_RS10015	COG1733	regulation of RNA biosynthetic process
CS527_RS10020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CS527_RS10020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CS527_RS10025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS527_RS10025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS527_RS10040	COG2226	methyltransferase
CS527_RS10050	COG5566	PFAM Mor transcription activator
CS527_RS10065	COG0561	phosphatase activity
CS527_RS10070	COG1876	peptidase activity
CS527_RS10115	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CS527_RS10130	COG0386	Belongs to the glutathione peroxidase family
CS527_RS10135	COG1418	mRNA catabolic process
CS527_RS10140	COG0488	(ABC) transporter
CS527_RS10145	COG1413	lyase activity
CS527_RS10150	COG0726	polysaccharide deacetylase
CS527_RS10160	COG2521	methyltransferase
CS527_RS10160	COG2136	Putative SAM-dependent methyltransferase
CS527_RS10170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_RS10175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_RS10185	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CS527_RS10190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CS527_RS10195	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CS527_RS10200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CS527_RS10205	COG0406	alpha-ribazole phosphatase activity
CS527_RS10215	COG2096	Adenosyltransferase
CS527_RS10220	COG2962	Rard protein
CS527_RS10230	COG0523	cobalamin synthesis protein
CS527_RS10235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CS527_RS10240	COG0322	excinuclease ABC activity
CS527_RS10250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS527_RS10255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS527_RS10260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS527_RS10265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CS527_RS10270	COG3011	Protein conserved in bacteria
CS527_RS10275	COG1595	DNA-templated transcription, initiation
CS527_RS10295	COG2002	toxin-antitoxin pair type II binding
CS527_RS10300	COG0534	Mate efflux family protein
CS527_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS10330	COG1368	sulfuric ester hydrolase activity
CS527_RS10340	COG3853	Toxic anion resistance protein (TelA)
CS527_RS10365	COG2234	aminopeptidase activity
CS527_RS10370	COG5002	protein histidine kinase activity
CS527_RS10380	COG1823	symporter activity
CS527_RS10385	COG1523	belongs to the glycosyl hydrolase 13 family
CS527_RS10390	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS10395	COG2124	cytochrome p450
CS527_RS10400	COG2112	serine threonine protein kinase
CS527_RS10410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CS527_RS10415	COG1360	Flagellar Motor Protein
CS527_RS10430	COG3361	conserved protein (COG2071)
CS527_RS10435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CS527_RS10440	COG1757	Na H antiporter
CS527_RS10450	COG0833	amino acid
CS527_RS10455	COG3594	Acyltransferase
CS527_RS10460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS527_RS10465	COG0745	RESPONSE REGULATOR receiver
CS527_RS10470	COG5002	protein histidine kinase activity
CS527_RS10475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CS527_RS10480	COG3104	oligopeptide transport
CS527_RS10490	COG0281	malic enzyme
CS527_RS10495	COG3493	citrate carrier protein
CS527_RS10500	COG0561	phosphatase activity
CS527_RS10510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS10520	COG0456	acetyltransferase
CS527_RS10525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CS527_RS10530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_RS10535	COG0765	amino acid transport
CS527_RS10540	COG0765	amino acid transport
CS527_RS10545	COG1126	abc transporter atp-binding protein
CS527_RS10550	COG0196	riboflavin kinase activity
CS527_RS10555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS10565	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_RS10605	COG1611	Belongs to the LOG family
CS527_RS10610	COG0281	malic enzyme
CS527_RS10615	COG3402	PFAM membrane-flanked domain
CS527_RS10620	COG3428	Bacterial PH domain
CS527_RS10635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_RS10640	COG0109	protoheme IX farnesyltransferase activity
CS527_RS10645	COG4195	phage-related replication protein
CS527_RS10655	COG0789	Transcriptional regulator
CS527_RS10690	COG0583	DNA-binding transcription factor activity
CS527_RS10695	COG0069	glutamate synthase activity
CS527_RS10695	COG0067	glutamate synthase
CS527_RS10695	COG0070	glutamate synthase
CS527_RS10700	COG0493	'glutamate synthase
CS527_RS10720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CS527_RS10735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_RS10750	COG1846	Transcriptional regulator
CS527_RS10755	COG1380	Effector of murein hydrolase LrgA
CS527_RS10760	COG1346	cytolysis
CS527_RS10765	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS10780	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CS527_RS10785	COG0463	Glycosyl transferase, family 2
CS527_RS10795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS527_RS10800	COG0745	RESPONSE REGULATOR receiver
CS527_RS10810	COG5583	Uncharacterized small protein (DUF2292)
CS527_RS10820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CS527_RS10830	COG4208	sulfate ABC transporter
CS527_RS10845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS10855	COG1349	DNA-binding transcription factor activity
CS527_RS10860	COG1105	Belongs to the carbohydrate kinase PfkB family
CS527_RS10865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CS527_RS10865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CS527_RS10865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_RS10870	COG0527	aspartate kinase activity
CS527_RS10880	COG2032	superoxide dismutase activity
CS527_RS10885	COG1233	COG1233 Phytoene dehydrogenase and related
CS527_RS10895	COG0300	oxidoreductase activity
CS527_RS10900	COG0640	Transcriptional regulator
CS527_RS10905	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS10910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CS527_RS10925	COG0733	neurotransmitter:sodium symporter activity
CS527_RS10935	COG3773	Cell wall hydrolase
CS527_RS10955	COG0673	inositol 2-dehydrogenase activity
CS527_RS10960	COG1082	Xylose isomerase domain protein TIM barrel
CS527_RS10965	COG2094	Belongs to the DNA glycosylase MPG family
CS527_RS10975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CS527_RS10985	COG0454	-acetyltransferase
CS527_RS10995	COG2814	Major facilitator Superfamily
CS527_RS11010	COG3871	stress protein (general stress protein 26)
CS527_RS11035	COG1595	DNA-templated transcription, initiation
CS527_RS11040	COG4873	Protein conserved in bacteria
CS527_RS11045	COG0714	Associated with various cellular activities
CS527_RS11050	COG4548	von Willebrand factor, type A
CS527_RS11055	COG0697	spore germination
CS527_RS11065	COG2207	Transcriptional regulator
CS527_RS11070	COG1994	Peptidase M50
CS527_RS11075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS11080	COG1119	ATPase activity
CS527_RS11095	COG1657	PFAM Prenyltransferase squalene oxidase
CS527_RS11105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CS527_RS11105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CS527_RS11115	COG0384	phenazine biosynthesis protein PhzF
CS527_RS11130	COG1378	Sugar-specific transcriptional regulator TrmB
CS527_RS11135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS527_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS11160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS11165	COG1279	arginine transmembrane transporter activity
CS527_RS11195	COG1396	sequence-specific DNA binding
CS527_RS11210	COG0494	nUDIX hydrolase
CS527_RS11215	COG1335	isochorismatase
CS527_RS11220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CS527_RS11225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CS527_RS11235	COG1098	S1 RNA binding domain
CS527_RS11240	COG1404	Belongs to the peptidase S8 family
CS527_RS11245	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS11250	COG1254	Belongs to the acylphosphatase family
CS527_RS11255	COG2223	nitrite transmembrane transporter activity
CS527_RS11260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS11270	COG0662	Cupin 2, conserved barrel domain protein
CS527_RS11270	COG2207	Transcriptional regulator
CS527_RS11275	COG0697	spore germination
CS527_RS11280	COG0488	(ABC) transporter
CS527_RS11285	COG0697	spore germination
CS527_RS11290	COG0531	amino acid
CS527_RS11305	COG1131	(ABC) transporter
CS527_RS11310	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CS527_RS11315	COG1757	Na H antiporter
CS527_RS11320	COG1609	Transcriptional regulator
CS527_RS11330	COG1533	DNA photolyase activity
CS527_RS11350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS527_RS11350	COG0551	DNA topoisomerase type I activity
CS527_RS11360	COG0446	pyridine nucleotide-disulphide oxidoreductase
CS527_RS11390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_RS11410	COG1757	Na H antiporter
CS527_RS11415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS527_RS11425	COG0697	spore germination
CS527_RS11435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS11445	COG2720	vancomycin resistance protein
CS527_RS11485	COG0514	ATP-dependent DNA helicase (RecQ)
CS527_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS11515	COG1575	Belongs to the MenA family. Type 1 subfamily
CS527_RS11520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CS527_RS11540	COG0583	DNA-binding transcription factor activity
CS527_RS11545	COG1725	Transcriptional regulator
CS527_RS11550	COG1131	(ABC) transporter
CS527_RS11560	COG1595	DNA-templated transcription, initiation
CS527_RS11575	COG1764	response to oxidative stress
CS527_RS11580	COG1846	Transcriptional regulator
CS527_RS11595	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CS527_RS11605	COG3584	3D domain protein
CS527_RS11605	COG1388	LysM domain
CS527_RS11625	COG5002	protein histidine kinase activity
CS527_RS11630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CS527_RS11635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CS527_RS11640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CS527_RS11655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CS527_RS11670	COG2409	Drug exporters of the RND superfamily
CS527_RS11675	COG1834	amidinotransferase
CS527_RS11685	COG1295	ribonuclease BN
CS527_RS11770	COG0110	maltose O-acetyltransferase activity
CS527_RS11775	COG0346	lactoylglutathione lyase activity
CS527_RS11785	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS11795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_RS11805	COG2176	DNA-directed DNA polymerase activity
CS527_RS11820	COG0114	fumarate hydratase activity
CS527_RS11830	COG3757	hydrolase, family 25
CS527_RS11830	COG3409	Peptidoglycan-binding domain 1 protein
CS527_RS11840	COG5002	protein histidine kinase activity
CS527_RS11880	COG0778	Nitroreductase
CS527_RS11890	COG0300	oxidoreductase activity
CS527_RS11895	COG3290	protein histidine kinase activity
CS527_RS11900	COG4565	transcriptional regulatory protein
CS527_RS11905	COG2851	Citrate transporter
CS527_RS11915	COG2610	gluconate transmembrane transporter activity
CS527_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS11925	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS527_RS11950	COG4122	O-methyltransferase activity
CS527_RS11955	COG0583	DNA-binding transcription factor activity
CS527_RS11965	COG1301	dicarboxylic acid transport
CS527_RS11970	COG0019	diaminopimelate decarboxylase activity
CS527_RS11990	COG4191	Histidine kinase
CS527_RS12010	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_RS12020	COG1250	3-hydroxyacyl-CoA dehydrogenase
CS527_RS12025	COG1024	Enoyl-CoA hydratase
CS527_RS12040	COG2045	Belongs to the ComB family
CS527_RS12045	COG1960	acyl-CoA dehydrogenase activity
CS527_RS12050	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS12055	COG1024	Enoyl-CoA hydratase
CS527_RS12070	COG1141	Ferredoxin
CS527_RS12080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS527_RS12090	COG0183	Belongs to the thiolase family
CS527_RS12095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS527_RS12100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CS527_RS12120	COG1509	lysine 2,3-aminomutase activity
CS527_RS12130	COG0833	amino acid
CS527_RS12135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_RS12150	COG1979	alcohol dehydrogenase
CS527_RS12155	COG0738	Major facilitator superfamily
CS527_RS12160	COG1181	Belongs to the D-alanine--D-alanine ligase family
CS527_RS12180	COG3977	Valine--pyruvate aminotransferase
CS527_RS12185	COG3773	Cell wall hydrolase
CS527_RS12200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CS527_RS12210	COG0531	amino acid
CS527_RS12215	COG2814	Major facilitator Superfamily
CS527_RS12220	COG1846	Transcriptional regulator
CS527_RS12225	COG2409	Drug exporters of the RND superfamily
CS527_RS12225	COG1033	growth of symbiont in host cell
