locus-tag class description C3K59_RS00040 ENOG4108X3M OsmC Ohr family protein C3K59_RS00045 ENOG410814C multidrug resistance protein C3K59_RS00065 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C3K59_RS00070 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C3K59_RS00085 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C3K59_RS00090 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C3K59_RS00095 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C3K59_RS00100 ENOG4105U6W MutT NUDIX family protein C3K59_RS00105 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C3K59_RS00110 ENOG4106F1P AAA ATPase, central domain protein C3K59_RS00125 ENOG4107Y9E nuclease C3K59_RS00140 ENOG4106BHF C3K59_RS00170 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C3K59_RS00195 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C3K59_RS00225 ENOG4105E4C Lytic transglycosylase catalytic C3K59_RS00265 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C3K59_RS00280 ENOG41068G1 C3K59_RS00375 ENOG4106QVS C3K59_RS00400 ENOG4105K70 DNA-binding protein C3K59_RS00405 ENOG4105ZUG C3K59_RS00410 ENOG4105ZUG C3K59_RS00435 ENOG4108NE4 C3K59_RS00505 ENOG4107D0N C3K59_RS00620 ENOG4105GJD protein, conserved in bacteria C3K59_RS00650 ENOG4108J9Q DNA ligase C3K59_RS00655 ENOG4108RAV Conserved protein C3K59_RS00705 ENOG4106YR8 C3K59_RS00720 ENOG4106PTB DnaB-like helicase C terminal domain C3K59_RS00725 ENOG4106IVX C3K59_RS00735 ENOG4106J9J DNA polymerase C3K59_RS00770 ENOG4106210 phosphatase activity C3K59_RS00780 ENOG4105DVF Cytosine-specific methyltransferase C3K59_RS00880 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C3K59_RS00885 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C3K59_RS00910 ENOG4106ITI Glutaredoxin C3K59_RS00935 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C3K59_RS00965 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C3K59_RS01045 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) C3K59_RS01065 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C3K59_RS01070 ENOG4105CXI aluminum resistance protein C3K59_RS01075 ENOG4105KV4 Transcriptional regulator C3K59_RS01080 ENOG4105C5F glutamine synthetase C3K59_RS01085 ENOG41079P0 C3K59_RS01115 ENOG4106WTF Glycosyl transferase, family 2 C3K59_RS01120 ENOG4107RGC Glycosyl transferase, family 2 C3K59_RS01150 ENOG4107NTZ C3K59_RS01165 ENOG410907G C3K59_RS01185 ENOG4105DSG hydrolase family 43 C3K59_RS01190 ENOG4105E2R ROK family C3K59_RS01195 ENOG4105C93 Xylose Isomerase C3K59_RS01210 ENOG4107Y9E nuclease C3K59_RS01215 ENOG4105C54 Major Facilitator superfamily C3K59_RS01220 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C3K59_RS01230 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C3K59_RS01305 ENOG4108NHD germination protein C3K59_RS01320 ENOG4105FVX C3K59_RS01330 ENOG4105K7W phage-related replication protein C3K59_RS01345 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C3K59_RS01355 ENOG4108SVB resolvase C3K59_RS01360 ENOG4105VPS UPF0291 protein C3K59_RS01365 ENOG4105CV1 Transketolase (EC 2.2.1.1) C3K59_RS01385 ENOG4107QIV Cytochrome c biogenesis protein C3K59_RS01410 ENOG4107DZX Small, acid-soluble spore protein P C3K59_RS01420 ENOG4108I0Z Aconitate hydratase C3K59_RS01425 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C3K59_RS01440 ENOG41067CD Small, acid-soluble spore protein Tlp C3K59_RS01450 ENOG4105MI2 C3K59_RS01455 ENOG4105W8X HesB YadR YfhF-family protein C3K59_RS01460 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C3K59_RS01465 ENOG4105K4P CoA-binding domain protein C3K59_RS01470 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3K59_RS01490 ENOG4107QWR cellulase (EC 3.2.1.4) C3K59_RS01500 ENOG4108MYR Secreted protein C3K59_RS01505 ENOG4107SYN Glycosyl hydrolases family 43 C3K59_RS01515 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C3K59_RS01520 ENOG4107T5V SNARE associated Golgi C3K59_RS01530 ENOG4107QX3 carboxylase C3K59_RS01535 ENOG4105E39 Enoyl-CoA hydratase C3K59_RS01540 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C3K59_RS01545 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C3K59_RS01550 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C3K59_RS01555 ENOG4105CEY Amp-dependent synthetase and ligase C3K59_RS01560 ENOG4105C1G acyl-Coa dehydrogenase C3K59_RS01575 ENOG4105F32 YngK protein C3K59_RS01580 ENOG4106U2H Protein of unknown function (DUF1360) C3K59_RS01590 ENOG4105CEY Amp-dependent synthetase and ligase C3K59_RS01595 ENOG4105C0W non-ribosomal peptide synthetase C3K59_RS01605 ENOG4105C0W non-ribosomal peptide synthetase C3K59_RS01620 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family C3K59_RS01625 ENOG4108N2V aldose 1-epimerase C3K59_RS01630 ENOG4107QJQ Mate efflux family protein C3K59_RS01655 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C3K59_RS01665 ENOG4105CB2 alcohol dehydrogenase C3K59_RS01670 ENOG4105BZ8 glutamate synthase C3K59_RS01675 ENOG4105CBC glutamate synthase C3K59_RS01680 ENOG4105C5Q Transcriptional regulator C3K59_RS01685 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C3K59_RS01690 ENOG4105II7 pyrroline-5-carboxylate reductase C3K59_RS01710 ENOG4108UB7 C3K59_RS01720 ENOG4105IE8 Alpha-ketoglutarate permease C3K59_RS01725 ENOG4107U6E carbohydrate kinase FGGY C3K59_RS01730 ENOG4108M3J Dehydrogenase C3K59_RS01735 ENOG4108J2R molybdopterin oxidoreductase C3K59_RS01765 ENOG4105EC8 Methyl-accepting chemotaxis C3K59_RS01775 ENOG4108YQE rare lipoprotein a C3K59_RS01780 ENOG4105XPP Protein of unknown function (DUF1275) C3K59_RS01785 ENOG4108NR7 pectate lyase C3K59_RS01790 ENOG4108RAV Conserved protein C3K59_RS01800 ENOG4105F0F Oxalate decarboxylase C3K59_RS01840 ENOG4105VMP Transcriptional regulator C3K59_RS01845 ENOG4105NX3 Membrane C3K59_RS01865 ENOG4108V4B ThiJ pfpI C3K59_RS01870 ENOG4108J4B Beta-lactamase C3K59_RS01895 ENOG4107T94 Endo-14-beta-xylanase C3K59_RS01945 ENOG4108Z7R Chaperone CsaA C3K59_RS01950 ENOG4105FTV AraC Family Transcriptional Regulator C3K59_RS01955 ENOG4108HJF gCN5-related N-acetyltransferase C3K59_RS01965 ENOG4108W8B Beta-lactamase domain protein C3K59_RS01985 ENOG4105KTU Transcriptional regulator, arsr family C3K59_RS01995 ENOG4108SJC Membrane C3K59_RS02015 ENOG4105ECK Fatty Acid Desaturase C3K59_RS02020 ENOG4108ZGX Histidine kinase C3K59_RS02025 ENOG4108S01 response regulator C3K59_RS02030 ENOG41069ER domain protein C3K59_RS02035 ENOG4105C9U ATP-dependent DNA helicase RecQ C3K59_RS02045 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C3K59_RS02090 ENOG4105C26 Dehydrogenase C3K59_RS02100 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C3K59_RS02105 ENOG4105C8J )-transporter C3K59_RS02110 ENOG4105C09 Bile acid C3K59_RS02115 ENOG4105C7S Dehydrogenase C3K59_RS02125 ENOG4107T89 von Willebrand factor, type A C3K59_RS02130 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C3K59_RS02140 ENOG4105K4H Nlp p60 protein C3K59_RS02145 ENOG41087PP glycosyltransferase MGT family C3K59_RS02155 ENOG4107QMU Mate efflux family protein C3K59_RS02160 ENOG4106SCS STAS domain C3K59_RS02180 ENOG4105FR1 rard protein C3K59_RS02195 ENOG4105C6Z Gluconate C3K59_RS02200 ENOG41090U3 tautomerase C3K59_RS02215 ENOG4105FBA Phospholipase Carboxylesterase C3K59_RS02230 ENOG4105E1V na solute symporter C3K59_RS02250 ENOG4108VXD carboxy-peptidase C3K59_RS02255 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C3K59_RS02265 ENOG4106Z5R C3K59_RS02270 ENOG410841Q phosphoesterase PA-phosphatase related protein C3K59_RS02300 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C3K59_RS02305 ENOG4108TSC N-acetyltransferase C3K59_RS02310 ENOG4107S4Y M20 DapE family protein YgeY C3K59_RS02325 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3K59_RS02365 ENOG4107T32 3-phytase (EC 3.1.3.8) C3K59_RS02370 ENOG4105C5E polysaccharide biosynthesis protein C3K59_RS02375 ENOG4105E0X reductase C3K59_RS02380 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C3K59_RS02405 ENOG41090WU lipolytic protein G-D-S-L family C3K59_RS02410 ENOG4108KF3 Electron transport protein SCO1 SenC C3K59_RS02420 ENOG4105C7B Threonine dehydratase C3K59_RS02430 ENOG4108UT2 hemolysin iii C3K59_RS02440 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C3K59_RS02445 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C3K59_RS02460 ENOG4107YX5 Pfam:DUF548 C3K59_RS02465 ENOG4108Y6J UPF0403 protein C3K59_RS02470 ENOG4105C01 Dihydroxy-acid dehydratase C3K59_RS02485 ENOG4108V06 Glutathione peroxidase C3K59_RS02490 ENOG4105CVG Homoserine O-transsuccinylase C3K59_RS02535 ENOG41081VK Ribonuclease C3K59_RS02560 ENOG410890F Dynamin family C3K59_RS02575 ENOG41065KQ synthase C3K59_RS02585 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) C3K59_RS02590 ENOG4105CTD carboxy-peptidase C3K59_RS02595 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) C3K59_RS02600 ENOG4108UHU Aldolase C3K59_RS02605 ENOG4105D7K pfkb domain protein C3K59_RS02610 ENOG4108M60 Transcriptional regulator C3K59_RS02625 ENOG4105DVT helicase C3K59_RS02640 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C3K59_RS02655 ENOG4108UKS UPF0398 protein C3K59_RS02675 ENOG4108I5C dEAD DEAH box helicase C3K59_RS02725 ENOG4105BZ4 penicillin-binding protein C3K59_RS02735 ENOG4105CSM endonuclease III C3K59_RS02745 ENOG4105C5S asparaginyl-tRNA synthetase C3K59_RS02750 ENOG4105CHM Aminotransferase C3K59_RS02760 ENOG4105YAC C3K59_RS02765 ENOG4105DVT helicase C3K59_RS02770 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C3K59_RS02775 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C3K59_RS02780 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C3K59_RS02785 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C3K59_RS02795 ENOG4105CPK Glycosyl transferase (Group 1 C3K59_RS02800 ENOG4105FJR Lmbe family C3K59_RS02805 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C3K59_RS02810 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C3K59_RS02815 ENOG4108JYZ YitT family C3K59_RS02855 ENOG41068YB TPR repeat-containing protein C3K59_RS02860 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C3K59_RS02870 ENOG4105CIH Imidazole acetol-phosphate transaminase C3K59_RS02880 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C3K59_RS02885 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C3K59_RS02900 ENOG4105CRQ synthase (Component I) C3K59_RS02905 ENOG4105KHN chorismate mutase C3K59_RS02910 ENOG4105D49 3-dehydroquinate synthase C3K59_RS02915 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C3K59_RS02920 ENOG4105BZU Histidine kinase C3K59_RS02925 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C3K59_RS02930 ENOG4105EAH synthase C3K59_RS02935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C3K59_RS02940 ENOG4105XXQ heptaprenyl diphosphate synthase component I C3K59_RS02950 ENOG4105EUJ GTP cyclohydrolase i C3K59_RS02955 ENOG4105K70 DNA-binding protein C3K59_RS02960 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C3K59_RS02975 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C3K59_RS02980 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C3K59_RS02985 ENOG41065D1 C3K59_RS02990 ENOG4105S2F C3K59_RS03005 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) C3K59_RS03010 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C3K59_RS03015 ENOG4105CAT Cytidine monophosphate kinase C3K59_RS03045 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C3K59_RS03060 ENOG4107RGJ metallophosphoesterase C3K59_RS03075 ENOG4105I7S Abortive infection protein C3K59_RS03095 ENOG4108SAX Membrane C3K59_RS03100 ENOG4108JQ1 Dehydrogenase C3K59_RS03105 ENOG4105FF2 Type I DHQase C3K59_RS03120 ENOG4105BZU Histidine kinase C3K59_RS03125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K59_RS03130 ENOG4105CRE cytochrome C C3K59_RS03135 ENOG4107TWT Cytochrome c biogenesis protein C3K59_RS03145 ENOG4105FE9 pseudouridine synthase C3K59_RS03155 ENOG4108JIC nucleoside recognition domain protein C3K59_RS03160 ENOG4105DZ1 carboxypeptidase C3K59_RS03170 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C3K59_RS03190 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C3K59_RS03195 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C3K59_RS03200 ENOG4108R6K riboflavin synthase, subunit alpha C3K59_RS03205 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C3K59_RS03215 ENOG4105C3F Signal peptidase i C3K59_RS03225 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) C3K59_RS03260 ENOG4107ZE5 PPIases accelerate the folding of proteins C3K59_RS03265 ENOG4105PTM secreted protein C3K59_RS03270 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C3K59_RS03280 ENOG4105G6R Stage v sporulation protein ae C3K59_RS03290 ENOG4105CZ3 stage V sporulation protein ad C3K59_RS03295 ENOG41090VF Stage v sporulation protein ac C3K59_RS03310 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K59_RS03315 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C3K59_RS03320 ENOG41082AN stage II sporulation protein C3K59_RS03325 ENOG4105DZ1 carboxypeptidase C3K59_RS03330 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) C3K59_RS03335 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C3K59_RS03340 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C3K59_RS03350 ENOG4105I3K Ferric uptake regulator, Fur family C3K59_RS03355 ENOG4105MZ9 stage II sporulation protein m C3K59_RS03375 ENOG4108IJ0 Aspartate ammonia-lyase C3K59_RS03380 ENOG4105HDK L-asparaginase C3K59_RS03385 ENOG4108IMY Transcriptional regulator C3K59_RS03395 ENOG4108YZ4 nudix hydrolase C3K59_RS03405 ENOG4105CPC Aldo Keto reductase C3K59_RS03425 ENOG4106HZJ C3K59_RS03430 ENOG4105RHY Pfam:UPF0157 C3K59_RS03435 ENOG4105KAC Antibiotic biosynthesis monooxygenase C3K59_RS03440 ENOG4108XET gCN5-related N-acetyltransferase C3K59_RS03450 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C3K59_RS03460 ENOG4105E5W Transporter C3K59_RS03470 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase C3K59_RS03485 ENOG4108IXY short-chain dehydrogenase reductase C3K59_RS03490 ENOG41069FQ Metallo-beta-lactamase superfamily C3K59_RS03495 ENOG4105II7 pyrroline-5-carboxylate reductase C3K59_RS03505 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C3K59_RS03515 ENOG410861F 50S ribosomal protein L33 C3K59_RS03520 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C3K59_RS03525 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C3K59_RS03530 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C3K59_RS03535 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C3K59_RS03545 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) C3K59_RS03550 ENOG4108NA0 Uncharacterized conserved protein (COG2071) C3K59_RS03555 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C3K59_RS03565 ENOG4108ZVT methylmalonyl-coA epimerase C3K59_RS03575 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C3K59_RS03580 ENOG4108QEG Membrane C3K59_RS03585 ENOG4105CDA abc transporter atp-binding protein C3K59_RS03590 ENOG4105E5Q amino acid AbC transporter C3K59_RS03595 ENOG4108HW3 (ABC) transporter C3K59_RS03600 ENOG4108Y6J UPF0403 protein C3K59_RS03605 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C3K59_RS03625 ENOG4105CPP Dehydrogenase, E1 component C3K59_RS03640 ENOG4105CKM Branched-chain carboxylic acid kinase C3K59_RS03645 ENOG4107RDP Dehydrogenase C3K59_RS03655 ENOG4108JUB Transcriptional regulator C3K59_RS03660 ENOG4106CCJ Protein of unknown function (DUF2627) C3K59_RS03665 ENOG4105CR4 methylisocitrate lyase C3K59_RS03670 ENOG4105DXD 2-methylcitrate dehydratase C3K59_RS03680 ENOG4105C1G acyl-Coa dehydrogenase C3K59_RS03685 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3K59_RS03695 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3K59_RS03700 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C3K59_RS03715 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C3K59_RS03720 ENOG4107QQR Sporulation C3K59_RS03725 ENOG4105S1Z Stage IV sporulation protein B C3K59_RS03730 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C3K59_RS03735 