locus-tag	class	description
DOE78_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DOE78_RS00010	COG0592	DNA-directed DNA polymerase activity
DOE78_RS00015	COG2501	S4 domain
DOE78_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DOE78_RS00030	COG0187	DNA topoisomerase II activity
DOE78_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DOE78_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DOE78_RS00075	COG0517	IMP dehydrogenase activity
DOE78_RS00075	COG0516	GMP reductase activity
DOE78_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DOE78_RS00105	COG1428	Deoxynucleoside kinase
DOE78_RS00110	COG1428	Deoxynucleoside kinase
DOE78_RS00115	COG3858	chitin binding
DOE78_RS00115	COG1388	LysM domain
DOE78_RS00120	COG1335	isochorismatase
DOE78_RS00125	COG0590	tRNA wobble adenosine to inosine editing
DOE78_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DOE78_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DOE78_RS00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DOE78_RS00190	COG1982	Orn Lys Arg decarboxylase major
DOE78_RS00195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DOE78_RS00200	COG3870	Protein conserved in bacteria
DOE78_RS00205	COG1728	Protein conserved in bacteria
DOE78_RS00210	COG0470	DNA polymerase III
DOE78_RS00215	COG1774	PSP1 C-terminal conserved region
DOE78_RS00220	COG4467	Involved in initiation control of chromosome replication
DOE78_RS00225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DOE78_RS00230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DOE78_RS00235	COG2002	toxin-antitoxin pair type II binding
DOE78_RS00245	COG0084	hydrolase, TatD family'
DOE78_RS00250	COG3583	domain protein
DOE78_RS00250	COG3584	3D domain protein
DOE78_RS00260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DOE78_RS00275	COG4466	Protein conserved in bacteria
DOE78_RS00290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DOE78_RS00295	COG0251	oxidation-reduction process
DOE78_RS00300	COG2088	sporulation resulting in formation of a cellular spore
DOE78_RS00305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DOE78_RS00315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DOE78_RS00330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DOE78_RS00335	COG2002	toxin-antitoxin pair type II binding
DOE78_RS00340	COG2244	polysaccharide biosynthetic process
DOE78_RS00345	COG3956	TIGRFAM MazG family protein
DOE78_RS00350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DOE78_RS00370	COG1098	S1 RNA binding domain
DOE78_RS00380	COG2208	phosphoserine phosphatase activity
DOE78_RS00385	COG2304	oxidoreductase activity
DOE78_RS00390	COG0515	serine threonine protein kinase
DOE78_RS00395	COG0037	tRNA processing
DOE78_RS00400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DOE78_RS00405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DOE78_RS00410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DOE78_RS00415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DOE78_RS00420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOE78_RS00425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DOE78_RS00430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DOE78_RS00435	COG0512	Glutamine amidotransferase of anthranilate synthase
DOE78_RS00440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DOE78_RS00445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DOE78_RS00450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DOE78_RS00455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DOE78_RS00460	COG1396	sequence-specific DNA binding
DOE78_RS00465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOE78_RS00555	COG3880	PFAM UvrB UvrC protein
DOE78_RS00560	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DOE78_RS00565	COG0542	response to heat
DOE78_RS00570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DOE78_RS00575	COG4956	integral membrane protein (PIN domain superfamily)
DOE78_RS00580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DOE78_RS00590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DOE78_RS00595	COG1045	serine acetyltransferase
DOE78_RS00600	COG0215	cysteine-tRNA ligase activity
DOE78_RS00610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOE78_RS00615	COG3688	RNA-binding protein containing a PIN domain
DOE78_RS00625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DOE78_RS00630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DOE78_RS00635	COG0250	Participates in transcription elongation, termination and antitermination
DOE78_RS00640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DOE78_RS00645	COG0081	regulation of translation
DOE78_RS00650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DOE78_RS00655	COG0222	ribosome binding
DOE78_RS00660	COG2813	Specifically methylates the guanine in position
DOE78_RS00670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DOE78_RS00675	COG1358	cellular component organization or biogenesis
DOE78_RS00680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DOE78_RS00685	COG0049	tRNA binding
DOE78_RS00690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DOE78_RS00695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DOE78_RS00700	COG0175	sulfate reduction
DOE78_RS00705	COG0306	phosphate transporter
DOE78_RS00710	COG2046	Belongs to the sulfate adenylyltransferase family
DOE78_RS00715	COG0529	Catalyzes the synthesis of activated sulfate
DOE78_RS00720	COG0051	transcription antitermination factor activity, RNA binding
DOE78_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DOE78_RS00730	COG0088	Forms part of the polypeptide exit tunnel
DOE78_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DOE78_RS00745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DOE78_RS00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DOE78_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DOE78_RS00765	COG0255	Belongs to the universal ribosomal protein uL29 family
DOE78_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DOE78_RS00780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DOE78_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DOE78_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DOE78_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DOE78_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DOE78_RS00815	COG1841	ribosomal large subunit assembly
DOE78_RS00825	COG0201	protein transport
DOE78_RS00830	COG0563	adenylate kinase activity
DOE78_RS00835	COG0024	Methionine aminopeptidase
DOE78_RS00840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DOE78_RS00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DOE78_RS00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DOE78_RS00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DOE78_RS00860	COG0202	RNA polymerase activity
DOE78_RS00865	COG0203	ribosomal protein L17
DOE78_RS00870	COG1122	ATPase activity
DOE78_RS00875	COG1122	ATPase activity
DOE78_RS00880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DOE78_RS00885	COG0101	tRNA pseudouridine synthase activity
DOE78_RS00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DOE78_RS00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DOE78_RS00900	COG5002	protein histidine kinase activity
DOE78_RS00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOE78_RS00915	COG0489	protein tyrosine kinase activity
DOE78_RS00925	COG2194	sulfuric ester hydrolase activity
DOE78_RS00930	COG0726	polysaccharide deacetylase
DOE78_RS01005	COG1595	DNA-templated transcription, initiation
DOE78_RS01010	COG5662	AntiSigma factor
DOE78_RS01015	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DOE78_RS01020	COG4856	YbbR-like protein
DOE78_RS01025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOE78_RS01030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DOE78_RS01035	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DOE78_RS01040	COG0446	pyridine nucleotide-disulphide oxidoreductase
DOE78_RS01045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOE78_RS01045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DOE78_RS01055	COG1937	Protein conserved in bacteria
DOE78_RS01060	COG2210	Belongs to the sulfur carrier protein TusA family
DOE78_RS01065	COG1054	Belongs to the UPF0176 family
DOE78_RS01075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DOE78_RS01075	COG0425	Belongs to the sulfur carrier protein TusA family
DOE78_RS01080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DOE78_RS01080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOE78_RS01085	COG0425	Belongs to the sulfur carrier protein TusA family
DOE78_RS01090	COG0730	response to heat
DOE78_RS01100	COG0697	spore germination
DOE78_RS01120	COG0583	DNA-binding transcription factor activity
DOE78_RS01125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DOE78_RS01135	COG0531	amino acid
DOE78_RS01140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOE78_RS01155	COG3711	transcriptional antiterminator
DOE78_RS01175	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS01175	COG1454	alcohol dehydrogenase
DOE78_RS01185	COG0783	Belongs to the Dps family
DOE78_RS01190	COG0772	Belongs to the SEDS family
DOE78_RS01200	COG0697	spore germination
DOE78_RS01215	COG2239	Acts as a magnesium transporter
DOE78_RS01225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DOE78_RS01235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DOE78_RS01240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOE78_RS01245	COG1120	ATPase activity
DOE78_RS01250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DOE78_RS01260	COG2096	Adenosyltransferase
DOE78_RS01265	COG0346	lactoylglutathione lyase activity
DOE78_RS01270	COG1686	Belongs to the peptidase S11 family
DOE78_RS01275	COG1181	Belongs to the D-alanine--D-alanine ligase family
DOE78_RS01280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DOE78_RS01285	COG0561	phosphatase activity
DOE78_RS01290	COG0596	Alpha beta hydrolase
DOE78_RS01295	COG0513	Belongs to the DEAD box helicase family
DOE78_RS01300	COG4294	response to UV
DOE78_RS01305	COG3402	PFAM membrane-flanked domain
DOE78_RS01310	COG3428	Bacterial PH domain
DOE78_RS01315	COG0705	Rhomboid family
DOE78_RS01320	COG0736	holo-[acyl-carrier-protein] synthase activity
DOE78_RS01325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DOE78_RS01335	COG0864	Transcriptional regulator
DOE78_RS01340	COG2337	Toxic component of a toxin-antitoxin (TA) module
DOE78_RS01345	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS01350	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS01355	COG2172	sigma factor antagonist activity
DOE78_RS01360	COG2208	phosphoserine phosphatase activity
DOE78_RS01365	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS01370	COG2172	sigma factor antagonist activity
DOE78_RS01375	COG1191	sigma factor activity
DOE78_RS01380	COG2208	phosphoserine phosphatase activity
DOE78_RS01385	COG2183	response to ionizing radiation
DOE78_RS01395	COG3091	SprT-like family
DOE78_RS01480	COG0802	atpase or kinase
DOE78_RS01485	COG1214	PFAM Peptidase M22, glycoprotease
DOE78_RS01490	COG0456	acetyltransferase
DOE78_RS01500	COG0488	(ABC) transporter
DOE78_RS01505	COG0315	cyclic pyranopterin monophosphate synthase activity
DOE78_RS01510	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DOE78_RS01520	COG1266	CAAX protease self-immunity
DOE78_RS01525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DOE78_RS01530	COG0459	protein refolding
DOE78_RS01535	COG0784	Response regulator, receiver
DOE78_RS01540	COG4191	Histidine kinase
DOE78_RS01545	COG1115	amino acid carrier protein
DOE78_RS01550	COG2066	Belongs to the glutaminase family
DOE78_RS01555	COG0252	asparaginase activity
DOE78_RS01560	COG1027	Aspartate ammonia-lyase
DOE78_RS01565	COG1757	Na H antiporter
DOE78_RS01605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOE78_RS01610	COG1396	sequence-specific DNA binding
DOE78_RS01615	COG0747	negative chemotaxis
DOE78_RS01620	COG0601	transmembrane transport
DOE78_RS01625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOE78_RS01635	COG4608	Belongs to the ABC transporter superfamily
DOE78_RS01645	COG2304	oxidoreductase activity
DOE78_RS01665	COG0840	transmembrane signaling receptor activity
DOE78_RS01670	COG0840	transmembrane signaling receptor activity
DOE78_RS01675	COG2814	Major facilitator Superfamily
DOE78_RS01680	COG2304	oxidoreductase activity
DOE78_RS01750	COG0737	Belongs to the 5'-nucleotidase family
DOE78_RS01755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOE78_RS01760	COG1554	hydrolase, family 65, central catalytic
DOE78_RS01765	COG0714	Associated with various cellular activities
DOE78_RS01770	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DOE78_RS01775	COG1305	Transglutaminase-like
DOE78_RS01780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DOE78_RS01780	COG0519	Catalyzes the synthesis of GMP from XMP
DOE78_RS01785	COG2252	PERMEase
DOE78_RS01790	COG3711	transcriptional antiterminator
DOE78_RS01795	COG2190	(PTS) system
DOE78_RS01795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOE78_RS01795	COG1263	PTS System
DOE78_RS01815	COG0531	amino acid
DOE78_RS01825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DOE78_RS01830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DOE78_RS01835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DOE78_RS01845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DOE78_RS01850	COG0047	phosphoribosylformylglycinamidine synthase activity
DOE78_RS01860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DOE78_RS01865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DOE78_RS01870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DOE78_RS01880	COG0151	Belongs to the GarS family
DOE78_RS01895	COG1470	cell adhesion involved in biofilm formation
DOE78_RS01900	COG4496	protein, YerC YecD
DOE78_RS01905	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DOE78_RS01910	COG0210	DNA helicase
DOE78_RS01915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DOE78_RS01920	COG4851	CamS sex pheromone cAM373 precursor
DOE78_RS01925	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS01930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DOE78_RS01935	COG1785	Belongs to the alkaline phosphatase family
DOE78_RS01950	COG2224	Isocitrate lyase
DOE78_RS01955	COG5506	Protein of unknown function (DUF1694)
DOE78_RS01960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DOE78_RS01965	COG0154	amidase activity
DOE78_RS01970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DOE78_RS01985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DOE78_RS01995	COG1597	lipid kinase activity
DOE78_RS02005	COG0288	reversible hydration of carbon dioxide
DOE78_RS02015	COG5609	conserved protein (DUF2294)
DOE78_RS02035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DOE78_RS02090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DOE78_RS02095	COG1454	alcohol dehydrogenase
DOE78_RS02105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DOE78_RS02135	COG0765	amino acid transport
DOE78_RS02140	COG1126	abc transporter atp-binding protein
DOE78_RS02155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOE78_RS02180	COG0697	spore germination
DOE78_RS02205	COG0789	Transcriptional regulator
DOE78_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS02215	COG2249	NAD(P)H dehydrogenase (quinone) activity
DOE78_RS02230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOE78_RS02230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOE78_RS02240	COG0456	acetyltransferase
DOE78_RS02255	COG1522	sequence-specific DNA binding
DOE78_RS02260	COG0584	glycerophosphoryl diester phosphodiesterase
DOE78_RS02265	COG3973	AAA domain
DOE78_RS02275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOE78_RS02280	COG0640	Transcriptional regulator
DOE78_RS02285	COG0300	oxidoreductase activity
DOE78_RS02295	COG2755	lipolytic protein G-D-S-L family
DOE78_RS02305	COG0596	Alpha beta hydrolase
DOE78_RS02310	COG1309	transcriptional regulator
DOE78_RS02325	COG0662	Cupin 2, conserved barrel domain protein
DOE78_RS02340	COG2323	membrane
DOE78_RS02345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DOE78_RS02360	COG2807	transmembrane transport
DOE78_RS02380	COG0697	spore germination
DOE78_RS02390	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DOE78_RS02410	COG1621	beta-fructofuranosidase activity
DOE78_RS02415	COG1621	beta-fructofuranosidase activity
DOE78_RS02420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOE78_RS02420	COG1263	PTS System
DOE78_RS02425	COG3711	transcriptional antiterminator
DOE78_RS02430	COG0778	Nitroreductase
DOE78_RS02480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DOE78_RS02490	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS02490	COG3347	Dehydrogenase
DOE78_RS02515	COG2972	Histidine kinase
DOE78_RS02520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DOE78_RS02520	COG2207	Transcriptional regulator
DOE78_RS02525	COG1129	ABC transporter
DOE78_RS02530	COG1172	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS02535	COG1172	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS02545	COG3408	Glycogen debranching enzyme
DOE78_RS02550	COG0662	Cupin 2, conserved barrel domain protein
DOE78_RS02550	COG2207	Transcriptional regulator
DOE78_RS02555	COG2211	Major facilitator Superfamily
DOE78_RS02560	COG3250	beta-galactosidase activity
DOE78_RS02565	COG2972	Histidine kinase
DOE78_RS02570	COG4753	response regulator
DOE78_RS02570	COG2207	Transcriptional regulator
DOE78_RS02580	COG1175	transmembrane transport
DOE78_RS02585	COG0395	ABC-type sugar transport system, permease component
DOE78_RS02590	COG3408	Glycogen debranching enzyme
DOE78_RS02600	COG1940	carbohydrate kinase activity
DOE78_RS02605	COG0668	transmembrane transport
DOE78_RS02615	COG1942	4-Oxalocrotonate Tautomerase
DOE78_RS02630	COG4684	Psort location CytoplasmicMembrane, score
DOE78_RS02640	COG1070	Carbohydrate kinase
DOE78_RS02645	COG4806	L-rhamnose isomerase
DOE78_RS02650	COG1349	DNA-binding transcription factor activity
DOE78_RS02655	COG0745	RESPONSE REGULATOR receiver
DOE78_RS02660	COG3850	Histidine kinase
DOE78_RS02660	COG5002	protein histidine kinase activity
DOE78_RS02675	COG0577	efflux transmembrane transporter activity
DOE78_RS02675	COG1136	(ABC) transporter
DOE78_RS02680	COG0577	efflux transmembrane transporter activity
DOE78_RS02695	COG1454	alcohol dehydrogenase
DOE78_RS02705	COG2801	Transposase and inactivated derivatives
DOE78_RS02720	COG0667	Aldo Keto reductase
DOE78_RS02725	COG2207	Transcriptional regulator
DOE78_RS02735	COG1064	alcohol dehydrogenase
DOE78_RS02740	COG0789	Transcriptional regulator
DOE78_RS02745	COG3275	phosphorelay sensor kinase activity
DOE78_RS02760	COG4209	transmembrane transport
DOE78_RS02765	COG0395	ABC-type sugar transport system, permease component
DOE78_RS02780	COG0577	efflux transmembrane transporter activity
DOE78_RS02785	COG1136	(ABC) transporter
DOE78_RS02790	COG0642	Histidine kinase
DOE78_RS02795	COG0745	RESPONSE REGULATOR receiver
DOE78_RS02805	COG1231	oxidoreductase activity
DOE78_RS02825	COG0583	DNA-binding transcription factor activity
DOE78_RS02830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DOE78_RS02845	COG2814	Major facilitator Superfamily
DOE78_RS02850	COG0745	RESPONSE REGULATOR receiver
DOE78_RS02855	COG3850	Histidine kinase
DOE78_RS02855	COG5002	protein histidine kinase activity
DOE78_RS02860	COG1136	(ABC) transporter
DOE78_RS02865	COG0577	efflux transmembrane transporter activity
DOE78_RS02865	COG1136	(ABC) transporter
