locus-tag	class	description
JR441_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JR441_RS00010	COG0592	DNA-directed DNA polymerase activity
JR441_RS00015	COG2501	S4 domain
JR441_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JR441_RS00030	COG0187	DNA topoisomerase II activity
JR441_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JR441_RS00070	COG0516	GMP reductase activity
JR441_RS00070	COG0517	IMP dehydrogenase activity
JR441_RS00075	COG1686	Belongs to the peptidase S11 family
JR441_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JR441_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JR441_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JR441_RS00100	COG1428	Deoxynucleoside kinase
JR441_RS00105	COG1428	Deoxynucleoside kinase
JR441_RS00110	COG3858	chitin binding
JR441_RS00110	COG1388	LysM domain
JR441_RS00115	COG1335	isochorismatase
JR441_RS00120	COG0590	tRNA wobble adenosine to inosine editing
JR441_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JR441_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JR441_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JR441_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
JR441_RS00190	COG3853	Toxic anion resistance protein (TelA)
JR441_RS00195	COG1982	Orn Lys Arg decarboxylase major
JR441_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JR441_RS00205	COG3870	Protein conserved in bacteria
JR441_RS00210	COG1728	Protein conserved in bacteria
JR441_RS00215	COG0470	DNA polymerase III
JR441_RS00220	COG1774	PSP1 C-terminal conserved region
JR441_RS00225	COG4467	Involved in initiation control of chromosome replication
JR441_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JR441_RS00235	COG2827	Endonuclease containing a URI domain
JR441_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JR441_RS00245	COG2002	toxin-antitoxin pair type II binding
JR441_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_RS00255	COG0084	hydrolase, TatD family'
JR441_RS00260	COG3584	3D domain protein
JR441_RS00260	COG3583	domain protein
JR441_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JR441_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JR441_RS00280	COG4466	Protein conserved in bacteria
JR441_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JR441_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JR441_RS00300	COG0251	oxidation-reduction process
JR441_RS00305	COG2088	sporulation resulting in formation of a cellular spore
JR441_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JR441_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JR441_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JR441_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
JR441_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JR441_RS00340	COG2002	toxin-antitoxin pair type II binding
JR441_RS00345	COG2244	polysaccharide biosynthetic process
JR441_RS00350	COG3956	TIGRFAM MazG family protein
JR441_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JR441_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JR441_RS00375	COG1098	S1 RNA binding domain
JR441_RS00390	COG2208	phosphoserine phosphatase activity
JR441_RS00395	COG2304	oxidoreductase activity
JR441_RS00400	COG0515	serine threonine protein kinase
JR441_RS00405	COG0037	tRNA processing
JR441_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JR441_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JR441_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JR441_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JR441_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JR441_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JR441_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JR441_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
JR441_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JR441_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JR441_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JR441_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JR441_RS00470	COG1396	sequence-specific DNA binding
JR441_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JR441_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JR441_RS00560	COG4463	regulation of RNA biosynthetic process
JR441_RS00565	COG3880	PFAM UvrB UvrC protein
JR441_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JR441_RS00575	COG0542	response to heat
JR441_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JR441_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JR441_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
JR441_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JR441_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JR441_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JR441_RS00610	COG1045	serine acetyltransferase
JR441_RS00615	COG0215	cysteine-tRNA ligase activity
JR441_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JR441_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JR441_RS00630	COG3688	RNA-binding protein containing a PIN domain
JR441_RS00635	COG1595	DNA-templated transcription, initiation
JR441_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JR441_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
JR441_RS00660	COG0081	regulation of translation
JR441_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JR441_RS00675	COG2813	Specifically methylates the guanine in position
JR441_RS00680	COG0085	RNA polymerase activity
JR441_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JR441_RS00690	COG1358	cellular component organization or biogenesis
JR441_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JR441_RS00700	COG0049	tRNA binding
JR441_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JR441_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JR441_RS00715	COG0596	Alpha beta hydrolase
JR441_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JR441_RS00730	COG0088	Forms part of the polypeptide exit tunnel
JR441_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JR441_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JR441_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JR441_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JR441_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JR441_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JR441_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JR441_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JR441_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JR441_RS00820	COG0200	Binds to the 23S rRNA
JR441_RS00825	COG0201	protein transport
JR441_RS00830	COG0563	adenylate kinase activity
JR441_RS00835	COG0024	Methionine aminopeptidase
JR441_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JR441_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JR441_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JR441_RS00865	COG0202	RNA polymerase activity
JR441_RS00870	COG0203	ribosomal protein L17
JR441_RS00875	COG1122	ATPase activity
JR441_RS00880	COG1122	ATPase activity
JR441_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JR441_RS00890	COG0101	tRNA pseudouridine synthase activity
JR441_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JR441_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JR441_RS00905	COG2226	methyltransferase
JR441_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_RS00920	COG0489	protein tyrosine kinase activity
JR441_RS00930	COG2194	sulfuric ester hydrolase activity
JR441_RS00935	COG0726	polysaccharide deacetylase
JR441_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
JR441_RS01025	COG0385	Bile acid
JR441_RS01030	COG2819	hydrolase of the alpha beta superfamily
JR441_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_RS01050	COG2207	Transcriptional regulator
JR441_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_RS01055	COG3876	Protein conserved in bacteria
JR441_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
JR441_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JR441_RS01070	COG1263	PTS System
JR441_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS01075	COG1737	Transcriptional regulator
JR441_RS01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JR441_RS01090	COG1683	Conserved Protein
JR441_RS01120	COG1595	DNA-templated transcription, initiation
JR441_RS01125	COG5662	AntiSigma factor
JR441_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JR441_RS01135	COG4856	YbbR-like protein
JR441_RS01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JR441_RS01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JR441_RS01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JR441_RS01160	COG2169	Transcriptional regulator
JR441_RS01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JR441_RS01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JR441_RS01175	COG3002	Belongs to the UPF0753 family
JR441_RS01180	COG0288	reversible hydration of carbon dioxide
JR441_RS01190	COG5609	conserved protein (DUF2294)
JR441_RS01195	COG0640	Transcriptional regulator
JR441_RS01200	COG2814	Major facilitator Superfamily
JR441_RS01215	COG0596	Alpha beta hydrolase
JR441_RS01220	COG0745	RESPONSE REGULATOR receiver
JR441_RS01225	COG0642	Histidine kinase
JR441_RS01235	COG0515	serine threonine protein kinase
JR441_RS01250	COG1113	amino acid transport
JR441_RS01265	COG2602	Beta-lactamase
JR441_RS01270	COG2124	cytochrome p450
JR441_RS01280	COG0531	amino acid
JR441_RS01285	COG0584	glycerophosphoryl diester phosphodiesterase
JR441_RS01290	COG2271	Major facilitator Superfamily
JR441_RS01300	COG0456	acetyltransferase
JR441_RS01300	COG1846	Transcriptional regulator
JR441_RS01305	COG2271	Major facilitator Superfamily
JR441_RS01310	COG0697	spore germination
JR441_RS01315	COG2207	Transcriptional regulator
JR441_RS01315	COG1917	Cupin 2, conserved barrel domain protein
JR441_RS01320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JR441_RS01325	COG3591	Belongs to the peptidase S1B family
JR441_RS01335	COG0596	Alpha beta hydrolase
JR441_RS01340	COG1183	phosphatidylcholine synthase activity
JR441_RS01345	COG0586	Pfam SNARE associated Golgi protein
JR441_RS01350	COG0688	phosphatidylethanolamine metabolic process
JR441_RS01360	COG2312	Erythromycin esterase
JR441_RS01365	COG2207	Transcriptional regulator
JR441_RS01370	COG1054	Belongs to the UPF0176 family
JR441_RS01375	COG1301	dicarboxylic acid transport
JR441_RS01380	COG2190	(PTS) system
JR441_RS01380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS01380	COG1263	PTS System
JR441_RS01385	COG0363	glucosamine-6-phosphate deaminase activity
JR441_RS01390	COG2188	Transcriptional regulator
JR441_RS01400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JR441_RS01405	COG0833	amino acid
JR441_RS01410	COG2040	homocysteine
JR441_RS01415	COG1115	amino acid carrier protein
JR441_RS01420	COG2066	Belongs to the glutaminase family
JR441_RS01425	COG4191	Histidine kinase
JR441_RS01430	COG0784	Response regulator, receiver
JR441_RS01435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JR441_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS01445	COG2271	Major facilitator Superfamily
JR441_RS01450	COG4948	Mandelate Racemase Muconate Lactonizing
JR441_RS01455	COG2186	Transcriptional regulator
JR441_RS01460	COG2721	sulfolactate sulfo-lyase activity
JR441_RS01465	COG3173	Aminoglycoside phosphotransferase
JR441_RS01475	COG0697	spore germination
JR441_RS01480	COG0745	RESPONSE REGULATOR receiver
JR441_RS01485	COG2205	protein histidine kinase activity
JR441_RS01490	COG1131	(ABC) transporter
JR441_RS01510	COG3773	Cell wall hydrolase
JR441_RS01515	COG2304	oxidoreductase activity
JR441_RS01525	COG3540	Alkaline phosphatase
JR441_RS01530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JR441_RS01535	COG0805	protein transport
JR441_RS01540	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JR441_RS01545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JR441_RS01550	COG0477	Major facilitator Superfamily
JR441_RS01555	COG1309	transcriptional regulator
JR441_RS01560	COG0252	asparaginase activity
JR441_RS01565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JR441_RS01570	COG1714	RDD family
JR441_RS01575	COG1405	negative regulation of cell septum assembly
JR441_RS01575	COG3012	SEC-C Motif Domain Protein
JR441_RS01580	COG3290	protein histidine kinase activity
JR441_RS01585	COG3279	Response regulator of the LytR AlgR family
JR441_RS01590	COG4555	ABC transporter
JR441_RS01595	COG1668	transmembrane transport
JR441_RS01600	COG0667	Aldo Keto reductase
JR441_RS01620	COG1595	DNA-templated transcription, initiation
JR441_RS01625	COG1876	peptidase activity
JR441_RS01630	COG0457	Tetratricopeptide repeat
JR441_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS01640	COG0366	Alpha amylase catalytic
JR441_RS01645	COG0803	Belongs to the bacterial solute-binding protein 9 family
JR441_RS01650	COG1121	(ABC) transporter
JR441_RS01655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JR441_RS01660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_RS01665	COG2310	stress, protein
JR441_RS01670	COG2310	stress, protein
JR441_RS01675	COG2310	stress, protein
JR441_RS01680	COG0861	Integral membrane protein TerC family
JR441_RS01690	COG3853	Toxic anion resistance protein (TelA)
JR441_RS01695	COG0477	Major facilitator Superfamily
JR441_RS01700	COG2814	Major facilitator Superfamily
JR441_RS01705	COG0640	Transcriptional regulator
JR441_RS01710	COG0517	IMP dehydrogenase activity
JR441_RS01710	COG4175	Glycine betaine
JR441_RS01715	COG4176	ABC-type proline glycine betaine transport system permease component
JR441_RS01720	COG2113	Glycine betaine
JR441_RS01725	COG1473	amidohydrolase
JR441_RS01730	COG1288	antiporter activity
JR441_RS01740	COG0366	Alpha amylase catalytic
JR441_RS01745	COG0039	L-malate dehydrogenase activity
JR441_RS01750	COG1620	l-lactate permease
JR441_RS01755	COG2814	Major facilitator Superfamily
JR441_RS01760	COG1846	Transcriptional regulator
JR441_RS01765	COG1280	lysine exporter protein (LysE YggA)
JR441_RS01770	COG3403	YqcI/YcgG family
JR441_RS01775	COG1113	amino acid transport
JR441_RS01780	COG3665	Urea carboxylase-associated protein
JR441_RS01785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JR441_RS01790	COG1660	Displays ATPase and GTPase activities
JR441_RS01795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JR441_RS01800	COG2226	methyltransferase
JR441_RS01805	COG0583	DNA-binding transcription factor activity
JR441_RS01810	COG3458	cephalosporin-C deacetylase activity
JR441_RS01815	COG3541	Predicted nucleotidyltransferase
JR441_RS01820	COG0506	proline dehydrogenase activity
JR441_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS01830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_RS01835	COG2508	Transcriptional regulator
JR441_RS01840	COG3689	TIGRFAM TIGR03943 family protein
JR441_RS01845	COG0701	Predicted permease
JR441_RS01850	COG2267	carboxylic ester hydrolase activity
JR441_RS01855	COG0492	ferredoxin-NADP+ reductase activity
JR441_RS01860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JR441_RS01860	COG1587	Uroporphyrinogen-III synthase
JR441_RS01865	COG2146	nitrite reductase [NAD(P)H] activity
JR441_RS01870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JR441_RS01875	COG0243	molybdopterin cofactor binding
JR441_RS01880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JR441_RS01885	COG2223	nitrite transmembrane transporter activity
JR441_RS01890	COG1469	GTP cyclohydrolase I activity
JR441_RS01905	COG0523	cobalamin synthesis protein
JR441_RS01910	COG0765	amino acid transport
JR441_RS01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_RS01925	COG1714	RDD family
JR441_RS01935	COG2723	6-phospho-beta-galactosidase activity
JR441_RS01945	COG3209	COG3209 Rhs family protein
JR441_RS01950	COG3290	protein histidine kinase activity
JR441_RS01950	COG0840	transmembrane signaling receptor activity
JR441_RS01955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JR441_RS01960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JR441_RS01965	COG1733	regulation of RNA biosynthetic process
JR441_RS01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS01985	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
JR441_RS02000	COG0697	spore germination
JR441_RS02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_RS02015	COG2364	Membrane
JR441_RS02020	COG1126	abc transporter atp-binding protein
JR441_RS02025	COG0765	amino acid transport
JR441_RS02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_RS02035	COG0583	DNA-binding transcription factor activity
JR441_RS02040	COG0163	prenyltransferase activity
JR441_RS02045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JR441_RS02060	COG0596	Alpha beta hydrolase
JR441_RS02065	COG3104	oligopeptide transport
JR441_RS02070	COG5434	Belongs to the glycosyl hydrolase 28 family
JR441_RS02080	COG0697	spore germination
JR441_RS02090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JR441_RS02095	COG1136	(ABC) transporter
JR441_RS02100	COG0577	efflux transmembrane transporter activity
JR441_RS02105	COG0745	RESPONSE REGULATOR receiver
JR441_RS02110	COG3850	Histidine kinase
JR441_RS02110	COG5002	protein histidine kinase activity
JR441_RS02115	COG0457	Tetratricopeptide repeat
JR441_RS02135	COG0527	aspartate kinase activity
JR441_RS02140	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS02145	COG4605	iron ion homeostasis
JR441_RS02150	COG4604	ABC transporter, ATP-binding protein
JR441_RS02155	COG4607	ABC-type enterochelin transport system periplasmic component
JR441_RS02160	COG2814	Major facilitator Superfamily
JR441_RS02165	COG1309	transcriptional regulator
JR441_RS02170	COG0778	Nitroreductase
JR441_RS02175	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JR441_RS02180	COG0640	Transcriptional regulator
JR441_RS02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_RS02190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JR441_RS02195	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS02220	COG4975	Glucose uptake
JR441_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS02230	COG4549	nuclear export factor GLE1
JR441_RS02235	COG2372	response to copper ion
JR441_RS02235	COG1276	copper resistance
JR441_RS02240	COG1349	DNA-binding transcription factor activity
JR441_RS02250	COG2213	PTS system mannitol-specific
JR441_RS02255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_RS02260	COG0246	Mannitol dehydrogenase
JR441_RS02265	COG0473	3-isopropylmalate dehydrogenase activity
JR441_RS02270	COG0681	Belongs to the peptidase S26 family
JR441_RS02275	COG0412	Dienelactone hydrolase
JR441_RS02280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JR441_RS02290	COG0561	phosphatase activity
JR441_RS02295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JR441_RS02300	COG1914	H( )-stimulated, divalent metal cation uptake system
JR441_RS02305	COG4336	lyase activity
JR441_RS02310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JR441_RS02315	COG1984	allophanate hydrolase subunit 2
JR441_RS02320	COG1414	Transcriptional regulator
JR441_RS02325	COG2755	lipolytic protein G-D-S-L family
JR441_RS02335	COG2329	Antibiotic biosynthesis monooxygenase
JR441_RS02340	COG0768	penicillin binding
JR441_RS02345	COG4989	oxidoreductase activity
JR441_RS02350	COG3711	transcriptional antiterminator
JR441_RS02355	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_RS02360	COG2226	methyltransferase
JR441_RS02365	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS02370	COG1917	Cupin 2, conserved barrel domain protein
JR441_RS02375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_RS02380	COG3871	stress protein (general stress protein 26)
JR441_RS02390	COG2814	Major facilitator Superfamily
JR441_RS02395	COG1522	sequence-specific DNA binding
JR441_RS02400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JR441_RS02400	COG0551	DNA topoisomerase type I activity
JR441_RS02405	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
JR441_RS02410	COG3706	GGDEF domain
JR441_RS02415	COG5298	Protein conserved in bacteria
JR441_RS02420	COG1215	transferase activity, transferring glycosyl groups
JR441_RS02430	COG0531	amino acid
JR441_RS02435	COG0494	nUDIX hydrolase
JR441_RS02440	COG0028	Belongs to the TPP enzyme family
JR441_RS02455	COG1914	H( )-stimulated, divalent metal cation uptake system
JR441_RS02460	COG2261	transglycosylase associated protein
JR441_RS02465	COG4876	unkown
JR441_RS02470	COG2217	Heavy metal translocating P-type atpase
JR441_RS02475	COG3729	General stress protein
JR441_RS02480	COG0662	Cupin 2, conserved barrel domain protein
JR441_RS02485	COG2329	Antibiotic biosynthesis monooxygenase
JR441_RS02490	COG3546	catalase activity
JR441_RS02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JR441_RS02500	COG3290	protein histidine kinase activity
JR441_RS02505	COG4565	transcriptional regulatory protein
JR441_RS02510	COG1301	dicarboxylic acid transport
JR441_RS02515	COG0628	permease
JR441_RS02520	COG1131	(ABC) transporter
JR441_RS02525	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
JR441_RS02535	COG1960	acyl-CoA dehydrogenase activity
JR441_RS02550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JR441_RS02555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_RS02560	COG1181	Belongs to the D-alanine--D-alanine ligase family
JR441_RS02565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JR441_RS02570	COG0513	Belongs to the DEAD box helicase family
JR441_RS02575	COG3402	PFAM membrane-flanked domain
JR441_RS02580	COG3428	Bacterial PH domain
JR441_RS02585	COG0705	Rhomboid family
JR441_RS02590	COG0736	holo-[acyl-carrier-protein] synthase activity
JR441_RS02595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JR441_RS02600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JR441_RS02605	COG0864	Transcriptional regulator
JR441_RS02610	COG2337	Toxic component of a toxin-antitoxin (TA) module
JR441_RS02615	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_RS02620	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_RS02625	COG2172	sigma factor antagonist activity
JR441_RS02630	COG2208	phosphoserine phosphatase activity
JR441_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_RS02640	COG2172	sigma factor antagonist activity
JR441_RS02645	COG1191	sigma factor activity
JR441_RS02650	COG2208	phosphoserine phosphatase activity
JR441_RS02655	COG2183	response to ionizing radiation
