locus-tag	class	description
K6K00_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K6K00_RS00010	COG0592	DNA-directed DNA polymerase activity
K6K00_RS00015	COG2501	S4 domain
K6K00_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K6K00_RS00030	COG0187	DNA topoisomerase II activity
K6K00_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6K00_RS00070	COG0516	GMP reductase activity
K6K00_RS00070	COG0517	IMP dehydrogenase activity
K6K00_RS00075	COG1686	Belongs to the peptidase S11 family
K6K00_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K6K00_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K6K00_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K6K00_RS00100	COG1428	Deoxynucleoside kinase
K6K00_RS00105	COG1428	Deoxynucleoside kinase
K6K00_RS00110	COG1388	LysM domain
K6K00_RS00110	COG3858	chitin binding
K6K00_RS00115	COG1335	isochorismatase
K6K00_RS00120	COG0590	tRNA wobble adenosine to inosine editing
K6K00_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6K00_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K6K00_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K6K00_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
K6K00_RS00190	COG3853	Toxic anion resistance protein (TelA)
K6K00_RS00195	COG1982	Orn Lys Arg decarboxylase major
K6K00_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6K00_RS00205	COG3870	Protein conserved in bacteria
K6K00_RS00210	COG1728	Protein conserved in bacteria
K6K00_RS00215	COG0470	DNA polymerase III
K6K00_RS00220	COG1774	PSP1 C-terminal conserved region
K6K00_RS00225	COG4467	Involved in initiation control of chromosome replication
K6K00_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6K00_RS00235	COG2827	Endonuclease containing a URI domain
K6K00_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6K00_RS00245	COG2002	toxin-antitoxin pair type II binding
K6K00_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6K00_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6K00_RS00255	COG0084	hydrolase, TatD family'
K6K00_RS00260	COG3584	3D domain protein
K6K00_RS00260	COG3583	domain protein
K6K00_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K6K00_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6K00_RS00280	COG4466	Protein conserved in bacteria
K6K00_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K6K00_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6K00_RS00300	COG0251	oxidation-reduction process
K6K00_RS00305	COG2088	sporulation resulting in formation of a cellular spore
K6K00_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K6K00_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K6K00_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K6K00_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
K6K00_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6K00_RS00340	COG2002	toxin-antitoxin pair type II binding
K6K00_RS00345	COG2244	polysaccharide biosynthetic process
K6K00_RS00350	COG3956	TIGRFAM MazG family protein
K6K00_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6K00_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K6K00_RS00375	COG1098	S1 RNA binding domain
K6K00_RS00390	COG2208	phosphoserine phosphatase activity
K6K00_RS00395	COG2304	oxidoreductase activity
K6K00_RS00400	COG0515	serine threonine protein kinase
K6K00_RS00405	COG0037	tRNA processing
K6K00_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6K00_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6K00_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K6K00_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K6K00_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6K00_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6K00_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6K00_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
K6K00_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6K00_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6K00_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6K00_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6K00_RS00470	COG1396	sequence-specific DNA binding
K6K00_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6K00_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K6K00_RS00500	COG4463	regulation of RNA biosynthetic process
K6K00_RS00505	COG3880	PFAM UvrB UvrC protein
K6K00_RS00510	COG3869	Catalyzes the specific phosphorylation of arginine residues in
K6K00_RS00515	COG0542	response to heat
K6K00_RS00520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6K00_RS00525	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K6K00_RS00530	COG4956	integral membrane protein (PIN domain superfamily)
K6K00_RS00535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K6K00_RS00540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K6K00_RS00545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K6K00_RS00550	COG1045	serine acetyltransferase
K6K00_RS00555	COG0215	cysteine-tRNA ligase activity
K6K00_RS00560	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K6K00_RS00565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6K00_RS00570	COG3688	RNA-binding protein containing a PIN domain
K6K00_RS00575	COG1595	DNA-templated transcription, initiation
K6K00_RS00585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6K00_RS00590	COG0250	Participates in transcription elongation, termination and antitermination
K6K00_RS00600	COG0081	regulation of translation
K6K00_RS00605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K6K00_RS00615	COG2813	Specifically methylates the guanine in position
K6K00_RS00620	COG0085	RNA polymerase activity
K6K00_RS00625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K6K00_RS00630	COG1358	cellular component organization or biogenesis
K6K00_RS00635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K6K00_RS00640	COG0049	tRNA binding
K6K00_RS00645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K6K00_RS00650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K6K00_RS00655	COG0596	Alpha beta hydrolase
K6K00_RS00665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6K00_RS00670	COG0088	Forms part of the polypeptide exit tunnel
K6K00_RS00680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K6K00_RS00695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K6K00_RS00700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K6K00_RS00710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K6K00_RS00715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K6K00_RS00725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K6K00_RS00735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K6K00_RS00740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K6K00_RS00745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K6K00_RS00750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K6K00_RS00760	COG0200	Binds to the 23S rRNA
K6K00_RS00765	COG0201	protein transport
K6K00_RS00770	COG0563	adenylate kinase activity
K6K00_RS00775	COG0024	Methionine aminopeptidase
K6K00_RS00780	COG2163	COG2163 Ribosomal protein L14E L6E L27E
K6K00_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6K00_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K6K00_RS00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K6K00_RS00805	COG0202	RNA polymerase activity
K6K00_RS00810	COG0203	ribosomal protein L17
K6K00_RS00815	COG1122	ATPase activity
K6K00_RS00820	COG1122	ATPase activity
K6K00_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K6K00_RS00830	COG0101	tRNA pseudouridine synthase activity
K6K00_RS00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K6K00_RS00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K6K00_RS00845	COG2226	methyltransferase
K6K00_RS00855	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS00860	COG0489	protein tyrosine kinase activity
K6K00_RS00870	COG2194	sulfuric ester hydrolase activity
K6K00_RS00875	COG0726	polysaccharide deacetylase
K6K00_RS00955	COG0659	secondary active sulfate transmembrane transporter activity
K6K00_RS00960	COG0385	Bile acid
K6K00_RS00965	COG2819	hydrolase of the alpha beta superfamily
K6K00_RS00970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS00975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS00980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K00_RS00985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K00_RS00985	COG2207	Transcriptional regulator
K6K00_RS00990	COG3876	Protein conserved in bacteria
K6K00_RS00995	COG1472	Belongs to the glycosyl hydrolase 3 family
K6K00_RS01000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6K00_RS01005	COG1263	PTS System
K6K00_RS01005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS01010	COG1737	Transcriptional regulator
K6K00_RS01015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K6K00_RS01020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K00_RS01025	COG1683	Conserved Protein
K6K00_RS01055	COG1595	DNA-templated transcription, initiation
K6K00_RS01060	COG5662	AntiSigma factor
K6K00_RS01065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K6K00_RS01070	COG4856	YbbR-like protein
K6K00_RS01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6K00_RS01080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K6K00_RS01095	COG2169	Transcriptional regulator
K6K00_RS01100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6K00_RS01120	COG3002	Belongs to the UPF0753 family
K6K00_RS01125	COG0288	reversible hydration of carbon dioxide
K6K00_RS01135	COG5609	conserved protein (DUF2294)
K6K00_RS01145	COG0642	Histidine kinase
K6K00_RS01155	COG0515	serine threonine protein kinase
K6K00_RS01170	COG1113	amino acid transport
K6K00_RS01185	COG2602	Beta-lactamase
K6K00_RS01190	COG2124	cytochrome p450
K6K00_RS01200	COG0531	amino acid
K6K00_RS01205	COG0584	glycerophosphoryl diester phosphodiesterase
K6K00_RS01210	COG2271	Major facilitator Superfamily
K6K00_RS01220	COG0456	acetyltransferase
K6K00_RS01220	COG1846	Transcriptional regulator
K6K00_RS01235	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS01240	COG0697	spore germination
K6K00_RS01245	COG1917	Cupin 2, conserved barrel domain protein
K6K00_RS01245	COG2207	Transcriptional regulator
K6K00_RS01270	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K6K00_RS01275	COG3591	Belongs to the peptidase S1B family
K6K00_RS01285	COG0596	Alpha beta hydrolase
K6K00_RS01290	COG1183	phosphatidylcholine synthase activity
K6K00_RS01295	COG0586	Pfam SNARE associated Golgi protein
K6K00_RS01300	COG0688	phosphatidylethanolamine metabolic process
K6K00_RS01310	COG2312	Erythromycin esterase
K6K00_RS01315	COG2207	Transcriptional regulator
K6K00_RS01320	COG1054	Belongs to the UPF0176 family
K6K00_RS01325	COG1301	dicarboxylic acid transport
K6K00_RS01330	COG1263	PTS System
K6K00_RS01330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS01330	COG2190	(PTS) system
K6K00_RS01335	COG0363	glucosamine-6-phosphate deaminase activity
K6K00_RS01340	COG2188	Transcriptional regulator
K6K00_RS01350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6K00_RS01355	COG0833	amino acid
K6K00_RS01360	COG2040	homocysteine
K6K00_RS01370	COG2066	Belongs to the glutaminase family
K6K00_RS01375	COG4191	Histidine kinase
K6K00_RS01380	COG0784	Response regulator, receiver
K6K00_RS01385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6K00_RS01390	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS01395	COG2271	Major facilitator Superfamily
K6K00_RS01400	COG4948	Mandelate Racemase Muconate Lactonizing
K6K00_RS01405	COG2186	Transcriptional regulator
K6K00_RS01410	COG2721	sulfolactate sulfo-lyase activity
K6K00_RS01415	COG3173	Aminoglycoside phosphotransferase
K6K00_RS01425	COG0697	spore germination
K6K00_RS01430	COG0745	RESPONSE REGULATOR receiver
K6K00_RS01435	COG2205	protein histidine kinase activity
K6K00_RS01440	COG1131	(ABC) transporter
K6K00_RS01460	COG3773	Cell wall hydrolase
K6K00_RS01465	COG2304	oxidoreductase activity
K6K00_RS01475	COG3540	Alkaline phosphatase
K6K00_RS01480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6K00_RS01485	COG0805	protein transport
K6K00_RS01490	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K6K00_RS01495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6K00_RS01500	COG0477	Major facilitator Superfamily
K6K00_RS01505	COG1309	transcriptional regulator
K6K00_RS01510	COG0252	asparaginase activity
K6K00_RS01515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K6K00_RS01520	COG1714	RDD family
K6K00_RS01525	COG1405	negative regulation of cell septum assembly
K6K00_RS01525	COG3012	SEC-C Motif Domain Protein
K6K00_RS01535	COG3279	Response regulator of the LytR AlgR family
K6K00_RS01545	COG1668	transmembrane transport
K6K00_RS01550	COG0667	Aldo Keto reductase
K6K00_RS01565	COG1595	DNA-templated transcription, initiation
K6K00_RS01570	COG1595	DNA-templated transcription, initiation
K6K00_RS01575	COG1876	peptidase activity
K6K00_RS01585	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS01590	COG0366	Alpha amylase catalytic
K6K00_RS01595	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6K00_RS01600	COG1121	(ABC) transporter
K6K00_RS01605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6K00_RS01615	COG2310	stress, protein
K6K00_RS01620	COG2310	stress, protein
K6K00_RS01625	COG2310	stress, protein
K6K00_RS01630	COG0861	Integral membrane protein TerC family
K6K00_RS01640	COG3853	Toxic anion resistance protein (TelA)
K6K00_RS01645	COG0477	Major facilitator Superfamily
K6K00_RS01650	COG2814	Major facilitator Superfamily
K6K00_RS01655	COG0640	Transcriptional regulator
K6K00_RS01660	COG0517	IMP dehydrogenase activity
K6K00_RS01660	COG4175	Glycine betaine
K6K00_RS01665	COG4176	ABC-type proline glycine betaine transport system permease component
K6K00_RS01670	COG2113	Glycine betaine
K6K00_RS01675	COG1473	amidohydrolase
K6K00_RS01680	COG1288	antiporter activity
K6K00_RS01695	COG0039	L-malate dehydrogenase activity
K6K00_RS01710	COG3403	YqcI/YcgG family
K6K00_RS01725	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K6K00_RS01730	COG1660	Displays ATPase and GTPase activities
K6K00_RS01735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K6K00_RS01745	COG2226	methyltransferase
K6K00_RS01750	COG0583	DNA-binding transcription factor activity
K6K00_RS01755	COG3458	cephalosporin-C deacetylase activity
K6K00_RS01760	COG3541	Predicted nucleotidyltransferase
K6K00_RS01765	COG0506	proline dehydrogenase activity
K6K00_RS01770	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS01775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6K00_RS01780	COG2508	Transcriptional regulator
K6K00_RS01785	COG3689	TIGRFAM TIGR03943 family protein
K6K00_RS01790	COG0701	Predicted permease
K6K00_RS01795	COG2267	carboxylic ester hydrolase activity
K6K00_RS01800	COG0492	ferredoxin-NADP+ reductase activity
K6K00_RS01805	COG1587	Uroporphyrinogen-III synthase
K6K00_RS01805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6K00_RS01810	COG2146	nitrite reductase [NAD(P)H] activity
K6K00_RS01815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6K00_RS01820	COG0243	molybdopterin cofactor binding
K6K00_RS01825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6K00_RS01830	COG2223	nitrite transmembrane transporter activity
K6K00_RS01840	COG1376	ErfK ybiS ycfS ynhG family protein
K6K00_RS01855	COG0765	amino acid transport
K6K00_RS01860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K00_RS01870	COG1714	RDD family
K6K00_RS01880	COG1846	Transcriptional regulator
K6K00_RS01895	COG2723	6-phospho-beta-galactosidase activity
K6K00_RS01905	COG3209	COG3209 Rhs family protein
K6K00_RS01915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K6K00_RS01920	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K6K00_RS01925	COG1733	regulation of RNA biosynthetic process
K6K00_RS01930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS01940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS01945	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
K6K00_RS01950	COG2814	Major facilitator Superfamily
K6K00_RS01960	COG0697	spore germination
K6K00_RS01965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K00_RS01975	COG2364	Membrane
K6K00_RS01980	COG1126	abc transporter atp-binding protein
K6K00_RS01985	COG0765	amino acid transport
K6K00_RS01990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K00_RS01995	COG0583	DNA-binding transcription factor activity
K6K00_RS02000	COG0163	prenyltransferase activity
K6K00_RS02005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K6K00_RS02020	COG0596	Alpha beta hydrolase
K6K00_RS02025	COG3104	oligopeptide transport
K6K00_RS02030	COG5434	Belongs to the glycosyl hydrolase 28 family
K6K00_RS02040	COG0697	spore germination
K6K00_RS02050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K6K00_RS02055	COG1136	(ABC) transporter
K6K00_RS02060	COG0577	efflux transmembrane transporter activity
K6K00_RS02065	COG0745	RESPONSE REGULATOR receiver
K6K00_RS02070	COG5002	protein histidine kinase activity
K6K00_RS02070	COG3850	Histidine kinase
K6K00_RS02075	COG0457	Tetratricopeptide repeat
K6K00_RS02095	COG0527	aspartate kinase activity
K6K00_RS02100	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS02105	COG4605	iron ion homeostasis
K6K00_RS02110	COG4604	ABC transporter, ATP-binding protein
K6K00_RS02115	COG4607	ABC-type enterochelin transport system periplasmic component
K6K00_RS02120	COG2814	Major facilitator Superfamily
K6K00_RS02125	COG1309	transcriptional regulator
K6K00_RS02130	COG0778	Nitroreductase
K6K00_RS02135	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6K00_RS02140	COG0640	Transcriptional regulator
K6K00_RS02145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K00_RS02150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6K00_RS02155	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS02160	COG4975	Glucose uptake
K6K00_RS02165	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS02170	COG4549	nuclear export factor GLE1
K6K00_RS02175	COG1276	copper resistance
K6K00_RS02175	COG2372	response to copper ion
K6K00_RS02180	COG1349	DNA-binding transcription factor activity
K6K00_RS02190	COG2213	PTS system mannitol-specific
K6K00_RS02195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K00_RS02200	COG0246	Mannitol dehydrogenase
K6K00_RS02205	COG0473	3-isopropylmalate dehydrogenase activity
K6K00_RS02210	COG0681	Belongs to the peptidase S26 family
K6K00_RS02215	COG0412	Dienelactone hydrolase
K6K00_RS02220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6K00_RS02230	COG0561	phosphatase activity
K6K00_RS02235	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K6K00_RS02240	COG1914	H( )-stimulated, divalent metal cation uptake system
K6K00_RS02245	COG4336	lyase activity
K6K00_RS02250	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K6K00_RS02255	COG1984	allophanate hydrolase subunit 2
K6K00_RS02260	COG1414	Transcriptional regulator
K6K00_RS02265	COG2755	lipolytic protein G-D-S-L family
K6K00_RS02275	COG2329	Antibiotic biosynthesis monooxygenase
K6K00_RS02280	COG0768	penicillin binding
K6K00_RS02285	COG4989	oxidoreductase activity
K6K00_RS02290	COG3711	transcriptional antiterminator
K6K00_RS02295	COG0318	PFAM AMP-dependent synthetase and ligase
K6K00_RS02300	COG2226	methyltransferase
K6K00_RS02305	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS02310	COG1917	Cupin 2, conserved barrel domain protein
K6K00_RS02315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K00_RS02320	COG3871	stress protein (general stress protein 26)
K6K00_RS02330	COG2814	Major facilitator Superfamily
K6K00_RS02335	COG1522	sequence-specific DNA binding
K6K00_RS02340	COG0551	DNA topoisomerase type I activity
K6K00_RS02340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6K00_RS02345	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K6K00_RS02350	COG3706	GGDEF domain
K6K00_RS02355	COG5298	Protein conserved in bacteria
K6K00_RS02360	COG1215	transferase activity, transferring glycosyl groups
K6K00_RS02370	COG0531	amino acid
K6K00_RS02375	COG0494	nUDIX hydrolase
K6K00_RS02380	COG0028	Belongs to the TPP enzyme family
K6K00_RS02395	COG1914	H( )-stimulated, divalent metal cation uptake system
K6K00_RS02400	COG2261	transglycosylase associated protein
K6K00_RS02405	COG4876	unkown
K6K00_RS02410	COG2217	Heavy metal translocating P-type atpase
K6K00_RS02415	COG3729	General stress protein
K6K00_RS02420	COG0662	Cupin 2, conserved barrel domain protein
K6K00_RS02425	COG2329	Antibiotic biosynthesis monooxygenase
K6K00_RS02430	COG3546	catalase activity
K6K00_RS02435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K6K00_RS02440	COG3290	protein histidine kinase activity
K6K00_RS02445	COG4565	transcriptional regulatory protein
K6K00_RS02450	COG1301	dicarboxylic acid transport
K6K00_RS02455	COG0628	permease
K6K00_RS02460	COG1131	(ABC) transporter
K6K00_RS02465	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K6K00_RS02475	COG1960	acyl-CoA dehydrogenase activity
K6K00_RS02490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6K00_RS02495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS02500	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6K00_RS02505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6K00_RS02510	COG0513	Belongs to the DEAD box helicase family
K6K00_RS02515	COG3402	PFAM membrane-flanked domain
K6K00_RS02520	COG3428	Bacterial PH domain
K6K00_RS02525	COG0705	Rhomboid family
K6K00_RS02530	COG0736	holo-[acyl-carrier-protein] synthase activity
K6K00_RS02535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K6K00_RS02540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6K00_RS02545	COG0864	Transcriptional regulator
K6K00_RS02550	COG2337	Toxic component of a toxin-antitoxin (TA) module
K6K00_RS02555	COG1366	Belongs to the anti-sigma-factor antagonist family
K6K00_RS02560	COG1366	Belongs to the anti-sigma-factor antagonist family
K6K00_RS02565	COG2172	sigma factor antagonist activity
K6K00_RS02570	COG2208	phosphoserine phosphatase activity
K6K00_RS02575	COG1366	Belongs to the anti-sigma-factor antagonist family
K6K00_RS02580	COG2172	sigma factor antagonist activity
K6K00_RS02585	COG1191	sigma factor activity
K6K00_RS02590	COG2208	phosphoserine phosphatase activity
K6K00_RS02605	COG1673	EVE domain
K6K00_RS02610	COG1846	Transcriptional regulator
K6K00_RS02615	COG2183	response to ionizing radiation
K6K00_RS02625	COG3091	SprT-like family
K6K00_RS02665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6K00_RS02670	COG1522	sequence-specific DNA binding
K6K00_RS02675	COG1522	sequence-specific DNA binding
K6K00_RS02680	COG1335	isochorismatase
K6K00_RS02685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K6K00_RS02690	COG2814	Major facilitator Superfamily
K6K00_RS02710	COG0693	protein deglycase activity
