locus-tag	class	description
GSY53_RS00025	COG3223	Belongs to the PsiE family
GSY53_RS00030	COG0642	Histidine kinase
GSY53_RS00030	COG5002	protein histidine kinase activity
GSY53_RS00035	COG0745	RESPONSE REGULATOR receiver
GSY53_RS00040	COG2311	Membrane
GSY53_RS00050	COG0454	-acetyltransferase
GSY53_RS00055	COG2249	NAD(P)H dehydrogenase (quinone) activity
GSY53_RS00065	COG0730	response to heat
GSY53_RS00070	COG0425	Belongs to the sulfur carrier protein TusA family
GSY53_RS00075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSY53_RS00075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GSY53_RS00085	COG0425	Belongs to the sulfur carrier protein TusA family
GSY53_RS00085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GSY53_RS00095	COG2210	Belongs to the sulfur carrier protein TusA family
GSY53_RS00100	COG1937	Protein conserved in bacteria
GSY53_RS00105	COG0662	Cupin 2, conserved barrel domain protein
GSY53_RS00115	COG4978	Transcriptional regulator
GSY53_RS00115	COG0789	Transcriptional regulator
GSY53_RS00120	COG2814	Major facilitator Superfamily
GSY53_RS00125	COG0456	acetyltransferase
GSY53_RS00130	COG1253	flavin adenine dinucleotide binding
GSY53_RS00140	COG0697	spore germination
GSY53_RS00145	COG0583	DNA-binding transcription factor activity
GSY53_RS00150	COG2072	flavoprotein involved in K transport
GSY53_RS00155	COG1230	cation diffusion facilitator family transporter
GSY53_RS00160	COG1942	4-Oxalocrotonate Tautomerase
GSY53_RS00165	COG0583	DNA-binding transcription factor activity
GSY53_RS00175	COG1114	Component of the transport system for branched-chain amino acids
GSY53_RS00180	COG1687	branched-chain amino acid
GSY53_RS00185	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GSY53_RS00190	COG1522	sequence-specific DNA binding
GSY53_RS00195	COG2732	(Barnase) inhibitor
GSY53_RS00200	COG2124	cytochrome p450
GSY53_RS00205	COG1335	isochorismatase
GSY53_RS00220	COG2318	DinB family
GSY53_RS00230	COG2070	2-Nitropropane dioxygenase
GSY53_RS00235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GSY53_RS00255	COG3443	Belongs to the bacterial solute-binding protein 9 family
GSY53_RS00260	COG1595	DNA-templated transcription, initiation
GSY53_RS00265	COG0667	Aldo Keto reductase
GSY53_RS00270	COG2851	Citrate transporter
GSY53_RS00275	COG0583	DNA-binding transcription factor activity
GSY53_RS00280	COG2828	Protein conserved in bacteria
GSY53_RS00285	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS00290	COG5566	PFAM Mor transcription activator
GSY53_RS00295	COG0596	Alpha beta hydrolase
GSY53_RS00300	COG4991	sh3 domain protein
GSY53_RS00305	COG4991	sh3 domain protein
GSY53_RS00315	COG0346	lactoylglutathione lyase activity
GSY53_RS00325	COG5577	PFAM Coat F domain
GSY53_RS00330	COG1063	alcohol dehydrogenase
GSY53_RS00340	COG5577	PFAM Coat F domain
GSY53_RS00345	COG0789	Transcriptional regulator
GSY53_RS00355	COG1064	alcohol dehydrogenase
GSY53_RS00360	COG0693	protein deglycase activity
GSY53_RS00365	COG1621	beta-fructofuranosidase activity
GSY53_RS00370	COG3716	PTS system mannose fructose sorbose family IID component
GSY53_RS00375	COG3715	PTS system
GSY53_RS00380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS00385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY53_RS00390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GSY53_RS00390	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GSY53_RS00400	COG1113	amino acid transport
GSY53_RS00405	COG1280	lysine exporter protein (LysE YggA)
GSY53_RS00410	COG1378	Sugar-specific transcriptional regulator TrmB
GSY53_RS00415	COG1595	DNA-templated transcription, initiation
GSY53_RS00425	COG2755	lipolytic protein G-D-S-L family
GSY53_RS00425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GSY53_RS00435	COG2124	cytochrome p450
GSY53_RS00435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GSY53_RS00440	COG1309	transcriptional regulator
GSY53_RS00445	COG2226	methyltransferase
GSY53_RS00460	COG2116	formate transmembrane transporter activity
GSY53_RS00465	COG5609	conserved protein (DUF2294)
GSY53_RS00470	COG3383	formate dehydrogenase (NAD+) activity
GSY53_RS00475	COG2427	Protein of unknown function (DUF1641)
GSY53_RS00485	COG0626	cystathionine gamma-synthase activity
GSY53_RS00490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GSY53_RS00495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GSY53_RS00500	COG2226	methyltransferase
GSY53_RS00515	COG0768	penicillin binding
GSY53_RS00520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GSY53_RS00525	COG0572	uridine kinase
GSY53_RS00545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GSY53_RS00550	COG3906	Belongs to the UPF0473 family
GSY53_RS00555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GSY53_RS00560	COG4472	Bacterial protein of unknown function (DUF965)
GSY53_RS00565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSY53_RS00570	COG0628	permease
GSY53_RS00575	COG1126	abc transporter atp-binding protein
GSY53_RS00580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY53_RS00585	COG0765	amino acid transport
GSY53_RS00590	COG0765	amino acid transport
GSY53_RS00605	COG3881	PFAM PRC-barrel domain
GSY53_RS00610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GSY53_RS00615	COG0457	Tetratricopeptide repeat
GSY53_RS00620	COG0482	sulfurtransferase activity
GSY53_RS00625	COG1104	cysteine desulfurase activity
GSY53_RS00630	COG1959	2 iron, 2 sulfur cluster binding
GSY53_RS00635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GSY53_RS00640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GSY53_RS00650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GSY53_RS00655	COG0124	histidyl-tRNA synthetase
GSY53_RS00665	COG3103	Sh3 type 3 domain protein
GSY53_RS00665	COG4991	sh3 domain protein
GSY53_RS00665	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS00670	COG1490	D-aminoacyl-tRNA deacylase activity
GSY53_RS00675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GSY53_RS00680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSY53_RS00685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GSY53_RS00685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GSY53_RS00690	COG5416	Lipopolysaccharide assembly protein A domain
GSY53_RS00695	COG0490	domain, Protein
GSY53_RS00700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSY53_RS00700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSY53_RS00710	COG2244	polysaccharide biosynthetic process
GSY53_RS00715	COG2323	membrane
GSY53_RS00725	COG1862	Preprotein translocase
GSY53_RS00730	COG0343	queuine tRNA-ribosyltransferase activity
GSY53_RS00735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GSY53_RS00745	COG2255	four-way junction helicase activity
GSY53_RS00750	COG0632	four-way junction helicase activity
GSY53_RS00760	COG2814	Major facilitator Superfamily
GSY53_RS00765	COG0673	inositol 2-dehydrogenase activity
GSY53_RS00770	COG2112	serine threonine protein kinase
GSY53_RS00790	COG1115	amino acid carrier protein
GSY53_RS00795	COG0217	transcriptional regulatory protein
GSY53_RS00805	COG1388	LysM domain
GSY53_RS00810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GSY53_RS00815	COG0157	Belongs to the NadC ModD family
GSY53_RS00820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GSY53_RS00825	COG1104	cysteine desulfurase activity
GSY53_RS00830	COG1827	regulation of RNA biosynthetic process
GSY53_RS00835	COG0077	Prephenate dehydratase
GSY53_RS00840	COG4492	Belongs to the UPF0735 family
GSY53_RS00845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GSY53_RS00850	COG3290	protein histidine kinase activity
GSY53_RS00860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GSY53_RS00865	COG2868	ribosomal protein
GSY53_RS00870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GSY53_RS00875	COG1994	Peptidase M50
GSY53_RS00880	COG0739	heme binding
GSY53_RS00885	COG2894	cell division
GSY53_RS00890	COG0850	regulation of cytokinetic process
GSY53_RS00895	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GSY53_RS00900	COG1792	Involved in formation and maintenance of cell shape
GSY53_RS00905	COG1077	Cell shape determining protein MreB Mrl
GSY53_RS00910	COG2003	Belongs to the UPF0758 family
GSY53_RS00915	COG0424	maF-like protein
GSY53_RS00925	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GSY53_RS00930	COG0285	dihydrofolate synthase activity
GSY53_RS00935	COG0525	valine-tRNA ligase activity
GSY53_RS00945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GSY53_RS00950	COG1388	LysM domain
GSY53_RS00955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GSY53_RS00960	COG0113	porphobilinogen synthase activity
GSY53_RS00965	COG1587	Uroporphyrinogen-III synthase
GSY53_RS00970	COG0181	hydroxymethylbilane synthase activity
GSY53_RS00975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GSY53_RS00980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GSY53_RS00990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GSY53_RS00995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GSY53_RS01000	COG0470	DNA polymerase III
GSY53_RS01000	COG1067	ATP-dependent peptidase activity
GSY53_RS01005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GSY53_RS01010	COG0544	peptidyl-prolyl cis-trans isomerase activity
GSY53_RS01015	COG1477	protein flavinylation
GSY53_RS01015	COG0457	Tetratricopeptide repeat
GSY53_RS01020	COG0066	3-isopropylmalate dehydratase activity
GSY53_RS01025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GSY53_RS01030	COG0473	3-isopropylmalate dehydrogenase activity
GSY53_RS01035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSY53_RS01040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GSY53_RS01045	COG0440	acetolactate synthase activity
GSY53_RS01050	COG0028	Belongs to the TPP enzyme family
GSY53_RS01060	COG0454	-acetyltransferase
GSY53_RS01065	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GSY53_RS01075	COG0622	Phosphoesterase
GSY53_RS01080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GSY53_RS01085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GSY53_RS01090	COG5401	PFAM Sporulation and spore germination
GSY53_RS01095	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GSY53_RS01100	COG1846	Transcriptional regulator
GSY53_RS01105	COG2197	response regulator
GSY53_RS01110	COG0824	Thioesterase
GSY53_RS01115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GSY53_RS01120	COG1053	succinate dehydrogenase
GSY53_RS01125	COG2009	succinate dehydrogenase
GSY53_RS01130	COG1719	4-vinyl reductase, 4VR
GSY53_RS01135	COG0527	aspartate kinase activity
GSY53_RS01140	COG0322	excinuclease ABC activity
GSY53_RS01145	COG3118	belongs to the thioredoxin family
GSY53_RS01150	COG3534	alpha-L-arabinofuranosidase
GSY53_RS01155	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GSY53_RS01160	COG2086	electron transfer activity
GSY53_RS01165	COG1024	Enoyl-CoA hydratase
GSY53_RS01170	COG1309	transcriptional regulator
GSY53_RS01175	COG0318	PFAM AMP-dependent synthetase and ligase
GSY53_RS01180	COG3766	membrane
GSY53_RS01185	COG1193	negative regulation of DNA recombination
GSY53_RS01190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GSY53_RS01190	COG1796	DNA polymerase
GSY53_RS01195	COG1286	toxin biosynthetic process
GSY53_RS01200	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GSY53_RS01205	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GSY53_RS01210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSY53_RS01210	COG0072	phenylalanine-tRNA ligase activity
GSY53_RS01215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GSY53_RS01225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSY53_RS01235	COG3835	regulator
GSY53_RS01240	COG0277	FAD linked oxidase domain protein
GSY53_RS01245	COG0247	lactate metabolic process
GSY53_RS01250	COG0346	lactoylglutathione lyase activity
GSY53_RS01260	COG1966	Carbon starvation protein
GSY53_RS01265	COG3534	alpha-L-arabinofuranosidase
GSY53_RS01270	COG0395	ABC-type sugar transport system, permease component
GSY53_RS01275	COG1175	transmembrane transport
GSY53_RS01280	COG1653	transport
GSY53_RS01285	COG0371	Dehydrogenase
GSY53_RS01290	COG0647	UMP catabolic process
GSY53_RS01295	COG0235	Class ii aldolase
GSY53_RS01300	COG1069	ribulokinase activity
GSY53_RS01305	COG2160	L-arabinose isomerase activity
GSY53_RS01310	COG3507	Belongs to the glycosyl hydrolase 43 family
GSY53_RS01315	COG1363	Peptidase, m42
GSY53_RS01325	COG3326	Membrane
GSY53_RS01330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GSY53_RS01335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GSY53_RS01340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GSY53_RS01350	COG1346	cytolysis
GSY53_RS01355	COG1380	Effector of murein hydrolase LrgA
GSY53_RS01360	COG3279	Response regulator of the LytR AlgR family
GSY53_RS01365	COG3275	phosphorelay sensor kinase activity
GSY53_RS01375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GSY53_RS01385	COG0398	Pfam SNARE associated Golgi protein
GSY53_RS01390	COG1484	DNA-dependent DNA replication
GSY53_RS01395	COG3611	Membrane attachment protein
GSY53_RS01400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GSY53_RS01405	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GSY53_RS01410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GSY53_RS01415	COG1733	regulation of RNA biosynthetic process
GSY53_RS01420	COG2814	Major facilitator Superfamily
GSY53_RS01425	COG0656	L-ascorbic acid biosynthetic process
GSY53_RS01430	COG0237	dephospho-CoA kinase activity
GSY53_RS01435	COG1971	Probably functions as a manganese efflux pump
GSY53_RS01440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GSY53_RS01445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSY53_RS01445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSY53_RS01450	COG5002	protein histidine kinase activity
GSY53_RS01455	COG0745	RESPONSE REGULATOR receiver
GSY53_RS01460	COG0039	L-malate dehydrogenase activity
GSY53_RS01465	COG0538	isocitrate dehydrogenase activity
GSY53_RS01470	COG0372	Belongs to the citrate synthase family
GSY53_RS01475	COG2707	UPF0756 membrane protein
GSY53_RS01480	COG0628	permease
GSY53_RS01485	COG3030	protein affecting phage T7 exclusion by the F plasmid
GSY53_RS01490	COG0469	pyruvate kinase activity
GSY53_RS01495	COG0205	6-phosphofructokinase activity
GSY53_RS01500	COG0825	malonyl-CoA metabolic process
GSY53_RS01505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GSY53_RS01510	COG0281	malic enzyme
GSY53_RS01515	COG0587	DNA-directed DNA polymerase activity
GSY53_RS01535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GSY53_RS01545	COG4109	DRTGG domain
GSY53_RS01550	COG0730	response to heat
GSY53_RS01555	COG1473	amidohydrolase
GSY53_RS01560	COG0196	riboflavin kinase activity
GSY53_RS01565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY53_RS01570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GSY53_RS01575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY53_RS01580	COG1126	abc transporter atp-binding protein
GSY53_RS01585	COG0765	amino acid transport
GSY53_RS01590	COG0765	amino acid transport
GSY53_RS01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY53_RS01600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY53_RS01605	COG0454	-acetyltransferase
GSY53_RS01610	COG0583	DNA-binding transcription factor activity
GSY53_RS01615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GSY53_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS01630	COG0165	Argininosuccinate lyase
GSY53_RS01635	COG0137	argininosuccinate synthase activity
GSY53_RS01640	COG0521	Mo-molybdopterin cofactor biosynthetic process
GSY53_RS01645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GSY53_RS01655	COG0827	DNA restriction-modification system
GSY53_RS01660	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GSY53_RS01665	COG3874	Sporulation protein YtfJ
GSY53_RS01675	COG1714	RDD family
GSY53_RS01680	COG0616	signal peptide processing
GSY53_RS01685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GSY53_RS01690	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GSY53_RS01695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSY53_RS01705	COG0301	tRNA thio-modification
GSY53_RS01710	COG1104	cysteine desulfurase activity
GSY53_RS01715	COG1114	Component of the transport system for branched-chain amino acids
GSY53_RS01720	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GSY53_RS01725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GSY53_RS01730	COG1309	transcriptional regulator
GSY53_RS01735	COG1956	GAF domain-containing protein
GSY53_RS01740	COG2199	diguanylate cyclase activity
GSY53_RS01740	COG2203	Gaf domain
GSY53_RS01750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GSY53_RS01755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GSY53_RS01760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSY53_RS01765	COG0454	-acetyltransferase
GSY53_RS01770	COG0517	IMP dehydrogenase activity
GSY53_RS01775	COG0123	including yeast histone deacetylase and acetoin utilization protein
GSY53_RS01780	COG1360	Flagellar Motor Protein
GSY53_RS01785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GSY53_RS01790	COG1609	Transcriptional regulator
GSY53_RS01795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GSY53_RS01795	COG1605	Chorismate mutase
GSY53_RS01800	COG3118	belongs to the thioredoxin family
GSY53_RS01805	COG4980	gas vesicle protein
GSY53_RS01810	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GSY53_RS01815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GSY53_RS01820	COG1674	ftsk spoiiie
GSY53_RS01825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSY53_RS01830	COG4848	Belongs to the UPF0354 family
GSY53_RS01835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS01850	COG1363	Peptidase, m42
GSY53_RS01855	COG5584	Small secreted protein
GSY53_RS01860	COG0281	malic enzyme
GSY53_RS01865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSY53_RS01870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GSY53_RS01880	COG0510	thiamine kinase activity
GSY53_RS01885	COG1523	belongs to the glycosyl hydrolase 13 family
GSY53_RS01890	COG1597	lipid kinase activity
GSY53_RS01900	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GSY53_RS01905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GSY53_RS01910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSY53_RS01915	COG2252	PERMEase
GSY53_RS01920	COG4473	ABC transporter
GSY53_RS01925	COG1131	(ABC) transporter
GSY53_RS01930	COG1349	DNA-binding transcription factor activity
GSY53_RS01935	COG1187	pseudouridine synthase activity
GSY53_RS01940	COG2244	polysaccharide biosynthetic process
GSY53_RS01945	COG2081	HI0933 family
GSY53_RS01950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GSY53_RS01960	COG5578	integral membrane protein
GSY53_RS01965	COG0673	inositol 2-dehydrogenase activity
GSY53_RS01970	COG1653	transport
GSY53_RS01975	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GSY53_RS01980	COG4209	transmembrane transport
GSY53_RS01985	COG2207	Transcriptional regulator
GSY53_RS01990	COG1653	transport
GSY53_RS01995	COG0395	ABC-type sugar transport system, permease component
GSY53_RS02000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSY53_RS02005	COG2124	cytochrome p450
GSY53_RS02010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GSY53_RS02020	COG0156	8-amino-7-oxononanoate synthase activity
GSY53_RS02025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GSY53_RS02035	COG1073	alpha beta
GSY53_RS02060	COG1486	melibiose metabolic process
GSY53_RS02065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GSY53_RS02070	COG0495	leucyl-tRNA aminoacylation
GSY53_RS02080	COG2202	Pas domain
GSY53_RS02080	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY53_RS02085	COG2814	Major facilitator Superfamily
GSY53_RS02090	COG2433	Pfam Transposase IS66
GSY53_RS02095	COG0577	efflux transmembrane transporter activity
GSY53_RS02100	COG1136	(ABC) transporter
GSY53_RS02105	COG2205	protein histidine kinase activity
GSY53_RS02110	COG0745	RESPONSE REGULATOR receiver
GSY53_RS02115	COG0577	efflux transmembrane transporter activity
GSY53_RS02120	COG1136	(ABC) transporter
GSY53_RS02135	COG1131	(ABC) transporter
GSY53_RS02140	COG1725	Transcriptional regulator
GSY53_RS02155	COG1242	4 iron, 4 sulfur cluster binding
GSY53_RS02160	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GSY53_RS02170	COG2267	carboxylic ester hydrolase activity
GSY53_RS02175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GSY53_RS02180	COG1113	amino acid transport
GSY53_RS02185	COG0367	asparagine synthase
GSY53_RS02190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GSY53_RS02195	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GSY53_RS02205	COG1506	peptidase
GSY53_RS02210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GSY53_RS02215	COG1116	anion transmembrane transporter activity
GSY53_RS02220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSY53_RS02225	COG0494	nUDIX hydrolase
GSY53_RS02230	COG4824	toxin secretion phage lysis holin
GSY53_RS02235	COG0783	Belongs to the Dps family
GSY53_RS02250	COG1854	S-ribosylhomocysteine lyase activity
GSY53_RS02255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GSY53_RS02260	COG0288	reversible hydration of carbon dioxide
GSY53_RS02265	COG0254	rRNA binding
GSY53_RS02270	COG1271	oxidase subunit
GSY53_RS02275	COG1294	oxidase, subunit
GSY53_RS02285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSY53_RS02290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSY53_RS02290	COG1321	iron dependent repressor
GSY53_RS02295	COG1121	(ABC) transporter
GSY53_RS02300	COG0803	Belongs to the bacterial solute-binding protein 9 family
GSY53_RS02305	COG4948	Mandelate Racemase Muconate Lactonizing
GSY53_RS02310	COG0318	PFAM AMP-dependent synthetase and ligase
GSY53_RS02315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GSY53_RS02320	COG0596	Alpha beta hydrolase
GSY53_RS02325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GSY53_RS02330	COG1169	isochorismate synthase
GSY53_RS02335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GSY53_RS02340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSY53_RS02345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GSY53_RS02350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSY53_RS02355	COG0438	transferase activity, transferring glycosyl groups
GSY53_RS02365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GSY53_RS02370	COG0438	transferase activity, transferring glycosyl groups
GSY53_RS02375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GSY53_RS02380	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GSY53_RS02385	COG0058	SHG alpha-glucan phosphorylase activity
GSY53_RS02390	COG0297	glycogen (starch) synthase activity
GSY53_RS02395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GSY53_RS02400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GSY53_RS02405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GSY53_RS02530	COG3859	Proton-coupled thiamine transporter YuaJ
