locus-tag	class	description
HC662_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC662_RS00010	COG0592	DNA-directed DNA polymerase activity
HC662_RS00020	COG2501	S4 domain
HC662_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC662_RS00035	COG0187	DNA topoisomerase II activity
HC662_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC662_RS00080	COG1686	Belongs to the peptidase S11 family
HC662_RS00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HC662_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC662_RS00105	COG1428	Deoxynucleoside kinase
HC662_RS00110	COG1428	Deoxynucleoside kinase
HC662_RS00115	COG1388	LysM domain
HC662_RS00115	COG3858	chitin binding
HC662_RS00120	COG1335	isochorismatase
HC662_RS00125	COG0590	tRNA wobble adenosine to inosine editing
HC662_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HC662_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC662_RS00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC662_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HC662_RS00195	COG3853	Toxic anion resistance protein (TelA)
HC662_RS00200	COG1982	Orn Lys Arg decarboxylase major
HC662_RS00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC662_RS00210	COG3870	Protein conserved in bacteria
HC662_RS00215	COG1728	Protein conserved in bacteria
HC662_RS00220	COG0470	DNA polymerase III
HC662_RS00225	COG1774	PSP1 C-terminal conserved region
HC662_RS00230	COG4467	Involved in initiation control of chromosome replication
HC662_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HC662_RS00240	COG2827	Endonuclease containing a URI domain
HC662_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC662_RS00250	COG2002	toxin-antitoxin pair type II binding
HC662_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_RS00260	COG0084	hydrolase, TatD family'
HC662_RS00265	COG3583	domain protein
HC662_RS00265	COG3584	3D domain protein
HC662_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC662_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC662_RS00285	COG4466	Protein conserved in bacteria
HC662_RS00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC662_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC662_RS00305	COG0251	oxidation-reduction process
HC662_RS00310	COG2088	sporulation resulting in formation of a cellular spore
HC662_RS00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC662_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC662_RS00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HC662_RS00330	COG0193	aminoacyl-tRNA hydrolase activity
HC662_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC662_RS00345	COG2002	toxin-antitoxin pair type II binding
HC662_RS00350	COG2244	polysaccharide biosynthetic process
HC662_RS00355	COG3956	TIGRFAM MazG family protein
HC662_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC662_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HC662_RS00380	COG1098	S1 RNA binding domain
HC662_RS00395	COG2208	phosphoserine phosphatase activity
HC662_RS00400	COG2304	oxidoreductase activity
HC662_RS00405	COG0515	serine threonine protein kinase
HC662_RS00410	COG0037	tRNA processing
HC662_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC662_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HC662_RS00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HC662_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC662_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC662_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC662_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
HC662_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC662_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC662_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC662_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC662_RS00475	COG1396	sequence-specific DNA binding
HC662_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC662_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC662_RS00565	COG4463	regulation of RNA biosynthetic process
HC662_RS00570	COG3880	PFAM UvrB UvrC protein
HC662_RS00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HC662_RS00580	COG0542	response to heat
HC662_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC662_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HC662_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
HC662_RS00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HC662_RS00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HC662_RS00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC662_RS00615	COG1045	serine acetyltransferase
HC662_RS00620	COG0215	cysteine-tRNA ligase activity
HC662_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HC662_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC662_RS00635	COG3688	RNA-binding protein containing a PIN domain
HC662_RS00640	COG1595	DNA-templated transcription, initiation
HC662_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC662_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
HC662_RS00665	COG0081	regulation of translation
HC662_RS00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC662_RS00680	COG2813	Specifically methylates the guanine in position
HC662_RS00685	COG0085	RNA polymerase activity
HC662_RS00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC662_RS00695	COG1358	cellular component organization or biogenesis
HC662_RS00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HC662_RS00705	COG0049	tRNA binding
HC662_RS00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC662_RS00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC662_RS00720	COG0596	Alpha beta hydrolase
HC662_RS00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC662_RS00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC662_RS00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC662_RS00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC662_RS00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC662_RS00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC662_RS00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC662_RS00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC662_RS00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HC662_RS00825	COG0200	Binds to the 23S rRNA
HC662_RS00830	COG0201	protein transport
HC662_RS00835	COG0563	adenylate kinase activity
HC662_RS00840	COG0024	Methionine aminopeptidase
HC662_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC662_RS00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HC662_RS00870	COG0202	RNA polymerase activity
HC662_RS00875	COG0203	ribosomal protein L17
HC662_RS00880	COG1122	ATPase activity
HC662_RS00885	COG1122	ATPase activity
HC662_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC662_RS00895	COG0101	tRNA pseudouridine synthase activity
HC662_RS00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC662_RS00910	COG2226	methyltransferase
HC662_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_RS00925	COG0489	protein tyrosine kinase activity
HC662_RS00935	COG2194	sulfuric ester hydrolase activity
HC662_RS00940	COG0726	polysaccharide deacetylase
HC662_RS01020	COG0738	Major facilitator superfamily
HC662_RS01025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC662_RS01035	COG1063	alcohol dehydrogenase
HC662_RS01040	COG0659	secondary active sulfate transmembrane transporter activity
HC662_RS01045	COG0385	Bile acid
HC662_RS01050	COG2819	hydrolase of the alpha beta superfamily
HC662_RS01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS01060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS01065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_RS01070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_RS01070	COG2207	Transcriptional regulator
HC662_RS01075	COG3876	Protein conserved in bacteria
HC662_RS01080	COG1472	Belongs to the glycosyl hydrolase 3 family
HC662_RS01085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC662_RS01090	COG1263	PTS System
HC662_RS01090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS01095	COG1737	Transcriptional regulator
HC662_RS01100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HC662_RS01110	COG1683	Conserved Protein
HC662_RS01140	COG1595	DNA-templated transcription, initiation
HC662_RS01145	COG5662	AntiSigma factor
HC662_RS01150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC662_RS01155	COG4856	YbbR-like protein
HC662_RS01160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC662_RS01175	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC662_RS01185	COG2169	Transcriptional regulator
HC662_RS01190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC662_RS01195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC662_RS01200	COG3002	Belongs to the UPF0753 family
HC662_RS01205	COG0288	reversible hydration of carbon dioxide
HC662_RS01215	COG5609	conserved protein (DUF2294)
HC662_RS01220	COG0640	Transcriptional regulator
HC662_RS01225	COG2814	Major facilitator Superfamily
HC662_RS01235	COG0596	Alpha beta hydrolase
HC662_RS01240	COG0745	RESPONSE REGULATOR receiver
HC662_RS01245	COG0642	Histidine kinase
HC662_RS01255	COG0515	serine threonine protein kinase
HC662_RS01270	COG1113	amino acid transport
HC662_RS01285	COG2602	Beta-lactamase
HC662_RS01290	COG2124	cytochrome p450
HC662_RS01300	COG0531	amino acid
HC662_RS01305	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC662_RS01310	COG0584	glycerophosphoryl diester phosphodiesterase
HC662_RS01315	COG2271	Major facilitator Superfamily
HC662_RS01325	COG1846	Transcriptional regulator
HC662_RS01325	COG0456	acetyltransferase
HC662_RS01330	COG2271	Major facilitator Superfamily
HC662_RS01335	COG0697	spore germination
HC662_RS01340	COG1917	Cupin 2, conserved barrel domain protein
HC662_RS01340	COG2207	Transcriptional regulator
HC662_RS01345	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HC662_RS01350	COG3591	Belongs to the peptidase S1B family
HC662_RS01360	COG0596	Alpha beta hydrolase
HC662_RS01365	COG1183	phosphatidylcholine synthase activity
HC662_RS01370	COG0586	Pfam SNARE associated Golgi protein
HC662_RS01375	COG0688	phosphatidylethanolamine metabolic process
HC662_RS01385	COG2312	Erythromycin esterase
HC662_RS01390	COG2207	Transcriptional regulator
HC662_RS01400	COG1301	dicarboxylic acid transport
HC662_RS01405	COG2190	(PTS) system
HC662_RS01405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS01405	COG1263	PTS System
HC662_RS01410	COG0363	glucosamine-6-phosphate deaminase activity
HC662_RS01415	COG2188	Transcriptional regulator
HC662_RS01425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC662_RS01430	COG0833	amino acid
HC662_RS01435	COG2040	homocysteine
HC662_RS01440	COG1115	amino acid carrier protein
HC662_RS01445	COG2066	Belongs to the glutaminase family
HC662_RS01450	COG4191	Histidine kinase
HC662_RS01455	COG0784	Response regulator, receiver
HC662_RS01460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC662_RS01465	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS01470	COG2271	Major facilitator Superfamily
HC662_RS01475	COG4948	Mandelate Racemase Muconate Lactonizing
HC662_RS01480	COG2186	Transcriptional regulator
HC662_RS01485	COG2721	sulfolactate sulfo-lyase activity
HC662_RS01490	COG3173	Aminoglycoside phosphotransferase
HC662_RS01500	COG0697	spore germination
HC662_RS01505	COG0745	RESPONSE REGULATOR receiver
HC662_RS01510	COG2205	protein histidine kinase activity
HC662_RS01515	COG1131	(ABC) transporter
HC662_RS01535	COG3773	Cell wall hydrolase
HC662_RS01555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC662_RS01560	COG0805	protein transport
HC662_RS01565	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HC662_RS01570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC662_RS01575	COG0477	Major facilitator Superfamily
HC662_RS01580	COG1309	transcriptional regulator
HC662_RS01585	COG0252	asparaginase activity
HC662_RS01590	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC662_RS01600	COG3012	SEC-C Motif Domain Protein
HC662_RS01600	COG1405	negative regulation of cell septum assembly
HC662_RS01605	COG3290	protein histidine kinase activity
HC662_RS01610	COG3279	Response regulator of the LytR AlgR family
HC662_RS01615	COG4555	ABC transporter
HC662_RS01620	COG1668	transmembrane transport
HC662_RS01625	COG0667	Aldo Keto reductase
HC662_RS01640	COG1595	DNA-templated transcription, initiation
HC662_RS01645	COG1595	DNA-templated transcription, initiation
HC662_RS01650	COG1876	peptidase activity
HC662_RS01655	COG0457	Tetratricopeptide repeat
HC662_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS01665	COG0366	Alpha amylase catalytic
HC662_RS01670	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC662_RS01675	COG1121	(ABC) transporter
HC662_RS01680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC662_RS01685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_RS01690	COG2310	stress, protein
HC662_RS01695	COG2310	stress, protein
HC662_RS01700	COG2310	stress, protein
HC662_RS01705	COG0861	Integral membrane protein TerC family
HC662_RS01715	COG3853	Toxic anion resistance protein (TelA)
HC662_RS01720	COG0477	Major facilitator Superfamily
HC662_RS01725	COG2814	Major facilitator Superfamily
HC662_RS01730	COG0640	Transcriptional regulator
HC662_RS01735	COG0517	IMP dehydrogenase activity
HC662_RS01735	COG4175	Glycine betaine
HC662_RS01740	COG4176	ABC-type proline glycine betaine transport system permease component
HC662_RS01745	COG2113	Glycine betaine
HC662_RS01750	COG1473	amidohydrolase
HC662_RS01755	COG1288	antiporter activity
HC662_RS01765	COG0366	Alpha amylase catalytic
HC662_RS01770	COG0039	L-malate dehydrogenase activity
HC662_RS01775	COG1620	l-lactate permease
HC662_RS01780	COG2814	Major facilitator Superfamily
HC662_RS01785	COG1846	Transcriptional regulator
HC662_RS01790	COG1280	lysine exporter protein (LysE YggA)
HC662_RS01795	COG3403	YqcI/YcgG family
HC662_RS01800	COG1113	amino acid transport
HC662_RS01805	COG3665	Urea carboxylase-associated protein
HC662_RS01810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HC662_RS01815	COG1660	Displays ATPase and GTPase activities
HC662_RS01820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC662_RS01825	COG2226	methyltransferase
HC662_RS01830	COG0583	DNA-binding transcription factor activity
HC662_RS01835	COG3458	cephalosporin-C deacetylase activity
HC662_RS01840	COG3541	Predicted nucleotidyltransferase
HC662_RS01845	COG0506	proline dehydrogenase activity
HC662_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS01855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC662_RS01860	COG2508	Transcriptional regulator
HC662_RS01865	COG3689	TIGRFAM TIGR03943 family protein
HC662_RS01870	COG0701	Predicted permease
HC662_RS01875	COG2267	carboxylic ester hydrolase activity
HC662_RS01880	COG0492	ferredoxin-NADP+ reductase activity
HC662_RS01885	COG1587	Uroporphyrinogen-III synthase
HC662_RS01885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC662_RS01890	COG2146	nitrite reductase [NAD(P)H] activity
HC662_RS01895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC662_RS01900	COG0243	molybdopterin cofactor binding
HC662_RS01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC662_RS01910	COG2223	nitrite transmembrane transporter activity
HC662_RS01915	COG1469	GTP cyclohydrolase I activity
HC662_RS01920	COG1376	ErfK ybiS ycfS ynhG family protein
HC662_RS01930	COG0523	cobalamin synthesis protein
HC662_RS01935	COG0765	amino acid transport
HC662_RS01940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_RS01945	COG1714	RDD family
HC662_RS01955	COG2723	6-phospho-beta-galactosidase activity
HC662_RS01965	COG3209	COG3209 Rhs family protein
HC662_RS01970	COG3290	protein histidine kinase activity
HC662_RS01970	COG0840	transmembrane signaling receptor activity
HC662_RS01975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HC662_RS01980	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HC662_RS01985	COG1733	regulation of RNA biosynthetic process
HC662_RS01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS01995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS02005	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC662_RS02020	COG0697	spore germination
HC662_RS02025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_RS02035	COG2364	Membrane
HC662_RS02040	COG1126	abc transporter atp-binding protein
HC662_RS02045	COG0765	amino acid transport
HC662_RS02050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_RS02055	COG0583	DNA-binding transcription factor activity
HC662_RS02060	COG0163	prenyltransferase activity
HC662_RS02065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC662_RS02080	COG0596	Alpha beta hydrolase
HC662_RS02085	COG3104	oligopeptide transport
HC662_RS02090	COG5434	Belongs to the glycosyl hydrolase 28 family
HC662_RS02110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC662_RS02115	COG1136	(ABC) transporter
HC662_RS02120	COG0577	efflux transmembrane transporter activity
HC662_RS02125	COG0745	RESPONSE REGULATOR receiver
HC662_RS02130	COG3850	Histidine kinase
HC662_RS02130	COG5002	protein histidine kinase activity
HC662_RS02135	COG0457	Tetratricopeptide repeat
HC662_RS02150	COG0527	aspartate kinase activity
HC662_RS02155	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS02160	COG4605	iron ion homeostasis
HC662_RS02165	COG4604	ABC transporter, ATP-binding protein
HC662_RS02170	COG4607	ABC-type enterochelin transport system periplasmic component
HC662_RS02175	COG2814	Major facilitator Superfamily
HC662_RS02180	COG1309	transcriptional regulator
HC662_RS02185	COG0778	Nitroreductase
HC662_RS02190	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC662_RS02195	COG0640	Transcriptional regulator
HC662_RS02200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_RS02205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC662_RS02210	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS02215	COG4975	Glucose uptake
HC662_RS02220	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS02225	COG4549	nuclear export factor GLE1
HC662_RS02230	COG1276	copper resistance
HC662_RS02230	COG2372	response to copper ion
HC662_RS02235	COG1349	DNA-binding transcription factor activity
HC662_RS02245	COG2213	PTS system mannitol-specific
HC662_RS02250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS02255	COG0246	Mannitol dehydrogenase
HC662_RS02260	COG0473	3-isopropylmalate dehydrogenase activity
HC662_RS02265	COG0412	Dienelactone hydrolase
HC662_RS02270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC662_RS02280	COG0561	phosphatase activity
HC662_RS02285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HC662_RS02290	COG1914	H( )-stimulated, divalent metal cation uptake system
HC662_RS02300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC662_RS02305	COG1984	allophanate hydrolase subunit 2
HC662_RS02310	COG1414	Transcriptional regulator
HC662_RS02315	COG2755	lipolytic protein G-D-S-L family
HC662_RS02325	COG2329	Antibiotic biosynthesis monooxygenase
HC662_RS02330	COG0768	penicillin binding
HC662_RS02335	COG4989	oxidoreductase activity
HC662_RS02340	COG3711	transcriptional antiterminator
HC662_RS02345	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_RS02350	COG2226	methyltransferase
HC662_RS02355	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS02360	COG1917	Cupin 2, conserved barrel domain protein
HC662_RS02365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_RS02370	COG3871	stress protein (general stress protein 26)
HC662_RS02380	COG2814	Major facilitator Superfamily
HC662_RS02385	COG1522	sequence-specific DNA binding
HC662_RS02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC662_RS02390	COG0551	DNA topoisomerase type I activity
HC662_RS02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HC662_RS02400	COG3706	GGDEF domain
HC662_RS02405	COG5298	Protein conserved in bacteria
HC662_RS02410	COG1215	transferase activity, transferring glycosyl groups
HC662_RS02420	COG0531	amino acid
HC662_RS02425	COG0494	nUDIX hydrolase
HC662_RS02430	COG0028	Belongs to the TPP enzyme family
HC662_RS02440	COG1914	H( )-stimulated, divalent metal cation uptake system
HC662_RS02445	COG2261	transglycosylase associated protein
HC662_RS02450	COG4876	unkown
HC662_RS02455	COG2217	Heavy metal translocating P-type atpase
HC662_RS02460	COG3729	General stress protein
HC662_RS02465	COG0662	Cupin 2, conserved barrel domain protein
HC662_RS02470	COG2329	Antibiotic biosynthesis monooxygenase
HC662_RS02475	COG3546	catalase activity
HC662_RS02480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HC662_RS02485	COG3290	protein histidine kinase activity
HC662_RS02490	COG4565	transcriptional regulatory protein
HC662_RS02495	COG1301	dicarboxylic acid transport
HC662_RS02500	COG0628	permease
HC662_RS02505	COG1301	dicarboxylic acid transport
HC662_RS02510	COG1131	(ABC) transporter
HC662_RS02515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC662_RS02525	COG1960	acyl-CoA dehydrogenase activity
HC662_RS02540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC662_RS02545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_RS02550	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC662_RS02555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC662_RS02560	COG0513	Belongs to the DEAD box helicase family
HC662_RS02565	COG3402	PFAM membrane-flanked domain
HC662_RS02570	COG3428	Bacterial PH domain
HC662_RS02575	COG0705	Rhomboid family
HC662_RS02580	COG0736	holo-[acyl-carrier-protein] synthase activity