K6K00_RS02715	COG1278	Cold shock
K6K00_RS02720	COG1329	Transcriptional regulator
K6K00_RS02730	COG1917	Cupin 2, conserved barrel domain protein
K6K00_RS02730	COG2207	Transcriptional regulator
K6K00_RS02735	COG0697	spore germination
K6K00_RS02740	COG2207	Transcriptional regulator
K6K00_RS02740	COG3708	Transcriptional regulator
K6K00_RS02745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K00_RS02750	COG0477	Major facilitator Superfamily
K6K00_RS02760	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
K6K00_RS02770	COG0697	spore germination
K6K00_RS02775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K00_RS02780	COG2030	dehydratase
K6K00_RS02785	COG3545	Serine hydrolase
K6K00_RS02790	COG1733	regulation of RNA biosynthetic process
K6K00_RS02795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6K00_RS02800	COG1733	regulation of RNA biosynthetic process
K6K00_RS02805	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6K00_RS02810	COG2814	Major facilitator Superfamily
K6K00_RS02815	COG1309	transcriptional regulator
K6K00_RS02820	COG0640	Transcriptional regulator
K6K00_RS02825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K6K00_RS02835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K00_RS02840	COG0697	spore germination
K6K00_RS02845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K00_RS02850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6K00_RS02855	COG0640	Transcriptional regulator
K6K00_RS02860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6K00_RS02875	COG4585	Histidine kinase
K6K00_RS02880	COG2197	response regulator
K6K00_RS02885	COG2409	Drug exporters of the RND superfamily
K6K00_RS02890	COG0596	Alpha beta hydrolase
K6K00_RS02895	COG1811	Na channel or pump
K6K00_RS02900	COG0789	Transcriptional regulator
K6K00_RS02900	COG4978	Transcriptional regulator
K6K00_RS02905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6K00_RS02910	COG0778	Nitroreductase
K6K00_RS02915	COG0346	lactoylglutathione lyase activity
K6K00_RS02920	COG2259	Doxx family
K6K00_RS02925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS02940	COG2323	membrane
K6K00_RS02945	COG2323	membrane
K6K00_RS02950	COG0071	Belongs to the small heat shock protein (HSP20) family
K6K00_RS02965	COG1309	transcriptional regulator
K6K00_RS02975	COG0456	acetyltransferase
K6K00_RS02980	COG0488	(ABC) transporter
K6K00_RS02985	COG1113	amino acid transport
K6K00_RS02990	COG2318	DinB family
K6K00_RS02995	COG1846	Transcriptional regulator
K6K00_RS03000	COG2409	Drug exporters of the RND superfamily
K6K00_RS03000	COG1033	growth of symbiont in host cell
K6K00_RS03005	COG0778	Nitroreductase
K6K00_RS03010	COG1846	Transcriptional regulator
K6K00_RS03015	COG2814	Major facilitator Superfamily
K6K00_RS03020	COG0730	response to heat
K6K00_RS03025	COG1802	Transcriptional regulator
K6K00_RS03030	COG1388	LysM domain
K6K00_RS03030	COG3858	chitin binding
K6K00_RS03035	COG1819	glycosyl
K6K00_RS03045	COG1785	Belongs to the alkaline phosphatase family
K6K00_RS03050	COG5646	InterPro IPR014922
K6K00_RS03060	COG0454	-acetyltransferase
K6K00_RS03065	COG1078	dGTPase activity
K6K00_RS03070	COG1388	LysM domain
K6K00_RS03075	COG2814	Major facilitator Superfamily
K6K00_RS03080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6K00_RS03095	COG2723	6-phospho-beta-galactosidase activity
K6K00_RS03100	COG2188	Transcriptional regulator
K6K00_RS03105	COG1940	carbohydrate kinase activity
K6K00_RS03110	COG1482	cell wall glycoprotein biosynthetic process
K6K00_RS03115	COG4124	Belongs to the glycosyl hydrolase 26 family
K6K00_RS03160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K6K00_RS03165	COG0802	atpase or kinase
K6K00_RS03170	COG1214	PFAM Peptidase M22, glycoprotease
K6K00_RS03175	COG0456	acetyltransferase
K6K00_RS03180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K6K00_RS03185	COG0488	(ABC) transporter
K6K00_RS03190	COG0315	cyclic pyranopterin monophosphate synthase activity
K6K00_RS03195	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K6K00_RS03200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6K00_RS03205	COG0805	protein transport
K6K00_RS03215	COG1266	CAAX protease self-immunity
K6K00_RS03225	COG0459	protein refolding
K6K00_RS03235	COG3378	Phage plasmid primase P4 family
K6K00_RS03250	COG0270	DNA (cytosine-5-)-methyltransferase activity
K6K00_RS03255	COG0270	DNA (cytosine-5-)-methyltransferase activity
K6K00_RS03275	COG1401	restriction endodeoxyribonuclease activity
K6K00_RS03295	COG0457	Tetratricopeptide repeat
K6K00_RS03300	COG1063	alcohol dehydrogenase
K6K00_RS03305	COG2211	Major facilitator Superfamily
K6K00_RS03310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K00_RS03315	COG1842	Phage shock protein A
K6K00_RS03320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6K00_RS03325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K6K00_RS03330	COG4260	virion core protein, lumpy skin disease virus
K6K00_RS03340	COG2814	Major facilitator Superfamily
K6K00_RS03345	COG1063	alcohol dehydrogenase
K6K00_RS03350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K6K00_RS03355	COG0823	Involved in the tonB-independent uptake of proteins
K6K00_RS03370	COG2267	carboxylic ester hydrolase activity
K6K00_RS03380	COG2132	Multicopper oxidase
K6K00_RS03385	COG1113	amino acid transport
K6K00_RS03395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6K00_RS03400	COG0714	Associated with various cellular activities
K6K00_RS03405	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
K6K00_RS03410	COG1305	Transglutaminase-like
K6K00_RS03415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K6K00_RS03415	COG0519	Catalyzes the synthesis of GMP from XMP
K6K00_RS03420	COG2252	PERMEase
K6K00_RS03425	COG3064	Membrane
K6K00_RS03435	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K6K00_RS03445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6K00_RS03450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6K00_RS03455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6K00_RS03460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6K00_RS03465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6K00_RS03470	COG0047	phosphoribosylformylglycinamidine synthase activity
K6K00_RS03475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6K00_RS03480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6K00_RS03485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K6K00_RS03490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6K00_RS03495	COG0138	bifunctional purine biosynthesis protein purh
K6K00_RS03500	COG0151	Belongs to the GarS family
K6K00_RS03505	COG1522	sequence-specific DNA binding
K6K00_RS03510	COG0531	amino acid
K6K00_RS03520	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K6K00_RS03525	COG1470	cell adhesion involved in biofilm formation
K6K00_RS03530	COG4496	protein, YerC YecD
K6K00_RS03535	COG0069	glutamate synthase activity
K6K00_RS03540	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
K6K00_RS03545	COG0210	DNA helicase
K6K00_RS03550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K6K00_RS03555	COG4851	CamS sex pheromone cAM373 precursor
K6K00_RS03565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6K00_RS03570	COG1285	pathogenesis
K6K00_RS03575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6K00_RS03580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K6K00_RS03585	COG0154	amidase activity
K6K00_RS03590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K6K00_RS03600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6K00_RS03605	COG1597	lipid kinase activity
K6K00_RS03610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6K00_RS03640	COG5444	nuclease activity
K6K00_RS03650	COG0457	Tetratricopeptide repeat
K6K00_RS03660	COG0217	transcriptional regulatory protein
K6K00_RS03670	COG1309	transcriptional regulator
K6K00_RS03685	COG3546	catalase activity
K6K00_RS03690	COG0454	-acetyltransferase
K6K00_RS03700	COG5578	integral membrane protein
K6K00_RS03705	COG2972	Histidine kinase
K6K00_RS03715	COG1653	transport
K6K00_RS03720	COG1175	transmembrane transport
K6K00_RS03725	COG0395	ABC-type sugar transport system, permease component
K6K00_RS03730	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6K00_RS03735	COG2207	Transcriptional regulator
K6K00_RS03740	COG2755	lipolytic protein G-D-S-L family
K6K00_RS03750	COG5578	integral membrane protein
K6K00_RS03755	COG3401	FG-GAP repeat protein
K6K00_RS03760	COG3401	FG-GAP repeat protein
K6K00_RS03765	COG2755	lipolytic protein G-D-S-L family
K6K00_RS03780	COG1653	transport
K6K00_RS03785	COG4209	transmembrane transport
K6K00_RS03790	COG0395	ABC-type sugar transport system, permease component
K6K00_RS03795	COG1486	melibiose metabolic process
K6K00_RS03800	COG2323	membrane
K6K00_RS03805	COG2329	Antibiotic biosynthesis monooxygenase
K6K00_RS03810	COG0346	lactoylglutathione lyase activity
K6K00_RS03825	COG5583	Uncharacterized small protein (DUF2292)
K6K00_RS03830	COG0670	Belongs to the BI1 family
K6K00_RS03845	COG3328	transposase activity
K6K00_RS03855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6K00_RS03855	COG2124	cytochrome p450
K6K00_RS03860	COG1368	sulfuric ester hydrolase activity
K6K00_RS03865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K6K00_RS03870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6K00_RS03875	COG1442	glycosyl transferase family 8
K6K00_RS03880	COG1216	Glycosyl transferase, family 2
K6K00_RS03885	COG1442	glycosyl transferase family 8
K6K00_RS03890	COG2223	nitrite transmembrane transporter activity
K6K00_RS03895	COG1011	Hydrolase
K6K00_RS03900	COG0531	amino acid
K6K00_RS03905	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS03910	COG0840	transmembrane signaling receptor activity
K6K00_RS03915	COG0488	(ABC) transporter
K6K00_RS03925	COG0789	Transcriptional regulator
K6K00_RS03930	COG2814	Major facilitator Superfamily
K6K00_RS03940	COG0488	(ABC) transporter
K6K00_RS03945	COG0513	Belongs to the DEAD box helicase family
K6K00_RS03950	COG0456	acetyltransferase
K6K00_RS03955	COG2130	NADP-dependent
K6K00_RS03960	COG2211	Major facilitator Superfamily
K6K00_RS03965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K6K00_RS03970	COG1120	ATPase activity
K6K00_RS03975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS03980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS03985	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6K00_RS04000	COG3866	Pectate lyase
K6K00_RS04005	COG0471	metal ion transport
K6K00_RS04010	COG3290	protein histidine kinase activity
K6K00_RS04015	COG4565	transcriptional regulatory protein
K6K00_RS04020	COG3181	Tripartite tricarboxylate transporter family receptor
K6K00_RS04025	COG2851	Citrate transporter
K6K00_RS04030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K00_RS04035	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K6K00_RS04040	COG1254	Belongs to the acylphosphatase family
K6K00_RS04045	COG2258	MOSC domain
K6K00_RS04065	COG0024	Methionine aminopeptidase
K6K00_RS04070	COG1263	PTS System
K6K00_RS04070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS04075	COG1368	sulfuric ester hydrolase activity
K6K00_RS04090	COG1115	amino acid carrier protein
K6K00_RS04095	COG0531	amino acid
K6K00_RS04110	COG0697	spore germination
K6K00_RS04115	COG1263	PTS System
K6K00_RS04115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS04120	COG0366	Alpha amylase catalytic
K6K00_RS04125	COG2188	Transcriptional regulator
K6K00_RS04130	COG0778	Nitroreductase
K6K00_RS04135	COG0737	Belongs to the 5'-nucleotidase family
K6K00_RS04140	COG0693	protein deglycase activity
K6K00_RS04145	COG2814	Major facilitator Superfamily
K6K00_RS04150	COG4840	Belongs to the UPF0435 family
K6K00_RS04155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6K00_RS04160	COG4980	gas vesicle protein
K6K00_RS04165	COG1295	ribonuclease BN
K6K00_RS04170	COG0477	Major facilitator Superfamily
K6K00_RS04175	COG0387	Pfam Sodium calcium exchanger
K6K00_RS04185	COG0668	transmembrane transport
K6K00_RS04190	COG0535	radical SAM domain protein
K6K00_RS04200	COG0726	polysaccharide deacetylase
K6K00_RS04205	COG2084	Dehydrogenase
K6K00_RS04210	COG0598	Magnesium transport protein CorA
K6K00_RS04215	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K6K00_RS04220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K6K00_RS04230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6K00_RS04235	COG4637	Psort location Cytoplasmic, score
K6K00_RS04245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6K00_RS04250	COG0022	dehydrogenase e1 component
K6K00_RS04255	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6K00_RS04260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6K00_RS04265	COG3284	Transcriptional regulator
K6K00_RS04275	COG1742	UPF0060 membrane protein
K6K00_RS04300	COG4842	Belongs to the WXG100 family
K6K00_RS04305	COG1486	melibiose metabolic process
K6K00_RS04310	COG1737	Transcriptional regulator
K6K00_RS04315	COG1263	PTS System
K6K00_RS04315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS04320	COG1132	(ABC) transporter
K6K00_RS04325	COG1132	(ABC) transporter
K6K00_RS04330	COG2259	Doxx family
K6K00_RS04335	COG2514	catechol 2,3-dioxygenase activity
K6K00_RS04340	COG1917	Cupin 2, conserved barrel domain protein
K6K00_RS04340	COG4977	sequence-specific DNA binding
K6K00_RS04345	COG2814	Major facilitator Superfamily
K6K00_RS04350	COG1082	Xylose isomerase domain protein TIM barrel
K6K00_RS04355	COG0673	inositol 2-dehydrogenase activity
K6K00_RS04360	COG4585	Histidine kinase
K6K00_RS04365	COG2197	response regulator
K6K00_RS04370	COG1131	(ABC) transporter
K6K00_RS04375	COG0842	Transport permease protein
K6K00_RS04375	COG1511	domain protein
K6K00_RS04380	COG0842	Transport permease protein
K6K00_RS04385	COG1695	Transcriptional regulator
K6K00_RS04390	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K6K00_RS04395	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
K6K00_RS04400	COG1309	transcriptional regulator
K6K00_RS04405	COG2814	Major facilitator Superfamily
K6K00_RS04410	COG2318	DinB family
K6K00_RS04415	COG2814	Major facilitator Superfamily
K6K00_RS04420	COG1846	Transcriptional regulator
K6K00_RS04425	COG0392	lysyltransferase activity
K6K00_RS04425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K6K00_RS04430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K00_RS04435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS04440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS04445	COG0384	phenazine biosynthesis protein PhzF
K6K00_RS04450	COG0778	Nitroreductase
K6K00_RS04465	COG1090	epimerase
K6K00_RS04470	COG2137	regulation of response to DNA damage stimulus
K6K00_RS04480	COG2814	Major facilitator Superfamily
K6K00_RS04495	COG3103	Sh3 type 3 domain protein
K6K00_RS04500	COG5658	integral membrane protein
K6K00_RS04505	COG0596	Alpha beta hydrolase
K6K00_RS04510	COG0463	Glycosyl transferase, family 2
K6K00_RS04515	COG4485	Bacterial membrane protein, YfhO
K6K00_RS04520	COG1988	membrane-bound metal-dependent
K6K00_RS04525	COG1194	a g-specific adenine glycosylase
K6K00_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS04550	COG3557	Belongs to the UPF0374 family
K6K00_RS04555	COG1132	(ABC) transporter
K6K00_RS04560	COG4129	membrane
K6K00_RS04565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K6K00_RS04570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6K00_RS04575	COG0735	belongs to the Fur family
K6K00_RS04685	COG4326	sporulation control protein
K6K00_RS04695	COG5577	PFAM Coat F domain
K6K00_RS04700	COG3340	Belongs to the peptidase S51 family
K6K00_RS04705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K6K00_RS04710	COG0277	FAD linked oxidase domain protein
K6K00_RS04720	COG0753	catalase activity
K6K00_RS04725	COG1116	anion transmembrane transporter activity
K6K00_RS04730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6K00_RS04735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6K00_RS04740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6K00_RS04750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K6K00_RS04760	COG1476	TRANSCRIPTIONal
K6K00_RS04770	COG3382	B3 4 domain protein
K6K00_RS04775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K6K00_RS04785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6K00_RS04790	COG0789	Transcriptional regulator
K6K00_RS04795	COG1664	Polymer-forming cytoskeletal
K6K00_RS04800	COG1664	Polymer-forming cytoskeletal
K6K00_RS04805	COG2766	serine protein kinase
K6K00_RS04810	COG2718	Belongs to the UPF0229 family
K6K00_RS04815	COG1846	Transcriptional regulator
K6K00_RS04820	COG1566	PFAM secretion protein HlyD family protein
K6K00_RS04825	COG2814	Major facilitator Superfamily
K6K00_RS04830	COG0655	NAD(P)H dehydrogenase (quinone) activity
K6K00_RS04850	COG1725	Transcriptional regulator
K6K00_RS04855	COG1131	(ABC) transporter
K6K00_RS04860	COG1131	(ABC) transporter
K6K00_RS04865	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K6K00_RS04870	COG1278	Cold shock
K6K00_RS04875	COG1464	Belongs to the NlpA lipoprotein family
K6K00_RS04880	COG3706	GGDEF domain
K6K00_RS04885	COG1823	symporter activity
K6K00_RS04910	COG0737	Belongs to the 5'-nucleotidase family
K6K00_RS04910	COG1525	nuclease
K6K00_RS04910	COG4085	toxin activity
K6K00_RS04915	COG3764	Sortase (surface protein transpeptidase)
K6K00_RS04920	COG0564	pseudouridine synthase activity
K6K00_RS04930	COG0517	IMP dehydrogenase activity
K6K00_RS04935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6K00_RS04940	COG3153	acetyltransferase
K6K00_RS04940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6K00_RS04945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6K00_RS04950	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K6K00_RS04955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6K00_RS04960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6K00_RS04965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6K00_RS04970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6K00_RS04975	COG2203	Gaf domain
K6K00_RS04975	COG4585	Histidine kinase
K6K00_RS04980	COG2197	response regulator
K6K00_RS04985	COG0431	NADPH-dependent FMN reductase
K6K00_RS05000	COG1388	LysM domain
K6K00_RS05000	COG0791	NLP P60 protein
K6K00_RS05005	COG1959	2 iron, 2 sulfur cluster binding
K6K00_RS05010	COG0668	transmembrane transport
K6K00_RS05015	COG2719	SpoVR family
K6K00_RS05020	COG1785	Belongs to the alkaline phosphatase family
K6K00_RS05025	COG0791	NLP P60 protein
K6K00_RS05025	COG1388	LysM domain
K6K00_RS05030	COG0583	DNA-binding transcription factor activity
K6K00_RS05035	COG0372	Belongs to the citrate synthase family
K6K00_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS05045	COG0531	amino acid
K6K00_RS05050	COG0733	neurotransmitter:sodium symporter activity
K6K00_RS05055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K00_RS05060	COG0456	acetyltransferase
K6K00_RS05075	COG1595	DNA-templated transcription, initiation
K6K00_RS05080	COG0667	Aldo Keto reductase
K6K00_RS05085	COG0204	Acyl-transferase
K6K00_RS05090	COG1253	flavin adenine dinucleotide binding
K6K00_RS05095	COG0789	Transcriptional regulator
K6K00_RS05105	COG1253	flavin adenine dinucleotide binding
K6K00_RS05110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6K00_RS05115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6K00_RS05120	COG0584	glycerophosphoryl diester phosphodiesterase
K6K00_RS05130	COG0668	transmembrane transport
K6K00_RS05135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K6K00_RS05140	COG0726	polysaccharide deacetylase
K6K00_RS05145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6K00_RS05150	COG1757	Na H antiporter
K6K00_RS05155	COG0589	response to stress
K6K00_RS05165	COG1132	(ABC) transporter
K6K00_RS05170	COG1132	(ABC) transporter
K6K00_RS05175	COG0702	epimerase
K6K00_RS05200	COG0189	ligase activity
K6K00_RS05205	COG0189	ligase activity
K6K00_RS05210	COG4399	Belongs to the UPF0754 family
K6K00_RS05215	COG3679	Belongs to the UPF0342 family
K6K00_RS05225	COG0561	phosphatase activity
K6K00_RS05230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6K00_RS05235	COG0475	glutathione-regulated potassium exporter activity
K6K00_RS05240	COG0490	domain, Protein
K6K00_RS05250	COG1024	Enoyl-CoA hydratase
K6K00_RS05260	COG4152	abc transporter atp-binding protein
K6K00_RS05265	COG1668	transmembrane transport
K6K00_RS05270	COG0420	3'-5' exonuclease activity
K6K00_RS05275	COG4717	serine-type aminopeptidase activity
K6K00_RS05280	COG3481	metal-dependent phosphohydrolase, HD sub domain
K6K00_RS05290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6K00_RS05320	COG1846	Transcriptional regulator
K6K00_RS05325	COG4980	gas vesicle protein
K6K00_RS05340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K6K00_RS05345	COG0537	adenosine 5'-monophosphoramidase activity
K6K00_RS05350	COG1131	(ABC) transporter
K6K00_RS05355	COG4473	ABC transporter
K6K00_RS05365	COG1473	amidohydrolase
K6K00_RS05370	COG3069	C4-dicarboxylate transmembrane transporter activity
K6K00_RS05380	COG2329	Antibiotic biosynthesis monooxygenase
K6K00_RS05385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6K00_RS05390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K6K00_RS05395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6K00_RS05400	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K6K00_RS05405	COG1309	transcriptional regulator
K6K00_RS05410	COG1511	domain protein
K6K00_RS05415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6K00_RS05420	COG4377	Putative membrane peptidase family (DUF2324)
K6K00_RS05430	COG1363	Peptidase, m42
K6K00_RS05435	COG4405	Protein conserved in bacteria
K6K00_RS05440	COG1301	dicarboxylic acid transport
K6K00_RS05450	COG1234	tRNA 3'-trailer cleavage
K6K00_RS05455	COG0095	Lipoate-protein ligase
K6K00_RS05460	COG0702	epimerase
K6K00_RS05465	COG0318	PFAM AMP-dependent synthetase and ligase
K6K00_RS05475	COG0501	Belongs to the peptidase M48B family
K6K00_RS05485	COG0456	acetyltransferase
K6K00_RS05490	COG0604	alcohol dehydrogenase
K6K00_RS05495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6K00_RS05500	COG0406	alpha-ribazole phosphatase activity
K6K00_RS05505	COG0183	Belongs to the thiolase family
K6K00_RS05510	COG0318	PFAM AMP-dependent synthetase and ligase
K6K00_RS05515	COG1268	BioY protein
K6K00_RS05520	COG0840	transmembrane signaling receptor activity
K6K00_RS05530	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS05540	COG4903	ComK protein
K6K00_RS05545	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS05555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6K00_RS05570	COG0398	Pfam SNARE associated Golgi protein
K6K00_RS05575	COG0681	Belongs to the peptidase S26 family
K6K00_RS05580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K6K00_RS05585	COG1846	Transcriptional regulator