JR441_RS02665	COG3091	SprT-like family
JR441_RS02705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_RS02715	COG5444	nuclease activity
JR441_RS02720	COG1476	TRANSCRIPTIONal
JR441_RS02730	COG3239	Fatty acid desaturase
JR441_RS02735	COG1278	Cold shock
JR441_RS02740	COG1329	Transcriptional regulator
JR441_RS02745	COG0697	spore germination
JR441_RS02750	COG1917	Cupin 2, conserved barrel domain protein
JR441_RS02750	COG2207	Transcriptional regulator
JR441_RS02755	COG0697	spore germination
JR441_RS02760	COG3708	Transcriptional regulator
JR441_RS02760	COG2207	Transcriptional regulator
JR441_RS02765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_RS02770	COG0477	Major facilitator Superfamily
JR441_RS02780	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
JR441_RS02800	COG1309	transcriptional regulator
JR441_RS02805	COG0697	spore germination
JR441_RS02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_RS02815	COG2030	dehydratase
JR441_RS02820	COG3545	Serine hydrolase
JR441_RS02825	COG1733	regulation of RNA biosynthetic process
JR441_RS02830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_RS02835	COG2814	Major facilitator Superfamily
JR441_RS02840	COG1309	transcriptional regulator
JR441_RS02845	COG0640	Transcriptional regulator
JR441_RS02850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JR441_RS02860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_RS02865	COG0697	spore germination
JR441_RS02870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_RS02875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JR441_RS02880	COG0640	Transcriptional regulator
JR441_RS02885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JR441_RS02900	COG4585	Histidine kinase
JR441_RS02905	COG2197	response regulator
JR441_RS02910	COG2409	Drug exporters of the RND superfamily
JR441_RS02915	COG0596	Alpha beta hydrolase
JR441_RS02920	COG1811	Na channel or pump
JR441_RS02925	COG0789	Transcriptional regulator
JR441_RS02925	COG4978	Transcriptional regulator
JR441_RS02930	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JR441_RS02935	COG0778	Nitroreductase
JR441_RS02940	COG0346	lactoylglutathione lyase activity
JR441_RS02945	COG2259	Doxx family
JR441_RS02950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_RS02965	COG2323	membrane
JR441_RS02970	COG2323	membrane
JR441_RS02975	COG0071	Belongs to the small heat shock protein (HSP20) family
JR441_RS02990	COG1309	transcriptional regulator
JR441_RS03000	COG0456	acetyltransferase
JR441_RS03005	COG0488	(ABC) transporter
JR441_RS03010	COG1113	amino acid transport
JR441_RS03015	COG2318	DinB family
JR441_RS03020	COG1846	Transcriptional regulator
JR441_RS03025	COG1033	growth of symbiont in host cell
JR441_RS03025	COG2409	Drug exporters of the RND superfamily
JR441_RS03030	COG0778	Nitroreductase
JR441_RS03035	COG1846	Transcriptional regulator
JR441_RS03040	COG2814	Major facilitator Superfamily
JR441_RS03045	COG0730	response to heat
JR441_RS03050	COG1802	Transcriptional regulator
JR441_RS03055	COG1388	LysM domain
JR441_RS03055	COG3858	chitin binding
JR441_RS03060	COG1819	glycosyl
JR441_RS03070	COG1785	Belongs to the alkaline phosphatase family
JR441_RS03075	COG5646	InterPro IPR014922
JR441_RS03085	COG0454	-acetyltransferase
JR441_RS03090	COG1078	dGTPase activity
JR441_RS03095	COG1388	LysM domain
JR441_RS03100	COG2814	Major facilitator Superfamily
JR441_RS03105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_RS03110	COG1447	Phosphotransferase system cellobiose-specific component IIA
JR441_RS03115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_RS03120	COG2723	6-phospho-beta-galactosidase activity
JR441_RS03125	COG2188	Transcriptional regulator
JR441_RS03130	COG1940	carbohydrate kinase activity
JR441_RS03135	COG1482	cell wall glycoprotein biosynthetic process
JR441_RS03140	COG4124	Belongs to the glycosyl hydrolase 26 family
JR441_RS03185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JR441_RS03190	COG0802	atpase or kinase
JR441_RS03195	COG1214	PFAM Peptidase M22, glycoprotease
JR441_RS03200	COG0456	acetyltransferase
JR441_RS03205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JR441_RS03210	COG0488	(ABC) transporter
JR441_RS03215	COG0315	cyclic pyranopterin monophosphate synthase activity
JR441_RS03220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JR441_RS03225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JR441_RS03230	COG0805	protein transport
JR441_RS03240	COG1266	CAAX protease self-immunity
JR441_RS03250	COG0459	protein refolding
JR441_RS03255	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JR441_RS03270	COG0457	Tetratricopeptide repeat
JR441_RS03275	COG1063	alcohol dehydrogenase
JR441_RS03280	COG2211	Major facilitator Superfamily
JR441_RS03285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_RS03290	COG1842	Phage shock protein A
JR441_RS03295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JR441_RS03300	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JR441_RS03305	COG4260	virion core protein, lumpy skin disease virus
JR441_RS03315	COG2814	Major facilitator Superfamily
JR441_RS03320	COG1063	alcohol dehydrogenase
JR441_RS03325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JR441_RS03330	COG0823	Involved in the tonB-independent uptake of proteins
JR441_RS03345	COG2267	carboxylic ester hydrolase activity
JR441_RS03355	COG2132	Multicopper oxidase
JR441_RS03360	COG1113	amino acid transport
JR441_RS03370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JR441_RS03375	COG0714	Associated with various cellular activities
JR441_RS03380	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
JR441_RS03385	COG1305	Transglutaminase-like
JR441_RS03390	COG0519	Catalyzes the synthesis of GMP from XMP
JR441_RS03390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JR441_RS03405	COG2252	PERMEase
JR441_RS03410	COG3064	Membrane
JR441_RS03420	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JR441_RS03430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JR441_RS03435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JR441_RS03440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JR441_RS03445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JR441_RS03450	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JR441_RS03455	COG0047	phosphoribosylformylglycinamidine synthase activity
JR441_RS03460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JR441_RS03465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JR441_RS03470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JR441_RS03475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JR441_RS03480	COG0138	bifunctional purine biosynthesis protein purh
JR441_RS03485	COG0151	Belongs to the GarS family
JR441_RS03490	COG1522	sequence-specific DNA binding
JR441_RS03495	COG0531	amino acid
JR441_RS03505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JR441_RS03510	COG1470	cell adhesion involved in biofilm formation
JR441_RS03515	COG4496	protein, YerC YecD
JR441_RS03520	COG0069	glutamate synthase activity
JR441_RS03525	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JR441_RS03530	COG0210	DNA helicase
JR441_RS03535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JR441_RS03540	COG4851	CamS sex pheromone cAM373 precursor
JR441_RS03545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_RS03550	COG1285	pathogenesis
JR441_RS03555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_RS03560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JR441_RS03565	COG0154	amidase activity
JR441_RS03570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JR441_RS03575	COG1309	transcriptional regulator
JR441_RS03580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JR441_RS03585	COG1597	lipid kinase activity
JR441_RS03590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JR441_RS03620	COG3391	amine dehydrogenase activity
JR441_RS03630	COG0457	Tetratricopeptide repeat
JR441_RS03640	COG0217	transcriptional regulatory protein
JR441_RS03660	COG3546	catalase activity
JR441_RS03665	COG0454	-acetyltransferase
JR441_RS03675	COG5578	integral membrane protein
JR441_RS03680	COG2972	Histidine kinase
JR441_RS03685	COG2207	Transcriptional regulator
JR441_RS03685	COG4753	response regulator
JR441_RS03690	COG1653	transport
JR441_RS03695	COG1175	transmembrane transport
JR441_RS03700	COG0395	ABC-type sugar transport system, permease component
JR441_RS03705	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JR441_RS03710	COG2207	Transcriptional regulator
JR441_RS03715	COG2755	lipolytic protein G-D-S-L family
JR441_RS03725	COG5578	integral membrane protein
JR441_RS03730	COG3401	FG-GAP repeat protein
JR441_RS03735	COG3401	FG-GAP repeat protein
JR441_RS03740	COG2755	lipolytic protein G-D-S-L family
JR441_RS03745	COG1874	Beta-galactosidase
JR441_RS03755	COG1653	transport
JR441_RS03760	COG4209	transmembrane transport
JR441_RS03765	COG0395	ABC-type sugar transport system, permease component
JR441_RS03770	COG1486	melibiose metabolic process
JR441_RS03775	COG2323	membrane
JR441_RS03780	COG2329	Antibiotic biosynthesis monooxygenase
JR441_RS03785	COG0346	lactoylglutathione lyase activity
JR441_RS03800	COG5583	Uncharacterized small protein (DUF2292)
JR441_RS03805	COG0670	Belongs to the BI1 family
JR441_RS03825	COG2124	cytochrome p450
JR441_RS03825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JR441_RS03830	COG1368	sulfuric ester hydrolase activity
JR441_RS03835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JR441_RS03840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_RS03845	COG1442	glycosyl transferase family 8
JR441_RS03850	COG1216	Glycosyl transferase, family 2
JR441_RS03855	COG1442	glycosyl transferase family 8
JR441_RS03860	COG2223	nitrite transmembrane transporter activity
JR441_RS03865	COG1011	Hydrolase
JR441_RS03870	COG0531	amino acid
JR441_RS03875	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS03880	COG0840	transmembrane signaling receptor activity
JR441_RS03885	COG0488	(ABC) transporter
JR441_RS03895	COG0789	Transcriptional regulator
JR441_RS03900	COG2814	Major facilitator Superfamily
JR441_RS03910	COG0488	(ABC) transporter
JR441_RS03915	COG0513	Belongs to the DEAD box helicase family
JR441_RS03920	COG0456	acetyltransferase
JR441_RS03925	COG2130	NADP-dependent
JR441_RS03930	COG1120	ATPase activity
JR441_RS03935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS03945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JR441_RS03960	COG3866	Pectate lyase
JR441_RS03965	COG0471	metal ion transport
JR441_RS03970	COG3290	protein histidine kinase activity
JR441_RS03975	COG4565	transcriptional regulatory protein
JR441_RS03980	COG3181	Tripartite tricarboxylate transporter family receptor
JR441_RS03985	COG2851	Citrate transporter
JR441_RS03990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_RS03995	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
JR441_RS04000	COG1254	Belongs to the acylphosphatase family
JR441_RS04005	COG2258	MOSC domain
JR441_RS04025	COG0024	Methionine aminopeptidase
JR441_RS04030	COG1263	PTS System
JR441_RS04030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS04035	COG1368	sulfuric ester hydrolase activity
JR441_RS04050	COG1115	amino acid carrier protein
JR441_RS04055	COG0531	amino acid
JR441_RS04070	COG0697	spore germination
JR441_RS04075	COG1263	PTS System
JR441_RS04075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS04080	COG0366	Alpha amylase catalytic
JR441_RS04085	COG2188	Transcriptional regulator
JR441_RS04090	COG0778	Nitroreductase
JR441_RS04095	COG0737	Belongs to the 5'-nucleotidase family
JR441_RS04100	COG0693	protein deglycase activity
JR441_RS04105	COG2814	Major facilitator Superfamily
JR441_RS04110	COG4840	Belongs to the UPF0435 family
JR441_RS04115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JR441_RS04120	COG4980	gas vesicle protein
JR441_RS04125	COG1295	ribonuclease BN
JR441_RS04130	COG0477	Major facilitator Superfamily
JR441_RS04135	COG0387	Pfam Sodium calcium exchanger
JR441_RS04145	COG0668	transmembrane transport
JR441_RS04150	COG0535	radical SAM domain protein
JR441_RS04160	COG0726	polysaccharide deacetylase
JR441_RS04165	COG2084	Dehydrogenase
JR441_RS04170	COG0598	Magnesium transport protein CorA
JR441_RS04175	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JR441_RS04180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JR441_RS04190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JR441_RS04195	COG4637	Psort location Cytoplasmic, score
JR441_RS04200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JR441_RS04205	COG0022	dehydrogenase e1 component
JR441_RS04210	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR441_RS04215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JR441_RS04220	COG3284	Transcriptional regulator
JR441_RS04230	COG1742	UPF0060 membrane protein
JR441_RS04255	COG4842	Belongs to the WXG100 family
JR441_RS04260	COG1486	melibiose metabolic process
JR441_RS04265	COG1737	Transcriptional regulator
JR441_RS04270	COG1263	PTS System
JR441_RS04270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS04275	COG5434	Belongs to the glycosyl hydrolase 28 family
JR441_RS04280	COG1132	(ABC) transporter
JR441_RS04285	COG1132	(ABC) transporter
JR441_RS04290	COG2259	Doxx family
JR441_RS04295	COG2514	catechol 2,3-dioxygenase activity
JR441_RS04300	COG4585	Histidine kinase
JR441_RS04305	COG2197	response regulator
JR441_RS04310	COG1131	(ABC) transporter
JR441_RS04315	COG1511	domain protein
JR441_RS04315	COG0842	Transport permease protein
JR441_RS04320	COG0842	Transport permease protein
JR441_RS04325	COG1695	Transcriptional regulator
JR441_RS04335	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
JR441_RS04340	COG1309	transcriptional regulator
JR441_RS04345	COG2814	Major facilitator Superfamily
JR441_RS04350	COG2318	DinB family
JR441_RS04355	COG2814	Major facilitator Superfamily
JR441_RS04360	COG1846	Transcriptional regulator
JR441_RS04365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JR441_RS04365	COG0392	lysyltransferase activity
JR441_RS04370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_RS04375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS04380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS04385	COG0384	phenazine biosynthesis protein PhzF
JR441_RS04390	COG0778	Nitroreductase
JR441_RS04405	COG1090	epimerase
JR441_RS04410	COG2137	regulation of response to DNA damage stimulus
JR441_RS04420	COG2814	Major facilitator Superfamily
JR441_RS04435	COG3103	Sh3 type 3 domain protein
JR441_RS04440	COG5658	integral membrane protein
JR441_RS04445	COG0596	Alpha beta hydrolase
JR441_RS04450	COG0463	Glycosyl transferase, family 2
JR441_RS04455	COG4485	Bacterial membrane protein, YfhO
JR441_RS04460	COG1988	membrane-bound metal-dependent
JR441_RS04465	COG1194	a g-specific adenine glycosylase
JR441_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS04490	COG3557	Belongs to the UPF0374 family
JR441_RS04495	COG1132	(ABC) transporter
JR441_RS04500	COG4129	membrane
JR441_RS04505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JR441_RS04510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JR441_RS04515	COG0735	belongs to the Fur family
JR441_RS04625	COG4326	sporulation control protein
JR441_RS04635	COG5577	PFAM Coat F domain
JR441_RS04645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JR441_RS04650	COG0277	FAD linked oxidase domain protein
JR441_RS04660	COG0753	catalase activity
JR441_RS04665	COG1116	anion transmembrane transporter activity
JR441_RS04670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JR441_RS04675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JR441_RS04680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_RS04690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JR441_RS04700	COG1476	TRANSCRIPTIONal
JR441_RS04710	COG3382	B3 4 domain protein
JR441_RS04715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JR441_RS04725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JR441_RS04730	COG0789	Transcriptional regulator
JR441_RS04740	COG1664	Polymer-forming cytoskeletal
JR441_RS04745	COG2766	serine protein kinase
JR441_RS04750	COG2718	Belongs to the UPF0229 family
JR441_RS04755	COG1846	Transcriptional regulator
JR441_RS04760	COG1566	PFAM secretion protein HlyD family protein
JR441_RS04765	COG2814	Major facilitator Superfamily
JR441_RS04770	COG0655	NAD(P)H dehydrogenase (quinone) activity
JR441_RS04790	COG1725	Transcriptional regulator
JR441_RS04795	COG1131	(ABC) transporter
JR441_RS04800	COG1131	(ABC) transporter
JR441_RS04805	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
JR441_RS04810	COG1278	Cold shock
JR441_RS04815	COG1464	Belongs to the NlpA lipoprotein family
JR441_RS04820	COG3706	GGDEF domain
JR441_RS04825	COG1823	symporter activity
JR441_RS04845	COG5577	PFAM Coat F domain
JR441_RS04850	COG4085	toxin activity
JR441_RS04850	COG0737	Belongs to the 5'-nucleotidase family
JR441_RS04850	COG1525	nuclease
JR441_RS04855	COG3764	Sortase (surface protein transpeptidase)
JR441_RS04860	COG0564	pseudouridine synthase activity
JR441_RS04870	COG0517	IMP dehydrogenase activity
JR441_RS04875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JR441_RS04880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JR441_RS04880	COG3153	acetyltransferase
JR441_RS04885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JR441_RS04890	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JR441_RS04895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JR441_RS04900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JR441_RS04905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JR441_RS04910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JR441_RS04915	COG4585	Histidine kinase
JR441_RS04915	COG2203	Gaf domain
JR441_RS04920	COG2197	response regulator
JR441_RS04925	COG0431	NADPH-dependent FMN reductase
JR441_RS04940	COG1388	LysM domain
JR441_RS04940	COG0791	NLP P60 protein
JR441_RS04945	COG1959	2 iron, 2 sulfur cluster binding
JR441_RS04950	COG0668	transmembrane transport
JR441_RS04955	COG2719	SpoVR family
JR441_RS04960	COG1785	Belongs to the alkaline phosphatase family
JR441_RS04965	COG1388	LysM domain
JR441_RS04965	COG0791	NLP P60 protein
JR441_RS04970	COG0583	DNA-binding transcription factor activity
JR441_RS04975	COG0372	Belongs to the citrate synthase family
JR441_RS04980	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS04985	COG0531	amino acid
JR441_RS04990	COG0733	neurotransmitter:sodium symporter activity
JR441_RS05000	COG0456	acetyltransferase
JR441_RS05015	COG1595	DNA-templated transcription, initiation
JR441_RS05020	COG0667	Aldo Keto reductase
JR441_RS05025	COG0204	Acyl-transferase
JR441_RS05030	COG1253	flavin adenine dinucleotide binding
JR441_RS05035	COG0789	Transcriptional regulator
JR441_RS05040	COG0436	Aminotransferase
JR441_RS05045	COG1253	flavin adenine dinucleotide binding
JR441_RS05050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JR441_RS05055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JR441_RS05060	COG0584	glycerophosphoryl diester phosphodiesterase
JR441_RS05070	COG0668	transmembrane transport
JR441_RS05075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JR441_RS05080	COG0726	polysaccharide deacetylase
JR441_RS05085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JR441_RS05090	COG1757	Na H antiporter
JR441_RS05095	COG0589	response to stress
JR441_RS05105	COG1132	(ABC) transporter
JR441_RS05110	COG1132	(ABC) transporter
JR441_RS05115	COG0702	epimerase
JR441_RS05135	COG0189	ligase activity
JR441_RS05140	COG0189	ligase activity
JR441_RS05145	COG4399	Belongs to the UPF0754 family
JR441_RS05150	COG3679	Belongs to the UPF0342 family
JR441_RS05155	COG4335	DNA alkylation repair
JR441_RS05160	COG0561	phosphatase activity
JR441_RS05165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JR441_RS05170	COG0475	glutathione-regulated potassium exporter activity
JR441_RS05175	COG0490	domain, Protein
JR441_RS05185	COG1024	Enoyl-CoA hydratase
JR441_RS05195	COG4152	abc transporter atp-binding protein
JR441_RS05200	COG1668	transmembrane transport
JR441_RS05205	COG0420	3'-5' exonuclease activity
JR441_RS05210	COG4717	serine-type aminopeptidase activity
JR441_RS05215	COG3481	metal-dependent phosphohydrolase, HD sub domain
JR441_RS05225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JR441_RS05255	COG1846	Transcriptional regulator
JR441_RS05260	COG4980	gas vesicle protein
JR441_RS05275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JR441_RS05280	COG0537	adenosine 5'-monophosphoramidase activity
JR441_RS05285	COG1131	(ABC) transporter
JR441_RS05290	COG4473	ABC transporter
JR441_RS05300	COG1473	amidohydrolase
JR441_RS05305	COG3069	C4-dicarboxylate transmembrane transporter activity
JR441_RS05315	COG2329	Antibiotic biosynthesis monooxygenase
JR441_RS05320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JR441_RS05325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JR441_RS05330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JR441_RS05335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JR441_RS05340	COG1309	transcriptional regulator
JR441_RS05345	COG1511	domain protein
JR441_RS05350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JR441_RS05355	COG4377	Putative membrane peptidase family (DUF2324)
JR441_RS05365	COG1363	Peptidase, m42
JR441_RS05370	COG4405	Protein conserved in bacteria
JR441_RS05375	COG1301	dicarboxylic acid transport
JR441_RS05385	COG1234	tRNA 3'-trailer cleavage
JR441_RS05390	COG0095	Lipoate-protein ligase
JR441_RS05395	COG0702	epimerase
JR441_RS05400	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_RS05410	COG0501	Belongs to the peptidase M48B family
JR441_RS05420	COG0456	acetyltransferase
JR441_RS05425	COG0604	alcohol dehydrogenase
JR441_RS05430	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JR441_RS05435	COG0406	alpha-ribazole phosphatase activity
JR441_RS05440	COG0183	Belongs to the thiolase family
JR441_RS05445	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_RS05450	COG1268	BioY protein
JR441_RS05455	COG0840	transmembrane signaling receptor activity
JR441_RS05460	COG0723	plastoquinol--plastocyanin reductase activity
JR441_RS05460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JR441_RS05465	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS05475	COG4903	ComK protein