HC662_RS02585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HC662_RS02590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC662_RS02595	COG0864	Transcriptional regulator
HC662_RS02600	COG2337	Toxic component of a toxin-antitoxin (TA) module
HC662_RS02605	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_RS02610	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_RS02615	COG2172	sigma factor antagonist activity
HC662_RS02620	COG2208	phosphoserine phosphatase activity
HC662_RS02625	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_RS02630	COG2172	sigma factor antagonist activity
HC662_RS02635	COG1191	sigma factor activity
HC662_RS02640	COG2208	phosphoserine phosphatase activity
HC662_RS02645	COG2183	response to ionizing radiation
HC662_RS02655	COG3091	SprT-like family
HC662_RS02695	COG0582	viral genome integration into host DNA
HC662_RS02700	COG2856	Zn peptidase
HC662_RS02705	COG1396	sequence-specific DNA binding
HC662_RS02735	COG1674	ftsk spoiiie
HC662_RS02740	COG2946	Replication initiation factor
HC662_RS02785	COG0433	COG0433 Predicted ATPase
HC662_RS02795	COG5644	endopeptidase inhibitor activity
HC662_RS02800	COG0791	NLP P60 protein
HC662_RS02800	COG0741	lytic transglycosylase activity
HC662_RS02840	COG5444	nuclease activity
HC662_RS02845	COG0457	Tetratricopeptide repeat
HC662_RS02865	COG1278	Cold shock
HC662_RS02870	COG1329	Transcriptional regulator
HC662_RS02875	COG3708	Transcriptional regulator
HC662_RS02875	COG2207	Transcriptional regulator
HC662_RS02885	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HC662_RS02890	COG2814	Major facilitator Superfamily
HC662_RS02895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS02900	COG1309	transcriptional regulator
HC662_RS02905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC662_RS02910	COG1522	sequence-specific DNA binding
HC662_RS02925	COG0697	spore germination
HC662_RS02930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_RS02935	COG2030	dehydratase
HC662_RS02940	COG3545	Serine hydrolase
HC662_RS02945	COG1733	regulation of RNA biosynthetic process
HC662_RS02950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_RS02955	COG1733	regulation of RNA biosynthetic process
HC662_RS02960	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC662_RS02965	COG2814	Major facilitator Superfamily
HC662_RS02970	COG1309	transcriptional regulator
HC662_RS02985	COG0640	Transcriptional regulator
HC662_RS02990	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC662_RS02995	COG0640	Transcriptional regulator
HC662_RS03000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC662_RS03005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC662_RS03010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_RS03015	COG1316	TRANSCRIPTIONal
HC662_RS03025	COG3850	Histidine kinase
HC662_RS03025	COG5002	protein histidine kinase activity
HC662_RS03030	COG0745	RESPONSE REGULATOR receiver
HC662_RS03035	COG0697	spore germination
HC662_RS03040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_RS03045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC662_RS03050	COG0640	Transcriptional regulator
HC662_RS03055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC662_RS03070	COG4585	Histidine kinase
HC662_RS03075	COG2197	response regulator
HC662_RS03080	COG2409	Drug exporters of the RND superfamily
HC662_RS03085	COG1811	Na channel or pump
HC662_RS03090	COG4978	Transcriptional regulator
HC662_RS03090	COG0789	Transcriptional regulator
HC662_RS03095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC662_RS03100	COG0778	Nitroreductase
HC662_RS03105	COG0346	lactoylglutathione lyase activity
HC662_RS03110	COG2259	Doxx family
HC662_RS03115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_RS03120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_RS03130	COG1309	transcriptional regulator
HC662_RS03140	COG0456	acetyltransferase
HC662_RS03150	COG1113	amino acid transport
HC662_RS03155	COG2318	DinB family
HC662_RS03160	COG1846	Transcriptional regulator
HC662_RS03165	COG1033	growth of symbiont in host cell
HC662_RS03165	COG2409	Drug exporters of the RND superfamily
HC662_RS03175	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS03180	COG0778	Nitroreductase
HC662_RS03185	COG1846	Transcriptional regulator
HC662_RS03190	COG1396	sequence-specific DNA binding
HC662_RS03205	COG2814	Major facilitator Superfamily
HC662_RS03210	COG0730	response to heat
HC662_RS03215	COG1802	Transcriptional regulator
HC662_RS03220	COG3858	chitin binding
HC662_RS03220	COG1388	LysM domain
HC662_RS03225	COG1819	glycosyl
HC662_RS03235	COG1785	Belongs to the alkaline phosphatase family
HC662_RS03240	COG5646	InterPro IPR014922
HC662_RS03255	COG1078	dGTPase activity
HC662_RS03260	COG1388	LysM domain
HC662_RS03265	COG2814	Major facilitator Superfamily
HC662_RS03270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_RS03275	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC662_RS03280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_RS03285	COG2723	6-phospho-beta-galactosidase activity
HC662_RS03290	COG2188	Transcriptional regulator
HC662_RS03295	COG1940	carbohydrate kinase activity
HC662_RS03300	COG1482	cell wall glycoprotein biosynthetic process
HC662_RS03305	COG4124	Belongs to the glycosyl hydrolase 26 family
HC662_RS03350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HC662_RS03355	COG0802	atpase or kinase
HC662_RS03360	COG1214	PFAM Peptidase M22, glycoprotease
HC662_RS03365	COG0456	acetyltransferase
HC662_RS03370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC662_RS03375	COG0488	(ABC) transporter
HC662_RS03380	COG0315	cyclic pyranopterin monophosphate synthase activity
HC662_RS03385	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HC662_RS03390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC662_RS03395	COG0805	protein transport
HC662_RS03405	COG1266	CAAX protease self-immunity
HC662_RS03415	COG0459	protein refolding
HC662_RS03450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC662_RS03455	COG0457	Tetratricopeptide repeat
HC662_RS03460	COG1063	alcohol dehydrogenase
HC662_RS03465	COG2211	Major facilitator Superfamily
HC662_RS03470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_RS03480	COG2814	Major facilitator Superfamily
HC662_RS03490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC662_RS03495	COG0823	Involved in the tonB-independent uptake of proteins
HC662_RS03505	COG2267	carboxylic ester hydrolase activity
HC662_RS03515	COG2132	Multicopper oxidase
HC662_RS03520	COG1113	amino acid transport
HC662_RS03525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC662_RS03530	COG0714	Associated with various cellular activities
HC662_RS03535	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HC662_RS03540	COG1305	Transglutaminase-like
HC662_RS03545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC662_RS03545	COG0519	Catalyzes the synthesis of GMP from XMP
HC662_RS03565	COG1674	ftsk spoiiie
HC662_RS03605	COG2252	PERMEase
HC662_RS03610	COG3064	Membrane
HC662_RS03620	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HC662_RS03630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC662_RS03635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC662_RS03640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC662_RS03645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC662_RS03650	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC662_RS03655	COG0047	phosphoribosylformylglycinamidine synthase activity
HC662_RS03660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC662_RS03665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC662_RS03670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC662_RS03675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC662_RS03680	COG0138	bifunctional purine biosynthesis protein purh
HC662_RS03685	COG0151	Belongs to the GarS family
HC662_RS03690	COG1522	sequence-specific DNA binding
HC662_RS03695	COG0531	amino acid
HC662_RS03705	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC662_RS03710	COG1470	cell adhesion involved in biofilm formation
HC662_RS03715	COG4496	protein, YerC YecD
HC662_RS03720	COG0069	glutamate synthase activity
HC662_RS03725	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HC662_RS03730	COG0210	DNA helicase
HC662_RS03735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC662_RS03740	COG4851	CamS sex pheromone cAM373 precursor
HC662_RS03745	COG2814	Major facilitator Superfamily
HC662_RS03755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC662_RS03765	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC662_RS03770	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC662_RS03815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC662_RS03820	COG1785	Belongs to the alkaline phosphatase family
HC662_RS03825	COG1285	pathogenesis
HC662_RS03830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC662_RS03835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC662_RS03840	COG0154	amidase activity
HC662_RS03845	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC662_RS03850	COG1309	transcriptional regulator
HC662_RS03855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC662_RS03860	COG1597	lipid kinase activity
HC662_RS03865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC662_RS03895	COG5444	nuclease activity
HC662_RS03900	COG3391	amine dehydrogenase activity
HC662_RS03910	COG0457	Tetratricopeptide repeat
HC662_RS03920	COG0217	transcriptional regulatory protein
HC662_RS03930	COG1309	transcriptional regulator
HC662_RS03935	COG3631	Ketosteroid isomerase-related protein
HC662_RS03940	COG0702	epimerase
HC662_RS03955	COG3546	catalase activity
HC662_RS03960	COG0454	-acetyltransferase
HC662_RS03970	COG5578	integral membrane protein
HC662_RS03975	COG2972	Histidine kinase
HC662_RS03980	COG2207	Transcriptional regulator
HC662_RS03980	COG4753	response regulator
HC662_RS03985	COG1653	transport
HC662_RS03990	COG1175	transmembrane transport
HC662_RS03995	COG0395	ABC-type sugar transport system, permease component
HC662_RS04000	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC662_RS04005	COG2207	Transcriptional regulator
HC662_RS04010	COG2755	lipolytic protein G-D-S-L family
HC662_RS04020	COG5578	integral membrane protein
HC662_RS04025	COG3401	FG-GAP repeat protein
HC662_RS04030	COG3401	FG-GAP repeat protein
HC662_RS04035	COG0667	Aldo Keto reductase
HC662_RS04040	COG2755	lipolytic protein G-D-S-L family
HC662_RS04045	COG1874	Beta-galactosidase
HC662_RS04055	COG1653	transport
HC662_RS04060	COG4209	transmembrane transport
HC662_RS04065	COG0395	ABC-type sugar transport system, permease component
HC662_RS04070	COG1486	melibiose metabolic process
HC662_RS04075	COG2323	membrane
HC662_RS04080	COG2329	Antibiotic biosynthesis monooxygenase
HC662_RS04085	COG0346	lactoylglutathione lyase activity
HC662_RS04100	COG5583	Uncharacterized small protein (DUF2292)
HC662_RS04105	COG0670	Belongs to the BI1 family
HC662_RS04110	COG0697	spore germination
HC662_RS04115	COG1846	Transcriptional regulator
HC662_RS04120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC662_RS04145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC662_RS04145	COG2124	cytochrome p450
HC662_RS04150	COG1368	sulfuric ester hydrolase activity
HC662_RS04155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC662_RS04160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_RS04165	COG1442	glycosyl transferase family 8
HC662_RS04170	COG1216	Glycosyl transferase, family 2
HC662_RS04175	COG1442	glycosyl transferase family 8
HC662_RS04180	COG2223	nitrite transmembrane transporter activity
HC662_RS04185	COG1011	Hydrolase
HC662_RS04190	COG0531	amino acid
HC662_RS04195	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS04200	COG0840	transmembrane signaling receptor activity
HC662_RS04205	COG0488	(ABC) transporter
HC662_RS04215	COG0789	Transcriptional regulator
HC662_RS04220	COG2814	Major facilitator Superfamily
HC662_RS04235	COG0488	(ABC) transporter
HC662_RS04240	COG0513	Belongs to the DEAD box helicase family
HC662_RS04245	COG0456	acetyltransferase
HC662_RS04250	COG2130	NADP-dependent
HC662_RS04255	COG1120	ATPase activity
HC662_RS04260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS04265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS04270	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC662_RS04285	COG3866	Pectate lyase
HC662_RS04290	COG0471	metal ion transport
HC662_RS04295	COG3290	protein histidine kinase activity
HC662_RS04300	COG4565	transcriptional regulatory protein
HC662_RS04305	COG3181	Tripartite tricarboxylate transporter family receptor
HC662_RS04310	COG2851	Citrate transporter
HC662_RS04315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_RS04320	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HC662_RS04325	COG1254	Belongs to the acylphosphatase family
HC662_RS04330	COG2258	MOSC domain
HC662_RS04350	COG0024	Methionine aminopeptidase
HC662_RS04355	COG1263	PTS System
HC662_RS04355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS04360	COG1368	sulfuric ester hydrolase activity
HC662_RS04370	COG1115	amino acid carrier protein
HC662_RS04385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS04385	COG1263	PTS System
HC662_RS04390	COG0366	Alpha amylase catalytic
HC662_RS04395	COG2188	Transcriptional regulator
HC662_RS04400	COG0778	Nitroreductase
HC662_RS04405	COG0737	Belongs to the 5'-nucleotidase family
HC662_RS04410	COG0693	protein deglycase activity
HC662_RS04415	COG2814	Major facilitator Superfamily
HC662_RS04420	COG4840	Belongs to the UPF0435 family
HC662_RS04425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC662_RS04430	COG4980	gas vesicle protein
HC662_RS04435	COG1295	ribonuclease BN
HC662_RS04440	COG0477	Major facilitator Superfamily
HC662_RS04445	COG0387	Pfam Sodium calcium exchanger
HC662_RS04455	COG0668	transmembrane transport
HC662_RS04460	COG0535	radical SAM domain protein
HC662_RS04470	COG0726	polysaccharide deacetylase
HC662_RS04475	COG2084	Dehydrogenase
HC662_RS04480	COG0598	Magnesium transport protein CorA
HC662_RS04485	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC662_RS04490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC662_RS04495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC662_RS04505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HC662_RS04515	COG4637	Psort location Cytoplasmic, score
HC662_RS04525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC662_RS04530	COG0022	dehydrogenase e1 component
HC662_RS04545	COG2259	Doxx family
HC662_RS04550	COG2514	catechol 2,3-dioxygenase activity
HC662_RS04555	COG4585	Histidine kinase
HC662_RS04560	COG2197	response regulator
HC662_RS04565	COG1131	(ABC) transporter
HC662_RS04570	COG0842	Transport permease protein
HC662_RS04570	COG1511	domain protein
HC662_RS04575	COG0842	Transport permease protein
HC662_RS04585	COG1695	Transcriptional regulator
HC662_RS04590	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC662_RS04610	COG1131	(ABC) transporter
HC662_RS04615	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HC662_RS04620	COG1309	transcriptional regulator
HC662_RS04625	COG2814	Major facilitator Superfamily
HC662_RS04630	COG2318	DinB family
HC662_RS04635	COG2814	Major facilitator Superfamily
HC662_RS04640	COG1846	Transcriptional regulator
HC662_RS04645	COG0392	lysyltransferase activity
HC662_RS04645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC662_RS04650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_RS04655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS04660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS04665	COG0384	phenazine biosynthesis protein PhzF
HC662_RS04670	COG0778	Nitroreductase
HC662_RS04685	COG1090	epimerase
HC662_RS04690	COG2137	regulation of response to DNA damage stimulus
HC662_RS04700	COG2814	Major facilitator Superfamily
HC662_RS04715	COG3103	Sh3 type 3 domain protein
HC662_RS04720	COG5658	integral membrane protein
HC662_RS04725	COG0596	Alpha beta hydrolase
HC662_RS04730	COG0463	Glycosyl transferase, family 2
HC662_RS04735	COG4485	Bacterial membrane protein, YfhO
HC662_RS04740	COG1988	membrane-bound metal-dependent
HC662_RS04745	COG1194	a g-specific adenine glycosylase
HC662_RS04755	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS04770	COG3557	Belongs to the UPF0374 family
HC662_RS04775	COG1132	(ABC) transporter
HC662_RS04780	COG4129	membrane
HC662_RS04785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC662_RS04790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC662_RS04795	COG0735	belongs to the Fur family
HC662_RS04915	COG0534	Mate efflux family protein
HC662_RS04920	COG2226	methyltransferase
HC662_RS04930	COG2070	2-Nitropropane dioxygenase
HC662_RS04930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC662_RS04935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_RS04940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_RS04945	COG2226	methyltransferase
HC662_RS04950	COG0534	Mate efflux family protein
HC662_RS05050	COG0735	belongs to the Fur family
HC662_RS05055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC662_RS05065	COG4129	membrane
HC662_RS05070	COG1132	(ABC) transporter
HC662_RS05075	COG3557	Belongs to the UPF0374 family
HC662_RS05095	COG4221	oxidoreductase activity
HC662_RS05095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_RS05095	COG0300	oxidoreductase activity
HC662_RS05095	COG3321	synthase
HC662_RS05100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_RS05100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_RS05100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS05100	COG3321	synthase
HC662_RS05105	COG3321	synthase
HC662_RS05105	COG0300	oxidoreductase activity
HC662_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS05105	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_RS05105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS05110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS05110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_RS05110	COG3321	synthase
HC662_RS05110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_RS05110	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS05115	COG3321	synthase
HC662_RS05115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_RS05115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_RS05115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS05120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC662_RS05130	COG1024	Enoyl-CoA hydratase
HC662_RS05135	COG1024	Enoyl-CoA hydratase
HC662_RS05140	COG1024	Enoyl-CoA hydratase
HC662_RS05150	COG1819	glycosyl
HC662_RS05175	COG4326	sporulation control protein
HC662_RS05185	COG5577	PFAM Coat F domain
HC662_RS05190	COG3340	Belongs to the peptidase S51 family
HC662_RS05195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HC662_RS05205	COG0753	catalase activity
HC662_RS05210	COG1116	anion transmembrane transporter activity
HC662_RS05215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC662_RS05220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC662_RS05225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_RS05235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC662_RS05245	COG1476	TRANSCRIPTIONal
HC662_RS05255	COG3382	B3 4 domain protein
HC662_RS05260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC662_RS05270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC662_RS05275	COG0789	Transcriptional regulator
HC662_RS05280	COG1664	Polymer-forming cytoskeletal
HC662_RS05285	COG1664	Polymer-forming cytoskeletal
HC662_RS05290	COG2766	serine protein kinase
HC662_RS05295	COG2718	Belongs to the UPF0229 family
HC662_RS05300	COG1846	Transcriptional regulator
HC662_RS05305	COG1566	PFAM secretion protein HlyD family protein
HC662_RS05310	COG2814	Major facilitator Superfamily
HC662_RS05315	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC662_RS05335	COG1725	Transcriptional regulator
HC662_RS05340	COG1131	(ABC) transporter
HC662_RS05345	COG1131	(ABC) transporter
HC662_RS05350	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC662_RS05355	COG1278	Cold shock
HC662_RS05360	COG1464	Belongs to the NlpA lipoprotein family
HC662_RS05365	COG3706	GGDEF domain
HC662_RS05370	COG1823	symporter activity
HC662_RS05410	COG5577	PFAM Coat F domain
HC662_RS05420	COG3764	Sortase (surface protein transpeptidase)
HC662_RS05425	COG0564	pseudouridine synthase activity
HC662_RS05435	COG0517	IMP dehydrogenase activity
HC662_RS05440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC662_RS05445	COG3153	acetyltransferase
HC662_RS05445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC662_RS05455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC662_RS05460	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HC662_RS05465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC662_RS05470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC662_RS05480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC662_RS05485	COG4585	Histidine kinase
HC662_RS05485	COG2203	Gaf domain
HC662_RS05490	COG2197	response regulator
HC662_RS05495	COG0431	NADPH-dependent FMN reductase
HC662_RS05510	COG1388	LysM domain
HC662_RS05510	COG0791	NLP P60 protein
HC662_RS05515	COG1959	2 iron, 2 sulfur cluster binding
HC662_RS05520	COG0668	transmembrane transport
HC662_RS05525	COG2719	SpoVR family
HC662_RS05530	COG1785	Belongs to the alkaline phosphatase family
HC662_RS05535	COG0791	NLP P60 protein
HC662_RS05535	COG1388	LysM domain
HC662_RS05540	COG0583	DNA-binding transcription factor activity