K6K00_RS05595	COG0738	Major facilitator superfamily
K6K00_RS05600	COG0673	inositol 2-dehydrogenase activity
K6K00_RS05605	COG0561	phosphatase activity
K6K00_RS05610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6K00_RS05615	COG1609	Transcriptional regulator
K6K00_RS05620	COG3180	Ammonia monooxygenase
K6K00_RS05625	COG2814	Major facilitator Superfamily
K6K00_RS05625	COG0477	Major facilitator Superfamily
K6K00_RS05630	COG4533	DNA binding
K6K00_RS05645	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K6K00_RS05650	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K6K00_RS05655	COG1074	ATP-dependent DNA helicase activity
K6K00_RS05660	COG0420	3'-5' exonuclease activity
K6K00_RS05665	COG0419	ATPase involved in DNA repair
K6K00_RS05670	COG1403	HNH endonuclease
K6K00_RS05710	COG5337	Spore coat protein CotH
K6K00_RS05715	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6K00_RS05725	COG1404	Belongs to the peptidase S8 family
K6K00_RS05735	COG0367	asparagine synthase
K6K00_RS05745	COG0534	Mate efflux family protein
K6K00_RS05750	COG1917	Cupin 2, conserved barrel domain protein
K6K00_RS05750	COG2207	Transcriptional regulator
K6K00_RS05755	COG1609	Transcriptional regulator
K6K00_RS05760	COG0673	inositol 2-dehydrogenase activity
K6K00_RS05765	COG2318	DinB family
K6K00_RS05770	COG1279	arginine transmembrane transporter activity
K6K00_RS05775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6K00_RS05780	COG1357	PFAM Pentapeptide repeats (8 copies)
K6K00_RS05785	COG2267	carboxylic ester hydrolase activity
K6K00_RS05790	COG0529	Catalyzes the synthesis of activated sulfate
K6K00_RS05795	COG2046	Belongs to the sulfate adenylyltransferase family
K6K00_RS05800	COG0175	sulfate reduction
K6K00_RS05805	COG2045	Belongs to the ComB family
K6K00_RS05810	COG1809	phosphosulfolactate synthase activity
K6K00_RS05815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6K00_RS05820	COG4948	Mandelate Racemase Muconate Lactonizing
K6K00_RS05825	COG2814	Major facilitator Superfamily
K6K00_RS05830	COG0454	-acetyltransferase
K6K00_RS05835	COG2153	protein acetylation
K6K00_RS05840	COG0646	methionine synthase
K6K00_RS05840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6K00_RS05845	COG1666	GTP binding
K6K00_RS05850	COG2996	Protein conserved in bacteria
K6K00_RS05870	COG1695	Transcriptional regulator
K6K00_RS05885	COG3227	Zinc metalloprotease (Elastase)
K6K00_RS05890	COG1307	EDD domain protein, DegV family
K6K00_RS05895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6K00_RS05915	COG0561	phosphatase activity
K6K00_RS05920	COG1073	alpha beta
K6K00_RS05925	COG2151	metal-sulfur cluster biosynthetic enzyme
K6K00_RS05935	COG0277	FAD linked oxidase domain protein
K6K00_RS05940	COG2271	Major facilitator Superfamily
K6K00_RS05945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6K00_RS05950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K6K00_RS05960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6K00_RS05965	COG0505	Belongs to the CarA family
K6K00_RS05970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6K00_RS05975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K6K00_RS05990	COG2267	carboxylic ester hydrolase activity
K6K00_RS06000	COG1744	ABC transporter substrate-binding protein PnrA-like
K6K00_RS06015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6K00_RS06020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6K00_RS06025	COG5504	Zn-dependent protease
K6K00_RS06030	COG0444	Belongs to the ABC transporter superfamily
K6K00_RS06035	COG4608	Belongs to the ABC transporter superfamily
K6K00_RS06045	COG0601	transmembrane transport
K6K00_RS06050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K00_RS06060	COG0180	Tryptophanyl-tRNA synthetase
K6K00_RS06065	COG4166	transmembrane transport
K6K00_RS06070	COG0601	transmembrane transport
K6K00_RS06075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K00_RS06080	COG0444	Belongs to the ABC transporter superfamily
K6K00_RS06085	COG4608	Belongs to the ABC transporter superfamily
K6K00_RS06090	COG2814	Major facilitator Superfamily
K6K00_RS06095	COG0456	acetyltransferase
K6K00_RS06100	COG1393	Belongs to the ArsC family
K6K00_RS06105	COG0861	Integral membrane protein TerC family
K6K00_RS06115	COG4862	establishment of competence for transformation
K6K00_RS06125	COG4469	Competence protein
K6K00_RS06130	COG1164	Oligoendopeptidase f
K6K00_RS06140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K6K00_RS06145	COG2346	COG2346, Truncated hemoglobins
K6K00_RS06150	COG0741	lytic transglycosylase activity
K6K00_RS06155	COG4116	CYTH
K6K00_RS06165	COG2357	RelA SpoT domain protein
K6K00_RS06170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6K00_RS06175	COG0564	pseudouridine synthase activity
K6K00_RS06180	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6K00_RS06185	COG0475	glutathione-regulated potassium exporter activity
K6K00_RS06185	COG0569	domain protein
K6K00_RS06190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6K00_RS06195	COG0352	thiamine-phosphate diphosphorylase activity
K6K00_RS06200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6K00_RS06205	COG2104	thiamine diphosphate biosynthetic process
K6K00_RS06210	COG2022	thiamine diphosphate biosynthetic process
K6K00_RS06215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6K00_RS06220	COG0351	phosphomethylpyrimidine kinase
K6K00_RS06225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K6K00_RS06280	COG0210	DNA helicase
K6K00_RS06290	COG2153	protein acetylation
K6K00_RS06295	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K6K00_RS06300	COG2382	esterase
K6K00_RS06305	COG0626	cystathionine gamma-synthase activity
K6K00_RS06310	COG0626	cystathionine gamma-synthase activity
K6K00_RS06315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K00_RS06320	COG5505	Protein of unknown function (DUF819)
K6K00_RS06350	COG3677	Transposase
K6K00_RS06365	COG5484	DNA packaging
K6K00_RS06370	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K6K00_RS06375	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS06385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K00_RS06385	COG3711	transcriptional antiterminator
K6K00_RS06390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6K00_RS06390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6K00_RS06390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K00_RS06395	COG1482	cell wall glycoprotein biosynthetic process
K6K00_RS06405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K00_RS06415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6K00_RS06430	COG0109	protoheme IX farnesyltransferase activity
K6K00_RS06440	COG0726	polysaccharide deacetylase
K6K00_RS06455	COG5504	Zn-dependent protease
K6K00_RS06460	COG2205	protein histidine kinase activity
K6K00_RS06470	COG3383	formate dehydrogenase (NAD+) activity
K6K00_RS06475	COG2427	Protein of unknown function (DUF1641)
K6K00_RS06485	COG1051	belongs to the nudix hydrolase family
K6K00_RS06495	COG2124	cytochrome p450
K6K00_RS06500	COG1819	glycosyl
K6K00_RS06510	COG1587	Uroporphyrinogen-III synthase
K6K00_RS06515	COG0390	transport system, permease component
K6K00_RS06520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6K00_RS06525	COG0697	spore germination
K6K00_RS06530	COG4297	protein containing double-stranded beta helix domain
K6K00_RS06540	COG1252	NADH dehydrogenase
K6K00_RS06545	COG1904	glucuronate isomerase
K6K00_RS06550	COG2211	Major facilitator Superfamily
K6K00_RS06555	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K6K00_RS06560	COG1063	alcohol dehydrogenase
K6K00_RS06565	COG1312	Catalyzes the dehydration of D-mannonate
K6K00_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS06575	COG2271	Major facilitator Superfamily
K6K00_RS06580	COG1609	Transcriptional regulator
K6K00_RS06585	COG0246	Mannitol dehydrogenase
K6K00_RS06590	COG2721	sulfolactate sulfo-lyase activity
K6K00_RS06595	COG0730	response to heat
K6K00_RS06600	COG2318	DinB family
K6K00_RS06605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6K00_RS06610	COG0457	Tetratricopeptide repeat
K6K00_RS06620	COG2350	Protein conserved in bacteria
K6K00_RS06625	COG1388	LysM domain
K6K00_RS06625	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS06625	COG5632	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS06635	COG4195	phage-related replication protein
K6K00_RS06640	COG3546	catalase activity
K6K00_RS06645	COG2856	Zn peptidase
K6K00_RS06650	COG1396	sequence-specific DNA binding
K6K00_RS06660	COG1522	sequence-specific DNA binding
K6K00_RS06665	COG1484	DNA-dependent DNA replication
K6K00_RS06685	COG1595	DNA-templated transcription, initiation
K6K00_RS06690	COG5484	DNA packaging
K6K00_RS06690	COG3728	DNA packaging
K6K00_RS06695	COG1783	phage Terminase large subunit
K6K00_RS06700	COG5518	Phage portal protein
K6K00_RS06705	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6K00_RS06710	COG4653	Phage capsid family
K6K00_RS06760	COG3953	SLT domain
K6K00_RS06760	COG5412	phage tail tape measure protein
K6K00_RS06765	COG1652	LysM domain
K6K00_RS06770	COG4193	domain, Protein
K6K00_RS06780	COG3628	GPW Gp25 family protein
K6K00_RS06785	COG3299	homolog of phage Mu protein gp47
K6K00_RS06790	COG3778	Protein conserved in bacteria
K6K00_RS06830	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS06830	COG5632	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS06850	COG0306	phosphate transporter
K6K00_RS06855	COG1392	Phosphate transport regulator
K6K00_RS06860	COG0531	amino acid
K6K00_RS06865	COG0346	lactoylglutathione lyase activity
K6K00_RS06875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6K00_RS06880	COG0463	Glycosyl transferase, family 2
K6K00_RS06890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6K00_RS06895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6K00_RS06900	COG2362	D-Aminopeptidase
K6K00_RS06905	COG0601	transmembrane transport
K6K00_RS06910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6K00_RS06915	COG0444	Belongs to the ABC transporter superfamily
K6K00_RS06920	COG4166	transmembrane transport
K6K00_RS06925	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6K00_RS06930	COG4948	Mandelate Racemase Muconate Lactonizing
K6K00_RS06935	COG0791	NLP P60 protein
K6K00_RS06940	COG4608	Belongs to the ABC transporter superfamily
K6K00_RS06945	COG2706	6-phosphogluconolactonase activity
K6K00_RS06950	COG1834	amidinotransferase
K6K00_RS06955	COG1607	acyl-coa hydrolase
K6K00_RS06960	COG1017	nitric oxide dioxygenase activity
K6K00_RS06960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K6K00_RS06970	COG2323	membrane
K6K00_RS06975	COG2318	DinB family
K6K00_RS06980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K00_RS06985	COG2076	Multidrug Resistance protein
K6K00_RS06990	COG2076	Multidrug Resistance protein
K6K00_RS06995	COG0788	formyltetrahydrofolate deformylase activity
K6K00_RS07000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6K00_RS07005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K6K00_RS07010	COG1764	response to oxidative stress
K6K00_RS07015	COG1846	Transcriptional regulator
K6K00_RS07020	COG1764	response to oxidative stress
K6K00_RS07030	COG0590	tRNA wobble adenosine to inosine editing
K6K00_RS07035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6K00_RS07040	COG1404	Belongs to the peptidase S8 family
K6K00_RS07045	COG1366	Belongs to the anti-sigma-factor antagonist family
K6K00_RS07050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K6K00_RS07055	COG1122	ATPase activity
K6K00_RS07060	COG4721	ABC-type cobalt transport system, permease component
K6K00_RS07070	COG0745	RESPONSE REGULATOR receiver
K6K00_RS07075	COG5002	protein histidine kinase activity
K6K00_RS07075	COG3850	Histidine kinase
K6K00_RS07080	COG3212	peptidase
K6K00_RS07085	COG3212	peptidase
K6K00_RS07095	COG2239	Acts as a magnesium transporter
K6K00_RS07100	COG0789	Transcriptional regulator
K6K00_RS07115	COG1846	Transcriptional regulator
K6K00_RS07120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6K00_RS07125	COG0726	polysaccharide deacetylase
K6K00_RS07130	COG1408	metallophosphoesterase
K6K00_RS07140	COG0463	Glycosyl transferase, family 2
K6K00_RS07150	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K6K00_RS07155	COG5001	Diguanylate cyclase
K6K00_RS07155	COG3300	MHYT domain
K6K00_RS07160	COG0586	Pfam SNARE associated Golgi protein
K6K00_RS07165	COG0861	Integral membrane protein TerC family
K6K00_RS07170	COG1191	sigma factor activity
K6K00_RS07190	COG0501	Belongs to the peptidase M48B family
K6K00_RS07195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6K00_RS07210	COG3594	Acyltransferase
K6K00_RS07215	COG5002	protein histidine kinase activity
K6K00_RS07220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6K00_RS07230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K6K00_RS07235	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K6K00_RS07240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6K00_RS07245	COG0436	Aminotransferase
K6K00_RS07250	COG1850	ribulose-bisphosphate carboxylase activity
K6K00_RS07255	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K6K00_RS07260	COG0235	Class ii aldolase
K6K00_RS07265	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K6K00_RS07270	COG3339	Conserved Protein
K6K00_RS07285	COG3852	Histidine kinase
K6K00_RS07290	COG1846	Transcriptional regulator
K6K00_RS07295	COG1360	Flagellar Motor Protein
K6K00_RS07300	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6K00_RS07305	COG0542	response to heat
K6K00_RS07310	COG3949	Membrane
K6K00_RS07315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K6K00_RS07320	COG0720	synthase
K6K00_RS07325	COG0602	queuosine metabolic process
K6K00_RS07330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K6K00_RS07335	COG1733	regulation of RNA biosynthetic process
K6K00_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS07345	COG1388	LysM domain
K6K00_RS07345	COG4641	Protein conserved in bacteria
K6K00_RS07350	COG1388	LysM domain
K6K00_RS07355	COG3858	chitin binding
K6K00_RS07365	COG4873	Protein conserved in bacteria
K6K00_RS07375	COG3773	Cell wall hydrolase
K6K00_RS07380	COG2244	polysaccharide biosynthetic process
K6K00_RS07385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS07390	COG2217	Heavy metal translocating P-type atpase
K6K00_RS07400	COG0006	proline dipeptidase activity
K6K00_RS07405	COG1609	Transcriptional regulator
K6K00_RS07410	COG3711	transcriptional antiterminator
K6K00_RS07415	COG1263	PTS System
K6K00_RS07415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS07415	COG2190	(PTS) system
K6K00_RS07420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K00_RS07425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K6K00_RS07435	COG1533	DNA photolyase activity
K6K00_RS07440	COG0456	acetyltransferase
K6K00_RS07445	COG0840	transmembrane signaling receptor activity
K6K00_RS07450	COG2084	Dehydrogenase
K6K00_RS07455	COG2340	Cysteine-rich secretory protein family
K6K00_RS07460	COG0768	penicillin binding
K6K00_RS07465	COG4191	Histidine kinase
K6K00_RS07470	COG0436	Aminotransferase
K6K00_RS07480	COG0784	Response regulator, receiver
K6K00_RS07480	COG0835	chemotaxis
K6K00_RS07490	COG2814	Major facilitator Superfamily
K6K00_RS07495	COG1376	ErfK ybiS ycfS ynhG family protein
K6K00_RS07500	COG1408	metallophosphoesterase
K6K00_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS07510	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS07515	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS07525	COG2200	EAL domain
K6K00_RS07530	COG4703	Protein of unknown function (DUF1797)
K6K00_RS07535	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
K6K00_RS07545	COG0517	IMP dehydrogenase activity
K6K00_RS07550	COG0583	DNA-binding transcription factor activity
K6K00_RS07555	COG0716	FMN binding
K6K00_RS07565	COG0716	FMN binding
K6K00_RS07570	COG2171	N-acyltransferase activity
K6K00_RS07575	COG1473	amidohydrolase
K6K00_RS07585	COG0668	transmembrane transport
K6K00_RS07590	COG0450	alkyl hydroperoxide reductase
K6K00_RS07595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS07610	COG0746	molybdenum cofactor guanylyltransferase activity
K6K00_RS07615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6K00_RS07620	COG0303	'Molybdopterin
K6K00_RS07625	COG1763	Mo-molybdopterin cofactor biosynthetic process
K6K00_RS07630	COG0314	molybdopterin synthase activity
K6K00_RS07635	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K6K00_RS07640	COG1132	(ABC) transporter
K6K00_RS07645	COG1132	(ABC) transporter
K6K00_RS07655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6K00_RS07660	COG1136	(ABC) transporter
K6K00_RS07665	COG0577	efflux transmembrane transporter activity
K6K00_RS07670	COG1349	DNA-binding transcription factor activity
K6K00_RS07675	COG1105	Belongs to the carbohydrate kinase PfkB family
K6K00_RS07680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6K00_RS07680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6K00_RS07680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K00_RS07685	COG0681	Belongs to the peptidase S26 family
K6K00_RS07695	COG0488	(ABC) transporter
K6K00_RS07700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6K00_RS07705	COG2309	aminopeptidase activity
K6K00_RS07715	COG1077	Cell shape determining protein MreB Mrl
K6K00_RS07720	COG2002	toxin-antitoxin pair type II binding
K6K00_RS07725	COG3852	Histidine kinase
K6K00_RS07730	COG2105	PFAM AIG2 family protein
K6K00_RS07730	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K6K00_RS07735	COG0569	domain protein
K6K00_RS07740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K6K00_RS07745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K6K00_RS07750	COG5503	Protein of unknown function (DUF1447)
K6K00_RS07755	COG0561	phosphatase activity
K6K00_RS07760	COG0242	peptide deformylase activity
K6K00_RS07770	COG0497	DNA recombination
K6K00_RS07775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6K00_RS07780	COG0022	dehydrogenase e1 component
K6K00_RS07785	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6K00_RS07790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6K00_RS07805	COG1982	Orn Lys Arg decarboxylase major
K6K00_RS07810	COG4476	Belongs to the UPF0223 family
K6K00_RS07815	COG4493	Belongs to the UPF0637 family
K6K00_RS07825	COG0483	inositol monophosphate 1-phosphatase activity
K6K00_RS07835	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K6K00_RS07855	COG1595	DNA-templated transcription, initiation
K6K00_RS07875	COG1217	gtp-binding protein TYPA
K6K00_RS07885	COG4896	Protein conserved in bacteria
K6K00_RS07895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6K00_RS07900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K6K00_RS07905	COG2066	Belongs to the glutaminase family
K6K00_RS07910	COG4838	Belongs to the UPF0358 family
K6K00_RS07915	COG0772	Belongs to the SEDS family
K6K00_RS07920	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K6K00_RS07925	COG1612	heme a metabolic process
K6K00_RS07930	COG0109	protoheme IX farnesyltransferase activity
K6K00_RS07935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6K00_RS07935	COG2010	Cytochrome c
K6K00_RS07940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6K00_RS07945	COG1845	cytochrome c oxidase, subunit III
K6K00_RS07950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K6K00_RS07955	COG3336	cytochrome c oxidase
K6K00_RS07965	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K6K00_RS07970	COG2340	Cysteine-rich secretory protein family
K6K00_RS07985	COG3679	Belongs to the UPF0342 family
K6K00_RS07990	COG4471	UPF0298 protein
K6K00_RS07995	COG0742	ribosomal rna small subunit methyltransferase
K6K00_RS08000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K6K00_RS08005	COG3314	Sporulation integral membrane protein YlbJ
K6K00_RS08010	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6K00_RS08015	COG3480	Lon protease (S16) C-terminal proteolytic domain
K6K00_RS08020	COG1323	Belongs to the UPF0348 family
K6K00_RS08030	COG1399	metal-binding, possibly nucleic acid-binding protein
K6K00_RS08045	COG0454	-acetyltransferase
K6K00_RS08050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6K00_RS08055	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
K6K00_RS08060	COG2001	Belongs to the MraZ family
K6K00_RS08065	COG0275	rRNA processing
K6K00_RS08070	COG4839	cell division protein FtsL
K6K00_RS08075	COG0768	penicillin binding
K6K00_RS08080	COG0768	penicillin binding
K6K00_RS08085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K6K00_RS08090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6K00_RS08095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6K00_RS08100	COG0772	Belongs to the SEDS family
K6K00_RS08105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6K00_RS08110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K6K00_RS08115	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6K00_RS08120	COG3879	Bacterial protein of unknown function (DUF881)
K6K00_RS08125	COG3879	Bacterial protein of unknown function (DUF881)
K6K00_RS08130	COG3856	small basic protein
K6K00_RS08135	COG0849	cell division
K6K00_RS08140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6K00_RS08145	COG1404	Belongs to the peptidase S8 family
K6K00_RS08145	COG4412	M6 family metalloprotease domain protein
K6K00_RS08155	COG1191	sigma factor activity
K6K00_RS08160	COG1191	sigma factor activity
K6K00_RS08165	COG1119	ATPase activity
K6K00_RS08170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6K00_RS08175	COG1873	PFAM PRC-barrel domain
K6K00_RS08180	COG1496	oxidoreductase activity
K6K00_RS08185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6K00_RS08190	COG1799	cell septum assembly
K6K00_RS08195	COG0762	integral membrane protein
K6K00_RS08200	COG2302	S4 RNA-binding domain
K6K00_RS08205	COG3599	regulation of cell shape
K6K00_RS08210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K6K00_RS08215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6K00_RS08220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K6K00_RS08225	COG0564	pseudouridine synthase activity
K6K00_RS08230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K6K00_RS08235	COG2233	PERMEase
K6K00_RS08240	COG0540	Belongs to the ATCase OTCase family
K6K00_RS08245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6K00_RS08250	COG0505	Belongs to the CarA family
K6K00_RS08255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K6K00_RS08260	COG0543	2 iron, 2 sulfur cluster binding
K6K00_RS08265	COG0167	dihydroorotate dehydrogenase activity
K6K00_RS08270	COG0284	orotidine-5'-phosphate decarboxylase activity
K6K00_RS08275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K6K00_RS08280	COG0175	sulfate reduction