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C3K59_RS03740 ENOG4105DX0 Hemolysin A C3K59_RS03750 ENOG4105CTB Polyprenyl synthetase C3K59_RS03755 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C3K59_RS03760 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C3K59_RS03765 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C3K59_RS03770 ENOG4105M7K Involved in the transcription termination process (By similarity) C3K59_RS03775 ENOG4108ZSR alkaline shock protein C3K59_RS03780 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C3K59_RS03800 ENOG410644B Stage III sporulation protein af C3K59_RS03810 ENOG4105KQ4 Stage iii sporulation protein ad C3K59_RS03815 ENOG4108CQH stage III sporulation protein AC C3K59_RS03820 ENOG4105KR5 Stage iii sporulation protein C3K59_RS03825 ENOG4105CD2 stage iii sporulation protein aa C3K59_RS03835 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C3K59_RS03840 ENOG4105DC7 peptidase M24 C3K59_RS03845 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C3K59_RS03855 ENOG4105CBJ Metal-dependent enzyme C3K59_RS03870 ENOG4105KST dependent repressor C3K59_RS03880 ENOG4105WZW rhodanese family C3K59_RS03885 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C3K59_RS03890 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C3K59_RS03895 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C3K59_RS03900 ENOG4105C0D helicase C3K59_RS03915 ENOG4108IMY Transcriptional regulator C3K59_RS03925 ENOG4105VFR signal peptidase C3K59_RS03980 ENOG41080XP Cbs domain C3K59_RS03990 ENOG4105C37 (CBS) domain C3K59_RS04015 ENOG4105C5X domain protein C3K59_RS04040 ENOG4105E0M Sulfatase C3K59_RS04055 ENOG4107ZXI Rhomboid family C3K59_RS04065 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C3K59_RS04090 ENOG41068DG YceG-like family C3K59_RS04095 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C3K59_RS04100 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C3K59_RS04105 ENOG4105E2Z phosphate ABC transporter (Permease C3K59_RS04110 ENOG4105C8U phosphate abc transporter C3K59_RS04115 ENOG4105CVA phosphate C3K59_RS04120 ENOG4107RF6 penicillin-binding protein C3K59_RS04130 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C3K59_RS04135 ENOG4105SXS Protein of unknown function (DUF456) C3K59_RS04150 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C3K59_RS04155 ENOG41063Y9 C3K59_RS04160 ENOG4108U5J '-nucleotidase C3K59_RS04165 ENOG4105N80 Ferric uptake regulator, Fur family C3K59_RS04170 ENOG4108JYZ YitT family C3K59_RS04175 ENOG41069ZM Protein of unknown function (DUF2624) C3K59_RS04180 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C3K59_RS04195 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C3K59_RS04200 ENOG4105EGD dinuclear metal center protein, YbgI family C3K59_RS04215 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K59_RS04220 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C3K59_RS04225 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 C3K59_RS04230 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C3K59_RS04240 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C3K59_RS04250 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) C3K59_RS04260 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C3K59_RS04265 ENOG4105KG3 cytidine deaminase C3K59_RS04270 ENOG4107YR5 Diacylglycerol kinase C3K59_RS04275 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C3K59_RS04280 ENOG4105CTJ Metal Dependent Phosphohydrolase C3K59_RS04285 ENOG4105C9A Phoh family C3K59_RS04295 ENOG41068P3 sporulation protein YqfC C3K59_RS04305 ENOG4105DI5 UPF0365 protein C3K59_RS04315 ENOG4105KTH gatB Yqey C3K59_RS04330 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C3K59_RS04335 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C3K59_RS04340 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C3K59_RS04350 ENOG4105CFG Acts as a chaperone (By similarity) C3K59_RS04355 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C3K59_RS04360 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C3K59_RS04365 ENOG4105CSA Coproporphyrinogen iii oxidase C3K59_RS04370 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C3K59_RS04380 ENOG4108ZRV stage ii sporulation protein p C3K59_RS04385 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) C3K59_RS04390 ENOG41082YS Binds directly to 16S ribosomal RNA C3K59_RS04415 ENOG4108UK2 deaminase C3K59_RS04420 ENOG4105KQC Competence protein C3K59_RS04430 ENOG4108D32 Methyltransferase C3K59_RS04440 ENOG4108WF2 Metal Dependent Phosphohydrolase C3K59_RS04445 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C3K59_RS04450 ENOG410812S Rna-binding protein C3K59_RS04455 ENOG4105E2X shikimate dehydrogenase C3K59_RS04460 ENOG4105CQW ribosome biogenesis GTPase YqeH C3K59_RS04465 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C3K59_RS04480 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C3K59_RS04485 ENOG41080BT SNARE associated Golgi C3K59_RS04500 ENOG4105WFK nuclease C3K59_RS04510 ENOG4107Y5K Resolvase C3K59_RS04520 ENOG4105D6J arsenicaL-resistance protein C3K59_RS04525 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase C3K59_RS04530 ENOG41085FC arsR family transcriptional regulator C3K59_RS04600 ENOG41064HX Suppressor of fused protein (SUFU) C3K59_RS04620 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C3K59_RS04655 ENOG410906S phage-like element pbsx protein xkdt C3K59_RS04660 ENOG41066EA baseplate J family protein C3K59_RS04665 ENOG4105MFU Protein of unknown function (DUF2634) C3K59_RS04675 ENOG4105X7F C3K59_RS04680 ENOG4108WZM domain protein C3K59_RS04685 ENOG4108FKH Transglycosylase SLT domain C3K59_RS04695 ENOG4105MTC XkdN-like protein C3K59_RS04705 ENOG4105FR7 XkdM protein, phage-like element PBSX C3K59_RS04710 ENOG4105PQS phage protein C3K59_RS04725 ENOG41060SN C3K59_RS04760 ENOG4106CGH Phage Mu protein F like protein C3K59_RS04765 ENOG4108MDF Phage Portal Protein C3K59_RS04770 ENOG4105IG6 Phage terminase, large subunit C3K59_RS04810 ENOG4105QBX endodeoxyribonuclease RusA C3K59_RS04830 ENOG4108PNI recT protein C3K59_RS04865 ENOG4106A7E Transcriptional regulator C3K59_RS04870 ENOG41067QW Transcriptional regulator C3K59_RS04880 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C3K59_RS04905 ENOG4105D3P Mannan endo-1,4-beta-mannosidase C3K59_RS04920 ENOG4105VFE sira family C3K59_RS04930 ENOG4105XTG Pfam:DUF156 C3K59_RS04935 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein C3K59_RS04945 ENOG41090E6 transcriptional regulator MERR family C3K59_RS04960 ENOG4105C37 (CBS) domain C3K59_RS04975 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family C3K59_RS04985 ENOG4105PGM cation diffusion facilitator family transporter C3K59_RS04990 ENOG41090U3 tautomerase C3K59_RS05020 ENOG4108ZRZ Transcriptional regulator (AsnC family) C3K59_RS05045 ENOG41064BW Protein of unknown function (DUF2568) C3K59_RS05060 ENOG41075D4 Aminoglycoside 6-adenylyltransferase C3K59_RS05075 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C3K59_RS05085 ENOG4107YCY Transcriptional regulator C3K59_RS05105 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C3K59_RS05110 ENOG4108HHA Transketolase C3K59_RS05125 ENOG4105UNS Pfam:DUF419 C3K59_RS05140 ENOG410904A RNA polymerase C3K59_RS05145 ENOG4105CPC Aldo Keto reductase C3K59_RS05155 ENOG4108KAM Transcriptional regulator C3K59_RS05165 ENOG41083Q9 chitosanase C3K59_RS05170 ENOG4105X5K response regulator receiver protein C3K59_RS05175 ENOG4108VQT Alpha beta hydrolase fold protein C3K59_RS05180 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein C3K59_RS05185 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein C3K59_RS05195 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase C3K59_RS05205 ENOG4105PGS Spore coat protein C3K59_RS05210 ENOG4105E2A Dehydrogenase C3K59_RS05225 ENOG4105VUF Transcriptional regulator C3K59_RS05235 ENOG4105DQ4 alcohol dehydrogenase C3K59_RS05240 ENOG4108Z0Z intracellular protease Pfpi family C3K59_RS05245 ENOG4108HKT sucrose-6-phosphate hydrolase C3K59_RS05250 ENOG4105F3R pts system mannose fructose sorbose family iid C3K59_RS05255 ENOG4105ETZ PTS System C3K59_RS05260 ENOG4108IQ3 PTS system C3K59_RS05265 ENOG4105YHU PTS system C3K59_RS05270 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C3K59_RS05280 ENOG4105C85 amino acid C3K59_RS05285 ENOG4105N14 lysine exporter protein LysE YggA C3K59_RS05290 ENOG4108NGU Transcriptional regulator C3K59_RS05300 ENOG4108P49 AntiSigma factor C3K59_RS05335 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C3K59_RS05340 ENOG4105C84 Histidine ammonia-lyase C3K59_RS05345 ENOG4105ZXK Dehydrogenase C3K59_RS05365 ENOG4105CJ1 ABC, transporter C3K59_RS05370 ENOG4108IAJ Nad-dependent epimerase dehydratase C3K59_RS05385 ENOG41082JN Transcriptional regulator C3K59_RS05405 ENOG4105TMB Formate nitrite transporter C3K59_RS05410 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) C3K59_RS05415 ENOG4108JB9 formate dehydrogenase C3K59_RS05430 ENOG4105C28 cystathionine C3K59_RS05445 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) C3K59_RS05460 ENOG4107XRG penicillin-binding protein C3K59_RS05465 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C3K59_RS05470 ENOG4105DBI uridine monophosphokinase C3K59_RS05475 ENOG4105CFP Peptidase U32 C3K59_RS05480 ENOG4105XYU peptidase (U32 family) C3K59_RS05490 ENOG4105HHA aminodeoxychorismate lyase C3K59_RS05495 ENOG4105VPH UPF0473 protein C3K59_RS05500 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C3K59_RS05505 ENOG4105VBH UPF0297 protein C3K59_RS05510 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C3K59_RS05515 ENOG4105C02 permease C3K59_RS05520 ENOG4105CDA abc transporter atp-binding protein C3K59_RS05525 ENOG4105CT1 (ABC) transporter C3K59_RS05530 ENOG4105EAD ABC transporter C3K59_RS05535 ENOG4105DRP amino acid AbC transporter C3K59_RS05545 ENOG41060CR C3K59_RS05565 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C3K59_RS05570 ENOG4105C3J Cysteine desulfurase C3K59_RS05580 ENOG4105D1H recombination factor protein RarA C3K59_RS05585 ENOG4105CUZ uba thif-type nad fad binding protein C3K59_RS05595 ENOG4105C9M aspartyl-trna synthetase C3K59_RS05600 ENOG4105CUT histidyl-tRNA synthetase C3K59_RS05610 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C3K59_RS05625 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C3K59_RS05630 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C3K59_RS05635 ENOG41067VP Protein of unknown function (DUF1049) C3K59_RS05640 ENOG4105NCW Trka-c domain protein C3K59_RS05645 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C3K59_RS05655 ENOG4105CKP Polysaccharide Biosynthesis Protein C3K59_RS05660 ENOG4108QG2 Membrane C3K59_RS05665 ENOG4105NAP C3K59_RS05670 ENOG4105VIE preprotein translocase, subunit YajC C3K59_RS05675 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C3K59_RS05680 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C3K59_RS05685 ENOG41061AI Protein of unknown function (DUF2905) C3K59_RS05690 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C3K59_RS05695 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C3K59_RS05705 ENOG4105IE8 Alpha-ketoglutarate permease C3K59_RS05710 ENOG4105CK5 oxidoreductase C3K59_RS05735 ENOG4105BZG amino acid carrier protein C3K59_RS05740 ENOG4105CDY transcriptional regulatory protein C3K59_RS05750 ENOG4106678 morphogenetic protein associated with SpoVID C3K59_RS05755 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C3K59_RS05760 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C3K59_RS05765 ENOG4108IYU L-aspartate oxidase C3K59_RS05780 ENOG4105CQC Prephenate dehydratase C3K59_RS05785 ENOG41090I5 UPF0735 ACT domain-containing protein C3K59_RS05790 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C3K59_RS05805 ENOG4105K46 50S ribosomal protein l27 C3K59_RS05815 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C3K59_RS05830 ENOG4107QMS site-determining protein C3K59_RS05835 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C3K59_RS05840 ENOG4105YHC Rod shape-determining protein MreD C3K59_RS05850 ENOG4105DFF Rod shape-determining protein mreb C3K59_RS05900 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C3K59_RS05935 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C3K59_RS05945 ENOG4108FKH Transglycosylase SLT domain C3K59_RS06110 ENOG4108IMY Transcriptional regulator C3K59_RS06120 ENOG4108C33 Resolvase C3K59_RS06125 ENOG4105W5Q DNA repair protein (RadC C3K59_RS06130 ENOG4108Z03 MAF-like protein C3K59_RS06145 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C3K59_RS06150 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C3K59_RS06160 ENOG4106AR7 Spore coat protein C3K59_RS06165 ENOG41068KH stage VI sporulation protein D C3K59_RS06170 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C3K59_RS06175 ENOG4105D52 delta-aminolevulinic acid dehydratase C3K59_RS06185 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C3K59_RS06195 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C3K59_RS06210 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C3K59_RS06215 ENOG4108IUQ atp-dependent protease C3K59_RS06220 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C3K59_RS06225 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C3K59_RS06235 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C3K59_RS06240 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C3K59_RS06245 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C3K59_RS06250 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C3K59_RS06255 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C3K59_RS06260 ENOG4108ZP8 Acetolactate synthase small subunit C3K59_RS06265 ENOG4105C7K acetolactate synthase C3K59_RS06275 ENOG4105I4A GCN5-related N-acetyltransferase C3K59_RS06280 ENOG4107KM7 Heat induced stress protein YflT C3K59_RS06290 ENOG4105M59 Phosphodiesterase, mj0936 family C3K59_RS06295 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C3K59_RS06300 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C3K59_RS06305 ENOG4108XJQ germination protein C3K59_RS06310 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C3K59_RS06315 ENOG41067TZ transcriptional regulator, MarR family C3K59_RS06320 ENOG4105PFC Transcriptional regulator C3K59_RS06330 ENOG4105E33 succinate dehydrogenase C3K59_RS06340 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C3K59_RS06350 ENOG4105CFH Aspartokinase C3K59_RS06355 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C3K59_RS06360 ENOG4105K63 Thioredoxin C3K59_RS06370 ENOG4105C10 Electron transfer flavoprotein C3K59_RS06375 ENOG4105BZJ Electron transfer flavoprotein C3K59_RS06380 ENOG41060WC Enoyl-CoA hydratase C3K59_RS06385 ENOG4107Z3H Transcriptional regulator, TetR family C3K59_RS06390 ENOG4105CEY Amp-dependent synthetase and ligase C3K59_RS06400 ENOG4105C98 muts2 protein C3K59_RS06405 ENOG4105DCG PHP domain protein C3K59_RS06420 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C3K59_RS06425 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C3K59_RS06430 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C3K59_RS06440 ENOG4108RWN rrna methyltransferase C3K59_RS06445 ENOG41067MF small acid-soluble spore protein C3K59_RS06455 ENOG4105CQB FAD linked oxidase domain protein C3K59_RS06460 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C3K59_RS06475 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C3K59_RS06480 ENOG4105DRS transport system, permease C3K59_RS06495 ENOG4108MDK Dehydrogenase C3K59_RS06505 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase C3K59_RS06510 ENOG4105EF1 ribulokinase C3K59_RS06520 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase C3K59_RS06525 ENOG4105CN9 Peptidase m42 family protein C3K59_RS06535 ENOG410696E Membrane C3K59_RS06540 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C3K59_RS06545 ENOG4105VJV 50s ribosomal protein L35 C3K59_RS06550 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C3K59_RS06560 ENOG41067MG lrgb family C3K59_RS06570 ENOG4105DY9 regulatoR C3K59_RS06575 