JR441_RS05480	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS05490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_RS05505	COG0398	Pfam SNARE associated Golgi protein
JR441_RS05510	COG0681	Belongs to the peptidase S26 family
JR441_RS05515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JR441_RS05520	COG1846	Transcriptional regulator
JR441_RS05525	COG0738	Major facilitator superfamily
JR441_RS05530	COG0673	inositol 2-dehydrogenase activity
JR441_RS05535	COG0561	phosphatase activity
JR441_RS05540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JR441_RS05545	COG1609	Transcriptional regulator
JR441_RS05550	COG3180	Ammonia monooxygenase
JR441_RS05555	COG0477	Major facilitator Superfamily
JR441_RS05555	COG2814	Major facilitator Superfamily
JR441_RS05560	COG4533	DNA binding
JR441_RS05570	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
JR441_RS05575	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JR441_RS05580	COG1074	ATP-dependent DNA helicase activity
JR441_RS05585	COG0420	3'-5' exonuclease activity
JR441_RS05590	COG0419	ATPase involved in DNA repair
JR441_RS05595	COG1403	HNH endonuclease
JR441_RS05635	COG5337	Spore coat protein CotH
JR441_RS05640	COG0179	Fumarylacetoacetate (FAA) hydrolase
JR441_RS05650	COG1404	Belongs to the peptidase S8 family
JR441_RS05660	COG0367	asparagine synthase
JR441_RS05665	COG2318	DinB family
JR441_RS05670	COG1562	ergosterol biosynthetic process
JR441_RS05675	COG0534	Mate efflux family protein
JR441_RS05680	COG2207	Transcriptional regulator
JR441_RS05680	COG1917	Cupin 2, conserved barrel domain protein
JR441_RS05685	COG1609	Transcriptional regulator
JR441_RS05690	COG0673	inositol 2-dehydrogenase activity
JR441_RS05695	COG2318	DinB family
JR441_RS05700	COG1279	arginine transmembrane transporter activity
JR441_RS05705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_RS05710	COG1357	PFAM Pentapeptide repeats (8 copies)
JR441_RS05715	COG2267	carboxylic ester hydrolase activity
JR441_RS05720	COG0529	Catalyzes the synthesis of activated sulfate
JR441_RS05725	COG2046	Belongs to the sulfate adenylyltransferase family
JR441_RS05730	COG0175	sulfate reduction
JR441_RS05735	COG2045	Belongs to the ComB family
JR441_RS05740	COG1809	phosphosulfolactate synthase activity
JR441_RS05745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_RS05750	COG4948	Mandelate Racemase Muconate Lactonizing
JR441_RS05755	COG2814	Major facilitator Superfamily
JR441_RS05760	COG0454	-acetyltransferase
JR441_RS05765	COG2153	protein acetylation
JR441_RS05770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JR441_RS05770	COG0646	methionine synthase
JR441_RS05775	COG1666	GTP binding
JR441_RS05780	COG2996	Protein conserved in bacteria
JR441_RS05800	COG1695	Transcriptional regulator
JR441_RS05815	COG3227	Zinc metalloprotease (Elastase)
JR441_RS05820	COG1307	EDD domain protein, DegV family
JR441_RS05825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_RS05845	COG0561	phosphatase activity
JR441_RS05850	COG1073	alpha beta
JR441_RS05855	COG2151	metal-sulfur cluster biosynthetic enzyme
JR441_RS05865	COG0277	FAD linked oxidase domain protein
JR441_RS05870	COG2271	Major facilitator Superfamily
JR441_RS05875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JR441_RS05880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JR441_RS05890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JR441_RS05895	COG0505	Belongs to the CarA family
JR441_RS05900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JR441_RS05905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JR441_RS05920	COG2267	carboxylic ester hydrolase activity
JR441_RS05930	COG1744	ABC transporter substrate-binding protein PnrA-like
JR441_RS05945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JR441_RS05950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JR441_RS05955	COG5504	Zn-dependent protease
JR441_RS05960	COG0444	Belongs to the ABC transporter superfamily
JR441_RS05965	COG4608	Belongs to the ABC transporter superfamily
JR441_RS05975	COG0601	transmembrane transport
JR441_RS05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JR441_RS05990	COG0180	Tryptophanyl-tRNA synthetase
JR441_RS05995	COG4166	transmembrane transport
JR441_RS06000	COG0601	transmembrane transport
JR441_RS06005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JR441_RS06010	COG0444	Belongs to the ABC transporter superfamily
JR441_RS06015	COG4608	Belongs to the ABC transporter superfamily
JR441_RS06020	COG2814	Major facilitator Superfamily
JR441_RS06025	COG0456	acetyltransferase
JR441_RS06030	COG1393	Belongs to the ArsC family
JR441_RS06035	COG0861	Integral membrane protein TerC family
JR441_RS06045	COG4862	establishment of competence for transformation
JR441_RS06055	COG4469	Competence protein
JR441_RS06060	COG1164	Oligoendopeptidase f
JR441_RS06070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JR441_RS06075	COG2346	COG2346, Truncated hemoglobins
JR441_RS06080	COG0741	lytic transglycosylase activity
JR441_RS06085	COG4116	CYTH
JR441_RS06095	COG2357	RelA SpoT domain protein
JR441_RS06100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JR441_RS06105	COG0564	pseudouridine synthase activity
JR441_RS06110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JR441_RS06115	COG0569	domain protein
JR441_RS06115	COG0475	glutathione-regulated potassium exporter activity
JR441_RS06120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JR441_RS06125	COG0352	thiamine-phosphate diphosphorylase activity
JR441_RS06130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JR441_RS06135	COG2104	thiamine diphosphate biosynthetic process
JR441_RS06140	COG2022	thiamine diphosphate biosynthetic process
JR441_RS06145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JR441_RS06150	COG0351	phosphomethylpyrimidine kinase
JR441_RS06155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JR441_RS06210	COG0210	DNA helicase
JR441_RS06220	COG2153	protein acetylation
JR441_RS06225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JR441_RS06230	COG2382	esterase
JR441_RS06235	COG0626	cystathionine gamma-synthase activity
JR441_RS06240	COG0626	cystathionine gamma-synthase activity
JR441_RS06245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_RS06250	COG5505	Protein of unknown function (DUF819)
JR441_RS06260	COG4974	Belongs to the 'phage' integrase family
JR441_RS06265	COG2856	Zn peptidase
JR441_RS06275	COG1396	sequence-specific DNA binding
JR441_RS06320	COG5377	YqaJ viral recombinase family
JR441_RS06325	COG3723	Recombinational DNA repair protein, rece pathway
JR441_RS06330	COG3935	DnaD domain protein
JR441_RS06335	COG1484	DNA-dependent DNA replication
JR441_RS06395	COG3677	Transposase
JR441_RS06410	COG5484	DNA packaging
JR441_RS06530	COG4824	toxin secretion phage lysis holin
JR441_RS06535	COG3409	Peptidoglycan-binding domain 1 protein
JR441_RS06535	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_RS06545	COG5444	nuclease activity
JR441_RS06550	COG0758	DNA mediated transformation
JR441_RS06555	COG1040	competence protein
JR441_RS06570	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JR441_RS06575	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS06585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_RS06585	COG3711	transcriptional antiterminator
JR441_RS06590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR441_RS06590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR441_RS06590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_RS06595	COG1482	cell wall glycoprotein biosynthetic process
JR441_RS06605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_RS06615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JR441_RS06630	COG0109	protoheme IX farnesyltransferase activity
JR441_RS06640	COG0726	polysaccharide deacetylase
JR441_RS06655	COG5504	Zn-dependent protease
JR441_RS06660	COG2205	protein histidine kinase activity
JR441_RS06670	COG3383	formate dehydrogenase (NAD+) activity
JR441_RS06675	COG2427	Protein of unknown function (DUF1641)
JR441_RS06685	COG1051	belongs to the nudix hydrolase family
JR441_RS06695	COG2124	cytochrome p450
JR441_RS06700	COG1819	glycosyl
JR441_RS06710	COG1587	Uroporphyrinogen-III synthase
JR441_RS06715	COG0390	transport system, permease component
JR441_RS06720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JR441_RS06725	COG0697	spore germination
JR441_RS06730	COG4297	protein containing double-stranded beta helix domain
JR441_RS06740	COG1252	NADH dehydrogenase
JR441_RS06745	COG1904	glucuronate isomerase
JR441_RS06750	COG2211	Major facilitator Superfamily
JR441_RS06755	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
JR441_RS06760	COG1063	alcohol dehydrogenase
JR441_RS06765	COG1312	Catalyzes the dehydration of D-mannonate
JR441_RS06770	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS06775	COG2271	Major facilitator Superfamily
JR441_RS06780	COG1609	Transcriptional regulator
JR441_RS06785	COG0246	Mannitol dehydrogenase
JR441_RS06790	COG2721	sulfolactate sulfo-lyase activity
JR441_RS06795	COG0730	response to heat
JR441_RS06800	COG2318	DinB family
JR441_RS06805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JR441_RS06810	COG0457	Tetratricopeptide repeat
JR441_RS06820	COG2350	Protein conserved in bacteria
JR441_RS06825	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_RS06825	COG1388	LysM domain
JR441_RS06825	COG3409	Peptidoglycan-binding domain 1 protein
JR441_RS06835	COG4195	phage-related replication protein
JR441_RS06840	COG3546	catalase activity
JR441_RS06845	COG2856	Zn peptidase
JR441_RS06850	COG1396	sequence-specific DNA binding
JR441_RS06860	COG1522	sequence-specific DNA binding
JR441_RS06865	COG1484	DNA-dependent DNA replication
JR441_RS06885	COG1595	DNA-templated transcription, initiation
JR441_RS06890	COG3728	DNA packaging
JR441_RS06890	COG5484	DNA packaging
JR441_RS06895	COG1783	phage Terminase large subunit
JR441_RS06900	COG5518	Phage portal protein
JR441_RS06905	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JR441_RS06910	COG4653	Phage capsid family
JR441_RS06960	COG5412	phage tail tape measure protein
JR441_RS06960	COG3953	SLT domain
JR441_RS06960	COG3953	SLT domain
JR441_RS06960	COG5412	phage tail tape measure protein
JR441_RS06965	COG1652	LysM domain
JR441_RS06970	COG4193	domain, Protein
JR441_RS06980	COG3628	GPW Gp25 family protein
JR441_RS06985	COG3299	homolog of phage Mu protein gp47
JR441_RS06990	COG3778	Protein conserved in bacteria
JR441_RS07030	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_RS07030	COG3409	Peptidoglycan-binding domain 1 protein
JR441_RS07035	COG3594	Acyltransferase
JR441_RS07055	COG0306	phosphate transporter
JR441_RS07060	COG1392	Phosphate transport regulator
JR441_RS07065	COG0531	amino acid
JR441_RS07070	COG0346	lactoylglutathione lyase activity
JR441_RS07075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JR441_RS07080	COG0463	Glycosyl transferase, family 2
JR441_RS07090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR441_RS07095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JR441_RS07100	COG2362	D-Aminopeptidase
JR441_RS07105	COG0601	transmembrane transport
JR441_RS07110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JR441_RS07115	COG0444	Belongs to the ABC transporter superfamily
JR441_RS07120	COG4166	transmembrane transport
JR441_RS07125	COG1619	proteins homologs of microcin C7 resistance protein MccF
JR441_RS07130	COG4948	Mandelate Racemase Muconate Lactonizing
JR441_RS07135	COG0791	NLP P60 protein
JR441_RS07140	COG4608	Belongs to the ABC transporter superfamily
JR441_RS07145	COG2706	6-phosphogluconolactonase activity
JR441_RS07150	COG1834	amidinotransferase
JR441_RS07155	COG1607	acyl-coa hydrolase
JR441_RS07160	COG1017	nitric oxide dioxygenase activity
JR441_RS07160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JR441_RS07170	COG2323	membrane
JR441_RS07175	COG2318	DinB family
JR441_RS07180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_RS07185	COG2076	Multidrug Resistance protein
JR441_RS07190	COG2076	Multidrug Resistance protein
JR441_RS07195	COG0788	formyltetrahydrofolate deformylase activity
JR441_RS07200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JR441_RS07205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JR441_RS07210	COG1764	response to oxidative stress
JR441_RS07215	COG1846	Transcriptional regulator
JR441_RS07220	COG1764	response to oxidative stress
JR441_RS07225	COG0590	tRNA wobble adenosine to inosine editing
JR441_RS07230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JR441_RS07235	COG1404	Belongs to the peptidase S8 family
JR441_RS07240	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_RS07245	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JR441_RS07250	COG1122	ATPase activity
JR441_RS07255	COG4721	ABC-type cobalt transport system, permease component
JR441_RS07265	COG0745	RESPONSE REGULATOR receiver
JR441_RS07270	COG3850	Histidine kinase
JR441_RS07270	COG5002	protein histidine kinase activity
JR441_RS07275	COG3212	peptidase
JR441_RS07280	COG3212	peptidase
JR441_RS07290	COG2239	Acts as a magnesium transporter
JR441_RS07295	COG0789	Transcriptional regulator
JR441_RS07310	COG1846	Transcriptional regulator
JR441_RS07315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JR441_RS07320	COG0726	polysaccharide deacetylase
JR441_RS07325	COG1408	metallophosphoesterase
JR441_RS07335	COG0463	Glycosyl transferase, family 2
JR441_RS07340	COG1793	dna ligase
JR441_RS07340	COG3285	dna ligase
JR441_RS07345	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
JR441_RS07355	COG0586	Pfam SNARE associated Golgi protein
JR441_RS07360	COG0861	Integral membrane protein TerC family
JR441_RS07365	COG1191	sigma factor activity
JR441_RS07385	COG0501	Belongs to the peptidase M48B family
JR441_RS07390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JR441_RS07405	COG3594	Acyltransferase
JR441_RS07410	COG5002	protein histidine kinase activity
JR441_RS07415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JR441_RS07425	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JR441_RS07430	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
JR441_RS07435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JR441_RS07440	COG0436	Aminotransferase
JR441_RS07445	COG1850	ribulose-bisphosphate carboxylase activity
JR441_RS07450	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
JR441_RS07455	COG0235	Class ii aldolase
JR441_RS07460	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
JR441_RS07465	COG3339	Conserved Protein
JR441_RS07480	COG3852	Histidine kinase
JR441_RS07485	COG1846	Transcriptional regulator
JR441_RS07490	COG1360	Flagellar Motor Protein
JR441_RS07495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JR441_RS07500	COG0542	response to heat
JR441_RS07505	COG3949	Membrane
JR441_RS07510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JR441_RS07515	COG0720	synthase
JR441_RS07520	COG0602	queuosine metabolic process
JR441_RS07525	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JR441_RS07535	COG1733	regulation of RNA biosynthetic process
JR441_RS07540	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS07545	COG4641	Protein conserved in bacteria
JR441_RS07545	COG1388	LysM domain
JR441_RS07550	COG1388	LysM domain
JR441_RS07555	COG3858	chitin binding
JR441_RS07565	COG4873	Protein conserved in bacteria
JR441_RS07575	COG3773	Cell wall hydrolase
JR441_RS07580	COG2244	polysaccharide biosynthetic process
JR441_RS07585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_RS07590	COG2217	Heavy metal translocating P-type atpase
JR441_RS07600	COG0006	proline dipeptidase activity
JR441_RS07605	COG1609	Transcriptional regulator
JR441_RS07610	COG3711	transcriptional antiterminator
JR441_RS07615	COG1263	PTS System
JR441_RS07615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS07615	COG2190	(PTS) system
JR441_RS07620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_RS07625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JR441_RS07635	COG1533	DNA photolyase activity
JR441_RS07640	COG0456	acetyltransferase
JR441_RS07645	COG0840	transmembrane signaling receptor activity
JR441_RS07650	COG2084	Dehydrogenase
JR441_RS07655	COG2340	Cysteine-rich secretory protein family
JR441_RS07660	COG0768	penicillin binding
JR441_RS07665	COG4191	Histidine kinase
JR441_RS07670	COG0436	Aminotransferase
JR441_RS07680	COG0835	chemotaxis
JR441_RS07680	COG0784	Response regulator, receiver
JR441_RS07690	COG2814	Major facilitator Superfamily
JR441_RS07695	COG1376	ErfK ybiS ycfS ynhG family protein
JR441_RS07700	COG1408	metallophosphoesterase
JR441_RS07705	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS07710	COG2200	EAL domain
JR441_RS07715	COG4703	Protein of unknown function (DUF1797)
JR441_RS07720	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
JR441_RS07730	COG0517	IMP dehydrogenase activity
JR441_RS07735	COG0583	DNA-binding transcription factor activity
JR441_RS07740	COG0716	FMN binding
JR441_RS07750	COG0716	FMN binding
JR441_RS07755	COG2171	N-acyltransferase activity
JR441_RS07760	COG1473	amidohydrolase
JR441_RS07770	COG0668	transmembrane transport
JR441_RS07775	COG0450	alkyl hydroperoxide reductase
JR441_RS07780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_RS07795	COG0746	molybdenum cofactor guanylyltransferase activity
JR441_RS07800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JR441_RS07805	COG0303	'Molybdopterin
JR441_RS07810	COG1763	Mo-molybdopterin cofactor biosynthetic process
JR441_RS07815	COG0314	molybdopterin synthase activity
JR441_RS07820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JR441_RS07825	COG1132	(ABC) transporter
JR441_RS07830	COG1132	(ABC) transporter
JR441_RS07840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JR441_RS07845	COG1136	(ABC) transporter
JR441_RS07850	COG0577	efflux transmembrane transporter activity
JR441_RS07855	COG1349	DNA-binding transcription factor activity
JR441_RS07860	COG1105	Belongs to the carbohydrate kinase PfkB family
JR441_RS07865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR441_RS07865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR441_RS07865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_RS07870	COG0681	Belongs to the peptidase S26 family
JR441_RS07880	COG0488	(ABC) transporter
JR441_RS07885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JR441_RS07890	COG2309	aminopeptidase activity
JR441_RS07900	COG1077	Cell shape determining protein MreB Mrl
JR441_RS07905	COG2002	toxin-antitoxin pair type II binding
JR441_RS07910	COG3852	Histidine kinase
JR441_RS07915	COG2105	PFAM AIG2 family protein
JR441_RS07915	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
JR441_RS07920	COG0569	domain protein
JR441_RS07925	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JR441_RS07930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JR441_RS07935	COG5503	Protein of unknown function (DUF1447)
JR441_RS07940	COG0561	phosphatase activity
JR441_RS07945	COG0242	peptide deformylase activity
JR441_RS07955	COG0497	DNA recombination
JR441_RS07960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JR441_RS07965	COG0022	dehydrogenase e1 component
JR441_RS07970	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR441_RS07975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JR441_RS07980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_RS07990	COG1982	Orn Lys Arg decarboxylase major
JR441_RS07995	COG4476	Belongs to the UPF0223 family
JR441_RS08000	COG4493	Belongs to the UPF0637 family
JR441_RS08010	COG0483	inositol monophosphate 1-phosphatase activity
JR441_RS08020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JR441_RS08040	COG1595	DNA-templated transcription, initiation
JR441_RS08060	COG1217	gtp-binding protein TYPA
JR441_RS08070	COG4896	Protein conserved in bacteria
JR441_RS08080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JR441_RS08085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JR441_RS08090	COG2066	Belongs to the glutaminase family
JR441_RS08095	COG4838	Belongs to the UPF0358 family
JR441_RS08100	COG0772	Belongs to the SEDS family
JR441_RS08105	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JR441_RS08110	COG1612	heme a metabolic process
JR441_RS08115	COG0109	protoheme IX farnesyltransferase activity
JR441_RS08120	COG2010	Cytochrome c
JR441_RS08120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JR441_RS08125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JR441_RS08130	COG1845	cytochrome c oxidase, subunit III
JR441_RS08135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JR441_RS08140	COG3336	cytochrome c oxidase
JR441_RS08150	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
JR441_RS08155	COG2340	Cysteine-rich secretory protein family
JR441_RS08170	COG3679	Belongs to the UPF0342 family
JR441_RS08175	COG4471	UPF0298 protein
JR441_RS08180	COG0742	ribosomal rna small subunit methyltransferase
JR441_RS08185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JR441_RS08190	COG3314	Sporulation integral membrane protein YlbJ
JR441_RS08195	COG1752	Esterase of the alpha-beta hydrolase superfamily
JR441_RS08200	COG3480	Lon protease (S16) C-terminal proteolytic domain
JR441_RS08205	COG1323	Belongs to the UPF0348 family
JR441_RS08215	COG1399	metal-binding, possibly nucleic acid-binding protein
JR441_RS08230	COG0454	-acetyltransferase
JR441_RS08235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JR441_RS08240	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JR441_RS08245	COG2001	Belongs to the MraZ family
JR441_RS08250	COG0275	rRNA processing
JR441_RS08255	COG4839	cell division protein FtsL
JR441_RS08260	COG0768	penicillin binding
JR441_RS08265	COG0768	penicillin binding
JR441_RS08270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JR441_RS08275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JR441_RS08280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JR441_RS08285	COG0772	Belongs to the SEDS family
JR441_RS08290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JR441_RS08295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JR441_RS08300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JR441_RS08305	COG3879	Bacterial protein of unknown function (DUF881)
JR441_RS08310	COG3879	Bacterial protein of unknown function (DUF881)
JR441_RS08315	COG3856	small basic protein
JR441_RS08320	COG0849	cell division