K6K00_RS08285	COG0306	phosphate transporter
K6K00_RS08290	COG2046	Belongs to the sulfate adenylyltransferase family
K6K00_RS08295	COG0529	Catalyzes the synthesis of activated sulfate
K6K00_RS08300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6K00_RS08305	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
K6K00_RS08310	COG1648	precorrin-2 dehydrogenase activity
K6K00_RS08315	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K6K00_RS08320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6K00_RS08325	COG1561	YicC-like family, N-terminal region
K6K00_RS08335	COG0194	GDP metabolic process
K6K00_RS08340	COG1758	RNA polymerase activity
K6K00_RS08345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6K00_RS08350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6K00_RS08355	COG0242	peptide deformylase activity
K6K00_RS08360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6K00_RS08365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6K00_RS08365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6K00_RS08370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K6K00_RS08375	COG0631	protein serine/threonine phosphatase activity
K6K00_RS08380	COG0515	serine threonine protein kinase
K6K00_RS08380	COG2815	serine threonine protein kinase
K6K00_RS08385	COG1162	GTPase activity
K6K00_RS08390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6K00_RS08395	COG1564	THIamine pyrophosphokinase
K6K00_RS08405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K6K00_RS08410	COG1302	Protein conserved in bacteria
K6K00_RS08415	COG1461	Dihydroxyacetone kinase
K6K00_RS08420	COG1760	l-serine dehydratase
K6K00_RS08425	COG1760	l-serine dehydratase
K6K00_RS08430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6K00_RS08435	COG2050	protein possibly involved in aromatic compounds catabolism
K6K00_RS08435	COG1349	DNA-binding transcription factor activity
K6K00_RS08440	COG0416	fatty acid biosynthetic process
K6K00_RS08445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6K00_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS08460	COG0571	ribonuclease III activity
K6K00_RS08465	COG1196	nuclear chromosome segregation
K6K00_RS08470	COG0552	protein localization to endoplasmic reticulum
K6K00_RS08480	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K6K00_RS08485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6K00_RS08490	COG0228	four-way junction DNA binding
K6K00_RS08495	COG1837	Belongs to the UPF0109 family
K6K00_RS08505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K6K00_RS08510	COG0336	Belongs to the RNA methyltransferase TrmD family
K6K00_RS08515	COG0335	large ribosomal subunit rRNA binding
K6K00_RS08520	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6K00_RS08525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6K00_RS08535	COG2257	FlhB HrpN YscU SpaS Family
K6K00_RS08540	COG0045	succinate-CoA ligase (ADP-forming) activity
K6K00_RS08545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K6K00_RS08550	COG0758	DNA mediated transformation
K6K00_RS08555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6K00_RS08560	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K6K00_RS08565	COG4974	Belongs to the 'phage' integrase family
K6K00_RS08570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K6K00_RS08575	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K6K00_RS08580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K6K00_RS08585	COG1815	bacterial-type flagellum-dependent cell motility
K6K00_RS08590	COG1558	bacterial-type flagellum-dependent cell motility
K6K00_RS08595	COG1677	Flagellar hook-basal body complex protein FliE
K6K00_RS08600	COG1766	The M ring may be actively involved in energy transduction
K6K00_RS08605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6K00_RS08610	COG1317	bacterial-type flagellum organization
K6K00_RS08615	COG1157	protein secretion by the type III secretion system
K6K00_RS08620	COG2882	bacterial-type flagellum organization
K6K00_RS08625	COG3334	PFAM MgtE intracellular
K6K00_RS08630	COG3144	bacterial-type flagellum assembly
K6K00_RS08635	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K6K00_RS08640	COG4786	Flagellar basal body rod
K6K00_RS08645	COG1582	Flagellar protein (FlbD)
K6K00_RS08650	COG1580	Controls the rotational direction of flagella during chemotaxis
K6K00_RS08655	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6K00_RS08660	COG1776	CheC inhibitor of MCP methylation
K6K00_RS08660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6K00_RS08665	COG2201	protein-glutamate methylesterase activity
K6K00_RS08670	COG3190	flagellar
K6K00_RS08675	COG1338	Plays a role in the flagellum-specific transport system
K6K00_RS08680	COG1987	bacterial-type flagellum assembly
K6K00_RS08685	COG1684	flagellar biosynthetic protein fliR
K6K00_RS08690	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K6K00_RS08695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K6K00_RS08700	COG1419	protein localization to endoplasmic reticulum
K6K00_RS08705	COG0455	bacterial-type flagellum organization
K6K00_RS08710	COG2201	protein-glutamate methylesterase activity
K6K00_RS08715	COG0643	Histidine kinase
K6K00_RS08715	COG2198	Histidine kinase
K6K00_RS08720	COG0835	chemotaxis
K6K00_RS08725	COG1776	CheC inhibitor of MCP methylation
K6K00_RS08730	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K6K00_RS08735	COG1191	sigma factor activity
K6K00_RS08745	COG0052	Belongs to the universal ribosomal protein uS2 family
K6K00_RS08750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6K00_RS08755	COG0528	UMP kinase activity
K6K00_RS08760	COG0233	cytoplasmic translational termination
K6K00_RS08765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K6K00_RS08770	COG4589	Belongs to the CDS family
K6K00_RS08775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K6K00_RS08780	COG0750	zinc metalloprotease
K6K00_RS08785	COG0442	prolyl-tRNA aminoacylation
K6K00_RS08790	COG2176	DNA-directed DNA polymerase activity
K6K00_RS08795	COG0779	Required for maturation of 30S ribosomal subunits
K6K00_RS08800	COG0195	Participates in both transcription termination and antitermination
K6K00_RS08805	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K6K00_RS08810	COG1358	cellular component organization or biogenesis
K6K00_RS08815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K6K00_RS08820	COG1550	Protein conserved in bacteria
K6K00_RS08825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6K00_RS08830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K6K00_RS08835	COG0196	riboflavin kinase activity
K6K00_RS08840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K6K00_RS08845	COG1185	polyribonucleotide nucleotidyltransferase activity
K6K00_RS08855	COG0612	Peptidase, M16
K6K00_RS08860	COG1873	PFAM PRC-barrel domain
K6K00_RS08865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6K00_RS08870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6K00_RS08875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6K00_RS08880	COG0527	aspartate kinase activity
K6K00_RS08885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6K00_RS08890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K6K00_RS08895	COG0740	serine-type endopeptidase activity
K6K00_RS08905	COG4980	gas vesicle protein
K6K00_RS08905	COG1674	ftsk spoiiie
K6K00_RS08910	COG2188	Transcriptional regulator
K6K00_RS08915	COG2814	Major facilitator Superfamily
K6K00_RS08920	COG0612	Peptidase, M16
K6K00_RS08925	COG0612	Peptidase, M16
K6K00_RS08930	COG0300	oxidoreductase activity
K6K00_RS08945	COG1426	Protein conserved in bacteria
K6K00_RS08950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6K00_RS08955	COG1058	Belongs to the CinA family
K6K00_RS08955	COG1546	Belongs to the CinA family
K6K00_RS08960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K6K00_RS08965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6K00_RS08970	COG1418	mRNA catabolic process
K6K00_RS08975	COG1692	metallophosphoesterase
K6K00_RS08980	COG2359	stage V sporulation protein S
K6K00_RS08985	COG1063	alcohol dehydrogenase
K6K00_RS08990	COG0156	8-amino-7-oxononanoate synthase activity
K6K00_RS08995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6K00_RS09000	COG4550	Control of competence regulator ComK, YlbF/YmcA
K6K00_RS09010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K6K00_RS09015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K6K00_RS09030	COG3226	Transcriptional regulator
K6K00_RS09035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K00_RS09045	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6K00_RS09050	COG3321	synthase
K6K00_RS09055	COG2070	2-Nitropropane dioxygenase
K6K00_RS09055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6K00_RS09060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6K00_RS09065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6K00_RS09070	COG3425	synthase
K6K00_RS09075	COG1024	Enoyl-CoA hydratase
K6K00_RS09080	COG1024	Enoyl-CoA hydratase
K6K00_RS09085	COG0300	oxidoreductase activity
K6K00_RS09085	COG0318	PFAM AMP-dependent synthetase and ligase
K6K00_RS09085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS09085	COG3321	synthase
K6K00_RS09090	COG4221	oxidoreductase activity
K6K00_RS09090	COG3321	synthase
K6K00_RS09090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6K00_RS09090	COG0300	oxidoreductase activity
K6K00_RS09095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6K00_RS09095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6K00_RS09095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS09095	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS09095	COG3321	synthase
K6K00_RS09105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6K00_RS09105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6K00_RS09105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K6K00_RS09105	COG3321	synthase
K6K00_RS09110	COG2124	cytochrome p450
K6K00_RS09120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K00_RS09125	COG1404	Belongs to the peptidase S8 family
K6K00_RS09130	COG4195	phage-related replication protein
K6K00_RS09135	COG1764	response to oxidative stress
K6K00_RS09140	COG2076	Multidrug Resistance protein
K6K00_RS09145	COG2076	Multidrug Resistance protein
K6K00_RS09160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K6K00_RS09165	COG1923	regulation of RNA biosynthetic process
K6K00_RS09180	COG1780	Probably involved in ribonucleotide reductase function
K6K00_RS09185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6K00_RS09190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6K00_RS09195	COG4112	unkown
K6K00_RS09200	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS09205	COG0464	growth
K6K00_RS09210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6K00_RS09215	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K6K00_RS09220	COG0789	Transcriptional regulator
K6K00_RS09225	COG0174	glutamine synthetase
K6K00_RS09245	COG4282	regulation of fungal-type cell wall biogenesis
K6K00_RS09255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K00_RS09285	COG0135	phosphoribosylanthranilate isomerase activity
K6K00_RS09290	COG2211	Major facilitator Superfamily
K6K00_RS09295	COG3507	Belongs to the glycosyl hydrolase 43 family
K6K00_RS09300	COG1940	carbohydrate kinase activity
K6K00_RS09305	COG2115	Belongs to the xylose isomerase family
K6K00_RS09310	COG1070	Carbohydrate kinase
K6K00_RS09320	COG1525	nuclease
K6K00_RS09325	COG2814	Major facilitator Superfamily
K6K00_RS09330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6K00_RS09340	COG0756	dUTP diphosphatase activity
K6K00_RS09355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6K00_RS09380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K6K00_RS09395	COG3832	glyoxalase III activity
K6K00_RS09405	COG0697	spore germination
K6K00_RS09410	COG0531	amino acid
K6K00_RS09440	COG4195	phage-related replication protein
K6K00_RS09450	COG0346	lactoylglutathione lyase activity
K6K00_RS09455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6K00_RS09460	COG1388	LysM domain
K6K00_RS09465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6K00_RS09470	COG4224	UPF0291 protein
K6K00_RS09475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K6K00_RS09485	COG3763	UPF0154 protein
K6K00_RS09495	COG0785	Cytochrome C biogenesis protein
K6K00_RS09500	COG2201	protein-glutamate methylesterase activity
K6K00_RS09505	COG4846	Membrane protein involved in cytochrome C biogenesis
K6K00_RS09515	COG0071	Belongs to the small heat shock protein (HSP20) family
K6K00_RS09530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K6K00_RS09535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS09555	COG0824	Thioesterase
K6K00_RS09565	COG4841	protein insertion into membrane
K6K00_RS09570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K6K00_RS09575	COG1832	CoA-binding protein
K6K00_RS09580	COG0187	DNA topoisomerase II activity
K6K00_RS09585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6K00_RS09595	COG1115	amino acid carrier protein
K6K00_RS09600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K6K00_RS09610	COG5520	Belongs to the glycosyl hydrolase 30 family
K6K00_RS09615	COG3507	Belongs to the glycosyl hydrolase 43 family
K6K00_RS09620	COG2246	polysaccharide biosynthetic process
K6K00_RS09625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K6K00_RS09630	COG0586	Pfam SNARE associated Golgi protein
K6K00_RS09635	COG2404	hydrolase activity, acting on ester bonds
K6K00_RS09640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6K00_RS09645	COG1024	Enoyl-CoA hydratase
K6K00_RS09650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6K00_RS09655	COG0511	ligase activity, forming carbon-carbon bonds
K6K00_RS09660	COG0439	Biotin carboxylase
K6K00_RS09665	COG0318	PFAM AMP-dependent synthetase and ligase
K6K00_RS09670	COG1960	acyl-CoA dehydrogenase activity
K6K00_RS09685	COG1649	PFAM Uncharacterised BCR, COG1649
K6K00_RS09695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS09695	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K6K00_RS09700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS09705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS09710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS09715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS09720	COG2027	D-alanyl-D-alanine carboxypeptidase
K6K00_RS09725	COG2017	converts alpha-aldose to the beta-anomer
K6K00_RS09730	COG0534	Mate efflux family protein
K6K00_RS09745	COG0582	viral genome integration into host DNA
K6K00_RS09750	COG0166	Belongs to the GPI family
K6K00_RS09755	COG0405	Gamma-glutamyltransferase
K6K00_RS09760	COG0583	DNA-binding transcription factor activity
K6K00_RS09765	COG0604	alcohol dehydrogenase
K6K00_RS09770	COG0493	'glutamate synthase
K6K00_RS09775	COG0067	glutamate synthase
K6K00_RS09775	COG0069	glutamate synthase activity
K6K00_RS09775	COG0070	glutamate synthase
K6K00_RS09780	COG0583	DNA-binding transcription factor activity
K6K00_RS09785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6K00_RS09790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6K00_RS09800	COG0300	oxidoreductase activity
K6K00_RS09805	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
K6K00_RS09815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K00_RS09820	COG2814	Major facilitator Superfamily
K6K00_RS09825	COG1070	Carbohydrate kinase
K6K00_RS09830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6K00_RS09835	COG0243	molybdopterin cofactor binding
K6K00_RS09865	COG0840	transmembrane signaling receptor activity
K6K00_RS09865	COG5278	phosphoserine phosphatase activity
K6K00_RS09870	COG2368	4-hydroxyphenylacetate
K6K00_RS09875	COG4305	rare lipoprotein A
K6K00_RS09880	COG3619	membrane
K6K00_RS09885	COG3866	Pectate lyase
K6K00_RS09890	COG2135	peptidase activity
K6K00_RS09900	COG2140	Oxalate decarboxylase
K6K00_RS09915	COG0456	acetyltransferase
K6K00_RS09935	COG2720	vancomycin resistance protein
K6K00_RS09945	COG3655	Transcriptional regulator
K6K00_RS09950	COG3739	integral membrane protein
K6K00_RS09955	COG0583	DNA-binding transcription factor activity
K6K00_RS09960	COG0697	spore germination
K6K00_RS09970	COG0693	protein deglycase activity
K6K00_RS09975	COG2367	Beta-lactamase
K6K00_RS09990	COG0574	Belongs to the PEP-utilizing enzyme family
K6K00_RS09990	COG3848	Pyruvate phosphate dikinase
K6K00_RS09995	COG0726	polysaccharide deacetylase
K6K00_RS10000	COG2314	TM2 domain
K6K00_RS10005	COG1396	sequence-specific DNA binding
K6K00_RS10025	COG2135	peptidase activity
K6K00_RS10065	COG0457	Tetratricopeptide repeat
K6K00_RS10090	COG5290	Psort location Cytoplasmic, score
K6K00_RS10115	COG5444	nuclease activity
K6K00_RS10120	COG4282	regulation of fungal-type cell wall biogenesis
K6K00_RS10125	COG1231	oxidoreductase activity
K6K00_RS10130	COG5434	Belongs to the glycosyl hydrolase 28 family
K6K00_RS10135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6K00_RS10140	COG2207	Transcriptional regulator
K6K00_RS10140	COG0662	Cupin 2, conserved barrel domain protein
K6K00_RS10145	COG0456	acetyltransferase
K6K00_RS10150	COG1309	transcriptional regulator
K6K00_RS10155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K00_RS10160	COG3708	Transcriptional regulator
K6K00_RS10165	COG2378	regulation of single-species biofilm formation
K6K00_RS10175	COG0640	Transcriptional regulator
K6K00_RS10180	COG0741	lytic transglycosylase activity
K6K00_RS10185	COG2322	membrane
K6K00_RS10200	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6K00_RS10205	COG3239	Fatty acid desaturase
K6K00_RS10210	COG4585	Histidine kinase
K6K00_RS10215	COG2197	response regulator
K6K00_RS10220	COG3584	3D domain protein
K6K00_RS10220	COG1388	LysM domain
K6K00_RS10225	COG0514	ATP-dependent DNA helicase (RecQ)
K6K00_RS10235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6K00_RS10240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6K00_RS10255	COG0071	Belongs to the small heat shock protein (HSP20) family
K6K00_RS10280	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS10285	COG1657	PFAM Prenyltransferase squalene oxidase
K6K00_RS10290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K6K00_RS10295	COG0733	neurotransmitter:sodium symporter activity
K6K00_RS10300	COG0385	Bile acid
K6K00_RS10305	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6K00_RS10310	COG0567	Dehydrogenase, E1 component
K6K00_RS10315	COG4548	von Willebrand factor, type A
K6K00_RS10320	COG0714	Associated with various cellular activities
K6K00_RS10325	COG2032	superoxide dismutase activity
K6K00_RS10330	COG0791	NLP P60 protein
K6K00_RS10330	COG1388	LysM domain
K6K00_RS10335	COG1819	glycosyl
K6K00_RS10340	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K6K00_RS10345	COG0534	Mate efflux family protein
K6K00_RS10350	COG1366	Belongs to the anti-sigma-factor antagonist family
K6K00_RS10355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K6K00_RS10360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K6K00_RS10370	COG2962	Rard protein
K6K00_RS10385	COG2610	gluconate transmembrane transporter activity
K6K00_RS10390	COG1942	4-Oxalocrotonate Tautomerase
K6K00_RS10395	COG1733	regulation of RNA biosynthetic process
K6K00_RS10400	COG0778	Nitroreductase
K6K00_RS10405	COG0400	carboxylic ester hydrolase activity
K6K00_RS10410	COG0346	lactoylglutathione lyase activity
K6K00_RS10420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6K00_RS10425	COG0793	Belongs to the peptidase S41A family
K6K00_RS10425	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS10430	COG2226	methyltransferase
K6K00_RS10440	COG1876	peptidase activity
K6K00_RS10445	COG0813	purine-nucleoside phosphorylase activity
K6K00_RS10460	COG0671	phosphoesterase, PA-phosphatase related
K6K00_RS10480	COG4479	Belongs to the UPF0346 family
K6K00_RS10490	COG1509	lysine 2,3-aminomutase activity
K6K00_RS10495	COG0456	acetyltransferase
K6K00_RS10500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6K00_RS10505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6K00_RS10510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6K00_RS10515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6K00_RS10530	COG0456	acetyltransferase
K6K00_RS10535	COG0463	Glycosyl transferase, family 2
K6K00_RS10550	COG4641	Protein conserved in bacteria
K6K00_RS10555	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
K6K00_RS10560	COG1086	Polysaccharide biosynthesis protein
K6K00_RS10570	COG3331	DNA recombination
K6K00_RS10625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6K00_RS10660	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K6K00_RS10665	COG0756	dUTP diphosphatase activity
K6K00_RS10670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS10700	COG1780	Probably involved in ribonucleotide reductase function
K6K00_RS10790	COG0270	DNA (cytosine-5-)-methyltransferase activity
K6K00_RS10800	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
K6K00_RS10805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K6K00_RS10830	COG3584	3D domain protein
K6K00_RS10835	COG0587	DNA-directed DNA polymerase activity
K6K00_RS10840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6K00_RS10845	COG0358	DNA primase activity
K6K00_RS10850	COG0305	Participates in initiation and elongation during chromosome replication
K6K00_RS10860	COG2887	Belongs to the helicase family. UvrD subfamily
K6K00_RS10890	COG3420	alginic acid biosynthetic process
K6K00_RS10890	COG5434	Belongs to the glycosyl hydrolase 28 family
K6K00_RS10895	COG4195	phage-related replication protein
K6K00_RS10910	COG2135	peptidase activity
K6K00_RS10915	COG1793	dna ligase
K6K00_RS10970	COG4474	Belongs to the UPF0398 family
K6K00_RS10980	COG1388	LysM domain
K6K00_RS11000	COG3645	SOS response
K6K00_RS11000	COG3646	Phage regulatory protein
K6K00_RS11055	COG3655	Transcriptional regulator
K6K00_RS11070	COG0582	viral genome integration into host DNA
K6K00_RS11150	COG3655	Transcriptional regulator
K6K00_RS11190	COG1395	domain, Protein
K6K00_RS11205	COG0776	regulation of translation
K6K00_RS11240	COG4373	Mu-like prophage FluMu protein gp28
K6K00_RS11340	COG0582	viral genome integration into host DNA
K6K00_RS11370	COG0741	lytic transglycosylase activity
K6K00_RS11370	COG1196	nuclear chromosome segregation
K6K00_RS11370	COG0739	heme binding
K6K00_RS11380	COG2433	Pfam Transposase IS66
K6K00_RS11390	COG4632	Exopolysaccharide biosynthesis protein
K6K00_RS11390	COG5434	Belongs to the glycosyl hydrolase 28 family
K6K00_RS11405	COG5632	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS11420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6K00_RS11425	COG0463	Glycosyl transferase, family 2