ENOG4108HRK Histidine kinase C3K59_RS06585 ENOG4105C22 threonyL-tRNA synthetase C3K59_RS06590 ENOG4108TDW sporulation protein YtxC C3K59_RS06610 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C3K59_RS06615 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C3K59_RS06620 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C3K59_RS06625 ENOG4105KVH Transcriptional regulator C3K59_RS06630 ENOG4105F27 Major Facilitator C3K59_RS06635 ENOG4105CV8 reductase C3K59_RS06640 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C3K59_RS06650 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C3K59_RS06655 ENOG4105C2M dna polymerase I C3K59_RS06660 ENOG4105BZU Histidine kinase C3K59_RS06665 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3K59_RS06670 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C3K59_RS06675 ENOG4108HMX isocitrate dehydrogenase (NADP) C3K59_RS06680 ENOG4105BZN citrate synthase C3K59_RS06695 ENOG4105FS0 cytoplasmic membrane protein C3K59_RS06700 ENOG4105CA9 Pyruvate kinase C3K59_RS06705 ENOG4105CTQ phosphohexokinase C3K59_RS06715 ENOG4108IEY Carboxyl transferase domain C3K59_RS06720 ENOG4105C6K Malic enzyme C3K59_RS06725 ENOG4105C0B DNA polymerase III (alpha subunit) C3K59_RS06740 ENOG4106EVM C3K59_RS06745 ENOG4105SFS phosphoesterase RecJ domain protein C3K59_RS06760 ENOG410635A Membrane C3K59_RS06765 ENOG4105CH2 amidohydrolase C3K59_RS06785 ENOG4105DEN Luciferase family C3K59_RS06790 ENOG4105CDA abc transporter atp-binding protein C3K59_RS06815 ENOG4108XSB acetyltransferase, (GNAT) family C3K59_RS06820 ENOG4108KSA LysR family transcriptional regulator C3K59_RS06825 ENOG4105E8R UPF0173 metal-dependent hydrolase C3K59_RS06840 ENOG4105CH7 arginosuccinase C3K59_RS06845 ENOG4105CDH Citrulline--aspartate ligase C3K59_RS06850 ENOG4105EPU Molybdenum cofactor synthesis domain protein C3K59_RS06855 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C3K59_RS06870 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C3K59_RS06875 ENOG4105KBJ sporulation protein ytfj C3K59_RS06885 ENOG4105VK3 rdd domain containing protein C3K59_RS06890 ENOG4105D07 Signal peptide peptidase, SppA C3K59_RS06895 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C3K59_RS06900 ENOG4105EFZ amidohydrolase C3K59_RS06905 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C3K59_RS06940 ENOG4105U5Y Transcriptional regulator C3K59_RS06950 ENOG4105BZU Histidine kinase C3K59_RS06960 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C3K59_RS06965 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C3K59_RS06975 ENOG4105F1V Acetoin utilization protein C3K59_RS06980 ENOG4105W87 Cbs domain C3K59_RS06990 ENOG4105ER2 Ompa motb domain protein C3K59_RS06995 ENOG4107R0U MotA TolQ exbB proton channel C3K59_RS07000 ENOG4105ETE Transcriptional regulator (LacI family C3K59_RS07005 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C3K59_RS07025 ENOG4105DFU Cell wall formation (By similarity) C3K59_RS07035 ENOG4108VDD TRNA binding domain protein C3K59_RS07055 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ C3K59_RS07070 ENOG4105C6K Malic enzyme C3K59_RS07075 ENOG4105C8F Beta-lactamase domain protein C3K59_RS07080 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C3K59_RS07090 ENOG4108V15 phosphotransferase enzyme family C3K59_RS07095 ENOG4108IUM Glycogen debranching enzyme C3K59_RS07110 ENOG4107F58 2'-5' rna ligase C3K59_RS07115 ENOG4105C6T cysteine synthase C3K59_RS07140 ENOG4105YW5 deoR family transcriptional regulator C3K59_RS07155 ENOG4105CBX hi0933 family C3K59_RS07170 ENOG4105MU9 integral membrane protein C3K59_RS07195 ENOG41075H3 AraC family transcriptional regulator C3K59_RS07205 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C3K59_RS07215 ENOG4106A3M Cytochrome p-450 C3K59_RS07220 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C3K59_RS07230 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C3K59_RS07235 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3K59_RS07245 ENOG4105NTD Inherit from COG: Hydrolase C3K59_RS07275 ENOG41085GJ domain protein C3K59_RS07280 ENOG4105C8T Leucyl-tRNA synthetase C3K59_RS07290 ENOG4105BZU Histidine kinase C3K59_RS07295 ENOG410605W Major Facilitator C3K59_RS07300 ENOG4106UBQ C3K59_RS07310 ENOG4105C19 ABC transporter C3K59_RS07315 ENOG4105EWM Histidine kinase C3K59_RS07325 ENOG4107R34 abc transporter permease protein C3K59_RS07330 ENOG4105C19 ABC transporter C3K59_RS07345 ENOG4105DVE abc transporter atp-binding protein C3K59_RS07350 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C3K59_RS07365 ENOG4105N5T Radical SAM Protein C3K59_RS07380 ENOG4105E8V Alpha Beta Hydrolase Fold protein C3K59_RS07385 ENOG4108Z0R Transferase C3K59_RS07390 ENOG4105C85 amino acid C3K59_RS07395 ENOG4105CAQ asparagine synthetase C3K59_RS07400 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C3K59_RS07405 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase C3K59_RS07420 ENOG4105D2X ABC transporter substrate-binding protein C3K59_RS07430 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C3K59_RS07445 ENOG4108RMU ferritin dps family protein C3K59_RS07460 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) C3K59_RS07465 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C3K59_RS07470 ENOG4108V2W Carbonate dehydratase C3K59_RS07495 ENOG4105CC5 ABC transporter C3K59_RS07505 ENOG4105DIK (ABC) transporter C3K59_RS07510 ENOG4105DSE periplasmic solute binding protein C3K59_RS07515 ENOG4105DTQ mandelate racemase muconate lactonizing C3K59_RS07520 ENOG4105CEY Amp-dependent synthetase and ligase C3K59_RS07525 ENOG4108IPT Naphthoate synthase C3K59_RS07530 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C3K59_RS07535 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C3K59_RS07565 ENOG4107SBE Glycosyl transferase (Group 1 C3K59_RS07580 ENOG4107SBE Glycosyl transferase (Group 1 C3K59_RS07585 ENOG4108KS4 Spore coat protein C3K59_RS07600 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) C3K59_RS07610 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C3K59_RS07740 ENOG4105N67 Proton-coupled thiamine transporter YuaJ C3K59_RS07745 ENOG4105VRR gCN5-related N-acetyltransferase C3K59_RS07750 ENOG4105DZ6 Band 7 protein C3K59_RS07760 ENOG4106DF1 C3K59_RS07765 ENOG4108VNY MOSC domain protein C3K59_RS07770 ENOG4108JB8 alcohol dehydrogenase C3K59_RS07780 ENOG4105TRT Transcriptional regulator C3K59_RS07795 ENOG4105CZN Potassium uptake protein C3K59_RS07800 ENOG4107I77 yiaA/B two helix domain C3K59_RS07805 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C3K59_RS07825 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C3K59_RS07835 ENOG4105EE0 oxidoreductase C3K59_RS07840 ENOG4105DKG l-rhamnose isomerase C3K59_RS07845 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) C3K59_RS07850 ENOG4105DET Rhamnulokinase C3K59_RS07855 ENOG4105E98 transcriptional regulator DeoR family C3K59_RS07870 ENOG4105C8Q Methyl-accepting chemotaxis C3K59_RS07875 ENOG4105C8Q Methyl-accepting chemotaxis C3K59_RS07880 ENOG4105C8Q Methyl-accepting chemotaxis C3K59_RS07895 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C3K59_RS07910 ENOG4105C37 (CBS) domain C3K59_RS07925 ENOG4107PBV potassium channel C3K59_RS07930 ENOG4107PBV potassium channel C3K59_RS07945 ENOG4107QYV phosphohexose isomerase C3K59_RS07955 ENOG4107QW4 alcohol dehydrogenase C3K59_RS07960 ENOG4105WG9 Conserved Protein C3K59_RS07970 ENOG4105CHM Aminotransferase C3K59_RS07975 ENOG4108ZB6 transcriptional regulator AsnC family C3K59_RS07980 ENOG4108MUZ hydrolase C3K59_RS07990 ENOG4105C87 Aminotransferase class I and II C3K59_RS07995 ENOG4108HGU Histidine kinase C3K59_RS08000 ENOG4105Y38 Kinase-associated protein B C3K59_RS08020 ENOG4105BZ4 penicillin-binding protein C3K59_RS08025 ENOG4105KIR Thiol-disulfide oxidoreductase dcc C3K59_RS08040 ENOG4108MRH transcriptional regulatory protein C3K59_RS08045 ENOG4105DIH basic membrane C3K59_RS08050 ENOG4108JQ9 ABC transporter C3K59_RS08075 ENOG4105D65 subunit l C3K59_RS08080 ENOG4105HC0 Na H antiporter C3K59_RS08085 ENOG4108ZE9 Monovalent cation H antiporter subunit C C3K59_RS08090 ENOG4108JPZ Monovalent cation H antiporter subunit D C3K59_RS08095 ENOG4105SC1 monovalent cation H antiporter subunit E C3K59_RS08105 ENOG4105KJM monovalent cation h antiporter subunit g C3K59_RS08110 ENOG4105KA0 thioesterase Superfamily protein C3K59_RS08120 ENOG4105BZU Histidine kinase C3K59_RS08150 ENOG4105D58 Diguanylate phosphodiesterase C3K59_RS08155 ENOG4105DAP Nicotinate phosphoribosyltransferase C3K59_RS08180 ENOG4105C02 permease C3K59_RS08200 ENOG410904N short-chain dehydrogenase reductase C3K59_RS08235 ENOG4108K8K Transcriptional regulator C3K59_RS08240 ENOG4105DCF alanine dehydrogenase C3K59_RS08250 ENOG4105WQT MbtH domain protein C3K59_RS08255 ENOG4105CEY Amp-dependent synthetase and ligase C3K59_RS08260 ENOG4105WQI isochorismatase C3K59_RS08265 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C3K59_RS08270 ENOG4105E4F Isochorismate synthase C3K59_RS08275 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C3K59_RS08280 ENOG4105NIV Esterase C3K59_RS08300 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C3K59_RS08310 ENOG41069ER domain protein C3K59_RS08325 ENOG4105CEP NADH dehydrogenase C3K59_RS08330 ENOG4105CAY ferredoxin--nadp reductase C3K59_RS08350 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 C3K59_RS08355 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C3K59_RS08370 ENOG4105ZKE UPF0349 protein C3K59_RS08385 ENOG41083MR nifu domain-containing protein C3K59_RS08395 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C3K59_RS08400 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C3K59_RS08405 ENOG4105D6E homoserine dehydrogenase C3K59_RS08415 ENOG4108W5N phosphatidylglycerophosphatase a C3K59_RS08420 ENOG4105D4U had-superfamily hydrolase, subfamily iia C3K59_RS08430 ENOG4105MMD transcriptional regulator C3K59_RS08435 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) C3K59_RS08440 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C3K59_RS08445 ENOG4105FAA peptidase M23 C3K59_RS08450 ENOG4108YTE sporulation protein YunB C3K59_RS08455 ENOG4105KZD Domain of unknown function (DUF1805) C3K59_RS08460 ENOG4107R8B 5'-nucleotidase C3K59_RS08470 ENOG4105I3N Conserved Protein C3K59_RS08480 ENOG4105CD3 dihydroorotase C3K59_RS08485 ENOG4105G9B Transcriptional regulator C3K59_RS08500 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) C3K59_RS08505 ENOG4105VT2 5-hydroxyisourate hydrolase C3K59_RS08515 ENOG4107YV9 domain protein C3K59_RS08520 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C3K59_RS08535 ENOG4105XRQ Xanthine dehydrogenase accessory factor C3K59_RS08540 ENOG4105C5R Aminotransferase C3K59_RS08555 ENOG4108K8S endonuclease I C3K59_RS08560 ENOG4108IJ9 (ABC) transporter C3K59_RS08565 ENOG4105FDP GntR family transcriptional regulator C3K59_RS08570 ENOG4108KPW sugar kinase C3K59_RS08575 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C3K59_RS08580 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C3K59_RS08585 ENOG4105XN3 extracellular solute-binding protein family 1 C3K59_RS08590 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine C3K59_RS08595 ENOG4105PKS Excinuclease abc c subunit domain protein C3K59_RS08600 ENOG4107VFR oxidoreductase C3K59_RS08630 ENOG410780I phosphoprotein phosphatase activity C3K59_RS08635 ENOG4106BHF C3K59_RS08640 ENOG4106ANW SMI1_KNR4 C3K59_RS08645 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C3K59_RS08690 ENOG4108FKH Transglycosylase SLT domain C3K59_RS08785 ENOG4105CDU Replicative dna helicase C3K59_RS08810 ENOG4108ZUE Phage regulatory protein rha C3K59_RS08860 ENOG4105DIW FeS assembly protein SUFB C3K59_RS08865 ENOG4108UNV SUF system FeS assembly protein, NifU family C3K59_RS08870 ENOG4105C9B Cysteine desulfurase C3K59_RS08875 ENOG4105JRK feS assembly protein SufD C3K59_RS08880 ENOG4105C3K feS assembly ATPase SufC C3K59_RS08895 ENOG4105D01 (LipO)protein C3K59_RS08900 ENOG4108UMI ABC transporter, permease C3K59_RS08905 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C3K59_RS08930 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C3K59_RS08935 ENOG41080E8 Transcriptional regulator, Spx MgsR family C3K59_RS08940 ENOG4105C1G acyl-Coa dehydrogenase C3K59_RS08945 ENOG4105CHU acetyl-coa acetyltransferase C3K59_RS08980 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3K59_RS08985 ENOG4105MDS 4-oxalocrotonate tautomerase C3K59_RS08995 ENOG4105EGI Transcriptional regulator C3K59_RS09005 ENOG4105E0A ABC, transporter C3K59_RS09020 ENOG4105E1F short-chain dehydrogenase reductase C3K59_RS09025 ENOG4105HUF DNA protection during starvation protein C3K59_RS09030 ENOG4105C0H protease C3K59_RS09040 ENOG4105F3H Histidine kinase C3K59_RS09050 ENOG41067SE Tetr family transcriptional regulator C3K59_RS09055 ENOG4105C9Q fumarate hydratase class II C3K59_RS09080 ENOG4105WH1 Two component transcriptional regulator luxr family C3K59_RS09085 ENOG4105ENE Histidine kinase C3K59_RS09100 ENOG41087YS Phage shock protein A C3K59_RS09115 ENOG4108WBT adenosyltransferase C3K59_RS09120 ENOG4105E0A ABC, transporter C3K59_RS09125 ENOG4105EHG Permease protein C3K59_RS09130 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C3K59_RS09135 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C3K59_RS09140 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C3K59_RS09150 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3K59_RS09160 ENOG4106DF4 Sigma-70, region 4 C3K59_RS09170 ENOG4105F0F Oxalate decarboxylase C3K59_RS09180 ENOG4107RBB ABC transporter, permease C3K59_RS09185 ENOG4105C19 ABC transporter C3K59_RS09190 ENOG4108WMK Efflux transporter RND family MFP subunit C3K59_RS09195 ENOG4105E0A ABC, transporter C3K59_RS09200 ENOG4105EHG Permease protein C3K59_RS09205 ENOG4105DQ5 transport system permease protein C3K59_RS09215 ENOG4105D5Q Arginine ornithine antiporter C3K59_RS09225 ENOG4107K5X Membrane-bound metal-dependent hydrolase C3K59_RS09235 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C3K59_RS09240 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C3K59_RS09245 ENOG4105E0C molybdate abc transporter C3K59_RS09260 ENOG4105EEQ Na H antiporter C3K59_RS09265 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C3K59_RS09275 ENOG4105EEM helicase C3K59_RS09280 ENOG4105EN6 Membrane C3K59_RS09290 ENOG4107ZQN disulfide bond C3K59_RS09295 ENOG4105C59 p-type ATPase C3K59_RS09300 ENOG4105C59 p-type ATPase C3K59_RS09305 ENOG410681U heavy metal transport detoxification protein C3K59_RS09310 ENOG4105VPX protein, conserved in bacteria C3K59_RS09320 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C3K59_RS09325 ENOG4105ME7 Membrane C3K59_RS09330 ENOG4105RXJ C3K59_RS09335 ENOG4105KPY Small multidrug resistance protein C3K59_RS09340 ENOG4105KBX Transcriptional regulator, TetR family C3K59_RS09345 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C3K59_RS09355 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C3K59_RS09360 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C3K59_RS09370 ENOG4105XZU Preprotein translocase, subunit SecG C3K59_RS09395 ENOG4105KVH Transcriptional regulator C3K59_RS09400 ENOG4105C8Q Methyl-accepting chemotaxis C3K59_RS09405 ENOG4105R40 Glycine betaine carnitine choline C3K59_RS09410 ENOG4108HQR Glycine betaine C3K59_RS09415 ENOG4105E90 ABC transporter C3K59_RS09425 ENOG4107HG4 Transcriptional regulator C3K59_RS09430 ENOG4105R40 Glycine betaine carnitine choline C3K59_RS09435 ENOG4108HQR Glycine betaine C3K59_RS09440 ENOG4105E90 ABC transporter C3K59_RS09445 ENOG4108IJ8 ABC transporter C3K59_RS09450 ENOG4107HG4 Transcriptional regulator C3K59_RS09455 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C3K59_RS09460 ENOG4108QCI YvbH-like oligomerisation region C3K59_RS09470 ENOG4105T65 Membrane-associated protein C3K59_RS09475 ENOG4108W0I acetyltransferase C3K59_RS09490 ENOG4105FJR Lmbe family C3K59_RS09510 ENOG4108IAJ Nad-dependent epimerase dehydratase C3K59_RS09515 