locus-tag class description DAE22_RS00010 ENOG4105KBK Zinc finger, swim domain protein DAE22_RS00020 ENOG4105HTX biosynthesis protein DAE22_RS00025 ENOG4107YJ4 chain length determinant protein DAE22_RS00030 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DAE22_RS00035 ENOG4105C6Y Udp-glucose 6-dehydrogenase DAE22_RS00070 ENOG4107V2S Transcriptional regulator DAE22_RS00075 ENOG4108WS4 fmn reductase DAE22_RS00085 ENOG4105FGV Chromate DAE22_RS00090 ENOG4105CAH Chromate DAE22_RS00100 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DAE22_RS00110 ENOG4107XC4 flavin reductase domain protein, FMN-binding DAE22_RS00125 ENOG4107RSM transcriptional regulator DAE22_RS00135 ENOG4107FQX Alpha-acetolactate decarboxylase DAE22_RS00140 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DAE22_RS00155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DAE22_RS00160 ENOG4105CNN ABC, transporter DAE22_RS00165 ENOG4105C2J ABC transporter DAE22_RS00170 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DAE22_RS00175 ENOG4108RVA ribokinase DAE22_RS00180 ENOG4105ETE Transcriptional regulator (LacI family DAE22_RS00185 ENOG4105N98 Capsule biosynthesis protein capB DAE22_RS00195 ENOG4105PNM synthesis protein DAE22_RS00205 ENOG4105K4H Nlp p60 protein DAE22_RS00210 ENOG4105J7I hydrolase DAE22_RS00215 ENOG4108KGH TRANSCRIPTIONal DAE22_RS00220 ENOG4105C54 Major Facilitator superfamily DAE22_RS00225 ENOG4108NHD germination protein DAE22_RS00240 ENOG4105DG6 mannose-6-phosphate isomerase DAE22_RS00280 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase DAE22_RS00290 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DAE22_RS00300 ENOG4107SJB teichoic acid biosynthesis DAE22_RS00305 ENOG4105CPF Cell wall formation (By similarity) DAE22_RS00325 ENOG4105EY8 ABC transporter DAE22_RS00330 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DAE22_RS00350 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DAE22_RS00365 ENOG4105JFG SpoIID LytB domain protein DAE22_RS00370 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DAE22_RS00380 ENOG4105D3Q Sugar transferase DAE22_RS00385 ENOG4105PSV Polysaccharide Biosynthesis Protein DAE22_RS00390 ENOG4107RA4 Glycosyl transferase (Group 1 DAE22_RS00395 ENOG4105C6Y Udp-glucose 6-dehydrogenase DAE22_RS00400 ENOG4105QZI O-Antigen Polymerase DAE22_RS00415 ENOG4107EF8 Glycosyl transferase (Group 1 DAE22_RS00420 ENOG4105ESV Glycosyl transferase, family 4 DAE22_RS00425 ENOG4108KGH TRANSCRIPTIONal DAE22_RS00430 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DAE22_RS00435 ENOG4105BZU Histidine kinase DAE22_RS00440 ENOG4105WH1 Two component transcriptional regulator luxr family DAE22_RS00460 ENOG41081UC Inherit from COG: Competence protein DAE22_RS00465 ENOG4105RU3 DAE22_RS00480 ENOG4105E1Q flagellar hook-associated protein DAE22_RS00485 ENOG4105DTJ flagellar hook-associated protein DAE22_RS00490 ENOG4105MKD DAE22_RS00495 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) DAE22_RS00500 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DAE22_RS00505 ENOG4105I03 Flagellin DAE22_RS00510 ENOG41083S7 flagellar protein FlaG DAE22_RS00515 ENOG4107RT6 flagellar hook-associated DAE22_RS00520 ENOG4105MQ3 flagellar protein FliS DAE22_RS00535 ENOG4105MS2 ribosomal subunit Interface protein DAE22_RS00560 ENOG4105CAK Cell division ATP-binding protein ftsE DAE22_RS00565 ENOG4105CRP Part of the ABC transporter FtsEX involved in DAE22_RS00570 ENOG4105CN1 protease DAE22_RS00590 ENOG4105MKU Transcriptional regulator DAE22_RS00610 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DAE22_RS00615 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DAE22_RS00620 ENOG4105I03 Flagellin DAE22_RS00635 ENOG4108PY7 DAE22_RS00640 ENOG41067S9 phage shock protein C, PspC DAE22_RS00645 ENOG41086DT Membrane protein of unknown function DAE22_RS00665 ENOG41088CQ domain protein DAE22_RS00675 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DAE22_RS00680 ENOG4105CE4 GlcNAc 6-P deacetylase DAE22_RS00685 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) DAE22_RS00690 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DAE22_RS00695 ENOG4105HKU nucleoside recognition domain-containing protein DAE22_RS00700 ENOG4107XGZ Hydrolase DAE22_RS00705 ENOG4108S4C acetyltransferase DAE22_RS00710 ENOG4108E16 pectate lyase DAE22_RS00720 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DAE22_RS00725 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DAE22_RS00730 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DAE22_RS00735 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DAE22_RS00740 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DAE22_RS00745 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DAE22_RS00750 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DAE22_RS00755 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DAE22_RS00775 ENOG4105BZ1 (ABC) transporter DAE22_RS00790 ENOG4105C3M thioredoxin reductase DAE22_RS00795 ENOG4108Z4K mutator MutT protein DAE22_RS00800 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DAE22_RS00805 ENOG4105CHW UPF0052 protein DAE22_RS00810 ENOG4105CIE May be required for sporulation (By similarity) DAE22_RS00815 ENOG4105KRI phosphocarrier protein (HPr DAE22_RS00820 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DAE22_RS00825 ENOG4107A6P DAE22_RS00835 ENOG4105EWM Histidine kinase DAE22_RS00840 ENOG4105C19 ABC transporter DAE22_RS00850 ENOG4105C5I Dehydrogenase DAE22_RS00855 ENOG4108V2W Carbonate dehydratase DAE22_RS00860 ENOG4105CHH sulfate transporter DAE22_RS00865 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain DAE22_RS00870 ENOG4108URH decarboxylase DAE22_RS00875 ENOG4105FKQ transcriptional regulator DAE22_RS00880 ENOG4108IUK alpha amylase, catalytic DAE22_RS00885 ENOG4107FKK extracellular solute-binding protein family 1 DAE22_RS00890 ENOG4105D56 permease protein DAE22_RS00895 ENOG4105EG2 ABC transporter, permease DAE22_RS00910 ENOG4105CG3 alpha amylase, catalytic region DAE22_RS00915 ENOG4107URF beta-phospho-glucomutase DAE22_RS00920 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DAE22_RS00950 ENOG4107QTZ amino acid DAE22_RS00955 ENOG4108HKT sucrose-6-phosphate hydrolase DAE22_RS00960 ENOG4105EDQ levansucrase EC 2.4.1.10 DAE22_RS00970 ENOG4105FQP Beta-lactamase DAE22_RS00980 ENOG4105NI3 Protein of unknown function (DUF3237) DAE22_RS00985 ENOG4105PY6 Phenolic acid decarboxylase DAE22_RS00995 ENOG4105EBR Carboxylesterase DAE22_RS01005 ENOG4105HTX biosynthesis protein DAE22_RS01010 ENOG4108QV3 biosynthesis protein DAE22_RS01020 ENOG4108PQP glycosyl transferase group 1 DAE22_RS01025 ENOG4105K64 Glycosyl transferase, family 2 DAE22_RS01030 ENOG4108KMV Glycosyl transferase (Group 1 DAE22_RS01035 ENOG41068W6 Capsular polysaccharide biosynthesis protein DAE22_RS01040 ENOG4107QRS glycosyltransferase group 2 family protein DAE22_RS01050 ENOG4105K64 Glycosyl transferase, family 2 DAE22_RS01060 ENOG4105D3Q Sugar transferase DAE22_RS01065 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family DAE22_RS01070 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DAE22_RS01075 ENOG4108ZPC Polysaccharide pyruvyl transferase DAE22_RS01085 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DAE22_RS01090 ENOG4105DAA L-lactate DAE22_RS01095 ENOG4105JXH GntR family transcriptional regulator DAE22_RS01105 ENOG4107FKK extracellular solute-binding protein family 1 DAE22_RS01115 ENOG4105EG2 ABC transporter, permease DAE22_RS01130 ENOG4108MJI response regulator DAE22_RS01135 ENOG4107R6F Alpha Beta Hydrolase Fold protein DAE22_RS01140 ENOG4108M15 ABC transporter DAE22_RS01145 ENOG4105KCT ABC transporter DAE22_RS01150 ENOG4105BZU Histidine kinase DAE22_RS01160 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DAE22_RS01165 ENOG4107QR9 Iron-sulfur cluster binding protein DAE22_RS01170 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) DAE22_RS01175 ENOG4105VRS hydrolase family 18 DAE22_RS01185 ENOG4107RT3 EamA-like transporter family DAE22_RS01190 ENOG4105GZI Transcriptional regulator DAE22_RS01195 ENOG4105DEN Luciferase family DAE22_RS01200 ENOG4105CMD Transcriptional regulator, GntR family DAE22_RS01215 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DAE22_RS01220 ENOG4105BZA Phosphoglycerate kinase DAE22_RS01225 ENOG4105CP7 Triose-phosphate isomerase DAE22_RS01230 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DAE22_RS01235 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DAE22_RS01240 ENOG4108W0I acetyltransferase DAE22_RS01245 ENOG4105T65 Membrane-associated protein DAE22_RS01255 ENOG4108QCI YvbH-like oligomerisation region DAE22_RS01260 ENOG4107HG4 Transcriptional regulator DAE22_RS01265 ENOG4108IJ8 ABC transporter DAE22_RS01270 ENOG4105E90 ABC transporter DAE22_RS01275 ENOG4108HQR Glycine betaine DAE22_RS01280 ENOG4105R40 Glycine betaine carnitine choline DAE22_RS01285 ENOG4107HG4 Transcriptional regulator DAE22_RS01290 ENOG4108IJ8 ABC transporter DAE22_RS01295 ENOG4105E90 ABC transporter DAE22_RS01300 ENOG4108HQR Glycine betaine DAE22_RS01305 ENOG4105R40 Glycine betaine carnitine choline DAE22_RS01310 ENOG4105C8Q Methyl-accepting chemotaxis DAE22_RS01315 ENOG4105KVH Transcriptional regulator DAE22_RS01340 ENOG4105XZU Preprotein translocase, subunit SecG DAE22_RS01350 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DAE22_RS01355 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DAE22_RS01375 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DAE22_RS01380 ENOG4105KBX Transcriptional regulator, TetR family DAE22_RS01385 ENOG4105KPY Small multidrug resistance protein DAE22_RS01390 ENOG4105RXJ DAE22_RS01400 ENOG4105ME7 Membrane DAE22_RS01405 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DAE22_RS01410 ENOG4105D9R oxidoreductase DAE22_RS01415 ENOG4105VPX protein, conserved in bacteria DAE22_RS01420 ENOG410681U heavy metal transport detoxification protein DAE22_RS01425 ENOG4105C59 p-type ATPase DAE22_RS01430 ENOG4105C59 p-type ATPase DAE22_RS01435 ENOG4107ZQN disulfide bond DAE22_RS01445 ENOG4105EN6 Membrane DAE22_RS01450 ENOG4105EEM helicase DAE22_RS01455 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DAE22_RS01460 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DAE22_RS01465 ENOG4105EEQ Na H antiporter DAE22_RS01480 ENOG4105E0C molybdate abc transporter DAE22_RS01485 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DAE22_RS01490 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DAE22_RS01495 ENOG4107QZ2 Sulfatase DAE22_RS01500 ENOG4107K5X Membrane-bound metal-dependent hydrolase DAE22_RS01510 ENOG4105D5Q Arginine ornithine antiporter DAE22_RS01525 ENOG4105WAB arsR family transcriptional regulator DAE22_RS01535 ENOG4105DQ5 transport system permease protein DAE22_RS01540 ENOG4105EHG Permease protein DAE22_RS01545 ENOG4105E0A ABC, transporter DAE22_RS01550 ENOG4108WMK Efflux transporter RND family MFP subunit DAE22_RS01555 ENOG4105C19 ABC transporter DAE22_RS01560 ENOG4107RBB ABC transporter, permease DAE22_RS01570 ENOG4105F0F Oxalate decarboxylase DAE22_RS01580 ENOG4106DF4 Sigma-70, region 4 DAE22_RS01590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DAE22_RS01600 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DAE22_RS01605 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DAE22_RS01610 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DAE22_RS01615 ENOG4105EHG Permease protein DAE22_RS01620 ENOG4105E0A ABC, transporter DAE22_RS01625 ENOG4108WBT adenosyltransferase DAE22_RS01640 ENOG41087YS Phage shock protein A DAE22_RS01655 ENOG4105ENE Histidine kinase DAE22_RS01660 ENOG4105WH1 Two component transcriptional regulator luxr family DAE22_RS01685 ENOG4105C9Q fumarate hydratase class II DAE22_RS01690 ENOG41067SE Tetr family transcriptional regulator DAE22_RS01700 ENOG4105F3H Histidine kinase DAE22_RS01710 ENOG4105C0H protease DAE22_RS01715 ENOG4105HUF DNA protection during starvation protein DAE22_RS01720 ENOG4105E1F short-chain dehydrogenase reductase DAE22_RS01735 ENOG4105E0A ABC, transporter DAE22_RS01745 ENOG4105EGI Transcriptional regulator DAE22_RS01755 ENOG4105MDS 4-oxalocrotonate tautomerase DAE22_RS01760 ENOG4105C0R drug resistance transporter emrb qaca subfamily DAE22_RS01765 ENOG41067TZ transcriptional regulator, MarR family DAE22_RS01795 ENOG4105CHU acetyl-coa acetyltransferase DAE22_RS01800 ENOG4105C1G acyl-Coa dehydrogenase DAE22_RS01805 ENOG41080E8 Transcriptional regulator, Spx MgsR family DAE22_RS01810 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DAE22_RS01835 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DAE22_RS01840 ENOG4108UMI ABC transporter, permease DAE22_RS01845 ENOG4105D01 (LipO)protein DAE22_RS01860 ENOG4105C3K feS assembly ATPase SufC DAE22_RS01865 ENOG4105JRK feS assembly protein SufD DAE22_RS01870 ENOG4105C9B Cysteine desulfurase DAE22_RS01875 ENOG4108UNV SUF system FeS assembly protein, NifU family DAE22_RS01880 ENOG4105DIW FeS assembly protein SUFB DAE22_RS01885 ENOG4105NPE arsR family transcriptional regulator DAE22_RS01905 ENOG4107VFR oxidoreductase DAE22_RS01910 ENOG4105PKS Excinuclease abc c subunit domain protein DAE22_RS01915 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine DAE22_RS01920 ENOG4105XN3 extracellular solute-binding protein family 1 DAE22_RS01925 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DAE22_RS01930 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DAE22_RS01935 ENOG4108KPW sugar kinase DAE22_RS01940 ENOG4105FDP GntR family transcriptional regulator DAE22_RS01945 ENOG4108IJ9 (ABC) transporter DAE22_RS01950 ENOG4108K8S endonuclease I DAE22_RS01965 ENOG4105C5R Aminotransferase DAE22_RS01970 ENOG4105XRQ Xanthine dehydrogenase accessory factor DAE22_RS01985 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding DAE22_RS01990 ENOG4107YV9 domain protein DAE22_RS02020 ENOG4105VT2 5-hydroxyisourate hydrolase DAE22_RS02025 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) DAE22_RS02040 ENOG4105G9B Transcriptional regulator DAE22_RS02045 ENOG4105CD3 dihydroorotase DAE22_RS02055 ENOG4105I3N Conserved Protein DAE22_RS02065 ENOG4107R8B 5'-nucleotidase DAE22_RS02070 ENOG4105KZD Domain of unknown function (DUF1805) DAE22_RS02075 ENOG4108YTE sporulation protein YunB DAE22_RS02080 ENOG4105FAA peptidase M23 DAE22_RS02085 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DAE22_RS02090 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DAE22_RS02095 ENOG4105MMD transcriptional regulator DAE22_RS02105 ENOG4105D4U had-superfamily hydrolase, subfamily iia DAE22_RS02110 ENOG4108W5N phosphatidylglycerophosphatase a DAE22_RS02120 ENOG4105D6E homoserine dehydrogenase DAE22_RS02125 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DAE22_RS02130 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DAE22_RS02135 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DAE22_RS02140 ENOG41083MR nifu domain-containing protein DAE22_RS02155 ENOG4105ZKE UPF0349 protein DAE22_RS02170 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DAE22_RS02175 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DAE22_RS02195 ENOG4105CAY ferredoxin--nadp reductase DAE22_RS02200 ENOG4105CEP NADH dehydrogenase DAE22_RS02215 ENOG41069ER domain protein DAE22_RS02225 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DAE22_RS02245 ENOG4105NIV Esterase DAE22_RS02250 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DAE22_RS02255 ENOG4105E4F Isochorismate synthase DAE22_RS02260 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DAE22_RS02265 ENOG4105WQI isochorismatase DAE22_RS02270 ENOG4105CEY Amp-dependent synthetase and ligase DAE22_RS02275 ENOG4105WQT MbtH domain protein DAE22_RS02285 ENOG4105DCF alanine dehydrogenase DAE22_RS02290 ENOG4108K8K Transcriptional regulator DAE22_RS02325 ENOG410904N short-chain dehydrogenase reductase DAE22_RS02345 ENOG4105C02 permease DAE22_RS02370 ENOG4105DAP Nicotinate phosphoribosyltransferase DAE22_RS02375 ENOG4105D58 Diguanylate phosphodiesterase DAE22_RS02405 ENOG4105BZU Histidine kinase DAE22_RS02415 ENOG4105KA0 thioesterase Superfamily protein DAE22_RS02420 ENOG4105KJM monovalent cation h antiporter subunit g DAE22_RS02430 ENOG4105SC1 monovalent cation H antiporter subunit E DAE22_RS02435 ENOG4108JPZ Monovalent cation H antiporter subunit D DAE22_RS02440 ENOG4108ZE9 Monovalent cation H antiporter subunit C DAE22_RS02445 ENOG4105HC0 Na H antiporter DAE22_RS02450 ENOG4105D65 subunit l DAE22_RS02470 ENOG4105UIB (ABC) transporter DAE22_RS02475 ENOG4108JQ9 ABC transporter DAE22_RS02480 ENOG4105DIH basic membrane DAE22_RS02485 ENOG4108MRH transcriptional regulatory protein DAE22_RS02500 ENOG4105KIR Thiol-disulfide oxidoreductase