K6K00_RS11430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS11435	COG3271	cysteine-type peptidase activity
K6K00_RS11435	COG2274	protein secretion by the type I secretion system
K6K00_RS11450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6K00_RS11480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6K00_RS11495	COG5444	nuclease activity
K6K00_RS11500	COG4282	regulation of fungal-type cell wall biogenesis
K6K00_RS11515	COG1525	nuclease
K6K00_RS11525	COG2746	aminoglycoside 3-N-acetyltransferase activity
K6K00_RS11550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6K00_RS11560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6K00_RS11565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6K00_RS11570	COG1846	Transcriptional regulator
K6K00_RS11575	COG0534	Mate efflux family protein
K6K00_RS11585	COG4698	Protein conserved in bacteria
K6K00_RS11590	COG2755	lipolytic protein G-D-S-L family
K6K00_RS11595	COG1999	signal sequence binding
K6K00_RS11605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K6K00_RS11610	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6K00_RS11615	COG1272	protein, Hemolysin III
K6K00_RS11620	COG0204	Acyl-transferase
K6K00_RS11625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6K00_RS11630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K6K00_RS11635	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6K00_RS11645	COG2521	methyltransferase
K6K00_RS11645	COG2136	Putative SAM-dependent methyltransferase
K6K00_RS11655	COG0129	dihydroxy-acid dehydratase activity
K6K00_RS11660	COG1413	lyase activity
K6K00_RS11665	COG1418	mRNA catabolic process
K6K00_RS11670	COG0386	Belongs to the glutathione peroxidase family
K6K00_RS11675	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K6K00_RS11680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6K00_RS11690	COG1278	Cold shock
K6K00_RS11710	COG0328	RNA-DNA hybrid ribonuclease activity
K6K00_RS11715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K6K00_RS11720	COG0328	RNA-DNA hybrid ribonuclease activity
K6K00_RS11730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6K00_RS11745	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K6K00_RS11755	COG1755	Isoprenylcysteine carboxyl methyltransferase
K6K00_RS11760	COG3424	synthase
K6K00_RS11765	COG2233	PERMEase
K6K00_RS11770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6K00_RS11775	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6K00_RS11785	COG0800	Aldolase
K6K00_RS11790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K00_RS11795	COG1609	Transcriptional regulator
K6K00_RS11800	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K6K00_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS11810	COG1199	ATP-dependent helicase activity
K6K00_RS11825	COG0116	Belongs to the methyltransferase superfamily
K6K00_RS11840	COG4474	Belongs to the UPF0398 family
K6K00_RS11855	COG3359	exonuclease
K6K00_RS11860	COG1205	dead DEAH box helicase
K6K00_RS11860	COG1111	helicase
K6K00_RS11865	COG2190	(PTS) system
K6K00_RS11870	COG0071	Belongs to the small heat shock protein (HSP20) family
K6K00_RS11905	COG3331	DNA recombination
K6K00_RS11910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6K00_RS11910	COG4499	WXG100 protein secretion system (Wss), protein YukC
K6K00_RS11920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6K00_RS11925	COG3935	DnaD domain protein
K6K00_RS11930	COG0017	Asparaginyl-tRNA synthetase
K6K00_RS11935	COG0436	Aminotransferase
K6K00_RS11940	COG5353	protein conserved in bacteria
K6K00_RS11950	COG1199	ATP-dependent helicase activity
K6K00_RS11950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6K00_RS11955	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K6K00_RS11960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K6K00_RS11965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K6K00_RS11970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K6K00_RS11970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K6K00_RS11975	COG0617	tRNA 3'-terminal CCA addition
K6K00_RS11980	COG0438	transferase activity, transferring glycosyl groups
K6K00_RS11985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K6K00_RS11990	COG1803	Methylglyoxal synthase
K6K00_RS11995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K6K00_RS12000	COG1694	Mazg nucleotide pyrophosphohydrolase
K6K00_RS12005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6K00_RS12015	COG4347	Protein of unknown function (DUF1405)
K6K00_RS12020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6K00_RS12020	COG2010	Cytochrome c
K6K00_RS12025	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6K00_RS12030	COG0723	plastoquinol--plastocyanin reductase activity
K6K00_RS12040	COG5582	Belongs to the UPF0302 family
K6K00_RS12045	COG0457	Tetratricopeptide repeat
K6K00_RS12050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K6K00_RS12055	COG0287	Prephenate dehydrogenase
K6K00_RS12060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K6K00_RS12065	COG0159	tryptophan synthase activity
K6K00_RS12070	COG0133	tryptophan synthase activity
K6K00_RS12075	COG0135	phosphoribosylanthranilate isomerase activity
K6K00_RS12085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6K00_RS12090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6K00_RS12095	COG4401	Chorismate mutase type I
K6K00_RS12100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K6K00_RS12105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K6K00_RS12110	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6K00_RS12115	COG0105	UTP biosynthetic process
K6K00_RS12120	COG0142	geranyltranstransferase activity
K6K00_RS12125	COG2226	methyltransferase
K6K00_RS12130	COG0142	geranyltranstransferase activity
K6K00_RS12140	COG0302	gtp cyclohydrolase
K6K00_RS12145	COG0776	regulation of translation
K6K00_RS12150	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K6K00_RS12165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K6K00_RS12170	COG1160	GTP binding
K6K00_RS12195	COG1304	FMN binding
K6K00_RS12200	COG0539	negative regulation of cytoplasmic translation
K6K00_RS12205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K6K00_RS12215	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K6K00_RS12220	COG2959	enzyme of heme biosynthesis
K6K00_RS12225	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS12225	COG3773	Cell wall hydrolase
K6K00_RS12230	COG2339	peptidase activity
K6K00_RS12235	COG0492	ferredoxin-NADP+ reductase activity
K6K00_RS12240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6K00_RS12245	COG4862	establishment of competence for transformation
K6K00_RS12250	COG1408	metallophosphoesterase
K6K00_RS12260	COG1388	LysM domain
K6K00_RS12265	COG1266	CAAX protease self-immunity
K6K00_RS12270	COG0514	ATP-dependent DNA helicase (RecQ)
K6K00_RS12275	COG4955	Helix-turn-helix domain
K6K00_RS12280	COG1141	Ferredoxin
K6K00_RS12285	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K6K00_RS12290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6K00_RS12295	COG0710	3-dehydroquinate dehydratase activity
K6K00_RS12305	COG1595	DNA-templated transcription, initiation
K6K00_RS12310	COG5002	protein histidine kinase activity
K6K00_RS12315	COG0745	RESPONSE REGULATOR receiver
K6K00_RS12320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6K00_RS12325	COG1333	cytochrome c biogenesis protein
K6K00_RS12330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS12335	COG1187	pseudouridine synthase activity
K6K00_RS12340	COG0700	Nucleoside recognition
K6K00_RS12345	COG2715	membrane protein required for spore maturation
K6K00_RS12350	COG1686	Belongs to the peptidase S11 family
K6K00_RS12360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K6K00_RS12365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K6K00_RS12370	COG1547	Domain of unknown function (DUF309)
K6K00_RS12375	COG0456	acetyltransferase
K6K00_RS12380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K6K00_RS12385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6K00_RS12385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K6K00_RS12390	COG0307	riboflavin synthase, alpha
K6K00_RS12395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6K00_RS12395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6K00_RS12405	COG0681	Belongs to the peptidase S26 family
K6K00_RS12415	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
K6K00_RS12430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6K00_RS12435	COG4086	secreted protein
K6K00_RS12440	COG0019	diaminopimelate decarboxylase activity
K6K00_RS12445	COG0697	spore germination
K6K00_RS12460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6K00_RS12480	COG1191	sigma factor activity
K6K00_RS12485	COG2172	sigma factor antagonist activity
K6K00_RS12490	COG1366	Belongs to the anti-sigma-factor antagonist family
K6K00_RS12495	COG1686	Belongs to the peptidase S11 family
K6K00_RS12500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K6K00_RS12505	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K6K00_RS12510	COG4974	Belongs to the 'phage' integrase family
K6K00_RS12520	COG0735	belongs to the Fur family
K6K00_RS12525	COG1300	Membrane
K6K00_RS12535	COG0281	malic enzyme
K6K00_RS12540	COG1757	Na H antiporter
K6K00_RS12545	COG1027	Aspartate ammonia-lyase
K6K00_RS12550	COG0252	asparaginase activity
K6K00_RS12555	COG1396	sequence-specific DNA binding
K6K00_RS12560	COG1379	DNA repair
K6K00_RS12565	COG0494	nUDIX hydrolase
K6K00_RS12575	COG0667	Aldo Keto reductase
K6K00_RS12585	COG1073	alpha beta
K6K00_RS12595	COG4918	Iron-sulphur cluster biosynthesis
K6K00_RS12600	COG0456	acetyltransferase
K6K00_RS12600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6K00_RS12605	COG2329	Antibiotic biosynthesis monooxygenase
K6K00_RS12610	COG0456	acetyltransferase
K6K00_RS12620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6K00_RS12630	COG2211	Major facilitator Superfamily
K6K00_RS12640	COG0346	lactoylglutathione lyase activity
K6K00_RS12645	COG1072	(Pantothenic acid kinase))
K6K00_RS12650	COG3048	D-serine ammonia-lyase activity
K6K00_RS12655	COG0300	oxidoreductase activity
K6K00_RS12660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K00_RS12665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6K00_RS12670	COG4187	Peptidase family M20/M25/M40
K6K00_RS12675	COG1902	pentaerythritol trinitrate reductase activity
K6K00_RS12680	COG0596	Alpha beta hydrolase
K6K00_RS12690	COG1234	tRNA 3'-trailer cleavage
K6K00_RS12695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6K00_RS12700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6K00_RS12705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K6K00_RS12715	COG0706	membrane insertase activity
K6K00_RS12720	COG3361	conserved protein (COG2071)
K6K00_RS12725	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6K00_RS12730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6K00_RS12735	COG0346	lactoylglutathione lyase activity
K6K00_RS12745	COG1376	ErfK ybiS ycfS ynhG family protein
K6K00_RS12750	COG4129	membrane
K6K00_RS12755	COG1126	abc transporter atp-binding protein
K6K00_RS12760	COG0765	amino acid transport
K6K00_RS12765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K00_RS12775	COG1597	lipid kinase activity
K6K00_RS12780	COG2814	Major facilitator Superfamily
K6K00_RS12785	COG0789	Transcriptional regulator
K6K00_RS12785	COG4978	Transcriptional regulator
K6K00_RS12790	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6K00_RS12795	COG0022	dehydrogenase e1 component
K6K00_RS12800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6K00_RS12805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6K00_RS12810	COG3426	butyrate kinase activity
K6K00_RS12815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6K00_RS12820	COG0280	phosphate acetyltransferase
K6K00_RS12825	COG3290	protein histidine kinase activity
K6K00_RS12825	COG3829	transcription factor binding
K6K00_RS12835	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K6K00_RS12840	COG2079	MmgE PrpD family protein
K6K00_RS12845	COG0372	Belongs to the citrate synthase family
K6K00_RS12850	COG1960	acyl-CoA dehydrogenase activity
K6K00_RS12855	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6K00_RS12860	COG0183	Belongs to the thiolase family
K6K00_RS12865	COG0584	glycerophosphoryl diester phosphodiesterase
K6K00_RS12870	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS12885	COG1902	pentaerythritol trinitrate reductase activity
K6K00_RS12890	COG0745	RESPONSE REGULATOR receiver
K6K00_RS12895	COG0750	zinc metalloprotease
K6K00_RS12900	COG0497	DNA recombination
K6K00_RS12905	COG1438	arginine binding
K6K00_RS12910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K6K00_RS12915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K6K00_RS12920	COG0142	geranyltranstransferase activity
K6K00_RS12925	COG1722	exodeoxyribonuclease VII activity
K6K00_RS12930	COG1570	exodeoxyribonuclease VII activity
K6K00_RS12935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K6K00_RS12940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6K00_RS12945	COG1302	Protein conserved in bacteria
K6K00_RS12950	COG0439	Biotin carboxylase
K6K00_RS12955	COG0511	ligase activity, forming carbon-carbon bonds
K6K00_RS12995	COG3854	ATPases associated with a variety of cellular activities
K6K00_RS13005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K6K00_RS13010	COG0006	proline dipeptidase activity
K6K00_RS13015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K6K00_RS13025	COG3872	metal-dependent enzyme
K6K00_RS13035	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6K00_RS13040	COG1321	iron dependent repressor
K6K00_RS13045	COG0095	Lipoate-protein ligase
K6K00_RS13050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6K00_RS13055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6K00_RS13060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6K00_RS13065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6K00_RS13070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6K00_RS13085	COG1396	sequence-specific DNA binding
K6K00_RS13095	COG0681	Belongs to the peptidase S26 family
K6K00_RS13120	COG4940	Competence protein ComGF
K6K00_RS13130	COG4970	Tfp pilus assembly protein FimT
K6K00_RS13135	COG4537	Required for transformation and DNA binding
K6K00_RS13140	COG1459	type II secretion system
K6K00_RS13145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K6K00_RS13150	COG0598	Magnesium transport protein CorA
K6K00_RS13155	COG1253	flavin adenine dinucleotide binding
K6K00_RS13160	COG1366	Belongs to the anti-sigma-factor antagonist family
K6K00_RS13170	COG1393	Belongs to the ArsC family
K6K00_RS13180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K00_RS13190	COG0011	TIGRFAM Protein of
K6K00_RS13200	COG2866	Carboxypeptidase
K6K00_RS13205	COG1368	sulfuric ester hydrolase activity
K6K00_RS13210	COG1940	carbohydrate kinase activity
K6K00_RS13215	COG4483	Protein conserved in bacteria
K6K00_RS13220	COG0705	Rhomboid family
K6K00_RS13220	COG0457	Tetratricopeptide repeat
K6K00_RS13230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6K00_RS13240	COG0438	transferase activity, transferring glycosyl groups
K6K00_RS13255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6K00_RS13260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6K00_RS13265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K6K00_RS13270	COG0581	inorganic phosphate transmembrane transporter activity
K6K00_RS13275	COG0573	inorganic phosphate transmembrane transporter activity
K6K00_RS13280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6K00_RS13285	COG0768	penicillin binding
K6K00_RS13290	COG0477	Major facilitator Superfamily
K6K00_RS13295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K6K00_RS13300	COG2839	Protein conserved in bacteria
K6K00_RS13305	COG5521	maltodextrose utilization protein MalA
K6K00_RS13315	COG1388	LysM domain
K6K00_RS13320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K6K00_RS13325	COG4709	membrane
K6K00_RS13330	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
K6K00_RS13335	COG0735	belongs to the Fur family
K6K00_RS13340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6K00_RS13350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K6K00_RS13355	COG0513	Belongs to the DEAD box helicase family
K6K00_RS13365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K6K00_RS13370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6K00_RS13375	COG2384	SAM-dependent methyltransferase
K6K00_RS13380	COG2010	Cytochrome c
K6K00_RS13385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6K00_RS13390	COG0358	DNA primase activity
K6K00_RS13395	COG1671	Belongs to the UPF0178 family
K6K00_RS13400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K6K00_RS13405	COG0517	IMP dehydrogenase activity
K6K00_RS13410	COG0751	glycine-tRNA ligase activity
K6K00_RS13415	COG0752	glycyl-tRNA synthetase alpha subunit
K6K00_RS13420	COG1381	Involved in DNA repair and RecF pathway recombination
K6K00_RS13430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6K00_RS13435	COG0295	cytidine deaminase activity
K6K00_RS13440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6K00_RS13445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6K00_RS13450	COG1480	7TM receptor with intracellular HD hydrolase
K6K00_RS13455	COG1702	phosphate starvation-inducible protein PhoH
K6K00_RS13460	COG0561	phosphatase activity
K6K00_RS13475	COG4864	UPF0365 protein
K6K00_RS13480	COG1030	water channel activity
K6K00_RS13485	COG1610	YqeY-like protein
K6K00_RS13495	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6K00_RS13500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6K00_RS13505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6K00_RS13510	COG2264	protein methyltransferase activity
K6K00_RS13515	COG0484	heat shock protein binding
K6K00_RS13520	COG0443	Heat shock 70 kDa protein
K6K00_RS13525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K6K00_RS13530	COG1420	regulation of RNA biosynthetic process
K6K00_RS13535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6K00_RS13540	COG0481	GTPase activity
K6K00_RS13550	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS13555	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K6K00_RS13560	COG0268	Binds directly to 16S ribosomal RNA
K6K00_RS13565	COG1466	dna polymerase III delta subunit
K6K00_RS13580	COG0658	competence protein
K6K00_RS13580	COG2333	competence protein COMEC
K6K00_RS13585	COG2131	deaminase
K6K00_RS13590	COG1596	polysaccharide export
K6K00_RS13590	COG1555	photosystem II stabilization
K6K00_RS13595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6K00_RS13600	COG2226	methyltransferase
K6K00_RS13605	COG0799	negative regulation of ribosome biogenesis
K6K00_RS13610	COG1713	HD superfamily hydrolase involved in NAD metabolism
K6K00_RS13615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6K00_RS13620	COG1534	Rna-binding protein
K6K00_RS13625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K6K00_RS13630	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6K00_RS13635	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K6K00_RS13645	COG2755	lipolytic protein G-D-S-L family
K6K00_RS13650	COG5632	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS13650	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS13655	COG0398	Pfam SNARE associated Golgi protein
K6K00_RS13660	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K6K00_RS13670	COG3209	COG3209 Rhs family protein
K6K00_RS13680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6K00_RS13685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6K00_RS13690	COG0798	PFAM Bile acid sodium symporter
K6K00_RS13695	COG0346	lactoylglutathione lyase activity
K6K00_RS13700	COG0640	Transcriptional regulator
K6K00_RS13705	COG3403	YqcI/YcgG family
K6K00_RS13710	COG0457	Tetratricopeptide repeat
K6K00_RS13725	COG5444	nuclease activity
K6K00_RS13750	COG5632	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS13750	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS13755	COG4824	toxin secretion phage lysis holin
K6K00_RS13785	COG3778	Protein conserved in bacteria
K6K00_RS13790	COG3299	homolog of phage Mu protein gp47
K6K00_RS13795	COG3628	GPW Gp25 family protein
K6K00_RS13805	COG4193	domain, Protein
K6K00_RS13810	COG1652	LysM domain
K6K00_RS13815	COG3953	SLT domain
K6K00_RS13815	COG5280	Phage tail tape measure protein TP901
K6K00_RS13880	COG4653	Phage capsid family
K6K00_RS13885	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K6K00_RS13895	COG2369	cell adhesion
K6K00_RS13900	COG5518	Phage portal protein
K6K00_RS13905	COG1783	phage Terminase large subunit
K6K00_RS13910	COG5484	DNA packaging
K6K00_RS13920	COG3677	Transposase
K6K00_RS13935	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K6K00_RS13945	COG1484	DNA-dependent DNA replication
K6K00_RS13950	COG3935	DnaD domain protein
K6K00_RS13955	COG3723	Recombinational DNA repair protein, rece pathway
K6K00_RS13960	COG5377	YqaJ viral recombinase family
K6K00_RS13990	COG1476	TRANSCRIPTIONal
K6K00_RS13995	COG3620	sequence-specific DNA binding
K6K00_RS14005	COG0563	adenylate kinase activity
K6K00_RS14010	COG2856	Zn peptidase
K6K00_RS14035	COG3223	Belongs to the PsiE family
K6K00_RS14040	COG0642	Histidine kinase
K6K00_RS14040	COG5002	protein histidine kinase activity
K6K00_RS14045	COG0745	RESPONSE REGULATOR receiver
K6K00_RS14050	COG2311	Membrane
K6K00_RS14060	COG0454	-acetyltransferase
K6K00_RS14065	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6K00_RS14075	COG0730	response to heat
K6K00_RS14080	COG0425	Belongs to the sulfur carrier protein TusA family
K6K00_RS14085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6K00_RS14085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K00_RS14095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6K00_RS14095	COG0425	Belongs to the sulfur carrier protein TusA family
K6K00_RS14100	COG2210	Belongs to the sulfur carrier protein TusA family
K6K00_RS14105	COG1937	Protein conserved in bacteria
K6K00_RS14110	COG0662	Cupin 2, conserved barrel domain protein
K6K00_RS14120	COG0789	Transcriptional regulator
K6K00_RS14120	COG4978	Transcriptional regulator
K6K00_RS14125	COG2814	Major facilitator Superfamily
K6K00_RS14130	COG0456	acetyltransferase
K6K00_RS14135	COG1253	flavin adenine dinucleotide binding
K6K00_RS14145	COG0697	spore germination
K6K00_RS14150	COG0583	DNA-binding transcription factor activity
K6K00_RS14155	COG2072	flavoprotein involved in K transport
K6K00_RS14160	COG1230	cation diffusion facilitator family transporter
K6K00_RS14165	COG1942	4-Oxalocrotonate Tautomerase
K6K00_RS14170	COG0583	DNA-binding transcription factor activity
K6K00_RS14180	COG1114	Component of the transport system for branched-chain amino acids
