locus-tag	class	description
B4071_RS00005	COG0726	polysaccharide deacetylase
B4071_RS00010	COG2194	sulfuric ester hydrolase activity
B4071_RS00020	COG0489	protein tyrosine kinase activity
B4071_RS00025	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4071_RS00035	COG2226	methyltransferase
B4071_RS00045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B4071_RS00050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B4071_RS00055	COG0101	tRNA pseudouridine synthase activity
B4071_RS00060	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4071_RS00065	COG1122	ATPase activity
B4071_RS00070	COG1122	ATPase activity
B4071_RS00075	COG0203	ribosomal protein L17
B4071_RS00080	COG0202	RNA polymerase activity
B4071_RS00085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B4071_RS00090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B4071_RS00095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4071_RS00105	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B4071_RS00110	COG0024	Methionine aminopeptidase
B4071_RS00115	COG0563	adenylate kinase activity
B4071_RS00120	COG0201	protein transport
B4071_RS00125	COG0200	Binds to the 23S rRNA
B4071_RS00135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B4071_RS00140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B4071_RS00145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B4071_RS00150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B4071_RS00160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B4071_RS00175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B4071_RS00185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B4071_RS00190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B4071_RS00205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B4071_RS00215	COG0088	Forms part of the polypeptide exit tunnel
B4071_RS00220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B4071_RS00230	COG0596	Alpha beta hydrolase
B4071_RS00235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4071_RS00240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B4071_RS00245	COG0049	tRNA binding
B4071_RS00250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B4071_RS00255	COG1358	cellular component organization or biogenesis
B4071_RS00260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B4071_RS00265	COG0085	RNA polymerase activity
B4071_RS00270	COG2813	Specifically methylates the guanine in position
B4071_RS00280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B4071_RS00285	COG0081	regulation of translation
B4071_RS00295	COG0250	Participates in transcription elongation, termination and antitermination
B4071_RS00300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4071_RS00310	COG1595	DNA-templated transcription, initiation
B4071_RS00315	COG3688	RNA-binding protein containing a PIN domain
B4071_RS00320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4071_RS00325	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B4071_RS00330	COG0215	cysteine-tRNA ligase activity
B4071_RS00335	COG1045	serine acetyltransferase
B4071_RS00345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B4071_RS00350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B4071_RS00355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B4071_RS00360	COG4956	integral membrane protein (PIN domain superfamily)
B4071_RS00365	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B4071_RS00370	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4071_RS00375	COG0542	response to heat
B4071_RS00380	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B4071_RS00385	COG3880	PFAM UvrB UvrC protein
B4071_RS00390	COG4463	regulation of RNA biosynthetic process
B4071_RS00405	COG0131	Imidazoleglycerol-phosphate dehydratase
B4071_RS00425	COG0457	Tetratricopeptide repeat
B4071_RS00445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4071_RS00450	COG0670	Belongs to the BI1 family
B4071_RS00455	COG5583	Uncharacterized small protein (DUF2292)
B4071_RS00470	COG0346	lactoylglutathione lyase activity
B4071_RS00480	COG2323	membrane
B4071_RS00485	COG1486	melibiose metabolic process
B4071_RS00490	COG0395	ABC-type sugar transport system, permease component
B4071_RS00495	COG4209	transmembrane transport
B4071_RS00500	COG1653	transport
B4071_RS00510	COG1874	Beta-galactosidase
B4071_RS00515	COG2755	lipolytic protein G-D-S-L family
B4071_RS00520	COG3401	FG-GAP repeat protein
B4071_RS00525	COG3401	FG-GAP repeat protein
B4071_RS00530	COG5578	integral membrane protein
B4071_RS00540	COG2755	lipolytic protein G-D-S-L family
B4071_RS00545	COG2207	Transcriptional regulator
B4071_RS00550	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B4071_RS00560	COG1175	transmembrane transport
B4071_RS00565	COG1653	transport
B4071_RS00575	COG2972	Histidine kinase
B4071_RS00580	COG5578	integral membrane protein
B4071_RS00590	COG0454	-acetyltransferase
B4071_RS00595	COG3546	catalase activity
B4071_RS00610	COG1309	transcriptional regulator
B4071_RS00620	COG0217	transcriptional regulatory protein
B4071_RS00630	COG0457	Tetratricopeptide repeat
B4071_RS00640	COG5444	nuclease activity
B4071_RS00660	COG0457	Tetratricopeptide repeat
B4071_RS00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4071_RS00675	COG1597	lipid kinase activity
B4071_RS00680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4071_RS00685	COG1309	transcriptional regulator
B4071_RS00690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4071_RS00695	COG0154	amidase activity
B4071_RS00700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4071_RS00705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4071_RS00710	COG1285	pathogenesis
B4071_RS00715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4071_RS00735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4071_RS00775	COG0735	belongs to the Fur family
B4071_RS00780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4071_RS00785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4071_RS00790	COG4129	membrane
B4071_RS00795	COG1132	(ABC) transporter
B4071_RS00800	COG3557	Belongs to the UPF0374 family
B4071_RS00815	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS00825	COG1194	a g-specific adenine glycosylase
B4071_RS00830	COG1988	membrane-bound metal-dependent
B4071_RS00835	COG4485	Bacterial membrane protein, YfhO
B4071_RS00840	COG0463	Glycosyl transferase, family 2
B4071_RS00845	COG0596	Alpha beta hydrolase
B4071_RS00850	COG5658	integral membrane protein
B4071_RS00855	COG3103	Sh3 type 3 domain protein
B4071_RS00870	COG2814	Major facilitator Superfamily
B4071_RS00885	COG2137	regulation of response to DNA damage stimulus
B4071_RS00890	COG1090	epimerase
B4071_RS00905	COG0778	Nitroreductase
B4071_RS00910	COG0384	phenazine biosynthesis protein PhzF
B4071_RS00915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS00920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS00925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4071_RS00930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B4071_RS00930	COG0392	lysyltransferase activity
B4071_RS00935	COG1846	Transcriptional regulator
B4071_RS00940	COG2814	Major facilitator Superfamily
B4071_RS00945	COG2318	DinB family
B4071_RS00950	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B4071_RS00955	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B4071_RS00960	COG1695	Transcriptional regulator
B4071_RS00970	COG0842	Transport permease protein
B4071_RS00975	COG1511	domain protein
B4071_RS00975	COG0842	Transport permease protein
B4071_RS00980	COG1131	(ABC) transporter
B4071_RS00985	COG2197	response regulator
B4071_RS00990	COG4585	Histidine kinase
B4071_RS00995	COG0673	inositol 2-dehydrogenase activity
B4071_RS01000	COG1082	Xylose isomerase domain protein TIM barrel
B4071_RS01005	COG2814	Major facilitator Superfamily
B4071_RS01010	COG1917	Cupin 2, conserved barrel domain protein
B4071_RS01010	COG4977	sequence-specific DNA binding
B4071_RS01015	COG2514	catechol 2,3-dioxygenase activity
B4071_RS01020	COG2259	Doxx family
B4071_RS01025	COG1132	(ABC) transporter
B4071_RS01030	COG1132	(ABC) transporter
B4071_RS01035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4071_RS01035	COG1263	PTS System
B4071_RS01040	COG1737	Transcriptional regulator
B4071_RS01045	COG1486	melibiose metabolic process
B4071_RS01050	COG4842	Belongs to the WXG100 family
B4071_RS01070	COG1742	UPF0060 membrane protein
B4071_RS01080	COG3284	Transcriptional regulator
B4071_RS01085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4071_RS01090	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4071_RS01095	COG0022	dehydrogenase e1 component
B4071_RS01100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4071_RS01110	COG4637	Psort location Cytoplasmic, score
B4071_RS01115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4071_RS01130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4071_RS01135	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4071_RS01140	COG0598	Magnesium transport protein CorA
B4071_RS01145	COG2084	Dehydrogenase
B4071_RS01150	COG0726	polysaccharide deacetylase
B4071_RS01160	COG0535	radical SAM domain protein
B4071_RS01165	COG0668	transmembrane transport
B4071_RS01175	COG0387	Pfam Sodium calcium exchanger
B4071_RS01185	COG0477	Major facilitator Superfamily
B4071_RS01195	COG1295	ribonuclease BN
B4071_RS01200	COG4980	gas vesicle protein
B4071_RS01205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4071_RS01210	COG4840	Belongs to the UPF0435 family
B4071_RS01215	COG2814	Major facilitator Superfamily
B4071_RS01220	COG0693	protein deglycase activity
B4071_RS01225	COG0737	Belongs to the 5'-nucleotidase family
B4071_RS01230	COG0778	Nitroreductase
B4071_RS01235	COG2188	Transcriptional regulator
B4071_RS01240	COG0366	Alpha amylase catalytic
B4071_RS01245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4071_RS01245	COG1263	PTS System
B4071_RS01250	COG0697	spore germination
B4071_RS01260	COG1368	sulfuric ester hydrolase activity
B4071_RS01265	COG1263	PTS System
B4071_RS01265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4071_RS01270	COG0024	Methionine aminopeptidase
B4071_RS01290	COG2258	MOSC domain
B4071_RS01295	COG1254	Belongs to the acylphosphatase family
B4071_RS01300	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B4071_RS01305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4071_RS01310	COG2851	Citrate transporter
B4071_RS01320	COG3181	Tripartite tricarboxylate transporter family receptor
B4071_RS01325	COG4565	transcriptional regulatory protein
B4071_RS01330	COG3290	protein histidine kinase activity
B4071_RS01335	COG0471	metal ion transport
B4071_RS01340	COG3866	Pectate lyase
B4071_RS01355	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4071_RS01360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS01365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS01370	COG1120	ATPase activity
B4071_RS01375	COG2130	NADP-dependent
B4071_RS01380	COG0456	acetyltransferase
B4071_RS01385	COG0513	Belongs to the DEAD box helicase family
B4071_RS01390	COG0488	(ABC) transporter
B4071_RS01395	COG0569	domain protein
B4071_RS01400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4071_RS01405	COG4682	membrane
B4071_RS01410	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4071_RS01415	COG0477	Major facilitator Superfamily
B4071_RS01420	COG5553	Cysteine dioxygenase type I
B4071_RS01430	COG1968	undecaprenyl-diphosphatase activity
B4071_RS01435	COG0628	permease
B4071_RS01440	COG0673	inositol 2-dehydrogenase activity
B4071_RS01445	COG4806	L-rhamnose isomerase
B4071_RS01450	COG3254	rhamnose metabolic process
B4071_RS01455	COG1070	Carbohydrate kinase
B4071_RS01460	COG1349	DNA-binding transcription factor activity
B4071_RS01465	COG3347	Dehydrogenase
B4071_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS01470	COG0840	transmembrane signaling receptor activity
B4071_RS01475	COG0840	transmembrane signaling receptor activity
B4071_RS01480	COG0840	transmembrane signaling receptor activity
B4071_RS01485	COG0840	transmembrane signaling receptor activity
B4071_RS01500	COG0432	Pfam Uncharacterised protein family UPF0047
B4071_RS01510	COG1253	flavin adenine dinucleotide binding
B4071_RS01515	COG2738	Putative neutral zinc metallopeptidase
B4071_RS01530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4071_RS01545	COG0166	Belongs to the GPI family
B4071_RS01550	COG1979	alcohol dehydrogenase
B4071_RS01555	COG1979	alcohol dehydrogenase
B4071_RS01560	COG2155	Conserved Protein
B4071_RS01565	COG1098	S1 RNA binding domain
B4071_RS01570	COG0436	Aminotransferase
B4071_RS01575	COG1522	sequence-specific DNA binding
B4071_RS01580	COG2267	carboxylic ester hydrolase activity
B4071_RS01590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B4071_RS01595	COG2205	protein histidine kinase activity
B4071_RS01605	COG5018	Exonuclease
B4071_RS01615	COG2814	Major facilitator Superfamily
B4071_RS01620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4071_RS01625	COG3011	Protein conserved in bacteria
B4071_RS01635	COG3290	protein histidine kinase activity
B4071_RS01640	COG4565	transcriptional regulatory protein
B4071_RS01645	COG1744	ABC transporter substrate-binding protein PnrA-like
B4071_RS01650	COG3845	ABC transporter
B4071_RS01655	COG4603	Belongs to the binding-protein-dependent transport system permease family
B4071_RS01660	COG1079	Belongs to the binding-protein-dependent transport system permease family
B4071_RS01665	COG3493	citrate carrier protein
B4071_RS01675	COG2111	Na H antiporter
B4071_RS01675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4071_RS01680	COG2111	Na H antiporter
B4071_RS01685	COG1006	Multisubunit Na H antiporter MnhC subunit
B4071_RS01690	COG0651	ATP synthesis coupled electron transport
B4071_RS01695	COG1863	multisubunit Na H antiporter MnhE subunit
B4071_RS01700	COG2212	antiporter activity
B4071_RS01705	COG1320	monovalent cation:proton antiporter activity
B4071_RS01710	COG2050	protein possibly involved in aromatic compounds catabolism
B4071_RS01715	COG2197	response regulator
B4071_RS01720	COG4585	Histidine kinase
B4071_RS01730	COG0142	geranyltranstransferase activity
B4071_RS01745	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B4071_RS01750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B4071_RS01755	COG1335	isochorismatase
B4071_RS01760	COG5506	Protein of unknown function (DUF1694)
B4071_RS01775	COG0628	permease
B4071_RS01790	COG1418	mRNA catabolic process
B4071_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS01805	COG1511	domain protein
B4071_RS01810	COG1674	ftsk spoiiie
B4071_RS01810	COG0433	COG0433 Predicted ATPase
B4071_RS01815	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4071_RS01820	COG5417	Belongs to the EsaB family
B4071_RS01825	COG4842	Belongs to the WXG100 family
B4071_RS01830	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B4071_RS01830	COG2508	Transcriptional regulator
B4071_RS01835	COG0686	Belongs to the AlaDH PNT family
B4071_RS01840	COG5634	Uncharacterized conserved protein (DUF2278)
B4071_RS01845	COG3251	PFAM MbtH domain protein
B4071_RS01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4071_RS01855	COG3433	isochorismatase activity
B4071_RS01855	COG1535	isochorismatase
B4071_RS01860	COG1021	2,3-dihydroxybenzoate-AMP ligase
B4071_RS01865	COG1169	isochorismate synthase
B4071_RS01870	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS01875	COG2819	hydrolase of the alpha beta superfamily
B4071_RS01880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4071_RS01885	COG1268	BioY protein
B4071_RS01890	COG2056	Na+-H+ antiporter family
B4071_RS01895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4071_RS01900	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B4071_RS01905	COG3584	3D domain protein
B4071_RS01920	COG1252	NADH dehydrogenase
B4071_RS01925	COG0492	ferredoxin-NADP+ reductase activity
B4071_RS01935	COG0516	GMP reductase activity
B4071_RS01940	COG2808	Putative FMN-binding domain
B4071_RS01950	COG0316	Belongs to the HesB IscA family
B4071_RS01955	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B4071_RS01960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4071_RS01965	COG4844	belongs to the
B4071_RS01970	COG1252	NADH dehydrogenase
B4071_RS01975	COG4837	Protein of unknown function (DUF1462)
B4071_RS01980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4071_RS01985	COG4946	Tricorn protease homolog
B4071_RS01985	COG0823	Involved in the tonB-independent uptake of proteins
B4071_RS01985	COG1506	peptidase
B4071_RS01990	COG0083	homoserine kinase activity
B4071_RS01995	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4071_RS02000	COG0460	homoserine dehydrogenase
B4071_RS02005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4071_RS02010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4071_RS02015	COG0647	UMP catabolic process
B4071_RS02020	COG2445	Protein of unknown function DUF86
B4071_RS02025	COG4470	Protein conserved in bacteria
B4071_RS02035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B4071_RS02040	COG0739	heme binding
B4071_RS02050	COG3377	Domain of unknown function (DUF1805)
B4071_RS02055	COG0737	Belongs to the 5'-nucleotidase family
B4071_RS02060	COG0730	response to heat
B4071_RS02065	COG1801	Protein of unknown function DUF72
B4071_RS02075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4071_RS02080	COG2508	Transcriptional regulator
B4071_RS02085	COG2233	PERMEase
B4071_RS02090	COG2233	PERMEase
B4071_RS02095	COG3195	allantoin biosynthetic process
B4071_RS02095	COG3648	Uricase
B4071_RS02100	COG2351	hydroxyisourate hydrolase activity
B4071_RS02110	COG2080	2 iron, 2 sulfur cluster binding
B4071_RS02115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B4071_RS02120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B4071_RS02125	COG2068	MobA-Related Protein
B4071_RS02130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B4071_RS02135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4071_RS02140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4071_RS02150	COG2356	endonuclease I
B4071_RS02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4071_RS02175	COG0072	phenylalanine-tRNA ligase activity
B4071_RS02175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4071_RS02190	COG3842	ATPase activity
B4071_RS02195	COG2188	Transcriptional regulator
B4071_RS02200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4071_RS02215	COG2222	sugar isomerase
B4071_RS02220	COG0322	excinuclease ABC activity
B4071_RS02225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4071_RS02250	COG0346	lactoylglutathione lyase activity
B4071_RS02255	COG0640	Transcriptional regulator
B4071_RS02260	COG0719	Fe-S assembly protein
B4071_RS02265	COG0822	iron-sulfur transferase activity
B4071_RS02270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4071_RS02275	COG0719	Fe-S assembly protein
B4071_RS02280	COG0396	ATPase activity
B4071_RS02295	COG1464	Belongs to the NlpA lipoprotein family
B4071_RS02300	COG2011	ABC-type metal ion transport system permease component
B4071_RS02305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4071_RS02315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS02320	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4071_RS02330	COG0509	glycine decarboxylation via glycine cleavage system
B4071_RS02335	COG1393	Belongs to the ArsC family
B4071_RS02340	COG1960	acyl-CoA dehydrogenase activity
B4071_RS02345	COG0183	Belongs to the thiolase family
B4071_RS02350	COG1024	Enoyl-CoA hydratase
B4071_RS02350	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4071_RS02360	COG0506	proline dehydrogenase activity
B4071_RS02370	COG5577	PFAM Coat F domain
B4071_RS02375	COG1846	Transcriptional regulator
B4071_RS02380	COG0477	Major facilitator Superfamily
B4071_RS02385	COG1942	4-Oxalocrotonate Tautomerase
B4071_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS02395	COG0583	DNA-binding transcription factor activity
B4071_RS02405	COG1120	ATPase activity
B4071_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS02425	COG0783	Belongs to the Dps family
B4071_RS02430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4071_RS02435	COG0745	RESPONSE REGULATOR receiver
B4071_RS02440	COG2205	protein histidine kinase activity
B4071_RS02440	COG2770	Histidine kinase
B4071_RS02450	COG1309	transcriptional regulator
B4071_RS02455	COG0114	fumarate hydratase activity
B4071_RS02465	COG0697	spore germination
B4071_RS02470	COG0814	amino acid
B4071_RS02480	COG2197	response regulator
B4071_RS02485	COG4585	Histidine kinase
B4071_RS02490	COG4758	membrane
B4071_RS02495	COG3595	metallopeptidase activity
B4071_RS02500	COG1842	Phage shock protein A
B4071_RS02505	COG4758	membrane
B4071_RS02510	COG2814	Major facilitator Superfamily
B4071_RS02515	COG2096	Adenosyltransferase
B4071_RS02520	COG1120	ATPase activity
B4071_RS02525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS02530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4071_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS02545	COG3386	PFAM SMP-30 Gluconolaconase
B4071_RS02550	COG2205	protein histidine kinase activity
B4071_RS02555	COG0745	RESPONSE REGULATOR receiver
B4071_RS02565	COG1191	sigma factor activity
B4071_RS02575	COG2140	Oxalate decarboxylase
B4071_RS02585	COG0577	efflux transmembrane transporter activity
B4071_RS02590	COG1136	(ABC) transporter
B4071_RS02595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4071_RS02600	COG1120	ATPase activity
B4071_RS02605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS02610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS02615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4071_RS02625	COG0531	amino acid
B4071_RS02635	COG1988	membrane-bound metal-dependent
B4071_RS02640	COG1368	sulfuric ester hydrolase activity
B4071_RS02645	COG1910	domain protein
B4071_RS02650	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4071_RS02655	COG4149	molybdate abc transporter
B4071_RS02660	COG0656	L-ascorbic acid biosynthetic process
B4071_RS02670	COG0025	NhaP-type Na H and K H