dcc DAE22_RS02505 ENOG4105BZ4 penicillin-binding protein DAE22_RS02520 ENOG4105Y38 Kinase-associated protein B DAE22_RS02525 ENOG4108HGU Histidine kinase DAE22_RS02530 ENOG4105C87 Aminotransferase class I and II DAE22_RS02540 ENOG4108MUZ hydrolase DAE22_RS02545 ENOG4108ZB6 transcriptional regulator AsnC family DAE22_RS02550 ENOG4105CHM Aminotransferase DAE22_RS02560 ENOG4105WG9 Conserved Protein DAE22_RS02565 ENOG4107QW4 alcohol dehydrogenase DAE22_RS02575 ENOG4107QYV phosphohexose isomerase DAE22_RS02590 ENOG4107PBV potassium channel DAE22_RS02595 ENOG4107PBV potassium channel DAE22_RS02610 ENOG4105C37 (CBS) domain DAE22_RS02620 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme DAE22_RS02625 ENOG4105EA8 2-Nitropropane dioxygenase DAE22_RS02640 ENOG4105C8Q Methyl-accepting chemotaxis DAE22_RS02650 ENOG4105C8Q Methyl-accepting chemotaxis DAE22_RS02655 ENOG4105C8Q Methyl-accepting chemotaxis DAE22_RS02665 ENOG4105E98 transcriptional regulator DeoR family DAE22_RS02670 ENOG4105DET Rhamnulokinase DAE22_RS02675 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) DAE22_RS02680 ENOG4105DKG l-rhamnose isomerase DAE22_RS02685 ENOG4105EE0 oxidoreductase DAE22_RS02695 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DAE22_RS02715 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DAE22_RS02720 ENOG4107I77 yiaA/B two helix domain DAE22_RS02725 ENOG4105CZN Potassium uptake protein DAE22_RS02740 ENOG4105TRT Transcriptional regulator DAE22_RS02750 ENOG4108JB8 alcohol dehydrogenase DAE22_RS02755 ENOG4108VNY MOSC domain protein DAE22_RS02760 ENOG4106DF1 DAE22_RS02770 ENOG4105DZ6 Band 7 protein DAE22_RS02775 ENOG4105VRR gCN5-related N-acetyltransferase DAE22_RS02780 ENOG4105N67 Proton-coupled thiamine transporter YuaJ DAE22_RS02910 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DAE22_RS02920 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DAE22_RS02940 ENOG4105E4F Isochorismate synthase DAE22_RS02945 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DAE22_RS02950 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DAE22_RS02955 ENOG4108IPT Naphthoate synthase DAE22_RS02960 ENOG4105CEY Amp-dependent synthetase and ligase DAE22_RS02965 ENOG4105DTQ mandelate racemase muconate lactonizing DAE22_RS02970 ENOG4105DSE periplasmic solute binding protein DAE22_RS02975 ENOG4105DIK (ABC) transporter DAE22_RS02980 ENOG4105CC5 ABC transporter DAE22_RS02985 ENOG4105CC5 ABC transporter DAE22_RS03010 ENOG4108V2W Carbonate dehydratase DAE22_RS03015 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DAE22_RS03020 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DAE22_RS03035 ENOG4108RMU ferritin dps family protein DAE22_RS03050 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DAE22_RS03060 ENOG4105D2X ABC transporter substrate-binding protein DAE22_RS03075 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DAE22_RS03080 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DAE22_RS03085 ENOG4105CAQ asparagine synthetase DAE22_RS03090 ENOG4105C85 amino acid DAE22_RS03095 ENOG4108Z0R Transferase DAE22_RS03100 ENOG4105E8V Alpha Beta Hydrolase Fold protein DAE22_RS03115 ENOG4105N5T Radical SAM Protein DAE22_RS03130 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DAE22_RS03135 ENOG4105DVE abc transporter atp-binding protein DAE22_RS03150 ENOG4105C19 ABC transporter DAE22_RS03155 ENOG4107R34 abc transporter permease protein DAE22_RS03165 ENOG4105EWM Histidine kinase DAE22_RS03170 ENOG4105C19 ABC transporter DAE22_RS03180 ENOG4106UBQ DAE22_RS03185 ENOG410605W Major Facilitator DAE22_RS03190 ENOG4105BZU Histidine kinase DAE22_RS03200 ENOG4105C8T Leucyl-tRNA synthetase DAE22_RS03205 ENOG41085GJ domain protein DAE22_RS03235 ENOG4105NTD Inherit from COG: Hydrolase DAE22_RS03245 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) DAE22_RS03250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DAE22_RS03255 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DAE22_RS03265 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DAE22_RS03270 ENOG4106A3M Cytochrome p-450 DAE22_RS03280 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DAE22_RS03290 ENOG41075H3 AraC family transcriptional regulator DAE22_RS03300 ENOG4105F5H Glycosyl Hydrolase Family 88 DAE22_RS03310 ENOG4105DDC Oxidoreductase domain protein DAE22_RS03315 ENOG4105MU9 integral membrane protein DAE22_RS03325 ENOG4105C94 Transporter DAE22_RS03330 ENOG4105CBX hi0933 family DAE22_RS03345 ENOG4105YW5 deoR family transcriptional regulator DAE22_RS03360 ENOG4105C7N Xanthine uracil vitamin C permease DAE22_RS03365 ENOG4107QSE Dipeptidase DAE22_RS03370 ENOG4105C6T cysteine synthase DAE22_RS03375 ENOG4107F58 2'-5' rna ligase DAE22_RS03390 ENOG4108IUM Glycogen debranching enzyme DAE22_RS03395 ENOG4108V15 phosphotransferase enzyme family DAE22_RS03405 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DAE22_RS03410 ENOG4105C8F Beta-lactamase domain protein DAE22_RS03415 ENOG4105C6K Malic enzyme DAE22_RS03430 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ DAE22_RS03450 ENOG4108VDD TRNA binding domain protein DAE22_RS03460 ENOG4105DFU Cell wall formation (By similarity) DAE22_RS03480 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DAE22_RS03485 ENOG4105ETE Transcriptional regulator (LacI family DAE22_RS03490 ENOG4107R0U MotA TolQ exbB proton channel DAE22_RS03495 ENOG4105ER2 Ompa motb domain protein DAE22_RS03500 ENOG4105DGU Histone deacetylase DAE22_RS03505 ENOG4105W87 Cbs domain DAE22_RS03510 ENOG4105F1V Acetoin utilization protein DAE22_RS03520 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DAE22_RS03525 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DAE22_RS03530 ENOG4105BZU Histidine kinase DAE22_RS03540 ENOG4105U5Y Transcriptional regulator DAE22_RS03575 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DAE22_RS03580 ENOG4105EFZ amidohydrolase DAE22_RS03585 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DAE22_RS03590 ENOG4105D07 Signal peptide peptidase, SppA DAE22_RS03595 ENOG4105VK3 rdd domain containing protein DAE22_RS03605 ENOG4105KBJ sporulation protein ytfj DAE22_RS03610 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DAE22_RS03620 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DAE22_RS03625 ENOG4105EPU Molybdenum cofactor synthesis domain protein DAE22_RS03630 ENOG4105CDH Citrulline--aspartate ligase DAE22_RS03635 ENOG4105CH7 arginosuccinase DAE22_RS03645 ENOG4105E8R UPF0173 metal-dependent hydrolase DAE22_RS03650 ENOG4108KSA LysR family transcriptional regulator DAE22_RS03655 ENOG4108XSB acetyltransferase, (GNAT) family DAE22_RS03680 ENOG4105CDA abc transporter atp-binding protein DAE22_RS03685 ENOG4105DEN Luciferase family DAE22_RS03705 ENOG4105CH2 amidohydrolase DAE22_RS03710 ENOG410635A Membrane DAE22_RS03725 ENOG4105SFS phosphoesterase RecJ domain protein DAE22_RS03730 ENOG4106EVM DAE22_RS03740 ENOG4105VV2 DAE22_RS03745 ENOG4105C0B DNA polymerase III (alpha subunit) DAE22_RS03750 ENOG4105C6K Malic enzyme DAE22_RS03755 ENOG4108IEY Carboxyl transferase domain DAE22_RS03765 ENOG4105CTQ phosphohexokinase DAE22_RS03770 ENOG4105CA9 Pyruvate kinase DAE22_RS03775 ENOG4105FS0 cytoplasmic membrane protein DAE22_RS03780 ENOG4108REF Sporulation integral membrane protein ytvi DAE22_RS03790 ENOG4105BZN citrate synthase DAE22_RS03795 ENOG4108HMX isocitrate dehydrogenase (NADP) DAE22_RS03800 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DAE22_RS03805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DAE22_RS03810 ENOG4105BZU Histidine kinase DAE22_RS03815 ENOG4105C2M dna polymerase I DAE22_RS03820 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DAE22_RS03830 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DAE22_RS03835 ENOG4105CV8 reductase DAE22_RS03840 ENOG4105F27 Major Facilitator DAE22_RS03845 ENOG4105KVH Transcriptional regulator DAE22_RS03850 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DAE22_RS03855 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DAE22_RS03860 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DAE22_RS03880 ENOG4108TDW sporulation protein YtxC DAE22_RS03885 ENOG4105C22 threonyL-tRNA synthetase DAE22_RS03895 ENOG4108HRK Histidine kinase DAE22_RS03900 ENOG4105DY9 regulatoR DAE22_RS03910 ENOG41067MG lrgb family DAE22_RS03920 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DAE22_RS03925 ENOG4105VJV 50s ribosomal protein L35 DAE22_RS03930 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DAE22_RS03935 ENOG410696E Membrane DAE22_RS03945 ENOG4105CN9 Peptidase m42 family protein DAE22_RS03950 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase DAE22_RS03960 ENOG4105EF1 ribulokinase DAE22_RS03965 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase DAE22_RS03975 ENOG4108MDK Dehydrogenase DAE22_RS03990 ENOG4105DRS transport system, permease DAE22_RS03995 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DAE22_RS04000 ENOG4105K7K Transcriptional regulator DAE22_RS04025 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DAE22_RS04030 ENOG4105CQB FAD linked oxidase domain protein DAE22_RS04040 ENOG41067MF small acid-soluble spore protein DAE22_RS04045 ENOG4108RWN rrna methyltransferase DAE22_RS04055 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DAE22_RS04060 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DAE22_RS04065 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DAE22_RS04080 ENOG4105DCG PHP domain protein DAE22_RS04085 ENOG4105C98 muts2 protein DAE22_RS04095 ENOG4105CEY Amp-dependent synthetase and ligase DAE22_RS04100 ENOG4107Z3H Transcriptional regulator, TetR family DAE22_RS04105 ENOG41060WC Enoyl-CoA hydratase DAE22_RS04110 ENOG4105BZJ Electron transfer flavoprotein DAE22_RS04115 ENOG4105C10 Electron transfer flavoprotein DAE22_RS04120 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DAE22_RS04125 ENOG4105K63 Thioredoxin DAE22_RS04130 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DAE22_RS04135 ENOG4105CFH Aspartokinase DAE22_RS04145 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DAE22_RS04155 ENOG4105E33 succinate dehydrogenase DAE22_RS04165 ENOG4105PFC Transcriptional regulator DAE22_RS04170 ENOG41067TZ transcriptional regulator, MarR family DAE22_RS04175 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DAE22_RS04180 ENOG4108XJQ germination protein DAE22_RS04185 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DAE22_RS04190 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DAE22_RS04195 ENOG4105M59 Phosphodiesterase, mj0936 family DAE22_RS04205 ENOG4107KM7 Heat induced stress protein YflT DAE22_RS04210 ENOG4105I4A GCN5-related N-acetyltransferase DAE22_RS04220 ENOG4105C7K acetolactate synthase DAE22_RS04225 ENOG4108ZP8 Acetolactate synthase small subunit DAE22_RS04230 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DAE22_RS04235 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DAE22_RS04240 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DAE22_RS04245 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DAE22_RS04250 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DAE22_RS04260 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DAE22_RS04265 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DAE22_RS04270 ENOG4108IUQ atp-dependent protease DAE22_RS04275 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DAE22_RS04280 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DAE22_RS04290 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DAE22_RS04300 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DAE22_RS04310 ENOG4105D52 delta-aminolevulinic acid dehydratase DAE22_RS04315 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DAE22_RS04320 ENOG41068KH stage VI sporulation protein D DAE22_RS04325 ENOG4106AR7 Spore coat protein DAE22_RS04335 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DAE22_RS04340 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DAE22_RS04345 ENOG4106A3R peptidase DAE22_RS04355 ENOG4108Z03 MAF-like protein DAE22_RS04360 ENOG4105W5Q DNA repair protein (RadC DAE22_RS04365 ENOG4108C33 Resolvase DAE22_RS04540 ENOG4108FKH Transglycosylase SLT domain DAE22_RS04550 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DAE22_RS04555 ENOG410651K Teichoic acid biosynthesis protein C DAE22_RS04570 ENOG41068G1 DAE22_RS04595 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DAE22_RS04600 ENOG4106ANW SMI1_KNR4 DAE22_RS04605 ENOG4106BHF DAE22_RS04610 ENOG410780I phosphoprotein phosphatase activity DAE22_RS04650 ENOG4105DFF Rod shape-determining protein mreb DAE22_RS04660 ENOG4105YHC Rod shape-determining protein MreD DAE22_RS04665 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DAE22_RS04670 ENOG4107QMS site-determining protein DAE22_RS04685 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DAE22_RS04690 ENOG4105X36 (ribosomal) protein DAE22_RS04695 ENOG4105K46 50S ribosomal protein l27 DAE22_RS04710 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DAE22_RS04715 ENOG41090I5 UPF0735 ACT domain-containing protein DAE22_RS04720 ENOG4105CQC Prephenate dehydratase DAE22_RS04735 ENOG4108IYU L-aspartate oxidase DAE22_RS04740 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DAE22_RS04745 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DAE22_RS04750 ENOG4106678 morphogenetic protein associated with SpoVID DAE22_RS04760 ENOG4105CDY transcriptional regulatory protein DAE22_RS04765 ENOG4105BZG amino acid carrier protein DAE22_RS04790 ENOG4105CK5 oxidoreductase DAE22_RS04795 ENOG4105IE8 Alpha-ketoglutarate permease DAE22_RS04805 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DAE22_RS04810 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DAE22_RS04815 ENOG41061AI Protein of unknown function (DUF2905) DAE22_RS04820 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DAE22_RS04825 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DAE22_RS04830 ENOG4105VIE preprotein translocase, subunit YajC DAE22_RS04835 ENOG4105NAP DAE22_RS04840 ENOG4108QG2 Membrane DAE22_RS04845 ENOG4105CKP Polysaccharide Biosynthesis Protein DAE22_RS04855 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DAE22_RS04860 ENOG4105NCW Trka-c domain protein DAE22_RS04865 ENOG41067VP Protein of unknown function (DUF1049) DAE22_RS04870 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DAE22_RS04875 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DAE22_RS04880 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DAE22_RS04890 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DAE22_RS04900 ENOG4105CUT histidyl-tRNA synthetase DAE22_RS04905 ENOG4105C9M aspartyl-trna synthetase DAE22_RS04915 ENOG4105CUZ uba thif-type nad fad binding protein DAE22_RS04920 ENOG4105D1H recombination factor protein RarA DAE22_RS04930 ENOG4105C3J Cysteine desulfurase DAE22_RS04935 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DAE22_RS04945 ENOG4105C7H Helicase, RecD TraA family DAE22_RS04955 ENOG41060CR DAE22_RS04965 ENOG4105DRP amino acid AbC transporter DAE22_RS04970 ENOG4105EAD ABC transporter DAE22_RS04975 ENOG4105CT1 (ABC) transporter DAE22_RS04980 ENOG4105CDA abc transporter atp-binding protein DAE22_RS04985 ENOG4105C02 permease DAE22_RS04990 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DAE22_RS04995 ENOG4105VBH UPF0297 protein DAE22_RS05000 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DAE22_RS05005 ENOG4105VPH UPF0473 protein DAE22_RS05010 ENOG4105HHA aminodeoxychorismate lyase DAE22_RS05020 ENOG4105XYU peptidase (U32 family) DAE22_RS05025 ENOG4105CFP Peptidase U32 DAE22_RS05030 ENOG4105DBI uridine monophosphokinase DAE22_RS05035 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DAE22_RS05040 ENOG4107XRG penicillin-binding protein DAE22_RS05055 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) DAE22_RS05070 ENOG4105C28 cystathionine DAE22_RS05085 ENOG4108JB9 formate dehydrogenase DAE22_RS05090 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DAE22_RS05095 ENOG4105TMB Formate nitrite transporter DAE22_RS05115 ENOG41082JN Transcriptional regulator DAE22_RS05120 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DAE22_RS05125 ENOG4105WDR DAE22_RS05130 ENOG4105EXC Acyl-transferase DAE22_RS05135 ENOG4108P49 AntiSigma factor DAE22_RS05140 ENOG4105JVQ RNA Polymerase DAE22_RS05145 ENOG4108NGU Transcriptional regulator DAE22_RS05150 ENOG4105N14 lysine exporter protein LysE YggA DAE22_RS05155 ENOG4105C85 amino acid DAE22_RS05165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DAE22_RS05170 ENOG4105YHU PTS system DAE22_RS05175 ENOG4108IQ3 PTS system DAE22_RS05180 ENOG4105ETZ PTS System DAE22_RS05185 ENOG4105F3R pts system mannose fructose sorbose family iid DAE22_RS05195 