GSY53_RS02535	COG1247	-acetyltransferase
GSY53_RS02540	COG2268	Band 7 protein
GSY53_RS02545	COG1585	Membrane protein implicated in regulation of membrane protease activity
GSY53_RS02550	COG2318	DinB family
GSY53_RS02560	COG1454	alcohol dehydrogenase
GSY53_RS02570	COG1510	regulation of RNA biosynthetic process
GSY53_RS02580	COG0569	domain protein
GSY53_RS02585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GSY53_RS02590	COG4682	membrane
GSY53_RS02595	COG1705	Flagellar rod assembly protein muramidase FlgJ
GSY53_RS02600	COG0477	Major facilitator Superfamily
GSY53_RS02605	COG5553	Cysteine dioxygenase type I
GSY53_RS02615	COG1968	undecaprenyl-diphosphatase activity
GSY53_RS02620	COG0628	permease
GSY53_RS02625	COG0673	inositol 2-dehydrogenase activity
GSY53_RS02630	COG4806	L-rhamnose isomerase
GSY53_RS02635	COG3254	rhamnose metabolic process
GSY53_RS02640	COG1070	Carbohydrate kinase
GSY53_RS02645	COG1349	DNA-binding transcription factor activity
GSY53_RS02650	COG3347	Dehydrogenase
GSY53_RS02650	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS02655	COG0840	transmembrane signaling receptor activity
GSY53_RS02660	COG0840	transmembrane signaling receptor activity
GSY53_RS02665	COG0840	transmembrane signaling receptor activity
GSY53_RS02670	COG0840	transmembrane signaling receptor activity
GSY53_RS02685	COG0432	Pfam Uncharacterised protein family UPF0047
GSY53_RS02695	COG0366	Alpha amylase catalytic
GSY53_RS02700	COG1253	flavin adenine dinucleotide binding
GSY53_RS02705	COG2738	Putative neutral zinc metallopeptidase
GSY53_RS02720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GSY53_RS02735	COG0166	Belongs to the GPI family
GSY53_RS02740	COG1979	alcohol dehydrogenase
GSY53_RS02745	COG1979	alcohol dehydrogenase
GSY53_RS02750	COG2155	Conserved Protein
GSY53_RS02755	COG1098	S1 RNA binding domain
GSY53_RS02760	COG0436	Aminotransferase
GSY53_RS02765	COG1522	sequence-specific DNA binding
GSY53_RS02770	COG2267	carboxylic ester hydrolase activity
GSY53_RS02780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GSY53_RS02785	COG2205	protein histidine kinase activity
GSY53_RS02795	COG5018	Exonuclease
GSY53_RS02805	COG2814	Major facilitator Superfamily
GSY53_RS02810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSY53_RS02815	COG3011	Protein conserved in bacteria
GSY53_RS02825	COG3290	protein histidine kinase activity
GSY53_RS02830	COG4565	transcriptional regulatory protein
GSY53_RS02855	COG3493	citrate carrier protein
GSY53_RS02865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GSY53_RS02865	COG2111	Na H antiporter
GSY53_RS02870	COG2111	Na H antiporter
GSY53_RS02875	COG1006	Multisubunit Na H antiporter MnhC subunit
GSY53_RS02880	COG0651	ATP synthesis coupled electron transport
GSY53_RS02885	COG1863	multisubunit Na H antiporter MnhE subunit
GSY53_RS02890	COG2212	antiporter activity
GSY53_RS02895	COG1320	monovalent cation:proton antiporter activity
GSY53_RS02900	COG2050	protein possibly involved in aromatic compounds catabolism
GSY53_RS02905	COG2197	response regulator
GSY53_RS02910	COG4585	Histidine kinase
GSY53_RS02920	COG0142	geranyltranstransferase activity
GSY53_RS02940	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GSY53_RS02945	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GSY53_RS02950	COG1335	isochorismatase
GSY53_RS02955	COG5506	Protein of unknown function (DUF1694)
GSY53_RS02970	COG0628	permease
GSY53_RS02985	COG1418	mRNA catabolic process
GSY53_RS02990	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS03000	COG1511	domain protein
GSY53_RS03005	COG1674	ftsk spoiiie
GSY53_RS03005	COG0433	COG0433 Predicted ATPase
GSY53_RS03010	COG4499	WXG100 protein secretion system (Wss), protein YukC
GSY53_RS03015	COG5417	Belongs to the EsaB family
GSY53_RS03020	COG4842	Belongs to the WXG100 family
GSY53_RS03025	COG2508	Transcriptional regulator
GSY53_RS03025	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GSY53_RS03030	COG0686	Belongs to the AlaDH PNT family
GSY53_RS03035	COG5634	Uncharacterized conserved protein (DUF2278)
GSY53_RS03040	COG3251	PFAM MbtH domain protein
GSY53_RS03045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS03050	COG1535	isochorismatase
GSY53_RS03050	COG3433	isochorismatase activity
GSY53_RS03055	COG1021	2,3-dihydroxybenzoate-AMP ligase
GSY53_RS03060	COG1169	isochorismate synthase
GSY53_RS03065	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS03070	COG2819	hydrolase of the alpha beta superfamily
GSY53_RS03075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GSY53_RS03080	COG1268	BioY protein
GSY53_RS03085	COG2056	Na+-H+ antiporter family
GSY53_RS03090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GSY53_RS03095	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GSY53_RS03100	COG3584	3D domain protein
GSY53_RS03115	COG1252	NADH dehydrogenase
GSY53_RS03120	COG0492	ferredoxin-NADP+ reductase activity
GSY53_RS03130	COG0516	GMP reductase activity
GSY53_RS03135	COG2808	Putative FMN-binding domain
GSY53_RS03140	COG0456	acetyltransferase
GSY53_RS03145	COG0316	Belongs to the HesB IscA family
GSY53_RS03150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GSY53_RS03155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GSY53_RS03160	COG4844	belongs to the
GSY53_RS03165	COG1252	NADH dehydrogenase
GSY53_RS03170	COG4837	Protein of unknown function (DUF1462)
GSY53_RS03175	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GSY53_RS03180	COG4946	Tricorn protease homolog
GSY53_RS03180	COG1506	peptidase
GSY53_RS03180	COG0823	Involved in the tonB-independent uptake of proteins
GSY53_RS03185	COG0083	homoserine kinase activity
GSY53_RS03190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GSY53_RS03195	COG0460	homoserine dehydrogenase
GSY53_RS03200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GSY53_RS03205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GSY53_RS03210	COG0647	UMP catabolic process
GSY53_RS03215	COG2445	Protein of unknown function DUF86
GSY53_RS03220	COG4470	Protein conserved in bacteria
GSY53_RS03230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GSY53_RS03235	COG0739	heme binding
GSY53_RS03245	COG3377	Domain of unknown function (DUF1805)
GSY53_RS03250	COG0737	Belongs to the 5'-nucleotidase family
GSY53_RS03255	COG0730	response to heat
GSY53_RS03260	COG1801	Protein of unknown function DUF72
GSY53_RS03270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GSY53_RS03275	COG2508	Transcriptional regulator
GSY53_RS03280	COG2233	PERMEase
GSY53_RS03285	COG2233	PERMEase
GSY53_RS03290	COG3648	Uricase
GSY53_RS03290	COG3195	allantoin biosynthetic process
GSY53_RS03295	COG2351	hydroxyisourate hydrolase activity
GSY53_RS03305	COG2080	2 iron, 2 sulfur cluster binding
GSY53_RS03310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GSY53_RS03315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GSY53_RS03320	COG2068	MobA-Related Protein
GSY53_RS03325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GSY53_RS03330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GSY53_RS03335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSY53_RS03345	COG2356	endonuclease I
GSY53_RS03350	COG3842	ATPase activity
GSY53_RS03355	COG2188	Transcriptional regulator
GSY53_RS03360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY53_RS03365	COG0395	ABC-type sugar transport system, permease component
GSY53_RS03370	COG1175	transmembrane transport
GSY53_RS03375	COG1653	transport
GSY53_RS03380	COG2222	sugar isomerase
GSY53_RS03385	COG0322	excinuclease ABC activity
GSY53_RS03390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSY53_RS03405	COG0346	lactoylglutathione lyase activity
GSY53_RS03410	COG0640	Transcriptional regulator
GSY53_RS03415	COG0719	Fe-S assembly protein
GSY53_RS03420	COG0822	iron-sulfur transferase activity
GSY53_RS03425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSY53_RS03430	COG0719	Fe-S assembly protein
GSY53_RS03435	COG0396	ATPase activity
GSY53_RS03445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSY53_RS03450	COG1464	Belongs to the NlpA lipoprotein family
GSY53_RS03455	COG2011	ABC-type metal ion transport system permease component
GSY53_RS03460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GSY53_RS03470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS03475	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GSY53_RS03485	COG0509	glycine decarboxylation via glycine cleavage system
GSY53_RS03490	COG1393	Belongs to the ArsC family
GSY53_RS03495	COG1960	acyl-CoA dehydrogenase activity
GSY53_RS03500	COG0183	Belongs to the thiolase family
GSY53_RS03505	COG1024	Enoyl-CoA hydratase
GSY53_RS03505	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSY53_RS03515	COG0506	proline dehydrogenase activity
GSY53_RS03525	COG5577	PFAM Coat F domain
GSY53_RS03530	COG1846	Transcriptional regulator
GSY53_RS03535	COG0477	Major facilitator Superfamily
GSY53_RS03540	COG1942	4-Oxalocrotonate Tautomerase
GSY53_RS03550	COG0583	DNA-binding transcription factor activity
GSY53_RS03560	COG1120	ATPase activity
GSY53_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS03580	COG0783	Belongs to the Dps family
GSY53_RS03585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSY53_RS03590	COG0745	RESPONSE REGULATOR receiver
GSY53_RS03595	COG2205	protein histidine kinase activity
GSY53_RS03595	COG2770	Histidine kinase
GSY53_RS03605	COG1309	transcriptional regulator
GSY53_RS03610	COG0114	fumarate hydratase activity
GSY53_RS03620	COG0697	spore germination
GSY53_RS03625	COG0814	amino acid
GSY53_RS03635	COG2197	response regulator
GSY53_RS03640	COG4585	Histidine kinase
GSY53_RS03645	COG4758	membrane
GSY53_RS03650	COG3595	metallopeptidase activity
GSY53_RS03655	COG1842	Phage shock protein A
GSY53_RS03660	COG4758	membrane
GSY53_RS03665	COG2814	Major facilitator Superfamily
GSY53_RS03670	COG2096	Adenosyltransferase
GSY53_RS03675	COG1120	ATPase activity
GSY53_RS03680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS03685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSY53_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS03695	COG3386	PFAM SMP-30 Gluconolaconase
GSY53_RS03700	COG2205	protein histidine kinase activity
GSY53_RS03705	COG0745	RESPONSE REGULATOR receiver
GSY53_RS03715	COG1191	sigma factor activity
GSY53_RS03725	COG2140	Oxalate decarboxylase
GSY53_RS03735	COG0577	efflux transmembrane transporter activity
GSY53_RS03740	COG1136	(ABC) transporter
GSY53_RS03745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSY53_RS03750	COG1120	ATPase activity
GSY53_RS03755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS03760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS03765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSY53_RS03770	COG0531	amino acid
GSY53_RS03780	COG1988	membrane-bound metal-dependent
GSY53_RS03785	COG1368	sulfuric ester hydrolase activity
GSY53_RS03790	COG1910	domain protein
GSY53_RS03795	COG0725	ABC transporter, periplasmic molybdate-binding protein
GSY53_RS03800	COG4149	molybdate abc transporter
GSY53_RS03805	COG0656	L-ascorbic acid biosynthetic process
GSY53_RS03815	COG0025	NhaP-type Na H and K H
GSY53_RS03820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSY53_RS03825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GSY53_RS03830	COG3973	AAA domain
GSY53_RS03835	COG2860	membrane
GSY53_RS03840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GSY53_RS03845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GSY53_RS03850	COG2217	Heavy metal translocating P-type atpase
GSY53_RS03855	COG2217	Heavy metal translocating P-type atpase
GSY53_RS03860	COG2608	mercury ion transmembrane transporter activity
GSY53_RS03865	COG1937	Protein conserved in bacteria
GSY53_RS03870	COG0673	inositol 2-dehydrogenase activity
GSY53_RS03875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GSY53_RS03880	COG1289	transmembrane transporter activity
GSY53_RS03890	COG2076	Multidrug Resistance protein
GSY53_RS03895	COG1309	transcriptional regulator
GSY53_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS03910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GSY53_RS03915	COG0557	exoribonuclease II activity
GSY53_RS03920	COG1647	Serine aminopeptidase, S33
GSY53_RS03925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSY53_RS03930	COG0596	Alpha beta hydrolase
GSY53_RS03935	COG1476	TRANSCRIPTIONal
GSY53_RS03940	COG1396	sequence-specific DNA binding
GSY53_RS03945	COG1396	sequence-specific DNA binding
GSY53_RS03950	COG1733	regulation of RNA biosynthetic process
GSY53_RS03955	COG0840	transmembrane signaling receptor activity
GSY53_RS03960	COG1174	glycine betaine transport
GSY53_RS03965	COG1732	Glycine betaine
GSY53_RS03970	COG1174	glycine betaine transport
GSY53_RS03975	COG1125	glycine betaine transport
GSY53_RS03975	COG0517	IMP dehydrogenase activity
GSY53_RS03980	COG1510	regulation of RNA biosynthetic process
GSY53_RS04000	COG5658	integral membrane protein
GSY53_RS04005	COG0640	Transcriptional regulator
GSY53_RS04010	COG1174	glycine betaine transport
GSY53_RS04015	COG1732	Glycine betaine
GSY53_RS04020	COG1174	glycine betaine transport
GSY53_RS04025	COG0517	IMP dehydrogenase activity
GSY53_RS04025	COG1125	glycine betaine transport
GSY53_RS04030	COG1510	regulation of RNA biosynthetic process
GSY53_RS04035	COG2095	MarC family integral membrane protein
GSY53_RS04045	COG3064	Membrane
GSY53_RS04050	COG4640	response to antibiotic
GSY53_RS04055	COG0456	acetyltransferase
GSY53_RS04060	COG0148	phosphopyruvate hydratase activity
GSY53_RS04065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GSY53_RS04070	COG0149	triose-phosphate isomerase activity
GSY53_RS04075	COG0126	phosphoglycerate kinase activity
GSY53_RS04080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GSY53_RS04085	COG2390	Transcriptional regulator
GSY53_RS04090	COG2814	Major facilitator Superfamily
GSY53_RS04095	COG1609	Transcriptional regulator
GSY53_RS04100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY53_RS04105	COG0583	DNA-binding transcription factor activity
GSY53_RS04110	COG0697	spore germination
GSY53_RS04115	COG1113	amino acid transport
GSY53_RS04120	COG3858	chitin binding
GSY53_RS04125	COG1556	Lactate utilization protein
GSY53_RS04130	COG1139	Iron-sulfur cluster binding protein
GSY53_RS04135	COG0247	lactate metabolic process
GSY53_RS04140	COG2197	response regulator
GSY53_RS04145	COG4585	Histidine kinase
GSY53_RS04150	COG0842	Transport permease protein
GSY53_RS04155	COG1131	(ABC) transporter
GSY53_RS04160	COG0596	Alpha beta hydrolase
GSY53_RS04165	COG2208	phosphoserine phosphatase activity
GSY53_RS04170	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GSY53_RS04175	COG1874	Beta-galactosidase
GSY53_RS04180	COG3833	ABC-type maltose transport systems, permease component
GSY53_RS04185	COG1175	transmembrane transport
GSY53_RS04190	COG2182	Extracellular solute-binding protein
GSY53_RS04195	COG1609	Transcriptional regulator
GSY53_RS04200	COG2186	Transcriptional regulator
GSY53_RS04205	COG1620	l-lactate permease
GSY53_RS04210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GSY53_RS04220	COG5039	Polysaccharide pyruvyl transferase
GSY53_RS04225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GSY53_RS04230	COG0110	maltose O-acetyltransferase activity
GSY53_RS04235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GSY53_RS04240	COG2244	polysaccharide biosynthetic process
GSY53_RS04245	COG1216	Glycosyl transferase, family 2
GSY53_RS04250	COG5039	Polysaccharide pyruvyl transferase
GSY53_RS04255	COG1216	Glycosyl transferase, family 2
GSY53_RS04265	COG0438	transferase activity, transferring glycosyl groups
GSY53_RS04270	COG1215	transferase activity, transferring glycosyl groups
GSY53_RS04275	COG0438	transferase activity, transferring glycosyl groups
GSY53_RS04280	COG1086	Polysaccharide biosynthesis protein
GSY53_RS04285	COG0489	protein tyrosine kinase activity
GSY53_RS04290	COG3944	biosynthesis protein
GSY53_RS04295	COG1396	sequence-specific DNA binding
GSY53_RS04300	COG2272	Belongs to the type-B carboxylesterase lipase family
GSY53_RS04310	COG3479	Phenolic acid decarboxylase
GSY53_RS04320	COG1794	racemase activity, acting on amino acids and derivatives
GSY53_RS04325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GSY53_RS04330	COG1621	beta-fructofuranosidase activity
GSY53_RS04335	COG1621	beta-fructofuranosidase activity
GSY53_RS04340	COG0531	amino acid
GSY53_RS04345	COG1309	transcriptional regulator
GSY53_RS04350	COG2076	Multidrug Resistance protein
GSY53_RS04355	COG2076	Multidrug Resistance protein
GSY53_RS04365	COG0277	FAD linked oxidase domain protein
GSY53_RS04370	COG3621	Patatin-like phospholipase
GSY53_RS04380	COG0740	serine-type endopeptidase activity
GSY53_RS04385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSY53_RS04390	COG0366	Alpha amylase catalytic
GSY53_RS04395	COG1554	hydrolase, family 65, central catalytic
GSY53_RS04400	COG5521	maltodextrose utilization protein MalA
GSY53_RS04405	COG3833	ABC-type maltose transport systems, permease component
GSY53_RS04410	COG1175	transmembrane transport
GSY53_RS04415	COG2182	Extracellular solute-binding protein
GSY53_RS04420	COG0366	Alpha amylase catalytic
GSY53_RS04425	COG1609	Transcriptional regulator
GSY53_RS04430	COG1611	Belongs to the LOG family
GSY53_RS04435	COG1694	Mazg nucleotide pyrophosphohydrolase
GSY53_RS04440	COG0659	secondary active sulfate transmembrane transporter activity
GSY53_RS04445	COG0288	reversible hydration of carbon dioxide
GSY53_RS04450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSY53_RS04455	COG0577	efflux transmembrane transporter activity
GSY53_RS04460	COG1136	(ABC) transporter
GSY53_RS04465	COG5002	protein histidine kinase activity
GSY53_RS04470	COG0745	RESPONSE REGULATOR receiver
GSY53_RS04480	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GSY53_RS04485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY53_RS04490	COG1481	regulation of sporulation
GSY53_RS04495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GSY53_RS04500	COG1660	Displays ATPase and GTPase activities
GSY53_RS04505	COG1051	belongs to the nudix hydrolase family
GSY53_RS04510	COG0492	ferredoxin-NADP+ reductase activity
GSY53_RS04515	COG3883	PFAM NLP P60 protein
GSY53_RS04515	COG0791	NLP P60 protein
GSY53_RS04520	COG0457	Tetratricopeptide repeat
GSY53_RS04525	COG1132	(ABC) transporter
GSY53_RS04545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GSY53_RS04545	COG0140	phosphoribosyl-ATP diphosphatase activity
GSY53_RS04550	COG0107	imidazoleglycerol-phosphate synthase activity
GSY53_RS04555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GSY53_RS04560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GSY53_RS04565	COG0131	Imidazoleglycerol-phosphate dehydratase
GSY53_RS04570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GSY53_RS04575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GSY53_RS04580	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GSY53_RS04585	COG4990	cell redox homeostasis
GSY53_RS04590	COG5297	Belongs to the glycosyl hydrolase family 6
GSY53_RS04595	COG0110	maltose O-acetyltransferase activity
GSY53_RS04600	COG0546	phosphoglycolate phosphatase activity
GSY53_RS04605	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GSY53_RS04610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GSY53_RS04615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GSY53_RS04620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GSY53_RS04625	COG0363	glucosamine-6-phosphate deaminase activity
GSY53_RS04635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GSY53_RS04640	COG1846	Transcriptional regulator
GSY53_RS04645	COG2124	cytochrome p450
GSY53_RS04655	COG1846	Transcriptional regulator
GSY53_RS04660	COG2814	Major facilitator Superfamily
GSY53_RS04665	COG1950	PFAM Membrane protein of
GSY53_RS04670	COG1983	PspC domain protein
GSY53_RS04675	COG3595	metallopeptidase activity
GSY53_RS04695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GSY53_RS04700	COG0556	nucleotide-excision repair
GSY53_RS04705	COG4897	Protein conserved in bacteria
GSY53_RS04710	COG0574	Belongs to the PEP-utilizing enzyme family
GSY53_RS04710	COG3848	Pyruvate phosphate dikinase
GSY53_RS04715	COG1309	transcriptional regulator
GSY53_RS04720	COG2814	Major facilitator Superfamily
GSY53_RS04725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSY53_RS04735	COG0793	Belongs to the peptidase S41A family
GSY53_RS04735	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS04740	COG2177	Part of the ABC transporter FtsEX involved in
GSY53_RS04745	COG2884	Cell division ATP-binding protein ftsE
GSY53_RS04750	COG2010	Cytochrome c
GSY53_RS04755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSY53_RS04765	COG0653	protein targeting
GSY53_RS04770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GSY53_RS04785	COG1516	flagellar protein fliS
GSY53_RS04790	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GSY53_RS04795	COG1334	flagellar protein FlaG
GSY53_RS04800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GSY53_RS04805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GSY53_RS04810	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GSY53_RS04820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GSY53_RS04825	COG1256	bacterial-type flagellum assembly
GSY53_RS04825	COG4786	Flagellar basal body rod
GSY53_RS04830	COG3418	PFAM FlgN family protein
GSY53_RS04835	COG2747	anti-sigma28 factor FlgM
GSY53_RS04845	COG1040	competence protein
GSY53_RS04855	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GSY53_RS04860	COG1307	EDD domain protein, DegV family
GSY53_RS04865	COG2197	response regulator
GSY53_RS04870	COG4585	Histidine kinase
GSY53_RS04875	COG1739	Uncharacterized protein family UPF0029
GSY53_RS04880	COG1316	TRANSCRIPTIONal
GSY53_RS04885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSY53_RS04890	COG0438	transferase activity, transferring glycosyl groups
GSY53_RS04895	COG1215	transferase activity, transferring glycosyl groups
GSY53_RS04900	COG3206	protein involved in exopolysaccharide biosynthesis
GSY53_RS04905	COG3307	-O-antigen
GSY53_RS04910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GSY53_RS04915	COG0297	glycogen (starch) synthase activity
GSY53_RS04915	COG0438	transferase activity, transferring glycosyl groups
GSY53_RS04920	COG2244	polysaccharide biosynthetic process
GSY53_RS04930	COG2247	cell wall binding repeat
GSY53_RS04930	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS04935	COG2247	cell wall binding repeat
GSY53_RS04935	COG2385	sporulation resulting in formation of a cellular spore
GSY53_RS04945	COG1316	TRANSCRIPTIONal
GSY53_RS04950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GSY53_RS04955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSY53_RS04965	COG1215	transferase activity, transferring glycosyl groups
GSY53_RS04965	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSY53_RS04970	COG0463	Glycosyl transferase, family 2
