locus-tag	class	description
BEST7003_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BEST7003_RS00010	COG0592	DNA-directed DNA polymerase activity
BEST7003_RS00015	COG2501	S4 domain
BEST7003_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BEST7003_RS00030	COG0187	DNA topoisomerase II activity
BEST7003_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BEST7003_RS00070	COG0516	GMP reductase activity
BEST7003_RS00070	COG0517	IMP dehydrogenase activity
BEST7003_RS00075	COG1686	Belongs to the peptidase S11 family
BEST7003_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BEST7003_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BEST7003_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BEST7003_RS00100	COG1428	Deoxynucleoside kinase
BEST7003_RS00105	COG1428	Deoxynucleoside kinase
BEST7003_RS00110	COG3858	chitin binding
BEST7003_RS00110	COG1388	LysM domain
BEST7003_RS00115	COG1335	isochorismatase
BEST7003_RS00120	COG0590	tRNA wobble adenosine to inosine editing
BEST7003_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BEST7003_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BEST7003_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BEST7003_RS00180	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BEST7003_RS00185	COG3853	Toxic anion resistance protein (TelA)
BEST7003_RS00190	COG1982	Orn Lys Arg decarboxylase major
BEST7003_RS00195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BEST7003_RS00200	COG3870	Protein conserved in bacteria
BEST7003_RS00205	COG1728	Protein conserved in bacteria
BEST7003_RS00210	COG0470	DNA polymerase III
BEST7003_RS00215	COG1774	PSP1 C-terminal conserved region
BEST7003_RS00220	COG4467	Involved in initiation control of chromosome replication
BEST7003_RS00225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BEST7003_RS00230	COG2827	Endonuclease containing a URI domain
BEST7003_RS00235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BEST7003_RS00240	COG2002	toxin-antitoxin pair type II binding
BEST7003_RS00245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_RS00245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_RS00250	COG0084	hydrolase, TatD family'
BEST7003_RS00255	COG3584	3D domain protein
BEST7003_RS00255	COG3583	domain protein
BEST7003_RS00260	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BEST7003_RS00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BEST7003_RS00275	COG4466	Protein conserved in bacteria
BEST7003_RS00285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BEST7003_RS00290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7003_RS00295	COG0251	oxidation-reduction process
BEST7003_RS00300	COG2088	sporulation resulting in formation of a cellular spore
BEST7003_RS00305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BEST7003_RS00310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BEST7003_RS00315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BEST7003_RS00320	COG0193	aminoacyl-tRNA hydrolase activity
BEST7003_RS00330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BEST7003_RS00335	COG2002	toxin-antitoxin pair type II binding
BEST7003_RS00340	COG2244	polysaccharide biosynthetic process
BEST7003_RS00345	COG3956	TIGRFAM MazG family protein
BEST7003_RS00350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BEST7003_RS00365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BEST7003_RS00370	COG1098	S1 RNA binding domain
BEST7003_RS00385	COG2208	phosphoserine phosphatase activity
BEST7003_RS00390	COG2304	oxidoreductase activity
BEST7003_RS00395	COG0515	serine threonine protein kinase
BEST7003_RS00400	COG0037	tRNA processing
BEST7003_RS00405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BEST7003_RS00410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7003_RS00415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BEST7003_RS00420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BEST7003_RS00425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BEST7003_RS00430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7003_RS00435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BEST7003_RS00440	COG0512	Glutamine amidotransferase of anthranilate synthase
BEST7003_RS00445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7003_RS00450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BEST7003_RS00455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BEST7003_RS00460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BEST7003_RS00465	COG1396	sequence-specific DNA binding
BEST7003_RS00470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BEST7003_RS00475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BEST7003_RS00555	COG4463	regulation of RNA biosynthetic process
BEST7003_RS00560	COG3880	PFAM UvrB UvrC protein
BEST7003_RS00565	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BEST7003_RS00570	COG0542	response to heat
BEST7003_RS00575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BEST7003_RS00580	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BEST7003_RS00585	COG4956	integral membrane protein (PIN domain superfamily)
BEST7003_RS00590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BEST7003_RS00595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BEST7003_RS00600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BEST7003_RS00610	COG1045	serine acetyltransferase
BEST7003_RS00615	COG0215	cysteine-tRNA ligase activity
BEST7003_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BEST7003_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BEST7003_RS00630	COG3688	RNA-binding protein containing a PIN domain
BEST7003_RS00635	COG1595	DNA-templated transcription, initiation
BEST7003_RS00640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BEST7003_RS00645	COG0250	Participates in transcription elongation, termination and antitermination
BEST7003_RS00655	COG0081	regulation of translation
BEST7003_RS00660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BEST7003_RS00670	COG2813	Specifically methylates the guanine in position
BEST7003_RS00675	COG0085	RNA polymerase activity
BEST7003_RS00680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BEST7003_RS00685	COG1358	cellular component organization or biogenesis
BEST7003_RS00690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BEST7003_RS00695	COG0049	tRNA binding
BEST7003_RS00700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BEST7003_RS00705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BEST7003_RS00710	COG0596	Alpha beta hydrolase
BEST7003_RS00720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BEST7003_RS00725	COG0088	Forms part of the polypeptide exit tunnel
BEST7003_RS00735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BEST7003_RS00750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BEST7003_RS00755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BEST7003_RS00765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BEST7003_RS00770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BEST7003_RS00780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BEST7003_RS00790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BEST7003_RS00795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BEST7003_RS00800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BEST7003_RS00805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BEST7003_RS00815	COG0200	Binds to the 23S rRNA
BEST7003_RS00820	COG0201	protein transport
BEST7003_RS00825	COG0563	adenylate kinase activity
BEST7003_RS00830	COG0024	Methionine aminopeptidase
BEST7003_RS00835	COG2163	COG2163 Ribosomal protein L14E L6E L27E
BEST7003_RS00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BEST7003_RS00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BEST7003_RS00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BEST7003_RS00860	COG0202	RNA polymerase activity
BEST7003_RS00865	COG0203	ribosomal protein L17
BEST7003_RS00870	COG1122	ATPase activity
BEST7003_RS00875	COG1122	ATPase activity
BEST7003_RS00880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BEST7003_RS00885	COG0101	tRNA pseudouridine synthase activity
BEST7003_RS00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BEST7003_RS00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BEST7003_RS00900	COG2226	methyltransferase
BEST7003_RS00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS00915	COG0489	protein tyrosine kinase activity
BEST7003_RS00925	COG2194	sulfuric ester hydrolase activity
BEST7003_RS00930	COG0726	polysaccharide deacetylase
BEST7003_RS01010	COG0659	secondary active sulfate transmembrane transporter activity
BEST7003_RS01015	COG0385	Bile acid
BEST7003_RS01020	COG2819	hydrolase of the alpha beta superfamily
BEST7003_RS01025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS01035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_RS01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_RS01040	COG2207	Transcriptional regulator
BEST7003_RS01045	COG3876	Protein conserved in bacteria
BEST7003_RS01050	COG1472	Belongs to the glycosyl hydrolase 3 family
BEST7003_RS01055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BEST7003_RS01060	COG1263	PTS System
BEST7003_RS01060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS01065	COG1737	Transcriptional regulator
BEST7003_RS01070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BEST7003_RS01075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_RS01080	COG1683	Conserved Protein
BEST7003_RS01110	COG1595	DNA-templated transcription, initiation
BEST7003_RS01115	COG5662	AntiSigma factor
BEST7003_RS01120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BEST7003_RS01125	COG4856	YbbR-like protein
BEST7003_RS01130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BEST7003_RS01135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BEST7003_RS01140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BEST7003_RS01145	COG2169	Transcriptional regulator
BEST7003_RS01150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BEST7003_RS01155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BEST7003_RS01160	COG3002	Belongs to the UPF0753 family
BEST7003_RS01165	COG0288	reversible hydration of carbon dioxide
BEST7003_RS01175	COG5609	conserved protein (DUF2294)
BEST7003_RS01180	COG0640	Transcriptional regulator
BEST7003_RS01185	COG2814	Major facilitator Superfamily
BEST7003_RS01190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BEST7003_RS01200	COG0535	radical SAM domain protein
BEST7003_RS01205	COG1266	CAAX protease self-immunity
BEST7003_RS01210	COG1131	(ABC) transporter
BEST7003_RS01220	COG1413	lyase activity
BEST7003_RS01225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS01230	COG0596	Alpha beta hydrolase
BEST7003_RS01235	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS01240	COG0642	Histidine kinase
BEST7003_RS01250	COG0515	serine threonine protein kinase
BEST7003_RS01265	COG1113	amino acid transport
BEST7003_RS01280	COG2602	Beta-lactamase
BEST7003_RS01285	COG2124	cytochrome p450
BEST7003_RS01295	COG0531	amino acid
BEST7003_RS01300	COG0584	glycerophosphoryl diester phosphodiesterase
BEST7003_RS01305	COG2271	Major facilitator Superfamily
BEST7003_RS01315	COG0456	acetyltransferase
BEST7003_RS01315	COG1846	Transcriptional regulator
BEST7003_RS01320	COG2271	Major facilitator Superfamily
BEST7003_RS01330	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS01335	COG0697	spore germination
BEST7003_RS01340	COG2207	Transcriptional regulator
BEST7003_RS01340	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_RS01345	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BEST7003_RS01350	COG3591	Belongs to the peptidase S1B family
BEST7003_RS01360	COG0596	Alpha beta hydrolase
BEST7003_RS01365	COG1183	phosphatidylcholine synthase activity
BEST7003_RS01370	COG0586	Pfam SNARE associated Golgi protein
BEST7003_RS01375	COG0688	phosphatidylethanolamine metabolic process
BEST7003_RS01385	COG2312	Erythromycin esterase
BEST7003_RS01390	COG2207	Transcriptional regulator
BEST7003_RS01395	COG1054	Belongs to the UPF0176 family
BEST7003_RS01400	COG1301	dicarboxylic acid transport
BEST7003_RS01405	COG2190	(PTS) system
BEST7003_RS01405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS01405	COG1263	PTS System
BEST7003_RS01410	COG0363	glucosamine-6-phosphate deaminase activity
BEST7003_RS01415	COG2188	Transcriptional regulator
BEST7003_RS01425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7003_RS01430	COG0833	amino acid
BEST7003_RS01435	COG2040	homocysteine
BEST7003_RS01445	COG1115	amino acid carrier protein
BEST7003_RS01450	COG2066	Belongs to the glutaminase family
BEST7003_RS01455	COG4191	Histidine kinase
BEST7003_RS01460	COG0784	Response regulator, receiver
BEST7003_RS01465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BEST7003_RS01470	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS01475	COG2271	Major facilitator Superfamily
BEST7003_RS01480	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7003_RS01485	COG2186	Transcriptional regulator
BEST7003_RS01490	COG2721	sulfolactate sulfo-lyase activity
BEST7003_RS01495	COG3173	Aminoglycoside phosphotransferase
BEST7003_RS01505	COG0697	spore germination
BEST7003_RS01510	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS01515	COG2205	protein histidine kinase activity
BEST7003_RS01520	COG1131	(ABC) transporter
BEST7003_RS01535	COG3773	Cell wall hydrolase
BEST7003_RS01540	COG2304	oxidoreductase activity
BEST7003_RS01545	COG3540	Alkaline phosphatase
BEST7003_RS01550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7003_RS01555	COG0805	protein transport
BEST7003_RS01560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BEST7003_RS01565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BEST7003_RS01570	COG0477	Major facilitator Superfamily
BEST7003_RS01575	COG1309	transcriptional regulator
BEST7003_RS01580	COG0252	asparaginase activity
BEST7003_RS01585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BEST7003_RS01590	COG1714	RDD family
BEST7003_RS01595	COG3012	SEC-C Motif Domain Protein
BEST7003_RS01595	COG1405	negative regulation of cell septum assembly
BEST7003_RS01600	COG3290	protein histidine kinase activity
BEST7003_RS01605	COG3279	Response regulator of the LytR AlgR family
BEST7003_RS01610	COG4555	ABC transporter
BEST7003_RS01615	COG1668	transmembrane transport
BEST7003_RS01620	COG0667	Aldo Keto reductase
BEST7003_RS01630	COG1595	DNA-templated transcription, initiation
BEST7003_RS01635	COG1595	DNA-templated transcription, initiation
BEST7003_RS01640	COG1876	peptidase activity
BEST7003_RS01645	COG0457	Tetratricopeptide repeat
BEST7003_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS01655	COG0366	Alpha amylase catalytic
BEST7003_RS01660	COG0803	Belongs to the bacterial solute-binding protein 9 family
BEST7003_RS01665	COG1121	(ABC) transporter
BEST7003_RS01670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7003_RS01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_RS01680	COG2310	stress, protein
BEST7003_RS01685	COG2310	stress, protein
BEST7003_RS01690	COG2310	stress, protein
BEST7003_RS01695	COG0861	Integral membrane protein TerC family
BEST7003_RS01705	COG3853	Toxic anion resistance protein (TelA)
BEST7003_RS01710	COG0477	Major facilitator Superfamily
BEST7003_RS01715	COG2814	Major facilitator Superfamily
BEST7003_RS01720	COG0640	Transcriptional regulator
BEST7003_RS01725	COG0517	IMP dehydrogenase activity
BEST7003_RS01725	COG4175	Glycine betaine
BEST7003_RS01730	COG4176	ABC-type proline glycine betaine transport system permease component
BEST7003_RS01735	COG2113	Glycine betaine
BEST7003_RS01740	COG1473	amidohydrolase
BEST7003_RS01745	COG1288	antiporter activity
BEST7003_RS01755	COG0366	Alpha amylase catalytic
BEST7003_RS01760	COG0039	L-malate dehydrogenase activity
BEST7003_RS01765	COG1620	l-lactate permease
BEST7003_RS01770	COG2814	Major facilitator Superfamily
BEST7003_RS01775	COG1846	Transcriptional regulator
BEST7003_RS01780	COG1280	lysine exporter protein (LysE YggA)
BEST7003_RS01785	COG3403	YqcI/YcgG family
BEST7003_RS01790	COG1113	amino acid transport
BEST7003_RS01795	COG3665	Urea carboxylase-associated protein
BEST7003_RS01800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BEST7003_RS01805	COG1660	Displays ATPase and GTPase activities
BEST7003_RS01810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BEST7003_RS01815	COG2226	methyltransferase
BEST7003_RS01820	COG0583	DNA-binding transcription factor activity
BEST7003_RS01825	COG3458	cephalosporin-C deacetylase activity
BEST7003_RS01830	COG3541	Predicted nucleotidyltransferase
BEST7003_RS01835	COG0506	proline dehydrogenase activity
BEST7003_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS01845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_RS01850	COG2508	Transcriptional regulator
BEST7003_RS01855	COG3689	TIGRFAM TIGR03943 family protein
BEST7003_RS01860	COG0701	Predicted permease
BEST7003_RS01865	COG2267	carboxylic ester hydrolase activity
BEST7003_RS01870	COG0492	ferredoxin-NADP+ reductase activity
BEST7003_RS01875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BEST7003_RS01875	COG1587	Uroporphyrinogen-III synthase
BEST7003_RS01880	COG2146	nitrite reductase [NAD(P)H] activity
BEST7003_RS01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7003_RS01890	COG0243	molybdopterin cofactor binding
BEST7003_RS01895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7003_RS01900	COG2223	nitrite transmembrane transporter activity
BEST7003_RS01905	COG1469	GTP cyclohydrolase I activity
BEST7003_RS01910	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7003_RS01915	COG0523	cobalamin synthesis protein
BEST7003_RS01920	COG0765	amino acid transport
BEST7003_RS01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_RS01930	COG1714	RDD family
BEST7003_RS01940	COG2723	6-phospho-beta-galactosidase activity
BEST7003_RS01950	COG3209	COG3209 Rhs family protein
BEST7003_RS01955	COG0840	transmembrane signaling receptor activity
BEST7003_RS01955	COG3290	protein histidine kinase activity
BEST7003_RS01960	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BEST7003_RS01965	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BEST7003_RS01970	COG1733	regulation of RNA biosynthetic process
BEST7003_RS01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_RS01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_RS01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_RS01990	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BEST7003_RS01995	COG2814	Major facilitator Superfamily
BEST7003_RS02005	COG0697	spore germination
BEST7003_RS02010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_RS02020	COG2364	Membrane
BEST7003_RS02025	COG1126	abc transporter atp-binding protein
BEST7003_RS02030	COG0765	amino acid transport
BEST7003_RS02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_RS02040	COG0583	DNA-binding transcription factor activity
BEST7003_RS02045	COG0163	prenyltransferase activity
BEST7003_RS02050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BEST7003_RS02065	COG0596	Alpha beta hydrolase
BEST7003_RS02070	COG3104	oligopeptide transport
BEST7003_RS02075	COG5434	Belongs to the glycosyl hydrolase 28 family
BEST7003_RS02085	COG0697	spore germination
BEST7003_RS02095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BEST7003_RS02100	COG1136	(ABC) transporter
BEST7003_RS02105	COG0577	efflux transmembrane transporter activity
BEST7003_RS02110	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS02115	COG5002	protein histidine kinase activity
BEST7003_RS02115	COG3850	Histidine kinase
BEST7003_RS02120	COG0457	Tetratricopeptide repeat
BEST7003_RS02140	COG0527	aspartate kinase activity
BEST7003_RS02145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS02150	COG4605	iron ion homeostasis
BEST7003_RS02155	COG4604	ABC transporter, ATP-binding protein
BEST7003_RS02160	COG4607	ABC-type enterochelin transport system periplasmic component
BEST7003_RS02165	COG2814	Major facilitator Superfamily
BEST7003_RS02170	COG1309	transcriptional regulator
BEST7003_RS02175	COG0778	Nitroreductase
BEST7003_RS02180	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BEST7003_RS02185	COG0640	Transcriptional regulator
BEST7003_RS02190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_RS02195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BEST7003_RS02200	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS02205	COG4975	Glucose uptake
BEST7003_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS02215	COG4549	nuclear export factor GLE1
BEST7003_RS02220	COG2372	response to copper ion
BEST7003_RS02220	COG1276	copper resistance
BEST7003_RS02225	COG1349	DNA-binding transcription factor activity
BEST7003_RS02235	COG2213	PTS system mannitol-specific
BEST7003_RS02240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_RS02245	COG0246	Mannitol dehydrogenase
BEST7003_RS02250	COG0473	3-isopropylmalate dehydrogenase activity
BEST7003_RS02255	COG0681	Belongs to the peptidase S26 family
BEST7003_RS02260	COG0412	Dienelactone hydrolase
BEST7003_RS02265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BEST7003_RS02270	COG0561	phosphatase activity
BEST7003_RS02275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BEST7003_RS02280	COG1914	H( )-stimulated, divalent metal cation uptake system
BEST7003_RS02285	COG4336	lyase activity
BEST7003_RS02290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BEST7003_RS02295	COG1984	allophanate hydrolase subunit 2
BEST7003_RS02300	COG1414	Transcriptional regulator
BEST7003_RS02305	COG2755	lipolytic protein G-D-S-L family
BEST7003_RS02315	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_RS02320	COG0768	penicillin binding
BEST7003_RS02325	COG4989	oxidoreductase activity
BEST7003_RS02330	COG3711	transcriptional antiterminator
BEST7003_RS02335	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_RS02340	COG2226	methyltransferase
BEST7003_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS02350	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_RS02355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_RS02360	COG3871	stress protein (general stress protein 26)
BEST7003_RS02370	COG2814	Major facilitator Superfamily
BEST7003_RS02375	COG1522	sequence-specific DNA binding
BEST7003_RS02380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BEST7003_RS02380	COG0551	DNA topoisomerase type I activity
BEST7003_RS02385	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BEST7003_RS02390	COG3706	GGDEF domain
BEST7003_RS02395	COG5298	Protein conserved in bacteria
BEST7003_RS02400	COG1215	transferase activity, transferring glycosyl groups
BEST7003_RS02410	COG0531	amino acid
BEST7003_RS02415	COG0494	nUDIX hydrolase
BEST7003_RS02420	COG0028	Belongs to the TPP enzyme family
BEST7003_RS02435	COG1914	H( )-stimulated, divalent metal cation uptake system
BEST7003_RS02440	COG2261	transglycosylase associated protein
BEST7003_RS02445	COG4876	unkown
BEST7003_RS02450	COG2217	Heavy metal translocating P-type atpase
BEST7003_RS02455	COG3729	General stress protein
BEST7003_RS02460	COG0662	Cupin 2, conserved barrel domain protein
BEST7003_RS02465	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_RS02470	COG3546	catalase activity
BEST7003_RS02475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BEST7003_RS02480	COG3290	protein histidine kinase activity
BEST7003_RS02485	COG4565	transcriptional regulatory protein
BEST7003_RS02490	COG1301	dicarboxylic acid transport
BEST7003_RS02495	COG0628	permease
BEST7003_RS02500	COG1131	(ABC) transporter
BEST7003_RS02505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BEST7003_RS02515	COG1960	acyl-CoA dehydrogenase activity
BEST7003_RS02520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7003_RS02525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS02530	COG1181	Belongs to the D-alanine--D-alanine ligase family