CS527_RS12230	COG3842	ATPase activity
CS527_RS12235	COG2222	sugar isomerase
CS527_RS12240	COG1653	transport
CS527_RS12245	COG1175	transmembrane transport
CS527_RS12250	COG0395	ABC-type sugar transport system, permease component
CS527_RS12255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_RS12260	COG2188	Transcriptional regulator
CS527_RS12265	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS12265	COG2202	Pas domain
CS527_RS12270	COG3832	glyoxalase III activity
CS527_RS12275	COG0640	Transcriptional regulator
CS527_RS12285	COG2267	carboxylic ester hydrolase activity
CS527_RS12295	COG3386	PFAM SMP-30 Gluconolaconase
CS527_RS12305	COG2368	4-hydroxyphenylacetate
CS527_RS12310	COG3739	integral membrane protein
CS527_RS12320	COG0326	Molecular chaperone. Has ATPase activity
CS527_RS12325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CS527_RS12345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CS527_RS12350	COG3757	hydrolase, family 25
CS527_RS12350	COG3409	Peptidoglycan-binding domain 1 protein
CS527_RS12360	COG0697	spore germination
CS527_RS12365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS12380	COG4572	Cation transport regulator
CS527_RS12385	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CS527_RS12390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS527_RS12405	COG3011	Protein conserved in bacteria
CS527_RS12410	COG1136	(ABC) transporter
CS527_RS12470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_RS12485	COG0494	nUDIX hydrolase
CS527_RS12490	COG0702	epimerase
CS527_RS12495	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_RS12500	COG1846	Transcriptional regulator
CS527_RS12505	COG2720	vancomycin resistance protein
CS527_RS12510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CS527_RS12535	COG0076	glutamate decarboxylase activity
CS527_RS12565	COG2116	formate transmembrane transporter activity
CS527_RS12570	COG5609	conserved protein (DUF2294)
CS527_RS12585	COG2271	Major facilitator Superfamily
CS527_RS12590	COG0277	FAD linked oxidase domain protein
CS527_RS12595	COG0840	transmembrane signaling receptor activity
CS527_RS12605	COG0622	Phosphoesterase
CS527_RS12615	COG1408	metallophosphoesterase
CS527_RS12620	COG3663	DNA glycosylase
CS527_RS12625	COG3883	PFAM NLP P60 protein
CS527_RS12625	COG0791	NLP P60 protein
CS527_RS12630	COG1587	Uroporphyrinogen-III synthase
CS527_RS12635	COG1414	Transcriptional regulator
CS527_RS12640	COG0439	Biotin carboxylase
CS527_RS12645	COG0511	ligase activity, forming carbon-carbon bonds
CS527_RS12650	COG1984	allophanate hydrolase subunit 2
CS527_RS12655	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CS527_RS12660	COG4336	lyase activity
CS527_RS12665	COG1914	H( )-stimulated, divalent metal cation uptake system
CS527_RS12670	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CS527_RS12685	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_RS12690	COG1268	BioY protein
CS527_RS12695	COG0183	Belongs to the thiolase family
CS527_RS12715	COG0431	NADPH-dependent FMN reductase
CS527_RS12720	COG2197	response regulator
CS527_RS12725	COG2203	Gaf domain
CS527_RS12725	COG4585	Histidine kinase
CS527_RS12745	COG0697	spore germination
CS527_RS12755	COG2153	protein acetylation
CS527_RS12760	COG0129	dihydroxy-acid dehydratase activity
CS527_RS12765	COG2267	carboxylic ester hydrolase activity
CS527_RS12770	COG1227	inorganic diphosphatase activity
CS527_RS12790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS527_RS12800	COG0204	Acyl-transferase
CS527_RS12805	COG2233	PERMEase
CS527_RS12810	COG3195	allantoin biosynthetic process
CS527_RS12810	COG3648	Uricase
CS527_RS12835	COG1914	H( )-stimulated, divalent metal cation uptake system
CS527_RS12850	COG1011	Hydrolase
CS527_RS12855	COG1846	Transcriptional regulator
CS527_RS12865	COG4974	Belongs to the 'phage' integrase family
CS527_RS12885	COG0531	amino acid
CS527_RS12890	COG4302	ethanolamine ammonia-lyase activity
CS527_RS12895	COG4303	Ethanolamine ammonia lyase large subunit
CS527_RS12900	COG4819	ethanolamine utilization protein
CS527_RS12910	COG0833	amino acid
CS527_RS12920	COG1247	-acetyltransferase
CS527_RS12925	COG1335	isochorismatase
CS527_RS12935	COG3403	YqcI/YcgG family
CS527_RS12940	COG1280	lysine exporter protein (LysE YggA)
CS527_RS12945	COG2267	carboxylic ester hydrolase activity
CS527_RS12950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CS527_RS12955	COG0187	DNA topoisomerase II activity
CS527_RS12960	COG1832	CoA-binding protein
CS527_RS12965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CS527_RS12970	COG4841	protein insertion into membrane
CS527_RS12975	COG0824	Thioesterase
CS527_RS13005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_RS13010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CS527_RS13030	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CS527_RS13065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CS527_RS13070	COG2068	MobA-Related Protein
CS527_RS13075	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CS527_RS13130	COG1183	phosphatidylcholine synthase activity
CS527_RS13145	COG2814	Major facilitator Superfamily
CS527_RS13150	COG1683	Conserved Protein
CS527_RS13155	COG1302	Protein conserved in bacteria
CS527_RS13170	COG1295	ribonuclease BN
CS527_RS13180	COG1115	amino acid carrier protein
CS527_RS13185	COG2814	Major facilitator Superfamily
CS527_RS13200	COG0789	Transcriptional regulator
CS527_RS13210	COG0288	reversible hydration of carbon dioxide
CS527_RS13215	COG0659	secondary active sulfate transmembrane transporter activity
CS527_RS13220	COG0745	RESPONSE REGULATOR receiver
CS527_RS13225	COG5002	protein histidine kinase activity
CS527_RS13235	COG0477	Major facilitator Superfamily
CS527_RS13240	COG4282	regulation of fungal-type cell wall biogenesis
CS527_RS13245	COG0531	amino acid
CS527_RS13255	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_RS13260	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CS527_RS13330	COG1363	Peptidase, m42
CS527_RS13340	COG1114	Component of the transport system for branched-chain amino acids
CS527_RS13360	COG0004	ammonium transporteR
CS527_RS13375	COG1252	NADH dehydrogenase
CS527_RS13380	COG0679	Auxin Efflux Carrier
CS527_RS13385	COG0281	malic enzyme
CS527_RS13390	COG1473	amidohydrolase
CS527_RS13395	COG2271	Major facilitator Superfamily
CS527_RS13415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CS527_RS13420	COG0163	prenyltransferase activity
CS527_RS13425	COG0583	DNA-binding transcription factor activity
CS527_RS13430	COG0679	Auxin Efflux Carrier
CS527_RS13450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS13455	COG0247	lactate metabolic process
CS527_RS13460	COG0277	FAD linked oxidase domain protein
CS527_RS13465	COG3835	regulator
CS527_RS13470	COG0693	protein deglycase activity
CS527_RS13480	COG2610	gluconate transmembrane transporter activity
CS527_RS13500	COG1131	(ABC) transporter
CS527_RS13510	COG2197	response regulator
CS527_RS13545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS13555	COG0586	Pfam SNARE associated Golgi protein
CS527_RS13560	COG1515	deoxyribonuclease V activity
CS527_RS13565	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_RS13570	COG3153	acetyltransferase
CS527_RS13570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_RS13580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_RS13585	COG0531	amino acid
CS527_RS13720	COG0534	Mate efflux family protein
CS527_RS13725	COG1566	PFAM secretion protein HlyD family protein
CS527_RS13735	COG1846	Transcriptional regulator
CS527_RS13740	COG0708	Exodeoxyribonuclease III
CS527_RS13755	COG0673	inositol 2-dehydrogenase activity
CS527_RS13760	COG1349	DNA-binding transcription factor activity
CS527_RS13765	COG3853	Toxic anion resistance protein (TelA)
CS527_RS13775	COG2310	stress, protein
CS527_RS13780	COG2310	stress, protein
CS527_RS13785	COG2310	stress, protein
CS527_RS13790	COG0737	Belongs to the 5'-nucleotidase family
CS527_RS13810	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CS527_RS13815	COG1131	(ABC) transporter
CS527_RS13825	COG2084	Dehydrogenase
CS527_RS13830	COG1278	Cold shock
CS527_RS13835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS13845	COG0028	Belongs to the TPP enzyme family
CS527_RS13850	COG1278	Cold shock
CS527_RS13875	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS13890	COG0427	acetyl-CoA hydrolase
CS527_RS13895	COG3279	Response regulator of the LytR AlgR family
CS527_RS13900	COG2323	membrane
CS527_RS13905	COG2814	Major facilitator Superfamily
CS527_RS13910	COG1388	LysM domain
CS527_RS13910	COG3584	3D domain protein
CS527_RS13915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CS527_RS13940	COG3340	Belongs to the peptidase S51 family
CS527_RS13965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CS527_RS13995	COG2318	DinB family
CS527_RS14005	COG0579	oxidoreductase
CS527_RS14035	COG0488	(ABC) transporter
CS527_RS14040	COG1486	melibiose metabolic process
CS527_RS14045	COG0395	ABC-type sugar transport system, permease component
CS527_RS14050	COG1175	transmembrane transport
CS527_RS14055	COG1653	transport
CS527_RS14060	COG1609	Transcriptional regulator
CS527_RS14070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS527_RS14090	COG1929	Belongs to the glycerate kinase type-1 family
CS527_RS14095	COG2610	gluconate transmembrane transporter activity
CS527_RS14100	COG3835	regulator
CS527_RS14105	COG1454	alcohol dehydrogenase
CS527_RS14110	COG3152	Membrane
CS527_RS14125	COG0492	ferredoxin-NADP+ reductase activity
CS527_RS14140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_RS14145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS14150	COG3152	Membrane
CS527_RS14170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CS527_RS14180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CS527_RS14195	COG2390	Transcriptional regulator
CS527_RS14225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CS527_RS14235	COG1695	Transcriptional regulator
CS527_RS14240	COG0501	Belongs to the peptidase M48B family
CS527_RS14245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_RS14250	COG1742	UPF0060 membrane protein
CS527_RS14255	COG2182	Extracellular solute-binding protein
CS527_RS14275	COG2031	fatty acid transporter
CS527_RS14305	COG2391	methyltransferase activity
CS527_RS14320	COG1979	alcohol dehydrogenase
CS527_RS14325	COG0583	DNA-binding transcription factor activity
CS527_RS14340	COG2211	Major facilitator Superfamily
CS527_RS14370	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS14375	COG1063	alcohol dehydrogenase
CS527_RS14400	COG0025	NhaP-type Na H and K H
CS527_RS14405	COG1253	flavin adenine dinucleotide binding
CS527_RS14430	COG4608	Belongs to the ABC transporter superfamily
CS527_RS14440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS527_RS14445	COG0601	transmembrane transport
CS527_RS14450	COG0747	negative chemotaxis
CS527_RS14460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS14480	COG1525	nuclease
CS527_RS14490	COG0579	oxidoreductase
CS527_RS14495	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CS527_RS14500	COG0561	phosphatase activity
CS527_RS14515	COG0668	transmembrane transport
CS527_RS14545	COG2309	aminopeptidase activity
CS527_RS14550	COG1414	Transcriptional regulator
CS527_RS14555	COG0179	Fumarylacetoacetate (FAA) hydrolase
CS527_RS14560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CS527_RS14565	COG0277	FAD linked oxidase domain protein
CS527_RS14570	COG0247	lactate metabolic process
CS527_RS14575	COG0277	FAD linked oxidase domain protein
CS527_RS14580	COG1620	l-lactate permease
CS527_RS14600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CS527_RS14605	COG1131	(ABC) transporter
CS527_RS14625	COG1595	DNA-templated transcription, initiation
CS527_RS14645	COG4682	membrane
CS527_RS14660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS14665	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS14670	COG0598	Magnesium transport protein CorA
CS527_RS14675	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CS527_RS14685	COG2323	membrane
CS527_RS14690	COG1876	peptidase activity
CS527_RS14705	COG5002	protein histidine kinase activity
CS527_RS14710	COG0745	RESPONSE REGULATOR receiver
CS527_RS14730	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_RS14745	COG2814	Major facilitator Superfamily
CS527_RS14750	COG1764	response to oxidative stress
CS527_RS14760	COG2311	Membrane
CS527_RS14820	COG0347	Belongs to the P(II) protein family
CS527_RS14825	COG0004	ammonium transporteR
CS527_RS14830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CS527_RS14845	COG0596	Alpha beta hydrolase
CS527_RS14865	COG0456	acetyltransferase
CS527_RS14865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CS527_RS14870	COG1960	acyl-CoA dehydrogenase activity
CS527_RS14910	COG4604	ABC transporter, ATP-binding protein
CS527_RS14915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_RS14920	COG1492	cobalamin metabolic process
CS527_RS14930	COG0531	amino acid