DOE78_RS02870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOE78_RS02875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOE78_RS02880	COG0716	FMN binding
DOE78_RS02885	COG4585	Histidine kinase
DOE78_RS02890	COG2197	response regulator
DOE78_RS02895	COG1131	(ABC) transporter
DOE78_RS02900	COG0842	Transport permease protein
DOE78_RS02900	COG1511	domain protein
DOE78_RS02905	COG0842	Transport permease protein
DOE78_RS02955	COG4191	Histidine kinase
DOE78_RS02970	COG1114	Component of the transport system for branched-chain amino acids
DOE78_RS02980	COG0768	penicillin binding
DOE78_RS03005	COG1131	(ABC) transporter
DOE78_RS03020	COG0326	Molecular chaperone. Has ATPase activity
DOE78_RS03030	COG5434	Belongs to the glycosyl hydrolase 28 family
DOE78_RS03040	COG2154	pterin-4-alpha-carbinolamine dehydratase
DOE78_RS03045	COG2814	Major facilitator Superfamily
DOE78_RS03050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DOE78_RS03065	COG3239	Fatty acid desaturase
DOE78_RS03070	COG1970	mechanosensitive ion channel activity
DOE78_RS03080	COG0681	Belongs to the peptidase S26 family
DOE78_RS03085	COG0531	amino acid
DOE78_RS03090	COG1126	abc transporter atp-binding protein
DOE78_RS03095	COG0765	amino acid transport
DOE78_RS03100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOE78_RS03115	COG0166	Belongs to the GPI family
DOE78_RS03120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOE78_RS03125	COG0765	amino acid transport
DOE78_RS03130	COG1126	abc transporter atp-binding protein
DOE78_RS03140	COG2966	Psort location CytoplasmicMembrane, score
DOE78_RS03160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DOE78_RS03165	COG0697	spore germination
DOE78_RS03180	COG0154	amidase activity
DOE78_RS03200	COG0723	plastoquinol--plastocyanin reductase activity
DOE78_RS03200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DOE78_RS03205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DOE78_RS03210	COG2340	Cysteine-rich secretory protein family
DOE78_RS03225	COG4758	membrane
DOE78_RS03230	COG4585	Histidine kinase
DOE78_RS03235	COG2197	response regulator
DOE78_RS03240	COG0488	(ABC) transporter
DOE78_RS03245	COG2244	polysaccharide biosynthetic process
DOE78_RS03255	COG1278	Cold shock
DOE78_RS03265	COG1309	transcriptional regulator
DOE78_RS03270	COG0673	inositol 2-dehydrogenase activity
DOE78_RS03280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DOE78_RS03285	COG0840	transmembrane signaling receptor activity
DOE78_RS03290	COG3541	Predicted nucleotidyltransferase
DOE78_RS03300	COG2318	DinB family
DOE78_RS03305	COG1136	(ABC) transporter
DOE78_RS03310	COG0577	efflux transmembrane transporter activity
DOE78_RS03320	COG0745	RESPONSE REGULATOR receiver
DOE78_RS03325	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOE78_RS03330	COG4605	iron ion homeostasis
DOE78_RS03335	COG4604	ABC transporter, ATP-binding protein
DOE78_RS03340	COG4607	ABC-type enterochelin transport system periplasmic component
DOE78_RS03345	COG2329	Antibiotic biosynthesis monooxygenase
DOE78_RS03350	COG2323	membrane
DOE78_RS03365	COG2309	aminopeptidase activity
DOE78_RS03385	COG0450	alkyl hydroperoxide reductase
DOE78_RS03395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DOE78_RS03400	COG1360	Flagellar Motor Protein
DOE78_RS03405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS03405	COG1522	sequence-specific DNA binding
DOE78_RS03410	COG2313	pseudouridylate synthase activity
DOE78_RS03425	COG1396	sequence-specific DNA binding
DOE78_RS03430	COG0024	Methionine aminopeptidase
DOE78_RS03445	COG4840	Belongs to the UPF0435 family
DOE78_RS03450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DOE78_RS03460	COG1295	ribonuclease BN
DOE78_RS03465	COG2217	Heavy metal translocating P-type atpase
DOE78_RS03470	COG0477	Major facilitator Superfamily
DOE78_RS03480	COG3871	stress protein (general stress protein 26)
DOE78_RS03485	COG0387	Pfam Sodium calcium exchanger
DOE78_RS03500	COG0535	radical SAM domain protein
DOE78_RS03550	COG4974	Belongs to the 'phage' integrase family
DOE78_RS03570	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DOE78_RS03575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOE78_RS03580	COG4807	Protein conserved in bacteria
DOE78_RS03590	COG1175	transmembrane transport
DOE78_RS03610	COG2972	Histidine kinase
DOE78_RS03615	COG4753	response regulator
DOE78_RS03615	COG2207	Transcriptional regulator
DOE78_RS03625	COG0300	oxidoreductase activity
DOE78_RS03630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DOE78_RS03635	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DOE78_RS03645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DOE78_RS03650	COG0604	alcohol dehydrogenase
DOE78_RS03655	COG1733	regulation of RNA biosynthetic process
DOE78_RS03670	COG0697	spore germination
DOE78_RS03675	COG0488	(ABC) transporter
DOE78_RS03695	COG3835	regulator
DOE78_RS03700	COG2610	gluconate transmembrane transporter activity
DOE78_RS03705	COG1929	Belongs to the glycerate kinase type-1 family
DOE78_RS03710	COG1120	ATPase activity
DOE78_RS03715	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DOE78_RS03720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOE78_RS03725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOE78_RS03740	COG5002	protein histidine kinase activity
DOE78_RS03745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DOE78_RS03750	COG5002	protein histidine kinase activity
DOE78_RS03755	COG0745	RESPONSE REGULATOR receiver
DOE78_RS03770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE78_RS03775	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS03780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DOE78_RS03815	COG2203	Gaf domain
DOE78_RS03815	COG2199	diguanylate cyclase activity
DOE78_RS03830	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DOE78_RS03840	COG1070	Carbohydrate kinase
DOE78_RS03860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DOE78_RS03895	COG4303	Ethanolamine ammonia lyase large subunit
DOE78_RS03900	COG4302	ethanolamine ammonia-lyase activity
DOE78_RS03905	COG3192	ethanolamine utilization protein
DOE78_RS03920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DOE78_RS03930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DOE78_RS03935	COG2133	pyrroloquinoline quinone binding
DOE78_RS03940	COG2801	Transposase and inactivated derivatives
DOE78_RS03945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DOE78_RS03955	COG2182	Extracellular solute-binding protein
DOE78_RS03960	COG1175	transmembrane transport
DOE78_RS03965	COG3833	ABC-type maltose transport systems, permease component
DOE78_RS03970	COG1874	Beta-galactosidase
DOE78_RS03975	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DOE78_RS03980	COG1609	Transcriptional regulator
DOE78_RS03995	COG1834	amidinotransferase
DOE78_RS04000	COG3708	Transcriptional regulator
DOE78_RS04000	COG2207	Transcriptional regulator
DOE78_RS04010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DOE78_RS04025	COG0385	Bile acid
DOE78_RS04075	COG0640	Transcriptional regulator
DOE78_RS04080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DOE78_RS04095	COG1764	response to oxidative stress
DOE78_RS04100	COG1846	Transcriptional regulator
DOE78_RS04110	COG4989	oxidoreductase activity
DOE78_RS04125	COG2169	Transcriptional regulator
DOE78_RS04130	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DOE78_RS04135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DOE78_RS04140	COG1404	Belongs to the peptidase S8 family
DOE78_RS04145	COG0716	FMN binding
DOE78_RS04155	COG0716	FMN binding
DOE78_RS04160	COG4213	ABC transporter substrate-binding protein
DOE78_RS04165	COG1129	ABC transporter
DOE78_RS04170	COG4214	carbohydrate transport
DOE78_RS04180	COG2972	Histidine kinase
DOE78_RS04185	COG2197	response regulator
DOE78_RS04190	COG4213	ABC transporter substrate-binding protein
DOE78_RS04195	COG1595	DNA-templated transcription, initiation
DOE78_RS04215	COG0426	domain, Protein
DOE78_RS04230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOE78_RS04245	COG1113	amino acid transport
DOE78_RS04280	COG2814	Major facilitator Superfamily
DOE78_RS04285	COG3480	Lon protease (S16) C-terminal proteolytic domain
DOE78_RS04310	COG1609	Transcriptional regulator
DOE78_RS04325	COG0395	ABC-type sugar transport system, permease component
DOE78_RS04330	COG3507	Belongs to the glycosyl hydrolase 43 family
DOE78_RS04335	COG3507	Belongs to the glycosyl hydrolase 43 family
DOE78_RS04345	COG1069	ribulokinase activity
DOE78_RS04365	COG3534	alpha-L-arabinofuranosidase
DOE78_RS04390	COG3940	Belongs to the glycosyl hydrolase 43 family
DOE78_RS04395	COG3940	Belongs to the glycosyl hydrolase 43 family
DOE78_RS04400	COG0534	Mate efflux family protein
DOE78_RS04415	COG1388	LysM domain
DOE78_RS04415	COG3584	3D domain protein
DOE78_RS04430	COG2814	Major facilitator Superfamily
DOE78_RS04435	COG1309	transcriptional regulator
DOE78_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS04455	COG2814	Major facilitator Superfamily
DOE78_RS04460	COG0640	Transcriptional regulator
DOE78_RS04475	COG2962	Rard protein
DOE78_RS04500	COG1376	ErfK ybiS ycfS ynhG family protein
DOE78_RS04540	COG2211	Major facilitator Superfamily
DOE78_RS04550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DOE78_RS04575	COG0384	phenazine biosynthesis protein PhzF
DOE78_RS04585	COG1280	lysine exporter protein (LysE YggA)
DOE78_RS04595	COG0454	-acetyltransferase
DOE78_RS04605	COG3300	MHYT domain
DOE78_RS04605	COG5001	Diguanylate cyclase
DOE78_RS04615	COG3845	ABC transporter
DOE78_RS04620	COG4603	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS04625	COG1079	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS04630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DOE78_RS04655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOE78_RS04660	COG0765	amino acid transport
DOE78_RS04665	COG1126	abc transporter atp-binding protein
DOE78_RS04670	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DOE78_RS04675	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS04680	COG2731	YhcH YjgK YiaL family protein
DOE78_RS04690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS04695	COG1414	Transcriptional regulator
DOE78_RS04700	COG0800	Aldolase
DOE78_RS04705	COG3546	catalase activity
DOE78_RS04715	COG0833	amino acid
DOE78_RS04720	COG2040	homocysteine
DOE78_RS04740	COG0577	efflux transmembrane transporter activity
DOE78_RS04740	COG1136	(ABC) transporter
DOE78_RS04745	COG1136	(ABC) transporter
DOE78_RS04755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DOE78_RS04760	COG4191	Histidine kinase
DOE78_RS04775	COG0789	Transcriptional regulator
DOE78_RS04785	COG1664	Polymer-forming cytoskeletal
DOE78_RS04805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOE78_RS04810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DOE78_RS04825	COG2226	methyltransferase
DOE78_RS04830	COG0681	Belongs to the peptidase S26 family
DOE78_RS04835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOE78_RS04840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOE78_RS04845	COG1116	anion transmembrane transporter activity
DOE78_RS04860	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DOE78_RS04875	COG1695	Transcriptional regulator
DOE78_RS04885	COG2824	Alkylphosphonate utilization operon protein PhnA
DOE78_RS04895	COG1278	Cold shock
DOE78_RS04900	COG0840	transmembrane signaling receptor activity
DOE78_RS04925	COG0004	ammonium transporteR
DOE78_RS04955	COG0300	oxidoreductase activity
DOE78_RS04960	COG2222	sugar isomerase
DOE78_RS04965	COG1653	transport
DOE78_RS04970	COG1175	transmembrane transport
DOE78_RS04975	COG0395	ABC-type sugar transport system, permease component
DOE78_RS04980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS04985	COG2188	Transcriptional regulator
DOE78_RS04990	COG2223	nitrite transmembrane transporter activity
DOE78_RS04995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DOE78_RS05000	COG0243	molybdopterin cofactor binding
DOE78_RS05005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DOE78_RS05010	COG2146	nitrite reductase [NAD(P)H] activity
DOE78_RS05020	COG3314	Sporulation integral membrane protein YlbJ
DOE78_RS05025	COG1473	amidohydrolase
DOE78_RS05035	COG4948	Mandelate Racemase Muconate Lactonizing
DOE78_RS05045	COG4895	conserved protein (DUF2196)
DOE78_RS05055	COG1271	oxidase subunit
DOE78_RS05060	COG1294	oxidase, subunit
DOE78_RS05065	COG4988	ABC transporter
DOE78_RS05070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DOE78_RS05080	COG0840	transmembrane signaling receptor activity
DOE78_RS05085	COG2270	Major facilitator Superfamily
DOE78_RS05100	COG2195	Cleaves the N-terminal amino acid of tripeptides
DOE78_RS05115	COG1090	epimerase
DOE78_RS05125	COG4221	oxidoreductase activity
DOE78_RS05145	COG1988	membrane-bound metal-dependent
DOE78_RS05150	COG1194	a g-specific adenine glycosylase
DOE78_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS05180	COG1132	(ABC) transporter
DOE78_RS05185	COG0444	Belongs to the ABC transporter superfamily
DOE78_RS05190	COG4608	Belongs to the ABC transporter superfamily
DOE78_RS05195	COG0747	negative chemotaxis
DOE78_RS05200	COG0601	transmembrane transport
DOE78_RS05205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOE78_RS05210	COG4129	membrane
DOE78_RS05215	COG0067	glutamate synthase
DOE78_RS05215	COG0069	glutamate synthase activity
DOE78_RS05215	COG0070	glutamate synthase
DOE78_RS05220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DOE78_RS05225	COG4555	ABC transporter
DOE78_RS05245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DOE78_RS05250	COG2096	Adenosyltransferase
DOE78_RS05255	COG0735	belongs to the Fur family
DOE78_RS05375	COG1733	regulation of RNA biosynthetic process
DOE78_RS05380	COG2814	Major facilitator Superfamily
DOE78_RS05385	COG0656	L-ascorbic acid biosynthetic process
DOE78_RS05390	COG3382	B3 4 domain protein
DOE78_RS05410	COG0778	Nitroreductase
DOE78_RS05415	COG2766	serine protein kinase
DOE78_RS05425	COG2718	Belongs to the UPF0229 family
DOE78_RS05430	COG0561	phosphatase activity
DOE78_RS05445	COG1408	metallophosphoesterase
DOE78_RS05455	COG1587	Uroporphyrinogen-III synthase
DOE78_RS05460	COG0494	nUDIX hydrolase
DOE78_RS05470	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS05480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DOE78_RS05495	COG1215	transferase activity, transferring glycosyl groups
DOE78_RS05505	COG0745	RESPONSE REGULATOR receiver
DOE78_RS05510	COG5002	protein histidine kinase activity
DOE78_RS05515	COG0564	pseudouridine synthase activity
DOE78_RS05525	COG3118	belongs to the thioredoxin family
DOE78_RS05535	COG1309	transcriptional regulator
DOE78_RS05540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOE78_RS05565	COG2719	SpoVR family
DOE78_RS05570	COG4990	cell redox homeostasis
DOE78_RS05575	COG0861	Integral membrane protein TerC family
DOE78_RS05680	COG0745	RESPONSE REGULATOR receiver
DOE78_RS05685	COG5002	protein histidine kinase activity
DOE78_RS05685	COG3850	Histidine kinase
DOE78_RS05690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOE78_RS05705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOE78_RS05710	COG1253	flavin adenine dinucleotide binding
DOE78_RS05715	COG0789	Transcriptional regulator
DOE78_RS05720	COG3852	Histidine kinase
DOE78_RS05740	COG1476	TRANSCRIPTIONal
DOE78_RS05750	COG2814	Major facilitator Superfamily
DOE78_RS05755	COG1132	(ABC) transporter
DOE78_RS05760	COG1132	(ABC) transporter
DOE78_RS05775	COG3842	ATPase activity
DOE78_RS05780	COG2508	Transcriptional regulator
DOE78_RS05785	COG1937	Protein conserved in bacteria
DOE78_RS05790	COG0189	ligase activity
DOE78_RS05795	COG0189	ligase activity
DOE78_RS05800	COG0189	ligase activity
DOE78_RS05805	COG0189	ligase activity
DOE78_RS05820	COG0561	phosphatase activity
DOE78_RS05825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DOE78_RS05835	COG1024	Enoyl-CoA hydratase
DOE78_RS05840	COG4152	abc transporter atp-binding protein
DOE78_RS05845	COG1668	transmembrane transport
DOE78_RS05850	COG0420	3'-5' exonuclease activity
DOE78_RS05855	COG4717	serine-type aminopeptidase activity
DOE78_RS05860	COG3481	metal-dependent phosphohydrolase, HD sub domain
DOE78_RS05870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOE78_RS05900	COG1846	Transcriptional regulator
DOE78_RS05920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DOE78_RS05925	COG0537	adenosine 5'-monophosphoramidase activity
DOE78_RS05930	COG1131	(ABC) transporter
DOE78_RS05935	COG4473	ABC transporter
DOE78_RS05950	COG1473	amidohydrolase
DOE78_RS05955	COG2706	6-phosphogluconolactonase activity
DOE78_RS05960	COG3711	transcriptional antiterminator
DOE78_RS05960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOE78_RS05965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS05970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS05975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS05980	COG1447	Phosphotransferase system cellobiose-specific component IIA
DOE78_RS05985	COG2723	6-phospho-beta-galactosidase activity
DOE78_RS05995	COG0561	phosphatase activity
DOE78_RS06000	COG3069	C4-dicarboxylate transmembrane transporter activity
DOE78_RS06010	COG4585	Histidine kinase
DOE78_RS06015	COG2197	response regulator
DOE78_RS06020	COG2329	Antibiotic biosynthesis monooxygenase
DOE78_RS06025	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DOE78_RS06030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DOE78_RS06035	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DOE78_RS06040	COG1309	transcriptional regulator
DOE78_RS06045	COG1511	domain protein
DOE78_RS06055	COG1234	tRNA 3'-trailer cleavage
DOE78_RS06060	COG0095	Lipoate-protein ligase
DOE78_RS06065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DOE78_RS06070	COG5577	PFAM Coat F domain
DOE78_RS06080	COG0318	PFAM AMP-dependent synthetase and ligase
DOE78_RS06085	COG1024	Enoyl-CoA hydratase
DOE78_RS06100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DOE78_RS06105	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DOE78_RS06115	COG0501	Belongs to the peptidase M48B family
DOE78_RS06125	COG4903	ComK protein
DOE78_RS06135	COG0823	Involved in the tonB-independent uptake of proteins
DOE78_RS06135	COG1506	peptidase
DOE78_RS06135	COG4946	Tricorn protease homolog
DOE78_RS06140	COG0398	Pfam SNARE associated Golgi protein
DOE78_RS06145	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS06150	COG0596	Alpha beta hydrolase
DOE78_RS06155	COG1349	DNA-binding transcription factor activity
DOE78_RS06160	COG0561	phosphatase activity
DOE78_RS06165	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DOE78_RS06175	COG1403	HNH endonuclease
DOE78_RS06210	COG0318	PFAM AMP-dependent synthetase and ligase
DOE78_RS06215	COG2311	Membrane
DOE78_RS06220	COG0179	Fumarylacetoacetate (FAA) hydrolase
DOE78_RS06235	COG0367	asparagine synthase
DOE78_RS06250	COG1562	ergosterol biosynthetic process
DOE78_RS06255	COG0534	Mate efflux family protein
DOE78_RS06265	COG2182	Extracellular solute-binding protein
DOE78_RS06270	COG1175	transmembrane transport
DOE78_RS06275	COG3833	ABC-type maltose transport systems, permease component
DOE78_RS06285	COG1609	Transcriptional regulator
DOE78_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS06295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DOE78_RS06300	COG2223	nitrite transmembrane transporter activity
DOE78_RS06305	COG5609	conserved protein (DUF2294)
DOE78_RS06310	COG3383	formate dehydrogenase (NAD+) activity
DOE78_RS06315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DOE78_RS06320	COG1280	lysine exporter protein (LysE YggA)
