locus-tag	class	description
O6U12_RS00005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O6U12_RS00010	COG0322	excinuclease ABC activity
O6U12_RS00015	COG2222	sugar isomerase
O6U12_RS00020	COG1653	transport
O6U12_RS00035	COG2188	Transcriptional regulator
O6U12_RS00040	COG3842	ATPase activity
O6U12_RS00045	COG0527	aspartate kinase activity
O6U12_RS00060	COG0072	phenylalanine-tRNA ligase activity
O6U12_RS00060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_RS00070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_RS00085	COG2356	endonuclease I
O6U12_RS00095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O6U12_RS00100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O6U12_RS00105	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O6U12_RS00110	COG2068	MobA-Related Protein
O6U12_RS00115	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
O6U12_RS00120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O6U12_RS00125	COG2080	2 iron, 2 sulfur cluster binding
O6U12_RS00135	COG2351	hydroxyisourate hydrolase activity
O6U12_RS00140	COG3195	allantoin biosynthetic process
O6U12_RS00140	COG3648	Uricase
O6U12_RS00145	COG2233	PERMEase
O6U12_RS00150	COG2233	PERMEase
O6U12_RS00155	COG2508	Transcriptional regulator
O6U12_RS00160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O6U12_RS00170	COG1801	Protein of unknown function DUF72
O6U12_RS00175	COG0730	response to heat
O6U12_RS00180	COG0737	Belongs to the 5'-nucleotidase family
O6U12_RS00185	COG3377	Domain of unknown function (DUF1805)
O6U12_RS00195	COG0739	heme binding
O6U12_RS00200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O6U12_RS00210	COG4470	Protein conserved in bacteria
O6U12_RS00215	COG2445	Protein of unknown function DUF86
O6U12_RS00220	COG0647	UMP catabolic process
O6U12_RS00225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O6U12_RS00230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_RS00235	COG0460	homoserine dehydrogenase
O6U12_RS00240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O6U12_RS00245	COG0083	homoserine kinase activity
O6U12_RS00250	COG4946	Tricorn protease homolog
O6U12_RS00250	COG0823	Involved in the tonB-independent uptake of proteins
O6U12_RS00250	COG1506	peptidase
O6U12_RS00255	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O6U12_RS00260	COG4837	Protein of unknown function (DUF1462)
O6U12_RS00265	COG1252	NADH dehydrogenase
O6U12_RS00270	COG4844	belongs to the
O6U12_RS00275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O6U12_RS00280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O6U12_RS00285	COG0316	Belongs to the HesB IscA family
O6U12_RS00290	COG0456	acetyltransferase
O6U12_RS00295	COG2808	Putative FMN-binding domain
O6U12_RS00300	COG0516	GMP reductase activity
O6U12_RS00310	COG0492	ferredoxin-NADP+ reductase activity
O6U12_RS00315	COG1252	NADH dehydrogenase
O6U12_RS00330	COG3584	3D domain protein
O6U12_RS00335	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
O6U12_RS00340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O6U12_RS00345	COG2056	Na+-H+ antiporter family
O6U12_RS00350	COG1268	BioY protein
O6U12_RS00355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O6U12_RS00360	COG2819	hydrolase of the alpha beta superfamily
O6U12_RS00365	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS00370	COG1169	isochorismate synthase
O6U12_RS00375	COG1021	2,3-dihydroxybenzoate-AMP ligase
O6U12_RS00380	COG3433	isochorismatase activity
O6U12_RS00380	COG1535	isochorismatase
O6U12_RS00385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_RS00390	COG3251	PFAM MbtH domain protein
O6U12_RS00395	COG5634	Uncharacterized conserved protein (DUF2278)
O6U12_RS00400	COG0686	Belongs to the AlaDH PNT family
O6U12_RS00405	COG2508	Transcriptional regulator
O6U12_RS00405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O6U12_RS00410	COG4842	Belongs to the WXG100 family
O6U12_RS00415	COG5417	Belongs to the EsaB family
O6U12_RS00420	COG4499	WXG100 protein secretion system (Wss), protein YukC
O6U12_RS00425	COG1674	ftsk spoiiie
O6U12_RS00425	COG0433	COG0433 Predicted ATPase
O6U12_RS00430	COG1511	domain protein
O6U12_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS00445	COG1418	mRNA catabolic process
O6U12_RS00460	COG0628	permease
O6U12_RS00475	COG5506	Protein of unknown function (DUF1694)
O6U12_RS00480	COG1335	isochorismatase
O6U12_RS00485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
O6U12_RS00490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O6U12_RS00510	COG0142	geranyltranstransferase activity
O6U12_RS00520	COG4585	Histidine kinase
O6U12_RS00525	COG2197	response regulator
O6U12_RS00530	COG2050	protein possibly involved in aromatic compounds catabolism
O6U12_RS00535	COG1320	monovalent cation:proton antiporter activity
O6U12_RS00540	COG2212	antiporter activity
O6U12_RS00545	COG1863	multisubunit Na H antiporter MnhE subunit
O6U12_RS00550	COG0651	ATP synthesis coupled electron transport
O6U12_RS00555	COG1006	Multisubunit Na H antiporter MnhC subunit
O6U12_RS00560	COG2111	Na H antiporter
O6U12_RS00565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O6U12_RS00565	COG2111	Na H antiporter
O6U12_RS00575	COG3493	citrate carrier protein
O6U12_RS00585	COG1079	Belongs to the binding-protein-dependent transport system permease family
O6U12_RS00590	COG4603	Belongs to the binding-protein-dependent transport system permease family
O6U12_RS00595	COG3845	ABC transporter
O6U12_RS00600	COG1744	ABC transporter substrate-binding protein PnrA-like
O6U12_RS00605	COG4565	transcriptional regulatory protein
O6U12_RS00610	COG3290	protein histidine kinase activity
O6U12_RS00620	COG3011	Protein conserved in bacteria
O6U12_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O6U12_RS00630	COG2814	Major facilitator Superfamily
O6U12_RS00640	COG5018	Exonuclease
O6U12_RS00650	COG2205	protein histidine kinase activity
O6U12_RS00665	COG2267	carboxylic ester hydrolase activity
O6U12_RS00670	COG1522	sequence-specific DNA binding
O6U12_RS00675	COG0436	Aminotransferase
O6U12_RS00680	COG1098	S1 RNA binding domain
O6U12_RS00685	COG2155	Conserved Protein
O6U12_RS00690	COG1979	alcohol dehydrogenase
O6U12_RS00695	COG1979	alcohol dehydrogenase
O6U12_RS00700	COG0166	Belongs to the GPI family
O6U12_RS00715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O6U12_RS00730	COG2738	Putative neutral zinc metallopeptidase
O6U12_RS00735	COG1253	flavin adenine dinucleotide binding
O6U12_RS00740	COG0366	Alpha amylase catalytic
O6U12_RS00750	COG0432	Pfam Uncharacterised protein family UPF0047
O6U12_RS00770	COG0840	transmembrane signaling receptor activity
O6U12_RS00775	COG0840	transmembrane signaling receptor activity
O6U12_RS00780	COG0840	transmembrane signaling receptor activity
O6U12_RS00785	COG0840	transmembrane signaling receptor activity
O6U12_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS00790	COG3347	Dehydrogenase
O6U12_RS00795	COG1349	DNA-binding transcription factor activity
O6U12_RS00800	COG1070	Carbohydrate kinase
O6U12_RS00805	COG3254	rhamnose metabolic process
O6U12_RS00810	COG4806	L-rhamnose isomerase
O6U12_RS00815	COG0673	inositol 2-dehydrogenase activity
O6U12_RS00820	COG0628	permease
O6U12_RS00825	COG1968	undecaprenyl-diphosphatase activity
O6U12_RS00835	COG5553	Cysteine dioxygenase type I
O6U12_RS00840	COG0477	Major facilitator Superfamily
O6U12_RS00845	COG1705	Flagellar rod assembly protein muramidase FlgJ
O6U12_RS00850	COG4682	membrane
O6U12_RS00855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O6U12_RS00860	COG0569	domain protein
O6U12_RS00875	COG1510	regulation of RNA biosynthetic process
O6U12_RS00880	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS00885	COG1454	alcohol dehydrogenase
O6U12_RS00895	COG2318	DinB family
O6U12_RS00900	COG1585	Membrane protein implicated in regulation of membrane protease activity
O6U12_RS00905	COG2268	Band 7 protein
O6U12_RS00910	COG1247	-acetyltransferase
O6U12_RS00915	COG3859	Proton-coupled thiamine transporter YuaJ
O6U12_RS01040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O6U12_RS01045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O6U12_RS01050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O6U12_RS01055	COG0297	glycogen (starch) synthase activity
O6U12_RS01060	COG0058	SHG alpha-glucan phosphorylase activity
O6U12_RS01065	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
O6U12_RS01070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_RS01075	COG0438	transferase activity, transferring glycosyl groups
O6U12_RS01080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_RS01090	COG0438	transferase activity, transferring glycosyl groups
O6U12_RS01095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O6U12_RS01100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O6U12_RS01105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O6U12_RS01110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O6U12_RS01115	COG1169	isochorismate synthase
O6U12_RS01120	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O6U12_RS01125	COG0596	Alpha beta hydrolase
O6U12_RS01130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O6U12_RS01135	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_RS01140	COG4948	Mandelate Racemase Muconate Lactonizing
O6U12_RS01145	COG0803	Belongs to the bacterial solute-binding protein 9 family
O6U12_RS01150	COG1121	(ABC) transporter
O6U12_RS01155	COG1321	iron dependent repressor
O6U12_RS01155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O6U12_RS01160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O6U12_RS01170	COG1294	oxidase, subunit
O6U12_RS01175	COG1271	oxidase subunit
O6U12_RS01180	COG0254	rRNA binding
O6U12_RS01185	COG0288	reversible hydration of carbon dioxide
O6U12_RS01190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O6U12_RS01195	COG1854	S-ribosylhomocysteine lyase activity
O6U12_RS01210	COG0783	Belongs to the Dps family
O6U12_RS01215	COG4824	toxin secretion phage lysis holin
O6U12_RS01220	COG0494	nUDIX hydrolase
O6U12_RS01225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O6U12_RS01230	COG1116	anion transmembrane transporter activity
O6U12_RS01235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O6U12_RS01240	COG1506	peptidase
O6U12_RS01250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O6U12_RS01255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O6U12_RS01260	COG0367	asparagine synthase
O6U12_RS01265	COG1113	amino acid transport
O6U12_RS01270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O6U12_RS01275	COG2267	carboxylic ester hydrolase activity
O6U12_RS01285	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
O6U12_RS01290	COG1242	4 iron, 4 sulfur cluster binding
O6U12_RS01305	COG1725	Transcriptional regulator
O6U12_RS01310	COG1131	(ABC) transporter
O6U12_RS01325	COG1136	(ABC) transporter
O6U12_RS01330	COG0577	efflux transmembrane transporter activity
O6U12_RS01335	COG0745	RESPONSE REGULATOR receiver
O6U12_RS01340	COG2205	protein histidine kinase activity
O6U12_RS01345	COG1136	(ABC) transporter
O6U12_RS01350	COG0577	efflux transmembrane transporter activity
O6U12_RS01355	COG2433	Pfam Transposase IS66
O6U12_RS01360	COG2814	Major facilitator Superfamily
O6U12_RS01365	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_RS01365	COG2202	Pas domain
O6U12_RS01375	COG0495	leucyl-tRNA aminoacylation
O6U12_RS01380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O6U12_RS01385	COG1486	melibiose metabolic process
O6U12_RS01390	COG0395	ABC-type sugar transport system, permease component
O6U12_RS01395	COG1175	transmembrane transport
O6U12_RS01400	COG1653	transport
O6U12_RS01405	COG1609	Transcriptional regulator
O6U12_RS01410	COG1073	alpha beta
O6U12_RS01420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O6U12_RS01425	COG0156	8-amino-7-oxononanoate synthase activity
O6U12_RS01435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O6U12_RS01440	COG2124	cytochrome p450
O6U12_RS01445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O6U12_RS01450	COG0395	ABC-type sugar transport system, permease component
O6U12_RS01455	COG1653	transport
O6U12_RS01460	COG2207	Transcriptional regulator
O6U12_RS01465	COG4209	transmembrane transport
O6U12_RS01470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
O6U12_RS01475	COG1653	transport
O6U12_RS01480	COG0673	inositol 2-dehydrogenase activity
O6U12_RS01485	COG5578	integral membrane protein
O6U12_RS01495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O6U12_RS01500	COG2081	HI0933 family
O6U12_RS01505	COG2244	polysaccharide biosynthetic process
O6U12_RS01510	COG1187	pseudouridine synthase activity
O6U12_RS01515	COG1349	DNA-binding transcription factor activity
O6U12_RS01520	COG1131	(ABC) transporter
O6U12_RS01525	COG4473	ABC transporter
O6U12_RS01530	COG2252	PERMEase
O6U12_RS01535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O6U12_RS01540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O6U12_RS01545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O6U12_RS01555	COG1597	lipid kinase activity
O6U12_RS01560	COG1523	belongs to the glycosyl hydrolase 13 family
O6U12_RS01565	COG0510	thiamine kinase activity
O6U12_RS01575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O6U12_RS01580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_RS01585	COG0281	malic enzyme
O6U12_RS01590	COG5584	Small secreted protein
O6U12_RS01595	COG1363	Peptidase, m42
O6U12_RS01610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS01615	COG4848	Belongs to the UPF0354 family
O6U12_RS01620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_RS01625	COG1674	ftsk spoiiie
O6U12_RS01630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O6U12_RS01635	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
O6U12_RS01640	COG4980	gas vesicle protein
O6U12_RS01645	COG3118	belongs to the thioredoxin family
O6U12_RS01650	COG1605	Chorismate mutase
O6U12_RS01650	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
O6U12_RS01655	COG1609	Transcriptional regulator
O6U12_RS01660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O6U12_RS01665	COG1360	Flagellar Motor Protein
O6U12_RS01670	COG0123	including yeast histone deacetylase and acetoin utilization protein
O6U12_RS01675	COG0517	IMP dehydrogenase activity
O6U12_RS01680	COG0454	-acetyltransferase
O6U12_RS01685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O6U12_RS01690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O6U12_RS01705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O6U12_RS01735	COG3645	SOS response
O6U12_RS01735	COG3646	Phage regulatory protein
O6U12_RS01760	COG0305	Participates in initiation and elongation during chromosome replication
O6U12_RS01780	COG1598	PFAM Uncharacterised protein family UPF0150
O6U12_RS01885	COG5280	Phage tail tape measure protein TP901
O6U12_RS01885	COG3953	SLT domain
O6U12_RS01895	COG1705	Flagellar rod assembly protein muramidase FlgJ
O6U12_RS01900	COG5434	Belongs to the glycosyl hydrolase 28 family
O6U12_RS01925	COG4824	toxin secretion phage lysis holin
O6U12_RS01930	COG1388	LysM domain
O6U12_RS01930	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS01930	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS01945	COG0457	Tetratricopeptide repeat
O6U12_RS01955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O6U12_RS01960	COG2199	diguanylate cyclase activity
O6U12_RS01960	COG2203	Gaf domain
O6U12_RS01965	COG1956	GAF domain-containing protein
O6U12_RS01970	COG1309	transcriptional regulator
O6U12_RS01975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O6U12_RS01980	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
O6U12_RS01985	COG1114	Component of the transport system for branched-chain amino acids
O6U12_RS01990	COG1104	cysteine desulfurase activity
O6U12_RS01995	COG0301	tRNA thio-modification
O6U12_RS02005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O6U12_RS02010	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O6U12_RS02015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O6U12_RS02020	COG0616	signal peptide processing
O6U12_RS02025	COG1714	RDD family
O6U12_RS02035	COG3874	Sporulation protein YtfJ
O6U12_RS02040	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
O6U12_RS02045	COG0827	DNA restriction-modification system
O6U12_RS02055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O6U12_RS02060	COG0521	Mo-molybdopterin cofactor biosynthetic process
O6U12_RS02065	COG0137	argininosuccinate synthase activity
O6U12_RS02070	COG0165	Argininosuccinate lyase
O6U12_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS02085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O6U12_RS02090	COG0583	DNA-binding transcription factor activity
O6U12_RS02095	COG0454	-acetyltransferase
O6U12_RS02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_RS02105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_RS02110	COG0765	amino acid transport
O6U12_RS02115	COG0765	amino acid transport
O6U12_RS02120	COG1126	abc transporter atp-binding protein
O6U12_RS02125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_RS02130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O6U12_RS02135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_RS02140	COG0196	riboflavin kinase activity
O6U12_RS02150	COG0730	response to heat
O6U12_RS02155	COG4109	DRTGG domain
O6U12_RS02165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O6U12_RS02185	COG0587	DNA-directed DNA polymerase activity
O6U12_RS02190	COG0281	malic enzyme
O6U12_RS02195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O6U12_RS02200	COG0825	malonyl-CoA metabolic process
O6U12_RS02205	COG0205	6-phosphofructokinase activity
O6U12_RS02210	COG0469	pyruvate kinase activity
O6U12_RS02215	COG3030	protein affecting phage T7 exclusion by the F plasmid
O6U12_RS02220	COG0628	permease
O6U12_RS02225	COG2707	UPF0756 membrane protein
O6U12_RS02230	COG0372	Belongs to the citrate synthase family
O6U12_RS02235	COG0538	isocitrate dehydrogenase activity
O6U12_RS02240	COG0039	L-malate dehydrogenase activity
O6U12_RS02245	COG0745	RESPONSE REGULATOR receiver
O6U12_RS02250	COG5002	protein histidine kinase activity
O6U12_RS02255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O6U12_RS02255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O6U12_RS02260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O6U12_RS02265	COG1971	Probably functions as a manganese efflux pump
O6U12_RS02270	COG0237	dephospho-CoA kinase activity
O6U12_RS02275	COG0656	L-ascorbic acid biosynthetic process
O6U12_RS02280	COG2814	Major facilitator Superfamily
O6U12_RS02285	COG1733	regulation of RNA biosynthetic process
O6U12_RS02290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O6U12_RS02300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O6U12_RS02305	COG3611	Membrane attachment protein
O6U12_RS02310	COG1484	DNA-dependent DNA replication
O6U12_RS02315	COG0398	Pfam SNARE associated Golgi protein
O6U12_RS02325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O6U12_RS02330	COG1011	Hydrolase
O6U12_RS02335	COG3275	phosphorelay sensor kinase activity
O6U12_RS02340	COG3279	Response regulator of the LytR AlgR family
O6U12_RS02345	COG1380	Effector of murein hydrolase LrgA
O6U12_RS02350	COG1346	cytolysis
O6U12_RS02360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O6U12_RS02365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O6U12_RS02370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O6U12_RS02375	COG3326	Membrane
O6U12_RS02385	COG1363	Peptidase, m42
O6U12_RS02390	COG3507	Belongs to the glycosyl hydrolase 43 family
O6U12_RS02395	COG2160	L-arabinose isomerase activity
O6U12_RS02400	COG1069	ribulokinase activity
O6U12_RS02405	COG0235	Class ii aldolase
O6U12_RS02410	COG0647	UMP catabolic process
O6U12_RS02415	COG0371	Dehydrogenase
O6U12_RS02420	COG1653	transport
O6U12_RS02425	COG1175	transmembrane transport
O6U12_RS02430	COG0395	ABC-type sugar transport system, permease component
O6U12_RS02435	COG3534	alpha-L-arabinofuranosidase
O6U12_RS02440	COG1966	Carbon starvation protein
O6U12_RS02450	COG0346	lactoylglutathione lyase activity
O6U12_RS02455	COG0247	lactate metabolic process
O6U12_RS02460	COG0277	FAD linked oxidase domain protein
O6U12_RS02465	COG3835	regulator
O6U12_RS02475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O6U12_RS02485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O6U12_RS02490	COG0072	phenylalanine-tRNA ligase activity
O6U12_RS02490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_RS02495	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O6U12_RS02500	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
O6U12_RS02505	COG1286	toxin biosynthetic process
O6U12_RS02510	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O6U12_RS02510	COG1796	DNA polymerase
O6U12_RS02515	COG1193	negative regulation of DNA recombination
O6U12_RS02520	COG3766	membrane
O6U12_RS02525	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_RS02530	COG1309	transcriptional regulator
O6U12_RS02535	COG1024	Enoyl-CoA hydratase
O6U12_RS02540	COG2086	electron transfer activity
O6U12_RS02545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O6U12_RS02550	COG3534	alpha-L-arabinofuranosidase
O6U12_RS02555	COG3118	belongs to the thioredoxin family
O6U12_RS02560	COG0322	excinuclease ABC activity
O6U12_RS02565	COG0527	aspartate kinase activity
O6U12_RS02570	COG1719	4-vinyl reductase, 4VR
O6U12_RS02575	COG2009	succinate dehydrogenase
O6U12_RS02580	COG1053	succinate dehydrogenase
O6U12_RS02585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O6U12_RS02590	COG0824	Thioesterase
O6U12_RS02595	COG2197	response regulator
O6U12_RS02600	COG2856	Zn peptidase
O6U12_RS02610	COG1525	nuclease
O6U12_RS02615	COG3620	sequence-specific DNA binding
O6U12_RS02640	COG3646	Phage regulatory protein
O6U12_RS02640	COG3645	SOS response
O6U12_RS02670	COG5377	YqaJ viral recombinase family
O6U12_RS02675	COG3723	Recombinational DNA repair protein, rece pathway
O6U12_RS02680	COG3935	DnaD domain protein
O6U12_RS02685	COG1484	DNA-dependent DNA replication
O6U12_RS02695	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