GSY53_RS04980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSY53_RS04990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSY53_RS04995	COG1134	teichoic acid transport
GSY53_RS05000	COG1682	transport, permease protein
GSY53_RS05005	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSY53_RS05010	COG0438	transferase activity, transferring glycosyl groups
GSY53_RS05015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GSY53_RS05020	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GSY53_RS05025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSY53_RS05035	COG4193	domain, Protein
GSY53_RS05040	COG1482	cell wall glycoprotein biosynthetic process
GSY53_RS05045	COG0697	spore germination
GSY53_RS05050	COG0814	amino acid
GSY53_RS05060	COG2814	Major facilitator Superfamily
GSY53_RS05065	COG1316	TRANSCRIPTIONal
GSY53_RS05070	COG0561	phosphatase activity
GSY53_RS05075	COG0791	NLP P60 protein
GSY53_RS05085	COG2843	Capsule synthesis protein
GSY53_RS05095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GSY53_RS05100	COG1609	Transcriptional regulator
GSY53_RS05105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY53_RS05110	COG1869	D-ribose catabolic process
GSY53_RS05115	COG1129	ABC transporter
GSY53_RS05120	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSY53_RS05125	COG1879	ABC-type sugar transport system periplasmic component
GSY53_RS05130	COG3103	Sh3 type 3 domain protein
GSY53_RS05140	COG2249	NAD(P)H dehydrogenase (quinone) activity
GSY53_RS05145	COG3527	Alpha-acetolactate decarboxylase
GSY53_RS05150	COG0028	Belongs to the TPP enzyme family
GSY53_RS05155	COG0583	DNA-binding transcription factor activity
GSY53_RS05160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GSY53_RS05175	COG5337	Spore coat protein CotH
GSY53_RS05185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GSY53_RS05195	COG0405	Gamma-glutamyltransferase
GSY53_RS05200	COG1522	sequence-specific DNA binding
GSY53_RS05205	COG2059	Chromate
GSY53_RS05210	COG2059	Chromate
GSY53_RS05220	COG0655	NAD(P)H dehydrogenase (quinone) activity
GSY53_RS05225	COG0583	DNA-binding transcription factor activity
GSY53_RS05240	COG5444	nuclease activity
GSY53_RS05260	COG3878	Protein conserved in bacteria
GSY53_RS05265	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GSY53_RS05270	COG4464	protein tyrosine phosphatase activity
GSY53_RS05275	COG0489	protein tyrosine kinase activity
GSY53_RS05280	COG3944	biosynthesis protein
GSY53_RS05290	COG4715	Zinc finger, swim domain protein
GSY53_RS05295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GSY53_RS05300	COG0561	phosphatase activity
GSY53_RS05305	COG1349	DNA-binding transcription factor activity
GSY53_RS05310	COG0629	single-stranded DNA binding
GSY53_RS05325	COG3764	Sortase (surface protein transpeptidase)
GSY53_RS05335	COG2972	Histidine kinase
GSY53_RS05335	COG0745	RESPONSE REGULATOR receiver
GSY53_RS05340	COG1970	mechanosensitive ion channel activity
GSY53_RS05345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GSY53_RS05350	COG0457	Tetratricopeptide repeat
GSY53_RS05355	COG4786	Flagellar basal body rod
GSY53_RS05360	COG4786	Flagellar basal body rod
GSY53_RS05365	COG1077	Cell shape determining protein MreB Mrl
GSY53_RS05370	COG1609	Transcriptional regulator
GSY53_RS05380	COG1846	Transcriptional regulator
GSY53_RS05385	COG2814	Major facilitator Superfamily
GSY53_RS05390	COG3420	alginic acid biosynthetic process
GSY53_RS05395	COG1953	Uracil, thiamine, allantoin
GSY53_RS05400	COG0477	Major facilitator Superfamily
GSY53_RS05405	COG1335	isochorismatase
GSY53_RS05415	COG0004	ammonium transporteR
GSY53_RS05420	COG0347	Belongs to the P(II) protein family
GSY53_RS05425	COG0671	phosphoesterase, PA-phosphatase related
GSY53_RS05435	COG0739	heme binding
GSY53_RS05440	COG1247	-acetyltransferase
GSY53_RS05460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GSY53_RS05465	COG0789	Transcriptional regulator
GSY53_RS05475	COG2910	NAD(P)H-binding
GSY53_RS05480	COG1959	2 iron, 2 sulfur cluster binding
GSY53_RS05485	COG0804	urea catabolic process
GSY53_RS05490	COG0832	Belongs to the urease beta subunit family
GSY53_RS05495	COG0831	urea catabolic process
GSY53_RS05510	COG3237	CsbD-like
GSY53_RS05515	COG1994	Peptidase M50
GSY53_RS05520	COG0457	Tetratricopeptide repeat
GSY53_RS05525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GSY53_RS05530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GSY53_RS05540	COG2304	oxidoreductase activity
GSY53_RS05550	COG2304	oxidoreductase activity
GSY53_RS05555	COG2385	sporulation resulting in formation of a cellular spore
GSY53_RS05560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSY53_RS05570	COG4836	Membrane
GSY53_RS05580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GSY53_RS05585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GSY53_RS05590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GSY53_RS05595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GSY53_RS05600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GSY53_RS05605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GSY53_RS05610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GSY53_RS05615	COG0356	it plays a direct role in the translocation of protons across the membrane
GSY53_RS05625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GSY53_RS05630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GSY53_RS05635	COG4475	Protein of unknown function (DUF436)
GSY53_RS05640	COG0698	ribose 5-phosphate isomerase
GSY53_RS05645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSY53_RS05650	COG1971	Probably functions as a manganese efflux pump
GSY53_RS05655	COG0009	L-threonylcarbamoyladenylate synthase
GSY53_RS05660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GSY53_RS05680	COG2890	protein-(glutamine-N5) methyltransferase activity
GSY53_RS05685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GSY53_RS05690	COG0346	lactoylglutathione lyase activity
GSY53_RS05695	COG0789	Transcriptional regulator
GSY53_RS05700	COG0679	Auxin Efflux Carrier
GSY53_RS05705	COG0281	malic enzyme
GSY53_RS05710	COG1435	thymidine kinase activity
GSY53_RS05715	COG0254	rRNA binding
GSY53_RS05720	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GSY53_RS05730	COG1494	fructose-1,6-bisphosphatase
GSY53_RS05735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSY53_RS05740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GSY53_RS05745	COG0191	fructose-bisphosphate aldolase activity
GSY53_RS05750	COG2204	response regulator
GSY53_RS05755	COG4821	SIS domain
GSY53_RS05760	COG0504	CTP synthase activity
GSY53_RS05765	COG3343	RNA polymerase activity
GSY53_RS05770	COG1960	acyl-CoA dehydrogenase activity
GSY53_RS05775	COG2181	nitrate reductase activity
GSY53_RS05775	COG0247	lactate metabolic process
GSY53_RS05780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GSY53_RS05785	COG4294	response to UV
GSY53_RS05795	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GSY53_RS05800	COG1132	(ABC) transporter
GSY53_RS05805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GSY53_RS05815	COG2181	nitrate reductase activity
GSY53_RS05820	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GSY53_RS05825	COG1140	nitrate reductase beta subunit
GSY53_RS05830	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GSY53_RS05835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSY53_RS05845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSY53_RS05850	COG2223	nitrite transmembrane transporter activity
GSY53_RS05855	COG0018	arginyl-trna synthetase
GSY53_RS05860	COG4506	Protein conserved in bacteria
GSY53_RS05875	COG0535	radical SAM domain protein
GSY53_RS05885	COG1131	(ABC) transporter
GSY53_RS05890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GSY53_RS05895	COG0612	Peptidase, M16
GSY53_RS05900	COG0612	Peptidase, M16
GSY53_RS05910	COG3391	amine dehydrogenase activity
GSY53_RS05915	COG3391	amine dehydrogenase activity
GSY53_RS05925	COG0457	Tetratricopeptide repeat
GSY53_RS05935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GSY53_RS05940	COG0010	Belongs to the arginase family
GSY53_RS05945	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GSY53_RS05950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSY53_RS05960	COG1994	Peptidase M50
GSY53_RS05965	COG1942	4-Oxalocrotonate Tautomerase
GSY53_RS05970	COG1846	Transcriptional regulator
GSY53_RS05975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GSY53_RS05980	COG0477	Major facilitator Superfamily
GSY53_RS05985	COG1959	2 iron, 2 sulfur cluster binding
GSY53_RS05990	COG3465	dGTPase activity
GSY53_RS05995	COG1078	dGTPase activity
GSY53_RS06000	COG4844	belongs to the
GSY53_RS06010	COG0697	spore germination
GSY53_RS06015	COG0095	Lipoate-protein ligase
GSY53_RS06020	COG0583	DNA-binding transcription factor activity
GSY53_RS06025	COG0280	phosphate acetyltransferase
GSY53_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS06040	COG0436	Aminotransferase
GSY53_RS06045	COG2814	Major facilitator Superfamily
GSY53_RS06050	COG0151	Belongs to the GarS family
GSY53_RS06055	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS06060	COG1917	Cupin 2, conserved barrel domain protein
GSY53_RS06065	COG0077	Prephenate dehydratase
GSY53_RS06070	COG2814	Major facilitator Superfamily
GSY53_RS06075	COG0833	amino acid
GSY53_RS06080	COG4187	Peptidase family M20/M25/M40
GSY53_RS06085	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS06090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GSY53_RS06100	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GSY53_RS06105	COG1091	dTDP-4-dehydrorhamnose reductase activity
GSY53_RS06110	COG1088	dTDP-glucose 4,6-dehydratase activity
GSY53_RS06115	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GSY53_RS06120	COG3980	spore coat polysaccharide biosynthesis protein
GSY53_RS06125	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GSY53_RS06130	COG2089	acid synthase
GSY53_RS06135	COG0456	acetyltransferase
GSY53_RS06140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GSY53_RS06145	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSY53_RS06150	COG0463	Glycosyl transferase, family 2
GSY53_RS06160	COG2363	Small membrane protein
GSY53_RS06165	COG2233	PERMEase
GSY53_RS06175	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS06180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GSY53_RS06185	COG1216	Glycosyl transferase, family 2
GSY53_RS06200	COG1695	Transcriptional regulator
GSY53_RS06205	COG0351	phosphomethylpyrimidine kinase
GSY53_RS06215	COG1621	beta-fructofuranosidase activity
GSY53_RS06220	COG1263	PTS System
GSY53_RS06220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS06225	COG2116	formate transmembrane transporter activity
GSY53_RS06230	COG3711	transcriptional antiterminator
GSY53_RS06240	COG1404	Belongs to the peptidase S8 family
GSY53_RS06245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY53_RS06250	COG0778	Nitroreductase
GSY53_RS06255	COG0772	Belongs to the SEDS family
GSY53_RS06265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GSY53_RS06270	COG1845	cytochrome c oxidase, subunit III
GSY53_RS06275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GSY53_RS06280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GSY53_RS06285	COG2261	transglycosylase associated protein
GSY53_RS06290	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GSY53_RS06295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GSY53_RS06300	COG2246	polysaccharide biosynthetic process
GSY53_RS06305	COG1309	transcriptional regulator
GSY53_RS06315	COG3162	membrane
GSY53_RS06320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY53_RS06325	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GSY53_RS06330	COG2837	iron assimilation
GSY53_RS06335	COG2822	iron ion transport
GSY53_RS06340	COG0672	)-iron permease
GSY53_RS06345	COG0352	thiamine-phosphate diphosphorylase activity
GSY53_RS06350	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GSY53_RS06355	COG0583	DNA-binding transcription factor activity
GSY53_RS06360	COG1380	Effector of murein hydrolase LrgA
GSY53_RS06365	COG1346	cytolysis
GSY53_RS06370	COG2814	Major facilitator Superfamily
GSY53_RS06375	COG4895	conserved protein (DUF2196)
GSY53_RS06380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GSY53_RS06385	COG0346	lactoylglutathione lyase activity
GSY53_RS06400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSY53_RS06405	COG1404	Belongs to the peptidase S8 family
GSY53_RS06410	COG1263	PTS System
GSY53_RS06410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS06415	COG3711	transcriptional antiterminator
GSY53_RS06420	COG1442	glycosyl transferase family 8
GSY53_RS06425	COG5522	Integral membrane protein (intg_mem_TP0381)
GSY53_RS06430	COG1846	Transcriptional regulator
GSY53_RS06435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GSY53_RS06440	COG2234	aminopeptidase activity
GSY53_RS06445	COG2357	RelA SpoT domain protein
GSY53_RS06450	COG1575	Belongs to the MenA family. Type 1 subfamily
GSY53_RS06465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS06470	COG1696	Membrane protein involved in D-alanine export
GSY53_RS06475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSY53_RS06480	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GSY53_RS06485	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GSY53_RS06490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSY53_RS06495	COG1486	melibiose metabolic process
GSY53_RS06500	COG1447	Phosphotransferase system cellobiose-specific component IIA
GSY53_RS06505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSY53_RS06510	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSY53_RS06515	COG3711	transcriptional antiterminator
GSY53_RS06515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY53_RS06525	COG2094	Belongs to the DNA glycosylase MPG family
GSY53_RS06530	COG0753	catalase activity
GSY53_RS06535	COG2814	Major facilitator Superfamily
GSY53_RS06540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GSY53_RS06545	COG1131	(ABC) transporter
GSY53_RS06565	COG1595	DNA-templated transcription, initiation
GSY53_RS06570	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GSY53_RS06575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GSY53_RS06580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GSY53_RS06585	COG4988	ABC transporter
GSY53_RS06590	COG1294	oxidase, subunit
GSY53_RS06595	COG1271	oxidase subunit
GSY53_RS06600	COG3493	citrate carrier protein
GSY53_RS06605	COG0501	Belongs to the peptidase M48B family
GSY53_RS06615	COG0726	polysaccharide deacetylase
GSY53_RS06620	COG3842	ATPase activity
GSY53_RS06625	COG2508	Transcriptional regulator
GSY53_RS06630	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS06635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSY53_RS06645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GSY53_RS06655	COG4585	Histidine kinase
GSY53_RS06660	COG2197	response regulator
GSY53_RS06665	COG2195	Cleaves the N-terminal amino acid of tripeptides
GSY53_RS06675	COG4894	glucomannan catabolic process
GSY53_RS06680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GSY53_RS06685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GSY53_RS06690	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS06695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GSY53_RS06700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GSY53_RS06705	COG2610	gluconate transmembrane transporter activity
GSY53_RS06710	COG0500	methyltransferase
GSY53_RS06715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GSY53_RS06730	COG0693	protein deglycase activity
GSY53_RS06730	COG0753	catalase activity
GSY53_RS06735	COG2851	Citrate transporter
GSY53_RS06740	COG2273	Hydrolase Family 16
GSY53_RS06745	COG3711	transcriptional antiterminator
GSY53_RS06755	COG2270	Major facilitator Superfamily
GSY53_RS06760	COG0513	Belongs to the DEAD box helicase family
GSY53_RS06765	COG3401	FG-GAP repeat protein
GSY53_RS06765	COG2755	lipolytic protein G-D-S-L family
GSY53_RS06820	COG3209	COG3209 Rhs family protein
GSY53_RS06825	COG0697	spore germination
GSY53_RS06830	COG0589	response to stress
GSY53_RS06835	COG2723	6-phospho-beta-galactosidase activity
GSY53_RS06840	COG1263	PTS System
GSY53_RS06840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS06840	COG2190	(PTS) system
GSY53_RS06855	COG5444	nuclease activity
GSY53_RS06870	COG3507	Belongs to the glycosyl hydrolase 43 family
GSY53_RS06880	COG2986	histidine ammonia-lyase
GSY53_RS06885	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GSY53_RS06890	COG1228	amidohydrolase
GSY53_RS06895	COG0010	Belongs to the arginase family
GSY53_RS06900	COG0833	amino acid
GSY53_RS06905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GSY53_RS06910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GSY53_RS06915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GSY53_RS06920	COG2390	Transcriptional regulator
GSY53_RS06930	COG3192	ethanolamine utilization protein
GSY53_RS06935	COG2079	MmgE PrpD family protein
GSY53_RS06945	COG1126	abc transporter atp-binding protein
GSY53_RS06950	COG0765	amino acid transport
GSY53_RS06955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY53_RS06975	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GSY53_RS06980	COG0561	phosphatase activity
GSY53_RS07010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSY53_RS07015	COG5294	Protein conserved in bacteria
GSY53_RS07020	COG0577	efflux transmembrane transporter activity
GSY53_RS07025	COG1136	(ABC) transporter
GSY53_RS07030	COG2205	protein histidine kinase activity
GSY53_RS07035	COG0745	RESPONSE REGULATOR receiver
GSY53_RS07040	COG0191	fructose-bisphosphate aldolase activity
GSY53_RS07045	COG1082	Xylose isomerase domain protein TIM barrel
GSY53_RS07050	COG1082	Xylose isomerase domain protein TIM barrel
GSY53_RS07055	COG0673	inositol 2-dehydrogenase activity
GSY53_RS07060	COG2814	Major facilitator Superfamily
GSY53_RS07065	COG1082	Xylose isomerase domain protein TIM barrel
GSY53_RS07070	COG3962	Belongs to the TPP enzyme family
GSY53_RS07075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY53_RS07080	COG3718	enzyme involved in inositol metabolism
GSY53_RS07085	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS07090	COG1349	DNA-binding transcription factor activity
GSY53_RS07095	COG0667	Aldo Keto reductase
GSY53_RS07110	COG2814	Major facilitator Superfamily
GSY53_RS07115	COG0326	Molecular chaperone. Has ATPase activity
GSY53_RS07125	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS07130	COG1309	transcriptional regulator
GSY53_RS07135	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS07140	COG0456	acetyltransferase
GSY53_RS07145	COG2850	peptidyl-arginine hydroxylation
GSY53_RS07150	COG2226	methyltransferase
GSY53_RS07165	COG0367	asparagine synthase
GSY53_RS07170	COG2814	Major facilitator Superfamily
GSY53_RS07175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GSY53_RS07185	COG1714	RDD family
GSY53_RS07190	COG2311	Membrane
GSY53_RS07195	COG1917	Cupin 2, conserved barrel domain protein
GSY53_RS07200	COG1309	transcriptional regulator
GSY53_RS07205	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS07210	COG1846	Transcriptional regulator
GSY53_RS07215	COG1380	Effector of murein hydrolase LrgA
GSY53_RS07220	COG1346	cytolysis
GSY53_RS07225	COG5039	Polysaccharide pyruvyl transferase
GSY53_RS07230	COG1929	Belongs to the glycerate kinase type-1 family
GSY53_RS07235	COG1802	Transcriptional regulator
GSY53_RS07240	COG1070	Carbohydrate kinase
GSY53_RS07245	COG2610	gluconate transmembrane transporter activity
GSY53_RS07250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GSY53_RS07255	COG0450	alkyl hydroperoxide reductase
GSY53_RS07260	COG3634	alkyl hydroperoxide reductase activity
GSY53_RS07265	COG2723	6-phospho-beta-galactosidase activity
GSY53_RS07270	COG2190	(PTS) system
GSY53_RS07280	COG2188	Transcriptional regulator
GSY53_RS07295	COG1131	(ABC) transporter
GSY53_RS07300	COG1994	Peptidase M50
GSY53_RS07305	COG0535	radical SAM domain protein
GSY53_RS07315	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GSY53_RS07320	COG5293	efflux transmembrane transporter activity
GSY53_RS07330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GSY53_RS07335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GSY53_RS07350	COG1063	alcohol dehydrogenase
GSY53_RS07370	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GSY53_RS07375	COG0456	acetyltransferase
GSY53_RS07380	COG0457	Tetratricopeptide repeat
GSY53_RS07390	COG0010	Belongs to the arginase family
GSY53_RS07395	COG0833	amino acid
GSY53_RS07400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GSY53_RS07405	COG3829	transcription factor binding
GSY53_RS07410	COG5002	protein histidine kinase activity
GSY53_RS07435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSY53_RS07440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GSY53_RS07445	COG4853	Protein conserved in bacteria
GSY53_RS07450	COG4863	YycH protein
GSY53_RS07455	COG5002	protein histidine kinase activity
GSY53_RS07460	COG0745	RESPONSE REGULATOR receiver
GSY53_RS07490	COG0346	lactoylglutathione lyase activity
GSY53_RS07495	COG0305	Participates in initiation and elongation during chromosome replication
GSY53_RS07510	COG3093	addiction module antidote protein HigA
GSY53_RS07515	COG2807	transmembrane transport
GSY53_RS07520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GSY53_RS07525	COG0359	binds to the 23S rRNA
GSY53_RS07530	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GSY53_RS07535	COG4241	membrane
GSY53_RS07545	COG5577	PFAM Coat F domain
GSY53_RS07550	COG1733	regulation of RNA biosynthetic process
GSY53_RS07555	COG1227	inorganic diphosphatase activity
GSY53_RS07565	COG2271	Major facilitator Superfamily
GSY53_RS07570	COG4978	Transcriptional regulator
GSY53_RS07570	COG0789	Transcriptional regulator
GSY53_RS07580	COG4319	ketosteroid isomerase
GSY53_RS07585	COG1357	PFAM Pentapeptide repeats (8 copies)
GSY53_RS07590	COG2814	Major facilitator Superfamily
GSY53_RS07595	COG0583	DNA-binding transcription factor activity
GSY53_RS07600	COG2153	protein acetylation
GSY53_RS07610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSY53_RS07615	COG1846	Transcriptional regulator
GSY53_RS07620	COG2153	protein acetylation
GSY53_RS07625	COG2364	Membrane
GSY53_RS07630	COG0456	acetyltransferase
GSY53_RS07635	COG2315	Protein conserved in bacteria
GSY53_RS07640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GSY53_RS07650	COG2814	Major facilitator Superfamily
GSY53_RS07660	COG1331	Highly conserved protein containing a thioredoxin domain
GSY53_RS07665	COG0789	Transcriptional regulator
GSY53_RS07670	COG0697	spore germination
GSY53_RS07675	COG1331	Highly conserved protein containing a thioredoxin domain
GSY53_RS07680	COG1266	CAAX protease self-immunity
GSY53_RS07685	COG0477	Major facilitator Superfamily
GSY53_RS07685	COG2814	Major facilitator Superfamily
GSY53_RS07690	COG0110	maltose O-acetyltransferase activity