BEST7003_RS02535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BEST7003_RS02540	COG0513	Belongs to the DEAD box helicase family
BEST7003_RS02545	COG3402	PFAM membrane-flanked domain
BEST7003_RS02550	COG3428	Bacterial PH domain
BEST7003_RS02555	COG0705	Rhomboid family
BEST7003_RS02560	COG0736	holo-[acyl-carrier-protein] synthase activity
BEST7003_RS02565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BEST7003_RS02570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BEST7003_RS02575	COG0864	Transcriptional regulator
BEST7003_RS02580	COG2337	Toxic component of a toxin-antitoxin (TA) module
BEST7003_RS02585	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_RS02590	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_RS02595	COG2172	sigma factor antagonist activity
BEST7003_RS02600	COG2208	phosphoserine phosphatase activity
BEST7003_RS02605	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_RS02610	COG2172	sigma factor antagonist activity
BEST7003_RS02615	COG1191	sigma factor activity
BEST7003_RS02620	COG2208	phosphoserine phosphatase activity
BEST7003_RS02625	COG1673	EVE domain
BEST7003_RS02630	COG1846	Transcriptional regulator
BEST7003_RS02635	COG2183	response to ionizing radiation
BEST7003_RS02640	COG3091	SprT-like family
BEST7003_RS02680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_RS02685	COG1522	sequence-specific DNA binding
BEST7003_RS02690	COG1522	sequence-specific DNA binding
BEST7003_RS02695	COG1335	isochorismatase
BEST7003_RS02700	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BEST7003_RS02705	COG2814	Major facilitator Superfamily
BEST7003_RS02725	COG0693	protein deglycase activity
BEST7003_RS02730	COG1278	Cold shock
BEST7003_RS02735	COG1329	Transcriptional regulator
BEST7003_RS02740	COG0697	spore germination
BEST7003_RS02745	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_RS02745	COG2207	Transcriptional regulator
BEST7003_RS02750	COG0697	spore germination
BEST7003_RS02755	COG2207	Transcriptional regulator
BEST7003_RS02755	COG3708	Transcriptional regulator
BEST7003_RS02760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_RS02765	COG0477	Major facilitator Superfamily
BEST7003_RS02775	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BEST7003_RS02785	COG0697	spore germination
BEST7003_RS02790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_RS02795	COG2030	dehydratase
BEST7003_RS02800	COG3545	Serine hydrolase
BEST7003_RS02805	COG1733	regulation of RNA biosynthetic process
BEST7003_RS02810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_RS02815	COG1733	regulation of RNA biosynthetic process
BEST7003_RS02820	COG2249	NAD(P)H dehydrogenase (quinone) activity
BEST7003_RS02825	COG2814	Major facilitator Superfamily
BEST7003_RS02830	COG1309	transcriptional regulator
BEST7003_RS02835	COG0640	Transcriptional regulator
BEST7003_RS02840	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BEST7003_RS02845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_RS02850	COG0697	spore germination
BEST7003_RS02855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_RS02860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7003_RS02865	COG0640	Transcriptional regulator
BEST7003_RS02870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BEST7003_RS02880	COG4585	Histidine kinase
BEST7003_RS02885	COG2197	response regulator
BEST7003_RS02890	COG2409	Drug exporters of the RND superfamily
BEST7003_RS02895	COG0596	Alpha beta hydrolase
BEST7003_RS02900	COG1811	Na channel or pump
BEST7003_RS02905	COG0789	Transcriptional regulator
BEST7003_RS02905	COG4978	Transcriptional regulator
BEST7003_RS02910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7003_RS02915	COG0778	Nitroreductase
BEST7003_RS02920	COG0346	lactoylglutathione lyase activity
BEST7003_RS02925	COG2259	Doxx family
BEST7003_RS02930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS02945	COG2323	membrane
BEST7003_RS02950	COG2323	membrane
BEST7003_RS02955	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7003_RS02970	COG1309	transcriptional regulator
BEST7003_RS02980	COG0456	acetyltransferase
BEST7003_RS02985	COG0488	(ABC) transporter
BEST7003_RS02990	COG1113	amino acid transport
BEST7003_RS02995	COG2318	DinB family
BEST7003_RS03000	COG1846	Transcriptional regulator
BEST7003_RS03005	COG1033	growth of symbiont in host cell
BEST7003_RS03005	COG2409	Drug exporters of the RND superfamily
BEST7003_RS03010	COG0778	Nitroreductase
BEST7003_RS03015	COG1846	Transcriptional regulator
BEST7003_RS03020	COG2814	Major facilitator Superfamily
BEST7003_RS03025	COG0730	response to heat
BEST7003_RS03030	COG1802	Transcriptional regulator
BEST7003_RS03035	COG1388	LysM domain
BEST7003_RS03035	COG3858	chitin binding
BEST7003_RS03040	COG1819	glycosyl
BEST7003_RS03050	COG1785	Belongs to the alkaline phosphatase family
BEST7003_RS03055	COG5646	InterPro IPR014922
BEST7003_RS03065	COG0454	-acetyltransferase
BEST7003_RS03070	COG1078	dGTPase activity
BEST7003_RS03075	COG1388	LysM domain
BEST7003_RS03080	COG2814	Major facilitator Superfamily
BEST7003_RS03085	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_RS03090	COG1447	Phosphotransferase system cellobiose-specific component IIA
BEST7003_RS03095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_RS03100	COG2723	6-phospho-beta-galactosidase activity
BEST7003_RS03105	COG2188	Transcriptional regulator
BEST7003_RS03110	COG1940	carbohydrate kinase activity
BEST7003_RS03115	COG1482	cell wall glycoprotein biosynthetic process
BEST7003_RS03120	COG4124	Belongs to the glycosyl hydrolase 26 family
BEST7003_RS03170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BEST7003_RS03175	COG0802	atpase or kinase
BEST7003_RS03180	COG1214	PFAM Peptidase M22, glycoprotease
BEST7003_RS03185	COG0456	acetyltransferase
BEST7003_RS03190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BEST7003_RS03195	COG0488	(ABC) transporter
BEST7003_RS03200	COG0315	cyclic pyranopterin monophosphate synthase activity
BEST7003_RS03205	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BEST7003_RS03210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7003_RS03215	COG0805	protein transport
BEST7003_RS03225	COG1266	CAAX protease self-immunity
BEST7003_RS03250	COG0457	Tetratricopeptide repeat
BEST7003_RS03255	COG1063	alcohol dehydrogenase
BEST7003_RS03260	COG2211	Major facilitator Superfamily
BEST7003_RS03265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_RS03275	COG1842	Phage shock protein A
BEST7003_RS03280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BEST7003_RS03285	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BEST7003_RS03290	COG4260	virion core protein, lumpy skin disease virus
BEST7003_RS03295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BEST7003_RS03295	COG2755	lipolytic protein G-D-S-L family
BEST7003_RS03305	COG1595	DNA-templated transcription, initiation
BEST7003_RS03310	COG1063	alcohol dehydrogenase
BEST7003_RS03315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BEST7003_RS03320	COG0823	Involved in the tonB-independent uptake of proteins
BEST7003_RS03335	COG2132	Multicopper oxidase
BEST7003_RS03340	COG1113	amino acid transport
BEST7003_RS03345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7003_RS03350	COG0714	Associated with various cellular activities
BEST7003_RS03355	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BEST7003_RS03360	COG1305	Transglutaminase-like
BEST7003_RS03370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7003_RS03390	COG2211	Major facilitator Superfamily
BEST7003_RS03405	COG2252	PERMEase
BEST7003_RS03410	COG3064	Membrane
BEST7003_RS03425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BEST7003_RS03430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BEST7003_RS03435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BEST7003_RS03440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BEST7003_RS03445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BEST7003_RS03460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BEST7003_RS03465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BEST7003_RS03470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BEST7003_RS03475	COG0138	bifunctional purine biosynthesis protein purh
BEST7003_RS03480	COG0151	Belongs to the GarS family
BEST7003_RS03485	COG1522	sequence-specific DNA binding
BEST7003_RS03490	COG0531	amino acid
BEST7003_RS03500	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BEST7003_RS03505	COG1470	cell adhesion involved in biofilm formation
BEST7003_RS03510	COG4496	protein, YerC YecD
BEST7003_RS03515	COG0069	glutamate synthase activity
BEST7003_RS03520	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BEST7003_RS03525	COG0210	DNA helicase
BEST7003_RS03530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BEST7003_RS03535	COG4851	CamS sex pheromone cAM373 precursor
BEST7003_RS03540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_RS03545	COG1285	pathogenesis
BEST7003_RS03550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_RS03555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BEST7003_RS03560	COG0154	amidase activity
BEST7003_RS03565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BEST7003_RS03570	COG1309	transcriptional regulator
BEST7003_RS03575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BEST7003_RS03580	COG1597	lipid kinase activity
BEST7003_RS03585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BEST7003_RS03590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7003_RS03595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7003_RS03600	COG1002	Type II restriction enzyme, methylase subunits
BEST7003_RS03605	COG1061	Type III restriction enzyme res subunit
BEST7003_RS03610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BEST7003_RS03630	COG5444	nuclease activity
BEST7003_RS03635	COG3391	amine dehydrogenase activity
BEST7003_RS03640	COG0457	Tetratricopeptide repeat
BEST7003_RS03650	COG0217	transcriptional regulatory protein
BEST7003_RS03660	COG1309	transcriptional regulator
BEST7003_RS03665	COG3631	Ketosteroid isomerase-related protein
BEST7003_RS03670	COG0702	epimerase
BEST7003_RS03685	COG3546	catalase activity
BEST7003_RS03690	COG0454	-acetyltransferase
BEST7003_RS03700	COG5578	integral membrane protein
BEST7003_RS03705	COG2972	Histidine kinase
BEST7003_RS03710	COG4753	response regulator
BEST7003_RS03710	COG2207	Transcriptional regulator
BEST7003_RS03715	COG1653	transport
BEST7003_RS03720	COG1175	transmembrane transport
BEST7003_RS03725	COG0395	ABC-type sugar transport system, permease component
BEST7003_RS03730	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BEST7003_RS03735	COG2207	Transcriptional regulator
BEST7003_RS03740	COG2755	lipolytic protein G-D-S-L family
BEST7003_RS03750	COG5578	integral membrane protein
BEST7003_RS03755	COG3401	FG-GAP repeat protein
BEST7003_RS03760	COG3401	FG-GAP repeat protein
BEST7003_RS03765	COG2755	lipolytic protein G-D-S-L family
BEST7003_RS03770	COG1874	Beta-galactosidase
BEST7003_RS03780	COG1653	transport
BEST7003_RS03785	COG4209	transmembrane transport
BEST7003_RS03790	COG0395	ABC-type sugar transport system, permease component
BEST7003_RS03795	COG1486	melibiose metabolic process
BEST7003_RS03800	COG2323	membrane
BEST7003_RS03805	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_RS03810	COG0346	lactoylglutathione lyase activity
BEST7003_RS03825	COG0670	Belongs to the BI1 family
BEST7003_RS03830	COG0697	spore germination
BEST7003_RS03835	COG1846	Transcriptional regulator
BEST7003_RS03840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BEST7003_RS03850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7003_RS03850	COG2124	cytochrome p450
BEST7003_RS03855	COG1368	sulfuric ester hydrolase activity
BEST7003_RS03860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BEST7003_RS03865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7003_RS03870	COG1442	glycosyl transferase family 8
BEST7003_RS03875	COG1216	Glycosyl transferase, family 2
BEST7003_RS03880	COG1442	glycosyl transferase family 8
BEST7003_RS03885	COG2223	nitrite transmembrane transporter activity
BEST7003_RS03890	COG1011	Hydrolase
BEST7003_RS03895	COG0531	amino acid
BEST7003_RS03900	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS03905	COG0840	transmembrane signaling receptor activity
BEST7003_RS03910	COG0488	(ABC) transporter
BEST7003_RS03920	COG0789	Transcriptional regulator
BEST7003_RS03925	COG2814	Major facilitator Superfamily
BEST7003_RS03935	COG0488	(ABC) transporter
BEST7003_RS03940	COG0513	Belongs to the DEAD box helicase family
BEST7003_RS03945	COG0456	acetyltransferase
BEST7003_RS03950	COG2130	NADP-dependent
BEST7003_RS03960	COG2211	Major facilitator Superfamily
BEST7003_RS03965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BEST7003_RS03970	COG1120	ATPase activity
BEST7003_RS03975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS03980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS03985	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BEST7003_RS04000	COG3866	Pectate lyase
BEST7003_RS04005	COG0471	metal ion transport
BEST7003_RS04010	COG3290	protein histidine kinase activity
BEST7003_RS04015	COG4565	transcriptional regulatory protein
BEST7003_RS04020	COG3181	Tripartite tricarboxylate transporter family receptor
BEST7003_RS04025	COG2851	Citrate transporter
BEST7003_RS04030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_RS04035	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BEST7003_RS04040	COG1254	Belongs to the acylphosphatase family
BEST7003_RS04045	COG2258	MOSC domain
BEST7003_RS04055	COG0024	Methionine aminopeptidase
BEST7003_RS04060	COG1263	PTS System
BEST7003_RS04060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS04065	COG1368	sulfuric ester hydrolase activity
BEST7003_RS04075	COG1115	amino acid carrier protein
BEST7003_RS04080	COG0531	amino acid
BEST7003_RS04095	COG0697	spore germination
BEST7003_RS04100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS04100	COG1263	PTS System
BEST7003_RS04105	COG0366	Alpha amylase catalytic
BEST7003_RS04110	COG2188	Transcriptional regulator
BEST7003_RS04115	COG0778	Nitroreductase
BEST7003_RS04120	COG0737	Belongs to the 5'-nucleotidase family
BEST7003_RS04125	COG0693	protein deglycase activity
BEST7003_RS04130	COG2814	Major facilitator Superfamily
BEST7003_RS04135	COG4840	Belongs to the UPF0435 family
BEST7003_RS04140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7003_RS04145	COG4980	gas vesicle protein
BEST7003_RS04150	COG1295	ribonuclease BN
BEST7003_RS04155	COG0477	Major facilitator Superfamily
BEST7003_RS04160	COG0387	Pfam Sodium calcium exchanger
BEST7003_RS04170	COG0668	transmembrane transport
BEST7003_RS04175	COG0535	radical SAM domain protein
BEST7003_RS04185	COG0726	polysaccharide deacetylase
BEST7003_RS04190	COG2084	Dehydrogenase
BEST7003_RS04195	COG0598	Magnesium transport protein CorA
BEST7003_RS04200	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BEST7003_RS04205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BEST7003_RS04215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BEST7003_RS04220	COG4637	Psort location Cytoplasmic, score
BEST7003_RS04230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7003_RS04235	COG0022	dehydrogenase e1 component
BEST7003_RS04240	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7003_RS04245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7003_RS04250	COG3284	Transcriptional regulator
BEST7003_RS04260	COG1742	UPF0060 membrane protein
BEST7003_RS04285	COG4842	Belongs to the WXG100 family
BEST7003_RS04290	COG1486	melibiose metabolic process
BEST7003_RS04295	COG1737	Transcriptional regulator
BEST7003_RS04300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS04300	COG1263	PTS System
BEST7003_RS04305	COG1132	(ABC) transporter
BEST7003_RS04310	COG1132	(ABC) transporter
BEST7003_RS04315	COG2259	Doxx family
BEST7003_RS04320	COG2514	catechol 2,3-dioxygenase activity
BEST7003_RS04325	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_RS04325	COG4977	sequence-specific DNA binding
BEST7003_RS04330	COG2814	Major facilitator Superfamily
BEST7003_RS04335	COG1082	Xylose isomerase domain protein TIM barrel
BEST7003_RS04340	COG0673	inositol 2-dehydrogenase activity
BEST7003_RS04345	COG4585	Histidine kinase
BEST7003_RS04350	COG2197	response regulator
BEST7003_RS04355	COG1131	(ABC) transporter
BEST7003_RS04360	COG0842	Transport permease protein
BEST7003_RS04360	COG1511	domain protein
BEST7003_RS04365	COG0842	Transport permease protein
BEST7003_RS04370	COG1695	Transcriptional regulator
BEST7003_RS04375	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BEST7003_RS04380	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
BEST7003_RS04385	COG1309	transcriptional regulator
BEST7003_RS04390	COG2814	Major facilitator Superfamily
BEST7003_RS04395	COG2318	DinB family
BEST7003_RS04400	COG2814	Major facilitator Superfamily
BEST7003_RS04405	COG1846	Transcriptional regulator
BEST7003_RS04410	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BEST7003_RS04410	COG0392	lysyltransferase activity
BEST7003_RS04415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_RS04420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS04425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS04430	COG0384	phenazine biosynthesis protein PhzF
BEST7003_RS04435	COG0778	Nitroreductase
BEST7003_RS04445	COG1090	epimerase
BEST7003_RS04450	COG2137	regulation of response to DNA damage stimulus
BEST7003_RS04460	COG2814	Major facilitator Superfamily
BEST7003_RS04475	COG3103	Sh3 type 3 domain protein
BEST7003_RS04480	COG5658	integral membrane protein
BEST7003_RS04485	COG0596	Alpha beta hydrolase
BEST7003_RS04490	COG0463	Glycosyl transferase, family 2
BEST7003_RS04495	COG4485	Bacterial membrane protein, YfhO
BEST7003_RS04500	COG1988	membrane-bound metal-dependent
BEST7003_RS04505	COG1194	a g-specific adenine glycosylase
BEST7003_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS04530	COG3557	Belongs to the UPF0374 family
BEST7003_RS04535	COG1132	(ABC) transporter
BEST7003_RS04540	COG4129	membrane
BEST7003_RS04545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BEST7003_RS04550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BEST7003_RS04555	COG0735	belongs to the Fur family
BEST7003_RS04665	COG4326	sporulation control protein
BEST7003_RS04675	COG3340	Belongs to the peptidase S51 family
BEST7003_RS04680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BEST7003_RS04685	COG0277	FAD linked oxidase domain protein
BEST7003_RS04695	COG0753	catalase activity
BEST7003_RS04700	COG1116	anion transmembrane transporter activity
BEST7003_RS04705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7003_RS04710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BEST7003_RS04715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_RS04725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BEST7003_RS04735	COG1476	TRANSCRIPTIONal
BEST7003_RS04745	COG3382	B3 4 domain protein
BEST7003_RS04750	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BEST7003_RS04760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BEST7003_RS04765	COG0789	Transcriptional regulator
BEST7003_RS04770	COG1664	Polymer-forming cytoskeletal
BEST7003_RS04775	COG1664	Polymer-forming cytoskeletal
BEST7003_RS04780	COG2766	serine protein kinase
BEST7003_RS04785	COG2718	Belongs to the UPF0229 family
BEST7003_RS04790	COG1846	Transcriptional regulator
BEST7003_RS04795	COG1566	PFAM secretion protein HlyD family protein
BEST7003_RS04800	COG2814	Major facilitator Superfamily
BEST7003_RS04805	COG0655	NAD(P)H dehydrogenase (quinone) activity
BEST7003_RS04820	COG1725	Transcriptional regulator
BEST7003_RS04825	COG1131	(ABC) transporter
BEST7003_RS04830	COG1131	(ABC) transporter
BEST7003_RS04835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BEST7003_RS04840	COG1278	Cold shock
BEST7003_RS04845	COG1464	Belongs to the NlpA lipoprotein family
BEST7003_RS04850	COG3706	GGDEF domain
BEST7003_RS04855	COG1823	symporter activity
BEST7003_RS04875	COG5577	PFAM Coat F domain
BEST7003_RS04880	COG1525	nuclease
BEST7003_RS04880	COG4085	toxin activity
BEST7003_RS04880	COG0737	Belongs to the 5'-nucleotidase family
BEST7003_RS04885	COG3764	Sortase (surface protein transpeptidase)
BEST7003_RS04890	COG0564	pseudouridine synthase activity
BEST7003_RS04900	COG0517	IMP dehydrogenase activity
BEST7003_RS04905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BEST7003_RS04910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7003_RS04910	COG3153	acetyltransferase
BEST7003_RS04915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BEST7003_RS04920	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BEST7003_RS04925	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BEST7003_RS04930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BEST7003_RS04935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BEST7003_RS04940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BEST7003_RS04945	COG2203	Gaf domain
BEST7003_RS04945	COG4585	Histidine kinase
BEST7003_RS04950	COG2197	response regulator
BEST7003_RS04955	COG0431	NADPH-dependent FMN reductase
BEST7003_RS04970	COG0791	NLP P60 protein
BEST7003_RS04970	COG1388	LysM domain
BEST7003_RS04975	COG1959	2 iron, 2 sulfur cluster binding
BEST7003_RS04980	COG0668	transmembrane transport
BEST7003_RS04985	COG2719	SpoVR family
BEST7003_RS04990	COG1785	Belongs to the alkaline phosphatase family
BEST7003_RS04995	COG0791	NLP P60 protein
BEST7003_RS04995	COG1388	LysM domain
BEST7003_RS05000	COG0583	DNA-binding transcription factor activity
BEST7003_RS05005	COG0372	Belongs to the citrate synthase family
BEST7003_RS05010	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS05015	COG0531	amino acid
BEST7003_RS05020	COG0733	neurotransmitter:sodium symporter activity
BEST7003_RS05025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_RS05030	COG0456	acetyltransferase
BEST7003_RS05045	COG1595	DNA-templated transcription, initiation
BEST7003_RS05050	COG0667	Aldo Keto reductase
BEST7003_RS05055	COG0204	Acyl-transferase
BEST7003_RS05060	COG1253	flavin adenine dinucleotide binding
BEST7003_RS05065	COG0789	Transcriptional regulator
BEST7003_RS05070	COG0436	Aminotransferase
BEST7003_RS05075	COG1253	flavin adenine dinucleotide binding
BEST7003_RS05080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BEST7003_RS05085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BEST7003_RS05090	COG0584	glycerophosphoryl diester phosphodiesterase
BEST7003_RS05095	COG0668	transmembrane transport
BEST7003_RS05100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BEST7003_RS05105	COG0726	polysaccharide deacetylase
BEST7003_RS05110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7003_RS05115	COG1757	Na H antiporter
BEST7003_RS05120	COG0589	response to stress
BEST7003_RS05125	COG1132	(ABC) transporter
BEST7003_RS05130	COG1132	(ABC) transporter
BEST7003_RS05135	COG0702	epimerase
BEST7003_RS05150	COG0189	ligase activity
BEST7003_RS05155	COG0189	ligase activity
BEST7003_RS05160	COG4399	Belongs to the UPF0754 family
BEST7003_RS05165	COG3679	Belongs to the UPF0342 family
BEST7003_RS05170	COG4335	DNA alkylation repair
BEST7003_RS05175	COG0561	phosphatase activity
BEST7003_RS05180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BEST7003_RS05185	COG0475	glutathione-regulated potassium exporter activity
BEST7003_RS05190	COG0490	domain, Protein
BEST7003_RS05200	COG1024	Enoyl-CoA hydratase
BEST7003_RS05210	COG4152	abc transporter atp-binding protein
BEST7003_RS05215	COG1668	transmembrane transport
BEST7003_RS05220	COG0420	3'-5' exonuclease activity
BEST7003_RS05225	COG4717	serine-type aminopeptidase activity
BEST7003_RS05230	COG3481	metal-dependent phosphohydrolase, HD sub domain
BEST7003_RS05240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BEST7003_RS05265	COG1846	Transcriptional regulator
BEST7003_RS05270	COG4980	gas vesicle protein