CS527_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS14945	COG2404	hydrolase activity, acting on ester bonds
CS527_RS14950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CS527_RS14960	COG1609	Transcriptional regulator
CS527_RS14970	COG2271	Major facilitator Superfamily
CS527_RS14975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_RS14990	COG1233	COG1233 Phytoene dehydrogenase and related
CS527_RS14995	COG0463	Glycosyl transferase, family 2
CS527_RS15040	COG0804	urea catabolic process
CS527_RS15050	COG0831	urea catabolic process
CS527_RS15055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CS527_RS15060	COG1388	LysM domain
CS527_RS15060	COG0791	NLP P60 protein
CS527_RS15065	COG1388	LysM domain
CS527_RS15065	COG3584	3D domain protein
CS527_RS15065	COG1388	LysM domain
CS527_RS15065	COG3584	3D domain protein
CS527_RS15070	COG0778	Nitroreductase
CS527_RS15075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CS527_RS15080	COG0586	Pfam SNARE associated Golgi protein
CS527_RS15090	COG0400	carboxylic ester hydrolase activity
CS527_RS15095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS527_RS15100	COG2244	polysaccharide biosynthetic process
CS527_RS15105	COG0697	spore germination
CS527_RS15110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS15130	COG1132	(ABC) transporter
CS527_RS15155	COG4195	phage-related replication protein
CS527_RS15165	COG0783	Belongs to the Dps family
CS527_RS15175	COG5577	PFAM Coat F domain
CS527_RS15180	COG1253	flavin adenine dinucleotide binding
CS527_RS15195	COG0516	GMP reductase activity
CS527_RS15195	COG0517	IMP dehydrogenase activity
CS527_RS15205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS527_RS15205	COG0723	plastoquinol--plastocyanin reductase activity
CS527_RS15220	COG0287	Prephenate dehydrogenase
CS527_RS15230	COG1605	Chorismate mutase
CS527_RS15230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CS527_RS15240	COG2059	Chromate
CS527_RS15245	COG2059	Chromate
CS527_RS15255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CS527_RS15260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS527_RS15265	COG2508	Transcriptional regulator
CS527_RS15270	COG0011	TIGRFAM Protein of
CS527_RS15275	COG1388	LysM domain
CS527_RS15275	COG0791	NLP P60 protein
CS527_RS15280	COG0753	catalase activity
CS527_RS15290	COG0733	neurotransmitter:sodium symporter activity
CS527_RS15330	COG0730	response to heat
CS527_RS15335	COG1902	pentaerythritol trinitrate reductase activity
CS527_RS15350	COG2205	protein histidine kinase activity
CS527_RS15385	COG0640	Transcriptional regulator
CS527_RS15395	COG0778	Nitroreductase
CS527_RS15410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CS527_RS15415	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_RS15415	COG3103	Sh3 type 3 domain protein
CS527_RS15415	COG4991	sh3 domain protein
CS527_RS15420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CS527_RS15425	COG2002	toxin-antitoxin pair type II binding
CS527_RS15430	COG2318	DinB family
CS527_RS15435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS527_RS15445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CS527_RS15450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS15465	COG2211	Major facilitator Superfamily
CS527_RS15470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS15475	COG1597	lipid kinase activity
CS527_RS15485	COG0372	Belongs to the citrate synthase family
CS527_RS15490	COG0583	DNA-binding transcription factor activity
CS527_RS15495	COG0697	spore germination
CS527_RS15500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS15520	COG2202	Pas domain
CS527_RS15520	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS15525	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS15555	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS15560	COG2261	transglycosylase associated protein
CS527_RS15570	COG0740	serine-type endopeptidase activity
CS527_RS15585	COG1027	Aspartate ammonia-lyase
CS527_RS15590	COG0252	asparaginase activity
CS527_RS15595	COG1396	sequence-specific DNA binding
CS527_RS15610	COG0640	Transcriptional regulator
CS527_RS15630	COG0531	amino acid
CS527_RS15635	COG1959	2 iron, 2 sulfur cluster binding
CS527_RS15655	COG0281	malic enzyme
CS527_RS15660	COG2746	aminoglycoside 3-N-acetyltransferase activity
CS527_RS15670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS15675	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS15685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS527_RS15690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CS527_RS15700	COG0477	Major facilitator Superfamily
CS527_RS15705	COG1846	Transcriptional regulator
CS527_RS15710	COG0789	Transcriptional regulator
CS527_RS15715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS15750	COG1819	glycosyl
CS527_RS15765	COG1902	pentaerythritol trinitrate reductase activity
CS527_RS15775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CS527_RS15790	COG2814	Major facilitator Superfamily
CS527_RS15800	COG1228	amidohydrolase
CS527_RS15810	COG1316	TRANSCRIPTIONal
CS527_RS15815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS15835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CS527_RS15845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CS527_RS15915	COG1280	lysine exporter protein (LysE YggA)
CS527_RS15925	COG0531	amino acid
CS527_RS15940	COG3764	Sortase (surface protein transpeptidase)
CS527_RS15945	COG0730	response to heat
CS527_RS15950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS15955	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CS527_RS15965	COG2130	NADP-dependent
CS527_RS15990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS16005	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CS527_RS16015	COG0501	Belongs to the peptidase M48B family
CS527_RS16050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CS527_RS16050	COG0131	Imidazoleglycerol-phosphate dehydratase
CS527_RS16065	COG2076	Multidrug Resistance protein
CS527_RS16070	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CS527_RS16075	COG1278	Cold shock
CS527_RS16080	COG2323	membrane
CS527_RS16090	COG2910	NAD(P)H-binding
CS527_RS16120	COG3546	catalase activity
CS527_RS16125	COG4607	ABC-type enterochelin transport system periplasmic component
CS527_RS16130	COG4604	ABC transporter, ATP-binding protein
CS527_RS16135	COG4605	iron ion homeostasis
CS527_RS16140	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_RS16145	COG3773	Cell wall hydrolase
CS527_RS16165	COG1063	alcohol dehydrogenase
CS527_RS16170	COG3775	system Galactitol-specific IIC component
CS527_RS16175	COG3414	Phosphotransferase system galactitol-specific IIB component
CS527_RS16180	COG3414	Phosphotransferase system galactitol-specific IIB component
CS527_RS16195	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS527_RS16220	COG1349	DNA-binding transcription factor activity
CS527_RS16225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CS527_RS16235	COG1193	negative regulation of DNA recombination
CS527_RS16245	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CS527_RS16250	COG1396	sequence-specific DNA binding
CS527_RS16255	COG0861	Integral membrane protein TerC family
CS527_RS16260	COG1609	Transcriptional regulator
CS527_RS16265	COG1959	2 iron, 2 sulfur cluster binding
CS527_RS16325	COG3773	Cell wall hydrolase
CS527_RS16330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CS527_RS16360	COG3546	catalase activity
CS527_RS16380	COG1280	lysine exporter protein (LysE YggA)
CS527_RS16385	COG1917	Cupin 2, conserved barrel domain protein
CS527_RS16385	COG2207	Transcriptional regulator
CS527_RS16390	COG4585	Histidine kinase
CS527_RS16400	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_RS16415	COG3209	COG3209 Rhs family protein
CS527_RS16455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CS527_RS16465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CS527_RS16485	COG0346	lactoylglutathione lyase activity
CS527_RS16490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CS527_RS16505	COG1136	(ABC) transporter
CS527_RS16510	COG0577	efflux transmembrane transporter activity
CS527_RS16515	COG3850	Histidine kinase
CS527_RS16515	COG5002	protein histidine kinase activity
CS527_RS16540	COG5002	protein histidine kinase activity
CS527_RS16545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS16550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS527_RS16575	COG4989	oxidoreductase activity
CS527_RS16585	COG0697	spore germination
CS527_RS16590	COG1917	Cupin 2, conserved barrel domain protein
CS527_RS16590	COG2207	Transcriptional regulator
CS527_RS16665	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CS527_RS16675	COG1301	dicarboxylic acid transport
CS527_RS16680	COG2824	Alkylphosphonate utilization operon protein PhnA
CS527_RS16710	COG0405	Gamma-glutamyltransferase
CS527_RS16715	COG1073	alpha beta
CS527_RS16730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS527_RS16735	COG4521	taurine ABC transporter
CS527_RS16740	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CS527_RS16745	COG2175	clavaminate synthase activity
CS527_RS16750	COG2814	Major facilitator Superfamily
CS527_RS16770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS16780	COG1960	acyl-CoA dehydrogenase activity
CS527_RS16785	COG1063	alcohol dehydrogenase
CS527_RS16790	COG0745	RESPONSE REGULATOR receiver
CS527_RS16795	COG0642	Histidine kinase
CS527_RS16800	COG1136	(ABC) transporter
CS527_RS16805	COG0577	efflux transmembrane transporter activity
CS527_RS16815	COG0412	Dienelactone hydrolase
CS527_RS16820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS16835	COG0730	response to heat
CS527_RS16840	COG0425	Belongs to the sulfur carrier protein TusA family
CS527_RS16845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS527_RS16845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_RS16850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS527_RS16850	COG0425	Belongs to the sulfur carrier protein TusA family
CS527_RS16860	COG2210	Belongs to the sulfur carrier protein TusA family
CS527_RS16865	COG0425	Belongs to the sulfur carrier protein TusA family
CS527_RS16870	COG1937	Protein conserved in bacteria
CS527_RS16890	COG0583	DNA-binding transcription factor activity
CS527_RS16905	COG2188	Transcriptional regulator
CS527_RS16915	COG2723	6-phospho-beta-galactosidase activity
CS527_RS16940	COG1280	lysine exporter protein (LysE YggA)
CS527_RS16955	COG0583	DNA-binding transcription factor activity
CS527_RS16960	COG2814	Major facilitator Superfamily
CS527_RS16965	COG0346	lactoylglutathione lyase activity
CS527_RS16990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CS527_RS17005	COG0778	Nitroreductase
CS527_RS17010	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS17030	COG1704	LemA family
CS527_RS17035	COG0726	polysaccharide deacetylase
CS527_RS17050	COG1733	regulation of RNA biosynthetic process
CS527_RS17055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS527_RS17060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS527_RS17065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_RS17080	COG2304	oxidoreductase activity
CS527_RS17090	COG0346	lactoylglutathione lyase activity
CS527_RS17095	COG2808	Putative FMN-binding domain
CS527_RS17130	COG4807	Protein conserved in bacteria
CS527_RS17140	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CS527_RS17145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS17150	COG1278	Cold shock
CS527_RS17155	COG1278	Cold shock
CS527_RS17170	COG0747	negative chemotaxis
CS527_RS17175	COG0601	transmembrane transport
CS527_RS17180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS527_RS17185	COG0444	Belongs to the ABC transporter superfamily
CS527_RS17190	COG4608	Belongs to the ABC transporter superfamily
CS527_RS17200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CS527_RS17205	COG1301	dicarboxylic acid transport
CS527_RS17220	COG0477	Major facilitator Superfamily
CS527_RS17265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_RS17270	COG0659	secondary active sulfate transmembrane transporter activity
CS527_RS17280	COG2211	Major facilitator Superfamily
CS527_RS17285	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CS527_RS17290	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CS527_RS17295	COG1691	(AIR) carboxylase
CS527_RS17300	COG1606	tRNA processing
CS527_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS17315	COG1904	glucuronate isomerase
CS527_RS17365	COG0561	phosphatase activity
CS527_RS17375	COG2312	Erythromycin esterase
CS527_RS17390	COG2329	Antibiotic biosynthesis monooxygenase
CS527_RS17430	COG3655	Transcriptional regulator
CS527_RS17440	COG0583	DNA-binding transcription factor activity
CS527_RS17445	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS17460	COG1609	Transcriptional regulator
CS527_RS17465	COG1082	Xylose isomerase domain protein TIM barrel
CS527_RS17470	COG0673	inositol 2-dehydrogenase activity