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C3K59_RS09520 ENOG4107QQG Dehydrogenase C3K59_RS09525 ENOG4105IIU Aminopeptidase C3K59_RS09530 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C3K59_RS09535 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C3K59_RS09540 ENOG4105CP7 Triose-phosphate isomerase C3K59_RS09545 ENOG4105BZA Phosphoglycerate kinase C3K59_RS09550 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C3K59_RS09565 ENOG4105CMD Transcriptional regulator, GntR family C3K59_RS09570 ENOG4105DEN Luciferase family C3K59_RS09575 ENOG4105GZI Transcriptional regulator C3K59_RS09580 ENOG4107RT3 EamA-like transporter family C3K59_RS09590 ENOG4105VRS hydrolase family 18 C3K59_RS09595 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C3K59_RS09600 ENOG4107QR9 Iron-sulfur cluster binding protein C3K59_RS09615 ENOG4105BZU Histidine kinase C3K59_RS09625 ENOG4108M15 ABC transporter C3K59_RS09630 ENOG4107R6F Alpha Beta Hydrolase Fold protein C3K59_RS09635 ENOG4108MJI response regulator C3K59_RS09650 ENOG4105EG2 ABC transporter, permease C3K59_RS09660 ENOG4107FKK extracellular solute-binding protein family 1 C3K59_RS09675 ENOG4105DAA L-lactate C3K59_RS09680 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K59_RS09690 ENOG4108ZPC Polysaccharide pyruvyl transferase C3K59_RS09695 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C3K59_RS09700 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family C3K59_RS09705 ENOG4105D3Q Sugar transferase C3K59_RS09715 ENOG4105K64 Glycosyl transferase, family 2 C3K59_RS09725 ENOG4107QRS glycosyltransferase group 2 family protein C3K59_RS09730 ENOG41068W6 Capsular polysaccharide biosynthesis protein C3K59_RS09735 ENOG4108KMV Glycosyl transferase (Group 1 C3K59_RS09740 ENOG4105K64 Glycosyl transferase, family 2 C3K59_RS09745 ENOG4108PQP glycosyl transferase group 1 C3K59_RS09755 ENOG4108QV3 biosynthesis protein C3K59_RS09760 ENOG4105HTX biosynthesis protein C3K59_RS09770 ENOG4105EBR Carboxylesterase C3K59_RS09780 ENOG4105PY6 Phenolic acid decarboxylase C3K59_RS09785 ENOG4105NI3 Protein of unknown function (DUF3237) C3K59_RS09795 ENOG4105FQP Beta-lactamase C3K59_RS09800 ENOG4105EDQ levansucrase EC 2.4.1.10 C3K59_RS09805 ENOG4108HKT sucrose-6-phosphate hydrolase C3K59_RS09810 ENOG4107QTZ amino acid C3K59_RS09835 ENOG4105DNP FAD linked oxidase domain protein C3K59_RS09840 ENOG4105IRW patatin-like phospholipase family protein C3K59_RS09850 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C3K59_RS09855 ENOG4107URF beta-phospho-glucomutase C3K59_RS09860 ENOG4105CG3 alpha amylase, catalytic region C3K59_RS09875 ENOG4105EG2 ABC transporter, permease C3K59_RS09880 ENOG4105D56 permease protein C3K59_RS09885 ENOG4107FKK extracellular solute-binding protein family 1 C3K59_RS09890 ENOG4108IUK alpha amylase, catalytic C3K59_RS09895 ENOG4105FKQ transcriptional regulator C3K59_RS09900 ENOG4108URH decarboxylase C3K59_RS09905 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain C3K59_RS09910 ENOG4105CHH sulfate transporter C3K59_RS09915 ENOG4108V2W Carbonate dehydratase C3K59_RS09920 ENOG4105C5I Dehydrogenase C3K59_RS09930 ENOG4105C19 ABC transporter C3K59_RS09935 ENOG4105EWM Histidine kinase C3K59_RS09945 ENOG4107A6P C3K59_RS09950 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C3K59_RS09955 ENOG4105KRI phosphocarrier protein (HPr C3K59_RS09960 ENOG4105CIE May be required for sporulation (By similarity) C3K59_RS09965 ENOG4105CHW UPF0052 protein C3K59_RS09970 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C3K59_RS09975 ENOG4108Z4K mutator MutT protein C3K59_RS09980 ENOG4105C3M thioredoxin reductase C3K59_RS09995 ENOG4105BZ1 (ABC) transporter C3K59_RS10005 ENOG4106FGC C3K59_RS10015 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C3K59_RS10020 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C3K59_RS10025 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C3K59_RS10030 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C3K59_RS10035 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C3K59_RS10045 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C3K59_RS10050 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C3K59_RS10060 ENOG4108E16 pectate lyase C3K59_RS10065 ENOG4108S4C acetyltransferase C3K59_RS10070 ENOG4107XGZ Hydrolase C3K59_RS10075 ENOG4105HKU nucleoside recognition domain-containing protein C3K59_RS10080 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C3K59_RS10085 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C3K59_RS10090 ENOG4105CE4 GlcNAc 6-P deacetylase C3K59_RS10095 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C3K59_RS10105 ENOG41088CQ domain protein C3K59_RS10110 ENOG41086DT Membrane protein of unknown function C3K59_RS10115 ENOG41067S9 phage shock protein C, PspC C3K59_RS10120 ENOG4108PY7 C3K59_RS10140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C3K59_RS10145 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C3K59_RS10160 ENOG4105MKU Transcriptional regulator C3K59_RS10180 ENOG4105CN1 protease C3K59_RS10185 ENOG4105CRP Part of the ABC transporter FtsEX involved in C3K59_RS10190 ENOG4105CAK Cell division ATP-binding protein ftsE C3K59_RS10215 ENOG4105MS2 ribosomal subunit Interface protein C3K59_RS10230 ENOG4105MQ3 flagellar protein FliS C3K59_RS10235 ENOG4107RT6 flagellar hook-associated C3K59_RS10240 ENOG41083S7 flagellar protein FlaG C3K59_RS10245 ENOG4105I03 Flagellin C3K59_RS10250 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C3K59_RS10255 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) C3K59_RS10260 ENOG4105MKD C3K59_RS10265 ENOG4105DTJ flagellar hook-associated protein C3K59_RS10270 ENOG4105E1Q flagellar hook-associated protein C3K59_RS10285 ENOG4105RU3 C3K59_RS10290 ENOG41081UC Inherit from COG: Competence protein C3K59_RS10310 ENOG4105WH1 Two component transcriptional regulator luxr family C3K59_RS10315 ENOG4105BZU Histidine kinase C3K59_RS10320 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C3K59_RS10325 ENOG4108KGH TRANSCRIPTIONal C3K59_RS10330 ENOG4105ESV Glycosyl transferase, family 4 C3K59_RS10335 ENOG4107EF8 Glycosyl transferase (Group 1 C3K59_RS10350 ENOG4105QZI O-Antigen Polymerase C3K59_RS10360 ENOG4107RA4 Glycosyl transferase (Group 1 C3K59_RS10365 ENOG4105PSV Polysaccharide Biosynthesis Protein C3K59_RS10370 ENOG4105D3Q Sugar transferase C3K59_RS10375 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C3K59_RS10395 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C3K59_RS10400 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C3K59_RS10405 ENOG4105EY8 ABC transporter C3K59_RS10415 ENOG4107SJB teichoic acid biosynthesis C3K59_RS10420 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) C3K59_RS10425 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase C3K59_RS10435 ENOG4107RZX Teichoic acid biosynthesis protein C3K59_RS10450 ENOG4105DG6 mannose-6-phosphate isomerase C3K59_RS10465 ENOG4108NHD germination protein C3K59_RS10470 ENOG4105C54 Major Facilitator superfamily C3K59_RS10475 ENOG4108KGH TRANSCRIPTIONal C3K59_RS10480 ENOG4105J7I hydrolase C3K59_RS10485 ENOG4105K4H Nlp p60 protein C3K59_RS10495 ENOG4105PNM synthesis protein C3K59_RS10505 ENOG4105N98 Capsule biosynthesis protein capB C3K59_RS10510 ENOG4105ETE Transcriptional regulator (LacI family C3K59_RS10515 ENOG4108RVA ribokinase C3K59_RS10520 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C3K59_RS10525 ENOG4105C2J ABC transporter C3K59_RS10530 ENOG4105CNN ABC, transporter C3K59_RS10535 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C3K59_RS10550 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C3K59_RS10555 ENOG4107FQX Alpha-acetolactate decarboxylase C3K59_RS10565 ENOG4107RSM transcriptional regulator C3K59_RS10580 ENOG4106UIA C3K59_RS10595 ENOG4107XC4 flavin reductase domain protein, FMN-binding C3K59_RS10605 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C3K59_RS10615 ENOG4105CAH Chromate C3K59_RS10620 ENOG4105FGV Chromate C3K59_RS10630 ENOG4108WS4 fmn reductase C3K59_RS10635 ENOG4107V2S Transcriptional regulator C3K59_RS10640 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) C3K59_RS10670 ENOG4108XI2 Domain of unknown function (DUF1963) C3K59_RS10675 ENOG4105C6Y Udp-glucose 6-dehydrogenase C3K59_RS10680 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C3K59_RS10685 ENOG4107YJ4 chain length determinant protein C3K59_RS10690 ENOG4105HTX biosynthesis protein C3K59_RS10700 ENOG4105KBK Zinc finger, swim domain protein C3K59_RS10705 ENOG4105C0D helicase C3K59_RS10710 ENOG410667J hydrolase C3K59_RS10715 ENOG4105E98 transcriptional regulator DeoR family C3K59_RS10720 ENOG4105Z8H single-stranded DNA-binding protein C3K59_RS10745 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C3K59_RS10750 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C3K59_RS10760 ENOG4105CGA flagellar basal-body rod protein FlgG C3K59_RS10770 ENOG4105DFF Rod shape-determining protein mreb C3K59_RS10775 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C3K59_RS10785 ENOG4107MII Sugar-specific transcriptional regulator TrmB C3K59_RS10790 ENOG4105CZM Major Facilitator C3K59_RS10795 ENOG4108M26 parallel beta-helix repeat protein C3K59_RS10805 ENOG41080V3 Major Facilitator superfamily C3K59_RS10810 ENOG4105D3W isochorismatase C3K59_RS10815 ENOG4107P26 C3K59_RS10820 ENOG4105BZU Histidine kinase C3K59_RS10830 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C3K59_RS10840 ENOG4105FRN stage II sporulation protein C3K59_RS10845 ENOG4107TCE N-acetyltransferase C3K59_RS10865 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C3K59_RS10870 ENOG4107TXC Transcriptional regulator C3K59_RS10875 ENOG4106BRK C3K59_RS10880 ENOG4108RYK Nad-dependent epimerase dehydratase C3K59_RS10885 ENOG4108Z40 Transcriptional regulator C3K59_RS10895 ENOG4105KI2 Urea amidohydrolase subunit beta C3K59_RS10900 ENOG4108YZ9 Urea amidohydrolase subunit gamma C3K59_RS10935 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C3K59_RS10945 ENOG4108TF4 von Willebrand factor, type A C3K59_RS10960 ENOG4105JFG SpoIID LytB domain protein C3K59_RS10965 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C3K59_RS10975 ENOG4106778 Protein of unknown function (DUF1146) C3K59_RS10985 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C3K59_RS10990 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C3K59_RS10995 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C3K59_RS11000 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C3K59_RS11020 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) C3K59_RS11030 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C3K59_RS11035 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C3K59_RS11040 ENOG4108UIC UPF0340 protein C3K59_RS11045 ENOG4108YZG isomerase C3K59_RS11050 ENOG4107WAU Protein tyrosine phosphatase C3K59_RS11055 ENOG410815N Probably functions as a manganese efflux pump (By similarity) C3K59_RS11060 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C3K59_RS11070 ENOG4108ZXQ stage ii sporulation protein r C3K59_RS11085 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C3K59_RS11090 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C3K59_RS11095 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C3K59_RS11105 ENOG4107TT2 Auxin Efflux Carrier C3K59_RS11110 ENOG4105C6K Malic enzyme C3K59_RS11115 ENOG4107104 thymidine kinase C3K59_RS11135 ENOG4105CBT Fructose-1,6-bisphosphatase C3K59_RS11140 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C3K59_RS11145 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway C3K59_RS11150 ENOG4105D2N Aldolase C3K59_RS11155 ENOG410812K response regulator receiver protein C3K59_RS11165 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C3K59_RS11175 ENOG4105C1G acyl-Coa dehydrogenase C3K59_RS11180 ENOG4105DF6 Fe-S oxidoreductase C3K59_RS11190 ENOG4105E5J UV damage endonuclease C3K59_RS11200 ENOG4105NAE bifunctional deaminase-reductase domain protein C3K59_RS11205 ENOG4105BZ1 (ABC) transporter C3K59_RS11225 ENOG4105R3A Nitrate reductase C3K59_RS11230 ENOG4108IUE nitrate reductase beta subunit C3K59_RS11250 ENOG4107V6Q Cyclic nucleotide-binding domain C3K59_RS11260 ENOG4105C75 arginyL-tRNA synthetase C3K59_RS11265 ENOG410684U Domain of unknown function (DUF1934) C3K59_RS11275 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E C3K59_RS11325 ENOG4107JM4 Tetratricopeptide repeat C3K59_RS11355 ENOG4108RDQ ABC transporter C3K59_RS11365 ENOG4105CYW agmatinase C3K59_RS11370 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C3K59_RS11375 ENOG4105BZ4 penicillin-binding protein C3K59_RS11380 ENOG4108XFG YwhD family C3K59_RS11385 ENOG4108Z4T Peptidase M50 C3K59_RS11390 ENOG41069HH 4-oxalocrotonate tautomerase C3K59_RS11395 ENOG41067TZ transcriptional regulator, MarR family C3K59_RS11400 ENOG4105C22 threonyL-tRNA synthetase C3K59_RS11405 ENOG4105C57 major facilitator superfamily C3K59_RS11410 ENOG41062ES Transcriptional regulator C3K59_RS11420 ENOG4105DCI Phosphohydrolase C3K59_RS11430 ENOG4108VCI transcription factor, rsfa family C3K59_RS11435 ENOG4108RNG Permease of the drug metabolite transporter C3K59_RS11440 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C3K59_RS11445 ENOG4105DUM transcriptional regulator, lysR family C3K59_RS11450 ENOG4108IJ2 phosphate acetyltransferase C3K59_RS11465 ENOG4105CHM Aminotransferase C3K59_RS11475 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase C3K59_RS11480 ENOG4105CHR reductase C3K59_RS11485 ENOG4106CHD Bacilysin biosynthesis protein bacB C3K59_RS11490 ENOG41061WN bacilysin biosynthesis protein C3K59_RS11495 ENOG4105FCW Major Facilitator superfamily C3K59_RS11510 ENOG4105C26 Dehydrogenase C3K59_RS11515 ENOG4105D82 Glutamate dehydrogenase C3K59_RS11525 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase C3K59_RS11530 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C3K59_RS11535 ENOG4105C1B dTDP-glucose 4-6-dehydratase C3K59_RS11540 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C3K59_RS11545 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG C3K59_RS11550 ENOG4107TY6 Acylneuraminate cytidylyltransferase C3K59_RS11560 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD C3K59_RS11565 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C3K59_RS11600 ENOG4105C26 Dehydrogenase C3K59_RS11605 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C3K59_RS11610 ENOG4108RJ9 Glycosyl transferase, family 2 C3K59_RS11615 ENOG4105DWF phosphomethylpyrimidine kinase C3K59_RS11630 ENOG4105C5Y PTS System C3K59_RS11635 ENOG4108QTI )-transporter C3K59_RS11650 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C3K59_RS11655 ENOG4105DEN Luciferase family C3K59_RS11660 ENOG4108DBC nitroreductase C3K59_RS11675 ENOG41060D1 Quinol oxidase C3K59_RS11685 ENOG4105BZ9 Cytochrome C oxidase, subunit I C3K59_RS11690 ENOG4105E2S oxidase) subunit II C3K59_RS11695 ENOG4107BMA Transglycosylase associated protein C3K59_RS11705 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C3K59_RS11710 ENOG4105WH5 Teichoic acid glycosylation protein C3K59_RS11740 ENOG4105DBE peroxidase C3K59_RS11745 ENOG410650H (LipO)protein C3K59_RS11750 ENOG4107SJW iron permease, FTR1 C3K59_RS11755 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C3K59_RS11765 ENOG4105CMU LysR family (Transcriptional regulator C3K59_RS11770 ENOG4105VAW lrga family C3K59_RS11775 ENOG41067MG lrgb family C3K59_RS11780 ENOG4105D8G Major Facilitator superfamily C3K59_RS11790 ENOG4105DR4 Methyltransferase C3K59_RS11805 ENOG4108YV3 Protein of unknown function (DUF2711) C3K59_RS11810 ENOG4105CK1 PTS System C3K59_RS11815 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin C3K59_RS11830 ENOG4105X1N Glycosyl transferase family 8 C3K59_RS11840 ENOG4105GVJ transcriptional regulator C3K59_RS11845 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C3K59_RS11850 ENOG4105IIU Aminopeptidase C3K59_RS11875 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C3K59_RS11890 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) C3K59_RS11895 