ENOG4108HKT sucrose-6-phosphate hydrolase DAE22_RS05200 ENOG4108Z0Z intracellular protease Pfpi family DAE22_RS05205 ENOG4105DQ4 alcohol dehydrogenase DAE22_RS05210 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DAE22_RS05215 ENOG4105VUF Transcriptional regulator DAE22_RS05220 ENOG4105VUF Transcriptional regulator DAE22_RS05225 ENOG4105CF7 AraC family transcriptional regulator DAE22_RS05230 ENOG4105CPC Aldo Keto reductase DAE22_RS05235 ENOG4105KRI phosphocarrier protein (HPr DAE22_RS05250 ENOG4105E2A Dehydrogenase DAE22_RS05255 ENOG4105PGS Spore coat protein DAE22_RS05265 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein DAE22_RS05270 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein DAE22_RS05275 ENOG4108UW5 maltose o-acetyltransferase DAE22_RS05285 ENOG4108VQT Alpha beta hydrolase fold protein DAE22_RS05290 ENOG4105X5K response regulator receiver protein DAE22_RS05295 ENOG41083Q9 chitosanase DAE22_RS05300 ENOG4105CPC Aldo Keto reductase DAE22_RS05305 ENOG410904A RNA polymerase DAE22_RS05310 ENOG4108MEK Metal-binding protein YodA DAE22_RS05320 ENOG4105C22 threonyL-tRNA synthetase DAE22_RS05325 ENOG4108JQ7 (ABC) transporter DAE22_RS05335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DAE22_RS05340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DAE22_RS05345 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein DAE22_RS05355 ENOG41064BW Protein of unknown function (DUF2568) DAE22_RS05365 ENOG4107U9B transcriptional regulator DAE22_RS05370 ENOG4105DXI Major Facilitator superfamily DAE22_RS05385 ENOG4105DRR Transcriptional regulator, GntR family DAE22_RS05395 ENOG4108MCI Transcriptional regulator, ARAC family DAE22_RS05400 ENOG4108UZ3 Transporter DAE22_RS05405 ENOG4105D3P Mannan endo-1,4-beta-mannosidase DAE22_RS05410 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family DAE22_RS05435 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DAE22_RS05475 ENOG41067XF inhibitor DAE22_RS05520 ENOG4108DBC nitroreductase DAE22_RS05525 ENOG4105KVH Transcriptional regulator DAE22_RS05535 ENOG4108IND Tetr family transcriptional regulator DAE22_RS05540 ENOG4105UBK short-chain dehydrogenase reductase DAE22_RS05545 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DAE22_RS05560 ENOG4105XTG Pfam:DUF156 DAE22_RS05565 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DAE22_RS05575 ENOG4105VFE sira family DAE22_RS05585 ENOG4107TPS domain protein DAE22_RS05590 ENOG4105VFE sira family DAE22_RS05595 ENOG41087NI Sulfite exporter TauE/SafE DAE22_RS05600 ENOG4105DEN Luciferase family DAE22_RS05615 ENOG4108W2Y isochorismatase DAE22_RS05620 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein DAE22_RS05625 ENOG4108HH4 Major Facilitator Superfamily DAE22_RS05645 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DAE22_RS05650 ENOG4105WFK nuclease DAE22_RS05665 ENOG41080BT SNARE associated Golgi DAE22_RS05670 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DAE22_RS05685 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DAE22_RS05690 ENOG4105CQW ribosome biogenesis GTPase YqeH DAE22_RS05695 ENOG4105E2X shikimate dehydrogenase DAE22_RS05700 ENOG410812S Rna-binding protein DAE22_RS05705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DAE22_RS05710 ENOG4108WF2 Metal Dependent Phosphohydrolase DAE22_RS05720 ENOG4108D32 Methyltransferase DAE22_RS05730 ENOG4105KQC Competence protein DAE22_RS05735 ENOG4108UK2 deaminase DAE22_RS05740 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DAE22_RS05755 ENOG4105TQK DNA polymerase iii, delta' subunit DAE22_RS05760 ENOG41082YS Binds directly to 16S ribosomal RNA DAE22_RS05765 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) DAE22_RS05770 ENOG4108ZRV stage ii sporulation protein p DAE22_RS05780 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DAE22_RS05785 ENOG4105CSA Coproporphyrinogen iii oxidase DAE22_RS05790 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DAE22_RS05795 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DAE22_RS05800 ENOG4105CFG Acts as a chaperone (By similarity) DAE22_RS05805 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DAE22_RS05810 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DAE22_RS05815 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DAE22_RS05820 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DAE22_RS05835 ENOG4105KTH gatB Yqey DAE22_RS05840 ENOG4105F7J membrane-bound serine protease DAE22_RS05845 ENOG4105DI5 UPF0365 protein DAE22_RS05855 ENOG41068P3 sporulation protein YqfC DAE22_RS05860 ENOG4105EI1 sporulation protein yqfd DAE22_RS05865 ENOG4105C9A Phoh family DAE22_RS05870 ENOG4105CTJ Metal Dependent Phosphohydrolase DAE22_RS05875 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DAE22_RS05880 ENOG4107YR5 Diacylglycerol kinase DAE22_RS05885 ENOG4105KG3 cytidine deaminase DAE22_RS05890 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DAE22_RS05900 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) DAE22_RS05905 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit DAE22_RS05910 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DAE22_RS05920 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DAE22_RS05925 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 DAE22_RS05930 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DAE22_RS05935 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DAE22_RS05950 ENOG4105EGD dinuclear metal center protein, YbgI family DAE22_RS05955 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DAE22_RS05970 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DAE22_RS05975 ENOG41069ZM Protein of unknown function (DUF2624) DAE22_RS05980 ENOG4108JYZ YitT family DAE22_RS05985 ENOG4105N80 Ferric uptake regulator, Fur family DAE22_RS05990 ENOG4108U5J '-nucleotidase DAE22_RS05995 ENOG41063Y9 DAE22_RS06000 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DAE22_RS06015 ENOG4105SXS Protein of unknown function (DUF456) DAE22_RS06020 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DAE22_RS06030 ENOG4107RF6 penicillin-binding protein DAE22_RS06035 ENOG4105CVA phosphate DAE22_RS06040 ENOG4105C8U phosphate abc transporter DAE22_RS06045 ENOG4105E2Z phosphate ABC transporter (Permease DAE22_RS06050 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DAE22_RS06055 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DAE22_RS06060 ENOG41068DG YceG-like family DAE22_RS06085 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DAE22_RS06095 ENOG4107ZXI Rhomboid family DAE22_RS06110 ENOG4105E0M Sulfatase DAE22_RS06135 ENOG4105C5X domain protein DAE22_RS06160 ENOG4105C37 (CBS) domain DAE22_RS06170 ENOG41080XP Cbs domain DAE22_RS06230 ENOG4105VFR signal peptidase DAE22_RS06240 ENOG4108IMY Transcriptional regulator DAE22_RS06255 ENOG4105C0D helicase DAE22_RS06260 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DAE22_RS06265 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DAE22_RS06270 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DAE22_RS06275 ENOG4105WZW rhodanese family DAE22_RS06280 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DAE22_RS06285 ENOG4105KST dependent repressor DAE22_RS06300 ENOG4105CBJ Metal-dependent enzyme DAE22_RS06310 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DAE22_RS06315 ENOG4105DC7 peptidase M24 DAE22_RS06320 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DAE22_RS06330 ENOG4105CD2 stage iii sporulation protein aa DAE22_RS06335 ENOG4105KR5 Stage iii sporulation protein DAE22_RS06340 ENOG4108CQH stage III sporulation protein AC DAE22_RS06345 ENOG4105KQ4 Stage iii sporulation protein ad DAE22_RS06355 ENOG410644B Stage III sporulation protein af DAE22_RS06375 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DAE22_RS06380 ENOG4108ZSR alkaline shock protein DAE22_RS06385 ENOG4105M7K Involved in the transcription termination process (By similarity) DAE22_RS06390 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DAE22_RS06395 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DAE22_RS06400 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DAE22_RS06405 ENOG4105CTB Polyprenyl synthetase DAE22_RS06415 ENOG4105DX0 Hemolysin A DAE22_RS06420 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DAE22_RS06425 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DAE22_RS06430 ENOG4105S1Z Stage IV sporulation protein B DAE22_RS06435 ENOG4107QQR Sporulation DAE22_RS06445 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DAE22_RS06460 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DAE22_RS06465 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DAE22_RS06475 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DAE22_RS06480 ENOG4105C1G acyl-Coa dehydrogenase DAE22_RS06490 ENOG4105DXD 2-methylcitrate dehydratase DAE22_RS06495 ENOG4105CR4 methylisocitrate lyase DAE22_RS06500 ENOG4106CCJ Protein of unknown function (DUF2627) DAE22_RS06505 ENOG4108JUB Transcriptional regulator DAE22_RS06515 ENOG4107RDP Dehydrogenase DAE22_RS06520 ENOG4105CKM Branched-chain carboxylic acid kinase DAE22_RS06535 ENOG4105CPP Dehydrogenase, E1 component DAE22_RS06540 ENOG4105C7S Dehydrogenase DAE22_RS06555 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DAE22_RS06560 ENOG4108Y6J UPF0403 protein DAE22_RS06565 ENOG4108HW3 (ABC) transporter DAE22_RS06570 ENOG4105E5Q amino acid AbC transporter DAE22_RS06575 ENOG4105CDA abc transporter atp-binding protein DAE22_RS06580 ENOG4108QEG Membrane DAE22_RS06585 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DAE22_RS06595 ENOG4108ZVT methylmalonyl-coA epimerase DAE22_RS06600 ENOG4108HNZ carboxyl transferase DAE22_RS06605 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DAE22_RS06610 ENOG4108NA0 Uncharacterized conserved protein (COG2071) DAE22_RS06615 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) DAE22_RS06625 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DAE22_RS06630 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DAE22_RS06635 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DAE22_RS06640 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DAE22_RS06645 ENOG410861F 50S ribosomal protein L33 DAE22_RS06655 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DAE22_RS06665 ENOG4105II7 pyrroline-5-carboxylate reductase DAE22_RS06670 ENOG41069FQ Metallo-beta-lactamase superfamily DAE22_RS06675 ENOG4108IXY short-chain dehydrogenase reductase DAE22_RS06710 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DAE22_RS06720 ENOG4108XET gCN5-related N-acetyltransferase DAE22_RS06725 ENOG4105KAC Antibiotic biosynthesis monooxygenase DAE22_RS06730 ENOG4105RHY Pfam:UPF0157 DAE22_RS06735 ENOG4106HZJ DAE22_RS06755 ENOG4105CPC Aldo Keto reductase DAE22_RS06765 ENOG4108YZ4 nudix hydrolase DAE22_RS06775 ENOG4108IMY Transcriptional regulator DAE22_RS06780 ENOG4105HDK L-asparaginase DAE22_RS06785 ENOG4108IJ0 Aspartate ammonia-lyase DAE22_RS06790 ENOG4105DFD Na H antiporter DAE22_RS06805 ENOG4105MZ9 stage II sporulation protein m DAE22_RS06810 ENOG4105I3K Ferric uptake regulator, Fur family DAE22_RS06820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DAE22_RS06825 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DAE22_RS06830 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) DAE22_RS06835 ENOG4105DZ1 carboxypeptidase DAE22_RS06840 ENOG41082AN stage II sporulation protein DAE22_RS06845 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DAE22_RS06850 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DAE22_RS06865 ENOG41090VF Stage v sporulation protein ac DAE22_RS06870 ENOG4105CZ3 stage V sporulation protein ad DAE22_RS06880 ENOG4105G6R Stage v sporulation protein ae DAE22_RS06890 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DAE22_RS06895 ENOG4105PTM secreted protein DAE22_RS06900 ENOG4107ZE5 PPIases accelerate the folding of proteins DAE22_RS06915 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) DAE22_RS06920 ENOG4105C3F Signal peptidase i DAE22_RS06935 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DAE22_RS06940 ENOG4108R6K riboflavin synthase, subunit alpha DAE22_RS06945 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DAE22_RS06950 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DAE22_RS06965 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DAE22_RS06970 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DAE22_RS06980 ENOG4105DZ1 carboxypeptidase DAE22_RS06985 ENOG4108JIC nucleoside recognition domain protein DAE22_RS06995 ENOG4105FE9 pseudouridine synthase DAE22_RS07005 ENOG4107TWT Cytochrome c biogenesis protein DAE22_RS07010 ENOG4105CRE cytochrome C DAE22_RS07015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DAE22_RS07020 ENOG4105BZU Histidine kinase DAE22_RS07035 ENOG4105FF2 Type I DHQase DAE22_RS07040 ENOG4108JQ1 Dehydrogenase DAE22_RS07045 ENOG4108SAX Membrane DAE22_RS07055 ENOG4105T7X DAE22_RS07060 ENOG4105C9U ATP-dependent DNA helicase RecQ DAE22_RS07065 ENOG4105I7S Abortive infection protein DAE22_RS07080 ENOG4107RGJ metallophosphoesterase DAE22_RS07095 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DAE22_RS07100 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) DAE22_RS07110 ENOG4105MSI germination protein ypeb DAE22_RS07125 ENOG4105CAT Cytidine monophosphate kinase DAE22_RS07130 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DAE22_RS07135 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DAE22_RS07150 ENOG4105S2F DAE22_RS07155 ENOG41065D1 DAE22_RS07160 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DAE22_RS07165 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DAE22_RS07180 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DAE22_RS07185 ENOG4105K70 DNA-binding protein DAE22_RS07190 ENOG4105EUJ GTP cyclohydrolase i DAE22_RS07200 ENOG4105XXQ heptaprenyl diphosphate synthase component I DAE22_RS07205 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DAE22_RS07210 ENOG4105EAH synthase DAE22_RS07215 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DAE22_RS07220 ENOG4105BZU Histidine kinase DAE22_RS07225 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DAE22_RS07230 ENOG4105D49 3-dehydroquinate synthase DAE22_RS07235 ENOG4105KHN chorismate mutase DAE22_RS07240 ENOG4105CRQ synthase (Component I) DAE22_RS07245 ENOG4108I0Q anthranilate phosphoribosyltransferase DAE22_RS07255 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase DAE22_RS07260 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DAE22_RS07270 ENOG4105CIH Imidazole acetol-phosphate transaminase DAE22_RS07280 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DAE22_RS07285 ENOG41068YB TPR repeat-containing protein DAE22_RS07305 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DAE22_RS07325 ENOG4108JYZ YitT family DAE22_RS07330 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DAE22_RS07335 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DAE22_RS07340 ENOG4108Z5K methylglyoxal synthase DAE22_RS07345 ENOG4105FJR Lmbe family DAE22_RS07350 ENOG4105CPK Glycosyl transferase (Group 1 DAE22_RS07355 ENOG4105DJ0 Poly(A) Polymerase DAE22_RS07360 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase DAE22_RS07365 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DAE22_RS07370 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DAE22_RS07375 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) DAE22_RS07380 ENOG4105DVT helicase DAE22_RS07385 ENOG4105YAC DAE22_RS07395 ENOG4105CHM Aminotransferase DAE22_RS07400 ENOG4105C5S asparaginyl-tRNA synthetase DAE22_RS07410 ENOG4105CSM endonuclease III DAE22_RS07420 ENOG4105BZ4 penicillin-binding protein DAE22_RS07470 ENOG4108I5C dEAD DEAH box helicase DAE22_RS07475 ENOG4107X2U Inherit from COG: Exonuclease-like protein DAE22_RS07490 ENOG4108UKS UPF0398 protein DAE22_RS07505 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DAE22_RS07520 ENOG4105DVT helicase DAE22_RS07525 ENOG4105CHR reductase DAE22_RS07535 ENOG4108M60 Transcriptional regulator DAE22_RS07540 ENOG4105D7K pfkb domain protein DAE22_RS07545 ENOG4108UHU Aldolase DAE22_RS07550 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) DAE22_RS07555 ENOG4105CTD carboxy-peptidase DAE22_RS07560 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DAE22_RS07565 ENOG4105C2W permease DAE22_RS07570 ENOG41065KQ synthase DAE22_RS07585 ENOG410890F Dynamin family DAE22_RS07610 ENOG41081VK Ribonuclease DAE22_RS07655 ENOG4105CVG Homoserine O-transsuccinylase DAE22_RS07660 ENOG4108V06 Glutathione peroxidase DAE22_RS07675 ENOG4105C01 Dihydroxy-acid dehydratase DAE22_RS07680 ENOG4108Y6J UPF0403 protein DAE22_RS07685 ENOG4107YX5 Pfam:DUF548 DAE22_RS07705 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DAE22_RS07715 