CS527_RS17490	COG3718	enzyme involved in inositol metabolism
CS527_RS17495	COG3962	Belongs to the TPP enzyme family
CS527_RS17500	COG1349	DNA-binding transcription factor activity
CS527_RS17505	COG0191	fructose-bisphosphate aldolase activity
CS527_RS17510	COG1082	Xylose isomerase domain protein TIM barrel
CS527_RS17515	COG2814	Major facilitator Superfamily
CS527_RS17530	COG1064	alcohol dehydrogenase
CS527_RS17535	COG0789	Transcriptional regulator
CS527_RS17550	COG0662	Cupin 2, conserved barrel domain protein
CS527_RS17570	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS17575	COG1278	Cold shock
CS527_RS17590	COG1876	peptidase activity
CS527_RS17610	COG0598	Magnesium transport protein CorA
CS527_RS17615	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_RS17625	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS17635	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS17650	COG4335	DNA alkylation repair
CS527_RS17655	COG0454	-acetyltransferase
CS527_RS17675	COG2814	Major facilitator Superfamily
CS527_RS17680	COG0574	Belongs to the PEP-utilizing enzyme family
CS527_RS17680	COG3848	Pyruvate phosphate dikinase
CS527_RS17685	COG0574	Belongs to the PEP-utilizing enzyme family
CS527_RS17685	COG3848	Pyruvate phosphate dikinase
CS527_RS17700	COG2186	Transcriptional regulator
CS527_RS17720	COG3619	membrane
CS527_RS17730	COG1349	DNA-binding transcription factor activity
CS527_RS17735	COG0561	phosphatase activity
CS527_RS17745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS527_RS17760	COG1280	lysine exporter protein (LysE YggA)
CS527_RS17785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CS527_RS17800	COG2814	Major facilitator Superfamily
CS527_RS17805	COG2160	L-arabinose isomerase activity
CS527_RS17820	COG1609	Transcriptional regulator
CS527_RS17825	COG1078	dGTPase activity
CS527_RS17845	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS527_RS17850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS527_RS17855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS527_RS17855	COG1918	ferrous iron import across plasma membrane
CS527_RS17880	COG1846	Transcriptional regulator
CS527_RS17915	COG0697	spore germination
CS527_RS17920	COG0791	NLP P60 protein
CS527_RS17920	COG1388	LysM domain
CS527_RS17925	COG2258	MOSC domain
CS527_RS17930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CS527_RS17965	COG4974	Belongs to the 'phage' integrase family
CS527_RS18005	COG1309	transcriptional regulator
CS527_RS18010	COG3844	kynureninase activity
CS527_RS18015	COG1113	amino acid transport
CS527_RS18020	COG3483	tryptophan 2,3-dioxygenase activity
CS527_RS18025	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CS527_RS18030	COG1942	4-Oxalocrotonate Tautomerase
CS527_RS18060	COG0251	oxidation-reduction process
CS527_RS18075	COG0431	NADPH-dependent FMN reductase
CS527_RS18080	COG0196	riboflavin kinase activity
CS527_RS18085	COG2368	4-hydroxyphenylacetate
CS527_RS18105	COG0789	Transcriptional regulator
CS527_RS18140	COG5646	InterPro IPR014922
CS527_RS18175	COG2814	Major facilitator Superfamily
CS527_RS18185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CS527_RS18195	COG2258	MOSC domain
CS527_RS18210	COG0477	Major facilitator Superfamily
CS527_RS18215	COG0583	DNA-binding transcription factor activity
CS527_RS18220	COG2070	2-Nitropropane dioxygenase
CS527_RS18225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CS527_RS18250	COG2271	Major facilitator Superfamily
CS527_RS18255	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_RS18265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_RS18270	COG1414	Transcriptional regulator
CS527_RS18280	COG1476	TRANSCRIPTIONal
CS527_RS18315	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS18320	COG2188	Transcriptional regulator
CS527_RS18330	COG1501	Belongs to the glycosyl hydrolase 31 family
CS527_RS18340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CS527_RS18350	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CS527_RS18360	COG0300	oxidoreductase activity
CS527_RS18370	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_RS18370	COG0596	Alpha beta hydrolase
CS527_RS18375	COG1309	transcriptional regulator
CS527_RS18380	COG1733	regulation of RNA biosynthetic process
CS527_RS18385	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS527_RS18390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS527_RS18395	COG2226	methyltransferase
CS527_RS18410	COG1942	4-Oxalocrotonate Tautomerase
CS527_RS18415	COG0583	DNA-binding transcription factor activity
CS527_RS18420	COG0047	phosphoribosylformylglycinamidine synthase activity
CS527_RS18425	COG1522	sequence-specific DNA binding
CS527_RS18435	COG2267	carboxylic ester hydrolase activity
CS527_RS18445	COG1335	isochorismatase
CS527_RS18455	COG0346	lactoylglutathione lyase activity
CS527_RS18460	COG2259	Doxx family
CS527_RS18465	COG0039	L-malate dehydrogenase activity
CS527_RS18470	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CS527_RS18475	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CS527_RS18495	COG1454	alcohol dehydrogenase
CS527_RS18495	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS18505	COG4302	ethanolamine ammonia-lyase activity
CS527_RS18510	COG4303	Ethanolamine ammonia lyase large subunit
CS527_RS18520	COG4917	ethanolamine utilization protein
CS527_RS18530	COG3192	ethanolamine utilization protein
CS527_RS18560	COG1309	transcriptional regulator
CS527_RS18565	COG2076	Multidrug Resistance protein
CS527_RS18575	COG0477	Major facilitator Superfamily
CS527_RS18580	COG1609	Transcriptional regulator
CS527_RS18585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CS527_RS18605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CS527_RS18615	COG2851	Citrate transporter
CS527_RS18625	COG0477	Major facilitator Superfamily
CS527_RS18635	COG0477	Major facilitator Superfamily
CS527_RS18640	COG1309	transcriptional regulator
CS527_RS18660	COG2318	DinB family
CS527_RS18665	COG0156	8-amino-7-oxononanoate synthase activity
CS527_RS18670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CS527_RS18685	COG1378	Sugar-specific transcriptional regulator TrmB
CS527_RS18690	COG0697	spore germination
CS527_RS18700	COG0583	DNA-binding transcription factor activity
CS527_RS18740	COG1266	CAAX protease self-immunity
CS527_RS18760	COG0252	asparaginase activity
CS527_RS18780	COG1695	Transcriptional regulator
CS527_RS18785	COG0656	L-ascorbic acid biosynthetic process
CS527_RS18795	COG0583	DNA-binding transcription factor activity
CS527_RS18805	COG2814	Major facilitator Superfamily
CS527_RS18815	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CS527_RS18825	COG0281	malic enzyme
CS527_RS18830	COG2404	hydrolase activity, acting on ester bonds
CS527_RS18890	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CS527_RS18960	COG3339	Conserved Protein
CS527_RS18975	COG2207	Transcriptional regulator
CS527_RS18975	COG3708	Transcriptional regulator
CS527_RS18990	COG1357	PFAM Pentapeptide repeats (8 copies)
CS527_RS19000	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS527_RS19005	COG1733	regulation of RNA biosynthetic process
CS527_RS19035	COG0303	'Molybdopterin
CS527_RS19045	COG0521	Mo-molybdopterin cofactor biosynthetic process
CS527_RS19050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CS527_RS19055	COG1079	Belongs to the binding-protein-dependent transport system permease family
CS527_RS19060	COG4603	Belongs to the binding-protein-dependent transport system permease family
CS527_RS19065	COG3845	ABC transporter
CS527_RS19080	COG2244	polysaccharide biosynthetic process
CS527_RS19100	COG2828	Protein conserved in bacteria
CS527_RS19105	COG0583	DNA-binding transcription factor activity
CS527_RS19110	COG2851	Citrate transporter
CS527_RS19125	COG0670	Belongs to the BI1 family
CS527_RS19145	COG0791	NLP P60 protein
CS527_RS19150	COG2814	Major facilitator Superfamily
CS527_RS19155	COG1846	Transcriptional regulator
CS527_RS19175	COG1278	Cold shock
CS527_RS19190	COG1113	amino acid transport
CS527_RS19195	COG1113	amino acid transport
CS527_RS19200	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS19205	COG0506	proline dehydrogenase activity
CS527_RS19210	COG3878	Protein conserved in bacteria
CS527_RS19225	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_RS19230	COG3300	MHYT domain
CS527_RS19230	COG5001	Diguanylate cyclase
CS527_RS19280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CS527_RS19285	COG5609	conserved protein (DUF2294)
CS527_RS19295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CS527_RS19320	COG0454	-acetyltransferase
CS527_RS19335	COG0789	Transcriptional regulator
CS527_RS19340	COG0667	Aldo Keto reductase
CS527_RS19350	COG0789	Transcriptional regulator
CS527_RS19375	COG1621	beta-fructofuranosidase activity
CS527_RS19380	COG4980	gas vesicle protein
CS527_RS19405	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS527_RS19410	COG0577	efflux transmembrane transporter activity
CS527_RS19415	COG1136	(ABC) transporter
CS527_RS19425	COG0642	Histidine kinase
CS527_RS19440	COG1289	transmembrane transporter activity
CS527_RS19445	COG1937	Protein conserved in bacteria
CS527_RS19450	COG3209	COG3209 Rhs family protein
CS527_RS19460	COG3973	AAA domain
CS527_RS19465	COG1024	Enoyl-CoA hydratase
CS527_RS19470	COG1733	regulation of RNA biosynthetic process
CS527_RS19485	COG2124	cytochrome p450
CS527_RS19490	COG2259	Doxx family
CS527_RS19495	COG0463	Glycosyl transferase, family 2
CS527_RS19505	COG0463	Glycosyl transferase, family 2
CS527_RS19520	COG1388	LysM domain
CS527_RS19520	COG0791	NLP P60 protein
CS527_RS19525	COG0840	transmembrane signaling receptor activity
CS527_RS19530	COG1846	Transcriptional regulator
CS527_RS19540	COG1595	DNA-templated transcription, initiation
CS527_RS19545	COG0726	polysaccharide deacetylase
CS527_RS19565	COG0833	amino acid
CS527_RS19575	COG0405	Gamma-glutamyltransferase
CS527_RS19595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CS527_RS19600	COG0569	domain protein
CS527_RS19610	COG1522	sequence-specific DNA binding
CS527_RS19620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS527_RS19625	COG0745	RESPONSE REGULATOR receiver
CS527_RS19630	COG2770	Histidine kinase
CS527_RS19630	COG2205	protein histidine kinase activity
CS527_RS19635	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CS527_RS19640	COG1607	acyl-coa hydrolase
CS527_RS19645	COG1802	Transcriptional regulator
CS527_RS19650	COG0697	spore germination
CS527_RS19660	COG0006	proline dipeptidase activity
CS527_RS19680	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS527_RS19685	COG5522	Integral membrane protein (intg_mem_TP0381)
CS527_RS19690	COG1174	glycine betaine transport
CS527_RS19695	COG0517	IMP dehydrogenase activity
CS527_RS19695	COG1125	glycine betaine transport
CS527_RS19710	COG2814	Major facilitator Superfamily
CS527_RS19720	COG0395	ABC-type sugar transport system, permease component
CS527_RS19740	COG1609	Transcriptional regulator
CS527_RS19745	COG2205	protein histidine kinase activity
CS527_RS19750	COG0730	response to heat
CS527_RS19755	COG1301	dicarboxylic acid transport
CS527_RS19770	COG0753	catalase activity
CS527_RS19795	COG1368	sulfuric ester hydrolase activity
CS527_RS19805	COG0697	spore germination
CS527_RS19810	COG1902	pentaerythritol trinitrate reductase activity
CS527_RS19825	COG1113	amino acid transport
CS527_RS19830	COG5505	Protein of unknown function (DUF819)
CS527_RS19835	COG1309	transcriptional regulator
CS527_RS19845	COG0583	DNA-binding transcription factor activity
CS527_RS19850	COG0730	response to heat
CS527_RS19855	COG1247	-acetyltransferase
CS527_RS19860	COG2910	NAD(P)H-binding
CS527_RS19865	COG1285	pathogenesis
CS527_RS19870	COG2226	methyltransferase
CS527_RS19875	COG4195	phage-related replication protein
CS527_RS19880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_RS19895	COG1113	amino acid transport
CS527_RS19925	COG0463	Glycosyl transferase, family 2
CS527_RS19950	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CS527_RS19955	COG2514	catechol 2,3-dioxygenase activity
CS527_RS19975	COG1280	lysine exporter protein (LysE YggA)
CS527_RS19980	COG1115	amino acid carrier protein
CS527_RS19990	COG0385	Bile acid
CS527_RS19995	COG0668	transmembrane transport
CS527_RS20000	COG2340	Cysteine-rich secretory protein family
CS527_RS20005	COG1253	flavin adenine dinucleotide binding
CS527_RS20015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CS527_RS20020	COG0589	response to stress
CS527_RS20025	COG0205	6-phosphofructokinase activity
CS527_RS20030	COG1388	LysM domain
CS527_RS20030	COG0791	NLP P60 protein
CS527_RS20040	COG0432	Pfam Uncharacterised protein family UPF0047
CS527_RS20045	COG0697	spore germination
CS527_RS20050	COG0814	amino acid
CS527_RS20075	COG1131	(ABC) transporter
CS527_RS20090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_RS20105	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_RS20115	COG1131	(ABC) transporter
CS527_RS20130	COG0706	membrane insertase activity