B4071_RS02675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4071_RS02680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4071_RS02685	COG3973	AAA domain
B4071_RS02690	COG2860	membrane
B4071_RS02695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4071_RS02700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B4071_RS02705	COG2217	Heavy metal translocating P-type atpase
B4071_RS02710	COG2217	Heavy metal translocating P-type atpase
B4071_RS02715	COG2608	mercury ion transmembrane transporter activity
B4071_RS02720	COG1937	Protein conserved in bacteria
B4071_RS02725	COG0673	inositol 2-dehydrogenase activity
B4071_RS02730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4071_RS02735	COG1289	transmembrane transporter activity
B4071_RS02745	COG2076	Multidrug Resistance protein
B4071_RS02750	COG1309	transcriptional regulator
B4071_RS02755	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS02760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B4071_RS02765	COG0557	exoribonuclease II activity
B4071_RS02770	COG1647	Serine aminopeptidase, S33
B4071_RS02775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4071_RS02780	COG0596	Alpha beta hydrolase
B4071_RS02785	COG1476	TRANSCRIPTIONal
B4071_RS02790	COG1396	sequence-specific DNA binding
B4071_RS02795	COG1396	sequence-specific DNA binding
B4071_RS02800	COG1733	regulation of RNA biosynthetic process
B4071_RS02810	COG1174	glycine betaine transport
B4071_RS02815	COG1732	Glycine betaine
B4071_RS02820	COG1174	glycine betaine transport
B4071_RS02825	COG1125	glycine betaine transport
B4071_RS02825	COG0517	IMP dehydrogenase activity
B4071_RS02830	COG1510	regulation of RNA biosynthetic process
B4071_RS02850	COG5658	integral membrane protein
B4071_RS02855	COG0640	Transcriptional regulator
B4071_RS02860	COG1174	glycine betaine transport
B4071_RS02865	COG1732	Glycine betaine
B4071_RS02870	COG1174	glycine betaine transport
B4071_RS02875	COG0517	IMP dehydrogenase activity
B4071_RS02875	COG1125	glycine betaine transport
B4071_RS02880	COG1510	regulation of RNA biosynthetic process
B4071_RS02885	COG2095	MarC family integral membrane protein
B4071_RS02895	COG3064	Membrane
B4071_RS02900	COG4640	response to antibiotic
B4071_RS02905	COG0456	acetyltransferase
B4071_RS02910	COG0148	phosphopyruvate hydratase activity
B4071_RS02915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B4071_RS02920	COG0149	triose-phosphate isomerase activity
B4071_RS02925	COG0126	phosphoglycerate kinase activity
B4071_RS02935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4071_RS02940	COG2390	Transcriptional regulator
B4071_RS02945	COG2814	Major facilitator Superfamily
B4071_RS02950	COG1609	Transcriptional regulator
B4071_RS02955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4071_RS02960	COG0583	DNA-binding transcription factor activity
B4071_RS02965	COG0697	spore germination
B4071_RS02970	COG1113	amino acid transport
B4071_RS02975	COG3858	chitin binding
B4071_RS02980	COG1556	Lactate utilization protein
B4071_RS02985	COG1139	Iron-sulfur cluster binding protein
B4071_RS02990	COG0247	lactate metabolic process
B4071_RS03005	COG2197	response regulator
B4071_RS03010	COG4585	Histidine kinase
B4071_RS03015	COG0842	Transport permease protein
B4071_RS03020	COG1131	(ABC) transporter
B4071_RS03025	COG0596	Alpha beta hydrolase
B4071_RS03030	COG2208	phosphoserine phosphatase activity
B4071_RS03035	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B4071_RS03040	COG1874	Beta-galactosidase
B4071_RS03045	COG3833	ABC-type maltose transport systems, permease component
B4071_RS03050	COG1175	transmembrane transport
B4071_RS03055	COG2182	Extracellular solute-binding protein
B4071_RS03060	COG1609	Transcriptional regulator
B4071_RS03065	COG2186	Transcriptional regulator
B4071_RS03070	COG1620	l-lactate permease
B4071_RS03075	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B4071_RS03085	COG5039	Polysaccharide pyruvyl transferase
B4071_RS03090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4071_RS03095	COG0110	maltose O-acetyltransferase activity
B4071_RS03100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4071_RS03105	COG2244	polysaccharide biosynthetic process
B4071_RS03110	COG1216	Glycosyl transferase, family 2
B4071_RS03115	COG5039	Polysaccharide pyruvyl transferase
B4071_RS03120	COG1216	Glycosyl transferase, family 2
B4071_RS03130	COG0438	transferase activity, transferring glycosyl groups
B4071_RS03135	COG1215	transferase activity, transferring glycosyl groups
B4071_RS03140	COG0438	transferase activity, transferring glycosyl groups
B4071_RS03145	COG1086	Polysaccharide biosynthesis protein
B4071_RS03150	COG0489	protein tyrosine kinase activity
B4071_RS03155	COG3944	biosynthesis protein
B4071_RS03160	COG1396	sequence-specific DNA binding
B4071_RS03165	COG2272	Belongs to the type-B carboxylesterase lipase family
B4071_RS03175	COG3479	Phenolic acid decarboxylase
B4071_RS03185	COG1794	racemase activity, acting on amino acids and derivatives
B4071_RS03190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4071_RS03195	COG1621	beta-fructofuranosidase activity
B4071_RS03200	COG1621	beta-fructofuranosidase activity
B4071_RS03205	COG0531	amino acid
B4071_RS03210	COG1309	transcriptional regulator
B4071_RS03215	COG2076	Multidrug Resistance protein
B4071_RS03220	COG2076	Multidrug Resistance protein
B4071_RS03235	COG0740	serine-type endopeptidase activity
B4071_RS03240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4071_RS03245	COG0366	Alpha amylase catalytic
B4071_RS03250	COG1554	hydrolase, family 65, central catalytic
B4071_RS03255	COG5521	maltodextrose utilization protein MalA
B4071_RS03260	COG3833	ABC-type maltose transport systems, permease component
B4071_RS03265	COG1175	transmembrane transport
B4071_RS03270	COG2182	Extracellular solute-binding protein
B4071_RS03275	COG0366	Alpha amylase catalytic
B4071_RS03280	COG1609	Transcriptional regulator
B4071_RS03285	COG1611	Belongs to the LOG family
B4071_RS03290	COG1694	Mazg nucleotide pyrophosphohydrolase
B4071_RS03295	COG0659	secondary active sulfate transmembrane transporter activity
B4071_RS03300	COG0288	reversible hydration of carbon dioxide
B4071_RS03305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4071_RS03315	COG1136	(ABC) transporter
B4071_RS03320	COG5002	protein histidine kinase activity
B4071_RS03325	COG0745	RESPONSE REGULATOR receiver
B4071_RS03335	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B4071_RS03340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4071_RS03345	COG1481	regulation of sporulation
B4071_RS03350	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4071_RS03355	COG1660	Displays ATPase and GTPase activities
B4071_RS03360	COG1051	belongs to the nudix hydrolase family
B4071_RS03365	COG0492	ferredoxin-NADP+ reductase activity
B4071_RS03370	COG3883	PFAM NLP P60 protein
B4071_RS03370	COG0791	NLP P60 protein
B4071_RS03375	COG0457	Tetratricopeptide repeat
B4071_RS03380	COG1132	(ABC) transporter
B4071_RS03400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4071_RS03400	COG0140	phosphoribosyl-ATP diphosphatase activity
B4071_RS03405	COG0107	imidazoleglycerol-phosphate synthase activity
B4071_RS03410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B4071_RS03415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B4071_RS03420	COG0131	Imidazoleglycerol-phosphate dehydratase
B4071_RS03425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B4071_RS03430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B4071_RS03435	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B4071_RS03440	COG4990	cell redox homeostasis
B4071_RS03445	COG5297	Belongs to the glycosyl hydrolase family 6
B4071_RS03450	COG0110	maltose O-acetyltransferase activity
B4071_RS03455	COG0546	phosphoglycolate phosphatase activity
B4071_RS03460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B4071_RS03465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B4071_RS03470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B4071_RS03475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4071_RS03480	COG0363	glucosamine-6-phosphate deaminase activity
B4071_RS03485	COG2188	Transcriptional regulator
B4071_RS03490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4071_RS03495	COG1846	Transcriptional regulator
B4071_RS03500	COG2124	cytochrome p450
B4071_RS03510	COG1846	Transcriptional regulator
B4071_RS03515	COG2814	Major facilitator Superfamily
B4071_RS03520	COG1950	PFAM Membrane protein of
B4071_RS03525	COG1983	PspC domain protein
B4071_RS03530	COG3595	metallopeptidase activity
B4071_RS03545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4071_RS03550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4071_RS03555	COG0556	nucleotide-excision repair
B4071_RS03560	COG4897	Protein conserved in bacteria
B4071_RS03565	COG3848	Pyruvate phosphate dikinase
B4071_RS03565	COG0574	Belongs to the PEP-utilizing enzyme family
B4071_RS03570	COG1309	transcriptional regulator
B4071_RS03575	COG2814	Major facilitator Superfamily
B4071_RS03580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4071_RS03590	COG3409	Peptidoglycan-binding domain 1 protein
B4071_RS03590	COG0793	Belongs to the peptidase S41A family
B4071_RS03595	COG2177	Part of the ABC transporter FtsEX involved in
B4071_RS03600	COG2884	Cell division ATP-binding protein ftsE
B4071_RS03605	COG2010	Cytochrome c
B4071_RS03610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4071_RS03615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B4071_RS03620	COG0653	protein targeting
B4071_RS03625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B4071_RS03640	COG1516	flagellar protein fliS
B4071_RS03645	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B4071_RS03650	COG1334	flagellar protein FlaG
B4071_RS03655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4071_RS03660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B4071_RS03665	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B4071_RS03675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4071_RS03680	COG4786	Flagellar basal body rod
B4071_RS03680	COG1256	bacterial-type flagellum assembly
B4071_RS03685	COG3418	PFAM FlgN family protein
B4071_RS03690	COG2747	anti-sigma28 factor FlgM
B4071_RS03700	COG1040	competence protein
B4071_RS03710	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4071_RS03715	COG1307	EDD domain protein, DegV family
B4071_RS03720	COG2197	response regulator
B4071_RS03725	COG4585	Histidine kinase
B4071_RS03730	COG1739	Uncharacterized protein family UPF0029
B4071_RS03735	COG1316	TRANSCRIPTIONal
B4071_RS03740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4071_RS03745	COG0438	transferase activity, transferring glycosyl groups
B4071_RS03750	COG1215	transferase activity, transferring glycosyl groups
B4071_RS03755	COG3206	protein involved in exopolysaccharide biosynthesis
B4071_RS03760	COG3307	-O-antigen
B4071_RS03765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4071_RS03770	COG0297	glycogen (starch) synthase activity
B4071_RS03770	COG0438	transferase activity, transferring glycosyl groups
B4071_RS03775	COG2244	polysaccharide biosynthetic process
B4071_RS03785	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4071_RS03785	COG2247	cell wall binding repeat
B4071_RS03790	COG2247	cell wall binding repeat
B4071_RS03790	COG2385	sporulation resulting in formation of a cellular spore
B4071_RS03800	COG1316	TRANSCRIPTIONal
B4071_RS03805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4071_RS03810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4071_RS03815	COG1215	transferase activity, transferring glycosyl groups
B4071_RS03815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4071_RS03820	COG0463	Glycosyl transferase, family 2
B4071_RS03835	COG1134	teichoic acid transport
B4071_RS03840	COG1682	transport, permease protein
B4071_RS03845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4071_RS03850	COG0438	transferase activity, transferring glycosyl groups
B4071_RS03855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B4071_RS03860	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B4071_RS03865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4071_RS03875	COG4193	domain, Protein
B4071_RS03880	COG1482	cell wall glycoprotein biosynthetic process
B4071_RS03890	COG0697	spore germination
B4071_RS03895	COG0814	amino acid
B4071_RS03905	COG2814	Major facilitator Superfamily
B4071_RS03910	COG1316	TRANSCRIPTIONal
B4071_RS03915	COG0561	phosphatase activity
B4071_RS03920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4071_RS03925	COG1404	Belongs to the peptidase S8 family
B4071_RS03930	COG1366	Belongs to the anti-sigma-factor antagonist family
B4071_RS03935	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4071_RS03940	COG1122	ATPase activity
B4071_RS03945	COG4721	ABC-type cobalt transport system, permease component
B4071_RS03955	COG0745	RESPONSE REGULATOR receiver
B4071_RS03960	COG3850	Histidine kinase
B4071_RS03960	COG5002	protein histidine kinase activity
B4071_RS03965	COG3212	peptidase
B4071_RS03970	COG3212	peptidase
B4071_RS03990	COG2239	Acts as a magnesium transporter
B4071_RS03995	COG0789	Transcriptional regulator
B4071_RS04010	COG1846	Transcriptional regulator
B4071_RS04015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4071_RS04020	COG0726	polysaccharide deacetylase
B4071_RS04025	COG1408	metallophosphoesterase
B4071_RS04035	COG0463	Glycosyl transferase, family 2
B4071_RS04040	COG3285	dna ligase
B4071_RS04040	COG1793	dna ligase
B4071_RS04045	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B4071_RS04055	COG0586	Pfam SNARE associated Golgi protein
B4071_RS04060	COG0861	Integral membrane protein TerC family
B4071_RS04065	COG1191	sigma factor activity
B4071_RS04085	COG0501	Belongs to the peptidase M48B family
B4071_RS04090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4071_RS04105	COG3594	Acyltransferase
B4071_RS04110	COG5002	protein histidine kinase activity
B4071_RS04115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4071_RS04125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B4071_RS04130	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B4071_RS04135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4071_RS04140	COG0436	Aminotransferase
B4071_RS04145	COG1850	ribulose-bisphosphate carboxylase activity
B4071_RS04150	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B4071_RS04155	COG0235	Class ii aldolase
B4071_RS04160	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B4071_RS04165	COG3339	Conserved Protein
B4071_RS04180	COG3852	Histidine kinase
B4071_RS04185	COG1846	Transcriptional regulator
B4071_RS04190	COG1360	Flagellar Motor Protein
B4071_RS04195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4071_RS04200	COG0542	response to heat
B4071_RS04205	COG3949	Membrane
B4071_RS04210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B4071_RS04215	COG0720	synthase
B4071_RS04220	COG0602	queuosine metabolic process
B4071_RS04225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B4071_RS04230	COG5577	PFAM Coat F domain
B4071_RS04240	COG1063	alcohol dehydrogenase
B4071_RS04245	COG5577	PFAM Coat F domain
B4071_RS04255	COG0346	lactoylglutathione lyase activity
B4071_RS04260	COG4991	sh3 domain protein
B4071_RS04265	COG4991	sh3 domain protein
B4071_RS04270	COG0596	Alpha beta hydrolase
B4071_RS04275	COG5566	PFAM Mor transcription activator
B4071_RS04285	COG2828	Protein conserved in bacteria
B4071_RS04290	COG0583	DNA-binding transcription factor activity
B4071_RS04295	COG2851	Citrate transporter
B4071_RS04300	COG0667	Aldo Keto reductase
B4071_RS04305	COG1595	DNA-templated transcription, initiation
B4071_RS04310	COG3443	Belongs to the bacterial solute-binding protein 9 family
B4071_RS04325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B4071_RS04330	COG2070	2-Nitropropane dioxygenase
B4071_RS04340	COG2318	DinB family
B4071_RS04350	COG1335	isochorismatase
B4071_RS04365	COG2124	cytochrome p450
B4071_RS04370	COG2732	(Barnase) inhibitor
B4071_RS04375	COG1522	sequence-specific DNA binding
B4071_RS04385	COG1687	branched-chain amino acid
B4071_RS04390	COG1114	Component of the transport system for branched-chain amino acids
B4071_RS04405	COG1942	4-Oxalocrotonate Tautomerase
B4071_RS04410	COG1230	cation diffusion facilitator family transporter
B4071_RS04415	COG2072	flavoprotein involved in K transport
B4071_RS04420	COG0583	DNA-binding transcription factor activity
B4071_RS04425	COG0697	spore germination
B4071_RS04435	COG1253	flavin adenine dinucleotide binding
B4071_RS04440	COG0456	acetyltransferase
B4071_RS04445	COG2814	Major facilitator Superfamily
B4071_RS04450	COG0789	Transcriptional regulator
B4071_RS04450	COG4978	Transcriptional regulator
B4071_RS04465	COG0662	Cupin 2, conserved barrel domain protein
B4071_RS04470	COG1937	Protein conserved in bacteria
B4071_RS04475	COG2210	Belongs to the sulfur carrier protein TusA family
B4071_RS04480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4071_RS04480	COG0425	Belongs to the sulfur carrier protein TusA family
B4071_RS04490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4071_RS04490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4071_RS04495	COG0425	Belongs to the sulfur carrier protein TusA family
B4071_RS04500	COG0730	response to heat
B4071_RS04505	COG4124	Belongs to the glycosyl hydrolase 26 family
B4071_RS04530	COG2267	carboxylic ester hydrolase activity
B4071_RS04540	COG2132	Multicopper oxidase
B4071_RS04545	COG1113	amino acid transport
B4071_RS04555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4071_RS04560	COG0714	Associated with various cellular activities
B4071_RS04565	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B4071_RS04570	COG1305	Transglutaminase-like
B4071_RS04575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B4071_RS04575	COG0519	Catalyzes the synthesis of GMP from XMP
B4071_RS04590	COG2252	PERMEase
B4071_RS04595	COG3064	Membrane
B4071_RS04605	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B4071_RS04615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4071_RS04620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B4071_RS04625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4071_RS04630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B4071_RS04635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4071_RS04640	COG0047	phosphoribosylformylglycinamidine synthase activity
B4071_RS04645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4071_RS04650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B4071_RS04655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B4071_RS04660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4071_RS04665	COG0138	bifunctional purine biosynthesis protein purh
B4071_RS04670	COG0151	Belongs to the GarS family
B4071_RS04675	COG1522	sequence-specific DNA binding
B4071_RS04680	COG0531	amino acid
B4071_RS04690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4071_RS04695	COG1470	cell adhesion involved in biofilm formation
B4071_RS04700	COG4496	protein, YerC YecD
B4071_RS04705	COG0069	glutamate synthase activity
B4071_RS04710	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B4071_RS04715	COG0210	DNA helicase
B4071_RS04720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B4071_RS04725	COG4851	CamS sex pheromone cAM373 precursor
B4071_RS04735	COG1234	tRNA 3'-trailer cleavage
B4071_RS04740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4071_RS04745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4071_RS04750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4071_RS04760	COG0706	membrane insertase activity
B4071_RS04765	COG3361	conserved protein (COG2071)
B4071_RS04780	COG0778	Nitroreductase
B4071_RS04785	COG1733	regulation of RNA biosynthetic process
B4071_RS04790	COG1942	4-Oxalocrotonate Tautomerase
B4071_RS04795	COG2610	gluconate transmembrane transporter activity
B4071_RS04820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4071_RS04825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4071_RS04830	COG1366	Belongs to the anti-sigma-factor antagonist family
B4071_RS04835	COG0534	Mate efflux family protein
B4071_RS04840	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4071_RS04845	COG1819	glycosyl
B4071_RS04850	COG1388	LysM domain
B4071_RS04850	COG0791	NLP P60 protein
B4071_RS04855	COG2032	superoxide dismutase activity
B4071_RS04860	COG0714	Associated with various cellular activities
B4071_RS04865	COG4548	von Willebrand factor, type A
B4071_RS04870	COG0567	Dehydrogenase, E1 component
B4071_RS04875	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4071_RS04880	COG0385	Bile acid
B4071_RS04885	COG0733	neurotransmitter:sodium symporter activity
B4071_RS04890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4071_RS04895	COG1657	PFAM Prenyltransferase squalene oxidase
B4071_RS04900	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS04925	COG0071	Belongs to the small heat shock protein (HSP20) family
B4071_RS04940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4071_RS04945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4071_RS04955	COG0514	ATP-dependent DNA helicase (RecQ)
B4071_RS04960	COG3584	3D domain protein
B4071_RS04960	COG1388	LysM domain
B4071_RS04965	COG2197	response regulator
B4071_RS04970	COG4585	Histidine kinase
B4071_RS04975	COG3239	Fatty acid desaturase
B4071_RS04980	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4071_RS04995	COG2322	membrane
B4071_RS05010	COG1956	GAF domain-containing protein
B4071_RS05015	COG1309	transcriptional regulator
B4071_RS05020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4071_RS05025	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B4071_RS05030	COG1114	Component of the transport system for branched-chain amino acids
B4071_RS05035	COG1104	cysteine desulfurase activity
B4071_RS05040	COG0301	tRNA thio-modification