JR441_RS08325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JR441_RS08330	COG1404	Belongs to the peptidase S8 family
JR441_RS08330	COG4412	M6 family metalloprotease domain protein
JR441_RS08340	COG1191	sigma factor activity
JR441_RS08345	COG1191	sigma factor activity
JR441_RS08350	COG1119	ATPase activity
JR441_RS08355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR441_RS08360	COG1873	PFAM PRC-barrel domain
JR441_RS08365	COG1496	oxidoreductase activity
JR441_RS08370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JR441_RS08375	COG1799	cell septum assembly
JR441_RS08380	COG0762	integral membrane protein
JR441_RS08385	COG2302	S4 RNA-binding domain
JR441_RS08390	COG3599	regulation of cell shape
JR441_RS08395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JR441_RS08400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JR441_RS08405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JR441_RS08410	COG0564	pseudouridine synthase activity
JR441_RS08415	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JR441_RS08420	COG2233	PERMEase
JR441_RS08425	COG0540	Belongs to the ATCase OTCase family
JR441_RS08430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JR441_RS08435	COG0505	Belongs to the CarA family
JR441_RS08440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JR441_RS08445	COG0543	2 iron, 2 sulfur cluster binding
JR441_RS08450	COG0167	dihydroorotate dehydrogenase activity
JR441_RS08455	COG0284	orotidine-5'-phosphate decarboxylase activity
JR441_RS08460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JR441_RS08465	COG0175	sulfate reduction
JR441_RS08470	COG0306	phosphate transporter
JR441_RS08475	COG2046	Belongs to the sulfate adenylyltransferase family
JR441_RS08480	COG0529	Catalyzes the synthesis of activated sulfate
JR441_RS08485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JR441_RS08490	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
JR441_RS08495	COG1648	precorrin-2 dehydrogenase activity
JR441_RS08500	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JR441_RS08505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JR441_RS08510	COG1561	YicC-like family, N-terminal region
JR441_RS08520	COG0194	GDP metabolic process
JR441_RS08525	COG1758	RNA polymerase activity
JR441_RS08530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JR441_RS08535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JR441_RS08540	COG0242	peptide deformylase activity
JR441_RS08545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JR441_RS08550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JR441_RS08550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JR441_RS08555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JR441_RS08560	COG0631	protein serine/threonine phosphatase activity
JR441_RS08565	COG2815	serine threonine protein kinase
JR441_RS08565	COG0515	serine threonine protein kinase
JR441_RS08570	COG1162	GTPase activity
JR441_RS08575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JR441_RS08580	COG1564	THIamine pyrophosphokinase
JR441_RS08590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JR441_RS08595	COG1302	Protein conserved in bacteria
JR441_RS08600	COG1461	Dihydroxyacetone kinase
JR441_RS08605	COG1760	l-serine dehydratase
JR441_RS08610	COG1760	l-serine dehydratase
JR441_RS08615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JR441_RS08620	COG2050	protein possibly involved in aromatic compounds catabolism
JR441_RS08620	COG1349	DNA-binding transcription factor activity
JR441_RS08625	COG0416	fatty acid biosynthetic process
JR441_RS08630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JR441_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS08645	COG0571	ribonuclease III activity
JR441_RS08650	COG1196	nuclear chromosome segregation
JR441_RS08655	COG0552	protein localization to endoplasmic reticulum
JR441_RS08665	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JR441_RS08670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JR441_RS08675	COG0228	four-way junction DNA binding
JR441_RS08680	COG1837	Belongs to the UPF0109 family
JR441_RS08690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JR441_RS08695	COG0336	Belongs to the RNA methyltransferase TrmD family
JR441_RS08700	COG0335	large ribosomal subunit rRNA binding
JR441_RS08705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JR441_RS08710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JR441_RS08720	COG2257	FlhB HrpN YscU SpaS Family
JR441_RS08725	COG0045	succinate-CoA ligase (ADP-forming) activity
JR441_RS08730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JR441_RS08735	COG0758	DNA mediated transformation
JR441_RS08740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JR441_RS08745	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JR441_RS08750	COG4974	Belongs to the 'phage' integrase family
JR441_RS08755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JR441_RS08760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JR441_RS08765	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JR441_RS08770	COG1815	bacterial-type flagellum-dependent cell motility
JR441_RS08775	COG1558	bacterial-type flagellum-dependent cell motility
JR441_RS08780	COG1677	Flagellar hook-basal body complex protein FliE
JR441_RS08785	COG1766	The M ring may be actively involved in energy transduction
JR441_RS08790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JR441_RS08795	COG1317	bacterial-type flagellum organization
JR441_RS08800	COG1157	protein secretion by the type III secretion system
JR441_RS08805	COG2882	bacterial-type flagellum organization
JR441_RS08810	COG3334	PFAM MgtE intracellular
JR441_RS08815	COG3144	bacterial-type flagellum assembly
JR441_RS08820	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JR441_RS08825	COG4786	Flagellar basal body rod
JR441_RS08830	COG1582	Flagellar protein (FlbD)
JR441_RS08835	COG1580	Controls the rotational direction of flagella during chemotaxis
JR441_RS08840	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JR441_RS08845	COG1776	CheC inhibitor of MCP methylation
JR441_RS08845	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JR441_RS08850	COG2201	protein-glutamate methylesterase activity
JR441_RS08855	COG3190	flagellar
JR441_RS08860	COG1338	Plays a role in the flagellum-specific transport system
JR441_RS08865	COG1987	bacterial-type flagellum assembly
JR441_RS08870	COG1684	flagellar biosynthetic protein fliR
JR441_RS08875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JR441_RS08880	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JR441_RS08885	COG1419	protein localization to endoplasmic reticulum
JR441_RS08890	COG0455	bacterial-type flagellum organization
JR441_RS08895	COG2201	protein-glutamate methylesterase activity
JR441_RS08900	COG2198	Histidine kinase
JR441_RS08900	COG0643	Histidine kinase
JR441_RS08905	COG0835	chemotaxis
JR441_RS08910	COG1776	CheC inhibitor of MCP methylation
JR441_RS08915	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
JR441_RS08920	COG1191	sigma factor activity
JR441_RS08930	COG0052	Belongs to the universal ribosomal protein uS2 family
JR441_RS08935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JR441_RS08940	COG0528	UMP kinase activity
JR441_RS08945	COG0233	cytoplasmic translational termination
JR441_RS08950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JR441_RS08955	COG4589	Belongs to the CDS family
JR441_RS08960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JR441_RS08965	COG0750	zinc metalloprotease
JR441_RS08970	COG0442	prolyl-tRNA aminoacylation
JR441_RS08975	COG2176	DNA-directed DNA polymerase activity
JR441_RS08980	COG0779	Required for maturation of 30S ribosomal subunits
JR441_RS08985	COG0195	Participates in both transcription termination and antitermination
JR441_RS08990	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JR441_RS08995	COG1358	cellular component organization or biogenesis
JR441_RS09000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JR441_RS09005	COG1550	Protein conserved in bacteria
JR441_RS09010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JR441_RS09015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JR441_RS09020	COG0196	riboflavin kinase activity
JR441_RS09025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JR441_RS09030	COG1185	polyribonucleotide nucleotidyltransferase activity
JR441_RS09035	COG0726	polysaccharide deacetylase
JR441_RS09040	COG0612	Peptidase, M16
JR441_RS09045	COG1873	PFAM PRC-barrel domain
JR441_RS09050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JR441_RS09055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JR441_RS09060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JR441_RS09065	COG0527	aspartate kinase activity
JR441_RS09070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JR441_RS09075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JR441_RS09080	COG0740	serine-type endopeptidase activity
JR441_RS09090	COG1674	ftsk spoiiie
JR441_RS09090	COG4980	gas vesicle protein
JR441_RS09095	COG2188	Transcriptional regulator
JR441_RS09100	COG2814	Major facilitator Superfamily
JR441_RS09105	COG0612	Peptidase, M16
JR441_RS09110	COG0612	Peptidase, M16
JR441_RS09115	COG0300	oxidoreductase activity
JR441_RS09130	COG1426	Protein conserved in bacteria
JR441_RS09135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JR441_RS09140	COG1546	Belongs to the CinA family
JR441_RS09140	COG1058	Belongs to the CinA family
JR441_RS09145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JR441_RS09150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JR441_RS09155	COG1418	mRNA catabolic process
JR441_RS09160	COG1692	metallophosphoesterase
JR441_RS09165	COG2359	stage V sporulation protein S
JR441_RS09170	COG1063	alcohol dehydrogenase
JR441_RS09175	COG0156	8-amino-7-oxononanoate synthase activity
JR441_RS09180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JR441_RS09185	COG4550	Control of competence regulator ComK, YlbF/YmcA
JR441_RS09195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JR441_RS09200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JR441_RS09215	COG3226	Transcriptional regulator
JR441_RS09220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_RS09230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JR441_RS09235	COG3321	synthase
JR441_RS09240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JR441_RS09240	COG2070	2-Nitropropane dioxygenase
JR441_RS09245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_RS09250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JR441_RS09255	COG3425	synthase
JR441_RS09260	COG1024	Enoyl-CoA hydratase
JR441_RS09265	COG1024	Enoyl-CoA hydratase
JR441_RS09270	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_RS09270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS09270	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS09270	COG0300	oxidoreductase activity
JR441_RS09270	COG3321	synthase
JR441_RS09275	COG3321	synthase
JR441_RS09275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_RS09275	COG4221	oxidoreductase activity
JR441_RS09275	COG0300	oxidoreductase activity
JR441_RS09280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_RS09280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS09280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_RS09280	COG3321	synthase
JR441_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS09285	COG3321	synthase
JR441_RS09285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS09285	COG4221	oxidoreductase activity
JR441_RS09290	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JR441_RS09290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JR441_RS09290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_RS09290	COG3321	synthase
JR441_RS09295	COG2124	cytochrome p450
JR441_RS09305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_RS09310	COG1404	Belongs to the peptidase S8 family
JR441_RS09320	COG4195	phage-related replication protein
JR441_RS09325	COG1764	response to oxidative stress
JR441_RS09330	COG2076	Multidrug Resistance protein
JR441_RS09335	COG2076	Multidrug Resistance protein
JR441_RS09350	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JR441_RS09355	COG1923	regulation of RNA biosynthetic process
JR441_RS09370	COG1780	Probably involved in ribonucleotide reductase function
JR441_RS09375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JR441_RS09380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JR441_RS09385	COG4112	unkown
JR441_RS09390	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_RS09395	COG0464	growth
JR441_RS09400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JR441_RS09405	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JR441_RS09410	COG0789	Transcriptional regulator
JR441_RS09415	COG0174	glutamine synthetase
JR441_RS09430	COG5444	nuclease activity
JR441_RS09435	COG5444	nuclease activity
JR441_RS09455	COG0463	Glycosyl transferase, family 2
JR441_RS09465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_RS09480	COG3655	Transcriptional regulator
JR441_RS09510	COG2211	Major facilitator Superfamily
JR441_RS09515	COG3507	Belongs to the glycosyl hydrolase 43 family
JR441_RS09520	COG1940	carbohydrate kinase activity
JR441_RS09525	COG2115	Belongs to the xylose isomerase family
JR441_RS09530	COG1070	Carbohydrate kinase
JR441_RS09540	COG1525	nuclease
JR441_RS09545	COG2814	Major facilitator Superfamily
JR441_RS09550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JR441_RS09560	COG0756	dUTP diphosphatase activity
JR441_RS09575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JR441_RS09605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JR441_RS09615	COG3832	glyoxalase III activity
JR441_RS09630	COG0697	spore germination
JR441_RS09635	COG0531	amino acid
JR441_RS09665	COG4195	phage-related replication protein
JR441_RS09675	COG0346	lactoylglutathione lyase activity
JR441_RS09680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JR441_RS09685	COG1388	LysM domain
JR441_RS09690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JR441_RS09695	COG4224	UPF0291 protein
JR441_RS09700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JR441_RS09710	COG3763	UPF0154 protein
JR441_RS09720	COG0785	Cytochrome C biogenesis protein
JR441_RS09725	COG2201	protein-glutamate methylesterase activity
JR441_RS09730	COG4846	Membrane protein involved in cytochrome C biogenesis
JR441_RS09740	COG0071	Belongs to the small heat shock protein (HSP20) family
JR441_RS09755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JR441_RS09760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_RS09780	COG0824	Thioesterase
JR441_RS09790	COG4841	protein insertion into membrane
JR441_RS09795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JR441_RS09800	COG1832	CoA-binding protein
JR441_RS09805	COG0187	DNA topoisomerase II activity
JR441_RS09810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JR441_RS09820	COG1115	amino acid carrier protein
JR441_RS09825	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
JR441_RS09835	COG5520	Belongs to the glycosyl hydrolase 30 family
JR441_RS09840	COG3507	Belongs to the glycosyl hydrolase 43 family
JR441_RS09845	COG2246	polysaccharide biosynthetic process
JR441_RS09850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JR441_RS09855	COG0586	Pfam SNARE associated Golgi protein
JR441_RS09860	COG2404	hydrolase activity, acting on ester bonds
JR441_RS09865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JR441_RS09870	COG1024	Enoyl-CoA hydratase
JR441_RS09875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JR441_RS09880	COG0511	ligase activity, forming carbon-carbon bonds
JR441_RS09885	COG0439	Biotin carboxylase
JR441_RS09890	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_RS09895	COG1960	acyl-CoA dehydrogenase activity
JR441_RS09910	COG1649	PFAM Uncharacterised BCR, COG1649
JR441_RS09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS09920	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JR441_RS09925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS09940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS09945	COG2027	D-alanyl-D-alanine carboxypeptidase
JR441_RS09950	COG2017	converts alpha-aldose to the beta-anomer
JR441_RS09955	COG0534	Mate efflux family protein
JR441_RS09970	COG0582	viral genome integration into host DNA
JR441_RS09975	COG0166	Belongs to the GPI family
JR441_RS09980	COG0405	Gamma-glutamyltransferase
JR441_RS09985	COG0583	DNA-binding transcription factor activity
JR441_RS09990	COG0604	alcohol dehydrogenase
JR441_RS09995	COG0493	'glutamate synthase
JR441_RS10000	COG0067	glutamate synthase
JR441_RS10000	COG0069	glutamate synthase activity
JR441_RS10000	COG0070	glutamate synthase
JR441_RS10005	COG0583	DNA-binding transcription factor activity
JR441_RS10010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JR441_RS10015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JR441_RS10025	COG0300	oxidoreductase activity
JR441_RS10030	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JR441_RS10040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_RS10045	COG2814	Major facilitator Superfamily
JR441_RS10050	COG1070	Carbohydrate kinase
JR441_RS10055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JR441_RS10060	COG0243	molybdopterin cofactor binding
JR441_RS10090	COG0840	transmembrane signaling receptor activity
JR441_RS10090	COG5278	phosphoserine phosphatase activity
JR441_RS10095	COG2368	4-hydroxyphenylacetate
JR441_RS10100	COG4305	rare lipoprotein A
JR441_RS10105	COG3619	membrane
JR441_RS10110	COG3866	Pectate lyase
JR441_RS10115	COG2135	peptidase activity
JR441_RS10125	COG2140	Oxalate decarboxylase
JR441_RS10140	COG0456	acetyltransferase
JR441_RS10160	COG2720	vancomycin resistance protein
JR441_RS10170	COG3655	Transcriptional regulator
JR441_RS10175	COG3739	integral membrane protein
JR441_RS10180	COG0583	DNA-binding transcription factor activity
JR441_RS10185	COG0697	spore germination
JR441_RS10195	COG0693	protein deglycase activity
JR441_RS10200	COG2367	Beta-lactamase
JR441_RS10220	COG3848	Pyruvate phosphate dikinase
JR441_RS10220	COG0574	Belongs to the PEP-utilizing enzyme family
JR441_RS10225	COG0726	polysaccharide deacetylase
JR441_RS10275	COG2723	6-phospho-beta-galactosidase activity
JR441_RS10290	COG0395	ABC-type sugar transport system, permease component
JR441_RS10295	COG1175	transmembrane transport
JR441_RS10305	COG1940	carbohydrate kinase activity
JR441_RS10315	COG5444	nuclease activity
JR441_RS10320	COG4282	regulation of fungal-type cell wall biogenesis
JR441_RS10325	COG1231	oxidoreductase activity
JR441_RS10330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_RS10335	COG2207	Transcriptional regulator
JR441_RS10335	COG0662	Cupin 2, conserved barrel domain protein
JR441_RS10340	COG0456	acetyltransferase
JR441_RS10345	COG1309	transcriptional regulator
JR441_RS10350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_RS10355	COG3708	Transcriptional regulator
JR441_RS10360	COG2378	regulation of single-species biofilm formation
JR441_RS10370	COG0640	Transcriptional regulator
JR441_RS10375	COG0741	lytic transglycosylase activity
JR441_RS10380	COG2322	membrane
JR441_RS10400	COG3239	Fatty acid desaturase
JR441_RS10405	COG4585	Histidine kinase
JR441_RS10410	COG2197	response regulator
JR441_RS10415	COG3584	3D domain protein
JR441_RS10415	COG1388	LysM domain
JR441_RS10420	COG0514	ATP-dependent DNA helicase (RecQ)
JR441_RS10430	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JR441_RS10435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JR441_RS10450	COG0071	Belongs to the small heat shock protein (HSP20) family
JR441_RS10475	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS10480	COG1657	PFAM Prenyltransferase squalene oxidase
JR441_RS10485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JR441_RS10490	COG0733	neurotransmitter:sodium symporter activity
JR441_RS10495	COG0385	Bile acid
JR441_RS10500	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR441_RS10505	COG0567	Dehydrogenase, E1 component
JR441_RS10510	COG4548	von Willebrand factor, type A
JR441_RS10515	COG0714	Associated with various cellular activities
JR441_RS10520	COG2032	superoxide dismutase activity
JR441_RS10525	COG1388	LysM domain
JR441_RS10525	COG0791	NLP P60 protein
JR441_RS10530	COG1819	glycosyl
JR441_RS10535	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JR441_RS10540	COG0534	Mate efflux family protein
JR441_RS10545	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_RS10550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR441_RS10555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR441_RS10565	COG2962	Rard protein
JR441_RS10580	COG2610	gluconate transmembrane transporter activity
JR441_RS10585	COG1942	4-Oxalocrotonate Tautomerase
JR441_RS10590	COG1733	regulation of RNA biosynthetic process
JR441_RS10595	COG0778	Nitroreductase
JR441_RS10600	COG0400	carboxylic ester hydrolase activity
JR441_RS10605	COG0346	lactoylglutathione lyase activity
JR441_RS10615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_RS10620	COG3409	Peptidoglycan-binding domain 1 protein
JR441_RS10620	COG0793	Belongs to the peptidase S41A family
JR441_RS10625	COG2226	methyltransferase
JR441_RS10635	COG1876	peptidase activity
JR441_RS10640	COG0813	purine-nucleoside phosphorylase activity
JR441_RS10655	COG0671	phosphoesterase, PA-phosphatase related
JR441_RS10675	COG4479	Belongs to the UPF0346 family
JR441_RS10685	COG1509	lysine 2,3-aminomutase activity
JR441_RS10690	COG0456	acetyltransferase
JR441_RS10695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR441_RS10700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JR441_RS10705	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JR441_RS10710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JR441_RS10725	COG0456	acetyltransferase
JR441_RS10730	COG0463	Glycosyl transferase, family 2
JR441_RS10745	COG4641	Protein conserved in bacteria
JR441_RS10750	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
JR441_RS10755	COG1086	Polysaccharide biosynthesis protein
JR441_RS10760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JR441_RS10765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JR441_RS10770	COG1846	Transcriptional regulator
JR441_RS10775	COG0534	Mate efflux family protein