O6U12_RS02725	COG1595	DNA-templated transcription, initiation
O6U12_RS02745	COG5484	DNA packaging
O6U12_RS02820	COG3953	SLT domain
O6U12_RS02820	COG5280	Phage tail tape measure protein TP901
O6U12_RS02825	COG0791	NLP P60 protein
O6U12_RS02825	COG1388	LysM domain
O6U12_RS02875	COG4824	toxin secretion phage lysis holin
O6U12_RS02880	COG1388	LysM domain
O6U12_RS02880	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS02880	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS02905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O6U12_RS02915	COG1846	Transcriptional regulator
O6U12_RS02920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O6U12_RS02925	COG5401	PFAM Sporulation and spore germination
O6U12_RS02930	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O6U12_RS02935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O6U12_RS02940	COG0622	Phosphoesterase
O6U12_RS02950	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
O6U12_RS02955	COG0454	-acetyltransferase
O6U12_RS02965	COG0028	Belongs to the TPP enzyme family
O6U12_RS02970	COG0440	acetolactate synthase activity
O6U12_RS02975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O6U12_RS02980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O6U12_RS02985	COG0473	3-isopropylmalate dehydrogenase activity
O6U12_RS02990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O6U12_RS02995	COG0066	3-isopropylmalate dehydratase activity
O6U12_RS03005	COG0457	Tetratricopeptide repeat
O6U12_RS03005	COG1477	protein flavinylation
O6U12_RS03010	COG0544	peptidyl-prolyl cis-trans isomerase activity
O6U12_RS03015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O6U12_RS03020	COG0470	DNA polymerase III
O6U12_RS03020	COG1067	ATP-dependent peptidase activity
O6U12_RS03025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O6U12_RS03030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O6U12_RS03040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O6U12_RS03045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O6U12_RS03050	COG0181	hydroxymethylbilane synthase activity
O6U12_RS03055	COG1587	Uroporphyrinogen-III synthase
O6U12_RS03060	COG0113	porphobilinogen synthase activity
O6U12_RS03065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O6U12_RS03070	COG1388	LysM domain
O6U12_RS03075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_RS03085	COG0525	valine-tRNA ligase activity
O6U12_RS03090	COG0285	dihydrofolate synthase activity
O6U12_RS03095	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O6U12_RS03105	COG0424	maF-like protein
O6U12_RS03110	COG2003	Belongs to the UPF0758 family
O6U12_RS03115	COG1077	Cell shape determining protein MreB Mrl
O6U12_RS03125	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O6U12_RS03130	COG0850	regulation of cytokinetic process
O6U12_RS03135	COG2894	cell division
O6U12_RS03140	COG0739	heme binding
O6U12_RS03145	COG1994	Peptidase M50
O6U12_RS03150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O6U12_RS03155	COG2868	ribosomal protein
O6U12_RS03160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O6U12_RS03170	COG3290	protein histidine kinase activity
O6U12_RS03175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O6U12_RS03180	COG4492	Belongs to the UPF0735 family
O6U12_RS03185	COG0077	Prephenate dehydratase
O6U12_RS03190	COG1827	regulation of RNA biosynthetic process
O6U12_RS03195	COG1104	cysteine desulfurase activity
O6U12_RS03200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O6U12_RS03205	COG0157	Belongs to the NadC ModD family
O6U12_RS03210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O6U12_RS03215	COG1388	LysM domain
O6U12_RS03225	COG0217	transcriptional regulatory protein
O6U12_RS03230	COG1115	amino acid carrier protein
O6U12_RS03255	COG2112	serine threonine protein kinase
O6U12_RS03260	COG0673	inositol 2-dehydrogenase activity
O6U12_RS03265	COG2814	Major facilitator Superfamily
O6U12_RS03275	COG0632	four-way junction helicase activity
O6U12_RS03280	COG2255	four-way junction helicase activity
O6U12_RS03290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O6U12_RS03295	COG0343	queuine tRNA-ribosyltransferase activity
O6U12_RS03300	COG1862	Preprotein translocase
O6U12_RS03310	COG2323	membrane
O6U12_RS03315	COG2244	polysaccharide biosynthetic process
O6U12_RS03325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O6U12_RS03325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O6U12_RS03330	COG0490	domain, Protein
O6U12_RS03335	COG5416	Lipopolysaccharide assembly protein A domain
O6U12_RS03340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O6U12_RS03340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
O6U12_RS03345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O6U12_RS03350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O6U12_RS03355	COG1490	D-aminoacyl-tRNA deacylase activity
O6U12_RS03360	COG4991	sh3 domain protein
O6U12_RS03360	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS03360	COG3103	Sh3 type 3 domain protein
O6U12_RS03370	COG0124	histidyl-tRNA synthetase
O6U12_RS03375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O6U12_RS03385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O6U12_RS03390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O6U12_RS03395	COG1959	2 iron, 2 sulfur cluster binding
O6U12_RS03400	COG1104	cysteine desulfurase activity
O6U12_RS03405	COG0482	sulfurtransferase activity
O6U12_RS03410	COG0457	Tetratricopeptide repeat
O6U12_RS03415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O6U12_RS03420	COG3881	PFAM PRC-barrel domain
O6U12_RS03435	COG0765	amino acid transport
O6U12_RS03440	COG0765	amino acid transport
O6U12_RS03445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_RS03450	COG1126	abc transporter atp-binding protein
O6U12_RS03455	COG0628	permease
O6U12_RS03460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O6U12_RS03465	COG4472	Bacterial protein of unknown function (DUF965)
O6U12_RS03470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O6U12_RS03475	COG3906	Belongs to the UPF0473 family
O6U12_RS03480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O6U12_RS03485	COG4122	O-methyltransferase activity
O6U12_RS03490	COG0826	peptidase U32
O6U12_RS03495	COG0826	peptidase U32
O6U12_RS03500	COG0572	uridine kinase
O6U12_RS03505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O6U12_RS03510	COG0768	penicillin binding
O6U12_RS03525	COG2226	methyltransferase
O6U12_RS03530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O6U12_RS03535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O6U12_RS03540	COG0626	cystathionine gamma-synthase activity
O6U12_RS03550	COG2427	Protein of unknown function (DUF1641)
O6U12_RS03555	COG3383	formate dehydrogenase (NAD+) activity
O6U12_RS03560	COG5609	conserved protein (DUF2294)
O6U12_RS03565	COG2116	formate transmembrane transporter activity
O6U12_RS03580	COG2226	methyltransferase
O6U12_RS03585	COG1309	transcriptional regulator
O6U12_RS03590	COG2124	cytochrome p450
O6U12_RS03590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O6U12_RS03600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O6U12_RS03600	COG2755	lipolytic protein G-D-S-L family
O6U12_RS03610	COG1595	DNA-templated transcription, initiation
O6U12_RS03615	COG1378	Sugar-specific transcriptional regulator TrmB
O6U12_RS03620	COG1280	lysine exporter protein (LysE YggA)
O6U12_RS03625	COG1113	amino acid transport
O6U12_RS03635	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O6U12_RS03635	COG3933	PFAM sigma-54 factor interaction domain-containing protein
O6U12_RS03640	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_RS03645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_RS03650	COG3715	PTS system
O6U12_RS03655	COG3716	PTS system mannose fructose sorbose family IID component
O6U12_RS03665	COG1621	beta-fructofuranosidase activity
O6U12_RS03670	COG0693	protein deglycase activity
O6U12_RS03675	COG1064	alcohol dehydrogenase
O6U12_RS03685	COG0789	Transcriptional regulator
O6U12_RS03695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O6U12_RS03700	COG2070	2-Nitropropane dioxygenase
O6U12_RS03710	COG3328	transposase activity
O6U12_RS03715	COG2318	DinB family
O6U12_RS03750	COG2124	cytochrome p450
O6U12_RS03755	COG2732	(Barnase) inhibitor
O6U12_RS03765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
O6U12_RS03770	COG1687	branched-chain amino acid
O6U12_RS03790	COG1230	cation diffusion facilitator family transporter
O6U12_RS03820	COG0583	DNA-binding transcription factor activity
O6U12_RS03855	COG1253	flavin adenine dinucleotide binding
O6U12_RS03860	COG0456	acetyltransferase
O6U12_RS03865	COG2814	Major facilitator Superfamily
O6U12_RS03870	COG0789	Transcriptional regulator
O6U12_RS03870	COG4978	Transcriptional regulator
O6U12_RS03885	COG0662	Cupin 2, conserved barrel domain protein
O6U12_RS03895	COG1937	Protein conserved in bacteria
O6U12_RS03900	COG2210	Belongs to the sulfur carrier protein TusA family
O6U12_RS03910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O6U12_RS03910	COG0425	Belongs to the sulfur carrier protein TusA family
O6U12_RS03925	COG0425	Belongs to the sulfur carrier protein TusA family
O6U12_RS03930	COG0730	response to heat
O6U12_RS03935	COG4124	Belongs to the glycosyl hydrolase 26 family
O6U12_RS03950	COG3328	transposase activity
O6U12_RS03960	COG2856	Zn peptidase
O6U12_RS03965	COG0563	adenylate kinase activity
O6U12_RS03975	COG3328	transposase activity
O6U12_RS04000	COG4824	toxin secretion phage lysis holin
O6U12_RS04005	COG1388	LysM domain
O6U12_RS04005	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS04005	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS04015	COG4282	regulation of fungal-type cell wall biogenesis
O6U12_RS04055	COG0457	Tetratricopeptide repeat
O6U12_RS04085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O6U12_RS04090	COG0477	Major facilitator Superfamily
O6U12_RS04130	COG0398	Pfam SNARE associated Golgi protein
O6U12_RS04135	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS04135	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS04140	COG2755	lipolytic protein G-D-S-L family
O6U12_RS04150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
O6U12_RS04155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O6U12_RS04160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O6U12_RS04165	COG1534	Rna-binding protein
O6U12_RS04170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O6U12_RS04175	COG1713	HD superfamily hydrolase involved in NAD metabolism
O6U12_RS04180	COG0799	negative regulation of ribosome biogenesis
O6U12_RS04185	COG2226	methyltransferase
O6U12_RS04190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O6U12_RS04195	COG1555	photosystem II stabilization
O6U12_RS04195	COG1596	polysaccharide export
O6U12_RS04200	COG2131	deaminase
O6U12_RS04205	COG0658	competence protein
O6U12_RS04205	COG2333	competence protein COMEC
O6U12_RS04220	COG1466	dna polymerase III delta subunit
O6U12_RS04225	COG0268	Binds directly to 16S ribosomal RNA
O6U12_RS04230	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
O6U12_RS04235	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS04245	COG0481	GTPase activity
O6U12_RS04250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O6U12_RS04255	COG1420	regulation of RNA biosynthetic process
O6U12_RS04260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O6U12_RS04265	COG0443	Heat shock 70 kDa protein
O6U12_RS04270	COG0484	heat shock protein binding
O6U12_RS04275	COG2264	protein methyltransferase activity
O6U12_RS04280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O6U12_RS04285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O6U12_RS04290	COG1283	sodium-dependent phosphate transmembrane transporter activity
O6U12_RS04300	COG1610	YqeY-like protein
O6U12_RS04305	COG1030	water channel activity
O6U12_RS04310	COG4864	UPF0365 protein
O6U12_RS04325	COG0561	phosphatase activity
O6U12_RS04330	COG1702	phosphate starvation-inducible protein PhoH
O6U12_RS04335	COG1480	7TM receptor with intracellular HD hydrolase
O6U12_RS04340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O6U12_RS04345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O6U12_RS04350	COG0295	cytidine deaminase activity
O6U12_RS04355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O6U12_RS04365	COG1381	Involved in DNA repair and RecF pathway recombination
O6U12_RS04370	COG0752	glycyl-tRNA synthetase alpha subunit
O6U12_RS04375	COG0751	glycine-tRNA ligase activity
O6U12_RS04380	COG0517	IMP dehydrogenase activity
O6U12_RS04385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O6U12_RS04390	COG1671	Belongs to the UPF0178 family
O6U12_RS04395	COG0358	DNA primase activity
O6U12_RS04400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O6U12_RS04405	COG2010	Cytochrome c
O6U12_RS04410	COG2384	SAM-dependent methyltransferase
O6U12_RS04415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O6U12_RS04420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O6U12_RS04430	COG0513	Belongs to the DEAD box helicase family
O6U12_RS04435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O6U12_RS04445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_RS04450	COG0735	belongs to the Fur family
O6U12_RS04455	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
O6U12_RS04460	COG4709	membrane
O6U12_RS04465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O6U12_RS04470	COG1388	LysM domain
O6U12_RS04475	COG5521	maltodextrose utilization protein MalA
O6U12_RS04480	COG2839	Protein conserved in bacteria
O6U12_RS04485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O6U12_RS04490	COG0477	Major facilitator Superfamily
O6U12_RS04495	COG0768	penicillin binding
O6U12_RS04500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O6U12_RS04505	COG0573	inorganic phosphate transmembrane transporter activity
O6U12_RS04510	COG0581	inorganic phosphate transmembrane transporter activity
O6U12_RS04515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O6U12_RS04520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O6U12_RS04525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O6U12_RS04540	COG0438	transferase activity, transferring glycosyl groups
O6U12_RS04550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O6U12_RS04560	COG0457	Tetratricopeptide repeat
O6U12_RS04560	COG0705	Rhomboid family
O6U12_RS04565	COG4483	Protein conserved in bacteria
O6U12_RS04570	COG1940	carbohydrate kinase activity
O6U12_RS04575	COG1368	sulfuric ester hydrolase activity
O6U12_RS04580	COG2866	Carboxypeptidase
O6U12_RS04590	COG0011	TIGRFAM Protein of
O6U12_RS04600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_RS04610	COG1393	Belongs to the ArsC family
O6U12_RS04620	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_RS04625	COG1253	flavin adenine dinucleotide binding
O6U12_RS04630	COG0598	Magnesium transport protein CorA
O6U12_RS04635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O6U12_RS04640	COG1459	type II secretion system
O6U12_RS04645	COG4537	Required for transformation and DNA binding
O6U12_RS04650	COG4970	Tfp pilus assembly protein FimT
O6U12_RS04660	COG4940	Competence protein ComGF
O6U12_RS04685	COG0681	Belongs to the peptidase S26 family
O6U12_RS04695	COG1396	sequence-specific DNA binding
O6U12_RS04710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O6U12_RS04715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O6U12_RS04720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O6U12_RS04725	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O6U12_RS04730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O6U12_RS04735	COG0095	Lipoate-protein ligase
O6U12_RS04740	COG1321	iron dependent repressor
O6U12_RS04745	COG1752	Esterase of the alpha-beta hydrolase superfamily
O6U12_RS04755	COG3872	metal-dependent enzyme
O6U12_RS04765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O6U12_RS04770	COG0006	proline dipeptidase activity
O6U12_RS04775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O6U12_RS04785	COG3854	ATPases associated with a variety of cellular activities
O6U12_RS04825	COG0511	ligase activity, forming carbon-carbon bonds
O6U12_RS04830	COG0439	Biotin carboxylase
O6U12_RS04835	COG1302	Protein conserved in bacteria
O6U12_RS04840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O6U12_RS04845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O6U12_RS04850	COG1570	exodeoxyribonuclease VII activity
O6U12_RS04855	COG1722	exodeoxyribonuclease VII activity
O6U12_RS04860	COG0142	geranyltranstransferase activity
O6U12_RS04865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O6U12_RS04870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
O6U12_RS04875	COG1438	arginine binding
O6U12_RS04880	COG0497	DNA recombination
O6U12_RS04885	COG0750	zinc metalloprotease
O6U12_RS04890	COG0745	RESPONSE REGULATOR receiver
O6U12_RS04895	COG1902	pentaerythritol trinitrate reductase activity
O6U12_RS04910	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS04915	COG0584	glycerophosphoryl diester phosphodiesterase
O6U12_RS04920	COG0183	Belongs to the thiolase family
O6U12_RS04925	COG1250	3-hydroxyacyl-CoA dehydrogenase
O6U12_RS04930	COG1960	acyl-CoA dehydrogenase activity
O6U12_RS04935	COG0372	Belongs to the citrate synthase family
O6U12_RS04940	COG2079	MmgE PrpD family protein
O6U12_RS04945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O6U12_RS04955	COG3290	protein histidine kinase activity
O6U12_RS04955	COG3829	transcription factor binding
O6U12_RS04960	COG0280	phosphate acetyltransferase
O6U12_RS04965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O6U12_RS04970	COG3426	butyrate kinase activity
O6U12_RS04975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O6U12_RS04980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O6U12_RS04985	COG0022	dehydrogenase e1 component
O6U12_RS04990	COG0508	dehydrogenase complex catalyzes the overall conversion of
O6U12_RS04995	COG0789	Transcriptional regulator
O6U12_RS04995	COG4978	Transcriptional regulator
O6U12_RS05000	COG2814	Major facilitator Superfamily
O6U12_RS05005	COG1597	lipid kinase activity
O6U12_RS05015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_RS05020	COG0765	amino acid transport
O6U12_RS05025	COG1126	abc transporter atp-binding protein
O6U12_RS05030	COG4129	membrane
O6U12_RS05035	COG1376	ErfK ybiS ycfS ynhG family protein
O6U12_RS05045	COG0346	lactoylglutathione lyase activity
O6U12_RS05050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O6U12_RS05055	COG2195	Cleaves the N-terminal amino acid of tripeptides
O6U12_RS05065	COG3361	conserved protein (COG2071)
O6U12_RS05070	COG0706	membrane insertase activity
O6U12_RS05080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O6U12_RS05085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O6U12_RS05090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O6U12_RS05095	COG1234	tRNA 3'-trailer cleavage
O6U12_RS05110	COG0596	Alpha beta hydrolase
O6U12_RS05115	COG1902	pentaerythritol trinitrate reductase activity
O6U12_RS05120	COG4187	Peptidase family M20/M25/M40
O6U12_RS05125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O6U12_RS05130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_RS05135	COG0300	oxidoreductase activity
O6U12_RS05140	COG3048	D-serine ammonia-lyase activity
O6U12_RS05145	COG1072	(Pantothenic acid kinase))
O6U12_RS05150	COG0346	lactoylglutathione lyase activity
O6U12_RS05160	COG2211	Major facilitator Superfamily
O6U12_RS05170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O6U12_RS05180	COG0456	acetyltransferase
O6U12_RS05185	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_RS05190	COG0456	acetyltransferase
O6U12_RS05190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O6U12_RS05195	COG4918	Iron-sulphur cluster biosynthesis
O6U12_RS05205	COG1073	alpha beta
O6U12_RS05215	COG0667	Aldo Keto reductase
O6U12_RS05225	COG0494	nUDIX hydrolase
O6U12_RS05230	COG1379	DNA repair
O6U12_RS05235	COG1396	sequence-specific DNA binding
O6U12_RS05240	COG0252	asparaginase activity
O6U12_RS05245	COG1027	Aspartate ammonia-lyase
O6U12_RS05250	COG1757	Na H antiporter
O6U12_RS05255	COG0281	malic enzyme
O6U12_RS05265	COG1300	Membrane
O6U12_RS05270	COG0735	belongs to the Fur family
O6U12_RS05280	COG4974	Belongs to the 'phage' integrase family
O6U12_RS05285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
O6U12_RS05290	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
O6U12_RS05295	COG1686	Belongs to the peptidase S11 family
O6U12_RS05300	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_RS05305	COG2172	sigma factor antagonist activity
O6U12_RS05310	COG1191	sigma factor activity
O6U12_RS05330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_RS05345	COG0697	spore germination
O6U12_RS05350	COG0019	diaminopimelate decarboxylase activity
O6U12_RS05355	COG4086	secreted protein
O6U12_RS05360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O6U12_RS05380	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
O6U12_RS05390	COG0681	Belongs to the peptidase S26 family
O6U12_RS05400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O6U12_RS05400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O6U12_RS05405	COG0307	riboflavin synthase, alpha
O6U12_RS05410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O6U12_RS05410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O6U12_RS05415	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O6U12_RS05420	COG0456	acetyltransferase
O6U12_RS05425	COG1547	Domain of unknown function (DUF309)
O6U12_RS05430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O6U12_RS05435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O6U12_RS05445	COG1686	Belongs to the peptidase S11 family
O6U12_RS05450	COG2715	membrane protein required for spore maturation
O6U12_RS05455	COG0700	Nucleoside recognition
O6U12_RS05460	COG1187	pseudouridine synthase activity
O6U12_RS05465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS05470	COG1333	cytochrome c biogenesis protein
O6U12_RS05475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O6U12_RS05480	COG0745	RESPONSE REGULATOR receiver