ENOG4108UT2 hemolysin iii DAE22_RS07725 ENOG4105C7B Threonine dehydratase DAE22_RS07735 ENOG4108KF3 Electron transport protein SCO1 SenC DAE22_RS07740 ENOG41090WU lipolytic protein G-D-S-L family DAE22_RS07745 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) DAE22_RS07765 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DAE22_RS07770 ENOG4105E0X reductase DAE22_RS07775 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DAE22_RS07780 ENOG4107T32 3-phytase (EC 3.1.3.8) DAE22_RS07815 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DAE22_RS07830 ENOG4107S4Y M20 DapE family protein YgeY DAE22_RS07835 ENOG4108TSC N-acetyltransferase DAE22_RS07840 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DAE22_RS07870 ENOG410841Q phosphoesterase PA-phosphatase related protein DAE22_RS07875 ENOG4106Z5R DAE22_RS07885 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DAE22_RS07890 ENOG4108VXD carboxy-peptidase DAE22_RS07910 ENOG4105E1V na solute symporter DAE22_RS07925 ENOG4105FBA Phospholipase Carboxylesterase DAE22_RS07945 ENOG41090U3 tautomerase DAE22_RS07950 ENOG4105C6Z Gluconate DAE22_RS07965 ENOG4105FR1 rard protein DAE22_RS07985 ENOG4106SCS STAS domain DAE22_RS07990 ENOG4107QMU Mate efflux family protein DAE22_RS08000 ENOG41087PP glycosyltransferase MGT family DAE22_RS08005 ENOG4105K4H Nlp p60 protein DAE22_RS08015 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DAE22_RS08020 ENOG4107T89 von Willebrand factor, type A DAE22_RS08030 ENOG4105C7S Dehydrogenase DAE22_RS08035 ENOG4105C09 Bile acid DAE22_RS08040 ENOG4105C8J )-transporter DAE22_RS08045 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DAE22_RS08050 ENOG4105EWU Squalene--hopene cyclase DAE22_RS08055 ENOG4105C26 Dehydrogenase DAE22_RS08070 ENOG4105SCY DNAK suppressor DAE22_RS08075 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DAE22_RS08085 ENOG4105C9U ATP-dependent DNA helicase RecQ DAE22_RS08090 ENOG41069ER domain protein DAE22_RS08095 ENOG4108S01 response regulator DAE22_RS08100 ENOG4108ZGX Histidine kinase DAE22_RS08105 ENOG4105ECK Fatty Acid Desaturase DAE22_RS08125 ENOG4108SJC Membrane DAE22_RS08135 ENOG4105KTU Transcriptional regulator, arsr family DAE22_RS08145 ENOG4105D29 Helix-turn-helix type 11 domain protein DAE22_RS08155 ENOG4108W8B Beta-lactamase domain protein DAE22_RS08165 ENOG4108HJF gCN5-related N-acetyltransferase DAE22_RS08170 ENOG4105FTV AraC Family Transcriptional Regulator DAE22_RS08175 ENOG4108Z7R Chaperone CsaA DAE22_RS08190 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DAE22_RS08210 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin DAE22_RS08275 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DAE22_RS08300 ENOG4107R0E Glycosyl transferase, family 2 DAE22_RS08345 ENOG4107NTZ DAE22_RS08415 ENOG4107T94 Endo-14-beta-xylanase DAE22_RS08440 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DAE22_RS08450 ENOG4108M1A Chitin-binding protein DAE22_RS08460 ENOG4108J4B Beta-lactamase DAE22_RS08470 ENOG4108V4B ThiJ pfpI DAE22_RS08485 ENOG4108Q5Y Membrane DAE22_RS08495 ENOG4105NX3 Membrane DAE22_RS08510 ENOG41073R8 VanW family DAE22_RS08535 ENOG410780I phosphoprotein phosphatase activity DAE22_RS08545 ENOG4105F0F Oxalate decarboxylase DAE22_RS08555 ENOG4108RAV Conserved protein DAE22_RS08575 ENOG4108NR7 pectate lyase DAE22_RS08580 ENOG4105XPP Protein of unknown function (DUF1275) DAE22_RS08585 ENOG4108YQE rare lipoprotein a DAE22_RS08595 ENOG4105EC8 Methyl-accepting chemotaxis DAE22_RS08610 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DAE22_RS08625 ENOG4108J2R molybdopterin oxidoreductase DAE22_RS08630 ENOG4108M3J Dehydrogenase DAE22_RS08635 ENOG4107U6E carbohydrate kinase FGGY DAE22_RS08640 ENOG4105IE8 Alpha-ketoglutarate permease DAE22_RS08645 ENOG41068WN DAE22_RS08650 ENOG4108UB7 DAE22_RS08675 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DAE22_RS08680 ENOG4105C5Q Transcriptional regulator DAE22_RS08685 ENOG4105CBC glutamate synthase DAE22_RS08690 ENOG4105BZ8 glutamate synthase DAE22_RS08695 ENOG4105CB2 alcohol dehydrogenase DAE22_RS08700 ENOG4105SKE transcriptional Regulator LysR family DAE22_RS08705 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DAE22_RS08730 ENOG4107QJQ Mate efflux family protein DAE22_RS08735 ENOG4108N2V aldose 1-epimerase DAE22_RS08740 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family DAE22_RS08745 ENOG4105C0W non-ribosomal peptide synthetase DAE22_RS08755 ENOG4105C0W non-ribosomal peptide synthetase DAE22_RS08760 ENOG4105CEY Amp-dependent synthetase and ligase DAE22_RS08770 ENOG4106U2H Protein of unknown function (DUF1360) DAE22_RS08775 ENOG4105F32 YngK protein DAE22_RS08785 ENOG41062JF Transcriptional regulator DAE22_RS08795 ENOG4105C1G acyl-Coa dehydrogenase DAE22_RS08800 ENOG4105CEY Amp-dependent synthetase and ligase DAE22_RS08805 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DAE22_RS08810 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DAE22_RS08815 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DAE22_RS08820 ENOG4105E39 Enoyl-CoA hydratase DAE22_RS08825 ENOG4107QX3 carboxylase DAE22_RS08835 ENOG4107T5V SNARE associated Golgi DAE22_RS08840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DAE22_RS08870 ENOG4108MYR Secreted protein DAE22_RS08900 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DAE22_RS08905 ENOG4105K4P CoA-binding domain protein DAE22_RS08910 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DAE22_RS08915 ENOG4105W8X HesB YadR YfhF-family protein DAE22_RS08920 ENOG4105MI2 DAE22_RS08930 ENOG41067CD Small, acid-soluble spore protein Tlp DAE22_RS08945 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DAE22_RS08950 ENOG4108I0Z Aconitate hydratase DAE22_RS08960 ENOG4107DZX Small, acid-soluble spore protein P DAE22_RS08985 ENOG4107QIV Cytochrome c biogenesis protein DAE22_RS09005 ENOG4105CV1 Transketolase (EC 2.2.1.1) DAE22_RS09010 ENOG4105VPS UPF0291 protein DAE22_RS09015 ENOG4108SVB resolvase DAE22_RS09025 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DAE22_RS09035 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DAE22_RS09045 ENOG4105K7W phage-related replication protein DAE22_RS09055 ENOG4105FVX DAE22_RS09070 ENOG4108NHD germination protein DAE22_RS09075 ENOG4108Q8B Spore germination protein DAE22_RS09085 ENOG4105CAH Chromate DAE22_RS09155 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DAE22_RS09165 ENOG4105C54 Major Facilitator superfamily DAE22_RS09170 ENOG4107Y9E nuclease DAE22_RS09180 ENOG4105CMG Carbohydrate kinase DAE22_RS09195 ENOG4105DSG hydrolase family 43 DAE22_RS09200 ENOG4105CT4 transporter DAE22_RS09235 ENOG410907G DAE22_RS09270 ENOG4105KVH Transcriptional regulator DAE22_RS09275 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DAE22_RS09305 ENOG4105C5F glutamine synthetase DAE22_RS09310 ENOG4105KV4 Transcriptional regulator DAE22_RS09315 ENOG4105CXI aluminum resistance protein DAE22_RS09320 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DAE22_RS09325 ENOG4106F1P AAA ATPase, central domain protein DAE22_RS09330 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DAE22_RS09335 ENOG4105U6W MutT NUDIX family protein DAE22_RS09340 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DAE22_RS09345 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DAE22_RS09350 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DAE22_RS09365 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DAE22_RS09370 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DAE22_RS09395 ENOG4108X3M OsmC Ohr family protein DAE22_RS09400 ENOG4105K7W phage-related replication protein DAE22_RS09405 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DAE22_RS09420 ENOG4105W1N transcriptional regulator DAE22_RS09425 ENOG4105IIP Membrane DAE22_RS09455 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DAE22_RS09460 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DAE22_RS09465 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DAE22_RS09480 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DAE22_RS09485 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DAE22_RS09495 ENOG4105MCT stage V sporulation protein S DAE22_RS09500 ENOG4105D48 metallophosphoesterase DAE22_RS09505 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) DAE22_RS09510 ENOG4108A04 Beta-lactamase DAE22_RS09520 ENOG4105CEV competence damage-inducible protein DAE22_RS09525 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DAE22_RS09540 ENOG4105XZV Protein of unknown function (DUF3243) DAE22_RS09545 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DAE22_RS09565 ENOG4105FDP GntR family transcriptional regulator DAE22_RS09570 ENOG4105CNU cell division protein FtsK DAE22_RS09580 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DAE22_RS09590 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DAE22_RS09600 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DAE22_RS09605 ENOG4108S0H Dipicolinic acid synthetase, b subunit DAE22_RS09610 ENOG4105E35 Dipicolinate synthase subunit A DAE22_RS09620 ENOG4105C1V Peptidase, M16 DAE22_RS09630 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DAE22_RS09635 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DAE22_RS09640 ENOG4105DTN riboflavin biosynthesis protein ribF DAE22_RS09645 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DAE22_RS09650 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DAE22_RS09655 ENOG4105W7A Protein of unknown function (DUF503) DAE22_RS09660 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DAE22_RS09665 ENOG4105VHM ribosomal protein DAE22_RS09670 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DAE22_RS09675 ENOG4105CHV Transcription elongation factor NusA DAE22_RS09680 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DAE22_RS09685 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DAE22_RS09690 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DAE22_RS09695 ENOG4105DZP Membrane-associated zinc metalloprotease DAE22_RS09705 ENOG4105KNE Phosphatidate cytidylyltransferase DAE22_RS09710 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DAE22_RS09715 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DAE22_RS09725 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DAE22_RS09730 ENOG4105CE9 30S ribosomal protein S2 DAE22_RS09740 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DAE22_RS09755 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis DAE22_RS09760 ENOG4105CBS Chea signal transduction histidine kinase DAE22_RS09765 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DAE22_RS09775 ENOG4105FZW flagellar biosynthesis regulator FlhF DAE22_RS09780 ENOG4105D7B Flagellar biosynthesis protein flha DAE22_RS09785 ENOG4105D00 flagellar biosynthetic protein flhB DAE22_RS09795 ENOG4105VS8 Flagellar biosynthetic protein fliq DAE22_RS09800 ENOG4105CN7 Flagellar biosynthetic protein FliP DAE22_RS09810 ENOG4107YTP response regulator receiver protein DAE22_RS09815 ENOG4105DD5 Flagellar motor switch protein DAE22_RS09820 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DAE22_RS09830 ENOG41068WV flagellar FlbD family protein DAE22_RS09835 ENOG4108JQA flagellar DAE22_RS09840 ENOG410822I Flagellar hook capping protein DAE22_RS09845 ENOG410696Y Flagellar hook-length control protein DAE22_RS09855 ENOG4106YF4 Flagellar biosynthesis chaperone DAE22_RS09870 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DAE22_RS09875 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DAE22_RS09880 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DAE22_RS09885 ENOG4108ZC9 flagellar basal-body rod protein flgc DAE22_RS09890 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DAE22_RS09900 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DAE22_RS09905 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DAE22_RS09910 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DAE22_RS09915 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) DAE22_RS09920 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DAE22_RS09925 ENOG4105C79 DNA protecting protein DprA DAE22_RS09930 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DAE22_RS09935 ENOG4105CMV Succinyl-CoA synthetase subunit beta DAE22_RS09940 ENOG4105VM1 flagellar DAE22_RS09950 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DAE22_RS09955 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DAE22_RS09960 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DAE22_RS09965 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DAE22_RS09970 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DAE22_RS09980 ENOG4108BW8 UPF0109 protein DAE22_RS09985 ENOG4105K5M 30s ribosomal protein S16 DAE22_RS09995 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) DAE22_RS10005 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DAE22_RS10010 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DAE22_RS10015 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DAE22_RS10025 ENOG4105CHR reductase DAE22_RS10030 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DAE22_RS10040 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) DAE22_RS10045 ENOG4105CB5 ATP-dependent DNA helicase recG DAE22_RS10050 ENOG4105EJQ L-serine dehydratase DAE22_RS10060 ENOG4105DP4 dak2 domain fusion protein ylov DAE22_RS10065 ENOG4108ZAA Alkaline-shock protein DAE22_RS10070 ENOG4105VB9 50S ribosomal protein l28 DAE22_RS10080 ENOG4105FJ0 thiamine DAE22_RS10085 ENOG4105DJV ribulose-phosphate 3-epimerase DAE22_RS10090 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DAE22_RS10095 ENOG4105D9P serine threonine protein kinase DAE22_RS10100 ENOG4108ZF3 Phosphatase DAE22_RS10105 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DAE22_RS10110 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DAE22_RS10115 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DAE22_RS10120 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DAE22_RS10125 ENOG4105C25 Primosomal protein n' DAE22_RS10130 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DAE22_RS10140 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DAE22_RS10145 ENOG4105KC4 UPF0296 protein DAE22_RS10150 ENOG4105DSJ YicC domain protein DAE22_RS10165 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DAE22_RS10170 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DAE22_RS10175 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DAE22_RS10180 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DAE22_RS10185 ENOG4107S4M Sulfate adenylate transferase DAE22_RS10195 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DAE22_RS10200 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DAE22_RS10205 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DAE22_RS10210 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DAE22_RS10215 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DAE22_RS10220 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DAE22_RS10225 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DAE22_RS10235 ENOG4105CXT aspartate transcarbamylase DAE22_RS10245 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DAE22_RS10250 ENOG4105C34 Pseudouridine synthase DAE22_RS10255 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DAE22_RS10265 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DAE22_RS10275 ENOG4105DBK s4 domain protein DAE22_RS10280 ENOG41067XK integral membrane protein DAE22_RS10285 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DAE22_RS10290 ENOG4105DFA alanine racemase domain protein DAE22_RS10295 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DAE22_RS10300 ENOG4105WR5 sporulation protein, YlmC YmxH family DAE22_RS10310 ENOG4105DKW ABC transporter DAE22_RS10320 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DAE22_RS10325 ENOG4105FFI sigma-e processing peptidase spoiiga DAE22_RS10335 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DAE22_RS10340 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DAE22_RS10345 ENOG4105K67 small basic protein DAE22_RS10355 ENOG4108R2U division initiation protein DAE22_RS10360 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DAE22_RS10365 ENOG4105D4A Cell wall formation (By similarity) DAE22_RS10370 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DAE22_RS10375 ENOG4105CNI cell division protein FtsW DAE22_RS10380 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DAE22_RS10385 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DAE22_RS10390 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DAE22_RS10395 ENOG4105CJN penicillin-binding protein DAE22_RS10400 ENOG4105CJN penicillin-binding protein DAE22_RS10410 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DAE22_RS10415 