JR441_RS10785	COG4698	Protein conserved in bacteria
JR441_RS10790	COG2755	lipolytic protein G-D-S-L family
JR441_RS10795	COG1999	signal sequence binding
JR441_RS10805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JR441_RS10810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JR441_RS10815	COG1272	protein, Hemolysin III
JR441_RS10820	COG0204	Acyl-transferase
JR441_RS10825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JR441_RS10830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JR441_RS10835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JR441_RS10845	COG2136	Putative SAM-dependent methyltransferase
JR441_RS10845	COG2521	methyltransferase
JR441_RS10855	COG0129	dihydroxy-acid dehydratase activity
JR441_RS10860	COG1413	lyase activity
JR441_RS10865	COG1418	mRNA catabolic process
JR441_RS10870	COG0386	Belongs to the glutathione peroxidase family
JR441_RS10875	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JR441_RS10880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JR441_RS10890	COG1278	Cold shock
JR441_RS10910	COG0328	RNA-DNA hybrid ribonuclease activity
JR441_RS10915	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JR441_RS10920	COG0328	RNA-DNA hybrid ribonuclease activity
JR441_RS10930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JR441_RS10945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JR441_RS10955	COG1755	Isoprenylcysteine carboxyl methyltransferase
JR441_RS10960	COG3424	synthase
JR441_RS10965	COG2233	PERMEase
JR441_RS10970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JR441_RS10975	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JR441_RS10985	COG0800	Aldolase
JR441_RS10990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_RS10995	COG1609	Transcriptional regulator
JR441_RS11000	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
JR441_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS11010	COG1199	ATP-dependent helicase activity
JR441_RS11025	COG0116	Belongs to the methyltransferase superfamily
JR441_RS11040	COG4474	Belongs to the UPF0398 family
JR441_RS11055	COG3359	exonuclease
JR441_RS11060	COG1205	dead DEAH box helicase
JR441_RS11060	COG1111	helicase
JR441_RS11065	COG2190	(PTS) system
JR441_RS11070	COG0071	Belongs to the small heat shock protein (HSP20) family
JR441_RS11105	COG3331	DNA recombination
JR441_RS11110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JR441_RS11110	COG4499	WXG100 protein secretion system (Wss), protein YukC
JR441_RS11120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JR441_RS11125	COG3935	DnaD domain protein
JR441_RS11130	COG0017	Asparaginyl-tRNA synthetase
JR441_RS11135	COG0436	Aminotransferase
JR441_RS11140	COG5353	protein conserved in bacteria
JR441_RS11150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JR441_RS11150	COG1199	ATP-dependent helicase activity
JR441_RS11155	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JR441_RS11160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JR441_RS11165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JR441_RS11170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JR441_RS11170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JR441_RS11175	COG0617	tRNA 3'-terminal CCA addition
JR441_RS11180	COG0438	transferase activity, transferring glycosyl groups
JR441_RS11185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR441_RS11190	COG1803	Methylglyoxal synthase
JR441_RS11195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JR441_RS11200	COG1694	Mazg nucleotide pyrophosphohydrolase
JR441_RS11205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_RS11215	COG4347	Protein of unknown function (DUF1405)
JR441_RS11220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JR441_RS11220	COG2010	Cytochrome c
JR441_RS11225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JR441_RS11230	COG0723	plastoquinol--plastocyanin reductase activity
JR441_RS11240	COG5582	Belongs to the UPF0302 family
JR441_RS11245	COG0457	Tetratricopeptide repeat
JR441_RS11250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JR441_RS11255	COG0287	Prephenate dehydrogenase
JR441_RS11265	COG0159	tryptophan synthase activity
JR441_RS11270	COG0133	tryptophan synthase activity
JR441_RS11275	COG0135	phosphoribosylanthranilate isomerase activity
JR441_RS11285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JR441_RS11290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JR441_RS11295	COG4401	Chorismate mutase type I
JR441_RS11300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JR441_RS11305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JR441_RS11310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JR441_RS11315	COG0105	UTP biosynthetic process
JR441_RS11320	COG0142	geranyltranstransferase activity
JR441_RS11325	COG2226	methyltransferase
JR441_RS11330	COG0142	geranyltranstransferase activity
JR441_RS11340	COG0302	gtp cyclohydrolase
JR441_RS11345	COG0776	regulation of translation
JR441_RS11350	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JR441_RS11365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JR441_RS11370	COG1160	GTP binding
JR441_RS11395	COG1304	FMN binding
JR441_RS11400	COG0539	negative regulation of cytoplasmic translation
JR441_RS11405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JR441_RS11415	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
JR441_RS11420	COG2959	enzyme of heme biosynthesis
JR441_RS11425	COG3409	Peptidoglycan-binding domain 1 protein
JR441_RS11425	COG3773	Cell wall hydrolase
JR441_RS11430	COG2339	peptidase activity
JR441_RS11435	COG0492	ferredoxin-NADP+ reductase activity
JR441_RS11440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JR441_RS11445	COG4862	establishment of competence for transformation
JR441_RS11450	COG1408	metallophosphoesterase
JR441_RS11460	COG1388	LysM domain
JR441_RS11465	COG1266	CAAX protease self-immunity
JR441_RS11470	COG0514	ATP-dependent DNA helicase (RecQ)
JR441_RS11475	COG4955	Helix-turn-helix domain
JR441_RS11480	COG1141	Ferredoxin
JR441_RS11485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JR441_RS11490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JR441_RS11495	COG0710	3-dehydroquinate dehydratase activity
JR441_RS11505	COG1595	DNA-templated transcription, initiation
JR441_RS11510	COG5002	protein histidine kinase activity
JR441_RS11515	COG0745	RESPONSE REGULATOR receiver
JR441_RS11520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JR441_RS11525	COG1333	cytochrome c biogenesis protein
JR441_RS11530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_RS11535	COG1187	pseudouridine synthase activity
JR441_RS11540	COG0700	Nucleoside recognition
JR441_RS11545	COG2715	membrane protein required for spore maturation
JR441_RS11550	COG1686	Belongs to the peptidase S11 family
JR441_RS11560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JR441_RS11565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JR441_RS11570	COG1547	Domain of unknown function (DUF309)
JR441_RS11575	COG0456	acetyltransferase
JR441_RS11580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JR441_RS11585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JR441_RS11585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JR441_RS11590	COG0307	riboflavin synthase, alpha
JR441_RS11595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JR441_RS11595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JR441_RS11605	COG0681	Belongs to the peptidase S26 family
JR441_RS11615	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
JR441_RS11640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JR441_RS11645	COG4086	secreted protein
JR441_RS11650	COG0019	diaminopimelate decarboxylase activity
JR441_RS11655	COG0697	spore germination
JR441_RS11670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JR441_RS11690	COG1191	sigma factor activity
JR441_RS11695	COG2172	sigma factor antagonist activity
JR441_RS11700	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_RS11705	COG1686	Belongs to the peptidase S11 family
JR441_RS11710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JR441_RS11715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JR441_RS11720	COG4974	Belongs to the 'phage' integrase family
JR441_RS11730	COG0735	belongs to the Fur family
JR441_RS11735	COG1300	Membrane
JR441_RS11745	COG0281	malic enzyme
JR441_RS11750	COG1757	Na H antiporter
JR441_RS11755	COG1027	Aspartate ammonia-lyase
JR441_RS11760	COG0252	asparaginase activity
JR441_RS11765	COG1396	sequence-specific DNA binding
JR441_RS11770	COG1379	DNA repair
JR441_RS11775	COG0494	nUDIX hydrolase
JR441_RS11785	COG0667	Aldo Keto reductase
JR441_RS11795	COG1073	alpha beta
JR441_RS11805	COG4918	Iron-sulphur cluster biosynthesis
JR441_RS11810	COG0456	acetyltransferase
JR441_RS11810	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JR441_RS11815	COG2329	Antibiotic biosynthesis monooxygenase
JR441_RS11820	COG0456	acetyltransferase
JR441_RS11830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JR441_RS11840	COG2211	Major facilitator Superfamily
JR441_RS11850	COG0346	lactoylglutathione lyase activity
JR441_RS11855	COG1072	(Pantothenic acid kinase))
JR441_RS11860	COG3048	D-serine ammonia-lyase activity
JR441_RS11865	COG0300	oxidoreductase activity
JR441_RS11870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_RS11875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JR441_RS11880	COG4187	Peptidase family M20/M25/M40
JR441_RS11885	COG1902	pentaerythritol trinitrate reductase activity
JR441_RS11890	COG0596	Alpha beta hydrolase
JR441_RS11900	COG1234	tRNA 3'-trailer cleavage
JR441_RS11905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JR441_RS11910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JR441_RS11915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JR441_RS11925	COG0706	membrane insertase activity
JR441_RS11930	COG3361	conserved protein (COG2071)
JR441_RS11935	COG2195	Cleaves the N-terminal amino acid of tripeptides
JR441_RS11940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JR441_RS11945	COG0346	lactoylglutathione lyase activity
JR441_RS11955	COG1376	ErfK ybiS ycfS ynhG family protein
JR441_RS11960	COG4129	membrane
JR441_RS11965	COG1126	abc transporter atp-binding protein
JR441_RS11970	COG0765	amino acid transport
JR441_RS11975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_RS11985	COG1597	lipid kinase activity
JR441_RS11990	COG2814	Major facilitator Superfamily
JR441_RS11995	COG4978	Transcriptional regulator
JR441_RS11995	COG0789	Transcriptional regulator
JR441_RS12000	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR441_RS12005	COG0022	dehydrogenase e1 component
JR441_RS12010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JR441_RS12015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JR441_RS12020	COG3426	butyrate kinase activity
JR441_RS12025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JR441_RS12030	COG0280	phosphate acetyltransferase
JR441_RS12035	COG3829	transcription factor binding
JR441_RS12035	COG3290	protein histidine kinase activity
JR441_RS12045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JR441_RS12050	COG2079	MmgE PrpD family protein
JR441_RS12055	COG0372	Belongs to the citrate synthase family
JR441_RS12060	COG1960	acyl-CoA dehydrogenase activity
JR441_RS12065	COG1250	3-hydroxyacyl-CoA dehydrogenase
JR441_RS12070	COG0183	Belongs to the thiolase family
JR441_RS12075	COG0584	glycerophosphoryl diester phosphodiesterase
JR441_RS12080	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_RS12095	COG1902	pentaerythritol trinitrate reductase activity
JR441_RS12100	COG0745	RESPONSE REGULATOR receiver
JR441_RS12105	COG0750	zinc metalloprotease
JR441_RS12110	COG0497	DNA recombination
JR441_RS12115	COG1438	arginine binding
JR441_RS12120	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
JR441_RS12125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JR441_RS12130	COG0142	geranyltranstransferase activity
JR441_RS12135	COG1722	exodeoxyribonuclease VII activity
JR441_RS12140	COG1570	exodeoxyribonuclease VII activity
JR441_RS12145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JR441_RS12150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JR441_RS12155	COG1302	Protein conserved in bacteria
JR441_RS12160	COG0439	Biotin carboxylase
JR441_RS12165	COG0511	ligase activity, forming carbon-carbon bonds
JR441_RS12205	COG3854	ATPases associated with a variety of cellular activities
JR441_RS12215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JR441_RS12220	COG0006	proline dipeptidase activity
JR441_RS12225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JR441_RS12235	COG3872	metal-dependent enzyme
JR441_RS12245	COG1752	Esterase of the alpha-beta hydrolase superfamily
JR441_RS12250	COG1321	iron dependent repressor
JR441_RS12255	COG0095	Lipoate-protein ligase
JR441_RS12260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JR441_RS12265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JR441_RS12270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JR441_RS12275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JR441_RS12280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JR441_RS12295	COG1396	sequence-specific DNA binding
JR441_RS12305	COG0681	Belongs to the peptidase S26 family
JR441_RS12330	COG4940	Competence protein ComGF
JR441_RS12340	COG4970	Tfp pilus assembly protein FimT
JR441_RS12345	COG4537	Required for transformation and DNA binding
JR441_RS12350	COG1459	type II secretion system
JR441_RS12355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JR441_RS12360	COG0517	IMP dehydrogenase activity
JR441_RS12365	COG0598	Magnesium transport protein CorA
JR441_RS12370	COG1253	flavin adenine dinucleotide binding
JR441_RS12375	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_RS12385	COG1393	Belongs to the ArsC family
JR441_RS12395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_RS12405	COG0011	TIGRFAM Protein of
JR441_RS12415	COG2866	Carboxypeptidase
JR441_RS12420	COG1368	sulfuric ester hydrolase activity
JR441_RS12425	COG1940	carbohydrate kinase activity
JR441_RS12430	COG4483	Protein conserved in bacteria
JR441_RS12435	COG0457	Tetratricopeptide repeat
JR441_RS12435	COG0705	Rhomboid family
JR441_RS12445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JR441_RS12455	COG0438	transferase activity, transferring glycosyl groups
JR441_RS12470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JR441_RS12475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JR441_RS12480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JR441_RS12485	COG0581	inorganic phosphate transmembrane transporter activity
JR441_RS12490	COG0573	inorganic phosphate transmembrane transporter activity
JR441_RS12495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JR441_RS12500	COG0768	penicillin binding
JR441_RS12505	COG0477	Major facilitator Superfamily
JR441_RS12510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JR441_RS12515	COG2839	Protein conserved in bacteria
JR441_RS12520	COG5521	maltodextrose utilization protein MalA
JR441_RS12525	COG1388	LysM domain
JR441_RS12530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JR441_RS12535	COG4709	membrane
JR441_RS12540	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
JR441_RS12545	COG0735	belongs to the Fur family
JR441_RS12550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_RS12560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JR441_RS12565	COG0513	Belongs to the DEAD box helicase family
JR441_RS12575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JR441_RS12580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JR441_RS12585	COG2384	SAM-dependent methyltransferase
JR441_RS12590	COG2010	Cytochrome c
JR441_RS12595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JR441_RS12600	COG0358	DNA primase activity
JR441_RS12605	COG1671	Belongs to the UPF0178 family
JR441_RS12610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JR441_RS12615	COG0517	IMP dehydrogenase activity
JR441_RS12620	COG0751	glycine-tRNA ligase activity
JR441_RS12625	COG0752	glycyl-tRNA synthetase alpha subunit
JR441_RS12630	COG1381	Involved in DNA repair and RecF pathway recombination
JR441_RS12640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JR441_RS12645	COG0295	cytidine deaminase activity
JR441_RS12650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JR441_RS12655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JR441_RS12660	COG1480	7TM receptor with intracellular HD hydrolase
JR441_RS12665	COG1702	phosphate starvation-inducible protein PhoH
JR441_RS12670	COG0561	phosphatase activity
JR441_RS12685	COG4864	UPF0365 protein
JR441_RS12690	COG1030	water channel activity
JR441_RS12695	COG1610	YqeY-like protein
JR441_RS12705	COG1283	sodium-dependent phosphate transmembrane transporter activity
JR441_RS12710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JR441_RS12715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JR441_RS12720	COG2264	protein methyltransferase activity
JR441_RS12725	COG0484	heat shock protein binding
JR441_RS12730	COG0443	Heat shock 70 kDa protein
JR441_RS12735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JR441_RS12740	COG1420	regulation of RNA biosynthetic process
JR441_RS12745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JR441_RS12750	COG0481	GTPase activity
JR441_RS12760	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_RS12765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
JR441_RS12770	COG0268	Binds directly to 16S ribosomal RNA
JR441_RS12775	COG1466	dna polymerase III delta subunit
JR441_RS12790	COG0658	competence protein
JR441_RS12790	COG2333	competence protein COMEC
JR441_RS12795	COG2131	deaminase
JR441_RS12800	COG1555	photosystem II stabilization
JR441_RS12800	COG1596	polysaccharide export
JR441_RS12805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JR441_RS12810	COG2226	methyltransferase
JR441_RS12815	COG0799	negative regulation of ribosome biogenesis
JR441_RS12820	COG1713	HD superfamily hydrolase involved in NAD metabolism
JR441_RS12825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JR441_RS12830	COG1534	Rna-binding protein
JR441_RS12835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JR441_RS12840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JR441_RS12845	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JR441_RS12855	COG2755	lipolytic protein G-D-S-L family
JR441_RS12860	COG3409	Peptidoglycan-binding domain 1 protein
JR441_RS12860	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_RS12865	COG0398	Pfam SNARE associated Golgi protein
JR441_RS12870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JR441_RS12880	COG3209	COG3209 Rhs family protein
JR441_RS12890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JR441_RS12895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JR441_RS12900	COG0798	PFAM Bile acid sodium symporter
JR441_RS12905	COG0346	lactoylglutathione lyase activity
JR441_RS12910	COG0640	Transcriptional regulator
JR441_RS12915	COG3403	YqcI/YcgG family
JR441_RS12935	COG0604	alcohol dehydrogenase
JR441_RS12960	COG0457	Tetratricopeptide repeat
JR441_RS12975	COG5444	nuclease activity
JR441_RS13000	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_RS13000	COG3409	Peptidoglycan-binding domain 1 protein
JR441_RS13005	COG4824	toxin secretion phage lysis holin
JR441_RS13035	COG3778	Protein conserved in bacteria
JR441_RS13040	COG3299	homolog of phage Mu protein gp47
JR441_RS13045	COG3628	GPW Gp25 family protein
JR441_RS13055	COG4193	domain, Protein
JR441_RS13060	COG1652	LysM domain
JR441_RS13065	COG3953	SLT domain
JR441_RS13065	COG5280	Phage tail tape measure protein TP901
JR441_RS13120	COG4653	Phage capsid family
JR441_RS13125	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JR441_RS13135	COG2369	cell adhesion
JR441_RS13140	COG5518	Phage portal protein
JR441_RS13145	COG1783	phage Terminase large subunit
JR441_RS13150	COG5484	DNA packaging
JR441_RS13160	COG3677	Transposase
JR441_RS13175	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
JR441_RS13185	COG1484	DNA-dependent DNA replication
JR441_RS13190	COG3935	DnaD domain protein
JR441_RS13195	COG3723	Recombinational DNA repair protein, rece pathway
JR441_RS13200	COG5377	YqaJ viral recombinase family
JR441_RS13230	COG1476	TRANSCRIPTIONal
JR441_RS13235	COG3620	sequence-specific DNA binding
JR441_RS13245	COG0563	adenylate kinase activity
JR441_RS13250	COG2856	Zn peptidase
JR441_RS13270	COG4124	Belongs to the glycosyl hydrolase 26 family
JR441_RS13275	COG0730	response to heat
JR441_RS13280	COG0425	Belongs to the sulfur carrier protein TusA family
JR441_RS13285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JR441_RS13285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_RS13295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JR441_RS13295	COG0425	Belongs to the sulfur carrier protein TusA family
JR441_RS13300	COG2210	Belongs to the sulfur carrier protein TusA family
JR441_RS13305	COG1937	Protein conserved in bacteria
JR441_RS13310	COG0662	Cupin 2, conserved barrel domain protein
JR441_RS13320	COG4978	Transcriptional regulator
JR441_RS13320	COG0789	Transcriptional regulator
JR441_RS13325	COG2814	Major facilitator Superfamily
JR441_RS13335	COG1253	flavin adenine dinucleotide binding
JR441_RS13345	COG0697	spore germination
JR441_RS13350	COG0583	DNA-binding transcription factor activity
JR441_RS13355	COG2072	flavoprotein involved in K transport
JR441_RS13360	COG1230	cation diffusion facilitator family transporter
JR441_RS13365	COG1942	4-Oxalocrotonate Tautomerase
JR441_RS13370	COG0583	DNA-binding transcription factor activity
JR441_RS13380	COG1114	Component of the transport system for branched-chain amino acids
JR441_RS13385	COG1687	branched-chain amino acid
JR441_RS13390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JR441_RS13395	COG1522	sequence-specific DNA binding
JR441_RS13405	COG2124	cytochrome p450
JR441_RS13415	COG1335	isochorismatase
JR441_RS13430	COG2318	DinB family
JR441_RS13440	COG2070	2-Nitropropane dioxygenase
JR441_RS13445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JR441_RS13465	COG3443	Belongs to the bacterial solute-binding protein 9 family
JR441_RS13470	COG1595	DNA-templated transcription, initiation
JR441_RS13475	COG0667	Aldo Keto reductase
JR441_RS13480	COG2851	Citrate transporter
