locus-tag	class	description
B4072_RS00015	COG2814	Major facilitator Superfamily
B4072_RS00030	COG2137	regulation of response to DNA damage stimulus
B4072_RS00035	COG1090	epimerase
B4072_RS00050	COG0778	Nitroreductase
B4072_RS00055	COG0384	phenazine biosynthesis protein PhzF
B4072_RS00060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS00065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS00070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4072_RS00075	COG0392	lysyltransferase activity
B4072_RS00075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B4072_RS00080	COG1846	Transcriptional regulator
B4072_RS00085	COG2814	Major facilitator Superfamily
B4072_RS00090	COG2318	DinB family
B4072_RS00095	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B4072_RS00100	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B4072_RS00105	COG1695	Transcriptional regulator
B4072_RS00115	COG0842	Transport permease protein
B4072_RS00120	COG1511	domain protein
B4072_RS00120	COG0842	Transport permease protein
B4072_RS00125	COG1131	(ABC) transporter
B4072_RS00130	COG2197	response regulator
B4072_RS00135	COG4585	Histidine kinase
B4072_RS00140	COG0673	inositol 2-dehydrogenase activity
B4072_RS00145	COG1082	Xylose isomerase domain protein TIM barrel
B4072_RS00150	COG2814	Major facilitator Superfamily
B4072_RS00155	COG1917	Cupin 2, conserved barrel domain protein
B4072_RS00155	COG4977	sequence-specific DNA binding
B4072_RS00160	COG2514	catechol 2,3-dioxygenase activity
B4072_RS00165	COG2259	Doxx family
B4072_RS00170	COG1132	(ABC) transporter
B4072_RS00175	COG1132	(ABC) transporter
B4072_RS00180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4072_RS00180	COG1263	PTS System
B4072_RS00185	COG1737	Transcriptional regulator
B4072_RS00190	COG1486	melibiose metabolic process
B4072_RS00195	COG4842	Belongs to the WXG100 family
B4072_RS00215	COG1742	UPF0060 membrane protein
B4072_RS00225	COG3284	Transcriptional regulator
B4072_RS00230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4072_RS00235	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4072_RS00240	COG0022	dehydrogenase e1 component
B4072_RS00245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4072_RS00255	COG4637	Psort location Cytoplasmic, score
B4072_RS00260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4072_RS00270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4072_RS00275	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4072_RS00280	COG0598	Magnesium transport protein CorA
B4072_RS00290	COG0726	polysaccharide deacetylase
B4072_RS00300	COG0535	radical SAM domain protein
B4072_RS00305	COG0668	transmembrane transport
B4072_RS00315	COG0387	Pfam Sodium calcium exchanger
B4072_RS00325	COG0477	Major facilitator Superfamily
B4072_RS00335	COG1295	ribonuclease BN
B4072_RS00340	COG4980	gas vesicle protein
B4072_RS00345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4072_RS00350	COG4840	Belongs to the UPF0435 family
B4072_RS00355	COG2814	Major facilitator Superfamily
B4072_RS00360	COG0693	protein deglycase activity
B4072_RS00365	COG0737	Belongs to the 5'-nucleotidase family
B4072_RS00370	COG0778	Nitroreductase
B4072_RS00375	COG2188	Transcriptional regulator
B4072_RS00380	COG0366	Alpha amylase catalytic
B4072_RS00385	COG1263	PTS System
B4072_RS00385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4072_RS00390	COG0697	spore germination
B4072_RS00400	COG1368	sulfuric ester hydrolase activity
B4072_RS00405	COG1263	PTS System
B4072_RS00405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4072_RS00410	COG0024	Methionine aminopeptidase
B4072_RS00430	COG2258	MOSC domain
B4072_RS00435	COG1254	Belongs to the acylphosphatase family
B4072_RS00440	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B4072_RS00445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4072_RS00450	COG2851	Citrate transporter
B4072_RS00460	COG3181	Tripartite tricarboxylate transporter family receptor
B4072_RS00465	COG4565	transcriptional regulatory protein
B4072_RS00470	COG3290	protein histidine kinase activity
B4072_RS00475	COG0471	metal ion transport
B4072_RS00480	COG3866	Pectate lyase
B4072_RS00495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4072_RS00500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS00505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS00510	COG1120	ATPase activity
B4072_RS00515	COG4373	Mu-like prophage FluMu protein gp28
B4072_RS00615	COG0582	viral genome integration into host DNA
B4072_RS00640	COG0739	heme binding
B4072_RS00640	COG0741	lytic transglycosylase activity
B4072_RS00640	COG1196	nuclear chromosome segregation
B4072_RS00650	COG2433	Pfam Transposase IS66
B4072_RS00660	COG4632	Exopolysaccharide biosynthesis protein
B4072_RS00660	COG5434	Belongs to the glycosyl hydrolase 28 family
B4072_RS00665	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4072_RS00680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4072_RS00685	COG0463	Glycosyl transferase, family 2
B4072_RS00690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS00695	COG3271	cysteine-type peptidase activity
B4072_RS00695	COG2274	protein secretion by the type I secretion system
B4072_RS00745	COG5444	nuclease activity
B4072_RS00750	COG4282	regulation of fungal-type cell wall biogenesis
B4072_RS00760	COG1525	nuclease
B4072_RS00775	COG0464	growth
B4072_RS00780	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4072_RS00785	COG4112	unkown
B4072_RS00790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4072_RS00795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4072_RS00800	COG1780	Probably involved in ribonucleotide reductase function
B4072_RS00815	COG1923	regulation of RNA biosynthetic process
B4072_RS00820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B4072_RS00835	COG2076	Multidrug Resistance protein
B4072_RS00840	COG2076	Multidrug Resistance protein
B4072_RS00845	COG1764	response to oxidative stress
B4072_RS00850	COG4195	phage-related replication protein
B4072_RS00860	COG1404	Belongs to the peptidase S8 family
B4072_RS00865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4072_RS00875	COG3226	Transcriptional regulator
B4072_RS00895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B4072_RS00900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B4072_RS00910	COG4550	Control of competence regulator ComK, YlbF/YmcA
B4072_RS00915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4072_RS00920	COG0156	8-amino-7-oxononanoate synthase activity
B4072_RS00925	COG1063	alcohol dehydrogenase
B4072_RS00930	COG2359	stage V sporulation protein S
B4072_RS00935	COG1692	metallophosphoesterase
B4072_RS00940	COG1418	mRNA catabolic process
B4072_RS00945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4072_RS00950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B4072_RS00955	COG1058	Belongs to the CinA family
B4072_RS00955	COG1546	Belongs to the CinA family
B4072_RS00960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4072_RS00965	COG1426	Protein conserved in bacteria
B4072_RS00980	COG0300	oxidoreductase activity
B4072_RS00985	COG0612	Peptidase, M16
B4072_RS00990	COG0612	Peptidase, M16
B4072_RS00995	COG2814	Major facilitator Superfamily
B4072_RS01000	COG2188	Transcriptional regulator
B4072_RS01005	COG1674	ftsk spoiiie
B4072_RS01005	COG4980	gas vesicle protein
B4072_RS01015	COG0740	serine-type endopeptidase activity
B4072_RS01020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4072_RS01025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4072_RS01030	COG0527	aspartate kinase activity
B4072_RS01035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4072_RS01040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4072_RS01045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4072_RS01055	COG1873	PFAM PRC-barrel domain
B4072_RS01060	COG0612	Peptidase, M16
B4072_RS01065	COG0726	polysaccharide deacetylase
B4072_RS01070	COG1185	polyribonucleotide nucleotidyltransferase activity
B4072_RS01075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4072_RS01080	COG0196	riboflavin kinase activity
B4072_RS01085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B4072_RS01090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B4072_RS01095	COG1550	Protein conserved in bacteria
B4072_RS01100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B4072_RS01105	COG1358	cellular component organization or biogenesis
B4072_RS01110	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4072_RS01115	COG0195	Participates in both transcription termination and antitermination
B4072_RS01120	COG0779	Required for maturation of 30S ribosomal subunits
B4072_RS01125	COG2176	DNA-directed DNA polymerase activity
B4072_RS01130	COG0442	prolyl-tRNA aminoacylation
B4072_RS01135	COG0750	zinc metalloprotease
B4072_RS01140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B4072_RS01145	COG4589	Belongs to the CDS family
B4072_RS01150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B4072_RS01155	COG0233	cytoplasmic translational termination
B4072_RS01160	COG0528	UMP kinase activity
B4072_RS01165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B4072_RS01170	COG0052	Belongs to the universal ribosomal protein uS2 family
B4072_RS01180	COG1191	sigma factor activity
B4072_RS01185	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B4072_RS01190	COG1776	CheC inhibitor of MCP methylation
B4072_RS01195	COG0835	chemotaxis
B4072_RS01200	COG2198	Histidine kinase
B4072_RS01200	COG0643	Histidine kinase
B4072_RS01205	COG2201	protein-glutamate methylesterase activity
B4072_RS01210	COG0455	bacterial-type flagellum organization
B4072_RS01215	COG1419	protein localization to endoplasmic reticulum
B4072_RS01220	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4072_RS01225	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4072_RS01230	COG1684	flagellar biosynthetic protein fliR
B4072_RS01235	COG1987	bacterial-type flagellum assembly
B4072_RS01240	COG1338	Plays a role in the flagellum-specific transport system
B4072_RS01245	COG3190	flagellar
B4072_RS01250	COG2201	protein-glutamate methylesterase activity
B4072_RS01255	COG1776	CheC inhibitor of MCP methylation
B4072_RS01255	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4072_RS01260	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4072_RS01265	COG1580	Controls the rotational direction of flagella during chemotaxis
B4072_RS01270	COG1582	Flagellar protein (FlbD)
B4072_RS01275	COG4786	Flagellar basal body rod
B4072_RS01280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B4072_RS01285	COG3144	bacterial-type flagellum assembly
B4072_RS01290	COG3334	PFAM MgtE intracellular
B4072_RS01295	COG2882	bacterial-type flagellum organization
B4072_RS01300	COG1157	protein secretion by the type III secretion system
B4072_RS01305	COG1317	bacterial-type flagellum organization
B4072_RS01310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4072_RS01315	COG1766	The M ring may be actively involved in energy transduction
B4072_RS01320	COG1677	Flagellar hook-basal body complex protein FliE
B4072_RS01325	COG1558	bacterial-type flagellum-dependent cell motility
B4072_RS01330	COG1815	bacterial-type flagellum-dependent cell motility
B4072_RS01335	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B4072_RS01340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B4072_RS01345	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B4072_RS01350	COG4974	Belongs to the 'phage' integrase family
B4072_RS01355	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B4072_RS01360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4072_RS01365	COG0758	DNA mediated transformation
B4072_RS01370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4072_RS01375	COG0045	succinate-CoA ligase (ADP-forming) activity
B4072_RS01380	COG2257	FlhB HrpN YscU SpaS Family
B4072_RS01390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4072_RS01395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4072_RS01400	COG0335	large ribosomal subunit rRNA binding
B4072_RS01405	COG0336	Belongs to the RNA methyltransferase TrmD family
B4072_RS01410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B4072_RS01420	COG1837	Belongs to the UPF0109 family
B4072_RS01425	COG0228	four-way junction DNA binding
B4072_RS01430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4072_RS01435	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B4072_RS01445	COG0552	protein localization to endoplasmic reticulum
B4072_RS01450	COG1196	nuclear chromosome segregation
B4072_RS01455	COG0571	ribonuclease III activity
B4072_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS01470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4072_RS01475	COG0416	fatty acid biosynthetic process
B4072_RS01480	COG1349	DNA-binding transcription factor activity
B4072_RS01480	COG2050	protein possibly involved in aromatic compounds catabolism
B4072_RS01485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4072_RS01490	COG1760	l-serine dehydratase
B4072_RS01495	COG1760	l-serine dehydratase
B4072_RS01500	COG1461	Dihydroxyacetone kinase
B4072_RS01505	COG1302	Protein conserved in bacteria
B4072_RS01510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B4072_RS01520	COG1564	THIamine pyrophosphokinase
B4072_RS01525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4072_RS01530	COG1162	GTPase activity
B4072_RS01535	COG2815	serine threonine protein kinase
B4072_RS01535	COG0515	serine threonine protein kinase
B4072_RS01540	COG0631	protein serine/threonine phosphatase activity
B4072_RS01545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B4072_RS01550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4072_RS01550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4072_RS01555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4072_RS01560	COG0242	peptide deformylase activity
B4072_RS01565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4072_RS01570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4072_RS01575	COG1758	RNA polymerase activity
B4072_RS01580	COG0194	GDP metabolic process
B4072_RS01590	COG1561	YicC-like family, N-terminal region
B4072_RS01595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4072_RS01600	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B4072_RS01605	COG1648	precorrin-2 dehydrogenase activity
B4072_RS01610	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B4072_RS01615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4072_RS01620	COG0529	Catalyzes the synthesis of activated sulfate
B4072_RS01625	COG2046	Belongs to the sulfate adenylyltransferase family
B4072_RS01630	COG0306	phosphate transporter
B4072_RS01635	COG0175	sulfate reduction
B4072_RS01645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B4072_RS01650	COG0284	orotidine-5'-phosphate decarboxylase activity
B4072_RS01655	COG0167	dihydroorotate dehydrogenase activity
B4072_RS01660	COG0543	2 iron, 2 sulfur cluster binding
B4072_RS01665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4072_RS01670	COG0505	Belongs to the CarA family
B4072_RS01675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4072_RS01680	COG0540	Belongs to the ATCase OTCase family
B4072_RS01685	COG2233	PERMEase
B4072_RS01690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B4072_RS01695	COG0564	pseudouridine synthase activity
B4072_RS01700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B4072_RS01705	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4072_RS01710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B4072_RS01715	COG3599	regulation of cell shape
B4072_RS01720	COG2302	S4 RNA-binding domain
B4072_RS01725	COG0762	integral membrane protein
B4072_RS01730	COG1799	cell septum assembly
B4072_RS01735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4072_RS01740	COG1496	oxidoreductase activity
B4072_RS01745	COG1873	PFAM PRC-barrel domain
B4072_RS01750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4072_RS01755	COG1119	ATPase activity
B4072_RS01760	COG1191	sigma factor activity
B4072_RS01765	COG1191	sigma factor activity
B4072_RS01775	COG1404	Belongs to the peptidase S8 family
B4072_RS01775	COG4412	M6 family metalloprotease domain protein
B4072_RS01780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B4072_RS01785	COG0849	cell division
B4072_RS01790	COG3856	small basic protein
B4072_RS01795	COG3879	Bacterial protein of unknown function (DUF881)
B4072_RS01800	COG3879	Bacterial protein of unknown function (DUF881)
B4072_RS01805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4072_RS01810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B4072_RS01815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4072_RS01820	COG0772	Belongs to the SEDS family
B4072_RS01825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4072_RS01830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4072_RS01840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4072_RS01850	COG0768	penicillin binding
B4072_RS01860	COG0768	penicillin binding
B4072_RS01865	COG4839	cell division protein FtsL
B4072_RS01870	COG0275	rRNA processing
B4072_RS01875	COG2001	Belongs to the MraZ family
B4072_RS01880	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B4072_RS01885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4072_RS01890	COG0454	-acetyltransferase
B4072_RS01905	COG1399	metal-binding, possibly nucleic acid-binding protein
B4072_RS01915	COG1323	Belongs to the UPF0348 family
B4072_RS01920	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4072_RS01925	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4072_RS01930	COG3314	Sporulation integral membrane protein YlbJ
B4072_RS01935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B4072_RS01940	COG0742	ribosomal rna small subunit methyltransferase
B4072_RS01945	COG4471	UPF0298 protein
B4072_RS01950	COG3679	Belongs to the UPF0342 family
B4072_RS01965	COG2340	Cysteine-rich secretory protein family
B4072_RS01970	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B4072_RS01980	COG3336	cytochrome c oxidase
B4072_RS01985	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B4072_RS01990	COG1845	cytochrome c oxidase, subunit III
B4072_RS01995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4072_RS02000	COG2010	Cytochrome c
B4072_RS02000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4072_RS02005	COG0109	protoheme IX farnesyltransferase activity
B4072_RS02010	COG1612	heme a metabolic process
B4072_RS02015	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B4072_RS02020	COG0772	Belongs to the SEDS family
B4072_RS02025	COG4838	Belongs to the UPF0358 family
B4072_RS02030	COG2066	Belongs to the glutaminase family
B4072_RS02035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4072_RS02040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B4072_RS02050	COG4896	Protein conserved in bacteria
B4072_RS02060	COG1217	gtp-binding protein TYPA
B4072_RS02080	COG1595	DNA-templated transcription, initiation
B4072_RS02100	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B4072_RS02110	COG0483	inositol monophosphate 1-phosphatase activity
B4072_RS02120	COG4493	Belongs to the UPF0637 family
B4072_RS02125	COG4476	Belongs to the UPF0223 family
B4072_RS02130	COG1982	Orn Lys Arg decarboxylase major
B4072_RS02135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS02140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4072_RS02145	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4072_RS02150	COG0022	dehydrogenase e1 component
B4072_RS02155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4072_RS02160	COG0497	DNA recombination
B4072_RS02170	COG0242	peptide deformylase activity
B4072_RS02175	COG0561	phosphatase activity
B4072_RS02180	COG5503	Protein of unknown function (DUF1447)
B4072_RS02185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4072_RS02190	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4072_RS02195	COG0569	domain protein
B4072_RS02200	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B4072_RS02200	COG2105	PFAM AIG2 family protein
B4072_RS02205	COG3852	Histidine kinase
B4072_RS02210	COG2002	toxin-antitoxin pair type II binding
B4072_RS02215	COG1077	Cell shape determining protein MreB Mrl
B4072_RS02225	COG2309	aminopeptidase activity
B4072_RS02230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4072_RS02235	COG0488	(ABC) transporter
B4072_RS02245	COG0681	Belongs to the peptidase S26 family
B4072_RS02250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4072_RS02250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4072_RS02250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4072_RS02255	COG1105	Belongs to the carbohydrate kinase PfkB family
B4072_RS02260	COG1349	DNA-binding transcription factor activity
B4072_RS02265	COG0577	efflux transmembrane transporter activity
B4072_RS02270	COG1136	(ABC) transporter
B4072_RS02275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4072_RS02285	COG1132	(ABC) transporter
B4072_RS02290	COG1132	(ABC) transporter
B4072_RS02295	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B4072_RS02300	COG0314	molybdopterin synthase activity
B4072_RS02305	COG1763	Mo-molybdopterin cofactor biosynthetic process
B4072_RS02310	COG0303	'Molybdopterin
B4072_RS02315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4072_RS02320	COG0746	molybdenum cofactor guanylyltransferase activity
B4072_RS02335	COG2801	Transposase and inactivated derivatives
B4072_RS02345	COG1476	TRANSCRIPTIONal
B4072_RS02355	COG3239	Fatty acid desaturase
B4072_RS02360	COG1278	Cold shock
B4072_RS02365	COG1329	Transcriptional regulator
B4072_RS02370	COG0697	spore germination
B4072_RS02375	COG1917	Cupin 2, conserved barrel domain protein
B4072_RS02375	COG2207	Transcriptional regulator
B4072_RS02380	COG0697	spore germination
B4072_RS02385	COG2207	Transcriptional regulator
B4072_RS02385	COG3708	Transcriptional regulator