BEST7003_RS05285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BEST7003_RS05290	COG0537	adenosine 5'-monophosphoramidase activity
BEST7003_RS05295	COG1131	(ABC) transporter
BEST7003_RS05300	COG4473	ABC transporter
BEST7003_RS05310	COG1473	amidohydrolase
BEST7003_RS05315	COG3069	C4-dicarboxylate transmembrane transporter activity
BEST7003_RS05325	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_RS05330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7003_RS05335	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BEST7003_RS05340	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BEST7003_RS05345	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BEST7003_RS05350	COG1309	transcriptional regulator
BEST7003_RS05355	COG1511	domain protein
BEST7003_RS05360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7003_RS05365	COG4377	Putative membrane peptidase family (DUF2324)
BEST7003_RS05375	COG1363	Peptidase, m42
BEST7003_RS05380	COG4405	Protein conserved in bacteria
BEST7003_RS05385	COG1301	dicarboxylic acid transport
BEST7003_RS05390	COG1234	tRNA 3'-trailer cleavage
BEST7003_RS05395	COG0095	Lipoate-protein ligase
BEST7003_RS05400	COG0702	epimerase
BEST7003_RS05405	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_RS05415	COG0501	Belongs to the peptidase M48B family
BEST7003_RS05420	COG1404	Belongs to the peptidase S8 family
BEST7003_RS05425	COG0456	acetyltransferase
BEST7003_RS05430	COG0604	alcohol dehydrogenase
BEST7003_RS05435	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BEST7003_RS05440	COG0406	alpha-ribazole phosphatase activity
BEST7003_RS05445	COG0183	Belongs to the thiolase family
BEST7003_RS05450	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_RS05455	COG1268	BioY protein
BEST7003_RS05460	COG0840	transmembrane signaling receptor activity
BEST7003_RS05465	COG0723	plastoquinol--plastocyanin reductase activity
BEST7003_RS05465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7003_RS05470	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS05480	COG4903	ComK protein
BEST7003_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS05495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_RS05510	COG0398	Pfam SNARE associated Golgi protein
BEST7003_RS05515	COG0681	Belongs to the peptidase S26 family
BEST7003_RS05520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BEST7003_RS05525	COG1846	Transcriptional regulator
BEST7003_RS05530	COG0738	Major facilitator superfamily
BEST7003_RS05535	COG0673	inositol 2-dehydrogenase activity
BEST7003_RS05540	COG0561	phosphatase activity
BEST7003_RS05545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7003_RS05550	COG1609	Transcriptional regulator
BEST7003_RS05555	COG3180	Ammonia monooxygenase
BEST7003_RS05560	COG2814	Major facilitator Superfamily
BEST7003_RS05560	COG0477	Major facilitator Superfamily
BEST7003_RS05565	COG4533	DNA binding
BEST7003_RS05575	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BEST7003_RS05580	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BEST7003_RS05585	COG1074	ATP-dependent DNA helicase activity
BEST7003_RS05590	COG0420	3'-5' exonuclease activity
BEST7003_RS05595	COG0419	ATPase involved in DNA repair
BEST7003_RS05600	COG1403	HNH endonuclease
BEST7003_RS05640	COG5337	Spore coat protein CotH
BEST7003_RS05645	COG0179	Fumarylacetoacetate (FAA) hydrolase
BEST7003_RS05655	COG1404	Belongs to the peptidase S8 family
BEST7003_RS05665	COG0367	asparagine synthase
BEST7003_RS05670	COG2318	DinB family
BEST7003_RS05675	COG1562	ergosterol biosynthetic process
BEST7003_RS05680	COG0534	Mate efflux family protein
BEST7003_RS05685	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_RS05685	COG2207	Transcriptional regulator
BEST7003_RS05690	COG1609	Transcriptional regulator
BEST7003_RS05695	COG0673	inositol 2-dehydrogenase activity
BEST7003_RS05700	COG2318	DinB family
BEST7003_RS05705	COG1279	arginine transmembrane transporter activity
BEST7003_RS05710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_RS05715	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7003_RS05720	COG2267	carboxylic ester hydrolase activity
BEST7003_RS05725	COG0529	Catalyzes the synthesis of activated sulfate
BEST7003_RS05730	COG2046	Belongs to the sulfate adenylyltransferase family
BEST7003_RS05735	COG0175	sulfate reduction
BEST7003_RS05740	COG2045	Belongs to the ComB family
BEST7003_RS05745	COG1809	phosphosulfolactate synthase activity
BEST7003_RS05750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_RS05755	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7003_RS05760	COG2814	Major facilitator Superfamily
BEST7003_RS05765	COG0454	-acetyltransferase
BEST7003_RS05770	COG2153	protein acetylation
BEST7003_RS05775	COG0646	methionine synthase
BEST7003_RS05775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BEST7003_RS05780	COG1666	GTP binding
BEST7003_RS05785	COG2996	Protein conserved in bacteria
BEST7003_RS05805	COG1695	Transcriptional regulator
BEST7003_RS05820	COG3227	Zinc metalloprotease (Elastase)
BEST7003_RS05825	COG1307	EDD domain protein, DegV family
BEST7003_RS05830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_RS05845	COG0561	phosphatase activity
BEST7003_RS05850	COG1073	alpha beta
BEST7003_RS05855	COG2151	metal-sulfur cluster biosynthetic enzyme
BEST7003_RS05860	COG0277	FAD linked oxidase domain protein
BEST7003_RS05865	COG2271	Major facilitator Superfamily
BEST7003_RS05870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BEST7003_RS05875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BEST7003_RS05885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BEST7003_RS05890	COG0505	Belongs to the CarA family
BEST7003_RS05895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7003_RS05900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BEST7003_RS05915	COG2267	carboxylic ester hydrolase activity
BEST7003_RS05925	COG1744	ABC transporter substrate-binding protein PnrA-like
BEST7003_RS05940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7003_RS05945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BEST7003_RS05950	COG5504	Zn-dependent protease
BEST7003_RS05955	COG0444	Belongs to the ABC transporter superfamily
BEST7003_RS05960	COG4608	Belongs to the ABC transporter superfamily
BEST7003_RS05970	COG0601	transmembrane transport
BEST7003_RS05975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7003_RS05985	COG0180	Tryptophanyl-tRNA synthetase
BEST7003_RS05990	COG4166	transmembrane transport
BEST7003_RS05995	COG0601	transmembrane transport
BEST7003_RS06000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7003_RS06005	COG0444	Belongs to the ABC transporter superfamily
BEST7003_RS06010	COG4608	Belongs to the ABC transporter superfamily
BEST7003_RS06015	COG2814	Major facilitator Superfamily
BEST7003_RS06020	COG0456	acetyltransferase
BEST7003_RS06025	COG1393	Belongs to the ArsC family
BEST7003_RS06030	COG0861	Integral membrane protein TerC family
BEST7003_RS06035	COG4862	establishment of competence for transformation
BEST7003_RS06040	COG4469	Competence protein
BEST7003_RS06045	COG1164	Oligoendopeptidase f
BEST7003_RS06055	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BEST7003_RS06060	COG2346	COG2346, Truncated hemoglobins
BEST7003_RS06065	COG0741	lytic transglycosylase activity
BEST7003_RS06070	COG4116	CYTH
BEST7003_RS06080	COG2357	RelA SpoT domain protein
BEST7003_RS06085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BEST7003_RS06090	COG0564	pseudouridine synthase activity
BEST7003_RS06095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BEST7003_RS06100	COG0569	domain protein
BEST7003_RS06100	COG0475	glutathione-regulated potassium exporter activity
BEST7003_RS06105	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BEST7003_RS06110	COG0352	thiamine-phosphate diphosphorylase activity
BEST7003_RS06115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7003_RS06120	COG2104	thiamine diphosphate biosynthetic process
BEST7003_RS06125	COG2022	thiamine diphosphate biosynthetic process
BEST7003_RS06130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BEST7003_RS06135	COG0351	phosphomethylpyrimidine kinase
BEST7003_RS06140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BEST7003_RS06195	COG0210	DNA helicase
BEST7003_RS06205	COG2153	protein acetylation
BEST7003_RS06210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BEST7003_RS06215	COG2382	esterase
BEST7003_RS06220	COG0626	cystathionine gamma-synthase activity
BEST7003_RS06225	COG0626	cystathionine gamma-synthase activity
BEST7003_RS06230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_RS06235	COG5505	Protein of unknown function (DUF819)
BEST7003_RS06255	COG3677	Transposase
BEST7003_RS06270	COG5484	DNA packaging
BEST7003_RS06275	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BEST7003_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS06290	COG3711	transcriptional antiterminator
BEST7003_RS06290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_RS06295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7003_RS06295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7003_RS06295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_RS06300	COG1482	cell wall glycoprotein biosynthetic process
BEST7003_RS06310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_RS06320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BEST7003_RS06335	COG0109	protoheme IX farnesyltransferase activity
BEST7003_RS06345	COG0726	polysaccharide deacetylase
BEST7003_RS06355	COG5504	Zn-dependent protease
BEST7003_RS06360	COG2205	protein histidine kinase activity
BEST7003_RS06370	COG3383	formate dehydrogenase (NAD+) activity
BEST7003_RS06375	COG2427	Protein of unknown function (DUF1641)
BEST7003_RS06385	COG1051	belongs to the nudix hydrolase family
BEST7003_RS06395	COG2124	cytochrome p450
BEST7003_RS06400	COG1819	glycosyl
BEST7003_RS06410	COG1587	Uroporphyrinogen-III synthase
BEST7003_RS06415	COG0390	transport system, permease component
BEST7003_RS06420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7003_RS06425	COG0697	spore germination
BEST7003_RS06430	COG4297	protein containing double-stranded beta helix domain
BEST7003_RS06440	COG1252	NADH dehydrogenase
BEST7003_RS06445	COG1904	glucuronate isomerase
BEST7003_RS06450	COG2211	Major facilitator Superfamily
BEST7003_RS06455	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BEST7003_RS06460	COG1063	alcohol dehydrogenase
BEST7003_RS06465	COG1312	Catalyzes the dehydration of D-mannonate
BEST7003_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS06475	COG2271	Major facilitator Superfamily
BEST7003_RS06480	COG1609	Transcriptional regulator
BEST7003_RS06485	COG0246	Mannitol dehydrogenase
BEST7003_RS06490	COG2721	sulfolactate sulfo-lyase activity
BEST7003_RS06495	COG0730	response to heat
BEST7003_RS06500	COG2318	DinB family
BEST7003_RS06505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7003_RS06510	COG0457	Tetratricopeptide repeat
BEST7003_RS06520	COG2350	Protein conserved in bacteria
BEST7003_RS06525	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS06525	COG1388	LysM domain
BEST7003_RS06525	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS06535	COG4195	phage-related replication protein
BEST7003_RS06540	COG3546	catalase activity
BEST7003_RS06545	COG2856	Zn peptidase
BEST7003_RS06550	COG1396	sequence-specific DNA binding
BEST7003_RS06560	COG1522	sequence-specific DNA binding
BEST7003_RS06565	COG1484	DNA-dependent DNA replication
BEST7003_RS06580	COG1595	DNA-templated transcription, initiation
BEST7003_RS06585	COG5484	DNA packaging
BEST7003_RS06585	COG3728	DNA packaging
BEST7003_RS06590	COG1783	phage Terminase large subunit
BEST7003_RS06595	COG5518	Phage portal protein
BEST7003_RS06600	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BEST7003_RS06605	COG4653	Phage capsid family
BEST7003_RS06650	COG5412	phage tail tape measure protein
BEST7003_RS06650	COG3953	SLT domain
BEST7003_RS06655	COG1652	LysM domain
BEST7003_RS06660	COG4193	domain, Protein
BEST7003_RS06670	COG3628	GPW Gp25 family protein
BEST7003_RS06675	COG3299	homolog of phage Mu protein gp47
BEST7003_RS06680	COG3778	Protein conserved in bacteria
BEST7003_RS06720	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS06720	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS06735	COG0306	phosphate transporter
BEST7003_RS06740	COG1392	Phosphate transport regulator
BEST7003_RS06745	COG0531	amino acid
BEST7003_RS06750	COG0346	lactoylglutathione lyase activity
BEST7003_RS06755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BEST7003_RS06760	COG0463	Glycosyl transferase, family 2
BEST7003_RS06765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7003_RS06770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7003_RS06775	COG2362	D-Aminopeptidase
BEST7003_RS06780	COG0601	transmembrane transport
BEST7003_RS06785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7003_RS06790	COG0444	Belongs to the ABC transporter superfamily
BEST7003_RS06795	COG4166	transmembrane transport
BEST7003_RS06800	COG1619	proteins homologs of microcin C7 resistance protein MccF
BEST7003_RS06805	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7003_RS06810	COG0791	NLP P60 protein
BEST7003_RS06815	COG4608	Belongs to the ABC transporter superfamily
BEST7003_RS06820	COG2706	6-phosphogluconolactonase activity
BEST7003_RS06825	COG1834	amidinotransferase
BEST7003_RS06830	COG1607	acyl-coa hydrolase
BEST7003_RS06835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BEST7003_RS06835	COG1017	nitric oxide dioxygenase activity
BEST7003_RS06845	COG2323	membrane
BEST7003_RS06850	COG2318	DinB family
BEST7003_RS06855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_RS06860	COG2076	Multidrug Resistance protein
BEST7003_RS06865	COG2076	Multidrug Resistance protein
BEST7003_RS06870	COG0788	formyltetrahydrofolate deformylase activity
BEST7003_RS06875	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7003_RS06905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7003_RS06910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BEST7003_RS06915	COG1764	response to oxidative stress
BEST7003_RS06920	COG1846	Transcriptional regulator
BEST7003_RS06925	COG1764	response to oxidative stress
BEST7003_RS06930	COG0590	tRNA wobble adenosine to inosine editing
BEST7003_RS06935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BEST7003_RS06940	COG1404	Belongs to the peptidase S8 family
BEST7003_RS06945	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_RS06950	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BEST7003_RS06955	COG1122	ATPase activity
BEST7003_RS06960	COG4721	ABC-type cobalt transport system, permease component
BEST7003_RS06970	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS06975	COG3850	Histidine kinase
BEST7003_RS06975	COG5002	protein histidine kinase activity
BEST7003_RS06980	COG3212	peptidase
BEST7003_RS06985	COG3212	peptidase
BEST7003_RS06995	COG2239	Acts as a magnesium transporter
BEST7003_RS07000	COG0789	Transcriptional regulator
BEST7003_RS07010	COG1846	Transcriptional regulator
BEST7003_RS07015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7003_RS07020	COG0726	polysaccharide deacetylase
BEST7003_RS07025	COG1408	metallophosphoesterase
BEST7003_RS07035	COG0463	Glycosyl transferase, family 2
BEST7003_RS07040	COG1793	dna ligase
BEST7003_RS07040	COG3285	dna ligase
BEST7003_RS07045	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BEST7003_RS07050	COG5001	Diguanylate cyclase
BEST7003_RS07050	COG3300	MHYT domain
BEST7003_RS07055	COG0586	Pfam SNARE associated Golgi protein
BEST7003_RS07060	COG0861	Integral membrane protein TerC family
BEST7003_RS07065	COG1191	sigma factor activity
BEST7003_RS07085	COG0501	Belongs to the peptidase M48B family
BEST7003_RS07090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BEST7003_RS07095	COG3594	Acyltransferase
BEST7003_RS07100	COG5002	protein histidine kinase activity
BEST7003_RS07105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BEST7003_RS07110	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BEST7003_RS07115	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BEST7003_RS07120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7003_RS07125	COG0436	Aminotransferase
BEST7003_RS07130	COG1850	ribulose-bisphosphate carboxylase activity
BEST7003_RS07135	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BEST7003_RS07140	COG0235	Class ii aldolase
BEST7003_RS07145	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BEST7003_RS07150	COG3339	Conserved Protein
BEST7003_RS07165	COG3852	Histidine kinase
BEST7003_RS07170	COG1846	Transcriptional regulator
BEST7003_RS07175	COG1360	Flagellar Motor Protein
BEST7003_RS07180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BEST7003_RS07185	COG0542	response to heat
BEST7003_RS07190	COG3949	Membrane
BEST7003_RS07195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BEST7003_RS07200	COG0720	synthase
BEST7003_RS07205	COG0602	queuosine metabolic process
BEST7003_RS07210	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BEST7003_RS07215	COG1733	regulation of RNA biosynthetic process
BEST7003_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS07225	COG1388	LysM domain
BEST7003_RS07225	COG4641	Protein conserved in bacteria
BEST7003_RS07230	COG1388	LysM domain
BEST7003_RS07235	COG3858	chitin binding
BEST7003_RS07240	COG3858	chitin binding
BEST7003_RS07250	COG4873	Protein conserved in bacteria
BEST7003_RS07260	COG3773	Cell wall hydrolase
BEST7003_RS07265	COG2244	polysaccharide biosynthetic process
BEST7003_RS07270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS07275	COG2217	Heavy metal translocating P-type atpase
BEST7003_RS07285	COG0006	proline dipeptidase activity
BEST7003_RS07290	COG1609	Transcriptional regulator
BEST7003_RS07295	COG3711	transcriptional antiterminator
BEST7003_RS07300	COG2190	(PTS) system
BEST7003_RS07300	COG1263	PTS System
BEST7003_RS07300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS07305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_RS07310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BEST7003_RS07320	COG1533	DNA photolyase activity
BEST7003_RS07325	COG0456	acetyltransferase
BEST7003_RS07330	COG0840	transmembrane signaling receptor activity
BEST7003_RS07335	COG2084	Dehydrogenase
BEST7003_RS07340	COG2340	Cysteine-rich secretory protein family
BEST7003_RS07345	COG0768	penicillin binding
BEST7003_RS07350	COG4191	Histidine kinase
BEST7003_RS07355	COG0436	Aminotransferase
BEST7003_RS07360	COG0784	Response regulator, receiver
BEST7003_RS07360	COG0835	chemotaxis
BEST7003_RS07370	COG2814	Major facilitator Superfamily
BEST7003_RS07375	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7003_RS07380	COG1408	metallophosphoesterase
BEST7003_RS07385	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS07390	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS07395	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS07405	COG2200	EAL domain
BEST7003_RS07410	COG4703	Protein of unknown function (DUF1797)
BEST7003_RS07415	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BEST7003_RS07425	COG0517	IMP dehydrogenase activity
BEST7003_RS07430	COG0583	DNA-binding transcription factor activity
BEST7003_RS07435	COG0716	FMN binding
BEST7003_RS07445	COG0716	FMN binding
BEST7003_RS07450	COG2171	N-acyltransferase activity
BEST7003_RS07455	COG1473	amidohydrolase
BEST7003_RS07465	COG0668	transmembrane transport
BEST7003_RS07470	COG0450	alkyl hydroperoxide reductase
BEST7003_RS07475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS07490	COG0746	molybdenum cofactor guanylyltransferase activity
BEST7003_RS07495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BEST7003_RS07500	COG0303	'Molybdopterin
BEST7003_RS07505	COG1763	Mo-molybdopterin cofactor biosynthetic process
BEST7003_RS07510	COG0314	molybdopterin synthase activity
BEST7003_RS07515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BEST7003_RS07520	COG1132	(ABC) transporter
BEST7003_RS07525	COG1132	(ABC) transporter
BEST7003_RS07535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BEST7003_RS07540	COG1136	(ABC) transporter
BEST7003_RS07545	COG0577	efflux transmembrane transporter activity
BEST7003_RS07550	COG1349	DNA-binding transcription factor activity
BEST7003_RS07555	COG1105	Belongs to the carbohydrate kinase PfkB family
BEST7003_RS07560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7003_RS07560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7003_RS07560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_RS07565	COG0681	Belongs to the peptidase S26 family
BEST7003_RS07575	COG0488	(ABC) transporter
BEST7003_RS07580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BEST7003_RS07585	COG2309	aminopeptidase activity
BEST7003_RS07590	COG1077	Cell shape determining protein MreB Mrl
BEST7003_RS07595	COG2002	toxin-antitoxin pair type II binding
BEST7003_RS07600	COG3852	Histidine kinase
BEST7003_RS07605	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BEST7003_RS07605	COG2105	PFAM AIG2 family protein
BEST7003_RS07610	COG0569	domain protein
BEST7003_RS07615	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BEST7003_RS07620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BEST7003_RS07625	COG5503	Protein of unknown function (DUF1447)
BEST7003_RS07630	COG0561	phosphatase activity
BEST7003_RS07635	COG0242	peptide deformylase activity
BEST7003_RS07645	COG0497	DNA recombination
BEST7003_RS07650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7003_RS07655	COG0022	dehydrogenase e1 component
BEST7003_RS07660	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7003_RS07665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7003_RS07670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS07675	COG1982	Orn Lys Arg decarboxylase major
BEST7003_RS07680	COG4476	Belongs to the UPF0223 family
BEST7003_RS07685	COG4493	Belongs to the UPF0637 family
BEST7003_RS07695	COG0483	inositol monophosphate 1-phosphatase activity
BEST7003_RS07705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BEST7003_RS07725	COG1595	DNA-templated transcription, initiation
BEST7003_RS07745	COG1217	gtp-binding protein TYPA
BEST7003_RS07755	COG4896	Protein conserved in bacteria
BEST7003_RS07765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BEST7003_RS07770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BEST7003_RS07775	COG2066	Belongs to the glutaminase family
BEST7003_RS07780	COG4838	Belongs to the UPF0358 family
BEST7003_RS07785	COG0772	Belongs to the SEDS family
BEST7003_RS07790	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BEST7003_RS07795	COG1612	heme a metabolic process
BEST7003_RS07800	COG0109	protoheme IX farnesyltransferase activity
BEST7003_RS07805	COG2010	Cytochrome c
BEST7003_RS07805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BEST7003_RS07810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BEST7003_RS07815	COG1845	cytochrome c oxidase, subunit III
BEST7003_RS07820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BEST7003_RS07825	COG3336	cytochrome c oxidase
BEST7003_RS07835	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BEST7003_RS07840	COG2340	Cysteine-rich secretory protein family
BEST7003_RS07855	COG3679	Belongs to the UPF0342 family
BEST7003_RS07860	COG4471	UPF0298 protein
BEST7003_RS07865	COG0742	ribosomal rna small subunit methyltransferase
BEST7003_RS07870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BEST7003_RS07875	COG3314	Sporulation integral membrane protein YlbJ
BEST7003_RS07880	COG1752	Esterase of the alpha-beta hydrolase superfamily
BEST7003_RS07885	COG3480	Lon protease (S16) C-terminal proteolytic domain
BEST7003_RS07890	COG1323	Belongs to the UPF0348 family
BEST7003_RS07900	COG1399	metal-binding, possibly nucleic acid-binding protein
BEST7003_RS07910	COG0454	-acetyltransferase
BEST7003_RS07915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BEST7003_RS07920	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BEST7003_RS07925	COG2001	Belongs to the MraZ family