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C3K59_RS11905 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C3K59_RS11910 ENOG4108VHC Short-chain dehydrogenase reductase Sdr C3K59_RS11915 ENOG4105CM2 brancheD-chain amino acid aminotransferase C3K59_RS11920 ENOG4105F8D glycoside hydrolase family 4 C3K59_RS11925 ENOG4105VCP PTS System C3K59_RS11930 ENOG4105CK1 PTS System C3K59_RS11935 ENOG4105VZJ PTS System C3K59_RS11940 ENOG4105EMD TRANSCRIPTIONal C3K59_RS11950 ENOG4108VX5 3-methyladenine DNA glycosylase C3K59_RS11955 ENOG4105CH6 catalase C3K59_RS11975 ENOG41069JR C3K59_RS11995 ENOG4105ETS cytosine purines uracil thiamine allantoin C3K59_RS12000 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C3K59_RS12005 ENOG4108JJ8 (ABC) transporter C3K59_RS12015 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C3K59_RS12020 ENOG4105C4M (Ubiquinol oxidase) subunit I C3K59_RS12025 ENOG4105D2K citrate carrier protein C3K59_RS12040 ENOG4107BJW polysaccharide deacetylase C3K59_RS12060 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C3K59_RS12070 ENOG4105CMR udp-glucose 4-epimerase C3K59_RS12080 ENOG4105BZU Histidine kinase C3K59_RS12085 ENOG4105WH1 Two component transcriptional regulator luxr family C3K59_RS12115 ENOG4105DTD Dehydrogenase C3K59_RS12120 ENOG4108IIH CoA-transferase subunit B C3K59_RS12125 ENOG4105D6N CoA-transferase, subunit a C3K59_RS12130 ENOG4105CY2 Citrate transporter C3K59_RS12135 ENOG4105DHI Methyltransferase C3K59_RS12155 ENOG4105CH6 catalase C3K59_RS12160 ENOG4105D4T Citrate transporter C3K59_RS12165 ENOG4108RZ2 Glycoside hydrolase family 16 C3K59_RS12170 ENOG4105CID antiterminator C3K59_RS12185 ENOG4105C1J atp-dependent rna helicase C3K59_RS12190 ENOG4107TDE lipolytic protein G-D-S-L family C3K59_RS12250 ENOG4105CNA YD repeat protein C3K59_RS12265 ENOG4105CS2 ec 3.2.1.21 C3K59_RS12270 ENOG4105C5Y PTS System C3K59_RS12320 ENOG4106Z5D Glycoside Hydrolase Family 43 C3K59_RS12335 ENOG4105C84 Histidine ammonia-lyase C3K59_RS12340 ENOG4105CGP Urocanate hydratase C3K59_RS12345 ENOG4105CI2 imidazolone-5-propionate hydrolase C3K59_RS12360 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C3K59_RS12365 ENOG4105D9N nucleoside C3K59_RS12375 ENOG4107RHR regulatoR C3K59_RS12380 ENOG4108TM9 integral membrane protein C3K59_RS12385 ENOG4105ENY Ethanolamine utilization protein eutH C3K59_RS12405 ENOG4108HW4 amino acid AbC transporter C3K59_RS12410 ENOG4105EAB amino acid AbC transporter C3K59_RS12425 ENOG4107QHE Choloylglycine hydrolase C3K59_RS12430 ENOG410667J hydrolase C3K59_RS12460 ENOG4108V5C ABC transporter C3K59_RS12490 ENOG4105D2N Aldolase C3K59_RS12495 ENOG4107TRN Xylose isomerase domain protein TIM barrel C3K59_RS12500 ENOG4105F0H myo-inositol catabolism protein C3K59_RS12505 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C3K59_RS12515 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C3K59_RS12520 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) C3K59_RS12525 ENOG4105D7K pfkb domain protein C3K59_RS12535 ENOG4105C26 Dehydrogenase C3K59_RS12545 ENOG4105CPC Aldo Keto reductase C3K59_RS12560 ENOG4107QNK )-transporter C3K59_RS12565 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C3K59_RS12575 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C3K59_RS12580 ENOG4105ST3 Transcriptional regulator C3K59_RS12585 ENOG4105C26 Dehydrogenase C3K59_RS12590 ENOG41085PJ rdd domain containing protein C3K59_RS12595 ENOG4108ITS PQQ enzyme repeat C3K59_RS12605 ENOG41085PJ rdd domain containing protein C3K59_RS12620 ENOG4105J7D transcriptional regulator C3K59_RS12625 ENOG4107JEE Short-chain dehydrogenase reductase Sdr C3K59_RS12630 ENOG41061AU MarR family Transcriptional regulator C3K59_RS12640 ENOG41067MG lrgb family C3K59_RS12655 ENOG4105G3Z GntR family transcriptional regulator C3K59_RS12660 ENOG4105CMG Carbohydrate kinase C3K59_RS12670 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C3K59_RS12675 ENOG4105D3R alkyl hydroperoxide reductase C3K59_RS12680 ENOG4108JU3 Alkyl hydroperoxide reductase C3K59_RS12695 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 C3K59_RS12710 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C3K59_RS12745 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) C3K59_RS12750 ENOG4105WQG acetyltransferase C3K59_RS12765 ENOG41066UZ arginase EC 3.5.3.1 C3K59_RS12770 ENOG4108IQI permease C3K59_RS12775 ENOG4105C8Y Acetylornithine aminotransferase C3K59_RS12800 ENOG41082BM Transcriptional regulator, arsr family C3K59_RS12805 ENOG4108JUB Transcriptional regulator C3K59_RS12820 ENOG4105C0H protease C3K59_RS12825 ENOG4105Q2H domain protein C3K59_RS12840 ENOG4105BZU Histidine kinase C3K59_RS12845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K59_RS12870 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C3K59_RS12875 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C3K59_RS12880 ENOG4105CDU Replicative dna helicase C3K59_RS12900 ENOG4105DJ2 Major Facilitator Superfamily C3K59_RS12905 ENOG4105EDW glycosyl transferase, family 39 C3K59_RS12910 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C3K59_RS12915 ENOG4105BZR domain protein C3K59_RS12920 ENOG4108XMW Membrane C3K59_RS12935 ENOG4105KVH Transcriptional regulator C3K59_RS12940 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase C3K59_RS12960 ENOG41090E6 transcriptional regulator MERR family C3K59_RS12970 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein C3K59_RS12975 ENOG4105DDN Pentapeptide repeat-containing protein C3K59_RS12980 ENOG4105D94 Major Facilitator Superfamily C3K59_RS12985 ENOG4107RSM transcriptional regulator C3K59_RS12990 ENOG41082BV acetyltransferase C3K59_RS12995 ENOG41081I9 integral membrane protein C3K59_RS13010 ENOG4108U05 Transcriptional regulator C3K59_RS13015 ENOG41082BV acetyltransferase C3K59_RS13025 ENOG4108U7W acetyltransferase C3K59_RS13030 ENOG4105UNS Pfam:DUF419 C3K59_RS13035 ENOG4105NAE bifunctional deaminase-reductase domain protein C3K59_RS13065 ENOG4108IPJ Membrane C3K59_RS13070 ENOG4105C7Z Conserved Protein C3K59_RS13075 ENOG4107FCW Abortive infection protein C3K59_RS13085 ENOG4108UW5 maltose o-acetyltransferase C3K59_RS13090 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C3K59_RS13100 ENOG4105CGK Exodeoxyribonuclease III C3K59_RS13105 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C3K59_RS13110 ENOG4108UUM single-stranded DNA-binding protein C3K59_RS13115 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C3K59_RS13120 ENOG4105C3G gtp-binding protein C3K59_RS13125 ENOG4108J2R molybdopterin oxidoreductase C3K59_RS13130 ENOG4105VDK protein, conserved in bacteria C3K59_RS13140 ENOG4108ZDA Sporulation protein YyaC C3K59_RS13145 ENOG4105FA0 parb-like partition protein C3K59_RS13150 ENOG4107QJE Chromosome Partitioning Protein C3K59_RS13165 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C3K59_RS13170 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C3K59_RS13175 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C3K59_RS13190 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C3K59_RS13200 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C3K59_RS13205 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C3K59_RS13210 ENOG410848D S4 domain protein YaaA C3K59_RS13225 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3K59_RS13230 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3K59_RS13265 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C3K59_RS13275 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) C3K59_RS13280 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) C3K59_RS13285 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C3K59_RS13295 ENOG4105ZMH deoxynucleoside kinase C3K59_RS13305 ENOG4105VRS hydrolase family 18 C3K59_RS13310 ENOG4105GTG Isochorismatase C3K59_RS13315 ENOG4108Z6B deaminase C3K59_RS13325 ENOG4105C6E dna polymerase iii C3K59_RS13330 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C3K59_RS13335 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C3K59_RS13345 ENOG41067KS pro-sigma K processing C3K59_RS13385 ENOG4105CDW Resistance protein C3K59_RS13390 ENOG4105CXN decarboxylase C3K59_RS13395 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C3K59_RS13400 ENOG4105X0R protein from nitrogen regulatory protein P-II C3K59_RS13405 ENOG4105XVJ Protein of unknown function (DUF327) C3K59_RS13410 ENOG4105FA2 dna polymerase iii C3K59_RS13415 ENOG4105MA4 psp1 domain protein C3K59_RS13420 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) C3K59_RS13425 ENOG41060K3 Methyltransferase C3K59_RS13430 ENOG4105VC4 domain protein C3K59_RS13435 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C3K59_RS13440 ENOG4105KRN Transcriptional regulator, abrb family C3K59_RS13445 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C3K59_RS13450 ENOG4105F8V Hydrolase, tatD family C3K59_RS13455 ENOG41069ER domain protein C3K59_RS13465 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C3K59_RS13470 ENOG4105XFA sporulation peptidase YabG C3K59_RS13475 ENOG4105W42 Veg protein C3K59_RS13480 ENOG4105XEW small acid-soluble spore protein C3K59_RS13485 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C3K59_RS13490 ENOG4105DFT pur operon repressor C3K59_RS13495 ENOG4105KME endoribonuclease L-psp C3K59_RS13500 ENOG4105K4W Could be involved in septation (By similarity) C3K59_RS13505 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C3K59_RS13510 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C3K59_RS13515 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C3K59_RS13520 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C3K59_RS13535 ENOG4108M14 stage v sporulation protein t C3K59_RS13550 ENOG41082I2 s4 domain protein C3K59_RS13555 ENOG4105VYY sporulation protein yabp C3K59_RS13570 ENOG41060GV RNA binding s1 domain protein C3K59_RS13600 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C3K59_RS13605 ENOG4108UGV hypoxanthine phosphoribosyltransferase C3K59_RS13610 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C3K59_RS13620 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C3K59_RS13625 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase C3K59_RS13630 ENOG4105C6T cysteine synthase C3K59_RS13635 ENOG4105CRQ synthase (Component I) C3K59_RS13640 ENOG4105DDQ anthranilate synthase C3K59_RS13645 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C3K59_RS13650 ENOG4105EEI dihydropteroate synthase C3K59_RS13655 ENOG4105KRF dihydroneopterin aldolase C3K59_RS13660 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C3K59_RS13670 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C3K59_RS13675 ENOG4105CRK lysyL-tRNA synthetase C3K59_RS13760 ENOG4108Z0C Uvrb UvrC protein C3K59_RS13765 ENOG41066A3 ATP guanido phosphotransferase C3K59_RS13775 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C3K59_RS13780 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) C3K59_RS13785 ENOG4105CTP PilT protein domain protein C3K59_RS13790 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C3K59_RS13795 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C3K59_RS13800 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C3K59_RS13805 ENOG4105D7W serine acetyltransferase C3K59_RS13810 ENOG4105C8N cysteinyl-tRNA synthetase C3K59_RS13815 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) C3K59_RS13820 ENOG4105C2N RNA methyltransferase TrmH family group 3 C3K59_RS13825 ENOG4105M0M Tetracycline resistance protein C3K59_RS13845 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C3K59_RS13860 ENOG4108VZM 50s ribosomal protein L10 C3K59_RS13870 ENOG4107Y49 methyltransferase C3K59_RS13875 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C3K59_RS13880 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C3K59_RS13885 ENOG4105XPM ribosomal protein C3K59_RS13890 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C3K59_RS13895 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C3K59_RS13900 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C3K59_RS13905 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C3K59_RS13915 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C3K59_RS13920 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C3K59_RS13925 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C3K59_RS13935 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C3K59_RS13950 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C3K59_RS13955 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C3K59_RS13965 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C3K59_RS13970 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C3K59_RS13980 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C3K59_RS13990 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C3K59_RS13995 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C3K59_RS14000 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C3K59_RS14005 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C3K59_RS14015 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C3K59_RS14020 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C3K59_RS14030 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C3K59_RS14045 ENOG41067V7 50S ribosomal protein L36 C3K59_RS14050 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C3K59_RS14055 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C3K59_RS14060 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C3K59_RS14065 ENOG4108ZT0 50S ribosomal protein l17 C3K59_RS14070 ENOG4108JJB ABC transporter C3K59_RS14075 ENOG4108JJB ABC transporter C3K59_RS14080 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C3K59_RS14085 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C3K59_RS14090 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C3K59_RS14095 ENOG4108UJD 30S ribosomal protein S9 C3K59_RS14100 ENOG4108I0C methyltransferase C3K59_RS14115 ENOG4105D1F ATP-binding protein C3K59_RS14130 ENOG4108NMV polysaccharide deacetylase C3K59_RS14165 ENOG410635T phage-like element pbsx protein C3K59_RS14180 ENOG41067QW Transcriptional regulator C3K59_RS14240 ENOG4105CDU Replicative dna helicase C3K59_RS14345 ENOG4105IG6 Phage terminase, large subunit C3K59_RS14350 ENOG4108MDF Phage Portal Protein C3K59_RS14355 ENOG4106CGH Phage Mu protein F like protein C3K59_RS14390 ENOG41060SN C3K59_RS14405 ENOG4105PQS phage protein C3K59_RS14410 ENOG4105FR7 XkdM protein, phage-like element PBSX C3K59_RS14415 ENOG4105MTC XkdN-like protein C3K59_RS14425 ENOG4108FKH Transglycosylase SLT domain C3K59_RS14430 ENOG4108WZM domain protein C3K59_RS14435 ENOG4105X7F C3K59_RS14445 ENOG4105MFU Protein of unknown function (DUF2634) C3K59_RS14450 ENOG41066EA baseplate J family protein C3K59_RS14455 ENOG410906S phage-like element pbsx protein xkdt C3K59_RS14465 ENOG41068G1 C3K59_RS14495 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C3K59_RS14500 ENOG4106ANW SMI1_KNR4 C3K59_RS14505 ENOG4106BHF C3K59_RS14525 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C3K59_RS14585 ENOG4105CHH sulfate transporter C3K59_RS14595 ENOG4108SA1 esterase C3K59_RS14615 ENOG410874W AraC family transcriptional regulator C3K59_RS14620 ENOG4105EHZ conserved protein UCP016719 C3K59_RS14625 ENOG4105D17 glycoside hydrolase, family 3 domain protein C3K59_RS14645 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C3K59_RS14685 ENOG4105EMN RNA polymerase sigma factor C3K59_RS14695 ENOG4105C8B TIGR00159 family C3K59_RS14700 ENOG4107U5W ybbr family C3K59_RS14705 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C3K59_RS14710 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C3K59_RS14720 ENOG4105D03 DNA-3-methyladenine glycosylase II C3K59_RS14730 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C3K59_RS14755 ENOG4105GPN Uncharacterized conserved protein (DUF2294) C3K59_RS14760 ENOG4105WAB arsR family transcriptional regulator C3K59_RS14780 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C3K59_RS14800 ENOG4105BZ1 (ABC) transporter C3K59_RS14805 ENOG4105BZ1 (ABC) transporter