O6U12_RS05485	COG5002	protein histidine kinase activity
O6U12_RS05490	COG1595	DNA-templated transcription, initiation
O6U12_RS05500	COG0710	3-dehydroquinate dehydratase activity
O6U12_RS05505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O6U12_RS05510	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
O6U12_RS05515	COG1141	Ferredoxin
O6U12_RS05520	COG4955	Helix-turn-helix domain
O6U12_RS05525	COG0514	ATP-dependent DNA helicase (RecQ)
O6U12_RS05530	COG1266	CAAX protease self-immunity
O6U12_RS05535	COG1388	LysM domain
O6U12_RS05545	COG1408	metallophosphoesterase
O6U12_RS05550	COG4862	establishment of competence for transformation
O6U12_RS05555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O6U12_RS05560	COG0492	ferredoxin-NADP+ reductase activity
O6U12_RS05565	COG2339	peptidase activity
O6U12_RS05570	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS05570	COG3773	Cell wall hydrolase
O6U12_RS05575	COG2959	enzyme of heme biosynthesis
O6U12_RS05580	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
O6U12_RS05590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O6U12_RS05595	COG0539	negative regulation of cytoplasmic translation
O6U12_RS05600	COG1304	FMN binding
O6U12_RS05630	COG1160	GTP binding
O6U12_RS05635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O6U12_RS05650	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O6U12_RS05655	COG0776	regulation of translation
O6U12_RS05660	COG0302	gtp cyclohydrolase
O6U12_RS05670	COG0142	geranyltranstransferase activity
O6U12_RS05675	COG2226	methyltransferase
O6U12_RS05680	COG0142	geranyltranstransferase activity
O6U12_RS05685	COG0105	UTP biosynthetic process
O6U12_RS05690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O6U12_RS05695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O6U12_RS05700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O6U12_RS05705	COG4401	Chorismate mutase type I
O6U12_RS05710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O6U12_RS05715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O6U12_RS05725	COG0135	phosphoribosylanthranilate isomerase activity
O6U12_RS05730	COG0133	tryptophan synthase activity
O6U12_RS05735	COG0159	tryptophan synthase activity
O6U12_RS05745	COG0287	Prephenate dehydrogenase
O6U12_RS05750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O6U12_RS05755	COG0457	Tetratricopeptide repeat
O6U12_RS05760	COG5582	Belongs to the UPF0302 family
O6U12_RS05770	COG0723	plastoquinol--plastocyanin reductase activity
O6U12_RS05775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O6U12_RS05780	COG2010	Cytochrome c
O6U12_RS05780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O6U12_RS05785	COG4347	Protein of unknown function (DUF1405)
O6U12_RS05795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_RS05800	COG1694	Mazg nucleotide pyrophosphohydrolase
O6U12_RS05805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O6U12_RS05810	COG1803	Methylglyoxal synthase
O6U12_RS05815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O6U12_RS05820	COG0438	transferase activity, transferring glycosyl groups
O6U12_RS05825	COG0617	tRNA 3'-terminal CCA addition
O6U12_RS05830	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
O6U12_RS05830	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
O6U12_RS05835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O6U12_RS05840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O6U12_RS05845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O6U12_RS05850	COG1199	ATP-dependent helicase activity
O6U12_RS05850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O6U12_RS05860	COG5353	protein conserved in bacteria
O6U12_RS05865	COG0436	Aminotransferase
O6U12_RS05870	COG0017	Asparaginyl-tRNA synthetase
O6U12_RS05875	COG3935	DnaD domain protein
O6U12_RS05880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O6U12_RS05890	COG4499	WXG100 protein secretion system (Wss), protein YukC
O6U12_RS05890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O6U12_RS05895	COG3331	DNA recombination
O6U12_RS05930	COG0071	Belongs to the small heat shock protein (HSP20) family
O6U12_RS05935	COG2190	(PTS) system
O6U12_RS05940	COG1205	dead DEAH box helicase
O6U12_RS05940	COG1111	helicase
O6U12_RS05945	COG3359	exonuclease
O6U12_RS05960	COG4474	Belongs to the UPF0398 family
O6U12_RS05975	COG0116	Belongs to the methyltransferase superfamily
O6U12_RS05990	COG1199	ATP-dependent helicase activity
O6U12_RS05995	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS06000	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
O6U12_RS06005	COG1609	Transcriptional regulator
O6U12_RS06010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O6U12_RS06015	COG0800	Aldolase
O6U12_RS06025	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O6U12_RS06030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O6U12_RS06135	COG3328	transposase activity
O6U12_RS06140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O6U12_RS06180	COG1196	nuclear chromosome segregation
O6U12_RS06180	COG0741	lytic transglycosylase activity
O6U12_RS06180	COG0739	heme binding
O6U12_RS06185	COG3328	transposase activity
O6U12_RS06190	COG0741	lytic transglycosylase activity
O6U12_RS06190	COG1196	nuclear chromosome segregation
O6U12_RS06190	COG0739	heme binding
O6U12_RS06195	COG2433	Pfam Transposase IS66
O6U12_RS06250	COG3424	synthase
O6U12_RS06255	COG1755	Isoprenylcysteine carboxyl methyltransferase
O6U12_RS06265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O6U12_RS06280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O6U12_RS06290	COG0328	RNA-DNA hybrid ribonuclease activity
O6U12_RS06295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O6U12_RS06300	COG0328	RNA-DNA hybrid ribonuclease activity
O6U12_RS06320	COG1278	Cold shock
O6U12_RS06330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O6U12_RS06335	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O6U12_RS06340	COG0386	Belongs to the glutathione peroxidase family
O6U12_RS06350	COG1413	lyase activity
O6U12_RS06355	COG0129	dihydroxy-acid dehydratase activity
O6U12_RS06365	COG2136	Putative SAM-dependent methyltransferase
O6U12_RS06365	COG2521	methyltransferase
O6U12_RS06375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O6U12_RS06380	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O6U12_RS06385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O6U12_RS06390	COG0204	Acyl-transferase
O6U12_RS06395	COG1272	protein, Hemolysin III
O6U12_RS06400	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O6U12_RS06405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O6U12_RS06415	COG1999	signal sequence binding
O6U12_RS06420	COG2755	lipolytic protein G-D-S-L family
O6U12_RS06425	COG4698	Protein conserved in bacteria
O6U12_RS06435	COG0534	Mate efflux family protein
O6U12_RS06440	COG1846	Transcriptional regulator
O6U12_RS06445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O6U12_RS06450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O6U12_RS06455	COG1086	Polysaccharide biosynthesis protein
O6U12_RS06460	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
O6U12_RS06465	COG4641	Protein conserved in bacteria
O6U12_RS06480	COG0463	Glycosyl transferase, family 2
O6U12_RS06485	COG0456	acetyltransferase
O6U12_RS06500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O6U12_RS06505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O6U12_RS06510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O6U12_RS06515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O6U12_RS06520	COG0456	acetyltransferase
O6U12_RS06525	COG1509	lysine 2,3-aminomutase activity
O6U12_RS06535	COG4479	Belongs to the UPF0346 family
O6U12_RS06555	COG0671	phosphoesterase, PA-phosphatase related
O6U12_RS06570	COG0813	purine-nucleoside phosphorylase activity
O6U12_RS06575	COG1876	peptidase activity
O6U12_RS06585	COG2226	methyltransferase
O6U12_RS06590	COG0793	Belongs to the peptidase S41A family
O6U12_RS06590	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS06595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_RS06605	COG0346	lactoylglutathione lyase activity
O6U12_RS06610	COG0400	carboxylic ester hydrolase activity
O6U12_RS06615	COG0778	Nitroreductase
O6U12_RS06620	COG1733	regulation of RNA biosynthetic process
O6U12_RS06625	COG1942	4-Oxalocrotonate Tautomerase
O6U12_RS06630	COG2610	gluconate transmembrane transporter activity
O6U12_RS06645	COG2962	Rard protein
O6U12_RS06655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O6U12_RS06660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O6U12_RS06665	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_RS06675	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O6U12_RS06680	COG1819	glycosyl
O6U12_RS06685	COG1388	LysM domain
O6U12_RS06685	COG0791	NLP P60 protein
O6U12_RS06690	COG2032	superoxide dismutase activity
O6U12_RS06695	COG0714	Associated with various cellular activities
O6U12_RS06700	COG4548	von Willebrand factor, type A
O6U12_RS06705	COG0567	Dehydrogenase, E1 component
O6U12_RS06710	COG0508	dehydrogenase complex catalyzes the overall conversion of
O6U12_RS06715	COG0385	Bile acid
O6U12_RS06720	COG0733	neurotransmitter:sodium symporter activity
O6U12_RS06725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O6U12_RS06730	COG1657	PFAM Prenyltransferase squalene oxidase
O6U12_RS06735	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS06760	COG0071	Belongs to the small heat shock protein (HSP20) family
O6U12_RS06775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O6U12_RS06780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O6U12_RS06790	COG0514	ATP-dependent DNA helicase (RecQ)
O6U12_RS06795	COG1388	LysM domain
O6U12_RS06795	COG3584	3D domain protein
O6U12_RS06800	COG2197	response regulator
O6U12_RS06805	COG4585	Histidine kinase
O6U12_RS06810	COG3239	Fatty acid desaturase
O6U12_RS06815	COG1619	proteins homologs of microcin C7 resistance protein MccF
O6U12_RS06830	COG2322	membrane
O6U12_RS06840	COG0741	lytic transglycosylase activity
O6U12_RS06845	COG0640	Transcriptional regulator
O6U12_RS06855	COG2378	regulation of single-species biofilm formation
O6U12_RS06860	COG3708	Transcriptional regulator
O6U12_RS06865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_RS06870	COG1309	transcriptional regulator
O6U12_RS06875	COG0456	acetyltransferase
O6U12_RS06880	COG0662	Cupin 2, conserved barrel domain protein
O6U12_RS06880	COG2207	Transcriptional regulator
O6U12_RS06885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_RS06895	COG1231	oxidoreductase activity
O6U12_RS06900	COG4282	regulation of fungal-type cell wall biogenesis
O6U12_RS06905	COG5444	nuclease activity
O6U12_RS06920	COG0693	protein deglycase activity
O6U12_RS06925	COG3328	transposase activity
O6U12_RS06935	COG0697	spore germination
O6U12_RS06940	COG0583	DNA-binding transcription factor activity
O6U12_RS06945	COG3739	integral membrane protein
O6U12_RS06960	COG2720	vancomycin resistance protein
O6U12_RS07000	COG2135	peptidase activity
O6U12_RS07010	COG3619	membrane
O6U12_RS07015	COG4305	rare lipoprotein A
O6U12_RS07020	COG2368	4-hydroxyphenylacetate
O6U12_RS07025	COG5278	phosphoserine phosphatase activity
O6U12_RS07025	COG0840	transmembrane signaling receptor activity
O6U12_RS07060	COG3328	transposase activity
O6U12_RS07075	COG0243	molybdopterin cofactor binding
O6U12_RS07080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O6U12_RS07085	COG1070	Carbohydrate kinase
O6U12_RS07090	COG2814	Major facilitator Superfamily
O6U12_RS07095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_RS07105	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
O6U12_RS07110	COG0300	oxidoreductase activity
O6U12_RS07120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O6U12_RS07125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O6U12_RS07130	COG0583	DNA-binding transcription factor activity
O6U12_RS07135	COG0067	glutamate synthase
O6U12_RS07135	COG0069	glutamate synthase activity
O6U12_RS07135	COG0070	glutamate synthase
O6U12_RS07140	COG0493	'glutamate synthase
O6U12_RS07145	COG0604	alcohol dehydrogenase
O6U12_RS07150	COG0583	DNA-binding transcription factor activity
O6U12_RS07155	COG0405	Gamma-glutamyltransferase
O6U12_RS07160	COG0166	Belongs to the GPI family
O6U12_RS07165	COG0582	viral genome integration into host DNA
O6U12_RS07175	COG3328	transposase activity
O6U12_RS07185	COG0534	Mate efflux family protein
O6U12_RS07190	COG2017	converts alpha-aldose to the beta-anomer
O6U12_RS07195	COG2027	D-alanyl-D-alanine carboxypeptidase
O6U12_RS07215	COG1649	PFAM Uncharacterised BCR, COG1649
O6U12_RS07230	COG1960	acyl-CoA dehydrogenase activity
O6U12_RS07235	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_RS07240	COG0439	Biotin carboxylase
O6U12_RS07245	COG0511	ligase activity, forming carbon-carbon bonds
O6U12_RS07250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O6U12_RS07255	COG1024	Enoyl-CoA hydratase
O6U12_RS07260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O6U12_RS07265	COG2404	hydrolase activity, acting on ester bonds
O6U12_RS07270	COG0586	Pfam SNARE associated Golgi protein
O6U12_RS07275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O6U12_RS07280	COG2246	polysaccharide biosynthetic process
O6U12_RS07285	COG3507	Belongs to the glycosyl hydrolase 43 family
O6U12_RS07300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
O6U12_RS07305	COG1115	amino acid carrier protein
O6U12_RS07320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O6U12_RS07325	COG0187	DNA topoisomerase II activity
O6U12_RS07330	COG1832	CoA-binding protein
O6U12_RS07335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O6U12_RS07340	COG4841	protein insertion into membrane
O6U12_RS07350	COG0824	Thioesterase
O6U12_RS07370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS07375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O6U12_RS07390	COG0071	Belongs to the small heat shock protein (HSP20) family
O6U12_RS07405	COG4846	Membrane protein involved in cytochrome C biogenesis
O6U12_RS07410	COG2201	protein-glutamate methylesterase activity
O6U12_RS07415	COG0785	Cytochrome C biogenesis protein
O6U12_RS07425	COG3763	UPF0154 protein
O6U12_RS07435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O6U12_RS07440	COG4224	UPF0291 protein
O6U12_RS07445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O6U12_RS07450	COG1388	LysM domain
O6U12_RS07455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O6U12_RS07465	COG0346	lactoylglutathione lyase activity
O6U12_RS07475	COG4195	phage-related replication protein
O6U12_RS07505	COG0531	amino acid
O6U12_RS07510	COG0697	spore germination
O6U12_RS07525	COG3832	glyoxalase III activity
O6U12_RS07540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O6U12_RS07580	COG0756	dUTP diphosphatase activity
O6U12_RS07590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O6U12_RS07595	COG2814	Major facilitator Superfamily
O6U12_RS07600	COG1525	nuclease
O6U12_RS07615	COG1070	Carbohydrate kinase
O6U12_RS07620	COG2115	Belongs to the xylose isomerase family
O6U12_RS07625	COG1940	carbohydrate kinase activity
O6U12_RS07630	COG3507	Belongs to the glycosyl hydrolase 43 family
O6U12_RS07635	COG2211	Major facilitator Superfamily
O6U12_RS07640	COG3328	transposase activity
O6U12_RS07645	COG0135	phosphoribosylanthranilate isomerase activity
O6U12_RS07670	COG3655	Transcriptional regulator
O6U12_RS07710	COG3328	transposase activity
O6U12_RS07720	COG4282	regulation of fungal-type cell wall biogenesis
O6U12_RS07745	COG5444	nuclease activity
O6U12_RS07755	COG1388	LysM domain
O6U12_RS07755	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS07755	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS07760	COG4824	toxin secretion phage lysis holin
O6U12_RS07780	COG5434	Belongs to the glycosyl hydrolase 28 family
O6U12_RS07785	COG1705	Flagellar rod assembly protein muramidase FlgJ
O6U12_RS07795	COG3953	SLT domain
O6U12_RS07795	COG5280	Phage tail tape measure protein TP901
O6U12_RS07900	COG0582	viral genome integration into host DNA
O6U12_RS07920	COG0305	Participates in initiation and elongation during chromosome replication
O6U12_RS07945	COG3646	Phage regulatory protein
O6U12_RS07945	COG3645	SOS response
O6U12_RS07965	COG1396	sequence-specific DNA binding
O6U12_RS07980	COG0174	glutamine synthetase
O6U12_RS07985	COG0789	Transcriptional regulator
O6U12_RS07990	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
O6U12_RS07995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O6U12_RS08000	COG0464	growth
O6U12_RS08005	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS08010	COG4112	unkown
O6U12_RS08015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O6U12_RS08020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O6U12_RS08025	COG1780	Probably involved in ribonucleotide reductase function
O6U12_RS08040	COG1923	regulation of RNA biosynthetic process
O6U12_RS08045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O6U12_RS08060	COG2076	Multidrug Resistance protein
O6U12_RS08065	COG2076	Multidrug Resistance protein
O6U12_RS08070	COG1764	response to oxidative stress
O6U12_RS08075	COG4195	phage-related replication protein
O6U12_RS08085	COG1404	Belongs to the peptidase S8 family
O6U12_RS08090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_RS08100	COG3226	Transcriptional regulator
O6U12_RS08115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O6U12_RS08120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O6U12_RS08130	COG4550	Control of competence regulator ComK, YlbF/YmcA
O6U12_RS08135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O6U12_RS08140	COG0156	8-amino-7-oxononanoate synthase activity
O6U12_RS08145	COG1063	alcohol dehydrogenase
O6U12_RS08150	COG2359	stage V sporulation protein S
O6U12_RS08155	COG1692	metallophosphoesterase
O6U12_RS08160	COG1418	mRNA catabolic process
O6U12_RS08165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O6U12_RS08170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O6U12_RS08175	COG1058	Belongs to the CinA family
O6U12_RS08175	COG1546	Belongs to the CinA family
O6U12_RS08180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O6U12_RS08185	COG1426	Protein conserved in bacteria
O6U12_RS08200	COG0300	oxidoreductase activity
O6U12_RS08205	COG0612	Peptidase, M16
O6U12_RS08210	COG0612	Peptidase, M16
O6U12_RS08215	COG2814	Major facilitator Superfamily
O6U12_RS08220	COG2188	Transcriptional regulator
O6U12_RS08225	COG1674	ftsk spoiiie
O6U12_RS08225	COG4980	gas vesicle protein
O6U12_RS08235	COG0740	serine-type endopeptidase activity
O6U12_RS08240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O6U12_RS08245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O6U12_RS08250	COG0527	aspartate kinase activity
O6U12_RS08255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O6U12_RS08260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O6U12_RS08265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O6U12_RS08270	COG1873	PFAM PRC-barrel domain
O6U12_RS08275	COG0612	Peptidase, M16
O6U12_RS08280	COG0726	polysaccharide deacetylase
O6U12_RS08285	COG1185	polyribonucleotide nucleotidyltransferase activity
O6U12_RS08290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O6U12_RS08295	COG0196	riboflavin kinase activity
O6U12_RS08300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O6U12_RS08305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O6U12_RS08310	COG1550	Protein conserved in bacteria
O6U12_RS08315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O6U12_RS08320	COG1358	cellular component organization or biogenesis
O6U12_RS08325	COG2740	Nucleic-acid-binding protein implicated in transcription termination
O6U12_RS08330	COG0195	Participates in both transcription termination and antitermination
O6U12_RS08335	COG0779	Required for maturation of 30S ribosomal subunits
O6U12_RS08340	COG2176	DNA-directed DNA polymerase activity
O6U12_RS08345	COG0442	prolyl-tRNA aminoacylation
O6U12_RS08350	COG0750	zinc metalloprotease
O6U12_RS08355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O6U12_RS08360	COG4589	Belongs to the CDS family
O6U12_RS08365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O6U12_RS08370	COG0233	cytoplasmic translational termination
O6U12_RS08375	COG0528	UMP kinase activity
O6U12_RS08380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O6U12_RS08385	COG0052	Belongs to the universal ribosomal protein uS2 family
O6U12_RS08395	COG1191	sigma factor activity
O6U12_RS08400	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O6U12_RS08405	COG1776	CheC inhibitor of MCP methylation
O6U12_RS08410	COG0835	chemotaxis
O6U12_RS08415	COG0643	Histidine kinase
O6U12_RS08415	COG2198	Histidine kinase
O6U12_RS08420	COG2201	protein-glutamate methylesterase activity
O6U12_RS08425	COG0455	bacterial-type flagellum organization
O6U12_RS08430	COG1419	protein localization to endoplasmic reticulum
O6U12_RS08435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O6U12_RS08440	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O6U12_RS08445	COG1684	flagellar biosynthetic protein fliR
O6U12_RS08450	COG1987	bacterial-type flagellum assembly
O6U12_RS08455	COG1338	Plays a role in the flagellum-specific transport system
O6U12_RS08460	COG3190	flagellar
O6U12_RS08465	COG2201	protein-glutamate methylesterase activity
O6U12_RS08470	COG1776	CheC inhibitor of MCP methylation
O6U12_RS08470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O6U12_RS08475	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O6U12_RS08480	COG1580	Controls the rotational direction of flagella during chemotaxis
O6U12_RS08485	COG1582	Flagellar protein (FlbD)
O6U12_RS08490	COG4786	Flagellar basal body rod
O6U12_RS08495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O6U12_RS08500	COG3144	bacterial-type flagellum assembly
O6U12_RS08505	COG3334	PFAM MgtE intracellular
O6U12_RS08510	COG2882	bacterial-type flagellum organization
O6U12_RS08515	COG1157	protein secretion by the type III secretion system
O6U12_RS08520	COG1317	bacterial-type flagellum organization