B4072_RS02390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4072_RS02395	COG0477	Major facilitator Superfamily
B4072_RS02400	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B4072_RS02415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4072_RS02420	COG1309	transcriptional regulator
B4072_RS02425	COG0697	spore germination
B4072_RS02430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4072_RS02435	COG2030	dehydratase
B4072_RS02440	COG3545	Serine hydrolase
B4072_RS02445	COG1733	regulation of RNA biosynthetic process
B4072_RS02450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4072_RS02455	COG0640	Transcriptional regulator
B4072_RS02460	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4072_RS02465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4072_RS02470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4072_RS02475	COG0697	spore germination
B4072_RS02480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4072_RS02485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4072_RS02490	COG0640	Transcriptional regulator
B4072_RS02495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4072_RS02510	COG4585	Histidine kinase
B4072_RS02515	COG2197	response regulator
B4072_RS02520	COG2409	Drug exporters of the RND superfamily
B4072_RS02525	COG1811	Na channel or pump
B4072_RS02530	COG4978	Transcriptional regulator
B4072_RS02530	COG0789	Transcriptional regulator
B4072_RS02570	COG0135	phosphoribosylanthranilate isomerase activity
B4072_RS02580	COG3507	Belongs to the glycosyl hydrolase 43 family
B4072_RS02585	COG1940	carbohydrate kinase activity
B4072_RS02590	COG2115	Belongs to the xylose isomerase family
B4072_RS02595	COG1070	Carbohydrate kinase
B4072_RS02605	COG4463	regulation of RNA biosynthetic process
B4072_RS02610	COG3880	PFAM UvrB UvrC protein
B4072_RS02615	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B4072_RS02620	COG0542	response to heat
B4072_RS02625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4072_RS02630	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B4072_RS02635	COG4956	integral membrane protein (PIN domain superfamily)
B4072_RS02640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B4072_RS02645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B4072_RS02650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B4072_RS02660	COG1045	serine acetyltransferase
B4072_RS02665	COG0215	cysteine-tRNA ligase activity
B4072_RS02670	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B4072_RS02675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4072_RS02680	COG3688	RNA-binding protein containing a PIN domain
B4072_RS02685	COG1595	DNA-templated transcription, initiation
B4072_RS02695	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4072_RS02700	COG0250	Participates in transcription elongation, termination and antitermination
B4072_RS02710	COG0081	regulation of translation
B4072_RS02715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B4072_RS02725	COG2813	Specifically methylates the guanine in position
B4072_RS02730	COG0085	RNA polymerase activity
B4072_RS02735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B4072_RS02740	COG1358	cellular component organization or biogenesis
B4072_RS02745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B4072_RS02750	COG0049	tRNA binding
B4072_RS02755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B4072_RS02760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4072_RS02765	COG0596	Alpha beta hydrolase
B4072_RS02775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B4072_RS02780	COG0088	Forms part of the polypeptide exit tunnel
B4072_RS02790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B4072_RS02805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B4072_RS02810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B4072_RS02820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B4072_RS02835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B4072_RS02845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B4072_RS02850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B4072_RS02855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B4072_RS02860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B4072_RS02870	COG0200	Binds to the 23S rRNA
B4072_RS02875	COG0201	protein transport
B4072_RS02880	COG0563	adenylate kinase activity
B4072_RS02885	COG0024	Methionine aminopeptidase
B4072_RS02890	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B4072_RS02900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4072_RS02905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B4072_RS02910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B4072_RS02915	COG0202	RNA polymerase activity
B4072_RS02920	COG0203	ribosomal protein L17
B4072_RS02925	COG1122	ATPase activity
B4072_RS02930	COG1122	ATPase activity
B4072_RS02935	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4072_RS02940	COG0101	tRNA pseudouridine synthase activity
B4072_RS02945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B4072_RS02950	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B4072_RS02960	COG2226	methyltransferase
B4072_RS02970	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4072_RS02975	COG0489	protein tyrosine kinase activity
B4072_RS02985	COG2194	sulfuric ester hydrolase activity
B4072_RS02990	COG0726	polysaccharide deacetylase
B4072_RS02995	COG2340	Cysteine-rich secretory protein family
B4072_RS03000	COG0768	penicillin binding
B4072_RS03005	COG4191	Histidine kinase
B4072_RS03010	COG0436	Aminotransferase
B4072_RS03020	COG0784	Response regulator, receiver
B4072_RS03020	COG0835	chemotaxis
B4072_RS03030	COG2814	Major facilitator Superfamily
B4072_RS03035	COG1376	ErfK ybiS ycfS ynhG family protein
B4072_RS03040	COG1408	metallophosphoesterase
B4072_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS03050	COG3409	Peptidoglycan-binding domain 1 protein
B4072_RS03060	COG2200	EAL domain
B4072_RS03070	COG4703	Protein of unknown function (DUF1797)
B4072_RS03075	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B4072_RS03085	COG0517	IMP dehydrogenase activity
B4072_RS03090	COG0583	DNA-binding transcription factor activity
B4072_RS03095	COG0716	FMN binding
B4072_RS03105	COG0716	FMN binding
B4072_RS03110	COG2171	N-acyltransferase activity
B4072_RS03115	COG1473	amidohydrolase
B4072_RS03125	COG0668	transmembrane transport
B4072_RS03130	COG0450	alkyl hydroperoxide reductase
B4072_RS03135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS03145	COG0693	protein deglycase activity
B4072_RS03160	COG5444	nuclease activity
B4072_RS03165	COG4282	regulation of fungal-type cell wall biogenesis
B4072_RS03170	COG1231	oxidoreductase activity
B4072_RS03180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4072_RS03185	COG2207	Transcriptional regulator
B4072_RS03185	COG0662	Cupin 2, conserved barrel domain protein
B4072_RS03190	COG0456	acetyltransferase
B4072_RS03195	COG1309	transcriptional regulator
B4072_RS03200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4072_RS03205	COG3708	Transcriptional regulator
B4072_RS03210	COG2378	regulation of single-species biofilm formation
B4072_RS03220	COG0640	Transcriptional regulator
B4072_RS03225	COG0741	lytic transglycosylase activity
B4072_RS03230	COG2322	membrane
B4072_RS03245	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4072_RS03250	COG3239	Fatty acid desaturase
B4072_RS03255	COG4585	Histidine kinase
B4072_RS03260	COG2197	response regulator
B4072_RS03265	COG3584	3D domain protein
B4072_RS03265	COG1388	LysM domain
B4072_RS03270	COG0514	ATP-dependent DNA helicase (RecQ)
B4072_RS03280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4072_RS03285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4072_RS03300	COG0071	Belongs to the small heat shock protein (HSP20) family
B4072_RS03325	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS03330	COG1657	PFAM Prenyltransferase squalene oxidase
B4072_RS03335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4072_RS03340	COG0733	neurotransmitter:sodium symporter activity
B4072_RS03345	COG0385	Bile acid
B4072_RS03350	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4072_RS03355	COG0567	Dehydrogenase, E1 component
B4072_RS03360	COG4548	von Willebrand factor, type A
B4072_RS03365	COG0714	Associated with various cellular activities
B4072_RS03370	COG2032	superoxide dismutase activity
B4072_RS03375	COG1388	LysM domain
B4072_RS03375	COG0791	NLP P60 protein
B4072_RS03380	COG1819	glycosyl
B4072_RS03385	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4072_RS03390	COG0534	Mate efflux family protein
B4072_RS03395	COG1366	Belongs to the anti-sigma-factor antagonist family
B4072_RS03400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4072_RS03405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4072_RS03415	COG2962	Rard protein
B4072_RS03430	COG2610	gluconate transmembrane transporter activity
B4072_RS03435	COG1942	4-Oxalocrotonate Tautomerase
B4072_RS03440	COG1733	regulation of RNA biosynthetic process
B4072_RS03445	COG0778	Nitroreductase
B4072_RS03450	COG2084	Dehydrogenase
B4072_RS03455	COG0840	transmembrane signaling receptor activity
B4072_RS03460	COG0456	acetyltransferase
B4072_RS03465	COG1533	DNA photolyase activity
B4072_RS03475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4072_RS03480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4072_RS03485	COG2190	(PTS) system
B4072_RS03485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4072_RS03485	COG1263	PTS System
B4072_RS03490	COG3711	transcriptional antiterminator
B4072_RS03505	COG0006	proline dipeptidase activity
B4072_RS03515	COG2217	Heavy metal translocating P-type atpase
B4072_RS03520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS03525	COG2244	polysaccharide biosynthetic process
B4072_RS03530	COG3773	Cell wall hydrolase
B4072_RS03545	COG4873	Protein conserved in bacteria
B4072_RS03555	COG3858	chitin binding
B4072_RS03560	COG1388	LysM domain
B4072_RS03565	COG1388	LysM domain
B4072_RS03565	COG4641	Protein conserved in bacteria
B4072_RS03570	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS03575	COG1733	regulation of RNA biosynthetic process
B4072_RS03580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B4072_RS03585	COG0602	queuosine metabolic process
B4072_RS03590	COG0720	synthase
B4072_RS03595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B4072_RS03600	COG3949	Membrane
B4072_RS03605	COG0542	response to heat
B4072_RS03610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4072_RS03615	COG1360	Flagellar Motor Protein
B4072_RS03620	COG1846	Transcriptional regulator
B4072_RS03625	COG3852	Histidine kinase
B4072_RS03640	COG3339	Conserved Protein
B4072_RS03645	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B4072_RS03650	COG0235	Class ii aldolase
B4072_RS03655	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B4072_RS03660	COG1850	ribulose-bisphosphate carboxylase activity
B4072_RS03665	COG0436	Aminotransferase
B4072_RS03670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4072_RS03675	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B4072_RS03680	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B4072_RS03690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4072_RS03695	COG5002	protein histidine kinase activity
B4072_RS03700	COG3594	Acyltransferase
B4072_RS03715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4072_RS03720	COG0501	Belongs to the peptidase M48B family
B4072_RS03740	COG1191	sigma factor activity
B4072_RS03745	COG0861	Integral membrane protein TerC family
B4072_RS03750	COG0586	Pfam SNARE associated Golgi protein
B4072_RS03760	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B4072_RS03765	COG1793	dna ligase
B4072_RS03765	COG3285	dna ligase
B4072_RS03770	COG0463	Glycosyl transferase, family 2
B4072_RS03780	COG1408	metallophosphoesterase
B4072_RS03785	COG0726	polysaccharide deacetylase
B4072_RS03790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4072_RS03795	COG1846	Transcriptional regulator
B4072_RS03810	COG0789	Transcriptional regulator
B4072_RS03815	COG2239	Acts as a magnesium transporter
B4072_RS03835	COG3212	peptidase
B4072_RS03840	COG3212	peptidase
B4072_RS03845	COG5002	protein histidine kinase activity
B4072_RS03845	COG3850	Histidine kinase
B4072_RS03850	COG0745	RESPONSE REGULATOR receiver
B4072_RS03860	COG4721	ABC-type cobalt transport system, permease component
B4072_RS03865	COG1122	ATPase activity
B4072_RS03870	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4072_RS03875	COG1366	Belongs to the anti-sigma-factor antagonist family
B4072_RS03880	COG1404	Belongs to the peptidase S8 family
B4072_RS03885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4072_RS03895	COG0590	tRNA wobble adenosine to inosine editing
B4072_RS03905	COG1764	response to oxidative stress
B4072_RS03910	COG1846	Transcriptional regulator
B4072_RS03915	COG1764	response to oxidative stress
B4072_RS03920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B4072_RS03925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4072_RS03930	COG0788	formyltetrahydrofolate deformylase activity
B4072_RS03935	COG2076	Multidrug Resistance protein
B4072_RS03940	COG2076	Multidrug Resistance protein
B4072_RS03945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4072_RS03950	COG2318	DinB family
B4072_RS03955	COG2323	membrane
B4072_RS03965	COG1017	nitric oxide dioxygenase activity
B4072_RS03965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B4072_RS03970	COG1607	acyl-coa hydrolase
B4072_RS03975	COG1834	amidinotransferase
B4072_RS03980	COG2706	6-phosphogluconolactonase activity
B4072_RS03985	COG4608	Belongs to the ABC transporter superfamily
B4072_RS03990	COG0791	NLP P60 protein
B4072_RS03995	COG4948	Mandelate Racemase Muconate Lactonizing
B4072_RS04000	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4072_RS04005	COG4166	transmembrane transport
B4072_RS04010	COG0444	Belongs to the ABC transporter superfamily
B4072_RS04015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4072_RS04020	COG0601	transmembrane transport
B4072_RS04025	COG2362	D-Aminopeptidase
B4072_RS04030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4072_RS04035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4072_RS04045	COG0463	Glycosyl transferase, family 2
B4072_RS04050	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B4072_RS04055	COG0346	lactoylglutathione lyase activity
B4072_RS04060	COG0531	amino acid
B4072_RS04065	COG1392	Phosphate transport regulator
B4072_RS04070	COG0306	phosphate transporter
B4072_RS04085	COG3409	Peptidoglycan-binding domain 1 protein
B4072_RS04085	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4072_RS04125	COG3778	Protein conserved in bacteria
B4072_RS04130	COG3299	homolog of phage Mu protein gp47
B4072_RS04135	COG3628	GPW Gp25 family protein
B4072_RS04145	COG4193	domain, Protein
B4072_RS04150	COG1652	LysM domain
B4072_RS04155	COG5412	phage tail tape measure protein
B4072_RS04155	COG3953	SLT domain
B4072_RS04205	COG4653	Phage capsid family
B4072_RS04210	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B4072_RS04215	COG5518	Phage portal protein
B4072_RS04220	COG1783	phage Terminase large subunit
B4072_RS04225	COG5484	DNA packaging
B4072_RS04225	COG3728	DNA packaging
B4072_RS04230	COG1595	DNA-templated transcription, initiation
B4072_RS04255	COG1484	DNA-dependent DNA replication
B4072_RS04260	COG1522	sequence-specific DNA binding
B4072_RS04270	COG1396	sequence-specific DNA binding
B4072_RS04275	COG2856	Zn peptidase
B4072_RS04280	COG3546	catalase activity
B4072_RS04285	COG4195	phage-related replication protein
B4072_RS04295	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4072_RS04295	COG3409	Peptidoglycan-binding domain 1 protein
B4072_RS04295	COG1388	LysM domain
B4072_RS04300	COG2350	Protein conserved in bacteria
B4072_RS04310	COG0457	Tetratricopeptide repeat
B4072_RS04315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4072_RS04320	COG2318	DinB family
B4072_RS04325	COG0730	response to heat
B4072_RS04330	COG2721	sulfolactate sulfo-lyase activity
B4072_RS04335	COG0246	Mannitol dehydrogenase
B4072_RS04340	COG1609	Transcriptional regulator
B4072_RS04345	COG2271	Major facilitator Superfamily
B4072_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS04355	COG1312	Catalyzes the dehydration of D-mannonate
B4072_RS04360	COG1063	alcohol dehydrogenase
B4072_RS04365	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B4072_RS04370	COG2211	Major facilitator Superfamily
B4072_RS04375	COG1904	glucuronate isomerase
B4072_RS04380	COG1252	NADH dehydrogenase
B4072_RS04390	COG4297	protein containing double-stranded beta helix domain
B4072_RS04395	COG0697	spore germination
B4072_RS04400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4072_RS04405	COG0390	transport system, permease component
B4072_RS04410	COG1587	Uroporphyrinogen-III synthase
B4072_RS04420	COG1819	glycosyl
B4072_RS04425	COG2124	cytochrome p450
B4072_RS04435	COG1051	belongs to the nudix hydrolase family
B4072_RS04445	COG2427	Protein of unknown function (DUF1641)
B4072_RS04460	COG2205	protein histidine kinase activity
B4072_RS04465	COG5504	Zn-dependent protease
B4072_RS04490	COG1234	tRNA 3'-trailer cleavage
B4072_RS04495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4072_RS04500	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4072_RS04505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4072_RS04515	COG0706	membrane insertase activity
B4072_RS04520	COG3361	conserved protein (COG2071)
B4072_RS04545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4072_RS04550	COG0398	Pfam SNARE associated Golgi protein
B4072_RS04555	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4072_RS04555	COG3409	Peptidoglycan-binding domain 1 protein
B4072_RS04560	COG2755	lipolytic protein G-D-S-L family
B4072_RS04575	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4072_RS04580	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4072_RS04585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4072_RS04590	COG1534	Rna-binding protein
B4072_RS04595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B4072_RS04600	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4072_RS04605	COG0799	negative regulation of ribosome biogenesis
B4072_RS04610	COG2226	methyltransferase
B4072_RS04615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4072_RS04620	COG1555	photosystem II stabilization
B4072_RS04620	COG1596	polysaccharide export
B4072_RS04625	COG2131	deaminase
B4072_RS04630	COG2333	competence protein COMEC
B4072_RS04630	COG0658	competence protein
B4072_RS04640	COG1466	dna polymerase III delta subunit
B4072_RS04645	COG0268	Binds directly to 16S ribosomal RNA
B4072_RS04650	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B4072_RS04655	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4072_RS04665	COG0481	GTPase activity
B4072_RS04670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4072_RS04675	COG1420	regulation of RNA biosynthetic process
B4072_RS04680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B4072_RS04685	COG0443	Heat shock 70 kDa protein
B4072_RS04690	COG0484	heat shock protein binding
B4072_RS04695	COG2264	protein methyltransferase activity
B4072_RS04700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4072_RS04705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4072_RS04710	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4072_RS04720	COG1610	YqeY-like protein
B4072_RS04725	COG1030	water channel activity
B4072_RS04730	COG4864	UPF0365 protein
B4072_RS04745	COG0561	phosphatase activity
B4072_RS04750	COG1702	phosphate starvation-inducible protein PhoH
B4072_RS04760	COG1480	7TM receptor with intracellular HD hydrolase
B4072_RS04765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B4072_RS04770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4072_RS04775	COG0295	cytidine deaminase activity
B4072_RS04780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B4072_RS04790	COG1381	Involved in DNA repair and RecF pathway recombination
B4072_RS04795	COG0752	glycyl-tRNA synthetase alpha subunit
B4072_RS04800	COG0751	glycine-tRNA ligase activity
B4072_RS04805	COG0517	IMP dehydrogenase activity
B4072_RS04810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B4072_RS04815	COG1671	Belongs to the UPF0178 family
B4072_RS04820	COG0358	DNA primase activity
B4072_RS04825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4072_RS04830	COG2010	Cytochrome c
B4072_RS04835	COG2384	SAM-dependent methyltransferase
B4072_RS04840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B4072_RS04845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B4072_RS04855	COG0513	Belongs to the DEAD box helicase family
B4072_RS04860	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B4072_RS04870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4072_RS04875	COG0735	belongs to the Fur family
B4072_RS04880	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B4072_RS04885	COG4709	membrane
B4072_RS04890	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B4072_RS04895	COG1388	LysM domain
B4072_RS04900	COG5521	maltodextrose utilization protein MalA
B4072_RS04905	COG2839	Protein conserved in bacteria
B4072_RS04910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4072_RS04915	COG0477	Major facilitator Superfamily
B4072_RS04920	COG0768	penicillin binding
B4072_RS04925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4072_RS04930	COG0573	inorganic phosphate transmembrane transporter activity
B4072_RS04935	COG0581	inorganic phosphate transmembrane transporter activity
B4072_RS04940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4072_RS04945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4072_RS04950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4072_RS04965	COG0438	transferase activity, transferring glycosyl groups