HC662_RS05545	COG0372	Belongs to the citrate synthase family
HC662_RS05550	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS05555	COG0531	amino acid
HC662_RS05560	COG0733	neurotransmitter:sodium symporter activity
HC662_RS05565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_RS05570	COG0456	acetyltransferase
HC662_RS05585	COG1595	DNA-templated transcription, initiation
HC662_RS05590	COG0667	Aldo Keto reductase
HC662_RS05595	COG0204	Acyl-transferase
HC662_RS05600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC662_RS05605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_RS05610	COG1253	flavin adenine dinucleotide binding
HC662_RS05615	COG0789	Transcriptional regulator
HC662_RS05620	COG0436	Aminotransferase
HC662_RS05625	COG1253	flavin adenine dinucleotide binding
HC662_RS05630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC662_RS05635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC662_RS05640	COG0584	glycerophosphoryl diester phosphodiesterase
HC662_RS05650	COG0668	transmembrane transport
HC662_RS05655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC662_RS05660	COG0726	polysaccharide deacetylase
HC662_RS05665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC662_RS05670	COG1757	Na H antiporter
HC662_RS05675	COG0589	response to stress
HC662_RS05685	COG1132	(ABC) transporter
HC662_RS05690	COG1132	(ABC) transporter
HC662_RS05695	COG0702	epimerase
HC662_RS05715	COG0189	ligase activity
HC662_RS05720	COG0189	ligase activity
HC662_RS05725	COG4399	Belongs to the UPF0754 family
HC662_RS05730	COG3679	Belongs to the UPF0342 family
HC662_RS05735	COG4335	DNA alkylation repair
HC662_RS05740	COG0561	phosphatase activity
HC662_RS05745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC662_RS05750	COG0475	glutathione-regulated potassium exporter activity
HC662_RS05755	COG0490	domain, Protein
HC662_RS05765	COG1024	Enoyl-CoA hydratase
HC662_RS05775	COG4152	abc transporter atp-binding protein
HC662_RS05780	COG1668	transmembrane transport
HC662_RS05785	COG0420	3'-5' exonuclease activity
HC662_RS05790	COG4717	serine-type aminopeptidase activity
HC662_RS05795	COG3481	metal-dependent phosphohydrolase, HD sub domain
HC662_RS05805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC662_RS05835	COG1846	Transcriptional regulator
HC662_RS05860	COG0537	adenosine 5'-monophosphoramidase activity
HC662_RS05865	COG1131	(ABC) transporter
HC662_RS05870	COG4473	ABC transporter
HC662_RS05880	COG1473	amidohydrolase
HC662_RS05885	COG3069	C4-dicarboxylate transmembrane transporter activity
HC662_RS05895	COG2329	Antibiotic biosynthesis monooxygenase
HC662_RS05900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC662_RS05905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HC662_RS05920	COG1309	transcriptional regulator
HC662_RS05925	COG1511	domain protein
HC662_RS05930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC662_RS05935	COG4377	Putative membrane peptidase family (DUF2324)
HC662_RS05945	COG1363	Peptidase, m42
HC662_RS05950	COG4405	Protein conserved in bacteria
HC662_RS05955	COG1301	dicarboxylic acid transport
HC662_RS05965	COG1234	tRNA 3'-trailer cleavage
HC662_RS05970	COG0095	Lipoate-protein ligase
HC662_RS05975	COG0702	epimerase
HC662_RS05980	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_RS05990	COG0501	Belongs to the peptidase M48B family
HC662_RS05995	COG1404	Belongs to the peptidase S8 family
HC662_RS06000	COG0456	acetyltransferase
HC662_RS06005	COG0604	alcohol dehydrogenase
HC662_RS06010	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC662_RS06015	COG0406	alpha-ribazole phosphatase activity
HC662_RS06020	COG0183	Belongs to the thiolase family
HC662_RS06025	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_RS06030	COG1268	BioY protein
HC662_RS06035	COG0840	transmembrane signaling receptor activity
HC662_RS06040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC662_RS06040	COG0723	plastoquinol--plastocyanin reductase activity
HC662_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS06055	COG4903	ComK protein
HC662_RS06060	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS06070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC662_RS06085	COG0398	Pfam SNARE associated Golgi protein
HC662_RS06090	COG0681	Belongs to the peptidase S26 family
HC662_RS06095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC662_RS06100	COG1846	Transcriptional regulator
HC662_RS06110	COG3180	Ammonia monooxygenase
HC662_RS06115	COG0477	Major facilitator Superfamily
HC662_RS06115	COG2814	Major facilitator Superfamily
HC662_RS06120	COG4533	DNA binding
HC662_RS06130	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HC662_RS06135	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HC662_RS06140	COG1074	ATP-dependent DNA helicase activity
HC662_RS06145	COG0420	3'-5' exonuclease activity
HC662_RS06150	COG0419	ATPase involved in DNA repair
HC662_RS06155	COG1403	HNH endonuclease
HC662_RS06195	COG5337	Spore coat protein CotH
HC662_RS06200	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC662_RS06210	COG1404	Belongs to the peptidase S8 family
HC662_RS06220	COG0367	asparagine synthase
HC662_RS06225	COG1562	ergosterol biosynthetic process
HC662_RS06230	COG0534	Mate efflux family protein
HC662_RS06235	COG1917	Cupin 2, conserved barrel domain protein
HC662_RS06235	COG2207	Transcriptional regulator
HC662_RS06240	COG1609	Transcriptional regulator
HC662_RS06245	COG0673	inositol 2-dehydrogenase activity
HC662_RS06250	COG2318	DinB family
HC662_RS06255	COG1279	arginine transmembrane transporter activity
HC662_RS06260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_RS06265	COG1357	PFAM Pentapeptide repeats (8 copies)
HC662_RS06270	COG2267	carboxylic ester hydrolase activity
HC662_RS06275	COG0529	Catalyzes the synthesis of activated sulfate
HC662_RS06280	COG2046	Belongs to the sulfate adenylyltransferase family
HC662_RS06285	COG0175	sulfate reduction
HC662_RS06290	COG2045	Belongs to the ComB family
HC662_RS06295	COG1809	phosphosulfolactate synthase activity
HC662_RS06300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_RS06305	COG4948	Mandelate Racemase Muconate Lactonizing
HC662_RS06310	COG2814	Major facilitator Superfamily
HC662_RS06315	COG0454	-acetyltransferase
HC662_RS06320	COG2153	protein acetylation
HC662_RS06325	COG0646	methionine synthase
HC662_RS06325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HC662_RS06330	COG1666	GTP binding
HC662_RS06335	COG2996	Protein conserved in bacteria
HC662_RS06355	COG1695	Transcriptional regulator
HC662_RS06370	COG3227	Zinc metalloprotease (Elastase)
HC662_RS06375	COG1307	EDD domain protein, DegV family
HC662_RS06380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_RS06400	COG0561	phosphatase activity
HC662_RS06405	COG1073	alpha beta
HC662_RS06410	COG2151	metal-sulfur cluster biosynthetic enzyme
HC662_RS06420	COG0277	FAD linked oxidase domain protein
HC662_RS06425	COG2271	Major facilitator Superfamily
HC662_RS06430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC662_RS06445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC662_RS06450	COG0505	Belongs to the CarA family
HC662_RS06455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC662_RS06460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HC662_RS06475	COG2267	carboxylic ester hydrolase activity
HC662_RS06485	COG1744	ABC transporter substrate-binding protein PnrA-like
HC662_RS06500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC662_RS06505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC662_RS06510	COG5504	Zn-dependent protease
HC662_RS06515	COG0444	Belongs to the ABC transporter superfamily
HC662_RS06530	COG0601	transmembrane transport
HC662_RS06535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC662_RS06545	COG0180	Tryptophanyl-tRNA synthetase
HC662_RS06550	COG4166	transmembrane transport
HC662_RS06555	COG0601	transmembrane transport
HC662_RS06560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC662_RS06565	COG0444	Belongs to the ABC transporter superfamily
HC662_RS06570	COG4608	Belongs to the ABC transporter superfamily
HC662_RS06575	COG2814	Major facilitator Superfamily
HC662_RS06580	COG0456	acetyltransferase
HC662_RS06585	COG1393	Belongs to the ArsC family
HC662_RS06590	COG0861	Integral membrane protein TerC family
HC662_RS06600	COG4862	establishment of competence for transformation
HC662_RS06605	COG4469	Competence protein
HC662_RS06610	COG1164	Oligoendopeptidase f
HC662_RS06625	COG2346	COG2346, Truncated hemoglobins
HC662_RS06630	COG0741	lytic transglycosylase activity
HC662_RS06635	COG4116	CYTH
HC662_RS06645	COG2357	RelA SpoT domain protein
HC662_RS06650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC662_RS06655	COG0564	pseudouridine synthase activity
HC662_RS06660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC662_RS06665	COG0569	domain protein
HC662_RS06665	COG0475	glutathione-regulated potassium exporter activity
HC662_RS06670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HC662_RS06675	COG0352	thiamine-phosphate diphosphorylase activity
HC662_RS06680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC662_RS06685	COG2104	thiamine diphosphate biosynthetic process
HC662_RS06690	COG2022	thiamine diphosphate biosynthetic process
HC662_RS06695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC662_RS06700	COG0351	phosphomethylpyrimidine kinase
HC662_RS06705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC662_RS06760	COG0210	DNA helicase
HC662_RS06770	COG2153	protein acetylation
HC662_RS06775	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC662_RS06780	COG2382	esterase
HC662_RS06785	COG0626	cystathionine gamma-synthase activity
HC662_RS06790	COG0626	cystathionine gamma-synthase activity
HC662_RS06795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_RS06800	COG5505	Protein of unknown function (DUF819)
HC662_RS06845	COG1595	DNA-templated transcription, initiation
HC662_RS06930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC662_RS06940	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC662_RS06945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS06945	COG3711	transcriptional antiterminator
HC662_RS06950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC662_RS06950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS06950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC662_RS06955	COG1482	cell wall glycoprotein biosynthetic process
HC662_RS06970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_RS06980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC662_RS06990	COG0109	protoheme IX farnesyltransferase activity
HC662_RS07015	COG5504	Zn-dependent protease
HC662_RS07020	COG2205	protein histidine kinase activity
HC662_RS07030	COG3383	formate dehydrogenase (NAD+) activity
HC662_RS07035	COG2427	Protein of unknown function (DUF1641)
HC662_RS07045	COG1051	belongs to the nudix hydrolase family
HC662_RS07055	COG2124	cytochrome p450
HC662_RS07060	COG1819	glycosyl
HC662_RS07070	COG1587	Uroporphyrinogen-III synthase
HC662_RS07080	COG0697	spore germination
HC662_RS07085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC662_RS07095	COG0473	3-isopropylmalate dehydrogenase activity
HC662_RS07095	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HC662_RS07110	COG0390	transport system, permease component
HC662_RS07115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC662_RS07120	COG0697	spore germination
HC662_RS07125	COG4297	protein containing double-stranded beta helix domain
HC662_RS07135	COG1252	NADH dehydrogenase
HC662_RS07140	COG1904	glucuronate isomerase
HC662_RS07145	COG2211	Major facilitator Superfamily
HC662_RS07155	COG1063	alcohol dehydrogenase
HC662_RS07160	COG1312	Catalyzes the dehydration of D-mannonate
HC662_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS07170	COG2271	Major facilitator Superfamily
HC662_RS07175	COG1609	Transcriptional regulator
HC662_RS07180	COG0246	Mannitol dehydrogenase
HC662_RS07185	COG2721	sulfolactate sulfo-lyase activity
HC662_RS07190	COG0730	response to heat
HC662_RS07195	COG2318	DinB family
HC662_RS07200	COG0457	Tetratricopeptide repeat
HC662_RS07210	COG2350	Protein conserved in bacteria
HC662_RS07215	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_RS07215	COG3409	Peptidoglycan-binding domain 1 protein
HC662_RS07215	COG1388	LysM domain
HC662_RS07225	COG4195	phage-related replication protein
HC662_RS07230	COG3546	catalase activity
HC662_RS07235	COG2856	Zn peptidase
HC662_RS07240	COG1396	sequence-specific DNA binding
HC662_RS07250	COG1522	sequence-specific DNA binding
HC662_RS07255	COG1484	DNA-dependent DNA replication
HC662_RS07275	COG1595	DNA-templated transcription, initiation
HC662_RS07280	COG5484	DNA packaging
HC662_RS07280	COG3728	DNA packaging
HC662_RS07285	COG1783	phage Terminase large subunit
HC662_RS07290	COG5518	Phage portal protein
HC662_RS07295	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC662_RS07300	COG4653	Phage capsid family
HC662_RS07350	COG3953	SLT domain
HC662_RS07350	COG5412	phage tail tape measure protein
HC662_RS07355	COG1652	LysM domain
HC662_RS07360	COG4193	domain, Protein
HC662_RS07370	COG3628	GPW Gp25 family protein
HC662_RS07375	COG3299	homolog of phage Mu protein gp47
HC662_RS07380	COG3778	Protein conserved in bacteria
HC662_RS07420	COG3409	Peptidoglycan-binding domain 1 protein
HC662_RS07420	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_RS07440	COG0306	phosphate transporter
HC662_RS07445	COG1392	Phosphate transport regulator
HC662_RS07450	COG0531	amino acid
HC662_RS07455	COG0346	lactoylglutathione lyase activity
HC662_RS07465	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC662_RS07470	COG0463	Glycosyl transferase, family 2
HC662_RS07475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC662_RS07480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC662_RS07485	COG2362	D-Aminopeptidase
HC662_RS07490	COG0601	transmembrane transport
HC662_RS07495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC662_RS07500	COG0444	Belongs to the ABC transporter superfamily
HC662_RS07505	COG4166	transmembrane transport
HC662_RS07510	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC662_RS07515	COG4948	Mandelate Racemase Muconate Lactonizing
HC662_RS07520	COG0791	NLP P60 protein
HC662_RS07525	COG4608	Belongs to the ABC transporter superfamily
HC662_RS07530	COG2706	6-phosphogluconolactonase activity
HC662_RS07535	COG1834	amidinotransferase
HC662_RS07540	COG1607	acyl-coa hydrolase
HC662_RS07545	COG1017	nitric oxide dioxygenase activity
HC662_RS07545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC662_RS07555	COG2323	membrane
HC662_RS07560	COG2318	DinB family
HC662_RS07565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_RS07570	COG2076	Multidrug Resistance protein
HC662_RS07575	COG2076	Multidrug Resistance protein
HC662_RS07580	COG0788	formyltetrahydrofolate deformylase activity
HC662_RS07585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC662_RS07590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HC662_RS07595	COG1764	response to oxidative stress
HC662_RS07600	COG1846	Transcriptional regulator
HC662_RS07605	COG1764	response to oxidative stress
HC662_RS07610	COG0457	Tetratricopeptide repeat
HC662_RS07610	COG0463	Glycosyl transferase, family 2
HC662_RS07615	COG0590	tRNA wobble adenosine to inosine editing
HC662_RS07620	COG0406	alpha-ribazole phosphatase activity
HC662_RS07625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC662_RS07630	COG1404	Belongs to the peptidase S8 family
HC662_RS07635	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_RS07640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC662_RS07645	COG1122	ATPase activity
HC662_RS07650	COG4721	ABC-type cobalt transport system, permease component
HC662_RS07660	COG0745	RESPONSE REGULATOR receiver
HC662_RS07665	COG3850	Histidine kinase
HC662_RS07665	COG5002	protein histidine kinase activity
HC662_RS07670	COG3212	peptidase
HC662_RS07675	COG3212	peptidase
HC662_RS07685	COG2239	Acts as a magnesium transporter
HC662_RS07690	COG0789	Transcriptional regulator
HC662_RS07705	COG1846	Transcriptional regulator
HC662_RS07710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC662_RS07715	COG0726	polysaccharide deacetylase
HC662_RS07720	COG1408	metallophosphoesterase
HC662_RS07730	COG0463	Glycosyl transferase, family 2
HC662_RS07735	COG3285	dna ligase
HC662_RS07735	COG1793	dna ligase
HC662_RS07740	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HC662_RS07745	COG3300	MHYT domain
HC662_RS07745	COG5001	Diguanylate cyclase
HC662_RS07750	COG0586	Pfam SNARE associated Golgi protein
HC662_RS07755	COG0861	Integral membrane protein TerC family
HC662_RS07760	COG1191	sigma factor activity
HC662_RS07780	COG0501	Belongs to the peptidase M48B family
HC662_RS07785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC662_RS07800	COG3594	Acyltransferase
HC662_RS07805	COG5002	protein histidine kinase activity
HC662_RS07810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC662_RS07820	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HC662_RS07825	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HC662_RS07830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC662_RS07835	COG0436	Aminotransferase
HC662_RS07840	COG1850	ribulose-bisphosphate carboxylase activity
HC662_RS07845	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HC662_RS07850	COG0235	Class ii aldolase
HC662_RS07855	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HC662_RS07860	COG3339	Conserved Protein
HC662_RS07875	COG3852	Histidine kinase
HC662_RS07880	COG1846	Transcriptional regulator
HC662_RS07885	COG1360	Flagellar Motor Protein
HC662_RS07890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC662_RS07895	COG0542	response to heat
HC662_RS07900	COG3949	Membrane
HC662_RS07905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HC662_RS07910	COG0720	synthase
HC662_RS07915	COG0602	queuosine metabolic process
HC662_RS07920	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HC662_RS07925	COG1388	LysM domain
HC662_RS07925	COG4641	Protein conserved in bacteria
HC662_RS07930	COG1388	LysM domain
HC662_RS07935	COG3858	chitin binding
HC662_RS07945	COG4873	Protein conserved in bacteria
HC662_RS07955	COG3773	Cell wall hydrolase
HC662_RS07960	COG2244	polysaccharide biosynthetic process
HC662_RS07965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_RS07970	COG2217	Heavy metal translocating P-type atpase
HC662_RS07980	COG0006	proline dipeptidase activity
HC662_RS07985	COG1609	Transcriptional regulator
HC662_RS07990	COG3711	transcriptional antiterminator
HC662_RS07995	COG1263	PTS System
HC662_RS07995	COG2190	(PTS) system
HC662_RS07995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS08000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS08005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC662_RS08015	COG1533	DNA photolyase activity
HC662_RS08020	COG0456	acetyltransferase
HC662_RS08035	COG1609	Transcriptional regulator
HC662_RS08040	COG3711	transcriptional antiterminator
HC662_RS08045	COG1263	PTS System
HC662_RS08045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS08045	COG2190	(PTS) system
HC662_RS08050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS08055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC662_RS08065	COG1533	DNA photolyase activity
HC662_RS08070	COG0456	acetyltransferase
HC662_RS08075	COG0840	transmembrane signaling receptor activity
HC662_RS08080	COG2084	Dehydrogenase
HC662_RS08085	COG4257	antibiotic catabolic process
HC662_RS08090	COG2340	Cysteine-rich secretory protein family
HC662_RS08095	COG0768	penicillin binding
HC662_RS08100	COG4191	Histidine kinase
HC662_RS08105	COG0436	Aminotransferase
HC662_RS08115	COG0835	chemotaxis
HC662_RS08115	COG0784	Response regulator, receiver
HC662_RS08125	COG2814	Major facilitator Superfamily
HC662_RS08130	COG1376	ErfK ybiS ycfS ynhG family protein
HC662_RS08135	COG1408	metallophosphoesterase
HC662_RS08140	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS08145	COG2200	EAL domain
HC662_RS08150	COG4703	Protein of unknown function (DUF1797)
HC662_RS08155	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HC662_RS08165	COG0517	IMP dehydrogenase activity
HC662_RS08170	COG0583	DNA-binding transcription factor activity
HC662_RS08175	COG0716	FMN binding
HC662_RS08185	COG0716	FMN binding
HC662_RS08190	COG2171	N-acyltransferase activity
HC662_RS08195	COG1473	amidohydrolase
HC662_RS08205	COG0668	transmembrane transport
HC662_RS08210	COG0450	alkyl hydroperoxide reductase
HC662_RS08215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_RS08230	COG0746	molybdenum cofactor guanylyltransferase activity
HC662_RS08235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC662_RS08240	COG0303	'Molybdopterin
HC662_RS08245	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC662_RS08250	COG0314	molybdopterin synthase activity
HC662_RS08255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HC662_RS08260	COG1132	(ABC) transporter
HC662_RS08265	COG1132	(ABC) transporter
HC662_RS08275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC662_RS08280	COG1136	(ABC) transporter
HC662_RS08285	COG0577	efflux transmembrane transporter activity
HC662_RS08290	COG1349	DNA-binding transcription factor activity
HC662_RS08295	COG1105	Belongs to the carbohydrate kinase PfkB family