CS527_RS20140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_RS20140	COG1263	PTS System
CS527_RS20145	COG3711	transcriptional antiterminator
CS527_RS20150	COG2190	(PTS) system
CS527_RS20155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS527_RS20170	COG0772	Belongs to the SEDS family
CS527_RS20175	COG0659	secondary active sulfate transmembrane transporter activity
CS527_RS20180	COG0813	purine-nucleoside phosphorylase activity
CS527_RS20190	COG0671	phosphoesterase, PA-phosphatase related
CS527_RS20195	COG4326	sporulation control protein
CS527_RS20200	COG2815	serine threonine protein kinase
CS527_RS20200	COG0515	serine threonine protein kinase
CS527_RS20220	COG4479	Belongs to the UPF0346 family
CS527_RS20230	COG3594	Acyltransferase
CS527_RS20245	COG1509	lysine 2,3-aminomutase activity
CS527_RS20250	COG0456	acetyltransferase
CS527_RS20255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS527_RS20260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CS527_RS20265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS527_RS20270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS527_RS20275	COG1301	dicarboxylic acid transport
CS527_RS20285	COG4191	Histidine kinase
CS527_RS20310	COG2755	lipolytic protein G-D-S-L family
CS527_RS20315	COG1999	signal sequence binding
CS527_RS20325	COG1307	EDD domain protein, DegV family
CS527_RS20335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CS527_RS20345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CS527_RS20350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CS527_RS20355	COG0788	formyltetrahydrofolate deformylase activity
CS527_RS20385	COG0076	glutamate decarboxylase activity
CS527_RS20405	COG0415	Belongs to the DNA photolyase family
CS527_RS20410	COG3852	Histidine kinase
CS527_RS20425	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS20435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CS527_RS20445	COG4846	Membrane protein involved in cytochrome C biogenesis
CS527_RS20450	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CS527_RS20455	COG0785	Cytochrome C biogenesis protein
CS527_RS20465	COG1132	(ABC) transporter
CS527_RS20470	COG1132	(ABC) transporter
CS527_RS20490	COG4224	UPF0291 protein
CS527_RS20495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CS527_RS20520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS527_RS20525	COG0531	amino acid
CS527_RS20535	COG0174	glutamine synthetase
CS527_RS20540	COG0789	Transcriptional regulator
CS527_RS20545	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CS527_RS20550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CS527_RS20555	COG2860	membrane
CS527_RS20560	COG0464	growth
CS527_RS20570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CS527_RS20580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CS527_RS20585	COG0531	amino acid
CS527_RS20595	COG4550	Control of competence regulator ComK, YlbF/YmcA
CS527_RS20600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS527_RS20605	COG1013	pyruvate-flavodoxin oxidoreductase activity
CS527_RS20610	COG0674	pyruvate-flavodoxin oxidoreductase activity
CS527_RS20610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CS527_RS20620	COG2359	stage V sporulation protein S
CS527_RS20625	COG1692	metallophosphoesterase
CS527_RS20635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CS527_RS20640	COG1546	Belongs to the CinA family
CS527_RS20640	COG1058	Belongs to the CinA family
CS527_RS20645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CS527_RS20650	COG1426	Protein conserved in bacteria
CS527_RS20665	COG0300	oxidoreductase activity
CS527_RS20670	COG0612	Peptidase, M16
CS527_RS20675	COG0612	Peptidase, M16
CS527_RS20680	COG1079	Belongs to the binding-protein-dependent transport system permease family
CS527_RS20685	COG4603	Belongs to the binding-protein-dependent transport system permease family
CS527_RS20690	COG3845	ABC transporter
CS527_RS20695	COG1744	ABC transporter substrate-binding protein PnrA-like
CS527_RS20700	COG2188	Transcriptional regulator
CS527_RS20705	COG4980	gas vesicle protein
CS527_RS20705	COG1674	ftsk spoiiie
CS527_RS20715	COG0740	serine-type endopeptidase activity
CS527_RS20720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CS527_RS20730	COG0527	aspartate kinase activity
CS527_RS20735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CS527_RS20740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CS527_RS20745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS527_RS20750	COG1873	PFAM PRC-barrel domain
CS527_RS20755	COG0612	Peptidase, M16
CS527_RS20760	COG0726	polysaccharide deacetylase
CS527_RS20765	COG1185	polyribonucleotide nucleotidyltransferase activity
CS527_RS20770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CS527_RS20775	COG0196	riboflavin kinase activity
CS527_RS20785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CS527_RS20790	COG1550	Protein conserved in bacteria
CS527_RS20800	COG1358	cellular component organization or biogenesis
CS527_RS20805	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CS527_RS20810	COG0195	Participates in both transcription termination and antitermination
CS527_RS20815	COG0779	Required for maturation of 30S ribosomal subunits
CS527_RS20820	COG2176	DNA-directed DNA polymerase activity
CS527_RS20825	COG0442	prolyl-tRNA aminoacylation
CS527_RS20830	COG0750	zinc metalloprotease
CS527_RS20840	COG4589	Belongs to the CDS family
CS527_RS20850	COG0233	cytoplasmic translational termination
CS527_RS20860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CS527_RS20875	COG1191	sigma factor activity
CS527_RS20880	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CS527_RS20885	COG0835	chemotaxis
CS527_RS20890	COG0643	Histidine kinase
CS527_RS20890	COG2198	Histidine kinase
CS527_RS20895	COG2201	protein-glutamate methylesterase activity
CS527_RS20900	COG0455	bacterial-type flagellum organization
CS527_RS20905	COG1419	protein localization to endoplasmic reticulum
CS527_RS20910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CS527_RS20915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CS527_RS20920	COG1684	flagellar biosynthetic protein fliR
CS527_RS20925	COG1987	bacterial-type flagellum assembly
CS527_RS20930	COG1338	Plays a role in the flagellum-specific transport system
CS527_RS20935	COG3190	flagellar
CS527_RS20940	COG2201	protein-glutamate methylesterase activity
CS527_RS20945	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CS527_RS20945	COG1776	CheC inhibitor of MCP methylation
CS527_RS20950	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CS527_RS20960	COG1582	Flagellar protein (FlbD)
CS527_RS20965	COG4786	Flagellar basal body rod
CS527_RS20970	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CS527_RS20985	COG2882	bacterial-type flagellum organization
CS527_RS20990	COG1157	protein secretion by the type III secretion system
CS527_RS20995	COG1317	bacterial-type flagellum organization
CS527_RS21000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CS527_RS21005	COG1766	The M ring may be actively involved in energy transduction
CS527_RS21010	COG1677	Flagellar hook-basal body complex protein FliE
CS527_RS21015	COG1558	bacterial-type flagellum-dependent cell motility
CS527_RS21020	COG1815	bacterial-type flagellum-dependent cell motility
CS527_RS21025	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CS527_RS21030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CS527_RS21040	COG4974	Belongs to the 'phage' integrase family
CS527_RS21045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CS527_RS21050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS527_RS21055	COG0758	DNA mediated transformation
CS527_RS21060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CS527_RS21065	COG0045	succinate-CoA ligase (ADP-forming) activity
CS527_RS21085	COG0335	large ribosomal subunit rRNA binding
CS527_RS21095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CS527_RS21105	COG1837	Belongs to the UPF0109 family
CS527_RS21110	COG0228	four-way junction DNA binding
CS527_RS21115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CS527_RS21125	COG0552	protein localization to endoplasmic reticulum
CS527_RS21130	COG1196	nuclear chromosome segregation
CS527_RS21135	COG0571	ribonuclease III activity
CS527_RS21145	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS21150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CS527_RS21155	COG0416	fatty acid biosynthetic process
CS527_RS21160	COG1349	DNA-binding transcription factor activity
CS527_RS21165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CS527_RS21170	COG1760	l-serine dehydratase
CS527_RS21175	COG1760	l-serine dehydratase
CS527_RS21185	COG1461	Dihydroxyacetone kinase
CS527_RS21190	COG1302	Protein conserved in bacteria
CS527_RS21195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CS527_RS21205	COG1564	THIamine pyrophosphokinase
CS527_RS21210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CS527_RS21215	COG1162	GTPase activity
CS527_RS21220	COG0515	serine threonine protein kinase
CS527_RS21220	COG2815	serine threonine protein kinase
CS527_RS21225	COG0631	protein serine/threonine phosphatase activity
CS527_RS21235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CS527_RS21235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CS527_RS21240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CS527_RS21250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CS527_RS21255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CS527_RS21260	COG1758	RNA polymerase activity
CS527_RS21265	COG0194	GDP metabolic process
CS527_RS21270	COG2052	Domain of unknown function (DUF370)
CS527_RS21275	COG1561	YicC-like family, N-terminal region
CS527_RS21280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CS527_RS21290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CS527_RS21320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CS527_RS21325	COG0540	Belongs to the ATCase OTCase family
CS527_RS21335	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CS527_RS21340	COG0564	pseudouridine synthase activity
CS527_RS21345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CS527_RS21360	COG3599	regulation of cell shape
CS527_RS21365	COG2302	S4 RNA-binding domain
CS527_RS21370	COG0762	integral membrane protein
CS527_RS21375	COG1799	cell septum assembly
CS527_RS21380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CS527_RS21390	COG1873	PFAM PRC-barrel domain
CS527_RS21395	COG1191	sigma factor activity
CS527_RS21400	COG1191	sigma factor activity
CS527_RS21410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CS527_RS21415	COG0849	cell division
CS527_RS21420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CS527_RS21425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CS527_RS21430	COG0772	Belongs to the SEDS family
CS527_RS21435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CS527_RS21440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS527_RS21445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CS527_RS21450	COG0768	penicillin binding
CS527_RS21455	COG0768	penicillin binding
CS527_RS21460	COG4839	cell division protein FtsL
CS527_RS21470	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CS527_RS21480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CS527_RS21485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS527_RS21490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CS527_RS21495	COG0439	Biotin carboxylase
CS527_RS21500	COG0454	-acetyltransferase
CS527_RS21510	COG1024	Enoyl-CoA hydratase
CS527_RS21515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CS527_RS21520	COG1399	metal-binding, possibly nucleic acid-binding protein
CS527_RS21525	COG1323	Belongs to the UPF0348 family
CS527_RS21530	COG3480	Lon protease (S16) C-terminal proteolytic domain
CS527_RS21535	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS527_RS21540	COG3314	Sporulation integral membrane protein YlbJ
CS527_RS21545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CS527_RS21550	COG0742	ribosomal rna small subunit methyltransferase
CS527_RS21560	COG4471	UPF0298 protein
CS527_RS21570	COG3679	Belongs to the UPF0342 family
CS527_RS21590	COG4347	Protein of unknown function (DUF1405)
CS527_RS21600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CS527_RS21615	COG5582	Belongs to the UPF0302 family
CS527_RS21620	COG0457	Tetratricopeptide repeat
CS527_RS21625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CS527_RS21630	COG0287	Prephenate dehydrogenase
CS527_RS21635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CS527_RS21640	COG0159	tryptophan synthase activity
CS527_RS21650	COG0135	phosphoribosylanthranilate isomerase activity
CS527_RS21655	COG0134	indole-3-glycerol-phosphate synthase activity
CS527_RS21660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CS527_RS21670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CS527_RS21675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CS527_RS21680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CS527_RS21685	COG0105	UTP biosynthetic process