GSY53_RS07695	COG0346	lactoylglutathione lyase activity
GSY53_RS07700	COG1609	Transcriptional regulator
GSY53_RS07705	COG0708	Exodeoxyribonuclease III
GSY53_RS07710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GSY53_RS07715	COG0629	single-stranded DNA binding
GSY53_RS07720	COG0360	Binds together with S18 to 16S ribosomal RNA
GSY53_RS07725	COG0012	GTP binding
GSY53_RS07730	COG0243	molybdopterin cofactor binding
GSY53_RS07735	COG4481	Protein conserved in bacteria
GSY53_RS07740	COG3949	Membrane
GSY53_RS07750	COG1475	DNA binding
GSY53_RS07755	COG1192	Involved in chromosome partitioning
GSY53_RS07765	COG1475	DNA binding
GSY53_RS07770	COG0357	Ribosomal RNA small subunit methyltransferase G
GSY53_RS07775	COG0445	tRNA wobble uridine modification
GSY53_RS07780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GSY53_RS07785	COG1847	R3H domain protein
GSY53_RS07790	COG0706	membrane insertase activity
GSY53_RS07795	COG0594	ribonuclease P activity
GSY53_RS07800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GSY53_RS07805	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GSY53_RS07810	COG0592	DNA-directed DNA polymerase activity
GSY53_RS07815	COG2501	S4 domain
GSY53_RS07820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GSY53_RS07830	COG0187	DNA topoisomerase II activity
GSY53_RS07835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GSY53_RS07870	COG0516	GMP reductase activity
GSY53_RS07870	COG0517	IMP dehydrogenase activity
GSY53_RS07875	COG1686	Belongs to the peptidase S11 family
GSY53_RS07880	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GSY53_RS07885	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GSY53_RS07890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GSY53_RS07900	COG1428	Deoxynucleoside kinase
GSY53_RS07905	COG1428	Deoxynucleoside kinase
GSY53_RS07910	COG3858	chitin binding
GSY53_RS07910	COG1388	LysM domain
GSY53_RS07915	COG1335	isochorismatase
GSY53_RS07920	COG0590	tRNA wobble adenosine to inosine editing
GSY53_RS07930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GSY53_RS07935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GSY53_RS07940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GSY53_RS07985	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GSY53_RS07990	COG3853	Toxic anion resistance protein (TelA)
GSY53_RS07995	COG1982	Orn Lys Arg decarboxylase major
GSY53_RS08000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GSY53_RS08005	COG3870	Protein conserved in bacteria
GSY53_RS08010	COG1728	Protein conserved in bacteria
GSY53_RS08015	COG0470	DNA polymerase III
GSY53_RS08020	COG1774	PSP1 C-terminal conserved region
GSY53_RS08025	COG4467	Involved in initiation control of chromosome replication
GSY53_RS08030	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GSY53_RS08035	COG2827	Endonuclease containing a URI domain
GSY53_RS08040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GSY53_RS08045	COG2002	toxin-antitoxin pair type II binding
GSY53_RS08050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSY53_RS08050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSY53_RS08055	COG0084	hydrolase, TatD family'
GSY53_RS08060	COG3584	3D domain protein
GSY53_RS08060	COG3583	domain protein
GSY53_RS08065	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GSY53_RS08070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GSY53_RS08080	COG4466	Protein conserved in bacteria
GSY53_RS08090	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GSY53_RS08095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSY53_RS08100	COG0251	oxidation-reduction process
GSY53_RS08105	COG2088	sporulation resulting in formation of a cellular spore
GSY53_RS08110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GSY53_RS08115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GSY53_RS08120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GSY53_RS08125	COG0193	aminoacyl-tRNA hydrolase activity
GSY53_RS08135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GSY53_RS08140	COG2002	toxin-antitoxin pair type II binding
GSY53_RS08145	COG2244	polysaccharide biosynthetic process
GSY53_RS08150	COG3956	TIGRFAM MazG family protein
GSY53_RS08155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GSY53_RS08170	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GSY53_RS08175	COG1098	S1 RNA binding domain
GSY53_RS08190	COG2208	phosphoserine phosphatase activity
GSY53_RS08195	COG2304	oxidoreductase activity
GSY53_RS08200	COG0515	serine threonine protein kinase
GSY53_RS08205	COG0037	tRNA processing
GSY53_RS08215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GSY53_RS08220	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GSY53_RS08225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GSY53_RS08230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSY53_RS08235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GSY53_RS08240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GSY53_RS08245	COG0512	Glutamine amidotransferase of anthranilate synthase
GSY53_RS08250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSY53_RS08255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GSY53_RS08260	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GSY53_RS08265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GSY53_RS08270	COG1396	sequence-specific DNA binding
GSY53_RS08275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GSY53_RS08280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GSY53_RS08360	COG4463	regulation of RNA biosynthetic process
GSY53_RS08365	COG3880	PFAM UvrB UvrC protein
GSY53_RS08370	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GSY53_RS08375	COG0542	response to heat
GSY53_RS08380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GSY53_RS08385	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GSY53_RS08390	COG4956	integral membrane protein (PIN domain superfamily)
GSY53_RS08395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GSY53_RS08400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GSY53_RS08405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSY53_RS08410	COG1045	serine acetyltransferase
GSY53_RS08415	COG0215	cysteine-tRNA ligase activity
GSY53_RS08420	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GSY53_RS08425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSY53_RS08430	COG3688	RNA-binding protein containing a PIN domain
GSY53_RS08435	COG1595	DNA-templated transcription, initiation
GSY53_RS08440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GSY53_RS08445	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSY53_RS08450	COG0250	Participates in transcription elongation, termination and antitermination
GSY53_RS08455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GSY53_RS08460	COG0081	regulation of translation
GSY53_RS08465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GSY53_RS08470	COG0222	ribosome binding
GSY53_RS08475	COG2813	Specifically methylates the guanine in position
GSY53_RS08480	COG0085	RNA polymerase activity
GSY53_RS08485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GSY53_RS08490	COG1358	cellular component organization or biogenesis
GSY53_RS08495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GSY53_RS08500	COG0049	tRNA binding
GSY53_RS08505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GSY53_RS08510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GSY53_RS08515	COG0596	Alpha beta hydrolase
GSY53_RS08520	COG0051	transcription antitermination factor activity, RNA binding
GSY53_RS08525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GSY53_RS08530	COG0088	Forms part of the polypeptide exit tunnel
GSY53_RS08535	COG0089	rRNA binding
GSY53_RS08540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GSY53_RS08545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GSY53_RS08550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GSY53_RS08555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GSY53_RS08560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GSY53_RS08565	COG0255	Belongs to the universal ribosomal protein uL29 family
GSY53_RS08570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GSY53_RS08575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GSY53_RS08585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GSY53_RS08595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GSY53_RS08600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GSY53_RS08605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GSY53_RS08610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GSY53_RS08615	COG1841	ribosomal large subunit assembly
GSY53_RS08620	COG0200	Binds to the 23S rRNA
GSY53_RS08625	COG0201	protein transport
GSY53_RS08630	COG0563	adenylate kinase activity
GSY53_RS08635	COG0024	Methionine aminopeptidase
GSY53_RS08640	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GSY53_RS08645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GSY53_RS08650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GSY53_RS08655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GSY53_RS08660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GSY53_RS08665	COG0202	RNA polymerase activity
GSY53_RS08670	COG0203	ribosomal protein L17
GSY53_RS08675	COG1122	ATPase activity
GSY53_RS08680	COG1122	ATPase activity
GSY53_RS08685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GSY53_RS08690	COG0101	tRNA pseudouridine synthase activity
GSY53_RS08695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GSY53_RS08700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GSY53_RS08705	COG2226	methyltransferase
GSY53_RS08715	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS08720	COG0489	protein tyrosine kinase activity
GSY53_RS08730	COG2194	sulfuric ester hydrolase activity
GSY53_RS08735	COG0726	polysaccharide deacetylase
GSY53_RS08815	COG0659	secondary active sulfate transmembrane transporter activity
GSY53_RS08820	COG0385	Bile acid
GSY53_RS08825	COG2819	hydrolase of the alpha beta superfamily
GSY53_RS08830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS08835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS08840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSY53_RS08845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSY53_RS08845	COG2207	Transcriptional regulator
GSY53_RS08850	COG3876	Protein conserved in bacteria
GSY53_RS08855	COG1472	Belongs to the glycosyl hydrolase 3 family
GSY53_RS08860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GSY53_RS08865	COG1263	PTS System
GSY53_RS08865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS08870	COG1737	Transcriptional regulator
GSY53_RS08875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GSY53_RS08880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY53_RS08885	COG1683	Conserved Protein
GSY53_RS08915	COG1595	DNA-templated transcription, initiation
GSY53_RS08920	COG5662	AntiSigma factor
GSY53_RS08925	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GSY53_RS08930	COG4856	YbbR-like protein
GSY53_RS08935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSY53_RS08940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GSY53_RS08950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GSY53_RS08955	COG2169	Transcriptional regulator
GSY53_RS08960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GSY53_RS08965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GSY53_RS08970	COG3002	Belongs to the UPF0753 family
GSY53_RS08975	COG0288	reversible hydration of carbon dioxide
GSY53_RS08985	COG5609	conserved protein (DUF2294)
GSY53_RS08990	COG0640	Transcriptional regulator
GSY53_RS08995	COG2814	Major facilitator Superfamily
GSY53_RS09000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GSY53_RS09010	COG0535	radical SAM domain protein
GSY53_RS09015	COG1266	CAAX protease self-immunity
GSY53_RS09020	COG1131	(ABC) transporter
GSY53_RS09030	COG1413	lyase activity
GSY53_RS09035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS09040	COG0596	Alpha beta hydrolase
GSY53_RS09045	COG0745	RESPONSE REGULATOR receiver
GSY53_RS09050	COG0642	Histidine kinase
GSY53_RS09060	COG0515	serine threonine protein kinase
GSY53_RS09075	COG1113	amino acid transport
GSY53_RS09090	COG2602	Beta-lactamase
GSY53_RS09095	COG2124	cytochrome p450
GSY53_RS09105	COG0531	amino acid
GSY53_RS09110	COG0584	glycerophosphoryl diester phosphodiesterase
GSY53_RS09115	COG2271	Major facilitator Superfamily
GSY53_RS09125	COG0456	acetyltransferase
GSY53_RS09125	COG1846	Transcriptional regulator
GSY53_RS09130	COG2271	Major facilitator Superfamily
GSY53_RS09145	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS09150	COG0697	spore germination
GSY53_RS09155	COG1917	Cupin 2, conserved barrel domain protein
GSY53_RS09155	COG2207	Transcriptional regulator
GSY53_RS09160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GSY53_RS09165	COG3591	Belongs to the peptidase S1B family
GSY53_RS09175	COG0596	Alpha beta hydrolase
GSY53_RS09180	COG1183	phosphatidylcholine synthase activity
GSY53_RS09185	COG0586	Pfam SNARE associated Golgi protein
GSY53_RS09190	COG0688	phosphatidylethanolamine metabolic process
GSY53_RS09200	COG2312	Erythromycin esterase
GSY53_RS09205	COG2207	Transcriptional regulator
GSY53_RS09215	COG1301	dicarboxylic acid transport
GSY53_RS09220	COG2190	(PTS) system
GSY53_RS09220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS09220	COG1263	PTS System
GSY53_RS09225	COG0363	glucosamine-6-phosphate deaminase activity
GSY53_RS09240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSY53_RS09245	COG0833	amino acid
GSY53_RS09250	COG2040	homocysteine
GSY53_RS09260	COG1115	amino acid carrier protein
GSY53_RS09265	COG2066	Belongs to the glutaminase family
GSY53_RS09270	COG4191	Histidine kinase
GSY53_RS09275	COG0784	Response regulator, receiver
GSY53_RS09280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSY53_RS09285	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS09290	COG2271	Major facilitator Superfamily
GSY53_RS09295	COG4948	Mandelate Racemase Muconate Lactonizing
GSY53_RS09300	COG2186	Transcriptional regulator
GSY53_RS09305	COG2721	sulfolactate sulfo-lyase activity
GSY53_RS09310	COG3173	Aminoglycoside phosphotransferase
GSY53_RS09320	COG0697	spore germination
GSY53_RS09325	COG0745	RESPONSE REGULATOR receiver
GSY53_RS09330	COG2205	protein histidine kinase activity
GSY53_RS09335	COG1131	(ABC) transporter
GSY53_RS09355	COG3773	Cell wall hydrolase
GSY53_RS09360	COG2304	oxidoreductase activity
GSY53_RS09370	COG3540	Alkaline phosphatase
GSY53_RS09375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSY53_RS09380	COG0805	protein transport
GSY53_RS09385	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GSY53_RS09390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSY53_RS09395	COG0477	Major facilitator Superfamily
GSY53_RS09400	COG1309	transcriptional regulator
GSY53_RS09405	COG0252	asparaginase activity
GSY53_RS09410	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GSY53_RS09415	COG1714	RDD family
GSY53_RS09420	COG3012	SEC-C Motif Domain Protein
GSY53_RS09420	COG1405	negative regulation of cell septum assembly
GSY53_RS09425	COG3290	protein histidine kinase activity
GSY53_RS09430	COG3279	Response regulator of the LytR AlgR family
GSY53_RS09435	COG4555	ABC transporter
GSY53_RS09440	COG1668	transmembrane transport
GSY53_RS09445	COG0667	Aldo Keto reductase
GSY53_RS09460	COG1595	DNA-templated transcription, initiation
GSY53_RS09465	COG1595	DNA-templated transcription, initiation
GSY53_RS09470	COG1876	peptidase activity
GSY53_RS09475	COG0457	Tetratricopeptide repeat
GSY53_RS09480	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS09485	COG0366	Alpha amylase catalytic
GSY53_RS09490	COG0803	Belongs to the bacterial solute-binding protein 9 family
GSY53_RS09495	COG1121	(ABC) transporter
GSY53_RS09500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSY53_RS09505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY53_RS09510	COG2310	stress, protein
GSY53_RS09515	COG2310	stress, protein
GSY53_RS09520	COG2310	stress, protein
GSY53_RS09525	COG0861	Integral membrane protein TerC family
GSY53_RS09535	COG3853	Toxic anion resistance protein (TelA)
GSY53_RS09540	COG0477	Major facilitator Superfamily
GSY53_RS09545	COG2814	Major facilitator Superfamily
GSY53_RS09550	COG0640	Transcriptional regulator
GSY53_RS09555	COG4175	Glycine betaine
GSY53_RS09555	COG0517	IMP dehydrogenase activity
GSY53_RS09560	COG4176	ABC-type proline glycine betaine transport system permease component
GSY53_RS09565	COG2113	Glycine betaine
GSY53_RS09570	COG1473	amidohydrolase
GSY53_RS09575	COG1288	antiporter activity
GSY53_RS09585	COG0366	Alpha amylase catalytic
GSY53_RS09590	COG0039	L-malate dehydrogenase activity
GSY53_RS09600	COG2814	Major facilitator Superfamily
GSY53_RS09605	COG1846	Transcriptional regulator
GSY53_RS09610	COG1280	lysine exporter protein (LysE YggA)
GSY53_RS09615	COG3403	YqcI/YcgG family
GSY53_RS09620	COG1113	amino acid transport
GSY53_RS09625	COG3665	Urea carboxylase-associated protein
GSY53_RS09630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GSY53_RS09635	COG1660	Displays ATPase and GTPase activities
GSY53_RS09640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSY53_RS09645	COG2226	methyltransferase
GSY53_RS09650	COG0583	DNA-binding transcription factor activity
GSY53_RS09655	COG3458	cephalosporin-C deacetylase activity
GSY53_RS09660	COG3541	Predicted nucleotidyltransferase
GSY53_RS09665	COG0506	proline dehydrogenase activity
GSY53_RS09670	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS09675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY53_RS09680	COG2508	Transcriptional regulator
GSY53_RS09690	COG0701	Predicted permease
GSY53_RS09695	COG2267	carboxylic ester hydrolase activity
GSY53_RS09700	COG0492	ferredoxin-NADP+ reductase activity
GSY53_RS09705	COG1587	Uroporphyrinogen-III synthase
GSY53_RS09705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSY53_RS09710	COG2146	nitrite reductase [NAD(P)H] activity
GSY53_RS09715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSY53_RS09720	COG0243	molybdopterin cofactor binding
GSY53_RS09725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSY53_RS09730	COG2223	nitrite transmembrane transporter activity
GSY53_RS09735	COG1469	GTP cyclohydrolase I activity
GSY53_RS09740	COG1376	ErfK ybiS ycfS ynhG family protein
GSY53_RS09750	COG0523	cobalamin synthesis protein
GSY53_RS09755	COG0765	amino acid transport
GSY53_RS09760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY53_RS09780	COG2723	6-phospho-beta-galactosidase activity
GSY53_RS09790	COG3209	COG3209 Rhs family protein
GSY53_RS09795	COG3290	protein histidine kinase activity
GSY53_RS09795	COG0840	transmembrane signaling receptor activity
GSY53_RS09800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GSY53_RS09805	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GSY53_RS09810	COG1733	regulation of RNA biosynthetic process
GSY53_RS09815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS09820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS09825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS09830	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GSY53_RS09835	COG2814	Major facilitator Superfamily
GSY53_RS09845	COG0697	spore germination
GSY53_RS09850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY53_RS09860	COG2364	Membrane
GSY53_RS09865	COG1126	abc transporter atp-binding protein
GSY53_RS09870	COG0765	amino acid transport
GSY53_RS09875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY53_RS09880	COG0583	DNA-binding transcription factor activity
GSY53_RS09885	COG0163	prenyltransferase activity
GSY53_RS09890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GSY53_RS09905	COG0596	Alpha beta hydrolase
GSY53_RS09910	COG3104	oligopeptide transport
GSY53_RS09915	COG5434	Belongs to the glycosyl hydrolase 28 family
GSY53_RS09925	COG0697	spore germination
GSY53_RS09935	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GSY53_RS09940	COG1136	(ABC) transporter
GSY53_RS09945	COG0577	efflux transmembrane transporter activity
GSY53_RS09950	COG0745	RESPONSE REGULATOR receiver
GSY53_RS09955	COG3850	Histidine kinase
GSY53_RS09955	COG5002	protein histidine kinase activity
GSY53_RS09960	COG0457	Tetratricopeptide repeat
GSY53_RS09980	COG0527	aspartate kinase activity
GSY53_RS09985	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS09990	COG4605	iron ion homeostasis
GSY53_RS09995	COG4604	ABC transporter, ATP-binding protein
GSY53_RS10000	COG4607	ABC-type enterochelin transport system periplasmic component
GSY53_RS10005	COG2814	Major facilitator Superfamily
GSY53_RS10010	COG1309	transcriptional regulator
GSY53_RS10015	COG0778	Nitroreductase
GSY53_RS10020	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GSY53_RS10025	COG0640	Transcriptional regulator
GSY53_RS10030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY53_RS10035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GSY53_RS10040	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS10045	COG4975	Glucose uptake
GSY53_RS10050	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS10055	COG4549	nuclear export factor GLE1
GSY53_RS10060	COG2372	response to copper ion
GSY53_RS10060	COG1276	copper resistance
GSY53_RS10065	COG1349	DNA-binding transcription factor activity
GSY53_RS10075	COG2213	PTS system mannitol-specific
GSY53_RS10080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY53_RS10085	COG0246	Mannitol dehydrogenase
GSY53_RS10090	COG0473	3-isopropylmalate dehydrogenase activity
GSY53_RS10095	COG0681	Belongs to the peptidase S26 family
GSY53_RS10100	COG0412	Dienelactone hydrolase
GSY53_RS10105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GSY53_RS10115	COG0561	phosphatase activity
GSY53_RS10120	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GSY53_RS10125	COG1914	H( )-stimulated, divalent metal cation uptake system
GSY53_RS10130	COG4336	lyase activity
GSY53_RS10135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GSY53_RS10140	COG1984	allophanate hydrolase subunit 2
GSY53_RS10145	COG1414	Transcriptional regulator
GSY53_RS10150	COG2755	lipolytic protein G-D-S-L family
GSY53_RS10160	COG2329	Antibiotic biosynthesis monooxygenase
GSY53_RS10165	COG0768	penicillin binding
GSY53_RS10170	COG4989	oxidoreductase activity
GSY53_RS10175	COG3711	transcriptional antiterminator
GSY53_RS10180	COG0318	PFAM AMP-dependent synthetase and ligase
GSY53_RS10185	COG2226	methyltransferase
GSY53_RS10190	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS10195	COG1917	Cupin 2, conserved barrel domain protein
GSY53_RS10200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY53_RS10205	COG3871	stress protein (general stress protein 26)
GSY53_RS10215	COG2814	Major facilitator Superfamily
GSY53_RS10220	COG1522	sequence-specific DNA binding
GSY53_RS10225	COG0551	DNA topoisomerase type I activity
GSY53_RS10225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GSY53_RS10230	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GSY53_RS10235	COG3706	GGDEF domain