HC662_RS08300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC662_RS08300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC662_RS08300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS08305	COG0681	Belongs to the peptidase S26 family
HC662_RS08315	COG0488	(ABC) transporter
HC662_RS08320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC662_RS08325	COG2309	aminopeptidase activity
HC662_RS08335	COG1077	Cell shape determining protein MreB Mrl
HC662_RS08340	COG2002	toxin-antitoxin pair type II binding
HC662_RS08345	COG3852	Histidine kinase
HC662_RS08350	COG2105	PFAM AIG2 family protein
HC662_RS08350	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HC662_RS08355	COG0569	domain protein
HC662_RS08360	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC662_RS08365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC662_RS08375	COG0561	phosphatase activity
HC662_RS08380	COG0242	peptide deformylase activity
HC662_RS08390	COG0497	DNA recombination
HC662_RS08395	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC662_RS08400	COG0022	dehydrogenase e1 component
HC662_RS08405	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC662_RS08410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC662_RS08415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_RS08425	COG1982	Orn Lys Arg decarboxylase major
HC662_RS08430	COG4476	Belongs to the UPF0223 family
HC662_RS08435	COG4493	Belongs to the UPF0637 family
HC662_RS08445	COG0483	inositol monophosphate 1-phosphatase activity
HC662_RS08455	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HC662_RS08465	COG1959	2 iron, 2 sulfur cluster binding
HC662_RS08485	COG1595	DNA-templated transcription, initiation
HC662_RS08515	COG4896	Protein conserved in bacteria
HC662_RS08525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HC662_RS08530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC662_RS08535	COG2066	Belongs to the glutaminase family
HC662_RS08540	COG4838	Belongs to the UPF0358 family
HC662_RS08545	COG0772	Belongs to the SEDS family
HC662_RS08550	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HC662_RS08560	COG0109	protoheme IX farnesyltransferase activity
HC662_RS08565	COG2010	Cytochrome c
HC662_RS08565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC662_RS08570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC662_RS08575	COG1845	cytochrome c oxidase, subunit III
HC662_RS08580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC662_RS08585	COG3336	cytochrome c oxidase
HC662_RS08595	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HC662_RS08600	COG2340	Cysteine-rich secretory protein family
HC662_RS08615	COG3679	Belongs to the UPF0342 family
HC662_RS08620	COG4471	UPF0298 protein
HC662_RS08625	COG0742	ribosomal rna small subunit methyltransferase
HC662_RS08630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC662_RS08635	COG3314	Sporulation integral membrane protein YlbJ
HC662_RS08640	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC662_RS08645	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC662_RS08650	COG1323	Belongs to the UPF0348 family
HC662_RS08660	COG1399	metal-binding, possibly nucleic acid-binding protein
HC662_RS08675	COG0454	-acetyltransferase
HC662_RS08680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC662_RS08685	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HC662_RS08695	COG0275	rRNA processing
HC662_RS08700	COG4839	cell division protein FtsL
HC662_RS08710	COG0768	penicillin binding
HC662_RS08715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC662_RS08720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC662_RS08725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC662_RS08730	COG0772	Belongs to the SEDS family
HC662_RS08735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC662_RS08740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC662_RS08745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HC662_RS08750	COG3879	Bacterial protein of unknown function (DUF881)
HC662_RS08755	COG3879	Bacterial protein of unknown function (DUF881)
HC662_RS08760	COG3856	small basic protein
HC662_RS08765	COG0849	cell division
HC662_RS08770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC662_RS08775	COG1404	Belongs to the peptidase S8 family
HC662_RS08775	COG4412	M6 family metalloprotease domain protein
HC662_RS08785	COG1191	sigma factor activity
HC662_RS08790	COG1191	sigma factor activity
HC662_RS08795	COG1119	ATPase activity
HC662_RS08800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC662_RS08805	COG1873	PFAM PRC-barrel domain
HC662_RS08815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC662_RS08820	COG1799	cell septum assembly
HC662_RS08825	COG0762	integral membrane protein
HC662_RS08830	COG2302	S4 RNA-binding domain
HC662_RS08835	COG3599	regulation of cell shape
HC662_RS08840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC662_RS08845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC662_RS08850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC662_RS08855	COG0564	pseudouridine synthase activity
HC662_RS08860	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HC662_RS08865	COG2233	PERMEase
HC662_RS08870	COG0540	Belongs to the ATCase OTCase family
HC662_RS08875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC662_RS08880	COG0505	Belongs to the CarA family
HC662_RS08885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC662_RS08890	COG0543	2 iron, 2 sulfur cluster binding
HC662_RS08895	COG0167	dihydroorotate dehydrogenase activity
HC662_RS08900	COG0284	orotidine-5'-phosphate decarboxylase activity
HC662_RS08905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC662_RS08910	COG0175	sulfate reduction
HC662_RS08915	COG0306	phosphate transporter
HC662_RS08920	COG2046	Belongs to the sulfate adenylyltransferase family
HC662_RS08925	COG0529	Catalyzes the synthesis of activated sulfate
HC662_RS08930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC662_RS08935	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HC662_RS08940	COG1648	precorrin-2 dehydrogenase activity
HC662_RS08945	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HC662_RS08950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC662_RS08955	COG1561	YicC-like family, N-terminal region
HC662_RS08965	COG0194	GDP metabolic process
HC662_RS08970	COG1758	RNA polymerase activity
HC662_RS08975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC662_RS08980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC662_RS08985	COG0242	peptide deformylase activity
HC662_RS08990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC662_RS08995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HC662_RS08995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC662_RS09000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC662_RS09005	COG0631	protein serine/threonine phosphatase activity
HC662_RS09010	COG0515	serine threonine protein kinase
HC662_RS09010	COG2815	serine threonine protein kinase
HC662_RS09015	COG1162	GTPase activity
HC662_RS09020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC662_RS09025	COG1564	THIamine pyrophosphokinase
HC662_RS09035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC662_RS09040	COG1302	Protein conserved in bacteria
HC662_RS09045	COG1461	Dihydroxyacetone kinase
HC662_RS09050	COG1760	l-serine dehydratase
HC662_RS09055	COG1760	l-serine dehydratase
HC662_RS09060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC662_RS09065	COG1349	DNA-binding transcription factor activity
HC662_RS09065	COG2050	protein possibly involved in aromatic compounds catabolism
HC662_RS09070	COG0416	fatty acid biosynthetic process
HC662_RS09075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC662_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS09090	COG0571	ribonuclease III activity
HC662_RS09095	COG1196	nuclear chromosome segregation
HC662_RS09100	COG0552	protein localization to endoplasmic reticulum
HC662_RS09110	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HC662_RS09115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC662_RS09120	COG0228	four-way junction DNA binding
HC662_RS09125	COG1837	Belongs to the UPF0109 family
HC662_RS09135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC662_RS09140	COG0336	Belongs to the RNA methyltransferase TrmD family
HC662_RS09145	COG0335	large ribosomal subunit rRNA binding
HC662_RS09150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC662_RS09155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC662_RS09165	COG2257	FlhB HrpN YscU SpaS Family
HC662_RS09170	COG0045	succinate-CoA ligase (ADP-forming) activity
HC662_RS09175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC662_RS09180	COG0758	DNA mediated transformation
HC662_RS09185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC662_RS09190	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HC662_RS09195	COG4974	Belongs to the 'phage' integrase family
HC662_RS09200	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HC662_RS09205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HC662_RS09210	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC662_RS09215	COG1815	bacterial-type flagellum-dependent cell motility
HC662_RS09220	COG1558	bacterial-type flagellum-dependent cell motility
HC662_RS09225	COG1677	Flagellar hook-basal body complex protein FliE
HC662_RS09230	COG1766	The M ring may be actively involved in energy transduction
HC662_RS09235	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC662_RS09240	COG1317	bacterial-type flagellum organization
HC662_RS09245	COG1157	protein secretion by the type III secretion system
HC662_RS09250	COG2882	bacterial-type flagellum organization
HC662_RS09255	COG3334	PFAM MgtE intracellular
HC662_RS09260	COG3144	bacterial-type flagellum assembly
HC662_RS09265	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HC662_RS09270	COG4786	Flagellar basal body rod
HC662_RS09275	COG1582	Flagellar protein (FlbD)
HC662_RS09280	COG1580	Controls the rotational direction of flagella during chemotaxis
HC662_RS09285	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC662_RS09290	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC662_RS09290	COG1776	CheC inhibitor of MCP methylation
HC662_RS09295	COG2201	protein-glutamate methylesterase activity
HC662_RS09300	COG3190	flagellar
HC662_RS09305	COG1338	Plays a role in the flagellum-specific transport system
HC662_RS09310	COG1987	bacterial-type flagellum assembly
HC662_RS09315	COG1684	flagellar biosynthetic protein fliR
HC662_RS09320	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC662_RS09325	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC662_RS09330	COG1419	protein localization to endoplasmic reticulum
HC662_RS09335	COG0455	bacterial-type flagellum organization
HC662_RS09340	COG2201	protein-glutamate methylesterase activity
HC662_RS09345	COG0643	Histidine kinase
HC662_RS09345	COG2198	Histidine kinase
HC662_RS09350	COG0835	chemotaxis
HC662_RS09355	COG1776	CheC inhibitor of MCP methylation
HC662_RS09360	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HC662_RS09365	COG1191	sigma factor activity
HC662_RS09375	COG0052	Belongs to the universal ribosomal protein uS2 family
HC662_RS09380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC662_RS09385	COG0528	UMP kinase activity
HC662_RS09390	COG0233	cytoplasmic translational termination
HC662_RS09395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC662_RS09400	COG4589	Belongs to the CDS family
HC662_RS09405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC662_RS09410	COG0750	zinc metalloprotease
HC662_RS09415	COG0442	prolyl-tRNA aminoacylation
HC662_RS09420	COG2176	DNA-directed DNA polymerase activity
HC662_RS09425	COG0779	Required for maturation of 30S ribosomal subunits
HC662_RS09430	COG0195	Participates in both transcription termination and antitermination
HC662_RS09435	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HC662_RS09440	COG1358	cellular component organization or biogenesis
HC662_RS09445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HC662_RS09450	COG1550	Protein conserved in bacteria
HC662_RS09455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC662_RS09460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC662_RS09465	COG0196	riboflavin kinase activity
HC662_RS09475	COG1185	polyribonucleotide nucleotidyltransferase activity
HC662_RS09480	COG0726	polysaccharide deacetylase
HC662_RS09485	COG0612	Peptidase, M16
HC662_RS09490	COG1873	PFAM PRC-barrel domain
HC662_RS09495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC662_RS09500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC662_RS09505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC662_RS09510	COG0527	aspartate kinase activity
HC662_RS09515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC662_RS09520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC662_RS09525	COG0740	serine-type endopeptidase activity
HC662_RS09535	COG1674	ftsk spoiiie
HC662_RS09535	COG4980	gas vesicle protein
HC662_RS09545	COG1418	mRNA catabolic process
HC662_RS09550	COG1692	metallophosphoesterase
HC662_RS09555	COG2359	stage V sporulation protein S
HC662_RS09560	COG1063	alcohol dehydrogenase
HC662_RS09565	COG0156	8-amino-7-oxononanoate synthase activity
HC662_RS09570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC662_RS09575	COG4550	Control of competence regulator ComK, YlbF/YmcA
HC662_RS09585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC662_RS09590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HC662_RS09625	COG3226	Transcriptional regulator
HC662_RS09635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_RS09640	COG1404	Belongs to the peptidase S8 family
HC662_RS09650	COG4195	phage-related replication protein
HC662_RS09655	COG1764	response to oxidative stress
HC662_RS09680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC662_RS09685	COG1923	regulation of RNA biosynthetic process
HC662_RS09700	COG1780	Probably involved in ribonucleotide reductase function
HC662_RS09705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC662_RS09710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC662_RS09715	COG4112	unkown
HC662_RS09720	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_RS09725	COG0464	growth
HC662_RS09730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC662_RS09735	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HC662_RS09740	COG0789	Transcriptional regulator
HC662_RS09745	COG0174	glutamine synthetase
HC662_RS09760	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC662_RS09765	COG1733	regulation of RNA biosynthetic process
HC662_RS09800	COG0135	phosphoribosylanthranilate isomerase activity
HC662_RS09830	COG2211	Major facilitator Superfamily
HC662_RS09835	COG3507	Belongs to the glycosyl hydrolase 43 family
HC662_RS09850	COG1070	Carbohydrate kinase
HC662_RS09925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC662_RS09935	COG3832	glyoxalase III activity
HC662_RS09950	COG2059	Chromate
HC662_RS09955	COG0697	spore germination
HC662_RS09960	COG0531	amino acid
HC662_RS09990	COG4195	phage-related replication protein
HC662_RS10000	COG0346	lactoylglutathione lyase activity
HC662_RS10010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC662_RS10020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC662_RS10025	COG4224	UPF0291 protein
HC662_RS10030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC662_RS10040	COG3763	UPF0154 protein
HC662_RS10050	COG0785	Cytochrome C biogenesis protein
HC662_RS10055	COG2201	protein-glutamate methylesterase activity
HC662_RS10060	COG4846	Membrane protein involved in cytochrome C biogenesis
HC662_RS10070	COG0071	Belongs to the small heat shock protein (HSP20) family
HC662_RS10085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC662_RS10090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_RS10110	COG0824	Thioesterase
HC662_RS10120	COG4841	protein insertion into membrane
HC662_RS10125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HC662_RS10130	COG1832	CoA-binding protein
HC662_RS10135	COG0187	DNA topoisomerase II activity
HC662_RS10140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC662_RS10150	COG1115	amino acid carrier protein
HC662_RS10155	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HC662_RS10165	COG5520	Belongs to the glycosyl hydrolase 30 family
HC662_RS10170	COG3507	Belongs to the glycosyl hydrolase 43 family
HC662_RS10200	COG2246	polysaccharide biosynthetic process
HC662_RS10205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC662_RS10210	COG0586	Pfam SNARE associated Golgi protein
HC662_RS10215	COG2404	hydrolase activity, acting on ester bonds
HC662_RS10220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC662_RS10225	COG1024	Enoyl-CoA hydratase
HC662_RS10230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC662_RS10235	COG0511	ligase activity, forming carbon-carbon bonds
HC662_RS10240	COG0439	Biotin carboxylase
HC662_RS10245	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_RS10250	COG1960	acyl-CoA dehydrogenase activity
HC662_RS10270	COG1649	PFAM Uncharacterised BCR, COG1649
HC662_RS10280	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC662_RS10280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS10285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS10290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS10295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS10300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS10305	COG2027	D-alanyl-D-alanine carboxypeptidase
HC662_RS10310	COG2017	converts alpha-aldose to the beta-anomer
HC662_RS10315	COG0534	Mate efflux family protein
HC662_RS10330	COG0582	viral genome integration into host DNA
HC662_RS10335	COG0166	Belongs to the GPI family
HC662_RS10340	COG0405	Gamma-glutamyltransferase
HC662_RS10345	COG0583	DNA-binding transcription factor activity
HC662_RS10350	COG0604	alcohol dehydrogenase
HC662_RS10355	COG0493	'glutamate synthase
HC662_RS10360	COG0070	glutamate synthase
HC662_RS10360	COG0069	glutamate synthase activity
HC662_RS10360	COG0067	glutamate synthase
HC662_RS10365	COG0583	DNA-binding transcription factor activity
HC662_RS10370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC662_RS10385	COG0300	oxidoreductase activity
HC662_RS10390	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC662_RS10400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_RS10405	COG2814	Major facilitator Superfamily
HC662_RS10410	COG1070	Carbohydrate kinase
HC662_RS10415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC662_RS10420	COG0243	molybdopterin cofactor binding
HC662_RS10430	COG2814	Major facilitator Superfamily
HC662_RS10435	COG0673	inositol 2-dehydrogenase activity
HC662_RS10440	COG1082	Xylose isomerase domain protein TIM barrel
HC662_RS10445	COG1609	Transcriptional regulator
HC662_RS10465	COG0840	transmembrane signaling receptor activity
HC662_RS10465	COG5278	phosphoserine phosphatase activity
HC662_RS10470	COG2368	4-hydroxyphenylacetate
HC662_RS10475	COG4305	rare lipoprotein A
HC662_RS10480	COG3619	membrane
HC662_RS10490	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS10505	COG2135	peptidase activity
HC662_RS10525	COG0457	Tetratricopeptide repeat
HC662_RS10550	COG2720	vancomycin resistance protein
HC662_RS10565	COG3739	integral membrane protein
HC662_RS10570	COG0583	DNA-binding transcription factor activity
HC662_RS10575	COG0697	spore germination
HC662_RS10580	COG1388	LysM domain
HC662_RS10590	COG0693	protein deglycase activity
HC662_RS10595	COG2367	Beta-lactamase
HC662_RS10605	COG3397	chitin binding
HC662_RS10610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_RS10615	COG3848	Pyruvate phosphate dikinase
HC662_RS10615	COG0574	Belongs to the PEP-utilizing enzyme family
HC662_RS10625	COG4282	regulation of fungal-type cell wall biogenesis
HC662_RS10630	COG1231	oxidoreductase activity
HC662_RS10640	COG0726	polysaccharide deacetylase
HC662_RS10655	COG0582	viral genome integration into host DNA
HC662_RS10755	COG3655	Transcriptional regulator
HC662_RS10780	COG1404	Belongs to the peptidase S8 family
HC662_RS10780	COG4935	Belongs to the peptidase S8 family
HC662_RS10800	COG0457	Tetratricopeptide repeat
HC662_RS10810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC662_RS10815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC662_RS10835	COG4935	Belongs to the peptidase S8 family
HC662_RS10835	COG1404	Belongs to the peptidase S8 family
HC662_RS10855	COG5444	nuclease activity
HC662_RS10860	COG4282	regulation of fungal-type cell wall biogenesis
HC662_RS10870	COG1525	nuclease
HC662_RS10910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_RS10915	COG0662	Cupin 2, conserved barrel domain protein
HC662_RS10915	COG2207	Transcriptional regulator
HC662_RS10920	COG0456	acetyltransferase
HC662_RS10925	COG1309	transcriptional regulator
HC662_RS10930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_RS10935	COG3708	Transcriptional regulator
HC662_RS10940	COG2378	regulation of single-species biofilm formation
HC662_RS10950	COG0640	Transcriptional regulator
HC662_RS10955	COG0741	lytic transglycosylase activity
HC662_RS10960	COG2322	membrane
HC662_RS10975	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC662_RS10980	COG3239	Fatty acid desaturase
HC662_RS10985	COG4585	Histidine kinase
HC662_RS10990	COG2197	response regulator
HC662_RS11000	COG1388	LysM domain
HC662_RS11000	COG3584	3D domain protein
HC662_RS11005	COG0514	ATP-dependent DNA helicase (RecQ)