BEST7003_RS07930	COG0275	rRNA processing
BEST7003_RS07935	COG4839	cell division protein FtsL
BEST7003_RS07940	COG0768	penicillin binding
BEST7003_RS07945	COG0768	penicillin binding
BEST7003_RS07950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BEST7003_RS07955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BEST7003_RS07960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BEST7003_RS07965	COG0772	Belongs to the SEDS family
BEST7003_RS07970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7003_RS07975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BEST7003_RS07980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BEST7003_RS07985	COG3879	Bacterial protein of unknown function (DUF881)
BEST7003_RS07990	COG3879	Bacterial protein of unknown function (DUF881)
BEST7003_RS07995	COG3856	small basic protein
BEST7003_RS08000	COG0849	cell division
BEST7003_RS08005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BEST7003_RS08010	COG4412	M6 family metalloprotease domain protein
BEST7003_RS08010	COG1404	Belongs to the peptidase S8 family
BEST7003_RS08020	COG1191	sigma factor activity
BEST7003_RS08025	COG1191	sigma factor activity
BEST7003_RS08030	COG1119	ATPase activity
BEST7003_RS08035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7003_RS08040	COG1873	PFAM PRC-barrel domain
BEST7003_RS08045	COG1496	oxidoreductase activity
BEST7003_RS08050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BEST7003_RS08055	COG1799	cell septum assembly
BEST7003_RS08060	COG0762	integral membrane protein
BEST7003_RS08065	COG2302	S4 RNA-binding domain
BEST7003_RS08070	COG3599	regulation of cell shape
BEST7003_RS08075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BEST7003_RS08080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BEST7003_RS08085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BEST7003_RS08090	COG0564	pseudouridine synthase activity
BEST7003_RS08095	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BEST7003_RS08100	COG2233	PERMEase
BEST7003_RS08105	COG0540	Belongs to the ATCase OTCase family
BEST7003_RS08110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BEST7003_RS08115	COG0505	Belongs to the CarA family
BEST7003_RS08120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7003_RS08125	COG0543	2 iron, 2 sulfur cluster binding
BEST7003_RS08130	COG0167	dihydroorotate dehydrogenase activity
BEST7003_RS08135	COG0284	orotidine-5'-phosphate decarboxylase activity
BEST7003_RS08140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BEST7003_RS08145	COG0175	sulfate reduction
BEST7003_RS08150	COG0306	phosphate transporter
BEST7003_RS08155	COG2046	Belongs to the sulfate adenylyltransferase family
BEST7003_RS08160	COG0529	Catalyzes the synthesis of activated sulfate
BEST7003_RS08165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BEST7003_RS08170	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BEST7003_RS08175	COG1648	precorrin-2 dehydrogenase activity
BEST7003_RS08180	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BEST7003_RS08185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7003_RS08190	COG1561	YicC-like family, N-terminal region
BEST7003_RS08200	COG0194	GDP metabolic process
BEST7003_RS08205	COG1758	RNA polymerase activity
BEST7003_RS08210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BEST7003_RS08215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BEST7003_RS08220	COG0242	peptide deformylase activity
BEST7003_RS08225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BEST7003_RS08230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BEST7003_RS08230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BEST7003_RS08235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BEST7003_RS08240	COG0631	protein serine/threonine phosphatase activity
BEST7003_RS08245	COG0515	serine threonine protein kinase
BEST7003_RS08245	COG2815	serine threonine protein kinase
BEST7003_RS08250	COG1162	GTPase activity
BEST7003_RS08255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BEST7003_RS08260	COG1564	THIamine pyrophosphokinase
BEST7003_RS08270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BEST7003_RS08275	COG1302	Protein conserved in bacteria
BEST7003_RS08280	COG1461	Dihydroxyacetone kinase
BEST7003_RS08285	COG1760	l-serine dehydratase
BEST7003_RS08290	COG1760	l-serine dehydratase
BEST7003_RS08295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BEST7003_RS08300	COG1349	DNA-binding transcription factor activity
BEST7003_RS08300	COG2050	protein possibly involved in aromatic compounds catabolism
BEST7003_RS08305	COG0416	fatty acid biosynthetic process
BEST7003_RS08310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7003_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS08325	COG0571	ribonuclease III activity
BEST7003_RS08330	COG1196	nuclear chromosome segregation
BEST7003_RS08335	COG0552	protein localization to endoplasmic reticulum
BEST7003_RS08345	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BEST7003_RS08350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BEST7003_RS08355	COG0228	four-way junction DNA binding
BEST7003_RS08360	COG1837	Belongs to the UPF0109 family
BEST7003_RS08370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BEST7003_RS08375	COG0336	Belongs to the RNA methyltransferase TrmD family
BEST7003_RS08380	COG0335	large ribosomal subunit rRNA binding
BEST7003_RS08385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BEST7003_RS08390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BEST7003_RS08400	COG2257	FlhB HrpN YscU SpaS Family
BEST7003_RS08405	COG0045	succinate-CoA ligase (ADP-forming) activity
BEST7003_RS08410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BEST7003_RS08415	COG0758	DNA mediated transformation
BEST7003_RS08420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BEST7003_RS08425	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BEST7003_RS08430	COG4974	Belongs to the 'phage' integrase family
BEST7003_RS08435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BEST7003_RS08440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BEST7003_RS08445	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BEST7003_RS08450	COG1815	bacterial-type flagellum-dependent cell motility
BEST7003_RS08455	COG1558	bacterial-type flagellum-dependent cell motility
BEST7003_RS08460	COG1677	Flagellar hook-basal body complex protein FliE
BEST7003_RS08465	COG1766	The M ring may be actively involved in energy transduction
BEST7003_RS08470	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BEST7003_RS08475	COG1317	bacterial-type flagellum organization
BEST7003_RS08480	COG1157	protein secretion by the type III secretion system
BEST7003_RS08485	COG2882	bacterial-type flagellum organization
BEST7003_RS08490	COG3334	PFAM MgtE intracellular
BEST7003_RS08495	COG3144	bacterial-type flagellum assembly
BEST7003_RS08500	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BEST7003_RS08505	COG4786	Flagellar basal body rod
BEST7003_RS08510	COG1582	Flagellar protein (FlbD)
BEST7003_RS08515	COG1580	Controls the rotational direction of flagella during chemotaxis
BEST7003_RS08520	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BEST7003_RS08525	COG1776	CheC inhibitor of MCP methylation
BEST7003_RS08525	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BEST7003_RS08530	COG2201	protein-glutamate methylesterase activity
BEST7003_RS08535	COG3190	flagellar
BEST7003_RS08540	COG1338	Plays a role in the flagellum-specific transport system
BEST7003_RS08545	COG1987	bacterial-type flagellum assembly
BEST7003_RS08550	COG1684	flagellar biosynthetic protein fliR
BEST7003_RS08555	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BEST7003_RS08560	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BEST7003_RS08565	COG1419	protein localization to endoplasmic reticulum
BEST7003_RS08570	COG0455	bacterial-type flagellum organization
BEST7003_RS08575	COG2201	protein-glutamate methylesterase activity
BEST7003_RS08580	COG0643	Histidine kinase
BEST7003_RS08580	COG2198	Histidine kinase
BEST7003_RS08585	COG0835	chemotaxis
BEST7003_RS08590	COG1776	CheC inhibitor of MCP methylation
BEST7003_RS08595	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BEST7003_RS08600	COG1191	sigma factor activity
BEST7003_RS08610	COG0052	Belongs to the universal ribosomal protein uS2 family
BEST7003_RS08615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BEST7003_RS08620	COG0528	UMP kinase activity
BEST7003_RS08625	COG0233	cytoplasmic translational termination
BEST7003_RS08630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BEST7003_RS08635	COG4589	Belongs to the CDS family
BEST7003_RS08640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BEST7003_RS08645	COG0750	zinc metalloprotease
BEST7003_RS08650	COG0442	prolyl-tRNA aminoacylation
BEST7003_RS08655	COG2176	DNA-directed DNA polymerase activity
BEST7003_RS08660	COG0779	Required for maturation of 30S ribosomal subunits
BEST7003_RS08665	COG0195	Participates in both transcription termination and antitermination
BEST7003_RS08670	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BEST7003_RS08675	COG1358	cellular component organization or biogenesis
BEST7003_RS08680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BEST7003_RS08685	COG1550	Protein conserved in bacteria
BEST7003_RS08690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BEST7003_RS08695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BEST7003_RS08700	COG0196	riboflavin kinase activity
BEST7003_RS08705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BEST7003_RS08710	COG1185	polyribonucleotide nucleotidyltransferase activity
BEST7003_RS08715	COG0726	polysaccharide deacetylase
BEST7003_RS08720	COG0612	Peptidase, M16
BEST7003_RS08725	COG1873	PFAM PRC-barrel domain
BEST7003_RS08730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BEST7003_RS08735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BEST7003_RS08740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BEST7003_RS08745	COG0527	aspartate kinase activity
BEST7003_RS08750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BEST7003_RS08755	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BEST7003_RS08760	COG0740	serine-type endopeptidase activity
BEST7003_RS08770	COG4980	gas vesicle protein
BEST7003_RS08770	COG1674	ftsk spoiiie
BEST7003_RS08775	COG2188	Transcriptional regulator
BEST7003_RS08780	COG2814	Major facilitator Superfamily
BEST7003_RS08785	COG0612	Peptidase, M16
BEST7003_RS08790	COG0612	Peptidase, M16
BEST7003_RS08795	COG0300	oxidoreductase activity
BEST7003_RS08810	COG1426	Protein conserved in bacteria
BEST7003_RS08815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BEST7003_RS08820	COG1058	Belongs to the CinA family
BEST7003_RS08820	COG1546	Belongs to the CinA family
BEST7003_RS08825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BEST7003_RS08830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BEST7003_RS08835	COG1418	mRNA catabolic process
BEST7003_RS08840	COG1692	metallophosphoesterase
BEST7003_RS08845	COG2359	stage V sporulation protein S
BEST7003_RS08850	COG1063	alcohol dehydrogenase
BEST7003_RS08855	COG0156	8-amino-7-oxononanoate synthase activity
BEST7003_RS08860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7003_RS08865	COG4550	Control of competence regulator ComK, YlbF/YmcA
BEST7003_RS08875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BEST7003_RS08880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BEST7003_RS08895	COG3226	Transcriptional regulator
BEST7003_RS08900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_RS08910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7003_RS08915	COG3321	synthase
BEST7003_RS08920	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7003_RS08920	COG2070	2-Nitropropane dioxygenase
BEST7003_RS08925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_RS08930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BEST7003_RS08935	COG3425	synthase
BEST7003_RS08940	COG1024	Enoyl-CoA hydratase
BEST7003_RS08945	COG1024	Enoyl-CoA hydratase
BEST7003_RS08950	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_RS08950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_RS08950	COG3321	synthase
BEST7003_RS08950	COG0300	oxidoreductase activity
BEST7003_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS08955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_RS08955	COG0300	oxidoreductase activity
BEST7003_RS08955	COG4221	oxidoreductase activity
BEST7003_RS08955	COG3321	synthase
BEST7003_RS08960	COG3321	synthase
BEST7003_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS08960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_RS08960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7003_RS08960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_RS08970	COG3321	synthase
BEST7003_RS08970	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BEST7003_RS08970	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BEST7003_RS08970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_RS08975	COG2124	cytochrome p450
BEST7003_RS08985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_RS08990	COG1404	Belongs to the peptidase S8 family
BEST7003_RS08995	COG4195	phage-related replication protein
BEST7003_RS09000	COG1764	response to oxidative stress
BEST7003_RS09005	COG2076	Multidrug Resistance protein
BEST7003_RS09010	COG2076	Multidrug Resistance protein
BEST7003_RS09025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BEST7003_RS09030	COG1923	regulation of RNA biosynthetic process
BEST7003_RS09045	COG1780	Probably involved in ribonucleotide reductase function
BEST7003_RS09050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BEST7003_RS09055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BEST7003_RS09060	COG4112	unkown
BEST7003_RS09065	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS09070	COG0464	growth
BEST7003_RS09075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BEST7003_RS09080	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BEST7003_RS09085	COG0789	Transcriptional regulator
BEST7003_RS09090	COG0174	glutamine synthetase
BEST7003_RS09110	COG4282	regulation of fungal-type cell wall biogenesis
BEST7003_RS09120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_RS09145	COG0135	phosphoribosylanthranilate isomerase activity
BEST7003_RS09150	COG2211	Major facilitator Superfamily
BEST7003_RS09155	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7003_RS09160	COG1940	carbohydrate kinase activity
BEST7003_RS09165	COG2115	Belongs to the xylose isomerase family
BEST7003_RS09170	COG1070	Carbohydrate kinase
BEST7003_RS09175	COG1525	nuclease
BEST7003_RS09180	COG2814	Major facilitator Superfamily
BEST7003_RS09185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BEST7003_RS09195	COG0756	dUTP diphosphatase activity
BEST7003_RS09205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BEST7003_RS09230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7003_RS09240	COG3832	glyoxalase III activity
BEST7003_RS09250	COG0697	spore germination
BEST7003_RS09255	COG0531	amino acid
BEST7003_RS09285	COG4195	phage-related replication protein
BEST7003_RS09295	COG0346	lactoylglutathione lyase activity
BEST7003_RS09300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BEST7003_RS09305	COG1388	LysM domain
BEST7003_RS09310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7003_RS09315	COG4224	UPF0291 protein
BEST7003_RS09320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BEST7003_RS09330	COG3763	UPF0154 protein
BEST7003_RS09340	COG0785	Cytochrome C biogenesis protein
BEST7003_RS09345	COG2201	protein-glutamate methylesterase activity
BEST7003_RS09350	COG4846	Membrane protein involved in cytochrome C biogenesis
BEST7003_RS09360	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7003_RS09375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BEST7003_RS09380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS09395	COG0824	Thioesterase
BEST7003_RS09405	COG4841	protein insertion into membrane
BEST7003_RS09410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BEST7003_RS09415	COG1832	CoA-binding protein
BEST7003_RS09420	COG0187	DNA topoisomerase II activity
BEST7003_RS09425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BEST7003_RS09435	COG1115	amino acid carrier protein
BEST7003_RS09450	COG5520	Belongs to the glycosyl hydrolase 30 family
BEST7003_RS09455	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7003_RS09460	COG2246	polysaccharide biosynthetic process
BEST7003_RS09465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7003_RS09470	COG0586	Pfam SNARE associated Golgi protein
BEST7003_RS09475	COG2404	hydrolase activity, acting on ester bonds
BEST7003_RS09480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BEST7003_RS09485	COG1024	Enoyl-CoA hydratase
BEST7003_RS09490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BEST7003_RS09495	COG0511	ligase activity, forming carbon-carbon bonds
BEST7003_RS09500	COG0439	Biotin carboxylase
BEST7003_RS09505	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_RS09510	COG1960	acyl-CoA dehydrogenase activity
BEST7003_RS09520	COG1649	PFAM Uncharacterised BCR, COG1649
BEST7003_RS09530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_RS09530	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BEST7003_RS09535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_RS09545	COG2027	D-alanyl-D-alanine carboxypeptidase
BEST7003_RS09550	COG2017	converts alpha-aldose to the beta-anomer
BEST7003_RS09555	COG0534	Mate efflux family protein
BEST7003_RS09570	COG0582	viral genome integration into host DNA
BEST7003_RS09575	COG0166	Belongs to the GPI family
BEST7003_RS09580	COG0405	Gamma-glutamyltransferase
BEST7003_RS09585	COG0583	DNA-binding transcription factor activity
BEST7003_RS09590	COG0604	alcohol dehydrogenase
BEST7003_RS09595	COG0493	'glutamate synthase
BEST7003_RS09600	COG0067	glutamate synthase
BEST7003_RS09600	COG0070	glutamate synthase
BEST7003_RS09600	COG0069	glutamate synthase activity
BEST7003_RS09605	COG0583	DNA-binding transcription factor activity
BEST7003_RS09610	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7003_RS09615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7003_RS09625	COG0300	oxidoreductase activity
BEST7003_RS09630	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BEST7003_RS09640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_RS09645	COG2814	Major facilitator Superfamily
BEST7003_RS09650	COG1070	Carbohydrate kinase
BEST7003_RS09655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BEST7003_RS09660	COG0243	molybdopterin cofactor binding
BEST7003_RS09685	COG5278	phosphoserine phosphatase activity
BEST7003_RS09685	COG0840	transmembrane signaling receptor activity
BEST7003_RS09690	COG2368	4-hydroxyphenylacetate
BEST7003_RS09695	COG4305	rare lipoprotein A
BEST7003_RS09700	COG3619	membrane
BEST7003_RS09705	COG3866	Pectate lyase
BEST7003_RS09710	COG2135	peptidase activity
BEST7003_RS09720	COG2140	Oxalate decarboxylase
BEST7003_RS09730	COG0456	acetyltransferase
BEST7003_RS09745	COG2720	vancomycin resistance protein
BEST7003_RS09755	COG3655	Transcriptional regulator
BEST7003_RS09760	COG3739	integral membrane protein
BEST7003_RS09765	COG0583	DNA-binding transcription factor activity
BEST7003_RS09770	COG0697	spore germination
BEST7003_RS09780	COG0693	protein deglycase activity
BEST7003_RS09785	COG2367	Beta-lactamase
BEST7003_RS09800	COG0574	Belongs to the PEP-utilizing enzyme family
BEST7003_RS09800	COG3848	Pyruvate phosphate dikinase
BEST7003_RS09805	COG0726	polysaccharide deacetylase
BEST7003_RS09810	COG2314	TM2 domain
BEST7003_RS09815	COG1396	sequence-specific DNA binding
BEST7003_RS09830	COG2135	peptidase activity
BEST7003_RS09850	COG0457	Tetratricopeptide repeat
BEST7003_RS09860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7003_RS09865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7003_RS09880	COG5290	Psort location Cytoplasmic, score
BEST7003_RS09900	COG5444	nuclease activity
BEST7003_RS09905	COG4282	regulation of fungal-type cell wall biogenesis
BEST7003_RS09910	COG1231	oxidoreductase activity
BEST7003_RS09915	COG5434	Belongs to the glycosyl hydrolase 28 family
BEST7003_RS09920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_RS09925	COG0662	Cupin 2, conserved barrel domain protein
BEST7003_RS09925	COG2207	Transcriptional regulator
BEST7003_RS09930	COG0456	acetyltransferase
BEST7003_RS09935	COG1309	transcriptional regulator
BEST7003_RS09940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_RS09945	COG3708	Transcriptional regulator
BEST7003_RS09950	COG2378	regulation of single-species biofilm formation
BEST7003_RS09960	COG0640	Transcriptional regulator
BEST7003_RS09965	COG0741	lytic transglycosylase activity
BEST7003_RS09970	COG2322	membrane
BEST7003_RS09985	COG1619	proteins homologs of microcin C7 resistance protein MccF
BEST7003_RS09990	COG3239	Fatty acid desaturase
BEST7003_RS09995	COG4585	Histidine kinase
BEST7003_RS10000	COG2197	response regulator
BEST7003_RS10005	COG3584	3D domain protein
BEST7003_RS10005	COG1388	LysM domain
BEST7003_RS10010	COG0514	ATP-dependent DNA helicase (RecQ)
BEST7003_RS10015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BEST7003_RS10020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BEST7003_RS10035	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7003_RS10060	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS10065	COG1657	PFAM Prenyltransferase squalene oxidase
BEST7003_RS10070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BEST7003_RS10075	COG0733	neurotransmitter:sodium symporter activity
BEST7003_RS10080	COG0385	Bile acid
BEST7003_RS10085	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7003_RS10090	COG0567	Dehydrogenase, E1 component
BEST7003_RS10095	COG4548	von Willebrand factor, type A
BEST7003_RS10100	COG0714	Associated with various cellular activities
BEST7003_RS10105	COG2032	superoxide dismutase activity
BEST7003_RS10110	COG0791	NLP P60 protein
BEST7003_RS10110	COG1388	LysM domain
BEST7003_RS10115	COG1819	glycosyl
BEST7003_RS10120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BEST7003_RS10125	COG0534	Mate efflux family protein
BEST7003_RS10130	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_RS10135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BEST7003_RS10140	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BEST7003_RS10150	COG2962	Rard protein
BEST7003_RS10165	COG2610	gluconate transmembrane transporter activity
BEST7003_RS10170	COG1942	4-Oxalocrotonate Tautomerase
BEST7003_RS10175	COG1733	regulation of RNA biosynthetic process
BEST7003_RS10180	COG0778	Nitroreductase
BEST7003_RS10185	COG0400	carboxylic ester hydrolase activity
BEST7003_RS10190	COG0346	lactoylglutathione lyase activity
BEST7003_RS10200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_RS10205	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS10205	COG0793	Belongs to the peptidase S41A family
BEST7003_RS10210	COG2226	methyltransferase
BEST7003_RS10220	COG1876	peptidase activity
BEST7003_RS10225	COG0813	purine-nucleoside phosphorylase activity
BEST7003_RS10235	COG0671	phosphoesterase, PA-phosphatase related
BEST7003_RS10250	COG4479	Belongs to the UPF0346 family
BEST7003_RS10260	COG1509	lysine 2,3-aminomutase activity
BEST7003_RS10265	COG0456	acetyltransferase
BEST7003_RS10270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7003_RS10275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BEST7003_RS10280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BEST7003_RS10285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BEST7003_RS10295	COG0456	acetyltransferase
BEST7003_RS10300	COG0463	Glycosyl transferase, family 2
BEST7003_RS10315	COG4641	Protein conserved in bacteria