GSY53_RS10240	COG5298	Protein conserved in bacteria
GSY53_RS10245	COG1215	transferase activity, transferring glycosyl groups
GSY53_RS10255	COG0531	amino acid
GSY53_RS10260	COG0494	nUDIX hydrolase
GSY53_RS10265	COG0028	Belongs to the TPP enzyme family
GSY53_RS10280	COG1914	H( )-stimulated, divalent metal cation uptake system
GSY53_RS10285	COG2261	transglycosylase associated protein
GSY53_RS10290	COG4876	unkown
GSY53_RS10295	COG2217	Heavy metal translocating P-type atpase
GSY53_RS10300	COG3729	General stress protein
GSY53_RS10305	COG0662	Cupin 2, conserved barrel domain protein
GSY53_RS10310	COG2329	Antibiotic biosynthesis monooxygenase
GSY53_RS10315	COG3546	catalase activity
GSY53_RS10320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GSY53_RS10325	COG3290	protein histidine kinase activity
GSY53_RS10330	COG4565	transcriptional regulatory protein
GSY53_RS10335	COG1301	dicarboxylic acid transport
GSY53_RS10340	COG0628	permease
GSY53_RS10345	COG1131	(ABC) transporter
GSY53_RS10350	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GSY53_RS10360	COG1960	acyl-CoA dehydrogenase activity
GSY53_RS10375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GSY53_RS10380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS10385	COG1181	Belongs to the D-alanine--D-alanine ligase family
GSY53_RS10390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GSY53_RS10395	COG0513	Belongs to the DEAD box helicase family
GSY53_RS10400	COG3402	PFAM membrane-flanked domain
GSY53_RS10405	COG3428	Bacterial PH domain
GSY53_RS10410	COG0705	Rhomboid family
GSY53_RS10415	COG0736	holo-[acyl-carrier-protein] synthase activity
GSY53_RS10420	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GSY53_RS10425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GSY53_RS10430	COG0864	Transcriptional regulator
GSY53_RS10435	COG2337	Toxic component of a toxin-antitoxin (TA) module
GSY53_RS10440	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY53_RS10445	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY53_RS10450	COG2172	sigma factor antagonist activity
GSY53_RS10455	COG2208	phosphoserine phosphatase activity
GSY53_RS10460	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY53_RS10465	COG2172	sigma factor antagonist activity
GSY53_RS10470	COG1191	sigma factor activity
GSY53_RS10475	COG2208	phosphoserine phosphatase activity
GSY53_RS10490	COG1673	EVE domain
GSY53_RS10495	COG1846	Transcriptional regulator
GSY53_RS10500	COG2183	response to ionizing radiation
GSY53_RS10510	COG3091	SprT-like family
GSY53_RS10550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY53_RS10555	COG1522	sequence-specific DNA binding
GSY53_RS10560	COG1522	sequence-specific DNA binding
GSY53_RS10565	COG1335	isochorismatase
GSY53_RS10570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GSY53_RS10575	COG2814	Major facilitator Superfamily
GSY53_RS10595	COG0693	protein deglycase activity
GSY53_RS10600	COG1278	Cold shock
GSY53_RS10605	COG1329	Transcriptional regulator
GSY53_RS10615	COG2207	Transcriptional regulator
GSY53_RS10615	COG1917	Cupin 2, conserved barrel domain protein
GSY53_RS10620	COG0697	spore germination
GSY53_RS10625	COG2207	Transcriptional regulator
GSY53_RS10625	COG3708	Transcriptional regulator
GSY53_RS10630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY53_RS10635	COG0477	Major facilitator Superfamily
GSY53_RS10645	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GSY53_RS10655	COG0697	spore germination
GSY53_RS10660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY53_RS10665	COG2030	dehydratase
GSY53_RS10670	COG3545	Serine hydrolase
GSY53_RS10675	COG1733	regulation of RNA biosynthetic process
GSY53_RS10680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSY53_RS10685	COG1733	regulation of RNA biosynthetic process
GSY53_RS10690	COG2249	NAD(P)H dehydrogenase (quinone) activity
GSY53_RS10695	COG2814	Major facilitator Superfamily
GSY53_RS10700	COG1309	transcriptional regulator
GSY53_RS10710	COG0640	Transcriptional regulator
GSY53_RS10715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GSY53_RS10725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY53_RS10730	COG0697	spore germination
GSY53_RS10735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY53_RS10740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GSY53_RS10745	COG0640	Transcriptional regulator
GSY53_RS10750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSY53_RS10765	COG4585	Histidine kinase
GSY53_RS10770	COG2197	response regulator
GSY53_RS10775	COG2409	Drug exporters of the RND superfamily
GSY53_RS10780	COG0596	Alpha beta hydrolase
GSY53_RS10785	COG1811	Na channel or pump
GSY53_RS10790	COG4978	Transcriptional regulator
GSY53_RS10790	COG0789	Transcriptional regulator
GSY53_RS10795	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GSY53_RS10800	COG0778	Nitroreductase
GSY53_RS10805	COG0346	lactoylglutathione lyase activity
GSY53_RS10810	COG2259	Doxx family
GSY53_RS10815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS10830	COG2323	membrane
GSY53_RS10835	COG2323	membrane
GSY53_RS10840	COG0071	Belongs to the small heat shock protein (HSP20) family
GSY53_RS10855	COG1309	transcriptional regulator
GSY53_RS10865	COG0456	acetyltransferase
GSY53_RS10875	COG1113	amino acid transport
GSY53_RS10880	COG2318	DinB family
GSY53_RS10885	COG1846	Transcriptional regulator
GSY53_RS10890	COG2409	Drug exporters of the RND superfamily
GSY53_RS10890	COG1033	growth of symbiont in host cell
GSY53_RS10895	COG0778	Nitroreductase
GSY53_RS10900	COG1846	Transcriptional regulator
GSY53_RS10905	COG2814	Major facilitator Superfamily
GSY53_RS10910	COG0730	response to heat
GSY53_RS10915	COG1802	Transcriptional regulator
GSY53_RS10920	COG1388	LysM domain
GSY53_RS10920	COG3858	chitin binding
GSY53_RS10925	COG1819	glycosyl
GSY53_RS10935	COG1785	Belongs to the alkaline phosphatase family
GSY53_RS10940	COG5646	InterPro IPR014922
GSY53_RS10950	COG0454	-acetyltransferase
GSY53_RS10955	COG1078	dGTPase activity
GSY53_RS10960	COG1388	LysM domain
GSY53_RS10965	COG2814	Major facilitator Superfamily
GSY53_RS10970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSY53_RS10975	COG1447	Phosphotransferase system cellobiose-specific component IIA
GSY53_RS10980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSY53_RS10985	COG2723	6-phospho-beta-galactosidase activity
GSY53_RS10990	COG2188	Transcriptional regulator
GSY53_RS10995	COG1940	carbohydrate kinase activity
GSY53_RS11000	COG1482	cell wall glycoprotein biosynthetic process
GSY53_RS11005	COG4124	Belongs to the glycosyl hydrolase 26 family
GSY53_RS11050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GSY53_RS11055	COG0802	atpase or kinase
GSY53_RS11060	COG1214	PFAM Peptidase M22, glycoprotease
GSY53_RS11065	COG0456	acetyltransferase
GSY53_RS11070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GSY53_RS11075	COG0488	(ABC) transporter
GSY53_RS11080	COG0315	cyclic pyranopterin monophosphate synthase activity
GSY53_RS11085	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GSY53_RS11090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSY53_RS11095	COG0805	protein transport
GSY53_RS11105	COG1266	CAAX protease self-immunity
GSY53_RS11110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GSY53_RS11115	COG0459	protein refolding
GSY53_RS11125	COG3378	Phage plasmid primase P4 family
GSY53_RS11140	COG0270	DNA (cytosine-5-)-methyltransferase activity
GSY53_RS11145	COG0270	DNA (cytosine-5-)-methyltransferase activity
GSY53_RS11165	COG1401	restriction endodeoxyribonuclease activity
GSY53_RS11180	COG1073	alpha beta
GSY53_RS11185	COG0457	Tetratricopeptide repeat
GSY53_RS11190	COG1063	alcohol dehydrogenase
GSY53_RS11195	COG2211	Major facilitator Superfamily
GSY53_RS11200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY53_RS11205	COG1842	Phage shock protein A
GSY53_RS11210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GSY53_RS11215	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GSY53_RS11220	COG4260	virion core protein, lumpy skin disease virus
GSY53_RS11230	COG2814	Major facilitator Superfamily
GSY53_RS11235	COG1063	alcohol dehydrogenase
GSY53_RS11240	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GSY53_RS11245	COG0823	Involved in the tonB-independent uptake of proteins
GSY53_RS11260	COG2267	carboxylic ester hydrolase activity
GSY53_RS11270	COG2132	Multicopper oxidase
GSY53_RS11275	COG1113	amino acid transport
GSY53_RS11285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GSY53_RS11290	COG0714	Associated with various cellular activities
GSY53_RS11295	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GSY53_RS11300	COG1305	Transglutaminase-like
GSY53_RS11305	COG0519	Catalyzes the synthesis of GMP from XMP
GSY53_RS11305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GSY53_RS11310	COG2252	PERMEase
GSY53_RS11315	COG3064	Membrane
GSY53_RS11325	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GSY53_RS11335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GSY53_RS11340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GSY53_RS11345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GSY53_RS11350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GSY53_RS11355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GSY53_RS11360	COG0047	phosphoribosylformylglycinamidine synthase activity
GSY53_RS11365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GSY53_RS11370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GSY53_RS11375	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GSY53_RS11380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GSY53_RS11385	COG0138	bifunctional purine biosynthesis protein purh
GSY53_RS11390	COG0151	Belongs to the GarS family
GSY53_RS11395	COG1522	sequence-specific DNA binding
GSY53_RS11400	COG0531	amino acid
GSY53_RS11410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GSY53_RS11415	COG1470	cell adhesion involved in biofilm formation
GSY53_RS11420	COG4496	protein, YerC YecD
GSY53_RS11425	COG0069	glutamate synthase activity
GSY53_RS11430	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GSY53_RS11435	COG0210	DNA helicase
GSY53_RS11440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GSY53_RS11445	COG4851	CamS sex pheromone cAM373 precursor
GSY53_RS11450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GSY53_RS11455	COG1285	pathogenesis
GSY53_RS11460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY53_RS11465	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSY53_RS11470	COG0154	amidase activity
GSY53_RS11475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSY53_RS11480	COG1309	transcriptional regulator
GSY53_RS11485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSY53_RS11490	COG1597	lipid kinase activity
GSY53_RS11495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSY53_RS11500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GSY53_RS11505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GSY53_RS11510	COG1002	Type II restriction enzyme, methylase subunits
GSY53_RS11515	COG1061	Type III restriction enzyme res subunit
GSY53_RS11520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GSY53_RS11540	COG5444	nuclease activity
GSY53_RS11560	COG0457	Tetratricopeptide repeat
GSY53_RS11570	COG0217	transcriptional regulatory protein
GSY53_RS11580	COG1309	transcriptional regulator
GSY53_RS11585	COG3631	Ketosteroid isomerase-related protein
GSY53_RS11590	COG0702	epimerase
GSY53_RS11605	COG3546	catalase activity
GSY53_RS11610	COG0454	-acetyltransferase
GSY53_RS11620	COG5578	integral membrane protein
GSY53_RS11625	COG2972	Histidine kinase
GSY53_RS11630	COG4753	response regulator
GSY53_RS11630	COG2207	Transcriptional regulator
GSY53_RS11635	COG1653	transport
GSY53_RS11640	COG1175	transmembrane transport
GSY53_RS11645	COG0395	ABC-type sugar transport system, permease component
GSY53_RS11650	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GSY53_RS11655	COG2207	Transcriptional regulator
GSY53_RS11660	COG2755	lipolytic protein G-D-S-L family
GSY53_RS11670	COG5578	integral membrane protein
GSY53_RS11675	COG3401	FG-GAP repeat protein
GSY53_RS11680	COG3401	FG-GAP repeat protein
GSY53_RS11685	COG2755	lipolytic protein G-D-S-L family
GSY53_RS11690	COG1874	Beta-galactosidase
GSY53_RS11700	COG1653	transport
GSY53_RS11705	COG4209	transmembrane transport
GSY53_RS11710	COG0395	ABC-type sugar transport system, permease component
GSY53_RS11715	COG1486	melibiose metabolic process
GSY53_RS11720	COG2323	membrane
GSY53_RS11725	COG2329	Antibiotic biosynthesis monooxygenase
GSY53_RS11730	COG0346	lactoylglutathione lyase activity
GSY53_RS11745	COG5583	Uncharacterized small protein (DUF2292)
GSY53_RS11750	COG0670	Belongs to the BI1 family
GSY53_RS11755	COG0697	spore germination
GSY53_RS11760	COG1846	Transcriptional regulator
GSY53_RS11765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSY53_RS11775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GSY53_RS11775	COG2124	cytochrome p450
GSY53_RS11780	COG1368	sulfuric ester hydrolase activity
GSY53_RS11785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GSY53_RS11790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSY53_RS11795	COG1442	glycosyl transferase family 8
GSY53_RS11800	COG1216	Glycosyl transferase, family 2
GSY53_RS11805	COG1442	glycosyl transferase family 8
GSY53_RS11815	COG1011	Hydrolase
GSY53_RS11820	COG0531	amino acid
GSY53_RS11825	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS11830	COG0840	transmembrane signaling receptor activity
GSY53_RS11835	COG0488	(ABC) transporter
GSY53_RS11845	COG0789	Transcriptional regulator
GSY53_RS11850	COG2814	Major facilitator Superfamily
GSY53_RS11860	COG0488	(ABC) transporter
GSY53_RS11865	COG0513	Belongs to the DEAD box helicase family
GSY53_RS11870	COG0456	acetyltransferase
GSY53_RS11875	COG2130	NADP-dependent
GSY53_RS11880	COG2211	Major facilitator Superfamily
GSY53_RS11885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GSY53_RS11890	COG1120	ATPase activity
GSY53_RS11895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS11900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS11905	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GSY53_RS11920	COG3866	Pectate lyase
GSY53_RS11925	COG0471	metal ion transport
GSY53_RS11930	COG3290	protein histidine kinase activity
GSY53_RS11935	COG4565	transcriptional regulatory protein
GSY53_RS11940	COG3181	Tripartite tricarboxylate transporter family receptor
GSY53_RS11945	COG2851	Citrate transporter
GSY53_RS11950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSY53_RS11955	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GSY53_RS11960	COG1254	Belongs to the acylphosphatase family
GSY53_RS11965	COG2258	MOSC domain
GSY53_RS11985	COG0024	Methionine aminopeptidase
GSY53_RS11990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS11990	COG1263	PTS System
GSY53_RS11995	COG1368	sulfuric ester hydrolase activity
GSY53_RS12010	COG1115	amino acid carrier protein
GSY53_RS12015	COG0531	amino acid
GSY53_RS12030	COG0697	spore germination
GSY53_RS12035	COG1263	PTS System
GSY53_RS12035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS12040	COG0366	Alpha amylase catalytic
GSY53_RS12045	COG2188	Transcriptional regulator
GSY53_RS12050	COG0778	Nitroreductase
GSY53_RS12055	COG0737	Belongs to the 5'-nucleotidase family
GSY53_RS12060	COG0693	protein deglycase activity
GSY53_RS12065	COG2814	Major facilitator Superfamily
GSY53_RS12070	COG4840	Belongs to the UPF0435 family
GSY53_RS12075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSY53_RS12080	COG4980	gas vesicle protein
GSY53_RS12085	COG1295	ribonuclease BN
GSY53_RS12090	COG0477	Major facilitator Superfamily
GSY53_RS12095	COG0387	Pfam Sodium calcium exchanger
GSY53_RS12105	COG0668	transmembrane transport
GSY53_RS12110	COG0535	radical SAM domain protein
GSY53_RS12120	COG0726	polysaccharide deacetylase
GSY53_RS12125	COG2084	Dehydrogenase
GSY53_RS12130	COG0598	Magnesium transport protein CorA
GSY53_RS12135	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GSY53_RS12140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSY53_RS12150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GSY53_RS12155	COG4637	Psort location Cytoplasmic, score
GSY53_RS12165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GSY53_RS12170	COG0022	dehydrogenase e1 component
GSY53_RS12175	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSY53_RS12180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSY53_RS12185	COG3284	Transcriptional regulator
GSY53_RS12195	COG1742	UPF0060 membrane protein
GSY53_RS12220	COG4842	Belongs to the WXG100 family
GSY53_RS12225	COG1486	melibiose metabolic process
GSY53_RS12230	COG1737	Transcriptional regulator
GSY53_RS12235	COG1263	PTS System
GSY53_RS12235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS12240	COG1132	(ABC) transporter
GSY53_RS12245	COG1132	(ABC) transporter
GSY53_RS12250	COG2259	Doxx family
GSY53_RS12255	COG2514	catechol 2,3-dioxygenase activity
GSY53_RS12260	COG4977	sequence-specific DNA binding
GSY53_RS12260	COG1917	Cupin 2, conserved barrel domain protein
GSY53_RS12265	COG2814	Major facilitator Superfamily
GSY53_RS12270	COG1082	Xylose isomerase domain protein TIM barrel
GSY53_RS12275	COG0673	inositol 2-dehydrogenase activity
GSY53_RS12280	COG4585	Histidine kinase
GSY53_RS12285	COG2197	response regulator
GSY53_RS12290	COG1131	(ABC) transporter
GSY53_RS12295	COG0842	Transport permease protein
GSY53_RS12295	COG1511	domain protein
GSY53_RS12300	COG0842	Transport permease protein
GSY53_RS12305	COG1695	Transcriptional regulator
GSY53_RS12310	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GSY53_RS12315	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GSY53_RS12320	COG1309	transcriptional regulator
GSY53_RS12325	COG2814	Major facilitator Superfamily
GSY53_RS12330	COG2318	DinB family
GSY53_RS12335	COG2814	Major facilitator Superfamily
GSY53_RS12340	COG1846	Transcriptional regulator
GSY53_RS12345	COG0392	lysyltransferase activity
GSY53_RS12345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GSY53_RS12350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSY53_RS12355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS12360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSY53_RS12365	COG0384	phenazine biosynthesis protein PhzF
GSY53_RS12370	COG0778	Nitroreductase
GSY53_RS12385	COG1090	epimerase
GSY53_RS12390	COG2137	regulation of response to DNA damage stimulus
GSY53_RS12400	COG2814	Major facilitator Superfamily
GSY53_RS12415	COG3103	Sh3 type 3 domain protein
GSY53_RS12420	COG5658	integral membrane protein
GSY53_RS12425	COG0596	Alpha beta hydrolase
GSY53_RS12430	COG0463	Glycosyl transferase, family 2
GSY53_RS12435	COG4485	Bacterial membrane protein, YfhO
GSY53_RS12440	COG1988	membrane-bound metal-dependent
GSY53_RS12445	COG1194	a g-specific adenine glycosylase
GSY53_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS12470	COG3557	Belongs to the UPF0374 family
GSY53_RS12475	COG1132	(ABC) transporter
GSY53_RS12480	COG4129	membrane
GSY53_RS12485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GSY53_RS12490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GSY53_RS12495	COG0735	belongs to the Fur family
GSY53_RS12605	COG4326	sporulation control protein
GSY53_RS12615	COG5577	PFAM Coat F domain
GSY53_RS12620	COG3340	Belongs to the peptidase S51 family
GSY53_RS12625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GSY53_RS12630	COG0277	FAD linked oxidase domain protein
GSY53_RS12640	COG0753	catalase activity
GSY53_RS12645	COG1116	anion transmembrane transporter activity
GSY53_RS12650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GSY53_RS12655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSY53_RS12660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSY53_RS12670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GSY53_RS12680	COG1476	TRANSCRIPTIONal
GSY53_RS12690	COG3382	B3 4 domain protein
GSY53_RS12695	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GSY53_RS12705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GSY53_RS12710	COG0789	Transcriptional regulator
GSY53_RS12715	COG1664	Polymer-forming cytoskeletal
GSY53_RS12720	COG1664	Polymer-forming cytoskeletal
GSY53_RS12725	COG2766	serine protein kinase
GSY53_RS12730	COG2718	Belongs to the UPF0229 family
GSY53_RS12735	COG1846	Transcriptional regulator
GSY53_RS12740	COG1566	PFAM secretion protein HlyD family protein
GSY53_RS12745	COG2814	Major facilitator Superfamily
GSY53_RS12750	COG0655	NAD(P)H dehydrogenase (quinone) activity
GSY53_RS12770	COG1725	Transcriptional regulator
GSY53_RS12775	COG1131	(ABC) transporter
GSY53_RS12780	COG1131	(ABC) transporter
GSY53_RS12785	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GSY53_RS12790	COG1278	Cold shock
GSY53_RS12795	COG1464	Belongs to the NlpA lipoprotein family
GSY53_RS12800	COG3706	GGDEF domain
GSY53_RS12805	COG1823	symporter activity
GSY53_RS12825	COG5577	PFAM Coat F domain
GSY53_RS12830	COG1525	nuclease
GSY53_RS12830	COG4085	toxin activity
GSY53_RS12830	COG0737	Belongs to the 5'-nucleotidase family
GSY53_RS12835	COG3764	Sortase (surface protein transpeptidase)
GSY53_RS12840	COG0564	pseudouridine synthase activity
GSY53_RS12850	COG0517	IMP dehydrogenase activity
GSY53_RS12855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSY53_RS12860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSY53_RS12860	COG3153	acetyltransferase
GSY53_RS12865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GSY53_RS12870	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GSY53_RS12875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GSY53_RS12880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GSY53_RS12885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GSY53_RS12890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSY53_RS12895	COG2203	Gaf domain
GSY53_RS12895	COG4585	Histidine kinase
GSY53_RS12900	COG2197	response regulator
GSY53_RS12905	COG0431	NADPH-dependent FMN reductase
GSY53_RS12920	COG0791	NLP P60 protein
GSY53_RS12920	COG1388	LysM domain
GSY53_RS12925	COG1959	2 iron, 2 sulfur cluster binding
GSY53_RS12930	COG0668	transmembrane transport
GSY53_RS12935	COG2719	SpoVR family
GSY53_RS12940	COG1785	Belongs to the alkaline phosphatase family
GSY53_RS12945	COG0791	NLP P60 protein
GSY53_RS12945	COG1388	LysM domain
GSY53_RS12950	COG0583	DNA-binding transcription factor activity
GSY53_RS12955	COG0372	Belongs to the citrate synthase family
GSY53_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS12965	COG0531	amino acid
GSY53_RS12970	COG0733	neurotransmitter:sodium symporter activity
GSY53_RS12975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY53_RS12980	COG0456	acetyltransferase
GSY53_RS12995	COG1595	DNA-templated transcription, initiation
GSY53_RS13000	COG0667	Aldo Keto reductase
GSY53_RS13005	COG0204	Acyl-transferase
GSY53_RS13010	COG1253	flavin adenine dinucleotide binding