HC662_RS11015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC662_RS11020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC662_RS11035	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS11040	COG1657	PFAM Prenyltransferase squalene oxidase
HC662_RS11045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC662_RS11050	COG0733	neurotransmitter:sodium symporter activity
HC662_RS11055	COG0385	Bile acid
HC662_RS11060	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC662_RS11065	COG0567	Dehydrogenase, E1 component
HC662_RS11070	COG4548	von Willebrand factor, type A
HC662_RS11075	COG0714	Associated with various cellular activities
HC662_RS11080	COG2032	superoxide dismutase activity
HC662_RS11085	COG1388	LysM domain
HC662_RS11085	COG0791	NLP P60 protein
HC662_RS11090	COG1819	glycosyl
HC662_RS11095	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC662_RS11100	COG0534	Mate efflux family protein
HC662_RS11105	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_RS11110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC662_RS11115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC662_RS11125	COG2962	Rard protein
HC662_RS11140	COG2610	gluconate transmembrane transporter activity
HC662_RS11145	COG1942	4-Oxalocrotonate Tautomerase
HC662_RS11150	COG1733	regulation of RNA biosynthetic process
HC662_RS11155	COG0778	Nitroreductase
HC662_RS11160	COG0400	carboxylic ester hydrolase activity
HC662_RS11165	COG0346	lactoylglutathione lyase activity
HC662_RS11175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC662_RS11180	COG3409	Peptidoglycan-binding domain 1 protein
HC662_RS11180	COG0793	Belongs to the peptidase S41A family
HC662_RS11185	COG2226	methyltransferase
HC662_RS11195	COG1876	peptidase activity
HC662_RS11200	COG0813	purine-nucleoside phosphorylase activity
HC662_RS11215	COG0671	phosphoesterase, PA-phosphatase related
HC662_RS11235	COG4479	Belongs to the UPF0346 family
HC662_RS11245	COG1509	lysine 2,3-aminomutase activity
HC662_RS11250	COG0456	acetyltransferase
HC662_RS11255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC662_RS11260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC662_RS11265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC662_RS11270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC662_RS11285	COG0456	acetyltransferase
HC662_RS11290	COG0463	Glycosyl transferase, family 2
HC662_RS11305	COG4641	Protein conserved in bacteria
HC662_RS11310	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HC662_RS11315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC662_RS11330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC662_RS11335	COG1846	Transcriptional regulator
HC662_RS11340	COG0534	Mate efflux family protein
HC662_RS11350	COG4698	Protein conserved in bacteria
HC662_RS11355	COG2755	lipolytic protein G-D-S-L family
HC662_RS11360	COG1999	signal sequence binding
HC662_RS11370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC662_RS11375	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC662_RS11380	COG1272	protein, Hemolysin III
HC662_RS11385	COG0204	Acyl-transferase
HC662_RS11390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC662_RS11400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC662_RS11410	COG2136	Putative SAM-dependent methyltransferase
HC662_RS11410	COG2521	methyltransferase
HC662_RS11420	COG0129	dihydroxy-acid dehydratase activity
HC662_RS11425	COG1413	lyase activity
HC662_RS11430	COG1418	mRNA catabolic process
HC662_RS11435	COG0386	Belongs to the glutathione peroxidase family
HC662_RS11440	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HC662_RS11455	COG1278	Cold shock
HC662_RS11475	COG0328	RNA-DNA hybrid ribonuclease activity
HC662_RS11480	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HC662_RS11485	COG0328	RNA-DNA hybrid ribonuclease activity
HC662_RS11495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC662_RS11510	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC662_RS11520	COG1755	Isoprenylcysteine carboxyl methyltransferase
HC662_RS11525	COG3424	synthase
HC662_RS11530	COG2233	PERMEase
HC662_RS11535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC662_RS11540	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC662_RS11550	COG0800	Aldolase
HC662_RS11555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_RS11560	COG1609	Transcriptional regulator
HC662_RS11565	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HC662_RS11570	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS11580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC662_RS11585	COG3935	DnaD domain protein
HC662_RS11590	COG0017	Asparaginyl-tRNA synthetase
HC662_RS11595	COG0436	Aminotransferase
HC662_RS11600	COG5353	protein conserved in bacteria
HC662_RS11610	COG1199	ATP-dependent helicase activity
HC662_RS11610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC662_RS11615	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HC662_RS11620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HC662_RS11625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HC662_RS11630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HC662_RS11630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HC662_RS11635	COG0617	tRNA 3'-terminal CCA addition
HC662_RS11640	COG0438	transferase activity, transferring glycosyl groups
HC662_RS11645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC662_RS11650	COG1803	Methylglyoxal synthase
HC662_RS11655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HC662_RS11660	COG1694	Mazg nucleotide pyrophosphohydrolase
HC662_RS11665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_RS11675	COG4347	Protein of unknown function (DUF1405)
HC662_RS11680	COG2010	Cytochrome c
HC662_RS11680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC662_RS11685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC662_RS11690	COG0723	plastoquinol--plastocyanin reductase activity
HC662_RS11700	COG5582	Belongs to the UPF0302 family
HC662_RS11705	COG0457	Tetratricopeptide repeat
HC662_RS11710	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC662_RS11715	COG0287	Prephenate dehydrogenase
HC662_RS11720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC662_RS11725	COG0159	tryptophan synthase activity
HC662_RS11730	COG0133	tryptophan synthase activity
HC662_RS11735	COG0135	phosphoribosylanthranilate isomerase activity
HC662_RS11745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC662_RS11750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC662_RS11755	COG4401	Chorismate mutase type I
HC662_RS11760	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HC662_RS11765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC662_RS11770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HC662_RS11775	COG0105	UTP biosynthetic process
HC662_RS11780	COG0142	geranyltranstransferase activity
HC662_RS11785	COG2226	methyltransferase
HC662_RS11790	COG0142	geranyltranstransferase activity
HC662_RS11800	COG0302	gtp cyclohydrolase
HC662_RS11805	COG0776	regulation of translation
HC662_RS11810	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC662_RS11825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC662_RS11830	COG1160	GTP binding
HC662_RS11855	COG1304	FMN binding
HC662_RS11860	COG0539	negative regulation of cytoplasmic translation
HC662_RS11865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC662_RS11875	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HC662_RS11880	COG2959	enzyme of heme biosynthesis
HC662_RS11885	COG3773	Cell wall hydrolase
HC662_RS11885	COG3409	Peptidoglycan-binding domain 1 protein
HC662_RS11890	COG2339	peptidase activity
HC662_RS11895	COG0492	ferredoxin-NADP+ reductase activity
HC662_RS11900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC662_RS11905	COG4862	establishment of competence for transformation
HC662_RS11910	COG1408	metallophosphoesterase
HC662_RS11925	COG1266	CAAX protease self-immunity
HC662_RS11930	COG0514	ATP-dependent DNA helicase (RecQ)
HC662_RS11935	COG4955	Helix-turn-helix domain
HC662_RS11940	COG1141	Ferredoxin
HC662_RS11945	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HC662_RS11950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC662_RS11955	COG0710	3-dehydroquinate dehydratase activity
HC662_RS11965	COG1595	DNA-templated transcription, initiation
HC662_RS11970	COG5002	protein histidine kinase activity
HC662_RS11975	COG0745	RESPONSE REGULATOR receiver
HC662_RS11980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC662_RS11985	COG1333	cytochrome c biogenesis protein
HC662_RS11990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_RS11995	COG1187	pseudouridine synthase activity
HC662_RS12000	COG0700	Nucleoside recognition
HC662_RS12005	COG2715	membrane protein required for spore maturation
HC662_RS12010	COG1686	Belongs to the peptidase S11 family
HC662_RS12025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HC662_RS12030	COG1547	Domain of unknown function (DUF309)
HC662_RS12035	COG0456	acetyltransferase
HC662_RS12040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HC662_RS12045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC662_RS12045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC662_RS12050	COG0307	riboflavin synthase, alpha
HC662_RS12065	COG0681	Belongs to the peptidase S26 family
HC662_RS12070	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HC662_RS12080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC662_RS12085	COG4086	secreted protein
HC662_RS12090	COG0019	diaminopimelate decarboxylase activity
HC662_RS12095	COG0697	spore germination
HC662_RS12110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC662_RS12130	COG1191	sigma factor activity
HC662_RS12140	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_RS12145	COG1686	Belongs to the peptidase S11 family
HC662_RS12150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HC662_RS12155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HC662_RS12160	COG4974	Belongs to the 'phage' integrase family
HC662_RS12170	COG0735	belongs to the Fur family
HC662_RS12175	COG1300	Membrane
HC662_RS12185	COG0281	malic enzyme
HC662_RS12190	COG1757	Na H antiporter
HC662_RS12195	COG1027	Aspartate ammonia-lyase
HC662_RS12200	COG0252	asparaginase activity
HC662_RS12205	COG1396	sequence-specific DNA binding
HC662_RS12210	COG1379	DNA repair
HC662_RS12215	COG0494	nUDIX hydrolase
HC662_RS12225	COG0667	Aldo Keto reductase
HC662_RS12235	COG1073	alpha beta
HC662_RS12245	COG4918	Iron-sulphur cluster biosynthesis
HC662_RS12250	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC662_RS12250	COG0456	acetyltransferase
HC662_RS12255	COG2329	Antibiotic biosynthesis monooxygenase
HC662_RS12260	COG0456	acetyltransferase
HC662_RS12270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC662_RS12285	COG2211	Major facilitator Superfamily
HC662_RS12295	COG0346	lactoylglutathione lyase activity
HC662_RS12300	COG1072	(Pantothenic acid kinase))
HC662_RS12305	COG3048	D-serine ammonia-lyase activity
HC662_RS12310	COG0300	oxidoreductase activity
HC662_RS12315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_RS12325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC662_RS12335	COG0706	membrane insertase activity
HC662_RS12340	COG3361	conserved protein (COG2071)
HC662_RS12345	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC662_RS12350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC662_RS12355	COG0346	lactoylglutathione lyase activity
HC662_RS12365	COG1376	ErfK ybiS ycfS ynhG family protein
HC662_RS12370	COG4129	membrane
HC662_RS12375	COG1126	abc transporter atp-binding protein
HC662_RS12380	COG0765	amino acid transport
HC662_RS12385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_RS12395	COG1597	lipid kinase activity
HC662_RS12400	COG2814	Major facilitator Superfamily
HC662_RS12410	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC662_RS12415	COG0022	dehydrogenase e1 component
HC662_RS12420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC662_RS12425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC662_RS12430	COG3426	butyrate kinase activity
HC662_RS12435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC662_RS12440	COG0280	phosphate acetyltransferase
HC662_RS12445	COG3829	transcription factor binding
HC662_RS12445	COG3290	protein histidine kinase activity
HC662_RS12455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HC662_RS12460	COG2079	MmgE PrpD family protein
HC662_RS12465	COG0372	Belongs to the citrate synthase family
HC662_RS12470	COG1960	acyl-CoA dehydrogenase activity
HC662_RS12475	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC662_RS12480	COG0183	Belongs to the thiolase family
HC662_RS12485	COG0584	glycerophosphoryl diester phosphodiesterase
HC662_RS12490	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_RS12505	COG1902	pentaerythritol trinitrate reductase activity
HC662_RS12515	COG0745	RESPONSE REGULATOR receiver
HC662_RS12520	COG0750	zinc metalloprotease
HC662_RS12525	COG0497	DNA recombination
HC662_RS12530	COG1438	arginine binding
HC662_RS12535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HC662_RS12540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HC662_RS12545	COG0142	geranyltranstransferase activity
HC662_RS12550	COG1722	exodeoxyribonuclease VII activity
HC662_RS12560	COG3854	ATPases associated with a variety of cellular activities
HC662_RS12570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC662_RS12575	COG0006	proline dipeptidase activity
HC662_RS12580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HC662_RS12590	COG3872	metal-dependent enzyme
HC662_RS12600	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC662_RS12605	COG1321	iron dependent repressor
HC662_RS12610	COG0095	Lipoate-protein ligase
HC662_RS12615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_RS12620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC662_RS12625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC662_RS12630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC662_RS12635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC662_RS12650	COG1396	sequence-specific DNA binding
HC662_RS12660	COG0681	Belongs to the peptidase S26 family
HC662_RS12685	COG4940	Competence protein ComGF
HC662_RS12695	COG4970	Tfp pilus assembly protein FimT
HC662_RS12700	COG4537	Required for transformation and DNA binding
HC662_RS12705	COG1459	type II secretion system
HC662_RS12710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC662_RS12720	COG0517	IMP dehydrogenase activity
HC662_RS12725	COG0598	Magnesium transport protein CorA
HC662_RS12730	COG1253	flavin adenine dinucleotide binding
HC662_RS12735	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_RS12745	COG1393	Belongs to the ArsC family
HC662_RS12755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_RS12765	COG0011	TIGRFAM Protein of
HC662_RS12775	COG2866	Carboxypeptidase
HC662_RS12780	COG1368	sulfuric ester hydrolase activity
HC662_RS12785	COG1940	carbohydrate kinase activity
HC662_RS12790	COG4483	Protein conserved in bacteria
HC662_RS12795	COG0705	Rhomboid family
HC662_RS12795	COG0457	Tetratricopeptide repeat
HC662_RS12805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC662_RS12815	COG0438	transferase activity, transferring glycosyl groups
HC662_RS12830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC662_RS12835	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC662_RS12840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC662_RS12845	COG0581	inorganic phosphate transmembrane transporter activity
HC662_RS12850	COG0573	inorganic phosphate transmembrane transporter activity
HC662_RS12855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC662_RS12865	COG0477	Major facilitator Superfamily
HC662_RS12870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC662_RS12875	COG2839	Protein conserved in bacteria
HC662_RS12880	COG5521	maltodextrose utilization protein MalA
HC662_RS12885	COG1388	LysM domain
HC662_RS12890	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HC662_RS12895	COG4709	membrane
HC662_RS12900	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HC662_RS12905	COG0735	belongs to the Fur family
HC662_RS12910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_RS12920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HC662_RS12925	COG0513	Belongs to the DEAD box helicase family
HC662_RS12935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HC662_RS12940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC662_RS12950	COG2010	Cytochrome c
HC662_RS12955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC662_RS12960	COG0358	DNA primase activity
HC662_RS12965	COG1671	Belongs to the UPF0178 family
HC662_RS12970	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HC662_RS12975	COG0517	IMP dehydrogenase activity
HC662_RS12980	COG0751	glycine-tRNA ligase activity
HC662_RS12985	COG0752	glycyl-tRNA synthetase alpha subunit
HC662_RS12990	COG1381	Involved in DNA repair and RecF pathway recombination
HC662_RS13000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC662_RS13005	COG0295	cytidine deaminase activity
HC662_RS13010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC662_RS13015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC662_RS13020	COG1480	7TM receptor with intracellular HD hydrolase
HC662_RS13025	COG1702	phosphate starvation-inducible protein PhoH
HC662_RS13030	COG0561	phosphatase activity
HC662_RS13045	COG4864	UPF0365 protein
HC662_RS13050	COG1030	water channel activity
HC662_RS13055	COG1610	YqeY-like protein
HC662_RS13065	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC662_RS13070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC662_RS13075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC662_RS13080	COG2264	protein methyltransferase activity
HC662_RS13095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC662_RS13100	COG1420	regulation of RNA biosynthetic process
HC662_RS13105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC662_RS13110	COG0481	GTPase activity
HC662_RS13120	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_RS13125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HC662_RS13130	COG0268	Binds directly to 16S ribosomal RNA
HC662_RS13135	COG1466	dna polymerase III delta subunit
HC662_RS13150	COG0658	competence protein
HC662_RS13150	COG2333	competence protein COMEC
HC662_RS13155	COG2131	deaminase
HC662_RS13160	COG1555	photosystem II stabilization
HC662_RS13160	COG1596	polysaccharide export
HC662_RS13165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC662_RS13170	COG2226	methyltransferase
HC662_RS13175	COG0799	negative regulation of ribosome biogenesis
HC662_RS13180	COG1713	HD superfamily hydrolase involved in NAD metabolism
HC662_RS13185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC662_RS13190	COG1534	Rna-binding protein
HC662_RS13195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC662_RS13200	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC662_RS13205	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HC662_RS13215	COG2755	lipolytic protein G-D-S-L family
HC662_RS13220	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_RS13220	COG3409	Peptidoglycan-binding domain 1 protein
HC662_RS13225	COG0398	Pfam SNARE associated Golgi protein
HC662_RS13230	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HC662_RS13240	COG3209	COG3209 Rhs family protein
HC662_RS13255	COG2323	membrane
HC662_RS13260	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HC662_RS13265	COG0730	response to heat
HC662_RS13270	COG0425	Belongs to the sulfur carrier protein TusA family
HC662_RS13275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_RS13275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_RS13280	COG2210	Belongs to the sulfur carrier protein TusA family
HC662_RS13285	COG0425	Belongs to the sulfur carrier protein TusA family
HC662_RS13285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_RS13295	COG2210	Belongs to the sulfur carrier protein TusA family
HC662_RS13300	COG1937	Protein conserved in bacteria
HC662_RS13310	COG0662	Cupin 2, conserved barrel domain protein
HC662_RS13320	COG0604	alcohol dehydrogenase
HC662_RS13330	COG2315	Protein conserved in bacteria
HC662_RS13335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC662_RS13350	COG0583	DNA-binding transcription factor activity
HC662_RS13355	COG0457	Tetratricopeptide repeat
HC662_RS13370	COG5444	nuclease activity
HC662_RS13380	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_RS13380	COG3409	Peptidoglycan-binding domain 1 protein
HC662_RS13385	COG4824	toxin secretion phage lysis holin
HC662_RS13410	COG0563	adenylate kinase activity
HC662_RS13460	COG0697	spore germination
HC662_RS13465	COG2207	Transcriptional regulator
HC662_RS13465	COG1917	Cupin 2, conserved barrel domain protein
HC662_RS13470	COG2318	DinB family
HC662_RS13475	COG0456	acetyltransferase
HC662_RS13480	COG0477	Major facilitator Superfamily
HC662_RS13485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_RS13535	COG4978	Transcriptional regulator
HC662_RS13535	COG0789	Transcriptional regulator
HC662_RS13540	COG0747	negative chemotaxis
HC662_RS13545	COG0601	transmembrane transport
HC662_RS13550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC662_RS13555	COG0444	Belongs to the ABC transporter superfamily
HC662_RS13560	COG4608	Belongs to the ABC transporter superfamily
HC662_RS13565	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC662_RS13575	COG2851	Citrate transporter