ENOG4108V6E Cell division protein mraZ DAE22_RS10445 ENOG4105KNH Nucleic acid-binding protein DAE22_RS10455 ENOG4105CDE UPF0348 protein DAE22_RS10460 ENOG41063PX domain protein DAE22_RS10465 ENOG4105D78 K07001 NTE family protein DAE22_RS10470 ENOG4105H20 Sporulation integral membrane protein YlbJ DAE22_RS10475 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DAE22_RS10480 ENOG4106H78 methyltransferase DAE22_RS10485 ENOG4105WUC UPF0298 protein DAE22_RS10505 ENOG4106UY4 Inherit from COG: Scp-like extracellular DAE22_RS10510 ENOG41080XQ Signal transduction protein with cbs domains DAE22_RS10525 ENOG41064X9 cytochrome C oxidase subunit IV DAE22_RS10530 ENOG4105CCU oxidase (Subunit III) DAE22_RS10535 ENOG4105BZ9 Cytochrome C oxidase, subunit I DAE22_RS10545 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DAE22_RS10555 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DAE22_RS10560 ENOG4105CNI cell division protein FtsW DAE22_RS10565 ENOG4105ZPI UPF0358 protein DAE22_RS10570 ENOG4105CSV Glutaminase DAE22_RS10580 ENOG4108IAB Phoh family DAE22_RS10595 ENOG4105QA2 DAE22_RS10600 ENOG4105CI3 gtp-binding protein typa DAE22_RS10640 ENOG4108Z40 Transcriptional regulator DAE22_RS10660 ENOG4105ECY inositol monophosphatase DAE22_RS10675 ENOG4105WBI UPF0223 protein DAE22_RS10680 ENOG4105CXN decarboxylase DAE22_RS10700 ENOG4107QN2 dihydrolipoyl dehydrogenase DAE22_RS10705 ENOG4105C7S Dehydrogenase DAE22_RS10710 ENOG4105CPP Dehydrogenase, E1 component DAE22_RS10730 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DAE22_RS10735 ENOG4108X4Q Hydrolase DAE22_RS10745 ENOG4105CN5 Metallo-Beta-Lactamase DAE22_RS10755 ENOG4107ZYR domain protein DAE22_RS10765 ENOG4105BZU Histidine kinase DAE22_RS10790 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DAE22_RS10795 ENOG4105C5H ABC transporter DAE22_RS10805 ENOG4105C3F Signal peptidase i DAE22_RS10810 ENOG4105DM4 PTS System DAE22_RS10815 ENOG4105DE4 1-phosphofructokinase DAE22_RS10820 ENOG4105E98 transcriptional regulator DeoR family DAE22_RS10825 ENOG4107RBB ABC transporter, permease DAE22_RS10835 ENOG4107X8C Efflux transporter RND family MFP subunit DAE22_RS10845 ENOG4105BZ1 (ABC) transporter DAE22_RS10850 ENOG4105BZ1 (ABC) transporter DAE22_RS10855 ENOG41067WU Molybdopterin converting factor (Subunit 1) DAE22_RS10860 ENOG4108ZAF Molybdopterin DAE22_RS10865 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DAE22_RS10870 ENOG4105CVM Molybdenum cofactor synthesis domain protein DAE22_RS10875 ENOG4105D06 uba thif-type nad fad binding protein DAE22_RS10880 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DAE22_RS10895 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DAE22_RS10900 ENOG4105D3R alkyl hydroperoxide reductase DAE22_RS10905 ENOG4105D8X mechanosensitive ion channel DAE22_RS10915 ENOG4105CH2 amidohydrolase DAE22_RS10925 ENOG4105NQC Flavodoxin DAE22_RS10955 ENOG4108XRC Protein of unknown function (DUF458) DAE22_RS10960 ENOG4107IN1 Protein of unknown function (DUF1797) DAE22_RS10965 ENOG4105EPM Diguanylate phosphodiesterase DAE22_RS10970 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DAE22_RS10980 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein DAE22_RS10990 ENOG4105UIN DAE22_RS10995 ENOG4107R88 Chemotaxis protein (CheV) DAE22_RS11005 ENOG4105CHM Aminotransferase DAE22_RS11010 ENOG4105BZU Histidine kinase DAE22_RS11020 ENOG4105K4I Scp-like extracellular DAE22_RS11030 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DAE22_RS11035 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DAE22_RS11045 ENOG4105F6S Spore photoproduct lyase DAE22_RS11055 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DAE22_RS11060 ENOG4105KRI phosphocarrier protein (HPr DAE22_RS11070 ENOG4105CID antiterminator DAE22_RS11080 ENOG4105DC7 peptidase M24 DAE22_RS11090 ENOG4105C59 p-type ATPase DAE22_RS11105 ENOG4105F0V Cell wall hydrolase DAE22_RS11135 ENOG4105FEA Spore maturation protein DAE22_RS11140 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DAE22_RS11145 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DAE22_RS11150 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase DAE22_RS11155 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DAE22_RS11160 ENOG4108K88 Membrane DAE22_RS11170 ENOG4105E14 MotA TolQ exbB proton channel DAE22_RS11175 ENOG4105ER2 Ompa motb domain protein DAE22_RS11180 ENOG41090MY MarR family Transcriptional regulator DAE22_RS11185 ENOG4105BZU Histidine kinase DAE22_RS11205 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DAE22_RS11210 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DAE22_RS11215 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) DAE22_RS11220 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit DAE22_RS11230 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DAE22_RS11235 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DAE22_RS11240 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DAE22_RS11250 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DAE22_RS11255 ENOG4105BZU Histidine kinase DAE22_RS11260 ENOG4108TGC Acyltransferase DAE22_RS11280 ENOG4105D0M Protease HtpX homolog DAE22_RS11290 ENOG410681C small acid-soluble spore protein DAE22_RS11300 ENOG4108WZW RNA polymerase sigma DAE22_RS11305 ENOG4107TS3 membrane protein, TerC DAE22_RS11310 ENOG4107T5V SNARE associated Golgi DAE22_RS11315 ENOG4105BZU Histidine kinase DAE22_RS11320 ENOG4105FDF Could be involved in DNA repair (By similarity) DAE22_RS11325 ENOG4105DQE DNA ligase DAE22_RS11370 ENOG4105V75 Transcriptional regulator DAE22_RS11375 ENOG4105CJW magnesium transporter DAE22_RS11385 ENOG4106849 propeptide, pepSY amd peptidase M4 DAE22_RS11395 ENOG41062D9 Histidine kinase DAE22_RS11400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DAE22_RS11405 ENOG4108X43 YKOF domain protein DAE22_RS11410 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein DAE22_RS11415 ENOG4108JJB ABC transporter DAE22_RS11420 ENOG4108W7F transporter, permease DAE22_RS11430 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DAE22_RS11435 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DAE22_RS11445 ENOG4107Y2X deaminase DAE22_RS11450 ENOG4107TVC Glycosyl transferase, family 2 DAE22_RS11455 ENOG4108ZHJ Organic hydroperoxide resistance protein DAE22_RS11460 ENOG4105K56 Transcriptional regulator DAE22_RS11475 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DAE22_RS11480 ENOG4105CIY formyltetrahydrofolate deformylase DAE22_RS11485 ENOG41080TC multidrug resistance protein DAE22_RS11495 ENOG4108428 Inherit from COG: -acetyltransferase DAE22_RS11515 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DAE22_RS11520 ENOG4108S4H thioesterase Superfamily protein DAE22_RS11525 ENOG4107TUM Amidinotransferase DAE22_RS11530 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DAE22_RS11535 ENOG4108JQ7 (ABC) transporter DAE22_RS11540 ENOG4107SN7 NLP P60 protein DAE22_RS11545 ENOG4105DTQ mandelate racemase muconate lactonizing DAE22_RS11550 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DAE22_RS11560 ENOG4105C3U ABC transporter DAE22_RS11565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DAE22_RS11570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DAE22_RS11575 ENOG4108ME1 Peptidase M55 D-aminopeptidase DAE22_RS11585 ENOG4105C0H protease DAE22_RS11590 ENOG4105CKK Glycosyl transferase, family 2 DAE22_RS11595 ENOG4105EDW glycosyl transferase, family 39 DAE22_RS11610 ENOG4107R7I amino acid DAE22_RS11615 ENOG4107GRR phosphate transport regulator DAE22_RS11620 ENOG4105CJ3 phosphate transporter DAE22_RS11640 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DAE22_RS11670 ENOG41068G1 DAE22_RS11680 ENOG410906S phage-like element pbsx protein xkdt DAE22_RS11685 ENOG41066EA baseplate J family protein DAE22_RS11690 ENOG4105MFU Protein of unknown function (DUF2634) DAE22_RS11700 ENOG4105X7F DAE22_RS11705 ENOG4108WZM domain protein DAE22_RS11710 ENOG4108FKH Transglycosylase SLT domain DAE22_RS11720 ENOG4105MTC XkdN-like protein DAE22_RS11725 ENOG4105FR7 XkdM protein, phage-like element PBSX DAE22_RS11730 ENOG4105PQS phage protein DAE22_RS11745 ENOG41060SN DAE22_RS11770 ENOG4108MDF Phage Portal Protein DAE22_RS11775 ENOG4105IG6 Phage terminase, large subunit DAE22_RS11780 ENOG4108TFU terminase (Small subunit) DAE22_RS11825 ENOG410635T phage-like element pbsx protein DAE22_RS11830 ENOG4105WEF catalase DAE22_RS11835 ENOG4105K7W phage-related replication protein DAE22_RS11840 ENOG4105KWG Pfam:DUF1696 DAE22_RS11845 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DAE22_RS11850 ENOG41068K0 YCII-related domain DAE22_RS11870 ENOG4107TSN permease DAE22_RS11875 ENOG4105CTX dehydratase DAE22_RS11880 ENOG4107QZW Altronate oxidoreductase DAE22_RS11885 ENOG4107KJX Transcriptional regulator DAE22_RS11890 ENOG4108I5G Major Facilitator superfamily DAE22_RS11895 ENOG4105DMW Dehydrogenase reductase DAE22_RS11900 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DAE22_RS11905 ENOG4105CPQ Dehydrogenase DAE22_RS11910 ENOG4105DG4 malate L-lactate dehydrogenase DAE22_RS11915 ENOG4105CT4 transporter DAE22_RS11920 ENOG4105D2H Uronic isomerase DAE22_RS11935 ENOG4105Q95 Cupin 2, conserved barrel domain protein DAE22_RS11945 ENOG4108IXI (ABC) transporter DAE22_RS11950 ENOG4105C4B ABC transporter, permease DAE22_RS11955 ENOG4105EXQ uroporphyrinogen iii synthase hem4 DAE22_RS11965 ENOG41087PP glycosyltransferase MGT family DAE22_RS11970 ENOG4106A3M Cytochrome p-450 DAE22_RS11995 ENOG4108IEG Formate dehydrogenase Alpha subunit DAE22_RS12020 ENOG4107CUJ Protein of unknown function (DUF2690) DAE22_RS12025 ENOG4108ZJ4 polysaccharide deacetylase DAE22_RS12035 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DAE22_RS12055 ENOG4108Z66 YbaK ebsC protein DAE22_RS12065 ENOG4105VMI -acetyltransferase DAE22_RS12080 ENOG4105DG6 mannose-6-phosphate isomerase DAE22_RS12085 ENOG4105DM4 PTS System DAE22_RS12100 ENOG4108PSK reductase DAE22_RS12115 ENOG4105JHY Membrane DAE22_RS12120 ENOG4105D9U N-acetyltransferase DAE22_RS12125 ENOG4105C28 cystathionine DAE22_RS12130 ENOG4105C28 cystathionine DAE22_RS12140 ENOG4108ZMI UPF0477 protein DAE22_RS12155 ENOG4105ENA helicase DAE22_RS12205 ENOG4107A88 DAE22_RS12210 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DAE22_RS12215 ENOG4105DWF phosphomethylpyrimidine kinase DAE22_RS12220 ENOG4105D06 uba thif-type nad fad binding protein DAE22_RS12225 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DAE22_RS12240 ENOG4108VEU Thiamine monophosphate synthase DAE22_RS12245 ENOG4105ETU transcriptional activator (TenA DAE22_RS12260 ENOG4105EMS pseudouridine synthase DAE22_RS12265 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DAE22_RS12280 ENOG4105MIX Adenylate cyclase DAE22_RS12285 ENOG4105E4C Lytic transglycosylase catalytic DAE22_RS12290 ENOG4108Z18 K06886 hemoglobin DAE22_RS12295 ENOG4105T58 Dithiol-disulfide isomerase DAE22_RS12305 ENOG4105DPN Oligoendopeptidase f DAE22_RS12315 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis DAE22_RS12325 ENOG4108ZCF integral membrane protein DAE22_RS12330 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DAE22_RS12345 ENOG4108JQ7 (ABC) transporter DAE22_RS12355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DAE22_RS12360 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DAE22_RS12365 ENOG4108J59 Extracellular solute-binding protein, family 5 DAE22_RS12370 ENOG4105C31 Tryptophanyl-tRNA synthetase DAE22_RS12380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DAE22_RS12395 ENOG4108JQ7 (ABC) transporter DAE22_RS12400 ENOG4105C3U ABC transporter DAE22_RS12410 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DAE22_RS12415 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DAE22_RS12430 ENOG4107RMD Basic membrane lipoprotein DAE22_RS12455 ENOG4105DBV ornithine carbamoyltransferase DAE22_RS12465 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DAE22_RS12470 ENOG4105C8Y Acetylornithine aminotransferase DAE22_RS12480 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DAE22_RS12485 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DAE22_RS12495 ENOG4105IQ5 FAD linked oxidase domain protein DAE22_RS12505 ENOG4105VG1 fes assembly suf system protein DAE22_RS12510 ENOG4108MXZ Esterase DAE22_RS12515 ENOG4108KP7 hydrolase DAE22_RS12525 ENOG41073B9 DAE22_RS12535 ENOG4107AYK membrAne DAE22_RS12540 ENOG4105EPR degv family DAE22_RS12545 ENOG4105D4Y metalloprotease DAE22_RS12550 ENOG410751J DAE22_RS12560 ENOG4105K7K Transcriptional regulator DAE22_RS12580 ENOG4105QNR S1 RNA binding domain protein DAE22_RS12585 ENOG4108VPT UPF0234 protein DAE22_RS12595 ENOG4105MA6 gCN5-related N-acetyltransferase DAE22_RS12600 ENOG4108SZE gCN5-related N-acetyltransferase DAE22_RS12605 ENOG4107RCC Major Facilitator Superfamily DAE22_RS12610 ENOG4105DIA mandelate racemase muconate lactonizing DAE22_RS12620 ENOG41061P3 phosphosulfolactate synthase DAE22_RS12625 ENOG4108N5B 2-phosphosulfolactate phosphatase DAE22_RS12630 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DAE22_RS12635 ENOG4107RIQ Sulfate adenylate transferase DAE22_RS12640 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DAE22_RS12645 ENOG4107S9D Alpha beta hydrolase DAE22_RS12650 ENOG4105MYW Pentapeptide repeat protein DAE22_RS12655 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DAE22_RS12660 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DAE22_RS12665 ENOG4105SF0 DinB family DAE22_RS12670 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DAE22_RS12675 ENOG4105ETE Transcriptional regulator (LacI family DAE22_RS12680 ENOG4106HBX Transcriptional Regulator AraC Family DAE22_RS12685 ENOG4105UQX Mate efflux family protein DAE22_RS12695 ENOG4105CAQ asparagine synthetase DAE22_RS12705 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DAE22_RS12715 ENOG4105ERH Fumarylacetoacetate hydrolase DAE22_RS12765 ENOG4105EYH Exonuclease DAE22_RS12775 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DAE22_RS12790 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding DAE22_RS12795 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DAE22_RS12800 ENOG4106K7D Major facilitator family transporter DAE22_RS12805 ENOG4108KK1 membrane protein AbrB duplication DAE22_RS12815 ENOG4108INS Transcriptional regulator DAE22_RS12820 ENOG4107SCK Monooxygenase DAE22_RS12835 ENOG41060YP DAE22_RS12840 ENOG4106CAD Protein of unknown function (DUF3311) DAE22_RS12845 ENOG4105E1V na solute symporter DAE22_RS12850 ENOG4105X3H Excalibur domain protein DAE22_RS12855 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DAE22_RS12860 ENOG4105XVF Competence transcription factor DAE22_RS12880 ENOG4106YBV Methyl-accepting chemotaxis DAE22_RS12885 ENOG4107ZYJ bioY protein DAE22_RS12890 ENOG4107F3J Amp-dependent synthetase and ligase DAE22_RS12900 ENOG4107TB6 phosphoglycerate mutase DAE22_RS12905 ENOG4108HUF Transporter DAE22_RS12920 ENOG4105KD7 acetyltransferase DAE22_RS12925 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DAE22_RS12930 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DAE22_RS12940 ENOG4105CEY Amp-dependent synthetase and ligase DAE22_RS12950 ENOG4105DF9 Lipoate-protein, ligase DAE22_RS12955 ENOG4108RQ5 Beta-lactamase domain-containing protein DAE22_RS12960 ENOG4106AXD DAE22_RS12975 ENOG4105DER m42 family DAE22_RS12985 ENOG41090T1 Membrane DAE22_RS12995 ENOG4105ECB domain protein DAE22_RS13005 ENOG4105C1Q protoporphyrinogen oxidase DAE22_RS13010 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DAE22_RS13015 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DAE22_RS13020 ENOG4105BZ4 penicillin-binding protein DAE22_RS13025 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DAE22_RS13060 ENOG4105K59 histidine triad (HIT) protein DAE22_RS13065 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DAE22_RS13070 ENOG4105NBU tryptophan transport protein DAE22_RS13115 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DAE22_RS13125 ENOG4105EQI Metal Dependent Phosphohydrolase DAE22_RS13130 ENOG4106D4I domain protein DAE22_RS13135 ENOG4107VRP DNA repair exonuclease DAE22_RS13140 ENOG4105RHA ABC transporter, permease DAE22_RS13145 ENOG4108IUX (ABC) transporter DAE22_RS13155 ENOG4105CGU Enoyl-CoA hydratase DAE22_RS13165 ENOG4105NCW Trka-c domain protein DAE22_RS13170 ENOG4107S91 Sodium hydrogen exchanger DAE22_RS13175 ENOG4105D4P Coproporphyrinogen iii oxidase DAE22_RS13185 ENOG4105F1N DNA alkylation repair DAE22_RS13190 ENOG4105WZB UPF0342 protein DAE22_RS13195 ENOG4106MP8 UPF0754 membrane protein DAE22_RS13205 ENOG410839P DAE22_RS13230 ENOG4105BZ1 (ABC) transporter DAE22_RS13235 ENOG4105BZ1 (ABC) transporter DAE22_RS13255 ENOG4105F0I