DOE78_RS06335	COG0583	DNA-binding transcription factor activity
DOE78_RS06340	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS06350	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS06355	COG1556	Lactate utilization protein
DOE78_RS06360	COG1139	Iron-sulfur cluster binding protein
DOE78_RS06365	COG0247	lactate metabolic process
DOE78_RS06370	COG2186	Transcriptional regulator
DOE78_RS06375	COG1666	GTP binding
DOE78_RS06380	COG2996	Protein conserved in bacteria
DOE78_RS06390	COG1307	EDD domain protein, DegV family
DOE78_RS06395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOE78_RS06410	COG0561	phosphatase activity
DOE78_RS06415	COG1073	alpha beta
DOE78_RS06420	COG2151	metal-sulfur cluster biosynthetic enzyme
DOE78_RS06425	COG0535	radical SAM domain protein
DOE78_RS06430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOE78_RS06435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DOE78_RS06440	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DOE78_RS06445	COG0303	'Molybdopterin
DOE78_RS06450	COG1763	Mo-molybdopterin cofactor biosynthetic process
DOE78_RS06460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOE78_RS06465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DOE78_RS06470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DOE78_RS06475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DOE78_RS06495	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DOE78_RS06505	COG0542	response to heat
DOE78_RS06515	COG2267	carboxylic ester hydrolase activity
DOE78_RS06525	COG1744	ABC transporter substrate-binding protein PnrA-like
DOE78_RS06540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOE78_RS06545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DOE78_RS06550	COG5504	Zn-dependent protease
DOE78_RS06555	COG0444	Belongs to the ABC transporter superfamily
DOE78_RS06560	COG4608	Belongs to the ABC transporter superfamily
DOE78_RS06570	COG0601	transmembrane transport
DOE78_RS06575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOE78_RS06590	COG0180	Tryptophanyl-tRNA synthetase
DOE78_RS06600	COG4166	transmembrane transport
DOE78_RS06605	COG0601	transmembrane transport
DOE78_RS06610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOE78_RS06615	COG0444	Belongs to the ABC transporter superfamily
DOE78_RS06620	COG4608	Belongs to the ABC transporter superfamily
DOE78_RS06630	COG0456	acetyltransferase
DOE78_RS06635	COG1393	Belongs to the ArsC family
DOE78_RS06640	COG4862	establishment of competence for transformation
DOE78_RS06645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOE78_RS06655	COG1164	Oligoendopeptidase f
DOE78_RS06660	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DOE78_RS06665	COG2346	COG2346, Truncated hemoglobins
DOE78_RS06670	COG0741	lytic transglycosylase activity
DOE78_RS06675	COG4116	CYTH
DOE78_RS06685	COG2357	RelA SpoT domain protein
DOE78_RS06695	COG0564	pseudouridine synthase activity
DOE78_RS06705	COG2239	Acts as a magnesium transporter
DOE78_RS06710	COG0475	glutathione-regulated potassium exporter activity
DOE78_RS06710	COG0569	domain protein
DOE78_RS06715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DOE78_RS06720	COG2200	EAL domain
DOE78_RS06735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOE78_RS06755	COG0210	DNA helicase
DOE78_RS06765	COG2153	protein acetylation
DOE78_RS06770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DOE78_RS06775	COG2382	esterase
DOE78_RS06780	COG2358	TRAP transporter, solute receptor (TAXI family
DOE78_RS06835	COG1272	protein, Hemolysin III
DOE78_RS06845	COG0004	ammonium transporteR
DOE78_RS06855	COG2176	DNA-directed DNA polymerase activity
DOE78_RS06860	COG0460	homoserine dehydrogenase
DOE78_RS06870	COG1063	alcohol dehydrogenase
DOE78_RS06880	COG0628	permease
DOE78_RS06905	COG0084	hydrolase, TatD family'
DOE78_RS06910	COG1116	anion transmembrane transporter activity
DOE78_RS06915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOE78_RS06925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DOE78_RS06935	COG2203	Gaf domain
DOE78_RS06935	COG3706	GGDEF domain
DOE78_RS06935	COG4251	negative regulation of phosphorylation
DOE78_RS06935	COG5001	Diguanylate cyclase
DOE78_RS06940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOE78_RS06955	COG1191	sigma factor activity
DOE78_RS06980	COG3594	Acyltransferase
DOE78_RS06985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DOE78_RS06990	COG0674	pyruvate-flavodoxin oxidoreductase activity
DOE78_RS06995	COG0840	transmembrane signaling receptor activity
DOE78_RS07000	COG5002	protein histidine kinase activity
DOE78_RS07005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DOE78_RS07010	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DOE78_RS07015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DOE78_RS07020	COG0436	Aminotransferase
DOE78_RS07025	COG1850	ribulose-bisphosphate carboxylase activity
DOE78_RS07030	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DOE78_RS07035	COG0235	Class ii aldolase
DOE78_RS07040	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DOE78_RS07050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOE78_RS07065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DOE78_RS07070	COG0644	oxidoreductase
DOE78_RS07095	COG2223	nitrite transmembrane transporter activity
DOE78_RS07100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DOE78_RS07105	COG3852	Histidine kinase
DOE78_RS07110	COG1846	Transcriptional regulator
DOE78_RS07120	COG0542	response to heat
DOE78_RS07145	COG4873	Protein conserved in bacteria
DOE78_RS07155	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS07165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOE78_RS07185	COG2084	Dehydrogenase
DOE78_RS07190	COG0436	Aminotransferase
DOE78_RS07200	COG0784	Response regulator, receiver
DOE78_RS07200	COG0835	chemotaxis
DOE78_RS07210	COG0248	Ppx GppA phosphatase
DOE78_RS07220	COG5001	Diguanylate cyclase
DOE78_RS07220	COG3300	MHYT domain
DOE78_RS07225	COG1408	metallophosphoesterase
DOE78_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS07235	COG4990	cell redox homeostasis
DOE78_RS07240	COG2200	EAL domain
DOE78_RS07265	COG4703	Protein of unknown function (DUF1797)
DOE78_RS07270	COG0517	IMP dehydrogenase activity
DOE78_RS07275	COG0583	DNA-binding transcription factor activity
DOE78_RS07280	COG2171	N-acyltransferase activity
DOE78_RS07285	COG1473	amidohydrolase
DOE78_RS07290	COG0450	alkyl hydroperoxide reductase
DOE78_RS07295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOE78_RS07300	COG1132	(ABC) transporter
DOE78_RS07305	COG1132	(ABC) transporter
DOE78_RS07310	COG0569	domain protein
DOE78_RS07315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DOE78_RS07320	COG5503	Protein of unknown function (DUF1447)
DOE78_RS07325	COG0242	peptide deformylase activity
DOE78_RS07340	COG0022	dehydrogenase e1 component
DOE78_RS07345	COG0508	dehydrogenase complex catalyzes the overall conversion of
DOE78_RS07380	COG1982	Orn Lys Arg decarboxylase major
DOE78_RS07385	COG4476	Belongs to the UPF0223 family
DOE78_RS07390	COG4493	Belongs to the UPF0637 family
DOE78_RS07400	COG0483	inositol monophosphate 1-phosphatase activity
DOE78_RS07415	COG1217	gtp-binding protein TYPA
DOE78_RS07430	COG4896	Protein conserved in bacteria
DOE78_RS07445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DOE78_RS07450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DOE78_RS07455	COG4838	Belongs to the UPF0358 family
DOE78_RS07460	COG0772	Belongs to the SEDS family
DOE78_RS07465	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DOE78_RS07470	COG1612	heme a metabolic process
DOE78_RS07500	COG3336	cytochrome c oxidase
DOE78_RS07515	COG0628	permease
DOE78_RS07530	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DOE78_RS07535	COG2340	Cysteine-rich secretory protein family
DOE78_RS07565	COG3679	Belongs to the UPF0342 family
DOE78_RS07570	COG4471	UPF0298 protein
DOE78_RS07585	COG0742	ribosomal rna small subunit methyltransferase
DOE78_RS07590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DOE78_RS07595	COG3314	Sporulation integral membrane protein YlbJ
DOE78_RS07600	COG1752	Esterase of the alpha-beta hydrolase superfamily
DOE78_RS07605	COG3480	Lon protease (S16) C-terminal proteolytic domain
DOE78_RS07610	COG1323	Belongs to the UPF0348 family
DOE78_RS07615	COG1399	metal-binding, possibly nucleic acid-binding protein
DOE78_RS07620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DOE78_RS07625	COG1024	Enoyl-CoA hydratase
DOE78_RS07635	COG0454	-acetyltransferase
DOE78_RS07640	COG0439	Biotin carboxylase
DOE78_RS07645	COG0511	ligase activity, forming carbon-carbon bonds
DOE78_RS07650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DOE78_RS07655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DOE78_RS07665	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DOE78_RS07675	COG2001	Belongs to the MraZ family
DOE78_RS07680	COG0275	rRNA processing
DOE78_RS07685	COG4839	cell division protein FtsL
DOE78_RS07690	COG0768	penicillin binding
DOE78_RS07695	COG0768	penicillin binding
DOE78_RS07700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DOE78_RS07705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DOE78_RS07710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DOE78_RS07715	COG0772	Belongs to the SEDS family
DOE78_RS07720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DOE78_RS07725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DOE78_RS07730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DOE78_RS07735	COG3879	Bacterial protein of unknown function (DUF881)
DOE78_RS07740	COG3879	Bacterial protein of unknown function (DUF881)
DOE78_RS07745	COG3856	small basic protein
DOE78_RS07750	COG0849	cell division
DOE78_RS07755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DOE78_RS07765	COG1191	sigma factor activity
DOE78_RS07770	COG1191	sigma factor activity
DOE78_RS07775	COG1873	PFAM PRC-barrel domain
DOE78_RS07785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DOE78_RS07790	COG1799	cell septum assembly
DOE78_RS07795	COG0762	integral membrane protein
DOE78_RS07800	COG2302	S4 RNA-binding domain
DOE78_RS07805	COG3599	regulation of cell shape
DOE78_RS07815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DOE78_RS07820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DOE78_RS07825	COG0564	pseudouridine synthase activity
DOE78_RS07830	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DOE78_RS07840	COG0540	Belongs to the ATCase OTCase family
DOE78_RS07845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DOE78_RS07855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DOE78_RS07860	COG0543	2 iron, 2 sulfur cluster binding
DOE78_RS07865	COG0167	dihydroorotate dehydrogenase activity
DOE78_RS07870	COG0284	orotidine-5'-phosphate decarboxylase activity
DOE78_RS07885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DOE78_RS07890	COG1561	YicC-like family, N-terminal region
DOE78_RS07895	COG2052	Domain of unknown function (DUF370)
DOE78_RS07900	COG0194	GDP metabolic process
DOE78_RS07910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DOE78_RS07915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DOE78_RS07920	COG0242	peptide deformylase activity
DOE78_RS07930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOE78_RS07930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DOE78_RS07935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DOE78_RS07940	COG0631	protein serine/threonine phosphatase activity
DOE78_RS07945	COG0515	serine threonine protein kinase
DOE78_RS07945	COG2815	serine threonine protein kinase
DOE78_RS07955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DOE78_RS07960	COG1564	THIamine pyrophosphokinase
DOE78_RS07970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DOE78_RS07975	COG1302	Protein conserved in bacteria
DOE78_RS07980	COG1461	Dihydroxyacetone kinase
DOE78_RS07985	COG1760	l-serine dehydratase
DOE78_RS07990	COG1760	l-serine dehydratase
DOE78_RS07995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DOE78_RS08000	COG1349	DNA-binding transcription factor activity
DOE78_RS08005	COG0416	fatty acid biosynthetic process
DOE78_RS08010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DOE78_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS08020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DOE78_RS08025	COG0571	ribonuclease III activity
DOE78_RS08030	COG1196	nuclear chromosome segregation
DOE78_RS08035	COG0552	protein localization to endoplasmic reticulum
DOE78_RS08040	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DOE78_RS08045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DOE78_RS08055	COG1837	Belongs to the UPF0109 family
DOE78_RS08065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DOE78_RS08070	COG0336	Belongs to the RNA methyltransferase TrmD family
DOE78_RS08075	COG0335	large ribosomal subunit rRNA binding
DOE78_RS08100	COG2257	FlhB HrpN YscU SpaS Family
DOE78_RS08110	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DOE78_RS08115	COG0758	DNA mediated transformation
DOE78_RS08120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DOE78_RS08125	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DOE78_RS08130	COG4974	Belongs to the 'phage' integrase family
DOE78_RS08140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DOE78_RS08145	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DOE78_RS08150	COG1815	bacterial-type flagellum-dependent cell motility
DOE78_RS08155	COG1558	bacterial-type flagellum-dependent cell motility
DOE78_RS08160	COG1677	Flagellar hook-basal body complex protein FliE
DOE78_RS08165	COG1766	The M ring may be actively involved in energy transduction
DOE78_RS08170	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DOE78_RS08175	COG1317	bacterial-type flagellum organization
DOE78_RS08180	COG1157	protein secretion by the type III secretion system
DOE78_RS08185	COG2882	bacterial-type flagellum organization
DOE78_RS08200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DOE78_RS08210	COG1749	Flagellar hook protein flgE
DOE78_RS08215	COG1582	Flagellar protein (FlbD)
DOE78_RS08220	COG1580	Controls the rotational direction of flagella during chemotaxis
DOE78_RS08225	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DOE78_RS08230	COG1776	CheC inhibitor of MCP methylation
DOE78_RS08230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DOE78_RS08235	COG2201	protein-glutamate methylesterase activity
DOE78_RS08240	COG3190	flagellar
DOE78_RS08245	COG1338	Plays a role in the flagellum-specific transport system
DOE78_RS08250	COG1987	bacterial-type flagellum assembly
DOE78_RS08255	COG1684	flagellar biosynthetic protein fliR
DOE78_RS08260	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DOE78_RS08265	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DOE78_RS08270	COG1419	protein localization to endoplasmic reticulum
DOE78_RS08275	COG0455	bacterial-type flagellum organization
DOE78_RS08280	COG2201	protein-glutamate methylesterase activity
DOE78_RS08285	COG0643	Histidine kinase
DOE78_RS08285	COG2198	Histidine kinase
DOE78_RS08290	COG0835	chemotaxis
DOE78_RS08295	COG1776	CheC inhibitor of MCP methylation
DOE78_RS08300	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DOE78_RS08305	COG1191	sigma factor activity
DOE78_RS08335	COG0233	cytoplasmic translational termination
DOE78_RS08345	COG4589	Belongs to the CDS family
DOE78_RS08350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DOE78_RS08355	COG0750	zinc metalloprotease
DOE78_RS08360	COG0442	prolyl-tRNA aminoacylation
DOE78_RS08365	COG2176	DNA-directed DNA polymerase activity
DOE78_RS08370	COG0779	Required for maturation of 30S ribosomal subunits
DOE78_RS08375	COG0195	Participates in both transcription termination and antitermination
DOE78_RS08380	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DOE78_RS08385	COG1358	cellular component organization or biogenesis
DOE78_RS08395	COG1550	Protein conserved in bacteria
DOE78_RS08400	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DOE78_RS08405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DOE78_RS08410	COG0196	riboflavin kinase activity
DOE78_RS08415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DOE78_RS08420	COG1185	polyribonucleotide nucleotidyltransferase activity
DOE78_RS08425	COG0726	polysaccharide deacetylase
DOE78_RS08430	COG0612	Peptidase, M16
DOE78_RS08435	COG1873	PFAM PRC-barrel domain
DOE78_RS08440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DOE78_RS08445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DOE78_RS08450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DOE78_RS08455	COG0527	aspartate kinase activity
DOE78_RS08465	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DOE78_RS08470	COG0740	serine-type endopeptidase activity
DOE78_RS08480	COG4980	gas vesicle protein
DOE78_RS08480	COG1674	ftsk spoiiie
DOE78_RS08485	COG2188	Transcriptional regulator
DOE78_RS08490	COG1744	ABC transporter substrate-binding protein PnrA-like
DOE78_RS08495	COG3845	ABC transporter
DOE78_RS08500	COG4603	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS08505	COG1079	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS08510	COG3706	GGDEF domain
DOE78_RS08515	COG0612	Peptidase, M16
DOE78_RS08520	COG0612	Peptidase, M16
DOE78_RS08525	COG0300	oxidoreductase activity
DOE78_RS08540	COG1426	Protein conserved in bacteria
DOE78_RS08545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DOE78_RS08550	COG1058	Belongs to the CinA family
DOE78_RS08550	COG1546	Belongs to the CinA family
DOE78_RS08555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DOE78_RS08565	COG1692	metallophosphoesterase
DOE78_RS08570	COG2359	stage V sporulation protein S
DOE78_RS08580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DOE78_RS08580	COG0674	pyruvate-flavodoxin oxidoreductase activity
DOE78_RS08585	COG1013	pyruvate-flavodoxin oxidoreductase activity
DOE78_RS08590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOE78_RS08595	COG4550	Control of competence regulator ComK, YlbF/YmcA
DOE78_RS08605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DOE78_RS08610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DOE78_RS08625	COG1077	Cell shape determining protein MreB Mrl
DOE78_RS08630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DOE78_RS08640	COG0464	growth
DOE78_RS08645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DOE78_RS08650	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DOE78_RS08655	COG0789	Transcriptional regulator
DOE78_RS08660	COG0174	glutamine synthetase
DOE78_RS08670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DOE78_RS08680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DOE78_RS08685	COG4224	UPF0291 protein
DOE78_RS08700	COG3763	UPF0154 protein
DOE78_RS08710	COG1132	(ABC) transporter
DOE78_RS08715	COG1132	(ABC) transporter
DOE78_RS08725	COG0785	Cytochrome C biogenesis protein
DOE78_RS08730	COG2201	protein-glutamate methylesterase activity
DOE78_RS08735	COG4846	Membrane protein involved in cytochrome C biogenesis
DOE78_RS08760	COG0515	serine threonine protein kinase
DOE78_RS08760	COG2815	serine threonine protein kinase
DOE78_RS08785	COG0515	serine threonine protein kinase
DOE78_RS08785	COG2815	serine threonine protein kinase
DOE78_RS08805	COG2972	Histidine kinase
DOE78_RS08815	COG1940	carbohydrate kinase activity
DOE78_RS08825	COG1175	transmembrane transport
DOE78_RS08875	COG0673	inositol 2-dehydrogenase activity