JR441_RS13485	COG0583	DNA-binding transcription factor activity
JR441_RS13490	COG2828	Protein conserved in bacteria
JR441_RS13495	COG3409	Peptidoglycan-binding domain 1 protein
JR441_RS13500	COG5566	PFAM Mor transcription activator
JR441_RS13505	COG0596	Alpha beta hydrolase
JR441_RS13510	COG4991	sh3 domain protein
JR441_RS13515	COG4991	sh3 domain protein
JR441_RS13525	COG0346	lactoylglutathione lyase activity
JR441_RS13535	COG5577	PFAM Coat F domain
JR441_RS13540	COG1063	alcohol dehydrogenase
JR441_RS13550	COG5577	PFAM Coat F domain
JR441_RS13555	COG0789	Transcriptional regulator
JR441_RS13565	COG1064	alcohol dehydrogenase
JR441_RS13570	COG0693	protein deglycase activity
JR441_RS13575	COG1621	beta-fructofuranosidase activity
JR441_RS13580	COG3716	PTS system mannose fructose sorbose family IID component
JR441_RS13585	COG3715	PTS system
JR441_RS13590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS13595	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_RS13600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JR441_RS13600	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JR441_RS13610	COG1113	amino acid transport
JR441_RS13615	COG1280	lysine exporter protein (LysE YggA)
JR441_RS13620	COG1378	Sugar-specific transcriptional regulator TrmB
JR441_RS13625	COG1595	DNA-templated transcription, initiation
JR441_RS13645	COG2124	cytochrome p450
JR441_RS13645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JR441_RS13650	COG1309	transcriptional regulator
JR441_RS13655	COG2226	methyltransferase
JR441_RS13670	COG2116	formate transmembrane transporter activity
JR441_RS13675	COG5609	conserved protein (DUF2294)
JR441_RS13680	COG3383	formate dehydrogenase (NAD+) activity
JR441_RS13685	COG2427	Protein of unknown function (DUF1641)
JR441_RS13695	COG0626	cystathionine gamma-synthase activity
JR441_RS13700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JR441_RS13705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JR441_RS13710	COG2226	methyltransferase
JR441_RS13725	COG0768	penicillin binding
JR441_RS13730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JR441_RS13735	COG0572	uridine kinase
JR441_RS13740	COG0826	peptidase U32
JR441_RS13745	COG0826	peptidase U32
JR441_RS13750	COG4122	O-methyltransferase activity
JR441_RS13755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JR441_RS13760	COG3906	Belongs to the UPF0473 family
JR441_RS13765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JR441_RS13770	COG4472	Bacterial protein of unknown function (DUF965)
JR441_RS13775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JR441_RS13780	COG0628	permease
JR441_RS13785	COG1126	abc transporter atp-binding protein
JR441_RS13790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_RS13795	COG0765	amino acid transport
JR441_RS13800	COG0765	amino acid transport
JR441_RS13815	COG3881	PFAM PRC-barrel domain
JR441_RS13820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JR441_RS13825	COG0457	Tetratricopeptide repeat
JR441_RS13830	COG0482	sulfurtransferase activity
JR441_RS13835	COG1104	cysteine desulfurase activity
JR441_RS13840	COG1959	2 iron, 2 sulfur cluster binding
JR441_RS13845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JR441_RS13850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JR441_RS13860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JR441_RS13865	COG0124	histidyl-tRNA synthetase
JR441_RS13875	COG3103	Sh3 type 3 domain protein
JR441_RS13875	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_RS13875	COG4991	sh3 domain protein
JR441_RS13880	COG1490	D-aminoacyl-tRNA deacylase activity
JR441_RS13885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JR441_RS13890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JR441_RS13895	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JR441_RS13895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JR441_RS13900	COG5416	Lipopolysaccharide assembly protein A domain
JR441_RS13905	COG0490	domain, Protein
JR441_RS13910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JR441_RS13910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JR441_RS13920	COG2244	polysaccharide biosynthetic process
JR441_RS13925	COG2323	membrane
JR441_RS13935	COG1862	Preprotein translocase
JR441_RS13940	COG0343	queuine tRNA-ribosyltransferase activity
JR441_RS13945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JR441_RS13955	COG2255	four-way junction helicase activity
JR441_RS13960	COG0632	four-way junction helicase activity
JR441_RS13970	COG2814	Major facilitator Superfamily
JR441_RS13975	COG0673	inositol 2-dehydrogenase activity
JR441_RS13980	COG2112	serine threonine protein kinase
JR441_RS14000	COG1115	amino acid carrier protein
JR441_RS14005	COG0217	transcriptional regulatory protein
JR441_RS14015	COG1388	LysM domain
JR441_RS14020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JR441_RS14025	COG0157	Belongs to the NadC ModD family
JR441_RS14030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JR441_RS14035	COG1104	cysteine desulfurase activity
JR441_RS14040	COG1827	regulation of RNA biosynthetic process
JR441_RS14045	COG0077	Prephenate dehydratase
JR441_RS14050	COG4492	Belongs to the UPF0735 family
JR441_RS14055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JR441_RS14060	COG3290	protein histidine kinase activity
JR441_RS14070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JR441_RS14075	COG2868	ribosomal protein
JR441_RS14080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JR441_RS14085	COG1994	Peptidase M50
JR441_RS14090	COG0739	heme binding
JR441_RS14095	COG2894	cell division
JR441_RS14100	COG0850	regulation of cytokinetic process
JR441_RS14105	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JR441_RS14115	COG1077	Cell shape determining protein MreB Mrl
JR441_RS14120	COG2003	Belongs to the UPF0758 family
JR441_RS14125	COG0424	maF-like protein
JR441_RS14135	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JR441_RS14140	COG0285	dihydrofolate synthase activity
JR441_RS14145	COG0525	valine-tRNA ligase activity
JR441_RS14155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_RS14160	COG1388	LysM domain
JR441_RS14165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JR441_RS14170	COG0113	porphobilinogen synthase activity
JR441_RS14175	COG1587	Uroporphyrinogen-III synthase
JR441_RS14180	COG0181	hydroxymethylbilane synthase activity
JR441_RS14185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JR441_RS14190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JR441_RS14200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JR441_RS14205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JR441_RS14210	COG1067	ATP-dependent peptidase activity
JR441_RS14210	COG0470	DNA polymerase III
JR441_RS14215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JR441_RS14220	COG0544	peptidyl-prolyl cis-trans isomerase activity
JR441_RS14225	COG0457	Tetratricopeptide repeat
JR441_RS14225	COG1477	protein flavinylation
JR441_RS14230	COG0066	3-isopropylmalate dehydratase activity
JR441_RS14235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JR441_RS14240	COG0473	3-isopropylmalate dehydrogenase activity
JR441_RS14245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JR441_RS14250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JR441_RS14255	COG0440	acetolactate synthase activity
JR441_RS14260	COG0028	Belongs to the TPP enzyme family
JR441_RS14270	COG0454	-acetyltransferase
JR441_RS14275	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
JR441_RS14285	COG0622	Phosphoesterase
JR441_RS14290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JR441_RS14295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JR441_RS14300	COG5401	PFAM Sporulation and spore germination
JR441_RS14305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JR441_RS14310	COG1846	Transcriptional regulator
JR441_RS14315	COG2197	response regulator
JR441_RS14320	COG0824	Thioesterase
JR441_RS14325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JR441_RS14330	COG1053	succinate dehydrogenase
JR441_RS14335	COG2009	succinate dehydrogenase
JR441_RS14340	COG1719	4-vinyl reductase, 4VR
JR441_RS14345	COG0527	aspartate kinase activity
JR441_RS14350	COG0322	excinuclease ABC activity
JR441_RS14355	COG3118	belongs to the thioredoxin family
JR441_RS14360	COG3534	alpha-L-arabinofuranosidase
JR441_RS14365	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JR441_RS14370	COG2086	electron transfer activity
JR441_RS14375	COG1024	Enoyl-CoA hydratase
JR441_RS14380	COG1309	transcriptional regulator
JR441_RS14385	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_RS14390	COG3766	membrane
JR441_RS14395	COG1193	negative regulation of DNA recombination
JR441_RS14400	COG1796	DNA polymerase
JR441_RS14400	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JR441_RS14405	COG1286	toxin biosynthetic process
JR441_RS14410	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JR441_RS14415	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JR441_RS14420	COG0072	phenylalanine-tRNA ligase activity
JR441_RS14420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_RS14425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JR441_RS14435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JR441_RS14445	COG3835	regulator
JR441_RS14450	COG0277	FAD linked oxidase domain protein
JR441_RS14455	COG0247	lactate metabolic process
JR441_RS14460	COG0346	lactoylglutathione lyase activity
JR441_RS14465	COG1966	Carbon starvation protein
JR441_RS14470	COG3534	alpha-L-arabinofuranosidase
JR441_RS14475	COG0395	ABC-type sugar transport system, permease component
JR441_RS14480	COG1175	transmembrane transport
JR441_RS14485	COG1653	transport
JR441_RS14490	COG0371	Dehydrogenase
JR441_RS14495	COG0647	UMP catabolic process
JR441_RS14500	COG0235	Class ii aldolase
JR441_RS14505	COG1069	ribulokinase activity
JR441_RS14510	COG2160	L-arabinose isomerase activity
JR441_RS14515	COG3507	Belongs to the glycosyl hydrolase 43 family
JR441_RS14520	COG1363	Peptidase, m42
JR441_RS14530	COG3326	Membrane
JR441_RS14535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JR441_RS14540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JR441_RS14545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JR441_RS14555	COG1346	cytolysis
JR441_RS14560	COG1380	Effector of murein hydrolase LrgA
JR441_RS14565	COG3279	Response regulator of the LytR AlgR family
JR441_RS14570	COG3275	phosphorelay sensor kinase activity
JR441_RS14575	COG1011	Hydrolase
JR441_RS14580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JR441_RS14590	COG0398	Pfam SNARE associated Golgi protein
JR441_RS14595	COG1484	DNA-dependent DNA replication
JR441_RS14600	COG3611	Membrane attachment protein
JR441_RS14605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JR441_RS14610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
JR441_RS14615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JR441_RS14620	COG1733	regulation of RNA biosynthetic process
JR441_RS14625	COG2814	Major facilitator Superfamily
JR441_RS14630	COG0656	L-ascorbic acid biosynthetic process
JR441_RS14635	COG0237	dephospho-CoA kinase activity
JR441_RS14640	COG1971	Probably functions as a manganese efflux pump
JR441_RS14645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JR441_RS14650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JR441_RS14650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JR441_RS14655	COG5002	protein histidine kinase activity
JR441_RS14660	COG0745	RESPONSE REGULATOR receiver
JR441_RS14665	COG0039	L-malate dehydrogenase activity
JR441_RS14670	COG0538	isocitrate dehydrogenase activity
JR441_RS14675	COG0372	Belongs to the citrate synthase family
JR441_RS14680	COG2707	UPF0756 membrane protein
JR441_RS14685	COG0628	permease
JR441_RS14690	COG3030	protein affecting phage T7 exclusion by the F plasmid
JR441_RS14695	COG0469	pyruvate kinase activity
JR441_RS14700	COG0205	6-phosphofructokinase activity
JR441_RS14705	COG0825	malonyl-CoA metabolic process
JR441_RS14710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JR441_RS14715	COG0281	malic enzyme
JR441_RS14720	COG0587	DNA-directed DNA polymerase activity
JR441_RS14740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JR441_RS14750	COG4109	DRTGG domain
JR441_RS14755	COG0730	response to heat
JR441_RS14760	COG1473	amidohydrolase
JR441_RS14765	COG0196	riboflavin kinase activity
JR441_RS14770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_RS14775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JR441_RS14780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_RS14785	COG1126	abc transporter atp-binding protein
JR441_RS14790	COG0765	amino acid transport
JR441_RS14795	COG0765	amino acid transport
JR441_RS14800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_RS14805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_RS14810	COG0454	-acetyltransferase
JR441_RS14815	COG0583	DNA-binding transcription factor activity
JR441_RS14820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JR441_RS14825	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS14830	COG0165	Argininosuccinate lyase
JR441_RS14835	COG0137	argininosuccinate synthase activity
JR441_RS14840	COG0521	Mo-molybdopterin cofactor biosynthetic process
JR441_RS14845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JR441_RS14855	COG0827	DNA restriction-modification system
JR441_RS14860	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JR441_RS14865	COG3874	Sporulation protein YtfJ
JR441_RS14875	COG1714	RDD family
JR441_RS14880	COG0616	signal peptide processing
JR441_RS14885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JR441_RS14890	COG1574	metal-dependent hydrolase with the TIM-barrel fold
JR441_RS14895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JR441_RS14905	COG0301	tRNA thio-modification
JR441_RS14910	COG1104	cysteine desulfurase activity
JR441_RS14915	COG1114	Component of the transport system for branched-chain amino acids
JR441_RS14920	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JR441_RS14925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JR441_RS14930	COG1309	transcriptional regulator
JR441_RS14935	COG1956	GAF domain-containing protein
JR441_RS14940	COG2203	Gaf domain
JR441_RS14940	COG2199	diguanylate cyclase activity
JR441_RS14945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JR441_RS14950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JR441_RS14955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JR441_RS14960	COG0454	-acetyltransferase
JR441_RS14965	COG0517	IMP dehydrogenase activity
JR441_RS14970	COG0123	including yeast histone deacetylase and acetoin utilization protein
JR441_RS14975	COG1360	Flagellar Motor Protein
JR441_RS14980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JR441_RS14985	COG1609	Transcriptional regulator
JR441_RS14990	COG1605	Chorismate mutase
JR441_RS14990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JR441_RS14995	COG3118	belongs to the thioredoxin family
JR441_RS15000	COG4980	gas vesicle protein
JR441_RS15005	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JR441_RS15010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JR441_RS15015	COG1674	ftsk spoiiie
JR441_RS15020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_RS15025	COG4848	Belongs to the UPF0354 family
JR441_RS15030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_RS15045	COG1363	Peptidase, m42
JR441_RS15050	COG5584	Small secreted protein
JR441_RS15055	COG0281	malic enzyme
JR441_RS15060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_RS15065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JR441_RS15075	COG0510	thiamine kinase activity
JR441_RS15080	COG1523	belongs to the glycosyl hydrolase 13 family
JR441_RS15085	COG1597	lipid kinase activity
JR441_RS15095	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JR441_RS15100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JR441_RS15105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR441_RS15110	COG2252	PERMEase
JR441_RS15115	COG4473	ABC transporter
JR441_RS15120	COG1131	(ABC) transporter
JR441_RS15125	COG1349	DNA-binding transcription factor activity
JR441_RS15130	COG1187	pseudouridine synthase activity
JR441_RS15135	COG2244	polysaccharide biosynthetic process
JR441_RS15140	COG2081	HI0933 family
JR441_RS15145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JR441_RS15155	COG5578	integral membrane protein
JR441_RS15160	COG0673	inositol 2-dehydrogenase activity
JR441_RS15165	COG1653	transport
JR441_RS15170	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JR441_RS15175	COG4209	transmembrane transport
JR441_RS15180	COG2207	Transcriptional regulator
JR441_RS15185	COG1653	transport
JR441_RS15190	COG0395	ABC-type sugar transport system, permease component
JR441_RS15195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_RS15200	COG2124	cytochrome p450
JR441_RS15205	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JR441_RS15215	COG0156	8-amino-7-oxononanoate synthase activity
JR441_RS15220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JR441_RS15230	COG1073	alpha beta
JR441_RS15235	COG1609	Transcriptional regulator
JR441_RS15240	COG1653	transport
JR441_RS15245	COG1175	transmembrane transport
JR441_RS15250	COG0395	ABC-type sugar transport system, permease component
JR441_RS15255	COG1486	melibiose metabolic process
JR441_RS15260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JR441_RS15265	COG0495	leucyl-tRNA aminoacylation
JR441_RS15275	COG2202	Pas domain
JR441_RS15275	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_RS15280	COG2814	Major facilitator Superfamily
JR441_RS15285	COG2433	Pfam Transposase IS66
JR441_RS15290	COG0577	efflux transmembrane transporter activity
JR441_RS15295	COG1136	(ABC) transporter
JR441_RS15300	COG2205	protein histidine kinase activity
JR441_RS15305	COG0745	RESPONSE REGULATOR receiver
JR441_RS15310	COG0577	efflux transmembrane transporter activity
JR441_RS15315	COG1136	(ABC) transporter
JR441_RS15330	COG1131	(ABC) transporter
JR441_RS15335	COG1725	Transcriptional regulator
JR441_RS15350	COG1242	4 iron, 4 sulfur cluster binding
JR441_RS15355	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JR441_RS15365	COG2267	carboxylic ester hydrolase activity
JR441_RS15370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JR441_RS15375	COG1113	amino acid transport
JR441_RS15380	COG0367	asparagine synthase
JR441_RS15385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JR441_RS15390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JR441_RS15400	COG1506	peptidase
JR441_RS15405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JR441_RS15410	COG1116	anion transmembrane transporter activity
JR441_RS15415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JR441_RS15420	COG0494	nUDIX hydrolase
JR441_RS15425	COG4824	toxin secretion phage lysis holin
JR441_RS15430	COG0783	Belongs to the Dps family
JR441_RS15445	COG1854	S-ribosylhomocysteine lyase activity
JR441_RS15450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JR441_RS15455	COG0288	reversible hydration of carbon dioxide
JR441_RS15460	COG0254	rRNA binding
JR441_RS15465	COG1271	oxidase subunit
JR441_RS15470	COG1294	oxidase, subunit
JR441_RS15480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JR441_RS15485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JR441_RS15485	COG1321	iron dependent repressor
JR441_RS15490	COG1121	(ABC) transporter
JR441_RS15495	COG0803	Belongs to the bacterial solute-binding protein 9 family
JR441_RS15500	COG4948	Mandelate Racemase Muconate Lactonizing
JR441_RS15505	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_RS15510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JR441_RS15515	COG0596	Alpha beta hydrolase
JR441_RS15520	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JR441_RS15525	COG1169	isochorismate synthase
JR441_RS15530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JR441_RS15535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JR441_RS15540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JR441_RS15545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_RS15550	COG0438	transferase activity, transferring glycosyl groups
JR441_RS15560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_RS15565	COG0438	transferase activity, transferring glycosyl groups
JR441_RS15570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_RS15575	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
JR441_RS15580	COG0058	SHG alpha-glucan phosphorylase activity
JR441_RS15585	COG0297	glycogen (starch) synthase activity
JR441_RS15590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JR441_RS15595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JR441_RS15600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JR441_RS15725	COG3859	Proton-coupled thiamine transporter YuaJ
JR441_RS15730	COG1247	-acetyltransferase
JR441_RS15735	COG2268	Band 7 protein
JR441_RS15740	COG1585	Membrane protein implicated in regulation of membrane protease activity
JR441_RS15745	COG2318	DinB family
JR441_RS15755	COG1454	alcohol dehydrogenase
JR441_RS15760	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS15765	COG1510	regulation of RNA biosynthetic process
JR441_RS15775	COG0569	domain protein
JR441_RS15780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JR441_RS15785	COG4682	membrane
JR441_RS15790	COG1705	Flagellar rod assembly protein muramidase FlgJ
JR441_RS15795	COG0477	Major facilitator Superfamily
JR441_RS15800	COG5553	Cysteine dioxygenase type I
JR441_RS15810	COG1968	undecaprenyl-diphosphatase activity
JR441_RS15815	COG0628	permease
JR441_RS15820	COG0673	inositol 2-dehydrogenase activity
JR441_RS15825	COG4806	L-rhamnose isomerase
JR441_RS15830	COG3254	rhamnose metabolic process
JR441_RS15835	COG1070	Carbohydrate kinase
JR441_RS15840	COG1349	DNA-binding transcription factor activity
JR441_RS15845	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS15845	COG3347	Dehydrogenase
JR441_RS15850	COG0840	transmembrane signaling receptor activity
JR441_RS15855	COG0840	transmembrane signaling receptor activity
JR441_RS15860	COG0840	transmembrane signaling receptor activity
JR441_RS15865	COG0840	transmembrane signaling receptor activity
JR441_RS15880	COG0432	Pfam Uncharacterised protein family UPF0047
JR441_RS15890	COG0366	Alpha amylase catalytic