BEST7003_RS10320	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
BEST7003_RS10325	COG1086	Polysaccharide biosynthesis protein
BEST7003_RS10330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BEST7003_RS10335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BEST7003_RS10340	COG1846	Transcriptional regulator
BEST7003_RS10345	COG0534	Mate efflux family protein
BEST7003_RS10355	COG4698	Protein conserved in bacteria
BEST7003_RS10360	COG2755	lipolytic protein G-D-S-L family
BEST7003_RS10365	COG1999	signal sequence binding
BEST7003_RS10375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BEST7003_RS10380	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BEST7003_RS10385	COG1272	protein, Hemolysin III
BEST7003_RS10390	COG0204	Acyl-transferase
BEST7003_RS10395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BEST7003_RS10400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BEST7003_RS10405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BEST7003_RS10415	COG2521	methyltransferase
BEST7003_RS10415	COG2136	Putative SAM-dependent methyltransferase
BEST7003_RS10425	COG0129	dihydroxy-acid dehydratase activity
BEST7003_RS10430	COG1413	lyase activity
BEST7003_RS10435	COG1418	mRNA catabolic process
BEST7003_RS10440	COG0386	Belongs to the glutathione peroxidase family
BEST7003_RS10445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BEST7003_RS10450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7003_RS10455	COG1278	Cold shock
BEST7003_RS10475	COG0328	RNA-DNA hybrid ribonuclease activity
BEST7003_RS10480	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BEST7003_RS10485	COG0328	RNA-DNA hybrid ribonuclease activity
BEST7003_RS10495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7003_RS10505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BEST7003_RS10510	COG1755	Isoprenylcysteine carboxyl methyltransferase
BEST7003_RS10515	COG3424	synthase
BEST7003_RS10520	COG2233	PERMEase
BEST7003_RS10525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7003_RS10530	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BEST7003_RS10540	COG0800	Aldolase
BEST7003_RS10545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_RS10550	COG1609	Transcriptional regulator
BEST7003_RS10555	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BEST7003_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS10565	COG1199	ATP-dependent helicase activity
BEST7003_RS10575	COG0116	Belongs to the methyltransferase superfamily
BEST7003_RS10585	COG4474	Belongs to the UPF0398 family
BEST7003_RS10590	COG3359	exonuclease
BEST7003_RS10595	COG1205	dead DEAH box helicase
BEST7003_RS10595	COG1111	helicase
BEST7003_RS10600	COG2190	(PTS) system
BEST7003_RS10605	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7003_RS10640	COG3331	DNA recombination
BEST7003_RS10645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7003_RS10645	COG4499	WXG100 protein secretion system (Wss), protein YukC
BEST7003_RS10655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BEST7003_RS10660	COG3935	DnaD domain protein
BEST7003_RS10665	COG0017	Asparaginyl-tRNA synthetase
BEST7003_RS10670	COG0436	Aminotransferase
BEST7003_RS10675	COG5353	protein conserved in bacteria
BEST7003_RS10680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BEST7003_RS10680	COG1199	ATP-dependent helicase activity
BEST7003_RS10685	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BEST7003_RS10690	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BEST7003_RS10695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BEST7003_RS10700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BEST7003_RS10700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BEST7003_RS10705	COG0617	tRNA 3'-terminal CCA addition
BEST7003_RS10710	COG0438	transferase activity, transferring glycosyl groups
BEST7003_RS10715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BEST7003_RS10720	COG1803	Methylglyoxal synthase
BEST7003_RS10725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BEST7003_RS10730	COG1694	Mazg nucleotide pyrophosphohydrolase
BEST7003_RS10735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_RS10745	COG4347	Protein of unknown function (DUF1405)
BEST7003_RS10750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BEST7003_RS10750	COG2010	Cytochrome c
BEST7003_RS10755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BEST7003_RS10760	COG0723	plastoquinol--plastocyanin reductase activity
BEST7003_RS10770	COG5582	Belongs to the UPF0302 family
BEST7003_RS10775	COG0457	Tetratricopeptide repeat
BEST7003_RS10780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BEST7003_RS10785	COG0287	Prephenate dehydrogenase
BEST7003_RS10790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BEST7003_RS10795	COG0159	tryptophan synthase activity
BEST7003_RS10800	COG0133	tryptophan synthase activity
BEST7003_RS10805	COG0135	phosphoribosylanthranilate isomerase activity
BEST7003_RS10815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BEST7003_RS10820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BEST7003_RS10825	COG4401	Chorismate mutase type I
BEST7003_RS10830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BEST7003_RS10835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BEST7003_RS10840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BEST7003_RS10845	COG0105	UTP biosynthetic process
BEST7003_RS10850	COG0142	geranyltranstransferase activity
BEST7003_RS10855	COG2226	methyltransferase
BEST7003_RS10860	COG0142	geranyltranstransferase activity
BEST7003_RS10870	COG0302	gtp cyclohydrolase
BEST7003_RS10875	COG0776	regulation of translation
BEST7003_RS10880	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BEST7003_RS10895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BEST7003_RS10900	COG1160	GTP binding
BEST7003_RS10920	COG1304	FMN binding
BEST7003_RS10925	COG0539	negative regulation of cytoplasmic translation
BEST7003_RS10930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BEST7003_RS10935	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BEST7003_RS10940	COG2959	enzyme of heme biosynthesis
BEST7003_RS10945	COG3773	Cell wall hydrolase
BEST7003_RS10945	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS10950	COG2339	peptidase activity
BEST7003_RS10955	COG0492	ferredoxin-NADP+ reductase activity
BEST7003_RS10960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7003_RS10965	COG4862	establishment of competence for transformation
BEST7003_RS10970	COG1408	metallophosphoesterase
BEST7003_RS10980	COG1388	LysM domain
BEST7003_RS10985	COG1266	CAAX protease self-immunity
BEST7003_RS10990	COG0514	ATP-dependent DNA helicase (RecQ)
BEST7003_RS10995	COG4955	Helix-turn-helix domain
BEST7003_RS11000	COG1141	Ferredoxin
BEST7003_RS11005	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BEST7003_RS11010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BEST7003_RS11015	COG0710	3-dehydroquinate dehydratase activity
BEST7003_RS11025	COG1595	DNA-templated transcription, initiation
BEST7003_RS11030	COG5002	protein histidine kinase activity
BEST7003_RS11035	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS11040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BEST7003_RS11045	COG1333	cytochrome c biogenesis protein
BEST7003_RS11050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS11055	COG1187	pseudouridine synthase activity
BEST7003_RS11060	COG0700	Nucleoside recognition
BEST7003_RS11065	COG2715	membrane protein required for spore maturation
BEST7003_RS11070	COG1686	Belongs to the peptidase S11 family
BEST7003_RS11080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BEST7003_RS11085	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BEST7003_RS11090	COG1547	Domain of unknown function (DUF309)
BEST7003_RS11095	COG0456	acetyltransferase
BEST7003_RS11100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BEST7003_RS11105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BEST7003_RS11105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BEST7003_RS11110	COG0307	riboflavin synthase, alpha
BEST7003_RS11115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BEST7003_RS11115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BEST7003_RS11125	COG0681	Belongs to the peptidase S26 family
BEST7003_RS11130	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BEST7003_RS11150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BEST7003_RS11155	COG4086	secreted protein
BEST7003_RS11160	COG0019	diaminopimelate decarboxylase activity
BEST7003_RS11165	COG0697	spore germination
BEST7003_RS11180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7003_RS11200	COG1191	sigma factor activity
BEST7003_RS11205	COG2172	sigma factor antagonist activity
BEST7003_RS11210	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_RS11215	COG1686	Belongs to the peptidase S11 family
BEST7003_RS11220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BEST7003_RS11225	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BEST7003_RS11230	COG4974	Belongs to the 'phage' integrase family
BEST7003_RS11240	COG0735	belongs to the Fur family
BEST7003_RS11245	COG1300	Membrane
BEST7003_RS11255	COG0281	malic enzyme
BEST7003_RS11260	COG1757	Na H antiporter
BEST7003_RS11265	COG1027	Aspartate ammonia-lyase
BEST7003_RS11270	COG0252	asparaginase activity
BEST7003_RS11275	COG1396	sequence-specific DNA binding
BEST7003_RS11280	COG1379	DNA repair
BEST7003_RS11285	COG0494	nUDIX hydrolase
BEST7003_RS11295	COG0667	Aldo Keto reductase
BEST7003_RS11305	COG1073	alpha beta
BEST7003_RS11315	COG4918	Iron-sulphur cluster biosynthesis
BEST7003_RS11320	COG0456	acetyltransferase
BEST7003_RS11320	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BEST7003_RS11325	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_RS11330	COG0456	acetyltransferase
BEST7003_RS11340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7003_RS11350	COG2211	Major facilitator Superfamily
BEST7003_RS11355	COG0346	lactoylglutathione lyase activity
BEST7003_RS11360	COG1072	(Pantothenic acid kinase))
BEST7003_RS11365	COG3048	D-serine ammonia-lyase activity
BEST7003_RS11370	COG0300	oxidoreductase activity
BEST7003_RS11375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_RS11380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7003_RS11385	COG4187	Peptidase family M20/M25/M40
BEST7003_RS11390	COG1902	pentaerythritol trinitrate reductase activity
BEST7003_RS11395	COG0596	Alpha beta hydrolase
BEST7003_RS11400	COG1234	tRNA 3'-trailer cleavage
BEST7003_RS11405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BEST7003_RS11410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BEST7003_RS11415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7003_RS11425	COG0706	membrane insertase activity
BEST7003_RS11430	COG3361	conserved protein (COG2071)
BEST7003_RS11435	COG2195	Cleaves the N-terminal amino acid of tripeptides
BEST7003_RS11440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BEST7003_RS11445	COG0346	lactoylglutathione lyase activity
BEST7003_RS11450	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7003_RS11455	COG4129	membrane
BEST7003_RS11460	COG1126	abc transporter atp-binding protein
BEST7003_RS11465	COG0765	amino acid transport
BEST7003_RS11470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_RS11480	COG1597	lipid kinase activity
BEST7003_RS11485	COG2814	Major facilitator Superfamily
BEST7003_RS11490	COG4978	Transcriptional regulator
BEST7003_RS11490	COG0789	Transcriptional regulator
BEST7003_RS11495	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7003_RS11500	COG0022	dehydrogenase e1 component
BEST7003_RS11505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7003_RS11510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7003_RS11515	COG3426	butyrate kinase activity
BEST7003_RS11520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7003_RS11525	COG0280	phosphate acetyltransferase
BEST7003_RS11530	COG3290	protein histidine kinase activity
BEST7003_RS11530	COG3829	transcription factor binding
BEST7003_RS11540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BEST7003_RS11545	COG2079	MmgE PrpD family protein
BEST7003_RS11550	COG0372	Belongs to the citrate synthase family
BEST7003_RS11555	COG1960	acyl-CoA dehydrogenase activity
BEST7003_RS11560	COG1250	3-hydroxyacyl-CoA dehydrogenase
BEST7003_RS11565	COG0183	Belongs to the thiolase family
BEST7003_RS11570	COG0584	glycerophosphoryl diester phosphodiesterase
BEST7003_RS11575	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS11585	COG1902	pentaerythritol trinitrate reductase activity
BEST7003_RS11590	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS11595	COG0750	zinc metalloprotease
BEST7003_RS11600	COG0497	DNA recombination
BEST7003_RS11605	COG1438	arginine binding
BEST7003_RS11610	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BEST7003_RS11615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BEST7003_RS11620	COG0142	geranyltranstransferase activity
BEST7003_RS11625	COG1722	exodeoxyribonuclease VII activity
BEST7003_RS11630	COG1570	exodeoxyribonuclease VII activity
BEST7003_RS11635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BEST7003_RS11640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BEST7003_RS11645	COG1302	Protein conserved in bacteria
BEST7003_RS11650	COG0439	Biotin carboxylase
BEST7003_RS11655	COG0511	ligase activity, forming carbon-carbon bonds
BEST7003_RS11695	COG3854	ATPases associated with a variety of cellular activities
BEST7003_RS11705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BEST7003_RS11710	COG0006	proline dipeptidase activity
BEST7003_RS11715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BEST7003_RS11725	COG3872	metal-dependent enzyme
BEST7003_RS11735	COG1752	Esterase of the alpha-beta hydrolase superfamily
BEST7003_RS11740	COG1321	iron dependent repressor
BEST7003_RS11745	COG0095	Lipoate-protein ligase
BEST7003_RS11750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7003_RS11755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BEST7003_RS11760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BEST7003_RS11765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BEST7003_RS11770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BEST7003_RS11785	COG1396	sequence-specific DNA binding
BEST7003_RS11795	COG0681	Belongs to the peptidase S26 family
BEST7003_RS11820	COG4940	Competence protein ComGF
BEST7003_RS11830	COG4970	Tfp pilus assembly protein FimT
BEST7003_RS11835	COG4537	Required for transformation and DNA binding
BEST7003_RS11840	COG1459	type II secretion system
BEST7003_RS11845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BEST7003_RS11850	COG0598	Magnesium transport protein CorA
BEST7003_RS11855	COG1253	flavin adenine dinucleotide binding
BEST7003_RS11860	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_RS11870	COG1393	Belongs to the ArsC family
BEST7003_RS11880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_RS11890	COG0011	TIGRFAM Protein of
BEST7003_RS11900	COG2866	Carboxypeptidase
BEST7003_RS11905	COG1368	sulfuric ester hydrolase activity
BEST7003_RS11910	COG1940	carbohydrate kinase activity
BEST7003_RS11915	COG4483	Protein conserved in bacteria
BEST7003_RS11920	COG0705	Rhomboid family
BEST7003_RS11920	COG0457	Tetratricopeptide repeat
BEST7003_RS11925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BEST7003_RS11930	COG0438	transferase activity, transferring glycosyl groups
BEST7003_RS11945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BEST7003_RS11950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7003_RS11955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7003_RS11960	COG0581	inorganic phosphate transmembrane transporter activity
BEST7003_RS11965	COG0573	inorganic phosphate transmembrane transporter activity
BEST7003_RS11970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BEST7003_RS11975	COG0768	penicillin binding
BEST7003_RS11980	COG0477	Major facilitator Superfamily
BEST7003_RS11985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BEST7003_RS11990	COG2839	Protein conserved in bacteria
BEST7003_RS11995	COG5521	maltodextrose utilization protein MalA
BEST7003_RS12005	COG1388	LysM domain
BEST7003_RS12010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BEST7003_RS12015	COG4709	membrane
BEST7003_RS12020	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BEST7003_RS12025	COG0735	belongs to the Fur family
BEST7003_RS12030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_RS12040	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BEST7003_RS12045	COG0513	Belongs to the DEAD box helicase family
BEST7003_RS12055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BEST7003_RS12060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BEST7003_RS12065	COG2384	SAM-dependent methyltransferase
BEST7003_RS12070	COG2010	Cytochrome c
BEST7003_RS12075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BEST7003_RS12080	COG0358	DNA primase activity
BEST7003_RS12085	COG1671	Belongs to the UPF0178 family
BEST7003_RS12090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BEST7003_RS12095	COG0517	IMP dehydrogenase activity
BEST7003_RS12100	COG0751	glycine-tRNA ligase activity
BEST7003_RS12105	COG0752	glycyl-tRNA synthetase alpha subunit
BEST7003_RS12110	COG1381	Involved in DNA repair and RecF pathway recombination
BEST7003_RS12115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BEST7003_RS12120	COG0295	cytidine deaminase activity
BEST7003_RS12125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BEST7003_RS12130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BEST7003_RS12135	COG1480	7TM receptor with intracellular HD hydrolase
BEST7003_RS12140	COG1702	phosphate starvation-inducible protein PhoH
BEST7003_RS12145	COG0561	phosphatase activity
BEST7003_RS12160	COG4864	UPF0365 protein
BEST7003_RS12165	COG1030	water channel activity
BEST7003_RS12170	COG1610	YqeY-like protein
BEST7003_RS12180	COG1283	sodium-dependent phosphate transmembrane transporter activity
BEST7003_RS12185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7003_RS12190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BEST7003_RS12195	COG2264	protein methyltransferase activity
BEST7003_RS12200	COG0484	heat shock protein binding
BEST7003_RS12205	COG0443	Heat shock 70 kDa protein
BEST7003_RS12210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BEST7003_RS12215	COG1420	regulation of RNA biosynthetic process
BEST7003_RS12220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BEST7003_RS12225	COG0481	GTPase activity
BEST7003_RS12235	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS12240	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BEST7003_RS12245	COG0268	Binds directly to 16S ribosomal RNA
BEST7003_RS12250	COG1466	dna polymerase III delta subunit
BEST7003_RS12260	COG0658	competence protein
BEST7003_RS12260	COG2333	competence protein COMEC
BEST7003_RS12265	COG2131	deaminase
BEST7003_RS12270	COG1596	polysaccharide export
BEST7003_RS12270	COG1555	photosystem II stabilization
BEST7003_RS12275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7003_RS12280	COG2226	methyltransferase
BEST7003_RS12285	COG0799	negative regulation of ribosome biogenesis
BEST7003_RS12290	COG1713	HD superfamily hydrolase involved in NAD metabolism
BEST7003_RS12295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BEST7003_RS12300	COG1534	Rna-binding protein
BEST7003_RS12305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BEST7003_RS12310	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BEST7003_RS12315	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BEST7003_RS12325	COG2755	lipolytic protein G-D-S-L family
BEST7003_RS12330	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS12330	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS12335	COG0398	Pfam SNARE associated Golgi protein
BEST7003_RS12340	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BEST7003_RS12350	COG3209	COG3209 Rhs family protein
BEST7003_RS12360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7003_RS12365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7003_RS12370	COG0798	PFAM Bile acid sodium symporter
BEST7003_RS12375	COG0346	lactoylglutathione lyase activity
BEST7003_RS12380	COG0640	Transcriptional regulator
BEST7003_RS12385	COG3403	YqcI/YcgG family
BEST7003_RS12390	COG0457	Tetratricopeptide repeat
BEST7003_RS12400	COG5444	nuclease activity
BEST7003_RS12420	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS12420	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS12425	COG4824	toxin secretion phage lysis holin
BEST7003_RS12455	COG3778	Protein conserved in bacteria
BEST7003_RS12460	COG3299	homolog of phage Mu protein gp47
BEST7003_RS12465	COG3628	GPW Gp25 family protein
BEST7003_RS12475	COG4193	domain, Protein
BEST7003_RS12480	COG1652	LysM domain
BEST7003_RS12485	COG5280	Phage tail tape measure protein TP901
BEST7003_RS12485	COG3953	SLT domain
BEST7003_RS12540	COG4653	Phage capsid family
BEST7003_RS12545	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BEST7003_RS12555	COG2369	cell adhesion
BEST7003_RS12560	COG5518	Phage portal protein
BEST7003_RS12565	COG1783	phage Terminase large subunit
BEST7003_RS12570	COG5484	DNA packaging
BEST7003_RS12580	COG3677	Transposase
BEST7003_RS12595	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BEST7003_RS12600	COG1484	DNA-dependent DNA replication
BEST7003_RS12605	COG3935	DnaD domain protein
BEST7003_RS12610	COG3723	Recombinational DNA repair protein, rece pathway
BEST7003_RS12615	COG5377	YqaJ viral recombinase family
BEST7003_RS12635	COG1476	TRANSCRIPTIONal
BEST7003_RS12640	COG3620	sequence-specific DNA binding
BEST7003_RS12645	COG0563	adenylate kinase activity
BEST7003_RS12650	COG2856	Zn peptidase
BEST7003_RS12660	COG3223	Belongs to the PsiE family
BEST7003_RS12665	COG0642	Histidine kinase
BEST7003_RS12665	COG5002	protein histidine kinase activity
BEST7003_RS12670	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS12675	COG2311	Membrane
BEST7003_RS12680	COG0454	-acetyltransferase
BEST7003_RS12685	COG2249	NAD(P)H dehydrogenase (quinone) activity
BEST7003_RS12695	COG0730	response to heat
BEST7003_RS12700	COG0425	Belongs to the sulfur carrier protein TusA family
BEST7003_RS12705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7003_RS12705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_RS12715	COG0425	Belongs to the sulfur carrier protein TusA family
BEST7003_RS12715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7003_RS12720	COG2210	Belongs to the sulfur carrier protein TusA family
BEST7003_RS12725	COG1937	Protein conserved in bacteria
BEST7003_RS12730	COG0662	Cupin 2, conserved barrel domain protein
BEST7003_RS12740	COG4978	Transcriptional regulator
BEST7003_RS12740	COG0789	Transcriptional regulator
BEST7003_RS12745	COG2814	Major facilitator Superfamily
BEST7003_RS12750	COG0456	acetyltransferase
BEST7003_RS12755	COG1253	flavin adenine dinucleotide binding
BEST7003_RS12760	COG0697	spore germination
BEST7003_RS12765	COG0583	DNA-binding transcription factor activity
BEST7003_RS12770	COG2072	flavoprotein involved in K transport
BEST7003_RS12775	COG1230	cation diffusion facilitator family transporter
BEST7003_RS12780	COG1942	4-Oxalocrotonate Tautomerase
BEST7003_RS12785	COG0583	DNA-binding transcription factor activity
BEST7003_RS12795	COG1114	Component of the transport system for branched-chain amino acids
BEST7003_RS12800	COG1687	branched-chain amino acid
BEST7003_RS12805	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BEST7003_RS12810	COG1522	sequence-specific DNA binding
BEST7003_RS12815	COG2732	(Barnase) inhibitor
BEST7003_RS12820	COG2124	cytochrome p450
BEST7003_RS12825	COG1335	isochorismatase
BEST7003_RS12835	COG2318	DinB family
BEST7003_RS12845	COG2070	2-Nitropropane dioxygenase
BEST7003_RS12850	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BEST7003_RS12860	COG3443	Belongs to the bacterial solute-binding protein 9 family