K6K00_RS14185	COG1687	branched-chain amino acid
K6K00_RS14190	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K6K00_RS14195	COG1522	sequence-specific DNA binding
K6K00_RS14200	COG2732	(Barnase) inhibitor
K6K00_RS14205	COG2124	cytochrome p450
K6K00_RS14215	COG1335	isochorismatase
K6K00_RS14230	COG2318	DinB family
K6K00_RS14240	COG2070	2-Nitropropane dioxygenase
K6K00_RS14245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6K00_RS14265	COG3443	Belongs to the bacterial solute-binding protein 9 family
K6K00_RS14270	COG1595	DNA-templated transcription, initiation
K6K00_RS14275	COG0667	Aldo Keto reductase
K6K00_RS14280	COG2851	Citrate transporter
K6K00_RS14285	COG0583	DNA-binding transcription factor activity
K6K00_RS14290	COG2828	Protein conserved in bacteria
K6K00_RS14295	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS14300	COG5566	PFAM Mor transcription activator
K6K00_RS14305	COG0596	Alpha beta hydrolase
K6K00_RS14310	COG4991	sh3 domain protein
K6K00_RS14315	COG4991	sh3 domain protein
K6K00_RS14325	COG0346	lactoylglutathione lyase activity
K6K00_RS14335	COG5577	PFAM Coat F domain
K6K00_RS14340	COG1063	alcohol dehydrogenase
K6K00_RS14350	COG5577	PFAM Coat F domain
K6K00_RS14355	COG0789	Transcriptional regulator
K6K00_RS14365	COG1064	alcohol dehydrogenase
K6K00_RS14370	COG0693	protein deglycase activity
K6K00_RS14375	COG1621	beta-fructofuranosidase activity
K6K00_RS14380	COG3716	PTS system mannose fructose sorbose family IID component
K6K00_RS14385	COG3715	PTS system
K6K00_RS14390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS14395	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K00_RS14400	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6K00_RS14400	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K6K00_RS14410	COG1113	amino acid transport
K6K00_RS14415	COG1280	lysine exporter protein (LysE YggA)
K6K00_RS14420	COG1378	Sugar-specific transcriptional regulator TrmB
K6K00_RS14425	COG1595	DNA-templated transcription, initiation
K6K00_RS14435	COG2755	lipolytic protein G-D-S-L family
K6K00_RS14435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6K00_RS14445	COG2124	cytochrome p450
K6K00_RS14445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6K00_RS14450	COG1309	transcriptional regulator
K6K00_RS14455	COG2226	methyltransferase
K6K00_RS14470	COG2116	formate transmembrane transporter activity
K6K00_RS14475	COG5609	conserved protein (DUF2294)
K6K00_RS14480	COG3383	formate dehydrogenase (NAD+) activity
K6K00_RS14485	COG2427	Protein of unknown function (DUF1641)
K6K00_RS14495	COG0626	cystathionine gamma-synthase activity
K6K00_RS14500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6K00_RS14505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6K00_RS14510	COG2226	methyltransferase
K6K00_RS14525	COG0768	penicillin binding
K6K00_RS14530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K6K00_RS14535	COG0572	uridine kinase
K6K00_RS14540	COG0826	peptidase U32
K6K00_RS14545	COG0826	peptidase U32
K6K00_RS14550	COG4122	O-methyltransferase activity
K6K00_RS14555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6K00_RS14560	COG3906	Belongs to the UPF0473 family
K6K00_RS14565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K6K00_RS14570	COG4472	Bacterial protein of unknown function (DUF965)
K6K00_RS14575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6K00_RS14580	COG0628	permease
K6K00_RS14585	COG1126	abc transporter atp-binding protein
K6K00_RS14590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K00_RS14595	COG0765	amino acid transport
K6K00_RS14600	COG0765	amino acid transport
K6K00_RS14615	COG3881	PFAM PRC-barrel domain
K6K00_RS14620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6K00_RS14625	COG0457	Tetratricopeptide repeat
K6K00_RS14630	COG0482	sulfurtransferase activity
K6K00_RS14635	COG1104	cysteine desulfurase activity
K6K00_RS14640	COG1959	2 iron, 2 sulfur cluster binding
K6K00_RS14645	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6K00_RS14650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6K00_RS14660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K6K00_RS14665	COG0124	histidyl-tRNA synthetase
K6K00_RS14675	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS14675	COG4991	sh3 domain protein
K6K00_RS14675	COG3103	Sh3 type 3 domain protein
K6K00_RS14685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6K00_RS14690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6K00_RS14695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K6K00_RS14695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6K00_RS14700	COG5416	Lipopolysaccharide assembly protein A domain
K6K00_RS14705	COG0490	domain, Protein
K6K00_RS14710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6K00_RS14710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6K00_RS14720	COG2244	polysaccharide biosynthetic process
K6K00_RS14725	COG2323	membrane
K6K00_RS14735	COG1862	Preprotein translocase
K6K00_RS14740	COG0343	queuine tRNA-ribosyltransferase activity
K6K00_RS14745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K6K00_RS14755	COG2255	four-way junction helicase activity
K6K00_RS14760	COG0632	four-way junction helicase activity
K6K00_RS14770	COG2814	Major facilitator Superfamily
K6K00_RS14775	COG0673	inositol 2-dehydrogenase activity
K6K00_RS14780	COG2112	serine threonine protein kinase
K6K00_RS14800	COG1115	amino acid carrier protein
K6K00_RS14805	COG0217	transcriptional regulatory protein
K6K00_RS14815	COG1388	LysM domain
K6K00_RS14820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K6K00_RS14825	COG0157	Belongs to the NadC ModD family
K6K00_RS14830	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6K00_RS14835	COG1104	cysteine desulfurase activity
K6K00_RS14840	COG1827	regulation of RNA biosynthetic process
K6K00_RS14845	COG0077	Prephenate dehydratase
K6K00_RS14850	COG4492	Belongs to the UPF0735 family
K6K00_RS14855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K6K00_RS14860	COG3290	protein histidine kinase activity
K6K00_RS14870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K6K00_RS14875	COG2868	ribosomal protein
K6K00_RS14880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K6K00_RS14885	COG1994	Peptidase M50
K6K00_RS14890	COG0739	heme binding
K6K00_RS14895	COG2894	cell division
K6K00_RS14900	COG0850	regulation of cytokinetic process
K6K00_RS14905	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K6K00_RS14915	COG1077	Cell shape determining protein MreB Mrl
K6K00_RS14920	COG2003	Belongs to the UPF0758 family
K6K00_RS14925	COG0424	maF-like protein
K6K00_RS14935	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K6K00_RS14940	COG0285	dihydrofolate synthase activity
K6K00_RS14945	COG0525	valine-tRNA ligase activity
K6K00_RS14955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6K00_RS14960	COG1388	LysM domain
K6K00_RS14965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K6K00_RS14970	COG0113	porphobilinogen synthase activity
K6K00_RS14975	COG1587	Uroporphyrinogen-III synthase
K6K00_RS14980	COG0181	hydroxymethylbilane synthase activity
K6K00_RS14985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6K00_RS14990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K6K00_RS15000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K6K00_RS15005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K6K00_RS15010	COG1067	ATP-dependent peptidase activity
K6K00_RS15010	COG0470	DNA polymerase III
K6K00_RS15015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K6K00_RS15020	COG0544	peptidyl-prolyl cis-trans isomerase activity
K6K00_RS15025	COG0457	Tetratricopeptide repeat
K6K00_RS15025	COG1477	protein flavinylation
K6K00_RS15030	COG0066	3-isopropylmalate dehydratase activity
K6K00_RS15055	COG0473	3-isopropylmalate dehydrogenase activity
K6K00_RS15060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6K00_RS15065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K6K00_RS15070	COG0440	acetolactate synthase activity
K6K00_RS15075	COG0028	Belongs to the TPP enzyme family
K6K00_RS15090	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
K6K00_RS15100	COG0622	Phosphoesterase
K6K00_RS15105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K6K00_RS15110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K6K00_RS15115	COG5401	PFAM Sporulation and spore germination
K6K00_RS15120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6K00_RS15125	COG1846	Transcriptional regulator
K6K00_RS15130	COG2197	response regulator
K6K00_RS15135	COG0824	Thioesterase
K6K00_RS15140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6K00_RS15145	COG1053	succinate dehydrogenase
K6K00_RS15150	COG2009	succinate dehydrogenase
K6K00_RS15155	COG1719	4-vinyl reductase, 4VR
K6K00_RS15160	COG0527	aspartate kinase activity
K6K00_RS15165	COG0322	excinuclease ABC activity
K6K00_RS15170	COG3118	belongs to the thioredoxin family
K6K00_RS15175	COG3534	alpha-L-arabinofuranosidase
K6K00_RS15180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6K00_RS15185	COG2086	electron transfer activity
K6K00_RS15190	COG1024	Enoyl-CoA hydratase
K6K00_RS15195	COG1309	transcriptional regulator
K6K00_RS15200	COG0318	PFAM AMP-dependent synthetase and ligase
K6K00_RS15205	COG3766	membrane
K6K00_RS15210	COG1193	negative regulation of DNA recombination
K6K00_RS15215	COG1796	DNA polymerase
K6K00_RS15215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K6K00_RS15220	COG1286	toxin biosynthetic process
K6K00_RS15225	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6K00_RS15230	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K6K00_RS15235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6K00_RS15235	COG0072	phenylalanine-tRNA ligase activity
K6K00_RS15240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K6K00_RS15250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6K00_RS15260	COG3835	regulator
K6K00_RS15265	COG0277	FAD linked oxidase domain protein
K6K00_RS15270	COG0247	lactate metabolic process
K6K00_RS15275	COG0346	lactoylglutathione lyase activity
K6K00_RS15280	COG1966	Carbon starvation protein
K6K00_RS15285	COG3534	alpha-L-arabinofuranosidase
K6K00_RS15290	COG0395	ABC-type sugar transport system, permease component
K6K00_RS15295	COG1175	transmembrane transport
K6K00_RS15300	COG1653	transport
K6K00_RS15305	COG0371	Dehydrogenase
K6K00_RS15310	COG0647	UMP catabolic process
K6K00_RS15315	COG0235	Class ii aldolase
K6K00_RS15320	COG1069	ribulokinase activity
K6K00_RS15325	COG2160	L-arabinose isomerase activity
K6K00_RS15335	COG1363	Peptidase, m42
K6K00_RS15345	COG3326	Membrane
K6K00_RS15350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K6K00_RS15355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K6K00_RS15360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K6K00_RS15370	COG1346	cytolysis
K6K00_RS15375	COG1380	Effector of murein hydrolase LrgA
K6K00_RS15380	COG3279	Response regulator of the LytR AlgR family
K6K00_RS15385	COG3275	phosphorelay sensor kinase activity
K6K00_RS15390	COG1011	Hydrolase
K6K00_RS15395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6K00_RS15405	COG0398	Pfam SNARE associated Golgi protein
K6K00_RS15410	COG1484	DNA-dependent DNA replication
K6K00_RS15415	COG3611	Membrane attachment protein
K6K00_RS15420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6K00_RS15425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K6K00_RS15430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6K00_RS15435	COG1733	regulation of RNA biosynthetic process
K6K00_RS15440	COG2814	Major facilitator Superfamily
K6K00_RS15445	COG0656	L-ascorbic acid biosynthetic process
K6K00_RS15450	COG0237	dephospho-CoA kinase activity
K6K00_RS15460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K6K00_RS15465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6K00_RS15465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6K00_RS15470	COG5002	protein histidine kinase activity
K6K00_RS15475	COG0745	RESPONSE REGULATOR receiver
K6K00_RS15480	COG0039	L-malate dehydrogenase activity
K6K00_RS15485	COG0538	isocitrate dehydrogenase activity
K6K00_RS15490	COG0372	Belongs to the citrate synthase family
K6K00_RS15495	COG2707	UPF0756 membrane protein
K6K00_RS15500	COG0628	permease
K6K00_RS15505	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6K00_RS15510	COG0469	pyruvate kinase activity
K6K00_RS15515	COG0205	6-phosphofructokinase activity
K6K00_RS15520	COG0825	malonyl-CoA metabolic process
K6K00_RS15525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K6K00_RS15530	COG0281	malic enzyme
K6K00_RS15535	COG0587	DNA-directed DNA polymerase activity
K6K00_RS15555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6K00_RS15565	COG4109	DRTGG domain
K6K00_RS15570	COG0730	response to heat
K6K00_RS15575	COG1473	amidohydrolase
K6K00_RS15580	COG0196	riboflavin kinase activity
K6K00_RS15585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6K00_RS15590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K6K00_RS15595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6K00_RS15600	COG1126	abc transporter atp-binding protein
K6K00_RS15605	COG0765	amino acid transport
K6K00_RS15610	COG0765	amino acid transport
K6K00_RS15615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K00_RS15620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K00_RS15625	COG0454	-acetyltransferase
K6K00_RS15630	COG0583	DNA-binding transcription factor activity
K6K00_RS15635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K6K00_RS15640	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS15645	COG0165	Argininosuccinate lyase
K6K00_RS15650	COG0137	argininosuccinate synthase activity
K6K00_RS15655	COG0521	Mo-molybdopterin cofactor biosynthetic process
K6K00_RS15660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K6K00_RS15670	COG0827	DNA restriction-modification system
K6K00_RS15675	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6K00_RS15680	COG3874	Sporulation protein YtfJ
K6K00_RS15690	COG1714	RDD family
K6K00_RS15695	COG0616	signal peptide processing
K6K00_RS15700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K6K00_RS15705	COG1574	metal-dependent hydrolase with the TIM-barrel fold
K6K00_RS15710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6K00_RS15720	COG0301	tRNA thio-modification
K6K00_RS15725	COG1104	cysteine desulfurase activity
K6K00_RS15730	COG1114	Component of the transport system for branched-chain amino acids
K6K00_RS15735	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K6K00_RS15740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K6K00_RS15745	COG1309	transcriptional regulator
K6K00_RS15750	COG1956	GAF domain-containing protein
K6K00_RS15755	COG2199	diguanylate cyclase activity
K6K00_RS15755	COG2203	Gaf domain
K6K00_RS15760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K6K00_RS15765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6K00_RS15770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6K00_RS15775	COG0454	-acetyltransferase
K6K00_RS15780	COG0517	IMP dehydrogenase activity
K6K00_RS15785	COG0123	including yeast histone deacetylase and acetoin utilization protein
K6K00_RS15790	COG1360	Flagellar Motor Protein
K6K00_RS15795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6K00_RS15800	COG1609	Transcriptional regulator
K6K00_RS15805	COG1605	Chorismate mutase
K6K00_RS15805	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K6K00_RS15810	COG3118	belongs to the thioredoxin family
K6K00_RS15815	COG4980	gas vesicle protein
K6K00_RS15820	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
K6K00_RS15825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K6K00_RS15830	COG1674	ftsk spoiiie
K6K00_RS15835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6K00_RS15840	COG4848	Belongs to the UPF0354 family
K6K00_RS15845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS15860	COG1363	Peptidase, m42
K6K00_RS15865	COG5584	Small secreted protein
K6K00_RS15870	COG0281	malic enzyme
K6K00_RS15875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K00_RS15880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K6K00_RS15890	COG0510	thiamine kinase activity
K6K00_RS15895	COG1523	belongs to the glycosyl hydrolase 13 family
K6K00_RS15900	COG1597	lipid kinase activity
K6K00_RS15910	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K6K00_RS15915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6K00_RS15920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6K00_RS15925	COG2252	PERMEase
K6K00_RS15930	COG4473	ABC transporter
K6K00_RS15935	COG1131	(ABC) transporter
K6K00_RS15940	COG1349	DNA-binding transcription factor activity
K6K00_RS15945	COG1187	pseudouridine synthase activity
K6K00_RS15950	COG2244	polysaccharide biosynthetic process
K6K00_RS15955	COG2081	HI0933 family
K6K00_RS15960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6K00_RS15970	COG5578	integral membrane protein
K6K00_RS15975	COG0673	inositol 2-dehydrogenase activity
K6K00_RS15980	COG1653	transport
K6K00_RS15985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K6K00_RS15990	COG4209	transmembrane transport
K6K00_RS16000	COG1653	transport
K6K00_RS16005	COG0395	ABC-type sugar transport system, permease component
K6K00_RS16010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6K00_RS16015	COG2124	cytochrome p450
K6K00_RS16020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K6K00_RS16025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K6K00_RS16030	COG0156	8-amino-7-oxononanoate synthase activity
K6K00_RS16035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6K00_RS16040	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
K6K00_RS16045	COG1073	alpha beta
K6K00_RS16050	COG1609	Transcriptional regulator
K6K00_RS16055	COG1653	transport
K6K00_RS16060	COG1175	transmembrane transport
K6K00_RS16065	COG0395	ABC-type sugar transport system, permease component
K6K00_RS16070	COG1486	melibiose metabolic process
K6K00_RS16075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6K00_RS16080	COG0495	leucyl-tRNA aminoacylation
K6K00_RS16090	COG2202	Pas domain
K6K00_RS16090	COG1366	Belongs to the anti-sigma-factor antagonist family
K6K00_RS16095	COG2814	Major facilitator Superfamily
K6K00_RS16100	COG2433	Pfam Transposase IS66
K6K00_RS16105	COG0577	efflux transmembrane transporter activity
K6K00_RS16110	COG1136	(ABC) transporter
K6K00_RS16115	COG2205	protein histidine kinase activity
K6K00_RS16120	COG0745	RESPONSE REGULATOR receiver
K6K00_RS16125	COG0577	efflux transmembrane transporter activity
K6K00_RS16130	COG1136	(ABC) transporter
K6K00_RS16145	COG1131	(ABC) transporter
K6K00_RS16150	COG1725	Transcriptional regulator
K6K00_RS16165	COG1242	4 iron, 4 sulfur cluster binding
K6K00_RS16170	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K6K00_RS16180	COG2267	carboxylic ester hydrolase activity
K6K00_RS16185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6K00_RS16190	COG1113	amino acid transport
K6K00_RS16195	COG0367	asparagine synthase
K6K00_RS16200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K6K00_RS16205	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K6K00_RS16215	COG1506	peptidase
K6K00_RS16220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6K00_RS16225	COG1116	anion transmembrane transporter activity
K6K00_RS16230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6K00_RS16235	COG0494	nUDIX hydrolase
K6K00_RS16240	COG4824	toxin secretion phage lysis holin
K6K00_RS16245	COG0783	Belongs to the Dps family
K6K00_RS16260	COG1854	S-ribosylhomocysteine lyase activity
K6K00_RS16265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K6K00_RS16270	COG0288	reversible hydration of carbon dioxide
K6K00_RS16275	COG0254	rRNA binding
K6K00_RS16280	COG1271	oxidase subunit
K6K00_RS16285	COG1294	oxidase, subunit
K6K00_RS16295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6K00_RS16300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6K00_RS16300	COG1321	iron dependent repressor
K6K00_RS16305	COG1121	(ABC) transporter
K6K00_RS16310	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6K00_RS16315	COG4948	Mandelate Racemase Muconate Lactonizing
K6K00_RS16320	COG0318	PFAM AMP-dependent synthetase and ligase
K6K00_RS16325	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6K00_RS16330	COG0596	Alpha beta hydrolase
K6K00_RS16335	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K6K00_RS16340	COG1169	isochorismate synthase
K6K00_RS16345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6K00_RS16350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K6K00_RS16355	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K6K00_RS16360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6K00_RS16365	COG0438	transferase activity, transferring glycosyl groups
K6K00_RS16375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6K00_RS16380	COG0438	transferase activity, transferring glycosyl groups
K6K00_RS16385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6K00_RS16390	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K6K00_RS16395	COG0058	SHG alpha-glucan phosphorylase activity
K6K00_RS16400	COG0297	glycogen (starch) synthase activity
K6K00_RS16405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6K00_RS16410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6K00_RS16415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K6K00_RS16540	COG3859	Proton-coupled thiamine transporter YuaJ
K6K00_RS16545	COG1247	-acetyltransferase
K6K00_RS16550	COG2268	Band 7 protein
K6K00_RS16555	COG1585	Membrane protein implicated in regulation of membrane protease activity
K6K00_RS16560	COG2318	DinB family
K6K00_RS16570	COG1454	alcohol dehydrogenase
K6K00_RS16575	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS16580	COG1510	regulation of RNA biosynthetic process
K6K00_RS16590	COG0569	domain protein
K6K00_RS16595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6K00_RS16600	COG4682	membrane
K6K00_RS16605	COG1705	Flagellar rod assembly protein muramidase FlgJ
K6K00_RS16610	COG0477	Major facilitator Superfamily
K6K00_RS16615	COG5553	Cysteine dioxygenase type I
K6K00_RS16625	COG1968	undecaprenyl-diphosphatase activity
K6K00_RS16630	COG0628	permease
K6K00_RS16635	COG0673	inositol 2-dehydrogenase activity
K6K00_RS16640	COG4806	L-rhamnose isomerase
K6K00_RS16645	COG3254	rhamnose metabolic process
K6K00_RS16650	COG1070	Carbohydrate kinase
K6K00_RS16655	COG1349	DNA-binding transcription factor activity
K6K00_RS16660	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS16660	COG3347	Dehydrogenase
K6K00_RS16665	COG0840	transmembrane signaling receptor activity
K6K00_RS16670	COG0840	transmembrane signaling receptor activity
K6K00_RS16675	COG0840	transmembrane signaling receptor activity