GSY53_RS13015	COG0789	Transcriptional regulator
GSY53_RS13020	COG0436	Aminotransferase
GSY53_RS13025	COG1253	flavin adenine dinucleotide binding
GSY53_RS13030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GSY53_RS13035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GSY53_RS13040	COG0584	glycerophosphoryl diester phosphodiesterase
GSY53_RS13050	COG0668	transmembrane transport
GSY53_RS13055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GSY53_RS13060	COG0726	polysaccharide deacetylase
GSY53_RS13065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSY53_RS13070	COG1757	Na H antiporter
GSY53_RS13075	COG0589	response to stress
GSY53_RS13085	COG1132	(ABC) transporter
GSY53_RS13090	COG1132	(ABC) transporter
GSY53_RS13095	COG0702	epimerase
GSY53_RS13115	COG0189	ligase activity
GSY53_RS13120	COG0189	ligase activity
GSY53_RS13125	COG4399	Belongs to the UPF0754 family
GSY53_RS13130	COG3679	Belongs to the UPF0342 family
GSY53_RS13135	COG4335	DNA alkylation repair
GSY53_RS13140	COG0561	phosphatase activity
GSY53_RS13145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GSY53_RS13150	COG0475	glutathione-regulated potassium exporter activity
GSY53_RS13155	COG0490	domain, Protein
GSY53_RS13165	COG1024	Enoyl-CoA hydratase
GSY53_RS13175	COG4152	abc transporter atp-binding protein
GSY53_RS13180	COG1668	transmembrane transport
GSY53_RS13185	COG0420	3'-5' exonuclease activity
GSY53_RS13190	COG4717	serine-type aminopeptidase activity
GSY53_RS13195	COG3481	metal-dependent phosphohydrolase, HD sub domain
GSY53_RS13205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSY53_RS13235	COG1846	Transcriptional regulator
GSY53_RS13240	COG4980	gas vesicle protein
GSY53_RS13255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GSY53_RS13260	COG0537	adenosine 5'-monophosphoramidase activity
GSY53_RS13265	COG1131	(ABC) transporter
GSY53_RS13270	COG4473	ABC transporter
GSY53_RS13280	COG1473	amidohydrolase
GSY53_RS13285	COG3069	C4-dicarboxylate transmembrane transporter activity
GSY53_RS13295	COG2329	Antibiotic biosynthesis monooxygenase
GSY53_RS13300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSY53_RS13305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GSY53_RS13320	COG1309	transcriptional regulator
GSY53_RS13325	COG1511	domain protein
GSY53_RS13330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSY53_RS13335	COG4377	Putative membrane peptidase family (DUF2324)
GSY53_RS13345	COG1363	Peptidase, m42
GSY53_RS13350	COG4405	Protein conserved in bacteria
GSY53_RS13355	COG1301	dicarboxylic acid transport
GSY53_RS13365	COG1234	tRNA 3'-trailer cleavage
GSY53_RS13370	COG0095	Lipoate-protein ligase
GSY53_RS13375	COG0702	epimerase
GSY53_RS13380	COG0318	PFAM AMP-dependent synthetase and ligase
GSY53_RS13390	COG0501	Belongs to the peptidase M48B family
GSY53_RS13400	COG0456	acetyltransferase
GSY53_RS13405	COG0604	alcohol dehydrogenase
GSY53_RS13410	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GSY53_RS13415	COG0406	alpha-ribazole phosphatase activity
GSY53_RS13420	COG0183	Belongs to the thiolase family
GSY53_RS13425	COG0318	PFAM AMP-dependent synthetase and ligase
GSY53_RS13430	COG1268	BioY protein
GSY53_RS13435	COG0840	transmembrane signaling receptor activity
GSY53_RS13440	COG0723	plastoquinol--plastocyanin reductase activity
GSY53_RS13440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSY53_RS13445	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS13455	COG4903	ComK protein
GSY53_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS13470	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY53_RS13485	COG0398	Pfam SNARE associated Golgi protein
GSY53_RS13490	COG0681	Belongs to the peptidase S26 family
GSY53_RS13495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSY53_RS13500	COG1846	Transcriptional regulator
GSY53_RS13505	COG0738	Major facilitator superfamily
GSY53_RS13510	COG0673	inositol 2-dehydrogenase activity
GSY53_RS13515	COG0561	phosphatase activity
GSY53_RS13520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GSY53_RS13525	COG1609	Transcriptional regulator
GSY53_RS13530	COG3180	Ammonia monooxygenase
GSY53_RS13535	COG2814	Major facilitator Superfamily
GSY53_RS13535	COG0477	Major facilitator Superfamily
GSY53_RS13550	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GSY53_RS13555	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GSY53_RS13560	COG1074	ATP-dependent DNA helicase activity
GSY53_RS13565	COG0420	3'-5' exonuclease activity
GSY53_RS13570	COG0419	ATPase involved in DNA repair
GSY53_RS13575	COG1403	HNH endonuclease
GSY53_RS13615	COG5337	Spore coat protein CotH
GSY53_RS13620	COG0179	Fumarylacetoacetate (FAA) hydrolase
GSY53_RS13630	COG1404	Belongs to the peptidase S8 family
GSY53_RS13640	COG0367	asparagine synthase
GSY53_RS13645	COG2318	DinB family
GSY53_RS13650	COG1562	ergosterol biosynthetic process
GSY53_RS13655	COG0534	Mate efflux family protein
GSY53_RS13660	COG1917	Cupin 2, conserved barrel domain protein
GSY53_RS13660	COG2207	Transcriptional regulator
GSY53_RS13665	COG1609	Transcriptional regulator
GSY53_RS13670	COG0673	inositol 2-dehydrogenase activity
GSY53_RS13675	COG2318	DinB family
GSY53_RS13680	COG1279	arginine transmembrane transporter activity
GSY53_RS13685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSY53_RS13690	COG1357	PFAM Pentapeptide repeats (8 copies)
GSY53_RS13695	COG2267	carboxylic ester hydrolase activity
GSY53_RS13700	COG0529	Catalyzes the synthesis of activated sulfate
GSY53_RS13705	COG2046	Belongs to the sulfate adenylyltransferase family
GSY53_RS13710	COG0175	sulfate reduction
GSY53_RS13715	COG2045	Belongs to the ComB family
GSY53_RS13720	COG1809	phosphosulfolactate synthase activity
GSY53_RS13725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSY53_RS13730	COG4948	Mandelate Racemase Muconate Lactonizing
GSY53_RS13735	COG2814	Major facilitator Superfamily
GSY53_RS13740	COG0454	-acetyltransferase
GSY53_RS13745	COG2153	protein acetylation
GSY53_RS13750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GSY53_RS13750	COG0646	methionine synthase
GSY53_RS13755	COG1666	GTP binding
GSY53_RS13760	COG2996	Protein conserved in bacteria
GSY53_RS13780	COG1695	Transcriptional regulator
GSY53_RS13795	COG3227	Zinc metalloprotease (Elastase)
GSY53_RS13800	COG1307	EDD domain protein, DegV family
GSY53_RS13805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSY53_RS13820	COG0561	phosphatase activity
GSY53_RS13825	COG1073	alpha beta
GSY53_RS13830	COG2151	metal-sulfur cluster biosynthetic enzyme
GSY53_RS13840	COG0277	FAD linked oxidase domain protein
GSY53_RS13845	COG2271	Major facilitator Superfamily
GSY53_RS13850	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GSY53_RS13865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GSY53_RS13870	COG0505	Belongs to the CarA family
GSY53_RS13875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GSY53_RS13880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSY53_RS13895	COG2267	carboxylic ester hydrolase activity
GSY53_RS13905	COG1744	ABC transporter substrate-binding protein PnrA-like
GSY53_RS13920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSY53_RS13925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GSY53_RS13930	COG5504	Zn-dependent protease
GSY53_RS13935	COG0444	Belongs to the ABC transporter superfamily
GSY53_RS13940	COG4608	Belongs to the ABC transporter superfamily
GSY53_RS13950	COG0601	transmembrane transport
GSY53_RS13955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSY53_RS13965	COG0180	Tryptophanyl-tRNA synthetase
GSY53_RS13970	COG4166	transmembrane transport
GSY53_RS13975	COG0601	transmembrane transport
GSY53_RS13980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSY53_RS13985	COG0444	Belongs to the ABC transporter superfamily
GSY53_RS13990	COG4608	Belongs to the ABC transporter superfamily
GSY53_RS13995	COG2814	Major facilitator Superfamily
GSY53_RS14000	COG0456	acetyltransferase
GSY53_RS14005	COG1393	Belongs to the ArsC family
GSY53_RS14010	COG0861	Integral membrane protein TerC family
GSY53_RS14020	COG4862	establishment of competence for transformation
GSY53_RS14030	COG4469	Competence protein
GSY53_RS14035	COG1164	Oligoendopeptidase f
GSY53_RS14050	COG2346	COG2346, Truncated hemoglobins
GSY53_RS14055	COG0741	lytic transglycosylase activity
GSY53_RS14060	COG4116	CYTH
GSY53_RS14070	COG2357	RelA SpoT domain protein
GSY53_RS14075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GSY53_RS14080	COG0564	pseudouridine synthase activity
GSY53_RS14085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GSY53_RS14090	COG0475	glutathione-regulated potassium exporter activity
GSY53_RS14090	COG0569	domain protein
GSY53_RS14095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GSY53_RS14100	COG0352	thiamine-phosphate diphosphorylase activity
GSY53_RS14105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSY53_RS14110	COG2104	thiamine diphosphate biosynthetic process
GSY53_RS14115	COG2022	thiamine diphosphate biosynthetic process
GSY53_RS14120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GSY53_RS14125	COG0351	phosphomethylpyrimidine kinase
GSY53_RS14130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GSY53_RS14185	COG0210	DNA helicase
GSY53_RS14195	COG2153	protein acetylation
GSY53_RS14200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GSY53_RS14205	COG2382	esterase
GSY53_RS14210	COG0626	cystathionine gamma-synthase activity
GSY53_RS14215	COG0626	cystathionine gamma-synthase activity
GSY53_RS14220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY53_RS14225	COG5505	Protein of unknown function (DUF819)
GSY53_RS14250	COG5444	nuclease activity
GSY53_RS14295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GSY53_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS14310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY53_RS14310	COG3711	transcriptional antiterminator
GSY53_RS14315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY53_RS14315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSY53_RS14315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSY53_RS14320	COG1482	cell wall glycoprotein biosynthetic process
GSY53_RS14330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY53_RS14340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GSY53_RS14355	COG0109	protoheme IX farnesyltransferase activity
GSY53_RS14365	COG0726	polysaccharide deacetylase
GSY53_RS14380	COG5504	Zn-dependent protease
GSY53_RS14385	COG2205	protein histidine kinase activity
GSY53_RS14395	COG3383	formate dehydrogenase (NAD+) activity
GSY53_RS14400	COG2427	Protein of unknown function (DUF1641)
GSY53_RS14410	COG1051	belongs to the nudix hydrolase family
GSY53_RS14420	COG2124	cytochrome p450
GSY53_RS14425	COG1819	glycosyl
GSY53_RS14435	COG1587	Uroporphyrinogen-III synthase
GSY53_RS14440	COG0390	transport system, permease component
GSY53_RS14445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GSY53_RS14450	COG0697	spore germination
GSY53_RS14455	COG4297	protein containing double-stranded beta helix domain
GSY53_RS14465	COG1252	NADH dehydrogenase
GSY53_RS14470	COG1904	glucuronate isomerase
GSY53_RS14475	COG2211	Major facilitator Superfamily
GSY53_RS14480	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GSY53_RS14485	COG1063	alcohol dehydrogenase
GSY53_RS14490	COG1312	Catalyzes the dehydration of D-mannonate
GSY53_RS14495	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS14500	COG2271	Major facilitator Superfamily
GSY53_RS14505	COG1609	Transcriptional regulator
GSY53_RS14510	COG0246	Mannitol dehydrogenase
GSY53_RS14515	COG2721	sulfolactate sulfo-lyase activity
GSY53_RS14520	COG0730	response to heat
GSY53_RS14525	COG2318	DinB family
GSY53_RS14530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GSY53_RS14535	COG0457	Tetratricopeptide repeat
GSY53_RS14545	COG2350	Protein conserved in bacteria
GSY53_RS14550	COG5632	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS14550	COG1388	LysM domain
GSY53_RS14550	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS14560	COG4195	phage-related replication protein
GSY53_RS14565	COG3546	catalase activity
GSY53_RS14570	COG2856	Zn peptidase
GSY53_RS14575	COG1396	sequence-specific DNA binding
GSY53_RS14585	COG1522	sequence-specific DNA binding
GSY53_RS14590	COG1484	DNA-dependent DNA replication
GSY53_RS14610	COG1595	DNA-templated transcription, initiation
GSY53_RS14615	COG3728	DNA packaging
GSY53_RS14615	COG5484	DNA packaging
GSY53_RS14620	COG1783	phage Terminase large subunit
GSY53_RS14625	COG5518	Phage portal protein
GSY53_RS14630	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GSY53_RS14635	COG4653	Phage capsid family
GSY53_RS14685	COG3953	SLT domain
GSY53_RS14685	COG5412	phage tail tape measure protein
GSY53_RS14690	COG1652	LysM domain
GSY53_RS14695	COG4193	domain, Protein
GSY53_RS14705	COG3628	GPW Gp25 family protein
GSY53_RS14710	COG3299	homolog of phage Mu protein gp47
GSY53_RS14715	COG3778	Protein conserved in bacteria
GSY53_RS14755	COG5632	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS14755	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS14775	COG0306	phosphate transporter
GSY53_RS14780	COG1392	Phosphate transport regulator
GSY53_RS14785	COG0531	amino acid
GSY53_RS14790	COG0346	lactoylglutathione lyase activity
GSY53_RS14795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GSY53_RS14800	COG0463	Glycosyl transferase, family 2
GSY53_RS14805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSY53_RS14810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GSY53_RS14815	COG2362	D-Aminopeptidase
GSY53_RS14820	COG0601	transmembrane transport
GSY53_RS14825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSY53_RS14830	COG0444	Belongs to the ABC transporter superfamily
GSY53_RS14835	COG4166	transmembrane transport
GSY53_RS14840	COG1619	proteins homologs of microcin C7 resistance protein MccF
GSY53_RS14845	COG4948	Mandelate Racemase Muconate Lactonizing
GSY53_RS14850	COG0791	NLP P60 protein
GSY53_RS14855	COG4608	Belongs to the ABC transporter superfamily
GSY53_RS14860	COG2706	6-phosphogluconolactonase activity
GSY53_RS14865	COG1834	amidinotransferase
GSY53_RS14870	COG1607	acyl-coa hydrolase
GSY53_RS14875	COG1017	nitric oxide dioxygenase activity
GSY53_RS14875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSY53_RS14885	COG2323	membrane
GSY53_RS14890	COG2318	DinB family
GSY53_RS14895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY53_RS14900	COG2076	Multidrug Resistance protein
GSY53_RS14905	COG2076	Multidrug Resistance protein
GSY53_RS14910	COG0788	formyltetrahydrofolate deformylase activity
GSY53_RS14915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GSY53_RS14920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GSY53_RS14925	COG1764	response to oxidative stress
GSY53_RS14930	COG1846	Transcriptional regulator
GSY53_RS14935	COG1764	response to oxidative stress
GSY53_RS14945	COG0590	tRNA wobble adenosine to inosine editing
GSY53_RS14950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GSY53_RS14955	COG1404	Belongs to the peptidase S8 family
GSY53_RS14960	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY53_RS14965	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GSY53_RS14970	COG1122	ATPase activity
GSY53_RS14975	COG4721	ABC-type cobalt transport system, permease component
GSY53_RS14985	COG0745	RESPONSE REGULATOR receiver
GSY53_RS14990	COG3850	Histidine kinase
GSY53_RS14990	COG5002	protein histidine kinase activity
GSY53_RS14995	COG3212	peptidase
GSY53_RS15000	COG3212	peptidase
GSY53_RS15010	COG2239	Acts as a magnesium transporter
GSY53_RS15015	COG0789	Transcriptional regulator
GSY53_RS15030	COG1846	Transcriptional regulator
GSY53_RS15035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GSY53_RS15040	COG0726	polysaccharide deacetylase
GSY53_RS15045	COG1408	metallophosphoesterase
GSY53_RS15055	COG0463	Glycosyl transferase, family 2
GSY53_RS15060	COG1793	dna ligase
GSY53_RS15060	COG3285	dna ligase
GSY53_RS15065	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GSY53_RS15070	COG5001	Diguanylate cyclase
GSY53_RS15070	COG3300	MHYT domain
GSY53_RS15075	COG0586	Pfam SNARE associated Golgi protein
GSY53_RS15080	COG0861	Integral membrane protein TerC family
GSY53_RS15085	COG1191	sigma factor activity
GSY53_RS15105	COG0501	Belongs to the peptidase M48B family
GSY53_RS15110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GSY53_RS15125	COG3594	Acyltransferase
GSY53_RS15130	COG5002	protein histidine kinase activity
GSY53_RS15135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GSY53_RS15145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GSY53_RS15150	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GSY53_RS15155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSY53_RS15160	COG0436	Aminotransferase
GSY53_RS15165	COG1850	ribulose-bisphosphate carboxylase activity
GSY53_RS15170	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GSY53_RS15175	COG0235	Class ii aldolase
GSY53_RS15180	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GSY53_RS15185	COG3339	Conserved Protein
GSY53_RS15200	COG3852	Histidine kinase
GSY53_RS15205	COG1846	Transcriptional regulator
GSY53_RS15210	COG1360	Flagellar Motor Protein
GSY53_RS15215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GSY53_RS15220	COG0542	response to heat
GSY53_RS15225	COG3949	Membrane
GSY53_RS15230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GSY53_RS15235	COG0720	synthase
GSY53_RS15240	COG0602	queuosine metabolic process
GSY53_RS15245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GSY53_RS15250	COG1733	regulation of RNA biosynthetic process
GSY53_RS15255	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS15260	COG4641	Protein conserved in bacteria
GSY53_RS15260	COG1388	LysM domain
GSY53_RS15265	COG1388	LysM domain
GSY53_RS15280	COG4873	Protein conserved in bacteria
GSY53_RS15290	COG3773	Cell wall hydrolase
GSY53_RS15295	COG2244	polysaccharide biosynthetic process
GSY53_RS15300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS15305	COG2217	Heavy metal translocating P-type atpase
GSY53_RS15315	COG0006	proline dipeptidase activity
GSY53_RS15320	COG1609	Transcriptional regulator
GSY53_RS15325	COG3711	transcriptional antiterminator
GSY53_RS15330	COG2190	(PTS) system
GSY53_RS15330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSY53_RS15330	COG1263	PTS System
GSY53_RS15335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY53_RS15340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSY53_RS15350	COG1533	DNA photolyase activity
GSY53_RS15355	COG0456	acetyltransferase
GSY53_RS15360	COG0840	transmembrane signaling receptor activity
GSY53_RS15365	COG2084	Dehydrogenase
GSY53_RS15370	COG2340	Cysteine-rich secretory protein family
GSY53_RS15375	COG0768	penicillin binding
GSY53_RS15380	COG4191	Histidine kinase
GSY53_RS15385	COG0436	Aminotransferase
GSY53_RS15395	COG0835	chemotaxis
GSY53_RS15395	COG0784	Response regulator, receiver
GSY53_RS15405	COG2814	Major facilitator Superfamily
GSY53_RS15410	COG1376	ErfK ybiS ycfS ynhG family protein
GSY53_RS15415	COG1408	metallophosphoesterase
GSY53_RS15420	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS15425	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS15430	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS15440	COG2200	EAL domain
GSY53_RS15450	COG4703	Protein of unknown function (DUF1797)
GSY53_RS15455	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GSY53_RS15465	COG0517	IMP dehydrogenase activity
GSY53_RS15470	COG0583	DNA-binding transcription factor activity
GSY53_RS15475	COG0716	FMN binding
GSY53_RS15485	COG0716	FMN binding
GSY53_RS15490	COG2171	N-acyltransferase activity
GSY53_RS15495	COG1473	amidohydrolase
GSY53_RS15505	COG0668	transmembrane transport
GSY53_RS15510	COG0450	alkyl hydroperoxide reductase
GSY53_RS15515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS15530	COG0746	molybdenum cofactor guanylyltransferase activity
GSY53_RS15535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GSY53_RS15540	COG0303	'Molybdopterin
GSY53_RS15545	COG1763	Mo-molybdopterin cofactor biosynthetic process
GSY53_RS15550	COG0314	molybdopterin synthase activity
GSY53_RS15555	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GSY53_RS15560	COG1132	(ABC) transporter
GSY53_RS15565	COG1132	(ABC) transporter
GSY53_RS15575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSY53_RS15580	COG1136	(ABC) transporter
GSY53_RS15585	COG0577	efflux transmembrane transporter activity
GSY53_RS15590	COG1349	DNA-binding transcription factor activity
GSY53_RS15595	COG1105	Belongs to the carbohydrate kinase PfkB family
GSY53_RS15600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSY53_RS15600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSY53_RS15600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSY53_RS15605	COG0681	Belongs to the peptidase S26 family
GSY53_RS15615	COG0488	(ABC) transporter
GSY53_RS15620	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GSY53_RS15625	COG2309	aminopeptidase activity
GSY53_RS15635	COG1077	Cell shape determining protein MreB Mrl
GSY53_RS15640	COG2002	toxin-antitoxin pair type II binding
GSY53_RS15645	COG3852	Histidine kinase
GSY53_RS15650	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GSY53_RS15650	COG2105	PFAM AIG2 family protein
GSY53_RS15655	COG0569	domain protein
GSY53_RS15660	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GSY53_RS15665	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GSY53_RS15675	COG0561	phosphatase activity
GSY53_RS15680	COG0242	peptide deformylase activity
GSY53_RS15690	COG0497	DNA recombination
GSY53_RS15695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GSY53_RS15700	COG0022	dehydrogenase e1 component
GSY53_RS15705	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSY53_RS15710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSY53_RS15715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS15725	COG1982	Orn Lys Arg decarboxylase major
GSY53_RS15730	COG4476	Belongs to the UPF0223 family
GSY53_RS15735	COG4493	Belongs to the UPF0637 family
GSY53_RS15745	COG0483	inositol monophosphate 1-phosphatase activity
GSY53_RS15755	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GSY53_RS15805	COG4896	Protein conserved in bacteria
GSY53_RS15815	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GSY53_RS15820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GSY53_RS15825	COG2066	Belongs to the glutaminase family
GSY53_RS15830	COG4838	Belongs to the UPF0358 family
GSY53_RS15835	COG0772	Belongs to the SEDS family
GSY53_RS15840	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GSY53_RS15845	COG1612	heme a metabolic process
GSY53_RS15850	COG0109	protoheme IX farnesyltransferase activity
GSY53_RS15855	COG2010	Cytochrome c
GSY53_RS15855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GSY53_RS15860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GSY53_RS15865	COG1845	cytochrome c oxidase, subunit III