B4072_RS04975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4072_RS04985	COG0457	Tetratricopeptide repeat
B4072_RS04985	COG0705	Rhomboid family
B4072_RS04990	COG4483	Protein conserved in bacteria
B4072_RS04995	COG1940	carbohydrate kinase activity
B4072_RS05000	COG1368	sulfuric ester hydrolase activity
B4072_RS05005	COG2866	Carboxypeptidase
B4072_RS05015	COG0011	TIGRFAM Protein of
B4072_RS05025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4072_RS05035	COG1393	Belongs to the ArsC family
B4072_RS05045	COG1366	Belongs to the anti-sigma-factor antagonist family
B4072_RS05050	COG1253	flavin adenine dinucleotide binding
B4072_RS05055	COG0598	Magnesium transport protein CorA
B4072_RS05060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4072_RS05065	COG1459	type II secretion system
B4072_RS05070	COG4537	Required for transformation and DNA binding
B4072_RS05075	COG4970	Tfp pilus assembly protein FimT
B4072_RS05085	COG4940	Competence protein ComGF
B4072_RS05110	COG0681	Belongs to the peptidase S26 family
B4072_RS05120	COG1396	sequence-specific DNA binding
B4072_RS05135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4072_RS05140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B4072_RS05145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4072_RS05150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4072_RS05155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4072_RS05160	COG0095	Lipoate-protein ligase
B4072_RS05165	COG1321	iron dependent repressor
B4072_RS05170	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4072_RS05180	COG3872	metal-dependent enzyme
B4072_RS05190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B4072_RS05195	COG0006	proline dipeptidase activity
B4072_RS05200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B4072_RS05210	COG3854	ATPases associated with a variety of cellular activities
B4072_RS05250	COG0511	ligase activity, forming carbon-carbon bonds
B4072_RS05255	COG0439	Biotin carboxylase
B4072_RS05260	COG1302	Protein conserved in bacteria
B4072_RS05265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4072_RS05270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B4072_RS05275	COG1570	exodeoxyribonuclease VII activity
B4072_RS05280	COG1722	exodeoxyribonuclease VII activity
B4072_RS05285	COG0142	geranyltranstransferase activity
B4072_RS05290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B4072_RS05295	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B4072_RS05300	COG1438	arginine binding
B4072_RS05305	COG0497	DNA recombination
B4072_RS05310	COG0750	zinc metalloprotease
B4072_RS05320	COG0745	RESPONSE REGULATOR receiver
B4072_RS05330	COG1902	pentaerythritol trinitrate reductase activity
B4072_RS05345	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4072_RS05350	COG0584	glycerophosphoryl diester phosphodiesterase
B4072_RS05355	COG0183	Belongs to the thiolase family
B4072_RS05360	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4072_RS05365	COG1960	acyl-CoA dehydrogenase activity
B4072_RS05370	COG0372	Belongs to the citrate synthase family
B4072_RS05375	COG2079	MmgE PrpD family protein
B4072_RS05380	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B4072_RS05390	COG3829	transcription factor binding
B4072_RS05390	COG3290	protein histidine kinase activity
B4072_RS05395	COG0280	phosphate acetyltransferase
B4072_RS05400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4072_RS05405	COG3426	butyrate kinase activity
B4072_RS05410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4072_RS05415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4072_RS05420	COG0022	dehydrogenase e1 component
B4072_RS05425	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4072_RS05430	COG0789	Transcriptional regulator
B4072_RS05430	COG4978	Transcriptional regulator
B4072_RS05435	COG2814	Major facilitator Superfamily
B4072_RS05440	COG1597	lipid kinase activity
B4072_RS05450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4072_RS05455	COG0765	amino acid transport
B4072_RS05460	COG1126	abc transporter atp-binding protein
B4072_RS05465	COG4129	membrane
B4072_RS05470	COG1376	ErfK ybiS ycfS ynhG family protein
B4072_RS05480	COG0346	lactoylglutathione lyase activity
B4072_RS05490	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4072_RS05500	COG2124	cytochrome p450
B4072_RS05500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4072_RS05505	COG1368	sulfuric ester hydrolase activity
B4072_RS05510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4072_RS05515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4072_RS05520	COG1442	glycosyl transferase family 8
B4072_RS05525	COG1216	Glycosyl transferase, family 2
B4072_RS05530	COG1442	glycosyl transferase family 8
B4072_RS05535	COG2223	nitrite transmembrane transporter activity
B4072_RS05540	COG1011	Hydrolase
B4072_RS05545	COG0531	amino acid
B4072_RS05550	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS05555	COG0840	transmembrane signaling receptor activity
B4072_RS05560	COG0488	(ABC) transporter
B4072_RS05570	COG0789	Transcriptional regulator
B4072_RS05575	COG2814	Major facilitator Superfamily
B4072_RS05610	COG4124	Belongs to the glycosyl hydrolase 26 family
B4072_RS05615	COG1482	cell wall glycoprotein biosynthetic process
B4072_RS05620	COG1940	carbohydrate kinase activity
B4072_RS05625	COG2188	Transcriptional regulator
B4072_RS05630	COG2723	6-phospho-beta-galactosidase activity
B4072_RS05640	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4072_RS05645	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4072_RS05650	COG2814	Major facilitator Superfamily
B4072_RS05655	COG1388	LysM domain
B4072_RS05660	COG1078	dGTPase activity
B4072_RS05665	COG0454	-acetyltransferase
B4072_RS05675	COG5646	InterPro IPR014922
B4072_RS05680	COG1785	Belongs to the alkaline phosphatase family
B4072_RS05690	COG1819	glycosyl
B4072_RS05695	COG3858	chitin binding
B4072_RS05695	COG1388	LysM domain
B4072_RS05700	COG1802	Transcriptional regulator
B4072_RS05705	COG0730	response to heat
B4072_RS05710	COG2814	Major facilitator Superfamily
B4072_RS05715	COG1846	Transcriptional regulator
B4072_RS05720	COG0778	Nitroreductase
B4072_RS05725	COG2409	Drug exporters of the RND superfamily
B4072_RS05725	COG1033	growth of symbiont in host cell
B4072_RS05730	COG1846	Transcriptional regulator
B4072_RS05735	COG2318	DinB family
B4072_RS05740	COG1113	amino acid transport
B4072_RS05750	COG0456	acetyltransferase
B4072_RS05760	COG1309	transcriptional regulator
B4072_RS05775	COG0071	Belongs to the small heat shock protein (HSP20) family
B4072_RS05780	COG2323	membrane
B4072_RS05805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS05810	COG2259	Doxx family
B4072_RS05815	COG0346	lactoylglutathione lyase activity
B4072_RS05820	COG0778	Nitroreductase
B4072_RS05825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4072_RS05840	COG5444	nuclease activity
B4072_RS05850	COG4282	regulation of fungal-type cell wall biogenesis
B4072_RS05865	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4072_RS05865	COG3409	Peptidoglycan-binding domain 1 protein
B4072_RS05925	COG1388	LysM domain
B4072_RS05925	COG0791	NLP P60 protein
B4072_RS05930	COG3953	SLT domain
B4072_RS05930	COG5280	Phage tail tape measure protein TP901
B4072_RS05995	COG5484	DNA packaging
B4072_RS06030	COG1595	DNA-templated transcription, initiation
B4072_RS06090	COG1484	DNA-dependent DNA replication
B4072_RS06095	COG3935	DnaD domain protein
B4072_RS06100	COG3723	Recombinational DNA repair protein, rece pathway
B4072_RS06105	COG5377	YqaJ viral recombinase family
B4072_RS06135	COG3645	SOS response
B4072_RS06135	COG3646	Phage regulatory protein
B4072_RS06150	COG3620	sequence-specific DNA binding
B4072_RS06160	COG2856	Zn peptidase
B4072_RS06165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4072_RS06195	COG2197	response regulator
B4072_RS06200	COG0824	Thioesterase
B4072_RS06205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4072_RS06210	COG1053	succinate dehydrogenase
B4072_RS06215	COG2009	succinate dehydrogenase
B4072_RS06225	COG1719	4-vinyl reductase, 4VR
B4072_RS06230	COG0527	aspartate kinase activity
B4072_RS06235	COG0322	excinuclease ABC activity
B4072_RS06240	COG3118	belongs to the thioredoxin family
B4072_RS06245	COG3534	alpha-L-arabinofuranosidase
B4072_RS06250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B4072_RS06255	COG2086	electron transfer activity
B4072_RS06260	COG1024	Enoyl-CoA hydratase
B4072_RS06265	COG1309	transcriptional regulator
B4072_RS06270	COG0318	PFAM AMP-dependent synthetase and ligase
B4072_RS06275	COG3766	membrane
B4072_RS06280	COG1193	negative regulation of DNA recombination
B4072_RS06285	COG1796	DNA polymerase
B4072_RS06285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4072_RS06290	COG1286	toxin biosynthetic process
B4072_RS06295	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B4072_RS06300	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4072_RS06305	COG0072	phenylalanine-tRNA ligase activity
B4072_RS06305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4072_RS06310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B4072_RS06320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4072_RS06330	COG3835	regulator
B4072_RS06335	COG0277	FAD linked oxidase domain protein
B4072_RS06340	COG0247	lactate metabolic process
B4072_RS06345	COG0346	lactoylglutathione lyase activity
B4072_RS06355	COG1966	Carbon starvation protein
B4072_RS06360	COG3534	alpha-L-arabinofuranosidase
B4072_RS06365	COG0395	ABC-type sugar transport system, permease component
B4072_RS06370	COG1175	transmembrane transport
B4072_RS06375	COG1653	transport
B4072_RS06380	COG0371	Dehydrogenase
B4072_RS06385	COG0647	UMP catabolic process
B4072_RS06390	COG0235	Class ii aldolase
B4072_RS06395	COG1069	ribulokinase activity
B4072_RS06400	COG2160	L-arabinose isomerase activity
B4072_RS06405	COG3507	Belongs to the glycosyl hydrolase 43 family
B4072_RS06410	COG1363	Peptidase, m42
B4072_RS06420	COG3326	Membrane
B4072_RS06425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B4072_RS06430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B4072_RS06435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4072_RS06445	COG1346	cytolysis
B4072_RS06450	COG1380	Effector of murein hydrolase LrgA
B4072_RS06455	COG3279	Response regulator of the LytR AlgR family
B4072_RS06460	COG3275	phosphorelay sensor kinase activity
B4072_RS06465	COG1011	Hydrolase
B4072_RS06470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4072_RS06480	COG0398	Pfam SNARE associated Golgi protein
B4072_RS06485	COG1484	DNA-dependent DNA replication
B4072_RS06490	COG3611	Membrane attachment protein
B4072_RS06495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B4072_RS06500	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4072_RS06505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4072_RS06515	COG2814	Major facilitator Superfamily
B4072_RS06520	COG0656	L-ascorbic acid biosynthetic process
B4072_RS06525	COG0237	dephospho-CoA kinase activity
B4072_RS06540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4072_RS06545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4072_RS06545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4072_RS06550	COG5002	protein histidine kinase activity
B4072_RS06555	COG0745	RESPONSE REGULATOR receiver
B4072_RS06560	COG0039	L-malate dehydrogenase activity
B4072_RS06565	COG0538	isocitrate dehydrogenase activity
B4072_RS06570	COG0372	Belongs to the citrate synthase family
B4072_RS06575	COG2707	UPF0756 membrane protein
B4072_RS06580	COG0628	permease
B4072_RS06585	COG3030	protein affecting phage T7 exclusion by the F plasmid
B4072_RS06590	COG0469	pyruvate kinase activity
B4072_RS06595	COG0205	6-phosphofructokinase activity
B4072_RS06600	COG0825	malonyl-CoA metabolic process
B4072_RS06605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B4072_RS06610	COG0281	malic enzyme
B4072_RS06615	COG0587	DNA-directed DNA polymerase activity
B4072_RS06635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4072_RS06645	COG4109	DRTGG domain
B4072_RS06655	COG0730	response to heat
B4072_RS06665	COG0196	riboflavin kinase activity
B4072_RS06670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4072_RS06675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B4072_RS06680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4072_RS06685	COG1126	abc transporter atp-binding protein
B4072_RS06690	COG0765	amino acid transport
B4072_RS06695	COG0765	amino acid transport
B4072_RS06700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4072_RS06705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4072_RS06710	COG0454	-acetyltransferase
B4072_RS06715	COG0583	DNA-binding transcription factor activity
B4072_RS06720	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B4072_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS06735	COG0165	Argininosuccinate lyase
B4072_RS06740	COG0137	argininosuccinate synthase activity
B4072_RS06745	COG0521	Mo-molybdopterin cofactor biosynthetic process
B4072_RS06750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B4072_RS06755	COG0827	DNA restriction-modification system
B4072_RS06760	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B4072_RS06765	COG3874	Sporulation protein YtfJ
B4072_RS06775	COG1714	RDD family
B4072_RS06780	COG0616	signal peptide processing
B4072_RS06785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4072_RS06790	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B4072_RS06795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4072_RS06805	COG0301	tRNA thio-modification
B4072_RS06810	COG1104	cysteine desulfurase activity
B4072_RS06815	COG1114	Component of the transport system for branched-chain amino acids
B4072_RS06820	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B4072_RS06825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4072_RS06830	COG1309	transcriptional regulator
B4072_RS06835	COG1956	GAF domain-containing protein
B4072_RS06840	COG0504	CTP synthase activity
B4072_RS06845	COG3343	RNA polymerase activity
B4072_RS06850	COG1960	acyl-CoA dehydrogenase activity
B4072_RS06855	COG2181	nitrate reductase activity
B4072_RS06855	COG0247	lactate metabolic process
B4072_RS06860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4072_RS06865	COG4294	response to UV
B4072_RS06875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4072_RS06885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4072_RS06895	COG2181	nitrate reductase activity
B4072_RS06900	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B4072_RS06905	COG1140	nitrate reductase beta subunit
B4072_RS06910	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B4072_RS06915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4072_RS06925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4072_RS06930	COG2223	nitrite transmembrane transporter activity
B4072_RS06935	COG0018	arginyl-trna synthetase
B4072_RS06940	COG4506	Protein conserved in bacteria
B4072_RS06950	COG0535	radical SAM domain protein
B4072_RS06960	COG1131	(ABC) transporter
B4072_RS06965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4072_RS06970	COG0612	Peptidase, M16
B4072_RS06975	COG0612	Peptidase, M16
B4072_RS06985	COG3391	amine dehydrogenase activity
B4072_RS06990	COG3391	amine dehydrogenase activity
B4072_RS07000	COG0457	Tetratricopeptide repeat
B4072_RS07015	COG0010	Belongs to the arginase family
B4072_RS07020	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B4072_RS07025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4072_RS07035	COG1994	Peptidase M50
B4072_RS07040	COG1942	4-Oxalocrotonate Tautomerase
B4072_RS07045	COG1846	Transcriptional regulator
B4072_RS07050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4072_RS07060	COG0477	Major facilitator Superfamily
B4072_RS07065	COG1959	2 iron, 2 sulfur cluster binding
B4072_RS07070	COG3465	dGTPase activity
B4072_RS07075	COG1078	dGTPase activity
B4072_RS07080	COG4844	belongs to the
B4072_RS07090	COG0697	spore germination
B4072_RS07095	COG0095	Lipoate-protein ligase
B4072_RS07100	COG0583	DNA-binding transcription factor activity
B4072_RS07105	COG0280	phosphate acetyltransferase
B4072_RS07110	COG3253	May function as heme-dependent peroxidase
B4072_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS07120	COG0436	Aminotransferase
B4072_RS07125	COG2814	Major facilitator Superfamily
B4072_RS07130	COG0151	Belongs to the GarS family
B4072_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS07145	COG0077	Prephenate dehydratase
B4072_RS07150	COG2814	Major facilitator Superfamily
B4072_RS07155	COG0833	amino acid
B4072_RS07160	COG4187	Peptidase family M20/M25/M40
B4072_RS07165	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS07180	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B4072_RS07185	COG1091	dTDP-4-dehydrorhamnose reductase activity
B4072_RS07190	COG1088	dTDP-glucose 4,6-dehydratase activity
B4072_RS07195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B4072_RS07200	COG3980	spore coat polysaccharide biosynthesis protein
B4072_RS07205	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
B4072_RS07210	COG2089	acid synthase
B4072_RS07215	COG0456	acetyltransferase
B4072_RS07220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4072_RS07225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4072_RS07230	COG0463	Glycosyl transferase, family 2
B4072_RS07245	COG2363	Small membrane protein
B4072_RS07260	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS07265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4072_RS07270	COG1216	Glycosyl transferase, family 2
B4072_RS07285	COG1695	Transcriptional regulator
B4072_RS07290	COG0351	phosphomethylpyrimidine kinase
B4072_RS07300	COG1621	beta-fructofuranosidase activity
B4072_RS07305	COG1263	PTS System
B4072_RS07305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4072_RS07310	COG2116	formate transmembrane transporter activity
B4072_RS07315	COG3711	transcriptional antiterminator
B4072_RS07325	COG1404	Belongs to the peptidase S8 family
B4072_RS07330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4072_RS07335	COG0778	Nitroreductase
B4072_RS07340	COG0772	Belongs to the SEDS family
B4072_RS07350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B4072_RS07355	COG1845	cytochrome c oxidase, subunit III
B4072_RS07360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4072_RS07365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4072_RS07370	COG2261	transglycosylase associated protein
B4072_RS07375	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B4072_RS07380	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B4072_RS07385	COG2246	polysaccharide biosynthetic process
B4072_RS07390	COG1309	transcriptional regulator
B4072_RS07400	COG3162	membrane
B4072_RS07405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4072_RS07410	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4072_RS07415	COG2837	iron assimilation
B4072_RS07420	COG2822	iron ion transport
B4072_RS07425	COG0672	)-iron permease
B4072_RS07430	COG0352	thiamine-phosphate diphosphorylase activity
B4072_RS07435	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B4072_RS07440	COG0583	DNA-binding transcription factor activity
B4072_RS07445	COG1380	Effector of murein hydrolase LrgA
B4072_RS07450	COG1346	cytolysis
B4072_RS07455	COG2814	Major facilitator Superfamily
B4072_RS07460	COG4895	conserved protein (DUF2196)
B4072_RS07465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4072_RS07470	COG0346	lactoylglutathione lyase activity
B4072_RS07480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4072_RS07485	COG1404	Belongs to the peptidase S8 family
B4072_RS07490	COG1263	PTS System
B4072_RS07490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4072_RS07495	COG3711	transcriptional antiterminator
B4072_RS07500	COG1442	glycosyl transferase family 8
B4072_RS07505	COG5522	Integral membrane protein (intg_mem_TP0381)
B4072_RS07510	COG1846	Transcriptional regulator
B4072_RS07515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4072_RS07520	COG2234	aminopeptidase activity
B4072_RS07535	COG2814	Major facilitator Superfamily
B4072_RS07540	COG2357	RelA SpoT domain protein
B4072_RS07545	COG1575	Belongs to the MenA family. Type 1 subfamily
B4072_RS07560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4072_RS07565	COG1696	Membrane protein involved in D-alanine export
B4072_RS07570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4072_RS07575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B4072_RS07580	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B4072_RS07585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4072_RS07590	COG1486	melibiose metabolic process
B4072_RS07595	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4072_RS07600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4072_RS07605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4072_RS07610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4072_RS07610	COG3711	transcriptional antiterminator
B4072_RS07620	COG2094	Belongs to the DNA glycosylase MPG family
B4072_RS07625	COG0753	catalase activity
B4072_RS07630	COG2814	Major facilitator Superfamily
B4072_RS07635	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4072_RS07640	COG1131	(ABC) transporter
B4072_RS07660	COG1595	DNA-templated transcription, initiation
B4072_RS07665	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4072_RS07670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B4072_RS07675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4072_RS07680	COG4988	ABC transporter
B4072_RS07685	COG1294	oxidase, subunit
B4072_RS07690	COG1271	oxidase subunit
B4072_RS07695	COG3493	citrate carrier protein
B4072_RS07700	COG0501	Belongs to the peptidase M48B family
B4072_RS07710	COG0726	polysaccharide deacetylase