HC662_RS13580	COG0583	DNA-binding transcription factor activity
HC662_RS13585	COG2828	Protein conserved in bacteria
HC662_RS13590	COG3409	Peptidoglycan-binding domain 1 protein
HC662_RS13595	COG5566	PFAM Mor transcription activator
HC662_RS13600	COG0596	Alpha beta hydrolase
HC662_RS13605	COG0697	spore germination
HC662_RS13610	COG0110	maltose O-acetyltransferase activity
HC662_RS13615	COG4991	sh3 domain protein
HC662_RS13620	COG4991	sh3 domain protein
HC662_RS13630	COG5577	PFAM Coat F domain
HC662_RS13635	COG1063	alcohol dehydrogenase
HC662_RS13645	COG5577	PFAM Coat F domain
HC662_RS13660	COG0693	protein deglycase activity
HC662_RS13665	COG1621	beta-fructofuranosidase activity
HC662_RS13675	COG3716	PTS system mannose fructose sorbose family IID component
HC662_RS13680	COG3715	PTS system
HC662_RS13685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS13690	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS13700	COG1113	amino acid transport
HC662_RS13705	COG1280	lysine exporter protein (LysE YggA)
HC662_RS13710	COG1378	Sugar-specific transcriptional regulator TrmB
HC662_RS13715	COG1595	DNA-templated transcription, initiation
HC662_RS13725	COG2755	lipolytic protein G-D-S-L family
HC662_RS13725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HC662_RS13735	COG2124	cytochrome p450
HC662_RS13735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC662_RS13740	COG1309	transcriptional regulator
HC662_RS13745	COG2226	methyltransferase
HC662_RS13760	COG2116	formate transmembrane transporter activity
HC662_RS13765	COG5609	conserved protein (DUF2294)
HC662_RS13770	COG3383	formate dehydrogenase (NAD+) activity
HC662_RS13775	COG2427	Protein of unknown function (DUF1641)
HC662_RS13785	COG0626	cystathionine gamma-synthase activity
HC662_RS13790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC662_RS13795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC662_RS13800	COG2226	methyltransferase
HC662_RS13815	COG0768	penicillin binding
HC662_RS13820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC662_RS13825	COG0572	uridine kinase
HC662_RS13840	COG4122	O-methyltransferase activity
HC662_RS13845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC662_RS13850	COG3906	Belongs to the UPF0473 family
HC662_RS13855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC662_RS13860	COG4472	Bacterial protein of unknown function (DUF965)
HC662_RS13865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC662_RS13870	COG0628	permease
HC662_RS13875	COG1126	abc transporter atp-binding protein
HC662_RS13880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_RS13885	COG0765	amino acid transport
HC662_RS13890	COG0765	amino acid transport
HC662_RS13905	COG3881	PFAM PRC-barrel domain
HC662_RS13910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC662_RS13915	COG0457	Tetratricopeptide repeat
HC662_RS13920	COG0482	sulfurtransferase activity
HC662_RS13925	COG1104	cysteine desulfurase activity
HC662_RS13930	COG1959	2 iron, 2 sulfur cluster binding
HC662_RS13935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC662_RS13950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC662_RS13955	COG0124	histidyl-tRNA synthetase
HC662_RS13965	COG3103	Sh3 type 3 domain protein
HC662_RS13965	COG4991	sh3 domain protein
HC662_RS13965	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_RS13970	COG1490	D-aminoacyl-tRNA deacylase activity
HC662_RS13975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC662_RS13980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC662_RS13985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC662_RS13985	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HC662_RS13990	COG5416	Lipopolysaccharide assembly protein A domain
HC662_RS13995	COG0490	domain, Protein
HC662_RS14000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC662_RS14000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC662_RS14010	COG2244	polysaccharide biosynthetic process
HC662_RS14015	COG2323	membrane
HC662_RS14025	COG1862	Preprotein translocase
HC662_RS14030	COG0343	queuine tRNA-ribosyltransferase activity
HC662_RS14035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HC662_RS14045	COG2255	four-way junction helicase activity
HC662_RS14050	COG0632	four-way junction helicase activity
HC662_RS14060	COG2814	Major facilitator Superfamily
HC662_RS14065	COG0673	inositol 2-dehydrogenase activity
HC662_RS14070	COG2112	serine threonine protein kinase
HC662_RS14085	COG1115	amino acid carrier protein
HC662_RS14090	COG0217	transcriptional regulatory protein
HC662_RS14100	COG1388	LysM domain
HC662_RS14105	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC662_RS14110	COG0157	Belongs to the NadC ModD family
HC662_RS14115	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC662_RS14120	COG1104	cysteine desulfurase activity
HC662_RS14125	COG1827	regulation of RNA biosynthetic process
HC662_RS14130	COG0077	Prephenate dehydratase
HC662_RS14135	COG4492	Belongs to the UPF0735 family
HC662_RS14140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC662_RS14145	COG3290	protein histidine kinase activity
HC662_RS14155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC662_RS14160	COG2868	ribosomal protein
HC662_RS14165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC662_RS14170	COG1994	Peptidase M50
HC662_RS14175	COG0739	heme binding
HC662_RS14180	COG2894	cell division
HC662_RS14185	COG0850	regulation of cytokinetic process
HC662_RS14190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC662_RS14200	COG1077	Cell shape determining protein MreB Mrl
HC662_RS14205	COG2003	Belongs to the UPF0758 family
HC662_RS14210	COG0424	maF-like protein
HC662_RS14220	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HC662_RS14225	COG0285	dihydrofolate synthase activity
HC662_RS14230	COG0525	valine-tRNA ligase activity
HC662_RS14240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC662_RS14245	COG1388	LysM domain
HC662_RS14250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC662_RS14255	COG0113	porphobilinogen synthase activity
HC662_RS14260	COG1587	Uroporphyrinogen-III synthase
HC662_RS14265	COG0181	hydroxymethylbilane synthase activity
HC662_RS14270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC662_RS14275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HC662_RS14285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HC662_RS14295	COG0470	DNA polymerase III
HC662_RS14295	COG1067	ATP-dependent peptidase activity
HC662_RS14300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC662_RS14305	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC662_RS14310	COG1477	protein flavinylation
HC662_RS14310	COG0457	Tetratricopeptide repeat
HC662_RS14315	COG0066	3-isopropylmalate dehydratase activity
HC662_RS14320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HC662_RS14325	COG0473	3-isopropylmalate dehydrogenase activity
HC662_RS14330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC662_RS14335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HC662_RS14340	COG0440	acetolactate synthase activity
HC662_RS14345	COG0028	Belongs to the TPP enzyme family
HC662_RS14355	COG0454	-acetyltransferase
HC662_RS14360	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HC662_RS14375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC662_RS14380	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC662_RS14385	COG5401	PFAM Sporulation and spore germination
HC662_RS14390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC662_RS14395	COG1846	Transcriptional regulator
HC662_RS14400	COG2197	response regulator
HC662_RS14405	COG0824	Thioesterase
HC662_RS14410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC662_RS14415	COG1053	succinate dehydrogenase
HC662_RS14420	COG2009	succinate dehydrogenase
HC662_RS14425	COG1719	4-vinyl reductase, 4VR
HC662_RS14430	COG0527	aspartate kinase activity
HC662_RS14435	COG0322	excinuclease ABC activity
HC662_RS14440	COG3118	belongs to the thioredoxin family
HC662_RS14445	COG3534	alpha-L-arabinofuranosidase
HC662_RS14450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HC662_RS14455	COG2086	electron transfer activity
HC662_RS14460	COG1024	Enoyl-CoA hydratase
HC662_RS14465	COG1309	transcriptional regulator
HC662_RS14470	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_RS14475	COG3766	membrane
HC662_RS14480	COG1193	negative regulation of DNA recombination
HC662_RS14485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC662_RS14485	COG1796	DNA polymerase
HC662_RS14490	COG1286	toxin biosynthetic process
HC662_RS14495	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HC662_RS14500	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC662_RS14505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_RS14505	COG0072	phenylalanine-tRNA ligase activity
HC662_RS14510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC662_RS14520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC662_RS14530	COG3835	regulator
HC662_RS14535	COG0277	FAD linked oxidase domain protein
HC662_RS14540	COG0247	lactate metabolic process
HC662_RS14545	COG0346	lactoylglutathione lyase activity
HC662_RS14550	COG1966	Carbon starvation protein
HC662_RS14565	COG1695	Transcriptional regulator
HC662_RS14570	COG3534	alpha-L-arabinofuranosidase
HC662_RS14575	COG0395	ABC-type sugar transport system, permease component
HC662_RS14580	COG1175	transmembrane transport
HC662_RS14585	COG1653	transport
HC662_RS14590	COG0371	Dehydrogenase
HC662_RS14595	COG0647	UMP catabolic process
HC662_RS14600	COG0235	Class ii aldolase
HC662_RS14605	COG1069	ribulokinase activity
HC662_RS14610	COG2160	L-arabinose isomerase activity
HC662_RS14615	COG3507	Belongs to the glycosyl hydrolase 43 family
HC662_RS14620	COG1363	Peptidase, m42
HC662_RS14630	COG3326	Membrane
HC662_RS14635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC662_RS14640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC662_RS14645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC662_RS14650	COG1346	cytolysis
HC662_RS14655	COG1380	Effector of murein hydrolase LrgA
HC662_RS14660	COG3279	Response regulator of the LytR AlgR family
HC662_RS14665	COG3275	phosphorelay sensor kinase activity
HC662_RS14670	COG1011	Hydrolase
HC662_RS14675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC662_RS14685	COG0398	Pfam SNARE associated Golgi protein
HC662_RS14690	COG1484	DNA-dependent DNA replication
HC662_RS14695	COG3611	Membrane attachment protein
HC662_RS14700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC662_RS14705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HC662_RS14710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC662_RS14715	COG1733	regulation of RNA biosynthetic process
HC662_RS14720	COG2814	Major facilitator Superfamily
HC662_RS14725	COG0656	L-ascorbic acid biosynthetic process
HC662_RS14730	COG0237	dephospho-CoA kinase activity
HC662_RS14735	COG1971	Probably functions as a manganese efflux pump
HC662_RS14740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC662_RS14745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC662_RS14745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC662_RS14750	COG5002	protein histidine kinase activity
HC662_RS14755	COG0745	RESPONSE REGULATOR receiver
HC662_RS14760	COG0039	L-malate dehydrogenase activity
HC662_RS14765	COG0538	isocitrate dehydrogenase activity
HC662_RS14770	COG0372	Belongs to the citrate synthase family
HC662_RS14775	COG2707	UPF0756 membrane protein
HC662_RS14780	COG0628	permease
HC662_RS14785	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC662_RS14790	COG0469	pyruvate kinase activity
HC662_RS14795	COG0205	6-phosphofructokinase activity
HC662_RS14800	COG0825	malonyl-CoA metabolic process
HC662_RS14805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC662_RS14810	COG0281	malic enzyme
HC662_RS14815	COG0587	DNA-directed DNA polymerase activity
HC662_RS14835	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HC662_RS14845	COG4109	DRTGG domain
HC662_RS14850	COG0730	response to heat
HC662_RS14855	COG1473	amidohydrolase
HC662_RS14865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_RS14870	COG0454	-acetyltransferase
HC662_RS14875	COG0583	DNA-binding transcription factor activity
HC662_RS14885	COG1714	RDD family
HC662_RS14890	COG0616	signal peptide processing
HC662_RS14895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC662_RS14900	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HC662_RS14905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC662_RS14915	COG0301	tRNA thio-modification
HC662_RS14920	COG1104	cysteine desulfurase activity
HC662_RS14925	COG1114	Component of the transport system for branched-chain amino acids
HC662_RS14930	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HC662_RS14935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC662_RS14940	COG1309	transcriptional regulator
HC662_RS14945	COG1956	GAF domain-containing protein
HC662_RS14950	COG2203	Gaf domain
HC662_RS14950	COG2199	diguanylate cyclase activity
HC662_RS14960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC662_RS14965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC662_RS14970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC662_RS14975	COG0454	-acetyltransferase
HC662_RS14980	COG0517	IMP dehydrogenase activity
HC662_RS14985	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC662_RS14990	COG1360	Flagellar Motor Protein
HC662_RS14995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC662_RS15000	COG1609	Transcriptional regulator
HC662_RS15005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HC662_RS15005	COG1605	Chorismate mutase
HC662_RS15010	COG3118	belongs to the thioredoxin family
HC662_RS15015	COG4980	gas vesicle protein
HC662_RS15020	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC662_RS15025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC662_RS15030	COG1674	ftsk spoiiie
HC662_RS15035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_RS15040	COG4848	Belongs to the UPF0354 family
HC662_RS15045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_RS15060	COG1363	Peptidase, m42
HC662_RS15065	COG5584	Small secreted protein
HC662_RS15070	COG0281	malic enzyme
HC662_RS15075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_RS15080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC662_RS15090	COG0510	thiamine kinase activity
HC662_RS15095	COG1523	belongs to the glycosyl hydrolase 13 family
HC662_RS15100	COG1597	lipid kinase activity
HC662_RS15110	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC662_RS15115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC662_RS15120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC662_RS15125	COG2252	PERMEase
HC662_RS15130	COG4473	ABC transporter
HC662_RS15135	COG1131	(ABC) transporter
HC662_RS15140	COG1349	DNA-binding transcription factor activity
HC662_RS15145	COG1187	pseudouridine synthase activity
HC662_RS15150	COG2244	polysaccharide biosynthetic process
HC662_RS15155	COG2081	HI0933 family
HC662_RS15160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC662_RS15170	COG5578	integral membrane protein
HC662_RS15175	COG0673	inositol 2-dehydrogenase activity
HC662_RS15180	COG1653	transport
HC662_RS15185	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC662_RS15190	COG4209	transmembrane transport
HC662_RS15195	COG2207	Transcriptional regulator
HC662_RS15200	COG1653	transport
HC662_RS15205	COG0395	ABC-type sugar transport system, permease component
HC662_RS15210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_RS15215	COG2124	cytochrome p450
HC662_RS15220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HC662_RS15230	COG0156	8-amino-7-oxononanoate synthase activity
HC662_RS15235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC662_RS15240	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HC662_RS15250	COG1073	alpha beta
HC662_RS15255	COG1609	Transcriptional regulator
HC662_RS15260	COG1653	transport
HC662_RS15265	COG1175	transmembrane transport
HC662_RS15270	COG0395	ABC-type sugar transport system, permease component
HC662_RS15275	COG1486	melibiose metabolic process
HC662_RS15280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_RS15285	COG0495	leucyl-tRNA aminoacylation
HC662_RS15295	COG2202	Pas domain
HC662_RS15295	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_RS15300	COG2814	Major facilitator Superfamily
HC662_RS15305	COG2433	Pfam Transposase IS66
HC662_RS15310	COG0577	efflux transmembrane transporter activity
HC662_RS15315	COG1136	(ABC) transporter
HC662_RS15320	COG2205	protein histidine kinase activity
HC662_RS15325	COG0745	RESPONSE REGULATOR receiver
HC662_RS15330	COG0577	efflux transmembrane transporter activity
HC662_RS15335	COG1136	(ABC) transporter
HC662_RS15350	COG1131	(ABC) transporter
HC662_RS15355	COG1725	Transcriptional regulator
HC662_RS15370	COG1242	4 iron, 4 sulfur cluster binding
HC662_RS15375	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC662_RS15385	COG2267	carboxylic ester hydrolase activity
HC662_RS15390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC662_RS15395	COG1113	amino acid transport
HC662_RS15400	COG0367	asparagine synthase
HC662_RS15405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC662_RS15410	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HC662_RS15420	COG1506	peptidase
HC662_RS15425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC662_RS15430	COG1116	anion transmembrane transporter activity
HC662_RS15435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC662_RS15440	COG0494	nUDIX hydrolase
HC662_RS15445	COG4824	toxin secretion phage lysis holin
HC662_RS15450	COG0783	Belongs to the Dps family
HC662_RS15465	COG1854	S-ribosylhomocysteine lyase activity
HC662_RS15470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC662_RS15475	COG0288	reversible hydration of carbon dioxide
HC662_RS15480	COG0254	rRNA binding
HC662_RS15485	COG1271	oxidase subunit
HC662_RS15490	COG1294	oxidase, subunit
HC662_RS15500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC662_RS15505	COG1321	iron dependent repressor
HC662_RS15505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC662_RS15510	COG1121	(ABC) transporter
HC662_RS15515	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC662_RS15520	COG4948	Mandelate Racemase Muconate Lactonizing
HC662_RS15525	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_RS15530	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HC662_RS15535	COG0596	Alpha beta hydrolase
HC662_RS15540	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HC662_RS15545	COG1169	isochorismate synthase
HC662_RS15550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC662_RS15555	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HC662_RS15560	COG0058	SHG alpha-glucan phosphorylase activity
HC662_RS15565	COG0297	glycogen (starch) synthase activity
HC662_RS15570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC662_RS15575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC662_RS15580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HC662_RS15705	COG3859	Proton-coupled thiamine transporter YuaJ
HC662_RS15710	COG1247	-acetyltransferase
HC662_RS15715	COG2268	Band 7 protein
HC662_RS15720	COG1585	Membrane protein implicated in regulation of membrane protease activity
HC662_RS15725	COG2318	DinB family
HC662_RS15735	COG1454	alcohol dehydrogenase
HC662_RS15740	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS15745	COG1510	regulation of RNA biosynthetic process
HC662_RS15755	COG0569	domain protein
HC662_RS15760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC662_RS15765	COG4682	membrane
HC662_RS15770	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC662_RS15775	COG0477	Major facilitator Superfamily
HC662_RS15780	COG5553	Cysteine dioxygenase type I
HC662_RS15790	COG1968	undecaprenyl-diphosphatase activity
HC662_RS15795	COG0628	permease
HC662_RS15800	COG0673	inositol 2-dehydrogenase activity
HC662_RS15805	COG4806	L-rhamnose isomerase
HC662_RS15810	COG3254	rhamnose metabolic process
HC662_RS15815	COG1070	Carbohydrate kinase
HC662_RS15820	COG1349	DNA-binding transcription factor activity
HC662_RS15825	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS15825	COG3347	Dehydrogenase
HC662_RS15830	COG0840	transmembrane signaling receptor activity
HC662_RS15835	COG0840	transmembrane signaling receptor activity
HC662_RS15840	COG0840	transmembrane signaling receptor activity
HC662_RS15845	COG0840	transmembrane signaling receptor activity
HC662_RS15860	COG2070	2-Nitropropane dioxygenase
HC662_RS15865	COG0432	Pfam Uncharacterised protein family UPF0047
HC662_RS15870	COG0366	Alpha amylase catalytic
HC662_RS15875	COG1253	flavin adenine dinucleotide binding
HC662_RS15880	COG2738	Putative neutral zinc metallopeptidase
HC662_RS15895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC662_RS15910	COG0166	Belongs to the GPI family
HC662_RS15915	COG1979	alcohol dehydrogenase
HC662_RS15920	COG1979	alcohol dehydrogenase
HC662_RS15925	COG2155	Conserved Protein
HC662_RS15930	COG1098	S1 RNA binding domain
HC662_RS15935	COG0436	Aminotransferase
HC662_RS15940	COG1522	sequence-specific DNA binding
HC662_RS15945	COG2267	carboxylic ester hydrolase activity
HC662_RS15955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC662_RS15960	COG2205	protein histidine kinase activity
HC662_RS15970	COG5018	Exonuclease
HC662_RS15980	COG2814	Major facilitator Superfamily
HC662_RS15985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC662_RS15990	COG3011	Protein conserved in bacteria