O6U12_RS08525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O6U12_RS08530	COG1766	The M ring may be actively involved in energy transduction
O6U12_RS08535	COG1677	Flagellar hook-basal body complex protein FliE
O6U12_RS08540	COG1558	bacterial-type flagellum-dependent cell motility
O6U12_RS08545	COG1815	bacterial-type flagellum-dependent cell motility
O6U12_RS08550	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O6U12_RS08555	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O6U12_RS08560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O6U12_RS08565	COG4974	Belongs to the 'phage' integrase family
O6U12_RS08570	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
O6U12_RS08575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O6U12_RS08580	COG0758	DNA mediated transformation
O6U12_RS08585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O6U12_RS08590	COG0045	succinate-CoA ligase (ADP-forming) activity
O6U12_RS08595	COG2257	FlhB HrpN YscU SpaS Family
O6U12_RS08605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O6U12_RS08610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O6U12_RS08615	COG0335	large ribosomal subunit rRNA binding
O6U12_RS08620	COG0336	Belongs to the RNA methyltransferase TrmD family
O6U12_RS08625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O6U12_RS08635	COG1837	Belongs to the UPF0109 family
O6U12_RS08640	COG0228	four-way junction DNA binding
O6U12_RS08645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O6U12_RS08650	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
O6U12_RS08660	COG0552	protein localization to endoplasmic reticulum
O6U12_RS08665	COG1196	nuclear chromosome segregation
O6U12_RS08670	COG0571	ribonuclease III activity
O6U12_RS08680	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS08685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O6U12_RS08690	COG0416	fatty acid biosynthetic process
O6U12_RS08695	COG2050	protein possibly involved in aromatic compounds catabolism
O6U12_RS08695	COG1349	DNA-binding transcription factor activity
O6U12_RS08700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O6U12_RS08705	COG1760	l-serine dehydratase
O6U12_RS08710	COG1760	l-serine dehydratase
O6U12_RS08715	COG1461	Dihydroxyacetone kinase
O6U12_RS08720	COG1302	Protein conserved in bacteria
O6U12_RS08725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O6U12_RS08735	COG1564	THIamine pyrophosphokinase
O6U12_RS08740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O6U12_RS08745	COG1162	GTPase activity
O6U12_RS08750	COG0515	serine threonine protein kinase
O6U12_RS08750	COG2815	serine threonine protein kinase
O6U12_RS08755	COG0631	protein serine/threonine phosphatase activity
O6U12_RS08760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O6U12_RS08765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O6U12_RS08765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O6U12_RS08770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O6U12_RS08775	COG0242	peptide deformylase activity
O6U12_RS08780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O6U12_RS08785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O6U12_RS08790	COG1758	RNA polymerase activity
O6U12_RS08795	COG0194	GDP metabolic process
O6U12_RS08805	COG1561	YicC-like family, N-terminal region
O6U12_RS08810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O6U12_RS08815	COG1293	RNA-binding protein homologous to eukaryotic snRNP
O6U12_RS08820	COG1648	precorrin-2 dehydrogenase activity
O6U12_RS08825	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
O6U12_RS08830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O6U12_RS08835	COG0529	Catalyzes the synthesis of activated sulfate
O6U12_RS08840	COG2046	Belongs to the sulfate adenylyltransferase family
O6U12_RS08845	COG0306	phosphate transporter
O6U12_RS08850	COG0175	sulfate reduction
O6U12_RS08855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O6U12_RS08860	COG0284	orotidine-5'-phosphate decarboxylase activity
O6U12_RS08865	COG0167	dihydroorotate dehydrogenase activity
O6U12_RS08870	COG0543	2 iron, 2 sulfur cluster binding
O6U12_RS08875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O6U12_RS08880	COG0505	Belongs to the CarA family
O6U12_RS08885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O6U12_RS08890	COG0540	Belongs to the ATCase OTCase family
O6U12_RS08895	COG2233	PERMEase
O6U12_RS08900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O6U12_RS08905	COG0564	pseudouridine synthase activity
O6U12_RS08910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O6U12_RS08915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O6U12_RS08920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O6U12_RS08925	COG3599	regulation of cell shape
O6U12_RS08930	COG2302	S4 RNA-binding domain
O6U12_RS08935	COG0762	integral membrane protein
O6U12_RS08940	COG1799	cell septum assembly
O6U12_RS08945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O6U12_RS08950	COG1496	oxidoreductase activity
O6U12_RS08955	COG1873	PFAM PRC-barrel domain
O6U12_RS08960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O6U12_RS08965	COG1119	ATPase activity
O6U12_RS08970	COG1191	sigma factor activity
O6U12_RS08975	COG1191	sigma factor activity
O6U12_RS08985	COG1404	Belongs to the peptidase S8 family
O6U12_RS08985	COG4412	M6 family metalloprotease domain protein
O6U12_RS08990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O6U12_RS08995	COG0849	cell division
O6U12_RS09000	COG3856	small basic protein
O6U12_RS09005	COG3879	Bacterial protein of unknown function (DUF881)
O6U12_RS09010	COG3879	Bacterial protein of unknown function (DUF881)
O6U12_RS09015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O6U12_RS09020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O6U12_RS09025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O6U12_RS09030	COG0772	Belongs to the SEDS family
O6U12_RS09035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O6U12_RS09040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O6U12_RS09045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O6U12_RS09050	COG0768	penicillin binding
O6U12_RS09055	COG0768	penicillin binding
O6U12_RS09060	COG4839	cell division protein FtsL
O6U12_RS09065	COG0275	rRNA processing
O6U12_RS09070	COG2001	Belongs to the MraZ family
O6U12_RS09075	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
O6U12_RS09080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O6U12_RS09085	COG0454	-acetyltransferase
O6U12_RS09100	COG1399	metal-binding, possibly nucleic acid-binding protein
O6U12_RS09110	COG1323	Belongs to the UPF0348 family
O6U12_RS09115	COG3480	Lon protease (S16) C-terminal proteolytic domain
O6U12_RS09120	COG1752	Esterase of the alpha-beta hydrolase superfamily
O6U12_RS09125	COG3314	Sporulation integral membrane protein YlbJ
O6U12_RS09130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O6U12_RS09135	COG0742	ribosomal rna small subunit methyltransferase
O6U12_RS09140	COG4471	UPF0298 protein
O6U12_RS09145	COG3679	Belongs to the UPF0342 family
O6U12_RS09160	COG2340	Cysteine-rich secretory protein family
O6U12_RS09165	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
O6U12_RS09175	COG3336	cytochrome c oxidase
O6U12_RS09180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O6U12_RS09185	COG1845	cytochrome c oxidase, subunit III
O6U12_RS09190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O6U12_RS09195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O6U12_RS09195	COG2010	Cytochrome c
O6U12_RS09200	COG0109	protoheme IX farnesyltransferase activity
O6U12_RS09205	COG1612	heme a metabolic process
O6U12_RS09210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O6U12_RS09215	COG0772	Belongs to the SEDS family
O6U12_RS09220	COG4838	Belongs to the UPF0358 family
O6U12_RS09225	COG2066	Belongs to the glutaminase family
O6U12_RS09230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O6U12_RS09235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O6U12_RS09245	COG4896	Protein conserved in bacteria
O6U12_RS09255	COG1217	gtp-binding protein TYPA
O6U12_RS09275	COG1595	DNA-templated transcription, initiation
O6U12_RS09295	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
O6U12_RS09305	COG0483	inositol monophosphate 1-phosphatase activity
O6U12_RS09315	COG4493	Belongs to the UPF0637 family
O6U12_RS09320	COG4476	Belongs to the UPF0223 family
O6U12_RS09325	COG1982	Orn Lys Arg decarboxylase major
O6U12_RS09340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS09345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O6U12_RS09350	COG0508	dehydrogenase complex catalyzes the overall conversion of
O6U12_RS09355	COG0022	dehydrogenase e1 component
O6U12_RS09360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O6U12_RS09365	COG0497	DNA recombination
O6U12_RS09375	COG0242	peptide deformylase activity
O6U12_RS09380	COG0561	phosphatase activity
O6U12_RS09385	COG5503	Protein of unknown function (DUF1447)
O6U12_RS09390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O6U12_RS09395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O6U12_RS09400	COG0569	domain protein
O6U12_RS09405	COG2105	PFAM AIG2 family protein
O6U12_RS09405	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
O6U12_RS09410	COG3852	Histidine kinase
O6U12_RS09415	COG2002	toxin-antitoxin pair type II binding
O6U12_RS09420	COG1077	Cell shape determining protein MreB Mrl
O6U12_RS09430	COG2309	aminopeptidase activity
O6U12_RS09435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O6U12_RS09440	COG0488	(ABC) transporter
O6U12_RS09450	COG0681	Belongs to the peptidase S26 family
O6U12_RS09455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O6U12_RS09455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_RS09455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O6U12_RS09460	COG1105	Belongs to the carbohydrate kinase PfkB family
O6U12_RS09465	COG1349	DNA-binding transcription factor activity
O6U12_RS09470	COG0577	efflux transmembrane transporter activity
O6U12_RS09475	COG1136	(ABC) transporter
O6U12_RS09480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O6U12_RS09490	COG1132	(ABC) transporter
O6U12_RS09495	COG1132	(ABC) transporter
O6U12_RS09500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O6U12_RS09505	COG0314	molybdopterin synthase activity
O6U12_RS09510	COG1763	Mo-molybdopterin cofactor biosynthetic process
O6U12_RS09515	COG0303	'Molybdopterin
O6U12_RS09520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O6U12_RS09525	COG0746	molybdenum cofactor guanylyltransferase activity
O6U12_RS09545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS09550	COG0450	alkyl hydroperoxide reductase
O6U12_RS09555	COG0668	transmembrane transport
O6U12_RS09565	COG1473	amidohydrolase
O6U12_RS09570	COG2171	N-acyltransferase activity
O6U12_RS09575	COG0716	FMN binding
O6U12_RS09585	COG0716	FMN binding
O6U12_RS09590	COG0583	DNA-binding transcription factor activity
O6U12_RS09595	COG0517	IMP dehydrogenase activity
O6U12_RS09605	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
O6U12_RS09610	COG4703	Protein of unknown function (DUF1797)
O6U12_RS09615	COG2200	EAL domain
O6U12_RS09625	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS09640	COG1408	metallophosphoesterase
O6U12_RS09645	COG1376	ErfK ybiS ycfS ynhG family protein
O6U12_RS09650	COG2814	Major facilitator Superfamily
O6U12_RS09660	COG0784	Response regulator, receiver
O6U12_RS09660	COG0835	chemotaxis
O6U12_RS09670	COG0436	Aminotransferase
O6U12_RS09675	COG4191	Histidine kinase
O6U12_RS09680	COG0768	penicillin binding
O6U12_RS09685	COG2340	Cysteine-rich secretory protein family
O6U12_RS09690	COG3328	transposase activity
O6U12_RS09695	COG2084	Dehydrogenase
O6U12_RS09700	COG0840	transmembrane signaling receptor activity
O6U12_RS09705	COG0456	acetyltransferase
O6U12_RS09710	COG1533	DNA photolyase activity
O6U12_RS09720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O6U12_RS09725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_RS09730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_RS09730	COG2190	(PTS) system
O6U12_RS09730	COG1263	PTS System
O6U12_RS09735	COG3711	transcriptional antiterminator
O6U12_RS09740	COG1609	Transcriptional regulator
O6U12_RS09745	COG0006	proline dipeptidase activity
O6U12_RS09755	COG2217	Heavy metal translocating P-type atpase
O6U12_RS09760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS09765	COG2244	polysaccharide biosynthetic process
O6U12_RS09770	COG3773	Cell wall hydrolase
O6U12_RS09780	COG4873	Protein conserved in bacteria
O6U12_RS09790	COG3858	chitin binding
O6U12_RS09795	COG1388	LysM domain
O6U12_RS09800	COG4641	Protein conserved in bacteria
O6U12_RS09800	COG1388	LysM domain
O6U12_RS09805	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS09810	COG1733	regulation of RNA biosynthetic process
O6U12_RS09815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O6U12_RS09820	COG0602	queuosine metabolic process
O6U12_RS09825	COG0720	synthase
O6U12_RS09830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O6U12_RS09835	COG3949	Membrane
O6U12_RS09840	COG0542	response to heat
O6U12_RS09845	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O6U12_RS09850	COG1360	Flagellar Motor Protein
O6U12_RS09855	COG1846	Transcriptional regulator
O6U12_RS09860	COG3852	Histidine kinase
O6U12_RS09875	COG3339	Conserved Protein
O6U12_RS09880	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
O6U12_RS09885	COG0235	Class ii aldolase
O6U12_RS09890	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
O6U12_RS09895	COG1850	ribulose-bisphosphate carboxylase activity
O6U12_RS09900	COG0436	Aminotransferase
O6U12_RS09905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O6U12_RS09910	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
O6U12_RS09915	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O6U12_RS09925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O6U12_RS09930	COG5002	protein histidine kinase activity
O6U12_RS09935	COG3594	Acyltransferase
O6U12_RS09950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O6U12_RS09955	COG0501	Belongs to the peptidase M48B family
O6U12_RS09975	COG1191	sigma factor activity
O6U12_RS09980	COG0861	Integral membrane protein TerC family
O6U12_RS09985	COG0586	Pfam SNARE associated Golgi protein
O6U12_RS09995	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O6U12_RS10000	COG3285	dna ligase
O6U12_RS10000	COG1793	dna ligase
O6U12_RS10005	COG0463	Glycosyl transferase, family 2
O6U12_RS10015	COG1408	metallophosphoesterase
O6U12_RS10020	COG0726	polysaccharide deacetylase
O6U12_RS10025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O6U12_RS10030	COG1846	Transcriptional regulator
O6U12_RS10045	COG0789	Transcriptional regulator
O6U12_RS10050	COG2239	Acts as a magnesium transporter
O6U12_RS10065	COG3212	peptidase
O6U12_RS10070	COG3212	peptidase
O6U12_RS10075	COG5002	protein histidine kinase activity
O6U12_RS10075	COG3850	Histidine kinase
O6U12_RS10080	COG0745	RESPONSE REGULATOR receiver
O6U12_RS10090	COG4721	ABC-type cobalt transport system, permease component
O6U12_RS10095	COG1122	ATPase activity
O6U12_RS10100	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O6U12_RS10105	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_RS10110	COG1404	Belongs to the peptidase S8 family
O6U12_RS10115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O6U12_RS10125	COG0590	tRNA wobble adenosine to inosine editing
O6U12_RS10135	COG1764	response to oxidative stress
O6U12_RS10140	COG1846	Transcriptional regulator
O6U12_RS10145	COG1764	response to oxidative stress
O6U12_RS10150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O6U12_RS10155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O6U12_RS10160	COG0788	formyltetrahydrofolate deformylase activity
O6U12_RS10165	COG2076	Multidrug Resistance protein
O6U12_RS10170	COG2076	Multidrug Resistance protein
O6U12_RS10175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_RS10180	COG2318	DinB family
O6U12_RS10185	COG2323	membrane
O6U12_RS10195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O6U12_RS10195	COG1017	nitric oxide dioxygenase activity
O6U12_RS10200	COG1607	acyl-coa hydrolase
O6U12_RS10210	COG2706	6-phosphogluconolactonase activity
O6U12_RS10215	COG4608	Belongs to the ABC transporter superfamily
O6U12_RS10220	COG0791	NLP P60 protein
O6U12_RS10225	COG4948	Mandelate Racemase Muconate Lactonizing
O6U12_RS10230	COG1619	proteins homologs of microcin C7 resistance protein MccF
O6U12_RS10235	COG4166	transmembrane transport
O6U12_RS10240	COG0444	Belongs to the ABC transporter superfamily
O6U12_RS10245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O6U12_RS10250	COG0601	transmembrane transport
O6U12_RS10255	COG2362	D-Aminopeptidase
O6U12_RS10260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O6U12_RS10265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O6U12_RS10275	COG0463	Glycosyl transferase, family 2
O6U12_RS10280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O6U12_RS10290	COG0346	lactoylglutathione lyase activity
O6U12_RS10295	COG0531	amino acid
O6U12_RS10300	COG1392	Phosphate transport regulator
O6U12_RS10305	COG0306	phosphate transporter
O6U12_RS10325	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS10325	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS10365	COG3778	Protein conserved in bacteria
O6U12_RS10370	COG3299	homolog of phage Mu protein gp47
O6U12_RS10375	COG3628	GPW Gp25 family protein
O6U12_RS10385	COG4193	domain, Protein
O6U12_RS10390	COG1652	LysM domain
O6U12_RS10395	COG5412	phage tail tape measure protein
O6U12_RS10395	COG3953	SLT domain
O6U12_RS10445	COG4653	Phage capsid family
O6U12_RS10450	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O6U12_RS10455	COG5518	Phage portal protein
O6U12_RS10460	COG1783	phage Terminase large subunit
O6U12_RS10465	COG5484	DNA packaging
O6U12_RS10465	COG3728	DNA packaging
O6U12_RS10470	COG1595	DNA-templated transcription, initiation
O6U12_RS10505	COG1396	sequence-specific DNA binding
O6U12_RS10510	COG2856	Zn peptidase
O6U12_RS10515	COG3546	catalase activity
O6U12_RS10520	COG4195	phage-related replication protein
O6U12_RS10530	COG1388	LysM domain
O6U12_RS10530	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS10530	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS10535	COG2350	Protein conserved in bacteria
O6U12_RS10545	COG0457	Tetratricopeptide repeat
O6U12_RS10550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O6U12_RS10555	COG2318	DinB family
O6U12_RS10560	COG0730	response to heat
O6U12_RS10565	COG2721	sulfolactate sulfo-lyase activity
O6U12_RS10570	COG0246	Mannitol dehydrogenase
O6U12_RS10575	COG1609	Transcriptional regulator
O6U12_RS10580	COG2271	Major facilitator Superfamily
O6U12_RS10585	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS10590	COG1312	Catalyzes the dehydration of D-mannonate
O6U12_RS10595	COG1063	alcohol dehydrogenase
O6U12_RS10600	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
O6U12_RS10605	COG2211	Major facilitator Superfamily
O6U12_RS10610	COG1904	glucuronate isomerase
O6U12_RS10615	COG1252	NADH dehydrogenase
O6U12_RS10625	COG4297	protein containing double-stranded beta helix domain
O6U12_RS10630	COG0697	spore germination
O6U12_RS10635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O6U12_RS10640	COG0390	transport system, permease component
O6U12_RS10645	COG1587	Uroporphyrinogen-III synthase
O6U12_RS10655	COG1819	glycosyl
O6U12_RS10660	COG2124	cytochrome p450
O6U12_RS10680	COG2427	Protein of unknown function (DUF1641)
O6U12_RS10695	COG2205	protein histidine kinase activity
O6U12_RS10700	COG5504	Zn-dependent protease
O6U12_RS10715	COG0726	polysaccharide deacetylase
O6U12_RS10725	COG0109	protoheme IX farnesyltransferase activity
O6U12_RS10740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O6U12_RS10750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_RS10755	COG3328	transposase activity
O6U12_RS10765	COG1482	cell wall glycoprotein biosynthetic process
O6U12_RS10770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_RS10770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O6U12_RS10770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O6U12_RS10775	COG3711	transcriptional antiterminator
O6U12_RS10775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_RS10785	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS10790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O6U12_RS10845	COG5444	nuclease activity
O6U12_RS10870	COG5505	Protein of unknown function (DUF819)
O6U12_RS10875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_RS10880	COG0626	cystathionine gamma-synthase activity
O6U12_RS10885	COG0626	cystathionine gamma-synthase activity
O6U12_RS10890	COG2382	esterase
O6U12_RS10895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O6U12_RS10900	COG2153	protein acetylation
O6U12_RS10910	COG0210	DNA helicase
O6U12_RS10965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O6U12_RS10970	COG0351	phosphomethylpyrimidine kinase
O6U12_RS10975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O6U12_RS10980	COG2022	thiamine diphosphate biosynthetic process
O6U12_RS10985	COG2104	thiamine diphosphate biosynthetic process
O6U12_RS10990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O6U12_RS10995	COG0352	thiamine-phosphate diphosphorylase activity
O6U12_RS11000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O6U12_RS11005	COG0569	domain protein
O6U12_RS11005	COG0475	glutathione-regulated potassium exporter activity
O6U12_RS11010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O6U12_RS11015	COG0564	pseudouridine synthase activity
O6U12_RS11020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O6U12_RS11025	COG2357	RelA SpoT domain protein
O6U12_RS11035	COG4116	CYTH
O6U12_RS11040	COG0741	lytic transglycosylase activity
O6U12_RS11045	COG2346	COG2346, Truncated hemoglobins
O6U12_RS11050	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O6U12_RS11060	COG1164	Oligoendopeptidase f
O6U12_RS11065	COG4469	Competence protein