BEST7003_RS12865	COG1595	DNA-templated transcription, initiation
BEST7003_RS12870	COG0667	Aldo Keto reductase
BEST7003_RS12875	COG2851	Citrate transporter
BEST7003_RS12880	COG0583	DNA-binding transcription factor activity
BEST7003_RS12885	COG2828	Protein conserved in bacteria
BEST7003_RS12890	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS12895	COG5566	PFAM Mor transcription activator
BEST7003_RS12900	COG0596	Alpha beta hydrolase
BEST7003_RS12905	COG4991	sh3 domain protein
BEST7003_RS12910	COG4991	sh3 domain protein
BEST7003_RS12915	COG0346	lactoylglutathione lyase activity
BEST7003_RS12925	COG5577	PFAM Coat F domain
BEST7003_RS12930	COG1063	alcohol dehydrogenase
BEST7003_RS12940	COG5577	PFAM Coat F domain
BEST7003_RS12945	COG0789	Transcriptional regulator
BEST7003_RS12955	COG1064	alcohol dehydrogenase
BEST7003_RS12960	COG0693	protein deglycase activity
BEST7003_RS12965	COG1621	beta-fructofuranosidase activity
BEST7003_RS12970	COG3716	PTS system mannose fructose sorbose family IID component
BEST7003_RS12975	COG3715	PTS system
BEST7003_RS12980	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS12985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_RS12990	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BEST7003_RS12990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BEST7003_RS12995	COG1113	amino acid transport
BEST7003_RS13000	COG1280	lysine exporter protein (LysE YggA)
BEST7003_RS13005	COG1378	Sugar-specific transcriptional regulator TrmB
BEST7003_RS13010	COG1595	DNA-templated transcription, initiation
BEST7003_RS13020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BEST7003_RS13020	COG2755	lipolytic protein G-D-S-L family
BEST7003_RS13030	COG2124	cytochrome p450
BEST7003_RS13030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7003_RS13035	COG1309	transcriptional regulator
BEST7003_RS13040	COG2226	methyltransferase
BEST7003_RS13045	COG2116	formate transmembrane transporter activity
BEST7003_RS13050	COG5609	conserved protein (DUF2294)
BEST7003_RS13055	COG3383	formate dehydrogenase (NAD+) activity
BEST7003_RS13060	COG2427	Protein of unknown function (DUF1641)
BEST7003_RS13070	COG0626	cystathionine gamma-synthase activity
BEST7003_RS13075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7003_RS13080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BEST7003_RS13085	COG2226	methyltransferase
BEST7003_RS13100	COG0768	penicillin binding
BEST7003_RS13105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BEST7003_RS13110	COG0572	uridine kinase
BEST7003_RS13115	COG0826	peptidase U32
BEST7003_RS13120	COG0826	peptidase U32
BEST7003_RS13125	COG4122	O-methyltransferase activity
BEST7003_RS13130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BEST7003_RS13135	COG3906	Belongs to the UPF0473 family
BEST7003_RS13140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BEST7003_RS13145	COG4472	Bacterial protein of unknown function (DUF965)
BEST7003_RS13150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BEST7003_RS13155	COG0628	permease
BEST7003_RS13160	COG1126	abc transporter atp-binding protein
BEST7003_RS13165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_RS13170	COG0765	amino acid transport
BEST7003_RS13175	COG0765	amino acid transport
BEST7003_RS13185	COG3881	PFAM PRC-barrel domain
BEST7003_RS13190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BEST7003_RS13195	COG0457	Tetratricopeptide repeat
BEST7003_RS13200	COG0482	sulfurtransferase activity
BEST7003_RS13205	COG1104	cysteine desulfurase activity
BEST7003_RS13210	COG1959	2 iron, 2 sulfur cluster binding
BEST7003_RS13215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BEST7003_RS13220	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BEST7003_RS13225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BEST7003_RS13230	COG0124	histidyl-tRNA synthetase
BEST7003_RS13235	COG4991	sh3 domain protein
BEST7003_RS13235	COG3103	Sh3 type 3 domain protein
BEST7003_RS13235	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS13240	COG1490	D-aminoacyl-tRNA deacylase activity
BEST7003_RS13245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BEST7003_RS13250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7003_RS13255	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BEST7003_RS13255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BEST7003_RS13260	COG5416	Lipopolysaccharide assembly protein A domain
BEST7003_RS13265	COG0490	domain, Protein
BEST7003_RS13270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BEST7003_RS13270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BEST7003_RS13280	COG2244	polysaccharide biosynthetic process
BEST7003_RS13285	COG2323	membrane
BEST7003_RS13295	COG1862	Preprotein translocase
BEST7003_RS13300	COG0343	queuine tRNA-ribosyltransferase activity
BEST7003_RS13305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BEST7003_RS13315	COG2255	four-way junction helicase activity
BEST7003_RS13320	COG0632	four-way junction helicase activity
BEST7003_RS13330	COG2814	Major facilitator Superfamily
BEST7003_RS13335	COG0673	inositol 2-dehydrogenase activity
BEST7003_RS13340	COG2112	serine threonine protein kinase
BEST7003_RS13355	COG1115	amino acid carrier protein
BEST7003_RS13360	COG0217	transcriptional regulatory protein
BEST7003_RS13370	COG1388	LysM domain
BEST7003_RS13375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BEST7003_RS13380	COG0157	Belongs to the NadC ModD family
BEST7003_RS13385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BEST7003_RS13390	COG1104	cysteine desulfurase activity
BEST7003_RS13395	COG1827	regulation of RNA biosynthetic process
BEST7003_RS13400	COG0077	Prephenate dehydratase
BEST7003_RS13405	COG4492	Belongs to the UPF0735 family
BEST7003_RS13410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BEST7003_RS13415	COG3290	protein histidine kinase activity
BEST7003_RS13420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BEST7003_RS13425	COG2868	ribosomal protein
BEST7003_RS13430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BEST7003_RS13435	COG1994	Peptidase M50
BEST7003_RS13440	COG0739	heme binding
BEST7003_RS13445	COG2894	cell division
BEST7003_RS13450	COG0850	regulation of cytokinetic process
BEST7003_RS13455	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BEST7003_RS13465	COG1077	Cell shape determining protein MreB Mrl
BEST7003_RS13470	COG2003	Belongs to the UPF0758 family
BEST7003_RS13475	COG0424	maF-like protein
BEST7003_RS13485	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BEST7003_RS13490	COG0285	dihydrofolate synthase activity
BEST7003_RS13495	COG0525	valine-tRNA ligase activity
BEST7003_RS13505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_RS13510	COG1388	LysM domain
BEST7003_RS13515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BEST7003_RS13520	COG0113	porphobilinogen synthase activity
BEST7003_RS13525	COG1587	Uroporphyrinogen-III synthase
BEST7003_RS13530	COG0181	hydroxymethylbilane synthase activity
BEST7003_RS13535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BEST7003_RS13540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BEST7003_RS13550	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BEST7003_RS13555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BEST7003_RS13560	COG1067	ATP-dependent peptidase activity
BEST7003_RS13560	COG0470	DNA polymerase III
BEST7003_RS13565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BEST7003_RS13570	COG0544	peptidyl-prolyl cis-trans isomerase activity
BEST7003_RS13575	COG1477	protein flavinylation
BEST7003_RS13575	COG0457	Tetratricopeptide repeat
BEST7003_RS13580	COG0066	3-isopropylmalate dehydratase activity
BEST7003_RS13585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BEST7003_RS13590	COG0473	3-isopropylmalate dehydrogenase activity
BEST7003_RS13595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BEST7003_RS13600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BEST7003_RS13605	COG0440	acetolactate synthase activity
BEST7003_RS13610	COG0028	Belongs to the TPP enzyme family
BEST7003_RS13620	COG0454	-acetyltransferase
BEST7003_RS13625	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BEST7003_RS13635	COG0622	Phosphoesterase
BEST7003_RS13640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BEST7003_RS13645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BEST7003_RS13650	COG5401	PFAM Sporulation and spore germination
BEST7003_RS13655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BEST7003_RS13660	COG1846	Transcriptional regulator
BEST7003_RS13665	COG2197	response regulator
BEST7003_RS13670	COG0824	Thioesterase
BEST7003_RS13675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BEST7003_RS13680	COG1053	succinate dehydrogenase
BEST7003_RS13685	COG2009	succinate dehydrogenase
BEST7003_RS13690	COG1719	4-vinyl reductase, 4VR
BEST7003_RS13695	COG0527	aspartate kinase activity
BEST7003_RS13700	COG0322	excinuclease ABC activity
BEST7003_RS13705	COG3118	belongs to the thioredoxin family
BEST7003_RS13710	COG3534	alpha-L-arabinofuranosidase
BEST7003_RS13715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BEST7003_RS13720	COG2086	electron transfer activity
BEST7003_RS13725	COG1024	Enoyl-CoA hydratase
BEST7003_RS13730	COG1309	transcriptional regulator
BEST7003_RS13735	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_RS13740	COG3766	membrane
BEST7003_RS13745	COG1193	negative regulation of DNA recombination
BEST7003_RS13750	COG1796	DNA polymerase
BEST7003_RS13750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BEST7003_RS13755	COG1286	toxin biosynthetic process
BEST7003_RS13760	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BEST7003_RS13765	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BEST7003_RS13770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_RS13770	COG0072	phenylalanine-tRNA ligase activity
BEST7003_RS13775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BEST7003_RS13785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BEST7003_RS13795	COG3835	regulator
BEST7003_RS13800	COG0277	FAD linked oxidase domain protein
BEST7003_RS13805	COG0247	lactate metabolic process
BEST7003_RS13810	COG0346	lactoylglutathione lyase activity
BEST7003_RS13815	COG1966	Carbon starvation protein
BEST7003_RS13820	COG3534	alpha-L-arabinofuranosidase
BEST7003_RS13825	COG0395	ABC-type sugar transport system, permease component
BEST7003_RS13830	COG1175	transmembrane transport
BEST7003_RS13835	COG1653	transport
BEST7003_RS13840	COG0371	Dehydrogenase
BEST7003_RS13845	COG0647	UMP catabolic process
BEST7003_RS13850	COG0235	Class ii aldolase
BEST7003_RS13855	COG1069	ribulokinase activity
BEST7003_RS13860	COG2160	L-arabinose isomerase activity
BEST7003_RS13865	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7003_RS13870	COG1363	Peptidase, m42
BEST7003_RS13880	COG3326	Membrane
BEST7003_RS13885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BEST7003_RS13890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BEST7003_RS13895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BEST7003_RS13905	COG1346	cytolysis
BEST7003_RS13910	COG1380	Effector of murein hydrolase LrgA
BEST7003_RS13915	COG3279	Response regulator of the LytR AlgR family
BEST7003_RS13920	COG3275	phosphorelay sensor kinase activity
BEST7003_RS13925	COG1011	Hydrolase
BEST7003_RS13930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BEST7003_RS13940	COG0398	Pfam SNARE associated Golgi protein
BEST7003_RS13945	COG1484	DNA-dependent DNA replication
BEST7003_RS13950	COG3611	Membrane attachment protein
BEST7003_RS13955	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BEST7003_RS13960	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BEST7003_RS13965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BEST7003_RS13970	COG1733	regulation of RNA biosynthetic process
BEST7003_RS13975	COG2814	Major facilitator Superfamily
BEST7003_RS13980	COG0656	L-ascorbic acid biosynthetic process
BEST7003_RS13985	COG0237	dephospho-CoA kinase activity
BEST7003_RS13990	COG1971	Probably functions as a manganese efflux pump
BEST7003_RS13995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BEST7003_RS14000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7003_RS14000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7003_RS14005	COG5002	protein histidine kinase activity
BEST7003_RS14010	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS14015	COG0039	L-malate dehydrogenase activity
BEST7003_RS14020	COG0538	isocitrate dehydrogenase activity
BEST7003_RS14025	COG0372	Belongs to the citrate synthase family
BEST7003_RS14030	COG2707	UPF0756 membrane protein
BEST7003_RS14035	COG0628	permease
BEST7003_RS14040	COG3030	protein affecting phage T7 exclusion by the F plasmid
BEST7003_RS14045	COG0469	pyruvate kinase activity
BEST7003_RS14050	COG0205	6-phosphofructokinase activity
BEST7003_RS14055	COG0825	malonyl-CoA metabolic process
BEST7003_RS14060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BEST7003_RS14065	COG0281	malic enzyme
BEST7003_RS14070	COG0587	DNA-directed DNA polymerase activity
BEST7003_RS14090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BEST7003_RS14100	COG4109	DRTGG domain
BEST7003_RS14105	COG0730	response to heat
BEST7003_RS14110	COG1473	amidohydrolase
BEST7003_RS14115	COG0196	riboflavin kinase activity
BEST7003_RS14120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_RS14125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BEST7003_RS14130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_RS14135	COG1126	abc transporter atp-binding protein
BEST7003_RS14140	COG0765	amino acid transport
BEST7003_RS14145	COG0765	amino acid transport
BEST7003_RS14150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_RS14155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_RS14160	COG0454	-acetyltransferase
BEST7003_RS14165	COG0583	DNA-binding transcription factor activity
BEST7003_RS14170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BEST7003_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS14180	COG0165	Argininosuccinate lyase
BEST7003_RS14190	COG0521	Mo-molybdopterin cofactor biosynthetic process
BEST7003_RS14195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BEST7003_RS14200	COG0827	DNA restriction-modification system
BEST7003_RS14205	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BEST7003_RS14210	COG3874	Sporulation protein YtfJ
BEST7003_RS14220	COG1714	RDD family
BEST7003_RS14225	COG0616	signal peptide processing
BEST7003_RS14230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BEST7003_RS14235	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BEST7003_RS14240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BEST7003_RS14250	COG0301	tRNA thio-modification
BEST7003_RS14255	COG1104	cysteine desulfurase activity
BEST7003_RS14260	COG1114	Component of the transport system for branched-chain amino acids
BEST7003_RS14265	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BEST7003_RS14270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BEST7003_RS14275	COG1309	transcriptional regulator
BEST7003_RS14280	COG1956	GAF domain-containing protein
BEST7003_RS14285	COG2199	diguanylate cyclase activity
BEST7003_RS14285	COG2203	Gaf domain
BEST7003_RS14290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BEST7003_RS14295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BEST7003_RS14300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BEST7003_RS14305	COG0454	-acetyltransferase
BEST7003_RS14310	COG0517	IMP dehydrogenase activity
BEST7003_RS14315	COG0123	including yeast histone deacetylase and acetoin utilization protein
BEST7003_RS14320	COG1360	Flagellar Motor Protein
BEST7003_RS14325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BEST7003_RS14330	COG1609	Transcriptional regulator
BEST7003_RS14335	COG1605	Chorismate mutase
BEST7003_RS14335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BEST7003_RS14340	COG3118	belongs to the thioredoxin family
BEST7003_RS14345	COG4980	gas vesicle protein
BEST7003_RS14350	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BEST7003_RS14355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BEST7003_RS14360	COG1674	ftsk spoiiie
BEST7003_RS14365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_RS14370	COG4848	Belongs to the UPF0354 family
BEST7003_RS14375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS14385	COG1363	Peptidase, m42
BEST7003_RS14390	COG5584	Small secreted protein
BEST7003_RS14395	COG0281	malic enzyme
BEST7003_RS14400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_RS14405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BEST7003_RS14415	COG0510	thiamine kinase activity
BEST7003_RS14420	COG1523	belongs to the glycosyl hydrolase 13 family
BEST7003_RS14425	COG1597	lipid kinase activity
BEST7003_RS14435	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BEST7003_RS14440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7003_RS14445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7003_RS14450	COG2252	PERMEase
BEST7003_RS14455	COG4473	ABC transporter
BEST7003_RS14460	COG1131	(ABC) transporter
BEST7003_RS14465	COG1349	DNA-binding transcription factor activity
BEST7003_RS14470	COG1187	pseudouridine synthase activity
BEST7003_RS14475	COG2244	polysaccharide biosynthetic process
BEST7003_RS14480	COG2081	HI0933 family
BEST7003_RS14485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BEST7003_RS14495	COG5578	integral membrane protein
BEST7003_RS14500	COG0673	inositol 2-dehydrogenase activity
BEST7003_RS14505	COG1653	transport
BEST7003_RS14510	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BEST7003_RS14515	COG4209	transmembrane transport
BEST7003_RS14520	COG2207	Transcriptional regulator
BEST7003_RS14525	COG1653	transport
BEST7003_RS14530	COG0395	ABC-type sugar transport system, permease component
BEST7003_RS14535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7003_RS14540	COG2124	cytochrome p450
BEST7003_RS14545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BEST7003_RS14550	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BEST7003_RS14555	COG0156	8-amino-7-oxononanoate synthase activity
BEST7003_RS14560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BEST7003_RS14565	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
BEST7003_RS14570	COG1073	alpha beta
BEST7003_RS14575	COG1609	Transcriptional regulator
BEST7003_RS14580	COG1653	transport
BEST7003_RS14585	COG1175	transmembrane transport
BEST7003_RS14590	COG0395	ABC-type sugar transport system, permease component
BEST7003_RS14595	COG1486	melibiose metabolic process
BEST7003_RS14600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7003_RS14605	COG0495	leucyl-tRNA aminoacylation
BEST7003_RS14615	COG2202	Pas domain
BEST7003_RS14615	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_RS14620	COG2814	Major facilitator Superfamily
BEST7003_RS14625	COG2433	Pfam Transposase IS66
BEST7003_RS14630	COG0577	efflux transmembrane transporter activity
BEST7003_RS14635	COG1136	(ABC) transporter
BEST7003_RS14640	COG2205	protein histidine kinase activity
BEST7003_RS14645	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS14650	COG0577	efflux transmembrane transporter activity
BEST7003_RS14655	COG1136	(ABC) transporter
BEST7003_RS14670	COG1131	(ABC) transporter
BEST7003_RS14675	COG1725	Transcriptional regulator
BEST7003_RS14685	COG1242	4 iron, 4 sulfur cluster binding
BEST7003_RS14690	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BEST7003_RS14700	COG2267	carboxylic ester hydrolase activity
BEST7003_RS14705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BEST7003_RS14710	COG1113	amino acid transport
BEST7003_RS14715	COG0367	asparagine synthase
BEST7003_RS14720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BEST7003_RS14725	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BEST7003_RS14735	COG1506	peptidase
BEST7003_RS14740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7003_RS14745	COG1116	anion transmembrane transporter activity
BEST7003_RS14750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BEST7003_RS14755	COG0494	nUDIX hydrolase
BEST7003_RS14760	COG4824	toxin secretion phage lysis holin
BEST7003_RS14765	COG0783	Belongs to the Dps family
BEST7003_RS14780	COG1854	S-ribosylhomocysteine lyase activity
BEST7003_RS14785	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BEST7003_RS14790	COG0288	reversible hydration of carbon dioxide
BEST7003_RS14795	COG0254	rRNA binding
BEST7003_RS14800	COG1271	oxidase subunit
BEST7003_RS14805	COG1294	oxidase, subunit
BEST7003_RS14810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7003_RS14815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7003_RS14815	COG1321	iron dependent repressor
BEST7003_RS14820	COG1121	(ABC) transporter
BEST7003_RS14825	COG0803	Belongs to the bacterial solute-binding protein 9 family
BEST7003_RS14830	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7003_RS14835	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_RS14840	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BEST7003_RS14845	COG0596	Alpha beta hydrolase
BEST7003_RS14850	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BEST7003_RS14855	COG1169	isochorismate synthase
BEST7003_RS14860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BEST7003_RS14865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7003_RS14870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7003_RS14875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7003_RS14880	COG0438	transferase activity, transferring glycosyl groups
BEST7003_RS14890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_RS14895	COG0438	transferase activity, transferring glycosyl groups
BEST7003_RS14900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_RS14905	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BEST7003_RS14910	COG0058	SHG alpha-glucan phosphorylase activity
BEST7003_RS14915	COG0297	glycogen (starch) synthase activity
BEST7003_RS14920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7003_RS14925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7003_RS14930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BEST7003_RS15085	COG3859	Proton-coupled thiamine transporter YuaJ
BEST7003_RS15090	COG1247	-acetyltransferase
BEST7003_RS15095	COG2268	Band 7 protein
BEST7003_RS15100	COG1585	Membrane protein implicated in regulation of membrane protease activity
BEST7003_RS15105	COG2318	DinB family
BEST7003_RS15115	COG1454	alcohol dehydrogenase
BEST7003_RS15120	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS15125	COG1510	regulation of RNA biosynthetic process
BEST7003_RS15135	COG0569	domain protein
BEST7003_RS15140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BEST7003_RS15145	COG4682	membrane
BEST7003_RS15150	COG1705	Flagellar rod assembly protein muramidase FlgJ
BEST7003_RS15155	COG0477	Major facilitator Superfamily
BEST7003_RS15160	COG5553	Cysteine dioxygenase type I
BEST7003_RS15170	COG1968	undecaprenyl-diphosphatase activity
BEST7003_RS15175	COG0628	permease
BEST7003_RS15180	COG0673	inositol 2-dehydrogenase activity
BEST7003_RS15185	COG4806	L-rhamnose isomerase
BEST7003_RS15190	COG3254	rhamnose metabolic process
BEST7003_RS15195	COG1070	Carbohydrate kinase
BEST7003_RS15200	COG1349	DNA-binding transcription factor activity
BEST7003_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS15205	COG3347	Dehydrogenase
BEST7003_RS15210	COG0840	transmembrane signaling receptor activity
BEST7003_RS15215	COG0840	transmembrane signaling receptor activity
BEST7003_RS15220	COG0840	transmembrane signaling receptor activity
BEST7003_RS15225	COG0840	transmembrane signaling receptor activity
BEST7003_RS15240	COG0432	Pfam Uncharacterised protein family UPF0047
BEST7003_RS15245	COG0366	Alpha amylase catalytic
BEST7003_RS15250	COG1253	flavin adenine dinucleotide binding
BEST7003_RS15255	COG2738	Putative neutral zinc metallopeptidase