K6K00_RS16680	COG0840	transmembrane signaling receptor activity
K6K00_RS16695	COG0432	Pfam Uncharacterised protein family UPF0047
K6K00_RS16705	COG0366	Alpha amylase catalytic
K6K00_RS16710	COG1253	flavin adenine dinucleotide binding
K6K00_RS16715	COG2738	Putative neutral zinc metallopeptidase
K6K00_RS16730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6K00_RS16745	COG0166	Belongs to the GPI family
K6K00_RS16750	COG1979	alcohol dehydrogenase
K6K00_RS16755	COG1979	alcohol dehydrogenase
K6K00_RS16760	COG2155	Conserved Protein
K6K00_RS16765	COG1098	S1 RNA binding domain
K6K00_RS16770	COG0436	Aminotransferase
K6K00_RS16775	COG1522	sequence-specific DNA binding
K6K00_RS16780	COG2267	carboxylic ester hydrolase activity
K6K00_RS16790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6K00_RS16795	COG2205	protein histidine kinase activity
K6K00_RS16805	COG5018	Exonuclease
K6K00_RS16810	COG2814	Major facilitator Superfamily
K6K00_RS16815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6K00_RS16820	COG3011	Protein conserved in bacteria
K6K00_RS16830	COG3290	protein histidine kinase activity
K6K00_RS16835	COG4565	transcriptional regulatory protein
K6K00_RS16840	COG1744	ABC transporter substrate-binding protein PnrA-like
K6K00_RS16845	COG3845	ABC transporter
K6K00_RS16850	COG4603	Belongs to the binding-protein-dependent transport system permease family
K6K00_RS16855	COG1079	Belongs to the binding-protein-dependent transport system permease family
K6K00_RS16860	COG3493	citrate carrier protein
K6K00_RS16870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6K00_RS16870	COG2111	Na H antiporter
K6K00_RS16875	COG2111	Na H antiporter
K6K00_RS16880	COG1006	Multisubunit Na H antiporter MnhC subunit
K6K00_RS16885	COG0651	ATP synthesis coupled electron transport
K6K00_RS16890	COG1863	multisubunit Na H antiporter MnhE subunit
K6K00_RS16895	COG2212	antiporter activity
K6K00_RS16900	COG1320	monovalent cation:proton antiporter activity
K6K00_RS16905	COG2050	protein possibly involved in aromatic compounds catabolism
K6K00_RS16910	COG2197	response regulator
K6K00_RS16915	COG4585	Histidine kinase
K6K00_RS16925	COG0142	geranyltranstransferase activity
K6K00_RS16945	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K6K00_RS16950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6K00_RS16955	COG1335	isochorismatase
K6K00_RS16960	COG5506	Protein of unknown function (DUF1694)
K6K00_RS16975	COG0628	permease
K6K00_RS16990	COG1418	mRNA catabolic process
K6K00_RS16995	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS17005	COG1511	domain protein
K6K00_RS17010	COG0433	COG0433 Predicted ATPase
K6K00_RS17010	COG1674	ftsk spoiiie
K6K00_RS17015	COG4499	WXG100 protein secretion system (Wss), protein YukC
K6K00_RS17020	COG5417	Belongs to the EsaB family
K6K00_RS17025	COG4842	Belongs to the WXG100 family
K6K00_RS17030	COG2508	Transcriptional regulator
K6K00_RS17030	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K6K00_RS17035	COG0686	Belongs to the AlaDH PNT family
K6K00_RS17040	COG5634	Uncharacterized conserved protein (DUF2278)
K6K00_RS17045	COG3251	PFAM MbtH domain protein
K6K00_RS17050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS17055	COG1535	isochorismatase
K6K00_RS17055	COG3433	isochorismatase activity
K6K00_RS17060	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6K00_RS17065	COG1169	isochorismate synthase
K6K00_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS17075	COG2819	hydrolase of the alpha beta superfamily
K6K00_RS17080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K6K00_RS17085	COG1268	BioY protein
K6K00_RS17090	COG2056	Na+-H+ antiporter family
K6K00_RS17095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K6K00_RS17100	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K6K00_RS17105	COG3584	3D domain protein
K6K00_RS17120	COG1252	NADH dehydrogenase
K6K00_RS17125	COG0492	ferredoxin-NADP+ reductase activity
K6K00_RS17135	COG0516	GMP reductase activity
K6K00_RS17140	COG2808	Putative FMN-binding domain
K6K00_RS17145	COG0456	acetyltransferase
K6K00_RS17150	COG0316	Belongs to the HesB IscA family
K6K00_RS17155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K6K00_RS17160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6K00_RS17165	COG4844	belongs to the
K6K00_RS17170	COG1252	NADH dehydrogenase
K6K00_RS17175	COG4837	Protein of unknown function (DUF1462)
K6K00_RS17180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K6K00_RS17185	COG1506	peptidase
K6K00_RS17185	COG4946	Tricorn protease homolog
K6K00_RS17185	COG0823	Involved in the tonB-independent uptake of proteins
K6K00_RS17190	COG0083	homoserine kinase activity
K6K00_RS17195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K6K00_RS17200	COG0460	homoserine dehydrogenase
K6K00_RS17205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6K00_RS17210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6K00_RS17215	COG0647	UMP catabolic process
K6K00_RS17220	COG2445	Protein of unknown function DUF86
K6K00_RS17225	COG4470	Protein conserved in bacteria
K6K00_RS17235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K6K00_RS17240	COG0739	heme binding
K6K00_RS17250	COG3377	Domain of unknown function (DUF1805)
K6K00_RS17255	COG0737	Belongs to the 5'-nucleotidase family
K6K00_RS17260	COG0730	response to heat
K6K00_RS17265	COG1801	Protein of unknown function DUF72
K6K00_RS17275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K6K00_RS17280	COG2508	Transcriptional regulator
K6K00_RS17285	COG2233	PERMEase
K6K00_RS17290	COG2233	PERMEase
K6K00_RS17295	COG3195	allantoin biosynthetic process
K6K00_RS17295	COG3648	Uricase
K6K00_RS17300	COG2351	hydroxyisourate hydrolase activity
K6K00_RS17310	COG2080	2 iron, 2 sulfur cluster binding
K6K00_RS17315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K6K00_RS17320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K6K00_RS17325	COG2068	MobA-Related Protein
K6K00_RS17330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K6K00_RS17335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K6K00_RS17340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6K00_RS17350	COG2356	endonuclease I
K6K00_RS17355	COG3842	ATPase activity
K6K00_RS17360	COG2188	Transcriptional regulator
K6K00_RS17365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K00_RS17370	COG0395	ABC-type sugar transport system, permease component
K6K00_RS17375	COG1175	transmembrane transport
K6K00_RS17380	COG1653	transport
K6K00_RS17385	COG2222	sugar isomerase
K6K00_RS17390	COG0322	excinuclease ABC activity
K6K00_RS17395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6K00_RS17410	COG0346	lactoylglutathione lyase activity
K6K00_RS17415	COG0640	Transcriptional regulator
K6K00_RS17420	COG0719	Fe-S assembly protein
K6K00_RS17425	COG0822	iron-sulfur transferase activity
K6K00_RS17430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6K00_RS17435	COG0719	Fe-S assembly protein
K6K00_RS17440	COG0396	ATPase activity
K6K00_RS17450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6K00_RS17455	COG1464	Belongs to the NlpA lipoprotein family
K6K00_RS17460	COG2011	ABC-type metal ion transport system permease component
K6K00_RS17465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6K00_RS17475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6K00_RS17480	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K6K00_RS17490	COG0509	glycine decarboxylation via glycine cleavage system
K6K00_RS17495	COG1393	Belongs to the ArsC family
K6K00_RS17500	COG1960	acyl-CoA dehydrogenase activity
K6K00_RS17505	COG0183	Belongs to the thiolase family
K6K00_RS17510	COG1024	Enoyl-CoA hydratase
K6K00_RS17510	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6K00_RS17520	COG0506	proline dehydrogenase activity
K6K00_RS17530	COG5577	PFAM Coat F domain
K6K00_RS17535	COG1846	Transcriptional regulator
K6K00_RS17540	COG0477	Major facilitator Superfamily
K6K00_RS17545	COG1942	4-Oxalocrotonate Tautomerase
K6K00_RS17555	COG0583	DNA-binding transcription factor activity
K6K00_RS17565	COG1120	ATPase activity
K6K00_RS17580	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS17585	COG0783	Belongs to the Dps family
K6K00_RS17590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6K00_RS17595	COG0745	RESPONSE REGULATOR receiver
K6K00_RS17600	COG2770	Histidine kinase
K6K00_RS17600	COG2205	protein histidine kinase activity
K6K00_RS17610	COG1309	transcriptional regulator
K6K00_RS17615	COG0114	fumarate hydratase activity
K6K00_RS17625	COG0697	spore germination
K6K00_RS17630	COG0814	amino acid
K6K00_RS17640	COG2197	response regulator
K6K00_RS17645	COG4585	Histidine kinase
K6K00_RS17650	COG4758	membrane
K6K00_RS17655	COG3595	metallopeptidase activity
K6K00_RS17660	COG1842	Phage shock protein A
K6K00_RS17665	COG4758	membrane
K6K00_RS17670	COG2814	Major facilitator Superfamily
K6K00_RS17675	COG2096	Adenosyltransferase
K6K00_RS17680	COG1120	ATPase activity
K6K00_RS17685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS17690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K00_RS17695	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS17700	COG3386	PFAM SMP-30 Gluconolaconase
K6K00_RS17705	COG2205	protein histidine kinase activity
K6K00_RS17710	COG0745	RESPONSE REGULATOR receiver
K6K00_RS17730	COG2140	Oxalate decarboxylase
K6K00_RS17740	COG0577	efflux transmembrane transporter activity
K6K00_RS17745	COG1136	(ABC) transporter
K6K00_RS17750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K6K00_RS17755	COG1120	ATPase activity
K6K00_RS17760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS17765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6K00_RS17770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K00_RS17775	COG0531	amino acid
K6K00_RS17785	COG1988	membrane-bound metal-dependent
K6K00_RS17790	COG1368	sulfuric ester hydrolase activity
K6K00_RS17795	COG1910	domain protein
K6K00_RS17800	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6K00_RS17805	COG4149	molybdate abc transporter
K6K00_RS17810	COG0656	L-ascorbic acid biosynthetic process
K6K00_RS17820	COG0025	NhaP-type Na H and K H
K6K00_RS17825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6K00_RS17830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K6K00_RS17835	COG3973	AAA domain
K6K00_RS17840	COG2860	membrane
K6K00_RS17845	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6K00_RS17850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6K00_RS17855	COG2217	Heavy metal translocating P-type atpase
K6K00_RS17860	COG2217	Heavy metal translocating P-type atpase
K6K00_RS17865	COG2608	mercury ion transmembrane transporter activity
K6K00_RS17870	COG1937	Protein conserved in bacteria
K6K00_RS17875	COG0673	inositol 2-dehydrogenase activity
K6K00_RS17880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K6K00_RS17885	COG1289	transmembrane transporter activity
K6K00_RS17895	COG2076	Multidrug Resistance protein
K6K00_RS17900	COG1309	transcriptional regulator
K6K00_RS17905	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS17915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K6K00_RS17920	COG0557	exoribonuclease II activity
K6K00_RS17925	COG1647	Serine aminopeptidase, S33
K6K00_RS17930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6K00_RS17935	COG0596	Alpha beta hydrolase
K6K00_RS17940	COG1476	TRANSCRIPTIONal
K6K00_RS17945	COG1396	sequence-specific DNA binding
K6K00_RS17950	COG1396	sequence-specific DNA binding
K6K00_RS17955	COG1733	regulation of RNA biosynthetic process
K6K00_RS17960	COG0840	transmembrane signaling receptor activity
K6K00_RS17965	COG1174	glycine betaine transport
K6K00_RS17970	COG1732	Glycine betaine
K6K00_RS17975	COG1174	glycine betaine transport
K6K00_RS17980	COG0517	IMP dehydrogenase activity
K6K00_RS17980	COG1125	glycine betaine transport
K6K00_RS17985	COG1510	regulation of RNA biosynthetic process
K6K00_RS18005	COG5658	integral membrane protein
K6K00_RS18010	COG0640	Transcriptional regulator
K6K00_RS18015	COG1174	glycine betaine transport
K6K00_RS18020	COG1732	Glycine betaine
K6K00_RS18025	COG1174	glycine betaine transport
K6K00_RS18030	COG0517	IMP dehydrogenase activity
K6K00_RS18030	COG1125	glycine betaine transport
K6K00_RS18035	COG1510	regulation of RNA biosynthetic process
K6K00_RS18040	COG2095	MarC family integral membrane protein
K6K00_RS18050	COG3064	Membrane
K6K00_RS18055	COG4640	response to antibiotic
K6K00_RS18060	COG0456	acetyltransferase
K6K00_RS18065	COG0148	phosphopyruvate hydratase activity
K6K00_RS18070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K6K00_RS18075	COG0149	triose-phosphate isomerase activity
K6K00_RS18080	COG0126	phosphoglycerate kinase activity
K6K00_RS18085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6K00_RS18090	COG2390	Transcriptional regulator
K6K00_RS18095	COG2814	Major facilitator Superfamily
K6K00_RS18100	COG1609	Transcriptional regulator
K6K00_RS18110	COG0583	DNA-binding transcription factor activity
K6K00_RS18135	COG1139	Iron-sulfur cluster binding protein
K6K00_RS18150	COG0456	acetyltransferase
K6K00_RS18155	COG0148	phosphopyruvate hydratase activity
K6K00_RS18175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6K00_RS18180	COG2390	Transcriptional regulator
K6K00_RS18185	COG2814	Major facilitator Superfamily
K6K00_RS18190	COG1609	Transcriptional regulator
K6K00_RS18195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6K00_RS18200	COG0583	DNA-binding transcription factor activity
K6K00_RS18205	COG0697	spore germination
K6K00_RS18210	COG1113	amino acid transport
K6K00_RS18215	COG3858	chitin binding
K6K00_RS18220	COG1556	Lactate utilization protein
K6K00_RS18225	COG1139	Iron-sulfur cluster binding protein
K6K00_RS18230	COG0247	lactate metabolic process
K6K00_RS18235	COG2197	response regulator
K6K00_RS18240	COG4585	Histidine kinase
K6K00_RS18245	COG0842	Transport permease protein
K6K00_RS18250	COG1131	(ABC) transporter
K6K00_RS18255	COG0596	Alpha beta hydrolase
K6K00_RS18260	COG2208	phosphoserine phosphatase activity
K6K00_RS18265	COG3867	Arabinogalactan endo-beta-1,4-galactanase
K6K00_RS18270	COG1874	Beta-galactosidase
K6K00_RS18275	COG3833	ABC-type maltose transport systems, permease component
K6K00_RS18280	COG1175	transmembrane transport
K6K00_RS18285	COG2182	Extracellular solute-binding protein
K6K00_RS18290	COG1609	Transcriptional regulator
K6K00_RS18295	COG2186	Transcriptional regulator
K6K00_RS18300	COG1620	l-lactate permease
K6K00_RS18305	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K6K00_RS18315	COG5039	Polysaccharide pyruvyl transferase
K6K00_RS18320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6K00_RS18325	COG0110	maltose O-acetyltransferase activity
K6K00_RS18330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6K00_RS18335	COG2244	polysaccharide biosynthetic process
K6K00_RS18340	COG1216	Glycosyl transferase, family 2
K6K00_RS18345	COG5039	Polysaccharide pyruvyl transferase
K6K00_RS18350	COG1216	Glycosyl transferase, family 2
K6K00_RS18360	COG0438	transferase activity, transferring glycosyl groups
K6K00_RS18365	COG1215	transferase activity, transferring glycosyl groups
K6K00_RS18370	COG0438	transferase activity, transferring glycosyl groups
K6K00_RS18375	COG1086	Polysaccharide biosynthesis protein
K6K00_RS18380	COG0489	protein tyrosine kinase activity
K6K00_RS18385	COG3944	biosynthesis protein
K6K00_RS18390	COG1396	sequence-specific DNA binding
K6K00_RS18395	COG2272	Belongs to the type-B carboxylesterase lipase family
K6K00_RS18405	COG3479	Phenolic acid decarboxylase
K6K00_RS18420	COG1794	racemase activity, acting on amino acids and derivatives
K6K00_RS18425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6K00_RS18430	COG1621	beta-fructofuranosidase activity
K6K00_RS18435	COG1621	beta-fructofuranosidase activity
K6K00_RS18440	COG0531	amino acid
K6K00_RS18445	COG1309	transcriptional regulator
K6K00_RS18450	COG2076	Multidrug Resistance protein
K6K00_RS18455	COG2076	Multidrug Resistance protein
K6K00_RS18465	COG0277	FAD linked oxidase domain protein
K6K00_RS18470	COG3621	Patatin-like phospholipase
K6K00_RS18480	COG0740	serine-type endopeptidase activity
K6K00_RS18485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6K00_RS18490	COG0366	Alpha amylase catalytic
K6K00_RS18495	COG1554	hydrolase, family 65, central catalytic
K6K00_RS18500	COG5521	maltodextrose utilization protein MalA
K6K00_RS18505	COG3833	ABC-type maltose transport systems, permease component
K6K00_RS18510	COG1175	transmembrane transport
K6K00_RS18515	COG2182	Extracellular solute-binding protein
K6K00_RS18525	COG1609	Transcriptional regulator
K6K00_RS18530	COG1611	Belongs to the LOG family
K6K00_RS18540	COG0659	secondary active sulfate transmembrane transporter activity
K6K00_RS18545	COG0288	reversible hydration of carbon dioxide
K6K00_RS18550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6K00_RS18555	COG0577	efflux transmembrane transporter activity
K6K00_RS18560	COG1136	(ABC) transporter
K6K00_RS18565	COG5002	protein histidine kinase activity
K6K00_RS18570	COG0745	RESPONSE REGULATOR receiver
K6K00_RS18580	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K6K00_RS18585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K00_RS18590	COG1481	regulation of sporulation
K6K00_RS18595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6K00_RS18600	COG1660	Displays ATPase and GTPase activities
K6K00_RS18605	COG1051	belongs to the nudix hydrolase family
K6K00_RS18610	COG0492	ferredoxin-NADP+ reductase activity
K6K00_RS18615	COG0791	NLP P60 protein
K6K00_RS18615	COG3883	PFAM NLP P60 protein
K6K00_RS18620	COG0457	Tetratricopeptide repeat
K6K00_RS18625	COG1132	(ABC) transporter
K6K00_RS18645	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K6K00_RS18645	COG0140	phosphoribosyl-ATP diphosphatase activity
K6K00_RS18650	COG0107	imidazoleglycerol-phosphate synthase activity
K6K00_RS18655	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K6K00_RS18660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6K00_RS18665	COG0131	Imidazoleglycerol-phosphate dehydratase
K6K00_RS18670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K6K00_RS18675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6K00_RS18680	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K6K00_RS18685	COG4990	cell redox homeostasis
K6K00_RS18690	COG5297	Belongs to the glycosyl hydrolase family 6
K6K00_RS18695	COG0110	maltose O-acetyltransferase activity
K6K00_RS18700	COG0546	phosphoglycolate phosphatase activity
K6K00_RS18705	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6K00_RS18710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K6K00_RS18715	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K6K00_RS18720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6K00_RS18725	COG0363	glucosamine-6-phosphate deaminase activity
K6K00_RS18730	COG2188	Transcriptional regulator
K6K00_RS18735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6K00_RS18740	COG1846	Transcriptional regulator
K6K00_RS18745	COG2124	cytochrome p450
K6K00_RS18755	COG1846	Transcriptional regulator
K6K00_RS18760	COG2814	Major facilitator Superfamily
K6K00_RS18765	COG1950	PFAM Membrane protein of
K6K00_RS18770	COG1983	PspC domain protein
K6K00_RS18775	COG3595	metallopeptidase activity
K6K00_RS18795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6K00_RS18800	COG0556	nucleotide-excision repair
K6K00_RS18805	COG4897	Protein conserved in bacteria
K6K00_RS18810	COG3848	Pyruvate phosphate dikinase
K6K00_RS18810	COG0574	Belongs to the PEP-utilizing enzyme family
K6K00_RS18815	COG1309	transcriptional regulator
K6K00_RS18820	COG2814	Major facilitator Superfamily
K6K00_RS18825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6K00_RS18835	COG3409	Peptidoglycan-binding domain 1 protein
K6K00_RS18835	COG0793	Belongs to the peptidase S41A family
K6K00_RS18840	COG2177	Part of the ABC transporter FtsEX involved in
K6K00_RS18845	COG2884	Cell division ATP-binding protein ftsE
K6K00_RS18850	COG2010	Cytochrome c
K6K00_RS18855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6K00_RS18865	COG0653	protein targeting
K6K00_RS18870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6K00_RS18885	COG1516	flagellar protein fliS
K6K00_RS18890	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K6K00_RS18895	COG1334	flagellar protein FlaG
K6K00_RS18900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6K00_RS18905	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K6K00_RS18910	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
K6K00_RS18920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6K00_RS18925	COG4786	Flagellar basal body rod
K6K00_RS18925	COG1256	bacterial-type flagellum assembly
K6K00_RS18930	COG3418	PFAM FlgN family protein
K6K00_RS18935	COG2747	anti-sigma28 factor FlgM
K6K00_RS18945	COG1040	competence protein
K6K00_RS18955	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K6K00_RS18960	COG1307	EDD domain protein, DegV family
K6K00_RS18965	COG2197	response regulator
K6K00_RS18970	COG4585	Histidine kinase
K6K00_RS18975	COG1739	Uncharacterized protein family UPF0029
K6K00_RS18980	COG1316	TRANSCRIPTIONal
K6K00_RS18985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6K00_RS18990	COG0438	transferase activity, transferring glycosyl groups
K6K00_RS18995	COG1215	transferase activity, transferring glycosyl groups
K6K00_RS19000	COG3206	protein involved in exopolysaccharide biosynthesis
K6K00_RS19005	COG3307	-O-antigen
K6K00_RS19010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K6K00_RS19015	COG0297	glycogen (starch) synthase activity
K6K00_RS19015	COG0438	transferase activity, transferring glycosyl groups
K6K00_RS19020	COG2244	polysaccharide biosynthetic process
K6K00_RS19030	COG2247	cell wall binding repeat
K6K00_RS19030	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6K00_RS19035	COG2247	cell wall binding repeat
K6K00_RS19035	COG2385	sporulation resulting in formation of a cellular spore
K6K00_RS19045	COG1316	TRANSCRIPTIONal
K6K00_RS19050	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6K00_RS19055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K6K00_RS19065	COG1215	transferase activity, transferring glycosyl groups
K6K00_RS19065	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K6K00_RS19070	COG0463	Glycosyl transferase, family 2
K6K00_RS19095	COG1134	teichoic acid transport
K6K00_RS19100	COG1682	transport, permease protein
K6K00_RS19105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K6K00_RS19110	COG0438	transferase activity, transferring glycosyl groups
K6K00_RS19115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K6K00_RS19120	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K6K00_RS19125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K6K00_RS19135	COG4193	domain, Protein