Aminotransferase DAE22_RS13260 ENOG4107VMI polysaccharide deacetylase DAE22_RS13265 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DAE22_RS13270 ENOG4105D64 Mechanosensitive ion channel DAE22_RS13280 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DAE22_RS13285 ENOG4105WMR Protein CrcB homolog DAE22_RS13295 ENOG4105C37 (CBS) domain DAE22_RS13300 ENOG4105CHM Aminotransferase DAE22_RS13310 ENOG4105C37 (CBS) domain DAE22_RS13320 ENOG4107VFR oxidoreductase DAE22_RS13325 ENOG4105F6E Acyl-transferase DAE22_RS13330 ENOG4108FN7 Aldo keto reductase DAE22_RS13335 ENOG4108AEY RNA polymerase sigma factor DAE22_RS13340 ENOG4105J37 DAE22_RS13355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DAE22_RS13360 ENOG4105C8J )-transporter DAE22_RS13365 ENOG4105CUB amino acid DAE22_RS13370 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DAE22_RS13375 ENOG4105BZN citrate synthase DAE22_RS13390 ENOG4105G6Z alkaline phosphatase DAE22_RS13395 ENOG4105ED1 spovr family DAE22_RS13430 ENOG4105WH1 Two component transcriptional regulator luxr family DAE22_RS13435 ENOG4105BZU Histidine kinase DAE22_RS13445 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DAE22_RS13450 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DAE22_RS13460 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DAE22_RS13465 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DAE22_RS13475 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DAE22_RS13480 ENOG4107YBY Hydrolase DAE22_RS13485 ENOG41080XP Cbs domain DAE22_RS13495 ENOG4108YBP pseudouridine synthase DAE22_RS13530 ENOG4108IMY Transcriptional regulator DAE22_RS13540 ENOG4108U7W acetyltransferase DAE22_RS13550 ENOG4105BZU Histidine kinase DAE22_RS13560 ENOG4105VEQ Cold shock protein DAE22_RS13565 ENOG4108TU7 Inherit from COG: (ABC) transporter DAE22_RS13570 ENOG4105CJ1 ABC, transporter DAE22_RS13575 ENOG4105CZV ABC transporter DAE22_RS13580 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DAE22_RS13595 ENOG4105CS1 NAD(P)H quinone oxidoreductase DAE22_RS13600 ENOG4105C0R drug resistance transporter emrb qaca subfamily DAE22_RS13605 ENOG4105CW7 secretion protein, HlyD family DAE22_RS13610 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DAE22_RS13615 ENOG4106AKX UPF0229 protein DAE22_RS13620 ENOG4105CYN Serine protein kinase DAE22_RS13640 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DAE22_RS13650 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DAE22_RS13665 ENOG4105VZ8 Transcriptional regulator DAE22_RS13670 ENOG4107D63 DAE22_RS13675 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DAE22_RS13685 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DAE22_RS13690 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DAE22_RS13695 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DAE22_RS13700 ENOG4105E2Y ABC, transporter DAE22_RS13715 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DAE22_RS13720 ENOG4105EC3 peptidase S51, dipeptidase E DAE22_RS13735 ENOG4108N23 SpoOM-related protein DAE22_RS13765 ENOG41087PP glycosyltransferase MGT family DAE22_RS13770 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DAE22_RS13775 ENOG4108KQ6 Enoyl-CoA hydratase DAE22_RS13780 ENOG4108KQ6 Enoyl-CoA hydratase DAE22_RS13785 ENOG4108MGH Enoyl-CoA hydratase DAE22_RS13790 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DAE22_RS13795 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase DAE22_RS13810 ENOG4105C0W non-ribosomal peptide synthetase DAE22_RS13815 ENOG4105C0W non-ribosomal peptide synthetase DAE22_RS13860 ENOG4107SQU synthase DAE22_RS13875 ENOG4108151 Beta-lactamase domain protein DAE22_RS13880 ENOG41062T2 Acyl carrier protein DAE22_RS13885 ENOG4107QKG PfaD family DAE22_RS13895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DAE22_RS13900 ENOG4107QJQ Mate efflux family protein DAE22_RS13905 ENOG4108JA1 polyketide synthase DAE22_RS14020 ENOG4105G5W regulator Fur family DAE22_RS14025 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DAE22_RS14035 ENOG4107NBY Membrane DAE22_RS14040 ENOG4105BZ1 (ABC) transporter DAE22_RS14045 ENOG4105EVI UPF0374 protein DAE22_RS14060 ENOG4105CAN Short-chain dehydrogenase reductase Sdr DAE22_RS14065 ENOG4106BXE DAE22_RS14070 ENOG4105CEN a g-specific adenine glycosylase DAE22_RS14075 ENOG41067AE Membrane-bound metal-dependent hydrolase DAE22_RS14080 ENOG4105EJV Membrane DAE22_RS14085 ENOG4105CKK Glycosyl transferase, family 2 DAE22_RS14090 ENOG4105D74 hydrolase DAE22_RS14095 ENOG4106AKJ DAE22_RS14115 ENOG4105F27 Major Facilitator DAE22_RS14130 ENOG4105ECP epimerase DAE22_RS14145 ENOG4107Y03 Nitroreductase DAE22_RS14150 ENOG4105JAB phenazine biosynthesis protein, phzf family DAE22_RS14155 ENOG4108IHU transport system permease protein DAE22_RS14160 ENOG4105DQ5 transport system permease protein DAE22_RS14165 ENOG4108MES Periplasmic binding protein DAE22_RS14175 ENOG410834F Transcriptional regulator DAE22_RS14180 ENOG4105C0R drug resistance transporter emrb qaca subfamily DAE22_RS14185 ENOG4108YYS metal-dependent hydrolase (By similarity) DAE22_RS14190 ENOG4105H93 Acyltransferase family DAE22_RS14195 ENOG4105CJ1 ABC, transporter DAE22_RS14215 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold DAE22_RS14220 ENOG4105U3E Transcriptional regulator DAE22_RS14230 ENOG4108KYE ABC-2 type transporter DAE22_RS14235 ENOG41090VJ ABC-2 type transporter DAE22_RS14240 ENOG4105CJ1 ABC, transporter DAE22_RS14245 ENOG4105WH1 Two component transcriptional regulator luxr family DAE22_RS14250 ENOG4105BZU Histidine kinase DAE22_RS14255 ENOG4105CIB oxidoreductase Domain protein DAE22_RS14260 ENOG4107QP6 Xylose isomerase domain protein TIM barrel DAE22_RS14265 ENOG4107QNK )-transporter DAE22_RS14270 ENOG4105ID8 Transcriptional regulator, ARAC family DAE22_RS14275 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DAE22_RS14285 ENOG4105BZ1 (ABC) transporter DAE22_RS14290 ENOG4105BZ1 (ABC) transporter DAE22_RS14295 ENOG4105CI1 PTS System DAE22_RS14300 ENOG4108Q3X Transcriptional regulator DAE22_RS14305 ENOG4105F8D glycoside hydrolase family 4 DAE22_RS14330 ENOG4105KK4 UPF0060 membrane protein DAE22_RS14335 ENOG41069DP small acid-soluble spore protein DAE22_RS14340 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DAE22_RS14350 ENOG4107QKR Dehydrogenase DAE22_RS14360 ENOG4107RUY (E1 component), alpha subunit DAE22_RS14380 ENOG4105CFC Transporter DAE22_RS14395 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DAE22_RS14405 ENOG4105D7N magnesium and cobalt transport protein CorA DAE22_RS14410 ENOG4106KE4 Dehydrogenase DAE22_RS14430 ENOG4105D8X mechanosensitive ion channel DAE22_RS14440 ENOG4105UPD Calcium Proton DAE22_RS14445 ENOG4108ISG Major Facilitator DAE22_RS14450 ENOG4107U9T Pfam:Ribonuclease_BN DAE22_RS14460 ENOG4105KJF protein tyrosine phosphatase DAE22_RS14475 ENOG4107RKG DJ-1/PfpI family DAE22_RS14485 ENOG4108RCM Nitroreductase DAE22_RS14490 ENOG4107414 GntR family transcriptional regulator DAE22_RS14495 ENOG4105CG3 alpha amylase, catalytic region DAE22_RS14500 ENOG4105C5Y PTS System DAE22_RS14535 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DAE22_RS14555 ENOG4108RPX mosc domain containing protein DAE22_RS14560 ENOG410855V Acylphosphatase DAE22_RS14585 ENOG4108MRH transcriptional regulatory protein DAE22_RS14595 ENOG4107QPK )-transporter DAE22_RS14600 ENOG4108J20 pectate lyase DAE22_RS14615 ENOG4108HUF Transporter DAE22_RS14620 ENOG4105DQ5 transport system permease protein DAE22_RS14625 ENOG4108U1V ABC transporter, permease DAE22_RS14630 ENOG4105E0A ABC, transporter DAE22_RS14635 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DAE22_RS14645 ENOG4105FDU atp-dependent rna helicase DAE22_RS14650 ENOG4105C5H ABC transporter DAE22_RS14655 ENOG4105DXB Major Facilitator superfamily DAE22_RS14660 ENOG4107SWG transcriptional regulator MERR family DAE22_RS14670 ENOG4105C5H ABC transporter DAE22_RS14675 ENOG4105FKZ Methyl-accepting chemotaxis DAE22_RS14680 ENOG4105C26 Dehydrogenase DAE22_RS14685 ENOG4105CUB amino acid DAE22_RS14695 ENOG4105EU0 Major facilitator Superfamily DAE22_RS14700 ENOG41090R9 glycosyltransferase DAE22_RS14705 ENOG4107R51 Glycosyl transferase, family 2 DAE22_RS14710 ENOG41090R9 glycosyltransferase DAE22_RS14720 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DAE22_RS14725 ENOG4105E0M Sulfatase DAE22_RS14730 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DAE22_RS14735 ENOG4108R1P DAE22_RS14745 ENOG41061H0 Monooxygenase DAE22_RS14750 ENOG41082F9 transcriptional regulator DAE22_RS14755 ENOG4108PCN EamA-like transporter family DAE22_RS14760 ENOG4106I4J membrane DAE22_RS14780 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DAE22_RS14785 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DAE22_RS14790 ENOG4105H67 Protein of unknown function (DUF421) DAE22_RS14795 ENOG4105F8D glycoside hydrolase family 4 DAE22_RS14800 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DAE22_RS14810 ENOG4105E0S extracellular solute-binding protein family 1 DAE22_RS14815 ENOG4105EKC DAE22_RS14825 ENOG4107TDE lipolytic protein G-D-S-L family DAE22_RS14830 ENOG4105CX8 fg-gap repeat protein DAE22_RS14835 ENOG4105CX8 fg-gap repeat protein DAE22_RS14850 ENOG4107TDE lipolytic protein G-D-S-L family DAE22_RS14855 ENOG41075H3 AraC family transcriptional regulator DAE22_RS14860 ENOG4105F5H Glycosyl Hydrolase Family 88 DAE22_RS14865 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DAE22_RS14870 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DAE22_RS14875 ENOG410769Z extracellular solute-binding protein family 1 DAE22_RS14880 ENOG4105EQD regulatoR DAE22_RS14885 ENOG4105C2F Histidine kinase DAE22_RS14900 ENOG4105M18 -acetyltransferase DAE22_RS14905 ENOG4105WEF catalase DAE22_RS14920 ENOG4107S9F NmrA family DAE22_RS14925 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein DAE22_RS14930 ENOG4105M4P Tetr family transcriptional regulator DAE22_RS14940 ENOG4105CDY transcriptional regulatory protein DAE22_RS15010 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DAE22_RS15015 ENOG4105CBD Diacylglycerol kinase DAE22_RS15025 ENOG4108IG5 Transcriptional regulator DAE22_RS15030 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DAE22_RS15035 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DAE22_RS15040 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DAE22_RS15045 ENOG4105CK7 Sodium proline symporter DAE22_RS15050 ENOG4105KT7 mgtC SapB transporter DAE22_RS15055 ENOG4105G6Z alkaline phosphatase DAE22_RS15060 ENOG4105CRN Aminoglycoside phosphotransferase DAE22_RS15090 ENOG4105C1G acyl-Coa dehydrogenase DAE22_RS15105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DAE22_RS15120 ENOG4107S1E Beta-lactamase DAE22_RS15140 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DAE22_RS15145 ENOG4105C4R Atp-dependent dna helicase DAE22_RS15150 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) DAE22_RS15155 ENOG4105CBC glutamate synthase DAE22_RS15160 ENOG4105KGF protein, YerC YecD DAE22_RS15165 ENOG4108R5T secreted protein DAE22_RS15180 ENOG4105DVH amino acid DAE22_RS15190 ENOG4105C12 Phosphoribosylglycinamide synthetase DAE22_RS15195 ENOG4105DC1 bifunctional purine biosynthesis protein purh DAE22_RS15200 ENOG4108V3E phosphoribosylglycinamide formyltransferase DAE22_RS15205 ENOG4105CXB phosphoribosylaminoimidazole synthetase DAE22_RS15215 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii DAE22_RS15220 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DAE22_RS15225 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DAE22_RS15230 ENOG4105C8V SAICAR synthetase DAE22_RS15235 ENOG4105C83 adenylosuccinate lyase DAE22_RS15240 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DAE22_RS15245 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DAE22_RS15270 ENOG4105C7N Xanthine uracil vitamin C permease DAE22_RS15300 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DAE22_RS15310 ENOG4105C85 amino acid DAE22_RS15315 ENOG4107STQ Multicopper oxidase DAE22_RS15325 ENOG4107YUH hydrolase DAE22_RS15355 ENOG4107QNK )-transporter DAE22_RS15360 ENOG4108ZMR Ion transport 2 domain-containing protein DAE22_RS15370 ENOG4105CT4 transporter DAE22_RS15375 ENOG4105CPQ Dehydrogenase DAE22_RS15380 ENOG4105PGZ NB-ARC domain DAE22_RS15390 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DAE22_RS15400 ENOG4108TYN CAAX amino terminal protease family protein DAE22_RS15410 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DAE22_RS15415 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DAE22_RS15420 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DAE22_RS15425 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DAE22_RS15430 ENOG4105C5H ABC transporter DAE22_RS15435 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DAE22_RS15440 ENOG410801F ribosomal-protein-alanine acetyltransferase DAE22_RS15445 ENOG41072GX Peptidase M22 Glycoprotease DAE22_RS15450 ENOG4105K8N protein family UPF0079, ATPase DAE22_RS15455 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DAE22_RS15500 ENOG4105D3P Mannan endo-1,4-beta-mannosidase DAE22_RS15505 ENOG4105DG6 mannose-6-phosphate isomerase DAE22_RS15510 ENOG4105EVU fructokinase DAE22_RS15515 ENOG4108TZY GntR Family Transcriptional Regulator DAE22_RS15520 ENOG4105CS2 ec 3.2.1.21 DAE22_RS15525 ENOG4105CK1 PTS System DAE22_RS15530 ENOG4105VCP PTS System DAE22_RS15535 ENOG4105VZJ PTS System DAE22_RS15540 ENOG4105F27 Major Facilitator DAE22_RS15545 ENOG41090UD (LipO)protein DAE22_RS15550 ENOG4107TVP HD domain protein DAE22_RS15555 ENOG4108YM7 Gcn5-related n-acetyltransferase DAE22_RS15565 ENOG4108ZMX Domain of unknown function (DU1801) DAE22_RS15570 ENOG4105G6Z alkaline phosphatase DAE22_RS15585 ENOG4105VRS hydrolase family 18 DAE22_RS15590 ENOG4105DRR Transcriptional regulator, GntR family DAE22_RS15600 ENOG4105C2C drug resistance transporter, Bcr CflA DAE22_RS15615 ENOG4108JCI Transcriptional regulator DAE22_RS15620 ENOG4105FS7 Transcriptional regulator DAE22_RS15625 ENOG4108TVJ Nitroreductase DAE22_RS15630 ENOG4105CHR reductase DAE22_RS15640 ENOG4105EYF MMPL domain protein DAE22_RS15645 ENOG41062A4 Transcriptional regulator DAE22_RS15655 ENOG4105C85 amino acid DAE22_RS15665 ENOG4105VN1 Heat shock protein DAE22_RS15675 ENOG4105C54 Major Facilitator superfamily DAE22_RS15680 ENOG4105ETE Transcriptional regulator (LacI family DAE22_RS15685 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DAE22_RS15690 ENOG4105WQG acetyltransferase DAE22_RS15700 ENOG4105PF9 Transcriptional regulator DAE22_RS15710 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DAE22_RS15715 ENOG4105XXY Thioredoxin DAE22_RS15720 ENOG4108VGI doxx family DAE22_RS15725 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DAE22_RS15730 ENOG4108TVJ Nitroreductase DAE22_RS15735 ENOG41076HS cation diffusion facilitator family transporter DAE22_RS15740 ENOG4108Z5V transcriptional regulator, merr family DAE22_RS15745 ENOG4108UQV Membrane DAE22_RS15750 ENOG4105EYF MMPL domain protein DAE22_RS15755 ENOG4108VB1 regulatoR DAE22_RS15760 ENOG4105ENE Histidine kinase DAE22_RS15775 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DAE22_RS15780 ENOG4108ZHR arsR family transcriptional regulator DAE22_RS15785 ENOG4108SQ9 flavin reductase domain protein, FMN-binding DAE22_RS15795 ENOG4107Y9U Membrane DAE22_RS15800 ENOG4107TXC Transcriptional regulator DAE22_RS15805 ENOG4107R5R arsenical pump membrane protein DAE22_RS15810 ENOG41082YX Transcriptional regulator, arsr family DAE22_RS15815 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DAE22_RS15830 ENOG4107Z6X Transcriptional regulator DAE22_RS15835 ENOG4105MJ9 esterase DAE22_RS15840 ENOG4108ZMQ domain protein DAE22_RS15845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DAE22_RS15850 ENOG4105T38 integral membrane protein DAE22_RS15860 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein DAE22_RS15865 ENOG4105C9Q fumarate hydratase class II DAE22_RS15870 ENOG4107RSM transcriptional regulator DAE22_RS15880 ENOG4105CTU Proline racemase DAE22_RS15890 ENOG4108JYZ YitT family DAE22_RS15895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DAE22_RS15900 ENOG4105US7 Histidine kinase DAE22_RS15920 ENOG4105Z7P Acetyltransferase (GNAT) family DAE22_RS15925 ENOG4105ST3 Transcriptional regulator DAE22_RS15930 ENOG4105KRI phosphocarrier protein (HPr DAE22_RS15935 ENOG4105F27 Major Facilitator DAE22_RS15940 ENOG4105CZ9 Domain of unknown function (DU1801) DAE22_RS15950 ENOG41086D8 Transcriptional regulator DAE22_RS15955 ENOG4108VJ1 Transcriptional regulator (CarD family DAE22_RS15960 ENOG4105VEQ Cold shock protein DAE22_RS15970 ENOG4105DJ2 Major Facilitator Superfamily DAE22_RS15995 ENOG4105VZ8 Transcriptional