GSY53_RS15870	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GSY53_RS15875	COG3336	cytochrome c oxidase
GSY53_RS15885	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GSY53_RS15890	COG2340	Cysteine-rich secretory protein family
GSY53_RS15905	COG3679	Belongs to the UPF0342 family
GSY53_RS15910	COG4471	UPF0298 protein
GSY53_RS15915	COG0742	ribosomal rna small subunit methyltransferase
GSY53_RS15920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GSY53_RS15925	COG3314	Sporulation integral membrane protein YlbJ
GSY53_RS15930	COG1752	Esterase of the alpha-beta hydrolase superfamily
GSY53_RS15935	COG3480	Lon protease (S16) C-terminal proteolytic domain
GSY53_RS15940	COG1323	Belongs to the UPF0348 family
GSY53_RS15950	COG1399	metal-binding, possibly nucleic acid-binding protein
GSY53_RS15955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GSY53_RS15965	COG0454	-acetyltransferase
GSY53_RS15970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GSY53_RS15975	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GSY53_RS15980	COG2001	Belongs to the MraZ family
GSY53_RS15985	COG0275	rRNA processing
GSY53_RS15990	COG4839	cell division protein FtsL
GSY53_RS16000	COG0768	penicillin binding
GSY53_RS16005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GSY53_RS16010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSY53_RS16015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GSY53_RS16020	COG0772	Belongs to the SEDS family
GSY53_RS16025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GSY53_RS16030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GSY53_RS16035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GSY53_RS16040	COG3879	Bacterial protein of unknown function (DUF881)
GSY53_RS16045	COG3879	Bacterial protein of unknown function (DUF881)
GSY53_RS16050	COG3856	small basic protein
GSY53_RS16055	COG0849	cell division
GSY53_RS16060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GSY53_RS16065	COG1404	Belongs to the peptidase S8 family
GSY53_RS16065	COG4412	M6 family metalloprotease domain protein
GSY53_RS16075	COG1191	sigma factor activity
GSY53_RS16080	COG1191	sigma factor activity
GSY53_RS16085	COG1119	ATPase activity
GSY53_RS16090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSY53_RS16095	COG1873	PFAM PRC-barrel domain
GSY53_RS16105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GSY53_RS16110	COG1799	cell septum assembly
GSY53_RS16115	COG0762	integral membrane protein
GSY53_RS16120	COG2302	S4 RNA-binding domain
GSY53_RS16125	COG3599	regulation of cell shape
GSY53_RS16130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GSY53_RS16135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GSY53_RS16140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GSY53_RS16145	COG0564	pseudouridine synthase activity
GSY53_RS16150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GSY53_RS16155	COG2233	PERMEase
GSY53_RS16160	COG0540	Belongs to the ATCase OTCase family
GSY53_RS16165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GSY53_RS16170	COG0505	Belongs to the CarA family
GSY53_RS16175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GSY53_RS16180	COG0543	2 iron, 2 sulfur cluster binding
GSY53_RS16185	COG0167	dihydroorotate dehydrogenase activity
GSY53_RS16190	COG0284	orotidine-5'-phosphate decarboxylase activity
GSY53_RS16195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GSY53_RS16200	COG0175	sulfate reduction
GSY53_RS16205	COG0306	phosphate transporter
GSY53_RS16210	COG2046	Belongs to the sulfate adenylyltransferase family
GSY53_RS16215	COG0529	Catalyzes the synthesis of activated sulfate
GSY53_RS16220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSY53_RS16225	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GSY53_RS16230	COG1648	precorrin-2 dehydrogenase activity
GSY53_RS16240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GSY53_RS16245	COG1561	YicC-like family, N-terminal region
GSY53_RS16250	COG2052	Domain of unknown function (DUF370)
GSY53_RS16255	COG0194	GDP metabolic process
GSY53_RS16260	COG1758	RNA polymerase activity
GSY53_RS16265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GSY53_RS16270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GSY53_RS16275	COG0242	peptide deformylase activity
GSY53_RS16280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSY53_RS16285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSY53_RS16285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GSY53_RS16290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GSY53_RS16295	COG0631	protein serine/threonine phosphatase activity
GSY53_RS16300	COG0515	serine threonine protein kinase
GSY53_RS16300	COG2815	serine threonine protein kinase
GSY53_RS16305	COG1162	GTPase activity
GSY53_RS16310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GSY53_RS16315	COG1564	THIamine pyrophosphokinase
GSY53_RS16325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GSY53_RS16330	COG1302	Protein conserved in bacteria
GSY53_RS16335	COG1461	Dihydroxyacetone kinase
GSY53_RS16340	COG1760	l-serine dehydratase
GSY53_RS16345	COG1760	l-serine dehydratase
GSY53_RS16350	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GSY53_RS16355	COG1349	DNA-binding transcription factor activity
GSY53_RS16355	COG2050	protein possibly involved in aromatic compounds catabolism
GSY53_RS16360	COG0416	fatty acid biosynthetic process
GSY53_RS16365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GSY53_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS16375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSY53_RS16380	COG0571	ribonuclease III activity
GSY53_RS16385	COG1196	nuclear chromosome segregation
GSY53_RS16390	COG0552	protein localization to endoplasmic reticulum
GSY53_RS16400	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GSY53_RS16405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GSY53_RS16410	COG0228	four-way junction DNA binding
GSY53_RS16415	COG1837	Belongs to the UPF0109 family
GSY53_RS16425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GSY53_RS16430	COG0336	Belongs to the RNA methyltransferase TrmD family
GSY53_RS16435	COG0335	large ribosomal subunit rRNA binding
GSY53_RS16440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GSY53_RS16445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GSY53_RS16455	COG2257	FlhB HrpN YscU SpaS Family
GSY53_RS16460	COG0045	succinate-CoA ligase (ADP-forming) activity
GSY53_RS16465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GSY53_RS16470	COG0758	DNA mediated transformation
GSY53_RS16475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GSY53_RS16480	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GSY53_RS16485	COG4974	Belongs to the 'phage' integrase family
GSY53_RS16490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GSY53_RS16495	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GSY53_RS16500	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GSY53_RS16505	COG1815	bacterial-type flagellum-dependent cell motility
GSY53_RS16510	COG1558	bacterial-type flagellum-dependent cell motility
GSY53_RS16515	COG1677	Flagellar hook-basal body complex protein FliE
GSY53_RS16520	COG1766	The M ring may be actively involved in energy transduction
GSY53_RS16525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GSY53_RS16530	COG1317	bacterial-type flagellum organization
GSY53_RS16535	COG1157	protein secretion by the type III secretion system
GSY53_RS16540	COG2882	bacterial-type flagellum organization
GSY53_RS16545	COG3334	PFAM MgtE intracellular
GSY53_RS16550	COG3144	bacterial-type flagellum assembly
GSY53_RS16555	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GSY53_RS16560	COG4786	Flagellar basal body rod
GSY53_RS16565	COG1582	Flagellar protein (FlbD)
GSY53_RS16570	COG1580	Controls the rotational direction of flagella during chemotaxis
GSY53_RS16575	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GSY53_RS16580	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GSY53_RS16580	COG1776	CheC inhibitor of MCP methylation
GSY53_RS16585	COG2201	protein-glutamate methylesterase activity
GSY53_RS16590	COG3190	flagellar
GSY53_RS16595	COG1338	Plays a role in the flagellum-specific transport system
GSY53_RS16600	COG1987	bacterial-type flagellum assembly
GSY53_RS16605	COG1684	flagellar biosynthetic protein fliR
GSY53_RS16610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GSY53_RS16615	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GSY53_RS16620	COG1419	protein localization to endoplasmic reticulum
GSY53_RS16625	COG0455	bacterial-type flagellum organization
GSY53_RS16630	COG2201	protein-glutamate methylesterase activity
GSY53_RS16635	COG0643	Histidine kinase
GSY53_RS16635	COG2198	Histidine kinase
GSY53_RS16640	COG0835	chemotaxis
GSY53_RS16645	COG1776	CheC inhibitor of MCP methylation
GSY53_RS16650	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GSY53_RS16655	COG1191	sigma factor activity
GSY53_RS16665	COG0052	Belongs to the universal ribosomal protein uS2 family
GSY53_RS16670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GSY53_RS16675	COG0528	UMP kinase activity
GSY53_RS16680	COG0233	cytoplasmic translational termination
GSY53_RS16685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GSY53_RS16690	COG4589	Belongs to the CDS family
GSY53_RS16695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GSY53_RS16700	COG0750	zinc metalloprotease
GSY53_RS16705	COG0442	prolyl-tRNA aminoacylation
GSY53_RS16710	COG2176	DNA-directed DNA polymerase activity
GSY53_RS16715	COG0779	Required for maturation of 30S ribosomal subunits
GSY53_RS16720	COG0195	Participates in both transcription termination and antitermination
GSY53_RS16725	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GSY53_RS16730	COG1358	cellular component organization or biogenesis
GSY53_RS16735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GSY53_RS16740	COG1550	Protein conserved in bacteria
GSY53_RS16745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GSY53_RS16750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GSY53_RS16755	COG0196	riboflavin kinase activity
GSY53_RS16760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GSY53_RS16765	COG1185	polyribonucleotide nucleotidyltransferase activity
GSY53_RS16770	COG0726	polysaccharide deacetylase
GSY53_RS16775	COG0612	Peptidase, M16
GSY53_RS16780	COG1873	PFAM PRC-barrel domain
GSY53_RS16785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSY53_RS16790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GSY53_RS16795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GSY53_RS16800	COG0527	aspartate kinase activity
GSY53_RS16805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSY53_RS16810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GSY53_RS16815	COG0740	serine-type endopeptidase activity
GSY53_RS16825	COG4980	gas vesicle protein
GSY53_RS16825	COG1674	ftsk spoiiie
GSY53_RS16830	COG2188	Transcriptional regulator
GSY53_RS16835	COG2814	Major facilitator Superfamily
GSY53_RS16840	COG0612	Peptidase, M16
GSY53_RS16845	COG0612	Peptidase, M16
GSY53_RS16850	COG0300	oxidoreductase activity
GSY53_RS16865	COG1426	Protein conserved in bacteria
GSY53_RS16870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GSY53_RS16875	COG1546	Belongs to the CinA family
GSY53_RS16875	COG1058	Belongs to the CinA family
GSY53_RS16880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GSY53_RS16885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GSY53_RS16890	COG1418	mRNA catabolic process
GSY53_RS16895	COG1692	metallophosphoesterase
GSY53_RS16900	COG2359	stage V sporulation protein S
GSY53_RS16905	COG1063	alcohol dehydrogenase
GSY53_RS16910	COG0156	8-amino-7-oxononanoate synthase activity
GSY53_RS16915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSY53_RS16920	COG4550	Control of competence regulator ComK, YlbF/YmcA
GSY53_RS16930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GSY53_RS16935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GSY53_RS16950	COG3226	Transcriptional regulator
GSY53_RS16955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSY53_RS16965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GSY53_RS16970	COG3321	synthase
GSY53_RS16975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GSY53_RS16975	COG2070	2-Nitropropane dioxygenase
GSY53_RS16980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSY53_RS16985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GSY53_RS16990	COG3425	synthase
GSY53_RS16995	COG1024	Enoyl-CoA hydratase
GSY53_RS17000	COG1024	Enoyl-CoA hydratase
GSY53_RS17005	COG3321	synthase
GSY53_RS17005	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS17005	COG0318	PFAM AMP-dependent synthetase and ligase
GSY53_RS17005	COG0300	oxidoreductase activity
GSY53_RS17005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS17010	COG4221	oxidoreductase activity
GSY53_RS17010	COG3321	synthase
GSY53_RS17010	COG0300	oxidoreductase activity
GSY53_RS17010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSY53_RS17015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS17015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSY53_RS17015	COG3321	synthase
GSY53_RS17015	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS17015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSY53_RS17020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS17020	COG3321	synthase
GSY53_RS17020	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS17020	COG4221	oxidoreductase activity
GSY53_RS17025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GSY53_RS17025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSY53_RS17025	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GSY53_RS17025	COG3321	synthase
GSY53_RS17030	COG2124	cytochrome p450
GSY53_RS17040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSY53_RS17045	COG1404	Belongs to the peptidase S8 family
GSY53_RS17055	COG4195	phage-related replication protein
GSY53_RS17060	COG1764	response to oxidative stress
GSY53_RS17065	COG2076	Multidrug Resistance protein
GSY53_RS17070	COG2076	Multidrug Resistance protein
GSY53_RS17085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GSY53_RS17090	COG1923	regulation of RNA biosynthetic process
GSY53_RS17105	COG1780	Probably involved in ribonucleotide reductase function
GSY53_RS17110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSY53_RS17115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSY53_RS17120	COG4112	unkown
GSY53_RS17125	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS17130	COG0464	growth
GSY53_RS17135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GSY53_RS17140	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GSY53_RS17145	COG0789	Transcriptional regulator
GSY53_RS17150	COG0174	glutamine synthetase
GSY53_RS17165	COG1396	sequence-specific DNA binding
GSY53_RS17325	COG3953	SLT domain
GSY53_RS17325	COG5280	Phage tail tape measure protein TP901
GSY53_RS17335	COG1705	Flagellar rod assembly protein muramidase FlgJ
GSY53_RS17340	COG5434	Belongs to the glycosyl hydrolase 28 family
GSY53_RS17365	COG4824	toxin secretion phage lysis holin
GSY53_RS17370	COG5632	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS17370	COG1388	LysM domain
GSY53_RS17370	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS17380	COG5444	nuclease activity
GSY53_RS17385	COG0457	Tetratricopeptide repeat
GSY53_RS17405	COG4282	regulation of fungal-type cell wall biogenesis
GSY53_RS17415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY53_RS17445	COG0135	phosphoribosylanthranilate isomerase activity
GSY53_RS17450	COG2211	Major facilitator Superfamily
GSY53_RS17455	COG3507	Belongs to the glycosyl hydrolase 43 family
GSY53_RS17460	COG1940	carbohydrate kinase activity
GSY53_RS17465	COG2115	Belongs to the xylose isomerase family
GSY53_RS17470	COG1070	Carbohydrate kinase
GSY53_RS17480	COG1525	nuclease
GSY53_RS17485	COG2814	Major facilitator Superfamily
GSY53_RS17490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GSY53_RS17500	COG0756	dUTP diphosphatase activity
GSY53_RS17540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSY53_RS17555	COG3832	glyoxalase III activity
GSY53_RS17565	COG0697	spore germination
GSY53_RS17570	COG0531	amino acid
GSY53_RS17600	COG4195	phage-related replication protein
GSY53_RS17610	COG0346	lactoylglutathione lyase activity
GSY53_RS17615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GSY53_RS17620	COG1388	LysM domain
GSY53_RS17625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GSY53_RS17630	COG4224	UPF0291 protein
GSY53_RS17635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GSY53_RS17645	COG3763	UPF0154 protein
GSY53_RS17655	COG0785	Cytochrome C biogenesis protein
GSY53_RS17660	COG2201	protein-glutamate methylesterase activity
GSY53_RS17665	COG4846	Membrane protein involved in cytochrome C biogenesis
GSY53_RS17675	COG0071	Belongs to the small heat shock protein (HSP20) family
GSY53_RS17690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GSY53_RS17695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS17715	COG0824	Thioesterase
GSY53_RS17725	COG4841	protein insertion into membrane
GSY53_RS17730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GSY53_RS17735	COG1832	CoA-binding protein
GSY53_RS17740	COG0187	DNA topoisomerase II activity
GSY53_RS17745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GSY53_RS17755	COG1115	amino acid carrier protein
GSY53_RS17760	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GSY53_RS17770	COG5520	Belongs to the glycosyl hydrolase 30 family
GSY53_RS17775	COG3507	Belongs to the glycosyl hydrolase 43 family
GSY53_RS17780	COG2246	polysaccharide biosynthetic process
GSY53_RS17785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSY53_RS17790	COG0586	Pfam SNARE associated Golgi protein
GSY53_RS17795	COG2404	hydrolase activity, acting on ester bonds
GSY53_RS17800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GSY53_RS17805	COG1024	Enoyl-CoA hydratase
GSY53_RS17810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSY53_RS17815	COG0511	ligase activity, forming carbon-carbon bonds
GSY53_RS17820	COG0439	Biotin carboxylase
GSY53_RS17825	COG0318	PFAM AMP-dependent synthetase and ligase
GSY53_RS17830	COG1960	acyl-CoA dehydrogenase activity
GSY53_RS17845	COG1649	PFAM Uncharacterised BCR, COG1649
GSY53_RS17855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS17855	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GSY53_RS17860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS17865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS17870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS17875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSY53_RS17880	COG2027	D-alanyl-D-alanine carboxypeptidase
GSY53_RS17885	COG2017	converts alpha-aldose to the beta-anomer
GSY53_RS17890	COG0534	Mate efflux family protein
GSY53_RS17905	COG0582	viral genome integration into host DNA
GSY53_RS17910	COG0166	Belongs to the GPI family
GSY53_RS17915	COG0405	Gamma-glutamyltransferase
GSY53_RS17920	COG0583	DNA-binding transcription factor activity
GSY53_RS17925	COG0604	alcohol dehydrogenase
GSY53_RS17930	COG0493	'glutamate synthase
GSY53_RS17935	COG0067	glutamate synthase
GSY53_RS17935	COG0070	glutamate synthase
GSY53_RS17935	COG0069	glutamate synthase activity
GSY53_RS17940	COG0583	DNA-binding transcription factor activity
GSY53_RS17945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GSY53_RS17950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GSY53_RS17960	COG0300	oxidoreductase activity
GSY53_RS17965	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GSY53_RS17975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSY53_RS17980	COG2814	Major facilitator Superfamily
GSY53_RS17985	COG1070	Carbohydrate kinase
GSY53_RS17990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GSY53_RS17995	COG0243	molybdopterin cofactor binding
GSY53_RS18025	COG5278	phosphoserine phosphatase activity
GSY53_RS18025	COG0840	transmembrane signaling receptor activity
GSY53_RS18030	COG2368	4-hydroxyphenylacetate
GSY53_RS18035	COG4305	rare lipoprotein A
GSY53_RS18040	COG3619	membrane
GSY53_RS18045	COG3866	Pectate lyase
GSY53_RS18050	COG2135	peptidase activity
GSY53_RS18060	COG2140	Oxalate decarboxylase
GSY53_RS18075	COG0456	acetyltransferase
GSY53_RS18095	COG2720	vancomycin resistance protein
GSY53_RS18105	COG3655	Transcriptional regulator
GSY53_RS18110	COG3739	integral membrane protein
GSY53_RS18115	COG0583	DNA-binding transcription factor activity
GSY53_RS18120	COG0697	spore germination
GSY53_RS18130	COG0693	protein deglycase activity
GSY53_RS18135	COG2367	Beta-lactamase
GSY53_RS18160	COG3848	Pyruvate phosphate dikinase
GSY53_RS18160	COG0574	Belongs to the PEP-utilizing enzyme family
GSY53_RS18165	COG0726	polysaccharide deacetylase
GSY53_RS18170	COG2314	TM2 domain
GSY53_RS18175	COG1396	sequence-specific DNA binding
GSY53_RS18190	COG2135	peptidase activity
GSY53_RS18225	COG0457	Tetratricopeptide repeat
GSY53_RS18250	COG5290	Psort location Cytoplasmic, score
GSY53_RS18275	COG5444	nuclease activity
GSY53_RS18280	COG4282	regulation of fungal-type cell wall biogenesis
GSY53_RS18285	COG1231	oxidoreductase activity
GSY53_RS18290	COG5434	Belongs to the glycosyl hydrolase 28 family
GSY53_RS18295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSY53_RS18300	COG0662	Cupin 2, conserved barrel domain protein
GSY53_RS18300	COG2207	Transcriptional regulator
GSY53_RS18305	COG0456	acetyltransferase
GSY53_RS18310	COG1309	transcriptional regulator
GSY53_RS18315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSY53_RS18320	COG3708	Transcriptional regulator
GSY53_RS18325	COG2378	regulation of single-species biofilm formation
GSY53_RS18335	COG0640	Transcriptional regulator
GSY53_RS18340	COG0741	lytic transglycosylase activity
GSY53_RS18345	COG2322	membrane
GSY53_RS18360	COG1619	proteins homologs of microcin C7 resistance protein MccF
GSY53_RS18365	COG3239	Fatty acid desaturase
GSY53_RS18370	COG4585	Histidine kinase
GSY53_RS18375	COG2197	response regulator
GSY53_RS18380	COG1388	LysM domain
GSY53_RS18380	COG3584	3D domain protein
GSY53_RS18385	COG0514	ATP-dependent DNA helicase (RecQ)
GSY53_RS18395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GSY53_RS18400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GSY53_RS18415	COG0071	Belongs to the small heat shock protein (HSP20) family
GSY53_RS18440	COG1012	belongs to the aldehyde dehydrogenase family
GSY53_RS18445	COG1657	PFAM Prenyltransferase squalene oxidase
GSY53_RS18450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GSY53_RS18455	COG0733	neurotransmitter:sodium symporter activity
GSY53_RS18460	COG0385	Bile acid
GSY53_RS18465	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSY53_RS18470	COG0567	Dehydrogenase, E1 component
GSY53_RS18475	COG4548	von Willebrand factor, type A
GSY53_RS18480	COG0714	Associated with various cellular activities
GSY53_RS18485	COG2032	superoxide dismutase activity