O6U12_RS11075	COG4862	establishment of competence for transformation
O6U12_RS11085	COG0861	Integral membrane protein TerC family
O6U12_RS11090	COG1393	Belongs to the ArsC family
O6U12_RS11095	COG0456	acetyltransferase
O6U12_RS11100	COG2814	Major facilitator Superfamily
O6U12_RS11105	COG4608	Belongs to the ABC transporter superfamily
O6U12_RS11110	COG0444	Belongs to the ABC transporter superfamily
O6U12_RS11115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O6U12_RS11120	COG0601	transmembrane transport
O6U12_RS11125	COG4166	transmembrane transport
O6U12_RS11130	COG0180	Tryptophanyl-tRNA synthetase
O6U12_RS11140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O6U12_RS11145	COG0601	transmembrane transport
O6U12_RS11155	COG4608	Belongs to the ABC transporter superfamily
O6U12_RS11160	COG0444	Belongs to the ABC transporter superfamily
O6U12_RS11165	COG5504	Zn-dependent protease
O6U12_RS11170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O6U12_RS11175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_RS11190	COG1744	ABC transporter substrate-binding protein PnrA-like
O6U12_RS11200	COG2267	carboxylic ester hydrolase activity
O6U12_RS11215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O6U12_RS11220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O6U12_RS11225	COG0505	Belongs to the CarA family
O6U12_RS11230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O6U12_RS11240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O6U12_RS11245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O6U12_RS11250	COG2271	Major facilitator Superfamily
O6U12_RS11255	COG0277	FAD linked oxidase domain protein
O6U12_RS11265	COG2151	metal-sulfur cluster biosynthetic enzyme
O6U12_RS11270	COG1073	alpha beta
O6U12_RS11275	COG0561	phosphatase activity
O6U12_RS11295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_RS11300	COG1307	EDD domain protein, DegV family
O6U12_RS11305	COG3227	Zinc metalloprotease (Elastase)
O6U12_RS11320	COG1695	Transcriptional regulator
O6U12_RS11345	COG1666	GTP binding
O6U12_RS11350	COG0646	methionine synthase
O6U12_RS11350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
O6U12_RS11355	COG2153	protein acetylation
O6U12_RS11360	COG0454	-acetyltransferase
O6U12_RS11365	COG2814	Major facilitator Superfamily
O6U12_RS11370	COG2323	membrane
O6U12_RS11375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_RS11385	COG2323	membrane
O6U12_RS11400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_RS11455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_RS11460	COG1809	phosphosulfolactate synthase activity
O6U12_RS11465	COG2045	Belongs to the ComB family
O6U12_RS11480	COG0529	Catalyzes the synthesis of activated sulfate
O6U12_RS11485	COG2267	carboxylic ester hydrolase activity
O6U12_RS11490	COG1357	PFAM Pentapeptide repeats (8 copies)
O6U12_RS11495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_RS11500	COG1279	arginine transmembrane transporter activity
O6U12_RS11505	COG2318	DinB family
O6U12_RS11510	COG0673	inositol 2-dehydrogenase activity
O6U12_RS11515	COG1609	Transcriptional regulator
O6U12_RS11520	COG1917	Cupin 2, conserved barrel domain protein
O6U12_RS11520	COG2207	Transcriptional regulator
O6U12_RS11525	COG0534	Mate efflux family protein
O6U12_RS11535	COG0367	asparagine synthase
O6U12_RS11545	COG1404	Belongs to the peptidase S8 family
O6U12_RS11555	COG0179	Fumarylacetoacetate (FAA) hydrolase
O6U12_RS11560	COG5337	Spore coat protein CotH
O6U12_RS11600	COG1403	HNH endonuclease
O6U12_RS11605	COG0419	ATPase involved in DNA repair
O6U12_RS11610	COG0420	3'-5' exonuclease activity
O6U12_RS11615	COG1074	ATP-dependent DNA helicase activity
O6U12_RS11620	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
O6U12_RS11625	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
O6U12_RS11635	COG4533	DNA binding
O6U12_RS11640	COG2814	Major facilitator Superfamily
O6U12_RS11640	COG0477	Major facilitator Superfamily
O6U12_RS11645	COG3180	Ammonia monooxygenase
O6U12_RS11650	COG1609	Transcriptional regulator
O6U12_RS11660	COG0561	phosphatase activity
O6U12_RS11665	COG0673	inositol 2-dehydrogenase activity
O6U12_RS11670	COG0738	Major facilitator superfamily
O6U12_RS11675	COG1846	Transcriptional regulator
O6U12_RS11680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O6U12_RS11685	COG0681	Belongs to the peptidase S26 family
O6U12_RS11690	COG0398	Pfam SNARE associated Golgi protein
O6U12_RS11705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_RS11715	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS11720	COG4903	ComK protein
O6U12_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS11740	COG0840	transmembrane signaling receptor activity
O6U12_RS11745	COG1268	BioY protein
O6U12_RS11750	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_RS11755	COG0183	Belongs to the thiolase family
O6U12_RS11760	COG0406	alpha-ribazole phosphatase activity
O6U12_RS11765	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
O6U12_RS11770	COG0604	alcohol dehydrogenase
O6U12_RS11775	COG0456	acetyltransferase
O6U12_RS11780	COG1404	Belongs to the peptidase S8 family
O6U12_RS11785	COG0501	Belongs to the peptidase M48B family
O6U12_RS11795	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_RS11800	COG0702	epimerase
O6U12_RS11805	COG0095	Lipoate-protein ligase
O6U12_RS11810	COG1234	tRNA 3'-trailer cleavage
O6U12_RS11820	COG1301	dicarboxylic acid transport
O6U12_RS11825	COG4405	Protein conserved in bacteria
O6U12_RS11830	COG1363	Peptidase, m42
O6U12_RS11840	COG4377	Putative membrane peptidase family (DUF2324)
O6U12_RS11845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_RS11850	COG1511	domain protein
O6U12_RS11855	COG1309	transcriptional regulator
O6U12_RS11860	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
O6U12_RS11865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O6U12_RS11870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O6U12_RS11875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O6U12_RS11880	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_RS11890	COG3069	C4-dicarboxylate transmembrane transporter activity
O6U12_RS11895	COG1473	amidohydrolase
O6U12_RS11905	COG4473	ABC transporter
O6U12_RS11910	COG1131	(ABC) transporter
O6U12_RS11915	COG0537	adenosine 5'-monophosphoramidase activity
O6U12_RS11920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O6U12_RS11935	COG4980	gas vesicle protein
O6U12_RS11940	COG1846	Transcriptional regulator
O6U12_RS11970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O6U12_RS11980	COG3481	metal-dependent phosphohydrolase, HD sub domain
O6U12_RS11985	COG4717	serine-type aminopeptidase activity
O6U12_RS11990	COG0420	3'-5' exonuclease activity
O6U12_RS11995	COG1668	transmembrane transport
O6U12_RS12000	COG4152	abc transporter atp-binding protein
O6U12_RS12010	COG1024	Enoyl-CoA hydratase
O6U12_RS12020	COG0490	domain, Protein
O6U12_RS12025	COG0475	glutathione-regulated potassium exporter activity
O6U12_RS12030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O6U12_RS12035	COG0561	phosphatase activity
O6U12_RS12040	COG4335	DNA alkylation repair
O6U12_RS12045	COG3679	Belongs to the UPF0342 family
O6U12_RS12050	COG4399	Belongs to the UPF0754 family
O6U12_RS12055	COG0189	ligase activity
O6U12_RS12060	COG0189	ligase activity
O6U12_RS12085	COG1132	(ABC) transporter
O6U12_RS12090	COG1132	(ABC) transporter
O6U12_RS12100	COG0589	response to stress
O6U12_RS12105	COG1757	Na H antiporter
O6U12_RS12110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O6U12_RS12115	COG0726	polysaccharide deacetylase
O6U12_RS12120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O6U12_RS12125	COG0668	transmembrane transport
O6U12_RS12135	COG0584	glycerophosphoryl diester phosphodiesterase
O6U12_RS12140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O6U12_RS12145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O6U12_RS12150	COG1253	flavin adenine dinucleotide binding
O6U12_RS12155	COG0436	Aminotransferase
O6U12_RS12160	COG0789	Transcriptional regulator
O6U12_RS12165	COG1253	flavin adenine dinucleotide binding
O6U12_RS12170	COG0204	Acyl-transferase
O6U12_RS12175	COG0667	Aldo Keto reductase
O6U12_RS12180	COG1595	DNA-templated transcription, initiation
O6U12_RS12195	COG0456	acetyltransferase
O6U12_RS12200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_RS12205	COG0733	neurotransmitter:sodium symporter activity
O6U12_RS12210	COG0531	amino acid
O6U12_RS12215	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS12220	COG0372	Belongs to the citrate synthase family
O6U12_RS12230	COG0791	NLP P60 protein
O6U12_RS12230	COG1388	LysM domain
O6U12_RS12235	COG1785	Belongs to the alkaline phosphatase family
O6U12_RS12240	COG2719	SpoVR family
O6U12_RS12250	COG1959	2 iron, 2 sulfur cluster binding
O6U12_RS12255	COG0791	NLP P60 protein
O6U12_RS12255	COG1388	LysM domain
O6U12_RS12270	COG0431	NADPH-dependent FMN reductase
O6U12_RS12275	COG2197	response regulator
O6U12_RS12280	COG2203	Gaf domain
O6U12_RS12280	COG4585	Histidine kinase
O6U12_RS12285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O6U12_RS12290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O6U12_RS12295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O6U12_RS12300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O6U12_RS12305	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
O6U12_RS12310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O6U12_RS12315	COG3153	acetyltransferase
O6U12_RS12315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O6U12_RS12320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O6U12_RS12325	COG0517	IMP dehydrogenase activity
O6U12_RS12335	COG0564	pseudouridine synthase activity
O6U12_RS12340	COG3764	Sortase (surface protein transpeptidase)
O6U12_RS12345	COG0737	Belongs to the 5'-nucleotidase family
O6U12_RS12345	COG1525	nuclease
O6U12_RS12345	COG4085	toxin activity
O6U12_RS12365	COG1823	symporter activity
O6U12_RS12375	COG1464	Belongs to the NlpA lipoprotein family
O6U12_RS12380	COG1278	Cold shock
O6U12_RS12385	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O6U12_RS12390	COG1131	(ABC) transporter
O6U12_RS12395	COG1131	(ABC) transporter
O6U12_RS12400	COG1725	Transcriptional regulator
O6U12_RS12420	COG0655	NAD(P)H dehydrogenase (quinone) activity
O6U12_RS12425	COG2814	Major facilitator Superfamily
O6U12_RS12430	COG1566	PFAM secretion protein HlyD family protein
O6U12_RS12435	COG1846	Transcriptional regulator
O6U12_RS12440	COG2718	Belongs to the UPF0229 family
O6U12_RS12445	COG2766	serine protein kinase
O6U12_RS12450	COG1664	Polymer-forming cytoskeletal
O6U12_RS12455	COG0789	Transcriptional regulator
O6U12_RS12465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O6U12_RS12475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O6U12_RS12480	COG3382	B3 4 domain protein
O6U12_RS12490	COG1476	TRANSCRIPTIONal
O6U12_RS12500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O6U12_RS12510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_RS12515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O6U12_RS12520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O6U12_RS12525	COG1116	anion transmembrane transporter activity
O6U12_RS12530	COG0753	catalase activity
O6U12_RS12540	COG0277	FAD linked oxidase domain protein
O6U12_RS12545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O6U12_RS12550	COG3340	Belongs to the peptidase S51 family
O6U12_RS12555	COG5577	PFAM Coat F domain
O6U12_RS12565	COG4326	sporulation control protein
O6U12_RS12680	COG0735	belongs to the Fur family
O6U12_RS12685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O6U12_RS12690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O6U12_RS12695	COG4129	membrane
O6U12_RS12700	COG1132	(ABC) transporter
O6U12_RS12705	COG3557	Belongs to the UPF0374 family
O6U12_RS12720	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS12730	COG1194	a g-specific adenine glycosylase
O6U12_RS12735	COG1988	membrane-bound metal-dependent
O6U12_RS12740	COG4485	Bacterial membrane protein, YfhO
O6U12_RS12745	COG0463	Glycosyl transferase, family 2
O6U12_RS12750	COG0596	Alpha beta hydrolase
O6U12_RS12755	COG5658	integral membrane protein
O6U12_RS12760	COG3103	Sh3 type 3 domain protein
O6U12_RS12780	COG2814	Major facilitator Superfamily
O6U12_RS12790	COG2137	regulation of response to DNA damage stimulus
O6U12_RS12815	COG0778	Nitroreductase
O6U12_RS12820	COG0384	phenazine biosynthesis protein PhzF
O6U12_RS12825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_RS12830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_RS12835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_RS12840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O6U12_RS12840	COG0392	lysyltransferase activity
O6U12_RS12845	COG1846	Transcriptional regulator
O6U12_RS12850	COG2814	Major facilitator Superfamily
O6U12_RS12855	COG2318	DinB family
O6U12_RS12860	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
O6U12_RS12870	COG1695	Transcriptional regulator
O6U12_RS12880	COG0842	Transport permease protein
O6U12_RS12885	COG0842	Transport permease protein
O6U12_RS12885	COG1511	domain protein
O6U12_RS12890	COG1131	(ABC) transporter
O6U12_RS12895	COG2197	response regulator
O6U12_RS12900	COG4585	Histidine kinase
O6U12_RS12905	COG0673	inositol 2-dehydrogenase activity
O6U12_RS12910	COG1082	Xylose isomerase domain protein TIM barrel
O6U12_RS12915	COG2814	Major facilitator Superfamily
O6U12_RS12920	COG1917	Cupin 2, conserved barrel domain protein
O6U12_RS12920	COG4977	sequence-specific DNA binding
O6U12_RS12925	COG2514	catechol 2,3-dioxygenase activity
O6U12_RS12930	COG2259	Doxx family
O6U12_RS12935	COG1132	(ABC) transporter
O6U12_RS12940	COG1132	(ABC) transporter
O6U12_RS12945	COG1263	PTS System
O6U12_RS12945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_RS12950	COG1737	Transcriptional regulator
O6U12_RS12955	COG1486	melibiose metabolic process
O6U12_RS12960	COG4842	Belongs to the WXG100 family
O6U12_RS12980	COG1742	UPF0060 membrane protein
O6U12_RS12990	COG3284	Transcriptional regulator
O6U12_RS12995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O6U12_RS13000	COG0508	dehydrogenase complex catalyzes the overall conversion of
O6U12_RS13005	COG0022	dehydrogenase e1 component
O6U12_RS13010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O6U12_RS13020	COG4637	Psort location Cytoplasmic, score
O6U12_RS13025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O6U12_RS13035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O6U12_RS13040	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O6U12_RS13045	COG0598	Magnesium transport protein CorA
O6U12_RS13050	COG2084	Dehydrogenase
O6U12_RS13055	COG0726	polysaccharide deacetylase
O6U12_RS13065	COG0535	radical SAM domain protein
O6U12_RS13070	COG0668	transmembrane transport
O6U12_RS13085	COG0387	Pfam Sodium calcium exchanger
O6U12_RS13090	COG0477	Major facilitator Superfamily
O6U12_RS13095	COG1295	ribonuclease BN
O6U12_RS13100	COG4980	gas vesicle protein
O6U12_RS13105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O6U12_RS13110	COG4840	Belongs to the UPF0435 family
O6U12_RS13115	COG2814	Major facilitator Superfamily
O6U12_RS13120	COG0693	protein deglycase activity
O6U12_RS13125	COG0737	Belongs to the 5'-nucleotidase family
O6U12_RS13130	COG0778	Nitroreductase
O6U12_RS13135	COG2188	Transcriptional regulator
O6U12_RS13140	COG0366	Alpha amylase catalytic
O6U12_RS13145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_RS13145	COG1263	PTS System
O6U12_RS13170	COG1368	sulfuric ester hydrolase activity
O6U12_RS13175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_RS13175	COG1263	PTS System
O6U12_RS13180	COG0024	Methionine aminopeptidase
O6U12_RS13205	COG1254	Belongs to the acylphosphatase family
O6U12_RS13210	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
O6U12_RS13215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_RS13220	COG2851	Citrate transporter
O6U12_RS13225	COG3181	Tripartite tricarboxylate transporter family receptor
O6U12_RS13230	COG4565	transcriptional regulatory protein
O6U12_RS13235	COG3290	protein histidine kinase activity
O6U12_RS13240	COG0471	metal ion transport
O6U12_RS13245	COG3866	Pectate lyase
O6U12_RS13255	COG0513	Belongs to the DEAD box helicase family
O6U12_RS13260	COG0488	(ABC) transporter
O6U12_RS13285	COG2814	Major facilitator Superfamily
O6U12_RS13290	COG0789	Transcriptional regulator
O6U12_RS13300	COG0488	(ABC) transporter
O6U12_RS13310	COG0840	transmembrane signaling receptor activity
O6U12_RS13315	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS13320	COG0531	amino acid
O6U12_RS13325	COG1011	Hydrolase
O6U12_RS13330	COG2223	nitrite transmembrane transporter activity
O6U12_RS13335	COG1442	glycosyl transferase family 8
O6U12_RS13340	COG1216	Glycosyl transferase, family 2
O6U12_RS13345	COG1442	glycosyl transferase family 8
O6U12_RS13350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O6U12_RS13355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O6U12_RS13360	COG1368	sulfuric ester hydrolase activity
O6U12_RS13365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O6U12_RS13365	COG2124	cytochrome p450
O6U12_RS13380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O6U12_RS13385	COG1846	Transcriptional regulator
O6U12_RS13390	COG0697	spore germination
O6U12_RS13395	COG0670	Belongs to the BI1 family
O6U12_RS13400	COG5583	Uncharacterized small protein (DUF2292)
O6U12_RS13420	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_RS13430	COG2323	membrane
O6U12_RS13435	COG1486	melibiose metabolic process
O6U12_RS13440	COG0395	ABC-type sugar transport system, permease component
O6U12_RS13445	COG4209	transmembrane transport
O6U12_RS13450	COG1653	transport
O6U12_RS13460	COG1874	Beta-galactosidase
O6U12_RS13465	COG2755	lipolytic protein G-D-S-L family
O6U12_RS13470	COG3401	FG-GAP repeat protein
O6U12_RS13480	COG5578	integral membrane protein
O6U12_RS13490	COG2755	lipolytic protein G-D-S-L family
O6U12_RS13500	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
O6U12_RS13505	COG0395	ABC-type sugar transport system, permease component
O6U12_RS13510	COG1175	transmembrane transport
O6U12_RS13515	COG1653	transport
O6U12_RS13520	COG2207	Transcriptional regulator
O6U12_RS13520	COG4753	response regulator
O6U12_RS13525	COG2972	Histidine kinase
O6U12_RS13530	COG5578	integral membrane protein
O6U12_RS13540	COG0454	-acetyltransferase
O6U12_RS13545	COG3546	catalase activity
O6U12_RS13560	COG1309	transcriptional regulator
O6U12_RS13570	COG0217	transcriptional regulatory protein
O6U12_RS13580	COG0457	Tetratricopeptide repeat
O6U12_RS13590	COG5444	nuclease activity
O6U12_RS13610	COG0457	Tetratricopeptide repeat
O6U12_RS13620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O6U12_RS13625	COG1597	lipid kinase activity
O6U12_RS13630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O6U12_RS13640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O6U12_RS13645	COG0154	amidase activity
O6U12_RS13650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O6U12_RS13655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_RS13660	COG1285	pathogenesis
O6U12_RS13665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_RS13670	COG4851	CamS sex pheromone cAM373 precursor
O6U12_RS13675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O6U12_RS13680	COG0210	DNA helicase
O6U12_RS13685	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
O6U12_RS13695	COG4496	protein, YerC YecD
O6U12_RS13700	COG1470	cell adhesion involved in biofilm formation
O6U12_RS13705	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O6U12_RS13715	COG0531	amino acid
O6U12_RS13720	COG1522	sequence-specific DNA binding
O6U12_RS13725	COG0151	Belongs to the GarS family
O6U12_RS13730	COG0138	bifunctional purine biosynthesis protein purh
O6U12_RS13735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O6U12_RS13740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O6U12_RS13745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O6U12_RS13750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O6U12_RS13755	COG0047	phosphoribosylformylglycinamidine synthase activity
O6U12_RS13760	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O6U12_RS13765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O6U12_RS13770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O6U12_RS13775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O6U12_RS13780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O6U12_RS13790	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
O6U12_RS13805	COG3064	Membrane
O6U12_RS13810	COG2252	PERMEase
O6U12_RS13815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O6U12_RS13815	COG0519	Catalyzes the synthesis of GMP from XMP
O6U12_RS13820	COG1305	Transglutaminase-like
O6U12_RS13825	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
O6U12_RS13830	COG0714	Associated with various cellular activities
O6U12_RS13835	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O6U12_RS13845	COG1113	amino acid transport
O6U12_RS13850	COG2132	Multicopper oxidase
O6U12_RS13860	COG2267	carboxylic ester hydrolase activity
O6U12_RS13880	COG0823	Involved in the tonB-independent uptake of proteins
O6U12_RS13885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O6U12_RS13890	COG1063	alcohol dehydrogenase
O6U12_RS13895	COG2814	Major facilitator Superfamily
O6U12_RS13905	COG4260	virion core protein, lumpy skin disease virus
O6U12_RS13910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
O6U12_RS13915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O6U12_RS13920	COG1842	Phage shock protein A
O6U12_RS13925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O6U12_RS13930	COG2211	Major facilitator Superfamily
O6U12_RS13935	COG1063	alcohol dehydrogenase
O6U12_RS13940	COG0457	Tetratricopeptide repeat
O6U12_RS13950	COG3328	transposase activity
O6U12_RS13980	COG0459	protein refolding
O6U12_RS13990	COG1266	CAAX protease self-immunity
O6U12_RS14000	COG0805	protein transport