regulator DAE22_RS16010 ENOG4108594 Permease of the drug metabolite transporter DAE22_RS16015 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DAE22_RS16035 ENOG41090E6 transcriptional regulator MERR family DAE22_RS16045 ENOG4105EA8 2-Nitropropane dioxygenase DAE22_RS16050 ENOG4105K56 Transcriptional regulator DAE22_RS16115 ENOG41064BQ Phosphatase DAE22_RS16125 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DAE22_RS16130 ENOG4105WN5 stage II sporulation protein DAE22_RS16135 ENOG4107SGM protein serine threonine phosphatase DAE22_RS16140 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase DAE22_RS16145 ENOG4105FUA antagonist DAE22_RS16150 ENOG4107MMM Anti-sigma-factor antagonist DAE22_RS16155 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DAE22_RS16165 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DAE22_RS16170 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DAE22_RS16175 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DAE22_RS16185 ENOG4105CKV Membrane DAE22_RS16190 ENOG410905X membrane-flanked domain protein DAE22_RS16195 ENOG4105C1J atp-dependent rna helicase DAE22_RS16200 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DAE22_RS16205 ENOG4105CPF Cell wall formation (By similarity) DAE22_RS16210 ENOG4105SZ6 Thioredoxin DAE22_RS16230 ENOG4105FDT acyl-CoA dehydrogenase DAE22_RS16245 ENOG4105CJ1 ABC, transporter DAE22_RS16255 ENOG4106F5Q Membrane DAE22_RS16260 ENOG4107QJT sodium dicarboxylate symporter DAE22_RS16265 ENOG4108MRH transcriptional regulatory protein DAE22_RS16270 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DAE22_RS16275 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DAE22_RS16290 ENOG41082W1 Cupin 2, conserved barrel domain protein DAE22_RS16295 ENOG4105QVS general stress protein DAE22_RS16300 ENOG4105EU9 DAE22_RS16305 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) DAE22_RS16310 ENOG4107BMA Transglycosylase associated protein DAE22_RS16315 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DAE22_RS16335 ENOG4105C0X amino acid DAE22_RS16345 ENOG4107R8N Glycosyl transferase, family 2 DAE22_RS16350 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DAE22_RS16365 ENOG4105C9U ATP-dependent DNA helicase RecQ DAE22_RS16375 ENOG4105VCH membrane DAE22_RS16385 ENOG410606W general stress protein DAE22_RS16400 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DAE22_RS16405 ENOG4105HMZ Methyltransferase DAE22_RS16415 ENOG4105ETD TRANSCRIPTIONal DAE22_RS16420 ENOG4107QM2 Aldo Keto reductase DAE22_RS16425 ENOG4107RVG penicillin-binding protein DAE22_RS16430 ENOG41061CK Antibiotic biosynthesis monooxygenase DAE22_RS16440 ENOG4105XJB lipolytic protein G-D-S-L family DAE22_RS16445 ENOG4107258 Transcriptional regulator DAE22_RS16455 ENOG4105P4J Allophanate hydrolase, subunit 1 DAE22_RS16460 ENOG4105CFM UPF0317 protein DAE22_RS16465 ENOG4105C5A transporter DAE22_RS16470 ENOG4105E7W lamb ycsf family protein DAE22_RS16495 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DAE22_RS16515 ENOG4108ZYE Transcriptional regulator DAE22_RS16520 ENOG4108T5E Copper resistance protein DAE22_RS16525 ENOG4105KTB nuclear export factor GLE1 DAE22_RS16530 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DAE22_RS16540 ENOG4105C26 Dehydrogenase DAE22_RS16545 ENOG4108JPW Aminotransferase DAE22_RS16555 ENOG4105YVS arsR family transcriptional regulator DAE22_RS16560 ENOG41067V3 Antibiotic biosynthesis monooxygenase DAE22_RS16565 ENOG4108DBC nitroreductase DAE22_RS16570 ENOG4105R8C Transcriptional regulator DAE22_RS16585 ENOG4108IPW abc transporter atp-binding protein DAE22_RS16590 ENOG4105CM4 permease protein DAE22_RS16595 ENOG4105DHS permease protein DAE22_RS16600 ENOG4105CFH Aspartokinase DAE22_RS16620 ENOG4105BZU Histidine kinase DAE22_RS16625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DAE22_RS16630 ENOG4107WD8 ABC transporter, permease DAE22_RS16650 ENOG4105E1K spore germination protein DAE22_RS16665 ENOG4105DUX Transporter DAE22_RS16675 ENOG41069ZX DAE22_RS16680 ENOG41069ZX DAE22_RS16685 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DAE22_RS16690 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DAE22_RS16695 ENOG4106P55 Transcriptional regulator DAE22_RS16705 ENOG4105DRP amino acid AbC transporter DAE22_RS16710 ENOG4105CDA abc transporter atp-binding protein DAE22_RS16720 ENOG4105W8Z 4'-phosphopantetheinyl transferase DAE22_RS16730 ENOG4105SX7 Transporter DAE22_RS16760 ENOG4105CEY Amp-dependent synthetase and ligase DAE22_RS16765 ENOG4105KVH Transcriptional regulator DAE22_RS16770 ENOG4108VA3 3-hexulose-6-phosphate synthase DAE22_RS16775 ENOG41080HJ 6-phospho 3-hexuloisomerase DAE22_RS16780 ENOG4105C8Q Methyl-accepting chemotaxis DAE22_RS16795 ENOG4105CS2 ec 3.2.1.21 DAE22_RS16800 ENOG4108VEN abc transporter atp-binding protein DAE22_RS16810 ENOG4105K56 Transcriptional regulator DAE22_RS16820 ENOG4105HHM rdd domain containing protein DAE22_RS16830 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein DAE22_RS16835 ENOG4105E5Q amino acid AbC transporter DAE22_RS16840 ENOG4105CKI cobalamin synthesis protein DAE22_RS16850 ENOG4105S7A ErfK ybiS ycfS ynhG family protein DAE22_RS16870 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DAE22_RS16875 ENOG4108IFG nitrite reductase, (NAD(P)H) DAE22_RS16880 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DAE22_RS16885 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DAE22_RS16900 ENOG4108PJD permease DAE22_RS16910 ENOG4107YHD transcriptional regulator DAE22_RS16915 ENOG4105CK7 Sodium proline symporter DAE22_RS16920 ENOG4105C26 Dehydrogenase DAE22_RS16930 ENOG410756H nucleotidyltransferase DAE22_RS16935 ENOG4105I82 acetyl xylan esterase DAE22_RS16940 ENOG4105C5Q Transcriptional regulator DAE22_RS16945 ENOG41089UC methyltransferase, type 11 DAE22_RS16950 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DAE22_RS16955 ENOG4105I1F Resistance protein DAE22_RS16960 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DAE22_RS16965 ENOG4105EIG urea carboxylase-associated protein 1 DAE22_RS17000 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DAE22_RS17030 ENOG4107SQ8 Glycine betaine DAE22_RS17035 ENOG4108IJ7 Glycine betaine DAE22_RS17040 ENOG4108A65 Transcriptional regulator DAE22_RS17045 ENOG4107XZQ multidrug resistance protein DAE22_RS17050 ENOG41079KZ Major Facilitator Superfamily DAE22_RS17060 ENOG4108TTB tellurium resistance protein DAE22_RS17065 ENOG4107TS3 membrane protein, TerC DAE22_RS17070 ENOG4106FN3 tellurium resistance protein DAE22_RS17075 ENOG4106FN3 tellurium resistance protein DAE22_RS17080 ENOG4108N0M stress protein DAE22_RS17085 ENOG4105DEN Luciferase family DAE22_RS17095 ENOG4105DIK (ABC) transporter DAE22_RS17100 ENOG4105DSE periplasmic solute binding protein DAE22_RS17110 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DAE22_RS17145 ENOG4107SET aldo keto reductase DAE22_RS17150 ENOG4108SDH ABC, transporter DAE22_RS17155 ENOG4108IUW ABC transporter DAE22_RS17160 ENOG4107Y7X LytTR DAE22_RS17170 ENOG41060AI SEC-C motif DAE22_RS17180 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold DAE22_RS17185 ENOG4107RB3 L-asparaginase DAE22_RS17190 ENOG4105J7D transcriptional regulator DAE22_RS17195 ENOG4105C0R drug resistance transporter emrb qaca subfamily DAE22_RS17200 ENOG4107EPV Aminotransferase class V DAE22_RS17205 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) DAE22_RS17210 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DAE22_RS17215 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DAE22_RS17220 ENOG4105DGI Alkaline phosphatase DAE22_RS17230 ENOG4105MUA Resistance protein DAE22_RS17270 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DAE22_RS17275 ENOG4106UX7 integral membrane protein DAE22_RS17290 ENOG4105CTX dehydratase DAE22_RS17295 ENOG41073TP transcriptional regulator DAE22_RS17300 ENOG4105EQX glucarate dehydratase DAE22_RS17305 ENOG4105DJB Major Facilitator Superfamily DAE22_RS17310 ENOG4105C26 Dehydrogenase DAE22_RS17315 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase DAE22_RS17330 ENOG4105CSV Glutaminase DAE22_RS17340 ENOG4108J5H Homocysteine s-methyltransferase DAE22_RS17345 ENOG4108IQI permease DAE22_RS17350 ENOG4105CM2 brancheD-chain amino acid aminotransferase DAE22_RS17365 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DAE22_RS17370 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane DAE22_RS17380 ENOG4105C72 UPF0176 protein DAE22_RS17405 ENOG4107ZTW SNARE associated Golgi DAE22_RS17410 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DAE22_RS17415 ENOG4108WC5 Alpha Beta Hydrolase Fold protein DAE22_RS17425 ENOG4108TCS Glutamyl endopeptidase DAE22_RS17430 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DAE22_RS17435 ENOG4106AXJ AraC family transcriptional regulator DAE22_RS17440 ENOG410631K Membrane DAE22_RS17455 ENOG4105DCM major facilitator superfamily DAE22_RS17460 ENOG410645S MarR family Transcriptional regulator DAE22_RS17470 ENOG4105CXY transporter DAE22_RS17475 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DAE22_RS17485 ENOG4107QTZ amino acid DAE22_RS17495 ENOG4107E6A Cytochrome p-450 DAE22_RS17500 ENOG4108HWY Beta-lactamase DAE22_RS17510 ENOG4106DDH Sporulation-specific SASP protein DAE22_RS17520 ENOG4106K80 DAE22_RS17530 ENOG4105G0J serine threonine protein kinase DAE22_RS17570 ENOG4108RWP Major Facilitator Superfamily protein DAE22_RS17575 ENOG4105WAB arsR family transcriptional regulator DAE22_RS17580 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DAE22_RS17600 ENOG4108TWJ NADH dehydrogenase subunit 5 DAE22_RS17610 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DAE22_RS17615 ENOG4107U5W ybbr family DAE22_RS17620 ENOG4105C8B TIGR00159 family DAE22_RS17630 ENOG4105EMN RNA polymerase sigma factor DAE22_RS17660 ENOG4105EWC Purine nucleoside phosphorylase DAE22_RS17670 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DAE22_RS17690 ENOG4105D17 glycoside hydrolase, family 3 domain protein DAE22_RS17695 ENOG4105EHZ conserved protein UCP016719 DAE22_RS17700 ENOG410874W AraC family transcriptional regulator DAE22_RS17720 ENOG4108SA1 esterase DAE22_RS17730 ENOG4105CHH sulfate transporter DAE22_RS17735 ENOG4105CPQ Dehydrogenase DAE22_RS17745 ENOG4108JPW Aminotransferase DAE22_RS17830 ENOG4108NMV polysaccharide deacetylase DAE22_RS17845 ENOG4105D1F ATP-binding protein DAE22_RS17860 ENOG4108I0C methyltransferase DAE22_RS17865 ENOG4108UJD 30S ribosomal protein S9 DAE22_RS17870 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DAE22_RS17875 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DAE22_RS17880 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DAE22_RS17885 ENOG4108JJB ABC transporter DAE22_RS17890 ENOG4108JJB ABC transporter DAE22_RS17895 ENOG4108ZT0 50S ribosomal protein l17 DAE22_RS17900 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DAE22_RS17905 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DAE22_RS17910 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DAE22_RS17915 ENOG41067V7 50S ribosomal protein L36 DAE22_RS17925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DAE22_RS17935 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DAE22_RS17940 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DAE22_RS17950 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DAE22_RS17955 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DAE22_RS17960 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DAE22_RS17965 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DAE22_RS17975 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DAE22_RS17985 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DAE22_RS17990 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DAE22_RS18000 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DAE22_RS18005 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DAE22_RS18020 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DAE22_RS18030 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DAE22_RS18035 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DAE22_RS18040 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DAE22_RS18045 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DAE22_RS18050 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DAE22_RS18055 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DAE22_RS18060 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DAE22_RS18065 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DAE22_RS18070 ENOG4105XPM ribosomal protein DAE22_RS18075 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DAE22_RS18080 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DAE22_RS18085 ENOG4107Y49 methyltransferase DAE22_RS18095 ENOG4108VZM 50s ribosomal protein L10 DAE22_RS18110 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DAE22_RS18130 ENOG4105M0M Tetracycline resistance protein DAE22_RS18135 ENOG4105C2N RNA methyltransferase TrmH family group 3 DAE22_RS18140 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) DAE22_RS18145 ENOG4105C8N cysteinyl-tRNA synthetase DAE22_RS18150 ENOG4105D7W serine acetyltransferase DAE22_RS18155 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DAE22_RS18160 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DAE22_RS18165 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DAE22_RS18170 ENOG4105CTP PilT protein domain protein DAE22_RS18175 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DAE22_RS18180 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DAE22_RS18190 ENOG41066A3 ATP guanido phosphotransferase DAE22_RS18195 ENOG4108Z0C Uvrb UvrC protein DAE22_RS18280 ENOG4105CRK lysyL-tRNA synthetase DAE22_RS18285 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DAE22_RS18295 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DAE22_RS18300 ENOG4105KRF dihydroneopterin aldolase DAE22_RS18305 ENOG4105EEI dihydropteroate synthase DAE22_RS18310 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DAE22_RS18315 ENOG4105DDQ anthranilate synthase DAE22_RS18320 ENOG4105CRQ synthase (Component I) DAE22_RS18325 ENOG4105C6T cysteine synthase DAE22_RS18330 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase DAE22_RS18335 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DAE22_RS18345 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DAE22_RS18350 ENOG4108UGV hypoxanthine phosphoribosyltransferase DAE22_RS18355 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DAE22_RS18385 ENOG41060GV RNA binding s1 domain protein DAE22_RS18400 ENOG4105VYY sporulation protein yabp DAE22_RS18405 ENOG41082I2 s4 domain protein DAE22_RS18410 ENOG4108IY2 MazG family DAE22_RS18420 ENOG4108M14 stage v sporulation protein t DAE22_RS18425 ENOG4108JA2 transcriptioN-repair coupling factor DAE22_RS18435 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DAE22_RS18440 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DAE22_RS18445 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DAE22_RS18450 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DAE22_RS18455 ENOG4105K4W Could be involved in septation (By similarity) DAE22_RS18460 ENOG4105KME endoribonuclease L-psp DAE22_RS18465 ENOG4105DFT pur operon repressor DAE22_RS18470 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DAE22_RS18475 ENOG4105XEW small acid-soluble spore protein DAE22_RS18480 ENOG4105W42 Veg protein DAE22_RS18485 ENOG4105XFA sporulation peptidase YabG DAE22_RS18490 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DAE22_RS18500 ENOG41069ER domain protein DAE22_RS18505 ENOG4105F8V Hydrolase, tatD family DAE22_RS18510 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DAE22_RS18515 ENOG4105KRN Transcriptional regulator, abrb family DAE22_RS18520 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DAE22_RS18525 ENOG4105VC4 domain protein DAE22_RS18530 ENOG41060K3 Methyltransferase DAE22_RS18535 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) DAE22_RS18540 ENOG4105MA4 psp1 domain protein DAE22_RS18545 ENOG4105FA2 dna polymerase iii DAE22_RS18550 ENOG4105XVJ Protein of unknown function (DUF327) DAE22_RS18555 ENOG4105X0R protein from nitrogen regulatory protein P-II DAE22_RS18560 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DAE22_RS18565 ENOG4105CXN decarboxylase DAE22_RS18570 ENOG4105CDW Resistance protein DAE22_RS18610 ENOG41067KS pro-sigma K processing DAE22_RS18620 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DAE22_RS18625 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DAE22_RS18630 ENOG4105C6E dna polymerase iii DAE22_RS18640 ENOG4108Z6B deaminase DAE22_RS18645 ENOG4105GTG Isochorismatase DAE22_RS18650 ENOG4105VRS hydrolase family 18 DAE22_RS18660 