CS527_RS21690	COG0142	geranyltranstransferase activity
CS527_RS21695	COG2226	methyltransferase
CS527_RS21700	COG0142	geranyltranstransferase activity
CS527_RS21710	COG0302	gtp cyclohydrolase
CS527_RS21715	COG0776	regulation of translation
CS527_RS21720	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CS527_RS21755	COG2271	Major facilitator Superfamily
CS527_RS21760	COG1304	FMN binding
CS527_RS21765	COG0539	negative regulation of cytoplasmic translation
CS527_RS21775	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CS527_RS21785	COG2959	enzyme of heme biosynthesis
CS527_RS21790	COG3773	Cell wall hydrolase
CS527_RS21790	COG3409	Peptidoglycan-binding domain 1 protein
CS527_RS21795	COG2339	peptidase activity
CS527_RS21800	COG0252	asparaginase activity
CS527_RS21805	COG0492	ferredoxin-NADP+ reductase activity
CS527_RS21810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS527_RS21815	COG4862	establishment of competence for transformation
CS527_RS21820	COG0789	Transcriptional regulator
CS527_RS21825	COG1408	metallophosphoesterase
CS527_RS21840	COG1266	CAAX protease self-immunity
CS527_RS21855	COG1141	Ferredoxin
CS527_RS21860	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CS527_RS21865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CS527_RS21870	COG0739	heme binding
CS527_RS21875	COG5002	protein histidine kinase activity
CS527_RS21880	COG0745	RESPONSE REGULATOR receiver
CS527_RS21885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CS527_RS21890	COG1333	cytochrome c biogenesis protein
CS527_RS21895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_RS21900	COG1187	pseudouridine synthase activity
CS527_RS21905	COG0700	Nucleoside recognition
CS527_RS21910	COG2715	membrane protein required for spore maturation
CS527_RS21915	COG1686	Belongs to the peptidase S11 family
CS527_RS21920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CS527_RS21925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CS527_RS21935	COG1547	Domain of unknown function (DUF309)
CS527_RS21945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CS527_RS21950	COG4086	secreted protein
CS527_RS21960	COG0697	spore germination
CS527_RS21975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS527_RS22010	COG1686	Belongs to the peptidase S11 family
CS527_RS22025	COG4974	Belongs to the 'phage' integrase family
CS527_RS22035	COG0735	belongs to the Fur family
CS527_RS22040	COG1300	Membrane
CS527_RS22045	COG0494	nUDIX hydrolase
CS527_RS22055	COG0667	Aldo Keto reductase
CS527_RS22065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CS527_RS22070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS527_RS22080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CS527_RS22085	COG1073	alpha beta
CS527_RS22100	COG0300	oxidoreductase activity
CS527_RS22105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_RS22110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CS527_RS22115	COG1902	pentaerythritol trinitrate reductase activity
CS527_RS22120	COG1234	tRNA 3'-trailer cleavage
CS527_RS22125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS527_RS22130	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS22135	COG2508	Transcriptional regulator
CS527_RS22155	COG0167	dihydroorotate dehydrogenase activity
CS527_RS22155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CS527_RS22160	COG0493	'glutamate synthase
CS527_RS22165	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS527_RS22170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS527_RS22175	COG0346	lactoylglutathione lyase activity
CS527_RS22180	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_RS22185	COG4129	membrane
CS527_RS22190	COG1126	abc transporter atp-binding protein
CS527_RS22195	COG0765	amino acid transport
CS527_RS22200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_RS22210	COG1703	isobutyryl-CoA mutase activity
CS527_RS22215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_RS22215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_RS22220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_RS22220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_RS22225	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_RS22230	COG0022	dehydrogenase e1 component
CS527_RS22235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CS527_RS22240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS527_RS22255	COG0280	phosphate acetyltransferase
CS527_RS22260	COG3829	transcription factor binding
CS527_RS22260	COG3290	protein histidine kinase activity
CS527_RS22270	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_RS22275	COG3093	addiction module antidote protein HigA
CS527_RS22280	COG3104	oligopeptide transport
CS527_RS22285	COG0745	RESPONSE REGULATOR receiver
CS527_RS22290	COG0750	zinc metalloprotease
CS527_RS22295	COG0497	DNA recombination
CS527_RS22305	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CS527_RS22320	COG1722	exodeoxyribonuclease VII activity
CS527_RS22330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CS527_RS22335	COG1302	Protein conserved in bacteria
CS527_RS22340	COG0439	Biotin carboxylase
CS527_RS22345	COG0511	ligase activity, forming carbon-carbon bonds
CS527_RS22385	COG3854	ATPases associated with a variety of cellular activities
CS527_RS22395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CS527_RS22400	COG0006	proline dipeptidase activity
CS527_RS22405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CS527_RS22415	COG3872	metal-dependent enzyme
CS527_RS22425	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS527_RS22430	COG1321	iron dependent repressor
CS527_RS22435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS527_RS22440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS527_RS22445	COG0095	Lipoate-protein ligase
CS527_RS22450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS527_RS22460	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CS527_RS22465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CS527_RS22470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CS527_RS22500	COG4970	Tfp pilus assembly protein FimT
CS527_RS22505	COG4537	Required for transformation and DNA binding
CS527_RS22510	COG1459	type II secretion system
CS527_RS22515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CS527_RS22520	COG1393	Belongs to the ArsC family
CS527_RS22530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_RS22540	COG2866	Carboxypeptidase
CS527_RS22545	COG1940	carbohydrate kinase activity
CS527_RS22550	COG4483	Protein conserved in bacteria
CS527_RS22555	COG0457	Tetratricopeptide repeat
CS527_RS22555	COG0705	Rhomboid family
CS527_RS22565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CS527_RS22575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CS527_RS22590	COG0704	Plays a role in the regulation of phosphate uptake
CS527_RS22600	COG0768	penicillin binding
CS527_RS22605	COG0477	Major facilitator Superfamily
CS527_RS22640	COG2839	Protein conserved in bacteria
CS527_RS22650	COG2814	Major facilitator Superfamily
CS527_RS22655	COG1388	LysM domain
CS527_RS22660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CS527_RS22665	COG4709	membrane
CS527_RS22670	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CS527_RS22675	COG0735	belongs to the Fur family
CS527_RS22680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CS527_RS22685	COG1121	(ABC) transporter
CS527_RS22695	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CS527_RS22700	COG0513	Belongs to the DEAD box helicase family
CS527_RS22710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CS527_RS22715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CS527_RS22720	COG2384	SAM-dependent methyltransferase
CS527_RS22725	COG2010	Cytochrome c
CS527_RS22730	COG1960	acyl-CoA dehydrogenase activity
CS527_RS22735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CS527_RS22740	COG0358	DNA primase activity
CS527_RS22745	COG1671	Belongs to the UPF0178 family
CS527_RS22750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CS527_RS22755	COG0517	IMP dehydrogenase activity
CS527_RS22770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CS527_RS22775	COG0295	cytidine deaminase activity
CS527_RS22780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CS527_RS22790	COG1480	7TM receptor with intracellular HD hydrolase
CS527_RS22795	COG1702	phosphate starvation-inducible protein PhoH
CS527_RS22820	COG1030	water channel activity
CS527_RS22825	COG1610	YqeY-like protein
CS527_RS22835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS527_RS22840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CS527_RS22845	COG2264	protein methyltransferase activity
CS527_RS22860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CS527_RS22865	COG1420	regulation of RNA biosynthetic process
CS527_RS22870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CS527_RS22875	COG0481	GTPase activity
CS527_RS22885	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CS527_RS22890	COG0268	Binds directly to 16S ribosomal RNA
CS527_RS22895	COG1466	dna polymerase III delta subunit
CS527_RS22905	COG0658	competence protein
CS527_RS22905	COG2333	competence protein COMEC
CS527_RS22910	COG2131	deaminase
CS527_RS22915	COG1596	polysaccharide export
CS527_RS22915	COG1555	photosystem II stabilization
CS527_RS22920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CS527_RS22925	COG2226	methyltransferase
CS527_RS22930	COG0799	negative regulation of ribosome biogenesis
CS527_RS22935	COG1713	HD superfamily hydrolase involved in NAD metabolism
CS527_RS22940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CS527_RS22945	COG1534	Rna-binding protein
CS527_RS22950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CS527_RS22955	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CS527_RS22960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CS527_RS22970	COG0688	phosphatidylethanolamine metabolic process
CS527_RS22975	COG1183	phosphatidylcholine synthase activity
CS527_RS22995	COG0626	cystathionine gamma-synthase activity
CS527_RS23000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CS527_RS23005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CS527_RS23010	COG2226	methyltransferase
CS527_RS23025	COG0768	penicillin binding
CS527_RS23030	COG1335	isochorismatase
CS527_RS23035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CS527_RS23040	COG0572	uridine kinase
CS527_RS23045	COG0826	peptidase U32
CS527_RS23050	COG0826	peptidase U32
CS527_RS23055	COG4122	O-methyltransferase activity
CS527_RS23060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CS527_RS23065	COG3906	Belongs to the UPF0473 family
CS527_RS23075	COG4472	Bacterial protein of unknown function (DUF965)
CS527_RS23085	COG0628	permease
CS527_RS23100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CS527_RS23110	COG0482	sulfurtransferase activity
CS527_RS23115	COG1104	cysteine desulfurase activity
CS527_RS23120	COG1959	2 iron, 2 sulfur cluster binding
CS527_RS23125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CS527_RS23130	COG0581	inorganic phosphate transmembrane transporter activity
CS527_RS23135	COG0573	inorganic phosphate transmembrane transporter activity
CS527_RS23140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CS527_RS23145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CS527_RS23155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CS527_RS23160	COG0124	histidyl-tRNA synthetase
CS527_RS23170	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_RS23175	COG1490	D-aminoacyl-tRNA deacylase activity
CS527_RS23180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CS527_RS23185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CS527_RS23190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CS527_RS23190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CS527_RS23195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CS527_RS23195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CS527_RS23205	COG2244	polysaccharide biosynthetic process
CS527_RS23210	COG2323	membrane
CS527_RS23220	COG1862	Preprotein translocase
CS527_RS23225	COG0343	queuine tRNA-ribosyltransferase activity
CS527_RS23230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CS527_RS23240	COG2255	four-way junction helicase activity
CS527_RS23245	COG0632	four-way junction helicase activity
CS527_RS23270	COG1388	LysM domain
CS527_RS23275	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CS527_RS23280	COG0157	Belongs to the NadC ModD family
CS527_RS23285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CS527_RS23290	COG1104	cysteine desulfurase activity
CS527_RS23295	COG1827	regulation of RNA biosynthetic process
CS527_RS23300	COG0077	Prephenate dehydratase
CS527_RS23305	COG4492	Belongs to the UPF0735 family
CS527_RS23310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CS527_RS23315	COG3290	protein histidine kinase activity