B4072_RS07715	COG3842	ATPase activity
B4072_RS07720	COG2508	Transcriptional regulator
B4072_RS07725	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS07730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4072_RS07740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4072_RS07750	COG4585	Histidine kinase
B4072_RS07755	COG2197	response regulator
B4072_RS07760	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4072_RS07775	COG4894	glucomannan catabolic process
B4072_RS07780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4072_RS07785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4072_RS07795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4072_RS07800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4072_RS07805	COG2610	gluconate transmembrane transporter activity
B4072_RS07815	COG0500	methyltransferase
B4072_RS07820	COG0204	Acyl-transferase
B4072_RS07825	COG0667	Aldo Keto reductase
B4072_RS07830	COG1595	DNA-templated transcription, initiation
B4072_RS07845	COG0456	acetyltransferase
B4072_RS07850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4072_RS07855	COG0733	neurotransmitter:sodium symporter activity
B4072_RS07860	COG0531	amino acid
B4072_RS07865	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS07870	COG0372	Belongs to the citrate synthase family
B4072_RS07875	COG0583	DNA-binding transcription factor activity
B4072_RS07880	COG1388	LysM domain
B4072_RS07880	COG0791	NLP P60 protein
B4072_RS07885	COG1785	Belongs to the alkaline phosphatase family
B4072_RS07890	COG2719	SpoVR family
B4072_RS07895	COG0668	transmembrane transport
B4072_RS07900	COG1959	2 iron, 2 sulfur cluster binding
B4072_RS07905	COG0791	NLP P60 protein
B4072_RS07905	COG1388	LysM domain
B4072_RS07920	COG0431	NADPH-dependent FMN reductase
B4072_RS07925	COG2197	response regulator
B4072_RS07930	COG4585	Histidine kinase
B4072_RS07930	COG2203	Gaf domain
B4072_RS07935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4072_RS07940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4072_RS07945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4072_RS07950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4072_RS07955	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4072_RS07960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4072_RS07965	COG3153	acetyltransferase
B4072_RS07965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4072_RS07970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4072_RS07975	COG0517	IMP dehydrogenase activity
B4072_RS07985	COG0564	pseudouridine synthase activity
B4072_RS07990	COG3764	Sortase (surface protein transpeptidase)
B4072_RS07995	COG4085	toxin activity
B4072_RS07995	COG1525	nuclease
B4072_RS07995	COG0737	Belongs to the 5'-nucleotidase family
B4072_RS08000	COG5577	PFAM Coat F domain
B4072_RS08020	COG1823	symporter activity
B4072_RS08025	COG3706	GGDEF domain
B4072_RS08030	COG1464	Belongs to the NlpA lipoprotein family
B4072_RS08035	COG1278	Cold shock
B4072_RS08040	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4072_RS08045	COG1131	(ABC) transporter
B4072_RS08050	COG1131	(ABC) transporter
B4072_RS08055	COG1725	Transcriptional regulator
B4072_RS08070	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4072_RS08075	COG2814	Major facilitator Superfamily
B4072_RS08080	COG1566	PFAM secretion protein HlyD family protein
B4072_RS08085	COG1846	Transcriptional regulator
B4072_RS08095	COG2718	Belongs to the UPF0229 family
B4072_RS08100	COG2766	serine protein kinase
B4072_RS08105	COG1664	Polymer-forming cytoskeletal
B4072_RS08110	COG1664	Polymer-forming cytoskeletal
B4072_RS08115	COG0789	Transcriptional regulator
B4072_RS08120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4072_RS08130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4072_RS08135	COG3382	B3 4 domain protein
B4072_RS08145	COG1476	TRANSCRIPTIONal
B4072_RS08155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4072_RS08165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4072_RS08170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4072_RS08175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4072_RS08180	COG1116	anion transmembrane transporter activity
B4072_RS08185	COG0753	catalase activity
B4072_RS08195	COG0277	FAD linked oxidase domain protein
B4072_RS08200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B4072_RS08205	COG3340	Belongs to the peptidase S51 family
B4072_RS08210	COG5577	PFAM Coat F domain
B4072_RS08220	COG4326	sporulation control protein
B4072_RS08225	COG4475	Protein of unknown function (DUF436)
B4072_RS08230	COG0698	ribose 5-phosphate isomerase
B4072_RS08235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4072_RS08240	COG1971	Probably functions as a manganese efflux pump
B4072_RS08245	COG0009	L-threonylcarbamoyladenylate synthase
B4072_RS08250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B4072_RS08270	COG2890	protein-(glutamine-N5) methyltransferase activity
B4072_RS08275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B4072_RS08285	COG0789	Transcriptional regulator
B4072_RS08290	COG0679	Auxin Efflux Carrier
B4072_RS08295	COG0281	malic enzyme
B4072_RS08300	COG1435	thymidine kinase activity
B4072_RS08310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4072_RS08320	COG1494	fructose-1,6-bisphosphatase
B4072_RS08325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4072_RS08330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4072_RS08335	COG0191	fructose-bisphosphate aldolase activity
B4072_RS08340	COG2204	response regulator
B4072_RS08345	COG4821	SIS domain
B4072_RS08365	COG3209	COG3209 Rhs family protein
B4072_RS08370	COG0697	spore germination
B4072_RS08375	COG0589	response to stress
B4072_RS08395	COG5444	nuclease activity
B4072_RS08430	COG3507	Belongs to the glycosyl hydrolase 43 family
B4072_RS08440	COG2986	histidine ammonia-lyase
B4072_RS08445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B4072_RS08450	COG1228	amidohydrolase
B4072_RS08455	COG0010	Belongs to the arginase family
B4072_RS08460	COG0833	amino acid
B4072_RS08465	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B4072_RS08470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4072_RS08475	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B4072_RS08480	COG2390	Transcriptional regulator
B4072_RS08490	COG3192	ethanolamine utilization protein
B4072_RS08495	COG2079	MmgE PrpD family protein
B4072_RS08500	COG1473	amidohydrolase
B4072_RS08505	COG1126	abc transporter atp-binding protein
B4072_RS08510	COG0765	amino acid transport
B4072_RS08515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4072_RS08520	COG0456	acetyltransferase
B4072_RS08525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4072_RS08530	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B4072_RS08535	COG0561	phosphatase activity
B4072_RS08565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4072_RS08570	COG5294	Protein conserved in bacteria
B4072_RS08575	COG0577	efflux transmembrane transporter activity
B4072_RS08580	COG1136	(ABC) transporter
B4072_RS08585	COG2205	protein histidine kinase activity
B4072_RS08590	COG0745	RESPONSE REGULATOR receiver
B4072_RS08595	COG0191	fructose-bisphosphate aldolase activity
B4072_RS08600	COG1082	Xylose isomerase domain protein TIM barrel
B4072_RS08605	COG1082	Xylose isomerase domain protein TIM barrel
B4072_RS08610	COG0673	inositol 2-dehydrogenase activity
B4072_RS08615	COG2814	Major facilitator Superfamily
B4072_RS08620	COG1082	Xylose isomerase domain protein TIM barrel
B4072_RS08625	COG3962	Belongs to the TPP enzyme family
B4072_RS08630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4072_RS08640	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS08645	COG1349	DNA-binding transcription factor activity
B4072_RS08650	COG0667	Aldo Keto reductase
B4072_RS08670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4072_RS08675	COG0670	Belongs to the BI1 family
B4072_RS08680	COG5583	Uncharacterized small protein (DUF2292)
B4072_RS08695	COG0346	lactoylglutathione lyase activity
B4072_RS08700	COG2329	Antibiotic biosynthesis monooxygenase
B4072_RS08705	COG2323	membrane
B4072_RS08710	COG1486	melibiose metabolic process
B4072_RS08715	COG0395	ABC-type sugar transport system, permease component
B4072_RS08720	COG4209	transmembrane transport
B4072_RS08725	COG1653	transport
B4072_RS08735	COG1874	Beta-galactosidase
B4072_RS08740	COG2755	lipolytic protein G-D-S-L family
B4072_RS08745	COG3401	FG-GAP repeat protein
B4072_RS08750	COG3401	FG-GAP repeat protein
B4072_RS08755	COG5578	integral membrane protein
B4072_RS08765	COG2755	lipolytic protein G-D-S-L family
B4072_RS08770	COG2207	Transcriptional regulator
B4072_RS08775	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B4072_RS08780	COG0395	ABC-type sugar transport system, permease component
B4072_RS08785	COG1175	transmembrane transport
B4072_RS08790	COG1653	transport
B4072_RS08795	COG2207	Transcriptional regulator
B4072_RS08795	COG4753	response regulator
B4072_RS08800	COG2972	Histidine kinase
B4072_RS08805	COG5578	integral membrane protein
B4072_RS08815	COG0454	-acetyltransferase
B4072_RS08820	COG3546	catalase activity
B4072_RS08835	COG1309	transcriptional regulator
B4072_RS08845	COG0217	transcriptional regulatory protein
B4072_RS08855	COG0457	Tetratricopeptide repeat
B4072_RS08865	COG5444	nuclease activity
B4072_RS08885	COG0457	Tetratricopeptide repeat
B4072_RS08895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4072_RS08900	COG1597	lipid kinase activity
B4072_RS08905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4072_RS08910	COG1309	transcriptional regulator
B4072_RS08915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4072_RS08920	COG0154	amidase activity
B4072_RS08925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4072_RS08930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4072_RS08935	COG1285	pathogenesis
B4072_RS08940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4072_RS08945	COG4851	CamS sex pheromone cAM373 precursor
B4072_RS08950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B4072_RS08955	COG0210	DNA helicase
B4072_RS08960	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B4072_RS08975	COG4496	protein, YerC YecD
B4072_RS08980	COG1470	cell adhesion involved in biofilm formation
B4072_RS08985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4072_RS08995	COG0531	amino acid
B4072_RS09000	COG1522	sequence-specific DNA binding
B4072_RS09005	COG0151	Belongs to the GarS family
B4072_RS09010	COG0138	bifunctional purine biosynthesis protein purh
B4072_RS09015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4072_RS09020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B4072_RS09025	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B4072_RS09030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4072_RS09035	COG0047	phosphoribosylformylglycinamidine synthase activity
B4072_RS09040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4072_RS09045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B4072_RS09050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4072_RS09055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B4072_RS09060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4072_RS09070	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B4072_RS09080	COG3064	Membrane
B4072_RS09085	COG2252	PERMEase
B4072_RS09100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B4072_RS09100	COG0519	Catalyzes the synthesis of GMP from XMP
B4072_RS09105	COG1305	Transglutaminase-like
B4072_RS09110	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B4072_RS09115	COG0714	Associated with various cellular activities
B4072_RS09120	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4072_RS09130	COG1113	amino acid transport
B4072_RS09135	COG2132	Multicopper oxidase
B4072_RS09145	COG2267	carboxylic ester hydrolase activity
B4072_RS09185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4072_RS09190	COG1959	2 iron, 2 sulfur cluster binding
B4072_RS09195	COG1104	cysteine desulfurase activity
B4072_RS09200	COG0482	sulfurtransferase activity
B4072_RS09205	COG0457	Tetratricopeptide repeat
B4072_RS09210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4072_RS09215	COG3881	PFAM PRC-barrel domain
B4072_RS09230	COG0765	amino acid transport
B4072_RS09235	COG0765	amino acid transport
B4072_RS09240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4072_RS09250	COG0628	permease
B4072_RS09255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4072_RS09260	COG4472	Bacterial protein of unknown function (DUF965)
B4072_RS09265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B4072_RS09270	COG3906	Belongs to the UPF0473 family
B4072_RS09275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4072_RS09280	COG4122	O-methyltransferase activity
B4072_RS09285	COG0826	peptidase U32
B4072_RS09290	COG0826	peptidase U32
B4072_RS09295	COG0572	uridine kinase
B4072_RS09300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4072_RS09305	COG0768	penicillin binding
B4072_RS09320	COG2226	methyltransferase
B4072_RS09325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4072_RS09330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4072_RS09335	COG0626	cystathionine gamma-synthase activity
B4072_RS09345	COG2427	Protein of unknown function (DUF1641)
B4072_RS09350	COG3383	formate dehydrogenase (NAD+) activity
B4072_RS09355	COG5609	conserved protein (DUF2294)
B4072_RS09360	COG2116	formate transmembrane transporter activity
B4072_RS09370	COG2226	methyltransferase
B4072_RS09375	COG1309	transcriptional regulator
B4072_RS09380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4072_RS09380	COG2124	cytochrome p450
B4072_RS09390	COG2755	lipolytic protein G-D-S-L family
B4072_RS09390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B4072_RS09400	COG1595	DNA-templated transcription, initiation
B4072_RS09405	COG1378	Sugar-specific transcriptional regulator TrmB
B4072_RS09410	COG1280	lysine exporter protein (LysE YggA)
B4072_RS09415	COG1113	amino acid transport
B4072_RS09430	COG0596	Alpha beta hydrolase
B4072_RS09435	COG5566	PFAM Mor transcription activator
B4072_RS09445	COG2828	Protein conserved in bacteria
B4072_RS09450	COG0583	DNA-binding transcription factor activity
B4072_RS09455	COG2851	Citrate transporter
B4072_RS09460	COG0667	Aldo Keto reductase
B4072_RS09465	COG1595	DNA-templated transcription, initiation
B4072_RS09470	COG3443	Belongs to the bacterial solute-binding protein 9 family
B4072_RS09485	COG0457	Tetratricopeptide repeat
B4072_RS09535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B4072_RS09540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B4072_RS09545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4072_RS09550	COG0590	tRNA wobble adenosine to inosine editing
B4072_RS09555	COG1335	isochorismatase
B4072_RS09560	COG3858	chitin binding
B4072_RS09560	COG1388	LysM domain
B4072_RS09565	COG1428	Deoxynucleoside kinase
B4072_RS09570	COG1428	Deoxynucleoside kinase
B4072_RS09580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B4072_RS09585	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B4072_RS09590	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B4072_RS09595	COG1686	Belongs to the peptidase S11 family
B4072_RS09600	COG0517	IMP dehydrogenase activity
B4072_RS09600	COG0516	GMP reductase activity
B4072_RS09610	COG0726	polysaccharide deacetylase
B4072_RS09620	COG0109	protoheme IX farnesyltransferase activity
B4072_RS09635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4072_RS09645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4072_RS09655	COG1482	cell wall glycoprotein biosynthetic process
B4072_RS09660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4072_RS09660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4072_RS09660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4072_RS09665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4072_RS09665	COG3711	transcriptional antiterminator
B4072_RS09675	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS09680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B4072_RS09740	COG1304	FMN binding
B4072_RS09745	COG0539	negative regulation of cytoplasmic translation
B4072_RS09750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B4072_RS09760	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B4072_RS09765	COG2959	enzyme of heme biosynthesis
B4072_RS09770	COG3773	Cell wall hydrolase
B4072_RS09770	COG3409	Peptidoglycan-binding domain 1 protein
B4072_RS09775	COG2339	peptidase activity
B4072_RS09780	COG0492	ferredoxin-NADP+ reductase activity
B4072_RS09785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4072_RS09790	COG4862	establishment of competence for transformation
B4072_RS09795	COG1408	metallophosphoesterase
B4072_RS09805	COG1388	LysM domain
B4072_RS09810	COG1266	CAAX protease self-immunity
B4072_RS09815	COG0514	ATP-dependent DNA helicase (RecQ)
B4072_RS09820	COG4955	Helix-turn-helix domain
B4072_RS09825	COG1141	Ferredoxin
B4072_RS09830	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B4072_RS09840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4072_RS09845	COG0710	3-dehydroquinate dehydratase activity
B4072_RS09855	COG1595	DNA-templated transcription, initiation
B4072_RS09860	COG5002	protein histidine kinase activity
B4072_RS09865	COG0745	RESPONSE REGULATOR receiver
B4072_RS09870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4072_RS09875	COG1333	cytochrome c biogenesis protein
B4072_RS09880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS09885	COG1187	pseudouridine synthase activity
B4072_RS09890	COG0700	Nucleoside recognition
B4072_RS09895	COG2715	membrane protein required for spore maturation
B4072_RS09900	COG1686	Belongs to the peptidase S11 family
B4072_RS09910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B4072_RS09915	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B4072_RS09920	COG1547	Domain of unknown function (DUF309)
B4072_RS09925	COG0456	acetyltransferase
B4072_RS09930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B4072_RS09935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4072_RS09935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4072_RS09940	COG0307	riboflavin synthase, alpha
B4072_RS09945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4072_RS09945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4072_RS09955	COG0681	Belongs to the peptidase S26 family
B4072_RS09965	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
B4072_RS09990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4072_RS09995	COG4086	secreted protein
B4072_RS10000	COG0019	diaminopimelate decarboxylase activity
B4072_RS10005	COG0697	spore germination
B4072_RS10020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4072_RS10040	COG1191	sigma factor activity
B4072_RS10045	COG2172	sigma factor antagonist activity
B4072_RS10050	COG1366	Belongs to the anti-sigma-factor antagonist family
B4072_RS10055	COG1686	Belongs to the peptidase S11 family
B4072_RS10060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B4072_RS10065	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B4072_RS10070	COG4974	Belongs to the 'phage' integrase family
B4072_RS10080	COG0735	belongs to the Fur family
B4072_RS10085	COG1300	Membrane
B4072_RS10095	COG0281	malic enzyme
B4072_RS10100	COG1757	Na H antiporter
B4072_RS10105	COG1027	Aspartate ammonia-lyase
B4072_RS10110	COG0252	asparaginase activity
B4072_RS10115	COG1396	sequence-specific DNA binding
B4072_RS10120	COG1379	DNA repair
B4072_RS10125	COG0494	nUDIX hydrolase
B4072_RS10135	COG0667	Aldo Keto reductase
B4072_RS10145	COG1073	alpha beta
B4072_RS10155	COG4918	Iron-sulphur cluster biosynthesis
B4072_RS10160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B4072_RS10160	COG0456	acetyltransferase
B4072_RS10165	COG2329	Antibiotic biosynthesis monooxygenase
B4072_RS10170	COG0456	acetyltransferase
B4072_RS10180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4072_RS10190	COG2211	Major facilitator Superfamily
B4072_RS10200	COG0346	lactoylglutathione lyase activity
B4072_RS10205	COG1072	(Pantothenic acid kinase))
B4072_RS10210	COG3048	D-serine ammonia-lyase activity
B4072_RS10215	COG0300	oxidoreductase activity
B4072_RS10220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4072_RS10225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4072_RS10230	COG4187	Peptidase family M20/M25/M40
B4072_RS10235	COG1902	pentaerythritol trinitrate reductase activity
B4072_RS10240	COG0596	Alpha beta hydrolase
B4072_RS10245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B4072_RS10250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B4072_RS10260	COG0356	it plays a direct role in the translocation of protons across the membrane
B4072_RS10275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B4072_RS10280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4072_RS10285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B4072_RS10290	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B4072_RS10295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4072_RS10300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B4072_RS10310	COG4836	Membrane
B4072_RS10320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4072_RS10325	COG2385	sporulation resulting in formation of a cellular spore
B4072_RS10330	COG2304	oxidoreductase activity
B4072_RS10340	COG2304	oxidoreductase activity
B4072_RS10350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B4072_RS10355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B4072_RS10360	COG0457	Tetratricopeptide repeat
B4072_RS10365	COG1994	Peptidase M50
B4072_RS10370	COG3237	CsbD-like
B4072_RS10400	COG0831	urea catabolic process
B4072_RS10405	COG0832	Belongs to the urease beta subunit family
B4072_RS10410	COG0804	urea catabolic process
B4072_RS10415	COG1959	2 iron, 2 sulfur cluster binding