DOE78_RS08880	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DOE78_RS08890	COG2755	lipolytic protein G-D-S-L family
DOE78_RS08895	COG1874	Beta-galactosidase
DOE78_RS08900	COG3254	rhamnose metabolic process
DOE78_RS08905	COG1132	(ABC) transporter
DOE78_RS08910	COG1132	(ABC) transporter
DOE78_RS08915	COG2972	Histidine kinase
DOE78_RS08920	COG4753	response regulator
DOE78_RS08920	COG2207	Transcriptional regulator
DOE78_RS08925	COG1653	transport
DOE78_RS08930	COG1653	transport
DOE78_RS08935	COG1175	transmembrane transport
DOE78_RS08940	COG0395	ABC-type sugar transport system, permease component
DOE78_RS08945	COG5578	integral membrane protein
DOE78_RS08950	COG2755	lipolytic protein G-D-S-L family
DOE78_RS08950	COG0657	acetylesterase activity
DOE78_RS08955	COG2848	UPF0210 protein
DOE78_RS08960	COG3830	Belongs to the UPF0237 family
DOE78_RS08965	COG1879	ABC-type sugar transport system periplasmic component
DOE78_RS08970	COG1129	ABC transporter
DOE78_RS08975	COG1172	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS08980	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS08985	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DOE78_RS09020	COG2508	Transcriptional regulator
DOE78_RS09025	COG0657	acetylesterase activity
DOE78_RS09030	COG1250	3-hydroxyacyl-CoA dehydrogenase
DOE78_RS09035	COG1024	Enoyl-CoA hydratase
DOE78_RS09040	COG0318	PFAM AMP-dependent synthetase and ligase
DOE78_RS09050	COG1960	acyl-CoA dehydrogenase activity
DOE78_RS09055	COG0183	Belongs to the thiolase family
DOE78_RS09060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DOE78_RS09065	COG0022	dehydrogenase e1 component
DOE78_RS09070	COG0508	dehydrogenase complex catalyzes the overall conversion of
DOE78_RS09075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DOE78_RS09080	COG1063	alcohol dehydrogenase
DOE78_RS09085	COG3284	Transcriptional regulator
DOE78_RS09090	COG1609	Transcriptional regulator
DOE78_RS09095	COG4209	transmembrane transport
DOE78_RS09100	COG0395	ABC-type sugar transport system, permease component
DOE78_RS09105	COG1653	transport
DOE78_RS09110	COG1621	beta-fructofuranosidase activity
DOE78_RS09115	COG1621	beta-fructofuranosidase activity
DOE78_RS09120	COG1114	Component of the transport system for branched-chain amino acids
DOE78_RS09125	COG2070	2-Nitropropane dioxygenase
DOE78_RS09135	COG1959	2 iron, 2 sulfur cluster binding
DOE78_RS09140	COG0583	DNA-binding transcription factor activity
DOE78_RS09145	COG1917	Cupin 2, conserved barrel domain protein
DOE78_RS09155	COG0179	Fumarylacetoacetate (FAA) hydrolase
DOE78_RS09165	COG1960	acyl-CoA dehydrogenase activity
DOE78_RS09185	COG1414	Transcriptional regulator
DOE78_RS09190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DOE78_RS09210	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DOE78_RS09230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DOE78_RS09240	COG1942	4-Oxalocrotonate Tautomerase
DOE78_RS09245	COG3885	ferrous iron binding
DOE78_RS09245	COG2078	PFAM AMMECR1 domain protein
DOE78_RS09255	COG2188	Transcriptional regulator
DOE78_RS09260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS09265	COG1653	transport
DOE78_RS09270	COG1175	transmembrane transport
DOE78_RS09275	COG0395	ABC-type sugar transport system, permease component
DOE78_RS09280	COG1082	Xylose isomerase domain protein TIM barrel
DOE78_RS09320	COG3290	protein histidine kinase activity
DOE78_RS09325	COG4565	transcriptional regulatory protein
DOE78_RS09335	COG1119	ATPase activity
DOE78_RS09365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DOE78_RS09370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DOE78_RS09420	COG0179	Fumarylacetoacetate (FAA) hydrolase
DOE78_RS09430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DOE78_RS09435	COG0579	oxidoreductase
DOE78_RS09440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DOE78_RS09445	COG1737	Transcriptional regulator
DOE78_RS09450	COG2723	6-phospho-beta-galactosidase activity
DOE78_RS09460	COG3152	Membrane
DOE78_RS09465	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DOE78_RS09485	COG0456	acetyltransferase
DOE78_RS09490	COG2197	response regulator
DOE78_RS09500	COG2072	flavoprotein involved in K transport
DOE78_RS09510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DOE78_RS09520	COG0697	spore germination
DOE78_RS09530	COG0494	nUDIX hydrolase
DOE78_RS09545	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS09545	COG2202	Pas domain
DOE78_RS09550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOE78_RS09555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOE78_RS09560	COG1120	ATPase activity
DOE78_RS09575	COG0789	Transcriptional regulator
DOE78_RS09585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DOE78_RS09585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE78_RS09595	COG0463	Glycosyl transferase, family 2
DOE78_RS09640	COG0477	Major facilitator Superfamily
DOE78_RS09645	COG0778	Nitroreductase
DOE78_RS09655	COG1216	Glycosyl transferase, family 2
DOE78_RS09660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE78_RS09665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE78_RS09685	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS09695	COG0463	Glycosyl transferase, family 2
DOE78_RS09710	COG0640	Transcriptional regulator
DOE78_RS09715	COG3832	glyoxalase III activity
DOE78_RS09745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE78_RS09755	COG1193	negative regulation of DNA recombination
DOE78_RS09810	COG1609	Transcriptional regulator
DOE78_RS09815	COG2267	carboxylic ester hydrolase activity
DOE78_RS09820	COG3706	GGDEF domain
DOE78_RS09825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DOE78_RS09840	COG4191	Histidine kinase
DOE78_RS09845	COG1683	Conserved Protein
DOE78_RS09850	COG1131	(ABC) transporter
DOE78_RS09855	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DOE78_RS09860	COG2963	transposase activity
DOE78_RS09865	COG2801	Transposase and inactivated derivatives
DOE78_RS09870	COG1525	nuclease
DOE78_RS09880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DOE78_RS09885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOE78_RS09905	COG3706	GGDEF domain
DOE78_RS09910	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DOE78_RS09920	COG2357	RelA SpoT domain protein
DOE78_RS09925	COG0194	GDP metabolic process
DOE78_RS09930	COG0492	ferredoxin-NADP+ reductase activity
DOE78_RS09935	COG2368	4-hydroxyphenylacetate
DOE78_RS09945	COG1695	Transcriptional regulator
DOE78_RS09960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DOE78_RS09965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE78_RS09975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE78_RS09985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DOE78_RS09990	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS10030	COG1846	Transcriptional regulator
DOE78_RS10035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DOE78_RS10040	COG0561	phosphatase activity
DOE78_RS10045	COG0183	Belongs to the thiolase family
DOE78_RS10050	COG5278	phosphoserine phosphatase activity
DOE78_RS10050	COG0840	transmembrane signaling receptor activity
DOE78_RS10055	COG5002	protein histidine kinase activity
DOE78_RS10065	COG0124	histidyl-tRNA synthetase
DOE78_RS10070	COG0456	acetyltransferase
DOE78_RS10075	COG2329	Antibiotic biosynthesis monooxygenase
DOE78_RS10085	COG1357	PFAM Pentapeptide repeats (8 copies)
DOE78_RS10100	COG3118	belongs to the thioredoxin family
DOE78_RS10105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DOE78_RS10110	COG1011	Hydrolase
DOE78_RS10125	COG1940	carbohydrate kinase activity
DOE78_RS10135	COG0346	lactoylglutathione lyase activity
DOE78_RS10150	COG0412	Dienelactone hydrolase
DOE78_RS10160	COG3829	transcription factor binding
DOE78_RS10165	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS10170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DOE78_RS10175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DOE78_RS10185	COG0833	amino acid
DOE78_RS10195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOE78_RS10200	COG5002	protein histidine kinase activity
DOE78_RS10215	COG0861	Integral membrane protein TerC family
DOE78_RS10245	COG0604	alcohol dehydrogenase
DOE78_RS10250	COG0730	response to heat
DOE78_RS10255	COG1959	2 iron, 2 sulfur cluster binding
DOE78_RS10260	COG5583	Uncharacterized small protein (DUF2292)
DOE78_RS10275	COG1116	anion transmembrane transporter activity
DOE78_RS10280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOE78_RS10305	COG2723	6-phospho-beta-galactosidase activity
DOE78_RS10315	COG1609	Transcriptional regulator
DOE78_RS10320	COG1263	PTS System
DOE78_RS10320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOE78_RS10325	COG1621	beta-fructofuranosidase activity
DOE78_RS10330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS10335	COG0024	Methionine aminopeptidase
DOE78_RS10340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOE78_RS10360	COG2112	serine threonine protein kinase
DOE78_RS10365	COG2252	PERMEase
DOE78_RS10375	COG0346	lactoylglutathione lyase activity
DOE78_RS10380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DOE78_RS10385	COG0346	lactoylglutathione lyase activity
DOE78_RS10390	COG0400	carboxylic ester hydrolase activity
DOE78_RS10425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DOE78_RS10440	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS10445	COG0506	proline dehydrogenase activity
DOE78_RS10450	COG1396	sequence-specific DNA binding
DOE78_RS10455	COG0252	asparaginase activity
DOE78_RS10460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOE78_RS10465	COG3773	Cell wall hydrolase
DOE78_RS10470	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS10480	COG2084	Dehydrogenase
DOE78_RS10485	COG3773	Cell wall hydrolase
DOE78_RS10490	COG3706	GGDEF domain
DOE78_RS10500	COG1279	arginine transmembrane transporter activity
DOE78_RS10510	COG3647	Membrane
DOE78_RS10520	COG3401	FG-GAP repeat protein
DOE78_RS10525	COG5001	Diguanylate cyclase
DOE78_RS10525	COG3300	MHYT domain
DOE78_RS10530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DOE78_RS10535	COG1742	UPF0060 membrane protein
DOE78_RS10540	COG2153	protein acetylation
DOE78_RS10550	COG0840	transmembrane signaling receptor activity
DOE78_RS10565	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS10570	COG1454	alcohol dehydrogenase
DOE78_RS10575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOE78_RS10580	COG0456	acetyltransferase
DOE78_RS10585	COG2814	Major facilitator Superfamily
DOE78_RS10595	COG1607	acyl-coa hydrolase
DOE78_RS10600	COG3401	FG-GAP repeat protein
DOE78_RS10615	COG0840	transmembrane signaling receptor activity
DOE78_RS10615	COG3290	protein histidine kinase activity
DOE78_RS10630	COG0346	lactoylglutathione lyase activity
DOE78_RS10635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOE78_RS10645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE78_RS10660	COG0805	protein transport
DOE78_RS10670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DOE78_RS10675	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DOE78_RS10680	COG2205	protein histidine kinase activity
DOE78_RS10685	COG2188	Transcriptional regulator
DOE78_RS10690	COG0765	amino acid transport
DOE78_RS10695	COG1126	abc transporter atp-binding protein
DOE78_RS10700	COG2222	sugar isomerase
DOE78_RS10705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOE78_RS10710	COG0583	DNA-binding transcription factor activity
DOE78_RS10715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DOE78_RS10720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS10730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DOE78_RS10740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOE78_RS10755	COG0436	Aminotransferase
DOE78_RS10780	COG0668	transmembrane transport
DOE78_RS10785	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS10810	COG5002	protein histidine kinase activity
DOE78_RS10815	COG2323	membrane
DOE78_RS10850	COG0840	transmembrane signaling receptor activity
DOE78_RS10875	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS10895	COG0840	transmembrane signaling receptor activity
DOE78_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS10915	COG4191	Histidine kinase
DOE78_RS10935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS10940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS10950	COG1447	Phosphotransferase system cellobiose-specific component IIA
DOE78_RS10955	COG1486	melibiose metabolic process
DOE78_RS10965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE78_RS10975	COG2382	esterase
DOE78_RS10975	COG3693	PFAM glycoside hydrolase, family 10
DOE78_RS10975	COG3507	Belongs to the glycosyl hydrolase 43 family
DOE78_RS10980	COG2207	Transcriptional regulator
DOE78_RS11005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOE78_RS11010	COG1595	DNA-templated transcription, initiation
DOE78_RS11040	COG3123	guanosine phosphorylase activity
DOE78_RS11050	COG1476	TRANSCRIPTIONal
DOE78_RS11075	COG5578	integral membrane protein
DOE78_RS11085	COG2972	Histidine kinase
DOE78_RS11090	COG2204	response regulator
DOE78_RS11120	COG0395	ABC-type sugar transport system, permease component
DOE78_RS11145	COG0454	-acetyltransferase
DOE78_RS11150	COG5002	protein histidine kinase activity
DOE78_RS11160	COG1136	(ABC) transporter
DOE78_RS11165	COG0577	efflux transmembrane transporter activity
DOE78_RS11180	COG0772	Belongs to the SEDS family
DOE78_RS11190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE78_RS11190	COG4499	WXG100 protein secretion system (Wss), protein YukC
DOE78_RS11225	COG1917	Cupin 2, conserved barrel domain protein
DOE78_RS11225	COG2207	Transcriptional regulator
DOE78_RS11230	COG2364	Membrane
DOE78_RS11235	COG2153	protein acetylation
DOE78_RS11240	COG1846	Transcriptional regulator
DOE78_RS11245	COG0456	acetyltransferase
DOE78_RS11250	COG2808	Putative FMN-binding domain
DOE78_RS11265	COG1268	BioY protein
DOE78_RS11315	COG3706	GGDEF domain
DOE78_RS11330	COG3011	Protein conserved in bacteria
DOE78_RS11355	COG1074	ATP-dependent DNA helicase activity
DOE78_RS11365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE78_RS11385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DOE78_RS11400	COG0604	alcohol dehydrogenase
DOE78_RS11425	COG1609	Transcriptional regulator
DOE78_RS11430	COG3655	Transcriptional regulator
DOE78_RS11470	COG1104	cysteine desulfurase activity
DOE78_RS11505	COG0433	COG0433 Predicted ATPase
DOE78_RS11540	COG0305	Participates in initiation and elongation during chromosome replication
DOE78_RS11550	COG1525	nuclease
DOE78_RS11575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DOE78_RS11630	COG0604	alcohol dehydrogenase
DOE78_RS11650	COG2169	Transcriptional regulator
DOE78_RS11655	COG2211	Major facilitator Superfamily
DOE78_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS11665	COG1063	alcohol dehydrogenase
DOE78_RS11670	COG3959	Transketolase, thiamine diphosphate binding domain
DOE78_RS11675	COG3958	Transketolase
DOE78_RS11685	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS11720	COG1063	alcohol dehydrogenase
DOE78_RS11725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DOE78_RS11730	COG1151	hydroxylamine reductase activity
DOE78_RS11740	COG0431	NADPH-dependent FMN reductase
DOE78_RS11745	COG0346	lactoylglutathione lyase activity
DOE78_RS11765	COG0003	Pfam Anion-transporting ATPase
DOE78_RS11785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DOE78_RS11815	COG0318	PFAM AMP-dependent synthetase and ligase
DOE78_RS11820	COG1024	Enoyl-CoA hydratase
DOE78_RS11825	COG0659	secondary active sulfate transmembrane transporter activity
DOE78_RS11855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE78_RS11870	COG1609	Transcriptional regulator
DOE78_RS11875	COG1653	transport
DOE78_RS11880	COG1175	transmembrane transport
DOE78_RS11885	COG0395	ABC-type sugar transport system, permease component
DOE78_RS11890	COG1486	melibiose metabolic process
DOE78_RS11900	COG2723	6-phospho-beta-galactosidase activity
DOE78_RS11920	COG0395	ABC-type sugar transport system, permease component
DOE78_RS11925	COG3842	ATPase activity
DOE78_RS11930	COG5001	Diguanylate cyclase
DOE78_RS11930	COG3300	MHYT domain
DOE78_RS11940	COG1653	transport
DOE78_RS11945	COG2972	Histidine kinase
DOE78_RS11950	COG4753	response regulator
DOE78_RS11950	COG2207	Transcriptional regulator
DOE78_RS11965	COG0395	ABC-type sugar transport system, permease component
DOE78_RS11970	COG1621	beta-fructofuranosidase activity
DOE78_RS11980	COG1253	flavin adenine dinucleotide binding
DOE78_RS11995	COG0523	cobalamin synthesis protein
DOE78_RS12000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DOE78_RS12025	COG0444	Belongs to the ABC transporter superfamily
DOE78_RS12030	COG4608	Belongs to the ABC transporter superfamily
DOE78_RS12035	COG1388	LysM domain
DOE78_RS12045	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOE78_RS12080	COG4989	oxidoreductase activity
DOE78_RS12090	COG1802	Transcriptional regulator
DOE78_RS12100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DOE78_RS12105	COG2011	ABC-type metal ion transport system permease component
DOE78_RS12120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DOE78_RS12135	COG2272	Belongs to the type-B carboxylesterase lipase family
DOE78_RS12150	COG1051	belongs to the nudix hydrolase family
DOE78_RS12155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DOE78_RS12170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DOE78_RS12195	COG0366	Alpha amylase catalytic
DOE78_RS12205	COG2972	Histidine kinase
DOE78_RS12210	COG3279	Response regulator of the LytR AlgR family
DOE78_RS12220	COG4209	transmembrane transport
DOE78_RS12225	COG0395	ABC-type sugar transport system, permease component
DOE78_RS12255	COG0583	DNA-binding transcription factor activity
DOE78_RS12260	COG0067	glutamate synthase
DOE78_RS12260	COG0069	glutamate synthase activity
DOE78_RS12260	COG0070	glutamate synthase
DOE78_RS12265	COG0493	'glutamate synthase
DOE78_RS12280	COG0673	inositol 2-dehydrogenase activity
DOE78_RS12290	COG0673	inositol 2-dehydrogenase activity
DOE78_RS12295	COG1879	ABC-type sugar transport system periplasmic component
DOE78_RS12300	COG1129	ABC transporter
DOE78_RS12305	COG1172	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS12310	COG1472	Belongs to the glycosyl hydrolase 3 family
DOE78_RS12370	COG2072	flavoprotein involved in K transport
DOE78_RS12385	COG0697	spore germination
DOE78_RS12395	COG1113	amino acid transport
DOE78_RS12410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DOE78_RS12430	COG3118	belongs to the thioredoxin family
DOE78_RS12475	COG2340	Cysteine-rich secretory protein family
DOE78_RS12485	COG1192	Involved in chromosome partitioning
DOE78_RS12495	COG2076	Multidrug Resistance protein
DOE78_RS12500	COG2076	Multidrug Resistance protein
DOE78_RS12505	COG1309	transcriptional regulator
DOE78_RS12510	COG0778	Nitroreductase
DOE78_RS12515	COG1846	Transcriptional regulator
DOE78_RS12525	COG4912	Dna alkylation repair
DOE78_RS12545	COG0768	penicillin binding
DOE78_RS12550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOE78_RS12560	COG1113	amino acid transport
DOE78_RS12580	COG2208	phosphoserine phosphatase activity
DOE78_RS12585	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS12590	COG2135	peptidase activity
DOE78_RS12595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOE78_RS12600	COG0582	viral genome integration into host DNA
DOE78_RS12605	COG3263	regulation of cellular component size
DOE78_RS12640	COG2329	Antibiotic biosynthesis monooxygenase
DOE78_RS12650	COG1335	isochorismatase