C3K59_RS14830 ENOG4105G0J serine threonine protein kinase C3K59_RS14840 ENOG4106K80 C3K59_RS14850 ENOG4106DDH Sporulation-specific SASP protein C3K59_RS14865 ENOG4107E6A Cytochrome p-450 C3K59_RS14875 ENOG4107QTZ amino acid C3K59_RS14885 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C3K59_RS14890 ENOG4105CXY transporter C3K59_RS14900 ENOG410645S MarR family Transcriptional regulator C3K59_RS14905 ENOG4105DCM major facilitator superfamily C3K59_RS14915 ENOG4106AXJ AraC family transcriptional regulator C3K59_RS14920 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C3K59_RS14925 ENOG4108TCS Glutamyl endopeptidase C3K59_RS14935 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C3K59_RS14940 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C3K59_RS14945 ENOG4107ZTW SNARE associated Golgi C3K59_RS14965 ENOG4105C72 UPF0176 protein C3K59_RS14975 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane C3K59_RS14980 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C3K59_RS14995 ENOG4105CM2 brancheD-chain amino acid aminotransferase C3K59_RS15000 ENOG4108IQI permease C3K59_RS15005 ENOG4108J5H Homocysteine s-methyltransferase C3K59_RS15020 ENOG4105CSV Glutaminase C3K59_RS15035 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase C3K59_RS15040 ENOG4105C26 Dehydrogenase C3K59_RS15045 ENOG4105DJB Major Facilitator Superfamily C3K59_RS15050 ENOG4105EQX glucarate dehydratase C3K59_RS15055 ENOG41073TP transcriptional regulator C3K59_RS15075 ENOG4106UX7 integral membrane protein C3K59_RS15115 ENOG4105MUA Resistance protein C3K59_RS15125 ENOG4105DGI Alkaline phosphatase C3K59_RS15130 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C3K59_RS15135 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C3K59_RS15140 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) C3K59_RS15145 ENOG4107EPV Aminotransferase class V C3K59_RS15150 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3K59_RS15155 ENOG4105J7D transcriptional regulator C3K59_RS15160 ENOG4107RB3 L-asparaginase C3K59_RS15165 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C3K59_RS15175 ENOG41060AI SEC-C motif C3K59_RS15185 ENOG4107Y7X LytTR C3K59_RS15190 ENOG4108IUW ABC transporter C3K59_RS15195 ENOG4108SDH ABC, transporter C3K59_RS15200 ENOG4107SET aldo keto reductase C3K59_RS15235 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C3K59_RS15245 ENOG4105DSE periplasmic solute binding protein C3K59_RS15250 ENOG4105DIK (ABC) transporter C3K59_RS15260 ENOG4105DEN Luciferase family C3K59_RS15265 ENOG4108N0M stress protein C3K59_RS15270 ENOG4106FN3 tellurium resistance protein C3K59_RS15275 ENOG4106FN3 tellurium resistance protein C3K59_RS15280 ENOG4107TS3 membrane protein, TerC C3K59_RS15285 ENOG4108TTB tellurium resistance protein C3K59_RS15295 ENOG41079KZ Major Facilitator Superfamily C3K59_RS15305 ENOG4108A65 Transcriptional regulator C3K59_RS15310 ENOG4108IJ7 Glycine betaine C3K59_RS15315 ENOG4107SQ8 Glycine betaine C3K59_RS15345 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C3K59_RS15380 ENOG4105EIG urea carboxylase-associated protein 1 C3K59_RS15385 ENOG4107RA1 nh(3)-dependent nad( ) synthetase C3K59_RS15390 ENOG4105I1F Resistance protein C3K59_RS15395 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C3K59_RS15400 ENOG41089UC methyltransferase, type 11 C3K59_RS15405 ENOG4105C5Q Transcriptional regulator C3K59_RS15410 ENOG4105I82 acetyl xylan esterase C3K59_RS15415 ENOG410756H nucleotidyltransferase C3K59_RS15425 ENOG4105C26 Dehydrogenase C3K59_RS15430 ENOG4105CK7 Sodium proline symporter C3K59_RS15435 ENOG4107YHD transcriptional regulator C3K59_RS15445 ENOG4108PJD permease C3K59_RS15450 ENOG4105U6C Alpha beta hydrolase fold protein C3K59_RS15460 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C3K59_RS15465 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C3K59_RS15470 ENOG4108IFG nitrite reductase, (NAD(P)H) C3K59_RS15495 ENOG4105S7A ErfK ybiS ycfS ynhG family protein C3K59_RS15510 ENOG4105E5Q amino acid AbC transporter C3K59_RS15515 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein C3K59_RS15535 ENOG4105CS2 ec 3.2.1.21 C3K59_RS15550 ENOG4105C8Q Methyl-accepting chemotaxis C3K59_RS15555 ENOG41080HJ 6-phospho 3-hexuloisomerase C3K59_RS15560 ENOG4108VA3 3-hexulose-6-phosphate synthase C3K59_RS15565 ENOG4105KVH Transcriptional regulator C3K59_RS15570 ENOG4105CEY Amp-dependent synthetase and ligase C3K59_RS15600 ENOG4105SX7 Transporter C3K59_RS15610 ENOG4105W8Z 4'-phosphopantetheinyl transferase C3K59_RS15620 ENOG4105CDA abc transporter atp-binding protein C3K59_RS15625 ENOG4105DRP amino acid AbC transporter C3K59_RS15635 ENOG4106P55 Transcriptional regulator C3K59_RS15640 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C3K59_RS15645 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C3K59_RS15650 ENOG41069ZX C3K59_RS15655 ENOG41069ZX C3K59_RS15665 ENOG4105DUX Transporter C3K59_RS15680 ENOG4105E1K spore germination protein C3K59_RS15700 ENOG4107WD8 ABC transporter, permease C3K59_RS15705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K59_RS15710 ENOG4105BZU Histidine kinase C3K59_RS15735 ENOG4105CFH Aspartokinase C3K59_RS15740 ENOG4105DHS permease protein C3K59_RS15745 ENOG4105CM4 permease protein C3K59_RS15750 ENOG4108IPW abc transporter atp-binding protein C3K59_RS15765 ENOG4105R8C Transcriptional regulator C3K59_RS15770 ENOG4108DBC nitroreductase C3K59_RS15775 ENOG41067V3 Antibiotic biosynthesis monooxygenase C3K59_RS15780 ENOG4105YVS arsR family transcriptional regulator C3K59_RS15790 ENOG4108JPW Aminotransferase C3K59_RS15795 ENOG4105C26 Dehydrogenase C3K59_RS15805 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C3K59_RS15810 ENOG4105KTB nuclear export factor GLE1 C3K59_RS15815 ENOG4108T5E Copper resistance protein C3K59_RS15820 ENOG4108ZYE Transcriptional regulator C3K59_RS15845 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C3K59_RS15850 ENOG4108ZX0 Signal peptidase I C3K59_RS15875 ENOG4105E7W lamb ycsf family protein C3K59_RS15880 ENOG4105C5A transporter C3K59_RS15885 ENOG4105CFM UPF0317 protein C3K59_RS15890 ENOG4105P4J Allophanate hydrolase, subunit 1 C3K59_RS15905 ENOG4105XJB lipolytic protein G-D-S-L family C3K59_RS15915 ENOG41061CK Antibiotic biosynthesis monooxygenase C3K59_RS15920 ENOG4107RVG penicillin-binding protein C3K59_RS15925 ENOG4107QM2 Aldo Keto reductase C3K59_RS15930 ENOG4105ETD TRANSCRIPTIONal C3K59_RS15940 ENOG4105HMZ Methyltransferase C3K59_RS15945 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3K59_RS15960 ENOG410606W general stress protein C3K59_RS15970 ENOG4105VCH membrane C3K59_RS15980 ENOG4105C9U ATP-dependent DNA helicase RecQ C3K59_RS16000 ENOG4107R8N Glycosyl transferase, family 2 C3K59_RS16010 ENOG4105C0X amino acid C3K59_RS16035 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C3K59_RS16045 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) C3K59_RS16050 ENOG4105EU9 C3K59_RS16055 ENOG4105QVS general stress protein C3K59_RS16060 ENOG41082W1 Cupin 2, conserved barrel domain protein C3K59_RS16075 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C3K59_RS16080 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C3K59_RS16085 ENOG4108MRH transcriptional regulatory protein C3K59_RS16090 ENOG4107QJT sodium dicarboxylate symporter C3K59_RS16095 ENOG4106F5Q Membrane C3K59_RS16100 ENOG4105CJ1 ABC, transporter C3K59_RS16115 ENOG4105FDT acyl-CoA dehydrogenase C3K59_RS16135 ENOG4105SZ6 Thioredoxin C3K59_RS16140 ENOG4105CPF Cell wall formation (By similarity) C3K59_RS16145 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C3K59_RS16150 ENOG4105C1J atp-dependent rna helicase C3K59_RS16155 ENOG410905X membrane-flanked domain protein C3K59_RS16160 ENOG4105CKV Membrane C3K59_RS16170 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C3K59_RS16175 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C3K59_RS16180 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C3K59_RS16190 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C3K59_RS16195 ENOG4107MMM Anti-sigma-factor antagonist C3K59_RS16200 ENOG4105FUA antagonist C3K59_RS16205 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C3K59_RS16210 ENOG4107SGM protein serine threonine phosphatase C3K59_RS16215 ENOG4105WN5 stage II sporulation protein C3K59_RS16220 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C3K59_RS16230 ENOG41064BQ Phosphatase C3K59_RS16295 ENOG4105VZ8 Transcriptional regulator C3K59_RS16320 ENOG4108V4B ThiJ pfpI C3K59_RS16325 ENOG4105VEQ Cold shock protein C3K59_RS16330 ENOG4108VJ1 Transcriptional regulator (CarD family C3K59_RS16340 ENOG4108MCI Transcriptional regulator, ARAC family C3K59_RS16345 ENOG4108UZ3 Transporter C3K59_RS16350 ENOG41086D8 Transcriptional regulator C3K59_RS16355 ENOG4107U9B transcriptional regulator C3K59_RS16360 ENOG4105DXI Major Facilitator superfamily C3K59_RS16370 ENOG4105CZ9 Domain of unknown function (DU1801) C3K59_RS16375 ENOG4105GIG C3K59_RS16385 ENOG4105KRI phosphocarrier protein (HPr C3K59_RS16390 ENOG4105ST3 Transcriptional regulator C3K59_RS16400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3K59_RS16405 ENOG4108ZMQ domain protein C3K59_RS16410 ENOG4105MJ9 esterase C3K59_RS16415 ENOG4107Z6X Transcriptional regulator C3K59_RS16425 ENOG4105EQ0 Major Facilitator superfamily C3K59_RS16430 ENOG4108JGH Tetr family transcriptional regulator C3K59_RS16440 ENOG41082YX Transcriptional regulator, arsr family C3K59_RS16445 ENOG4107R5R arsenical pump membrane protein C3K59_RS16455 ENOG4105Z7P Acetyltransferase (GNAT) family C3K59_RS16460 ENOG4107Y9U Membrane C3K59_RS16470 ENOG4108SQ9 flavin reductase domain protein, FMN-binding C3K59_RS16475 ENOG4108ZHR arsR family transcriptional regulator C3K59_RS16480 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C3K59_RS16500 ENOG4108VB1 regulatoR C3K59_RS16505 ENOG4105EYF MMPL domain protein C3K59_RS16510 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C3K59_RS16515 ENOG4108UQV Membrane C3K59_RS16520 ENOG4108Z5V transcriptional regulator, merr family C3K59_RS16525 ENOG41076HS cation diffusion facilitator family transporter C3K59_RS16530 ENOG4108TVJ Nitroreductase C3K59_RS16535 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C3K59_RS16540 ENOG4108VGI doxx family C3K59_RS16545 ENOG4105XXY Thioredoxin C3K59_RS16565 ENOG410900G Protein of unknown function (DUF421) C3K59_RS16570 ENOG4108QY0 Membrane C3K59_RS16590 ENOG4105PF9 Transcriptional regulator C3K59_RS16610 ENOG4105C85 amino acid C3K59_RS16620 ENOG41062A4 Transcriptional regulator C3K59_RS16625 ENOG4105EYF MMPL domain protein C3K59_RS16630 ENOG4108TVJ Nitroreductase C3K59_RS16635 ENOG4105FS7 Transcriptional regulator C3K59_RS16640 ENOG4105C2C drug resistance transporter, Bcr CflA C3K59_RS16650 ENOG4105DRR Transcriptional regulator, GntR family C3K59_RS16670 ENOG4105G6Z alkaline phosphatase C3K59_RS16675 ENOG4108ZMX Domain of unknown function (DU1801) C3K59_RS16685 ENOG4108YM7 Gcn5-related n-acetyltransferase C3K59_RS16690 ENOG4107TVP HD domain protein C3K59_RS16695 ENOG41090UD (LipO)protein C3K59_RS16700 ENOG4105F27 Major Facilitator C3K59_RS16705 ENOG4105VZJ PTS System C3K59_RS16710 ENOG4105VCP PTS System C3K59_RS16715 ENOG4105CK1 PTS System C3K59_RS16720 ENOG4105CS2 ec 3.2.1.21 C3K59_RS16725 ENOG4108TZY GntR Family Transcriptional Regulator C3K59_RS16730 ENOG4105EVU fructokinase C3K59_RS16735 ENOG4105DG6 mannose-6-phosphate isomerase C3K59_RS16740 ENOG4105D3P Mannan endo-1,4-beta-mannosidase C3K59_RS16785 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C3K59_RS16790 ENOG4105K8N protein family UPF0079, ATPase C3K59_RS16795 ENOG41072GX Peptidase M22 Glycoprotease C3K59_RS16800 ENOG410801F ribosomal-protein-alanine acetyltransferase C3K59_RS16805 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C3K59_RS16810 ENOG4105C5H ABC transporter C3K59_RS16815 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C3K59_RS16820 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C3K59_RS16825 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C3K59_RS16830 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C3K59_RS16840 ENOG4108TYN CAAX amino terminal protease family protein C3K59_RS16850 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C3K59_RS16855 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C3K59_RS16860 ENOG410635T phage-like element pbsx protein C3K59_RS16915 ENOG4108NF7 phage-type endonuclease C3K59_RS16920 ENOG4108PNI recT protein C3K59_RS17030 ENOG4107KNS C3K59_RS17170 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C3K59_RS17220 ENOG4105PGZ NB-ARC domain C3K59_RS17225 ENOG4105CPQ Dehydrogenase C3K59_RS17230 ENOG4105CT4 transporter C3K59_RS17240 ENOG41087YS Phage shock protein A C3K59_RS17245 ENOG4105DQX Zinc finger domain C3K59_RS17260 ENOG4108ZMR Ion transport 2 domain-containing protein C3K59_RS17265 ENOG4107QNK )-transporter C3K59_RS17295 ENOG4107YUH hydrolase C3K59_RS17305 ENOG4107STQ Multicopper oxidase C3K59_RS17310 ENOG4105C85 amino acid C3K59_RS17325 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C3K59_RS17355 ENOG4105C7N Xanthine uracil vitamin C permease C3K59_RS17380 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C3K59_RS17385 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C3K59_RS17390 ENOG4105C83 adenylosuccinate lyase C3K59_RS17395 ENOG4105C8V SAICAR synthetase C3K59_RS17400 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C3K59_RS17405 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I C3K59_RS17410 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C3K59_RS17420 ENOG4105CXB phosphoribosylaminoimidazole synthetase C3K59_RS17425 ENOG4108V3E phosphoribosylglycinamide formyltransferase C3K59_RS17430 ENOG4105DC1 bifunctional purine biosynthesis protein purh C3K59_RS17435 ENOG4105C12 Phosphoribosylglycinamide synthetase C3K59_RS17445 ENOG4105DVH amino acid C3K59_RS17460 ENOG4108R5T secreted protein C3K59_RS17465 ENOG4105KGF protein, YerC YecD C3K59_RS17470 ENOG4105CBC glutamate synthase C3K59_RS17475 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) C3K59_RS17480 ENOG4105C4R Atp-dependent dna helicase C3K59_RS17485 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C3K59_RS17495 ENOG4105CRN Aminoglycoside phosphotransferase C3K59_RS17505 ENOG4105CK7 Sodium proline symporter C3K59_RS17510 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C3K59_RS17515 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C3K59_RS17520 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C3K59_RS17525 ENOG4108IG5 Transcriptional regulator C3K59_RS17535 ENOG4105CBD Diacylglycerol kinase C3K59_RS17540 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C3K59_RS17590 ENOG4105CDY transcriptional regulatory protein C3K59_RS17600 ENOG4105M4P Tetr family transcriptional regulator C3K59_RS17605 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein C3K59_RS17610 ENOG4107S9F NmrA family C3K59_RS17625 ENOG4105WEF catalase C3K59_RS17630 ENOG4105M18 -acetyltransferase C3K59_RS17645 ENOG4105C2F Histidine kinase C3K59_RS17650 ENOG4105EQD regulatoR C3K59_RS17655 ENOG410769Z extracellular solute-binding protein family 1 C3K59_RS17660 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C3K59_RS17665 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component C3K59_RS17670 ENOG4105F5H Glycosyl Hydrolase Family 88 C3K59_RS17675 ENOG41075H3 AraC family transcriptional regulator C3K59_RS17680 ENOG4107TDE lipolytic protein G-D-S-L family C3K59_RS17695 ENOG4105CX8 fg-gap repeat protein C3K59_RS17700 ENOG4105CX8 fg-gap repeat protein C3K59_RS17705 ENOG4107TDE lipolytic protein G-D-S-L family C3K59_RS17715 ENOG4105EKC C3K59_RS17720 ENOG4105E0S extracellular solute-binding protein family 1 C3K59_RS17730 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C3K59_RS17735 ENOG4105F8D glycoside hydrolase family 4 C3K59_RS17740 ENOG4105H67 Protein of unknown function (DUF421) C3K59_RS17745 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) C3K59_RS17750 