BEST7003_RS15270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BEST7003_RS15285	COG0166	Belongs to the GPI family
BEST7003_RS15290	COG1979	alcohol dehydrogenase
BEST7003_RS15295	COG1979	alcohol dehydrogenase
BEST7003_RS15300	COG2155	Conserved Protein
BEST7003_RS15305	COG1098	S1 RNA binding domain
BEST7003_RS15310	COG0436	Aminotransferase
BEST7003_RS15315	COG1522	sequence-specific DNA binding
BEST7003_RS15320	COG2267	carboxylic ester hydrolase activity
BEST7003_RS15330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BEST7003_RS15335	COG2205	protein histidine kinase activity
BEST7003_RS15345	COG5018	Exonuclease
BEST7003_RS15355	COG2814	Major facilitator Superfamily
BEST7003_RS15360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7003_RS15365	COG3011	Protein conserved in bacteria
BEST7003_RS15375	COG3290	protein histidine kinase activity
BEST7003_RS15380	COG4565	transcriptional regulatory protein
BEST7003_RS15385	COG1744	ABC transporter substrate-binding protein PnrA-like
BEST7003_RS15390	COG3845	ABC transporter
BEST7003_RS15395	COG4603	Belongs to the binding-protein-dependent transport system permease family
BEST7003_RS15400	COG1079	Belongs to the binding-protein-dependent transport system permease family
BEST7003_RS15405	COG3493	citrate carrier protein
BEST7003_RS15415	COG2111	Na H antiporter
BEST7003_RS15415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BEST7003_RS15420	COG2111	Na H antiporter
BEST7003_RS15425	COG1006	Multisubunit Na H antiporter MnhC subunit
BEST7003_RS15430	COG0651	ATP synthesis coupled electron transport
BEST7003_RS15435	COG1863	multisubunit Na H antiporter MnhE subunit
BEST7003_RS15440	COG2212	antiporter activity
BEST7003_RS15445	COG1320	monovalent cation:proton antiporter activity
BEST7003_RS15450	COG2050	protein possibly involved in aromatic compounds catabolism
BEST7003_RS15455	COG2197	response regulator
BEST7003_RS15460	COG4585	Histidine kinase
BEST7003_RS15470	COG0142	geranyltranstransferase activity
BEST7003_RS15485	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BEST7003_RS15490	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BEST7003_RS15495	COG1335	isochorismatase
BEST7003_RS15500	COG5506	Protein of unknown function (DUF1694)
BEST7003_RS15515	COG0628	permease
BEST7003_RS15530	COG1418	mRNA catabolic process
BEST7003_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS15545	COG1511	domain protein
BEST7003_RS15550	COG0433	COG0433 Predicted ATPase
BEST7003_RS15550	COG1674	ftsk spoiiie
BEST7003_RS15555	COG4499	WXG100 protein secretion system (Wss), protein YukC
BEST7003_RS15560	COG5417	Belongs to the EsaB family
BEST7003_RS15565	COG4842	Belongs to the WXG100 family
BEST7003_RS15570	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BEST7003_RS15570	COG2508	Transcriptional regulator
BEST7003_RS15575	COG0686	Belongs to the AlaDH PNT family
BEST7003_RS15580	COG5634	Uncharacterized conserved protein (DUF2278)
BEST7003_RS15585	COG3251	PFAM MbtH domain protein
BEST7003_RS15590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_RS15595	COG1535	isochorismatase
BEST7003_RS15595	COG3433	isochorismatase activity
BEST7003_RS15600	COG1021	2,3-dihydroxybenzoate-AMP ligase
BEST7003_RS15605	COG1169	isochorismate synthase
BEST7003_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS15615	COG2819	hydrolase of the alpha beta superfamily
BEST7003_RS15620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BEST7003_RS15625	COG1268	BioY protein
BEST7003_RS15630	COG2056	Na+-H+ antiporter family
BEST7003_RS15635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BEST7003_RS15640	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BEST7003_RS15645	COG3584	3D domain protein
BEST7003_RS15655	COG1252	NADH dehydrogenase
BEST7003_RS15660	COG0492	ferredoxin-NADP+ reductase activity
BEST7003_RS15665	COG0516	GMP reductase activity
BEST7003_RS15670	COG2808	Putative FMN-binding domain
BEST7003_RS15675	COG0456	acetyltransferase
BEST7003_RS15680	COG0316	Belongs to the HesB IscA family
BEST7003_RS15685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BEST7003_RS15690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BEST7003_RS15695	COG4844	belongs to the
BEST7003_RS15700	COG1252	NADH dehydrogenase
BEST7003_RS15705	COG4837	Protein of unknown function (DUF1462)
BEST7003_RS15710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BEST7003_RS15715	COG0823	Involved in the tonB-independent uptake of proteins
BEST7003_RS15715	COG1506	peptidase
BEST7003_RS15715	COG4946	Tricorn protease homolog
BEST7003_RS15720	COG0083	homoserine kinase activity
BEST7003_RS15725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BEST7003_RS15730	COG0460	homoserine dehydrogenase
BEST7003_RS15735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_RS15740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BEST7003_RS15745	COG0647	UMP catabolic process
BEST7003_RS15750	COG2445	Protein of unknown function DUF86
BEST7003_RS15755	COG4470	Protein conserved in bacteria
BEST7003_RS15765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BEST7003_RS15770	COG0739	heme binding
BEST7003_RS15780	COG3377	Domain of unknown function (DUF1805)
BEST7003_RS15785	COG0737	Belongs to the 5'-nucleotidase family
BEST7003_RS15790	COG0730	response to heat
BEST7003_RS15795	COG1801	Protein of unknown function DUF72
BEST7003_RS15805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BEST7003_RS15810	COG2508	Transcriptional regulator
BEST7003_RS15815	COG2233	PERMEase
BEST7003_RS15820	COG2233	PERMEase
BEST7003_RS15825	COG3648	Uricase
BEST7003_RS15825	COG3195	allantoin biosynthetic process
BEST7003_RS15830	COG2351	hydroxyisourate hydrolase activity
BEST7003_RS15840	COG2080	2 iron, 2 sulfur cluster binding
BEST7003_RS15845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BEST7003_RS15850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BEST7003_RS15855	COG2068	MobA-Related Protein
BEST7003_RS15860	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BEST7003_RS15865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BEST7003_RS15870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7003_RS15875	COG2356	endonuclease I
BEST7003_RS15880	COG3842	ATPase activity
BEST7003_RS15885	COG2188	Transcriptional regulator
BEST7003_RS15890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_RS15895	COG0395	ABC-type sugar transport system, permease component
BEST7003_RS15900	COG1175	transmembrane transport
BEST7003_RS15905	COG1653	transport
BEST7003_RS15910	COG2222	sugar isomerase
BEST7003_RS15915	COG0322	excinuclease ABC activity
BEST7003_RS15920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7003_RS15935	COG0346	lactoylglutathione lyase activity
BEST7003_RS15940	COG0640	Transcriptional regulator
BEST7003_RS15945	COG0719	Fe-S assembly protein
BEST7003_RS15950	COG0822	iron-sulfur transferase activity
BEST7003_RS15955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BEST7003_RS15960	COG0719	Fe-S assembly protein
BEST7003_RS15965	COG0396	ATPase activity
BEST7003_RS15970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BEST7003_RS15975	COG1464	Belongs to the NlpA lipoprotein family
BEST7003_RS15980	COG2011	ABC-type metal ion transport system permease component
BEST7003_RS15985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BEST7003_RS15995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_RS16000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BEST7003_RS16010	COG0509	glycine decarboxylation via glycine cleavage system
BEST7003_RS16015	COG1393	Belongs to the ArsC family
BEST7003_RS16020	COG1960	acyl-CoA dehydrogenase activity
BEST7003_RS16025	COG0183	Belongs to the thiolase family
BEST7003_RS16030	COG1250	3-hydroxyacyl-CoA dehydrogenase
BEST7003_RS16030	COG1024	Enoyl-CoA hydratase
BEST7003_RS16035	COG0506	proline dehydrogenase activity
BEST7003_RS16045	COG5577	PFAM Coat F domain
BEST7003_RS16050	COG1846	Transcriptional regulator
BEST7003_RS16055	COG0477	Major facilitator Superfamily
BEST7003_RS16060	COG1942	4-Oxalocrotonate Tautomerase
BEST7003_RS16065	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS16070	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS16075	COG0583	DNA-binding transcription factor activity
BEST7003_RS16085	COG1120	ATPase activity
BEST7003_RS16105	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS16110	COG0783	Belongs to the Dps family
BEST7003_RS16115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7003_RS16120	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS16125	COG2770	Histidine kinase
BEST7003_RS16125	COG2205	protein histidine kinase activity
BEST7003_RS16130	COG1309	transcriptional regulator
BEST7003_RS16135	COG0114	fumarate hydratase activity
BEST7003_RS16145	COG0697	spore germination
BEST7003_RS16150	COG0814	amino acid
BEST7003_RS16160	COG2197	response regulator
BEST7003_RS16165	COG4585	Histidine kinase
BEST7003_RS16170	COG4758	membrane
BEST7003_RS16175	COG3595	metallopeptidase activity
BEST7003_RS16180	COG1842	Phage shock protein A
BEST7003_RS16185	COG4758	membrane
BEST7003_RS16190	COG2814	Major facilitator Superfamily
BEST7003_RS16195	COG2096	Adenosyltransferase
BEST7003_RS16200	COG1120	ATPase activity
BEST7003_RS16205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS16210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS16220	COG3386	PFAM SMP-30 Gluconolaconase
BEST7003_RS16225	COG2205	protein histidine kinase activity
BEST7003_RS16230	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS16240	COG1191	sigma factor activity
BEST7003_RS16245	COG2140	Oxalate decarboxylase
BEST7003_RS16255	COG0577	efflux transmembrane transporter activity
BEST7003_RS16260	COG1136	(ABC) transporter
BEST7003_RS16265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BEST7003_RS16270	COG1120	ATPase activity
BEST7003_RS16275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS16280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_RS16285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_RS16295	COG0531	amino acid
BEST7003_RS16305	COG1988	membrane-bound metal-dependent
BEST7003_RS16310	COG1368	sulfuric ester hydrolase activity
BEST7003_RS16315	COG1910	domain protein
BEST7003_RS16320	COG0725	ABC transporter, periplasmic molybdate-binding protein
BEST7003_RS16325	COG4149	molybdate abc transporter
BEST7003_RS16330	COG0656	L-ascorbic acid biosynthetic process
BEST7003_RS16340	COG0025	NhaP-type Na H and K H
BEST7003_RS16345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7003_RS16350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7003_RS16355	COG3973	AAA domain
BEST7003_RS16360	COG2860	membrane
BEST7003_RS16365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BEST7003_RS16370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BEST7003_RS16375	COG2217	Heavy metal translocating P-type atpase
BEST7003_RS16380	COG2217	Heavy metal translocating P-type atpase
BEST7003_RS16385	COG2608	mercury ion transmembrane transporter activity
BEST7003_RS16390	COG1937	Protein conserved in bacteria
BEST7003_RS16395	COG0673	inositol 2-dehydrogenase activity
BEST7003_RS16400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BEST7003_RS16405	COG1289	transmembrane transporter activity
BEST7003_RS16415	COG2076	Multidrug Resistance protein
BEST7003_RS16420	COG1309	transcriptional regulator
BEST7003_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS16430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BEST7003_RS16435	COG0557	exoribonuclease II activity
BEST7003_RS16440	COG1647	Serine aminopeptidase, S33
BEST7003_RS16445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BEST7003_RS16450	COG0596	Alpha beta hydrolase
BEST7003_RS16455	COG1476	TRANSCRIPTIONal
BEST7003_RS16460	COG1396	sequence-specific DNA binding
BEST7003_RS16465	COG1396	sequence-specific DNA binding
BEST7003_RS16470	COG1733	regulation of RNA biosynthetic process
BEST7003_RS16475	COG0840	transmembrane signaling receptor activity
BEST7003_RS16480	COG1174	glycine betaine transport
BEST7003_RS16485	COG1732	Glycine betaine
BEST7003_RS16490	COG1174	glycine betaine transport
BEST7003_RS16495	COG1125	glycine betaine transport
BEST7003_RS16495	COG0517	IMP dehydrogenase activity
BEST7003_RS16500	COG1510	regulation of RNA biosynthetic process
BEST7003_RS16520	COG5658	integral membrane protein
BEST7003_RS16525	COG0640	Transcriptional regulator
BEST7003_RS16530	COG1174	glycine betaine transport
BEST7003_RS16535	COG1732	Glycine betaine
BEST7003_RS16540	COG1174	glycine betaine transport
BEST7003_RS16545	COG1125	glycine betaine transport
BEST7003_RS16545	COG0517	IMP dehydrogenase activity
BEST7003_RS16550	COG1510	regulation of RNA biosynthetic process
BEST7003_RS16555	COG2095	MarC family integral membrane protein
BEST7003_RS16565	COG3064	Membrane
BEST7003_RS16570	COG4640	response to antibiotic
BEST7003_RS16575	COG0456	acetyltransferase
BEST7003_RS16580	COG0148	phosphopyruvate hydratase activity
BEST7003_RS16585	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BEST7003_RS16590	COG0149	triose-phosphate isomerase activity
BEST7003_RS16595	COG0126	phosphoglycerate kinase activity
BEST7003_RS16600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BEST7003_RS16605	COG2390	Transcriptional regulator
BEST7003_RS16610	COG2814	Major facilitator Superfamily
BEST7003_RS16615	COG1609	Transcriptional regulator
BEST7003_RS16620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_RS16625	COG0583	DNA-binding transcription factor activity
BEST7003_RS16630	COG0697	spore germination
BEST7003_RS16635	COG1113	amino acid transport
BEST7003_RS16640	COG3858	chitin binding
BEST7003_RS16645	COG1556	Lactate utilization protein
BEST7003_RS16650	COG1139	Iron-sulfur cluster binding protein
BEST7003_RS16655	COG0247	lactate metabolic process
BEST7003_RS16660	COG2197	response regulator
BEST7003_RS16665	COG4585	Histidine kinase
BEST7003_RS16670	COG0842	Transport permease protein
BEST7003_RS16675	COG1131	(ABC) transporter
BEST7003_RS16680	COG0596	Alpha beta hydrolase
BEST7003_RS16685	COG2208	phosphoserine phosphatase activity
BEST7003_RS16690	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BEST7003_RS16695	COG1874	Beta-galactosidase
BEST7003_RS16700	COG3833	ABC-type maltose transport systems, permease component
BEST7003_RS16705	COG1175	transmembrane transport
BEST7003_RS16710	COG2182	Extracellular solute-binding protein
BEST7003_RS16715	COG1609	Transcriptional regulator
BEST7003_RS16720	COG2186	Transcriptional regulator
BEST7003_RS16725	COG1620	l-lactate permease
BEST7003_RS16730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BEST7003_RS16740	COG5039	Polysaccharide pyruvyl transferase
BEST7003_RS16745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7003_RS16750	COG0110	maltose O-acetyltransferase activity
BEST7003_RS16755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BEST7003_RS16780	COG1215	transferase activity, transferring glycosyl groups
BEST7003_RS16785	COG0438	transferase activity, transferring glycosyl groups
BEST7003_RS16790	COG1086	Polysaccharide biosynthesis protein
BEST7003_RS16795	COG0489	protein tyrosine kinase activity
BEST7003_RS16800	COG3944	biosynthesis protein
BEST7003_RS16805	COG1396	sequence-specific DNA binding
BEST7003_RS16810	COG2272	Belongs to the type-B carboxylesterase lipase family
BEST7003_RS16820	COG3479	Phenolic acid decarboxylase
BEST7003_RS16830	COG1794	racemase activity, acting on amino acids and derivatives
BEST7003_RS16835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BEST7003_RS16840	COG1621	beta-fructofuranosidase activity
BEST7003_RS16845	COG1621	beta-fructofuranosidase activity
BEST7003_RS16850	COG0531	amino acid
BEST7003_RS16855	COG1309	transcriptional regulator
BEST7003_RS16860	COG2076	Multidrug Resistance protein
BEST7003_RS16865	COG2076	Multidrug Resistance protein
BEST7003_RS16875	COG0277	FAD linked oxidase domain protein
BEST7003_RS16880	COG3621	Patatin-like phospholipase
BEST7003_RS16890	COG0740	serine-type endopeptidase activity
BEST7003_RS16895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BEST7003_RS16900	COG0366	Alpha amylase catalytic
BEST7003_RS16905	COG1554	hydrolase, family 65, central catalytic
BEST7003_RS16910	COG5521	maltodextrose utilization protein MalA
BEST7003_RS16915	COG3833	ABC-type maltose transport systems, permease component
BEST7003_RS16920	COG1175	transmembrane transport
BEST7003_RS16925	COG2182	Extracellular solute-binding protein
BEST7003_RS16930	COG0366	Alpha amylase catalytic
BEST7003_RS16935	COG1609	Transcriptional regulator
BEST7003_RS16940	COG1611	Belongs to the LOG family
BEST7003_RS16945	COG1694	Mazg nucleotide pyrophosphohydrolase
BEST7003_RS16950	COG0659	secondary active sulfate transmembrane transporter activity
BEST7003_RS16955	COG0288	reversible hydration of carbon dioxide
BEST7003_RS16960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BEST7003_RS16965	COG0577	efflux transmembrane transporter activity
BEST7003_RS16970	COG1136	(ABC) transporter
BEST7003_RS16975	COG5002	protein histidine kinase activity
BEST7003_RS16980	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS16990	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BEST7003_RS16995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_RS17000	COG1481	regulation of sporulation
BEST7003_RS17005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BEST7003_RS17010	COG1660	Displays ATPase and GTPase activities
BEST7003_RS17015	COG1051	belongs to the nudix hydrolase family
BEST7003_RS17020	COG0492	ferredoxin-NADP+ reductase activity
BEST7003_RS17025	COG0791	NLP P60 protein
BEST7003_RS17025	COG3883	PFAM NLP P60 protein
BEST7003_RS17030	COG0457	Tetratricopeptide repeat
BEST7003_RS17035	COG1132	(ABC) transporter
BEST7003_RS17055	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BEST7003_RS17055	COG0140	phosphoribosyl-ATP diphosphatase activity
BEST7003_RS17060	COG0107	imidazoleglycerol-phosphate synthase activity
BEST7003_RS17065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BEST7003_RS17070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BEST7003_RS17075	COG0131	Imidazoleglycerol-phosphate dehydratase
BEST7003_RS17080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BEST7003_RS17085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BEST7003_RS17090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BEST7003_RS17095	COG4990	cell redox homeostasis
BEST7003_RS17100	COG5297	Belongs to the glycosyl hydrolase family 6
BEST7003_RS17105	COG0110	maltose O-acetyltransferase activity
BEST7003_RS17110	COG0546	phosphoglycolate phosphatase activity
BEST7003_RS17115	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BEST7003_RS17120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BEST7003_RS17125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BEST7003_RS17130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BEST7003_RS17135	COG0363	glucosamine-6-phosphate deaminase activity
BEST7003_RS17140	COG2188	Transcriptional regulator
BEST7003_RS17145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BEST7003_RS17150	COG1846	Transcriptional regulator
BEST7003_RS17155	COG2124	cytochrome p450
BEST7003_RS17165	COG1846	Transcriptional regulator
BEST7003_RS17170	COG2814	Major facilitator Superfamily
BEST7003_RS17175	COG1950	PFAM Membrane protein of
BEST7003_RS17180	COG1983	PspC domain protein
BEST7003_RS17185	COG3595	metallopeptidase activity
BEST7003_RS17200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BEST7003_RS17205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BEST7003_RS17210	COG0556	nucleotide-excision repair
BEST7003_RS17215	COG4897	Protein conserved in bacteria
BEST7003_RS17220	COG0574	Belongs to the PEP-utilizing enzyme family
BEST7003_RS17220	COG3848	Pyruvate phosphate dikinase
BEST7003_RS17225	COG1309	transcriptional regulator
BEST7003_RS17230	COG2814	Major facilitator Superfamily
BEST7003_RS17235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7003_RS17245	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_RS17245	COG0793	Belongs to the peptidase S41A family
BEST7003_RS17250	COG2177	Part of the ABC transporter FtsEX involved in
BEST7003_RS17255	COG2884	Cell division ATP-binding protein ftsE
BEST7003_RS17260	COG2010	Cytochrome c
BEST7003_RS17265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_RS17270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BEST7003_RS17275	COG0653	protein targeting
BEST7003_RS17280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BEST7003_RS17295	COG1516	flagellar protein fliS
BEST7003_RS17300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BEST7003_RS17305	COG1334	flagellar protein FlaG
BEST7003_RS17310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BEST7003_RS17315	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BEST7003_RS17320	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BEST7003_RS17330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BEST7003_RS17335	COG1256	bacterial-type flagellum assembly
BEST7003_RS17335	COG4786	Flagellar basal body rod
BEST7003_RS17340	COG3418	PFAM FlgN family protein
BEST7003_RS17345	COG2747	anti-sigma28 factor FlgM
BEST7003_RS17355	COG1040	competence protein
BEST7003_RS17365	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BEST7003_RS17370	COG1307	EDD domain protein, DegV family
BEST7003_RS17375	COG2197	response regulator
BEST7003_RS17380	COG4585	Histidine kinase
BEST7003_RS17385	COG1739	Uncharacterized protein family UPF0029
BEST7003_RS17390	COG1316	TRANSCRIPTIONal
BEST7003_RS17395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BEST7003_RS17400	COG0438	transferase activity, transferring glycosyl groups
BEST7003_RS17405	COG1215	transferase activity, transferring glycosyl groups
BEST7003_RS17410	COG3206	protein involved in exopolysaccharide biosynthesis
BEST7003_RS17415	COG3307	-O-antigen
BEST7003_RS17420	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7003_RS17425	COG0297	glycogen (starch) synthase activity
BEST7003_RS17425	COG0438	transferase activity, transferring glycosyl groups
BEST7003_RS17430	COG2244	polysaccharide biosynthetic process
BEST7003_RS17440	COG2247	cell wall binding repeat
BEST7003_RS17440	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_RS17445	COG2385	sporulation resulting in formation of a cellular spore
BEST7003_RS17445	COG2247	cell wall binding repeat
BEST7003_RS17455	COG1316	TRANSCRIPTIONal
BEST7003_RS17460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BEST7003_RS17465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7003_RS17470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7003_RS17470	COG1215	transferase activity, transferring glycosyl groups
BEST7003_RS17475	COG0463	Glycosyl transferase, family 2
BEST7003_RS17485	COG1134	teichoic acid transport
BEST7003_RS17490	COG1682	transport, permease protein
BEST7003_RS17495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7003_RS17500	COG0438	transferase activity, transferring glycosyl groups
BEST7003_RS17505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BEST7003_RS17510	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BEST7003_RS17515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7003_RS17525	COG4193	domain, Protein
BEST7003_RS17530	COG1482	cell wall glycoprotein biosynthetic process
BEST7003_RS17535	COG0697	spore germination
BEST7003_RS17540	COG0814	amino acid
BEST7003_RS17550	COG2814	Major facilitator Superfamily
BEST7003_RS17555	COG1316	TRANSCRIPTIONal
BEST7003_RS17560	COG0561	phosphatase activity
BEST7003_RS17565	COG0791	NLP P60 protein
BEST7003_RS17570	COG2843	Capsule synthesis protein
BEST7003_RS17580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BEST7003_RS17585	COG1609	Transcriptional regulator
BEST7003_RS17590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_RS17595	COG1869	D-ribose catabolic process
BEST7003_RS17600	COG1129	ABC transporter
