locus-tag	class	description
C3K59_RS00040	COG1764	response to oxidative stress
C3K59_RS00045	COG2076	Multidrug Resistance protein
C3K59_RS00065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3K59_RS00070	COG1923	regulation of RNA biosynthetic process
C3K59_RS00085	COG1780	Probably involved in ribonucleotide reductase function
C3K59_RS00090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3K59_RS00095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3K59_RS00100	COG4112	unkown
C3K59_RS00105	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS00110	COG0464	growth
C3K59_RS00125	COG1525	nuclease
C3K59_RS00135	COG4282	regulation of fungal-type cell wall biogenesis
C3K59_RS00140	COG5444	nuclease activity
C3K59_RS00170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3K59_RS00180	COG0457	Tetratricopeptide repeat
C3K59_RS00195	COG5632	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS00205	COG5434	Belongs to the glycosyl hydrolase 28 family
C3K59_RS00225	COG0739	heme binding
C3K59_RS00225	COG1196	nuclear chromosome segregation
C3K59_RS00225	COG0741	lytic transglycosylase activity
C3K59_RS00265	COG0584	glycerophosphoryl diester phosphodiesterase
C3K59_RS00355	COG4373	Mu-like prophage FluMu protein gp28
C3K59_RS00400	COG0776	regulation of translation
C3K59_RS00530	COG0582	viral genome integration into host DNA
C3K59_RS00545	COG3655	Transcriptional regulator
C3K59_RS00620	COG4474	Belongs to the UPF0398 family
C3K59_RS00650	COG1793	dna ligase
C3K59_RS00655	COG2135	peptidase activity
C3K59_RS00685	COG3420	alginic acid biosynthetic process
C3K59_RS00685	COG5434	Belongs to the glycosyl hydrolase 28 family
C3K59_RS00720	COG0305	Participates in initiation and elongation during chromosome replication
C3K59_RS00725	COG0358	DNA primase activity
C3K59_RS00730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C3K59_RS00735	COG0587	DNA-directed DNA polymerase activity
C3K59_RS00765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3K59_RS00770	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
C3K59_RS00780	COG0270	DNA (cytosine-5-)-methyltransferase activity
C3K59_RS00880	COG1780	Probably involved in ribonucleotide reductase function
C3K59_RS00885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3K59_RS00885	COG1372	Participates in initiation and elongation during chromosome replication
C3K59_RS00910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS00935	COG0756	dUTP diphosphatase activity
C3K59_RS00965	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3K59_RS01045	COG3331	DNA recombination
C3K59_RS01065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3K59_RS01070	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C3K59_RS01075	COG0789	Transcriptional regulator
C3K59_RS01080	COG0174	glutamine synthetase
C3K59_RS01115	COG0463	Glycosyl transferase, family 2
C3K59_RS01135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K59_RS01150	COG3655	Transcriptional regulator
C3K59_RS01165	COG0135	phosphoribosylanthranilate isomerase activity
C3K59_RS01185	COG3507	Belongs to the glycosyl hydrolase 43 family
C3K59_RS01190	COG1940	carbohydrate kinase activity
C3K59_RS01195	COG2115	Belongs to the xylose isomerase family
C3K59_RS01210	COG1525	nuclease
C3K59_RS01215	COG2814	Major facilitator Superfamily
C3K59_RS01220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3K59_RS01230	COG0756	dUTP diphosphatase activity
C3K59_RS01270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3K59_RS01295	COG0697	spore germination
C3K59_RS01330	COG4195	phage-related replication protein
C3K59_RS01345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3K59_RS01350	COG1388	LysM domain
C3K59_RS01355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3K59_RS01360	COG4224	UPF0291 protein
C3K59_RS01365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C3K59_RS01375	COG3763	UPF0154 protein
C3K59_RS01385	COG0785	Cytochrome C biogenesis protein
C3K59_RS01390	COG2201	protein-glutamate methylesterase activity
C3K59_RS01395	COG4846	Membrane protein involved in cytochrome C biogenesis
C3K59_RS01405	COG0071	Belongs to the small heat shock protein (HSP20) family
C3K59_RS01420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3K59_RS01425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS01445	COG0824	Thioesterase
C3K59_RS01455	COG4841	protein insertion into membrane
C3K59_RS01460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C3K59_RS01465	COG1832	CoA-binding protein
C3K59_RS01470	COG0187	DNA topoisomerase II activity
C3K59_RS01475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3K59_RS01485	COG1115	amino acid carrier protein
C3K59_RS01500	COG5520	Belongs to the glycosyl hydrolase 30 family
C3K59_RS01505	COG3507	Belongs to the glycosyl hydrolase 43 family
C3K59_RS01510	COG2246	polysaccharide biosynthetic process
C3K59_RS01515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3K59_RS01520	COG0586	Pfam SNARE associated Golgi protein
C3K59_RS01525	COG2404	hydrolase activity, acting on ester bonds
C3K59_RS01530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3K59_RS01535	COG1024	Enoyl-CoA hydratase
C3K59_RS01540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3K59_RS01545	COG0511	ligase activity, forming carbon-carbon bonds
C3K59_RS01550	COG0439	Biotin carboxylase
C3K59_RS01555	COG0318	PFAM AMP-dependent synthetase and ligase
C3K59_RS01560	COG1960	acyl-CoA dehydrogenase activity
C3K59_RS01575	COG1649	PFAM Uncharacterised BCR, COG1649
C3K59_RS01585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS01585	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C3K59_RS01590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS01595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS01605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS01620	COG2027	D-alanyl-D-alanine carboxypeptidase
C3K59_RS01625	COG2017	converts alpha-aldose to the beta-anomer
C3K59_RS01630	COG0534	Mate efflux family protein
C3K59_RS01645	COG0582	viral genome integration into host DNA
C3K59_RS01650	COG0166	Belongs to the GPI family
C3K59_RS01655	COG0405	Gamma-glutamyltransferase
C3K59_RS01665	COG0604	alcohol dehydrogenase
C3K59_RS01670	COG0493	'glutamate synthase
C3K59_RS01675	COG0069	glutamate synthase activity
C3K59_RS01675	COG0067	glutamate synthase