JR441_RS15895	COG1253	flavin adenine dinucleotide binding
JR441_RS15900	COG2738	Putative neutral zinc metallopeptidase
JR441_RS15915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JR441_RS15930	COG0166	Belongs to the GPI family
JR441_RS15935	COG1979	alcohol dehydrogenase
JR441_RS15940	COG1979	alcohol dehydrogenase
JR441_RS15945	COG2155	Conserved Protein
JR441_RS15950	COG1098	S1 RNA binding domain
JR441_RS15955	COG0436	Aminotransferase
JR441_RS15960	COG1522	sequence-specific DNA binding
JR441_RS15965	COG2267	carboxylic ester hydrolase activity
JR441_RS15975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JR441_RS15980	COG2205	protein histidine kinase activity
JR441_RS15990	COG5018	Exonuclease
JR441_RS15995	COG2814	Major facilitator Superfamily
JR441_RS16000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JR441_RS16005	COG3011	Protein conserved in bacteria
JR441_RS16015	COG3290	protein histidine kinase activity
JR441_RS16020	COG4565	transcriptional regulatory protein
JR441_RS16025	COG1744	ABC transporter substrate-binding protein PnrA-like
JR441_RS16030	COG3845	ABC transporter
JR441_RS16035	COG4603	Belongs to the binding-protein-dependent transport system permease family
JR441_RS16040	COG1079	Belongs to the binding-protein-dependent transport system permease family
JR441_RS16045	COG3493	citrate carrier protein
JR441_RS16055	COG2111	Na H antiporter
JR441_RS16055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JR441_RS16060	COG2111	Na H antiporter
JR441_RS16065	COG1006	Multisubunit Na H antiporter MnhC subunit
JR441_RS16070	COG0651	ATP synthesis coupled electron transport
JR441_RS16075	COG1863	multisubunit Na H antiporter MnhE subunit
JR441_RS16080	COG2212	antiporter activity
JR441_RS16085	COG1320	monovalent cation:proton antiporter activity
JR441_RS16090	COG2050	protein possibly involved in aromatic compounds catabolism
JR441_RS16095	COG2197	response regulator
JR441_RS16110	COG0142	geranyltranstransferase activity
JR441_RS16130	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JR441_RS16135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JR441_RS16140	COG1335	isochorismatase
JR441_RS16145	COG5506	Protein of unknown function (DUF1694)
JR441_RS16160	COG0628	permease
JR441_RS16175	COG1418	mRNA catabolic process
JR441_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS16190	COG1511	domain protein
JR441_RS16195	COG1674	ftsk spoiiie
JR441_RS16195	COG0433	COG0433 Predicted ATPase
JR441_RS16200	COG4499	WXG100 protein secretion system (Wss), protein YukC
JR441_RS16205	COG5417	Belongs to the EsaB family
JR441_RS16210	COG4842	Belongs to the WXG100 family
JR441_RS16215	COG2508	Transcriptional regulator
JR441_RS16215	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JR441_RS16220	COG0686	Belongs to the AlaDH PNT family
JR441_RS16225	COG5634	Uncharacterized conserved protein (DUF2278)
JR441_RS16230	COG3251	PFAM MbtH domain protein
JR441_RS16235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS16240	COG1535	isochorismatase
JR441_RS16240	COG3433	isochorismatase activity
JR441_RS16245	COG1021	2,3-dihydroxybenzoate-AMP ligase
JR441_RS16250	COG1169	isochorismate synthase
JR441_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS16260	COG2819	hydrolase of the alpha beta superfamily
JR441_RS16265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JR441_RS16270	COG1268	BioY protein
JR441_RS16275	COG2056	Na+-H+ antiporter family
JR441_RS16280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JR441_RS16285	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
JR441_RS16290	COG3584	3D domain protein
JR441_RS16305	COG1252	NADH dehydrogenase
JR441_RS16310	COG0492	ferredoxin-NADP+ reductase activity
JR441_RS16320	COG0516	GMP reductase activity
JR441_RS16325	COG2808	Putative FMN-binding domain
JR441_RS16330	COG0456	acetyltransferase
JR441_RS16335	COG0316	Belongs to the HesB IscA family
JR441_RS16340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JR441_RS16345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JR441_RS16350	COG4844	belongs to the
JR441_RS16355	COG1252	NADH dehydrogenase
JR441_RS16360	COG4837	Protein of unknown function (DUF1462)
JR441_RS16365	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JR441_RS16370	COG1506	peptidase
JR441_RS16370	COG4946	Tricorn protease homolog
JR441_RS16370	COG0823	Involved in the tonB-independent uptake of proteins
JR441_RS16375	COG0083	homoserine kinase activity
JR441_RS16380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JR441_RS16385	COG0460	homoserine dehydrogenase
JR441_RS16390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_RS16395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JR441_RS16400	COG0647	UMP catabolic process
JR441_RS16405	COG2445	Protein of unknown function DUF86
JR441_RS16410	COG4470	Protein conserved in bacteria
JR441_RS16420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JR441_RS16425	COG0739	heme binding
JR441_RS16435	COG3377	Domain of unknown function (DUF1805)
JR441_RS16440	COG0737	Belongs to the 5'-nucleotidase family
JR441_RS16445	COG0730	response to heat
JR441_RS16450	COG1801	Protein of unknown function DUF72
JR441_RS16460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JR441_RS16465	COG2508	Transcriptional regulator
JR441_RS16470	COG2233	PERMEase
JR441_RS16475	COG2233	PERMEase
JR441_RS16480	COG3648	Uricase
JR441_RS16480	COG3195	allantoin biosynthetic process
JR441_RS16485	COG2351	hydroxyisourate hydrolase activity
JR441_RS16495	COG2080	2 iron, 2 sulfur cluster binding
JR441_RS16500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JR441_RS16505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JR441_RS16510	COG2068	MobA-Related Protein
JR441_RS16515	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JR441_RS16520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JR441_RS16525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR441_RS16535	COG2356	endonuclease I
JR441_RS16540	COG3842	ATPase activity
JR441_RS16545	COG2188	Transcriptional regulator
JR441_RS16550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_RS16555	COG0395	ABC-type sugar transport system, permease component
JR441_RS16560	COG1175	transmembrane transport
JR441_RS16565	COG1653	transport
JR441_RS16570	COG2222	sugar isomerase
JR441_RS16575	COG0322	excinuclease ABC activity
JR441_RS16580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JR441_RS16595	COG0346	lactoylglutathione lyase activity
JR441_RS16600	COG0640	Transcriptional regulator
JR441_RS16605	COG0719	Fe-S assembly protein
JR441_RS16610	COG0822	iron-sulfur transferase activity
JR441_RS16615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JR441_RS16620	COG0719	Fe-S assembly protein
JR441_RS16625	COG0396	ATPase activity
JR441_RS16635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JR441_RS16640	COG1464	Belongs to the NlpA lipoprotein family
JR441_RS16645	COG2011	ABC-type metal ion transport system permease component
JR441_RS16650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JR441_RS16660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_RS16665	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JR441_RS16675	COG0509	glycine decarboxylation via glycine cleavage system
JR441_RS16680	COG1393	Belongs to the ArsC family
JR441_RS16685	COG1960	acyl-CoA dehydrogenase activity
JR441_RS16690	COG0183	Belongs to the thiolase family
JR441_RS16695	COG1250	3-hydroxyacyl-CoA dehydrogenase
JR441_RS16695	COG1024	Enoyl-CoA hydratase
JR441_RS16705	COG0506	proline dehydrogenase activity
JR441_RS16715	COG5577	PFAM Coat F domain
JR441_RS16720	COG1846	Transcriptional regulator
JR441_RS16725	COG0477	Major facilitator Superfamily
JR441_RS16730	COG1942	4-Oxalocrotonate Tautomerase
JR441_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS16740	COG0583	DNA-binding transcription factor activity
JR441_RS16750	COG1120	ATPase activity
JR441_RS16765	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS16770	COG0783	Belongs to the Dps family
JR441_RS16775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR441_RS16780	COG0745	RESPONSE REGULATOR receiver
JR441_RS16785	COG2770	Histidine kinase
JR441_RS16785	COG2205	protein histidine kinase activity
JR441_RS16795	COG1309	transcriptional regulator
JR441_RS16800	COG0114	fumarate hydratase activity
JR441_RS16810	COG0697	spore germination
JR441_RS16815	COG0814	amino acid
JR441_RS16825	COG2197	response regulator
JR441_RS16830	COG4585	Histidine kinase
JR441_RS16835	COG4758	membrane
JR441_RS16840	COG3595	metallopeptidase activity
JR441_RS16845	COG1842	Phage shock protein A
JR441_RS16850	COG4758	membrane
JR441_RS16855	COG2814	Major facilitator Superfamily
JR441_RS16860	COG2096	Adenosyltransferase
JR441_RS16865	COG1120	ATPase activity
JR441_RS16870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS16875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_RS16880	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS16885	COG3386	PFAM SMP-30 Gluconolaconase
JR441_RS16890	COG2205	protein histidine kinase activity
JR441_RS16895	COG0745	RESPONSE REGULATOR receiver
JR441_RS16905	COG1191	sigma factor activity
JR441_RS16915	COG2140	Oxalate decarboxylase
JR441_RS16925	COG0577	efflux transmembrane transporter activity
JR441_RS16930	COG1136	(ABC) transporter
JR441_RS16935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JR441_RS16940	COG1120	ATPase activity
JR441_RS16945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS16950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_RS16955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_RS16960	COG0531	amino acid
JR441_RS16970	COG1988	membrane-bound metal-dependent
JR441_RS16975	COG1368	sulfuric ester hydrolase activity
JR441_RS16980	COG1910	domain protein
JR441_RS16985	COG0725	ABC transporter, periplasmic molybdate-binding protein
JR441_RS16990	COG4149	molybdate abc transporter
JR441_RS16995	COG0656	L-ascorbic acid biosynthetic process
JR441_RS17005	COG0025	NhaP-type Na H and K H
JR441_RS17010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JR441_RS17015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JR441_RS17020	COG3973	AAA domain
JR441_RS17030	COG2860	membrane
JR441_RS17035	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JR441_RS17040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JR441_RS17045	COG2217	Heavy metal translocating P-type atpase
JR441_RS17050	COG2217	Heavy metal translocating P-type atpase
JR441_RS17055	COG2608	mercury ion transmembrane transporter activity
JR441_RS17060	COG1937	Protein conserved in bacteria
JR441_RS17065	COG0673	inositol 2-dehydrogenase activity
JR441_RS17070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JR441_RS17075	COG1289	transmembrane transporter activity
JR441_RS17085	COG2076	Multidrug Resistance protein
JR441_RS17090	COG1309	transcriptional regulator
JR441_RS17095	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS17105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JR441_RS17110	COG0557	exoribonuclease II activity
JR441_RS17115	COG1647	Serine aminopeptidase, S33
JR441_RS17120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JR441_RS17125	COG0596	Alpha beta hydrolase
JR441_RS17130	COG1476	TRANSCRIPTIONal
JR441_RS17135	COG1396	sequence-specific DNA binding
JR441_RS17140	COG1396	sequence-specific DNA binding
JR441_RS17145	COG1733	regulation of RNA biosynthetic process
JR441_RS17150	COG0840	transmembrane signaling receptor activity
JR441_RS17155	COG1174	glycine betaine transport
JR441_RS17160	COG1732	Glycine betaine
JR441_RS17165	COG1174	glycine betaine transport
JR441_RS17170	COG1125	glycine betaine transport
JR441_RS17170	COG0517	IMP dehydrogenase activity
JR441_RS17175	COG1510	regulation of RNA biosynthetic process
JR441_RS17180	COG1174	glycine betaine transport
JR441_RS17185	COG1732	Glycine betaine
JR441_RS17190	COG1174	glycine betaine transport
JR441_RS17195	COG1125	glycine betaine transport
JR441_RS17195	COG0517	IMP dehydrogenase activity
JR441_RS17200	COG1510	regulation of RNA biosynthetic process
JR441_RS17205	COG2095	MarC family integral membrane protein
JR441_RS17215	COG3064	Membrane
JR441_RS17220	COG4640	response to antibiotic
JR441_RS17225	COG0456	acetyltransferase
JR441_RS17240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR441_RS17255	COG0436	Aminotransferase
JR441_RS17260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_RS17265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JR441_RS17275	COG2234	aminopeptidase activity
JR441_RS17280	COG0148	phosphopyruvate hydratase activity
JR441_RS17285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JR441_RS17290	COG0149	triose-phosphate isomerase activity
JR441_RS17295	COG0126	phosphoglycerate kinase activity
JR441_RS17300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JR441_RS17305	COG2390	Transcriptional regulator
JR441_RS17310	COG2814	Major facilitator Superfamily
JR441_RS17315	COG1609	Transcriptional regulator
JR441_RS17320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_RS17325	COG0583	DNA-binding transcription factor activity
JR441_RS17330	COG0697	spore germination
JR441_RS17335	COG1113	amino acid transport
JR441_RS17340	COG3858	chitin binding
JR441_RS17345	COG1556	Lactate utilization protein
JR441_RS17350	COG1139	Iron-sulfur cluster binding protein
JR441_RS17355	COG0247	lactate metabolic process
JR441_RS17360	COG2197	response regulator
JR441_RS17365	COG4585	Histidine kinase
JR441_RS17370	COG0842	Transport permease protein
JR441_RS17375	COG1131	(ABC) transporter
JR441_RS17380	COG0596	Alpha beta hydrolase
JR441_RS17385	COG2208	phosphoserine phosphatase activity
JR441_RS17390	COG3867	Arabinogalactan endo-beta-1,4-galactanase
JR441_RS17395	COG1874	Beta-galactosidase
JR441_RS17400	COG3833	ABC-type maltose transport systems, permease component
JR441_RS17410	COG2182	Extracellular solute-binding protein
JR441_RS17415	COG1609	Transcriptional regulator
JR441_RS17420	COG2186	Transcriptional regulator
JR441_RS17425	COG1620	l-lactate permease
JR441_RS17430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JR441_RS17440	COG5039	Polysaccharide pyruvyl transferase
JR441_RS17445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JR441_RS17450	COG0110	maltose O-acetyltransferase activity
JR441_RS17455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JR441_RS17460	COG2244	polysaccharide biosynthetic process
JR441_RS17465	COG1216	Glycosyl transferase, family 2
JR441_RS17470	COG5039	Polysaccharide pyruvyl transferase
JR441_RS17475	COG1216	Glycosyl transferase, family 2
JR441_RS17485	COG0438	transferase activity, transferring glycosyl groups
JR441_RS17490	COG1215	transferase activity, transferring glycosyl groups
JR441_RS17495	COG0438	transferase activity, transferring glycosyl groups
JR441_RS17500	COG1086	Polysaccharide biosynthesis protein
JR441_RS17505	COG0489	protein tyrosine kinase activity
JR441_RS17510	COG3944	biosynthesis protein
JR441_RS17515	COG1396	sequence-specific DNA binding
JR441_RS17520	COG2272	Belongs to the type-B carboxylesterase lipase family
JR441_RS17530	COG3479	Phenolic acid decarboxylase
JR441_RS17540	COG1794	racemase activity, acting on amino acids and derivatives
JR441_RS17550	COG1621	beta-fructofuranosidase activity
JR441_RS17555	COG1621	beta-fructofuranosidase activity
JR441_RS17560	COG0531	amino acid
JR441_RS17565	COG1309	transcriptional regulator
JR441_RS17570	COG2076	Multidrug Resistance protein
JR441_RS17575	COG2076	Multidrug Resistance protein
JR441_RS17585	COG0277	FAD linked oxidase domain protein
JR441_RS17590	COG3621	Patatin-like phospholipase
JR441_RS17630	COG0740	serine-type endopeptidase activity
JR441_RS17635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JR441_RS17640	COG0366	Alpha amylase catalytic
JR441_RS17645	COG1554	hydrolase, family 65, central catalytic
JR441_RS17650	COG5521	maltodextrose utilization protein MalA
JR441_RS17655	COG3833	ABC-type maltose transport systems, permease component
JR441_RS17660	COG1175	transmembrane transport
JR441_RS17665	COG2182	Extracellular solute-binding protein
JR441_RS17670	COG0366	Alpha amylase catalytic
JR441_RS17675	COG1609	Transcriptional regulator
JR441_RS17680	COG1611	Belongs to the LOG family
JR441_RS17685	COG1694	Mazg nucleotide pyrophosphohydrolase
JR441_RS17690	COG0659	secondary active sulfate transmembrane transporter activity
JR441_RS17695	COG0288	reversible hydration of carbon dioxide
JR441_RS17700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JR441_RS17705	COG0577	efflux transmembrane transporter activity
JR441_RS17710	COG1136	(ABC) transporter
JR441_RS17715	COG5002	protein histidine kinase activity
JR441_RS17720	COG0745	RESPONSE REGULATOR receiver
JR441_RS17730	COG2162	N-hydroxyarylamine O-acetyltransferase activity
JR441_RS17735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_RS17740	COG1481	regulation of sporulation
JR441_RS17745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JR441_RS17750	COG1660	Displays ATPase and GTPase activities
JR441_RS17755	COG1051	belongs to the nudix hydrolase family
JR441_RS17760	COG0492	ferredoxin-NADP+ reductase activity
JR441_RS17765	COG3883	PFAM NLP P60 protein
JR441_RS17765	COG0791	NLP P60 protein
JR441_RS17770	COG0457	Tetratricopeptide repeat
JR441_RS17775	COG1132	(ABC) transporter
JR441_RS17795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JR441_RS17795	COG0140	phosphoribosyl-ATP diphosphatase activity
JR441_RS17800	COG0107	imidazoleglycerol-phosphate synthase activity
JR441_RS17805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JR441_RS17810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JR441_RS17815	COG0131	Imidazoleglycerol-phosphate dehydratase
JR441_RS17820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JR441_RS17825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JR441_RS17830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JR441_RS17835	COG4990	cell redox homeostasis
JR441_RS17840	COG5297	Belongs to the glycosyl hydrolase family 6
JR441_RS17845	COG0110	maltose O-acetyltransferase activity
JR441_RS17850	COG0546	phosphoglycolate phosphatase activity
JR441_RS17855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JR441_RS17860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JR441_RS17865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JR441_RS17870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JR441_RS17875	COG0363	glucosamine-6-phosphate deaminase activity
JR441_RS17880	COG2188	Transcriptional regulator
JR441_RS17885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JR441_RS17890	COG1950	PFAM Membrane protein of
JR441_RS17895	COG1983	PspC domain protein
JR441_RS17900	COG3595	metallopeptidase activity
JR441_RS17915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JR441_RS17920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JR441_RS17925	COG0556	nucleotide-excision repair
JR441_RS17930	COG4897	Protein conserved in bacteria
JR441_RS17935	COG0574	Belongs to the PEP-utilizing enzyme family
JR441_RS17935	COG3848	Pyruvate phosphate dikinase
JR441_RS17940	COG1309	transcriptional regulator
JR441_RS17945	COG2814	Major facilitator Superfamily
JR441_RS17950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR441_RS17960	COG0793	Belongs to the peptidase S41A family
JR441_RS17960	COG3409	Peptidoglycan-binding domain 1 protein
JR441_RS17965	COG2177	Part of the ABC transporter FtsEX involved in
JR441_RS17970	COG2884	Cell division ATP-binding protein ftsE
JR441_RS17975	COG2010	Cytochrome c
JR441_RS17980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_RS17990	COG0653	protein targeting
JR441_RS17995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JR441_RS18010	COG1516	flagellar protein fliS
JR441_RS18015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JR441_RS18020	COG1334	flagellar protein FlaG
JR441_RS18025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JR441_RS18030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JR441_RS18035	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
JR441_RS18045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JR441_RS18050	COG1256	bacterial-type flagellum assembly
JR441_RS18050	COG4786	Flagellar basal body rod
JR441_RS18055	COG3418	PFAM FlgN family protein
JR441_RS18060	COG2747	anti-sigma28 factor FlgM
JR441_RS18070	COG1040	competence protein
JR441_RS18080	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JR441_RS18085	COG1307	EDD domain protein, DegV family
JR441_RS18090	COG2197	response regulator
JR441_RS18095	COG4585	Histidine kinase
JR441_RS18100	COG1739	Uncharacterized protein family UPF0029
JR441_RS18105	COG1316	TRANSCRIPTIONal
JR441_RS18110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JR441_RS18115	COG0438	transferase activity, transferring glycosyl groups
JR441_RS18120	COG1215	transferase activity, transferring glycosyl groups
JR441_RS18125	COG3206	protein involved in exopolysaccharide biosynthesis
JR441_RS18130	COG3307	-O-antigen
JR441_RS18135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JR441_RS18140	COG0297	glycogen (starch) synthase activity
JR441_RS18140	COG0438	transferase activity, transferring glycosyl groups
JR441_RS18145	COG2244	polysaccharide biosynthetic process
JR441_RS18160	COG2247	cell wall binding repeat
JR441_RS18160	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_RS18165	COG2385	sporulation resulting in formation of a cellular spore
JR441_RS18165	COG2247	cell wall binding repeat
JR441_RS18175	COG1316	TRANSCRIPTIONal
JR441_RS18180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JR441_RS18200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JR441_RS18205	COG1134	teichoic acid transport
JR441_RS18210	COG1682	transport, permease protein
JR441_RS18215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JR441_RS18215	COG1215	transferase activity, transferring glycosyl groups
JR441_RS18220	COG0463	Glycosyl transferase, family 2
JR441_RS18265	COG4193	domain, Protein
JR441_RS18270	COG1482	cell wall glycoprotein biosynthetic process
JR441_RS18275	COG0697	spore germination
JR441_RS18280	COG0814	amino acid
JR441_RS18290	COG2814	Major facilitator Superfamily
JR441_RS18295	COG1316	TRANSCRIPTIONal
JR441_RS18300	COG0561	phosphatase activity
JR441_RS18305	COG0791	NLP P60 protein
JR441_RS18315	COG2843	Capsule synthesis protein
JR441_RS18325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JR441_RS18330	COG1609	Transcriptional regulator