B4072_RS10420	COG2910	NAD(P)H-binding
B4072_RS10430	COG0789	Transcriptional regulator
B4072_RS10435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4072_RS10455	COG1247	-acetyltransferase
B4072_RS10460	COG0739	heme binding
B4072_RS10465	COG1334	flagellar protein FlaG
B4072_RS10470	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B4072_RS10475	COG1516	flagellar protein fliS
B4072_RS10490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B4072_RS10495	COG0653	protein targeting
B4072_RS10500	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B4072_RS10505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4072_RS10510	COG2010	Cytochrome c
B4072_RS10515	COG2884	Cell division ATP-binding protein ftsE
B4072_RS10520	COG2177	Part of the ABC transporter FtsEX involved in
B4072_RS10525	COG3409	Peptidoglycan-binding domain 1 protein
B4072_RS10525	COG0793	Belongs to the peptidase S41A family
B4072_RS10535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4072_RS10540	COG2814	Major facilitator Superfamily
B4072_RS10545	COG1309	transcriptional regulator
B4072_RS10550	COG0574	Belongs to the PEP-utilizing enzyme family
B4072_RS10550	COG3848	Pyruvate phosphate dikinase
B4072_RS10555	COG4897	Protein conserved in bacteria
B4072_RS10560	COG0556	nucleotide-excision repair
B4072_RS10565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4072_RS10570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4072_RS10575	COG0719	Fe-S assembly protein
B4072_RS10580	COG0822	iron-sulfur transferase activity
B4072_RS10585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4072_RS10590	COG0719	Fe-S assembly protein
B4072_RS10595	COG0396	ATPase activity
B4072_RS10610	COG1464	Belongs to the NlpA lipoprotein family
B4072_RS10615	COG2011	ABC-type metal ion transport system permease component
B4072_RS10620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4072_RS10630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS10635	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4072_RS10645	COG0509	glycine decarboxylation via glycine cleavage system
B4072_RS10650	COG1393	Belongs to the ArsC family
B4072_RS10655	COG1960	acyl-CoA dehydrogenase activity
B4072_RS10660	COG0183	Belongs to the thiolase family
B4072_RS10665	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4072_RS10665	COG1024	Enoyl-CoA hydratase
B4072_RS10675	COG0506	proline dehydrogenase activity
B4072_RS10685	COG5577	PFAM Coat F domain
B4072_RS10690	COG1846	Transcriptional regulator
B4072_RS10695	COG0477	Major facilitator Superfamily
B4072_RS10700	COG1942	4-Oxalocrotonate Tautomerase
B4072_RS10705	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS10710	COG0583	DNA-binding transcription factor activity
B4072_RS10720	COG1120	ATPase activity
B4072_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS10740	COG0783	Belongs to the Dps family
B4072_RS10745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4072_RS10750	COG0745	RESPONSE REGULATOR receiver
B4072_RS10755	COG2770	Histidine kinase
B4072_RS10755	COG2205	protein histidine kinase activity
B4072_RS10765	COG1309	transcriptional regulator
B4072_RS10770	COG0114	fumarate hydratase activity
B4072_RS10780	COG0697	spore germination
B4072_RS10785	COG0814	amino acid
B4072_RS10795	COG2197	response regulator
B4072_RS10800	COG4585	Histidine kinase
B4072_RS10805	COG4758	membrane
B4072_RS10810	COG3595	metallopeptidase activity
B4072_RS10815	COG1842	Phage shock protein A
B4072_RS10820	COG4758	membrane
B4072_RS10825	COG2814	Major facilitator Superfamily
B4072_RS10830	COG2096	Adenosyltransferase
B4072_RS10835	COG1120	ATPase activity
B4072_RS10840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS10845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4072_RS10855	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS10860	COG3386	PFAM SMP-30 Gluconolaconase
B4072_RS10865	COG2205	protein histidine kinase activity
B4072_RS10870	COG0745	RESPONSE REGULATOR receiver
B4072_RS10880	COG1191	sigma factor activity
B4072_RS10890	COG2140	Oxalate decarboxylase
B4072_RS10900	COG0577	efflux transmembrane transporter activity
B4072_RS10905	COG1136	(ABC) transporter
B4072_RS10910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4072_RS10915	COG1120	ATPase activity
B4072_RS10920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS10925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS10930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4072_RS10940	COG0531	amino acid
B4072_RS10950	COG1988	membrane-bound metal-dependent
B4072_RS10955	COG1368	sulfuric ester hydrolase activity
B4072_RS10960	COG1910	domain protein
B4072_RS10965	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4072_RS10970	COG4149	molybdate abc transporter
B4072_RS10975	COG0656	L-ascorbic acid biosynthetic process
B4072_RS10985	COG0025	NhaP-type Na H and K H
B4072_RS10990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4072_RS10995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4072_RS11000	COG3973	AAA domain
B4072_RS11005	COG2860	membrane
B4072_RS11010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4072_RS11015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B4072_RS11020	COG2217	Heavy metal translocating P-type atpase
B4072_RS11025	COG2217	Heavy metal translocating P-type atpase
B4072_RS11030	COG2608	mercury ion transmembrane transporter activity
B4072_RS11035	COG1937	Protein conserved in bacteria
B4072_RS11040	COG0673	inositol 2-dehydrogenase activity
B4072_RS11045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4072_RS11050	COG1289	transmembrane transporter activity
B4072_RS11060	COG2076	Multidrug Resistance protein
B4072_RS11065	COG1309	transcriptional regulator
B4072_RS11070	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS11075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B4072_RS11080	COG0557	exoribonuclease II activity
B4072_RS11085	COG1647	Serine aminopeptidase, S33
B4072_RS11090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4072_RS11095	COG0596	Alpha beta hydrolase
B4072_RS11100	COG1476	TRANSCRIPTIONal
B4072_RS11105	COG1396	sequence-specific DNA binding
B4072_RS11110	COG1396	sequence-specific DNA binding
B4072_RS11115	COG1733	regulation of RNA biosynthetic process
B4072_RS11125	COG1174	glycine betaine transport
B4072_RS11130	COG1732	Glycine betaine
B4072_RS11135	COG1174	glycine betaine transport
B4072_RS11140	COG0517	IMP dehydrogenase activity
B4072_RS11140	COG1125	glycine betaine transport
B4072_RS11145	COG1510	regulation of RNA biosynthetic process
B4072_RS11165	COG5658	integral membrane protein
B4072_RS11170	COG0640	Transcriptional regulator
B4072_RS11175	COG1174	glycine betaine transport
B4072_RS11180	COG1732	Glycine betaine
B4072_RS11185	COG1174	glycine betaine transport
B4072_RS11195	COG1510	regulation of RNA biosynthetic process
B4072_RS11200	COG2095	MarC family integral membrane protein
B4072_RS11210	COG3064	Membrane
B4072_RS11215	COG4640	response to antibiotic
B4072_RS11220	COG0456	acetyltransferase
B4072_RS11225	COG0148	phosphopyruvate hydratase activity
B4072_RS11230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B4072_RS11235	COG0149	triose-phosphate isomerase activity
B4072_RS11240	COG0126	phosphoglycerate kinase activity
B4072_RS11250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4072_RS11255	COG2390	Transcriptional regulator
B4072_RS11260	COG2814	Major facilitator Superfamily
B4072_RS11265	COG1609	Transcriptional regulator
B4072_RS11270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4072_RS11275	COG0583	DNA-binding transcription factor activity
B4072_RS11280	COG0697	spore germination
B4072_RS11285	COG1113	amino acid transport
B4072_RS11290	COG3858	chitin binding
B4072_RS11295	COG1556	Lactate utilization protein
B4072_RS11300	COG1139	Iron-sulfur cluster binding protein
B4072_RS11305	COG0247	lactate metabolic process
B4072_RS11315	COG0596	Alpha beta hydrolase
B4072_RS11320	COG2208	phosphoserine phosphatase activity
B4072_RS11325	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B4072_RS11330	COG1874	Beta-galactosidase
B4072_RS11335	COG3833	ABC-type maltose transport systems, permease component
B4072_RS11350	COG1609	Transcriptional regulator
B4072_RS11355	COG2186	Transcriptional regulator
B4072_RS11360	COG1620	l-lactate permease
B4072_RS11365	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B4072_RS11375	COG5039	Polysaccharide pyruvyl transferase
B4072_RS11380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4072_RS11385	COG0110	maltose O-acetyltransferase activity
B4072_RS11390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4072_RS11395	COG2244	polysaccharide biosynthetic process
B4072_RS11400	COG1216	Glycosyl transferase, family 2
B4072_RS11405	COG5039	Polysaccharide pyruvyl transferase
B4072_RS11410	COG1216	Glycosyl transferase, family 2
B4072_RS11420	COG0438	transferase activity, transferring glycosyl groups
B4072_RS11425	COG1215	transferase activity, transferring glycosyl groups
B4072_RS11430	COG0438	transferase activity, transferring glycosyl groups
B4072_RS11435	COG1086	Polysaccharide biosynthesis protein
B4072_RS11440	COG0489	protein tyrosine kinase activity
B4072_RS11445	COG3944	biosynthesis protein
B4072_RS11450	COG1396	sequence-specific DNA binding
B4072_RS11455	COG2272	Belongs to the type-B carboxylesterase lipase family
B4072_RS11465	COG3479	Phenolic acid decarboxylase
B4072_RS11475	COG1794	racemase activity, acting on amino acids and derivatives
B4072_RS11480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4072_RS11485	COG1621	beta-fructofuranosidase activity
B4072_RS11490	COG1621	beta-fructofuranosidase activity
B4072_RS11500	COG1309	transcriptional regulator
B4072_RS11505	COG2076	Multidrug Resistance protein
B4072_RS11510	COG2076	Multidrug Resistance protein
B4072_RS11525	COG0740	serine-type endopeptidase activity
B4072_RS11530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4072_RS11535	COG0366	Alpha amylase catalytic
B4072_RS11540	COG1554	hydrolase, family 65, central catalytic
B4072_RS11545	COG5521	maltodextrose utilization protein MalA
B4072_RS11550	COG3833	ABC-type maltose transport systems, permease component
B4072_RS11555	COG1175	transmembrane transport
B4072_RS11560	COG2182	Extracellular solute-binding protein
B4072_RS11570	COG1609	Transcriptional regulator
B4072_RS11575	COG1611	Belongs to the LOG family
B4072_RS11585	COG0659	secondary active sulfate transmembrane transporter activity
B4072_RS11590	COG0288	reversible hydration of carbon dioxide
B4072_RS11595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4072_RS11600	COG0577	efflux transmembrane transporter activity
B4072_RS11605	COG1136	(ABC) transporter
B4072_RS11610	COG5002	protein histidine kinase activity
B4072_RS11615	COG0745	RESPONSE REGULATOR receiver
B4072_RS11625	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B4072_RS11630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4072_RS11635	COG1481	regulation of sporulation
B4072_RS11640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4072_RS11645	COG1660	Displays ATPase and GTPase activities
B4072_RS11650	COG1051	belongs to the nudix hydrolase family
B4072_RS11655	COG0492	ferredoxin-NADP+ reductase activity
B4072_RS11660	COG3883	PFAM NLP P60 protein
B4072_RS11660	COG0791	NLP P60 protein
B4072_RS11665	COG0457	Tetratricopeptide repeat
B4072_RS11690	COG0140	phosphoribosyl-ATP diphosphatase activity
B4072_RS11690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4072_RS11695	COG0107	imidazoleglycerol-phosphate synthase activity
B4072_RS11700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B4072_RS11705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B4072_RS11710	COG0131	Imidazoleglycerol-phosphate dehydratase
B4072_RS11715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B4072_RS11720	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B4072_RS11725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B4072_RS11730	COG4990	cell redox homeostasis
B4072_RS11735	COG5297	Belongs to the glycosyl hydrolase family 6
B4072_RS11740	COG0110	maltose O-acetyltransferase activity
B4072_RS11745	COG0546	phosphoglycolate phosphatase activity
B4072_RS11750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B4072_RS11755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B4072_RS11760	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B4072_RS11765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4072_RS11770	COG0363	glucosamine-6-phosphate deaminase activity
B4072_RS11775	COG2188	Transcriptional regulator
B4072_RS11780	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4072_RS11785	COG1846	Transcriptional regulator
B4072_RS11790	COG2124	cytochrome p450
B4072_RS11800	COG1846	Transcriptional regulator
B4072_RS11805	COG2814	Major facilitator Superfamily
B4072_RS11810	COG1950	PFAM Membrane protein of
B4072_RS11815	COG1983	PspC domain protein
B4072_RS11820	COG3595	metallopeptidase activity
B4072_RS11835	COG1253	flavin adenine dinucleotide binding
B4072_RS11840	COG0789	Transcriptional regulator
B4072_RS11845	COG0436	Aminotransferase
B4072_RS11855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4072_RS11860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4072_RS11865	COG0584	glycerophosphoryl diester phosphodiesterase
B4072_RS11875	COG0668	transmembrane transport
B4072_RS11880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B4072_RS11885	COG0726	polysaccharide deacetylase
B4072_RS11890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4072_RS11895	COG1757	Na H antiporter
B4072_RS11900	COG0589	response to stress
B4072_RS11910	COG1132	(ABC) transporter
B4072_RS11915	COG1132	(ABC) transporter
B4072_RS11920	COG0702	epimerase
B4072_RS11935	COG0189	ligase activity
B4072_RS11940	COG0189	ligase activity
B4072_RS11945	COG4399	Belongs to the UPF0754 family
B4072_RS11950	COG3679	Belongs to the UPF0342 family
B4072_RS11955	COG4335	DNA alkylation repair
B4072_RS11960	COG0561	phosphatase activity
B4072_RS11965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4072_RS11970	COG0475	glutathione-regulated potassium exporter activity
B4072_RS11975	COG0490	domain, Protein
B4072_RS11985	COG1024	Enoyl-CoA hydratase
B4072_RS11995	COG4152	abc transporter atp-binding protein
B4072_RS12000	COG1668	transmembrane transport
B4072_RS12005	COG0420	3'-5' exonuclease activity
B4072_RS12010	COG4717	serine-type aminopeptidase activity
B4072_RS12015	COG3481	metal-dependent phosphohydrolase, HD sub domain
B4072_RS12025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4072_RS12050	COG1846	Transcriptional regulator
B4072_RS12055	COG4980	gas vesicle protein
B4072_RS12070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B4072_RS12075	COG0537	adenosine 5'-monophosphoramidase activity
B4072_RS12080	COG1131	(ABC) transporter
B4072_RS12085	COG4473	ABC transporter
B4072_RS12095	COG1473	amidohydrolase
B4072_RS12100	COG3069	C4-dicarboxylate transmembrane transporter activity
B4072_RS12110	COG2329	Antibiotic biosynthesis monooxygenase
B4072_RS12115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4072_RS12120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4072_RS12125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B4072_RS12130	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B4072_RS12135	COG1309	transcriptional regulator
B4072_RS12140	COG1511	domain protein
B4072_RS12145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4072_RS12150	COG4377	Putative membrane peptidase family (DUF2324)
B4072_RS12160	COG1363	Peptidase, m42
B4072_RS12165	COG4405	Protein conserved in bacteria
B4072_RS12170	COG1301	dicarboxylic acid transport
B4072_RS12180	COG1234	tRNA 3'-trailer cleavage
B4072_RS12185	COG0095	Lipoate-protein ligase
B4072_RS12190	COG0702	epimerase
B4072_RS12195	COG0318	PFAM AMP-dependent synthetase and ligase
B4072_RS12205	COG0501	Belongs to the peptidase M48B family
B4072_RS12210	COG1404	Belongs to the peptidase S8 family
B4072_RS12215	COG0456	acetyltransferase
B4072_RS12220	COG0604	alcohol dehydrogenase
B4072_RS12225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4072_RS12230	COG0406	alpha-ribazole phosphatase activity
B4072_RS12235	COG0183	Belongs to the thiolase family
B4072_RS12240	COG0318	PFAM AMP-dependent synthetase and ligase
B4072_RS12245	COG1268	BioY protein
B4072_RS12250	COG0840	transmembrane signaling receptor activity
B4072_RS12260	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS12270	COG4903	ComK protein
B4072_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS12285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4072_RS12300	COG0398	Pfam SNARE associated Golgi protein
B4072_RS12305	COG0681	Belongs to the peptidase S26 family
B4072_RS12310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4072_RS12315	COG1846	Transcriptional regulator
B4072_RS12320	COG0738	Major facilitator superfamily
B4072_RS12325	COG0673	inositol 2-dehydrogenase activity
B4072_RS12330	COG0561	phosphatase activity
B4072_RS12340	COG1609	Transcriptional regulator
B4072_RS12345	COG3180	Ammonia monooxygenase
B4072_RS12350	COG2814	Major facilitator Superfamily
B4072_RS12350	COG0477	Major facilitator Superfamily
B4072_RS12355	COG4533	DNA binding
B4072_RS12365	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B4072_RS12370	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B4072_RS12375	COG1074	ATP-dependent DNA helicase activity
B4072_RS12385	COG0419	ATPase involved in DNA repair
B4072_RS12390	COG1403	HNH endonuclease
B4072_RS12435	COG5337	Spore coat protein CotH
B4072_RS12440	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4072_RS12450	COG1404	Belongs to the peptidase S8 family
B4072_RS12460	COG0367	asparagine synthase
B4072_RS12465	COG1562	ergosterol biosynthetic process
B4072_RS12470	COG0534	Mate efflux family protein
B4072_RS12475	COG2207	Transcriptional regulator
B4072_RS12475	COG1917	Cupin 2, conserved barrel domain protein
B4072_RS12485	COG0673	inositol 2-dehydrogenase activity
B4072_RS12490	COG2318	DinB family
B4072_RS12495	COG1279	arginine transmembrane transporter activity
B4072_RS12500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4072_RS12505	COG1357	PFAM Pentapeptide repeats (8 copies)
B4072_RS12510	COG2267	carboxylic ester hydrolase activity
B4072_RS12515	COG0529	Catalyzes the synthesis of activated sulfate
B4072_RS12530	COG2045	Belongs to the ComB family
B4072_RS12535	COG1809	phosphosulfolactate synthase activity
B4072_RS12540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4072_RS12545	COG4948	Mandelate Racemase Muconate Lactonizing
B4072_RS12595	COG0776	regulation of translation
B4072_RS12650	COG0210	DNA helicase
B4072_RS12665	COG3655	Transcriptional regulator
B4072_RS12740	COG0582	viral genome integration into host DNA
B4072_RS12755	COG3655	Transcriptional regulator
B4072_RS12845	COG1793	dna ligase
B4072_RS12850	COG2135	peptidase activity
B4072_RS12905	COG2887	Belongs to the helicase family. UvrD subfamily
B4072_RS12915	COG0305	Participates in initiation and elongation during chromosome replication
B4072_RS12920	COG0358	DNA primase activity
B4072_RS12925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4072_RS12930	COG0587	DNA-directed DNA polymerase activity
B4072_RS12935	COG3584	3D domain protein
B4072_RS12960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4072_RS12965	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B4072_RS13050	COG1780	Probably involved in ribonucleotide reductase function
B4072_RS13055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4072_RS13055	COG1372	Participates in initiation and elongation during chromosome replication
B4072_RS13060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4072_RS13060	COG1372	Participates in initiation and elongation during chromosome replication
B4072_RS13070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4072_RS13080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4072_RS13085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS13105	COG0756	dUTP diphosphatase activity
B4072_RS13110	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B4072_RS13140	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B4072_RS13145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4072_RS13240	COG3331	DNA recombination
B4072_RS13260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4072_RS13265	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B4072_RS13270	COG0789	Transcriptional regulator
B4072_RS13275	COG0174	glutamine synthetase
B4072_RS13290	COG5444	nuclease activity
B4072_RS13320	COG4282	regulation of fungal-type cell wall biogenesis
B4072_RS13335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4072_RS13340	COG1846	Transcriptional regulator
B4072_RS13345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B4072_RS13350	COG5401	PFAM Sporulation and spore germination
B4072_RS13355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B4072_RS13360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B4072_RS13365	COG0622	Phosphoesterase
B4072_RS13375	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
B4072_RS13385	COG0454	-acetyltransferase
B4072_RS13395	COG0028	Belongs to the TPP enzyme family
B4072_RS13400	COG0440	acetolactate synthase activity
B4072_RS13405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B4072_RS13410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4072_RS13415	COG0473	3-isopropylmalate dehydrogenase activity
B4072_RS13420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4072_RS13425	COG0066	3-isopropylmalate dehydratase activity
B4072_RS13430	COG0457	Tetratricopeptide repeat
B4072_RS13430	COG1477	protein flavinylation
B4072_RS13435	COG0544	peptidyl-prolyl cis-trans isomerase activity
B4072_RS13440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B4072_RS13445	COG1067	ATP-dependent peptidase activity
B4072_RS13445	COG0470	DNA polymerase III