C3K59_RS01675	COG0070	glutamate synthase
C3K59_RS01680	COG0583	DNA-binding transcription factor activity
C3K59_RS01685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3K59_RS01690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3K59_RS01700	COG0300	oxidoreductase activity
C3K59_RS01705	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C3K59_RS01720	COG2814	Major facilitator Superfamily
C3K59_RS01725	COG1070	Carbohydrate kinase
C3K59_RS01730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3K59_RS01735	COG0243	molybdopterin cofactor binding
C3K59_RS01765	COG0840	transmembrane signaling receptor activity
C3K59_RS01765	COG5278	phosphoserine phosphatase activity
C3K59_RS01770	COG2368	4-hydroxyphenylacetate
C3K59_RS01775	COG4305	rare lipoprotein A
C3K59_RS01780	COG3619	membrane
C3K59_RS01785	COG3866	Pectate lyase
C3K59_RS01790	COG2135	peptidase activity
C3K59_RS01800	COG2140	Oxalate decarboxylase
C3K59_RS01840	COG3655	Transcriptional regulator
C3K59_RS01845	COG3739	integral membrane protein
C3K59_RS01850	COG0583	DNA-binding transcription factor activity
C3K59_RS01865	COG0693	protein deglycase activity
C3K59_RS01870	COG2367	Beta-lactamase
C3K59_RS01895	COG0726	polysaccharide deacetylase
C3K59_RS01930	COG4282	regulation of fungal-type cell wall biogenesis
C3K59_RS01935	COG1231	oxidoreductase activity
C3K59_RS01940	COG5434	Belongs to the glycosyl hydrolase 28 family
C3K59_RS01945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3K59_RS01950	COG2207	Transcriptional regulator
C3K59_RS01950	COG0662	Cupin 2, conserved barrel domain protein
C3K59_RS01955	COG0456	acetyltransferase
C3K59_RS01965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3K59_RS01970	COG3708	Transcriptional regulator
C3K59_RS01985	COG0640	Transcriptional regulator
C3K59_RS01990	COG0741	lytic transglycosylase activity
C3K59_RS01995	COG2322	membrane
C3K59_RS02010	COG1619	proteins homologs of microcin C7 resistance protein MccF
C3K59_RS02015	COG3239	Fatty acid desaturase
C3K59_RS02020	COG4585	Histidine kinase
C3K59_RS02025	COG2197	response regulator
C3K59_RS02030	COG3584	3D domain protein
C3K59_RS02030	COG1388	LysM domain
C3K59_RS02035	COG0514	ATP-dependent DNA helicase (RecQ)
C3K59_RS02045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3K59_RS02065	COG0071	Belongs to the small heat shock protein (HSP20) family
C3K59_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS02100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3K59_RS02105	COG0733	neurotransmitter:sodium symporter activity
C3K59_RS02110	COG0385	Bile acid
C3K59_RS02115	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3K59_RS02120	COG0567	Dehydrogenase, E1 component
C3K59_RS02125	COG4548	von Willebrand factor, type A
C3K59_RS02130	COG0714	Associated with various cellular activities
C3K59_RS02135	COG2032	superoxide dismutase activity
C3K59_RS02140	COG0791	NLP P60 protein
C3K59_RS02140	COG1388	LysM domain
C3K59_RS02145	COG1819	glycosyl
C3K59_RS02150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C3K59_RS02155	COG0534	Mate efflux family protein
C3K59_RS02160	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K59_RS02165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3K59_RS02170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3K59_RS02180	COG2962	Rard protein
C3K59_RS02195	COG2610	gluconate transmembrane transporter activity
C3K59_RS02200	COG1942	4-Oxalocrotonate Tautomerase
C3K59_RS02205	COG1733	regulation of RNA biosynthetic process
C3K59_RS02210	COG0778	Nitroreductase
C3K59_RS02215	COG0400	carboxylic ester hydrolase activity
C3K59_RS02220	COG0346	lactoylglutathione lyase activity
C3K59_RS02230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3K59_RS02235	COG0793	Belongs to the peptidase S41A family
C3K59_RS02235	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS02240	COG2226	methyltransferase
C3K59_RS02250	COG1876	peptidase activity
C3K59_RS02255	COG0813	purine-nucleoside phosphorylase activity
C3K59_RS02270	COG0671	phosphoesterase, PA-phosphatase related
C3K59_RS02290	COG4479	Belongs to the UPF0346 family
C3K59_RS02300	COG1509	lysine 2,3-aminomutase activity
C3K59_RS02305	COG0456	acetyltransferase
C3K59_RS02310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3K59_RS02315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C3K59_RS02325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3K59_RS02340	COG0456	acetyltransferase
C3K59_RS02345	COG0463	Glycosyl transferase, family 2
C3K59_RS02360	COG4641	Protein conserved in bacteria
C3K59_RS02365	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C3K59_RS02370	COG1086	Polysaccharide biosynthesis protein
C3K59_RS02375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3K59_RS02380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3K59_RS02385	COG1846	Transcriptional regulator
C3K59_RS02390	COG0534	Mate efflux family protein
C3K59_RS02405	COG2755	lipolytic protein G-D-S-L family
C3K59_RS02410	COG1999	signal sequence binding
C3K59_RS02420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3K59_RS02425	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3K59_RS02430	COG1272	protein, Hemolysin III
C3K59_RS02435	COG0204	Acyl-transferase
C3K59_RS02440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3K59_RS02445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C3K59_RS02450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C3K59_RS02460	COG2136	Putative SAM-dependent methyltransferase
C3K59_RS02460	COG2521	methyltransferase
C3K59_RS02470	COG0129	dihydroxy-acid dehydratase activity
C3K59_RS02475	COG1413	lyase activity
C3K59_RS02485	COG0386	Belongs to the glutathione peroxidase family
C3K59_RS02490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C3K59_RS02495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3K59_RS02505	COG1278	Cold shock
C3K59_RS02525	COG0328	RNA-DNA hybrid ribonuclease activity
C3K59_RS02530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C3K59_RS02535	COG0328	RNA-DNA hybrid ribonuclease activity
C3K59_RS02545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3K59_RS02560	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C3K59_RS02570	COG1755	Isoprenylcysteine carboxyl methyltransferase
C3K59_RS02575	COG3424	synthase