O6U12_RS14005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O6U12_RS14010	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O6U12_RS14015	COG0315	cyclic pyranopterin monophosphate synthase activity
O6U12_RS14020	COG0488	(ABC) transporter
O6U12_RS14025	COG3328	transposase activity
O6U12_RS14030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O6U12_RS14035	COG0456	acetyltransferase
O6U12_RS14040	COG1214	PFAM Peptidase M22, glycoprotease
O6U12_RS14045	COG0802	atpase or kinase
O6U12_RS14050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O6U12_RS14095	COG4124	Belongs to the glycosyl hydrolase 26 family
O6U12_RS14100	COG1482	cell wall glycoprotein biosynthetic process
O6U12_RS14105	COG1940	carbohydrate kinase activity
O6U12_RS14110	COG2188	Transcriptional regulator
O6U12_RS14115	COG2723	6-phospho-beta-galactosidase activity
O6U12_RS14120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O6U12_RS14125	COG1447	Phosphotransferase system cellobiose-specific component IIA
O6U12_RS14130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O6U12_RS14135	COG2814	Major facilitator Superfamily
O6U12_RS14140	COG1388	LysM domain
O6U12_RS14145	COG1078	dGTPase activity
O6U12_RS14150	COG0454	-acetyltransferase
O6U12_RS14160	COG5646	InterPro IPR014922
O6U12_RS14165	COG1785	Belongs to the alkaline phosphatase family
O6U12_RS14175	COG1819	glycosyl
O6U12_RS14180	COG1388	LysM domain
O6U12_RS14180	COG3858	chitin binding
O6U12_RS14185	COG1802	Transcriptional regulator
O6U12_RS14190	COG0730	response to heat
O6U12_RS14195	COG2814	Major facilitator Superfamily
O6U12_RS14200	COG1846	Transcriptional regulator
O6U12_RS14205	COG0778	Nitroreductase
O6U12_RS14210	COG2409	Drug exporters of the RND superfamily
O6U12_RS14210	COG1033	growth of symbiont in host cell
O6U12_RS14215	COG1846	Transcriptional regulator
O6U12_RS14220	COG2318	DinB family
O6U12_RS14225	COG1113	amino acid transport
O6U12_RS14240	COG0456	acetyltransferase
O6U12_RS14250	COG1309	transcriptional regulator
O6U12_RS14265	COG0071	Belongs to the small heat shock protein (HSP20) family
O6U12_RS14270	COG2323	membrane
O6U12_RS14295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS14300	COG2259	Doxx family
O6U12_RS14305	COG0346	lactoylglutathione lyase activity
O6U12_RS14310	COG0778	Nitroreductase
O6U12_RS14315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O6U12_RS14330	COG0457	Tetratricopeptide repeat
O6U12_RS14340	COG0789	Transcriptional regulator
O6U12_RS14340	COG4978	Transcriptional regulator
O6U12_RS14345	COG1811	Na channel or pump
O6U12_RS14350	COG2409	Drug exporters of the RND superfamily
O6U12_RS14355	COG2197	response regulator
O6U12_RS14360	COG4585	Histidine kinase
O6U12_RS14375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O6U12_RS14380	COG0640	Transcriptional regulator
O6U12_RS14385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O6U12_RS14390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_RS14395	COG0697	spore germination
O6U12_RS14405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O6U12_RS14410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O6U12_RS14415	COG0640	Transcriptional regulator
O6U12_RS14420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_RS14425	COG1733	regulation of RNA biosynthetic process
O6U12_RS14430	COG3545	Serine hydrolase
O6U12_RS14435	COG2030	dehydratase
O6U12_RS14440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_RS14445	COG0697	spore germination
O6U12_RS14450	COG1309	transcriptional regulator
O6U12_RS14455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_RS14465	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
O6U12_RS14475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_RS14480	COG3708	Transcriptional regulator
O6U12_RS14480	COG2207	Transcriptional regulator
O6U12_RS14485	COG0697	spore germination
O6U12_RS14490	COG2207	Transcriptional regulator
O6U12_RS14490	COG1917	Cupin 2, conserved barrel domain protein
O6U12_RS14495	COG0697	spore germination
O6U12_RS14500	COG1329	Transcriptional regulator
O6U12_RS14505	COG1278	Cold shock
O6U12_RS14510	COG3239	Fatty acid desaturase
O6U12_RS14520	COG1476	TRANSCRIPTIONal
O6U12_RS14530	COG3328	transposase activity
O6U12_RS14540	COG5444	nuclease activity
O6U12_RS14550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_RS14590	COG3091	SprT-like family
O6U12_RS14600	COG2183	response to ionizing radiation
O6U12_RS14605	COG2208	phosphoserine phosphatase activity
O6U12_RS14610	COG1191	sigma factor activity
O6U12_RS14615	COG2172	sigma factor antagonist activity
O6U12_RS14620	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_RS14625	COG2208	phosphoserine phosphatase activity
O6U12_RS14630	COG2172	sigma factor antagonist activity
O6U12_RS14635	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_RS14640	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_RS14645	COG2337	Toxic component of a toxin-antitoxin (TA) module
O6U12_RS14650	COG0864	Transcriptional regulator
O6U12_RS14655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O6U12_RS14660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O6U12_RS14665	COG0736	holo-[acyl-carrier-protein] synthase activity
O6U12_RS14670	COG0705	Rhomboid family
O6U12_RS14675	COG3428	Bacterial PH domain
O6U12_RS14680	COG3402	PFAM membrane-flanked domain
O6U12_RS14685	COG0513	Belongs to the DEAD box helicase family
O6U12_RS14690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O6U12_RS14695	COG1181	Belongs to the D-alanine--D-alanine ligase family
O6U12_RS14700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS14705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O6U12_RS14725	COG1960	acyl-CoA dehydrogenase activity
O6U12_RS14735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O6U12_RS14740	COG1131	(ABC) transporter
O6U12_RS14750	COG0628	permease
O6U12_RS14755	COG1301	dicarboxylic acid transport
O6U12_RS14760	COG4565	transcriptional regulatory protein
O6U12_RS14765	COG3290	protein histidine kinase activity
O6U12_RS14770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O6U12_RS14775	COG3546	catalase activity
O6U12_RS14780	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_RS14785	COG0662	Cupin 2, conserved barrel domain protein
O6U12_RS14790	COG3729	General stress protein
O6U12_RS14795	COG2217	Heavy metal translocating P-type atpase
O6U12_RS14800	COG4876	unkown
O6U12_RS14805	COG2261	transglycosylase associated protein
O6U12_RS14810	COG1914	H( )-stimulated, divalent metal cation uptake system
O6U12_RS14830	COG0494	nUDIX hydrolase
O6U12_RS14835	COG0531	amino acid
O6U12_RS14845	COG1215	transferase activity, transferring glycosyl groups
O6U12_RS14860	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
O6U12_RS14865	COG0551	DNA topoisomerase type I activity
O6U12_RS14865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O6U12_RS14870	COG1522	sequence-specific DNA binding
O6U12_RS14875	COG2814	Major facilitator Superfamily
O6U12_RS14885	COG3871	stress protein (general stress protein 26)
O6U12_RS14890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_RS14895	COG1917	Cupin 2, conserved barrel domain protein
O6U12_RS14900	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS14905	COG2226	methyltransferase
O6U12_RS14910	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_RS14915	COG3711	transcriptional antiterminator
O6U12_RS14920	COG4989	oxidoreductase activity
O6U12_RS14925	COG0768	penicillin binding
O6U12_RS14930	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_RS14940	COG2755	lipolytic protein G-D-S-L family
O6U12_RS14945	COG1414	Transcriptional regulator
O6U12_RS14950	COG1984	allophanate hydrolase subunit 2
O6U12_RS14955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O6U12_RS14960	COG4336	lyase activity
O6U12_RS14965	COG1914	H( )-stimulated, divalent metal cation uptake system
O6U12_RS14970	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O6U12_RS14975	COG0561	phosphatase activity
O6U12_RS14985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O6U12_RS14990	COG0412	Dienelactone hydrolase
O6U12_RS14995	COG0681	Belongs to the peptidase S26 family
O6U12_RS15000	COG0473	3-isopropylmalate dehydrogenase activity
O6U12_RS15005	COG0246	Mannitol dehydrogenase
O6U12_RS15010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_RS15015	COG2213	PTS system mannitol-specific
O6U12_RS15025	COG1349	DNA-binding transcription factor activity
O6U12_RS15030	COG1276	copper resistance
O6U12_RS15030	COG2372	response to copper ion
O6U12_RS15035	COG4549	nuclear export factor GLE1
O6U12_RS15040	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS15045	COG4975	Glucose uptake
O6U12_RS15050	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS15055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O6U12_RS15060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_RS15065	COG0640	Transcriptional regulator
O6U12_RS15070	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O6U12_RS15075	COG0778	Nitroreductase
O6U12_RS15080	COG1309	transcriptional regulator
O6U12_RS15085	COG2814	Major facilitator Superfamily
O6U12_RS15090	COG4607	ABC-type enterochelin transport system periplasmic component
O6U12_RS15095	COG4604	ABC transporter, ATP-binding protein
O6U12_RS15100	COG4605	iron ion homeostasis
O6U12_RS15105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_RS15110	COG0527	aspartate kinase activity
O6U12_RS15130	COG0457	Tetratricopeptide repeat
O6U12_RS15135	COG5002	protein histidine kinase activity
O6U12_RS15135	COG3850	Histidine kinase
O6U12_RS15140	COG0745	RESPONSE REGULATOR receiver
O6U12_RS15145	COG0577	efflux transmembrane transporter activity
O6U12_RS15150	COG1136	(ABC) transporter
O6U12_RS15155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O6U12_RS15165	COG0697	spore germination
O6U12_RS15175	COG5434	Belongs to the glycosyl hydrolase 28 family
O6U12_RS15180	COG3104	oligopeptide transport
O6U12_RS15185	COG0596	Alpha beta hydrolase
O6U12_RS15200	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O6U12_RS15205	COG0163	prenyltransferase activity
O6U12_RS15210	COG0583	DNA-binding transcription factor activity
O6U12_RS15215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_RS15220	COG0765	amino acid transport
O6U12_RS15225	COG1126	abc transporter atp-binding protein
O6U12_RS15230	COG2364	Membrane
O6U12_RS15240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_RS15245	COG0697	spore germination
O6U12_RS15255	COG2814	Major facilitator Superfamily
O6U12_RS15260	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
O6U12_RS15265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_RS15270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_RS15290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_RS15295	COG1733	regulation of RNA biosynthetic process
O6U12_RS15300	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
O6U12_RS15305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O6U12_RS15310	COG0840	transmembrane signaling receptor activity
O6U12_RS15310	COG3290	protein histidine kinase activity
O6U12_RS15315	COG3209	COG3209 Rhs family protein
O6U12_RS15325	COG2723	6-phospho-beta-galactosidase activity
O6U12_RS15330	COG3842	ATPase activity
O6U12_RS15340	COG1846	Transcriptional regulator
O6U12_RS15350	COG1714	RDD family
O6U12_RS15360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_RS15365	COG0765	amino acid transport
O6U12_RS15370	COG0523	cobalamin synthesis protein
O6U12_RS15385	COG1376	ErfK ybiS ycfS ynhG family protein
O6U12_RS15390	COG1469	GTP cyclohydrolase I activity
O6U12_RS15395	COG2223	nitrite transmembrane transporter activity
O6U12_RS15400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O6U12_RS15405	COG0243	molybdopterin cofactor binding
O6U12_RS15410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O6U12_RS15415	COG2146	nitrite reductase [NAD(P)H] activity
O6U12_RS15420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O6U12_RS15420	COG1587	Uroporphyrinogen-III synthase
O6U12_RS15425	COG0492	ferredoxin-NADP+ reductase activity
O6U12_RS15430	COG2267	carboxylic ester hydrolase activity
O6U12_RS15435	COG0701	Predicted permease
O6U12_RS15440	COG3689	TIGRFAM TIGR03943 family protein
O6U12_RS15445	COG2508	Transcriptional regulator
O6U12_RS15450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_RS15455	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS15460	COG0506	proline dehydrogenase activity
O6U12_RS15465	COG3541	Predicted nucleotidyltransferase
O6U12_RS15470	COG3458	cephalosporin-C deacetylase activity
O6U12_RS15475	COG0583	DNA-binding transcription factor activity
O6U12_RS15480	COG2226	methyltransferase
O6U12_RS15485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O6U12_RS15495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O6U12_RS15500	COG3665	Urea carboxylase-associated protein
O6U12_RS15510	COG3403	YqcI/YcgG family
O6U12_RS15520	COG1620	l-lactate permease
O6U12_RS15525	COG0039	L-malate dehydrogenase activity
O6U12_RS15545	COG1288	antiporter activity
O6U12_RS15550	COG1473	amidohydrolase
O6U12_RS15555	COG2113	Glycine betaine
O6U12_RS15560	COG4176	ABC-type proline glycine betaine transport system permease component
O6U12_RS15565	COG4175	Glycine betaine
O6U12_RS15565	COG0517	IMP dehydrogenase activity
O6U12_RS15570	COG0640	Transcriptional regulator
O6U12_RS15575	COG2814	Major facilitator Superfamily
O6U12_RS15580	COG0477	Major facilitator Superfamily
O6U12_RS15585	COG3853	Toxic anion resistance protein (TelA)
O6U12_RS15595	COG0861	Integral membrane protein TerC family
O6U12_RS15600	COG2310	stress, protein
O6U12_RS15605	COG2310	stress, protein
O6U12_RS15610	COG2310	stress, protein
O6U12_RS15615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_RS15620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O6U12_RS15625	COG1121	(ABC) transporter
O6U12_RS15630	COG0803	Belongs to the bacterial solute-binding protein 9 family
O6U12_RS15640	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS15650	COG1876	peptidase activity
O6U12_RS15655	COG1595	DNA-templated transcription, initiation
O6U12_RS15660	COG1595	DNA-templated transcription, initiation
O6U12_RS15675	COG0667	Aldo Keto reductase
O6U12_RS15680	COG1668	transmembrane transport
O6U12_RS15685	COG4555	ABC transporter
O6U12_RS15690	COG3279	Response regulator of the LytR AlgR family
O6U12_RS15700	COG3012	SEC-C Motif Domain Protein
O6U12_RS15700	COG1405	negative regulation of cell septum assembly
O6U12_RS15705	COG1714	RDD family
O6U12_RS15710	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O6U12_RS15715	COG0252	asparaginase activity
O6U12_RS15720	COG1309	transcriptional regulator
O6U12_RS15725	COG0477	Major facilitator Superfamily
O6U12_RS15730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O6U12_RS15735	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
O6U12_RS15740	COG0805	protein transport
O6U12_RS15745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O6U12_RS15750	COG3540	Alkaline phosphatase
O6U12_RS15765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_RS15770	COG1279	arginine transmembrane transporter activity
O6U12_RS15775	COG0626	cystathionine gamma-synthase activity
O6U12_RS15780	COG0137	argininosuccinate synthase activity
O6U12_RS15795	COG0531	amino acid
O6U12_RS15825	COG0072	phenylalanine-tRNA ligase activity
O6U12_RS15825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_RS15835	COG3773	Cell wall hydrolase
O6U12_RS15855	COG1131	(ABC) transporter
O6U12_RS15860	COG2205	protein histidine kinase activity
O6U12_RS15865	COG0745	RESPONSE REGULATOR receiver
O6U12_RS15870	COG0697	spore germination
O6U12_RS15885	COG2721	sulfolactate sulfo-lyase activity
O6U12_RS15890	COG2186	Transcriptional regulator
O6U12_RS15895	COG4948	Mandelate Racemase Muconate Lactonizing
O6U12_RS15900	COG2271	Major facilitator Superfamily
O6U12_RS15905	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS15910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O6U12_RS15915	COG0784	Response regulator, receiver
O6U12_RS15920	COG4191	Histidine kinase
O6U12_RS15925	COG2066	Belongs to the glutaminase family
O6U12_RS15930	COG1115	amino acid carrier protein
O6U12_RS15935	COG2040	homocysteine
O6U12_RS15940	COG0833	amino acid
O6U12_RS15945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O6U12_RS15955	COG2188	Transcriptional regulator
O6U12_RS15960	COG0363	glucosamine-6-phosphate deaminase activity
O6U12_RS15970	COG1301	dicarboxylic acid transport
O6U12_RS15975	COG1054	Belongs to the UPF0176 family
O6U12_RS15980	COG2312	Erythromycin esterase
O6U12_RS15990	COG0688	phosphatidylethanolamine metabolic process
O6U12_RS15995	COG0586	Pfam SNARE associated Golgi protein
O6U12_RS16000	COG1183	phosphatidylcholine synthase activity
O6U12_RS16005	COG0596	Alpha beta hydrolase
O6U12_RS16015	COG3591	Belongs to the peptidase S1B family
O6U12_RS16020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O6U12_RS16025	COG1917	Cupin 2, conserved barrel domain protein
O6U12_RS16025	COG2207	Transcriptional regulator
O6U12_RS16030	COG0697	spore germination
O6U12_RS16035	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS16045	COG2271	Major facilitator Superfamily
O6U12_RS16050	COG1846	Transcriptional regulator
O6U12_RS16050	COG0456	acetyltransferase
O6U12_RS16060	COG2271	Major facilitator Superfamily
O6U12_RS16065	COG0584	glycerophosphoryl diester phosphodiesterase
O6U12_RS16070	COG0531	amino acid
O6U12_RS16080	COG2124	cytochrome p450
O6U12_RS16085	COG2602	Beta-lactamase
O6U12_RS16100	COG1113	amino acid transport
O6U12_RS16115	COG0515	serine threonine protein kinase
O6U12_RS16125	COG0642	Histidine kinase
O6U12_RS16130	COG0745	RESPONSE REGULATOR receiver
O6U12_RS16135	COG0596	Alpha beta hydrolase
O6U12_RS16140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS16145	COG1413	lyase activity
O6U12_RS16155	COG1131	(ABC) transporter
O6U12_RS16160	COG1266	CAAX protease self-immunity
O6U12_RS16165	COG0535	radical SAM domain protein
O6U12_RS16180	COG2814	Major facilitator Superfamily
O6U12_RS16185	COG0640	Transcriptional regulator
O6U12_RS16190	COG5609	conserved protein (DUF2294)
O6U12_RS16200	COG0288	reversible hydration of carbon dioxide
O6U12_RS16205	COG3002	Belongs to the UPF0753 family
O6U12_RS16210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O6U12_RS16215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O6U12_RS16220	COG2169	Transcriptional regulator
O6U12_RS16225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O6U12_RS16310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_RS16325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O6U12_RS16330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O6U12_RS16335	COG4856	YbbR-like protein
O6U12_RS16340	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O6U12_RS16345	COG5662	AntiSigma factor
O6U12_RS16350	COG1595	DNA-templated transcription, initiation
O6U12_RS16380	COG1683	Conserved Protein
O6U12_RS16390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O6U12_RS16395	COG1737	Transcriptional regulator
O6U12_RS16400	COG1263	PTS System
O6U12_RS16400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_RS16405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O6U12_RS16415	COG3876	Protein conserved in bacteria
O6U12_RS16420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_RS16420	COG2207	Transcriptional regulator
O6U12_RS16425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_RS16430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_RS16435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_RS16440	COG2819	hydrolase of the alpha beta superfamily
O6U12_RS16445	COG0385	Bile acid
O6U12_RS16450	COG0659	secondary active sulfate transmembrane transporter activity
O6U12_RS16520	COG0726	polysaccharide deacetylase
O6U12_RS16525	COG2194	sulfuric ester hydrolase activity
O6U12_RS16535	COG0489	protein tyrosine kinase activity
O6U12_RS16540	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS16550	COG2226	methyltransferase
O6U12_RS16555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O6U12_RS16560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O6U12_RS16565	COG0101	tRNA pseudouridine synthase activity
O6U12_RS16570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O6U12_RS16575	COG1122	ATPase activity
O6U12_RS16580	COG1122	ATPase activity
O6U12_RS16585	COG0203	ribosomal protein L17
O6U12_RS16590	COG0202	RNA polymerase activity
O6U12_RS16595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O6U12_RS16600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O6U12_RS16605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O6U12_RS16615	COG2163	COG2163 Ribosomal protein L14E L6E L27E
O6U12_RS16620	COG0024	Methionine aminopeptidase
O6U12_RS16625	COG0563	adenylate kinase activity
O6U12_RS16630	COG0201	protein transport
O6U12_RS16635	COG0200	Binds to the 23S rRNA
O6U12_RS16645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O6U12_RS16650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O6U12_RS16655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O6U12_RS16660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O6U12_RS16670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O6U12_RS16685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O6U12_RS16695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O6U12_RS16700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O6U12_RS16715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O6U12_RS16725	COG0088	Forms part of the polypeptide exit tunnel
O6U12_RS16730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O6U12_RS16740	COG0596	Alpha beta hydrolase
O6U12_RS16745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O6U12_RS16750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O6U12_RS16755	COG0049	tRNA binding
O6U12_RS16760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O6U12_RS16765	COG1358	cellular component organization or biogenesis
O6U12_RS16770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O6U12_RS16775	COG0085	RNA polymerase activity
O6U12_RS16780	COG2813	Specifically methylates the guanine in position
O6U12_RS16790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O6U12_RS16795	COG0081	regulation of translation