B4072_RS13450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4072_RS13455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B4072_RS13465	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B4072_RS13470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4072_RS13475	COG0181	hydroxymethylbilane synthase activity
B4072_RS13480	COG1587	Uroporphyrinogen-III synthase
B4072_RS13485	COG0113	porphobilinogen synthase activity
B4072_RS13490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4072_RS13495	COG1388	LysM domain
B4072_RS13500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4072_RS13510	COG0525	valine-tRNA ligase activity
B4072_RS13515	COG0285	dihydrofolate synthase activity
B4072_RS13520	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4072_RS13530	COG0424	maF-like protein
B4072_RS13535	COG2003	Belongs to the UPF0758 family
B4072_RS13540	COG1077	Cell shape determining protein MreB Mrl
B4072_RS13550	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B4072_RS13555	COG0850	regulation of cytokinetic process
B4072_RS13560	COG2894	cell division
B4072_RS13565	COG0739	heme binding
B4072_RS13570	COG1994	Peptidase M50
B4072_RS13575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B4072_RS13580	COG2868	ribosomal protein
B4072_RS13585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B4072_RS13595	COG3290	protein histidine kinase activity
B4072_RS13600	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B4072_RS13605	COG4492	Belongs to the UPF0735 family
B4072_RS13610	COG0077	Prephenate dehydratase
B4072_RS13615	COG1827	regulation of RNA biosynthetic process
B4072_RS13620	COG1104	cysteine desulfurase activity
B4072_RS13625	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4072_RS13630	COG0157	Belongs to the NadC ModD family
B4072_RS13635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B4072_RS13640	COG1388	LysM domain
B4072_RS13650	COG0217	transcriptional regulatory protein
B4072_RS13655	COG1115	amino acid carrier protein
B4072_RS13675	COG2112	serine threonine protein kinase
B4072_RS13680	COG0673	inositol 2-dehydrogenase activity
B4072_RS13685	COG2814	Major facilitator Superfamily
B4072_RS13695	COG0632	four-way junction helicase activity
B4072_RS13700	COG2255	four-way junction helicase activity
B4072_RS13710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B4072_RS13715	COG0343	queuine tRNA-ribosyltransferase activity
B4072_RS13720	COG1862	Preprotein translocase
B4072_RS13730	COG2323	membrane
B4072_RS13735	COG2244	polysaccharide biosynthetic process
B4072_RS13745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4072_RS13745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4072_RS13750	COG0490	domain, Protein
B4072_RS13755	COG5416	Lipopolysaccharide assembly protein A domain
B4072_RS13760	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4072_RS13760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4072_RS13765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4072_RS13770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4072_RS13775	COG1490	D-aminoacyl-tRNA deacylase activity
B4072_RS13780	COG4991	sh3 domain protein
B4072_RS13780	COG3103	Sh3 type 3 domain protein
B4072_RS13780	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4072_RS13790	COG0124	histidyl-tRNA synthetase
B4072_RS13795	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B4072_RS13805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4072_RS13815	COG0243	molybdopterin cofactor binding
B4072_RS13820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4072_RS13825	COG1070	Carbohydrate kinase
B4072_RS13830	COG2814	Major facilitator Superfamily
B4072_RS13835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4072_RS13845	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4072_RS13850	COG0300	oxidoreductase activity
B4072_RS13860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4072_RS13865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4072_RS13870	COG0583	DNA-binding transcription factor activity
B4072_RS13875	COG0067	glutamate synthase
B4072_RS13875	COG0069	glutamate synthase activity
B4072_RS13875	COG0070	glutamate synthase
B4072_RS13880	COG0493	'glutamate synthase
B4072_RS13885	COG0604	alcohol dehydrogenase
B4072_RS13890	COG0583	DNA-binding transcription factor activity
B4072_RS13895	COG0405	Gamma-glutamyltransferase
B4072_RS13900	COG0166	Belongs to the GPI family
B4072_RS13905	COG0582	viral genome integration into host DNA
B4072_RS13920	COG0534	Mate efflux family protein
B4072_RS13925	COG2017	converts alpha-aldose to the beta-anomer
B4072_RS13930	COG2027	D-alanyl-D-alanine carboxypeptidase
B4072_RS13935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4072_RS13950	COG1649	PFAM Uncharacterised BCR, COG1649
B4072_RS13965	COG1960	acyl-CoA dehydrogenase activity
B4072_RS13970	COG0318	PFAM AMP-dependent synthetase and ligase
B4072_RS13975	COG0439	Biotin carboxylase
B4072_RS13980	COG0511	ligase activity, forming carbon-carbon bonds
B4072_RS13985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4072_RS13990	COG1024	Enoyl-CoA hydratase
B4072_RS13995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4072_RS14000	COG2404	hydrolase activity, acting on ester bonds
B4072_RS14005	COG0586	Pfam SNARE associated Golgi protein
B4072_RS14010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4072_RS14015	COG2246	polysaccharide biosynthetic process
B4072_RS14020	COG3507	Belongs to the glycosyl hydrolase 43 family
B4072_RS14035	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4072_RS14040	COG1115	amino acid carrier protein
B4072_RS14055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4072_RS14060	COG0187	DNA topoisomerase II activity
B4072_RS14065	COG1832	CoA-binding protein
B4072_RS14070	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B4072_RS14075	COG4841	protein insertion into membrane
B4072_RS14085	COG0824	Thioesterase
B4072_RS14105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS14110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4072_RS14125	COG0071	Belongs to the small heat shock protein (HSP20) family
B4072_RS14140	COG5444	nuclease activity
B4072_RS14170	COG0741	lytic transglycosylase activity
B4072_RS14170	COG1196	nuclear chromosome segregation
B4072_RS14170	COG0739	heme binding
B4072_RS14215	COG5505	Protein of unknown function (DUF819)
B4072_RS14220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4072_RS14225	COG0626	cystathionine gamma-synthase activity
B4072_RS14230	COG0626	cystathionine gamma-synthase activity
B4072_RS14235	COG2382	esterase
B4072_RS14240	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4072_RS14245	COG2153	protein acetylation
B4072_RS14255	COG0210	DNA helicase
B4072_RS14315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B4072_RS14320	COG0351	phosphomethylpyrimidine kinase
B4072_RS14325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4072_RS14330	COG2022	thiamine diphosphate biosynthetic process
B4072_RS14335	COG2104	thiamine diphosphate biosynthetic process
B4072_RS14340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4072_RS14345	COG0352	thiamine-phosphate diphosphorylase activity
B4072_RS14350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B4072_RS14355	COG0475	glutathione-regulated potassium exporter activity
B4072_RS14355	COG0569	domain protein
B4072_RS14360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4072_RS14365	COG0564	pseudouridine synthase activity
B4072_RS14370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4072_RS14375	COG2357	RelA SpoT domain protein
B4072_RS14385	COG4116	CYTH
B4072_RS14390	COG0741	lytic transglycosylase activity
B4072_RS14395	COG2346	COG2346, Truncated hemoglobins
B4072_RS14400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4072_RS14415	COG1164	Oligoendopeptidase f
B4072_RS14420	COG4469	Competence protein
B4072_RS14425	COG4862	establishment of competence for transformation
B4072_RS14430	COG0861	Integral membrane protein TerC family
B4072_RS14435	COG1393	Belongs to the ArsC family
B4072_RS14440	COG0456	acetyltransferase
B4072_RS14445	COG2814	Major facilitator Superfamily
B4072_RS14450	COG4608	Belongs to the ABC transporter superfamily
B4072_RS14455	COG0444	Belongs to the ABC transporter superfamily
B4072_RS14460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4072_RS14465	COG0601	transmembrane transport
B4072_RS14470	COG4166	transmembrane transport
B4072_RS14475	COG0180	Tryptophanyl-tRNA synthetase
B4072_RS14480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4072_RS14485	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B4072_RS14490	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B4072_RS14500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4072_RS14505	COG4786	Flagellar basal body rod
B4072_RS14505	COG1256	bacterial-type flagellum assembly
B4072_RS14510	COG3418	PFAM FlgN family protein
B4072_RS14515	COG2747	anti-sigma28 factor FlgM
B4072_RS14525	COG1040	competence protein
B4072_RS14535	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4072_RS14540	COG1307	EDD domain protein, DegV family
B4072_RS14545	COG2197	response regulator
B4072_RS14550	COG4585	Histidine kinase
B4072_RS14555	COG1739	Uncharacterized protein family UPF0029
B4072_RS14560	COG1316	TRANSCRIPTIONal
B4072_RS14565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4072_RS14570	COG0438	transferase activity, transferring glycosyl groups
B4072_RS14575	COG1215	transferase activity, transferring glycosyl groups
B4072_RS14580	COG3206	protein involved in exopolysaccharide biosynthesis
B4072_RS14585	COG3307	-O-antigen
B4072_RS14590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4072_RS14595	COG0438	transferase activity, transferring glycosyl groups
B4072_RS14595	COG0297	glycogen (starch) synthase activity
B4072_RS14600	COG2244	polysaccharide biosynthetic process
B4072_RS14610	COG2247	cell wall binding repeat
B4072_RS14610	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4072_RS14615	COG2247	cell wall binding repeat
B4072_RS14615	COG2385	sporulation resulting in formation of a cellular spore
B4072_RS14625	COG1316	TRANSCRIPTIONal
B4072_RS14630	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4072_RS14635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4072_RS14640	COG1215	transferase activity, transferring glycosyl groups
B4072_RS14640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4072_RS14645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4072_RS14645	COG1215	transferase activity, transferring glycosyl groups
B4072_RS14650	COG0463	Glycosyl transferase, family 2
B4072_RS14665	COG1134	teichoic acid transport
B4072_RS14670	COG1682	transport, permease protein
B4072_RS14675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4072_RS14680	COG0438	transferase activity, transferring glycosyl groups
B4072_RS14685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B4072_RS14690	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B4072_RS14695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4072_RS14705	COG4193	domain, Protein
B4072_RS14710	COG1482	cell wall glycoprotein biosynthetic process
B4072_RS14720	COG0697	spore germination
B4072_RS14725	COG0814	amino acid
B4072_RS14735	COG2814	Major facilitator Superfamily
B4072_RS14740	COG1316	TRANSCRIPTIONal
B4072_RS14745	COG0561	phosphatase activity
B4072_RS14750	COG2199	diguanylate cyclase activity
B4072_RS14750	COG2203	Gaf domain
B4072_RS14755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B4072_RS14765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4072_RS14770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4072_RS14775	COG0454	-acetyltransferase
B4072_RS14780	COG0517	IMP dehydrogenase activity
B4072_RS14785	COG0123	including yeast histone deacetylase and acetoin utilization protein
B4072_RS14790	COG1360	Flagellar Motor Protein
B4072_RS14795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4072_RS14800	COG1609	Transcriptional regulator
B4072_RS14805	COG1605	Chorismate mutase
B4072_RS14805	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4072_RS14810	COG3118	belongs to the thioredoxin family
B4072_RS14815	COG4980	gas vesicle protein
B4072_RS14820	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4072_RS14825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4072_RS14830	COG1674	ftsk spoiiie
B4072_RS14835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4072_RS14840	COG4848	Belongs to the UPF0354 family
B4072_RS14845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS14855	COG1363	Peptidase, m42
B4072_RS14860	COG5584	Small secreted protein
B4072_RS14865	COG0281	malic enzyme
B4072_RS14870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4072_RS14875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B4072_RS14885	COG0510	thiamine kinase activity
B4072_RS14890	COG1523	belongs to the glycosyl hydrolase 13 family
B4072_RS14895	COG1597	lipid kinase activity
B4072_RS14905	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4072_RS14910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4072_RS14915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4072_RS14920	COG2252	PERMEase
B4072_RS14925	COG4473	ABC transporter
B4072_RS14930	COG1131	(ABC) transporter
B4072_RS14935	COG1349	DNA-binding transcription factor activity
B4072_RS14940	COG1187	pseudouridine synthase activity
B4072_RS14945	COG2244	polysaccharide biosynthetic process
B4072_RS14950	COG2081	HI0933 family
B4072_RS14955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4072_RS14965	COG5578	integral membrane protein
B4072_RS14970	COG0673	inositol 2-dehydrogenase activity
B4072_RS14975	COG1653	transport
B4072_RS14980	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B4072_RS14985	COG4209	transmembrane transport
B4072_RS14990	COG2207	Transcriptional regulator
B4072_RS14995	COG1653	transport
B4072_RS15000	COG0395	ABC-type sugar transport system, permease component
B4072_RS15005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4072_RS15010	COG2124	cytochrome p450
B4072_RS15015	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B4072_RS15025	COG0156	8-amino-7-oxononanoate synthase activity
B4072_RS15030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4072_RS15040	COG1073	alpha beta
B4072_RS15045	COG1609	Transcriptional regulator
B4072_RS15050	COG1653	transport
B4072_RS15055	COG1175	transmembrane transport
B4072_RS15060	COG0395	ABC-type sugar transport system, permease component
B4072_RS15065	COG1486	melibiose metabolic process
B4072_RS15070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4072_RS15075	COG0495	leucyl-tRNA aminoacylation
B4072_RS15085	COG1366	Belongs to the anti-sigma-factor antagonist family
B4072_RS15085	COG2202	Pas domain
B4072_RS15090	COG2814	Major facilitator Superfamily
B4072_RS15095	COG2433	Pfam Transposase IS66
B4072_RS15100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4072_RS15105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4072_RS15110	COG1396	sequence-specific DNA binding
B4072_RS15115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4072_RS15120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4072_RS15125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4072_RS15130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4072_RS15135	COG0512	Glutamine amidotransferase of anthranilate synthase
B4072_RS15140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4072_RS15145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4072_RS15150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4072_RS15155	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B4072_RS15160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B4072_RS15165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4072_RS15170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B4072_RS15175	COG0037	tRNA processing
B4072_RS15180	COG0515	serine threonine protein kinase
B4072_RS15185	COG2304	oxidoreductase activity
B4072_RS15190	COG2208	phosphoserine phosphatase activity
B4072_RS15205	COG1098	S1 RNA binding domain
B4072_RS15210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B4072_RS15225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4072_RS15230	COG3956	TIGRFAM MazG family protein
B4072_RS15235	COG2244	polysaccharide biosynthetic process
B4072_RS15240	COG2002	toxin-antitoxin pair type II binding
B4072_RS15245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4072_RS15255	COG0193	aminoacyl-tRNA hydrolase activity
B4072_RS15260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B4072_RS15265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4072_RS15270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B4072_RS15280	COG2088	sporulation resulting in formation of a cellular spore
B4072_RS15285	COG0251	oxidation-reduction process
B4072_RS15290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4072_RS15295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B4072_RS15305	COG4466	Protein conserved in bacteria
B4072_RS15315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B4072_RS15320	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4072_RS15325	COG3583	domain protein
B4072_RS15325	COG3584	3D domain protein
B4072_RS15330	COG0084	hydrolase, TatD family'
B4072_RS15335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4072_RS15335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4072_RS15340	COG2002	toxin-antitoxin pair type II binding
B4072_RS15345	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4072_RS15350	COG2827	Endonuclease containing a URI domain
B4072_RS15355	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4072_RS15360	COG4467	Involved in initiation control of chromosome replication
B4072_RS15365	COG1774	PSP1 C-terminal conserved region
B4072_RS15370	COG0470	DNA polymerase III
B4072_RS15375	COG1728	Protein conserved in bacteria
B4072_RS15380	COG3870	Protein conserved in bacteria
B4072_RS15385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4072_RS15390	COG1982	Orn Lys Arg decarboxylase major
B4072_RS15395	COG3853	Toxic anion resistance protein (TelA)
B4072_RS15400	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
B4072_RS15425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4072_RS15440	COG2323	membrane
B4072_RS15450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4072_RS15480	COG0735	belongs to the Fur family
B4072_RS15485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4072_RS15490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4072_RS15495	COG4129	membrane
B4072_RS15500	COG1132	(ABC) transporter
B4072_RS15505	COG3557	Belongs to the UPF0374 family
B4072_RS15520	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS15530	COG1194	a g-specific adenine glycosylase
B4072_RS15535	COG1988	membrane-bound metal-dependent
B4072_RS15540	COG4485	Bacterial membrane protein, YfhO
B4072_RS15545	COG0463	Glycosyl transferase, family 2
B4072_RS15550	COG0596	Alpha beta hydrolase
B4072_RS15555	COG5658	integral membrane protein
B4072_RS15560	COG3103	Sh3 type 3 domain protein
B4072_RS15565	COG0488	(ABC) transporter
B4072_RS15570	COG0513	Belongs to the DEAD box helicase family
B4072_RS15575	COG0456	acetyltransferase
B4072_RS15580	COG2130	NADP-dependent
B4072_RS15585	COG2318	DinB family
B4072_RS15595	COG1335	isochorismatase
B4072_RS15610	COG2124	cytochrome p450
B4072_RS15615	COG2732	(Barnase) inhibitor
B4072_RS15620	COG1522	sequence-specific DNA binding
B4072_RS15630	COG1687	branched-chain amino acid
B4072_RS15635	COG1114	Component of the transport system for branched-chain amino acids
B4072_RS15645	COG0583	DNA-binding transcription factor activity
B4072_RS15650	COG1942	4-Oxalocrotonate Tautomerase
B4072_RS15655	COG1230	cation diffusion facilitator family transporter
B4072_RS15660	COG2072	flavoprotein involved in K transport
B4072_RS15665	COG0583	DNA-binding transcription factor activity
B4072_RS15670	COG0697	spore germination
B4072_RS15680	COG1253	flavin adenine dinucleotide binding
B4072_RS15685	COG0456	acetyltransferase
B4072_RS15690	COG2814	Major facilitator Superfamily
B4072_RS15695	COG4978	Transcriptional regulator
B4072_RS15695	COG0789	Transcriptional regulator
B4072_RS15710	COG0662	Cupin 2, conserved barrel domain protein
B4072_RS15715	COG1937	Protein conserved in bacteria
B4072_RS15720	COG2210	Belongs to the sulfur carrier protein TusA family
B4072_RS15725	COG0425	Belongs to the sulfur carrier protein TusA family
B4072_RS15725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4072_RS15735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4072_RS15735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4072_RS15740	COG0425	Belongs to the sulfur carrier protein TusA family
B4072_RS15745	COG0730	response to heat
B4072_RS15750	COG4124	Belongs to the glycosyl hydrolase 26 family
B4072_RS15775	COG0659	secondary active sulfate transmembrane transporter activity
B4072_RS15780	COG0385	Bile acid
B4072_RS15785	COG2819	hydrolase of the alpha beta superfamily
B4072_RS15790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS15795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS15800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4072_RS15805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4072_RS15805	COG2207	Transcriptional regulator
B4072_RS15810	COG3876	Protein conserved in bacteria
B4072_RS15815	COG1472	Belongs to the glycosyl hydrolase 3 family
B4072_RS15820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4072_RS15825	COG1263	PTS System
B4072_RS15825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4072_RS15830	COG1737	Transcriptional regulator
B4072_RS15835	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B4072_RS15840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4072_RS15845	COG1683	Conserved Protein
B4072_RS15875	COG1595	DNA-templated transcription, initiation