C3K59_RS02585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3K59_RS02590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C3K59_RS02600	COG0800	Aldolase
C3K59_RS02605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3K59_RS02610	COG1609	Transcriptional regulator
C3K59_RS02615	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C3K59_RS02625	COG1199	ATP-dependent helicase activity
C3K59_RS02640	COG0116	Belongs to the methyltransferase superfamily
C3K59_RS02655	COG4474	Belongs to the UPF0398 family
C3K59_RS02675	COG1111	helicase
C3K59_RS02675	COG1205	dead DEAH box helicase
C3K59_RS02680	COG2190	(PTS) system
C3K59_RS02685	COG0071	Belongs to the small heat shock protein (HSP20) family
C3K59_RS02720	COG3331	DNA recombination
C3K59_RS02725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3K59_RS02725	COG4499	WXG100 protein secretion system (Wss), protein YukC
C3K59_RS02735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C3K59_RS02740	COG3935	DnaD domain protein
C3K59_RS02745	COG0017	Asparaginyl-tRNA synthetase
C3K59_RS02750	COG0436	Aminotransferase
C3K59_RS02755	COG5353	protein conserved in bacteria
C3K59_RS02765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3K59_RS02765	COG1199	ATP-dependent helicase activity
C3K59_RS02770	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C3K59_RS02775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3K59_RS02780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C3K59_RS02785	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C3K59_RS02785	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C3K59_RS02795	COG0438	transferase activity, transferring glycosyl groups
C3K59_RS02800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3K59_RS02805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3K59_RS02810	COG1694	Mazg nucleotide pyrophosphohydrolase
C3K59_RS02815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3K59_RS02825	COG4347	Protein of unknown function (DUF1405)
C3K59_RS02830	COG2010	Cytochrome c
C3K59_RS02830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3K59_RS02840	COG0723	plastoquinol--plastocyanin reductase activity
C3K59_RS02850	COG5582	Belongs to the UPF0302 family
C3K59_RS02855	COG0457	Tetratricopeptide repeat
C3K59_RS02860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3K59_RS02865	COG0287	Prephenate dehydrogenase
C3K59_RS02870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3K59_RS02875	COG0159	tryptophan synthase activity
C3K59_RS02880	COG0133	tryptophan synthase activity
C3K59_RS02885	COG0135	phosphoribosylanthranilate isomerase activity
C3K59_RS02900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3K59_RS02905	COG4401	Chorismate mutase type I
C3K59_RS02910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3K59_RS02915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3K59_RS02920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C3K59_RS02925	COG0105	UTP biosynthetic process
C3K59_RS02930	COG0142	geranyltranstransferase activity
C3K59_RS02935	COG2226	methyltransferase
C3K59_RS02940	COG0142	geranyltranstransferase activity
C3K59_RS02950	COG0302	gtp cyclohydrolase
C3K59_RS02955	COG0776	regulation of translation
C3K59_RS02960	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C3K59_RS02975	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C3K59_RS02980	COG1160	GTP binding
C3K59_RS03005	COG1304	FMN binding
C3K59_RS03010	COG0539	negative regulation of cytoplasmic translation
C3K59_RS03015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3K59_RS03025	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C3K59_RS03035	COG3773	Cell wall hydrolase
C3K59_RS03035	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS03045	COG0492	ferredoxin-NADP+ reductase activity
C3K59_RS03050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3K59_RS03055	COG4862	establishment of competence for transformation
C3K59_RS03060	COG1408	metallophosphoesterase
C3K59_RS03070	COG1388	LysM domain
C3K59_RS03075	COG1266	CAAX protease self-immunity
C3K59_RS03090	COG1141	Ferredoxin
C3K59_RS03095	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C3K59_RS03100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3K59_RS03105	COG0710	3-dehydroquinate dehydratase activity
C3K59_RS03115	COG1595	DNA-templated transcription, initiation
C3K59_RS03120	COG5002	protein histidine kinase activity
C3K59_RS03125	COG0745	RESPONSE REGULATOR receiver
C3K59_RS03130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3K59_RS03135	COG1333	cytochrome c biogenesis protein
C3K59_RS03140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS03145	COG1187	pseudouridine synthase activity
C3K59_RS03150	COG0700	Nucleoside recognition
C3K59_RS03155	COG2715	membrane protein required for spore maturation
C3K59_RS03160	COG1686	Belongs to the peptidase S11 family
C3K59_RS03170	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3K59_RS03180	COG1547	Domain of unknown function (DUF309)
C3K59_RS03185	COG0456	acetyltransferase
C3K59_RS03190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3K59_RS03195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3K59_RS03195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3K59_RS03200	COG0307	riboflavin synthase, alpha
C3K59_RS03205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3K59_RS03205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3K59_RS03215	COG0681	Belongs to the peptidase S26 family
C3K59_RS03225	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C3K59_RS03260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3K59_RS03265	COG4086	secreted protein
C3K59_RS03270	COG0019	diaminopimelate decarboxylase activity
C3K59_RS03275	COG0697	spore germination
C3K59_RS03290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3K59_RS03310	COG1191	sigma factor activity
C3K59_RS03315	COG2172	sigma factor antagonist activity
C3K59_RS03320	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K59_RS03325	COG1686	Belongs to the peptidase S11 family
C3K59_RS03330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C3K59_RS03335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C3K59_RS03340	COG4974	Belongs to the 'phage' integrase family
C3K59_RS03350	COG0735	belongs to the Fur family
C3K59_RS03355	COG1300	Membrane
C3K59_RS03375	COG1027	Aspartate ammonia-lyase
C3K59_RS03380	COG0252	asparaginase activity