B4071_RS05050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4071_RS05055	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B4071_RS05060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4071_RS05065	COG0616	signal peptide processing
B4071_RS05070	COG1714	RDD family
B4071_RS05080	COG3874	Sporulation protein YtfJ
B4071_RS05085	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B4071_RS05090	COG0827	DNA restriction-modification system
B4071_RS05095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B4071_RS05100	COG0521	Mo-molybdopterin cofactor biosynthetic process
B4071_RS05105	COG0137	argininosuccinate synthase activity
B4071_RS05110	COG0165	Argininosuccinate lyase
B4071_RS05120	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS05125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B4071_RS05130	COG0583	DNA-binding transcription factor activity
B4071_RS05135	COG0454	-acetyltransferase
B4071_RS05140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4071_RS05145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4071_RS05150	COG0765	amino acid transport
B4071_RS05155	COG0765	amino acid transport
B4071_RS05160	COG1126	abc transporter atp-binding protein
B4071_RS05165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4071_RS05170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B4071_RS05175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4071_RS05180	COG0196	riboflavin kinase activity
B4071_RS05190	COG0730	response to heat
B4071_RS05200	COG4109	DRTGG domain
B4071_RS05210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4071_RS05230	COG0587	DNA-directed DNA polymerase activity
B4071_RS05235	COG0281	malic enzyme
B4071_RS05240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B4071_RS05245	COG0825	malonyl-CoA metabolic process
B4071_RS05250	COG0205	6-phosphofructokinase activity
B4071_RS05255	COG0469	pyruvate kinase activity
B4071_RS05260	COG3030	protein affecting phage T7 exclusion by the F plasmid
B4071_RS05265	COG0628	permease
B4071_RS05270	COG2707	UPF0756 membrane protein
B4071_RS05275	COG0372	Belongs to the citrate synthase family
B4071_RS05280	COG0538	isocitrate dehydrogenase activity
B4071_RS05285	COG0039	L-malate dehydrogenase activity
B4071_RS05290	COG0745	RESPONSE REGULATOR receiver
B4071_RS05295	COG5002	protein histidine kinase activity
B4071_RS05300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4071_RS05300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4071_RS05305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4071_RS05320	COG0237	dephospho-CoA kinase activity
B4071_RS05345	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4071_RS05350	COG0398	Pfam SNARE associated Golgi protein
B4071_RS05355	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4071_RS05355	COG3409	Peptidoglycan-binding domain 1 protein
B4071_RS05360	COG2755	lipolytic protein G-D-S-L family
B4071_RS05375	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4071_RS05380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4071_RS05385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4071_RS05390	COG1534	Rna-binding protein
B4071_RS05395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B4071_RS05400	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4071_RS05405	COG0799	negative regulation of ribosome biogenesis
B4071_RS05410	COG2226	methyltransferase
B4071_RS05415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4071_RS05420	COG1555	photosystem II stabilization
B4071_RS05420	COG1596	polysaccharide export
B4071_RS05425	COG2131	deaminase
B4071_RS05430	COG2333	competence protein COMEC
B4071_RS05430	COG0658	competence protein
B4071_RS05440	COG1466	dna polymerase III delta subunit
B4071_RS05445	COG0268	Binds directly to 16S ribosomal RNA
B4071_RS05450	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B4071_RS05455	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4071_RS05465	COG0481	GTPase activity
B4071_RS05470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4071_RS05475	COG1420	regulation of RNA biosynthetic process
B4071_RS05480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B4071_RS05485	COG0443	Heat shock 70 kDa protein
B4071_RS05490	COG0484	heat shock protein binding
B4071_RS05495	COG2264	protein methyltransferase activity
B4071_RS05500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4071_RS05505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4071_RS05510	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4071_RS05520	COG1610	YqeY-like protein
B4071_RS05525	COG1030	water channel activity
B4071_RS05530	COG4864	UPF0365 protein
B4071_RS05545	COG0561	phosphatase activity
B4071_RS05550	COG1702	phosphate starvation-inducible protein PhoH
B4071_RS05560	COG1480	7TM receptor with intracellular HD hydrolase
B4071_RS05565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B4071_RS05570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4071_RS05575	COG0295	cytidine deaminase activity
B4071_RS05580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B4071_RS05590	COG1381	Involved in DNA repair and RecF pathway recombination
B4071_RS05595	COG0752	glycyl-tRNA synthetase alpha subunit
B4071_RS05600	COG0751	glycine-tRNA ligase activity
B4071_RS05605	COG0517	IMP dehydrogenase activity
B4071_RS05610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B4071_RS05615	COG1671	Belongs to the UPF0178 family
B4071_RS05620	COG0358	DNA primase activity
B4071_RS05625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4071_RS05630	COG2010	Cytochrome c
B4071_RS05635	COG2384	SAM-dependent methyltransferase
B4071_RS05640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B4071_RS05650	COG2124	cytochrome p450
B4071_RS05650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4071_RS05655	COG1368	sulfuric ester hydrolase activity
B4071_RS05660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4071_RS05665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4071_RS05670	COG1442	glycosyl transferase family 8
B4071_RS05675	COG1216	Glycosyl transferase, family 2
B4071_RS05680	COG1442	glycosyl transferase family 8
B4071_RS05685	COG2223	nitrite transmembrane transporter activity
B4071_RS05695	COG0531	amino acid
B4071_RS05700	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS05705	COG0840	transmembrane signaling receptor activity
B4071_RS05710	COG0488	(ABC) transporter
B4071_RS05720	COG0789	Transcriptional regulator
B4071_RS05725	COG2814	Major facilitator Superfamily
B4071_RS05745	COG0590	tRNA wobble adenosine to inosine editing
B4071_RS05750	COG1764	response to oxidative stress
B4071_RS05755	COG1846	Transcriptional regulator
B4071_RS05760	COG1764	response to oxidative stress
B4071_RS05765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B4071_RS05770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4071_RS05775	COG0788	formyltetrahydrofolate deformylase activity
B4071_RS05780	COG2076	Multidrug Resistance protein
B4071_RS05785	COG2076	Multidrug Resistance protein
B4071_RS05790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4071_RS05795	COG2318	DinB family
B4071_RS05800	COG2323	membrane
B4071_RS05810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B4071_RS05810	COG1017	nitric oxide dioxygenase activity
B4071_RS05815	COG1607	acyl-coa hydrolase
B4071_RS05820	COG1834	amidinotransferase
B4071_RS05825	COG2706	6-phosphogluconolactonase activity
B4071_RS05830	COG4608	Belongs to the ABC transporter superfamily
B4071_RS05835	COG0791	NLP P60 protein
B4071_RS05840	COG4948	Mandelate Racemase Muconate Lactonizing
B4071_RS05845	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4071_RS05850	COG4166	transmembrane transport
B4071_RS05855	COG0444	Belongs to the ABC transporter superfamily
B4071_RS05860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4071_RS05865	COG0601	transmembrane transport
B4071_RS05870	COG2362	D-Aminopeptidase
B4071_RS05875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4071_RS05880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4071_RS05890	COG0463	Glycosyl transferase, family 2
B4071_RS05895	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B4071_RS05900	COG0346	lactoylglutathione lyase activity
B4071_RS05905	COG0531	amino acid
B4071_RS05910	COG1392	Phosphate transport regulator
B4071_RS05915	COG0306	phosphate transporter
B4071_RS05930	COG3409	Peptidoglycan-binding domain 1 protein
B4071_RS05930	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4071_RS05965	COG3778	Protein conserved in bacteria
B4071_RS05970	COG3299	homolog of phage Mu protein gp47
B4071_RS05975	COG3628	GPW Gp25 family protein
B4071_RS05985	COG4193	domain, Protein
B4071_RS05990	COG1652	LysM domain
B4071_RS05995	COG3953	SLT domain
B4071_RS05995	COG5412	phage tail tape measure protein
B4071_RS06045	COG4653	Phage capsid family
B4071_RS06050	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B4071_RS06055	COG5518	Phage portal protein
B4071_RS06060	COG1783	phage Terminase large subunit
B4071_RS06065	COG3728	DNA packaging
B4071_RS06065	COG5484	DNA packaging
B4071_RS06070	COG1595	DNA-templated transcription, initiation
B4071_RS06100	COG1522	sequence-specific DNA binding
B4071_RS06110	COG1396	sequence-specific DNA binding
B4071_RS06115	COG2856	Zn peptidase
B4071_RS06120	COG3546	catalase activity
B4071_RS06125	COG4195	phage-related replication protein
B4071_RS06135	COG1388	LysM domain
B4071_RS06135	COG3409	Peptidoglycan-binding domain 1 protein
B4071_RS06135	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4071_RS06140	COG2350	Protein conserved in bacteria
B4071_RS06150	COG0457	Tetratricopeptide repeat
B4071_RS06155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4071_RS06160	COG2318	DinB family
B4071_RS06165	COG0730	response to heat
B4071_RS06170	COG2721	sulfolactate sulfo-lyase activity
B4071_RS06175	COG0246	Mannitol dehydrogenase
B4071_RS06180	COG1609	Transcriptional regulator
B4071_RS06185	COG2271	Major facilitator Superfamily
B4071_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS06195	COG1312	Catalyzes the dehydration of D-mannonate
B4071_RS06200	COG1063	alcohol dehydrogenase
B4071_RS06205	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B4071_RS06210	COG2211	Major facilitator Superfamily
B4071_RS06215	COG1904	glucuronate isomerase
B4071_RS06220	COG1252	NADH dehydrogenase
B4071_RS06230	COG4297	protein containing double-stranded beta helix domain
B4071_RS06235	COG0697	spore germination
B4071_RS06240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4071_RS06245	COG0390	transport system, permease component
B4071_RS06250	COG1587	Uroporphyrinogen-III synthase
B4071_RS06260	COG1819	glycosyl
B4071_RS06265	COG2124	cytochrome p450
B4071_RS06285	COG2427	Protein of unknown function (DUF1641)
B4071_RS06300	COG2205	protein histidine kinase activity
B4071_RS06305	COG5504	Zn-dependent protease
B4071_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS06330	COG1309	transcriptional regulator
B4071_RS06335	COG1917	Cupin 2, conserved barrel domain protein
B4071_RS06340	COG2311	Membrane
B4071_RS06345	COG1714	RDD family
B4071_RS06355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4071_RS06365	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS06370	COG1309	transcriptional regulator
B4071_RS06375	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS06385	COG0326	Molecular chaperone. Has ATPase activity
B4071_RS06390	COG2814	Major facilitator Superfamily
B4071_RS06405	COG0667	Aldo Keto reductase
B4071_RS06410	COG1349	DNA-binding transcription factor activity
B4071_RS06415	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS06420	COG3718	enzyme involved in inositol metabolism
B4071_RS06425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4071_RS06430	COG3962	Belongs to the TPP enzyme family
B4071_RS06435	COG1082	Xylose isomerase domain protein TIM barrel
B4071_RS06440	COG2814	Major facilitator Superfamily
B4071_RS06445	COG0673	inositol 2-dehydrogenase activity
B4071_RS06450	COG1082	Xylose isomerase domain protein TIM barrel
B4071_RS06455	COG1082	Xylose isomerase domain protein TIM barrel
B4071_RS06460	COG0191	fructose-bisphosphate aldolase activity
B4071_RS06465	COG0745	RESPONSE REGULATOR receiver
B4071_RS06470	COG2205	protein histidine kinase activity
B4071_RS06475	COG1136	(ABC) transporter
B4071_RS06480	COG0577	efflux transmembrane transporter activity
B4071_RS06485	COG5294	Protein conserved in bacteria
B4071_RS06490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4071_RS06520	COG0561	phosphatase activity
B4071_RS06525	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B4071_RS06530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4071_RS06535	COG0456	acetyltransferase
B4071_RS06540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4071_RS06545	COG0765	amino acid transport
B4071_RS06550	COG1126	abc transporter atp-binding protein
B4071_RS06555	COG1473	amidohydrolase
B4071_RS06560	COG2079	MmgE PrpD family protein
B4071_RS06565	COG3192	ethanolamine utilization protein
B4071_RS06575	COG2390	Transcriptional regulator
B4071_RS06580	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B4071_RS06585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4071_RS06590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B4071_RS06595	COG0833	amino acid
B4071_RS06600	COG0010	Belongs to the arginase family
B4071_RS06605	COG1228	amidohydrolase
B4071_RS06610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B4071_RS06615	COG2986	histidine ammonia-lyase
B4071_RS06625	COG3507	Belongs to the glycosyl hydrolase 43 family
B4071_RS06660	COG5444	nuclease activity
B4071_RS06680	COG0589	response to stress
B4071_RS06685	COG0697	spore germination
B4071_RS06785	COG2755	lipolytic protein G-D-S-L family
B4071_RS06785	COG3401	FG-GAP repeat protein
B4071_RS06790	COG0513	Belongs to the DEAD box helicase family
B4071_RS06795	COG2270	Major facilitator Superfamily
B4071_RS06810	COG2273	Hydrolase Family 16
B4071_RS06815	COG2851	Citrate transporter
B4071_RS06820	COG0753	catalase activity
B4071_RS06820	COG0693	protein deglycase activity
B4071_RS06835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4071_RS06840	COG2340	Cysteine-rich secretory protein family
B4071_RS06845	COG0768	penicillin binding
B4071_RS06850	COG4191	Histidine kinase
B4071_RS06855	COG0436	Aminotransferase
B4071_RS06865	COG0784	Response regulator, receiver
B4071_RS06865	COG0835	chemotaxis
B4071_RS06875	COG2814	Major facilitator Superfamily
B4071_RS06880	COG1376	ErfK ybiS ycfS ynhG family protein
B4071_RS06885	COG1408	metallophosphoesterase
B4071_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS06895	COG3409	Peptidoglycan-binding domain 1 protein
B4071_RS06905	COG2200	EAL domain
B4071_RS06915	COG4703	Protein of unknown function (DUF1797)
B4071_RS06920	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B4071_RS06930	COG0517	IMP dehydrogenase activity
B4071_RS06935	COG0583	DNA-binding transcription factor activity
B4071_RS06940	COG0716	FMN binding
B4071_RS06950	COG0716	FMN binding
B4071_RS06955	COG2171	N-acyltransferase activity
B4071_RS06960	COG1473	amidohydrolase
B4071_RS06970	COG0668	transmembrane transport
B4071_RS06975	COG0450	alkyl hydroperoxide reductase
B4071_RS06980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS07010	COG5039	Polysaccharide pyruvyl transferase
B4071_RS07015	COG1929	Belongs to the glycerate kinase type-1 family
B4071_RS07020	COG1802	Transcriptional regulator
B4071_RS07025	COG1070	Carbohydrate kinase
B4071_RS07030	COG2610	gluconate transmembrane transporter activity
B4071_RS07035	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4071_RS07040	COG0450	alkyl hydroperoxide reductase
B4071_RS07045	COG3634	alkyl hydroperoxide reductase activity
B4071_RS07050	COG2723	6-phospho-beta-galactosidase activity
B4071_RS07055	COG2190	(PTS) system
B4071_RS07060	COG2188	Transcriptional regulator
B4071_RS07070	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
B4071_RS07080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4071_RS07085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4071_RS07090	COG1396	sequence-specific DNA binding
B4071_RS07095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4071_RS07100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4071_RS07105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4071_RS07110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4071_RS07115	COG0512	Glutamine amidotransferase of anthranilate synthase
B4071_RS07120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4071_RS07125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4071_RS07130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4071_RS07135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B4071_RS07140	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B4071_RS07145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4071_RS07150	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B4071_RS07155	COG0037	tRNA processing
B4071_RS07160	COG0515	serine threonine protein kinase
B4071_RS07165	COG2304	oxidoreductase activity
B4071_RS07170	COG2208	phosphoserine phosphatase activity
B4071_RS07185	COG1098	S1 RNA binding domain
B4071_RS07190	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B4071_RS07205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4071_RS07210	COG3956	TIGRFAM MazG family protein
B4071_RS07215	COG2244	polysaccharide biosynthetic process
B4071_RS07220	COG2002	toxin-antitoxin pair type II binding
B4071_RS07225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4071_RS07235	COG0193	aminoacyl-tRNA hydrolase activity
B4071_RS07240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B4071_RS07245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4071_RS07250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B4071_RS07260	COG2088	sporulation resulting in formation of a cellular spore
B4071_RS07265	COG0251	oxidation-reduction process
B4071_RS07270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4071_RS07275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B4071_RS07285	COG4466	Protein conserved in bacteria
B4071_RS07295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B4071_RS07300	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4071_RS07305	COG3584	3D domain protein
B4071_RS07305	COG3583	domain protein
B4071_RS07310	COG0084	hydrolase, TatD family'
B4071_RS07315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4071_RS07315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4071_RS07320	COG2002	toxin-antitoxin pair type II binding
B4071_RS07325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4071_RS07330	COG2827	Endonuclease containing a URI domain
B4071_RS07335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4071_RS07340	COG4467	Involved in initiation control of chromosome replication
B4071_RS07345	COG1774	PSP1 C-terminal conserved region
B4071_RS07350	COG0470	DNA polymerase III
B4071_RS07355	COG1728	Protein conserved in bacteria
B4071_RS07360	COG3870	Protein conserved in bacteria
B4071_RS07365	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4071_RS07370	COG1982	Orn Lys Arg decarboxylase major
B4071_RS07375	COG3853	Toxic anion resistance protein (TelA)
B4071_RS07380	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
B4071_RS07530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4071_RS07545	COG1073	alpha beta
B4071_RS07550	COG2205	protein histidine kinase activity
B4071_RS07560	COG0457	Tetratricopeptide repeat
B4071_RS07570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4071_RS07605	COG1192	Involved in chromosome partitioning
B4071_RS07755	COG2084	Dehydrogenase
B4071_RS07760	COG0840	transmembrane signaling receptor activity
B4071_RS07765	COG0456	acetyltransferase
B4071_RS07770	COG1533	DNA photolyase activity
B4071_RS07780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4071_RS07785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4071_RS07790	COG2190	(PTS) system
B4071_RS07790	COG1263	PTS System
B4071_RS07790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4071_RS07795	COG3711	transcriptional antiterminator
B4071_RS07800	COG1609	Transcriptional regulator
B4071_RS07810	COG0006	proline dipeptidase activity
B4071_RS07820	COG2217	Heavy metal translocating P-type atpase
B4071_RS07825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS07830	COG2244	polysaccharide biosynthetic process
B4071_RS07835	COG3773	Cell wall hydrolase
B4071_RS07850	COG4873	Protein conserved in bacteria
B4071_RS07860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B4071_RS07865	COG0582	viral genome integration into host DNA
B4071_RS07890	COG0500	methyltransferase
B4071_RS07900	COG2610	gluconate transmembrane transporter activity
B4071_RS07905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4071_RS07910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4071_RS07920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4071_RS07925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4071_RS07930	COG4894	glucomannan catabolic process
B4071_RS07945	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4071_RS07950	COG2197	response regulator
B4071_RS07955	COG4585	Histidine kinase
B4071_RS07965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4071_RS07975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4071_RS07980	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS07985	COG2508	Transcriptional regulator
B4071_RS07990	COG3842	ATPase activity
B4071_RS07995	COG0726	polysaccharide deacetylase
B4071_RS08005	COG0501	Belongs to the peptidase M48B family
B4071_RS08010	COG3493	citrate carrier protein
B4071_RS08015	COG1271	oxidase subunit
B4071_RS08020	COG1294	oxidase, subunit
B4071_RS08025	COG4988	ABC transporter
B4071_RS08030	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4071_RS08040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4071_RS08045	COG1595	DNA-templated transcription, initiation
B4071_RS08065	COG1131	(ABC) transporter
B4071_RS08070	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4071_RS08080	COG0753	catalase activity
B4071_RS08085	COG2094	Belongs to the DNA glycosylase MPG family