B4072_RS15880	COG5662	AntiSigma factor
B4072_RS15885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4072_RS15890	COG4856	YbbR-like protein
B4072_RS15895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4072_RS15900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4072_RS15905	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4072_RS15915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4072_RS15920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4072_RS15925	COG3002	Belongs to the UPF0753 family
B4072_RS15930	COG0288	reversible hydration of carbon dioxide
B4072_RS15940	COG5609	conserved protein (DUF2294)
B4072_RS15950	COG0640	Transcriptional regulator
B4072_RS15955	COG2814	Major facilitator Superfamily
B4072_RS15970	COG0535	radical SAM domain protein
B4072_RS15975	COG1266	CAAX protease self-immunity
B4072_RS15980	COG1131	(ABC) transporter
B4072_RS15990	COG1413	lyase activity
B4072_RS15995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS16000	COG0596	Alpha beta hydrolase
B4072_RS16005	COG0745	RESPONSE REGULATOR receiver
B4072_RS16010	COG0642	Histidine kinase
B4072_RS16020	COG0515	serine threonine protein kinase
B4072_RS16035	COG1113	amino acid transport
B4072_RS16050	COG2602	Beta-lactamase
B4072_RS16055	COG2124	cytochrome p450
B4072_RS16065	COG0531	amino acid
B4072_RS16070	COG0584	glycerophosphoryl diester phosphodiesterase
B4072_RS16075	COG2271	Major facilitator Superfamily
B4072_RS16085	COG0456	acetyltransferase
B4072_RS16085	COG1846	Transcriptional regulator
B4072_RS16090	COG2271	Major facilitator Superfamily
B4072_RS16100	COG3409	Peptidoglycan-binding domain 1 protein
B4072_RS16105	COG0697	spore germination
B4072_RS16110	COG1917	Cupin 2, conserved barrel domain protein
B4072_RS16110	COG2207	Transcriptional regulator
B4072_RS16115	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B4072_RS16120	COG3591	Belongs to the peptidase S1B family
B4072_RS16130	COG0596	Alpha beta hydrolase
B4072_RS16135	COG1183	phosphatidylcholine synthase activity
B4072_RS16140	COG0586	Pfam SNARE associated Golgi protein
B4072_RS16145	COG0688	phosphatidylethanolamine metabolic process
B4072_RS16155	COG2312	Erythromycin esterase
B4072_RS16160	COG1054	Belongs to the UPF0176 family
B4072_RS16165	COG1301	dicarboxylic acid transport
B4072_RS16170	COG2190	(PTS) system
B4072_RS16170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4072_RS16170	COG1263	PTS System
B4072_RS16175	COG0363	glucosamine-6-phosphate deaminase activity
B4072_RS16180	COG2188	Transcriptional regulator
B4072_RS16190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4072_RS16195	COG0833	amino acid
B4072_RS16200	COG2040	homocysteine
B4072_RS16210	COG1115	amino acid carrier protein
B4072_RS16215	COG2066	Belongs to the glutaminase family
B4072_RS16220	COG4191	Histidine kinase
B4072_RS16225	COG0784	Response regulator, receiver
B4072_RS16230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4072_RS16235	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS16240	COG2271	Major facilitator Superfamily
B4072_RS16245	COG4948	Mandelate Racemase Muconate Lactonizing
B4072_RS16250	COG2186	Transcriptional regulator
B4072_RS16270	COG0697	spore germination
B4072_RS16275	COG0745	RESPONSE REGULATOR receiver
B4072_RS16285	COG1131	(ABC) transporter
B4072_RS16305	COG3773	Cell wall hydrolase
B4072_RS16310	COG2304	oxidoreductase activity
B4072_RS16320	COG3540	Alkaline phosphatase
B4072_RS16325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4072_RS16330	COG0805	protein transport
B4072_RS16335	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B4072_RS16340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4072_RS16345	COG0477	Major facilitator Superfamily
B4072_RS16350	COG1309	transcriptional regulator
B4072_RS16355	COG0252	asparaginase activity
B4072_RS16360	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B4072_RS16365	COG1714	RDD family
B4072_RS16370	COG1405	negative regulation of cell septum assembly
B4072_RS16370	COG3012	SEC-C Motif Domain Protein
B4072_RS16380	COG3279	Response regulator of the LytR AlgR family
B4072_RS16385	COG4555	ABC transporter
B4072_RS16390	COG1668	transmembrane transport
B4072_RS16395	COG0667	Aldo Keto reductase
B4072_RS16405	COG1595	DNA-templated transcription, initiation
B4072_RS16410	COG1595	DNA-templated transcription, initiation
B4072_RS16415	COG1876	peptidase activity
B4072_RS16420	COG0457	Tetratricopeptide repeat
B4072_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS16430	COG0366	Alpha amylase catalytic
B4072_RS16435	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4072_RS16440	COG1121	(ABC) transporter
B4072_RS16445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4072_RS16450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4072_RS16455	COG2310	stress, protein
B4072_RS16460	COG2310	stress, protein
B4072_RS16465	COG2310	stress, protein
B4072_RS16470	COG0861	Integral membrane protein TerC family
B4072_RS16480	COG3853	Toxic anion resistance protein (TelA)
B4072_RS16485	COG0477	Major facilitator Superfamily
B4072_RS16490	COG2814	Major facilitator Superfamily
B4072_RS16495	COG0640	Transcriptional regulator
B4072_RS16500	COG4175	Glycine betaine
B4072_RS16500	COG0517	IMP dehydrogenase activity
B4072_RS16505	COG4176	ABC-type proline glycine betaine transport system permease component
B4072_RS16510	COG2113	Glycine betaine
B4072_RS16515	COG1473	amidohydrolase
B4072_RS16520	COG1288	antiporter activity
B4072_RS16540	COG0039	L-malate dehydrogenase activity
B4072_RS16545	COG1620	l-lactate permease
B4072_RS16550	COG3403	YqcI/YcgG family
B4072_RS16565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4072_RS16570	COG1660	Displays ATPase and GTPase activities
B4072_RS16575	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B4072_RS16580	COG2226	methyltransferase
B4072_RS16585	COG0583	DNA-binding transcription factor activity
B4072_RS16590	COG3458	cephalosporin-C deacetylase activity
B4072_RS16595	COG3541	Predicted nucleotidyltransferase
B4072_RS16600	COG0506	proline dehydrogenase activity
B4072_RS16605	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS16610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4072_RS16615	COG2508	Transcriptional regulator
B4072_RS16620	COG0569	domain protein
B4072_RS16625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4072_RS16630	COG4682	membrane
B4072_RS16635	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4072_RS16640	COG0477	Major facilitator Superfamily
B4072_RS16645	COG5553	Cysteine dioxygenase type I
B4072_RS16655	COG1968	undecaprenyl-diphosphatase activity
B4072_RS16660	COG0628	permease
B4072_RS16665	COG0673	inositol 2-dehydrogenase activity
B4072_RS16670	COG4806	L-rhamnose isomerase
B4072_RS16675	COG3254	rhamnose metabolic process
B4072_RS16680	COG1070	Carbohydrate kinase
B4072_RS16685	COG1349	DNA-binding transcription factor activity
B4072_RS16690	COG3347	Dehydrogenase
B4072_RS16690	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS16700	COG0840	transmembrane signaling receptor activity
B4072_RS16705	COG0840	transmembrane signaling receptor activity
B4072_RS16715	COG0840	transmembrane signaling receptor activity
B4072_RS16730	COG0432	Pfam Uncharacterised protein family UPF0047
B4072_RS16735	COG0366	Alpha amylase catalytic
B4072_RS16740	COG1253	flavin adenine dinucleotide binding
B4072_RS16745	COG2738	Putative neutral zinc metallopeptidase
B4072_RS16760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4072_RS16775	COG0166	Belongs to the GPI family
B4072_RS16780	COG1979	alcohol dehydrogenase
B4072_RS16785	COG1979	alcohol dehydrogenase
B4072_RS16790	COG2155	Conserved Protein
B4072_RS16795	COG1098	S1 RNA binding domain
B4072_RS16800	COG0436	Aminotransferase
B4072_RS16805	COG1522	sequence-specific DNA binding
B4072_RS16810	COG2267	carboxylic ester hydrolase activity
B4072_RS16820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B4072_RS16825	COG2205	protein histidine kinase activity
B4072_RS16835	COG5018	Exonuclease
B4072_RS16845	COG2814	Major facilitator Superfamily
B4072_RS16850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4072_RS16855	COG3011	Protein conserved in bacteria
B4072_RS16865	COG3290	protein histidine kinase activity
B4072_RS16870	COG4565	transcriptional regulatory protein
B4072_RS16875	COG1744	ABC transporter substrate-binding protein PnrA-like
B4072_RS16880	COG3845	ABC transporter
B4072_RS16885	COG4603	Belongs to the binding-protein-dependent transport system permease family
B4072_RS16890	COG1079	Belongs to the binding-protein-dependent transport system permease family
B4072_RS16895	COG3493	citrate carrier protein
B4072_RS16905	COG2111	Na H antiporter
B4072_RS16905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4072_RS16910	COG2111	Na H antiporter
B4072_RS16915	COG1006	Multisubunit Na H antiporter MnhC subunit
B4072_RS16920	COG0651	ATP synthesis coupled electron transport
B4072_RS16925	COG1863	multisubunit Na H antiporter MnhE subunit
B4072_RS16930	COG2212	antiporter activity
B4072_RS16935	COG1320	monovalent cation:proton antiporter activity
B4072_RS16940	COG2050	protein possibly involved in aromatic compounds catabolism
B4072_RS16945	COG2197	response regulator
B4072_RS16950	COG4585	Histidine kinase
B4072_RS16960	COG0142	geranyltranstransferase activity
B4072_RS16975	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B4072_RS16980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B4072_RS16985	COG1335	isochorismatase
B4072_RS16990	COG5506	Protein of unknown function (DUF1694)
B4072_RS17005	COG0628	permease
B4072_RS17020	COG1418	mRNA catabolic process
B4072_RS17025	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS17035	COG1511	domain protein
B4072_RS17040	COG0433	COG0433 Predicted ATPase
B4072_RS17040	COG1674	ftsk spoiiie
B4072_RS17045	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4072_RS17050	COG5417	Belongs to the EsaB family
B4072_RS17055	COG4842	Belongs to the WXG100 family
B4072_RS17060	COG2508	Transcriptional regulator
B4072_RS17060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B4072_RS17065	COG0686	Belongs to the AlaDH PNT family
B4072_RS17070	COG5634	Uncharacterized conserved protein (DUF2278)
B4072_RS17075	COG3251	PFAM MbtH domain protein
B4072_RS17080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4072_RS17085	COG3433	isochorismatase activity
B4072_RS17085	COG1535	isochorismatase
B4072_RS17090	COG1021	2,3-dihydroxybenzoate-AMP ligase
B4072_RS17095	COG1169	isochorismate synthase
B4072_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS17105	COG2819	hydrolase of the alpha beta superfamily
B4072_RS17110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4072_RS17115	COG1268	BioY protein
B4072_RS17120	COG2056	Na+-H+ antiporter family
B4072_RS17125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4072_RS17130	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B4072_RS17135	COG3584	3D domain protein
B4072_RS17150	COG1252	NADH dehydrogenase
B4072_RS17155	COG0492	ferredoxin-NADP+ reductase activity
B4072_RS17165	COG0516	GMP reductase activity
B4072_RS17170	COG2808	Putative FMN-binding domain
B4072_RS17180	COG0316	Belongs to the HesB IscA family
B4072_RS17185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B4072_RS17190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4072_RS17195	COG4844	belongs to the
B4072_RS17200	COG1252	NADH dehydrogenase
B4072_RS17205	COG4837	Protein of unknown function (DUF1462)
B4072_RS17210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4072_RS17215	COG0823	Involved in the tonB-independent uptake of proteins
B4072_RS17215	COG1506	peptidase
B4072_RS17215	COG4946	Tricorn protease homolog
B4072_RS17220	COG0083	homoserine kinase activity
B4072_RS17225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4072_RS17230	COG0460	homoserine dehydrogenase
B4072_RS17235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4072_RS17240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4072_RS17245	COG0647	UMP catabolic process
B4072_RS17250	COG2445	Protein of unknown function DUF86
B4072_RS17255	COG4470	Protein conserved in bacteria
B4072_RS17265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B4072_RS17270	COG0739	heme binding
B4072_RS17280	COG3377	Domain of unknown function (DUF1805)
B4072_RS17285	COG0737	Belongs to the 5'-nucleotidase family
B4072_RS17290	COG0730	response to heat
B4072_RS17295	COG1801	Protein of unknown function DUF72
B4072_RS17305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4072_RS17310	COG2508	Transcriptional regulator
B4072_RS17315	COG2233	PERMEase
B4072_RS17320	COG2233	PERMEase
B4072_RS17325	COG3195	allantoin biosynthetic process
B4072_RS17325	COG3648	Uricase
B4072_RS17330	COG2351	hydroxyisourate hydrolase activity
B4072_RS17340	COG2080	2 iron, 2 sulfur cluster binding
B4072_RS17345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B4072_RS17350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B4072_RS17355	COG2068	MobA-Related Protein
B4072_RS17360	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B4072_RS17365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4072_RS17370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4072_RS17380	COG2356	endonuclease I
B4072_RS17395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4072_RS17405	COG0072	phenylalanine-tRNA ligase activity
B4072_RS17405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4072_RS17420	COG3842	ATPase activity
B4072_RS17425	COG2188	Transcriptional regulator
B4072_RS17430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4072_RS17445	COG2222	sugar isomerase
B4072_RS17450	COG0322	excinuclease ABC activity
B4072_RS17455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4072_RS17480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4072_RS17505	COG1525	nuclease
B4072_RS17510	COG2814	Major facilitator Superfamily
B4072_RS17515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4072_RS17525	COG0756	dUTP diphosphatase activity
B4072_RS17565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4072_RS17580	COG3832	glyoxalase III activity
B4072_RS17595	COG0697	spore germination
B4072_RS17600	COG0531	amino acid
B4072_RS17630	COG4195	phage-related replication protein
B4072_RS17640	COG0346	lactoylglutathione lyase activity
B4072_RS17650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4072_RS17655	COG1388	LysM domain
B4072_RS17660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4072_RS17665	COG4224	UPF0291 protein
B4072_RS17670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B4072_RS17680	COG3763	UPF0154 protein
B4072_RS17690	COG0785	Cytochrome C biogenesis protein
B4072_RS17695	COG2201	protein-glutamate methylesterase activity
B4072_RS17700	COG4846	Membrane protein involved in cytochrome C biogenesis
B4072_RS17710	COG3859	Proton-coupled thiamine transporter YuaJ
B4072_RS17715	COG1247	-acetyltransferase
B4072_RS17720	COG2268	Band 7 protein
B4072_RS17725	COG1585	Membrane protein implicated in regulation of membrane protease activity
B4072_RS17730	COG2318	DinB family
B4072_RS17740	COG1454	alcohol dehydrogenase
B4072_RS17745	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS17750	COG1510	regulation of RNA biosynthetic process
B4072_RS17830	COG1160	GTP binding
B4072_RS17835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B4072_RS17850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4072_RS17855	COG0776	regulation of translation
B4072_RS17860	COG0302	gtp cyclohydrolase
B4072_RS17870	COG0142	geranyltranstransferase activity
B4072_RS17875	COG2226	methyltransferase
B4072_RS17880	COG0142	geranyltranstransferase activity
B4072_RS17885	COG0105	UTP biosynthetic process
B4072_RS17895	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4072_RS17900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B4072_RS17905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B4072_RS17910	COG4401	Chorismate mutase type I
B4072_RS17915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4072_RS17920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4072_RS17930	COG0135	phosphoribosylanthranilate isomerase activity
B4072_RS17935	COG0133	tryptophan synthase activity
B4072_RS17940	COG0159	tryptophan synthase activity
B4072_RS17950	COG0287	Prephenate dehydrogenase
B4072_RS17955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4072_RS17960	COG0457	Tetratricopeptide repeat
B4072_RS17965	COG5582	Belongs to the UPF0302 family
B4072_RS17975	COG0723	plastoquinol--plastocyanin reductase activity
B4072_RS17980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4072_RS17985	COG2010	Cytochrome c
B4072_RS17985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4072_RS17990	COG4347	Protein of unknown function (DUF1405)
B4072_RS18000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4072_RS18005	COG1694	Mazg nucleotide pyrophosphohydrolase
B4072_RS18010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B4072_RS18015	COG1803	Methylglyoxal synthase
B4072_RS18020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4072_RS18025	COG0438	transferase activity, transferring glycosyl groups
B4072_RS18030	COG0617	tRNA 3'-terminal CCA addition
B4072_RS18035	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B4072_RS18035	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B4072_RS18040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B4072_RS18045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B4072_RS18050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B4072_RS18055	COG1199	ATP-dependent helicase activity
B4072_RS18055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4072_RS18065	COG5353	protein conserved in bacteria
B4072_RS18070	COG0436	Aminotransferase
B4072_RS18075	COG0017	Asparaginyl-tRNA synthetase
B4072_RS18080	COG3935	DnaD domain protein
B4072_RS18085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4072_RS18095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4072_RS18095	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4072_RS18100	COG3331	DNA recombination
B4072_RS18135	COG0071	Belongs to the small heat shock protein (HSP20) family
B4072_RS18140	COG2190	(PTS) system
B4072_RS18145	COG1205	dead DEAH box helicase
B4072_RS18145	COG1111	helicase
B4072_RS18150	COG3359	exonuclease
B4072_RS18160	COG4474	Belongs to the UPF0398 family
B4072_RS18170	COG0116	Belongs to the methyltransferase superfamily
B4072_RS18180	COG1199	ATP-dependent helicase activity
B4072_RS18185	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS18190	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B4072_RS18195	COG1609	Transcriptional regulator
B4072_RS18200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4072_RS18205	COG0800	Aldolase
B4072_RS18215	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B4072_RS18220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4072_RS18225	COG2233	PERMEase
B4072_RS18230	COG3424	synthase
B4072_RS18235	COG1755	Isoprenylcysteine carboxyl methyltransferase
B4072_RS18240	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4072_RS18260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4072_RS18270	COG0328	RNA-DNA hybrid ribonuclease activity
B4072_RS18275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4072_RS18280	COG0328	RNA-DNA hybrid ribonuclease activity
B4072_RS18300	COG1278	Cold shock
B4072_RS18305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4072_RS18310	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B4072_RS18315	COG0386	Belongs to the glutathione peroxidase family
B4072_RS18325	COG1413	lyase activity
B4072_RS18330	COG0129	dihydroxy-acid dehydratase activity
B4072_RS18340	COG2136	Putative SAM-dependent methyltransferase
B4072_RS18340	COG2521	methyltransferase
B4072_RS18350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4072_RS18355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B4072_RS18360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4072_RS18365	COG0204	Acyl-transferase
B4072_RS18370	COG1272	protein, Hemolysin III
B4072_RS18375	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B4072_RS18380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4072_RS18395	COG1999	signal sequence binding
B4072_RS18400	COG2755	lipolytic protein G-D-S-L family
B4072_RS18405	COG4698	Protein conserved in bacteria
B4072_RS18415	COG0534	Mate efflux family protein
B4072_RS18420	COG1846	Transcriptional regulator
B4072_RS18425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4072_RS18430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4072_RS18435	COG1086	Polysaccharide biosynthesis protein
B4072_RS18440	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B4072_RS18445	COG4641	Protein conserved in bacteria
B4072_RS18460	COG0463	Glycosyl transferase, family 2
B4072_RS18465	COG0456	acetyltransferase
B4072_RS18480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4072_RS18485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4072_RS18490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4072_RS18495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4072_RS18500	COG0456	acetyltransferase
B4072_RS18505	COG1509	lysine 2,3-aminomutase activity
B4072_RS18515	COG4479	Belongs to the UPF0346 family
B4072_RS18540	COG0671	phosphoesterase, PA-phosphatase related
B4072_RS18555	COG0813	purine-nucleoside phosphorylase activity
B4072_RS18560	COG1876	peptidase activity
B4072_RS18570	COG2226	methyltransferase
B4072_RS18575	COG3409	Peptidoglycan-binding domain 1 protein
B4072_RS18575	COG0793	Belongs to the peptidase S41A family
B4072_RS18580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4072_RS18590	COG0346	lactoylglutathione lyase activity
B4072_RS18595	COG0400	carboxylic ester hydrolase activity
B4072_RS18605	COG0823	Involved in the tonB-independent uptake of proteins
B4072_RS18610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B4072_RS18615	COG1063	alcohol dehydrogenase