C3K59_RS03385	COG1396	sequence-specific DNA binding
C3K59_RS03395	COG0494	nUDIX hydrolase
C3K59_RS03405	COG0667	Aldo Keto reductase
C3K59_RS03415	COG1073	alpha beta
C3K59_RS03425	COG4918	Iron-sulphur cluster biosynthesis
C3K59_RS03430	COG0456	acetyltransferase
C3K59_RS03430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C3K59_RS03435	COG2329	Antibiotic biosynthesis monooxygenase
C3K59_RS03440	COG0456	acetyltransferase
C3K59_RS03450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3K59_RS03460	COG2211	Major facilitator Superfamily
C3K59_RS03470	COG0346	lactoylglutathione lyase activity
C3K59_RS03475	COG1072	(Pantothenic acid kinase))
C3K59_RS03480	COG3048	D-serine ammonia-lyase activity
C3K59_RS03485	COG0300	oxidoreductase activity
C3K59_RS03490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3K59_RS03495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3K59_RS03500	COG4187	Peptidase family M20/M25/M40
C3K59_RS03505	COG1902	pentaerythritol trinitrate reductase activity
C3K59_RS03510	COG0596	Alpha beta hydrolase
C3K59_RS03520	COG1234	tRNA 3'-trailer cleavage
C3K59_RS03525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C3K59_RS03530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3K59_RS03535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3K59_RS03545	COG0706	membrane insertase activity
C3K59_RS03550	COG3361	conserved protein (COG2071)
C3K59_RS03555	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3K59_RS03565	COG0346	lactoylglutathione lyase activity
C3K59_RS03575	COG1376	ErfK ybiS ycfS ynhG family protein
C3K59_RS03580	COG4129	membrane
C3K59_RS03585	COG1126	abc transporter atp-binding protein
C3K59_RS03590	COG0765	amino acid transport
C3K59_RS03595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K59_RS03605	COG1597	lipid kinase activity
C3K59_RS03610	COG2814	Major facilitator Superfamily
C3K59_RS03625	COG0022	dehydrogenase e1 component
C3K59_RS03630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3K59_RS03635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3K59_RS03640	COG3426	butyrate kinase activity
C3K59_RS03645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3K59_RS03650	COG0280	phosphate acetyltransferase
C3K59_RS03655	COG3829	transcription factor binding
C3K59_RS03655	COG3290	protein histidine kinase activity
C3K59_RS03665	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C3K59_RS03670	COG2079	MmgE PrpD family protein
C3K59_RS03675	COG0372	Belongs to the citrate synthase family
C3K59_RS03680	COG1960	acyl-CoA dehydrogenase activity
C3K59_RS03685	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3K59_RS03690	COG0183	Belongs to the thiolase family
C3K59_RS03695	COG0584	glycerophosphoryl diester phosphodiesterase
C3K59_RS03700	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS03715	COG1902	pentaerythritol trinitrate reductase activity
C3K59_RS03720	COG0745	RESPONSE REGULATOR receiver
C3K59_RS03725	COG0750	zinc metalloprotease
C3K59_RS03730	COG0497	DNA recombination
C3K59_RS03735	COG1438	arginine binding
C3K59_RS03740	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C3K59_RS03745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3K59_RS03750	COG0142	geranyltranstransferase activity
C3K59_RS03755	COG1722	exodeoxyribonuclease VII activity
C3K59_RS03760	COG1570	exodeoxyribonuclease VII activity
C3K59_RS03765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C3K59_RS03770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3K59_RS03775	COG1302	Protein conserved in bacteria
C3K59_RS03780	COG0439	Biotin carboxylase
C3K59_RS03785	COG0511	ligase activity, forming carbon-carbon bonds
C3K59_RS03825	COG3854	ATPases associated with a variety of cellular activities
C3K59_RS03835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3K59_RS03840	COG0006	proline dipeptidase activity
C3K59_RS03845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3K59_RS03855	COG3872	metal-dependent enzyme
C3K59_RS03865	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3K59_RS03870	COG1321	iron dependent repressor
C3K59_RS03880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3K59_RS03885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3K59_RS03890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3K59_RS03895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3K59_RS03900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3K59_RS03915	COG1396	sequence-specific DNA binding
C3K59_RS03925	COG0681	Belongs to the peptidase S26 family
C3K59_RS03950	COG4940	Competence protein ComGF
C3K59_RS03960	COG4970	Tfp pilus assembly protein FimT
C3K59_RS03965	COG4537	Required for transformation and DNA binding
C3K59_RS03970	COG1459	type II secretion system
C3K59_RS03975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C3K59_RS03980	COG0517	IMP dehydrogenase activity
C3K59_RS03985	COG0598	Magnesium transport protein CorA
C3K59_RS03990	COG1253	flavin adenine dinucleotide binding
C3K59_RS03995	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K59_RS04005	COG1393	Belongs to the ArsC family
C3K59_RS04015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3K59_RS04025	COG0011	TIGRFAM Protein of
C3K59_RS04035	COG2866	Carboxypeptidase
C3K59_RS04040	COG1368	sulfuric ester hydrolase activity
C3K59_RS04045	COG1940	carbohydrate kinase activity
C3K59_RS04050	COG4483	Protein conserved in bacteria
C3K59_RS04055	COG0705	Rhomboid family
C3K59_RS04055	COG0457	Tetratricopeptide repeat
C3K59_RS04065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3K59_RS04075	COG0438	transferase activity, transferring glycosyl groups
C3K59_RS04090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3K59_RS04095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3K59_RS04100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3K59_RS04105	COG0581	inorganic phosphate transmembrane transporter activity
C3K59_RS04110	COG0573	inorganic phosphate transmembrane transporter activity
C3K59_RS04115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C3K59_RS04125	COG0477	Major facilitator Superfamily
C3K59_RS04130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3K59_RS04135	COG2839	Protein conserved in bacteria
C3K59_RS04140	COG5521	maltodextrose utilization protein MalA
C3K59_RS04145	COG1388	LysM domain