JR441_RS18335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_RS18340	COG1869	D-ribose catabolic process
JR441_RS18345	COG1129	ABC transporter
JR441_RS18350	COG1172	Belongs to the binding-protein-dependent transport system permease family
JR441_RS18355	COG1879	ABC-type sugar transport system periplasmic component
JR441_RS18360	COG3103	Sh3 type 3 domain protein
JR441_RS18370	COG2249	NAD(P)H dehydrogenase (quinone) activity
JR441_RS18375	COG3527	Alpha-acetolactate decarboxylase
JR441_RS18380	COG0028	Belongs to the TPP enzyme family
JR441_RS18385	COG0583	DNA-binding transcription factor activity
JR441_RS18390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JR441_RS18405	COG5337	Spore coat protein CotH
JR441_RS18415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JR441_RS18425	COG0405	Gamma-glutamyltransferase
JR441_RS18430	COG1522	sequence-specific DNA binding
JR441_RS18435	COG2059	Chromate
JR441_RS18440	COG2059	Chromate
JR441_RS18450	COG0655	NAD(P)H dehydrogenase (quinone) activity
JR441_RS18455	COG0583	DNA-binding transcription factor activity
JR441_RS18460	COG1515	deoxyribonuclease V activity
JR441_RS18475	COG5444	nuclease activity
JR441_RS18490	COG3878	Protein conserved in bacteria
JR441_RS18495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JR441_RS18500	COG4464	protein tyrosine phosphatase activity
JR441_RS18505	COG0489	protein tyrosine kinase activity
JR441_RS18510	COG3944	biosynthesis protein
JR441_RS18520	COG4715	Zinc finger, swim domain protein
JR441_RS18525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JR441_RS18530	COG0561	phosphatase activity
JR441_RS18535	COG1349	DNA-binding transcription factor activity
JR441_RS18540	COG0629	single-stranded DNA binding
JR441_RS18555	COG3764	Sortase (surface protein transpeptidase)
JR441_RS18560	COG0745	RESPONSE REGULATOR receiver
JR441_RS18560	COG2972	Histidine kinase
JR441_RS18565	COG1970	mechanosensitive ion channel activity
JR441_RS18570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JR441_RS18575	COG0457	Tetratricopeptide repeat
JR441_RS18580	COG4786	Flagellar basal body rod
JR441_RS18585	COG4786	Flagellar basal body rod
JR441_RS18590	COG1077	Cell shape determining protein MreB Mrl
JR441_RS18595	COG1609	Transcriptional regulator
JR441_RS18605	COG1846	Transcriptional regulator
JR441_RS18610	COG2814	Major facilitator Superfamily
JR441_RS18615	COG3420	alginic acid biosynthetic process
JR441_RS18620	COG1953	Uracil, thiamine, allantoin
JR441_RS18625	COG0477	Major facilitator Superfamily
JR441_RS18630	COG1335	isochorismatase
JR441_RS18640	COG0004	ammonium transporteR
JR441_RS18645	COG0347	Belongs to the P(II) protein family
JR441_RS18650	COG0671	phosphoesterase, PA-phosphatase related
JR441_RS18660	COG0739	heme binding
JR441_RS18665	COG1247	-acetyltransferase
JR441_RS18685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JR441_RS18690	COG0789	Transcriptional regulator
JR441_RS18700	COG2910	NAD(P)H-binding
JR441_RS18705	COG1959	2 iron, 2 sulfur cluster binding
JR441_RS18710	COG0804	urea catabolic process
JR441_RS18715	COG0832	Belongs to the urease beta subunit family
JR441_RS18720	COG0831	urea catabolic process
JR441_RS18735	COG3237	CsbD-like
JR441_RS18740	COG1994	Peptidase M50
JR441_RS18745	COG0457	Tetratricopeptide repeat
JR441_RS18750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JR441_RS18755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JR441_RS18765	COG2304	oxidoreductase activity
JR441_RS18775	COG2304	oxidoreductase activity
JR441_RS18780	COG2385	sporulation resulting in formation of a cellular spore
JR441_RS18785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JR441_RS18795	COG4836	Membrane
JR441_RS18805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JR441_RS18810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JR441_RS18815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JR441_RS18820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JR441_RS18825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JR441_RS18830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JR441_RS18840	COG0356	it plays a direct role in the translocation of protons across the membrane
JR441_RS18850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JR441_RS18855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JR441_RS18860	COG4475	Protein of unknown function (DUF436)
JR441_RS18865	COG0698	ribose 5-phosphate isomerase
JR441_RS18870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JR441_RS18875	COG1971	Probably functions as a manganese efflux pump
JR441_RS18880	COG0009	L-threonylcarbamoyladenylate synthase
JR441_RS18885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JR441_RS18905	COG2890	protein-(glutamine-N5) methyltransferase activity
JR441_RS18910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JR441_RS18915	COG0346	lactoylglutathione lyase activity
JR441_RS18920	COG0789	Transcriptional regulator
JR441_RS18925	COG0679	Auxin Efflux Carrier
JR441_RS18930	COG0281	malic enzyme
JR441_RS18935	COG1435	thymidine kinase activity
JR441_RS18945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JR441_RS18955	COG1494	fructose-1,6-bisphosphatase
JR441_RS18960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JR441_RS18965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JR441_RS18970	COG0191	fructose-bisphosphate aldolase activity
JR441_RS18975	COG2204	response regulator
JR441_RS18980	COG4821	SIS domain
JR441_RS18985	COG0504	CTP synthase activity
JR441_RS18990	COG3343	RNA polymerase activity
JR441_RS18995	COG1960	acyl-CoA dehydrogenase activity
JR441_RS19000	COG0247	lactate metabolic process
JR441_RS19000	COG2181	nitrate reductase activity
JR441_RS19005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JR441_RS19010	COG4294	response to UV
JR441_RS19025	COG1132	(ABC) transporter
JR441_RS19030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JR441_RS19035	COG2181	nitrate reductase activity
JR441_RS19040	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
JR441_RS19045	COG1140	nitrate reductase beta subunit
JR441_RS19050	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JR441_RS19055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JR441_RS19065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JR441_RS19070	COG2223	nitrite transmembrane transporter activity
JR441_RS19075	COG0018	arginyl-trna synthetase
JR441_RS19080	COG4506	Protein conserved in bacteria
JR441_RS19095	COG0535	radical SAM domain protein
JR441_RS19105	COG1131	(ABC) transporter
JR441_RS19110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JR441_RS19115	COG0612	Peptidase, M16
JR441_RS19120	COG0612	Peptidase, M16
JR441_RS19130	COG3391	amine dehydrogenase activity
JR441_RS19135	COG3391	amine dehydrogenase activity
JR441_RS19140	COG0457	Tetratricopeptide repeat
JR441_RS19155	COG0010	Belongs to the arginase family
JR441_RS19160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JR441_RS19165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JR441_RS19175	COG1994	Peptidase M50
JR441_RS19180	COG1942	4-Oxalocrotonate Tautomerase
JR441_RS19185	COG1846	Transcriptional regulator
JR441_RS19190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JR441_RS19195	COG0477	Major facilitator Superfamily
JR441_RS19200	COG1959	2 iron, 2 sulfur cluster binding
JR441_RS19205	COG3465	dGTPase activity
JR441_RS19210	COG1078	dGTPase activity
JR441_RS19215	COG4844	belongs to the
JR441_RS19225	COG0697	spore germination
JR441_RS19230	COG0095	Lipoate-protein ligase
JR441_RS19235	COG0583	DNA-binding transcription factor activity
JR441_RS19240	COG0280	phosphate acetyltransferase
JR441_RS19245	COG3253	May function as heme-dependent peroxidase
JR441_RS19250	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS19255	COG0436	Aminotransferase
JR441_RS19260	COG2814	Major facilitator Superfamily
JR441_RS19265	COG0151	Belongs to the GarS family
JR441_RS19270	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS19275	COG1917	Cupin 2, conserved barrel domain protein
JR441_RS19280	COG0077	Prephenate dehydratase
JR441_RS19285	COG2814	Major facilitator Superfamily
JR441_RS19290	COG0833	amino acid
JR441_RS19295	COG4187	Peptidase family M20/M25/M40
JR441_RS19300	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS19305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JR441_RS19315	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
JR441_RS19320	COG1091	dTDP-4-dehydrorhamnose reductase activity
JR441_RS19325	COG1088	dTDP-glucose 4,6-dehydratase activity
JR441_RS19330	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JR441_RS19335	COG3980	spore coat polysaccharide biosynthesis protein
JR441_RS19340	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
JR441_RS19345	COG2089	acid synthase
JR441_RS19350	COG0456	acetyltransferase
JR441_RS19355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JR441_RS19360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JR441_RS19365	COG0463	Glycosyl transferase, family 2
JR441_RS19375	COG2363	Small membrane protein
JR441_RS19380	COG2233	PERMEase
JR441_RS19390	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS19395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JR441_RS19400	COG1216	Glycosyl transferase, family 2
JR441_RS19405	COG0351	phosphomethylpyrimidine kinase
JR441_RS19415	COG1621	beta-fructofuranosidase activity
JR441_RS19420	COG1263	PTS System
JR441_RS19420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS19425	COG2116	formate transmembrane transporter activity
JR441_RS19430	COG3711	transcriptional antiterminator
JR441_RS19440	COG1404	Belongs to the peptidase S8 family
JR441_RS19445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_RS19450	COG0778	Nitroreductase
JR441_RS19455	COG0772	Belongs to the SEDS family
JR441_RS19465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JR441_RS19470	COG1845	cytochrome c oxidase, subunit III
JR441_RS19475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JR441_RS19480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JR441_RS19485	COG2261	transglycosylase associated protein
JR441_RS19490	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JR441_RS19495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JR441_RS19500	COG2246	polysaccharide biosynthetic process
JR441_RS19505	COG1309	transcriptional regulator
JR441_RS19515	COG3162	membrane
JR441_RS19520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_RS19525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JR441_RS19530	COG2837	iron assimilation
JR441_RS19535	COG2822	iron ion transport
JR441_RS19540	COG0672	)-iron permease
JR441_RS19545	COG0352	thiamine-phosphate diphosphorylase activity
JR441_RS19550	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JR441_RS19555	COG0583	DNA-binding transcription factor activity
JR441_RS19560	COG1380	Effector of murein hydrolase LrgA
JR441_RS19565	COG1346	cytolysis
JR441_RS19570	COG2814	Major facilitator Superfamily
JR441_RS19575	COG4895	conserved protein (DUF2196)
JR441_RS19580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JR441_RS19585	COG0346	lactoylglutathione lyase activity
JR441_RS19595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_RS19600	COG1404	Belongs to the peptidase S8 family
JR441_RS19605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS19605	COG1263	PTS System
JR441_RS19610	COG3711	transcriptional antiterminator
JR441_RS19615	COG1442	glycosyl transferase family 8
JR441_RS19620	COG5522	Integral membrane protein (intg_mem_TP0381)
JR441_RS19625	COG1846	Transcriptional regulator
JR441_RS19630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JR441_RS19635	COG2234	aminopeptidase activity
JR441_RS19640	COG2357	RelA SpoT domain protein
JR441_RS19645	COG1575	Belongs to the MenA family. Type 1 subfamily
JR441_RS19660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_RS19665	COG1696	Membrane protein involved in D-alanine export
JR441_RS19670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_RS19675	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JR441_RS19680	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
JR441_RS19685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JR441_RS19690	COG1486	melibiose metabolic process
JR441_RS19695	COG1447	Phosphotransferase system cellobiose-specific component IIA
JR441_RS19700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_RS19705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_RS19710	COG3711	transcriptional antiterminator
JR441_RS19710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_RS19720	COG2094	Belongs to the DNA glycosylase MPG family
JR441_RS19725	COG0753	catalase activity
JR441_RS19730	COG2814	Major facilitator Superfamily
JR441_RS19735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
JR441_RS19740	COG1131	(ABC) transporter
JR441_RS19760	COG1595	DNA-templated transcription, initiation
JR441_RS19765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JR441_RS19770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JR441_RS19775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JR441_RS19780	COG4988	ABC transporter
JR441_RS19785	COG1294	oxidase, subunit
JR441_RS19790	COG1271	oxidase subunit
JR441_RS19795	COG3493	citrate carrier protein
JR441_RS19800	COG0501	Belongs to the peptidase M48B family
JR441_RS19810	COG0726	polysaccharide deacetylase
JR441_RS19815	COG3842	ATPase activity
JR441_RS19820	COG2508	Transcriptional regulator
JR441_RS19825	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS19830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_RS19840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JR441_RS19850	COG4585	Histidine kinase
JR441_RS19855	COG2197	response regulator
JR441_RS19860	COG2195	Cleaves the N-terminal amino acid of tripeptides
JR441_RS19870	COG4894	glucomannan catabolic process
JR441_RS19875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JR441_RS19880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JR441_RS19885	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS19890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JR441_RS19895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JR441_RS19900	COG2610	gluconate transmembrane transporter activity
JR441_RS19905	COG0500	methyltransferase
JR441_RS19910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JR441_RS19925	COG0753	catalase activity
JR441_RS19925	COG0693	protein deglycase activity
JR441_RS19930	COG2851	Citrate transporter
JR441_RS19935	COG2273	Hydrolase Family 16
JR441_RS19940	COG3711	transcriptional antiterminator
JR441_RS19950	COG2270	Major facilitator Superfamily
JR441_RS19955	COG0513	Belongs to the DEAD box helicase family
JR441_RS19960	COG2755	lipolytic protein G-D-S-L family
JR441_RS19960	COG3401	FG-GAP repeat protein
JR441_RS19985	COG0697	spore germination
JR441_RS19990	COG0589	response to stress
JR441_RS19995	COG2723	6-phospho-beta-galactosidase activity
JR441_RS20000	COG2190	(PTS) system
JR441_RS20000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_RS20000	COG1263	PTS System
JR441_RS20010	COG5444	nuclease activity
JR441_RS20025	COG3507	Belongs to the glycosyl hydrolase 43 family
JR441_RS20035	COG2986	histidine ammonia-lyase
JR441_RS20040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JR441_RS20045	COG1228	amidohydrolase
JR441_RS20050	COG0010	Belongs to the arginase family
JR441_RS20055	COG0833	amino acid
JR441_RS20060	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JR441_RS20065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JR441_RS20070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JR441_RS20075	COG2390	Transcriptional regulator
JR441_RS20085	COG3192	ethanolamine utilization protein
JR441_RS20090	COG2079	MmgE PrpD family protein
JR441_RS20095	COG1473	amidohydrolase
JR441_RS20100	COG1126	abc transporter atp-binding protein
JR441_RS20105	COG0765	amino acid transport
JR441_RS20110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_RS20115	COG0456	acetyltransferase
JR441_RS20120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_RS20130	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
JR441_RS20135	COG0561	phosphatase activity
JR441_RS20165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_RS20170	COG5294	Protein conserved in bacteria
JR441_RS20175	COG0577	efflux transmembrane transporter activity
JR441_RS20180	COG1136	(ABC) transporter
JR441_RS20185	COG2205	protein histidine kinase activity
JR441_RS20190	COG0745	RESPONSE REGULATOR receiver
JR441_RS20195	COG0191	fructose-bisphosphate aldolase activity
JR441_RS20200	COG1082	Xylose isomerase domain protein TIM barrel
JR441_RS20205	COG1082	Xylose isomerase domain protein TIM barrel
JR441_RS20210	COG0673	inositol 2-dehydrogenase activity
JR441_RS20215	COG2814	Major facilitator Superfamily
JR441_RS20220	COG1082	Xylose isomerase domain protein TIM barrel
JR441_RS20225	COG3962	Belongs to the TPP enzyme family
JR441_RS20230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_RS20240	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS20245	COG1349	DNA-binding transcription factor activity
JR441_RS20250	COG0667	Aldo Keto reductase
JR441_RS20265	COG2814	Major facilitator Superfamily
JR441_RS20270	COG0326	Molecular chaperone. Has ATPase activity
JR441_RS20280	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS20285	COG1309	transcriptional regulator
JR441_RS20290	COG1012	belongs to the aldehyde dehydrogenase family
JR441_RS20295	COG1714	RDD family
JR441_RS20300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JR441_RS20310	COG1714	RDD family
JR441_RS20315	COG2311	Membrane
JR441_RS20320	COG1917	Cupin 2, conserved barrel domain protein
JR441_RS20325	COG1309	transcriptional regulator
JR441_RS20330	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_RS20335	COG1846	Transcriptional regulator
JR441_RS20340	COG1380	Effector of murein hydrolase LrgA
JR441_RS20345	COG1346	cytolysis
JR441_RS20350	COG5039	Polysaccharide pyruvyl transferase
JR441_RS20355	COG1929	Belongs to the glycerate kinase type-1 family
JR441_RS20360	COG1802	Transcriptional regulator
JR441_RS20365	COG1070	Carbohydrate kinase
JR441_RS20370	COG2610	gluconate transmembrane transporter activity
JR441_RS20375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JR441_RS20380	COG0450	alkyl hydroperoxide reductase
JR441_RS20385	COG3634	alkyl hydroperoxide reductase activity
JR441_RS20395	COG2723	6-phospho-beta-galactosidase activity
JR441_RS20405	COG2188	Transcriptional regulator
JR441_RS20420	COG1131	(ABC) transporter
JR441_RS20425	COG1994	Peptidase M50
JR441_RS20430	COG0535	radical SAM domain protein
JR441_RS20440	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JR441_RS20460	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JR441_RS20475	COG1063	alcohol dehydrogenase
JR441_RS20495	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
JR441_RS20500	COG0456	acetyltransferase
JR441_RS20505	COG0457	Tetratricopeptide repeat
JR441_RS20515	COG0010	Belongs to the arginase family
JR441_RS20520	COG0833	amino acid
JR441_RS20525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JR441_RS20530	COG3829	transcription factor binding
JR441_RS20545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR441_RS20550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JR441_RS20555	COG4853	Protein conserved in bacteria
JR441_RS20560	COG4863	YycH protein
JR441_RS20565	COG5002	protein histidine kinase activity
JR441_RS20570	COG0745	RESPONSE REGULATOR receiver
JR441_RS20600	COG0346	lactoylglutathione lyase activity
JR441_RS20605	COG0305	Participates in initiation and elongation during chromosome replication
JR441_RS20620	COG3093	addiction module antidote protein HigA
JR441_RS20625	COG2807	transmembrane transport
JR441_RS20630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JR441_RS20635	COG0359	binds to the 23S rRNA
JR441_RS20640	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JR441_RS20645	COG4241	membrane
JR441_RS20655	COG5577	PFAM Coat F domain
JR441_RS20660	COG1733	regulation of RNA biosynthetic process
JR441_RS20665	COG1227	inorganic diphosphatase activity
JR441_RS20680	COG2271	Major facilitator Superfamily
JR441_RS20685	COG0789	Transcriptional regulator
JR441_RS20685	COG4978	Transcriptional regulator
JR441_RS20695	COG4319	ketosteroid isomerase
JR441_RS20700	COG1357	PFAM Pentapeptide repeats (8 copies)
JR441_RS20705	COG2814	Major facilitator Superfamily
JR441_RS20710	COG0583	DNA-binding transcription factor activity
JR441_RS20715	COG2153	protein acetylation
JR441_RS20725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_RS20730	COG1846	Transcriptional regulator
JR441_RS20735	COG2153	protein acetylation
JR441_RS20740	COG2364	Membrane
JR441_RS20745	COG0456	acetyltransferase
JR441_RS20750	COG2315	Protein conserved in bacteria
JR441_RS20755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JR441_RS20765	COG2814	Major facilitator Superfamily
JR441_RS20775	COG1331	Highly conserved protein containing a thioredoxin domain
JR441_RS20780	COG0789	Transcriptional regulator
JR441_RS20785	COG0697	spore germination
JR441_RS20790	COG1331	Highly conserved protein containing a thioredoxin domain
JR441_RS20795	COG1266	CAAX protease self-immunity
JR441_RS20800	COG2814	Major facilitator Superfamily
JR441_RS20800	COG0477	Major facilitator Superfamily
JR441_RS20805	COG0110	maltose O-acetyltransferase activity
JR441_RS20810	COG0346	lactoylglutathione lyase activity
JR441_RS20815	COG1609	Transcriptional regulator
JR441_RS20820	COG0708	Exodeoxyribonuclease III
JR441_RS20825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JR441_RS20830	COG0629	single-stranded DNA binding
JR441_RS20835	COG0360	Binds together with S18 to 16S ribosomal RNA
JR441_RS20840	COG0012	GTP binding
JR441_RS20845	COG0243	molybdopterin cofactor binding
JR441_RS20850	COG4481	Protein conserved in bacteria
JR441_RS20855	COG3949	Membrane
JR441_RS20865	COG1475	DNA binding
JR441_RS20870	COG1192	Involved in chromosome partitioning
JR441_RS20880	COG1475	DNA binding
JR441_RS20885	COG0357	Ribosomal RNA small subunit methyltransferase G
JR441_RS20890	COG0445	tRNA wobble uridine modification
JR441_RS20895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JR441_RS20900	COG1847	R3H domain protein
JR441_RS20905	COG0706	membrane insertase activity
JR441_RS20910	COG0594	ribonuclease P activity