B4072_RS18620	COG2814	Major facilitator Superfamily
B4072_RS18630	COG4260	virion core protein, lumpy skin disease virus
B4072_RS18635	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B4072_RS18640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4072_RS18645	COG1842	Phage shock protein A
B4072_RS18650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4072_RS18655	COG2211	Major facilitator Superfamily
B4072_RS18660	COG1063	alcohol dehydrogenase
B4072_RS18690	COG0459	protein refolding
B4072_RS18700	COG1266	CAAX protease self-immunity
B4072_RS18710	COG0805	protein transport
B4072_RS18715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4072_RS18720	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B4072_RS18725	COG0315	cyclic pyranopterin monophosphate synthase activity
B4072_RS18730	COG0488	(ABC) transporter
B4072_RS18735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B4072_RS18740	COG0456	acetyltransferase
B4072_RS18745	COG1214	PFAM Peptidase M22, glycoprotease
B4072_RS18750	COG0802	atpase or kinase
B4072_RS18755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B4072_RS18775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4072_RS18790	COG0753	catalase activity
B4072_RS18790	COG0693	protein deglycase activity
B4072_RS18795	COG2851	Citrate transporter
B4072_RS18800	COG2273	Hydrolase Family 16
B4072_RS18815	COG2270	Major facilitator Superfamily
B4072_RS18820	COG0513	Belongs to the DEAD box helicase family
B4072_RS18825	COG2755	lipolytic protein G-D-S-L family
B4072_RS18825	COG3401	FG-GAP repeat protein
B4072_RS18870	COG0791	NLP P60 protein
B4072_RS18880	COG2843	Capsule synthesis protein
B4072_RS18890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4072_RS18895	COG1609	Transcriptional regulator
B4072_RS18900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4072_RS18905	COG1869	D-ribose catabolic process
B4072_RS18910	COG1129	ABC transporter
B4072_RS18915	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4072_RS18920	COG1879	ABC-type sugar transport system periplasmic component
B4072_RS18925	COG3103	Sh3 type 3 domain protein
B4072_RS18935	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4072_RS18940	COG3527	Alpha-acetolactate decarboxylase
B4072_RS18945	COG0028	Belongs to the TPP enzyme family
B4072_RS18950	COG0583	DNA-binding transcription factor activity
B4072_RS18970	COG5337	Spore coat protein CotH
B4072_RS18980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4072_RS18990	COG0405	Gamma-glutamyltransferase
B4072_RS18995	COG1522	sequence-specific DNA binding
B4072_RS19000	COG2059	Chromate
B4072_RS19005	COG2059	Chromate
B4072_RS19015	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4072_RS19020	COG0583	DNA-binding transcription factor activity
B4072_RS19035	COG5444	nuclease activity
B4072_RS19055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4072_RS19060	COG4464	protein tyrosine phosphatase activity
B4072_RS19065	COG0489	protein tyrosine kinase activity
B4072_RS19070	COG3944	biosynthesis protein
B4072_RS19080	COG4715	Zinc finger, swim domain protein
B4072_RS19085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4072_RS19090	COG0561	phosphatase activity
B4072_RS19095	COG1349	DNA-binding transcription factor activity
B4072_RS19100	COG0629	single-stranded DNA binding
B4072_RS19115	COG3764	Sortase (surface protein transpeptidase)
B4072_RS19120	COG2972	Histidine kinase
B4072_RS19120	COG0745	RESPONSE REGULATOR receiver
B4072_RS19125	COG1970	mechanosensitive ion channel activity
B4072_RS19130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4072_RS19135	COG0457	Tetratricopeptide repeat
B4072_RS19140	COG4786	Flagellar basal body rod
B4072_RS19145	COG4786	Flagellar basal body rod
B4072_RS19150	COG1077	Cell shape determining protein MreB Mrl
B4072_RS19155	COG1609	Transcriptional regulator
B4072_RS19160	COG1846	Transcriptional regulator
B4072_RS19165	COG2814	Major facilitator Superfamily
B4072_RS19180	COG0477	Major facilitator Superfamily
B4072_RS19185	COG1335	isochorismatase
B4072_RS19195	COG0004	ammonium transporteR
B4072_RS19200	COG0347	Belongs to the P(II) protein family
B4072_RS19205	COG0671	phosphoesterase, PA-phosphatase related
B4072_RS19220	COG2070	2-Nitropropane dioxygenase
B4072_RS19225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B4072_RS19260	COG0561	phosphatase activity
B4072_RS19265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B4072_RS19270	COG1914	H( )-stimulated, divalent metal cation uptake system
B4072_RS19275	COG4336	lyase activity
B4072_RS19280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4072_RS19285	COG1984	allophanate hydrolase subunit 2
B4072_RS19290	COG1414	Transcriptional regulator
B4072_RS19295	COG2755	lipolytic protein G-D-S-L family
B4072_RS19310	COG0768	penicillin binding
B4072_RS19315	COG4989	oxidoreductase activity
B4072_RS19320	COG3711	transcriptional antiterminator
B4072_RS19325	COG0318	PFAM AMP-dependent synthetase and ligase
B4072_RS19330	COG2226	methyltransferase
B4072_RS19335	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS19340	COG1917	Cupin 2, conserved barrel domain protein
B4072_RS19345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4072_RS19350	COG3871	stress protein (general stress protein 26)
B4072_RS19360	COG2814	Major facilitator Superfamily
B4072_RS19365	COG1522	sequence-specific DNA binding
B4072_RS19370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4072_RS19370	COG0551	DNA topoisomerase type I activity
B4072_RS19375	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B4072_RS19390	COG1215	transferase activity, transferring glycosyl groups
B4072_RS19400	COG0531	amino acid
B4072_RS19405	COG0494	nUDIX hydrolase
B4072_RS19410	COG0028	Belongs to the TPP enzyme family
B4072_RS19425	COG1914	H( )-stimulated, divalent metal cation uptake system
B4072_RS19430	COG2261	transglycosylase associated protein
B4072_RS19435	COG4876	unkown
B4072_RS19440	COG2217	Heavy metal translocating P-type atpase
B4072_RS19445	COG3729	General stress protein
B4072_RS19450	COG0662	Cupin 2, conserved barrel domain protein
B4072_RS19455	COG2329	Antibiotic biosynthesis monooxygenase
B4072_RS19465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B4072_RS19470	COG3290	protein histidine kinase activity
B4072_RS19475	COG4565	transcriptional regulatory protein
B4072_RS19480	COG1301	dicarboxylic acid transport
B4072_RS19485	COG0628	permease
B4072_RS19495	COG1131	(ABC) transporter
B4072_RS19500	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4072_RS19510	COG1960	acyl-CoA dehydrogenase activity
B4072_RS19525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4072_RS19530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4072_RS19535	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4072_RS19540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4072_RS19545	COG0513	Belongs to the DEAD box helicase family
B4072_RS19550	COG3402	PFAM membrane-flanked domain
B4072_RS19555	COG3428	Bacterial PH domain
B4072_RS19560	COG0705	Rhomboid family
B4072_RS19565	COG0736	holo-[acyl-carrier-protein] synthase activity
B4072_RS19570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B4072_RS19575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4072_RS19580	COG0864	Transcriptional regulator
B4072_RS19585	COG2337	Toxic component of a toxin-antitoxin (TA) module
B4072_RS19590	COG1366	Belongs to the anti-sigma-factor antagonist family
B4072_RS19595	COG1366	Belongs to the anti-sigma-factor antagonist family
B4072_RS19600	COG2172	sigma factor antagonist activity
B4072_RS19605	COG2208	phosphoserine phosphatase activity
B4072_RS19610	COG1366	Belongs to the anti-sigma-factor antagonist family
B4072_RS19615	COG2172	sigma factor antagonist activity
B4072_RS19620	COG1191	sigma factor activity
B4072_RS19625	COG2208	phosphoserine phosphatase activity
B4072_RS19630	COG2183	response to ionizing radiation
B4072_RS19640	COG3091	SprT-like family
B4072_RS19670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4072_RS19675	COG0601	transmembrane transport
B4072_RS19685	COG4608	Belongs to the ABC transporter superfamily
B4072_RS19690	COG0444	Belongs to the ABC transporter superfamily
B4072_RS19695	COG5504	Zn-dependent protease
B4072_RS19700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4072_RS19705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4072_RS19720	COG1744	ABC transporter substrate-binding protein PnrA-like
B4072_RS19730	COG2267	carboxylic ester hydrolase activity
B4072_RS19745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4072_RS19750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4072_RS19755	COG0505	Belongs to the CarA family
B4072_RS19760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4072_RS19770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B4072_RS19775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B4072_RS19780	COG2271	Major facilitator Superfamily
B4072_RS19785	COG0277	FAD linked oxidase domain protein
B4072_RS19795	COG2151	metal-sulfur cluster biosynthetic enzyme
B4072_RS19800	COG1073	alpha beta
B4072_RS19805	COG0561	phosphatase activity
B4072_RS19825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4072_RS19830	COG1307	EDD domain protein, DegV family
B4072_RS19835	COG3227	Zinc metalloprotease (Elastase)
B4072_RS19850	COG1695	Transcriptional regulator
B4072_RS19870	COG2996	Protein conserved in bacteria
B4072_RS19875	COG1666	GTP binding
B4072_RS19885	COG2153	protein acetylation
B4072_RS19890	COG0454	-acetyltransferase
B4072_RS19930	COG3689	TIGRFAM TIGR03943 family protein
B4072_RS19935	COG0701	Predicted permease
B4072_RS19940	COG2267	carboxylic ester hydrolase activity
B4072_RS19945	COG0492	ferredoxin-NADP+ reductase activity
B4072_RS19950	COG1587	Uroporphyrinogen-III synthase
B4072_RS19950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4072_RS19955	COG2146	nitrite reductase [NAD(P)H] activity
B4072_RS19960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4072_RS19965	COG0243	molybdopterin cofactor binding
B4072_RS19970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4072_RS19975	COG2223	nitrite transmembrane transporter activity
B4072_RS19980	COG1469	GTP cyclohydrolase I activity
B4072_RS19985	COG1376	ErfK ybiS ycfS ynhG family protein
B4072_RS20000	COG0765	amino acid transport
B4072_RS20005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4072_RS20015	COG1714	RDD family
B4072_RS20025	COG2723	6-phospho-beta-galactosidase activity
B4072_RS20035	COG3209	COG3209 Rhs family protein
B4072_RS20040	COG0840	transmembrane signaling receptor activity
B4072_RS20040	COG3290	protein histidine kinase activity
B4072_RS20045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B4072_RS20050	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B4072_RS20055	COG1733	regulation of RNA biosynthetic process
B4072_RS20065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4072_RS20070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4072_RS20075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4072_RS20080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4072_RS20085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4072_RS20090	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B4072_RS20105	COG0697	spore germination
B4072_RS20110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4072_RS20120	COG2364	Membrane
B4072_RS20125	COG1126	abc transporter atp-binding protein
B4072_RS20130	COG0765	amino acid transport
B4072_RS20135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4072_RS20140	COG0583	DNA-binding transcription factor activity
B4072_RS20145	COG0163	prenyltransferase activity
B4072_RS20150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B4072_RS20165	COG0596	Alpha beta hydrolase
B4072_RS20170	COG3104	oligopeptide transport
B4072_RS20175	COG5434	Belongs to the glycosyl hydrolase 28 family
B4072_RS20185	COG0697	spore germination
B4072_RS20195	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4072_RS20200	COG1136	(ABC) transporter
B4072_RS20205	COG0577	efflux transmembrane transporter activity
B4072_RS20210	COG0745	RESPONSE REGULATOR receiver
B4072_RS20215	COG3850	Histidine kinase
B4072_RS20215	COG5002	protein histidine kinase activity
B4072_RS20220	COG0457	Tetratricopeptide repeat
B4072_RS20240	COG0527	aspartate kinase activity
B4072_RS20245	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4072_RS20250	COG4605	iron ion homeostasis
B4072_RS20255	COG4604	ABC transporter, ATP-binding protein
B4072_RS20260	COG4607	ABC-type enterochelin transport system periplasmic component
B4072_RS20265	COG2814	Major facilitator Superfamily
B4072_RS20270	COG1309	transcriptional regulator
B4072_RS20275	COG0778	Nitroreductase
B4072_RS20280	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B4072_RS20285	COG0640	Transcriptional regulator
B4072_RS20290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4072_RS20295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B4072_RS20300	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS20305	COG4975	Glucose uptake
B4072_RS20310	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS20315	COG4549	nuclear export factor GLE1
B4072_RS20325	COG1349	DNA-binding transcription factor activity
B4072_RS20335	COG2213	PTS system mannitol-specific
B4072_RS20340	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4072_RS20345	COG0246	Mannitol dehydrogenase
B4072_RS20350	COG0473	3-isopropylmalate dehydrogenase activity
B4072_RS20355	COG0681	Belongs to the peptidase S26 family
B4072_RS20365	COG0412	Dienelactone hydrolase
B4072_RS20370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4072_RS20375	COG2814	Major facilitator Superfamily
B4072_RS20380	COG0326	Molecular chaperone. Has ATPase activity
B4072_RS20390	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS20395	COG1309	transcriptional regulator
B4072_RS20400	COG1012	belongs to the aldehyde dehydrogenase family
B4072_RS20410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4072_RS20420	COG1714	RDD family
B4072_RS20425	COG2311	Membrane
B4072_RS20430	COG1917	Cupin 2, conserved barrel domain protein
B4072_RS20435	COG1309	transcriptional regulator
B4072_RS20440	COG1028	Short-chain dehydrogenase reductase Sdr
B4072_RS20445	COG1846	Transcriptional regulator
B4072_RS20450	COG1380	Effector of murein hydrolase LrgA
B4072_RS20455	COG1346	cytolysis
B4072_RS20460	COG5039	Polysaccharide pyruvyl transferase
B4072_RS20465	COG1929	Belongs to the glycerate kinase type-1 family
B4072_RS20470	COG1802	Transcriptional regulator
B4072_RS20475	COG1070	Carbohydrate kinase
B4072_RS20480	COG2610	gluconate transmembrane transporter activity
B4072_RS20485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4072_RS20490	COG0450	alkyl hydroperoxide reductase
B4072_RS20495	COG3634	alkyl hydroperoxide reductase activity
B4072_RS20500	COG2723	6-phospho-beta-galactosidase activity
B4072_RS20510	COG2188	Transcriptional regulator
B4072_RS20525	COG1131	(ABC) transporter
B4072_RS20530	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
B4072_RS20540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4072_RS20545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B4072_RS20555	COG1063	alcohol dehydrogenase
B4072_RS20575	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
B4072_RS20580	COG0456	acetyltransferase
B4072_RS20585	COG0457	Tetratricopeptide repeat
B4072_RS20595	COG0010	Belongs to the arginase family
B4072_RS20600	COG0833	amino acid
B4072_RS20605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4072_RS20610	COG3829	transcription factor binding
B4072_RS20615	COG5002	protein histidine kinase activity
B4072_RS20620	COG0745	RESPONSE REGULATOR receiver
B4072_RS20640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4072_RS20645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4072_RS20650	COG4853	Protein conserved in bacteria
B4072_RS20655	COG4863	YycH protein
B4072_RS20660	COG5002	protein histidine kinase activity
B4072_RS20665	COG0745	RESPONSE REGULATOR receiver
B4072_RS20690	COG0346	lactoylglutathione lyase activity
B4072_RS20695	COG0305	Participates in initiation and elongation during chromosome replication
B4072_RS20715	COG3093	addiction module antidote protein HigA
B4072_RS20720	COG2807	transmembrane transport
B4072_RS20730	COG0359	binds to the 23S rRNA
B4072_RS20735	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B4072_RS20740	COG4241	membrane
B4072_RS20755	COG1733	regulation of RNA biosynthetic process
B4072_RS20760	COG1227	inorganic diphosphatase activity
B4072_RS20775	COG2271	Major facilitator Superfamily
B4072_RS20780	COG0789	Transcriptional regulator
B4072_RS20780	COG4978	Transcriptional regulator
B4072_RS20790	COG4319	ketosteroid isomerase
B4072_RS20795	COG1357	PFAM Pentapeptide repeats (8 copies)
B4072_RS20800	COG2814	Major facilitator Superfamily
B4072_RS20805	COG0583	DNA-binding transcription factor activity
B4072_RS20810	COG2153	protein acetylation
B4072_RS20820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4072_RS20825	COG1846	Transcriptional regulator
B4072_RS20830	COG2153	protein acetylation
B4072_RS20835	COG2364	Membrane
B4072_RS20840	COG0456	acetyltransferase
B4072_RS20860	COG1266	CAAX protease self-immunity
B4072_RS20865	COG2814	Major facilitator Superfamily
B4072_RS20865	COG0477	Major facilitator Superfamily
B4072_RS20870	COG0110	maltose O-acetyltransferase activity
B4072_RS20875	COG0346	lactoylglutathione lyase activity
B4072_RS20880	COG1609	Transcriptional regulator
B4072_RS20885	COG0708	Exodeoxyribonuclease III
B4072_RS20890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B4072_RS20895	COG0629	single-stranded DNA binding
B4072_RS20900	COG0360	Binds together with S18 to 16S ribosomal RNA
B4072_RS20905	COG0012	GTP binding
B4072_RS20910	COG0243	molybdopterin cofactor binding
B4072_RS20915	COG4481	Protein conserved in bacteria
B4072_RS20920	COG3949	Membrane
B4072_RS20930	COG1475	DNA binding
B4072_RS20935	COG1192	Involved in chromosome partitioning
B4072_RS20945	COG1475	DNA binding
B4072_RS20950	COG0357	Ribosomal RNA small subunit methyltransferase G
B4072_RS20955	COG0445	tRNA wobble uridine modification
B4072_RS20960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B4072_RS20965	COG1847	R3H domain protein
B4072_RS20970	COG0706	membrane insertase activity
B4072_RS20975	COG0594	ribonuclease P activity
B4072_RS20985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4072_RS20990	COG0592	DNA-directed DNA polymerase activity
B4072_RS20995	COG2501	S4 domain
B4072_RS21000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4072_RS21010	COG0187	DNA topoisomerase II activity
B4072_RS21015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4072_RS21140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B4072_RS21145	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4072_RS21150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4072_RS21155	COG0297	glycogen (starch) synthase activity
B4072_RS21160	COG0058	SHG alpha-glucan phosphorylase activity
B4072_RS21165	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B4072_RS21170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4072_RS21175	COG0438	transferase activity, transferring glycosyl groups
B4072_RS21180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4072_RS21190	COG0438	transferase activity, transferring glycosyl groups
B4072_RS21195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4072_RS21200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4072_RS21205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4072_RS21210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4072_RS21215	COG1169	isochorismate synthase
B4072_RS21220	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B4072_RS21225	COG0596	Alpha beta hydrolase
B4072_RS21230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B4072_RS21235	COG0318	PFAM AMP-dependent synthetase and ligase
B4072_RS21240	COG4948	Mandelate Racemase Muconate Lactonizing
B4072_RS21245	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4072_RS21250	COG1121	(ABC) transporter
B4072_RS21260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4072_RS21270	COG1294	oxidase, subunit
B4072_RS21275	COG1271	oxidase subunit
B4072_RS21280	COG0254	rRNA binding
B4072_RS21285	COG0288	reversible hydration of carbon dioxide
B4072_RS21290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B4072_RS21295	COG1854	S-ribosylhomocysteine lyase activity
B4072_RS21310	COG0783	Belongs to the Dps family
B4072_RS21315	COG4824	toxin secretion phage lysis holin
B4072_RS21320	COG0494	nUDIX hydrolase
B4072_RS21325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4072_RS21330	COG1116	anion transmembrane transporter activity
B4072_RS21335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4072_RS21340	COG1506	peptidase
B4072_RS21350	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B4072_RS21355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4072_RS21360	COG0367	asparagine synthase
B4072_RS21365	COG1113	amino acid transport
B4072_RS21370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B4072_RS21375	COG2267	carboxylic ester hydrolase activity
B4072_RS21385	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4072_RS21390	COG1242	4 iron, 4 sulfur cluster binding
B4072_RS21405	COG1725	Transcriptional regulator
B4072_RS21410	COG1131	(ABC) transporter
B4072_RS21425	COG1136	(ABC) transporter
B4072_RS21430	COG0577	efflux transmembrane transporter activity
B4072_RS21435	COG0745	RESPONSE REGULATOR receiver
B4072_RS21440	COG2205	protein histidine kinase activity
B4072_RS21445	COG1136	(ABC) transporter
B4072_RS21450	COG0577	efflux transmembrane transporter activity
B4072_RS21455	COG3328	transposase activity
B4072_RS21555	COG2801	Transposase and inactivated derivatives
B4072_RS21570	COG0457	Tetratricopeptide repeat
B4072_RS21600	COG2197	response regulator