C3K59_RS04150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3K59_RS04155	COG4709	membrane
C3K59_RS04160	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C3K59_RS04165	COG0735	belongs to the Fur family
C3K59_RS04170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3K59_RS04180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C3K59_RS04185	COG0513	Belongs to the DEAD box helicase family
C3K59_RS04195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3K59_RS04200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3K59_RS04205	COG2384	SAM-dependent methyltransferase
C3K59_RS04210	COG2010	Cytochrome c
C3K59_RS04215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3K59_RS04220	COG0358	DNA primase activity
C3K59_RS04225	COG1671	Belongs to the UPF0178 family
C3K59_RS04230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C3K59_RS04235	COG0517	IMP dehydrogenase activity
C3K59_RS04240	COG0751	glycine-tRNA ligase activity
C3K59_RS04250	COG1381	Involved in DNA repair and RecF pathway recombination
C3K59_RS04260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C3K59_RS04265	COG0295	cytidine deaminase activity
C3K59_RS04270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C3K59_RS04275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3K59_RS04280	COG1480	7TM receptor with intracellular HD hydrolase
C3K59_RS04285	COG1702	phosphate starvation-inducible protein PhoH
C3K59_RS04305	COG4864	UPF0365 protein
C3K59_RS04315	COG1610	YqeY-like protein
C3K59_RS04325	COG1283	sodium-dependent phosphate transmembrane transporter activity
C3K59_RS04330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3K59_RS04335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C3K59_RS04340	COG2264	protein methyltransferase activity
C3K59_RS04345	COG0484	heat shock protein binding
C3K59_RS04350	COG0443	Heat shock 70 kDa protein
C3K59_RS04355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3K59_RS04360	COG1420	regulation of RNA biosynthetic process
C3K59_RS04365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3K59_RS04370	COG0481	GTPase activity
C3K59_RS04380	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS04385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C3K59_RS04390	COG0268	Binds directly to 16S ribosomal RNA
C3K59_RS04415	COG2131	deaminase
C3K59_RS04420	COG1596	polysaccharide export
C3K59_RS04420	COG1555	photosystem II stabilization
C3K59_RS04425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3K59_RS04430	COG2226	methyltransferase
C3K59_RS04435	COG0799	negative regulation of ribosome biogenesis
C3K59_RS04440	COG1713	HD superfamily hydrolase involved in NAD metabolism
C3K59_RS04445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3K59_RS04450	COG1534	Rna-binding protein
C3K59_RS04455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3K59_RS04460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C3K59_RS04465	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C3K59_RS04475	COG2755	lipolytic protein G-D-S-L family
C3K59_RS04480	COG5632	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS04480	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS04485	COG0398	Pfam SNARE associated Golgi protein
C3K59_RS04490	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C3K59_RS04500	COG3209	COG3209 Rhs family protein
C3K59_RS04510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3K59_RS04520	COG0798	PFAM Bile acid sodium symporter
C3K59_RS04525	COG0346	lactoylglutathione lyase activity
C3K59_RS04530	COG0640	Transcriptional regulator
C3K59_RS04535	COG3403	YqcI/YcgG family
C3K59_RS04555	COG0604	alcohol dehydrogenase
C3K59_RS04580	COG0457	Tetratricopeptide repeat
C3K59_RS04595	COG5444	nuclease activity
C3K59_RS04620	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS04620	COG5632	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS04625	COG4824	toxin secretion phage lysis holin
C3K59_RS04655	COG3778	Protein conserved in bacteria
C3K59_RS04660	COG3299	homolog of phage Mu protein gp47
C3K59_RS04665	COG3628	GPW Gp25 family protein
C3K59_RS04675	COG4193	domain, Protein
C3K59_RS04680	COG1652	LysM domain
C3K59_RS04685	COG5280	Phage tail tape measure protein TP901
C3K59_RS04685	COG3953	SLT domain
C3K59_RS04745	COG4653	Phage capsid family
C3K59_RS04750	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C3K59_RS04760	COG2369	cell adhesion
C3K59_RS04765	COG5518	Phage portal protein
C3K59_RS04770	COG1783	phage Terminase large subunit
C3K59_RS04775	COG5484	DNA packaging
C3K59_RS04810	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C3K59_RS04820	COG1484	DNA-dependent DNA replication
C3K59_RS04825	COG3935	DnaD domain protein
C3K59_RS04830	COG3723	Recombinational DNA repair protein, rece pathway
C3K59_RS04865	COG1476	TRANSCRIPTIONal
C3K59_RS04870	COG3620	sequence-specific DNA binding
C3K59_RS04880	COG0563	adenylate kinase activity
C3K59_RS04885	COG2856	Zn peptidase
C3K59_RS04905	COG4124	Belongs to the glycosyl hydrolase 26 family
C3K59_RS04920	COG0425	Belongs to the sulfur carrier protein TusA family
C3K59_RS04920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3K59_RS04930	COG1937	Protein conserved in bacteria
C3K59_RS04935	COG0662	Cupin 2, conserved barrel domain protein
C3K59_RS04945	COG0789	Transcriptional regulator
C3K59_RS04945	COG4978	Transcriptional regulator
C3K59_RS04950	COG2814	Major facilitator Superfamily
C3K59_RS04955	COG0456	acetyltransferase
C3K59_RS04960	COG1253	flavin adenine dinucleotide binding
C3K59_RS04970	COG0697	spore germination
C3K59_RS04975	COG0583	DNA-binding transcription factor activity
C3K59_RS04985	COG1230	cation diffusion facilitator family transporter
C3K59_RS04990	COG1942	4-Oxalocrotonate Tautomerase
C3K59_RS04995	COG0583	DNA-binding transcription factor activity
C3K59_RS05005	COG1114	Component of the transport system for branched-chain amino acids
C3K59_RS05020	COG1522	sequence-specific DNA binding
C3K59_RS05030	COG2124	cytochrome p450
C3K59_RS05040	COG1335	isochorismatase
C3K59_RS05055	COG2318	DinB family
C3K59_RS05075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3K59_RS05085	COG2186	Transcriptional regulator
C3K59_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS05105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3K59_RS05110	COG3959	Transketolase, thiamine diphosphate binding domain