HC662_RS16000	COG3290	protein histidine kinase activity
HC662_RS16005	COG4565	transcriptional regulatory protein
HC662_RS16030	COG3493	citrate carrier protein
HC662_RS16040	COG2111	Na H antiporter
HC662_RS16040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC662_RS16045	COG2111	Na H antiporter
HC662_RS16050	COG1006	Multisubunit Na H antiporter MnhC subunit
HC662_RS16055	COG0651	ATP synthesis coupled electron transport
HC662_RS16060	COG1863	multisubunit Na H antiporter MnhE subunit
HC662_RS16065	COG2212	antiporter activity
HC662_RS16070	COG1320	monovalent cation:proton antiporter activity
HC662_RS16075	COG2050	protein possibly involved in aromatic compounds catabolism
HC662_RS16080	COG2197	response regulator
HC662_RS16085	COG4585	Histidine kinase
HC662_RS16095	COG0142	geranyltranstransferase activity
HC662_RS16115	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HC662_RS16120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HC662_RS16125	COG1335	isochorismatase
HC662_RS16130	COG5506	Protein of unknown function (DUF1694)
HC662_RS16145	COG0628	permease
HC662_RS16160	COG1418	mRNA catabolic process
HC662_RS16165	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS16175	COG1511	domain protein
HC662_RS16180	COG1674	ftsk spoiiie
HC662_RS16180	COG0433	COG0433 Predicted ATPase
HC662_RS16185	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC662_RS16190	COG5417	Belongs to the EsaB family
HC662_RS16195	COG4842	Belongs to the WXG100 family
HC662_RS16200	COG2508	Transcriptional regulator
HC662_RS16200	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC662_RS16205	COG0686	Belongs to the AlaDH PNT family
HC662_RS16210	COG5634	Uncharacterized conserved protein (DUF2278)
HC662_RS16215	COG3251	PFAM MbtH domain protein
HC662_RS16220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS16225	COG1535	isochorismatase
HC662_RS16225	COG3433	isochorismatase activity
HC662_RS16230	COG1021	2,3-dihydroxybenzoate-AMP ligase
HC662_RS16235	COG1169	isochorismate synthase
HC662_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS16245	COG2819	hydrolase of the alpha beta superfamily
HC662_RS16250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC662_RS16255	COG1268	BioY protein
HC662_RS16260	COG2056	Na+-H+ antiporter family
HC662_RS16265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HC662_RS16270	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HC662_RS16275	COG3584	3D domain protein
HC662_RS16290	COG1252	NADH dehydrogenase
HC662_RS16295	COG0492	ferredoxin-NADP+ reductase activity
HC662_RS16305	COG0516	GMP reductase activity
HC662_RS16310	COG2808	Putative FMN-binding domain
HC662_RS16315	COG0456	acetyltransferase
HC662_RS16320	COG0316	Belongs to the HesB IscA family
HC662_RS16325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HC662_RS16330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC662_RS16335	COG4844	belongs to the
HC662_RS16340	COG1252	NADH dehydrogenase
HC662_RS16345	COG4837	Protein of unknown function (DUF1462)
HC662_RS16350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HC662_RS16355	COG4946	Tricorn protease homolog
HC662_RS16355	COG0823	Involved in the tonB-independent uptake of proteins
HC662_RS16355	COG1506	peptidase
HC662_RS16360	COG0083	homoserine kinase activity
HC662_RS16365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC662_RS16370	COG0460	homoserine dehydrogenase
HC662_RS16375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC662_RS16380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC662_RS16385	COG0647	UMP catabolic process
HC662_RS16390	COG2445	Protein of unknown function DUF86
HC662_RS16395	COG4470	Protein conserved in bacteria
HC662_RS16405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HC662_RS16410	COG0739	heme binding
HC662_RS16420	COG3377	Domain of unknown function (DUF1805)
HC662_RS16425	COG0737	Belongs to the 5'-nucleotidase family
HC662_RS16430	COG0730	response to heat
HC662_RS16435	COG1801	Protein of unknown function DUF72
HC662_RS16445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC662_RS16450	COG2508	Transcriptional regulator
HC662_RS16455	COG2233	PERMEase
HC662_RS16460	COG2233	PERMEase
HC662_RS16465	COG3195	allantoin biosynthetic process
HC662_RS16465	COG3648	Uricase
HC662_RS16470	COG2351	hydroxyisourate hydrolase activity
HC662_RS16515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC662_RS16525	COG0457	Tetratricopeptide repeat
HC662_RS16560	COG2080	2 iron, 2 sulfur cluster binding
HC662_RS16565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC662_RS16570	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HC662_RS16575	COG2068	MobA-Related Protein
HC662_RS16580	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HC662_RS16585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC662_RS16590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC662_RS16600	COG2356	endonuclease I
HC662_RS16605	COG3842	ATPase activity
HC662_RS16610	COG2188	Transcriptional regulator
HC662_RS16615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_RS16620	COG0395	ABC-type sugar transport system, permease component
HC662_RS16625	COG1175	transmembrane transport
HC662_RS16630	COG1653	transport
HC662_RS16635	COG2222	sugar isomerase
HC662_RS16640	COG0322	excinuclease ABC activity
HC662_RS16645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC662_RS16660	COG0346	lactoylglutathione lyase activity
HC662_RS16665	COG0640	Transcriptional regulator
HC662_RS16670	COG0719	Fe-S assembly protein
HC662_RS16675	COG0822	iron-sulfur transferase activity
HC662_RS16680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC662_RS16685	COG0719	Fe-S assembly protein
HC662_RS16690	COG0396	ATPase activity
HC662_RS16700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC662_RS16705	COG1464	Belongs to the NlpA lipoprotein family
HC662_RS16710	COG2011	ABC-type metal ion transport system permease component
HC662_RS16715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC662_RS16725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_RS16730	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC662_RS16740	COG0509	glycine decarboxylation via glycine cleavage system
HC662_RS16745	COG1393	Belongs to the ArsC family
HC662_RS16750	COG1960	acyl-CoA dehydrogenase activity
HC662_RS16755	COG0183	Belongs to the thiolase family
HC662_RS16760	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC662_RS16760	COG1024	Enoyl-CoA hydratase
HC662_RS16770	COG0506	proline dehydrogenase activity
HC662_RS16780	COG5577	PFAM Coat F domain
HC662_RS16790	COG0477	Major facilitator Superfamily
HC662_RS16795	COG1942	4-Oxalocrotonate Tautomerase
HC662_RS16800	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS16805	COG0583	DNA-binding transcription factor activity
HC662_RS16815	COG1120	ATPase activity
HC662_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS16835	COG0783	Belongs to the Dps family
HC662_RS16840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC662_RS16845	COG0745	RESPONSE REGULATOR receiver
HC662_RS16850	COG2205	protein histidine kinase activity
HC662_RS16850	COG2770	Histidine kinase
HC662_RS16860	COG1309	transcriptional regulator
HC662_RS16865	COG0114	fumarate hydratase activity
HC662_RS16875	COG0697	spore germination
HC662_RS16880	COG0814	amino acid
HC662_RS16890	COG2197	response regulator
HC662_RS16895	COG4585	Histidine kinase
HC662_RS16900	COG4758	membrane
HC662_RS16905	COG3595	metallopeptidase activity
HC662_RS16910	COG1842	Phage shock protein A
HC662_RS16915	COG4758	membrane
HC662_RS16920	COG2814	Major facilitator Superfamily
HC662_RS16925	COG2096	Adenosyltransferase
HC662_RS16930	COG1120	ATPase activity
HC662_RS16935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS16940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_RS16945	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS16950	COG3386	PFAM SMP-30 Gluconolaconase
HC662_RS16955	COG2205	protein histidine kinase activity
HC662_RS16960	COG0745	RESPONSE REGULATOR receiver
HC662_RS16970	COG1191	sigma factor activity
HC662_RS16980	COG2140	Oxalate decarboxylase
HC662_RS16990	COG0577	efflux transmembrane transporter activity
HC662_RS16995	COG1136	(ABC) transporter
HC662_RS17000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC662_RS17005	COG1120	ATPase activity
HC662_RS17010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS17015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_RS17020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_RS17025	COG0531	amino acid
HC662_RS17035	COG1988	membrane-bound metal-dependent
HC662_RS17045	COG1910	domain protein
HC662_RS17050	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC662_RS17055	COG4149	molybdate abc transporter
HC662_RS17060	COG0656	L-ascorbic acid biosynthetic process
HC662_RS17070	COG0025	NhaP-type Na H and K H
HC662_RS17080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC662_RS17085	COG3973	AAA domain
HC662_RS17090	COG2860	membrane
HC662_RS17095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HC662_RS17100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC662_RS17105	COG2217	Heavy metal translocating P-type atpase
HC662_RS17110	COG2217	Heavy metal translocating P-type atpase
HC662_RS17115	COG2608	mercury ion transmembrane transporter activity
HC662_RS17120	COG1937	Protein conserved in bacteria
HC662_RS17125	COG0673	inositol 2-dehydrogenase activity
HC662_RS17130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC662_RS17135	COG1289	transmembrane transporter activity
HC662_RS17150	COG2076	Multidrug Resistance protein
HC662_RS17155	COG1309	transcriptional regulator
HC662_RS17160	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS17170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HC662_RS17175	COG0557	exoribonuclease II activity
HC662_RS17180	COG1647	Serine aminopeptidase, S33
HC662_RS17185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC662_RS17190	COG0596	Alpha beta hydrolase
HC662_RS17195	COG1476	TRANSCRIPTIONal
HC662_RS17200	COG1396	sequence-specific DNA binding
HC662_RS17205	COG1396	sequence-specific DNA binding
HC662_RS17210	COG1733	regulation of RNA biosynthetic process
HC662_RS17235	COG1174	glycine betaine transport
HC662_RS17240	COG1732	Glycine betaine
HC662_RS17245	COG1174	glycine betaine transport
HC662_RS17250	COG0517	IMP dehydrogenase activity
HC662_RS17250	COG1125	glycine betaine transport
HC662_RS17255	COG1510	regulation of RNA biosynthetic process
HC662_RS17260	COG1174	glycine betaine transport
HC662_RS17265	COG1732	Glycine betaine
HC662_RS17270	COG1174	glycine betaine transport
HC662_RS17275	COG0517	IMP dehydrogenase activity
HC662_RS17275	COG1125	glycine betaine transport
HC662_RS17280	COG1510	regulation of RNA biosynthetic process
HC662_RS17290	COG3064	Membrane
HC662_RS17295	COG4640	response to antibiotic
HC662_RS17300	COG0456	acetyltransferase
HC662_RS17310	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HC662_RS17320	COG0126	phosphoglycerate kinase activity
HC662_RS17325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC662_RS17330	COG2390	Transcriptional regulator
HC662_RS17335	COG2814	Major facilitator Superfamily
HC662_RS17340	COG1609	Transcriptional regulator
HC662_RS17345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_RS17350	COG0583	DNA-binding transcription factor activity
HC662_RS17355	COG0697	spore germination
HC662_RS17360	COG1113	amino acid transport
HC662_RS17365	COG3858	chitin binding
HC662_RS17370	COG1556	Lactate utilization protein
HC662_RS17375	COG1139	Iron-sulfur cluster binding protein
HC662_RS17380	COG0247	lactate metabolic process
HC662_RS17385	COG2197	response regulator
HC662_RS17390	COG4585	Histidine kinase
HC662_RS17395	COG0842	Transport permease protein
HC662_RS17400	COG1131	(ABC) transporter
HC662_RS17405	COG0596	Alpha beta hydrolase
HC662_RS17410	COG2208	phosphoserine phosphatase activity
HC662_RS17415	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HC662_RS17420	COG1874	Beta-galactosidase
HC662_RS17425	COG3833	ABC-type maltose transport systems, permease component
HC662_RS17430	COG1175	transmembrane transport
HC662_RS17435	COG2182	Extracellular solute-binding protein
HC662_RS17440	COG1609	Transcriptional regulator
HC662_RS17445	COG2186	Transcriptional regulator
HC662_RS17450	COG1620	l-lactate permease
HC662_RS17455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC662_RS17465	COG5039	Polysaccharide pyruvyl transferase
HC662_RS17470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC662_RS17475	COG0110	maltose O-acetyltransferase activity
HC662_RS17480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC662_RS17485	COG2244	polysaccharide biosynthetic process
HC662_RS17490	COG1216	Glycosyl transferase, family 2
HC662_RS17495	COG5039	Polysaccharide pyruvyl transferase
HC662_RS17500	COG1216	Glycosyl transferase, family 2
HC662_RS17510	COG0438	transferase activity, transferring glycosyl groups
HC662_RS17515	COG1215	transferase activity, transferring glycosyl groups
HC662_RS17520	COG0438	transferase activity, transferring glycosyl groups
HC662_RS17525	COG1086	Polysaccharide biosynthesis protein
HC662_RS17530	COG0489	protein tyrosine kinase activity
HC662_RS17535	COG3944	biosynthesis protein
HC662_RS17540	COG1396	sequence-specific DNA binding
HC662_RS17545	COG2272	Belongs to the type-B carboxylesterase lipase family
HC662_RS17555	COG3479	Phenolic acid decarboxylase
HC662_RS17565	COG1794	racemase activity, acting on amino acids and derivatives
HC662_RS17570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC662_RS17580	COG1621	beta-fructofuranosidase activity
HC662_RS17585	COG1621	beta-fructofuranosidase activity
HC662_RS17590	COG0531	amino acid
HC662_RS17595	COG1309	transcriptional regulator
HC662_RS17600	COG2076	Multidrug Resistance protein
HC662_RS17605	COG2076	Multidrug Resistance protein
HC662_RS17625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC662_RS17630	COG0366	Alpha amylase catalytic
HC662_RS17635	COG1554	hydrolase, family 65, central catalytic
HC662_RS17640	COG5521	maltodextrose utilization protein MalA
HC662_RS17645	COG3833	ABC-type maltose transport systems, permease component
HC662_RS17650	COG1175	transmembrane transport
HC662_RS17665	COG3479	Phenolic acid decarboxylase
HC662_RS17675	COG1794	racemase activity, acting on amino acids and derivatives
HC662_RS17690	COG1621	beta-fructofuranosidase activity
HC662_RS17695	COG1621	beta-fructofuranosidase activity
HC662_RS17700	COG0531	amino acid
HC662_RS17705	COG1309	transcriptional regulator
HC662_RS17710	COG2076	Multidrug Resistance protein
HC662_RS17715	COG2076	Multidrug Resistance protein
HC662_RS17735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC662_RS17740	COG0366	Alpha amylase catalytic
HC662_RS17745	COG1554	hydrolase, family 65, central catalytic
HC662_RS17750	COG5521	maltodextrose utilization protein MalA
HC662_RS17765	COG2182	Extracellular solute-binding protein
HC662_RS17770	COG0366	Alpha amylase catalytic
HC662_RS17775	COG1609	Transcriptional regulator
HC662_RS17780	COG1611	Belongs to the LOG family
HC662_RS17785	COG1694	Mazg nucleotide pyrophosphohydrolase
HC662_RS17790	COG0659	secondary active sulfate transmembrane transporter activity
HC662_RS17795	COG0288	reversible hydration of carbon dioxide
HC662_RS17800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC662_RS17805	COG0577	efflux transmembrane transporter activity
HC662_RS17810	COG1136	(ABC) transporter
HC662_RS17815	COG5002	protein histidine kinase activity
HC662_RS17820	COG0745	RESPONSE REGULATOR receiver
HC662_RS17830	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HC662_RS17835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS17840	COG1481	regulation of sporulation
HC662_RS17845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC662_RS17850	COG1660	Displays ATPase and GTPase activities
HC662_RS17855	COG1051	belongs to the nudix hydrolase family
HC662_RS17860	COG0492	ferredoxin-NADP+ reductase activity
HC662_RS17865	COG0791	NLP P60 protein
HC662_RS17865	COG3883	PFAM NLP P60 protein
HC662_RS17870	COG0457	Tetratricopeptide repeat
HC662_RS17875	COG1132	(ABC) transporter
HC662_RS17880	COG0140	phosphoribosyl-ATP diphosphatase activity
HC662_RS17880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HC662_RS17885	COG0107	imidazoleglycerol-phosphate synthase activity
HC662_RS17890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HC662_RS17895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC662_RS17900	COG0131	Imidazoleglycerol-phosphate dehydratase
HC662_RS17905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HC662_RS17910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HC662_RS17915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HC662_RS17920	COG4990	cell redox homeostasis
HC662_RS17925	COG5297	Belongs to the glycosyl hydrolase family 6
HC662_RS17930	COG0110	maltose O-acetyltransferase activity
HC662_RS17935	COG0546	phosphoglycolate phosphatase activity
HC662_RS17940	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HC662_RS17945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC662_RS17950	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HC662_RS17955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC662_RS17960	COG0363	glucosamine-6-phosphate deaminase activity
HC662_RS17965	COG2188	Transcriptional regulator
HC662_RS17970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC662_RS17980	COG2814	Major facilitator Superfamily
HC662_RS17985	COG1950	PFAM Membrane protein of
HC662_RS17990	COG1983	PspC domain protein
HC662_RS17995	COG3595	metallopeptidase activity
HC662_RS18010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC662_RS18015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC662_RS18020	COG0556	nucleotide-excision repair
HC662_RS18025	COG4897	Protein conserved in bacteria
HC662_RS18035	COG0574	Belongs to the PEP-utilizing enzyme family
HC662_RS18035	COG3848	Pyruvate phosphate dikinase
HC662_RS18040	COG1309	transcriptional regulator
HC662_RS18045	COG2814	Major facilitator Superfamily
HC662_RS18050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC662_RS18060	COG0793	Belongs to the peptidase S41A family
HC662_RS18060	COG3409	Peptidoglycan-binding domain 1 protein
HC662_RS18065	COG2177	Part of the ABC transporter FtsEX involved in
HC662_RS18070	COG2884	Cell division ATP-binding protein ftsE
HC662_RS18075	COG2010	Cytochrome c
HC662_RS18080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_RS18095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC662_RS18110	COG1516	flagellar protein fliS
HC662_RS18115	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HC662_RS18120	COG1334	flagellar protein FlaG
HC662_RS18125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC662_RS18130	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC662_RS18135	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HC662_RS18145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC662_RS18150	COG1256	bacterial-type flagellum assembly
HC662_RS18150	COG4786	Flagellar basal body rod
HC662_RS18155	COG3418	PFAM FlgN family protein
HC662_RS18160	COG2747	anti-sigma28 factor FlgM
HC662_RS18170	COG1040	competence protein
HC662_RS18180	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HC662_RS18185	COG1307	EDD domain protein, DegV family
HC662_RS18190	COG2197	response regulator
HC662_RS18195	COG4585	Histidine kinase
HC662_RS18200	COG1739	Uncharacterized protein family UPF0029
HC662_RS18205	COG1316	TRANSCRIPTIONal
HC662_RS18210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC662_RS18215	COG0438	transferase activity, transferring glycosyl groups
HC662_RS18220	COG1215	transferase activity, transferring glycosyl groups
HC662_RS18225	COG3206	protein involved in exopolysaccharide biosynthesis
HC662_RS18230	COG3307	-O-antigen
HC662_RS18235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC662_RS18240	COG0297	glycogen (starch) synthase activity
HC662_RS18240	COG0438	transferase activity, transferring glycosyl groups
HC662_RS18245	COG2244	polysaccharide biosynthetic process
HC662_RS18260	COG2247	cell wall binding repeat
HC662_RS18260	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_RS18265	COG2385	sporulation resulting in formation of a cellular spore
HC662_RS18265	COG2247	cell wall binding repeat
HC662_RS18275	COG1316	TRANSCRIPTIONal
HC662_RS18280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HC662_RS18300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC662_RS18305	COG1134	teichoic acid transport
HC662_RS18310	COG1682	transport, permease protein
HC662_RS18315	COG1216	Glycosyl transferase, family 2
HC662_RS18315	COG1442	glycosyl transferase family 8
HC662_RS18325	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC662_RS18330	COG0463	Glycosyl transferase, family 2
HC662_RS18330	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC662_RS18345	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC662_RS18355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HC662_RS18390	COG4193	domain, Protein
HC662_RS18395	COG1482	cell wall glycoprotein biosynthetic process
HC662_RS18405	COG0814	amino acid
HC662_RS18415	COG2814	Major facilitator Superfamily
HC662_RS18420	COG1316	TRANSCRIPTIONal
HC662_RS18425	COG0561	phosphatase activity
HC662_RS18430	COG0791	NLP P60 protein
HC662_RS18440	COG2843	Capsule synthesis protein
HC662_RS18450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC662_RS18455	COG1609	Transcriptional regulator