O6U12_RS16805	COG0250	Participates in transcription elongation, termination and antitermination
O6U12_RS16810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O6U12_RS16820	COG1595	DNA-templated transcription, initiation
O6U12_RS16825	COG3688	RNA-binding protein containing a PIN domain
O6U12_RS16830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O6U12_RS16835	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
O6U12_RS16840	COG0215	cysteine-tRNA ligase activity
O6U12_RS16845	COG1045	serine acetyltransferase
O6U12_RS16850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O6U12_RS16855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O6U12_RS16860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O6U12_RS16865	COG4956	integral membrane protein (PIN domain superfamily)
O6U12_RS16870	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
O6U12_RS16875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O6U12_RS16880	COG0542	response to heat
O6U12_RS16885	COG3869	Catalyzes the specific phosphorylation of arginine residues in
O6U12_RS16890	COG3880	PFAM UvrB UvrC protein
O6U12_RS16895	COG4463	regulation of RNA biosynthetic process
O6U12_RS16975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O6U12_RS16980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O6U12_RS16985	COG1396	sequence-specific DNA binding
O6U12_RS16990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O6U12_RS16995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O6U12_RS17000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O6U12_RS17005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O6U12_RS17010	COG0512	Glutamine amidotransferase of anthranilate synthase
O6U12_RS17015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O6U12_RS17020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O6U12_RS17025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O6U12_RS17030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O6U12_RS17035	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O6U12_RS17040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O6U12_RS17045	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O6U12_RS17050	COG0037	tRNA processing
O6U12_RS17055	COG0515	serine threonine protein kinase
O6U12_RS17060	COG2304	oxidoreductase activity
O6U12_RS17065	COG2208	phosphoserine phosphatase activity
O6U12_RS17080	COG1098	S1 RNA binding domain
O6U12_RS17085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O6U12_RS17100	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O6U12_RS17105	COG3956	TIGRFAM MazG family protein
O6U12_RS17110	COG2244	polysaccharide biosynthetic process
O6U12_RS17115	COG2002	toxin-antitoxin pair type II binding
O6U12_RS17120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O6U12_RS17130	COG0193	aminoacyl-tRNA hydrolase activity
O6U12_RS17135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O6U12_RS17140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O6U12_RS17145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O6U12_RS17150	COG2088	sporulation resulting in formation of a cellular spore
O6U12_RS17155	COG0251	oxidation-reduction process
O6U12_RS17160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O6U12_RS17165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O6U12_RS17175	COG4466	Protein conserved in bacteria
O6U12_RS17185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O6U12_RS17190	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O6U12_RS17195	COG3583	domain protein
O6U12_RS17195	COG3584	3D domain protein
O6U12_RS17200	COG0084	hydrolase, TatD family'
O6U12_RS17205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_RS17205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_RS17210	COG2002	toxin-antitoxin pair type II binding
O6U12_RS17215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O6U12_RS17220	COG2827	Endonuclease containing a URI domain
O6U12_RS17225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O6U12_RS17230	COG4467	Involved in initiation control of chromosome replication
O6U12_RS17235	COG1774	PSP1 C-terminal conserved region
O6U12_RS17240	COG0470	DNA polymerase III
O6U12_RS17245	COG1728	Protein conserved in bacteria
O6U12_RS17250	COG3870	Protein conserved in bacteria
O6U12_RS17255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O6U12_RS17260	COG1982	Orn Lys Arg decarboxylase major
O6U12_RS17265	COG3853	Toxic anion resistance protein (TelA)
O6U12_RS17270	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
O6U12_RS17315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O6U12_RS17320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O6U12_RS17325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O6U12_RS17335	COG0590	tRNA wobble adenosine to inosine editing
O6U12_RS17340	COG1335	isochorismatase
O6U12_RS17345	COG3858	chitin binding
O6U12_RS17345	COG1388	LysM domain
O6U12_RS17350	COG1428	Deoxynucleoside kinase
O6U12_RS17355	COG1428	Deoxynucleoside kinase
O6U12_RS17365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O6U12_RS17370	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
O6U12_RS17375	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
O6U12_RS17380	COG1686	Belongs to the peptidase S11 family
O6U12_RS17385	COG0516	GMP reductase activity
O6U12_RS17385	COG0517	IMP dehydrogenase activity
O6U12_RS17425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O6U12_RS17430	COG0187	DNA topoisomerase II activity
O6U12_RS17440	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O6U12_RS17445	COG2501	S4 domain
O6U12_RS17450	COG0592	DNA-directed DNA polymerase activity
O6U12_RS17455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O6U12_RS17465	COG0594	ribonuclease P activity
O6U12_RS17470	COG0706	membrane insertase activity
O6U12_RS17475	COG1847	R3H domain protein
O6U12_RS17480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O6U12_RS17485	COG0445	tRNA wobble uridine modification
O6U12_RS17490	COG0357	Ribosomal RNA small subunit methyltransferase G
O6U12_RS17495	COG1475	DNA binding
O6U12_RS17505	COG1192	Involved in chromosome partitioning
O6U12_RS17510	COG1475	DNA binding
O6U12_RS17520	COG3949	Membrane
O6U12_RS17525	COG4481	Protein conserved in bacteria
O6U12_RS17530	COG0243	molybdopterin cofactor binding
O6U12_RS17535	COG0012	GTP binding
O6U12_RS17540	COG0360	Binds together with S18 to 16S ribosomal RNA
O6U12_RS17545	COG0629	single-stranded DNA binding
O6U12_RS17550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O6U12_RS17555	COG0708	Exodeoxyribonuclease III
O6U12_RS17560	COG1609	Transcriptional regulator
O6U12_RS17565	COG0346	lactoylglutathione lyase activity
O6U12_RS17570	COG0110	maltose O-acetyltransferase activity
O6U12_RS17575	COG0477	Major facilitator Superfamily
O6U12_RS17575	COG2814	Major facilitator Superfamily
O6U12_RS17580	COG1266	CAAX protease self-immunity
O6U12_RS17585	COG1331	Highly conserved protein containing a thioredoxin domain
O6U12_RS17590	COG2814	Major facilitator Superfamily
O6U12_RS17600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O6U12_RS17610	COG0456	acetyltransferase
O6U12_RS17615	COG2364	Membrane
O6U12_RS17625	COG1846	Transcriptional regulator
O6U12_RS17630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_RS17645	COG2153	protein acetylation
O6U12_RS17650	COG0583	DNA-binding transcription factor activity
O6U12_RS17655	COG2814	Major facilitator Superfamily
O6U12_RS17660	COG1357	PFAM Pentapeptide repeats (8 copies)
O6U12_RS17665	COG4319	ketosteroid isomerase
O6U12_RS17680	COG2271	Major facilitator Superfamily
O6U12_RS17695	COG1227	inorganic diphosphatase activity
O6U12_RS17700	COG1733	regulation of RNA biosynthetic process
O6U12_RS17715	COG4241	membrane
O6U12_RS17720	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
O6U12_RS17725	COG0359	binds to the 23S rRNA
O6U12_RS17730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O6U12_RS17735	COG2807	transmembrane transport
O6U12_RS17740	COG3093	addiction module antidote protein HigA
O6U12_RS17755	COG0305	Participates in initiation and elongation during chromosome replication
O6U12_RS17760	COG0346	lactoylglutathione lyase activity
O6U12_RS17790	COG0745	RESPONSE REGULATOR receiver
O6U12_RS17795	COG5002	protein histidine kinase activity
O6U12_RS17800	COG4863	YycH protein
O6U12_RS17805	COG4853	Protein conserved in bacteria
O6U12_RS17810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O6U12_RS17815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O6U12_RS17830	COG3829	transcription factor binding
O6U12_RS17835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O6U12_RS17840	COG0833	amino acid
O6U12_RS17845	COG0010	Belongs to the arginase family
O6U12_RS17855	COG0457	Tetratricopeptide repeat
O6U12_RS17860	COG0456	acetyltransferase
O6U12_RS17865	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
O6U12_RS17885	COG1063	alcohol dehydrogenase
O6U12_RS17900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O6U12_RS17935	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
O6U12_RS17945	COG0535	radical SAM domain protein
O6U12_RS17950	COG1994	Peptidase M50
O6U12_RS17955	COG1131	(ABC) transporter
O6U12_RS17970	COG2188	Transcriptional regulator
O6U12_RS17985	COG2723	6-phospho-beta-galactosidase activity
O6U12_RS17990	COG3634	alkyl hydroperoxide reductase activity
O6U12_RS17995	COG0450	alkyl hydroperoxide reductase
O6U12_RS18000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O6U12_RS18005	COG2610	gluconate transmembrane transporter activity
O6U12_RS18010	COG1070	Carbohydrate kinase
O6U12_RS18015	COG1802	Transcriptional regulator
O6U12_RS18020	COG1929	Belongs to the glycerate kinase type-1 family
O6U12_RS18030	COG1346	cytolysis
O6U12_RS18035	COG1380	Effector of murein hydrolase LrgA
O6U12_RS18040	COG1846	Transcriptional regulator
O6U12_RS18050	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS18055	COG1309	transcriptional regulator
O6U12_RS18060	COG1917	Cupin 2, conserved barrel domain protein
O6U12_RS18065	COG2311	Membrane
O6U12_RS18070	COG1714	RDD family
O6U12_RS18080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O6U12_RS18095	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS18100	COG1309	transcriptional regulator
O6U12_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS18115	COG0326	Molecular chaperone. Has ATPase activity
O6U12_RS18120	COG2814	Major facilitator Superfamily
O6U12_RS18135	COG0667	Aldo Keto reductase
O6U12_RS18140	COG1349	DNA-binding transcription factor activity
O6U12_RS18145	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS18150	COG3718	enzyme involved in inositol metabolism
O6U12_RS18155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O6U12_RS18160	COG3962	Belongs to the TPP enzyme family
O6U12_RS18165	COG1082	Xylose isomerase domain protein TIM barrel
O6U12_RS18170	COG2814	Major facilitator Superfamily
O6U12_RS18175	COG0673	inositol 2-dehydrogenase activity
O6U12_RS18180	COG1082	Xylose isomerase domain protein TIM barrel
O6U12_RS18185	COG1082	Xylose isomerase domain protein TIM barrel
O6U12_RS18190	COG0191	fructose-bisphosphate aldolase activity
O6U12_RS18195	COG0745	RESPONSE REGULATOR receiver
O6U12_RS18200	COG2205	protein histidine kinase activity
O6U12_RS18205	COG1136	(ABC) transporter
O6U12_RS18210	COG0577	efflux transmembrane transporter activity
O6U12_RS18215	COG5294	Protein conserved in bacteria
O6U12_RS18220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_RS18250	COG0561	phosphatase activity
O6U12_RS18255	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
O6U12_RS18260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_RS18265	COG0456	acetyltransferase
O6U12_RS18270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_RS18275	COG0765	amino acid transport
O6U12_RS18280	COG1126	abc transporter atp-binding protein
O6U12_RS18285	COG1473	amidohydrolase
O6U12_RS18290	COG2079	MmgE PrpD family protein
O6U12_RS18295	COG3192	ethanolamine utilization protein
O6U12_RS18305	COG2390	Transcriptional regulator
O6U12_RS18310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O6U12_RS18315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O6U12_RS18320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
O6U12_RS18335	COG1228	amidohydrolase
O6U12_RS18345	COG3507	Belongs to the glycosyl hydrolase 43 family
O6U12_RS18350	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
O6U12_RS18355	COG0494	nUDIX hydrolase
O6U12_RS18375	COG5444	nuclease activity
O6U12_RS18385	COG1263	PTS System
O6U12_RS18385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_RS18385	COG2190	(PTS) system
O6U12_RS18390	COG2723	6-phospho-beta-galactosidase activity
O6U12_RS18395	COG0589	response to stress
O6U12_RS18405	COG0697	spore germination
O6U12_RS18410	COG3209	COG3209 Rhs family protein
O6U12_RS18465	COG2755	lipolytic protein G-D-S-L family
O6U12_RS18465	COG3401	FG-GAP repeat protein
O6U12_RS18470	COG0513	Belongs to the DEAD box helicase family
O6U12_RS18475	COG2270	Major facilitator Superfamily
O6U12_RS18495	COG2851	Citrate transporter
O6U12_RS18500	COG0693	protein deglycase activity
O6U12_RS18500	COG0753	catalase activity
O6U12_RS18515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O6U12_RS18530	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS18550	COG3546	catalase activity
O6U12_RS18570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_RS18585	COG2323	membrane
O6U12_RS18595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_RS18600	COG2323	membrane
O6U12_RS18605	COG0500	methyltransferase
O6U12_RS18610	COG2610	gluconate transmembrane transporter activity
O6U12_RS18615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O6U12_RS18620	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O6U12_RS18630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O6U12_RS18635	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O6U12_RS18640	COG4894	glucomannan catabolic process
O6U12_RS18655	COG2195	Cleaves the N-terminal amino acid of tripeptides
O6U12_RS18660	COG2197	response regulator
O6U12_RS18665	COG4585	Histidine kinase
O6U12_RS18675	COG0583	DNA-binding transcription factor activity
O6U12_RS18680	COG1881	PFAM PEBP family protein
O6U12_RS18685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O6U12_RS18695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_RS18700	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS18705	COG2508	Transcriptional regulator
O6U12_RS18710	COG3842	ATPase activity
O6U12_RS18715	COG0726	polysaccharide deacetylase
O6U12_RS18725	COG0501	Belongs to the peptidase M48B family
O6U12_RS18730	COG3493	citrate carrier protein
O6U12_RS18735	COG1271	oxidase subunit
O6U12_RS18740	COG1294	oxidase, subunit
O6U12_RS18745	COG4988	ABC transporter
O6U12_RS18750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O6U12_RS18755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O6U12_RS18760	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O6U12_RS18765	COG1595	DNA-templated transcription, initiation
O6U12_RS18785	COG1131	(ABC) transporter
O6U12_RS18800	COG0753	catalase activity
O6U12_RS18805	COG2094	Belongs to the DNA glycosylase MPG family
O6U12_RS18815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_RS18815	COG3711	transcriptional antiterminator
O6U12_RS18820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O6U12_RS18825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O6U12_RS18830	COG1447	Phosphotransferase system cellobiose-specific component IIA
O6U12_RS18835	COG1486	melibiose metabolic process
O6U12_RS18840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O6U12_RS18845	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
O6U12_RS18850	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
O6U12_RS18855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O6U12_RS18860	COG1696	Membrane protein involved in D-alanine export
O6U12_RS18865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_RS18880	COG1575	Belongs to the MenA family. Type 1 subfamily
O6U12_RS18885	COG2357	RelA SpoT domain protein
O6U12_RS18890	COG2814	Major facilitator Superfamily
O6U12_RS18910	COG2234	aminopeptidase activity
O6U12_RS18915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O6U12_RS18920	COG1846	Transcriptional regulator
O6U12_RS18930	COG1442	glycosyl transferase family 8
O6U12_RS18935	COG3711	transcriptional antiterminator
O6U12_RS18940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_RS18940	COG1263	PTS System
O6U12_RS18945	COG1404	Belongs to the peptidase S8 family
O6U12_RS18960	COG0346	lactoylglutathione lyase activity
O6U12_RS18965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O6U12_RS18970	COG4895	conserved protein (DUF2196)
O6U12_RS18975	COG2814	Major facilitator Superfamily
O6U12_RS18980	COG1346	cytolysis
O6U12_RS18985	COG1380	Effector of murein hydrolase LrgA
O6U12_RS18990	COG0583	DNA-binding transcription factor activity
O6U12_RS18995	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
O6U12_RS19000	COG0352	thiamine-phosphate diphosphorylase activity
O6U12_RS19005	COG0672	)-iron permease
O6U12_RS19010	COG2822	iron ion transport
O6U12_RS19015	COG2837	iron assimilation
O6U12_RS19020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O6U12_RS19025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_RS19030	COG3162	membrane
O6U12_RS19040	COG1309	transcriptional regulator
O6U12_RS19045	COG2246	polysaccharide biosynthetic process
O6U12_RS19050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O6U12_RS19055	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
O6U12_RS19060	COG2261	transglycosylase associated protein
O6U12_RS19065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O6U12_RS19070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O6U12_RS19075	COG1845	cytochrome c oxidase, subunit III
O6U12_RS19080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O6U12_RS19095	COG0772	Belongs to the SEDS family
O6U12_RS19100	COG0778	Nitroreductase
O6U12_RS19105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_RS19110	COG1404	Belongs to the peptidase S8 family
O6U12_RS19120	COG3711	transcriptional antiterminator
O6U12_RS19125	COG2116	formate transmembrane transporter activity
O6U12_RS19130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_RS19130	COG1263	PTS System
O6U12_RS19135	COG1621	beta-fructofuranosidase activity
O6U12_RS19145	COG0351	phosphomethylpyrimidine kinase
O6U12_RS19150	COG1695	Transcriptional regulator
O6U12_RS19165	COG1216	Glycosyl transferase, family 2
O6U12_RS19170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O6U12_RS19175	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS19185	COG2233	PERMEase
O6U12_RS19190	COG2363	Small membrane protein
O6U12_RS19200	COG0463	Glycosyl transferase, family 2
O6U12_RS19205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O6U12_RS19210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O6U12_RS19215	COG0456	acetyltransferase
O6U12_RS19220	COG2089	acid synthase
O6U12_RS19225	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
O6U12_RS19230	COG3980	spore coat polysaccharide biosynthesis protein
O6U12_RS19235	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O6U12_RS19240	COG1088	dTDP-glucose 4,6-dehydratase activity
O6U12_RS19245	COG1091	dTDP-4-dehydrorhamnose reductase activity
O6U12_RS19250	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
O6U12_RS19265	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_RS19270	COG4187	Peptidase family M20/M25/M40
O6U12_RS19275	COG0833	amino acid
O6U12_RS19280	COG2814	Major facilitator Superfamily
O6U12_RS19285	COG0077	Prephenate dehydratase
O6U12_RS19295	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS19300	COG0151	Belongs to the GarS family
O6U12_RS19305	COG2814	Major facilitator Superfamily
O6U12_RS19310	COG0436	Aminotransferase
O6U12_RS19320	COG3253	May function as heme-dependent peroxidase
O6U12_RS19325	COG0280	phosphate acetyltransferase
O6U12_RS19330	COG0583	DNA-binding transcription factor activity
O6U12_RS19335	COG0095	Lipoate-protein ligase
O6U12_RS19340	COG0697	spore germination
O6U12_RS19350	COG4844	belongs to the
O6U12_RS19355	COG1078	dGTPase activity
O6U12_RS19360	COG3465	dGTPase activity
O6U12_RS19365	COG1959	2 iron, 2 sulfur cluster binding
O6U12_RS19370	COG0477	Major facilitator Superfamily
O6U12_RS19375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O6U12_RS19380	COG1846	Transcriptional regulator
O6U12_RS19385	COG1942	4-Oxalocrotonate Tautomerase
O6U12_RS19390	COG1994	Peptidase M50
O6U12_RS19400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O6U12_RS19405	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O6U12_RS19410	COG0010	Belongs to the arginase family
O6U12_RS19425	COG0457	Tetratricopeptide repeat
O6U12_RS19430	COG3391	amine dehydrogenase activity
O6U12_RS19435	COG3391	amine dehydrogenase activity
O6U12_RS19445	COG0612	Peptidase, M16
O6U12_RS19450	COG0612	Peptidase, M16
O6U12_RS19455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O6U12_RS19460	COG1131	(ABC) transporter
O6U12_RS19470	COG0535	radical SAM domain protein
O6U12_RS19485	COG4506	Protein conserved in bacteria
O6U12_RS19490	COG0018	arginyl-trna synthetase
O6U12_RS19495	COG2223	nitrite transmembrane transporter activity
O6U12_RS19500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O6U12_RS19510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O6U12_RS19515	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
O6U12_RS19520	COG1140	nitrate reductase beta subunit
O6U12_RS19525	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
O6U12_RS19530	COG2181	nitrate reductase activity
O6U12_RS19540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_RS19545	COG1132	(ABC) transporter
O6U12_RS19550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O6U12_RS19560	COG4294	response to UV
O6U12_RS19565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_RS19570	COG0247	lactate metabolic process
O6U12_RS19570	COG2181	nitrate reductase activity
O6U12_RS19575	COG1960	acyl-CoA dehydrogenase activity
O6U12_RS19580	COG3343	RNA polymerase activity
O6U12_RS19585	COG0504	CTP synthase activity
O6U12_RS19590	COG2801	Transposase and inactivated derivatives