C3K59_RS05120	COG4978	Transcriptional regulator
C3K59_RS05120	COG0789	Transcriptional regulator
C3K59_RS05125	COG2315	Protein conserved in bacteria
C3K59_RS05140	COG1595	DNA-templated transcription, initiation
C3K59_RS05145	COG0667	Aldo Keto reductase
C3K59_RS05150	COG2851	Citrate transporter
C3K59_RS05155	COG0583	DNA-binding transcription factor activity
C3K59_RS05165	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS05170	COG5566	PFAM Mor transcription activator
C3K59_RS05175	COG0596	Alpha beta hydrolase
C3K59_RS05180	COG4991	sh3 domain protein
C3K59_RS05185	COG4991	sh3 domain protein
C3K59_RS05195	COG0346	lactoylglutathione lyase activity
C3K59_RS05205	COG5577	PFAM Coat F domain
C3K59_RS05210	COG1063	alcohol dehydrogenase
C3K59_RS05220	COG5577	PFAM Coat F domain
C3K59_RS05225	COG0789	Transcriptional regulator
C3K59_RS05235	COG1064	alcohol dehydrogenase
C3K59_RS05240	COG0693	protein deglycase activity
C3K59_RS05245	COG1621	beta-fructofuranosidase activity
C3K59_RS05250	COG3716	PTS system mannose fructose sorbose family IID component
C3K59_RS05255	COG3715	PTS system
C3K59_RS05260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K59_RS05265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K59_RS05270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3K59_RS05270	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C3K59_RS05280	COG1113	amino acid transport
C3K59_RS05285	COG1280	lysine exporter protein (LysE YggA)
C3K59_RS05290	COG1378	Sugar-specific transcriptional regulator TrmB
C3K59_RS05330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3K59_RS05335	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C3K59_RS05340	COG2986	histidine ammonia-lyase
C3K59_RS05345	COG2084	Dehydrogenase
C3K59_RS05365	COG1131	(ABC) transporter
C3K59_RS05370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3K59_RS05385	COG1309	transcriptional regulator
C3K59_RS05390	COG2226	methyltransferase
C3K59_RS05405	COG2116	formate transmembrane transporter activity
C3K59_RS05410	COG5609	conserved protein (DUF2294)
C3K59_RS05415	COG3383	formate dehydrogenase (NAD+) activity
C3K59_RS05420	COG2427	Protein of unknown function (DUF1641)
C3K59_RS05430	COG0626	cystathionine gamma-synthase activity
C3K59_RS05440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C3K59_RS05445	COG2226	methyltransferase
C3K59_RS05460	COG0768	penicillin binding
C3K59_RS05465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3K59_RS05470	COG0572	uridine kinase
C3K59_RS05485	COG4122	O-methyltransferase activity
C3K59_RS05490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3K59_RS05495	COG3906	Belongs to the UPF0473 family
C3K59_RS05500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3K59_RS05505	COG4472	Bacterial protein of unknown function (DUF965)
C3K59_RS05510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3K59_RS05515	COG0628	permease
C3K59_RS05520	COG1126	abc transporter atp-binding protein
C3K59_RS05525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K59_RS05530	COG0765	amino acid transport
C3K59_RS05535	COG0765	amino acid transport
C3K59_RS05550	COG3881	PFAM PRC-barrel domain
C3K59_RS05560	COG0457	Tetratricopeptide repeat
C3K59_RS05565	COG0482	sulfurtransferase activity
C3K59_RS05570	COG1104	cysteine desulfurase activity
C3K59_RS05575	COG1959	2 iron, 2 sulfur cluster binding
C3K59_RS05580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3K59_RS05585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C3K59_RS05595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3K59_RS05600	COG0124	histidyl-tRNA synthetase
C3K59_RS05610	COG3103	Sh3 type 3 domain protein
C3K59_RS05610	COG4991	sh3 domain protein
C3K59_RS05610	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS05615	COG1490	D-aminoacyl-tRNA deacylase activity
C3K59_RS05625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3K59_RS05630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C3K59_RS05630	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C3K59_RS05635	COG5416	Lipopolysaccharide assembly protein A domain
C3K59_RS05640	COG0490	domain, Protein
C3K59_RS05645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3K59_RS05645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3K59_RS05655	COG2244	polysaccharide biosynthetic process
C3K59_RS05660	COG2323	membrane
C3K59_RS05670	COG1862	Preprotein translocase
C3K59_RS05675	COG0343	queuine tRNA-ribosyltransferase activity
C3K59_RS05680	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3K59_RS05690	COG2255	four-way junction helicase activity
C3K59_RS05695	COG0632	four-way junction helicase activity
C3K59_RS05705	COG2814	Major facilitator Superfamily
C3K59_RS05710	COG0673	inositol 2-dehydrogenase activity
C3K59_RS05715	COG2112	serine threonine protein kinase
C3K59_RS05735	COG1115	amino acid carrier protein
C3K59_RS05740	COG0217	transcriptional regulatory protein
C3K59_RS05750	COG1388	LysM domain
C3K59_RS05755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C3K59_RS05760	COG0157	Belongs to the NadC ModD family
C3K59_RS05765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C3K59_RS05770	COG1104	cysteine desulfurase activity
C3K59_RS05775	COG1827	regulation of RNA biosynthetic process
C3K59_RS05780	COG0077	Prephenate dehydratase
C3K59_RS05785	COG4492	Belongs to the UPF0735 family
C3K59_RS05790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3K59_RS05795	COG3290	protein histidine kinase activity
C3K59_RS05805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3K59_RS05815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3K59_RS05820	COG1994	Peptidase M50
C3K59_RS05825	COG0739	heme binding
C3K59_RS05830	COG2894	cell division
C3K59_RS05835	COG0850	regulation of cytokinetic process
C3K59_RS05840	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C3K59_RS05850	COG1077	Cell shape determining protein MreB Mrl
C3K59_RS05890	COG5444	nuclease activity
C3K59_RS05900	COG1388	LysM domain
C3K59_RS05900	COG5632	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS05900	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS05905	COG4824	toxin secretion phage lysis holin
C3K59_RS05930	COG5434	Belongs to the glycosyl hydrolase 28 family
C3K59_RS05935	COG1705	Flagellar rod assembly protein muramidase FlgJ