DOE78_RS12655	COG3403	YqcI/YcgG family
DOE78_RS12660	COG2217	Heavy metal translocating P-type atpase
DOE78_RS12670	COG0671	phosphoesterase, PA-phosphatase related
DOE78_RS12685	COG2259	Doxx family
DOE78_RS12690	COG0501	Belongs to the peptidase M48B family
DOE78_RS12700	COG2814	Major facilitator Superfamily
DOE78_RS12730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DOE78_RS12735	COG0805	protein transport
DOE78_RS12740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOE78_RS12740	COG3711	transcriptional antiterminator
DOE78_RS12780	COG2814	Major facilitator Superfamily
DOE78_RS12845	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DOE78_RS12860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DOE78_RS12870	COG0657	acetylesterase activity
DOE78_RS12875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOE78_RS12895	COG0740	serine-type endopeptidase activity
DOE78_RS12900	COG2076	Multidrug Resistance protein
DOE78_RS12905	COG2076	Multidrug Resistance protein
DOE78_RS12915	COG0720	synthase
DOE78_RS12930	COG0477	Major facilitator Superfamily
DOE78_RS12935	COG3507	Belongs to the glycosyl hydrolase 43 family
DOE78_RS12965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DOE78_RS12970	COG0840	transmembrane signaling receptor activity
DOE78_RS12975	COG4213	ABC transporter substrate-binding protein
DOE78_RS12980	COG0534	Mate efflux family protein
DOE78_RS12985	COG0840	transmembrane signaling receptor activity
DOE78_RS12995	COG0352	thiamine-phosphate diphosphorylase activity
DOE78_RS13000	COG0351	phosphomethylpyrimidine kinase
DOE78_RS13005	COG2022	thiamine diphosphate biosynthetic process
DOE78_RS13025	COG1116	anion transmembrane transporter activity
DOE78_RS13030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOE78_RS13035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DOE78_RS13045	COG0352	thiamine-phosphate diphosphorylase activity
DOE78_RS13050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DOE78_RS13060	COG3858	chitin binding
DOE78_RS13065	COG1247	-acetyltransferase
DOE78_RS13100	COG0456	acetyltransferase
DOE78_RS13100	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DOE78_RS13105	COG0745	RESPONSE REGULATOR receiver
DOE78_RS13110	COG5002	protein histidine kinase activity
DOE78_RS13110	COG3850	Histidine kinase
DOE78_RS13125	COG0673	inositol 2-dehydrogenase activity
DOE78_RS13140	COG0561	phosphatase activity
DOE78_RS13145	COG1309	transcriptional regulator
DOE78_RS13150	COG1309	transcriptional regulator
DOE78_RS13155	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DOE78_RS13170	COG1842	Phage shock protein A
DOE78_RS13180	COG1164	Oligoendopeptidase f
DOE78_RS13215	COG0419	ATPase involved in DNA repair
DOE78_RS13225	COG1366	Belongs to the anti-sigma-factor antagonist family
DOE78_RS13240	COG0167	dihydroorotate dehydrogenase activity
DOE78_RS13260	COG2508	Transcriptional regulator
DOE78_RS13265	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS13270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DOE78_RS13290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DOE78_RS13295	COG2146	nitrite reductase [NAD(P)H] activity
DOE78_RS13300	COG1587	Uroporphyrinogen-III synthase
DOE78_RS13300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DOE78_RS13310	COG1368	sulfuric ester hydrolase activity
DOE78_RS13325	COG0791	NLP P60 protein
DOE78_RS13325	COG1388	LysM domain
DOE78_RS13330	COG1363	Peptidase, m42
DOE78_RS13335	COG4191	Histidine kinase
DOE78_RS13340	COG2364	Membrane
DOE78_RS13350	COG0673	inositol 2-dehydrogenase activity
DOE78_RS13360	COG3973	AAA domain
DOE78_RS13365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOE78_RS13375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DOE78_RS13380	COG1970	mechanosensitive ion channel activity
DOE78_RS13405	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DOE78_RS13410	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DOE78_RS13420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE78_RS13460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DOE78_RS13465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DOE78_RS13475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOE78_RS13495	COG0464	growth
DOE78_RS13500	COG0824	Thioesterase
DOE78_RS13510	COG4841	protein insertion into membrane
DOE78_RS13520	COG2843	Capsule synthesis protein
DOE78_RS13525	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DOE78_RS13525	COG0392	lysyltransferase activity
DOE78_RS13530	COG4191	Histidine kinase
DOE78_RS13540	COG3858	chitin binding
DOE78_RS13545	COG1832	CoA-binding protein
DOE78_RS13550	COG0187	DNA topoisomerase II activity
DOE78_RS13555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DOE78_RS13565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE78_RS13595	COG1940	carbohydrate kinase activity
DOE78_RS13600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOE78_RS13620	COG2972	Histidine kinase
DOE78_RS13625	COG2207	Transcriptional regulator
DOE78_RS13625	COG0662	Cupin 2, conserved barrel domain protein
DOE78_RS13675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOE78_RS13675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOE78_RS13690	COG0702	epimerase
DOE78_RS13710	COG1621	beta-fructofuranosidase activity
DOE78_RS13755	COG2318	DinB family
DOE78_RS13810	COG2124	cytochrome p450
DOE78_RS13820	COG0156	8-amino-7-oxononanoate synthase activity
DOE78_RS13825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DOE78_RS13830	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
DOE78_RS13865	COG4753	response regulator
DOE78_RS13865	COG2207	Transcriptional regulator
DOE78_RS13870	COG2972	Histidine kinase
DOE78_RS13885	COG1175	transmembrane transport
DOE78_RS13890	COG5522	Integral membrane protein (intg_mem_TP0381)
DOE78_RS13910	COG0561	phosphatase activity
DOE78_RS13920	COG3773	Cell wall hydrolase
DOE78_RS13925	COG5002	protein histidine kinase activity
DOE78_RS13930	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DOE78_RS13940	COG3250	beta-galactosidase activity
DOE78_RS13960	COG2972	Histidine kinase
DOE78_RS13965	COG2207	Transcriptional regulator
DOE78_RS13965	COG4753	response regulator
DOE78_RS13980	COG1876	peptidase activity
DOE78_RS13990	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DOE78_RS13995	COG0778	Nitroreductase
DOE78_RS14010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DOE78_RS14015	COG1132	(ABC) transporter
DOE78_RS14025	COG1846	Transcriptional regulator
DOE78_RS14035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOE78_RS14045	COG2188	Transcriptional regulator
DOE78_RS14050	COG2723	6-phospho-beta-galactosidase activity
DOE78_RS14055	COG0473	3-isopropylmalate dehydrogenase activity
DOE78_RS14065	COG3958	Transketolase
DOE78_RS14070	COG3959	Transketolase, thiamine diphosphate binding domain
DOE78_RS14075	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DOE78_RS14075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DOE78_RS14085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DOE78_RS14090	COG1063	alcohol dehydrogenase
DOE78_RS14095	COG1063	alcohol dehydrogenase
DOE78_RS14100	COG1609	Transcriptional regulator
DOE78_RS14110	COG0531	amino acid
DOE78_RS14115	COG1309	transcriptional regulator
DOE78_RS14120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DOE78_RS14120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DOE78_RS14125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DOE78_RS14125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DOE78_RS14135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DOE78_RS14140	COG0488	(ABC) transporter
DOE78_RS14155	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS14160	COG0028	Belongs to the TPP enzyme family
DOE78_RS14175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DOE78_RS14190	COG1609	Transcriptional regulator
DOE78_RS14195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DOE78_RS14195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DOE78_RS14200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DOE78_RS14200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DOE78_RS14205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DOE78_RS14250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DOE78_RS14255	COG2323	membrane
DOE78_RS14260	COG0010	Belongs to the arginase family
DOE78_RS14265	COG1228	amidohydrolase
DOE78_RS14270	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DOE78_RS14275	COG2986	histidine ammonia-lyase
DOE78_RS14280	COG3546	catalase activity
DOE78_RS14295	COG1657	PFAM Prenyltransferase squalene oxidase
DOE78_RS14300	COG1388	LysM domain
DOE78_RS14300	COG0791	NLP P60 protein
DOE78_RS14315	COG2197	response regulator
DOE78_RS14320	COG4585	Histidine kinase
DOE78_RS14330	COG0693	protein deglycase activity
DOE78_RS14335	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DOE78_RS14350	COG0708	Exodeoxyribonuclease III
DOE78_RS14360	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DOE78_RS14370	COG2027	D-alanyl-D-alanine carboxypeptidase
DOE78_RS14375	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS14380	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DOE78_RS14395	COG0789	Transcriptional regulator
DOE78_RS14400	COG1392	Phosphate transport regulator
DOE78_RS14405	COG0306	phosphate transporter
DOE78_RS14415	COG0346	lactoylglutathione lyase activity
DOE78_RS14425	COG0463	Glycosyl transferase, family 2
DOE78_RS14435	COG2340	Cysteine-rich secretory protein family
DOE78_RS14455	COG5002	protein histidine kinase activity
DOE78_RS14465	COG1164	Oligoendopeptidase f
DOE78_RS14490	COG2116	formate transmembrane transporter activity
DOE78_RS14495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOE78_RS14500	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS14515	COG0488	(ABC) transporter
DOE78_RS14525	COG0725	ABC transporter, periplasmic molybdate-binding protein
DOE78_RS14530	COG4149	molybdate abc transporter
DOE78_RS14535	COG1686	Belongs to the peptidase S11 family
DOE78_RS14550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DOE78_RS14560	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DOE78_RS14570	COG0706	membrane insertase activity
DOE78_RS14580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DOE78_RS14595	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DOE78_RS14595	COG2105	PFAM AIG2 family protein
DOE78_RS14610	COG0626	cystathionine gamma-synthase activity
DOE78_RS14615	COG0626	cystathionine gamma-synthase activity
DOE78_RS14620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DOE78_RS14620	COG0646	methionine synthase
DOE78_RS14625	COG0646	methionine synthase
DOE78_RS14625	COG1410	methionine synthase
DOE78_RS14630	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DOE78_RS14635	COG1984	allophanate hydrolase subunit 2
DOE78_RS14640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DOE78_RS14655	COG0598	Magnesium transport protein CorA
DOE78_RS14670	COG4585	Histidine kinase
DOE78_RS14680	COG2197	response regulator
DOE78_RS14690	COG2223	nitrite transmembrane transporter activity
DOE78_RS14720	COG0243	molybdopterin cofactor binding
DOE78_RS14730	COG1418	mRNA catabolic process
DOE78_RS14750	COG1253	flavin adenine dinucleotide binding
DOE78_RS14755	COG1115	amino acid carrier protein
DOE78_RS14760	COG2720	vancomycin resistance protein
DOE78_RS14765	COG2861	carbohydrate metabolic process
DOE78_RS14770	COG3859	Proton-coupled thiamine transporter YuaJ
DOE78_RS14775	COG5278	phosphoserine phosphatase activity
DOE78_RS14775	COG0840	transmembrane signaling receptor activity
DOE78_RS14780	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DOE78_RS14785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DOE78_RS14790	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DOE78_RS14795	COG1131	(ABC) transporter
DOE78_RS14800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DOE78_RS14805	COG4536	flavin adenine dinucleotide binding
DOE78_RS14810	COG0527	aspartate kinase activity
DOE78_RS14820	COG1595	DNA-templated transcription, initiation
DOE78_RS14830	COG1131	(ABC) transporter
DOE78_RS14835	COG1725	Transcriptional regulator
DOE78_RS14855	COG2318	DinB family
DOE78_RS14875	COG3852	Histidine kinase
DOE78_RS14880	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DOE78_RS14885	COG1131	(ABC) transporter
DOE78_RS14890	COG2755	lipolytic protein G-D-S-L family
DOE78_RS14905	COG1115	amino acid carrier protein
DOE78_RS14910	COG0398	Pfam SNARE associated Golgi protein
DOE78_RS14915	COG0788	formyltetrahydrofolate deformylase activity
DOE78_RS14925	COG0322	excinuclease ABC activity
DOE78_RS14930	COG1183	phosphatidylcholine synthase activity
DOE78_RS14940	COG4191	Histidine kinase
DOE78_RS14950	COG2116	formate transmembrane transporter activity
DOE78_RS14955	COG2323	membrane
DOE78_RS14965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DOE78_RS14970	COG1845	cytochrome c oxidase, subunit III
DOE78_RS14975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DOE78_RS14985	COG1280	lysine exporter protein (LysE YggA)
DOE78_RS15000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DOE78_RS15000	COG3153	acetyltransferase
DOE78_RS15010	COG1132	(ABC) transporter
DOE78_RS15025	COG0628	permease
DOE78_RS15035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOE78_RS15055	COG0134	indole-3-glycerol-phosphate synthase activity
DOE78_RS15065	COG0512	Glutamine amidotransferase of anthranilate synthase
DOE78_RS15080	COG2258	MOSC domain
DOE78_RS15085	COG2814	Major facilitator Superfamily
DOE78_RS15090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOE78_RS15090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOE78_RS15090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOE78_RS15095	COG1105	Belongs to the carbohydrate kinase PfkB family
DOE78_RS15100	COG1349	DNA-binding transcription factor activity
DOE78_RS15135	COG1280	lysine exporter protein (LysE YggA)
DOE78_RS15140	COG1113	amino acid transport
DOE78_RS15145	COG3852	Histidine kinase
DOE78_RS15165	COG0513	Belongs to the DEAD box helicase family
DOE78_RS15175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DOE78_RS15180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DOE78_RS15190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DOE78_RS15195	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DOE78_RS15200	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DOE78_RS15205	COG3285	dna ligase
DOE78_RS15205	COG1793	dna ligase
DOE78_RS15215	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DOE78_RS15225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOE78_RS15240	COG4667	esterase of the alpha-beta hydrolase superfamily
DOE78_RS15255	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DOE78_RS15265	COG0534	Mate efflux family protein
DOE78_RS15275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DOE78_RS15280	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS15300	COG5002	protein histidine kinase activity
DOE78_RS15300	COG3850	Histidine kinase
DOE78_RS15305	COG0745	RESPONSE REGULATOR receiver
DOE78_RS15315	COG1272	protein, Hemolysin III
DOE78_RS15330	COG0523	cobalamin synthesis protein
DOE78_RS15340	COG0793	Belongs to the peptidase S41A family
DOE78_RS15340	COG3409	Peptidoglycan-binding domain 1 protein
DOE78_RS15345	COG1876	peptidase activity
DOE78_RS15360	COG4326	sporulation control protein
DOE78_RS15385	COG4479	Belongs to the UPF0346 family
DOE78_RS15400	COG3279	Response regulator of the LytR AlgR family
DOE78_RS15415	COG1509	lysine 2,3-aminomutase activity
DOE78_RS15420	COG3829	transcription factor binding
DOE78_RS15425	COG0456	acetyltransferase
DOE78_RS15430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOE78_RS15435	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DOE78_RS15440	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DOE78_RS15445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DOE78_RS15450	COG1619	proteins homologs of microcin C7 resistance protein MccF
DOE78_RS15470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOE78_RS15475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOE78_RS15495	COG2755	lipolytic protein G-D-S-L family
DOE78_RS15500	COG1999	signal sequence binding
DOE78_RS15505	COG5002	protein histidine kinase activity
DOE78_RS15525	COG0805	protein transport
DOE78_RS15530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DOE78_RS15535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DOE78_RS15545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DOE78_RS15550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DOE78_RS15565	COG2521	methyltransferase
DOE78_RS15565	COG2136	Putative SAM-dependent methyltransferase
DOE78_RS15575	COG1413	lyase activity
DOE78_RS15580	COG0488	(ABC) transporter
DOE78_RS15585	COG1418	mRNA catabolic process
DOE78_RS15595	COG0386	Belongs to the glutathione peroxidase family
DOE78_RS15615	COG1321	iron dependent repressor
DOE78_RS15625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DOE78_RS15630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DOE78_RS15635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOE78_RS15640	COG2508	Transcriptional regulator
DOE78_RS15650	COG2072	flavoprotein involved in K transport
DOE78_RS15655	COG2351	hydroxyisourate hydrolase activity
DOE78_RS15670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOE78_RS15680	COG2059	Chromate
DOE78_RS15685	COG2059	Chromate
DOE78_RS15690	COG0405	Gamma-glutamyltransferase
DOE78_RS15695	COG0154	amidase activity
DOE78_RS15710	COG1278	Cold shock
DOE78_RS15720	COG0328	RNA-DNA hybrid ribonuclease activity
DOE78_RS15725	COG0328	RNA-DNA hybrid ribonuclease activity
DOE78_RS15750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOE78_RS15760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DOE78_RS15765	COG1755	Isoprenylcysteine carboxyl methyltransferase
DOE78_RS15770	COG3424	synthase
DOE78_RS15795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DOE78_RS15800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DOE78_RS15805	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DOE78_RS15810	COG1199	ATP-dependent helicase activity
DOE78_RS15815	COG0116	Belongs to the methyltransferase superfamily
DOE78_RS15830	COG4474	Belongs to the UPF0398 family
DOE78_RS15840	COG3359	exonuclease
DOE78_RS15845	COG1111	helicase
DOE78_RS15845	COG1205	dead DEAH box helicase
DOE78_RS15850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOE78_RS15885	COG3331	DNA recombination
DOE78_RS15890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE78_RS15890	COG4499	WXG100 protein secretion system (Wss), protein YukC
DOE78_RS15900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DOE78_RS15905	COG3935	DnaD domain protein
DOE78_RS15910	COG0017	Asparaginyl-tRNA synthetase
DOE78_RS15915	COG0436	Aminotransferase
DOE78_RS15935	COG1199	ATP-dependent helicase activity
DOE78_RS15935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DOE78_RS15940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DOE78_RS15945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DOE78_RS15960	COG0617	tRNA 3'-terminal CCA addition
DOE78_RS15965	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS15970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DOE78_RS15975	COG1803	Methylglyoxal synthase
DOE78_RS15980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DOE78_RS15985	COG1694	Mazg nucleotide pyrophosphohydrolase
DOE78_RS15990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOE78_RS15995	COG2738	Putative neutral zinc metallopeptidase
DOE78_RS16005	COG4347	Protein of unknown function (DUF1405)