B4071_RS08095	COG3711	transcriptional antiterminator
B4071_RS08095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4071_RS08100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4071_RS08110	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4071_RS08115	COG1486	melibiose metabolic process
B4071_RS08120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4071_RS08125	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B4071_RS08130	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B4071_RS08135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4071_RS08140	COG1696	Membrane protein involved in D-alanine export
B4071_RS08145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4071_RS08160	COG1575	Belongs to the MenA family. Type 1 subfamily
B4071_RS08165	COG2357	RelA SpoT domain protein
B4071_RS08170	COG2814	Major facilitator Superfamily
B4071_RS08185	COG2234	aminopeptidase activity
B4071_RS08190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4071_RS08195	COG1846	Transcriptional regulator
B4071_RS08205	COG1442	glycosyl transferase family 8
B4071_RS08210	COG3711	transcriptional antiterminator
B4071_RS08215	COG1263	PTS System
B4071_RS08215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4071_RS08220	COG1404	Belongs to the peptidase S8 family
B4071_RS08225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4071_RS08235	COG0346	lactoylglutathione lyase activity
B4071_RS08240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4071_RS08245	COG4895	conserved protein (DUF2196)
B4071_RS08250	COG2814	Major facilitator Superfamily
B4071_RS08255	COG1346	cytolysis
B4071_RS08260	COG1380	Effector of murein hydrolase LrgA
B4071_RS08265	COG0583	DNA-binding transcription factor activity
B4071_RS08270	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B4071_RS08275	COG0352	thiamine-phosphate diphosphorylase activity
B4071_RS08280	COG0672	)-iron permease
B4071_RS08285	COG2822	iron ion transport
B4071_RS08290	COG2837	iron assimilation
B4071_RS08295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4071_RS08300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4071_RS08305	COG3162	membrane
B4071_RS08315	COG1309	transcriptional regulator
B4071_RS08320	COG2246	polysaccharide biosynthetic process
B4071_RS08325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B4071_RS08330	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B4071_RS08335	COG2261	transglycosylase associated protein
B4071_RS08340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4071_RS08345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4071_RS08350	COG1845	cytochrome c oxidase, subunit III
B4071_RS08355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B4071_RS08365	COG0772	Belongs to the SEDS family
B4071_RS08370	COG0778	Nitroreductase
B4071_RS08375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4071_RS08380	COG1404	Belongs to the peptidase S8 family
B4071_RS08390	COG3711	transcriptional antiterminator
B4071_RS08395	COG2116	formate transmembrane transporter activity
B4071_RS08400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4071_RS08400	COG1263	PTS System
B4071_RS08405	COG1621	beta-fructofuranosidase activity
B4071_RS08415	COG0351	phosphomethylpyrimidine kinase
B4071_RS08420	COG1695	Transcriptional regulator
B4071_RS08435	COG1216	Glycosyl transferase, family 2
B4071_RS08440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4071_RS08445	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS08455	COG2233	PERMEase
B4071_RS08460	COG2363	Small membrane protein
B4071_RS08475	COG0463	Glycosyl transferase, family 2
B4071_RS08480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4071_RS08485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4071_RS08490	COG0456	acetyltransferase
B4071_RS08495	COG2089	acid synthase
B4071_RS08500	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
B4071_RS08505	COG3980	spore coat polysaccharide biosynthesis protein
B4071_RS08510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B4071_RS08515	COG1088	dTDP-glucose 4,6-dehydratase activity
B4071_RS08520	COG1091	dTDP-4-dehydrorhamnose reductase activity
B4071_RS08525	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B4071_RS08540	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS08545	COG4187	Peptidase family M20/M25/M40
B4071_RS08550	COG0833	amino acid
B4071_RS08555	COG2814	Major facilitator Superfamily
B4071_RS08560	COG0077	Prephenate dehydratase
B4071_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS08580	COG0436	Aminotransferase
B4071_RS08585	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS08590	COG3253	May function as heme-dependent peroxidase
B4071_RS08595	COG0280	phosphate acetyltransferase
B4071_RS08600	COG0583	DNA-binding transcription factor activity
B4071_RS08605	COG0095	Lipoate-protein ligase
B4071_RS08610	COG0697	spore germination
B4071_RS08620	COG4844	belongs to the
B4071_RS08625	COG1078	dGTPase activity
B4071_RS08630	COG3465	dGTPase activity
B4071_RS08635	COG1959	2 iron, 2 sulfur cluster binding
B4071_RS08640	COG0477	Major facilitator Superfamily
B4071_RS08650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4071_RS08655	COG1846	Transcriptional regulator
B4071_RS08660	COG1942	4-Oxalocrotonate Tautomerase
B4071_RS08665	COG1994	Peptidase M50
B4071_RS08675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4071_RS08680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B4071_RS08685	COG0010	Belongs to the arginase family
B4071_RS08700	COG0457	Tetratricopeptide repeat
B4071_RS08725	COG0612	Peptidase, M16
B4071_RS08730	COG0612	Peptidase, M16
B4071_RS08735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4071_RS08740	COG1131	(ABC) transporter
B4071_RS08750	COG0535	radical SAM domain protein
B4071_RS08760	COG4506	Protein conserved in bacteria
B4071_RS08765	COG0018	arginyl-trna synthetase
B4071_RS08770	COG2223	nitrite transmembrane transporter activity
B4071_RS08775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4071_RS08785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4071_RS08790	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B4071_RS08795	COG1140	nitrate reductase beta subunit
B4071_RS08800	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B4071_RS08805	COG2181	nitrate reductase activity
B4071_RS08815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4071_RS08820	COG1132	(ABC) transporter
B4071_RS08825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4071_RS08835	COG4294	response to UV
B4071_RS08840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4071_RS08845	COG2181	nitrate reductase activity
B4071_RS08845	COG0247	lactate metabolic process
B4071_RS08850	COG1960	acyl-CoA dehydrogenase activity
B4071_RS08855	COG3343	RNA polymerase activity
B4071_RS08860	COG0504	CTP synthase activity
B4071_RS08875	COG4821	SIS domain
B4071_RS08880	COG2204	response regulator
B4071_RS08885	COG0191	fructose-bisphosphate aldolase activity
B4071_RS08890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4071_RS08895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4071_RS08900	COG1494	fructose-1,6-bisphosphatase
B4071_RS08910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4071_RS08920	COG1435	thymidine kinase activity
B4071_RS08925	COG0281	malic enzyme
B4071_RS08930	COG0679	Auxin Efflux Carrier
B4071_RS08935	COG0789	Transcriptional regulator
B4071_RS08940	COG0346	lactoylglutathione lyase activity
B4071_RS08945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B4071_RS08950	COG2890	protein-(glutamine-N5) methyltransferase activity
B4071_RS08970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B4071_RS08975	COG0009	L-threonylcarbamoyladenylate synthase
B4071_RS08980	COG1971	Probably functions as a manganese efflux pump
B4071_RS08985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4071_RS08990	COG0698	ribose 5-phosphate isomerase
B4071_RS08995	COG4475	Protein of unknown function (DUF436)
B4071_RS09000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B4071_RS09005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B4071_RS09015	COG0356	it plays a direct role in the translocation of protons across the membrane
B4071_RS09030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B4071_RS09035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4071_RS09040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B4071_RS09045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B4071_RS09050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4071_RS09055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B4071_RS09065	COG4836	Membrane
B4071_RS09075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4071_RS09080	COG2385	sporulation resulting in formation of a cellular spore
B4071_RS09085	COG2304	oxidoreductase activity
B4071_RS09095	COG2304	oxidoreductase activity
B4071_RS09105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B4071_RS09110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B4071_RS09115	COG0457	Tetratricopeptide repeat
B4071_RS09120	COG1994	Peptidase M50
B4071_RS09125	COG3237	CsbD-like
B4071_RS09155	COG0831	urea catabolic process
B4071_RS09160	COG0832	Belongs to the urease beta subunit family
B4071_RS09165	COG0804	urea catabolic process
B4071_RS09170	COG1959	2 iron, 2 sulfur cluster binding
B4071_RS09175	COG2910	NAD(P)H-binding
B4071_RS09185	COG0789	Transcriptional regulator
B4071_RS09190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4071_RS09210	COG1247	-acetyltransferase
B4071_RS09215	COG0739	heme binding
B4071_RS09225	COG0671	phosphoesterase, PA-phosphatase related
B4071_RS09230	COG0347	Belongs to the P(II) protein family
B4071_RS09235	COG0004	ammonium transporteR
B4071_RS09245	COG1335	isochorismatase
B4071_RS09250	COG0477	Major facilitator Superfamily
B4071_RS09255	COG1953	Uracil, thiamine, allantoin
B4071_RS09260	COG3420	alginic acid biosynthetic process
B4071_RS09265	COG2814	Major facilitator Superfamily
B4071_RS09270	COG1846	Transcriptional regulator
B4071_RS09275	COG1609	Transcriptional regulator
B4071_RS09280	COG1077	Cell shape determining protein MreB Mrl
B4071_RS09285	COG4786	Flagellar basal body rod
B4071_RS09290	COG4786	Flagellar basal body rod
B4071_RS09295	COG0457	Tetratricopeptide repeat
B4071_RS09300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4071_RS09305	COG1970	mechanosensitive ion channel activity
B4071_RS09310	COG2972	Histidine kinase
B4071_RS09310	COG0745	RESPONSE REGULATOR receiver
B4071_RS09315	COG3764	Sortase (surface protein transpeptidase)
B4071_RS09330	COG0629	single-stranded DNA binding
B4071_RS09335	COG1349	DNA-binding transcription factor activity
B4071_RS09340	COG0561	phosphatase activity
B4071_RS09345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4071_RS09350	COG4715	Zinc finger, swim domain protein
B4071_RS09360	COG3944	biosynthesis protein
B4071_RS09365	COG0489	protein tyrosine kinase activity
B4071_RS09370	COG4464	protein tyrosine phosphatase activity
B4071_RS09375	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4071_RS09380	COG3878	Protein conserved in bacteria
B4071_RS09395	COG5444	nuclease activity
B4071_RS09410	COG5444	nuclease activity
B4071_RS09425	COG0583	DNA-binding transcription factor activity
B4071_RS09430	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4071_RS09440	COG2059	Chromate
B4071_RS09445	COG2059	Chromate
B4071_RS09450	COG1522	sequence-specific DNA binding
B4071_RS09455	COG0405	Gamma-glutamyltransferase
B4071_RS09465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4071_RS09475	COG5337	Spore coat protein CotH
B4071_RS09495	COG0583	DNA-binding transcription factor activity
B4071_RS09500	COG0028	Belongs to the TPP enzyme family
B4071_RS09505	COG3527	Alpha-acetolactate decarboxylase
B4071_RS09510	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4071_RS09520	COG3103	Sh3 type 3 domain protein
B4071_RS09525	COG1879	ABC-type sugar transport system periplasmic component
B4071_RS09530	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4071_RS09535	COG1129	ABC transporter
B4071_RS09540	COG1869	D-ribose catabolic process
B4071_RS09545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4071_RS09550	COG1609	Transcriptional regulator
B4071_RS09555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4071_RS09565	COG2843	Capsule synthesis protein
B4071_RS09575	COG0791	NLP P60 protein
B4071_RS09580	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4071_RS09585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4071_RS09590	COG0346	lactoylglutathione lyase activity
B4071_RS09600	COG1376	ErfK ybiS ycfS ynhG family protein
B4071_RS09605	COG4129	membrane
B4071_RS09610	COG1126	abc transporter atp-binding protein
B4071_RS09615	COG0765	amino acid transport
B4071_RS09620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4071_RS09630	COG1597	lipid kinase activity
B4071_RS09635	COG2814	Major facilitator Superfamily
B4071_RS09640	COG4978	Transcriptional regulator
B4071_RS09640	COG0789	Transcriptional regulator
B4071_RS09645	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4071_RS09650	COG0022	dehydrogenase e1 component
B4071_RS09655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4071_RS09660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4071_RS09665	COG3426	butyrate kinase activity
B4071_RS09670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4071_RS09675	COG0280	phosphate acetyltransferase
B4071_RS09680	COG3290	protein histidine kinase activity
B4071_RS09680	COG3829	transcription factor binding
B4071_RS09690	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B4071_RS09695	COG2079	MmgE PrpD family protein
B4071_RS09700	COG0372	Belongs to the citrate synthase family
B4071_RS09705	COG1960	acyl-CoA dehydrogenase activity
B4071_RS09710	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4071_RS09715	COG0183	Belongs to the thiolase family
B4071_RS09720	COG0584	glycerophosphoryl diester phosphodiesterase
B4071_RS09725	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4071_RS09740	COG1902	pentaerythritol trinitrate reductase activity
B4071_RS09750	COG0745	RESPONSE REGULATOR receiver
B4071_RS09760	COG0750	zinc metalloprotease
B4071_RS09765	COG0497	DNA recombination
B4071_RS09770	COG1438	arginine binding
B4071_RS09775	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B4071_RS09780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B4071_RS09785	COG0142	geranyltranstransferase activity
B4071_RS09790	COG1722	exodeoxyribonuclease VII activity
B4071_RS09795	COG1570	exodeoxyribonuclease VII activity
B4071_RS09800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B4071_RS09805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4071_RS09810	COG1302	Protein conserved in bacteria
B4071_RS09815	COG0439	Biotin carboxylase
B4071_RS09820	COG0511	ligase activity, forming carbon-carbon bonds
B4071_RS09860	COG3854	ATPases associated with a variety of cellular activities
B4071_RS09870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B4071_RS09875	COG0006	proline dipeptidase activity
B4071_RS09880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B4071_RS09890	COG3872	metal-dependent enzyme
B4071_RS09900	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4071_RS09905	COG1321	iron dependent repressor
B4071_RS09910	COG0095	Lipoate-protein ligase
B4071_RS09915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4071_RS09920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4071_RS09925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4071_RS09930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B4071_RS09935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4071_RS09950	COG1396	sequence-specific DNA binding
B4071_RS09960	COG0681	Belongs to the peptidase S26 family
B4071_RS09985	COG4940	Competence protein ComGF
B4071_RS09995	COG4970	Tfp pilus assembly protein FimT
B4071_RS10000	COG4537	Required for transformation and DNA binding
B4071_RS10005	COG1459	type II secretion system
B4071_RS10010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4071_RS10015	COG0598	Magnesium transport protein CorA
B4071_RS10020	COG1253	flavin adenine dinucleotide binding
B4071_RS10025	COG1366	Belongs to the anti-sigma-factor antagonist family
B4071_RS10035	COG1393	Belongs to the ArsC family
B4071_RS10045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4071_RS10055	COG0011	TIGRFAM Protein of
B4071_RS10065	COG2866	Carboxypeptidase
B4071_RS10070	COG1368	sulfuric ester hydrolase activity
B4071_RS10075	COG1940	carbohydrate kinase activity
B4071_RS10080	COG4483	Protein conserved in bacteria
B4071_RS10085	COG0457	Tetratricopeptide repeat
B4071_RS10085	COG0705	Rhomboid family
B4071_RS10095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4071_RS10105	COG0438	transferase activity, transferring glycosyl groups
B4071_RS10120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4071_RS10125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4071_RS10130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4071_RS10135	COG0581	inorganic phosphate transmembrane transporter activity
B4071_RS10140	COG0573	inorganic phosphate transmembrane transporter activity
B4071_RS10145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4071_RS10150	COG0768	penicillin binding
B4071_RS10155	COG0477	Major facilitator Superfamily
B4071_RS10160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4071_RS10165	COG2839	Protein conserved in bacteria
B4071_RS10170	COG5521	maltodextrose utilization protein MalA
B4071_RS10175	COG1388	LysM domain
B4071_RS10180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B4071_RS10185	COG4709	membrane
B4071_RS10190	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B4071_RS10195	COG0735	belongs to the Fur family
B4071_RS10200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4071_RS10210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B4071_RS10215	COG0513	Belongs to the DEAD box helicase family
B4071_RS10225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B4071_RS10245	COG1793	dna ligase
B4071_RS10275	COG0629	single-stranded DNA binding
B4071_RS10290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4071_RS10290	COG0551	DNA topoisomerase type I activity
B4071_RS10360	COG3883	PFAM NLP P60 protein
B4071_RS10360	COG0791	NLP P60 protein
B4071_RS10395	COG0659	secondary active sulfate transmembrane transporter activity
B4071_RS10400	COG0385	Bile acid
B4071_RS10405	COG2819	hydrolase of the alpha beta superfamily
B4071_RS10410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS10415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS10420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4071_RS10425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4071_RS10425	COG2207	Transcriptional regulator
B4071_RS10430	COG3876	Protein conserved in bacteria
B4071_RS10435	COG1472	Belongs to the glycosyl hydrolase 3 family
B4071_RS10440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4071_RS10445	COG1263	PTS System
B4071_RS10445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4071_RS10450	COG1737	Transcriptional regulator
B4071_RS10455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B4071_RS10460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4071_RS10465	COG1683	Conserved Protein
B4071_RS10485	COG1595	DNA-templated transcription, initiation
B4071_RS10490	COG5662	AntiSigma factor
B4071_RS10495	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4071_RS10500	COG4856	YbbR-like protein
B4071_RS10505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4071_RS10510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4071_RS10515	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4071_RS10520	COG2169	Transcriptional regulator
B4071_RS10525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4071_RS10530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4071_RS10535	COG3002	Belongs to the UPF0753 family
B4071_RS10540	COG0288	reversible hydration of carbon dioxide
B4071_RS10550	COG5609	conserved protein (DUF2294)
B4071_RS10555	COG0640	Transcriptional regulator
B4071_RS10560	COG2814	Major facilitator Superfamily
B4071_RS10575	COG0535	radical SAM domain protein
B4071_RS10580	COG1266	CAAX protease self-immunity
B4071_RS10585	COG1131	(ABC) transporter
B4071_RS10595	COG1413	lyase activity
B4071_RS10600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS10605	COG0596	Alpha beta hydrolase
B4071_RS10610	COG0745	RESPONSE REGULATOR receiver
B4071_RS10615	COG0642	Histidine kinase
B4071_RS10625	COG0515	serine threonine protein kinase
B4071_RS10640	COG1113	amino acid transport
B4071_RS10655	COG2602	Beta-lactamase
B4071_RS10670	COG0531	amino acid
B4071_RS10675	COG0584	glycerophosphoryl diester phosphodiesterase
B4071_RS10680	COG2271	Major facilitator Superfamily
B4071_RS10690	COG1846	Transcriptional regulator
B4071_RS10690	COG0456	acetyltransferase
B4071_RS10695	COG2271	Major facilitator Superfamily
B4071_RS10705	COG3409	Peptidoglycan-binding domain 1 protein
B4071_RS10715	COG2207	Transcriptional regulator
B4071_RS10715	COG1917	Cupin 2, conserved barrel domain protein
B4071_RS10720	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B4071_RS10725	COG3591	Belongs to the peptidase S1B family
B4071_RS10735	COG0596	Alpha beta hydrolase
B4071_RS10740	COG1183	phosphatidylcholine synthase activity
B4071_RS10745	COG0586	Pfam SNARE associated Golgi protein
B4071_RS10750	COG0688	phosphatidylethanolamine metabolic process
B4071_RS10760	COG2312	Erythromycin esterase
B4071_RS10765	COG1054	Belongs to the UPF0176 family
B4071_RS10770	COG1301	dicarboxylic acid transport
B4071_RS10775	COG2190	(PTS) system
B4071_RS10775	COG1263	PTS System
B4071_RS10775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4071_RS10780	COG0363	glucosamine-6-phosphate deaminase activity
B4071_RS10785	COG2188	Transcriptional regulator
B4071_RS10795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4071_RS10800	COG0833	amino acid
B4071_RS10805	COG2040	homocysteine
B4071_RS10815	COG1115	amino acid carrier protein
B4071_RS10820	COG2066	Belongs to the glutaminase family