BEST7003_RS17605	COG1172	Belongs to the binding-protein-dependent transport system permease family
BEST7003_RS17610	COG1879	ABC-type sugar transport system periplasmic component
BEST7003_RS17615	COG3103	Sh3 type 3 domain protein
BEST7003_RS17625	COG2249	NAD(P)H dehydrogenase (quinone) activity
BEST7003_RS17630	COG3527	Alpha-acetolactate decarboxylase
BEST7003_RS17635	COG0028	Belongs to the TPP enzyme family
BEST7003_RS17640	COG0583	DNA-binding transcription factor activity
BEST7003_RS17645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BEST7003_RS17660	COG5337	Spore coat protein CotH
BEST7003_RS17670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7003_RS17680	COG0405	Gamma-glutamyltransferase
BEST7003_RS17685	COG1522	sequence-specific DNA binding
BEST7003_RS17690	COG2059	Chromate
BEST7003_RS17695	COG2059	Chromate
BEST7003_RS17705	COG0655	NAD(P)H dehydrogenase (quinone) activity
BEST7003_RS17710	COG0583	DNA-binding transcription factor activity
BEST7003_RS17715	COG1515	deoxyribonuclease V activity
BEST7003_RS17720	COG2849	repeat protein
BEST7003_RS17725	COG5444	nuclease activity
BEST7003_RS17740	COG3878	Protein conserved in bacteria
BEST7003_RS17745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7003_RS17750	COG4464	protein tyrosine phosphatase activity
BEST7003_RS17755	COG0489	protein tyrosine kinase activity
BEST7003_RS17760	COG3944	biosynthesis protein
BEST7003_RS17765	COG4715	Zinc finger, swim domain protein
BEST7003_RS17770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BEST7003_RS17775	COG0561	phosphatase activity
BEST7003_RS17780	COG1349	DNA-binding transcription factor activity
BEST7003_RS17785	COG0629	single-stranded DNA binding
BEST7003_RS17800	COG3764	Sortase (surface protein transpeptidase)
BEST7003_RS17805	COG2972	Histidine kinase
BEST7003_RS17805	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS17810	COG1970	mechanosensitive ion channel activity
BEST7003_RS17815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BEST7003_RS17820	COG0457	Tetratricopeptide repeat
BEST7003_RS17825	COG4786	Flagellar basal body rod
BEST7003_RS17830	COG4786	Flagellar basal body rod
BEST7003_RS17835	COG1077	Cell shape determining protein MreB Mrl
BEST7003_RS17840	COG1609	Transcriptional regulator
BEST7003_RS17845	COG1846	Transcriptional regulator
BEST7003_RS17850	COG2814	Major facilitator Superfamily
BEST7003_RS17855	COG3420	alginic acid biosynthetic process
BEST7003_RS17860	COG1953	Uracil, thiamine, allantoin
BEST7003_RS17865	COG0477	Major facilitator Superfamily
BEST7003_RS17870	COG1335	isochorismatase
BEST7003_RS17880	COG0004	ammonium transporteR
BEST7003_RS17885	COG0347	Belongs to the P(II) protein family
BEST7003_RS17890	COG0671	phosphoesterase, PA-phosphatase related
BEST7003_RS17900	COG0739	heme binding
BEST7003_RS17905	COG1247	-acetyltransferase
BEST7003_RS17920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BEST7003_RS17925	COG0789	Transcriptional regulator
BEST7003_RS17935	COG2910	NAD(P)H-binding
BEST7003_RS17940	COG1959	2 iron, 2 sulfur cluster binding
BEST7003_RS17945	COG0804	urea catabolic process
BEST7003_RS17950	COG0832	Belongs to the urease beta subunit family
BEST7003_RS17955	COG0831	urea catabolic process
BEST7003_RS17965	COG3237	CsbD-like
BEST7003_RS17970	COG1994	Peptidase M50
BEST7003_RS17975	COG0457	Tetratricopeptide repeat
BEST7003_RS17980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BEST7003_RS17985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BEST7003_RS17990	COG2304	oxidoreductase activity
BEST7003_RS18000	COG2304	oxidoreductase activity
BEST7003_RS18005	COG2385	sporulation resulting in formation of a cellular spore
BEST7003_RS18010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BEST7003_RS18020	COG4836	Membrane
BEST7003_RS18030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BEST7003_RS18035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BEST7003_RS18040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BEST7003_RS18045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BEST7003_RS18050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BEST7003_RS18055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BEST7003_RS18065	COG0356	it plays a direct role in the translocation of protons across the membrane
BEST7003_RS18075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BEST7003_RS18080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BEST7003_RS18085	COG4475	Protein of unknown function (DUF436)
BEST7003_RS18090	COG0698	ribose 5-phosphate isomerase
BEST7003_RS18095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7003_RS18100	COG1971	Probably functions as a manganese efflux pump
BEST7003_RS18105	COG0009	L-threonylcarbamoyladenylate synthase
BEST7003_RS18110	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BEST7003_RS18130	COG2890	protein-(glutamine-N5) methyltransferase activity
BEST7003_RS18135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BEST7003_RS18140	COG0346	lactoylglutathione lyase activity
BEST7003_RS18145	COG0789	Transcriptional regulator
BEST7003_RS18150	COG0679	Auxin Efflux Carrier
BEST7003_RS18155	COG0281	malic enzyme
BEST7003_RS18160	COG1435	thymidine kinase activity
BEST7003_RS18170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BEST7003_RS18175	COG1494	fructose-1,6-bisphosphatase
BEST7003_RS18180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BEST7003_RS18185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BEST7003_RS18190	COG0191	fructose-bisphosphate aldolase activity
BEST7003_RS18195	COG2204	response regulator
BEST7003_RS18200	COG4821	SIS domain
BEST7003_RS18205	COG0504	CTP synthase activity
BEST7003_RS18210	COG3343	RNA polymerase activity
BEST7003_RS18215	COG1960	acyl-CoA dehydrogenase activity
BEST7003_RS18220	COG2181	nitrate reductase activity
BEST7003_RS18220	COG0247	lactate metabolic process
BEST7003_RS18225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BEST7003_RS18230	COG4294	response to UV
BEST7003_RS18240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BEST7003_RS18245	COG1132	(ABC) transporter
BEST7003_RS18250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BEST7003_RS18255	COG2181	nitrate reductase activity
BEST7003_RS18260	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BEST7003_RS18265	COG1140	nitrate reductase beta subunit
BEST7003_RS18270	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BEST7003_RS18275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7003_RS18285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7003_RS18290	COG2223	nitrite transmembrane transporter activity
BEST7003_RS18295	COG0018	arginyl-trna synthetase
BEST7003_RS18300	COG4506	Protein conserved in bacteria
BEST7003_RS18310	COG0535	radical SAM domain protein
BEST7003_RS18320	COG1131	(ABC) transporter
BEST7003_RS18325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7003_RS18330	COG0612	Peptidase, M16
BEST7003_RS18335	COG0612	Peptidase, M16
BEST7003_RS18345	COG3391	amine dehydrogenase activity
BEST7003_RS18350	COG3391	amine dehydrogenase activity
BEST7003_RS18360	COG0457	Tetratricopeptide repeat
BEST7003_RS18370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BEST7003_RS18375	COG0010	Belongs to the arginase family
BEST7003_RS18380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BEST7003_RS18385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7003_RS18395	COG1994	Peptidase M50
BEST7003_RS18400	COG1942	4-Oxalocrotonate Tautomerase
BEST7003_RS18405	COG1846	Transcriptional regulator
BEST7003_RS18410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BEST7003_RS18415	COG0477	Major facilitator Superfamily
BEST7003_RS18420	COG1959	2 iron, 2 sulfur cluster binding
BEST7003_RS18425	COG3465	dGTPase activity
BEST7003_RS18430	COG1078	dGTPase activity
BEST7003_RS18435	COG4844	belongs to the
BEST7003_RS18445	COG0697	spore germination
BEST7003_RS18450	COG0095	Lipoate-protein ligase
BEST7003_RS18455	COG0583	DNA-binding transcription factor activity
BEST7003_RS18460	COG0280	phosphate acetyltransferase
BEST7003_RS18465	COG3253	May function as heme-dependent peroxidase
BEST7003_RS18470	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS18475	COG0436	Aminotransferase
BEST7003_RS18480	COG2814	Major facilitator Superfamily
BEST7003_RS18485	COG0151	Belongs to the GarS family
BEST7003_RS18490	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS18495	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_RS18500	COG0077	Prephenate dehydratase
BEST7003_RS18505	COG2814	Major facilitator Superfamily
BEST7003_RS18510	COG0833	amino acid
BEST7003_RS18515	COG4187	Peptidase family M20/M25/M40
BEST7003_RS18520	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS18525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7003_RS18535	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BEST7003_RS18540	COG1091	dTDP-4-dehydrorhamnose reductase activity
BEST7003_RS18545	COG1088	dTDP-glucose 4,6-dehydratase activity
BEST7003_RS18550	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BEST7003_RS18555	COG3980	spore coat polysaccharide biosynthesis protein
BEST7003_RS18560	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BEST7003_RS18565	COG2089	acid synthase
BEST7003_RS18570	COG0456	acetyltransferase
BEST7003_RS18575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7003_RS18580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7003_RS18585	COG0463	Glycosyl transferase, family 2
BEST7003_RS18600	COG2363	Small membrane protein
BEST7003_RS18605	COG2233	PERMEase
BEST7003_RS18615	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS18620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BEST7003_RS18625	COG1216	Glycosyl transferase, family 2
BEST7003_RS18640	COG1695	Transcriptional regulator
BEST7003_RS18645	COG0351	phosphomethylpyrimidine kinase
BEST7003_RS18655	COG1621	beta-fructofuranosidase activity
BEST7003_RS18660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS18660	COG1263	PTS System
BEST7003_RS18665	COG2116	formate transmembrane transporter activity
BEST7003_RS18670	COG3711	transcriptional antiterminator
BEST7003_RS18680	COG1404	Belongs to the peptidase S8 family
BEST7003_RS18685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_RS18690	COG0778	Nitroreductase
BEST7003_RS18695	COG0772	Belongs to the SEDS family
BEST7003_RS18705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BEST7003_RS18710	COG1845	cytochrome c oxidase, subunit III
BEST7003_RS18715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BEST7003_RS18720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BEST7003_RS18725	COG2261	transglycosylase associated protein
BEST7003_RS18730	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BEST7003_RS18735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BEST7003_RS18740	COG2246	polysaccharide biosynthetic process
BEST7003_RS18745	COG1309	transcriptional regulator
BEST7003_RS18755	COG3162	membrane
BEST7003_RS18760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_RS18765	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BEST7003_RS18770	COG2837	iron assimilation
BEST7003_RS18775	COG2822	iron ion transport
BEST7003_RS18780	COG0672	)-iron permease
BEST7003_RS18785	COG0352	thiamine-phosphate diphosphorylase activity
BEST7003_RS18790	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BEST7003_RS18795	COG0583	DNA-binding transcription factor activity
BEST7003_RS18800	COG1380	Effector of murein hydrolase LrgA
BEST7003_RS18805	COG1346	cytolysis
BEST7003_RS18810	COG2814	Major facilitator Superfamily
BEST7003_RS18815	COG4895	conserved protein (DUF2196)
BEST7003_RS18820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BEST7003_RS18825	COG0346	lactoylglutathione lyase activity
BEST7003_RS18835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_RS18840	COG1404	Belongs to the peptidase S8 family
BEST7003_RS18845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS18845	COG1263	PTS System
BEST7003_RS18850	COG3711	transcriptional antiterminator
BEST7003_RS18855	COG1442	glycosyl transferase family 8
BEST7003_RS18860	COG5522	Integral membrane protein (intg_mem_TP0381)
BEST7003_RS18865	COG1846	Transcriptional regulator
BEST7003_RS18870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BEST7003_RS18875	COG2234	aminopeptidase activity
BEST7003_RS18880	COG2357	RelA SpoT domain protein
BEST7003_RS18885	COG1575	Belongs to the MenA family. Type 1 subfamily
BEST7003_RS18895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_RS18900	COG1696	Membrane protein involved in D-alanine export
BEST7003_RS18905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_RS18910	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BEST7003_RS18915	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BEST7003_RS18920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7003_RS18925	COG1486	melibiose metabolic process
BEST7003_RS18930	COG1447	Phosphotransferase system cellobiose-specific component IIA
BEST7003_RS18935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_RS18940	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_RS18945	COG3711	transcriptional antiterminator
BEST7003_RS18945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_RS18950	COG2094	Belongs to the DNA glycosylase MPG family
BEST7003_RS18955	COG0753	catalase activity
BEST7003_RS18960	COG2814	Major facilitator Superfamily
BEST7003_RS18965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BEST7003_RS18970	COG1131	(ABC) transporter
BEST7003_RS18990	COG1595	DNA-templated transcription, initiation
BEST7003_RS18995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BEST7003_RS19000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BEST7003_RS19005	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BEST7003_RS19010	COG4988	ABC transporter
BEST7003_RS19015	COG1294	oxidase, subunit
BEST7003_RS19020	COG1271	oxidase subunit
BEST7003_RS19025	COG3493	citrate carrier protein
BEST7003_RS19030	COG0501	Belongs to the peptidase M48B family
BEST7003_RS19040	COG0726	polysaccharide deacetylase
BEST7003_RS19045	COG3842	ATPase activity
BEST7003_RS19050	COG2508	Transcriptional regulator
BEST7003_RS19055	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS19060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_RS19070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BEST7003_RS19075	COG1881	PFAM PEBP family protein
BEST7003_RS19080	COG0583	DNA-binding transcription factor activity
BEST7003_RS19090	COG4585	Histidine kinase
BEST7003_RS19095	COG2197	response regulator
BEST7003_RS19100	COG2195	Cleaves the N-terminal amino acid of tripeptides
BEST7003_RS19105	COG4894	glucomannan catabolic process
BEST7003_RS19110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BEST7003_RS19115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BEST7003_RS19120	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS19125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BEST7003_RS19130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BEST7003_RS19135	COG2610	gluconate transmembrane transporter activity
BEST7003_RS19140	COG0500	methyltransferase
BEST7003_RS19145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BEST7003_RS19165	COG0693	protein deglycase activity
BEST7003_RS19165	COG0753	catalase activity
BEST7003_RS19170	COG2851	Citrate transporter
BEST7003_RS19175	COG2273	Hydrolase Family 16
BEST7003_RS19180	COG3711	transcriptional antiterminator
BEST7003_RS19190	COG2270	Major facilitator Superfamily
BEST7003_RS19195	COG0513	Belongs to the DEAD box helicase family
BEST7003_RS19200	COG2755	lipolytic protein G-D-S-L family
BEST7003_RS19200	COG3401	FG-GAP repeat protein
BEST7003_RS19250	COG3209	COG3209 Rhs family protein
BEST7003_RS19255	COG0697	spore germination
BEST7003_RS19260	COG0589	response to stress
BEST7003_RS19265	COG2723	6-phospho-beta-galactosidase activity
BEST7003_RS19270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_RS19270	COG2190	(PTS) system
BEST7003_RS19270	COG1263	PTS System
BEST7003_RS19285	COG5444	nuclease activity
BEST7003_RS19300	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7003_RS19310	COG2986	histidine ammonia-lyase
BEST7003_RS19315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BEST7003_RS19320	COG1228	amidohydrolase
BEST7003_RS19325	COG0010	Belongs to the arginase family
BEST7003_RS19330	COG0833	amino acid
BEST7003_RS19335	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BEST7003_RS19340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BEST7003_RS19345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BEST7003_RS19350	COG2390	Transcriptional regulator
BEST7003_RS19360	COG3192	ethanolamine utilization protein
BEST7003_RS19365	COG2079	MmgE PrpD family protein
BEST7003_RS19370	COG1473	amidohydrolase
BEST7003_RS19375	COG1126	abc transporter atp-binding protein
BEST7003_RS19380	COG0765	amino acid transport
BEST7003_RS19385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_RS19390	COG0456	acetyltransferase
BEST7003_RS19395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_RS19405	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BEST7003_RS19410	COG0561	phosphatase activity
BEST7003_RS19440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_RS19445	COG5294	Protein conserved in bacteria
BEST7003_RS19450	COG0577	efflux transmembrane transporter activity
BEST7003_RS19455	COG1136	(ABC) transporter
BEST7003_RS19460	COG2205	protein histidine kinase activity
BEST7003_RS19465	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS19470	COG0191	fructose-bisphosphate aldolase activity
BEST7003_RS19475	COG1082	Xylose isomerase domain protein TIM barrel
BEST7003_RS19480	COG1082	Xylose isomerase domain protein TIM barrel
BEST7003_RS19485	COG0673	inositol 2-dehydrogenase activity
BEST7003_RS19490	COG2814	Major facilitator Superfamily
BEST7003_RS19495	COG1082	Xylose isomerase domain protein TIM barrel
BEST7003_RS19500	COG3962	Belongs to the TPP enzyme family
BEST7003_RS19505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_RS19510	COG3718	enzyme involved in inositol metabolism
BEST7003_RS19515	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS19520	COG1349	DNA-binding transcription factor activity
BEST7003_RS19525	COG0667	Aldo Keto reductase
BEST7003_RS19540	COG2814	Major facilitator Superfamily
BEST7003_RS19545	COG0326	Molecular chaperone. Has ATPase activity
BEST7003_RS19555	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS19560	COG1309	transcriptional regulator
BEST7003_RS19565	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_RS19570	COG0456	acetyltransferase
BEST7003_RS19575	COG2850	peptidyl-arginine hydroxylation
BEST7003_RS19580	COG2226	methyltransferase
BEST7003_RS19595	COG0367	asparagine synthase
BEST7003_RS19600	COG2814	Major facilitator Superfamily
BEST7003_RS19605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BEST7003_RS19615	COG1714	RDD family
BEST7003_RS19620	COG2311	Membrane
BEST7003_RS19625	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_RS19630	COG1309	transcriptional regulator
BEST7003_RS19635	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_RS19640	COG1846	Transcriptional regulator
BEST7003_RS19645	COG1380	Effector of murein hydrolase LrgA
BEST7003_RS19650	COG1346	cytolysis
BEST7003_RS19655	COG5039	Polysaccharide pyruvyl transferase
BEST7003_RS19660	COG1929	Belongs to the glycerate kinase type-1 family
BEST7003_RS19665	COG1802	Transcriptional regulator
BEST7003_RS19670	COG1070	Carbohydrate kinase
BEST7003_RS19680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BEST7003_RS19685	COG0450	alkyl hydroperoxide reductase
BEST7003_RS19690	COG3634	alkyl hydroperoxide reductase activity
BEST7003_RS19695	COG2723	6-phospho-beta-galactosidase activity
BEST7003_RS19700	COG2190	(PTS) system
BEST7003_RS19705	COG2188	Transcriptional regulator
BEST7003_RS19720	COG1131	(ABC) transporter
BEST7003_RS19725	COG1994	Peptidase M50
BEST7003_RS19730	COG0535	radical SAM domain protein
BEST7003_RS19740	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BEST7003_RS19745	COG5293	efflux transmembrane transporter activity
BEST7003_RS19755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BEST7003_RS19760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BEST7003_RS19770	COG1063	alcohol dehydrogenase
BEST7003_RS19790	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
BEST7003_RS19795	COG0456	acetyltransferase
BEST7003_RS19800	COG0457	Tetratricopeptide repeat
BEST7003_RS19810	COG0010	Belongs to the arginase family
BEST7003_RS19815	COG0833	amino acid
BEST7003_RS19820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BEST7003_RS19825	COG3829	transcription factor binding
BEST7003_RS19830	COG5002	protein histidine kinase activity
BEST7003_RS19835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7003_RS19840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BEST7003_RS19845	COG4853	Protein conserved in bacteria
BEST7003_RS19850	COG4863	YycH protein
BEST7003_RS19855	COG5002	protein histidine kinase activity
BEST7003_RS19860	COG0745	RESPONSE REGULATOR receiver
BEST7003_RS19890	COG0346	lactoylglutathione lyase activity
BEST7003_RS19895	COG0305	Participates in initiation and elongation during chromosome replication
BEST7003_RS19910	COG2807	transmembrane transport
BEST7003_RS19915	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BEST7003_RS19920	COG0359	binds to the 23S rRNA
BEST7003_RS19925	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BEST7003_RS19930	COG4241	membrane
BEST7003_RS19940	COG5577	PFAM Coat F domain
BEST7003_RS19945	COG1733	regulation of RNA biosynthetic process
BEST7003_RS19950	COG1227	inorganic diphosphatase activity
BEST7003_RS19965	COG2271	Major facilitator Superfamily
BEST7003_RS20000	COG1131	(ABC) transporter
BEST7003_RS20010	COG4319	ketosteroid isomerase
BEST7003_RS20015	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7003_RS20020	COG2814	Major facilitator Superfamily
BEST7003_RS20025	COG0583	DNA-binding transcription factor activity
BEST7003_RS20030	COG2153	protein acetylation
BEST7003_RS20040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_RS20045	COG1846	Transcriptional regulator
BEST7003_RS20050	COG2153	protein acetylation
BEST7003_RS20055	COG2364	Membrane
BEST7003_RS20060	COG0456	acetyltransferase
BEST7003_RS20065	COG2315	Protein conserved in bacteria
BEST7003_RS20070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BEST7003_RS20075	COG2814	Major facilitator Superfamily
BEST7003_RS20080	COG1331	Highly conserved protein containing a thioredoxin domain
BEST7003_RS20085	COG0789	Transcriptional regulator
BEST7003_RS20090	COG0697	spore germination
BEST7003_RS20095	COG1331	Highly conserved protein containing a thioredoxin domain
BEST7003_RS20100	COG1266	CAAX protease self-immunity
BEST7003_RS20105	COG2814	Major facilitator Superfamily
BEST7003_RS20105	COG0477	Major facilitator Superfamily
BEST7003_RS20110	COG0110	maltose O-acetyltransferase activity
BEST7003_RS20115	COG0346	lactoylglutathione lyase activity
BEST7003_RS20120	COG1609	Transcriptional regulator
BEST7003_RS20125	COG0708	Exodeoxyribonuclease III
BEST7003_RS20130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BEST7003_RS20135	COG0629	single-stranded DNA binding
BEST7003_RS20140	COG0360	Binds together with S18 to 16S ribosomal RNA
BEST7003_RS20145	COG0012	GTP binding
BEST7003_RS20150	COG0243	molybdopterin cofactor binding
BEST7003_RS20155	COG4481	Protein conserved in bacteria
BEST7003_RS20160	COG3949	Membrane
BEST7003_RS20170	COG1475	DNA binding
BEST7003_RS20175	COG1192	Involved in chromosome partitioning
BEST7003_RS20185	COG1475	DNA binding
BEST7003_RS20190	COG0357	Ribosomal RNA small subunit methyltransferase G
BEST7003_RS20195	COG0445	tRNA wobble uridine modification
BEST7003_RS20200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BEST7003_RS20205	COG1847	R3H domain protein
BEST7003_RS20210	COG0706	membrane insertase activity
BEST7003_RS20215	COG0594	ribonuclease P activity