CS527_RS23325	COG2868	ribosomal protein
CS527_RS23335	COG1530	ribonuclease E activity
CS527_RS23340	COG1994	Peptidase M50
CS527_RS23345	COG0739	heme binding
CS527_RS23350	COG2894	cell division
CS527_RS23355	COG0850	regulation of cytokinetic process
CS527_RS23360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CS527_RS23365	COG1792	Involved in formation and maintenance of cell shape
CS527_RS23370	COG1077	Cell shape determining protein MreB Mrl
CS527_RS23375	COG2003	Belongs to the UPF0758 family
CS527_RS23380	COG0424	maF-like protein
CS527_RS23390	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CS527_RS23400	COG2322	membrane
CS527_RS23405	COG0285	dihydrofolate synthase activity
CS527_RS23410	COG0525	valine-tRNA ligase activity
CS527_RS23420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CS527_RS23425	COG1388	LysM domain
CS527_RS23430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CS527_RS23435	COG0113	porphobilinogen synthase activity
CS527_RS23440	COG1587	Uroporphyrinogen-III synthase
CS527_RS23445	COG0181	hydroxymethylbilane synthase activity
CS527_RS23450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CS527_RS23465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CS527_RS23470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CS527_RS23475	COG0470	DNA polymerase III
CS527_RS23475	COG1067	ATP-dependent peptidase activity
CS527_RS23480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CS527_RS23485	COG0544	peptidyl-prolyl cis-trans isomerase activity
CS527_RS23490	COG1477	protein flavinylation
CS527_RS23490	COG0457	Tetratricopeptide repeat
CS527_RS23495	COG0066	3-isopropylmalate dehydratase activity
CS527_RS23500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CS527_RS23510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CS527_RS23515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CS527_RS23520	COG0440	acetolactate synthase activity
CS527_RS23525	COG0028	Belongs to the TPP enzyme family
CS527_RS23535	COG0622	Phosphoesterase
CS527_RS23545	COG5401	PFAM Sporulation and spore germination
CS527_RS23550	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CS527_RS23555	COG1846	Transcriptional regulator
CS527_RS23565	COG0306	phosphate transporter
CS527_RS23570	COG1392	Phosphate transport regulator
CS527_RS23575	COG0768	penicillin binding
CS527_RS23585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_RS23590	COG0431	NADPH-dependent FMN reductase
CS527_RS23595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS527_RS23600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS527_RS23605	COG1116	anion transmembrane transporter activity
CS527_RS23610	COG0475	glutathione-regulated potassium exporter activity
CS527_RS23615	COG0490	domain, Protein
CS527_RS23625	COG2197	response regulator
CS527_RS23630	COG0824	Thioesterase
CS527_RS23635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CS527_RS23640	COG1053	succinate dehydrogenase
CS527_RS23645	COG2009	succinate dehydrogenase
CS527_RS23650	COG1719	4-vinyl reductase, 4VR
CS527_RS23655	COG0527	aspartate kinase activity
CS527_RS23665	COG3118	belongs to the thioredoxin family
CS527_RS23675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CS527_RS23680	COG2086	electron transfer activity
CS527_RS23685	COG1024	Enoyl-CoA hydratase
CS527_RS23690	COG1309	transcriptional regulator
CS527_RS23695	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_RS23700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CS527_RS23705	COG3766	membrane
CS527_RS23710	COG1193	negative regulation of DNA recombination
CS527_RS23715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CS527_RS23715	COG1796	DNA polymerase
CS527_RS23720	COG1286	toxin biosynthetic process
CS527_RS23725	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CS527_RS23735	COG0072	phenylalanine-tRNA ligase activity
CS527_RS23735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS527_RS23740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CS527_RS23745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS527_RS23755	COG1363	Peptidase, m42
CS527_RS23775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CS527_RS23780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CS527_RS23785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CS527_RS23790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CS527_RS23800	COG1484	DNA-dependent DNA replication
CS527_RS23805	COG3611	Membrane attachment protein
CS527_RS23810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CS527_RS23820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CS527_RS23825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CS527_RS23830	COG0237	dephospho-CoA kinase activity
CS527_RS23835	COG1971	Probably functions as a manganese efflux pump
CS527_RS23840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CS527_RS23845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS527_RS23845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS527_RS23850	COG5002	protein histidine kinase activity
CS527_RS23855	COG0745	RESPONSE REGULATOR receiver
CS527_RS23865	COG0039	L-malate dehydrogenase activity
CS527_RS23870	COG0538	isocitrate dehydrogenase activity
CS527_RS23875	COG0372	Belongs to the citrate synthase family
CS527_RS23880	COG2707	UPF0756 membrane protein
CS527_RS23885	COG0628	permease
CS527_RS23890	COG3030	protein affecting phage T7 exclusion by the F plasmid
CS527_RS23900	COG0825	malonyl-CoA metabolic process
CS527_RS23905	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CS527_RS23910	COG2186	Transcriptional regulator
CS527_RS23915	COG0281	malic enzyme
CS527_RS23920	COG0587	DNA-directed DNA polymerase activity
CS527_RS23935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CS527_RS23945	COG4109	DRTGG domain
CS527_RS23955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CS527_RS23965	COG0165	Argininosuccinate lyase
CS527_RS23970	COG0137	argininosuccinate synthase activity
CS527_RS23985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CS527_RS23990	COG0827	DNA restriction-modification system
CS527_RS23995	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CS527_RS24000	COG3874	Sporulation protein YtfJ
CS527_RS24010	COG1714	RDD family
CS527_RS24015	COG0616	signal peptide processing
CS527_RS24020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CS527_RS24025	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CS527_RS24035	COG0301	tRNA thio-modification
CS527_RS24040	COG1104	cysteine desulfurase activity
CS527_RS24045	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CS527_RS24050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CS527_RS24055	COG1309	transcriptional regulator
CS527_RS24060	COG1956	GAF domain-containing protein
CS527_RS24075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CS527_RS24080	COG0454	-acetyltransferase
CS527_RS24085	COG0517	IMP dehydrogenase activity
CS527_RS24090	COG0123	including yeast histone deacetylase and acetoin utilization protein
CS527_RS24110	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CS527_RS24110	COG1605	Chorismate mutase
CS527_RS24115	COG3118	belongs to the thioredoxin family
CS527_RS24120	COG4980	gas vesicle protein
CS527_RS24135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CS527_RS24145	COG1674	ftsk spoiiie
CS527_RS24150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS527_RS24155	COG4848	Belongs to the UPF0354 family
CS527_RS24160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_RS24165	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CS527_RS24170	COG1363	Peptidase, m42
CS527_RS24175	COG5584	Small secreted protein
CS527_RS24180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_RS24185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CS527_RS24195	COG0510	thiamine kinase activity
CS527_RS24200	COG1523	belongs to the glycosyl hydrolase 13 family
CS527_RS24210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CS527_RS24220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS527_RS24225	COG1349	DNA-binding transcription factor activity
CS527_RS24230	COG1187	pseudouridine synthase activity
CS527_RS24235	COG2244	polysaccharide biosynthetic process
CS527_RS24240	COG2081	HI0933 family
CS527_RS24250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS527_RS24255	COG0495	leucyl-tRNA aminoacylation
CS527_RS24265	COG2610	gluconate transmembrane transporter activity
CS527_RS24270	COG2814	Major facilitator Superfamily
CS527_RS24285	COG1242	4 iron, 4 sulfur cluster binding
CS527_RS24290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CS527_RS24300	COG2267	carboxylic ester hydrolase activity
CS527_RS24305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CS527_RS24310	COG0671	phosphoesterase, PA-phosphatase related
CS527_RS24315	COG0438	transferase activity, transferring glycosyl groups
CS527_RS24320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CS527_RS24325	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CS527_RS24335	COG1506	peptidase
CS527_RS24340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS527_RS24345	COG1116	anion transmembrane transporter activity
CS527_RS24350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS527_RS24355	COG0494	nUDIX hydrolase
CS527_RS24365	COG4824	toxin secretion phage lysis holin
CS527_RS24370	COG0783	Belongs to the Dps family
CS527_RS24380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CS527_RS24385	COG0288	reversible hydration of carbon dioxide
CS527_RS24390	COG0523	cobalamin synthesis protein
CS527_RS24400	COG0254	rRNA binding
CS527_RS24405	COG1271	oxidase subunit
CS527_RS24410	COG1294	oxidase, subunit
CS527_RS24415	COG0716	FMN binding
CS527_RS24440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS527_RS24445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS527_RS24450	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_RS24455	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_RS24460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CS527_RS24465	COG0596	Alpha beta hydrolase
CS527_RS24470	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CS527_RS24475	COG1169	isochorismate synthase
CS527_RS24480	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CS527_RS24490	COG0058	SHG alpha-glucan phosphorylase activity
CS527_RS24495	COG0297	glycogen (starch) synthase activity
CS527_RS24500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CS527_RS24505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CS527_RS24635	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_RS24640	COG1285	pathogenesis
CS527_RS24660	COG0529	Catalyzes the synthesis of activated sulfate
CS527_RS24670	COG0306	phosphate transporter
CS527_RS24680	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CS527_RS24685	COG0346	lactoylglutathione lyase activity
CS527_RS24690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CS527_RS24705	COG0166	Belongs to the GPI family
CS527_RS24715	COG2111	Na H antiporter
CS527_RS24715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CS527_RS24720	COG2111	Na H antiporter
CS527_RS24725	COG1006	Multisubunit Na H antiporter MnhC subunit
CS527_RS24730	COG0651	ATP synthesis coupled electron transport
CS527_RS24735	COG1863	multisubunit Na H antiporter MnhE subunit
CS527_RS24740	COG2212	antiporter activity
CS527_RS24745	COG1320	monovalent cation:proton antiporter activity
CS527_RS24750	COG1979	alcohol dehydrogenase
CS527_RS24755	COG2155	Conserved Protein
CS527_RS24760	COG1098	S1 RNA binding domain
CS527_RS24765	COG0436	Aminotransferase
CS527_RS24770	COG1522	sequence-specific DNA binding
CS527_RS24775	COG2267	carboxylic ester hydrolase activity
CS527_RS24780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CS527_RS24785	COG2032	superoxide dismutase activity
CS527_RS24800	COG5018	Exonuclease
CS527_RS24805	COG2050	protein possibly involved in aromatic compounds catabolism
CS527_RS24815	COG1418	mRNA catabolic process
CS527_RS24825	COG2056	Na+-H+ antiporter family
CS527_RS24830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CS527_RS24835	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CS527_RS24840	COG3584	3D domain protein
CS527_RS24850	COG1252	NADH dehydrogenase
CS527_RS24855	COG0492	ferredoxin-NADP+ reductase activity
CS527_RS24865	COG0316	Belongs to the HesB IscA family
CS527_RS24870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CS527_RS24880	COG4844	belongs to the
CS527_RS24885	COG1252	NADH dehydrogenase
CS527_RS24890	COG4837	Protein of unknown function (DUF1462)
CS527_RS24895	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CS527_RS24900	COG0083	homoserine kinase activity
CS527_RS24905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CS527_RS24910	COG0460	homoserine dehydrogenase
CS527_RS24915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS527_RS24920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CS527_RS24925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CS527_RS24930	COG0647	UMP catabolic process
CS527_RS24935	COG2445	Protein of unknown function DUF86