ENOG4105ZMH deoxynucleoside kinase DAE22_RS18670 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DAE22_RS18675 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DAE22_RS18680 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) DAE22_RS18690 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DAE22_RS18725 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DAE22_RS18730 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DAE22_RS18745 ENOG410848D S4 domain protein YaaA DAE22_RS18750 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DAE22_RS18755 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DAE22_RS18765 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DAE22_RS18780 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DAE22_RS18785 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DAE22_RS18790 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) DAE22_RS18805 ENOG4107QJE Chromosome Partitioning Protein DAE22_RS18810 ENOG4105FA0 parb-like partition protein DAE22_RS18815 ENOG4108ZDA Sporulation protein YyaC DAE22_RS18825 ENOG4105VDK protein, conserved in bacteria DAE22_RS18830 ENOG4108J2R molybdopterin oxidoreductase DAE22_RS18835 ENOG4105C3G gtp-binding protein DAE22_RS18840 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DAE22_RS18845 ENOG4108UUM single-stranded DNA-binding protein DAE22_RS18850 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DAE22_RS18855 ENOG4105CGK Exodeoxyribonuclease III DAE22_RS18865 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DAE22_RS18875 ENOG4107FCW Abortive infection protein DAE22_RS18880 ENOG4105C7Z Conserved Protein DAE22_RS18890 ENOG41068WC Domain of unknown function (DUF955) DAE22_RS18895 ENOG4108IMY Transcriptional regulator DAE22_RS18910 ENOG4107SWG transcriptional regulator MERR family DAE22_RS18920 ENOG4105UNS Pfam:DUF419 DAE22_RS18945 ENOG41082BV acetyltransferase DAE22_RS18950 ENOG4108U05 Transcriptional regulator DAE22_RS18955 ENOG4105KVH Transcriptional regulator DAE22_RS18965 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase DAE22_RS18975 ENOG4108VP3 Lysine exporter protein (LysE YggA) DAE22_RS18980 ENOG4107V2S Transcriptional regulator DAE22_RS18990 ENOG41082BV acetyltransferase DAE22_RS18995 ENOG4107RSM transcriptional regulator DAE22_RS19000 ENOG4105D94 Major Facilitator Superfamily DAE22_RS19005 ENOG4105DDN Pentapeptide repeat-containing protein DAE22_RS19010 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein DAE22_RS19030 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase DAE22_RS19035 ENOG4105KVH Transcriptional regulator DAE22_RS19050 ENOG4108XMW Membrane DAE22_RS19055 ENOG4105BZR domain protein DAE22_RS19060 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DAE22_RS19065 ENOG4105EDW glycosyl transferase, family 39 DAE22_RS19070 ENOG4105DJ2 Major Facilitator Superfamily DAE22_RS19090 ENOG4105CDU Replicative dna helicase DAE22_RS19095 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DAE22_RS19100 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DAE22_RS19125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DAE22_RS19130 ENOG4105BZU Histidine kinase DAE22_RS19145 ENOG4105Q2H domain protein DAE22_RS19150 ENOG4105C0H protease DAE22_RS19175 ENOG4105BZU Histidine kinase DAE22_RS19180 ENOG4108JUB Transcriptional regulator DAE22_RS19185 ENOG4105C8Y Acetylornithine aminotransferase DAE22_RS19190 ENOG4108IQI permease DAE22_RS19195 ENOG41066UZ arginase EC 3.5.3.1 DAE22_RS19205 ENOG410780I phosphoprotein phosphatase activity DAE22_RS19210 ENOG4105WQG acetyltransferase DAE22_RS19215 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) DAE22_RS19235 ENOG4105E2A Dehydrogenase DAE22_RS19250 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DAE22_RS19265 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 DAE22_RS19270 ENOG4108S3Y transcriptional regulator DAE22_RS19275 ENOG4105C5Y PTS System DAE22_RS19280 ENOG4105CS2 ec 3.2.1.21 DAE22_RS19290 ENOG4108JU3 Alkyl hydroperoxide reductase DAE22_RS19295 ENOG4105D3R alkyl hydroperoxide reductase DAE22_RS19300 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DAE22_RS19305 ENOG4105C6Z Gluconate DAE22_RS19310 ENOG4105CMG Carbohydrate kinase DAE22_RS19315 ENOG4105G3Z GntR family transcriptional regulator DAE22_RS19320 ENOG4105BZW Glycerate kinase DAE22_RS19345 ENOG41067MG lrgb family DAE22_RS19355 ENOG41061AU MarR family Transcriptional regulator DAE22_RS19360 ENOG4107JEE Short-chain dehydrogenase reductase Sdr DAE22_RS19365 ENOG4105J7D transcriptional regulator DAE22_RS19380 ENOG41085PJ rdd domain containing protein DAE22_RS19390 ENOG4107SET aldo keto reductase DAE22_RS19400 ENOG4105C26 Dehydrogenase DAE22_RS19405 ENOG4105ST3 Transcriptional regulator DAE22_RS19410 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DAE22_RS19420 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DAE22_RS19425 ENOG4107QNK )-transporter DAE22_RS19445 ENOG4105DJB Major Facilitator Superfamily DAE22_RS19460 ENOG4105CPC Aldo Keto reductase DAE22_RS19470 ENOG4105C26 Dehydrogenase DAE22_RS19480 ENOG4105D7K pfkb domain protein DAE22_RS19485 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) DAE22_RS19490 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DAE22_RS19500 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DAE22_RS19505 ENOG4105F0H myo-inositol catabolism protein DAE22_RS19510 ENOG4107TRN Xylose isomerase domain protein TIM barrel DAE22_RS19515 ENOG4105D2N Aldolase DAE22_RS19545 ENOG4108V5C ABC transporter DAE22_RS19575 ENOG410667J hydrolase DAE22_RS19580 ENOG4107QHE Choloylglycine hydrolase DAE22_RS19595 ENOG4105EAB amino acid AbC transporter DAE22_RS19600 ENOG4108HW4 amino acid AbC transporter DAE22_RS19615 ENOG4108PGP mmge prpd family protein DAE22_RS19620 ENOG4105ENY Ethanolamine utilization protein eutH DAE22_RS19625 ENOG4108TM9 integral membrane protein DAE22_RS19630 ENOG4107RHR regulatoR DAE22_RS19640 ENOG4105D9N nucleoside DAE22_RS19645 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DAE22_RS19655 ENOG4107W25 arginase agmatinase formiminoglutamase DAE22_RS19660 ENOG4105CI2 imidazolone-5-propionate hydrolase DAE22_RS19665 ENOG4105CGP Urocanate hydratase DAE22_RS19670 ENOG4105C84 Histidine ammonia-lyase DAE22_RS19685 ENOG4106Z5D Glycoside Hydrolase Family 43 DAE22_RS19720 ENOG4107EV6 Inherit from COG: YD repeat protein DAE22_RS19760 ENOG4105C5Y PTS System DAE22_RS19765 ENOG4105CS2 ec 3.2.1.21 DAE22_RS19770 ENOG4107YZX Universal stress protein DAE22_RS19775 ENOG4107TS3 membrane protein, TerC DAE22_RS19870 ENOG4107TDE lipolytic protein G-D-S-L family DAE22_RS19875 ENOG4105C1J atp-dependent rna helicase DAE22_RS19880 ENOG4105DEU major facilitator superfamily DAE22_RS19890 ENOG4105CID antiterminator DAE22_RS19895 ENOG4105C5Y PTS System DAE22_RS19900 ENOG4105CS2 ec 3.2.1.21 DAE22_RS19905 ENOG4108RZ2 Glycoside hydrolase family 16 DAE22_RS19910 ENOG4105D4T Citrate transporter DAE22_RS19915 ENOG4105CH6 catalase DAE22_RS19935 ENOG4105DHI Methyltransferase DAE22_RS19940 ENOG4105CY2 Citrate transporter DAE22_RS19945 ENOG4105D6N CoA-transferase, subunit a DAE22_RS19950 ENOG4108IIH CoA-transferase subunit B DAE22_RS19955 ENOG4105DTD Dehydrogenase DAE22_RS19980 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DAE22_RS19985 ENOG4105WH1 Two component transcriptional regulator luxr family DAE22_RS19990 ENOG4105BZU Histidine kinase DAE22_RS20000 ENOG4105CMR udp-glucose 4-epimerase DAE22_RS20010 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DAE22_RS20035 ENOG4107BJW polysaccharide deacetylase DAE22_RS20045 ENOG4105D2K citrate carrier protein DAE22_RS20050 ENOG4105C4M (Ubiquinol oxidase) subunit I DAE22_RS20055 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DAE22_RS20060 ENOG4108JJ9 ABC, transporter DAE22_RS20065 ENOG4108JJ8 (ABC) transporter DAE22_RS20070 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DAE22_RS20075 ENOG4105ETS cytosine purines uracil thiamine allantoin DAE22_RS20095 ENOG41069JR DAE22_RS20100 ENOG4105DA5 (ABC) transporter DAE22_RS20115 ENOG4105CH6 catalase DAE22_RS20120 ENOG4108VX5 3-methyladenine DNA glycosylase DAE22_RS20130 ENOG4105EMD TRANSCRIPTIONal DAE22_RS20135 ENOG4105VZJ PTS System DAE22_RS20140 ENOG4105CK1 PTS System DAE22_RS20145 ENOG4105VCP PTS System DAE22_RS20150 ENOG4105F8D glycoside hydrolase family 4 DAE22_RS20155 ENOG4105CM2 brancheD-chain amino acid aminotransferase DAE22_RS20160 ENOG4108VHC Short-chain dehydrogenase reductase Sdr DAE22_RS20165 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DAE22_RS20175 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DAE22_RS20180 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) DAE22_RS20195 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DAE22_RS20220 ENOG4105IIU Aminopeptidase DAE22_RS20230 ENOG4105GVJ transcriptional regulator DAE22_RS20240 ENOG4105X1N Glycosyl transferase family 8 DAE22_RS20255 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin DAE22_RS20260 ENOG4105CK1 PTS System DAE22_RS20265 ENOG4108YV3 Protein of unknown function (DUF2711) DAE22_RS20275 ENOG4105DR4 Methyltransferase DAE22_RS20285 ENOG4105D8G Major Facilitator superfamily DAE22_RS20290 ENOG41067MG lrgb family DAE22_RS20295 ENOG4105VAW lrga family DAE22_RS20300 ENOG4105CMU LysR family (Transcriptional regulator DAE22_RS20310 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DAE22_RS20315 ENOG4107SJW iron permease, FTR1 DAE22_RS20320 ENOG410650H (LipO)protein DAE22_RS20325 ENOG4105DBE peroxidase DAE22_RS20330 ENOG4107ZXU DSBA oxidoreductase DAE22_RS20355 ENOG4105WH5 Teichoic acid glycosylation protein DAE22_RS20360 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DAE22_RS20370 ENOG4107BMA Transglycosylase associated protein DAE22_RS20375 ENOG4105E2S oxidase) subunit II DAE22_RS20405 ENOG4108DBC nitroreductase DAE22_RS20410 ENOG4105DEN Luciferase family DAE22_RS20415 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DAE22_RS20430 ENOG4108QTI )-transporter DAE22_RS20435 ENOG4105C5Y PTS System DAE22_RS20450 ENOG4105DWF phosphomethylpyrimidine kinase DAE22_RS20455 ENOG4108RJ9 Glycosyl transferase, family 2 DAE22_RS20460 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DAE22_RS20465 ENOG4105C26 Dehydrogenase DAE22_RS20500 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DAE22_RS20500 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DAE22_RS20505 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD DAE22_RS20515 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DAE22_RS20520 ENOG4105C1B dTDP-glucose 4-6-dehydratase DAE22_RS20525 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DAE22_RS20530 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase DAE22_RS20540 ENOG4105D82 Glutamate dehydrogenase DAE22_RS20545 ENOG4105C26 Dehydrogenase DAE22_RS20560 ENOG4105FCW Major Facilitator superfamily DAE22_RS20565 ENOG41061WN bacilysin biosynthesis protein DAE22_RS20570 ENOG4106CHD Bacilysin biosynthesis protein bacB DAE22_RS20575 ENOG4105CHR reductase DAE22_RS20580 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase DAE22_RS20590 ENOG4105CHM Aminotransferase DAE22_RS20605 ENOG4108IJ2 phosphate acetyltransferase DAE22_RS20610 ENOG4105DUM transcriptional regulator, lysR family DAE22_RS20615 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DAE22_RS20625 ENOG4108RNG Permease of the drug metabolite transporter DAE22_RS20630 ENOG4108VCI transcription factor, rsfa family DAE22_RS20640 ENOG4105DCI Phosphohydrolase DAE22_RS20650 ENOG41062ES Transcriptional regulator DAE22_RS20665 ENOG4105C22 threonyL-tRNA synthetase DAE22_RS20670 ENOG41067TZ transcriptional regulator, MarR family DAE22_RS20675 ENOG41069HH 4-oxalocrotonate tautomerase DAE22_RS20680 ENOG4108Z4T Peptidase M50 DAE22_RS20685 ENOG4108XFG YwhD family DAE22_RS20690 ENOG4105BZ4 penicillin-binding protein DAE22_RS20695 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DAE22_RS20700 ENOG4105CYW agmatinase DAE22_RS20715 ENOG4107JM4 Tetratricopeptide repeat DAE22_RS20760 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E DAE22_RS20775 ENOG410684U Domain of unknown function (DUF1934) DAE22_RS20780 ENOG4105C75 arginyL-tRNA synthetase DAE22_RS20790 ENOG4107V6Q Cyclic nucleotide-binding domain DAE22_RS20810 ENOG4108IUE nitrate reductase beta subunit DAE22_RS20815 ENOG4105R3A Nitrate reductase DAE22_RS20830 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DAE22_RS20835 ENOG4105BZ1 (ABC) transporter DAE22_RS20840 ENOG4105NAE bifunctional deaminase-reductase domain protein DAE22_RS20850 ENOG4105E5J UV damage endonuclease DAE22_RS20860 ENOG4105DF6 Fe-S oxidoreductase DAE22_RS20865 ENOG4105C1G acyl-Coa dehydrogenase DAE22_RS20875 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DAE22_RS20885 ENOG410812K response regulator receiver protein DAE22_RS20890 ENOG4105D2N Aldolase DAE22_RS20895 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway DAE22_RS20900 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DAE22_RS20905 ENOG4105CBT Fructose-1,6-bisphosphatase DAE22_RS20915 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DAE22_RS20925 ENOG4107104 thymidine kinase DAE22_RS20930 ENOG4105C6K Malic enzyme DAE22_RS20935 ENOG4107TT2 Auxin Efflux Carrier DAE22_RS20945 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DAE22_RS20950 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DAE22_RS20955 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DAE22_RS20970 ENOG4108ZXQ stage ii sporulation protein r DAE22_RS20980 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DAE22_RS20985 ENOG410815N Probably functions as a manganese efflux pump (By similarity) DAE22_RS20990 ENOG4107WAU Protein tyrosine phosphatase DAE22_RS20995 ENOG4108YZG isomerase DAE22_RS21000 ENOG4108UIC UPF0340 protein DAE22_RS21005 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DAE22_RS21010 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DAE22_RS21020 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) DAE22_RS21040 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DAE22_RS21045 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DAE22_RS21050 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DAE22_RS21055 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DAE22_RS21065 ENOG4106778 Protein of unknown function (DUF1146) DAE22_RS21075 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DAE22_RS21080 ENOG4105JFG SpoIID LytB domain protein DAE22_RS21090 ENOG4108TF4 von Willebrand factor, type A DAE22_RS21100 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DAE22_RS21125 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein DAE22_RS21130 ENOG4105C32 Amino acid ABC transporter (Permease) DAE22_RS21140 ENOG4105C0Z ABC transporter DAE22_RS21145 ENOG4108IV0 ABC, transporter DAE22_RS21150 ENOG4108YZ9 Urea amidohydrolase subunit gamma DAE22_RS21155 ENOG4105KI2 Urea amidohydrolase subunit beta DAE22_RS21160 ENOG4105CQM Urea amidohydrolase subunit alpha DAE22_RS21165 ENOG4108Z40 Transcriptional regulator DAE22_RS21170 ENOG4108RYK Nad-dependent epimerase dehydratase DAE22_RS21175 ENOG4106BRK DAE22_RS21180 ENOG4107TXC Transcriptional regulator DAE22_RS21185 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DAE22_RS21210 ENOG4107TY6 Acylneuraminate cytidylyltransferase DAE22_RS21215 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DAE22_RS21220 ENOG4105C1B dTDP-glucose 4-6-dehydratase DAE22_RS21225 ENOG4105C5E polysaccharide biosynthesis protein DAE22_RS21235 ENOG4107TCE N-acetyltransferase DAE22_RS21240 ENOG4105FRN stage II sporulation protein DAE22_RS21250 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DAE22_RS21260 ENOG4105BZU Histidine kinase DAE22_RS21265 ENOG4107P26 DAE22_RS21270 ENOG4105D3W isochorismatase DAE22_RS21275 ENOG41080V3 Major Facilitator superfamily DAE22_RS21280 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DAE22_RS21285 ENOG4108M26 parallel beta-helix repeat protein DAE22_RS21290 ENOG4105CZM Major Facilitator DAE22_RS21295 ENOG4107MII Sugar-specific transcriptional regulator TrmB DAE22_RS21305 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DAE22_RS21310 ENOG4105DFF Rod shape-determining protein mreb DAE22_RS21320 ENOG4105CGA flagellar basal-body rod protein FlgG DAE22_RS21330 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DAE22_RS21335 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) DAE22_RS21345 ENOG4108VAC response regulator DAE22_RS21355 ENOG4108Z6X (sortase) family DAE22_RS21360 ENOG4108HWY Beta-lactamase DAE22_RS21375 ENOG4105Z8H single-stranded DNA-binding protein DAE22_RS21380 ENOG4105E98 transcriptional regulator DeoR family DAE22_RS21385 ENOG410667J hydrolase