C3K59_RS05945	COG3953	SLT domain
C3K59_RS05945	COG5280	Phage tail tape measure protein TP901
C3K59_RS06110	COG1396	sequence-specific DNA binding
C3K59_RS06125	COG2003	Belongs to the UPF0758 family
C3K59_RS06130	COG0424	maF-like protein
C3K59_RS06145	COG0285	dihydrofolate synthase activity
C3K59_RS06150	COG0525	valine-tRNA ligase activity
C3K59_RS06160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3K59_RS06165	COG1388	LysM domain
C3K59_RS06170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3K59_RS06175	COG0113	porphobilinogen synthase activity
C3K59_RS06180	COG1587	Uroporphyrinogen-III synthase
C3K59_RS06185	COG0181	hydroxymethylbilane synthase activity
C3K59_RS06190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3K59_RS06195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C3K59_RS06210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3K59_RS06215	COG1067	ATP-dependent peptidase activity
C3K59_RS06215	COG0470	DNA polymerase III
C3K59_RS06220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C3K59_RS06225	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3K59_RS06230	COG0457	Tetratricopeptide repeat
C3K59_RS06230	COG1477	protein flavinylation
C3K59_RS06235	COG0066	3-isopropylmalate dehydratase activity
C3K59_RS06240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3K59_RS06245	COG0473	3-isopropylmalate dehydrogenase activity
C3K59_RS06250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3K59_RS06255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3K59_RS06260	COG0440	acetolactate synthase activity
C3K59_RS06265	COG0028	Belongs to the TPP enzyme family
C3K59_RS06275	COG0454	-acetyltransferase
C3K59_RS06280	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C3K59_RS06290	COG0622	Phosphoesterase
C3K59_RS06295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3K59_RS06300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C3K59_RS06305	COG5401	PFAM Sporulation and spore germination
C3K59_RS06310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C3K59_RS06315	COG1846	Transcriptional regulator
C3K59_RS06320	COG2197	response regulator
C3K59_RS06325	COG0824	Thioesterase
C3K59_RS06330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3K59_RS06340	COG2009	succinate dehydrogenase
C3K59_RS06345	COG1719	4-vinyl reductase, 4VR
C3K59_RS06350	COG0527	aspartate kinase activity
C3K59_RS06355	COG0322	excinuclease ABC activity
C3K59_RS06360	COG3118	belongs to the thioredoxin family
C3K59_RS06370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3K59_RS06375	COG2086	electron transfer activity
C3K59_RS06380	COG1024	Enoyl-CoA hydratase
C3K59_RS06385	COG1309	transcriptional regulator
C3K59_RS06390	COG0318	PFAM AMP-dependent synthetase and ligase
C3K59_RS06395	COG3766	membrane
C3K59_RS06400	COG1193	negative regulation of DNA recombination
C3K59_RS06405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3K59_RS06405	COG1796	DNA polymerase
C3K59_RS06410	COG1286	toxin biosynthetic process
C3K59_RS06415	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C3K59_RS06420	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3K59_RS06425	COG0072	phenylalanine-tRNA ligase activity
C3K59_RS06425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3K59_RS06430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3K59_RS06440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3K59_RS06450	COG3835	regulator
C3K59_RS06455	COG0277	FAD linked oxidase domain protein
C3K59_RS06460	COG0247	lactate metabolic process
C3K59_RS06465	COG0346	lactoylglutathione lyase activity
C3K59_RS06470	COG1966	Carbon starvation protein
C3K59_RS06475	COG3534	alpha-L-arabinofuranosidase
C3K59_RS06480	COG0395	ABC-type sugar transport system, permease component
C3K59_RS06485	COG1175	transmembrane transport
C3K59_RS06490	COG1653	transport
C3K59_RS06495	COG0371	Dehydrogenase
C3K59_RS06505	COG0235	Class ii aldolase
C3K59_RS06510	COG1069	ribulokinase activity
C3K59_RS06515	COG2160	L-arabinose isomerase activity
C3K59_RS06520	COG3507	Belongs to the glycosyl hydrolase 43 family
C3K59_RS06525	COG1363	Peptidase, m42
C3K59_RS06535	COG3326	Membrane
C3K59_RS06540	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3K59_RS06545	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C3K59_RS06550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3K59_RS06560	COG1346	cytolysis
C3K59_RS06565	COG1380	Effector of murein hydrolase LrgA
C3K59_RS06570	COG3279	Response regulator of the LytR AlgR family
C3K59_RS06575	COG3275	phosphorelay sensor kinase activity
C3K59_RS06580	COG1011	Hydrolase
C3K59_RS06585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3K59_RS06595	COG0398	Pfam SNARE associated Golgi protein
C3K59_RS06600	COG1484	DNA-dependent DNA replication
C3K59_RS06605	COG3611	Membrane attachment protein
C3K59_RS06610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3K59_RS06615	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C3K59_RS06620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3K59_RS06625	COG1733	regulation of RNA biosynthetic process
C3K59_RS06630	COG2814	Major facilitator Superfamily
C3K59_RS06635	COG0656	L-ascorbic acid biosynthetic process
C3K59_RS06640	COG0237	dephospho-CoA kinase activity
C3K59_RS06645	COG1971	Probably functions as a manganese efflux pump
C3K59_RS06650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3K59_RS06655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3K59_RS06655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3K59_RS06660	COG5002	protein histidine kinase activity
C3K59_RS06665	COG0745	RESPONSE REGULATOR receiver
C3K59_RS06670	COG0039	L-malate dehydrogenase activity
C3K59_RS06675	COG0538	isocitrate dehydrogenase activity
C3K59_RS06680	COG0372	Belongs to the citrate synthase family
C3K59_RS06685	COG2707	UPF0756 membrane protein
C3K59_RS06695	COG3030	protein affecting phage T7 exclusion by the F plasmid
C3K59_RS06700	COG0469	pyruvate kinase activity
C3K59_RS06705	COG0205	6-phosphofructokinase activity
C3K59_RS06710	COG0825	malonyl-CoA metabolic process
C3K59_RS06715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C3K59_RS06720	COG0281	malic enzyme
C3K59_RS06725	COG0587	DNA-directed DNA polymerase activity
C3K59_RS06745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C3K59_RS06755	COG4109	DRTGG domain