K6K00_RS19140	COG1482	cell wall glycoprotein biosynthetic process
K6K00_RS19145	COG0697	spore germination
K6K00_RS19150	COG0814	amino acid
K6K00_RS19160	COG2814	Major facilitator Superfamily
K6K00_RS19165	COG1316	TRANSCRIPTIONal
K6K00_RS19170	COG0561	phosphatase activity
K6K00_RS19175	COG0791	NLP P60 protein
K6K00_RS19185	COG2843	Capsule synthesis protein
K6K00_RS19195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K6K00_RS19200	COG1609	Transcriptional regulator
K6K00_RS19205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K00_RS19210	COG1869	D-ribose catabolic process
K6K00_RS19215	COG1129	ABC transporter
K6K00_RS19220	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6K00_RS19225	COG1879	ABC-type sugar transport system periplasmic component
K6K00_RS19230	COG3103	Sh3 type 3 domain protein
K6K00_RS19240	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6K00_RS19245	COG3527	Alpha-acetolactate decarboxylase
K6K00_RS19250	COG0028	Belongs to the TPP enzyme family
K6K00_RS19255	COG0583	DNA-binding transcription factor activity
K6K00_RS19260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K6K00_RS19275	COG5337	Spore coat protein CotH
K6K00_RS19285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6K00_RS19295	COG0405	Gamma-glutamyltransferase
K6K00_RS19300	COG1522	sequence-specific DNA binding
K6K00_RS19305	COG2059	Chromate
K6K00_RS19310	COG2059	Chromate
K6K00_RS19320	COG0655	NAD(P)H dehydrogenase (quinone) activity
K6K00_RS19325	COG0583	DNA-binding transcription factor activity
K6K00_RS19335	COG2849	repeat protein
K6K00_RS19340	COG5444	nuclease activity
K6K00_RS19360	COG3878	Protein conserved in bacteria
K6K00_RS19365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K6K00_RS19370	COG4464	protein tyrosine phosphatase activity
K6K00_RS19375	COG0489	protein tyrosine kinase activity
K6K00_RS19380	COG3944	biosynthesis protein
K6K00_RS19390	COG4715	Zinc finger, swim domain protein
K6K00_RS19395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6K00_RS19400	COG0561	phosphatase activity
K6K00_RS19405	COG1349	DNA-binding transcription factor activity
K6K00_RS19410	COG0629	single-stranded DNA binding
K6K00_RS19435	COG2972	Histidine kinase
K6K00_RS19435	COG0745	RESPONSE REGULATOR receiver
K6K00_RS19440	COG1970	mechanosensitive ion channel activity
K6K00_RS19445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6K00_RS19450	COG0457	Tetratricopeptide repeat
K6K00_RS19455	COG4786	Flagellar basal body rod
K6K00_RS19460	COG4786	Flagellar basal body rod
K6K00_RS19465	COG1077	Cell shape determining protein MreB Mrl
K6K00_RS19470	COG1609	Transcriptional regulator
K6K00_RS19480	COG1846	Transcriptional regulator
K6K00_RS19485	COG2814	Major facilitator Superfamily
K6K00_RS19490	COG3420	alginic acid biosynthetic process
K6K00_RS19495	COG1953	Uracil, thiamine, allantoin
K6K00_RS19500	COG0477	Major facilitator Superfamily
K6K00_RS19505	COG1335	isochorismatase
K6K00_RS19515	COG0004	ammonium transporteR
K6K00_RS19520	COG0347	Belongs to the P(II) protein family
K6K00_RS19525	COG0671	phosphoesterase, PA-phosphatase related
K6K00_RS19535	COG0739	heme binding
K6K00_RS19540	COG1247	-acetyltransferase
K6K00_RS19550	COG2089	acid synthase
K6K00_RS19560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6K00_RS19565	COG0789	Transcriptional regulator
K6K00_RS19575	COG2910	NAD(P)H-binding
K6K00_RS19580	COG1959	2 iron, 2 sulfur cluster binding
K6K00_RS19585	COG0804	urea catabolic process
K6K00_RS19590	COG0832	Belongs to the urease beta subunit family
K6K00_RS19595	COG0831	urea catabolic process
K6K00_RS19610	COG3237	CsbD-like
K6K00_RS19615	COG1994	Peptidase M50
K6K00_RS19620	COG0457	Tetratricopeptide repeat
K6K00_RS19625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6K00_RS19630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6K00_RS19640	COG2304	oxidoreductase activity
K6K00_RS19650	COG2304	oxidoreductase activity
K6K00_RS19655	COG2385	sporulation resulting in formation of a cellular spore
K6K00_RS19660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6K00_RS19670	COG4836	Membrane
K6K00_RS19680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K6K00_RS19685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6K00_RS19690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K6K00_RS19695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6K00_RS19700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K6K00_RS19705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K6K00_RS19715	COG0356	it plays a direct role in the translocation of protons across the membrane
K6K00_RS19725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K6K00_RS19730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K6K00_RS19735	COG4475	Protein of unknown function (DUF436)
K6K00_RS19740	COG0698	ribose 5-phosphate isomerase
K6K00_RS19745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6K00_RS19750	COG1971	Probably functions as a manganese efflux pump
K6K00_RS19755	COG0009	L-threonylcarbamoyladenylate synthase
K6K00_RS19760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K6K00_RS19780	COG2890	protein-(glutamine-N5) methyltransferase activity
K6K00_RS19785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6K00_RS19790	COG0346	lactoylglutathione lyase activity
K6K00_RS19795	COG0789	Transcriptional regulator
K6K00_RS19800	COG0679	Auxin Efflux Carrier
K6K00_RS19805	COG0281	malic enzyme
K6K00_RS19810	COG1435	thymidine kinase activity
K6K00_RS19820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K6K00_RS19830	COG1494	fructose-1,6-bisphosphatase
K6K00_RS19835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K6K00_RS19845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K6K00_RS19850	COG0191	fructose-bisphosphate aldolase activity
K6K00_RS19855	COG2204	response regulator
K6K00_RS19860	COG4821	SIS domain
K6K00_RS19865	COG0504	CTP synthase activity
K6K00_RS19870	COG3343	RNA polymerase activity
K6K00_RS19875	COG1960	acyl-CoA dehydrogenase activity
K6K00_RS19880	COG2181	nitrate reductase activity
K6K00_RS19880	COG0247	lactate metabolic process
K6K00_RS19885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6K00_RS19890	COG4294	response to UV
K6K00_RS19900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6K00_RS19910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6K00_RS19920	COG2181	nitrate reductase activity
K6K00_RS19925	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
K6K00_RS19930	COG1140	nitrate reductase beta subunit
K6K00_RS19935	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K6K00_RS19940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6K00_RS19950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6K00_RS19955	COG2223	nitrite transmembrane transporter activity
K6K00_RS19960	COG0018	arginyl-trna synthetase
K6K00_RS19965	COG4506	Protein conserved in bacteria
K6K00_RS19980	COG0535	radical SAM domain protein
K6K00_RS19990	COG1131	(ABC) transporter
K6K00_RS19995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6K00_RS20000	COG0612	Peptidase, M16
K6K00_RS20005	COG0612	Peptidase, M16
K6K00_RS20015	COG3391	amine dehydrogenase activity
K6K00_RS20020	COG3391	amine dehydrogenase activity
K6K00_RS20025	COG0457	Tetratricopeptide repeat
K6K00_RS20040	COG0010	Belongs to the arginase family
K6K00_RS20045	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K6K00_RS20050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6K00_RS20060	COG1994	Peptidase M50
K6K00_RS20065	COG1942	4-Oxalocrotonate Tautomerase
K6K00_RS20070	COG1846	Transcriptional regulator
K6K00_RS20075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6K00_RS20080	COG0477	Major facilitator Superfamily
K6K00_RS20085	COG1959	2 iron, 2 sulfur cluster binding
K6K00_RS20090	COG3465	dGTPase activity
K6K00_RS20095	COG1078	dGTPase activity
K6K00_RS20100	COG4844	belongs to the
K6K00_RS20110	COG0697	spore germination
K6K00_RS20115	COG0095	Lipoate-protein ligase
K6K00_RS20120	COG0583	DNA-binding transcription factor activity
K6K00_RS20125	COG0280	phosphate acetyltransferase
K6K00_RS20130	COG3253	May function as heme-dependent peroxidase
K6K00_RS20135	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS20140	COG0436	Aminotransferase
K6K00_RS20145	COG2814	Major facilitator Superfamily
K6K00_RS20150	COG0151	Belongs to the GarS family
K6K00_RS20155	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS20160	COG1917	Cupin 2, conserved barrel domain protein
K6K00_RS20165	COG0077	Prephenate dehydratase
K6K00_RS20170	COG2814	Major facilitator Superfamily
K6K00_RS20175	COG0833	amino acid
K6K00_RS20180	COG4187	Peptidase family M20/M25/M40
K6K00_RS20185	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS20190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6K00_RS20205	COG1091	dTDP-4-dehydrorhamnose reductase activity
K6K00_RS20210	COG1088	dTDP-glucose 4,6-dehydratase activity
K6K00_RS20215	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6K00_RS20220	COG3980	spore coat polysaccharide biosynthesis protein
K6K00_RS20225	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
K6K00_RS20230	COG2089	acid synthase
K6K00_RS20235	COG0456	acetyltransferase
K6K00_RS20240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6K00_RS20245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K6K00_RS20250	COG0463	Glycosyl transferase, family 2
K6K00_RS20260	COG2363	Small membrane protein
K6K00_RS20265	COG2233	PERMEase
K6K00_RS20275	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS20280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K6K00_RS20285	COG1216	Glycosyl transferase, family 2
K6K00_RS20300	COG1695	Transcriptional regulator
K6K00_RS20305	COG0351	phosphomethylpyrimidine kinase
K6K00_RS20315	COG1621	beta-fructofuranosidase activity
K6K00_RS20320	COG1263	PTS System
K6K00_RS20320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS20325	COG2116	formate transmembrane transporter activity
K6K00_RS20330	COG3711	transcriptional antiterminator
K6K00_RS20340	COG1404	Belongs to the peptidase S8 family
K6K00_RS20345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6K00_RS20350	COG0778	Nitroreductase
K6K00_RS20355	COG0772	Belongs to the SEDS family
K6K00_RS20365	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K6K00_RS20370	COG1845	cytochrome c oxidase, subunit III
K6K00_RS20375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6K00_RS20380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6K00_RS20385	COG2261	transglycosylase associated protein
K6K00_RS20390	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K6K00_RS20395	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K6K00_RS20400	COG2246	polysaccharide biosynthetic process
K6K00_RS20405	COG1309	transcriptional regulator
K6K00_RS20415	COG3162	membrane
K6K00_RS20420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6K00_RS20425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K6K00_RS20430	COG2837	iron assimilation
K6K00_RS20435	COG2822	iron ion transport
K6K00_RS20440	COG0672	)-iron permease
K6K00_RS20445	COG0352	thiamine-phosphate diphosphorylase activity
K6K00_RS20450	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K6K00_RS20455	COG0583	DNA-binding transcription factor activity
K6K00_RS20460	COG1380	Effector of murein hydrolase LrgA
K6K00_RS20465	COG1346	cytolysis
K6K00_RS20470	COG2814	Major facilitator Superfamily
K6K00_RS20475	COG4895	conserved protein (DUF2196)
K6K00_RS20480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6K00_RS20485	COG0346	lactoylglutathione lyase activity
K6K00_RS20505	COG1263	PTS System
K6K00_RS20505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS20510	COG3711	transcriptional antiterminator
K6K00_RS20515	COG1442	glycosyl transferase family 8
K6K00_RS20520	COG5522	Integral membrane protein (intg_mem_TP0381)
K6K00_RS20525	COG1846	Transcriptional regulator
K6K00_RS20530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6K00_RS20535	COG2234	aminopeptidase activity
K6K00_RS20540	COG2357	RelA SpoT domain protein
K6K00_RS20550	COG1575	Belongs to the MenA family. Type 1 subfamily
K6K00_RS20565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS20570	COG1696	Membrane protein involved in D-alanine export
K6K00_RS20575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6K00_RS20580	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K6K00_RS20590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6K00_RS20595	COG1486	melibiose metabolic process
K6K00_RS20600	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6K00_RS20605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6K00_RS20610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6K00_RS20615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6K00_RS20615	COG3711	transcriptional antiterminator
K6K00_RS20625	COG2094	Belongs to the DNA glycosylase MPG family
K6K00_RS20630	COG0753	catalase activity
K6K00_RS20635	COG2814	Major facilitator Superfamily
K6K00_RS20640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K6K00_RS20645	COG1131	(ABC) transporter
K6K00_RS20665	COG1595	DNA-templated transcription, initiation
K6K00_RS20670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K6K00_RS20675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K6K00_RS20680	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6K00_RS20685	COG4988	ABC transporter
K6K00_RS20690	COG1294	oxidase, subunit
K6K00_RS20695	COG1271	oxidase subunit
K6K00_RS20700	COG3493	citrate carrier protein
K6K00_RS20705	COG0501	Belongs to the peptidase M48B family
K6K00_RS20715	COG0726	polysaccharide deacetylase
K6K00_RS20720	COG3842	ATPase activity
K6K00_RS20725	COG2508	Transcriptional regulator
K6K00_RS20730	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS20735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6K00_RS20740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6K00_RS20750	COG4585	Histidine kinase
K6K00_RS20755	COG2197	response regulator
K6K00_RS20760	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6K00_RS20770	COG4894	glucomannan catabolic process
K6K00_RS20775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6K00_RS20780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K6K00_RS20785	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS20790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6K00_RS20795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6K00_RS20800	COG2610	gluconate transmembrane transporter activity
K6K00_RS20805	COG0500	methyltransferase
K6K00_RS20810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6K00_RS20825	COG0753	catalase activity
K6K00_RS20825	COG0693	protein deglycase activity
K6K00_RS20830	COG2851	Citrate transporter
K6K00_RS20835	COG2273	Hydrolase Family 16
K6K00_RS20840	COG3711	transcriptional antiterminator
K6K00_RS20850	COG2270	Major facilitator Superfamily
K6K00_RS20855	COG0513	Belongs to the DEAD box helicase family
K6K00_RS20860	COG2755	lipolytic protein G-D-S-L family
K6K00_RS20860	COG3401	FG-GAP repeat protein
K6K00_RS20985	COG0589	response to stress
K6K00_RS20995	COG1263	PTS System
K6K00_RS20995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS20995	COG2190	(PTS) system
K6K00_RS21010	COG5444	nuclease activity
K6K00_RS21025	COG3507	Belongs to the glycosyl hydrolase 43 family
K6K00_RS21040	COG2986	histidine ammonia-lyase
K6K00_RS21045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K6K00_RS21050	COG1228	amidohydrolase
K6K00_RS21055	COG0010	Belongs to the arginase family
K6K00_RS21060	COG0833	amino acid
K6K00_RS21065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6K00_RS21070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6K00_RS21075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K6K00_RS21080	COG2390	Transcriptional regulator
K6K00_RS21090	COG3192	ethanolamine utilization protein
K6K00_RS21095	COG2079	MmgE PrpD family protein
K6K00_RS21100	COG1473	amidohydrolase
K6K00_RS21105	COG1126	abc transporter atp-binding protein
K6K00_RS21110	COG0765	amino acid transport
K6K00_RS21115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6K00_RS21120	COG0456	acetyltransferase
K6K00_RS21125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6K00_RS21135	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K6K00_RS21140	COG0561	phosphatase activity
K6K00_RS21170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6K00_RS21175	COG5294	Protein conserved in bacteria
K6K00_RS21190	COG2205	protein histidine kinase activity
K6K00_RS21195	COG0745	RESPONSE REGULATOR receiver
K6K00_RS21200	COG0191	fructose-bisphosphate aldolase activity
K6K00_RS21205	COG1082	Xylose isomerase domain protein TIM barrel
K6K00_RS21210	COG1082	Xylose isomerase domain protein TIM barrel
K6K00_RS21215	COG0673	inositol 2-dehydrogenase activity
K6K00_RS21220	COG2814	Major facilitator Superfamily
K6K00_RS21225	COG1082	Xylose isomerase domain protein TIM barrel
K6K00_RS21230	COG3962	Belongs to the TPP enzyme family
K6K00_RS21235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6K00_RS21245	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS21250	COG1349	DNA-binding transcription factor activity
K6K00_RS21255	COG0667	Aldo Keto reductase
K6K00_RS21270	COG2814	Major facilitator Superfamily
K6K00_RS21275	COG0326	Molecular chaperone. Has ATPase activity
K6K00_RS21285	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS21290	COG1309	transcriptional regulator
K6K00_RS21295	COG1012	belongs to the aldehyde dehydrogenase family
K6K00_RS21300	COG0456	acetyltransferase
K6K00_RS21305	COG2850	peptidyl-arginine hydroxylation
K6K00_RS21310	COG2226	methyltransferase
K6K00_RS21325	COG0367	asparagine synthase
K6K00_RS21330	COG2814	Major facilitator Superfamily
K6K00_RS21335	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K6K00_RS21345	COG1714	RDD family
K6K00_RS21350	COG2311	Membrane
K6K00_RS21355	COG1917	Cupin 2, conserved barrel domain protein
K6K00_RS21360	COG1309	transcriptional regulator
K6K00_RS21365	COG1028	Short-chain dehydrogenase reductase Sdr
K6K00_RS21370	COG1846	Transcriptional regulator
K6K00_RS21375	COG1380	Effector of murein hydrolase LrgA
K6K00_RS21380	COG1346	cytolysis
K6K00_RS21385	COG5039	Polysaccharide pyruvyl transferase
K6K00_RS21390	COG1929	Belongs to the glycerate kinase type-1 family
K6K00_RS21395	COG1802	Transcriptional regulator
K6K00_RS21400	COG1070	Carbohydrate kinase
K6K00_RS21405	COG2610	gluconate transmembrane transporter activity
K6K00_RS21410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6K00_RS21415	COG0450	alkyl hydroperoxide reductase
K6K00_RS21420	COG3634	alkyl hydroperoxide reductase activity
K6K00_RS21425	COG2723	6-phospho-beta-galactosidase activity
K6K00_RS21430	COG1263	PTS System
K6K00_RS21430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6K00_RS21430	COG2190	(PTS) system
K6K00_RS21435	COG2188	Transcriptional regulator
K6K00_RS21450	COG1131	(ABC) transporter
K6K00_RS21455	COG1994	Peptidase M50
K6K00_RS21460	COG0535	radical SAM domain protein
K6K00_RS21470	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K6K00_RS21475	COG5293	efflux transmembrane transporter activity
K6K00_RS21485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K6K00_RS21490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K6K00_RS21505	COG1063	alcohol dehydrogenase
K6K00_RS21525	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
K6K00_RS21530	COG0456	acetyltransferase
K6K00_RS21535	COG0457	Tetratricopeptide repeat
K6K00_RS21545	COG0010	Belongs to the arginase family
K6K00_RS21550	COG0833	amino acid
K6K00_RS21555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K6K00_RS21560	COG3829	transcription factor binding
K6K00_RS21575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6K00_RS21580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6K00_RS21585	COG4853	Protein conserved in bacteria
K6K00_RS21590	COG4863	YycH protein
K6K00_RS21595	COG5002	protein histidine kinase activity
K6K00_RS21600	COG0745	RESPONSE REGULATOR receiver
K6K00_RS21630	COG0346	lactoylglutathione lyase activity
K6K00_RS21635	COG0305	Participates in initiation and elongation during chromosome replication
K6K00_RS21650	COG3093	addiction module antidote protein HigA
K6K00_RS21655	COG2807	transmembrane transport
K6K00_RS21660	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K6K00_RS21665	COG0359	binds to the 23S rRNA
K6K00_RS21670	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
K6K00_RS21675	COG4241	membrane
K6K00_RS21690	COG1733	regulation of RNA biosynthetic process
K6K00_RS21695	COG1227	inorganic diphosphatase activity
K6K00_RS21710	COG2271	Major facilitator Superfamily
K6K00_RS21715	COG4978	Transcriptional regulator
K6K00_RS21715	COG0789	Transcriptional regulator
K6K00_RS21725	COG4319	ketosteroid isomerase
K6K00_RS21730	COG1357	PFAM Pentapeptide repeats (8 copies)
K6K00_RS21735	COG2814	Major facilitator Superfamily
K6K00_RS21740	COG0583	DNA-binding transcription factor activity
K6K00_RS21745	COG2153	protein acetylation
K6K00_RS21755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6K00_RS21760	COG1846	Transcriptional regulator
K6K00_RS21765	COG2153	protein acetylation
K6K00_RS21770	COG2364	Membrane
K6K00_RS21775	COG0456	acetyltransferase
K6K00_RS21780	COG2315	Protein conserved in bacteria
K6K00_RS21785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6K00_RS21795	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K6K00_RS21800	COG1331	Highly conserved protein containing a thioredoxin domain
K6K00_RS21805	COG1266	CAAX protease self-immunity
K6K00_RS21810	COG0477	Major facilitator Superfamily
K6K00_RS21810	COG2814	Major facilitator Superfamily
K6K00_RS21815	COG0346	lactoylglutathione lyase activity
K6K00_RS21820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6K00_RS21825	COG0542	response to heat
K6K00_RS21840	COG0708	Exodeoxyribonuclease III
K6K00_RS21845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K6K00_RS21850	COG0629	single-stranded DNA binding
K6K00_RS21855	COG0360	Binds together with S18 to 16S ribosomal RNA
K6K00_RS21860	COG0012	GTP binding
K6K00_RS21865	COG0243	molybdopterin cofactor binding
K6K00_RS21870	COG4481	Protein conserved in bacteria
K6K00_RS21875	COG3949	Membrane
K6K00_RS21885	COG1475	DNA binding
K6K00_RS21890	COG1192	Involved in chromosome partitioning
K6K00_RS21900	COG1475	DNA binding
K6K00_RS21905	COG0357	Ribosomal RNA small subunit methyltransferase G
K6K00_RS21910	COG0445	tRNA wobble uridine modification
K6K00_RS21915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K6K00_RS21920	COG1847	R3H domain protein
K6K00_RS21925	COG0706	membrane insertase activity
K6K00_RS21930	COG0594	ribonuclease P activity
K6K00_RS21960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6K00_RS21990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6K00_RS22105	COG0697	spore germination