DOE78_RS16015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DOE78_RS16035	COG0457	Tetratricopeptide repeat
DOE78_RS16045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DOE78_RS16050	COG0287	Prephenate dehydrogenase
DOE78_RS16055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DOE78_RS16060	COG4401	Chorismate mutase type I
DOE78_RS16065	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DOE78_RS16070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DOE78_RS16075	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DOE78_RS16080	COG0105	UTP biosynthetic process
DOE78_RS16085	COG0142	geranyltranstransferase activity
DOE78_RS16090	COG2226	methyltransferase
DOE78_RS16095	COG0142	geranyltranstransferase activity
DOE78_RS16105	COG0302	gtp cyclohydrolase
DOE78_RS16110	COG0776	regulation of translation
DOE78_RS16115	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DOE78_RS16135	COG1160	GTP binding
DOE78_RS16160	COG1304	FMN binding
DOE78_RS16165	COG0539	negative regulation of cytoplasmic translation
DOE78_RS16170	COG0204	Acyl-transferase
DOE78_RS16175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DOE78_RS16190	COG2959	enzyme of heme biosynthesis
DOE78_RS16195	COG3773	Cell wall hydrolase
DOE78_RS16195	COG3409	Peptidoglycan-binding domain 1 protein
DOE78_RS16200	COG2339	peptidase activity
DOE78_RS16210	COG0492	ferredoxin-NADP+ reductase activity
DOE78_RS16215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DOE78_RS16220	COG4862	establishment of competence for transformation
DOE78_RS16230	COG1408	metallophosphoesterase
DOE78_RS16255	COG1266	CAAX protease self-immunity
DOE78_RS16260	COG0514	ATP-dependent DNA helicase (RecQ)
DOE78_RS16275	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DOE78_RS16280	COG1227	inorganic diphosphatase activity
DOE78_RS16285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DOE78_RS16290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DOE78_RS16295	COG0739	heme binding
DOE78_RS16295	COG0741	lytic transglycosylase activity
DOE78_RS16295	COG1196	nuclear chromosome segregation
DOE78_RS16305	COG1595	DNA-templated transcription, initiation
DOE78_RS16315	COG0745	RESPONSE REGULATOR receiver
DOE78_RS16320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DOE78_RS16325	COG1333	cytochrome c biogenesis protein
DOE78_RS16330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOE78_RS16335	COG1187	pseudouridine synthase activity
DOE78_RS16340	COG0700	Nucleoside recognition
DOE78_RS16345	COG2715	membrane protein required for spore maturation
DOE78_RS16350	COG1686	Belongs to the peptidase S11 family
DOE78_RS16355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DOE78_RS16370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DOE78_RS16380	COG1547	Domain of unknown function (DUF309)
DOE78_RS16395	COG0697	spore germination
DOE78_RS16420	COG2172	sigma factor antagonist activity
DOE78_RS16430	COG1686	Belongs to the peptidase S11 family
DOE78_RS16450	COG4974	Belongs to the 'phage' integrase family
DOE78_RS16460	COG0735	belongs to the Fur family
DOE78_RS16465	COG1300	Membrane
DOE78_RS16475	COG1379	DNA repair
DOE78_RS16490	COG0667	Aldo Keto reductase
DOE78_RS16505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DOE78_RS16510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DOE78_RS16515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOE78_RS16520	COG0697	spore germination
DOE78_RS16545	COG1073	alpha beta
DOE78_RS16555	COG4918	Iron-sulphur cluster biosynthesis
DOE78_RS16570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DOE78_RS16580	COG0300	oxidoreductase activity
DOE78_RS16585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOE78_RS16590	COG0697	spore germination
DOE78_RS16595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOE78_RS16600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DOE78_RS16615	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DOE78_RS16635	COG0298	carbon dioxide binding
DOE78_RS16640	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DOE78_RS16645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DOE78_RS16650	COG0375	protein maturation
DOE78_RS16665	COG1234	tRNA 3'-trailer cleavage
DOE78_RS16680	COG1131	(ABC) transporter
DOE78_RS16685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DOE78_RS16690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DOE78_RS16695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DOE78_RS16700	COG0835	chemotaxis
DOE78_RS16705	COG2195	Cleaves the N-terminal amino acid of tripeptides
DOE78_RS16710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DOE78_RS16715	COG0346	lactoylglutathione lyase activity
DOE78_RS16720	COG1376	ErfK ybiS ycfS ynhG family protein
DOE78_RS16725	COG4129	membrane
DOE78_RS16735	COG1703	isobutyryl-CoA mutase activity
DOE78_RS16740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DOE78_RS16740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DOE78_RS16745	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DOE78_RS16750	COG0508	dehydrogenase complex catalyzes the overall conversion of
DOE78_RS16755	COG0022	dehydrogenase e1 component
DOE78_RS16760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DOE78_RS16765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DOE78_RS16770	COG3426	butyrate kinase activity
DOE78_RS16780	COG0280	phosphate acetyltransferase
DOE78_RS16785	COG3829	transcription factor binding
DOE78_RS16785	COG3290	protein histidine kinase activity
DOE78_RS16795	COG0584	glycerophosphoryl diester phosphodiesterase
DOE78_RS16815	COG0745	RESPONSE REGULATOR receiver
DOE78_RS16820	COG0750	zinc metalloprotease
DOE78_RS16825	COG0497	DNA recombination
DOE78_RS16830	COG1438	arginine binding
DOE78_RS16835	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DOE78_RS16840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DOE78_RS16850	COG1722	exodeoxyribonuclease VII activity
DOE78_RS16860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DOE78_RS16865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOE78_RS16870	COG1302	Protein conserved in bacteria
DOE78_RS16875	COG0439	Biotin carboxylase
DOE78_RS16880	COG0511	ligase activity, forming carbon-carbon bonds
DOE78_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS16890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DOE78_RS16900	COG4585	Histidine kinase
DOE78_RS16900	COG2203	Gaf domain
DOE78_RS16905	COG2197	response regulator
DOE78_RS16945	COG3854	ATPases associated with a variety of cellular activities
DOE78_RS16955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DOE78_RS16960	COG0006	proline dipeptidase activity
DOE78_RS16980	COG1752	Esterase of the alpha-beta hydrolase superfamily
DOE78_RS16990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOE78_RS17000	COG0095	Lipoate-protein ligase
DOE78_RS17005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DOE78_RS17010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DOE78_RS17015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DOE78_RS17020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DOE78_RS17025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DOE78_RS17060	COG4537	Required for transformation and DNA binding
DOE78_RS17065	COG1459	type II secretion system
DOE78_RS17070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DOE78_RS17080	COG1393	Belongs to the ArsC family
DOE78_RS17100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DOE78_RS17120	COG1368	sulfuric ester hydrolase activity
DOE78_RS17125	COG1940	carbohydrate kinase activity
DOE78_RS17135	COG0697	spore germination
DOE78_RS17140	COG0457	Tetratricopeptide repeat
DOE78_RS17140	COG0705	Rhomboid family
DOE78_RS17160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DOE78_RS17165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DOE78_RS17175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DOE78_RS17195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DOE78_RS17200	COG0704	Plays a role in the regulation of phosphate uptake
DOE78_RS17205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DOE78_RS17210	COG0581	inorganic phosphate transmembrane transporter activity
DOE78_RS17215	COG0573	inorganic phosphate transmembrane transporter activity
DOE78_RS17220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DOE78_RS17225	COG0768	penicillin binding
DOE78_RS17230	COG0477	Major facilitator Superfamily
DOE78_RS17240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOE78_RS17245	COG2839	Protein conserved in bacteria
DOE78_RS17250	COG1283	sodium-dependent phosphate transmembrane transporter activity
DOE78_RS17255	COG5521	maltodextrose utilization protein MalA
DOE78_RS17260	COG1388	LysM domain
DOE78_RS17270	COG4709	membrane
DOE78_RS17275	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DOE78_RS17280	COG0735	belongs to the Fur family
DOE78_RS17285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DOE78_RS17290	COG1121	(ABC) transporter
DOE78_RS17300	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DOE78_RS17305	COG0513	Belongs to the DEAD box helicase family
DOE78_RS17315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DOE78_RS17320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DOE78_RS17325	COG2384	SAM-dependent methyltransferase
DOE78_RS17330	COG2010	Cytochrome c
DOE78_RS17335	COG1960	acyl-CoA dehydrogenase activity
DOE78_RS17345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DOE78_RS17355	COG1671	Belongs to the UPF0178 family
DOE78_RS17360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DOE78_RS17365	COG0517	IMP dehydrogenase activity
DOE78_RS17370	COG0751	glycine-tRNA ligase activity
DOE78_RS17380	COG1381	Involved in DNA repair and RecF pathway recombination
DOE78_RS17390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DOE78_RS17400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DOE78_RS17405	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DOE78_RS17410	COG1480	7TM receptor with intracellular HD hydrolase
DOE78_RS17415	COG1702	phosphate starvation-inducible protein PhoH
DOE78_RS17435	COG4864	UPF0365 protein
DOE78_RS17440	COG1030	water channel activity
DOE78_RS17445	COG1610	YqeY-like protein
DOE78_RS17455	COG1283	sodium-dependent phosphate transmembrane transporter activity
DOE78_RS17460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DOE78_RS17465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DOE78_RS17470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DOE78_RS17475	COG2264	protein methyltransferase activity
DOE78_RS17490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DOE78_RS17495	COG1420	regulation of RNA biosynthetic process
DOE78_RS17500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DOE78_RS17505	COG0481	GTPase activity
DOE78_RS17515	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOE78_RS17525	COG0268	Binds directly to 16S ribosomal RNA
DOE78_RS17530	COG1466	dna polymerase III delta subunit
DOE78_RS17540	COG2333	competence protein COMEC
DOE78_RS17540	COG0658	competence protein
DOE78_RS17545	COG2131	deaminase
DOE78_RS17550	COG1596	polysaccharide export
DOE78_RS17550	COG1555	photosystem II stabilization
DOE78_RS17555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DOE78_RS17560	COG2226	methyltransferase
DOE78_RS17565	COG0799	negative regulation of ribosome biogenesis
DOE78_RS17570	COG1713	HD superfamily hydrolase involved in NAD metabolism
DOE78_RS17575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DOE78_RS17580	COG1534	Rna-binding protein
DOE78_RS17590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DOE78_RS17595	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DOE78_RS17605	COG0688	phosphatidylethanolamine metabolic process
DOE78_RS17610	COG1183	phosphatidylcholine synthase activity
DOE78_RS17645	COG0768	penicillin binding
DOE78_RS17650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DOE78_RS17655	COG0572	uridine kinase
DOE78_RS17660	COG0826	peptidase U32
DOE78_RS17665	COG0826	peptidase U32
DOE78_RS17670	COG4122	O-methyltransferase activity
DOE78_RS17675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DOE78_RS17680	COG3906	Belongs to the UPF0473 family
DOE78_RS17685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DOE78_RS17690	COG4472	Bacterial protein of unknown function (DUF965)
DOE78_RS17695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DOE78_RS17700	COG0628	permease
DOE78_RS17720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DOE78_RS17725	COG0457	Tetratricopeptide repeat
DOE78_RS17735	COG1104	cysteine desulfurase activity
DOE78_RS17740	COG1959	2 iron, 2 sulfur cluster binding
DOE78_RS17745	COG2364	Membrane
DOE78_RS17750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DOE78_RS17755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DOE78_RS17765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DOE78_RS17770	COG0124	histidyl-tRNA synthetase
DOE78_RS17775	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOE78_RS17775	COG3103	Sh3 type 3 domain protein
DOE78_RS17775	COG4991	sh3 domain protein
DOE78_RS17785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DOE78_RS17790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DOE78_RS17795	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DOE78_RS17795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DOE78_RS17800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DOE78_RS17805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DOE78_RS17805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DOE78_RS17815	COG2244	polysaccharide biosynthetic process
DOE78_RS17830	COG1862	Preprotein translocase
DOE78_RS17840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DOE78_RS17875	COG1388	LysM domain
DOE78_RS17880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DOE78_RS17885	COG0157	Belongs to the NadC ModD family
DOE78_RS17890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DOE78_RS17895	COG1104	cysteine desulfurase activity
DOE78_RS17900	COG1827	regulation of RNA biosynthetic process
DOE78_RS17905	COG0077	Prephenate dehydratase
DOE78_RS17910	COG4492	Belongs to the UPF0735 family
DOE78_RS17915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DOE78_RS17920	COG3290	protein histidine kinase activity
DOE78_RS17930	COG2868	ribosomal protein
DOE78_RS17935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DOE78_RS17945	COG1994	Peptidase M50
DOE78_RS17950	COG0739	heme binding
DOE78_RS17955	COG2894	cell division
DOE78_RS17965	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DOE78_RS17970	COG1792	Involved in formation and maintenance of cell shape
DOE78_RS17975	COG1077	Cell shape determining protein MreB Mrl
DOE78_RS17980	COG2003	Belongs to the UPF0758 family
DOE78_RS17990	COG2003	Belongs to the UPF0758 family
DOE78_RS18010	COG0285	dihydrofolate synthase activity
DOE78_RS18015	COG0525	valine-tRNA ligase activity
DOE78_RS18025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DOE78_RS18030	COG1388	LysM domain
DOE78_RS18035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DOE78_RS18040	COG0113	porphobilinogen synthase activity
DOE78_RS18055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DOE78_RS18070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DOE78_RS18075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DOE78_RS18080	COG1067	ATP-dependent peptidase activity
DOE78_RS18080	COG0470	DNA polymerase III
DOE78_RS18085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DOE78_RS18090	COG0544	peptidyl-prolyl cis-trans isomerase activity
DOE78_RS18095	COG1477	protein flavinylation
DOE78_RS18095	COG0457	Tetratricopeptide repeat
DOE78_RS18100	COG0066	3-isopropylmalate dehydratase activity
DOE78_RS18105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DOE78_RS18115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DOE78_RS18120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DOE78_RS18125	COG0440	acetolactate synthase activity
DOE78_RS18130	COG0028	Belongs to the TPP enzyme family
DOE78_RS18135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DOE78_RS18140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOE78_RS18145	COG0601	transmembrane transport
DOE78_RS18150	COG0747	negative chemotaxis
DOE78_RS18155	COG4608	Belongs to the ABC transporter superfamily
DOE78_RS18160	COG0444	Belongs to the ABC transporter superfamily
DOE78_RS18170	COG0622	Phosphoesterase
DOE78_RS18175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DOE78_RS18180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DOE78_RS18185	COG5401	PFAM Sporulation and spore germination
DOE78_RS18195	COG1846	Transcriptional regulator
DOE78_RS18200	COG2197	response regulator
DOE78_RS18205	COG0824	Thioesterase
DOE78_RS18210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DOE78_RS18215	COG1053	succinate dehydrogenase
DOE78_RS18220	COG2009	succinate dehydrogenase
DOE78_RS18225	COG1719	4-vinyl reductase, 4VR
DOE78_RS18235	COG0322	excinuclease ABC activity
DOE78_RS18240	COG3118	belongs to the thioredoxin family
DOE78_RS18245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DOE78_RS18250	COG2086	electron transfer activity
DOE78_RS18255	COG1024	Enoyl-CoA hydratase
DOE78_RS18260	COG1309	transcriptional regulator
DOE78_RS18265	COG0318	PFAM AMP-dependent synthetase and ligase
DOE78_RS18270	COG3766	membrane
DOE78_RS18280	COG1796	DNA polymerase
DOE78_RS18280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DOE78_RS18285	COG1286	toxin biosynthetic process
DOE78_RS18290	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DOE78_RS18295	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DOE78_RS18300	COG0072	phenylalanine-tRNA ligase activity
DOE78_RS18300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOE78_RS18305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DOE78_RS18310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOE78_RS18320	COG1363	Peptidase, m42
DOE78_RS18335	COG0398	Pfam SNARE associated Golgi protein
DOE78_RS18340	COG3326	Membrane
DOE78_RS18345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DOE78_RS18350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DOE78_RS18355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DOE78_RS18360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DOE78_RS18370	COG1484	DNA-dependent DNA replication
DOE78_RS18380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DOE78_RS18390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DOE78_RS18395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DOE78_RS18405	COG1971	Probably functions as a manganese efflux pump
DOE78_RS18410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DOE78_RS18415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOE78_RS18415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOE78_RS18420	COG0330	HflC and HflK could
DOE78_RS18430	COG5002	protein histidine kinase activity
DOE78_RS18435	COG0745	RESPONSE REGULATOR receiver
DOE78_RS18445	COG0039	L-malate dehydrogenase activity
DOE78_RS18450	COG0538	isocitrate dehydrogenase activity
DOE78_RS18455	COG0372	Belongs to the citrate synthase family
DOE78_RS18460	COG2707	UPF0756 membrane protein
DOE78_RS18465	COG0628	permease
DOE78_RS18470	COG3030	protein affecting phage T7 exclusion by the F plasmid
DOE78_RS18480	COG0205	6-phosphofructokinase activity
DOE78_RS18485	COG0825	malonyl-CoA metabolic process
DOE78_RS18495	COG1725	Transcriptional regulator
DOE78_RS18500	COG0281	malic enzyme
DOE78_RS18505	COG0587	DNA-directed DNA polymerase activity
DOE78_RS18520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DOE78_RS18530	COG4109	DRTGG domain