B4071_RS10825	COG4191	Histidine kinase
B4071_RS10830	COG0784	Response regulator, receiver
B4071_RS10835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4071_RS10840	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS10850	COG4948	Mandelate Racemase Muconate Lactonizing
B4071_RS10855	COG2186	Transcriptional regulator
B4071_RS10875	COG0697	spore germination
B4071_RS10880	COG0745	RESPONSE REGULATOR receiver
B4071_RS10890	COG1131	(ABC) transporter
B4071_RS10910	COG3773	Cell wall hydrolase
B4071_RS10920	COG0072	phenylalanine-tRNA ligase activity
B4071_RS10920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4071_RS10950	COG0531	amino acid
B4071_RS10970	COG0137	argininosuccinate synthase activity
B4071_RS10975	COG0626	cystathionine gamma-synthase activity
B4071_RS10980	COG1279	arginine transmembrane transporter activity
B4071_RS10985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4071_RS11000	COG3540	Alkaline phosphatase
B4071_RS11005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4071_RS11010	COG0805	protein transport
B4071_RS11015	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B4071_RS11020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4071_RS11025	COG0477	Major facilitator Superfamily
B4071_RS11030	COG1309	transcriptional regulator
B4071_RS11035	COG0252	asparaginase activity
B4071_RS11040	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B4071_RS11045	COG1714	RDD family
B4071_RS11050	COG1405	negative regulation of cell septum assembly
B4071_RS11050	COG3012	SEC-C Motif Domain Protein
B4071_RS11055	COG3290	protein histidine kinase activity
B4071_RS11060	COG3279	Response regulator of the LytR AlgR family
B4071_RS11065	COG4555	ABC transporter
B4071_RS11070	COG1668	transmembrane transport
B4071_RS11085	COG1595	DNA-templated transcription, initiation
B4071_RS11090	COG1595	DNA-templated transcription, initiation
B4071_RS11095	COG1876	peptidase activity
B4071_RS11100	COG0457	Tetratricopeptide repeat
B4071_RS11105	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS11115	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4071_RS11120	COG1121	(ABC) transporter
B4071_RS11125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4071_RS11130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4071_RS11135	COG2310	stress, protein
B4071_RS11140	COG2310	stress, protein
B4071_RS11145	COG2310	stress, protein
B4071_RS11150	COG0861	Integral membrane protein TerC family
B4071_RS11160	COG3853	Toxic anion resistance protein (TelA)
B4071_RS11165	COG0477	Major facilitator Superfamily
B4071_RS11175	COG0640	Transcriptional regulator
B4071_RS11180	COG4175	Glycine betaine
B4071_RS11180	COG0517	IMP dehydrogenase activity
B4071_RS11185	COG4176	ABC-type proline glycine betaine transport system permease component
B4071_RS11190	COG2113	Glycine betaine
B4071_RS11195	COG1473	amidohydrolase
B4071_RS11200	COG1288	antiporter activity
B4071_RS11225	COG0516	GMP reductase activity
B4071_RS11225	COG0517	IMP dehydrogenase activity
B4071_RS11230	COG1686	Belongs to the peptidase S11 family
B4071_RS11235	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B4071_RS11240	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B4071_RS11245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B4071_RS11255	COG1428	Deoxynucleoside kinase
B4071_RS11260	COG1428	Deoxynucleoside kinase
B4071_RS11265	COG3858	chitin binding
B4071_RS11265	COG1388	LysM domain
B4071_RS11270	COG1335	isochorismatase
B4071_RS11275	COG0590	tRNA wobble adenosine to inosine editing
B4071_RS11280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4071_RS11285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B4071_RS11290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B4071_RS11340	COG0135	phosphoribosylanthranilate isomerase activity
B4071_RS11345	COG1525	nuclease
B4071_RS11350	COG2814	Major facilitator Superfamily
B4071_RS11355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4071_RS11365	COG0756	dUTP diphosphatase activity
B4071_RS11405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4071_RS11420	COG3832	glyoxalase III activity
B4071_RS11435	COG0697	spore germination
B4071_RS11440	COG0531	amino acid
B4071_RS11470	COG4195	phage-related replication protein
B4071_RS11480	COG0346	lactoylglutathione lyase activity
B4071_RS11490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4071_RS11495	COG1388	LysM domain
B4071_RS11500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4071_RS11505	COG4224	UPF0291 protein
B4071_RS11510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B4071_RS11520	COG3763	UPF0154 protein
B4071_RS11530	COG0785	Cytochrome C biogenesis protein
B4071_RS11535	COG2201	protein-glutamate methylesterase activity
B4071_RS11540	COG4846	Membrane protein involved in cytochrome C biogenesis
B4071_RS11550	COG0071	Belongs to the small heat shock protein (HSP20) family
B4071_RS11565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4071_RS11570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS11590	COG0824	Thioesterase
B4071_RS11600	COG4841	protein insertion into membrane
B4071_RS11605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B4071_RS11610	COG1832	CoA-binding protein
B4071_RS11615	COG0187	DNA topoisomerase II activity
B4071_RS11620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4071_RS11635	COG1115	amino acid carrier protein
B4071_RS11640	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4071_RS11655	COG3507	Belongs to the glycosyl hydrolase 43 family
B4071_RS11660	COG2246	polysaccharide biosynthetic process
B4071_RS11665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4071_RS11670	COG0586	Pfam SNARE associated Golgi protein
B4071_RS11675	COG2404	hydrolase activity, acting on ester bonds
B4071_RS11680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4071_RS11685	COG1024	Enoyl-CoA hydratase
B4071_RS11690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4071_RS11695	COG0511	ligase activity, forming carbon-carbon bonds
B4071_RS11700	COG0439	Biotin carboxylase
B4071_RS11705	COG0318	PFAM AMP-dependent synthetase and ligase
B4071_RS11710	COG1960	acyl-CoA dehydrogenase activity
B4071_RS11725	COG1649	PFAM Uncharacterised BCR, COG1649
B4071_RS11745	COG2027	D-alanyl-D-alanine carboxypeptidase
B4071_RS11750	COG2017	converts alpha-aldose to the beta-anomer
B4071_RS11755	COG0534	Mate efflux family protein
B4071_RS11770	COG0582	viral genome integration into host DNA
B4071_RS11775	COG0166	Belongs to the GPI family
B4071_RS11780	COG0405	Gamma-glutamyltransferase
B4071_RS11785	COG0583	DNA-binding transcription factor activity
B4071_RS11790	COG0604	alcohol dehydrogenase
B4071_RS11795	COG0493	'glutamate synthase
B4071_RS11800	COG0067	glutamate synthase
B4071_RS11800	COG0069	glutamate synthase activity
B4071_RS11800	COG0070	glutamate synthase
B4071_RS11805	COG0583	DNA-binding transcription factor activity
B4071_RS11810	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4071_RS11815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4071_RS11825	COG0300	oxidoreductase activity
B4071_RS11830	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4071_RS11840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4071_RS11855	COG1131	(ABC) transporter
B4071_RS11865	COG2814	Major facilitator Superfamily
B4071_RS11870	COG1070	Carbohydrate kinase
B4071_RS11875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4071_RS11880	COG0243	molybdopterin cofactor binding
B4071_RS11910	COG2368	4-hydroxyphenylacetate
B4071_RS11915	COG4305	rare lipoprotein A
B4071_RS11920	COG3619	membrane
B4071_RS11925	COG3866	Pectate lyase
B4071_RS11930	COG2135	peptidase activity
B4071_RS11960	COG2720	vancomycin resistance protein
B4071_RS11970	COG3655	Transcriptional regulator
B4071_RS11975	COG3739	integral membrane protein
B4071_RS11980	COG0583	DNA-binding transcription factor activity
B4071_RS11985	COG0697	spore germination
B4071_RS11995	COG4948	Mandelate Racemase Muconate Lactonizing
B4071_RS12000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4071_RS12005	COG1809	phosphosulfolactate synthase activity
B4071_RS12010	COG2045	Belongs to the ComB family
B4071_RS12025	COG0529	Catalyzes the synthesis of activated sulfate
B4071_RS12030	COG2267	carboxylic ester hydrolase activity
B4071_RS12035	COG1357	PFAM Pentapeptide repeats (8 copies)
B4071_RS12040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4071_RS12045	COG1279	arginine transmembrane transporter activity
B4071_RS12050	COG2318	DinB family
B4071_RS12055	COG0673	inositol 2-dehydrogenase activity
B4071_RS12065	COG1917	Cupin 2, conserved barrel domain protein
B4071_RS12065	COG2207	Transcriptional regulator
B4071_RS12070	COG0534	Mate efflux family protein
B4071_RS12075	COG1562	ergosterol biosynthetic process
B4071_RS12080	COG0367	asparagine synthase
B4071_RS12090	COG1404	Belongs to the peptidase S8 family
B4071_RS12100	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4071_RS12105	COG5337	Spore coat protein CotH
B4071_RS12150	COG1403	HNH endonuclease
B4071_RS12155	COG0419	ATPase involved in DNA repair
B4071_RS12165	COG0420	3'-5' exonuclease activity
B4071_RS12170	COG1074	ATP-dependent DNA helicase activity
B4071_RS12175	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B4071_RS12180	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B4071_RS12190	COG4533	DNA binding
B4071_RS12195	COG2814	Major facilitator Superfamily
B4071_RS12195	COG0477	Major facilitator Superfamily
B4071_RS12200	COG3180	Ammonia monooxygenase
B4071_RS12205	COG1609	Transcriptional regulator
B4071_RS12215	COG0561	phosphatase activity
B4071_RS12220	COG0673	inositol 2-dehydrogenase activity
B4071_RS12225	COG0738	Major facilitator superfamily
B4071_RS12230	COG1846	Transcriptional regulator
B4071_RS12235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4071_RS12240	COG0681	Belongs to the peptidase S26 family
B4071_RS12245	COG0398	Pfam SNARE associated Golgi protein
B4071_RS12260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4071_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS12275	COG4903	ComK protein
B4071_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS12295	COG0840	transmembrane signaling receptor activity
B4071_RS12300	COG1268	BioY protein
B4071_RS12305	COG0318	PFAM AMP-dependent synthetase and ligase
B4071_RS12310	COG0183	Belongs to the thiolase family
B4071_RS12315	COG0406	alpha-ribazole phosphatase activity
B4071_RS12320	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4071_RS12325	COG0604	alcohol dehydrogenase
B4071_RS12330	COG0456	acetyltransferase
B4071_RS12335	COG1404	Belongs to the peptidase S8 family
B4071_RS12340	COG0501	Belongs to the peptidase M48B family
B4071_RS12350	COG0318	PFAM AMP-dependent synthetase and ligase
B4071_RS12355	COG0702	epimerase
B4071_RS12360	COG0095	Lipoate-protein ligase
B4071_RS12365	COG1234	tRNA 3'-trailer cleavage
B4071_RS12375	COG1301	dicarboxylic acid transport
B4071_RS12380	COG4405	Protein conserved in bacteria
B4071_RS12385	COG1363	Peptidase, m42
B4071_RS12395	COG4377	Putative membrane peptidase family (DUF2324)
B4071_RS12400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4071_RS12405	COG1511	domain protein
B4071_RS12410	COG1309	transcriptional regulator
B4071_RS12415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B4071_RS12420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B4071_RS12425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4071_RS12430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4071_RS12435	COG2329	Antibiotic biosynthesis monooxygenase
B4071_RS12445	COG3069	C4-dicarboxylate transmembrane transporter activity
B4071_RS12450	COG1473	amidohydrolase
B4071_RS12460	COG4473	ABC transporter
B4071_RS12465	COG1131	(ABC) transporter
B4071_RS12470	COG0537	adenosine 5'-monophosphoramidase activity
B4071_RS12475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B4071_RS12490	COG4980	gas vesicle protein
B4071_RS12495	COG1846	Transcriptional regulator
B4071_RS12520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4071_RS12530	COG3481	metal-dependent phosphohydrolase, HD sub domain
B4071_RS12535	COG4717	serine-type aminopeptidase activity
B4071_RS12540	COG0420	3'-5' exonuclease activity
B4071_RS12545	COG1668	transmembrane transport
B4071_RS12550	COG4152	abc transporter atp-binding protein
B4071_RS12560	COG1024	Enoyl-CoA hydratase
B4071_RS12570	COG0490	domain, Protein
B4071_RS12575	COG0475	glutathione-regulated potassium exporter activity
B4071_RS12580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4071_RS12585	COG0561	phosphatase activity
B4071_RS12595	COG3679	Belongs to the UPF0342 family
B4071_RS12600	COG4399	Belongs to the UPF0754 family
B4071_RS12605	COG0189	ligase activity
B4071_RS12610	COG0189	ligase activity
B4071_RS12625	COG0702	epimerase
B4071_RS12630	COG1132	(ABC) transporter
B4071_RS12635	COG1132	(ABC) transporter
B4071_RS12645	COG0589	response to stress
B4071_RS12650	COG1757	Na H antiporter
B4071_RS12655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4071_RS12660	COG0726	polysaccharide deacetylase
B4071_RS12665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B4071_RS12670	COG0668	transmembrane transport
B4071_RS12680	COG0584	glycerophosphoryl diester phosphodiesterase
B4071_RS12685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4071_RS12690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4071_RS12695	COG1253	flavin adenine dinucleotide binding
B4071_RS12700	COG0436	Aminotransferase
B4071_RS12705	COG0789	Transcriptional regulator
B4071_RS12710	COG1253	flavin adenine dinucleotide binding
B4071_RS12715	COG0204	Acyl-transferase
B4071_RS12720	COG0667	Aldo Keto reductase
B4071_RS12725	COG1595	DNA-templated transcription, initiation
B4071_RS12740	COG0456	acetyltransferase
B4071_RS12745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4071_RS12750	COG0733	neurotransmitter:sodium symporter activity
B4071_RS12755	COG0531	amino acid
B4071_RS12760	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS12765	COG0372	Belongs to the citrate synthase family
B4071_RS12770	COG0583	DNA-binding transcription factor activity
B4071_RS12775	COG0791	NLP P60 protein
B4071_RS12775	COG1388	LysM domain
B4071_RS12780	COG1785	Belongs to the alkaline phosphatase family
B4071_RS12785	COG2719	SpoVR family
B4071_RS12790	COG0668	transmembrane transport
B4071_RS12795	COG1959	2 iron, 2 sulfur cluster binding
B4071_RS12800	COG0791	NLP P60 protein
B4071_RS12800	COG1388	LysM domain
B4071_RS12815	COG0431	NADPH-dependent FMN reductase
B4071_RS12820	COG2197	response regulator
B4071_RS12825	COG4585	Histidine kinase
B4071_RS12825	COG2203	Gaf domain
B4071_RS12830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4071_RS12835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4071_RS12840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4071_RS12845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4071_RS12850	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4071_RS12855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4071_RS12860	COG3153	acetyltransferase
B4071_RS12860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4071_RS12865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4071_RS12870	COG0517	IMP dehydrogenase activity
B4071_RS12880	COG0564	pseudouridine synthase activity
B4071_RS12885	COG3764	Sortase (surface protein transpeptidase)
B4071_RS12890	COG0737	Belongs to the 5'-nucleotidase family
B4071_RS12890	COG1525	nuclease
B4071_RS12890	COG4085	toxin activity
B4071_RS12895	COG5577	PFAM Coat F domain
B4071_RS12915	COG1823	symporter activity
B4071_RS12920	COG3706	GGDEF domain
B4071_RS12925	COG1464	Belongs to the NlpA lipoprotein family
B4071_RS12930	COG1278	Cold shock
B4071_RS12935	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4071_RS12940	COG1131	(ABC) transporter
B4071_RS12945	COG1131	(ABC) transporter
B4071_RS12950	COG1725	Transcriptional regulator
B4071_RS12965	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4071_RS12970	COG2814	Major facilitator Superfamily
B4071_RS12975	COG1566	PFAM secretion protein HlyD family protein
B4071_RS12980	COG1846	Transcriptional regulator
B4071_RS12990	COG2718	Belongs to the UPF0229 family
B4071_RS12995	COG2766	serine protein kinase
B4071_RS13000	COG1664	Polymer-forming cytoskeletal
B4071_RS13005	COG0789	Transcriptional regulator
B4071_RS13010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4071_RS13020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4071_RS13025	COG3382	B3 4 domain protein
B4071_RS13035	COG1476	TRANSCRIPTIONal
B4071_RS13045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4071_RS13055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4071_RS13065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4071_RS13070	COG1116	anion transmembrane transporter activity
B4071_RS13075	COG0753	catalase activity
B4071_RS13085	COG0277	FAD linked oxidase domain protein
B4071_RS13090	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B4071_RS13095	COG3340	Belongs to the peptidase S51 family
B4071_RS13100	COG5577	PFAM Coat F domain
B4071_RS13110	COG4326	sporulation control protein
B4071_RS13140	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B4071_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS13155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4071_RS13155	COG3711	transcriptional antiterminator
B4071_RS13160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4071_RS13160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4071_RS13160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4071_RS13165	COG1482	cell wall glycoprotein biosynthetic process
B4071_RS13180	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B4071_RS13190	COG0483	inositol monophosphate 1-phosphatase activity
B4071_RS13200	COG4493	Belongs to the UPF0637 family
B4071_RS13205	COG4476	Belongs to the UPF0223 family
B4071_RS13210	COG1982	Orn Lys Arg decarboxylase major
B4071_RS13215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS13220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4071_RS13225	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4071_RS13230	COG0022	dehydrogenase e1 component
B4071_RS13235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4071_RS13240	COG0497	DNA recombination
B4071_RS13250	COG0242	peptide deformylase activity
B4071_RS13255	COG0561	phosphatase activity
B4071_RS13260	COG5503	Protein of unknown function (DUF1447)
B4071_RS13265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4071_RS13270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4071_RS13275	COG0569	domain protein
B4071_RS13280	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B4071_RS13280	COG2105	PFAM AIG2 family protein
B4071_RS13285	COG3852	Histidine kinase
B4071_RS13290	COG2002	toxin-antitoxin pair type II binding
B4071_RS13295	COG1077	Cell shape determining protein MreB Mrl
B4071_RS13305	COG2309	aminopeptidase activity
B4071_RS13310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4071_RS13315	COG0488	(ABC) transporter
B4071_RS13325	COG0681	Belongs to the peptidase S26 family
B4071_RS13330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4071_RS13330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4071_RS13330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4071_RS13335	COG1105	Belongs to the carbohydrate kinase PfkB family
B4071_RS13340	COG1349	DNA-binding transcription factor activity
B4071_RS13345	COG0577	efflux transmembrane transporter activity
B4071_RS13350	COG1136	(ABC) transporter
B4071_RS13355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4071_RS13365	COG1132	(ABC) transporter
B4071_RS13370	COG1132	(ABC) transporter
B4071_RS13375	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B4071_RS13380	COG0314	molybdopterin synthase activity
B4071_RS13385	COG1763	Mo-molybdopterin cofactor biosynthetic process
B4071_RS13390	COG0303	'Molybdopterin
B4071_RS13395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4071_RS13400	COG0746	molybdenum cofactor guanylyltransferase activity
B4071_RS13410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4071_RS13420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4071_RS13435	COG0109	protoheme IX farnesyltransferase activity
B4071_RS13445	COG0726	polysaccharide deacetylase
B4071_RS13455	COG1510	regulation of RNA biosynthetic process
B4071_RS13460	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS13465	COG1454	alcohol dehydrogenase
B4071_RS13475	COG2318	DinB family
B4071_RS13480	COG1585	Membrane protein implicated in regulation of membrane protease activity
B4071_RS13485	COG2268	Band 7 protein
B4071_RS13490	COG1247	-acetyltransferase
B4071_RS13495	COG3859	Proton-coupled thiamine transporter YuaJ
B4071_RS13510	COG1793	dna ligase
B4071_RS13545	COG4474	Belongs to the UPF0398 family
B4071_RS13575	COG1595	DNA-templated transcription, initiation
B4071_RS13595	COG1217	gtp-binding protein TYPA
B4071_RS13605	COG4896	Protein conserved in bacteria
B4071_RS13615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B4071_RS13620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4071_RS13625	COG2066	Belongs to the glutaminase family
B4071_RS13630	COG4838	Belongs to the UPF0358 family
B4071_RS13635	COG0772	Belongs to the SEDS family
B4071_RS13640	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B4071_RS13645	COG1612	heme a metabolic process
B4071_RS13650	COG0109	protoheme IX farnesyltransferase activity
B4071_RS13655	COG2010	Cytochrome c
B4071_RS13655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4071_RS13660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4071_RS13665	COG1845	cytochrome c oxidase, subunit III
B4071_RS13670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B4071_RS13675	COG3336	cytochrome c oxidase
B4071_RS13685	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B4071_RS13690	COG2340	Cysteine-rich secretory protein family
B4071_RS13705	COG3679	Belongs to the UPF0342 family
B4071_RS13710	COG4471	UPF0298 protein
B4071_RS13715	COG0742	ribosomal rna small subunit methyltransferase