HC662_RS18460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_RS18465	COG1869	D-ribose catabolic process
HC662_RS18470	COG1129	ABC transporter
HC662_RS18475	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC662_RS18480	COG1879	ABC-type sugar transport system periplasmic component
HC662_RS18485	COG3103	Sh3 type 3 domain protein
HC662_RS18495	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC662_RS18500	COG3527	Alpha-acetolactate decarboxylase
HC662_RS18505	COG0028	Belongs to the TPP enzyme family
HC662_RS18510	COG0583	DNA-binding transcription factor activity
HC662_RS18515	COG5337	Spore coat protein CotH
HC662_RS18525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC662_RS18535	COG0405	Gamma-glutamyltransferase
HC662_RS18540	COG1522	sequence-specific DNA binding
HC662_RS18545	COG2059	Chromate
HC662_RS18550	COG2059	Chromate
HC662_RS18570	COG5444	nuclease activity
HC662_RS18585	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC662_RS18590	COG4464	protein tyrosine phosphatase activity
HC662_RS18595	COG0489	protein tyrosine kinase activity
HC662_RS18600	COG3944	biosynthesis protein
HC662_RS18610	COG4715	Zinc finger, swim domain protein
HC662_RS18615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC662_RS18620	COG0561	phosphatase activity
HC662_RS18625	COG1349	DNA-binding transcription factor activity
HC662_RS18630	COG0629	single-stranded DNA binding
HC662_RS18645	COG2602	Beta-lactamase
HC662_RS18650	COG3764	Sortase (surface protein transpeptidase)
HC662_RS18660	COG3279	Response regulator of the LytR AlgR family
HC662_RS18665	COG2972	Histidine kinase
HC662_RS18665	COG0745	RESPONSE REGULATOR receiver
HC662_RS18670	COG1970	mechanosensitive ion channel activity
HC662_RS18675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC662_RS18680	COG0457	Tetratricopeptide repeat
HC662_RS18685	COG4786	Flagellar basal body rod
HC662_RS18690	COG4786	Flagellar basal body rod
HC662_RS18695	COG1077	Cell shape determining protein MreB Mrl
HC662_RS18700	COG1609	Transcriptional regulator
HC662_RS18710	COG1846	Transcriptional regulator
HC662_RS18715	COG2814	Major facilitator Superfamily
HC662_RS18720	COG3420	alginic acid biosynthetic process
HC662_RS18725	COG1953	Uracil, thiamine, allantoin
HC662_RS18730	COG0477	Major facilitator Superfamily
HC662_RS18735	COG1335	isochorismatase
HC662_RS18745	COG0004	ammonium transporteR
HC662_RS18750	COG0347	Belongs to the P(II) protein family
HC662_RS18755	COG0671	phosphoesterase, PA-phosphatase related
HC662_RS18765	COG0739	heme binding
HC662_RS18770	COG1247	-acetyltransferase
HC662_RS18780	COG1086	Polysaccharide biosynthesis protein
HC662_RS18785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_RS18790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC662_RS18795	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HC662_RS18810	COG2089	acid synthase
HC662_RS18820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC662_RS18825	COG0789	Transcriptional regulator
HC662_RS18835	COG2910	NAD(P)H-binding
HC662_RS18840	COG1959	2 iron, 2 sulfur cluster binding
HC662_RS18845	COG0804	urea catabolic process
HC662_RS18850	COG0832	Belongs to the urease beta subunit family
HC662_RS18855	COG0831	urea catabolic process
HC662_RS18885	COG3237	CsbD-like
HC662_RS18890	COG1994	Peptidase M50
HC662_RS18895	COG0457	Tetratricopeptide repeat
HC662_RS18900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC662_RS18905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HC662_RS18915	COG2304	oxidoreductase activity
HC662_RS18920	COG2304	oxidoreductase activity
HC662_RS18925	COG2385	sporulation resulting in formation of a cellular spore
HC662_RS18930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC662_RS18940	COG4836	Membrane
HC662_RS18955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC662_RS18960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HC662_RS18965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HC662_RS18970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC662_RS18975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC662_RS18985	COG0356	it plays a direct role in the translocation of protons across the membrane
HC662_RS18995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HC662_RS19000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC662_RS19005	COG4475	Protein of unknown function (DUF436)
HC662_RS19010	COG0698	ribose 5-phosphate isomerase
HC662_RS19020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC662_RS19025	COG1971	Probably functions as a manganese efflux pump
HC662_RS19030	COG0009	L-threonylcarbamoyladenylate synthase
HC662_RS19035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC662_RS19055	COG2890	protein-(glutamine-N5) methyltransferase activity
HC662_RS19060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC662_RS19065	COG0346	lactoylglutathione lyase activity
HC662_RS19070	COG0789	Transcriptional regulator
HC662_RS19075	COG0679	Auxin Efflux Carrier
HC662_RS19080	COG0281	malic enzyme
HC662_RS19085	COG1435	thymidine kinase activity
HC662_RS19095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC662_RS19105	COG1494	fructose-1,6-bisphosphatase
HC662_RS19110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC662_RS19115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC662_RS19120	COG0191	fructose-bisphosphate aldolase activity
HC662_RS19125	COG2204	response regulator
HC662_RS19130	COG4821	SIS domain
HC662_RS19135	COG0504	CTP synthase activity
HC662_RS19140	COG3343	RNA polymerase activity
HC662_RS19145	COG1960	acyl-CoA dehydrogenase activity
HC662_RS19150	COG0247	lactate metabolic process
HC662_RS19150	COG2181	nitrate reductase activity
HC662_RS19155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC662_RS19160	COG4294	response to UV
HC662_RS19170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC662_RS19175	COG1132	(ABC) transporter
HC662_RS19180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC662_RS19190	COG2181	nitrate reductase activity
HC662_RS19195	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC662_RS19200	COG1140	nitrate reductase beta subunit
HC662_RS19205	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC662_RS19210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC662_RS19220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC662_RS19225	COG2223	nitrite transmembrane transporter activity
HC662_RS19230	COG0018	arginyl-trna synthetase
HC662_RS19235	COG4506	Protein conserved in bacteria
HC662_RS19250	COG0535	radical SAM domain protein
HC662_RS19260	COG1131	(ABC) transporter
HC662_RS19270	COG0612	Peptidase, M16
HC662_RS19285	COG3391	amine dehydrogenase activity
HC662_RS19290	COG3391	amine dehydrogenase activity
HC662_RS19295	COG0457	Tetratricopeptide repeat
HC662_RS19325	COG1131	(ABC) transporter
HC662_RS19335	COG0010	Belongs to the arginase family
HC662_RS19340	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC662_RS19345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC662_RS19400	COG1994	Peptidase M50
HC662_RS19405	COG1942	4-Oxalocrotonate Tautomerase
HC662_RS19410	COG1846	Transcriptional regulator
HC662_RS19415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC662_RS19425	COG0477	Major facilitator Superfamily
HC662_RS19430	COG1959	2 iron, 2 sulfur cluster binding
HC662_RS19435	COG3465	dGTPase activity
HC662_RS19440	COG1078	dGTPase activity
HC662_RS19445	COG4844	belongs to the
HC662_RS19455	COG0697	spore germination
HC662_RS19460	COG0095	Lipoate-protein ligase
HC662_RS19465	COG0583	DNA-binding transcription factor activity
HC662_RS19470	COG0280	phosphate acetyltransferase
HC662_RS19480	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS19485	COG0436	Aminotransferase
HC662_RS19490	COG2814	Major facilitator Superfamily
HC662_RS19495	COG0151	Belongs to the GarS family
HC662_RS19500	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS19505	COG1917	Cupin 2, conserved barrel domain protein
HC662_RS19510	COG0077	Prephenate dehydratase
HC662_RS19515	COG2814	Major facilitator Superfamily
HC662_RS19525	COG4187	Peptidase family M20/M25/M40
HC662_RS19530	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS19535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC662_RS19545	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC662_RS19550	COG1091	dTDP-4-dehydrorhamnose reductase activity
HC662_RS19555	COG1088	dTDP-glucose 4,6-dehydratase activity
HC662_RS19560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC662_RS19570	COG0456	acetyltransferase
HC662_RS19575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC662_RS19580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC662_RS19585	COG0463	Glycosyl transferase, family 2
HC662_RS19595	COG2363	Small membrane protein
HC662_RS19600	COG2233	PERMEase
HC662_RS19610	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS19615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC662_RS19620	COG1216	Glycosyl transferase, family 2
HC662_RS19625	COG0351	phosphomethylpyrimidine kinase
HC662_RS19635	COG1621	beta-fructofuranosidase activity
HC662_RS19640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS19640	COG1263	PTS System
HC662_RS19645	COG2116	formate transmembrane transporter activity
HC662_RS19650	COG3711	transcriptional antiterminator
HC662_RS19660	COG1404	Belongs to the peptidase S8 family
HC662_RS19665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_RS19675	COG0772	Belongs to the SEDS family
HC662_RS19715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HC662_RS19720	COG2837	iron assimilation
HC662_RS19725	COG2822	iron ion transport
HC662_RS19730	COG0672	)-iron permease
HC662_RS19735	COG0352	thiamine-phosphate diphosphorylase activity
HC662_RS19740	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HC662_RS19745	COG0583	DNA-binding transcription factor activity
HC662_RS19750	COG1380	Effector of murein hydrolase LrgA
HC662_RS19755	COG1346	cytolysis
HC662_RS19760	COG2814	Major facilitator Superfamily
HC662_RS19765	COG4895	conserved protein (DUF2196)
HC662_RS19770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HC662_RS19775	COG0346	lactoylglutathione lyase activity
HC662_RS19780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_RS19785	COG1404	Belongs to the peptidase S8 family
HC662_RS19790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS19790	COG1263	PTS System
HC662_RS19795	COG3711	transcriptional antiterminator
HC662_RS19800	COG1442	glycosyl transferase family 8
HC662_RS19805	COG5522	Integral membrane protein (intg_mem_TP0381)
HC662_RS19810	COG1846	Transcriptional regulator
HC662_RS19815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC662_RS19820	COG2234	aminopeptidase activity
HC662_RS19835	COG2814	Major facilitator Superfamily
HC662_RS19840	COG2357	RelA SpoT domain protein
HC662_RS19845	COG1575	Belongs to the MenA family. Type 1 subfamily
HC662_RS19860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_RS19865	COG1696	Membrane protein involved in D-alanine export
HC662_RS19870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_RS19875	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HC662_RS19880	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HC662_RS19885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC662_RS19890	COG1486	melibiose metabolic process
HC662_RS19895	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC662_RS19900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_RS19905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_RS19910	COG3711	transcriptional antiterminator
HC662_RS19910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_RS19920	COG2094	Belongs to the DNA glycosylase MPG family
HC662_RS19925	COG0753	catalase activity
HC662_RS19930	COG2814	Major facilitator Superfamily
HC662_RS19935	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC662_RS19940	COG1131	(ABC) transporter
HC662_RS19960	COG1595	DNA-templated transcription, initiation
HC662_RS19965	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC662_RS19970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC662_RS19975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC662_RS19980	COG4988	ABC transporter
HC662_RS19985	COG1294	oxidase, subunit
HC662_RS19990	COG1271	oxidase subunit
HC662_RS19995	COG3493	citrate carrier protein
HC662_RS20000	COG0501	Belongs to the peptidase M48B family
HC662_RS20010	COG0726	polysaccharide deacetylase
HC662_RS20020	COG3842	ATPase activity
HC662_RS20025	COG2508	Transcriptional regulator
HC662_RS20030	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS20035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_RS20045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HC662_RS20055	COG2197	response regulator
HC662_RS20060	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC662_RS20070	COG4894	glucomannan catabolic process
HC662_RS20075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC662_RS20080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC662_RS20085	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS20090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC662_RS20095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC662_RS20100	COG2610	gluconate transmembrane transporter activity
HC662_RS20105	COG0500	methyltransferase
HC662_RS20110	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS20115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC662_RS20130	COG0753	catalase activity
HC662_RS20130	COG0693	protein deglycase activity
HC662_RS20135	COG2851	Citrate transporter
HC662_RS20140	COG2323	membrane
HC662_RS20150	COG2273	Hydrolase Family 16
HC662_RS20155	COG2723	6-phospho-beta-galactosidase activity
HC662_RS20160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS20160	COG1263	PTS System
HC662_RS20160	COG2190	(PTS) system
HC662_RS20165	COG3711	transcriptional antiterminator
HC662_RS20175	COG2270	Major facilitator Superfamily
HC662_RS20180	COG0513	Belongs to the DEAD box helicase family
HC662_RS20185	COG3401	FG-GAP repeat protein
HC662_RS20185	COG2755	lipolytic protein G-D-S-L family
HC662_RS20270	COG0697	spore germination
HC662_RS20280	COG0861	Integral membrane protein TerC family
HC662_RS20285	COG0589	response to stress
HC662_RS20290	COG2723	6-phospho-beta-galactosidase activity
HC662_RS20295	COG2190	(PTS) system
HC662_RS20295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_RS20295	COG1263	PTS System
HC662_RS20335	COG5444	nuclease activity
HC662_RS20370	COG3507	Belongs to the glycosyl hydrolase 43 family
HC662_RS20385	COG2986	histidine ammonia-lyase
HC662_RS20390	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HC662_RS20395	COG1228	amidohydrolase
HC662_RS20400	COG0010	Belongs to the arginase family
HC662_RS20405	COG0833	amino acid
HC662_RS20410	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HC662_RS20415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC662_RS20420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HC662_RS20425	COG2390	Transcriptional regulator
HC662_RS20435	COG3192	ethanolamine utilization protein
HC662_RS20440	COG2079	MmgE PrpD family protein
HC662_RS20445	COG1473	amidohydrolase
HC662_RS20450	COG1126	abc transporter atp-binding protein
HC662_RS20455	COG0765	amino acid transport
HC662_RS20460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_RS20465	COG0456	acetyltransferase
HC662_RS20470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_RS20475	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC662_RS20485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_RS20490	COG0456	acetyltransferase
HC662_RS20495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_RS20500	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC662_RS20505	COG0561	phosphatase activity
HC662_RS20530	COG5294	Protein conserved in bacteria
HC662_RS20535	COG0577	efflux transmembrane transporter activity
HC662_RS20540	COG1136	(ABC) transporter
HC662_RS20545	COG2205	protein histidine kinase activity
HC662_RS20550	COG0745	RESPONSE REGULATOR receiver
HC662_RS20560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_RS20565	COG0191	fructose-bisphosphate aldolase activity
HC662_RS20570	COG1082	Xylose isomerase domain protein TIM barrel
HC662_RS20575	COG1082	Xylose isomerase domain protein TIM barrel
HC662_RS20580	COG0673	inositol 2-dehydrogenase activity
HC662_RS20585	COG2814	Major facilitator Superfamily
HC662_RS20590	COG1082	Xylose isomerase domain protein TIM barrel
HC662_RS20595	COG3962	Belongs to the TPP enzyme family
HC662_RS20600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_RS20610	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS20615	COG1349	DNA-binding transcription factor activity
HC662_RS20620	COG0667	Aldo Keto reductase
HC662_RS20645	COG2814	Major facilitator Superfamily
HC662_RS20650	COG0326	Molecular chaperone. Has ATPase activity
HC662_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_RS20665	COG1309	transcriptional regulator
HC662_RS20670	COG1012	belongs to the aldehyde dehydrogenase family
HC662_RS20675	COG1714	RDD family
HC662_RS20680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC662_RS20690	COG1714	RDD family
HC662_RS20695	COG2311	Membrane
HC662_RS20700	COG1917	Cupin 2, conserved barrel domain protein
HC662_RS20705	COG1309	transcriptional regulator
HC662_RS20715	COG1846	Transcriptional regulator
HC662_RS20720	COG1380	Effector of murein hydrolase LrgA
HC662_RS20725	COG1346	cytolysis
HC662_RS20730	COG5039	Polysaccharide pyruvyl transferase
HC662_RS20735	COG1929	Belongs to the glycerate kinase type-1 family
HC662_RS20740	COG1802	Transcriptional regulator
HC662_RS20745	COG1070	Carbohydrate kinase
HC662_RS20750	COG2610	gluconate transmembrane transporter activity
HC662_RS20755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC662_RS20760	COG0450	alkyl hydroperoxide reductase
HC662_RS20765	COG3634	alkyl hydroperoxide reductase activity
HC662_RS20790	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HC662_RS20795	COG0419	ATPase involved in DNA repair
HC662_RS20810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HC662_RS20825	COG1063	alcohol dehydrogenase
HC662_RS20845	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HC662_RS20850	COG0456	acetyltransferase
HC662_RS20855	COG0457	Tetratricopeptide repeat
HC662_RS20865	COG0010	Belongs to the arginase family
HC662_RS20870	COG0833	amino acid
HC662_RS20875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC662_RS20895	COG5658	integral membrane protein
HC662_RS20900	COG0640	Transcriptional regulator
HC662_RS20905	COG3829	transcription factor binding
HC662_RS20910	COG5002	protein histidine kinase activity
HC662_RS20925	COG3212	peptidase
HC662_RS20930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC662_RS20935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC662_RS20940	COG4853	Protein conserved in bacteria
HC662_RS20945	COG4863	YycH protein
HC662_RS20950	COG5002	protein histidine kinase activity
HC662_RS20955	COG0745	RESPONSE REGULATOR receiver
HC662_RS20985	COG0346	lactoylglutathione lyase activity
HC662_RS20990	COG0305	Participates in initiation and elongation during chromosome replication
HC662_RS21005	COG3093	addiction module antidote protein HigA
HC662_RS21010	COG2807	transmembrane transport
HC662_RS21015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC662_RS21020	COG0359	binds to the 23S rRNA
HC662_RS21025	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HC662_RS21030	COG4241	membrane
HC662_RS21040	COG5577	PFAM Coat F domain
HC662_RS21045	COG1733	regulation of RNA biosynthetic process
HC662_RS21050	COG1227	inorganic diphosphatase activity
HC662_RS21060	COG2271	Major facilitator Superfamily
HC662_RS21075	COG1357	PFAM Pentapeptide repeats (8 copies)
HC662_RS21080	COG2814	Major facilitator Superfamily
HC662_RS21085	COG0583	DNA-binding transcription factor activity
HC662_RS21090	COG2153	protein acetylation
HC662_RS21105	COG1846	Transcriptional regulator
HC662_RS21110	COG2153	protein acetylation
HC662_RS21115	COG2364	Membrane
HC662_RS21135	COG1331	Highly conserved protein containing a thioredoxin domain
HC662_RS21140	COG1846	Transcriptional regulator
HC662_RS21145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_RS21160	COG0789	Transcriptional regulator
HC662_RS21165	COG0697	spore germination
HC662_RS21170	COG1331	Highly conserved protein containing a thioredoxin domain
HC662_RS21175	COG1266	CAAX protease self-immunity
HC662_RS21180	COG2814	Major facilitator Superfamily
HC662_RS21180	COG0477	Major facilitator Superfamily
HC662_RS21185	COG0346	lactoylglutathione lyase activity
HC662_RS21190	COG1609	Transcriptional regulator
HC662_RS21195	COG0708	Exodeoxyribonuclease III
HC662_RS21200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC662_RS21205	COG0629	single-stranded DNA binding
HC662_RS21210	COG0360	Binds together with S18 to 16S ribosomal RNA
HC662_RS21215	COG0012	GTP binding
HC662_RS21220	COG0243	molybdopterin cofactor binding
HC662_RS21225	COG4481	Protein conserved in bacteria
HC662_RS21230	COG3949	Membrane
HC662_RS21245	COG1475	DNA binding
HC662_RS21250	COG1192	Involved in chromosome partitioning
HC662_RS21260	COG1475	DNA binding
HC662_RS21265	COG0357	Ribosomal RNA small subunit methyltransferase G
HC662_RS21270	COG0445	tRNA wobble uridine modification
HC662_RS21275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HC662_RS21280	COG1847	R3H domain protein
HC662_RS21285	COG0706	membrane insertase activity
HC662_RS21290	COG0594	ribonuclease P activity