DOE78_RS18540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DOE78_RS18545	COG0006	proline dipeptidase activity
DOE78_RS18555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE78_RS18560	COG0589	response to stress
DOE78_RS18565	COG0165	Argininosuccinate lyase
DOE78_RS18570	COG0137	argininosuccinate synthase activity
DOE78_RS18580	COG0737	Belongs to the 5'-nucleotidase family
DOE78_RS18585	COG0521	Mo-molybdopterin cofactor biosynthetic process
DOE78_RS18595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DOE78_RS18600	COG0827	DNA restriction-modification system
DOE78_RS18605	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DOE78_RS18610	COG3874	Sporulation protein YtfJ
DOE78_RS18620	COG1714	RDD family
DOE78_RS18625	COG0616	signal peptide processing
DOE78_RS18630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DOE78_RS18640	COG2962	Rard protein
DOE78_RS18645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DOE78_RS18655	COG0301	tRNA thio-modification
DOE78_RS18660	COG1104	cysteine desulfurase activity
DOE78_RS18665	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DOE78_RS18670	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DOE78_RS18675	COG1309	transcriptional regulator
DOE78_RS18680	COG1956	GAF domain-containing protein
DOE78_RS18685	COG0626	cystathionine gamma-synthase activity
DOE78_RS18690	COG2199	diguanylate cyclase activity
DOE78_RS18690	COG2203	Gaf domain
DOE78_RS18700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DOE78_RS18730	COG0739	heme binding
DOE78_RS18960	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DOE78_RS18965	COG0756	dUTP diphosphatase activity
DOE78_RS18990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DOE78_RS19000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOE78_RS19030	COG3118	belongs to the thioredoxin family
DOE78_RS19040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOE78_RS19040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOE78_RS19150	COG1585	Membrane protein implicated in regulation of membrane protease activity
DOE78_RS19170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DOE78_RS19175	COG0454	-acetyltransferase
DOE78_RS19180	COG0517	IMP dehydrogenase activity
DOE78_RS19185	COG0123	including yeast histone deacetylase and acetoin utilization protein
DOE78_RS19205	COG1605	Chorismate mutase
DOE78_RS19205	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DOE78_RS19215	COG3118	belongs to the thioredoxin family
DOE78_RS19220	COG4980	gas vesicle protein
DOE78_RS19230	COG2309	aminopeptidase activity
DOE78_RS19235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DOE78_RS19250	COG1674	ftsk spoiiie
DOE78_RS19310	COG0510	thiamine kinase activity
DOE78_RS19315	COG1523	belongs to the glycosyl hydrolase 13 family
DOE78_RS19320	COG1597	lipid kinase activity
DOE78_RS19335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DOE78_RS19345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOE78_RS19350	COG4473	ABC transporter
DOE78_RS19355	COG1131	(ABC) transporter
DOE78_RS19365	COG1349	DNA-binding transcription factor activity
DOE78_RS19370	COG1187	pseudouridine synthase activity
DOE78_RS19375	COG2244	polysaccharide biosynthetic process
DOE78_RS19380	COG2081	HI0933 family
DOE78_RS19390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DOE78_RS19395	COG0495	leucyl-tRNA aminoacylation
DOE78_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS19405	COG2610	gluconate transmembrane transporter activity
DOE78_RS19410	COG3829	transcription factor binding
DOE78_RS19410	COG3290	protein histidine kinase activity
DOE78_RS19420	COG2814	Major facilitator Superfamily
DOE78_RS19435	COG1242	4 iron, 4 sulfur cluster binding
DOE78_RS19440	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DOE78_RS19450	COG2267	carboxylic ester hydrolase activity
DOE78_RS19455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DOE78_RS19460	COG4990	cell redox homeostasis
DOE78_RS19465	COG0367	asparagine synthase
DOE78_RS19470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DOE78_RS19475	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DOE78_RS19485	COG1506	peptidase
DOE78_RS19490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DOE78_RS19495	COG1116	anion transmembrane transporter activity
DOE78_RS19500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOE78_RS19505	COG0494	nUDIX hydrolase
DOE78_RS19525	COG0840	transmembrane signaling receptor activity
DOE78_RS19530	COG0783	Belongs to the Dps family
DOE78_RS19540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOE78_RS19545	COG1854	S-ribosylhomocysteine lyase activity
DOE78_RS19550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DOE78_RS19555	COG0288	reversible hydration of carbon dioxide
DOE78_RS19565	COG1271	oxidase subunit
DOE78_RS19570	COG1294	oxidase, subunit
DOE78_RS19575	COG4948	Mandelate Racemase Muconate Lactonizing
DOE78_RS19590	COG0659	secondary active sulfate transmembrane transporter activity
DOE78_RS19595	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DOE78_RS19600	COG0596	Alpha beta hydrolase
DOE78_RS19605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DOE78_RS19610	COG1169	isochorismate synthase
DOE78_RS19615	COG1575	Belongs to the MenA family. Type 1 subfamily
DOE78_RS19620	COG0058	SHG alpha-glucan phosphorylase activity
DOE78_RS19625	COG0297	glycogen (starch) synthase activity
DOE78_RS19630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DOE78_RS19635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DOE78_RS19770	COG1285	pathogenesis
DOE78_RS19775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DOE78_RS19795	COG0673	inositol 2-dehydrogenase activity
DOE78_RS19825	COG1082	Xylose isomerase domain protein TIM barrel
DOE78_RS19830	COG0673	inositol 2-dehydrogenase activity
DOE78_RS19835	COG1172	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS19840	COG1129	ABC transporter
DOE78_RS19850	COG1609	Transcriptional regulator
DOE78_RS19855	COG3279	Response regulator of the LytR AlgR family
DOE78_RS19860	COG0784	Response regulator, receiver
DOE78_RS19860	COG2205	protein histidine kinase activity
DOE78_RS19865	COG0861	Integral membrane protein TerC family
DOE78_RS19875	COG0205	6-phosphofructokinase activity
DOE78_RS19880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DOE78_RS19885	COG2226	methyltransferase
DOE78_RS19890	COG3883	PFAM NLP P60 protein
DOE78_RS19890	COG0791	NLP P60 protein
DOE78_RS19905	COG0561	phosphatase activity
DOE78_RS19910	COG0673	inositol 2-dehydrogenase activity
DOE78_RS19925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DOE78_RS19930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DOE78_RS19930	COG0574	Belongs to the PEP-utilizing enzyme family
DOE78_RS19950	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS19955	COG1063	alcohol dehydrogenase
DOE78_RS19965	COG3414	Phosphotransferase system galactitol-specific IIB component
DOE78_RS19970	COG3775	system Galactitol-specific IIC component
DOE78_RS19975	COG2213	PTS system mannitol-specific
DOE78_RS19975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOE78_RS19980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DOE78_RS19990	COG0022	dehydrogenase e1 component
DOE78_RS19990	COG0508	dehydrogenase complex catalyzes the overall conversion of
DOE78_RS19995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DOE78_RS20015	COG3732	PTS system glucitol sorbitol-specific
DOE78_RS20035	COG1349	DNA-binding transcription factor activity
DOE78_RS20040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS20045	COG1172	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS20050	COG1129	ABC transporter
DOE78_RS20055	COG1879	ABC-type sugar transport system periplasmic component
DOE78_RS20060	COG1082	Xylose isomerase domain protein TIM barrel
DOE78_RS20065	COG2207	Transcriptional regulator
DOE78_RS20065	COG1917	Cupin 2, conserved barrel domain protein
DOE78_RS20080	COG0395	ABC-type sugar transport system, permease component
DOE78_RS20085	COG1175	transmembrane transport
DOE78_RS20090	COG1653	transport
DOE78_RS20095	COG4753	response regulator
DOE78_RS20095	COG2207	Transcriptional regulator
DOE78_RS20100	COG2972	Histidine kinase
DOE78_RS20115	COG0726	polysaccharide deacetylase
DOE78_RS20120	COG1070	Carbohydrate kinase
DOE78_RS20125	COG2115	Belongs to the xylose isomerase family
DOE78_RS20145	COG1959	2 iron, 2 sulfur cluster binding
DOE78_RS20155	COG3711	transcriptional antiterminator
DOE78_RS20160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOE78_RS20160	COG2213	PTS system mannitol-specific
DOE78_RS20175	COG1733	regulation of RNA biosynthetic process
DOE78_RS20180	COG2207	Transcriptional regulator
DOE78_RS20185	COG1472	Belongs to the glycosyl hydrolase 3 family
DOE78_RS20195	COG3408	Glycogen debranching enzyme
DOE78_RS20205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOE78_RS20225	COG1472	Belongs to the glycosyl hydrolase 3 family
DOE78_RS20240	COG0439	Biotin carboxylase
DOE78_RS20245	COG3665	Urea carboxylase-associated protein
DOE78_RS20255	COG0531	amino acid
DOE78_RS20265	COG1305	Transglutaminase-like
DOE78_RS20270	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS20275	COG2080	2 iron, 2 sulfur cluster binding
DOE78_RS20280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DOE78_RS20285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DOE78_RS20290	COG2068	MobA-Related Protein
DOE78_RS20295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DOE78_RS20300	COG2814	Major facilitator Superfamily
DOE78_RS20305	COG1846	Transcriptional regulator
DOE78_RS20310	COG0840	transmembrane signaling receptor activity
DOE78_RS20315	COG1131	(ABC) transporter
DOE78_RS20355	COG5002	protein histidine kinase activity
DOE78_RS20360	COG0745	RESPONSE REGULATOR receiver
DOE78_RS20375	COG2223	nitrite transmembrane transporter activity
DOE78_RS20385	COG1132	(ABC) transporter
DOE78_RS20445	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS20450	COG0297	glycogen (starch) synthase activity
DOE78_RS20455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DOE78_RS20460	COG0463	Glycosyl transferase, family 2
DOE78_RS20460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DOE78_RS20465	COG1442	glycosyl transferase family 8
DOE78_RS20465	COG1216	Glycosyl transferase, family 2
DOE78_RS20475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DOE78_RS20480	COG0110	maltose O-acetyltransferase activity
DOE78_RS20485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DOE78_RS20490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DOE78_RS20495	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS20500	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS20510	COG1215	transferase activity, transferring glycosyl groups
DOE78_RS20515	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS20520	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS20525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DOE78_RS20530	COG1086	Polysaccharide biosynthesis protein
DOE78_RS20535	COG0489	protein tyrosine kinase activity
DOE78_RS20540	COG3944	biosynthesis protein
DOE78_RS20545	COG1132	(ABC) transporter
DOE78_RS20575	COG0367	asparagine synthase
DOE78_RS20585	COG2502	aspartate--ammonia ligase
DOE78_RS20590	COG0753	catalase activity
DOE78_RS20600	COG2814	Major facilitator Superfamily
DOE78_RS20605	COG2271	Major facilitator Superfamily
DOE78_RS20610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DOE78_RS20615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DOE78_RS20620	COG0640	Transcriptional regulator
DOE78_RS20630	COG0861	Integral membrane protein TerC family
DOE78_RS20640	COG1486	melibiose metabolic process
DOE78_RS20645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS20650	COG2188	Transcriptional regulator
DOE78_RS20660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DOE78_RS20665	COG2233	PERMEase
DOE78_RS20670	COG4335	DNA alkylation repair
DOE78_RS20685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DOE78_RS20690	COG1309	transcriptional regulator
DOE78_RS20695	COG1408	metallophosphoesterase
DOE78_RS20700	COG2353	YceI-like domain
DOE78_RS20705	COG1414	Transcriptional regulator
DOE78_RS20710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DOE78_RS20715	COG0768	penicillin binding
DOE78_RS20720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DOE78_RS20735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DOE78_RS20750	COG1979	alcohol dehydrogenase
DOE78_RS20755	COG2155	Conserved Protein
DOE78_RS20760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DOE78_RS20765	COG1098	S1 RNA binding domain
DOE78_RS20770	COG0733	neurotransmitter:sodium symporter activity
DOE78_RS20780	COG1307	EDD domain protein, DegV family
DOE78_RS20785	COG0436	Aminotransferase
DOE78_RS20790	COG1522	sequence-specific DNA binding
DOE78_RS20795	COG2267	carboxylic ester hydrolase activity
DOE78_RS20805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DOE78_RS20815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DOE78_RS20825	COG5018	Exonuclease
DOE78_RS20830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE78_RS20850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DOE78_RS20850	COG2111	Na H antiporter
DOE78_RS20855	COG2111	Na H antiporter
DOE78_RS20860	COG1006	Multisubunit Na H antiporter MnhC subunit
DOE78_RS20865	COG0651	ATP synthesis coupled electron transport
DOE78_RS20870	COG1863	multisubunit Na H antiporter MnhE subunit
DOE78_RS20875	COG2212	antiporter activity
DOE78_RS20880	COG1320	monovalent cation:proton antiporter activity
DOE78_RS20885	COG2050	protein possibly involved in aromatic compounds catabolism
DOE78_RS20890	COG0586	Pfam SNARE associated Golgi protein
DOE78_RS20920	COG1968	undecaprenyl-diphosphatase activity
DOE78_RS20925	COG0586	Pfam SNARE associated Golgi protein
DOE78_RS20930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DOE78_RS20935	COG2056	Na+-H+ antiporter family
DOE78_RS20940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DOE78_RS20950	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DOE78_RS20955	COG3584	3D domain protein
DOE78_RS20970	COG1252	NADH dehydrogenase
DOE78_RS20980	COG0316	Belongs to the HesB IscA family
DOE78_RS20990	COG4844	belongs to the
DOE78_RS20995	COG1252	NADH dehydrogenase
DOE78_RS21000	COG0514	ATP-dependent DNA helicase (RecQ)
DOE78_RS21005	COG4837	Protein of unknown function (DUF1462)
DOE78_RS21010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DOE78_RS21015	COG0083	homoserine kinase activity
DOE78_RS21020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DOE78_RS21025	COG0460	homoserine dehydrogenase
DOE78_RS21030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DOE78_RS21035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DOE78_RS21040	COG0647	UMP catabolic process
DOE78_RS21045	COG2445	Protein of unknown function DUF86
DOE78_RS21050	COG2200	EAL domain
DOE78_RS21050	COG2199	diguanylate cyclase activity
DOE78_RS21065	COG4470	Protein conserved in bacteria
DOE78_RS21080	COG0739	heme binding
DOE78_RS21090	COG0733	neurotransmitter:sodium symporter activity
DOE78_RS21105	COG3377	Domain of unknown function (DUF1805)
DOE78_RS21110	COG0737	Belongs to the 5'-nucleotidase family
DOE78_RS21115	COG1801	Protein of unknown function DUF72
DOE78_RS21120	COG0719	Fe-S assembly protein
DOE78_RS21125	COG0822	iron-sulfur transferase activity
DOE78_RS21130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DOE78_RS21135	COG0719	Fe-S assembly protein
DOE78_RS21140	COG0396	ATPase activity
DOE78_RS21145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DOE78_RS21150	COG1464	Belongs to the NlpA lipoprotein family
DOE78_RS21155	COG2011	ABC-type metal ion transport system permease component
DOE78_RS21160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DOE78_RS21165	COG2873	o-acetylhomoserine
DOE78_RS21175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOE78_RS21180	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DOE78_RS21190	COG0509	glycine decarboxylation via glycine cleavage system
DOE78_RS21195	COG1393	Belongs to the ArsC family
DOE78_RS21200	COG1960	acyl-CoA dehydrogenase activity
DOE78_RS21205	COG0183	Belongs to the thiolase family
DOE78_RS21210	COG1024	Enoyl-CoA hydratase
DOE78_RS21210	COG1250	3-hydroxyacyl-CoA dehydrogenase
DOE78_RS21240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOE78_RS21245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOE78_RS21250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DOE78_RS21255	COG0772	Belongs to the SEDS family
DOE78_RS21260	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOE78_RS21270	COG1028	Short-chain dehydrogenase reductase Sdr
DOE78_RS21290	COG1033	growth of symbiont in host cell
DOE78_RS21290	COG2409	Drug exporters of the RND superfamily
DOE78_RS21295	COG1846	Transcriptional regulator
DOE78_RS21310	COG1492	cobalamin metabolic process
DOE78_RS21340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DOE78_RS21345	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DOE78_RS21350	COG0129	dihydroxy-acid dehydratase activity
DOE78_RS21355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DOE78_RS21360	COG2011	ABC-type metal ion transport system permease component
DOE78_RS21365	COG1464	Belongs to the NlpA lipoprotein family
DOE78_RS21370	COG0371	Dehydrogenase
DOE78_RS21380	COG2217	Heavy metal translocating P-type atpase
DOE78_RS21385	COG2608	mercury ion transmembrane transporter activity
DOE78_RS21410	COG0667	Aldo Keto reductase
DOE78_RS21415	COG1979	alcohol dehydrogenase
DOE78_RS21430	COG0395	ABC-type sugar transport system, permease component
DOE78_RS21435	COG1175	transmembrane transport
DOE78_RS21440	COG1653	transport
DOE78_RS21445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DOE78_RS21450	COG2814	Major facilitator Superfamily
DOE78_RS21455	COG2723	6-phospho-beta-galactosidase activity
DOE78_RS21460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DOE78_RS21465	COG2723	6-phospho-beta-galactosidase activity
DOE78_RS21470	COG2188	Transcriptional regulator
DOE78_RS21475	COG2814	Major facilitator Superfamily
DOE78_RS21480	COG1263	PTS System
DOE78_RS21480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOE78_RS21485	COG4821	SIS domain
DOE78_RS21490	COG2188	Transcriptional regulator
DOE78_RS21495	COG0363	glucosamine-6-phosphate deaminase activity
DOE78_RS21500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DOE78_RS21505	COG3279	Response regulator of the LytR AlgR family
DOE78_RS21530	COG2364	Membrane
DOE78_RS21535	COG1486	melibiose metabolic process
DOE78_RS21550	COG3338	carbonate dehydratase activity
DOE78_RS21575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DOE78_RS21600	COG0656	L-ascorbic acid biosynthetic process
DOE78_RS21605	COG1757	Na H antiporter
DOE78_RS21610	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS21615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DOE78_RS21625	COG1012	belongs to the aldehyde dehydrogenase family
DOE78_RS21630	COG3829	transcription factor binding
DOE78_RS21630	COG3290	protein histidine kinase activity
DOE78_RS21665	COG0671	phosphoesterase, PA-phosphatase related
DOE78_RS21690	COG0662	Cupin 2, conserved barrel domain protein
DOE78_RS21700	COG5577	PFAM Coat F domain
DOE78_RS21715	COG5577	PFAM Coat F domain
DOE78_RS21720	COG1063	alcohol dehydrogenase
DOE78_RS21725	COG0395	ABC-type sugar transport system, permease component
DOE78_RS21745	COG1609	Transcriptional regulator
DOE78_RS21755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS21760	COG1621	beta-fructofuranosidase activity