B4071_RS13720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B4071_RS13725	COG3314	Sporulation integral membrane protein YlbJ
B4071_RS13730	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4071_RS13735	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4071_RS13740	COG1323	Belongs to the UPF0348 family
B4071_RS13750	COG1399	metal-binding, possibly nucleic acid-binding protein
B4071_RS13765	COG0454	-acetyltransferase
B4071_RS13770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4071_RS13775	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B4071_RS13780	COG2001	Belongs to the MraZ family
B4071_RS13785	COG0275	rRNA processing
B4071_RS13790	COG4839	cell division protein FtsL
B4071_RS13795	COG0768	penicillin binding
B4071_RS13805	COG0768	penicillin binding
B4071_RS13815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4071_RS13825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4071_RS13830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4071_RS13835	COG0772	Belongs to the SEDS family
B4071_RS13840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4071_RS13845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B4071_RS13850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4071_RS13855	COG3879	Bacterial protein of unknown function (DUF881)
B4071_RS13860	COG3879	Bacterial protein of unknown function (DUF881)
B4071_RS13865	COG3856	small basic protein
B4071_RS13870	COG0849	cell division
B4071_RS13875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B4071_RS13880	COG1404	Belongs to the peptidase S8 family
B4071_RS13880	COG4412	M6 family metalloprotease domain protein
B4071_RS13890	COG1191	sigma factor activity
B4071_RS13895	COG1191	sigma factor activity
B4071_RS13900	COG1119	ATPase activity
B4071_RS13905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4071_RS13910	COG1873	PFAM PRC-barrel domain
B4071_RS13915	COG1496	oxidoreductase activity
B4071_RS13920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4071_RS13925	COG1799	cell septum assembly
B4071_RS13930	COG0762	integral membrane protein
B4071_RS13935	COG2302	S4 RNA-binding domain
B4071_RS13940	COG3599	regulation of cell shape
B4071_RS13945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B4071_RS13950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4071_RS13955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B4071_RS13960	COG0564	pseudouridine synthase activity
B4071_RS13965	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B4071_RS13970	COG2233	PERMEase
B4071_RS13975	COG0540	Belongs to the ATCase OTCase family
B4071_RS13980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4071_RS13985	COG0505	Belongs to the CarA family
B4071_RS13990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4071_RS13995	COG0543	2 iron, 2 sulfur cluster binding
B4071_RS14000	COG0167	dihydroorotate dehydrogenase activity
B4071_RS14005	COG0284	orotidine-5'-phosphate decarboxylase activity
B4071_RS14010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B4071_RS14020	COG0175	sulfate reduction
B4071_RS14025	COG0306	phosphate transporter
B4071_RS14030	COG2046	Belongs to the sulfate adenylyltransferase family
B4071_RS14035	COG0529	Catalyzes the synthesis of activated sulfate
B4071_RS14040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4071_RS14045	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B4071_RS14050	COG1648	precorrin-2 dehydrogenase activity
B4071_RS14055	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B4071_RS14060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4071_RS14065	COG1561	YicC-like family, N-terminal region
B4071_RS14075	COG0194	GDP metabolic process
B4071_RS14080	COG1758	RNA polymerase activity
B4071_RS14085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4071_RS14090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4071_RS14095	COG0242	peptide deformylase activity
B4071_RS14100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4071_RS14105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4071_RS14105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4071_RS14110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B4071_RS14115	COG0631	protein serine/threonine phosphatase activity
B4071_RS14120	COG2815	serine threonine protein kinase
B4071_RS14120	COG0515	serine threonine protein kinase
B4071_RS14125	COG1162	GTPase activity
B4071_RS14130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4071_RS14135	COG1564	THIamine pyrophosphokinase
B4071_RS14145	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B4071_RS14150	COG1302	Protein conserved in bacteria
B4071_RS14155	COG1461	Dihydroxyacetone kinase
B4071_RS14160	COG1760	l-serine dehydratase
B4071_RS14165	COG1760	l-serine dehydratase
B4071_RS14170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4071_RS14175	COG2050	protein possibly involved in aromatic compounds catabolism
B4071_RS14175	COG1349	DNA-binding transcription factor activity
B4071_RS14180	COG0416	fatty acid biosynthetic process
B4071_RS14185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4071_RS14190	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS14200	COG0571	ribonuclease III activity
B4071_RS14205	COG1196	nuclear chromosome segregation
B4071_RS14210	COG0552	protein localization to endoplasmic reticulum
B4071_RS14220	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B4071_RS14225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4071_RS14230	COG0228	four-way junction DNA binding
B4071_RS14235	COG1837	Belongs to the UPF0109 family
B4071_RS14245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B4071_RS14250	COG0336	Belongs to the RNA methyltransferase TrmD family
B4071_RS14255	COG0335	large ribosomal subunit rRNA binding
B4071_RS14260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4071_RS14265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4071_RS14275	COG2257	FlhB HrpN YscU SpaS Family
B4071_RS14280	COG0045	succinate-CoA ligase (ADP-forming) activity
B4071_RS14285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4071_RS14290	COG0758	DNA mediated transformation
B4071_RS14295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4071_RS14300	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B4071_RS14305	COG4974	Belongs to the 'phage' integrase family
B4071_RS14310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B4071_RS14315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B4071_RS14320	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B4071_RS14325	COG1815	bacterial-type flagellum-dependent cell motility
B4071_RS14330	COG1558	bacterial-type flagellum-dependent cell motility
B4071_RS14335	COG1677	Flagellar hook-basal body complex protein FliE
B4071_RS14340	COG1766	The M ring may be actively involved in energy transduction
B4071_RS14345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4071_RS14350	COG1317	bacterial-type flagellum organization
B4071_RS14355	COG1157	protein secretion by the type III secretion system
B4071_RS14360	COG2882	bacterial-type flagellum organization
B4071_RS14365	COG3334	PFAM MgtE intracellular
B4071_RS14370	COG3144	bacterial-type flagellum assembly
B4071_RS14375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B4071_RS14380	COG4786	Flagellar basal body rod
B4071_RS14385	COG1582	Flagellar protein (FlbD)
B4071_RS14390	COG1580	Controls the rotational direction of flagella during chemotaxis
B4071_RS14395	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4071_RS14400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4071_RS14400	COG1776	CheC inhibitor of MCP methylation
B4071_RS14405	COG2201	protein-glutamate methylesterase activity
B4071_RS14410	COG3190	flagellar
B4071_RS14415	COG1338	Plays a role in the flagellum-specific transport system
B4071_RS14420	COG1987	bacterial-type flagellum assembly
B4071_RS14425	COG1684	flagellar biosynthetic protein fliR
B4071_RS14430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4071_RS14435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4071_RS14440	COG1419	protein localization to endoplasmic reticulum
B4071_RS14445	COG0455	bacterial-type flagellum organization
B4071_RS14450	COG2201	protein-glutamate methylesterase activity
B4071_RS14455	COG0643	Histidine kinase
B4071_RS14455	COG2198	Histidine kinase
B4071_RS14460	COG0835	chemotaxis
B4071_RS14465	COG1776	CheC inhibitor of MCP methylation
B4071_RS14470	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B4071_RS14475	COG1191	sigma factor activity
B4071_RS14485	COG0052	Belongs to the universal ribosomal protein uS2 family
B4071_RS14490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B4071_RS14495	COG0528	UMP kinase activity
B4071_RS14500	COG0233	cytoplasmic translational termination
B4071_RS14505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B4071_RS14510	COG4589	Belongs to the CDS family
B4071_RS14515	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B4071_RS14520	COG0750	zinc metalloprotease
B4071_RS14525	COG0442	prolyl-tRNA aminoacylation
B4071_RS14530	COG2176	DNA-directed DNA polymerase activity
B4071_RS14535	COG0779	Required for maturation of 30S ribosomal subunits
B4071_RS14540	COG0195	Participates in both transcription termination and antitermination
B4071_RS14545	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4071_RS14550	COG1358	cellular component organization or biogenesis
B4071_RS14555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B4071_RS14560	COG1550	Protein conserved in bacteria
B4071_RS14565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B4071_RS14570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B4071_RS14575	COG0196	riboflavin kinase activity
B4071_RS14580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4071_RS14585	COG1185	polyribonucleotide nucleotidyltransferase activity
B4071_RS14590	COG0726	polysaccharide deacetylase
B4071_RS14595	COG0612	Peptidase, M16
B4071_RS14600	COG1873	PFAM PRC-barrel domain
B4071_RS14610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4071_RS14615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4071_RS14620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4071_RS14625	COG0527	aspartate kinase activity
B4071_RS14630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4071_RS14635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4071_RS14640	COG0740	serine-type endopeptidase activity
B4071_RS14650	COG1674	ftsk spoiiie
B4071_RS14650	COG4980	gas vesicle protein
B4071_RS14655	COG2188	Transcriptional regulator
B4071_RS14660	COG2814	Major facilitator Superfamily
B4071_RS14665	COG0612	Peptidase, M16
B4071_RS14670	COG0612	Peptidase, M16
B4071_RS14675	COG0300	oxidoreductase activity
B4071_RS14690	COG1426	Protein conserved in bacteria
B4071_RS14695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4071_RS14700	COG1058	Belongs to the CinA family
B4071_RS14700	COG1546	Belongs to the CinA family
B4071_RS14705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B4071_RS14710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4071_RS14715	COG1418	mRNA catabolic process
B4071_RS14720	COG1692	metallophosphoesterase
B4071_RS14725	COG2359	stage V sporulation protein S
B4071_RS14730	COG1063	alcohol dehydrogenase
B4071_RS14735	COG0156	8-amino-7-oxononanoate synthase activity
B4071_RS14740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4071_RS14745	COG4550	Control of competence regulator ComK, YlbF/YmcA
B4071_RS14755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B4071_RS14760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B4071_RS14780	COG3226	Transcriptional regulator
B4071_RS14790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4071_RS14795	COG1404	Belongs to the peptidase S8 family
B4071_RS14805	COG4195	phage-related replication protein
B4071_RS14810	COG1764	response to oxidative stress
B4071_RS14815	COG2076	Multidrug Resistance protein
B4071_RS14820	COG2076	Multidrug Resistance protein
B4071_RS14835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B4071_RS14840	COG1923	regulation of RNA biosynthetic process
B4071_RS14855	COG1780	Probably involved in ribonucleotide reductase function
B4071_RS14860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4071_RS14865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4071_RS14870	COG4112	unkown
B4071_RS14875	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4071_RS14880	COG0464	growth
B4071_RS14890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4071_RS14895	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B4071_RS14900	COG0789	Transcriptional regulator
B4071_RS14905	COG0174	glutamine synthetase
B4071_RS14915	COG5444	nuclease activity
B4071_RS14945	COG5577	PFAM Coat F domain
B4071_RS14950	COG0789	Transcriptional regulator
B4071_RS14955	COG1064	alcohol dehydrogenase
B4071_RS14960	COG0693	protein deglycase activity
B4071_RS14965	COG1621	beta-fructofuranosidase activity
B4071_RS14970	COG3716	PTS system mannose fructose sorbose family IID component
B4071_RS14975	COG3715	PTS system
B4071_RS14980	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4071_RS14985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4071_RS14990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B4071_RS14990	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B4071_RS14995	COG1113	amino acid transport
B4071_RS15000	COG1280	lysine exporter protein (LysE YggA)
B4071_RS15005	COG1378	Sugar-specific transcriptional regulator TrmB
B4071_RS15010	COG1595	DNA-templated transcription, initiation
B4071_RS15020	COG2755	lipolytic protein G-D-S-L family
B4071_RS15020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B4071_RS15030	COG2124	cytochrome p450
B4071_RS15030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4071_RS15035	COG1309	transcriptional regulator
B4071_RS15040	COG2226	methyltransferase
B4071_RS15050	COG2116	formate transmembrane transporter activity
B4071_RS15055	COG5609	conserved protein (DUF2294)
B4071_RS15060	COG3383	formate dehydrogenase (NAD+) activity
B4071_RS15065	COG2427	Protein of unknown function (DUF1641)
B4071_RS15075	COG0626	cystathionine gamma-synthase activity
B4071_RS15080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4071_RS15085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4071_RS15090	COG2226	methyltransferase
B4071_RS15105	COG0768	penicillin binding
B4071_RS15110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4071_RS15115	COG0572	uridine kinase
B4071_RS15120	COG0826	peptidase U32
B4071_RS15125	COG0826	peptidase U32
B4071_RS15130	COG4122	O-methyltransferase activity
B4071_RS15135	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4071_RS15140	COG3906	Belongs to the UPF0473 family
B4071_RS15145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B4071_RS15150	COG4472	Bacterial protein of unknown function (DUF965)
B4071_RS15155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4071_RS15160	COG0628	permease
B4071_RS15165	COG1126	abc transporter atp-binding protein
B4071_RS15170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4071_RS15175	COG0765	amino acid transport
B4071_RS15180	COG0765	amino acid transport
B4071_RS15195	COG3881	PFAM PRC-barrel domain
B4071_RS15200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4071_RS15205	COG0457	Tetratricopeptide repeat
B4071_RS15210	COG0482	sulfurtransferase activity
B4071_RS15215	COG1104	cysteine desulfurase activity
B4071_RS15220	COG1959	2 iron, 2 sulfur cluster binding
B4071_RS15225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4071_RS15230	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4071_RS15240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B4071_RS15245	COG0124	histidyl-tRNA synthetase
B4071_RS15255	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4071_RS15255	COG4991	sh3 domain protein
B4071_RS15255	COG3103	Sh3 type 3 domain protein
B4071_RS15260	COG1490	D-aminoacyl-tRNA deacylase activity
B4071_RS15265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4071_RS15270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4071_RS15275	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4071_RS15275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4071_RS15280	COG5416	Lipopolysaccharide assembly protein A domain
B4071_RS15285	COG0490	domain, Protein
B4071_RS15290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4071_RS15290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4071_RS15300	COG2244	polysaccharide biosynthetic process
B4071_RS15305	COG2323	membrane
B4071_RS15315	COG1862	Preprotein translocase
B4071_RS15320	COG0343	queuine tRNA-ribosyltransferase activity
B4071_RS15325	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B4071_RS15335	COG2255	four-way junction helicase activity
B4071_RS15340	COG0632	four-way junction helicase activity
B4071_RS15350	COG2814	Major facilitator Superfamily
B4071_RS15355	COG0673	inositol 2-dehydrogenase activity
B4071_RS15360	COG2112	serine threonine protein kinase
B4071_RS15380	COG1115	amino acid carrier protein
B4071_RS15385	COG0217	transcriptional regulatory protein
B4071_RS15395	COG1388	LysM domain
B4071_RS15400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B4071_RS15405	COG0157	Belongs to the NadC ModD family
B4071_RS15410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4071_RS15415	COG1104	cysteine desulfurase activity
B4071_RS15420	COG1827	regulation of RNA biosynthetic process
B4071_RS15425	COG0077	Prephenate dehydratase
B4071_RS15430	COG4492	Belongs to the UPF0735 family
B4071_RS15435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B4071_RS15440	COG3290	protein histidine kinase activity
B4071_RS15450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B4071_RS15455	COG2868	ribosomal protein
B4071_RS15460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B4071_RS15465	COG1994	Peptidase M50
B4071_RS15470	COG0739	heme binding
B4071_RS15475	COG2894	cell division
B4071_RS15480	COG0850	regulation of cytokinetic process
B4071_RS15485	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B4071_RS15495	COG1077	Cell shape determining protein MreB Mrl
B4071_RS15500	COG2003	Belongs to the UPF0758 family
B4071_RS15545	COG3409	Peptidoglycan-binding domain 1 protein
B4071_RS15545	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4071_RS15550	COG4824	toxin secretion phage lysis holin
B4071_RS15565	COG5434	Belongs to the glycosyl hydrolase 28 family
B4071_RS15570	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4071_RS15580	COG3953	SLT domain
B4071_RS15580	COG5280	Phage tail tape measure protein TP901
B4071_RS15640	COG4626	Terminase
B4071_RS15640	COG1802	Transcriptional regulator
B4071_RS15685	COG1595	DNA-templated transcription, initiation
B4071_RS15705	COG0305	Participates in initiation and elongation during chromosome replication
B4071_RS15730	COG3645	SOS response
B4071_RS15730	COG3646	Phage regulatory protein
B4071_RS15755	COG1396	sequence-specific DNA binding
B4071_RS15775	COG0424	maF-like protein
B4071_RS15785	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4071_RS15790	COG0285	dihydrofolate synthase activity
B4071_RS15795	COG0525	valine-tRNA ligase activity
B4071_RS15805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4071_RS15810	COG1388	LysM domain
B4071_RS15815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4071_RS15820	COG0113	porphobilinogen synthase activity
B4071_RS15825	COG1587	Uroporphyrinogen-III synthase
B4071_RS15830	COG0181	hydroxymethylbilane synthase activity
B4071_RS15835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4071_RS15840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B4071_RS15850	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B4071_RS15855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4071_RS15860	COG1067	ATP-dependent peptidase activity
B4071_RS15860	COG0470	DNA polymerase III
B4071_RS15865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B4071_RS15870	COG0544	peptidyl-prolyl cis-trans isomerase activity
B4071_RS15875	COG0457	Tetratricopeptide repeat
B4071_RS15875	COG1477	protein flavinylation
B4071_RS15880	COG0066	3-isopropylmalate dehydratase activity
B4071_RS15885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4071_RS15890	COG0473	3-isopropylmalate dehydrogenase activity
B4071_RS15895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4071_RS15900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B4071_RS15905	COG0440	acetolactate synthase activity
B4071_RS15910	COG0028	Belongs to the TPP enzyme family
B4071_RS15920	COG0454	-acetyltransferase
B4071_RS15930	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
B4071_RS15940	COG0622	Phosphoesterase
B4071_RS15945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B4071_RS15950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B4071_RS15955	COG5401	PFAM Sporulation and spore germination
B4071_RS15960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B4071_RS15965	COG1846	Transcriptional regulator
B4071_RS15970	COG2197	response regulator
B4071_RS15975	COG0824	Thioesterase
B4071_RS15980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4071_RS15985	COG1053	succinate dehydrogenase
B4071_RS15990	COG2009	succinate dehydrogenase
B4071_RS16000	COG1719	4-vinyl reductase, 4VR
B4071_RS16005	COG0527	aspartate kinase activity
B4071_RS16010	COG0322	excinuclease ABC activity
B4071_RS16015	COG3118	belongs to the thioredoxin family
B4071_RS16020	COG3534	alpha-L-arabinofuranosidase
B4071_RS16025	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B4071_RS16030	COG2086	electron transfer activity
B4071_RS16035	COG1024	Enoyl-CoA hydratase
B4071_RS16040	COG1309	transcriptional regulator
B4071_RS16045	COG0318	PFAM AMP-dependent synthetase and ligase
B4071_RS16050	COG3766	membrane
B4071_RS16055	COG1193	negative regulation of DNA recombination
B4071_RS16060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4071_RS16060	COG1796	DNA polymerase
B4071_RS16065	COG1286	toxin biosynthetic process
B4071_RS16070	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B4071_RS16075	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4071_RS16080	COG0072	phenylalanine-tRNA ligase activity