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C3K59_RS17770 ENOG4106I4J membrane C3K59_RS17775 ENOG4108PCN EamA-like transporter family C3K59_RS17780 ENOG41082F9 transcriptional regulator C3K59_RS17785 ENOG41061H0 Monooxygenase C3K59_RS17795 ENOG4108R1P C3K59_RS17800 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C3K59_RS17805 ENOG4105E0M Sulfatase C3K59_RS17810 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C3K59_RS17820 ENOG41090R9 glycosyltransferase C3K59_RS17825 ENOG4107R51 Glycosyl transferase, family 2 C3K59_RS17830 ENOG41090R9 glycosyltransferase C3K59_RS17835 ENOG4105EU0 Major facilitator Superfamily C3K59_RS17845 ENOG4105CUB amino acid C3K59_RS17850 ENOG4105C26 Dehydrogenase C3K59_RS17855 ENOG4105FKZ Methyl-accepting chemotaxis C3K59_RS17860 ENOG4105C5H ABC transporter C3K59_RS17870 ENOG4107SWG transcriptional regulator MERR family C3K59_RS17875 ENOG4105DXB Major Facilitator superfamily C3K59_RS17885 ENOG4105C5H ABC transporter C3K59_RS17890 ENOG4105FDU atp-dependent rna helicase C3K59_RS17900 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C3K59_RS17910 ENOG4105E6M Sulphatase-modifying factor protein C3K59_RS17915 ENOG4105E0A ABC, transporter C3K59_RS17920 ENOG4108U1V ABC transporter, permease C3K59_RS17925 ENOG4105DQ5 transport system permease protein C3K59_RS17930 ENOG4108HUF Transporter C3K59_RS17945 ENOG4108J20 pectate lyase C3K59_RS17950 ENOG4107QPK )-transporter C3K59_RS17960 ENOG4108MRH transcriptional regulatory protein C3K59_RS17985 ENOG410855V Acylphosphatase C3K59_RS17990 ENOG4108RPX mosc domain containing protein C3K59_RS18010 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C3K59_RS18040 ENOG4105GEU Spore germination protein C3K59_RS18050 ENOG4108Q5U germination protein, ger(x)c family C3K59_RS18055 ENOG4105E1K spore germination protein C3K59_RS18060 ENOG4105C5Y PTS System C3K59_RS18065 ENOG4105CG3 alpha amylase, catalytic region C3K59_RS18070 ENOG4107414 GntR family transcriptional regulator C3K59_RS18075 ENOG4108RCM Nitroreductase C3K59_RS18080 ENOG4105CGH 5'-nucleotidase C3K59_RS18085 ENOG4107RKG DJ-1/PfpI family C3K59_RS18110 ENOG4107U9T Pfam:Ribonuclease_BN C3K59_RS18115 ENOG4108ISG Major Facilitator C3K59_RS18120 ENOG4105UPD Calcium Proton C3K59_RS18130 ENOG4105D8X mechanosensitive ion channel C3K59_RS18150 ENOG4106KE4 Dehydrogenase C3K59_RS18155 ENOG4105D7N magnesium and cobalt transport protein CorA C3K59_RS18165 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C3K59_RS18185 ENOG4107RUY (E1 component), alpha subunit C3K59_RS18195 ENOG4107QKR Dehydrogenase C3K59_RS18205 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C3K59_RS18210 ENOG41069DP small acid-soluble spore protein C3K59_RS18215 ENOG4105KK4 UPF0060 membrane protein C3K59_RS18240 ENOG4105F8D glycoside hydrolase family 4 C3K59_RS18245 ENOG4108Q3X Transcriptional regulator C3K59_RS18250 ENOG4105CI1 PTS System C3K59_RS18255 ENOG4105BZ1 (ABC) transporter C3K59_RS18260 ENOG4105BZ1 (ABC) transporter C3K59_RS18275 ENOG4105BZU Histidine kinase C3K59_RS18280 ENOG4105WH1 Two component transcriptional regulator luxr family C3K59_RS18290 ENOG41090VJ ABC-2 type transporter C3K59_RS18295 ENOG4108KYE ABC-2 type transporter C3K59_RS18300 ENOG4105U3E Transcriptional regulator C3K59_RS18305 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C3K59_RS18310 ENOG4105H93 Acyltransferase family C3K59_RS18315 ENOG4108YYS metal-dependent hydrolase (By similarity) C3K59_RS18320 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3K59_RS18325 ENOG410834F Transcriptional regulator C3K59_RS18335 ENOG4108MES Periplasmic binding protein C3K59_RS18340 ENOG4105DQ5 transport system permease protein C3K59_RS18345 ENOG4108IHU transport system permease protein C3K59_RS18350 ENOG4105JAB phenazine biosynthesis protein, phzf family C3K59_RS18355 ENOG4107Y03 Nitroreductase C3K59_RS18370 ENOG4105ECP epimerase C3K59_RS18405 ENOG4106AKJ C3K59_RS18410 ENOG4105D74 hydrolase C3K59_RS18415 ENOG4105CKK Glycosyl transferase, family 2 C3K59_RS18420 ENOG4105EJV Membrane C3K59_RS18425 ENOG41067AE Membrane-bound metal-dependent hydrolase C3K59_RS18430 ENOG4105CEN a g-specific adenine glycosylase C3K59_RS18435 ENOG4106BXE C3K59_RS18440 ENOG4105CAN Short-chain dehydrogenase reductase Sdr C3K59_RS18455 ENOG4105EVI UPF0374 protein C3K59_RS18460 ENOG4105BZ1 (ABC) transporter C3K59_RS18465 ENOG4107NBY Membrane C3K59_RS18475 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C3K59_RS18480 ENOG4105G5W regulator Fur family C3K59_RS18590 ENOG4108N23 SpoOM-related protein C3K59_RS18605 ENOG4105EC3 peptidase S51, dipeptidase E C3K59_RS18610 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C3K59_RS18615 ENOG4105DNP FAD linked oxidase domain protein C3K59_RS18630 ENOG4105E2Y ABC, transporter C3K59_RS18635 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein C3K59_RS18640 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C3K59_RS18645 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C3K59_RS18655 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C3K59_RS18660 ENOG4107D63 C3K59_RS18665 ENOG4105VZ8 Transcriptional regulator C3K59_RS18680 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C3K59_RS18690 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C3K59_RS18710 ENOG4105CYN Serine protein kinase C3K59_RS18715 ENOG4106AKX UPF0229 protein C3K59_RS18720 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C3K59_RS18725 ENOG4105CW7 secretion protein, HlyD family C3K59_RS18735 ENOG4105CS1 NAD(P)H quinone oxidoreductase C3K59_RS18755 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C3K59_RS18760 ENOG4105CZV ABC transporter C3K59_RS18765 ENOG4105CJ1 ABC, transporter C3K59_RS18770 ENOG4108TU7 Inherit from COG: (ABC) transporter C3K59_RS18775 ENOG4105VEQ Cold shock protein C3K59_RS18785 ENOG4105BZU Histidine kinase C3K59_RS18825 ENOG4108YBP pseudouridine synthase C3K59_RS18835 ENOG41080XP Cbs domain C3K59_RS18840 ENOG4107YBY Hydrolase C3K59_RS18845 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C3K59_RS18850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3K59_RS18865 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C3K59_RS18870 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C3K59_RS18880 ENOG4105BZU Histidine kinase C3K59_RS18885 ENOG4105WH1 Two component transcriptional regulator luxr family C3K59_RS18920 ENOG4105ED1 spovr family C3K59_RS18925 ENOG4105G6Z alkaline phosphatase C3K59_RS18940 ENOG4105BZN citrate synthase C3K59_RS18945 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3K59_RS18950 ENOG4105CUB amino acid C3K59_RS18955 ENOG4105C8J )-transporter C3K59_RS18960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3K59_RS18975 ENOG4105J37 C3K59_RS18980 ENOG4108AEY RNA polymerase sigma factor C3K59_RS18990 ENOG4105F6E Acyl-transferase C3K59_RS18995 ENOG4105C37 (CBS) domain C3K59_RS19005 ENOG4105CHM Aminotransferase C3K59_RS19010 ENOG4105C37 (CBS) domain C3K59_RS19020 ENOG4105WMR Protein CrcB homolog C3K59_RS19025 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3K59_RS19035 ENOG4105D64 Mechanosensitive ion channel C3K59_RS19040 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C3K59_RS19045 ENOG4107VMI polysaccharide deacetylase C3K59_RS19050 ENOG4105F0I Aminotransferase C3K59_RS19070 ENOG4105BZ1 (ABC) transporter C3K59_RS19075 ENOG4105BZ1 (ABC) transporter C3K59_RS19100 ENOG410839P C3K59_RS19110 ENOG4106MP8 UPF0754 membrane protein C3K59_RS19115 ENOG4105WZB UPF0342 protein C3K59_RS19120 ENOG4105F1N DNA alkylation repair C3K59_RS19130 ENOG4105D4P Coproporphyrinogen iii oxidase C3K59_RS19135 ENOG4107S91 Sodium hydrogen exchanger C3K59_RS19140 ENOG4105NCW Trka-c domain protein C3K59_RS19150 ENOG4105CGU Enoyl-CoA hydratase C3K59_RS19160 ENOG4108IUX (ABC) transporter C3K59_RS19165 ENOG4105RHA ABC transporter, permease C3K59_RS19170 ENOG4107VRP DNA repair exonuclease C3K59_RS19175 ENOG4106D4I domain protein C3K59_RS19180 ENOG4105EQI Metal Dependent Phosphohydrolase C3K59_RS19190 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C3K59_RS19235 ENOG4105NBU tryptophan transport protein C3K59_RS19240 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C3K59_RS19245 ENOG4105K59 histidine triad (HIT) protein C3K59_RS19280 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C3K59_RS19285 ENOG4105BZ4 penicillin-binding protein C3K59_RS19290 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C3K59_RS19295 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C3K59_RS19300 ENOG4105C1Q protoporphyrinogen oxidase C3K59_RS19310 ENOG4105ECB domain protein C3K59_RS19320 ENOG41090T1 Membrane C3K59_RS19330 ENOG4105DER m42 family C3K59_RS19345 ENOG4106AXD C3K59_RS19350 ENOG4108RQ5 Beta-lactamase domain-containing protein C3K59_RS19355 ENOG4105DF9 Lipoate-protein, ligase C3K59_RS19365 ENOG4105CEY Amp-dependent synthetase and ligase C3K59_RS19375 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C3K59_RS19380 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C3K59_RS19385 ENOG4105KD7 acetyltransferase C3K59_RS19395 ENOG4108HUF Transporter C3K59_RS19400 ENOG4107TB6 phosphoglycerate mutase C3K59_RS19410 ENOG4107F3J Amp-dependent synthetase and ligase C3K59_RS19415 ENOG4107ZYJ bioY protein C3K59_RS19420 ENOG4106YBV Methyl-accepting chemotaxis C3K59_RS19440 ENOG4105XVF Competence transcription factor C3K59_RS19445 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3K59_RS19450 ENOG4105X3H Excalibur domain protein C3K59_RS19455 ENOG4105E1V na solute symporter C3K59_RS19460 ENOG4106CAD Protein of unknown function (DUF3311) C3K59_RS19465 ENOG41060YP C3K59_RS19480 ENOG4107SCK Monooxygenase C3K59_RS19500 ENOG4105TRI Hydrolase C3K59_RS19515 ENOG4108KK1 membrane protein AbrB duplication C3K59_RS19520 ENOG4106K7D Major facilitator family transporter C3K59_RS19525 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) C3K59_RS19530 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding C3K59_RS19555 ENOG4105EYH Exonuclease C3K59_RS19605 ENOG4105ERH Fumarylacetoacetate hydrolase C3K59_RS19615 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C3K59_RS19640 ENOG4105UQX Mate efflux family protein C3K59_RS19645 ENOG4106HBX Transcriptional Regulator AraC Family C3K59_RS19650 ENOG4105ETE Transcriptional regulator (LacI family C3K59_RS19655 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C3K59_RS19660 ENOG4105SF0 DinB family C3K59_RS19665 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C3K59_RS19670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3K59_RS19675 ENOG4105MYW Pentapeptide repeat protein C3K59_RS19680 ENOG4107S9D Alpha beta hydrolase C3K59_RS19685 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C3K59_RS19690 ENOG4107RIQ Sulfate adenylate transferase C3K59_RS19695 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C3K59_RS19700 ENOG4108N5B 2-phosphosulfolactate phosphatase C3K59_RS19705 ENOG41061P3 phosphosulfolactate synthase C3K59_RS19715 ENOG4105DIA mandelate racemase muconate lactonizing C3K59_RS19720 ENOG4107RCC Major Facilitator Superfamily C3K59_RS19725 ENOG4108SZE gCN5-related N-acetyltransferase C3K59_RS19730 ENOG4105MA6 gCN5-related N-acetyltransferase C3K59_RS19740 ENOG4108VPT UPF0234 protein C3K59_RS19745 ENOG4105QNR S1 RNA binding domain protein C3K59_RS19765 ENOG4105K7K Transcriptional regulator C3K59_RS19775 ENOG410751J C3K59_RS19780 ENOG4105D4Y metalloprotease C3K59_RS19785 ENOG4105EPR degv family C3K59_RS19790 ENOG4107AYK membrAne C3K59_RS19800 ENOG41073B9 C3K59_RS19810 ENOG4108KP7 hydrolase C3K59_RS19815 ENOG4108MXZ Esterase C3K59_RS19820 ENOG4105VG1 fes assembly suf system protein C3K59_RS19830 ENOG4105IQ5 FAD linked oxidase domain protein C3K59_RS19840 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C3K59_RS19845 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C3K59_RS19855 ENOG4105C8Y Acetylornithine aminotransferase C3K59_RS19860 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C3K59_RS19870 ENOG4105DBV ornithine carbamoyltransferase C3K59_RS19895 ENOG4107RMD Basic membrane lipoprotein C3K59_RS19910 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C3K59_RS19915 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C3K59_RS19925 ENOG4105C3U ABC transporter C3K59_RS19930 ENOG4108JQ7 (ABC) transporter C3K59_RS19955 ENOG4105C31 Tryptophanyl-tRNA synthetase C3K59_RS19960 ENOG4108J59 Extracellular solute-binding protein, family 5 C3K59_RS19965 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3K59_RS19970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K59_RS19980 ENOG4108JQ7 (ABC) transporter C3K59_RS19995 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C3K59_RS20000 ENOG4108ZCF integral membrane protein C3K59_RS20010 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis C3K59_RS20025 ENOG4105DPN Oligoendopeptidase f C3K59_RS20035 ENOG4105T58 Dithiol-disulfide isomerase C3K59_RS20040 ENOG4108Z18 K06886 hemoglobin C3K59_RS20045 ENOG4105E4C Lytic transglycosylase catalytic C3K59_RS20050 ENOG4105MIX Adenylate cyclase C3K59_RS20065 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C3K59_RS20070 ENOG4105EMS pseudouridine synthase C3K59_RS20085 ENOG4105ETU transcriptional activator (TenA C3K59_RS20105 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C3K59_RS20110 ENOG4105D06 uba thif-type nad fad binding protein C3K59_RS20115 ENOG4105DWF phosphomethylpyrimidine kinase C3K59_RS20120 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C3K59_RS20125 ENOG4107A88 C3K59_RS20175 ENOG4105ENA helicase C3K59_RS20190 ENOG4108ZMI UPF0477 protein C3K59_RS20200 ENOG4105C28 cystathionine C3K59_RS20205 ENOG4105C28 cystathionine C3K59_RS20210 ENOG4105D9U N-acetyltransferase C3K59_RS20215 ENOG4105JHY Membrane C3K59_RS20235 ENOG4106BHF C3K59_RS20290 ENOG4108PSK reductase C3K59_RS20310 ENOG4105DG6 mannose-6-phosphate isomerase C3K59_RS20315 ENOG4105G7B Protein of unknown function (DUF2992) C3K59_RS20320 ENOG4105VMI -acetyltransferase C3K59_RS20330 ENOG4108Z66 YbaK ebsC protein C3K59_RS20345 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C3K59_RS20355 ENOG4108ZJ4 polysaccharide deacetylase C3K59_RS20360 ENOG4107CUJ Protein of unknown function (DUF2690) C3K59_RS20385 ENOG4108IEG Formate dehydrogenase Alpha subunit C3K59_RS20410 ENOG4106A3M Cytochrome p-450 C3K59_RS20415 ENOG41087PP glycosyltransferase MGT family C3K59_RS20425 ENOG4105EXQ uroporphyrinogen iii synthase hem4 C3K59_RS20430 ENOG4105C4B ABC transporter, permease C3K59_RS20435 ENOG4108IXI (ABC) transporter C3K59_RS20445 ENOG4105Q95 Cupin 2, conserved barrel domain protein C3K59_RS20460 ENOG4105D2H Uronic isomerase C3K59_RS20465 ENOG4105CT4 transporter C3K59_RS20475 ENOG4105CPQ Dehydrogenase C3K59_RS20480 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) C3K59_RS20485 ENOG4105DMW Dehydrogenase reductase C3K59_RS20495 ENOG4107KJX Transcriptional regulator C3K59_RS20505 ENOG4105CTX dehydratase C3K59_RS20510 ENOG4107TSN permease C3K59_RS20520 ENOG4105JD4 ATPase yjob C3K59_RS20535 ENOG41068K0 YCII-related domain C3K59_RS20540 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C3K59_RS20545 ENOG4105KWG Pfam:DUF1696 C3K59_RS20550 ENOG4105K7W phage-related replication protein C3K59_RS20555 ENOG4105WEF catalase C3K59_RS20560 ENOG410635T phage-like element pbsx protein C3K59_RS20605 ENOG4108TFU terminase (Small subunit) C3K59_RS20610 ENOG4105IG6 Phage terminase, large subunit C3K59_RS20615 ENOG4108MDF Phage Portal Protein C3K59_RS20640 ENOG41060SN C3K59_RS20655 ENOG4105PQS phage protein C3K59_RS20660 ENOG4105FR7 XkdM protein, phage-like element PBSX C3K59_RS20665 ENOG4105MTC XkdN-like protein C3K59_RS20675 ENOG4108FKH Transglycosylase SLT domain C3K59_RS20675 ENOG4108FKH Transglycosylase SLT domain C3K59_RS20680 ENOG4108WZM domain protein C3K59_RS20685 ENOG4105X7F C3K59_RS20695 ENOG4105MFU Protein of unknown function (DUF2634) C3K59_RS20700 ENOG41066EA baseplate J family protein C3K59_RS20705 ENOG410906S phage-like element pbsx protein xkdt C3K59_RS20745 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C3K59_RS20765 