DOE78_RS21770	COG0395	ABC-type sugar transport system, permease component
DOE78_RS21775	COG4209	transmembrane transport
DOE78_RS21785	COG2207	Transcriptional regulator
DOE78_RS21785	COG4753	response regulator
DOE78_RS21790	COG3275	phosphorelay sensor kinase activity
DOE78_RS21805	COG0561	phosphatase activity
DOE78_RS21820	COG1609	Transcriptional regulator
DOE78_RS21840	COG1595	DNA-templated transcription, initiation
DOE78_RS21845	COG1172	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS21850	COG1129	ABC transporter
DOE78_RS21860	COG1278	Cold shock
DOE78_RS21875	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DOE78_RS21885	COG2247	cell wall binding repeat
DOE78_RS21885	COG2385	sporulation resulting in formation of a cellular spore
DOE78_RS22040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DOE78_RS22045	COG0557	exoribonuclease II activity
DOE78_RS22050	COG1647	Serine aminopeptidase, S33
DOE78_RS22055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DOE78_RS22075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DOE78_RS22085	COG0126	phosphoglycerate kinase activity
DOE78_RS22105	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DOE78_RS22125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOE78_RS22135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DOE78_RS22140	COG1660	Displays ATPase and GTPase activities
DOE78_RS22145	COG1051	belongs to the nudix hydrolase family
DOE78_RS22150	COG0492	ferredoxin-NADP+ reductase activity
DOE78_RS22155	COG0457	Tetratricopeptide repeat
DOE78_RS22160	COG0140	phosphoribosyl-ATP diphosphatase activity
DOE78_RS22160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DOE78_RS22165	COG0107	imidazoleglycerol-phosphate synthase activity
DOE78_RS22170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DOE78_RS22175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DOE78_RS22180	COG0131	Imidazoleglycerol-phosphate dehydratase
DOE78_RS22185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DOE78_RS22190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DOE78_RS22195	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DOE78_RS22200	COG0110	maltose O-acetyltransferase activity
DOE78_RS22205	COG0546	phosphoglycolate phosphatase activity
DOE78_RS22210	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DOE78_RS22215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DOE78_RS22220	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DOE78_RS22225	COG1785	Belongs to the alkaline phosphatase family
DOE78_RS22230	COG1950	PFAM Membrane protein of
DOE78_RS22235	COG3595	metallopeptidase activity
DOE78_RS22245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DOE78_RS22250	COG0556	nucleotide-excision repair
DOE78_RS22270	COG2259	Doxx family
DOE78_RS22275	COG1846	Transcriptional regulator
DOE78_RS22280	COG0589	response to stress
DOE78_RS22285	COG0701	Predicted permease
DOE78_RS22295	COG3711	transcriptional antiterminator
DOE78_RS22300	COG2723	6-phospho-beta-galactosidase activity
DOE78_RS22305	COG2190	(PTS) system
DOE78_RS22305	COG1263	PTS System
DOE78_RS22305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOE78_RS22310	COG2723	6-phospho-beta-galactosidase activity
DOE78_RS22320	COG1253	flavin adenine dinucleotide binding
DOE78_RS22325	COG0789	Transcriptional regulator
DOE78_RS22335	COG3201	nicotinamide mononucleotide transporter
DOE78_RS22340	COG0494	nUDIX hydrolase
DOE78_RS22345	COG1335	isochorismatase
DOE78_RS22350	COG1757	Na H antiporter
DOE78_RS22355	COG2514	catechol 2,3-dioxygenase activity
DOE78_RS22360	COG1733	regulation of RNA biosynthetic process
DOE78_RS22390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DOE78_RS22395	COG0640	Transcriptional regulator
DOE78_RS22400	COG0640	Transcriptional regulator
DOE78_RS22405	COG1309	transcriptional regulator
DOE78_RS22410	COG0477	Major facilitator Superfamily
DOE78_RS22415	COG2814	Major facilitator Superfamily
DOE78_RS22420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DOE78_RS22435	COG2261	transglycosylase associated protein
DOE78_RS22450	COG2169	Transcriptional regulator
DOE78_RS22485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE78_RS22500	COG0477	Major facilitator Superfamily
DOE78_RS22515	COG1301	dicarboxylic acid transport
DOE78_RS22520	COG3290	protein histidine kinase activity
DOE78_RS22525	COG4565	transcriptional regulatory protein
DOE78_RS22530	COG0281	malic enzyme
DOE78_RS22545	COG0840	transmembrane signaling receptor activity
DOE78_RS22555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DOE78_RS22560	COG0698	ribose 5-phosphate isomerase
DOE78_RS22565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DOE78_RS22570	COG1063	alcohol dehydrogenase
DOE78_RS22580	COG1063	alcohol dehydrogenase
DOE78_RS22585	COG3775	system Galactitol-specific IIC component
DOE78_RS22590	COG3414	Phosphotransferase system galactitol-specific IIB component
DOE78_RS22605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOE78_RS22610	COG3409	Peptidoglycan-binding domain 1 protein
DOE78_RS22610	COG0793	Belongs to the peptidase S41A family
DOE78_RS22635	COG1621	beta-fructofuranosidase activity
DOE78_RS22640	COG0395	ABC-type sugar transport system, permease component
DOE78_RS22645	COG1175	transmembrane transport
DOE78_RS22680	COG4753	response regulator
DOE78_RS22680	COG2207	Transcriptional regulator
DOE78_RS22685	COG2972	Histidine kinase
DOE78_RS22695	COG0395	ABC-type sugar transport system, permease component
DOE78_RS22700	COG4209	transmembrane transport
DOE78_RS22705	COG4942	peptidase
DOE78_RS22710	COG2177	Part of the ABC transporter FtsEX involved in
DOE78_RS22715	COG2884	Cell division ATP-binding protein ftsE
DOE78_RS22730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOE78_RS22740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DOE78_RS22750	COG0653	protein targeting
DOE78_RS22755	COG3012	SEC-C Motif Domain Protein
DOE78_RS22755	COG1405	negative regulation of cell septum assembly
DOE78_RS22760	COG1879	ABC-type sugar transport system periplasmic component
DOE78_RS22765	COG1172	Belongs to the binding-protein-dependent transport system permease family
DOE78_RS22770	COG1129	ABC transporter
DOE78_RS22775	COG1869	D-ribose catabolic process
DOE78_RS22780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS22785	COG1609	Transcriptional regulator
DOE78_RS22800	COG2059	Chromate
DOE78_RS22805	COG2059	Chromate
DOE78_RS22810	COG1744	ABC transporter substrate-binding protein PnrA-like
DOE78_RS22815	COG0840	transmembrane signaling receptor activity
DOE78_RS22820	COG0673	inositol 2-dehydrogenase activity
DOE78_RS22875	COG1516	flagellar protein fliS
DOE78_RS22880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DOE78_RS22880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DOE78_RS22885	COG1334	flagellar protein FlaG
DOE78_RS22900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DOE78_RS22905	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DOE78_RS22915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DOE78_RS22920	COG1256	bacterial-type flagellum assembly
DOE78_RS22920	COG4786	Flagellar basal body rod
DOE78_RS22945	COG1040	competence protein
DOE78_RS22950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DOE78_RS22955	COG1307	EDD domain protein, DegV family
DOE78_RS22965	COG2197	response regulator
DOE78_RS22970	COG4585	Histidine kinase
DOE78_RS22975	COG1739	Uncharacterized protein family UPF0029
DOE78_RS22980	COG1316	TRANSCRIPTIONal
DOE78_RS22990	COG3307	-O-antigen
DOE78_RS23000	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS23025	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOE78_RS23025	COG2247	cell wall binding repeat
DOE78_RS23030	COG2385	sporulation resulting in formation of a cellular spore
DOE78_RS23030	COG2247	cell wall binding repeat
DOE78_RS23035	COG2247	cell wall binding repeat
DOE78_RS23035	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOE78_RS23050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DOE78_RS23105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOE78_RS23110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DOE78_RS23115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DOE78_RS23120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DOE78_RS23125	COG1404	Belongs to the peptidase S8 family
DOE78_RS23130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DOE78_RS23150	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOE78_RS23150	COG2247	cell wall binding repeat
DOE78_RS23155	COG2226	methyltransferase
DOE78_RS23165	COG1482	cell wall glycoprotein biosynthetic process
DOE78_RS23210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DOE78_RS23215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DOE78_RS23230	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS23235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DOE78_RS23245	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS23285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DOE78_RS23290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DOE78_RS23295	COG4464	protein tyrosine phosphatase activity
DOE78_RS23300	COG0489	protein tyrosine kinase activity
DOE78_RS23305	COG3944	biosynthesis protein
DOE78_RS23315	COG1388	LysM domain
DOE78_RS23315	COG0791	NLP P60 protein
DOE78_RS23330	COG0346	lactoylglutathione lyase activity
DOE78_RS23335	COG0768	penicillin binding
DOE78_RS23360	COG3853	Toxic anion resistance protein (TelA)
DOE78_RS23365	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DOE78_RS23370	COG0860	N-Acetylmuramoyl-L-alanine amidase
DOE78_RS23395	COG1404	Belongs to the peptidase S8 family
DOE78_RS23400	COG3764	Sortase (surface protein transpeptidase)
DOE78_RS23405	COG1940	carbohydrate kinase activity
DOE78_RS23410	COG1523	belongs to the glycosyl hydrolase 13 family
DOE78_RS23415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS23425	COG0366	Alpha amylase catalytic
DOE78_RS23435	COG0673	inositol 2-dehydrogenase activity
DOE78_RS23450	COG2207	Transcriptional regulator
DOE78_RS23450	COG4753	response regulator
DOE78_RS23455	COG2972	Histidine kinase
DOE78_RS23475	COG4715	Zinc finger, swim domain protein
DOE78_RS23480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DOE78_RS23490	COG1346	cytolysis
DOE78_RS23495	COG1380	Effector of murein hydrolase LrgA
DOE78_RS23500	COG0629	single-stranded DNA binding
DOE78_RS23530	COG4786	Flagellar basal body rod
DOE78_RS23535	COG4786	Flagellar basal body rod
DOE78_RS23540	COG1077	Cell shape determining protein MreB Mrl
DOE78_RS23545	COG1609	Transcriptional regulator
DOE78_RS23560	COG0517	IMP dehydrogenase activity
DOE78_RS23560	COG0617	tRNA 3'-terminal CCA addition
DOE78_RS23560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DOE78_RS23565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DOE78_RS23580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DOE78_RS23585	COG0405	Gamma-glutamyltransferase
DOE78_RS23590	COG0739	heme binding
DOE78_RS23600	COG2385	sporulation resulting in formation of a cellular spore
DOE78_RS23620	COG1007	ATP synthesis coupled electron transport
DOE78_RS23630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DOE78_RS23635	COG0713	ATP synthesis coupled electron transport
DOE78_RS23650	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DOE78_RS23655	COG0649	NAD binding
DOE78_RS23660	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOE78_RS23665	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOE78_RS23670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DOE78_RS23680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DOE78_RS23685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DOE78_RS23690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DOE78_RS23695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOE78_RS23700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DOE78_RS23705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOE78_RS23710	COG0356	it plays a direct role in the translocation of protons across the membrane
DOE78_RS23725	COG1404	Belongs to the peptidase S8 family
DOE78_RS23735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DOE78_RS23740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DOE78_RS23750	COG0698	ribose 5-phosphate isomerase
DOE78_RS23755	COG0840	transmembrane signaling receptor activity
DOE78_RS23765	COG1971	Probably functions as a manganese efflux pump
DOE78_RS23770	COG0009	L-threonylcarbamoyladenylate synthase
DOE78_RS23785	COG2890	protein-(glutamine-N5) methyltransferase activity
DOE78_RS23790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DOE78_RS23800	COG1435	thymidine kinase activity
DOE78_RS23810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DOE78_RS23815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DOE78_RS23820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DOE78_RS23825	COG0191	fructose-bisphosphate aldolase activity
DOE78_RS23830	COG2204	response regulator
DOE78_RS23835	COG4821	SIS domain
DOE78_RS23840	COG0504	CTP synthase activity
DOE78_RS23845	COG3343	RNA polymerase activity
DOE78_RS23850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DOE78_RS23850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DOE78_RS23850	COG1703	isobutyryl-CoA mutase activity
DOE78_RS23860	COG1960	acyl-CoA dehydrogenase activity
DOE78_RS23865	COG1960	acyl-CoA dehydrogenase activity
DOE78_RS23870	COG1250	3-hydroxyacyl-CoA dehydrogenase
DOE78_RS23875	COG0183	Belongs to the thiolase family
DOE78_RS23880	COG2181	nitrate reductase activity
DOE78_RS23880	COG0247	lactate metabolic process
DOE78_RS23885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOE78_RS23890	COG4294	response to UV
DOE78_RS23900	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DOE78_RS23905	COG0018	arginyl-trna synthetase
DOE78_RS23920	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DOE78_RS23925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOE78_RS23935	COG1994	Peptidase M50
DOE78_RS23945	COG3465	dGTPase activity
DOE78_RS23950	COG1078	dGTPase activity
DOE78_RS23955	COG4844	belongs to the
DOE78_RS23970	COG0280	phosphate acetyltransferase
DOE78_RS23975	COG3253	May function as heme-dependent peroxidase
DOE78_RS23980	COG3773	Cell wall hydrolase
DOE78_RS23990	COG2363	Small membrane protein
DOE78_RS24015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DOE78_RS24020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DOE78_RS24025	COG0314	molybdopterin synthase activity
DOE78_RS24030	COG0746	molybdenum cofactor guanylyltransferase activity
DOE78_RS24035	COG0351	phosphomethylpyrimidine kinase
DOE78_RS24040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DOE78_RS24045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DOE78_RS24045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DOE78_RS24050	COG0307	riboflavin synthase, alpha
DOE78_RS24055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DOE78_RS24070	COG1131	(ABC) transporter
DOE78_RS24075	COG0842	Transport permease protein
DOE78_RS24075	COG1511	domain protein
DOE78_RS24085	COG0561	phosphatase activity
DOE78_RS24105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DOE78_RS24110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DOE78_RS24115	COG0366	Alpha amylase catalytic
DOE78_RS24120	COG0492	ferredoxin-NADP+ reductase activity
DOE78_RS24125	COG1132	(ABC) transporter
DOE78_RS24130	COG1132	(ABC) transporter
DOE78_RS24135	COG0789	Transcriptional regulator
DOE78_RS24145	COG0535	radical SAM domain protein
DOE78_RS24150	COG4187	Peptidase family M20/M25/M40
DOE78_RS24155	COG0366	Alpha amylase catalytic
DOE78_RS24160	COG1960	acyl-CoA dehydrogenase activity
DOE78_RS24170	COG1187	pseudouridine synthase activity
DOE78_RS24175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DOE78_RS24180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DOE78_RS24190	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS24195	COG4682	membrane
DOE78_RS24205	COG4176	ABC-type proline glycine betaine transport system permease component
DOE78_RS24210	COG4175	Glycine betaine
DOE78_RS24210	COG0517	IMP dehydrogenase activity
DOE78_RS24215	COG1510	regulation of RNA biosynthetic process
DOE78_RS24230	COG1966	Carbon starvation protein
DOE78_RS24235	COG1459	type II secretion system
DOE78_RS24245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DOE78_RS24280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DOE78_RS24295	COG0590	tRNA wobble adenosine to inosine editing
DOE78_RS24300	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DOE78_RS24310	COG0745	RESPONSE REGULATOR receiver
DOE78_RS24315	COG5002	protein histidine kinase activity
DOE78_RS24320	COG1447	Phosphotransferase system cellobiose-specific component IIA
DOE78_RS24325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS24330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOE78_RS24345	COG1404	Belongs to the peptidase S8 family
DOE78_RS24355	COG2188	Transcriptional regulator
DOE78_RS24360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOE78_RS24365	COG2222	sugar isomerase
DOE78_RS24370	COG0531	amino acid
DOE78_RS24395	COG2188	Transcriptional regulator
DOE78_RS24400	COG0366	Alpha amylase catalytic
DOE78_RS24405	COG1263	PTS System
DOE78_RS24405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOE78_RS24410	COG4191	Histidine kinase
DOE78_RS24425	COG0737	Belongs to the 5'-nucleotidase family
DOE78_RS24435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DOE78_RS24440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DOE78_RS24445	COG1668	transmembrane transport
DOE78_RS24450	COG4555	ABC transporter
DOE78_RS24455	COG3279	Response regulator of the LytR AlgR family
DOE78_RS24500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DOE78_RS24505	COG1288	antiporter activity
DOE78_RS24525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DOE78_RS24535	COG5566	PFAM Mor transcription activator
DOE78_RS24540	COG3708	Transcriptional regulator
DOE78_RS24540	COG2207	Transcriptional regulator
DOE78_RS24545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DOE78_RS24555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOE78_RS24560	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DOE78_RS24565	COG4853	Protein conserved in bacteria
DOE78_RS24570	COG4863	YycH protein
DOE78_RS24575	COG5002	protein histidine kinase activity
DOE78_RS24580	COG0745	RESPONSE REGULATOR receiver
DOE78_RS24585	COG4942	peptidase
DOE78_RS24585	COG1388	LysM domain
DOE78_RS24605	COG0305	Participates in initiation and elongation during chromosome replication
DOE78_RS24610	COG0359	binds to the 23S rRNA
DOE78_RS24615	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DOE78_RS24620	COG4241	membrane
DOE78_RS24630	COG0629	single-stranded DNA binding
DOE78_RS24635	COG0360	Binds together with S18 to 16S ribosomal RNA
DOE78_RS24640	COG0438	transferase activity, transferring glycosyl groups
DOE78_RS24645	COG0671	phosphoesterase, PA-phosphatase related
DOE78_RS24650	COG0012	GTP binding
DOE78_RS24655	COG0243	molybdopterin cofactor binding
DOE78_RS24660	COG4481	Protein conserved in bacteria
DOE78_RS24665	COG0668	transmembrane transport
DOE78_RS24680	COG1475	DNA binding
DOE78_RS24685	COG1192	Involved in chromosome partitioning
DOE78_RS24695	COG1475	DNA binding
DOE78_RS24700	COG0357	Ribosomal RNA small subunit methyltransferase G
DOE78_RS24705	COG0445	tRNA wobble uridine modification
DOE78_RS24710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DOE78_RS24715	COG1847	R3H domain protein
DOE78_RS24720	COG0706	membrane insertase activity
DOE78_RS24725	COG0594	ribonuclease P activity