B4071_RS16080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4071_RS16085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B4071_RS16095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4071_RS16105	COG3835	regulator
B4071_RS16110	COG0277	FAD linked oxidase domain protein
B4071_RS16115	COG0247	lactate metabolic process
B4071_RS16120	COG0346	lactoylglutathione lyase activity
B4071_RS16125	COG1966	Carbon starvation protein
B4071_RS16130	COG3534	alpha-L-arabinofuranosidase
B4071_RS16135	COG0395	ABC-type sugar transport system, permease component
B4071_RS16140	COG1175	transmembrane transport
B4071_RS16145	COG1653	transport
B4071_RS16150	COG0371	Dehydrogenase
B4071_RS16155	COG0647	UMP catabolic process
B4071_RS16160	COG0235	Class ii aldolase
B4071_RS16165	COG1069	ribulokinase activity
B4071_RS16170	COG2160	L-arabinose isomerase activity
B4071_RS16175	COG3507	Belongs to the glycosyl hydrolase 43 family
B4071_RS16180	COG1363	Peptidase, m42
B4071_RS16190	COG3326	Membrane
B4071_RS16195	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B4071_RS16200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B4071_RS16205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4071_RS16215	COG1346	cytolysis
B4071_RS16220	COG1380	Effector of murein hydrolase LrgA
B4071_RS16225	COG3279	Response regulator of the LytR AlgR family
B4071_RS16230	COG3275	phosphorelay sensor kinase activity
B4071_RS16235	COG1011	Hydrolase
B4071_RS16240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4071_RS16250	COG0398	Pfam SNARE associated Golgi protein
B4071_RS16255	COG1484	DNA-dependent DNA replication
B4071_RS16260	COG3611	Membrane attachment protein
B4071_RS16265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B4071_RS16270	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4071_RS16275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4071_RS16285	COG2814	Major facilitator Superfamily
B4071_RS16290	COG0656	L-ascorbic acid biosynthetic process
B4071_RS16295	COG0693	protein deglycase activity
B4071_RS16310	COG5444	nuclease activity
B4071_RS16315	COG4282	regulation of fungal-type cell wall biogenesis
B4071_RS16320	COG1231	oxidoreductase activity
B4071_RS16330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4071_RS16335	COG2207	Transcriptional regulator
B4071_RS16335	COG0662	Cupin 2, conserved barrel domain protein
B4071_RS16340	COG0456	acetyltransferase
B4071_RS16345	COG1309	transcriptional regulator
B4071_RS16350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4071_RS16355	COG3708	Transcriptional regulator
B4071_RS16360	COG2378	regulation of single-species biofilm formation
B4071_RS16370	COG0640	Transcriptional regulator
B4071_RS16375	COG0741	lytic transglycosylase activity
B4071_RS16385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4071_RS16390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4071_RS16395	COG0300	oxidoreductase activity
B4071_RS16400	COG3048	D-serine ammonia-lyase activity
B4071_RS16405	COG1072	(Pantothenic acid kinase))
B4071_RS16410	COG0346	lactoylglutathione lyase activity
B4071_RS16420	COG2211	Major facilitator Superfamily
B4071_RS16430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4071_RS16440	COG0456	acetyltransferase
B4071_RS16445	COG2329	Antibiotic biosynthesis monooxygenase
B4071_RS16450	COG0456	acetyltransferase
B4071_RS16450	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B4071_RS16455	COG4918	Iron-sulphur cluster biosynthesis
B4071_RS16465	COG1073	alpha beta
B4071_RS16475	COG0667	Aldo Keto reductase
B4071_RS16485	COG0494	nUDIX hydrolase
B4071_RS16490	COG1379	DNA repair
B4071_RS16495	COG1396	sequence-specific DNA binding
B4071_RS16500	COG0252	asparaginase activity
B4071_RS16505	COG1027	Aspartate ammonia-lyase
B4071_RS16510	COG1757	Na H antiporter
B4071_RS16515	COG0281	malic enzyme
B4071_RS16525	COG1300	Membrane
B4071_RS16530	COG0735	belongs to the Fur family
B4071_RS16540	COG4974	Belongs to the 'phage' integrase family
B4071_RS16545	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B4071_RS16550	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B4071_RS16555	COG1686	Belongs to the peptidase S11 family
B4071_RS16560	COG1366	Belongs to the anti-sigma-factor antagonist family
B4071_RS16565	COG2172	sigma factor antagonist activity
B4071_RS16570	COG1191	sigma factor activity
B4071_RS16590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4071_RS16605	COG0697	spore germination
B4071_RS16610	COG0019	diaminopimelate decarboxylase activity
B4071_RS16615	COG4086	secreted protein
B4071_RS16620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4071_RS16650	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
B4071_RS16660	COG0681	Belongs to the peptidase S26 family
B4071_RS16670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4071_RS16670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4071_RS16675	COG0307	riboflavin synthase, alpha
B4071_RS16680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4071_RS16680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4071_RS16685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B4071_RS16690	COG0456	acetyltransferase
B4071_RS16695	COG1547	Domain of unknown function (DUF309)
B4071_RS16700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B4071_RS16705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B4071_RS16715	COG1686	Belongs to the peptidase S11 family
B4071_RS16720	COG2715	membrane protein required for spore maturation
B4071_RS16725	COG0700	Nucleoside recognition
B4071_RS16730	COG1187	pseudouridine synthase activity
B4071_RS16735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS16740	COG1333	cytochrome c biogenesis protein
B4071_RS16745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4071_RS16750	COG0745	RESPONSE REGULATOR receiver
B4071_RS16755	COG5002	protein histidine kinase activity
B4071_RS16760	COG1595	DNA-templated transcription, initiation
B4071_RS16770	COG0710	3-dehydroquinate dehydratase activity
B4071_RS16775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4071_RS16785	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B4071_RS16790	COG1141	Ferredoxin
B4071_RS16795	COG4955	Helix-turn-helix domain
B4071_RS16800	COG0514	ATP-dependent DNA helicase (RecQ)
B4071_RS16805	COG1266	CAAX protease self-immunity
B4071_RS16810	COG1388	LysM domain
B4071_RS16820	COG1408	metallophosphoesterase
B4071_RS16825	COG4862	establishment of competence for transformation
B4071_RS16830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4071_RS16835	COG0492	ferredoxin-NADP+ reductase activity
B4071_RS16840	COG2339	peptidase activity
B4071_RS16845	COG3773	Cell wall hydrolase
B4071_RS16845	COG3409	Peptidoglycan-binding domain 1 protein
B4071_RS16850	COG2959	enzyme of heme biosynthesis
B4071_RS16855	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B4071_RS16865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B4071_RS16870	COG0539	negative regulation of cytoplasmic translation
B4071_RS16875	COG1304	FMN binding
B4071_RS16900	COG1160	GTP binding
B4071_RS16905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B4071_RS16920	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4071_RS16925	COG0776	regulation of translation
B4071_RS16930	COG0302	gtp cyclohydrolase
B4071_RS16940	COG0142	geranyltranstransferase activity
B4071_RS16945	COG2226	methyltransferase
B4071_RS16950	COG0142	geranyltranstransferase activity
B4071_RS16955	COG0105	UTP biosynthetic process
B4071_RS16965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4071_RS16970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B4071_RS16975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B4071_RS16980	COG4401	Chorismate mutase type I
B4071_RS16985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4071_RS16990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4071_RS17000	COG0135	phosphoribosylanthranilate isomerase activity
B4071_RS17005	COG0133	tryptophan synthase activity
B4071_RS17010	COG0159	tryptophan synthase activity
B4071_RS17020	COG0287	Prephenate dehydrogenase
B4071_RS17025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4071_RS17030	COG0457	Tetratricopeptide repeat
B4071_RS17035	COG5582	Belongs to the UPF0302 family
B4071_RS17045	COG0723	plastoquinol--plastocyanin reductase activity
B4071_RS17050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4071_RS17055	COG2010	Cytochrome c
B4071_RS17055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4071_RS17060	COG4347	Protein of unknown function (DUF1405)
B4071_RS17070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4071_RS17075	COG1694	Mazg nucleotide pyrophosphohydrolase
B4071_RS17080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B4071_RS17085	COG1803	Methylglyoxal synthase
B4071_RS17090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4071_RS17095	COG0438	transferase activity, transferring glycosyl groups
B4071_RS17100	COG0617	tRNA 3'-terminal CCA addition
B4071_RS17105	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B4071_RS17105	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B4071_RS17110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B4071_RS17115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B4071_RS17120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B4071_RS17125	COG1199	ATP-dependent helicase activity
B4071_RS17125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4071_RS17135	COG5353	protein conserved in bacteria
B4071_RS17140	COG0436	Aminotransferase
B4071_RS17145	COG0017	Asparaginyl-tRNA synthetase
B4071_RS17150	COG3935	DnaD domain protein
B4071_RS17155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4071_RS17165	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4071_RS17165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4071_RS17170	COG3331	DNA recombination
B4071_RS17205	COG0071	Belongs to the small heat shock protein (HSP20) family
B4071_RS17210	COG2190	(PTS) system
B4071_RS17215	COG1111	helicase
B4071_RS17215	COG1205	dead DEAH box helicase
B4071_RS17220	COG3359	exonuclease
B4071_RS17230	COG4474	Belongs to the UPF0398 family
B4071_RS17240	COG0116	Belongs to the methyltransferase superfamily
B4071_RS17250	COG1199	ATP-dependent helicase activity
B4071_RS17255	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS17260	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B4071_RS17265	COG1609	Transcriptional regulator
B4071_RS17270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4071_RS17275	COG0800	Aldolase
B4071_RS17285	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B4071_RS17290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4071_RS17295	COG2233	PERMEase
B4071_RS17300	COG3424	synthase
B4071_RS17305	COG1755	Isoprenylcysteine carboxyl methyltransferase
B4071_RS17310	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4071_RS17330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4071_RS17340	COG0328	RNA-DNA hybrid ribonuclease activity
B4071_RS17345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4071_RS17350	COG0328	RNA-DNA hybrid ribonuclease activity
B4071_RS17370	COG1278	Cold shock
B4071_RS17375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4071_RS17380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B4071_RS17385	COG0386	Belongs to the glutathione peroxidase family
B4071_RS17395	COG1413	lyase activity
B4071_RS17400	COG0129	dihydroxy-acid dehydratase activity
B4071_RS17410	COG2136	Putative SAM-dependent methyltransferase
B4071_RS17410	COG2521	methyltransferase
B4071_RS17420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4071_RS17425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B4071_RS17430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4071_RS17435	COG0204	Acyl-transferase
B4071_RS17440	COG1272	protein, Hemolysin III
B4071_RS17445	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B4071_RS17450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4071_RS17465	COG1999	signal sequence binding
B4071_RS17470	COG2755	lipolytic protein G-D-S-L family
B4071_RS17475	COG4698	Protein conserved in bacteria
B4071_RS17485	COG0534	Mate efflux family protein
B4071_RS17490	COG1846	Transcriptional regulator
B4071_RS17495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4071_RS17500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4071_RS17505	COG1086	Polysaccharide biosynthesis protein
B4071_RS17510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4071_RS17530	COG1525	nuclease
B4071_RS17540	COG4282	regulation of fungal-type cell wall biogenesis
B4071_RS17545	COG5444	nuclease activity
B4071_RS17565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4071_RS17595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4071_RS17610	COG2274	protein secretion by the type I secretion system
B4071_RS17610	COG3271	cysteine-type peptidase activity
B4071_RS17615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS17620	COG0463	Glycosyl transferase, family 2
B4071_RS17625	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4071_RS17640	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4071_RS17660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4071_RS17680	COG0400	carboxylic ester hydrolase activity
B4071_RS17685	COG0346	lactoylglutathione lyase activity
B4071_RS17695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4071_RS17700	COG3409	Peptidoglycan-binding domain 1 protein
B4071_RS17700	COG0793	Belongs to the peptidase S41A family
B4071_RS17705	COG2226	methyltransferase
B4071_RS17715	COG1876	peptidase activity
B4071_RS17720	COG0813	purine-nucleoside phosphorylase activity
B4071_RS17735	COG0671	phosphoesterase, PA-phosphatase related
B4071_RS17760	COG4479	Belongs to the UPF0346 family
B4071_RS17770	COG1509	lysine 2,3-aminomutase activity
B4071_RS17775	COG0456	acetyltransferase
B4071_RS17780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4071_RS17785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4071_RS17790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4071_RS17795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4071_RS17810	COG0456	acetyltransferase
B4071_RS17815	COG0463	Glycosyl transferase, family 2
B4071_RS17830	COG4641	Protein conserved in bacteria
B4071_RS17835	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B4071_RS17840	COG1086	Polysaccharide biosynthesis protein
B4071_RS17850	COG3331	DNA recombination
B4071_RS17900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4071_RS17930	COG0756	dUTP diphosphatase activity
B4071_RS17940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS17945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4071_RS17955	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4071_RS17965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4071_RS17975	COG1372	Participates in initiation and elongation during chromosome replication
B4071_RS17975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4071_RS17980	COG1780	Probably involved in ribonucleotide reductase function
B4071_RS18045	COG0270	DNA (cytosine-5-)-methyltransferase activity
B4071_RS18060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4071_RS18085	COG3584	3D domain protein
B4071_RS18095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4071_RS18160	COG1793	dna ligase
B4071_RS18165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B4071_RS18170	COG2199	diguanylate cyclase activity
B4071_RS18170	COG2203	Gaf domain
B4071_RS18175	COG2211	Major facilitator Superfamily
B4071_RS18180	COG3507	Belongs to the glycosyl hydrolase 43 family
B4071_RS18185	COG1940	carbohydrate kinase activity
B4071_RS18190	COG2115	Belongs to the xylose isomerase family
B4071_RS18195	COG1070	Carbohydrate kinase
B4071_RS18200	COG0596	Alpha beta hydrolase
B4071_RS18205	COG1902	pentaerythritol trinitrate reductase activity
B4071_RS18210	COG4187	Peptidase family M20/M25/M40
B4071_RS18245	COG1346	cytolysis
B4071_RS18250	COG1380	Effector of murein hydrolase LrgA
B4071_RS18255	COG1846	Transcriptional regulator
B4071_RS18265	COG1876	peptidase activity
B4071_RS18285	COG0454	-acetyltransferase
B4071_RS18290	COG2153	protein acetylation
B4071_RS18300	COG1666	GTP binding
B4071_RS18305	COG2996	Protein conserved in bacteria
B4071_RS18325	COG1695	Transcriptional regulator
B4071_RS18340	COG3227	Zinc metalloprotease (Elastase)
B4071_RS18345	COG1307	EDD domain protein, DegV family
B4071_RS18350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4071_RS18370	COG0561	phosphatase activity
B4071_RS18375	COG1073	alpha beta
B4071_RS18380	COG2151	metal-sulfur cluster biosynthetic enzyme
B4071_RS18390	COG0277	FAD linked oxidase domain protein
B4071_RS18395	COG2271	Major facilitator Superfamily
B4071_RS18400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B4071_RS18405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B4071_RS18415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4071_RS18420	COG0505	Belongs to the CarA family
B4071_RS18425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4071_RS18430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4071_RS18445	COG2267	carboxylic ester hydrolase activity
B4071_RS18455	COG1744	ABC transporter substrate-binding protein PnrA-like
B4071_RS18470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4071_RS18475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4071_RS18480	COG5504	Zn-dependent protease
B4071_RS18485	COG0444	Belongs to the ABC transporter superfamily
B4071_RS18490	COG4608	Belongs to the ABC transporter superfamily
B4071_RS18500	COG0601	transmembrane transport
B4071_RS18505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4071_RS18515	COG0180	Tryptophanyl-tRNA synthetase
B4071_RS18520	COG4166	transmembrane transport
B4071_RS18525	COG0601	transmembrane transport
B4071_RS18530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4071_RS18535	COG0444	Belongs to the ABC transporter superfamily
B4071_RS18540	COG4608	Belongs to the ABC transporter superfamily
B4071_RS18545	COG2814	Major facilitator Superfamily
B4071_RS18550	COG0456	acetyltransferase
B4071_RS18555	COG1393	Belongs to the ArsC family
B4071_RS18560	COG0861	Integral membrane protein TerC family
B4071_RS18565	COG4862	establishment of competence for transformation
B4071_RS18570	COG4469	Competence protein
B4071_RS18575	COG1164	Oligoendopeptidase f
B4071_RS18590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4071_RS18595	COG2346	COG2346, Truncated hemoglobins
B4071_RS18600	COG0741	lytic transglycosylase activity
B4071_RS18605	COG4116	CYTH
B4071_RS18615	COG2357	RelA SpoT domain protein
B4071_RS18620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4071_RS18625	COG0564	pseudouridine synthase activity
B4071_RS18630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4071_RS18635	COG0569	domain protein
B4071_RS18635	COG0475	glutathione-regulated potassium exporter activity
B4071_RS18640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B4071_RS18645	COG0352	thiamine-phosphate diphosphorylase activity
B4071_RS18650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4071_RS18655	COG2104	thiamine diphosphate biosynthetic process
B4071_RS18660	COG2022	thiamine diphosphate biosynthetic process
B4071_RS18665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4071_RS18670	COG0351	phosphomethylpyrimidine kinase
B4071_RS18675	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B4071_RS18735	COG0210	DNA helicase
B4071_RS18745	COG2153	protein acetylation
B4071_RS18750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4071_RS18755	COG2382	esterase
B4071_RS18760	COG0626	cystathionine gamma-synthase activity
B4071_RS18765	COG0626	cystathionine gamma-synthase activity
B4071_RS18770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4071_RS18775	COG5505	Protein of unknown function (DUF819)
B4071_RS18800	COG5444	nuclease activity
B4071_RS18815	COG2801	Transposase and inactivated derivatives
B4071_RS18845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B4071_RS18855	COG1063	alcohol dehydrogenase
B4071_RS18875	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
B4071_RS18880	COG0456	acetyltransferase
B4071_RS18885	COG0457	Tetratricopeptide repeat
B4071_RS18895	COG0010	Belongs to the arginase family
B4071_RS18900	COG0833	amino acid
B4071_RS18905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4071_RS18910	COG3829	transcription factor binding
B4071_RS18920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4071_RS18925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4071_RS18930	COG4853	Protein conserved in bacteria
B4071_RS18935	COG4863	YycH protein
B4071_RS18940	COG5002	protein histidine kinase activity
B4071_RS18945	COG0745	RESPONSE REGULATOR receiver
B4071_RS18980	COG0305	Participates in initiation and elongation during chromosome replication
B4071_RS19000	COG3093	addiction module antidote protein HigA
B4071_RS19005	COG2807	transmembrane transport
B4071_RS19010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B4071_RS19015	COG0359	binds to the 23S rRNA
B4071_RS19020	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B4071_RS19025	COG4241	membrane
B4071_RS19040	COG1733	regulation of RNA biosynthetic process
B4071_RS19045	COG1227	inorganic diphosphatase activity
B4071_RS19060	COG2271	Major facilitator Superfamily
B4071_RS19065	COG4978	Transcriptional regulator
B4071_RS19065	COG0789	Transcriptional regulator
B4071_RS19075	COG4319	ketosteroid isomerase
B4071_RS19080	COG1357	PFAM Pentapeptide repeats (8 copies)
B4071_RS19085	COG2814	Major facilitator Superfamily
B4071_RS19090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4071_RS19095	COG1846	Transcriptional regulator
B4071_RS19100	COG2153	protein acetylation
B4071_RS19105	COG2364	Membrane
B4071_RS19110	COG0456	acetyltransferase
B4071_RS19115	COG2315	Protein conserved in bacteria
B4071_RS19120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4071_RS19125	COG2814	Major facilitator Superfamily