CS527_RS24945	COG4470	Protein conserved in bacteria
CS527_RS24955	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CS527_RS24960	COG0739	heme binding
CS527_RS24980	COG3377	Domain of unknown function (DUF1805)
CS527_RS24985	COG1801	Protein of unknown function DUF72
CS527_RS24990	COG0719	Fe-S assembly protein
CS527_RS24995	COG0822	iron-sulfur transferase activity
CS527_RS25000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CS527_RS25005	COG0719	Fe-S assembly protein
CS527_RS25010	COG0396	ATPase activity
CS527_RS25015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CS527_RS25020	COG1464	Belongs to the NlpA lipoprotein family
CS527_RS25025	COG2011	ABC-type metal ion transport system permease component
CS527_RS25030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS527_RS25035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_RS25040	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CS527_RS25050	COG0509	glycine decarboxylation via glycine cleavage system
CS527_RS25055	COG1393	Belongs to the ArsC family
CS527_RS25060	COG1960	acyl-CoA dehydrogenase activity
CS527_RS25065	COG0183	Belongs to the thiolase family
CS527_RS25070	COG1024	Enoyl-CoA hydratase
CS527_RS25070	COG1250	3-hydroxyacyl-CoA dehydrogenase
CS527_RS25095	COG1120	ATPase activity
CS527_RS25100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_RS25105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_RS25110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_RS25120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CS527_RS25125	COG1309	transcriptional regulator
CS527_RS25135	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_RS25140	COG0477	Major facilitator Superfamily
CS527_RS25150	COG5002	protein histidine kinase activity
CS527_RS25150	COG3850	Histidine kinase
CS527_RS25155	COG0745	RESPONSE REGULATOR receiver
CS527_RS25160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CS527_RS25165	COG0671	phosphoesterase, PA-phosphatase related
CS527_RS25175	COG1846	Transcriptional regulator
CS527_RS25180	COG0778	Nitroreductase
CS527_RS25185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CS527_RS25190	COG0314	molybdopterin synthase activity
CS527_RS25195	COG1763	Mo-molybdopterin cofactor biosynthetic process
CS527_RS25200	COG0303	'Molybdopterin
CS527_RS25205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CS527_RS25210	COG0746	molybdenum cofactor guanylyltransferase activity
CS527_RS25220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CS527_RS25225	COG5609	conserved protein (DUF2294)
CS527_RS25230	COG3383	formate dehydrogenase (NAD+) activity
CS527_RS25235	COG2427	Protein of unknown function (DUF1641)
CS527_RS25240	COG0725	ABC transporter, periplasmic molybdate-binding protein
CS527_RS25245	COG4149	molybdate abc transporter
CS527_RS25255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CS527_RS25260	COG0557	exoribonuclease II activity
CS527_RS25265	COG1647	Serine aminopeptidase, S33
CS527_RS25270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CS527_RS25280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CS527_RS25310	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CS527_RS25330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_RS25340	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CS527_RS25345	COG1660	Displays ATPase and GTPase activities
CS527_RS25350	COG1051	belongs to the nudix hydrolase family
CS527_RS25355	COG0492	ferredoxin-NADP+ reductase activity
CS527_RS25360	COG0457	Tetratricopeptide repeat
CS527_RS25365	COG0140	phosphoribosyl-ATP diphosphatase activity
CS527_RS25365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CS527_RS25370	COG0107	imidazoleglycerol-phosphate synthase activity
CS527_RS25375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CS527_RS25380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CS527_RS25385	COG0131	Imidazoleglycerol-phosphate dehydratase
CS527_RS25390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CS527_RS25395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CS527_RS25400	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CS527_RS25405	COG0110	maltose O-acetyltransferase activity
CS527_RS25410	COG0546	phosphoglycolate phosphatase activity
CS527_RS25415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CS527_RS25420	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CS527_RS25425	COG1950	PFAM Membrane protein of
CS527_RS25435	COG3595	metallopeptidase activity
CS527_RS25445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CS527_RS25450	COG0556	nucleotide-excision repair
CS527_RS25455	COG2204	response regulator
CS527_RS25460	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS25465	COG0506	proline dehydrogenase activity
CS527_RS25470	COG4897	Protein conserved in bacteria
CS527_RS25475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS527_RS25480	COG0793	Belongs to the peptidase S41A family
CS527_RS25480	COG3409	Peptidoglycan-binding domain 1 protein
CS527_RS25485	COG0739	heme binding
CS527_RS25490	COG2177	Part of the ABC transporter FtsEX involved in
CS527_RS25495	COG2884	Cell division ATP-binding protein ftsE
CS527_RS25500	COG0655	NAD(P)H dehydrogenase (quinone) activity
CS527_RS25510	COG0805	protein transport
CS527_RS25515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS527_RS25520	COG3540	Alkaline phosphatase
CS527_RS25530	COG0653	protein targeting
CS527_RS25535	COG0456	acetyltransferase
CS527_RS25540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CS527_RS25550	COG1516	flagellar protein fliS
CS527_RS25555	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CS527_RS25565	COG1113	amino acid transport
CS527_RS25575	COG1012	belongs to the aldehyde dehydrogenase family
CS527_RS25580	COG1454	alcohol dehydrogenase
CS527_RS25585	COG1510	regulation of RNA biosynthetic process
CS527_RS25590	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CS527_RS25595	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CS527_RS25600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CS527_RS25605	COG1256	bacterial-type flagellum assembly
CS527_RS25605	COG4786	Flagellar basal body rod
CS527_RS25625	COG1040	competence protein
CS527_RS25630	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CS527_RS25635	COG1307	EDD domain protein, DegV family
CS527_RS25640	COG1728	Protein conserved in bacteria
CS527_RS25650	COG2197	response regulator
CS527_RS25655	COG4585	Histidine kinase
CS527_RS25660	COG1739	Uncharacterized protein family UPF0029
CS527_RS25665	COG1316	TRANSCRIPTIONal
CS527_RS25670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS527_RS25675	COG1585	Membrane protein implicated in regulation of membrane protease activity
CS527_RS25680	COG2268	Band 7 protein
CS527_RS25685	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CS527_RS25695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS527_RS25705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CS527_RS25710	COG0791	NLP P60 protein
CS527_RS25710	COG1388	LysM domain
CS527_RS25715	COG0629	single-stranded DNA binding
CS527_RS25740	COG4786	Flagellar basal body rod
CS527_RS25745	COG4786	Flagellar basal body rod
CS527_RS25750	COG1077	Cell shape determining protein MreB Mrl
CS527_RS25755	COG1609	Transcriptional regulator
CS527_RS25760	COG0739	heme binding
CS527_RS25765	COG2385	sporulation resulting in formation of a cellular spore
CS527_RS25780	COG4836	Membrane
CS527_RS25785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CS527_RS25790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CS527_RS25795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CS527_RS25800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CS527_RS25805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CS527_RS25810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CS527_RS25815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CS527_RS25820	COG0356	it plays a direct role in the translocation of protons across the membrane
CS527_RS25835	COG1404	Belongs to the peptidase S8 family
CS527_RS25840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CS527_RS25845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CS527_RS25860	COG0698	ribose 5-phosphate isomerase
CS527_RS25870	COG1971	Probably functions as a manganese efflux pump
CS527_RS25875	COG0009	L-threonylcarbamoyladenylate synthase
CS527_RS25895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CS527_RS25910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CS527_RS25920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CS527_RS25925	COG0191	fructose-bisphosphate aldolase activity
CS527_RS25930	COG2204	response regulator
CS527_RS25935	COG4821	SIS domain
CS527_RS25940	COG0504	CTP synthase activity
CS527_RS25950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_RS25950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_RS25950	COG1703	isobutyryl-CoA mutase activity
CS527_RS25960	COG1960	acyl-CoA dehydrogenase activity
CS527_RS25965	COG1960	acyl-CoA dehydrogenase activity
CS527_RS25970	COG1250	3-hydroxyacyl-CoA dehydrogenase
CS527_RS25975	COG0183	Belongs to the thiolase family
CS527_RS25980	COG2181	nitrate reductase activity
CS527_RS25980	COG0247	lactate metabolic process
CS527_RS25985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_RS25995	COG0018	arginyl-trna synthetase
CS527_RS26000	COG4506	Protein conserved in bacteria
CS527_RS26005	COG0010	Belongs to the arginase family
CS527_RS26010	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CS527_RS26015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS527_RS26025	COG1994	Peptidase M50
CS527_RS26030	COG1942	4-Oxalocrotonate Tautomerase
CS527_RS26035	COG3465	dGTPase activity
CS527_RS26040	COG1078	dGTPase activity
CS527_RS26045	COG4844	belongs to the
CS527_RS26055	COG0095	Lipoate-protein ligase
CS527_RS26060	COG0280	phosphate acetyltransferase
CS527_RS26065	COG3253	May function as heme-dependent peroxidase
CS527_RS26070	COG3773	Cell wall hydrolase
CS527_RS26080	COG2363	Small membrane protein
CS527_RS26090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CS527_RS26100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CS527_RS26105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CS527_RS26110	COG2508	Transcriptional regulator
CS527_RS26110	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CS527_RS26115	COG0686	Belongs to the AlaDH PNT family
CS527_RS26125	COG0351	phosphomethylpyrimidine kinase
CS527_RS26130	COG0561	phosphatase activity
CS527_RS26135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CS527_RS26140	COG2190	(PTS) system
CS527_RS26140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_RS26140	COG1263	PTS System
CS527_RS26150	COG0438	transferase activity, transferring glycosyl groups
CS527_RS26165	COG2076	Multidrug Resistance protein
CS527_RS26175	COG0728	peptidoglycan biosynthetic process
CS527_RS26190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CS527_RS26195	COG4988	ABC transporter
CS527_RS26200	COG1294	oxidase, subunit
CS527_RS26205	COG1271	oxidase subunit
CS527_RS26210	COG3610	response to peptide
CS527_RS26215	COG2966	Psort location CytoplasmicMembrane, score
CS527_RS26220	COG1609	Transcriptional regulator
CS527_RS26230	COG2814	Major facilitator Superfamily
CS527_RS26245	COG1966	Carbon starvation protein
CS527_RS26250	COG0753	catalase activity
CS527_RS26265	COG0471	metal ion transport
CS527_RS26270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CS527_RS26280	COG0745	RESPONSE REGULATOR receiver
CS527_RS26285	COG5002	protein histidine kinase activity
CS527_RS26300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CS527_RS26305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CS527_RS26315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS527_RS26320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CS527_RS26325	COG4853	Protein conserved in bacteria
CS527_RS26335	COG5002	protein histidine kinase activity
CS527_RS26340	COG0745	RESPONSE REGULATOR receiver
CS527_RS26365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CS527_RS26370	COG0305	Participates in initiation and elongation during chromosome replication
CS527_RS26380	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CS527_RS26390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CS527_RS26400	COG0360	Binds together with S18 to 16S ribosomal RNA
CS527_RS26405	COG0012	GTP binding
CS527_RS26410	COG4481	Protein conserved in bacteria
CS527_RS26415	COG0668	transmembrane transport
CS527_RS26420	COG3949	Membrane
CS527_RS26430	COG1475	DNA binding
CS527_RS26435	COG1192	Involved in chromosome partitioning
CS527_RS26440	COG1475	DNA binding
CS527_RS26450	COG0445	tRNA wobble uridine modification
CS527_RS26455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CS527_RS26460	COG1847	R3H domain protein
CS527_RS26465	COG0706	membrane insertase activity
CS527_RS26470	COG0594	ribonuclease P activity
CS527_RS26475	COG0230	Belongs to the bacterial ribosomal protein bL34 family