O6U12_RS19600	COG4821	SIS domain
O6U12_RS19605	COG2204	response regulator
O6U12_RS19610	COG0191	fructose-bisphosphate aldolase activity
O6U12_RS19615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O6U12_RS19620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O6U12_RS19625	COG1494	fructose-1,6-bisphosphatase
O6U12_RS19635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O6U12_RS19645	COG1435	thymidine kinase activity
O6U12_RS19650	COG0281	malic enzyme
O6U12_RS19655	COG0679	Auxin Efflux Carrier
O6U12_RS19660	COG0789	Transcriptional regulator
O6U12_RS19665	COG0346	lactoylglutathione lyase activity
O6U12_RS19670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O6U12_RS19675	COG2890	protein-(glutamine-N5) methyltransferase activity
O6U12_RS19695	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O6U12_RS19700	COG0009	L-threonylcarbamoyladenylate synthase
O6U12_RS19705	COG1971	Probably functions as a manganese efflux pump
O6U12_RS19710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O6U12_RS19715	COG0698	ribose 5-phosphate isomerase
O6U12_RS19720	COG4475	Protein of unknown function (DUF436)
O6U12_RS19725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O6U12_RS19730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O6U12_RS19740	COG0356	it plays a direct role in the translocation of protons across the membrane
O6U12_RS19750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O6U12_RS19755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O6U12_RS19760	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O6U12_RS19765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O6U12_RS19770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O6U12_RS19775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O6U12_RS19785	COG4836	Membrane
O6U12_RS19795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O6U12_RS19800	COG2385	sporulation resulting in formation of a cellular spore
O6U12_RS19815	COG2304	oxidoreductase activity
O6U12_RS19825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O6U12_RS19830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O6U12_RS19835	COG0457	Tetratricopeptide repeat
O6U12_RS19840	COG1994	Peptidase M50
O6U12_RS19845	COG3237	CsbD-like
O6U12_RS19875	COG0831	urea catabolic process
O6U12_RS19880	COG0832	Belongs to the urease beta subunit family
O6U12_RS19885	COG0804	urea catabolic process
O6U12_RS19890	COG1959	2 iron, 2 sulfur cluster binding
O6U12_RS19895	COG2910	NAD(P)H-binding
O6U12_RS19905	COG0789	Transcriptional regulator
O6U12_RS19910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_RS19930	COG1247	-acetyltransferase
O6U12_RS19935	COG0739	heme binding
O6U12_RS19945	COG0671	phosphoesterase, PA-phosphatase related
O6U12_RS19950	COG0347	Belongs to the P(II) protein family
O6U12_RS19955	COG0004	ammonium transporteR
O6U12_RS19965	COG1335	isochorismatase
O6U12_RS19970	COG0477	Major facilitator Superfamily
O6U12_RS19975	COG1953	Uracil, thiamine, allantoin
O6U12_RS19980	COG3420	alginic acid biosynthetic process
O6U12_RS19985	COG2814	Major facilitator Superfamily
O6U12_RS19990	COG1846	Transcriptional regulator
O6U12_RS20000	COG1609	Transcriptional regulator
O6U12_RS20005	COG1077	Cell shape determining protein MreB Mrl
O6U12_RS20010	COG4786	Flagellar basal body rod
O6U12_RS20015	COG4786	Flagellar basal body rod
O6U12_RS20020	COG0457	Tetratricopeptide repeat
O6U12_RS20025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O6U12_RS20030	COG1970	mechanosensitive ion channel activity
O6U12_RS20035	COG0745	RESPONSE REGULATOR receiver
O6U12_RS20035	COG2972	Histidine kinase
O6U12_RS20050	COG3328	transposase activity
O6U12_RS20065	COG0629	single-stranded DNA binding
O6U12_RS20070	COG1349	DNA-binding transcription factor activity
O6U12_RS20075	COG0561	phosphatase activity
O6U12_RS20080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O6U12_RS20085	COG4715	Zinc finger, swim domain protein
O6U12_RS20095	COG3944	biosynthesis protein
O6U12_RS20100	COG0489	protein tyrosine kinase activity
O6U12_RS20105	COG4464	protein tyrosine phosphatase activity
O6U12_RS20110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O6U12_RS20130	COG5444	nuclease activity
O6U12_RS20145	COG0583	DNA-binding transcription factor activity
O6U12_RS20160	COG2059	Chromate
O6U12_RS20165	COG2059	Chromate
O6U12_RS20170	COG1522	sequence-specific DNA binding
O6U12_RS20175	COG0405	Gamma-glutamyltransferase
O6U12_RS20185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O6U12_RS20195	COG5337	Spore coat protein CotH
O6U12_RS20215	COG0583	DNA-binding transcription factor activity
O6U12_RS20220	COG0028	Belongs to the TPP enzyme family
O6U12_RS20225	COG3527	Alpha-acetolactate decarboxylase
O6U12_RS20230	COG2249	NAD(P)H dehydrogenase (quinone) activity
O6U12_RS20240	COG3103	Sh3 type 3 domain protein
O6U12_RS20245	COG1879	ABC-type sugar transport system periplasmic component
O6U12_RS20250	COG1172	Belongs to the binding-protein-dependent transport system permease family
O6U12_RS20255	COG1129	ABC transporter
O6U12_RS20260	COG1869	D-ribose catabolic process
O6U12_RS20265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O6U12_RS20270	COG1609	Transcriptional regulator
O6U12_RS20275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O6U12_RS20285	COG2843	Capsule synthesis protein
O6U12_RS20295	COG0791	NLP P60 protein
O6U12_RS20305	COG0561	phosphatase activity
O6U12_RS20310	COG1316	TRANSCRIPTIONal
O6U12_RS20315	COG2814	Major facilitator Superfamily
O6U12_RS20325	COG0814	amino acid
O6U12_RS20330	COG0697	spore germination
O6U12_RS20335	COG1482	cell wall glycoprotein biosynthetic process
O6U12_RS20340	COG4193	domain, Protein
O6U12_RS20350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O6U12_RS20355	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
O6U12_RS20360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
O6U12_RS20365	COG0438	transferase activity, transferring glycosyl groups
O6U12_RS20370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O6U12_RS20375	COG1682	transport, permease protein
O6U12_RS20380	COG1134	teichoic acid transport
O6U12_RS20400	COG0463	Glycosyl transferase, family 2
O6U12_RS20405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O6U12_RS20405	COG1215	transferase activity, transferring glycosyl groups
O6U12_RS20415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O6U12_RS20420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O6U12_RS20425	COG1316	TRANSCRIPTIONal
O6U12_RS20435	COG2385	sporulation resulting in formation of a cellular spore
O6U12_RS20435	COG2247	cell wall binding repeat
O6U12_RS20440	COG2247	cell wall binding repeat
O6U12_RS20440	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS20450	COG2244	polysaccharide biosynthetic process
O6U12_RS20455	COG0438	transferase activity, transferring glycosyl groups
O6U12_RS20455	COG0297	glycogen (starch) synthase activity
O6U12_RS20460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O6U12_RS20465	COG3307	-O-antigen
O6U12_RS20470	COG3206	protein involved in exopolysaccharide biosynthesis
O6U12_RS20475	COG1215	transferase activity, transferring glycosyl groups
O6U12_RS20480	COG0438	transferase activity, transferring glycosyl groups
O6U12_RS20485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O6U12_RS20490	COG1316	TRANSCRIPTIONal
O6U12_RS20495	COG1739	Uncharacterized protein family UPF0029
O6U12_RS20500	COG4585	Histidine kinase
O6U12_RS20505	COG2197	response regulator
O6U12_RS20510	COG1307	EDD domain protein, DegV family
O6U12_RS20515	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
O6U12_RS20525	COG1040	competence protein
O6U12_RS20535	COG2747	anti-sigma28 factor FlgM
O6U12_RS20540	COG3418	PFAM FlgN family protein
O6U12_RS20545	COG4786	Flagellar basal body rod
O6U12_RS20545	COG1256	bacterial-type flagellum assembly
O6U12_RS20550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O6U12_RS20560	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
O6U12_RS20565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O6U12_RS20570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O6U12_RS20575	COG1334	flagellar protein FlaG
O6U12_RS20580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O6U12_RS20585	COG1516	flagellar protein fliS
O6U12_RS20600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O6U12_RS20605	COG0653	protein targeting
O6U12_RS20615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_RS20620	COG2010	Cytochrome c
O6U12_RS20625	COG2884	Cell division ATP-binding protein ftsE
O6U12_RS20630	COG2177	Part of the ABC transporter FtsEX involved in
O6U12_RS20635	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS20635	COG0793	Belongs to the peptidase S41A family
O6U12_RS20645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O6U12_RS20650	COG2814	Major facilitator Superfamily
O6U12_RS20655	COG1309	transcriptional regulator
O6U12_RS20660	COG0574	Belongs to the PEP-utilizing enzyme family
O6U12_RS20660	COG3848	Pyruvate phosphate dikinase
O6U12_RS20665	COG4897	Protein conserved in bacteria
O6U12_RS20670	COG0556	nucleotide-excision repair
O6U12_RS20675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O6U12_RS20695	COG3595	metallopeptidase activity
O6U12_RS20700	COG1983	PspC domain protein
O6U12_RS20705	COG1950	PFAM Membrane protein of
O6U12_RS20710	COG2814	Major facilitator Superfamily
O6U12_RS20715	COG1846	Transcriptional regulator
O6U12_RS20725	COG2124	cytochrome p450
O6U12_RS20730	COG1846	Transcriptional regulator
O6U12_RS20735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O6U12_RS20740	COG2188	Transcriptional regulator
O6U12_RS20745	COG0363	glucosamine-6-phosphate deaminase activity
O6U12_RS20750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O6U12_RS20755	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
O6U12_RS20760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O6U12_RS20765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
O6U12_RS20770	COG0546	phosphoglycolate phosphatase activity
O6U12_RS20775	COG0110	maltose O-acetyltransferase activity
O6U12_RS20780	COG5297	Belongs to the glycosyl hydrolase family 6
O6U12_RS20785	COG4990	cell redox homeostasis
O6U12_RS20790	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
O6U12_RS20795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O6U12_RS20800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O6U12_RS20805	COG0131	Imidazoleglycerol-phosphate dehydratase
O6U12_RS20810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O6U12_RS20815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O6U12_RS20820	COG0107	imidazoleglycerol-phosphate synthase activity
O6U12_RS20825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O6U12_RS20825	COG0140	phosphoribosyl-ATP diphosphatase activity
O6U12_RS20850	COG0457	Tetratricopeptide repeat
O6U12_RS20855	COG0791	NLP P60 protein
O6U12_RS20855	COG3883	PFAM NLP P60 protein
O6U12_RS20860	COG0492	ferredoxin-NADP+ reductase activity
O6U12_RS20865	COG1051	belongs to the nudix hydrolase family
O6U12_RS20870	COG1660	Displays ATPase and GTPase activities
O6U12_RS20875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O6U12_RS20880	COG1481	regulation of sporulation
O6U12_RS20885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_RS20890	COG2162	N-hydroxyarylamine O-acetyltransferase activity
O6U12_RS20900	COG0745	RESPONSE REGULATOR receiver
O6U12_RS20905	COG5002	protein histidine kinase activity
O6U12_RS20910	COG1136	(ABC) transporter
O6U12_RS20915	COG0577	efflux transmembrane transporter activity
O6U12_RS20920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O6U12_RS20925	COG0288	reversible hydration of carbon dioxide
O6U12_RS20930	COG0659	secondary active sulfate transmembrane transporter activity
O6U12_RS20935	COG1694	Mazg nucleotide pyrophosphohydrolase
O6U12_RS20940	COG1611	Belongs to the LOG family
O6U12_RS20945	COG1609	Transcriptional regulator
O6U12_RS20950	COG0366	Alpha amylase catalytic
O6U12_RS20955	COG2182	Extracellular solute-binding protein
O6U12_RS20960	COG1175	transmembrane transport
O6U12_RS20965	COG3833	ABC-type maltose transport systems, permease component
O6U12_RS20970	COG5521	maltodextrose utilization protein MalA
O6U12_RS20975	COG1554	hydrolase, family 65, central catalytic
O6U12_RS20980	COG0366	Alpha amylase catalytic
O6U12_RS20985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O6U12_RS20990	COG0740	serine-type endopeptidase activity
O6U12_RS21005	COG2076	Multidrug Resistance protein
O6U12_RS21010	COG2076	Multidrug Resistance protein
O6U12_RS21015	COG1309	transcriptional regulator
O6U12_RS21020	COG0531	amino acid
O6U12_RS21025	COG1621	beta-fructofuranosidase activity
O6U12_RS21030	COG1621	beta-fructofuranosidase activity
O6U12_RS21035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O6U12_RS21040	COG1794	racemase activity, acting on amino acids and derivatives
O6U12_RS21050	COG3479	Phenolic acid decarboxylase
O6U12_RS21060	COG2272	Belongs to the type-B carboxylesterase lipase family
O6U12_RS21065	COG1396	sequence-specific DNA binding
O6U12_RS21070	COG3944	biosynthesis protein
O6U12_RS21075	COG0489	protein tyrosine kinase activity
O6U12_RS21080	COG1086	Polysaccharide biosynthesis protein
O6U12_RS21085	COG0438	transferase activity, transferring glycosyl groups
O6U12_RS21090	COG1215	transferase activity, transferring glycosyl groups
O6U12_RS21095	COG0438	transferase activity, transferring glycosyl groups
O6U12_RS21105	COG1216	Glycosyl transferase, family 2
O6U12_RS21110	COG5039	Polysaccharide pyruvyl transferase
O6U12_RS21115	COG1216	Glycosyl transferase, family 2
O6U12_RS21120	COG2244	polysaccharide biosynthetic process
O6U12_RS21125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O6U12_RS21130	COG0110	maltose O-acetyltransferase activity
O6U12_RS21135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O6U12_RS21140	COG5039	Polysaccharide pyruvyl transferase
O6U12_RS21150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O6U12_RS21155	COG1620	l-lactate permease
O6U12_RS21160	COG2186	Transcriptional regulator
O6U12_RS21165	COG1609	Transcriptional regulator
O6U12_RS21170	COG2182	Extracellular solute-binding protein
O6U12_RS21175	COG1175	transmembrane transport
O6U12_RS21180	COG3833	ABC-type maltose transport systems, permease component
O6U12_RS21185	COG1874	Beta-galactosidase
O6U12_RS21190	COG3867	Arabinogalactan endo-beta-1,4-galactanase
O6U12_RS21195	COG2208	phosphoserine phosphatase activity
O6U12_RS21200	COG0596	Alpha beta hydrolase
O6U12_RS21205	COG1131	(ABC) transporter
O6U12_RS21210	COG0842	Transport permease protein
O6U12_RS21215	COG4585	Histidine kinase
O6U12_RS21220	COG2197	response regulator
O6U12_RS21235	COG0247	lactate metabolic process
O6U12_RS21240	COG1139	Iron-sulfur cluster binding protein
O6U12_RS21245	COG1556	Lactate utilization protein
O6U12_RS21250	COG3858	chitin binding
O6U12_RS21255	COG1113	amino acid transport
O6U12_RS21260	COG0697	spore germination
O6U12_RS21265	COG0583	DNA-binding transcription factor activity
O6U12_RS21270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_RS21275	COG1609	Transcriptional regulator
O6U12_RS21280	COG2814	Major facilitator Superfamily
O6U12_RS21285	COG2390	Transcriptional regulator
O6U12_RS21290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O6U12_RS21295	COG0126	phosphoglycerate kinase activity
O6U12_RS21300	COG0149	triose-phosphate isomerase activity
O6U12_RS21305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O6U12_RS21310	COG0148	phosphopyruvate hydratase activity
O6U12_RS21315	COG0456	acetyltransferase
O6U12_RS21325	COG3064	Membrane
O6U12_RS21335	COG2095	MarC family integral membrane protein
O6U12_RS21340	COG1510	regulation of RNA biosynthetic process
O6U12_RS21345	COG0517	IMP dehydrogenase activity
O6U12_RS21345	COG1125	glycine betaine transport
O6U12_RS21350	COG1174	glycine betaine transport
O6U12_RS21355	COG1732	Glycine betaine
O6U12_RS21360	COG1174	glycine betaine transport
O6U12_RS21365	COG0640	Transcriptional regulator
O6U12_RS21370	COG5658	integral membrane protein
O6U12_RS21390	COG1510	regulation of RNA biosynthetic process
O6U12_RS21395	COG1125	glycine betaine transport
O6U12_RS21395	COG0517	IMP dehydrogenase activity
O6U12_RS21400	COG1174	glycine betaine transport
O6U12_RS21405	COG1732	Glycine betaine
O6U12_RS21410	COG1174	glycine betaine transport
O6U12_RS21415	COG0840	transmembrane signaling receptor activity
O6U12_RS21425	COG1733	regulation of RNA biosynthetic process
O6U12_RS21430	COG1396	sequence-specific DNA binding
O6U12_RS21435	COG1396	sequence-specific DNA binding
O6U12_RS21440	COG1476	TRANSCRIPTIONal
O6U12_RS21445	COG0596	Alpha beta hydrolase
O6U12_RS21450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O6U12_RS21455	COG1647	Serine aminopeptidase, S33
O6U12_RS21460	COG0557	exoribonuclease II activity
O6U12_RS21465	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O6U12_RS21480	COG1309	transcriptional regulator
O6U12_RS21485	COG2076	Multidrug Resistance protein
O6U12_RS21495	COG1289	transmembrane transporter activity
O6U12_RS21500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O6U12_RS21505	COG0673	inositol 2-dehydrogenase activity
O6U12_RS21510	COG1937	Protein conserved in bacteria
O6U12_RS21515	COG2608	mercury ion transmembrane transporter activity
O6U12_RS21520	COG2217	Heavy metal translocating P-type atpase
O6U12_RS21525	COG2217	Heavy metal translocating P-type atpase
O6U12_RS21530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O6U12_RS21535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O6U12_RS21540	COG2860	membrane
O6U12_RS21545	COG3973	AAA domain
O6U12_RS21550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O6U12_RS21555	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O6U12_RS21560	COG0025	NhaP-type Na H and K H
O6U12_RS21570	COG0656	L-ascorbic acid biosynthetic process
O6U12_RS21575	COG4149	molybdate abc transporter
O6U12_RS21580	COG0725	ABC transporter, periplasmic molybdate-binding protein
O6U12_RS21585	COG1910	domain protein
O6U12_RS21590	COG1368	sulfuric ester hydrolase activity
O6U12_RS21595	COG1988	membrane-bound metal-dependent
O6U12_RS21605	COG0531	amino acid
O6U12_RS21610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_RS21615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_RS21620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_RS21625	COG1120	ATPase activity
O6U12_RS21630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O6U12_RS21635	COG1136	(ABC) transporter
O6U12_RS21640	COG0577	efflux transmembrane transporter activity
O6U12_RS21650	COG2140	Oxalate decarboxylase
O6U12_RS21660	COG1191	sigma factor activity
O6U12_RS21670	COG0745	RESPONSE REGULATOR receiver
O6U12_RS21675	COG2205	protein histidine kinase activity
O6U12_RS21680	COG3386	PFAM SMP-30 Gluconolaconase
O6U12_RS21685	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS21690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_RS21695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_RS21700	COG1120	ATPase activity
O6U12_RS21705	COG2096	Adenosyltransferase
O6U12_RS21710	COG2814	Major facilitator Superfamily
O6U12_RS21715	COG4758	membrane
O6U12_RS21720	COG1842	Phage shock protein A
O6U12_RS21730	COG4758	membrane
O6U12_RS21735	COG4585	Histidine kinase
O6U12_RS21740	COG2197	response regulator
O6U12_RS21750	COG0814	amino acid
O6U12_RS21755	COG0697	spore germination
O6U12_RS21765	COG0114	fumarate hydratase activity
O6U12_RS21770	COG1309	transcriptional regulator
O6U12_RS21780	COG2770	Histidine kinase
O6U12_RS21780	COG2205	protein histidine kinase activity
O6U12_RS21785	COG0745	RESPONSE REGULATOR receiver
O6U12_RS21790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O6U12_RS21795	COG0783	Belongs to the Dps family
O6U12_RS21800	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_RS21815	COG1120	ATPase activity
O6U12_RS21825	COG3328	transposase activity
O6U12_RS21830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O6U12_RS21865	COG1942	4-Oxalocrotonate Tautomerase
O6U12_RS21870	COG0477	Major facilitator Superfamily
O6U12_RS21875	COG1846	Transcriptional regulator
O6U12_RS21880	COG5577	PFAM Coat F domain
O6U12_RS21890	COG0506	proline dehydrogenase activity
O6U12_RS21900	COG1250	3-hydroxyacyl-CoA dehydrogenase
O6U12_RS21900	COG1024	Enoyl-CoA hydratase
O6U12_RS21905	COG0183	Belongs to the thiolase family
O6U12_RS21910	COG1960	acyl-CoA dehydrogenase activity
O6U12_RS21915	COG1393	Belongs to the ArsC family
O6U12_RS21920	COG0509	glycine decarboxylation via glycine cleavage system
O6U12_RS21930	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O6U12_RS21935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_RS21945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O6U12_RS21950	COG2011	ABC-type metal ion transport system permease component
O6U12_RS21955	COG1464	Belongs to the NlpA lipoprotein family
O6U12_RS21970	COG0396	ATPase activity
O6U12_RS21975	COG0719	Fe-S assembly protein
O6U12_RS21980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O6U12_RS21985	COG0822	iron-sulfur transferase activity
O6U12_RS21990	COG0719	Fe-S assembly protein
O6U12_RS21995	COG4974	Belongs to the 'phage' integrase family
O6U12_RS22035	COG3646	Phage regulatory protein
O6U12_RS22035	COG3645	SOS response
O6U12_RS22065	COG0305	Participates in initiation and elongation during chromosome replication
O6U12_RS22080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O6U12_RS22095	COG2337	Toxic component of a toxin-antitoxin (TA) module
O6U12_RS22135	COG0740	serine-type endopeptidase activity
O6U12_RS22230	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_RS22230	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_RS22230	COG1388	LysM domain
O6U12_RS22300	COG3883	PFAM NLP P60 protein
O6U12_RS22300	COG0791	NLP P60 protein
O6U12_RS22315	COG3209	COG3209 Rhs family protein
O6U12_RS22365	COG2003	Belongs to the UPF0758 family
O6U12_RS22395	COG1988	membrane-bound metal-dependent
O6U12_RS22410	COG2002	toxin-antitoxin pair type II binding
O6U12_RS22505	COG3764	Sortase (surface protein transpeptidase)
O6U12_RS22540	COG0457	Tetratricopeptide repeat