B4071_RS19130	COG1331	Highly conserved protein containing a thioredoxin domain
B4071_RS19135	COG1266	CAAX protease self-immunity
B4071_RS19140	COG2814	Major facilitator Superfamily
B4071_RS19140	COG0477	Major facilitator Superfamily
B4071_RS19145	COG0110	maltose O-acetyltransferase activity
B4071_RS19150	COG0346	lactoylglutathione lyase activity
B4071_RS19155	COG1609	Transcriptional regulator
B4071_RS19160	COG0708	Exodeoxyribonuclease III
B4071_RS19165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B4071_RS19170	COG0629	single-stranded DNA binding
B4071_RS19175	COG0360	Binds together with S18 to 16S ribosomal RNA
B4071_RS19180	COG0012	GTP binding
B4071_RS19185	COG0243	molybdopterin cofactor binding
B4071_RS19190	COG4481	Protein conserved in bacteria
B4071_RS19195	COG3949	Membrane
B4071_RS19205	COG1475	DNA binding
B4071_RS19210	COG1192	Involved in chromosome partitioning
B4071_RS19220	COG1475	DNA binding
B4071_RS19225	COG0357	Ribosomal RNA small subunit methyltransferase G
B4071_RS19230	COG0445	tRNA wobble uridine modification
B4071_RS19235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B4071_RS19240	COG1847	R3H domain protein
B4071_RS19245	COG0706	membrane insertase activity
B4071_RS19250	COG0594	ribonuclease P activity
B4071_RS19260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4071_RS19265	COG0592	DNA-directed DNA polymerase activity
B4071_RS19270	COG2501	S4 domain
B4071_RS19275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4071_RS19285	COG0187	DNA topoisomerase II activity
B4071_RS19290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4071_RS19315	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B4071_RS19320	COG0802	atpase or kinase
B4071_RS19325	COG1214	PFAM Peptidase M22, glycoprotease
B4071_RS19330	COG0456	acetyltransferase
B4071_RS19335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B4071_RS19340	COG0488	(ABC) transporter
B4071_RS19345	COG0315	cyclic pyranopterin monophosphate synthase activity
B4071_RS19350	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B4071_RS19355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4071_RS19360	COG0805	protein transport
B4071_RS19370	COG1266	CAAX protease self-immunity
B4071_RS19380	COG0459	protein refolding
B4071_RS19395	COG5444	nuclease activity
B4071_RS19405	COG2322	membrane
B4071_RS19425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4071_RS19430	COG0457	Tetratricopeptide repeat
B4071_RS19435	COG1063	alcohol dehydrogenase
B4071_RS19440	COG2211	Major facilitator Superfamily
B4071_RS19445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4071_RS19450	COG1842	Phage shock protein A
B4071_RS19455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4071_RS19460	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B4071_RS19465	COG4260	virion core protein, lumpy skin disease virus
B4071_RS19475	COG2814	Major facilitator Superfamily
B4071_RS19480	COG1063	alcohol dehydrogenase
B4071_RS19485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B4071_RS19490	COG0823	Involved in the tonB-independent uptake of proteins
B4071_RS19495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4071_RS19525	COG3091	SprT-like family
B4071_RS19535	COG2183	response to ionizing radiation
B4071_RS19540	COG2208	phosphoserine phosphatase activity
B4071_RS19545	COG1191	sigma factor activity
B4071_RS19550	COG2172	sigma factor antagonist activity
B4071_RS19555	COG1366	Belongs to the anti-sigma-factor antagonist family
B4071_RS19560	COG2208	phosphoserine phosphatase activity
B4071_RS19565	COG2172	sigma factor antagonist activity
B4071_RS19570	COG1366	Belongs to the anti-sigma-factor antagonist family
B4071_RS19575	COG1366	Belongs to the anti-sigma-factor antagonist family
B4071_RS19580	COG2337	Toxic component of a toxin-antitoxin (TA) module
B4071_RS19585	COG0864	Transcriptional regulator
B4071_RS19590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4071_RS19595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B4071_RS19600	COG0736	holo-[acyl-carrier-protein] synthase activity
B4071_RS19605	COG0705	Rhomboid family
B4071_RS19610	COG3428	Bacterial PH domain
B4071_RS19615	COG3402	PFAM membrane-flanked domain
B4071_RS19620	COG0513	Belongs to the DEAD box helicase family
B4071_RS19625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4071_RS19630	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4071_RS19635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS19640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4071_RS19655	COG1960	acyl-CoA dehydrogenase activity
B4071_RS19665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4071_RS19670	COG1131	(ABC) transporter
B4071_RS19680	COG0628	permease
B4071_RS19685	COG1301	dicarboxylic acid transport
B4071_RS19690	COG4565	transcriptional regulatory protein
B4071_RS19695	COG3290	protein histidine kinase activity
B4071_RS19700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B4071_RS19710	COG2329	Antibiotic biosynthesis monooxygenase
B4071_RS19715	COG0662	Cupin 2, conserved barrel domain protein
B4071_RS19720	COG3729	General stress protein
B4071_RS19725	COG2217	Heavy metal translocating P-type atpase
B4071_RS19730	COG4876	unkown
B4071_RS19735	COG2261	transglycosylase associated protein
B4071_RS19740	COG1914	H( )-stimulated, divalent metal cation uptake system
B4071_RS19755	COG0028	Belongs to the TPP enzyme family
B4071_RS19760	COG0494	nUDIX hydrolase
B4071_RS19765	COG0531	amino acid
B4071_RS19775	COG1215	transferase activity, transferring glycosyl groups
B4071_RS19790	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B4071_RS19795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4071_RS19795	COG0551	DNA topoisomerase type I activity
B4071_RS19800	COG1522	sequence-specific DNA binding
B4071_RS19805	COG2814	Major facilitator Superfamily
B4071_RS19815	COG3871	stress protein (general stress protein 26)
B4071_RS19820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4071_RS19825	COG1917	Cupin 2, conserved barrel domain protein
B4071_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS19835	COG2226	methyltransferase
B4071_RS19840	COG0318	PFAM AMP-dependent synthetase and ligase
B4071_RS19845	COG3711	transcriptional antiterminator
B4071_RS19850	COG4989	oxidoreductase activity
B4071_RS19855	COG0768	penicillin binding
B4071_RS19870	COG2755	lipolytic protein G-D-S-L family
B4071_RS19875	COG1414	Transcriptional regulator
B4071_RS19880	COG1984	allophanate hydrolase subunit 2
B4071_RS19885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4071_RS19890	COG4336	lyase activity
B4071_RS19895	COG1914	H( )-stimulated, divalent metal cation uptake system
B4071_RS19900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B4071_RS19905	COG0561	phosphatase activity
B4071_RS19950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4071_RS19955	COG0412	Dienelactone hydrolase
B4071_RS19965	COG0681	Belongs to the peptidase S26 family
B4071_RS19970	COG0473	3-isopropylmalate dehydrogenase activity
B4071_RS19975	COG0246	Mannitol dehydrogenase
B4071_RS19980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4071_RS19985	COG2213	PTS system mannitol-specific
B4071_RS19995	COG1349	DNA-binding transcription factor activity
B4071_RS20000	COG2372	response to copper ion
B4071_RS20000	COG1276	copper resistance
B4071_RS20005	COG4549	nuclear export factor GLE1
B4071_RS20010	COG1028	Short-chain dehydrogenase reductase Sdr
B4071_RS20015	COG4975	Glucose uptake
B4071_RS20020	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS20025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B4071_RS20030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4071_RS20035	COG0640	Transcriptional regulator
B4071_RS20040	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B4071_RS20045	COG0778	Nitroreductase
B4071_RS20050	COG1309	transcriptional regulator
B4071_RS20055	COG2814	Major facilitator Superfamily
B4071_RS20060	COG4607	ABC-type enterochelin transport system periplasmic component
B4071_RS20065	COG4604	ABC transporter, ATP-binding protein
B4071_RS20070	COG4605	iron ion homeostasis
B4071_RS20075	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4071_RS20080	COG0527	aspartate kinase activity
B4071_RS20100	COG0457	Tetratricopeptide repeat
B4071_RS20105	COG5002	protein histidine kinase activity
B4071_RS20105	COG3850	Histidine kinase
B4071_RS20110	COG0745	RESPONSE REGULATOR receiver
B4071_RS20115	COG0577	efflux transmembrane transporter activity
B4071_RS20120	COG1136	(ABC) transporter
B4071_RS20125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4071_RS20135	COG0697	spore germination
B4071_RS20145	COG5434	Belongs to the glycosyl hydrolase 28 family
B4071_RS20150	COG3104	oligopeptide transport
B4071_RS20155	COG0596	Alpha beta hydrolase
B4071_RS20170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B4071_RS20175	COG0163	prenyltransferase activity
B4071_RS20180	COG0583	DNA-binding transcription factor activity
B4071_RS20185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4071_RS20190	COG0765	amino acid transport
B4071_RS20195	COG1126	abc transporter atp-binding protein
B4071_RS20200	COG2364	Membrane
B4071_RS20215	COG0697	spore germination
B4071_RS20225	COG2814	Major facilitator Superfamily
B4071_RS20230	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B4071_RS20235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4071_RS20240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4071_RS20245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4071_RS20255	COG1733	regulation of RNA biosynthetic process
B4071_RS20260	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B4071_RS20265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B4071_RS20275	COG3209	COG3209 Rhs family protein
B4071_RS20295	COG1714	RDD family
B4071_RS20305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4071_RS20310	COG0765	amino acid transport
B4071_RS20325	COG1376	ErfK ybiS ycfS ynhG family protein
B4071_RS20330	COG1469	GTP cyclohydrolase I activity
B4071_RS20335	COG2223	nitrite transmembrane transporter activity
B4071_RS20345	COG0243	molybdopterin cofactor binding
B4071_RS20350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4071_RS20355	COG2146	nitrite reductase [NAD(P)H] activity
B4071_RS20360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4071_RS20360	COG1587	Uroporphyrinogen-III synthase
B4071_RS20365	COG0492	ferredoxin-NADP+ reductase activity
B4071_RS20370	COG2267	carboxylic ester hydrolase activity
B4071_RS20375	COG0701	Predicted permease
B4071_RS20380	COG3689	TIGRFAM TIGR03943 family protein
B4071_RS20385	COG2508	Transcriptional regulator
B4071_RS20390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4071_RS20395	COG1012	belongs to the aldehyde dehydrogenase family
B4071_RS20400	COG0506	proline dehydrogenase activity
B4071_RS20405	COG3541	Predicted nucleotidyltransferase
B4071_RS20410	COG3458	cephalosporin-C deacetylase activity
B4071_RS20415	COG0583	DNA-binding transcription factor activity
B4071_RS20420	COG2226	methyltransferase
B4071_RS20425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B4071_RS20435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4071_RS20450	COG3403	YqcI/YcgG family
B4071_RS20455	COG1280	lysine exporter protein (LysE YggA)
B4071_RS20460	COG1846	Transcriptional regulator
B4071_RS20465	COG2814	Major facilitator Superfamily
B4071_RS20470	COG1620	l-lactate permease
B4071_RS20475	COG0039	L-malate dehydrogenase activity
B4071_RS20490	COG4124	Belongs to the glycosyl hydrolase 26 family
B4071_RS20495	COG1482	cell wall glycoprotein biosynthetic process
B4071_RS20500	COG1940	carbohydrate kinase activity
B4071_RS20505	COG2188	Transcriptional regulator
B4071_RS20510	COG2723	6-phospho-beta-galactosidase activity
B4071_RS20515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4071_RS20520	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4071_RS20525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4071_RS20530	COG2814	Major facilitator Superfamily
B4071_RS20535	COG1388	LysM domain
B4071_RS20540	COG1078	dGTPase activity
B4071_RS20545	COG0454	-acetyltransferase
B4071_RS20555	COG5646	InterPro IPR014922
B4071_RS20560	COG1785	Belongs to the alkaline phosphatase family
B4071_RS20570	COG1819	glycosyl
B4071_RS20575	COG3858	chitin binding
B4071_RS20575	COG1388	LysM domain
B4071_RS20580	COG1802	Transcriptional regulator
B4071_RS20585	COG0730	response to heat
B4071_RS20590	COG2814	Major facilitator Superfamily
B4071_RS20595	COG1846	Transcriptional regulator
B4071_RS20600	COG0778	Nitroreductase
B4071_RS20605	COG1033	growth of symbiont in host cell
B4071_RS20605	COG2409	Drug exporters of the RND superfamily
B4071_RS20610	COG1846	Transcriptional regulator
B4071_RS20615	COG2318	DinB family
B4071_RS20620	COG1113	amino acid transport
B4071_RS20630	COG0456	acetyltransferase
B4071_RS20640	COG1309	transcriptional regulator
B4071_RS20655	COG0071	Belongs to the small heat shock protein (HSP20) family
B4071_RS20660	COG2323	membrane
B4071_RS20685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS20690	COG2259	Doxx family
B4071_RS20695	COG0346	lactoylglutathione lyase activity
B4071_RS20700	COG0778	Nitroreductase
B4071_RS20705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4071_RS20725	COG0789	Transcriptional regulator
B4071_RS20725	COG4978	Transcriptional regulator
B4071_RS20730	COG1811	Na channel or pump
B4071_RS20735	COG2409	Drug exporters of the RND superfamily
B4071_RS20740	COG2197	response regulator
B4071_RS20745	COG4585	Histidine kinase
B4071_RS20760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4071_RS20765	COG0640	Transcriptional regulator
B4071_RS20770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4071_RS20775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4071_RS20780	COG0697	spore germination
B4071_RS20785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4071_RS20790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4071_RS20795	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4071_RS20800	COG0640	Transcriptional regulator
B4071_RS20805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4071_RS20810	COG1733	regulation of RNA biosynthetic process
B4071_RS20815	COG3545	Serine hydrolase
B4071_RS20820	COG2030	dehydratase
B4071_RS20825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4071_RS20830	COG0697	spore germination
B4071_RS20835	COG1309	transcriptional regulator
B4071_RS20840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4071_RS20855	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B4071_RS20860	COG0477	Major facilitator Superfamily
B4071_RS20865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4071_RS20870	COG2207	Transcriptional regulator
B4071_RS20870	COG3708	Transcriptional regulator
B4071_RS20880	COG0697	spore germination
B4071_RS20885	COG1917	Cupin 2, conserved barrel domain protein
B4071_RS20885	COG2207	Transcriptional regulator
B4071_RS20890	COG0697	spore germination
B4071_RS20895	COG1329	Transcriptional regulator
B4071_RS20900	COG1278	Cold shock
B4071_RS20910	COG3239	Fatty acid desaturase
B4071_RS20920	COG1476	TRANSCRIPTIONal
B4071_RS21060	COG3655	Transcriptional regulator
B4071_RS21075	COG0582	viral genome integration into host DNA
B4071_RS21245	COG0776	regulation of translation
B4071_RS21280	COG4373	Mu-like prophage FluMu protein gp28
B4071_RS21365	COG0584	glycerophosphoryl diester phosphodiesterase
B4071_RS21380	COG0582	viral genome integration into host DNA
B4071_RS21390	COG0739	heme binding
B4071_RS21390	COG0741	lytic transglycosylase activity
B4071_RS21390	COG1196	nuclear chromosome segregation
B4071_RS21400	COG2433	Pfam Transposase IS66
B4071_RS21410	COG5434	Belongs to the glycosyl hydrolase 28 family
B4071_RS21420	COG3328	transposase activity
B4071_RS21550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B4071_RS21555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4071_RS21560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4071_RS21565	COG0297	glycogen (starch) synthase activity
B4071_RS21570	COG0058	SHG alpha-glucan phosphorylase activity
B4071_RS21575	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B4071_RS21580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4071_RS21585	COG0438	transferase activity, transferring glycosyl groups
B4071_RS21590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4071_RS21600	COG0438	transferase activity, transferring glycosyl groups
B4071_RS21605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4071_RS21610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4071_RS21615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4071_RS21620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4071_RS21625	COG1169	isochorismate synthase
B4071_RS21630	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B4071_RS21635	COG0596	Alpha beta hydrolase
B4071_RS21640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B4071_RS21645	COG0318	PFAM AMP-dependent synthetase and ligase
B4071_RS21650	COG4948	Mandelate Racemase Muconate Lactonizing
B4071_RS21655	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4071_RS21660	COG1121	(ABC) transporter
B4071_RS21670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4071_RS21680	COG1294	oxidase, subunit
B4071_RS21685	COG1271	oxidase subunit
B4071_RS21690	COG0254	rRNA binding
B4071_RS21695	COG0288	reversible hydration of carbon dioxide
B4071_RS21700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B4071_RS21705	COG1854	S-ribosylhomocysteine lyase activity
B4071_RS21720	COG0783	Belongs to the Dps family
B4071_RS21725	COG4824	toxin secretion phage lysis holin
B4071_RS21730	COG0494	nUDIX hydrolase
B4071_RS21735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4071_RS21740	COG1116	anion transmembrane transporter activity
B4071_RS21745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4071_RS21750	COG1506	peptidase
B4071_RS21760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B4071_RS21765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4071_RS21770	COG0367	asparagine synthase
B4071_RS21775	COG1113	amino acid transport
B4071_RS21780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B4071_RS21785	COG2267	carboxylic ester hydrolase activity
B4071_RS21795	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4071_RS21800	COG1242	4 iron, 4 sulfur cluster binding
B4071_RS21815	COG1725	Transcriptional regulator
B4071_RS21820	COG1131	(ABC) transporter
B4071_RS21835	COG1136	(ABC) transporter
B4071_RS21840	COG0577	efflux transmembrane transporter activity
B4071_RS21845	COG0745	RESPONSE REGULATOR receiver
B4071_RS21850	COG2205	protein histidine kinase activity
B4071_RS21855	COG1136	(ABC) transporter
B4071_RS21860	COG0577	efflux transmembrane transporter activity
B4071_RS21865	COG2433	Pfam Transposase IS66
B4071_RS21870	COG2814	Major facilitator Superfamily
B4071_RS21875	COG2202	Pas domain
B4071_RS21875	COG1366	Belongs to the anti-sigma-factor antagonist family
B4071_RS21885	COG0495	leucyl-tRNA aminoacylation
B4071_RS21890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4071_RS21895	COG1486	melibiose metabolic process
B4071_RS21900	COG0395	ABC-type sugar transport system, permease component
B4071_RS21905	COG1175	transmembrane transport
B4071_RS21910	COG1653	transport
B4071_RS21915	COG1609	Transcriptional regulator
B4071_RS21920	COG1073	alpha beta
B4071_RS21925	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B4071_RS21930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4071_RS21935	COG0156	8-amino-7-oxononanoate synthase activity
B4071_RS21945	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B4071_RS21950	COG2124	cytochrome p450
B4071_RS21955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4071_RS21960	COG0395	ABC-type sugar transport system, permease component
B4071_RS21980	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B4071_RS21985	COG1653	transport
B4071_RS21995	COG5578	integral membrane protein
B4071_RS22005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4071_RS22010	COG2081	HI0933 family
B4071_RS22015	COG2244	polysaccharide biosynthetic process
B4071_RS22020	COG1187	pseudouridine synthase activity
B4071_RS22025	COG1349	DNA-binding transcription factor activity
B4071_RS22030	COG1131	(ABC) transporter
B4071_RS22035	COG4473	ABC transporter
B4071_RS22040	COG2252	PERMEase
B4071_RS22045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4071_RS22050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4071_RS22055	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4071_RS22065	COG1597	lipid kinase activity
B4071_RS22070	COG1523	belongs to the glycosyl hydrolase 13 family
B4071_RS22075	COG0510	thiamine kinase activity
B4071_RS22085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B4071_RS22090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4071_RS22095	COG0281	malic enzyme
B4071_RS22100	COG5584	Small secreted protein
B4071_RS22105	COG1363	Peptidase, m42
B4071_RS22115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4071_RS22120	COG4848	Belongs to the UPF0354 family
B4071_RS22125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4071_RS22130	COG1674	ftsk spoiiie
B4071_RS22135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4071_RS22140	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4071_RS22145	COG4980	gas vesicle protein
B4071_RS22150	COG3118	belongs to the thioredoxin family
B4071_RS22155	COG1605	Chorismate mutase
B4071_RS22155	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4071_RS22160	COG1609	Transcriptional regulator
B4071_RS22165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4071_RS22170	COG1360	Flagellar Motor Protein
B4071_RS22175	COG0123	including yeast histone deacetylase and acetoin utilization protein
B4071_RS22180	COG0517	IMP dehydrogenase activity
B4071_RS22185	COG0454	-acetyltransferase
B4071_RS22190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4071_RS22195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4071_RS22235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4071_RS22290	COG0457	Tetratricopeptide repeat