GSY53_RS18490	COG1388	LysM domain
GSY53_RS18490	COG0791	NLP P60 protein
GSY53_RS18495	COG1819	glycosyl
GSY53_RS18500	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GSY53_RS18505	COG0534	Mate efflux family protein
GSY53_RS18510	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY53_RS18515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSY53_RS18520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSY53_RS18530	COG2962	Rard protein
GSY53_RS18545	COG2610	gluconate transmembrane transporter activity
GSY53_RS18550	COG1942	4-Oxalocrotonate Tautomerase
GSY53_RS18555	COG1733	regulation of RNA biosynthetic process
GSY53_RS18560	COG0778	Nitroreductase
GSY53_RS18565	COG0400	carboxylic ester hydrolase activity
GSY53_RS18570	COG0346	lactoylglutathione lyase activity
GSY53_RS18580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSY53_RS18585	COG0793	Belongs to the peptidase S41A family
GSY53_RS18585	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS18590	COG2226	methyltransferase
GSY53_RS18600	COG1876	peptidase activity
GSY53_RS18605	COG0813	purine-nucleoside phosphorylase activity
GSY53_RS18620	COG0671	phosphoesterase, PA-phosphatase related
GSY53_RS18640	COG4479	Belongs to the UPF0346 family
GSY53_RS18650	COG1509	lysine 2,3-aminomutase activity
GSY53_RS18655	COG0456	acetyltransferase
GSY53_RS18660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSY53_RS18665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GSY53_RS18670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GSY53_RS18675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GSY53_RS18690	COG0456	acetyltransferase
GSY53_RS18695	COG0463	Glycosyl transferase, family 2
GSY53_RS18710	COG4641	Protein conserved in bacteria
GSY53_RS18715	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GSY53_RS18720	COG1086	Polysaccharide biosynthesis protein
GSY53_RS18725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSY53_RS18730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSY53_RS18735	COG1846	Transcriptional regulator
GSY53_RS18740	COG0534	Mate efflux family protein
GSY53_RS18750	COG4698	Protein conserved in bacteria
GSY53_RS18755	COG2755	lipolytic protein G-D-S-L family
GSY53_RS18760	COG1999	signal sequence binding
GSY53_RS18770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GSY53_RS18775	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GSY53_RS18780	COG1272	protein, Hemolysin III
GSY53_RS18785	COG0204	Acyl-transferase
GSY53_RS18790	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GSY53_RS18795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GSY53_RS18800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GSY53_RS18810	COG2136	Putative SAM-dependent methyltransferase
GSY53_RS18810	COG2521	methyltransferase
GSY53_RS18820	COG0129	dihydroxy-acid dehydratase activity
GSY53_RS18825	COG1413	lyase activity
GSY53_RS18830	COG1418	mRNA catabolic process
GSY53_RS18835	COG0386	Belongs to the glutathione peroxidase family
GSY53_RS18840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GSY53_RS18845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GSY53_RS18855	COG1278	Cold shock
GSY53_RS18875	COG0328	RNA-DNA hybrid ribonuclease activity
GSY53_RS18880	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GSY53_RS18885	COG0328	RNA-DNA hybrid ribonuclease activity
GSY53_RS18895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSY53_RS18910	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GSY53_RS18920	COG1755	Isoprenylcysteine carboxyl methyltransferase
GSY53_RS18925	COG3424	synthase
GSY53_RS18930	COG2233	PERMEase
GSY53_RS18935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSY53_RS18940	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GSY53_RS18950	COG0800	Aldolase
GSY53_RS18955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSY53_RS18960	COG1609	Transcriptional regulator
GSY53_RS18965	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GSY53_RS18970	COG1028	Short-chain dehydrogenase reductase Sdr
GSY53_RS18975	COG1199	ATP-dependent helicase activity
GSY53_RS18990	COG0116	Belongs to the methyltransferase superfamily
GSY53_RS19005	COG4474	Belongs to the UPF0398 family
GSY53_RS19020	COG3359	exonuclease
GSY53_RS19025	COG1111	helicase
GSY53_RS19025	COG1205	dead DEAH box helicase
GSY53_RS19030	COG2190	(PTS) system
GSY53_RS19035	COG0071	Belongs to the small heat shock protein (HSP20) family
GSY53_RS19070	COG3331	DNA recombination
GSY53_RS19075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSY53_RS19075	COG4499	WXG100 protein secretion system (Wss), protein YukC
GSY53_RS19085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GSY53_RS19090	COG3935	DnaD domain protein
GSY53_RS19095	COG0017	Asparaginyl-tRNA synthetase
GSY53_RS19100	COG0436	Aminotransferase
GSY53_RS19105	COG5353	protein conserved in bacteria
GSY53_RS19115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GSY53_RS19115	COG1199	ATP-dependent helicase activity
GSY53_RS19120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GSY53_RS19125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GSY53_RS19130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GSY53_RS19135	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GSY53_RS19135	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GSY53_RS19140	COG0617	tRNA 3'-terminal CCA addition
GSY53_RS19145	COG0438	transferase activity, transferring glycosyl groups
GSY53_RS19150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSY53_RS19155	COG1803	Methylglyoxal synthase
GSY53_RS19160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GSY53_RS19165	COG1694	Mazg nucleotide pyrophosphohydrolase
GSY53_RS19170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSY53_RS19180	COG4347	Protein of unknown function (DUF1405)
GSY53_RS19185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GSY53_RS19185	COG2010	Cytochrome c
GSY53_RS19190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GSY53_RS19195	COG0723	plastoquinol--plastocyanin reductase activity
GSY53_RS19205	COG5582	Belongs to the UPF0302 family
GSY53_RS19210	COG0457	Tetratricopeptide repeat
GSY53_RS19215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GSY53_RS19220	COG0287	Prephenate dehydrogenase
GSY53_RS19225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSY53_RS19230	COG0159	tryptophan synthase activity
GSY53_RS19235	COG0133	tryptophan synthase activity
GSY53_RS19240	COG0135	phosphoribosylanthranilate isomerase activity
GSY53_RS19250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GSY53_RS19255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GSY53_RS19260	COG4401	Chorismate mutase type I
GSY53_RS19265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GSY53_RS19270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GSY53_RS19275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GSY53_RS19280	COG0105	UTP biosynthetic process
GSY53_RS19285	COG0142	geranyltranstransferase activity
GSY53_RS19290	COG2226	methyltransferase
GSY53_RS19295	COG0142	geranyltranstransferase activity
GSY53_RS19305	COG0302	gtp cyclohydrolase
GSY53_RS19310	COG0776	regulation of translation
GSY53_RS19315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GSY53_RS19330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GSY53_RS19335	COG1160	GTP binding
GSY53_RS19360	COG1304	FMN binding
GSY53_RS19365	COG0539	negative regulation of cytoplasmic translation
GSY53_RS19370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GSY53_RS19380	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GSY53_RS19385	COG2959	enzyme of heme biosynthesis
GSY53_RS19390	COG3773	Cell wall hydrolase
GSY53_RS19390	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS19395	COG2339	peptidase activity
GSY53_RS19400	COG0492	ferredoxin-NADP+ reductase activity
GSY53_RS19405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GSY53_RS19410	COG4862	establishment of competence for transformation
GSY53_RS19415	COG1408	metallophosphoesterase
GSY53_RS19425	COG1388	LysM domain
GSY53_RS19430	COG1266	CAAX protease self-immunity
GSY53_RS19435	COG0514	ATP-dependent DNA helicase (RecQ)
GSY53_RS19440	COG4955	Helix-turn-helix domain
GSY53_RS19445	COG1141	Ferredoxin
GSY53_RS19450	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GSY53_RS19455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GSY53_RS19460	COG0710	3-dehydroquinate dehydratase activity
GSY53_RS19470	COG1595	DNA-templated transcription, initiation
GSY53_RS19475	COG5002	protein histidine kinase activity
GSY53_RS19480	COG0745	RESPONSE REGULATOR receiver
GSY53_RS19485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GSY53_RS19490	COG1333	cytochrome c biogenesis protein
GSY53_RS19495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSY53_RS19500	COG1187	pseudouridine synthase activity
GSY53_RS19505	COG0700	Nucleoside recognition
GSY53_RS19510	COG2715	membrane protein required for spore maturation
GSY53_RS19515	COG1686	Belongs to the peptidase S11 family
GSY53_RS19525	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GSY53_RS19530	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GSY53_RS19535	COG1547	Domain of unknown function (DUF309)
GSY53_RS19540	COG0456	acetyltransferase
GSY53_RS19545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GSY53_RS19550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSY53_RS19550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSY53_RS19555	COG0307	riboflavin synthase, alpha
GSY53_RS19560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GSY53_RS19560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GSY53_RS19570	COG0681	Belongs to the peptidase S26 family
GSY53_RS19580	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GSY53_RS19600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GSY53_RS19605	COG4086	secreted protein
GSY53_RS19610	COG0019	diaminopimelate decarboxylase activity
GSY53_RS19615	COG0697	spore germination
GSY53_RS19630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSY53_RS19650	COG1191	sigma factor activity
GSY53_RS19655	COG2172	sigma factor antagonist activity
GSY53_RS19660	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY53_RS19665	COG1686	Belongs to the peptidase S11 family
GSY53_RS19670	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GSY53_RS19675	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GSY53_RS19680	COG4974	Belongs to the 'phage' integrase family
GSY53_RS19690	COG0735	belongs to the Fur family
GSY53_RS19695	COG1300	Membrane
GSY53_RS19705	COG0281	malic enzyme
GSY53_RS19710	COG1757	Na H antiporter
GSY53_RS19715	COG1027	Aspartate ammonia-lyase
GSY53_RS19720	COG0252	asparaginase activity
GSY53_RS19725	COG1396	sequence-specific DNA binding
GSY53_RS19730	COG1379	DNA repair
GSY53_RS19735	COG0494	nUDIX hydrolase
GSY53_RS19745	COG0667	Aldo Keto reductase
GSY53_RS19755	COG1073	alpha beta
GSY53_RS19765	COG4918	Iron-sulphur cluster biosynthesis
GSY53_RS19770	COG0456	acetyltransferase
GSY53_RS19770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GSY53_RS19775	COG2329	Antibiotic biosynthesis monooxygenase
GSY53_RS19780	COG0456	acetyltransferase
GSY53_RS19790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSY53_RS19800	COG2211	Major facilitator Superfamily
GSY53_RS19805	COG0346	lactoylglutathione lyase activity
GSY53_RS19810	COG1072	(Pantothenic acid kinase))
GSY53_RS19815	COG3048	D-serine ammonia-lyase activity
GSY53_RS19820	COG0300	oxidoreductase activity
GSY53_RS19825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSY53_RS19830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GSY53_RS19835	COG4187	Peptidase family M20/M25/M40
GSY53_RS19840	COG1902	pentaerythritol trinitrate reductase activity
GSY53_RS19845	COG0596	Alpha beta hydrolase
GSY53_RS19855	COG1234	tRNA 3'-trailer cleavage
GSY53_RS19860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GSY53_RS19865	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GSY53_RS19870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSY53_RS19880	COG0706	membrane insertase activity
GSY53_RS19885	COG3361	conserved protein (COG2071)
GSY53_RS19890	COG2195	Cleaves the N-terminal amino acid of tripeptides
GSY53_RS19895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GSY53_RS19900	COG0346	lactoylglutathione lyase activity
GSY53_RS19910	COG1376	ErfK ybiS ycfS ynhG family protein
GSY53_RS19915	COG4129	membrane
GSY53_RS19920	COG1126	abc transporter atp-binding protein
GSY53_RS19925	COG0765	amino acid transport
GSY53_RS19930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSY53_RS19940	COG1597	lipid kinase activity
GSY53_RS19945	COG2814	Major facilitator Superfamily
GSY53_RS19950	COG0789	Transcriptional regulator
GSY53_RS19950	COG4978	Transcriptional regulator
GSY53_RS19955	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSY53_RS19960	COG0022	dehydrogenase e1 component
GSY53_RS19965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GSY53_RS19970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSY53_RS19975	COG3426	butyrate kinase activity
GSY53_RS19980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GSY53_RS19985	COG0280	phosphate acetyltransferase
GSY53_RS19990	COG3829	transcription factor binding
GSY53_RS19990	COG3290	protein histidine kinase activity
GSY53_RS20000	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GSY53_RS20005	COG2079	MmgE PrpD family protein
GSY53_RS20010	COG0372	Belongs to the citrate synthase family
GSY53_RS20015	COG1960	acyl-CoA dehydrogenase activity
GSY53_RS20020	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSY53_RS20025	COG0183	Belongs to the thiolase family
GSY53_RS20030	COG0584	glycerophosphoryl diester phosphodiesterase
GSY53_RS20035	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS20050	COG1902	pentaerythritol trinitrate reductase activity
GSY53_RS20055	COG0745	RESPONSE REGULATOR receiver
GSY53_RS20060	COG0750	zinc metalloprotease
GSY53_RS20065	COG0497	DNA recombination
GSY53_RS20070	COG1438	arginine binding
GSY53_RS20075	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GSY53_RS20080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GSY53_RS20085	COG0142	geranyltranstransferase activity
GSY53_RS20090	COG1722	exodeoxyribonuclease VII activity
GSY53_RS20095	COG1570	exodeoxyribonuclease VII activity
GSY53_RS20100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GSY53_RS20105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSY53_RS20110	COG1302	Protein conserved in bacteria
GSY53_RS20115	COG0439	Biotin carboxylase
GSY53_RS20120	COG0511	ligase activity, forming carbon-carbon bonds
GSY53_RS20160	COG3854	ATPases associated with a variety of cellular activities
GSY53_RS20170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GSY53_RS20175	COG0006	proline dipeptidase activity
GSY53_RS20180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GSY53_RS20190	COG3872	metal-dependent enzyme
GSY53_RS20200	COG1752	Esterase of the alpha-beta hydrolase superfamily
GSY53_RS20205	COG1321	iron dependent repressor
GSY53_RS20210	COG0095	Lipoate-protein ligase
GSY53_RS20215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GSY53_RS20220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSY53_RS20225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSY53_RS20230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GSY53_RS20235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GSY53_RS20250	COG1396	sequence-specific DNA binding
GSY53_RS20260	COG0681	Belongs to the peptidase S26 family
GSY53_RS20285	COG4940	Competence protein ComGF
GSY53_RS20295	COG4970	Tfp pilus assembly protein FimT
GSY53_RS20300	COG4537	Required for transformation and DNA binding
GSY53_RS20305	COG1459	type II secretion system
GSY53_RS20310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GSY53_RS20320	COG0598	Magnesium transport protein CorA
GSY53_RS20325	COG1253	flavin adenine dinucleotide binding
GSY53_RS20330	COG1366	Belongs to the anti-sigma-factor antagonist family
GSY53_RS20340	COG1393	Belongs to the ArsC family
GSY53_RS20350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSY53_RS20360	COG0011	TIGRFAM Protein of
GSY53_RS20370	COG2866	Carboxypeptidase
GSY53_RS20375	COG1368	sulfuric ester hydrolase activity
GSY53_RS20380	COG1940	carbohydrate kinase activity
GSY53_RS20385	COG4483	Protein conserved in bacteria
GSY53_RS20390	COG0705	Rhomboid family
GSY53_RS20390	COG0457	Tetratricopeptide repeat
GSY53_RS20400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GSY53_RS20405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GSY53_RS20425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GSY53_RS20430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GSY53_RS20435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GSY53_RS20440	COG0581	inorganic phosphate transmembrane transporter activity
GSY53_RS20445	COG0573	inorganic phosphate transmembrane transporter activity
GSY53_RS20450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GSY53_RS20460	COG0477	Major facilitator Superfamily
GSY53_RS20465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GSY53_RS20470	COG2839	Protein conserved in bacteria
GSY53_RS20475	COG5521	maltodextrose utilization protein MalA
GSY53_RS20485	COG1388	LysM domain
GSY53_RS20490	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GSY53_RS20495	COG4709	membrane
GSY53_RS20500	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GSY53_RS20505	COG0735	belongs to the Fur family
GSY53_RS20510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSY53_RS20520	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GSY53_RS20525	COG0513	Belongs to the DEAD box helicase family
GSY53_RS20535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GSY53_RS20540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GSY53_RS20545	COG2384	SAM-dependent methyltransferase
GSY53_RS20550	COG2010	Cytochrome c
GSY53_RS20555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSY53_RS20560	COG0358	DNA primase activity
GSY53_RS20565	COG1671	Belongs to the UPF0178 family
GSY53_RS20570	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GSY53_RS20575	COG0517	IMP dehydrogenase activity
GSY53_RS20580	COG0751	glycine-tRNA ligase activity
GSY53_RS20585	COG0752	glycyl-tRNA synthetase alpha subunit
GSY53_RS20590	COG1381	Involved in DNA repair and RecF pathway recombination
GSY53_RS20600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GSY53_RS20605	COG0295	cytidine deaminase activity
GSY53_RS20610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GSY53_RS20615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GSY53_RS20620	COG1480	7TM receptor with intracellular HD hydrolase
GSY53_RS20625	COG1702	phosphate starvation-inducible protein PhoH
GSY53_RS20630	COG0561	phosphatase activity
GSY53_RS20645	COG4864	UPF0365 protein
GSY53_RS20650	COG1030	water channel activity
GSY53_RS20655	COG1610	YqeY-like protein
GSY53_RS20660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GSY53_RS20665	COG1283	sodium-dependent phosphate transmembrane transporter activity
GSY53_RS20670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSY53_RS20675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GSY53_RS20680	COG2264	protein methyltransferase activity
GSY53_RS20685	COG0484	heat shock protein binding
GSY53_RS20690	COG0443	Heat shock 70 kDa protein
GSY53_RS20695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GSY53_RS20700	COG1420	regulation of RNA biosynthetic process
GSY53_RS20705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GSY53_RS20710	COG0481	GTPase activity
GSY53_RS20720	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS20725	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GSY53_RS20730	COG0268	Binds directly to 16S ribosomal RNA
GSY53_RS20735	COG1466	dna polymerase III delta subunit
GSY53_RS20750	COG0658	competence protein
GSY53_RS20750	COG2333	competence protein COMEC
GSY53_RS20755	COG2131	deaminase
GSY53_RS20760	COG1596	polysaccharide export
GSY53_RS20760	COG1555	photosystem II stabilization
GSY53_RS20765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GSY53_RS20770	COG2226	methyltransferase
GSY53_RS20775	COG0799	negative regulation of ribosome biogenesis
GSY53_RS20780	COG1713	HD superfamily hydrolase involved in NAD metabolism
GSY53_RS20785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GSY53_RS20790	COG1534	Rna-binding protein
GSY53_RS20795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSY53_RS20800	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GSY53_RS20805	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GSY53_RS20815	COG2755	lipolytic protein G-D-S-L family
GSY53_RS20820	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS20820	COG5632	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS20825	COG0398	Pfam SNARE associated Golgi protein
GSY53_RS20830	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GSY53_RS20840	COG3209	COG3209 Rhs family protein
GSY53_RS20850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GSY53_RS20855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSY53_RS20860	COG0798	PFAM Bile acid sodium symporter
GSY53_RS20865	COG0346	lactoylglutathione lyase activity
GSY53_RS20870	COG0640	Transcriptional regulator
GSY53_RS20875	COG3403	YqcI/YcgG family
GSY53_RS20880	COG0457	Tetratricopeptide repeat
GSY53_RS20895	COG5444	nuclease activity
GSY53_RS20920	COG3409	Peptidoglycan-binding domain 1 protein
GSY53_RS20920	COG5632	N-Acetylmuramoyl-L-alanine amidase
GSY53_RS20925	COG4824	toxin secretion phage lysis holin
GSY53_RS20955	COG3778	Protein conserved in bacteria
GSY53_RS20960	COG3299	homolog of phage Mu protein gp47
GSY53_RS20965	COG3628	GPW Gp25 family protein
GSY53_RS20975	COG4193	domain, Protein
GSY53_RS20980	COG1652	LysM domain
GSY53_RS20985	COG3953	SLT domain
GSY53_RS20985	COG5280	Phage tail tape measure protein TP901
GSY53_RS21050	COG4653	Phage capsid family
GSY53_RS21055	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GSY53_RS21065	COG2369	cell adhesion
GSY53_RS21070	COG5518	Phage portal protein
GSY53_RS21075	COG1783	phage Terminase large subunit
GSY53_RS21080	COG5484	DNA packaging
GSY53_RS21090	COG3677	Transposase
GSY53_RS21105	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GSY53_RS21115	COG1484	DNA-dependent DNA replication
GSY53_RS21120	COG3935	DnaD domain protein
GSY53_RS21125	COG3723	Recombinational DNA repair protein, rece pathway
GSY53_RS21130	COG5377	YqaJ viral recombinase family
GSY53_RS21160	COG1476	TRANSCRIPTIONal
GSY53_RS21165	COG3620	sequence-specific DNA binding
GSY53_RS21175	COG0563	adenylate kinase activity
GSY53_RS21180	COG2856	Zn peptidase
GSY53_RS21185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GSY53_RS21190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSY53_RS21195	COG0798	PFAM Bile acid sodium symporter
GSY53_RS21200	COG0346	lactoylglutathione lyase activity
GSY53_RS21205	COG0640	Transcriptional regulator
GSY53_RS21210	COG3403	YqcI/YcgG family
GSY53_RS21215	COG0457	Tetratricopeptide repeat