ENOG4105CJ3 phosphate transporter C3K59_RS20770 ENOG4107GRR phosphate transport regulator C3K59_RS20775 ENOG4107R7I amino acid C3K59_RS20785 ENOG4105EDW glycosyl transferase, family 39 C3K59_RS20790 ENOG4105CKK Glycosyl transferase, family 2 C3K59_RS20800 ENOG4105C0H protease C3K59_RS20810 ENOG4108ME1 Peptidase M55 D-aminopeptidase C3K59_RS20815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3K59_RS20820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3K59_RS20825 ENOG4105C3U ABC transporter C3K59_RS20840 ENOG4105DTQ mandelate racemase muconate lactonizing C3K59_RS20850 ENOG4108JQ7 (ABC) transporter C3K59_RS20855 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C3K59_RS20860 ENOG4107TUM Amidinotransferase C3K59_RS20865 ENOG4108S4H thioesterase Superfamily protein C3K59_RS20870 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C3K59_RS20890 ENOG4108428 Inherit from COG: -acetyltransferase C3K59_RS20900 ENOG41080TC multidrug resistance protein C3K59_RS20905 ENOG4105CIY formyltetrahydrofolate deformylase C3K59_RS20910 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C3K59_RS20925 ENOG4105K56 Transcriptional regulator C3K59_RS20930 ENOG4108ZHJ Organic hydroperoxide resistance protein C3K59_RS20940 ENOG4107Y2X deaminase C3K59_RS20945 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C3K59_RS20950 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C3K59_RS20960 ENOG4108W7F transporter, permease C3K59_RS20965 ENOG4108JJB ABC transporter C3K59_RS20970 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein C3K59_RS20975 ENOG4108X43 YKOF domain protein C3K59_RS20980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3K59_RS20985 ENOG41062D9 Histidine kinase C3K59_RS20995 ENOG4106849 propeptide, pepSY amd peptidase M4 C3K59_RS21005 ENOG4105CJW magnesium transporter C3K59_RS21055 ENOG4105DQE DNA ligase C3K59_RS21060 ENOG4105FDF Could be involved in DNA repair (By similarity) C3K59_RS21065 ENOG4105BZU Histidine kinase C3K59_RS21070 ENOG4107T5V SNARE associated Golgi C3K59_RS21075 ENOG4107TS3 membrane protein, TerC C3K59_RS21080 ENOG4108WZW RNA polymerase sigma C3K59_RS21090 ENOG410681C small acid-soluble spore protein C3K59_RS21100 ENOG4105D0M Protease HtpX homolog C3K59_RS21120 ENOG4108TGC Acyltransferase C3K59_RS21125 ENOG4105BZU Histidine kinase C3K59_RS21130 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C3K59_RS21140 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C3K59_RS21145 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) C3K59_RS21150 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C3K59_RS21170 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C3K59_RS21175 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C3K59_RS21195 ENOG4105BZU Histidine kinase C3K59_RS21200 ENOG41090MY MarR family Transcriptional regulator C3K59_RS21205 ENOG4105ER2 Ompa motb domain protein C3K59_RS21210 ENOG4105E14 MotA TolQ exbB proton channel C3K59_RS21220 ENOG4108K88 Membrane C3K59_RS21225 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C3K59_RS21230 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase C3K59_RS21235 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C3K59_RS21240 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C3K59_RS21250 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C3K59_RS21285 ENOG4105F0V Cell wall hydrolase C3K59_RS21300 ENOG4105C59 p-type ATPase C3K59_RS21310 ENOG4105DC7 peptidase M24 C3K59_RS21320 ENOG4105CID antiterminator C3K59_RS21330 ENOG4105KRI phosphocarrier protein (HPr C3K59_RS21335 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C3K59_RS21345 ENOG4105F6S Spore photoproduct lyase C3K59_RS21355 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C3K59_RS21360 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C3K59_RS21365 ENOG4105K4I Scp-like extracellular C3K59_RS21375 ENOG4105BZU Histidine kinase C3K59_RS21380 ENOG4105CHM Aminotransferase C3K59_RS21390 ENOG4107R88 Chemotaxis protein (CheV) C3K59_RS21395 ENOG4105UIN C3K59_RS21405 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein C3K59_RS21415 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C3K59_RS21420 ENOG4105EPM Diguanylate phosphodiesterase C3K59_RS21425 ENOG4107IN1 Protein of unknown function (DUF1797) C3K59_RS21460 ENOG4105NQC Flavodoxin C3K59_RS21470 ENOG4105CH2 amidohydrolase C3K59_RS21480 ENOG4105D8X mechanosensitive ion channel C3K59_RS21485 ENOG4105D3R alkyl hydroperoxide reductase C3K59_RS21490 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C3K59_RS21505 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C3K59_RS21515 ENOG4105CVM Molybdenum cofactor synthesis domain protein C3K59_RS21520 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C3K59_RS21525 ENOG4108ZAF Molybdopterin C3K59_RS21530 ENOG41067WU Molybdopterin converting factor (Subunit 1) C3K59_RS21535 ENOG4105BZ1 (ABC) transporter C3K59_RS21540 ENOG4105BZ1 (ABC) transporter C3K59_RS21550 ENOG4107X8C Efflux transporter RND family MFP subunit C3K59_RS21555 ENOG4105C19 ABC transporter C3K59_RS21560 ENOG4107RBB ABC transporter, permease C3K59_RS21580 ENOG4105C3F Signal peptidase i C3K59_RS21590 ENOG4105C5H ABC transporter C3K59_RS21595 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C3K59_RS21620 ENOG4105BZU Histidine kinase C3K59_RS21630 ENOG4107ZYR domain protein C3K59_RS21640 ENOG4105CN5 Metallo-Beta-Lactamase C3K59_RS21650 ENOG4108X4Q Hydrolase C3K59_RS21655 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C3K59_RS21675 ENOG4105CPP Dehydrogenase, E1 component C3K59_RS21680 ENOG4105C7S Dehydrogenase C3K59_RS21685 ENOG4107QN2 dihydrolipoyl dehydrogenase C3K59_RS21700 ENOG4105CXN decarboxylase C3K59_RS21705 ENOG4105WBI UPF0223 protein C3K59_RS21720 ENOG4105ECY inositol monophosphatase C3K59_RS21730 ENOG4105JQZ Methyltransferase C3K59_RS21775 ENOG4105QA2 C3K59_RS21790 ENOG4108IAB Phoh family C3K59_RS21800 ENOG4105CSV Glutaminase C3K59_RS21805 ENOG4105ZPI UPF0358 protein C3K59_RS21810 ENOG4105CNI cell division protein FtsW C3K59_RS21815 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C3K59_RS21825 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C3K59_RS21835 ENOG4105BZ9 Cytochrome C oxidase, subunit I C3K59_RS21840 ENOG4105CCU oxidase (Subunit III) C3K59_RS21845 ENOG41064X9 cytochrome C oxidase subunit IV C3K59_RS21860 ENOG41080XQ Signal transduction protein with cbs domains C3K59_RS21865 ENOG4106UY4 Inherit from COG: Scp-like extracellular C3K59_RS21885 ENOG4105WUC UPF0298 protein C3K59_RS21895 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C3K59_RS21900 ENOG4105H20 Sporulation integral membrane protein YlbJ C3K59_RS21905 ENOG4105D78 K07001 NTE family protein C3K59_RS21910 ENOG41063PX domain protein C3K59_RS21925 ENOG4105KNH Nucleic acid-binding protein C3K59_RS21955 ENOG4108V6E Cell division protein mraZ C3K59_RS21960 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C3K59_RS21970 ENOG4105CJN penicillin-binding protein C3K59_RS21975 ENOG4105CJN penicillin-binding protein C3K59_RS21980 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C3K59_RS21985 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C3K59_RS21990 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C3K59_RS21995 ENOG4105CNI cell division protein FtsW C3K59_RS22000 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C3K59_RS22005 ENOG4105D4A Cell wall formation (By similarity) C3K59_RS22010 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) C3K59_RS22015 ENOG4108R2U division initiation protein C3K59_RS22025 ENOG4105K67 small basic protein C3K59_RS22030 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C3K59_RS22035 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C3K59_RS22050 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K59_RS22060 ENOG4105DKW ABC transporter C3K59_RS22070 ENOG4105WR5 sporulation protein, YlmC YmxH family C3K59_RS22075 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C3K59_RS22080 ENOG4105DFA alanine racemase domain protein C3K59_RS22085 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C3K59_RS22090 ENOG41067XK integral membrane protein C3K59_RS22105 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C3K59_RS22115 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C3K59_RS22120 ENOG4105C34 Pseudouridine synthase C3K59_RS22125 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C3K59_RS22135 ENOG4105CXT aspartate transcarbamylase C3K59_RS22145 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C3K59_RS22150 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C3K59_RS22155 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C3K59_RS22165 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C3K59_RS22170 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C3K59_RS22175 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C3K59_RS22185 ENOG4107S4M Sulfate adenylate transferase C3K59_RS22190 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C3K59_RS22200 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C3K59_RS22205 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C3K59_RS22220 ENOG4105DSJ YicC domain protein C3K59_RS22225 ENOG4105KC4 UPF0296 protein C3K59_RS22230 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C3K59_RS22240 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C3K59_RS22245 ENOG4105C25 Primosomal protein n' C3K59_RS22250 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C3K59_RS22255 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C3K59_RS22260 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C3K59_RS22265 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C3K59_RS22270 ENOG4108ZF3 Phosphatase C3K59_RS22275 ENOG4105D9P serine threonine protein kinase C3K59_RS22280 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C3K59_RS22285 ENOG4105DJV ribulose-phosphate 3-epimerase C3K59_RS22290 ENOG4105FJ0 thiamine C3K59_RS22300 ENOG4105VB9 50S ribosomal protein l28 C3K59_RS22305 ENOG4108ZAA Alkaline-shock protein C3K59_RS22310 ENOG4105DP4 dak2 domain fusion protein ylov C3K59_RS22320 ENOG4105EJQ L-serine dehydratase C3K59_RS22325 ENOG4105CB5 ATP-dependent DNA helicase recG C3K59_RS22330 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) C3K59_RS22340 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C3K59_RS22345 ENOG4105CHR reductase C3K59_RS22355 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C3K59_RS22360 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C3K59_RS22365 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C3K59_RS22375 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) C3K59_RS22385 ENOG4105K5M 30s ribosomal protein S16 C3K59_RS22390 ENOG4108BW8 UPF0109 protein C3K59_RS22400 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C3K59_RS22405 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C3K59_RS22410 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C3K59_RS22415 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C3K59_RS22420 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C3K59_RS22430 ENOG4105VM1 flagellar C3K59_RS22440 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C3K59_RS22450 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C3K59_RS22455 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) C3K59_RS22460 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C3K59_RS22465 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C3K59_RS22470 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C3K59_RS22480 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C3K59_RS22485 ENOG4108ZC9 flagellar basal-body rod protein flgc C3K59_RS22490 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C3K59_RS22495 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C3K59_RS22500 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C3K59_RS22515 ENOG4106YF4 Flagellar biosynthesis chaperone C3K59_RS22525 ENOG410696Y Flagellar hook-length control protein C3K59_RS22530 ENOG410822I Flagellar hook capping protein C3K59_RS22535 ENOG4108JQA flagellar C3K59_RS22540 ENOG41068WV flagellar FlbD family protein C3K59_RS22550 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C3K59_RS22555 ENOG4105DD5 Flagellar motor switch protein C3K59_RS22560 ENOG4107YTP response regulator receiver protein C3K59_RS22570 ENOG4105CN7 Flagellar biosynthetic protein FliP C3K59_RS22575 ENOG4105VS8 Flagellar biosynthetic protein fliq C3K59_RS22580 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C3K59_RS22585 ENOG4105D00 flagellar biosynthetic protein flhB C3K59_RS22590 ENOG4105D7B Flagellar biosynthesis protein flha C3K59_RS22595 ENOG4105FZW flagellar biosynthesis regulator FlhF C3K59_RS22605 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C3K59_RS22610 ENOG4105CBS Chea signal transduction histidine kinase C3K59_RS22615 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis C3K59_RS22630 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3K59_RS22640 ENOG4105CE9 30S ribosomal protein S2 C3K59_RS22645 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C3K59_RS22655 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C3K59_RS22660 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C3K59_RS22665 ENOG4105KNE Phosphatidate cytidylyltransferase C3K59_RS22675 ENOG4105DZP Membrane-associated zinc metalloprotease C3K59_RS22680 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C3K59_RS22685 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C3K59_RS22690 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C3K59_RS22695 ENOG4105CHV Transcription elongation factor NusA C3K59_RS22700 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C3K59_RS22705 ENOG4105VHM ribosomal protein C3K59_RS22710 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C3K59_RS22715 ENOG4105W7A Protein of unknown function (DUF503) C3K59_RS22720 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C3K59_RS22725 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C3K59_RS22730 ENOG4105DTN riboflavin biosynthesis protein ribF C3K59_RS22735 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C3K59_RS22740 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C3K59_RS22750 ENOG4105C1V Peptidase, M16 C3K59_RS22760 ENOG4105E35 Dipicolinate synthase subunit A C3K59_RS22765 ENOG4108S0H Dipicolinic acid synthetase, b subunit C3K59_RS22770 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C3K59_RS22780 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C3K59_RS22790 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C3K59_RS22800 ENOG4105CNU cell division protein FtsK C3K59_RS22805 ENOG4105FDP GntR family transcriptional regulator C3K59_RS22825 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C3K59_RS22830 ENOG4105XZV Protein of unknown function (DUF3243) C3K59_RS22845 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C3K59_RS22850 ENOG4105CEV competence damage-inducible protein C3K59_RS22860 ENOG4108A04 Beta-lactamase C3K59_RS22865 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) C3K59_RS22870 ENOG4105D48 metallophosphoesterase C3K59_RS22875 ENOG4105MCT stage V sporulation protein S C3K59_RS22885 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C3K59_RS22890 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C3K59_RS22905 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C3K59_RS22910 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C3K59_RS22920 ENOG4105IIP Membrane C3K59_RS22925 ENOG4105W1N transcriptional regulator C3K59_RS22930 ENOG4108151 Beta-lactamase domain protein C3K59_RS22940 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C3K59_RS22950 ENOG4107QKG PfaD family C3K59_RS22955 ENOG41062T2 Acyl carrier protein C3K59_RS22960 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase C3K59_RS22965 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase C3K59_RS22970 ENOG4108MGH Enoyl-CoA hydratase C3K59_RS22975 ENOG4108KQ6 Enoyl-CoA hydratase C3K59_RS22995 ENOG4105C0W non-ribosomal peptide synthetase