C3K59_RS06760	COG0730	response to heat
C3K59_RS06765	COG1473	amidohydrolase
C3K59_RS06770	COG0196	riboflavin kinase activity
C3K59_RS06775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K59_RS06780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C3K59_RS06785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K59_RS06790	COG1126	abc transporter atp-binding protein
C3K59_RS06795	COG0765	amino acid transport
C3K59_RS06800	COG0765	amino acid transport
C3K59_RS06805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K59_RS06815	COG0454	-acetyltransferase
C3K59_RS06820	COG0583	DNA-binding transcription factor activity
C3K59_RS06825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C3K59_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS06840	COG0165	Argininosuccinate lyase
C3K59_RS06845	COG0137	argininosuccinate synthase activity
C3K59_RS06850	COG0521	Mo-molybdopterin cofactor biosynthetic process
C3K59_RS06855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3K59_RS06865	COG0827	DNA restriction-modification system
C3K59_RS06870	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C3K59_RS06875	COG3874	Sporulation protein YtfJ
C3K59_RS06885	COG1714	RDD family
C3K59_RS06890	COG0616	signal peptide processing
C3K59_RS06895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3K59_RS06900	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C3K59_RS06905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3K59_RS06915	COG0301	tRNA thio-modification
C3K59_RS06920	COG1104	cysteine desulfurase activity
C3K59_RS06925	COG1114	Component of the transport system for branched-chain amino acids
C3K59_RS06930	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C3K59_RS06935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3K59_RS06940	COG1309	transcriptional regulator
C3K59_RS06945	COG1956	GAF domain-containing protein
C3K59_RS06950	COG2199	diguanylate cyclase activity
C3K59_RS06950	COG2203	Gaf domain
C3K59_RS06960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3K59_RS06965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3K59_RS06970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3K59_RS06975	COG0454	-acetyltransferase
C3K59_RS06980	COG0517	IMP dehydrogenase activity
C3K59_RS06990	COG1360	Flagellar Motor Protein
C3K59_RS06995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C3K59_RS07000	COG1609	Transcriptional regulator
C3K59_RS07005	COG1605	Chorismate mutase
C3K59_RS07005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C3K59_RS07010	COG3118	belongs to the thioredoxin family
C3K59_RS07015	COG4980	gas vesicle protein
C3K59_RS07020	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C3K59_RS07025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3K59_RS07030	COG1674	ftsk spoiiie
C3K59_RS07035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3K59_RS07040	COG4848	Belongs to the UPF0354 family
C3K59_RS07045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS07060	COG1363	Peptidase, m42
C3K59_RS07065	COG5584	Small secreted protein
C3K59_RS07070	COG0281	malic enzyme
C3K59_RS07075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3K59_RS07080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3K59_RS07090	COG0510	thiamine kinase activity
C3K59_RS07095	COG1523	belongs to the glycosyl hydrolase 13 family
C3K59_RS07100	COG1597	lipid kinase activity
C3K59_RS07110	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C3K59_RS07115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3K59_RS07130	COG4473	ABC transporter
C3K59_RS07135	COG1131	(ABC) transporter
C3K59_RS07140	COG1349	DNA-binding transcription factor activity
C3K59_RS07145	COG1187	pseudouridine synthase activity
C3K59_RS07150	COG2244	polysaccharide biosynthetic process
C3K59_RS07155	COG2081	HI0933 family
C3K59_RS07170	COG5578	integral membrane protein
C3K59_RS07180	COG1653	transport
C3K59_RS07190	COG4209	transmembrane transport
C3K59_RS07195	COG2207	Transcriptional regulator
C3K59_RS07200	COG1653	transport
C3K59_RS07205	COG0395	ABC-type sugar transport system, permease component
C3K59_RS07210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3K59_RS07215	COG2124	cytochrome p450
C3K59_RS07220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3K59_RS07230	COG0156	8-amino-7-oxononanoate synthase activity
C3K59_RS07235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3K59_RS07245	COG1073	alpha beta
C3K59_RS07255	COG1653	transport
C3K59_RS07260	COG1175	transmembrane transport
C3K59_RS07265	COG0395	ABC-type sugar transport system, permease component
C3K59_RS07270	COG1486	melibiose metabolic process
C3K59_RS07275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3K59_RS07280	COG0495	leucyl-tRNA aminoacylation
C3K59_RS07290	COG2202	Pas domain
C3K59_RS07290	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K59_RS07295	COG2814	Major facilitator Superfamily
C3K59_RS07300	COG2433	Pfam Transposase IS66
C3K59_RS07305	COG0577	efflux transmembrane transporter activity
C3K59_RS07310	COG1136	(ABC) transporter
C3K59_RS07315	COG2205	protein histidine kinase activity
C3K59_RS07320	COG0745	RESPONSE REGULATOR receiver
C3K59_RS07325	COG0577	efflux transmembrane transporter activity
C3K59_RS07330	COG1136	(ABC) transporter
C3K59_RS07345	COG1131	(ABC) transporter
C3K59_RS07350	COG1725	Transcriptional regulator
C3K59_RS07365	COG1242	4 iron, 4 sulfur cluster binding
C3K59_RS07370	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C3K59_RS07380	COG2267	carboxylic ester hydrolase activity
C3K59_RS07385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C3K59_RS07390	COG1113	amino acid transport
C3K59_RS07395	COG0367	asparagine synthase
C3K59_RS07400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3K59_RS07405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C3K59_RS07415	COG1506	peptidase
C3K59_RS07420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3K59_RS07425	COG1116	anion transmembrane transporter activity
C3K59_RS07430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3K59_RS07435	COG0494	nUDIX hydrolase
C3K59_RS07440	COG4824	toxin secretion phage lysis holin
C3K59_RS07445	COG0783	Belongs to the Dps family
C3K59_RS07460	COG1854	S-ribosylhomocysteine lyase activity
C3K59_RS07465	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3K59_RS07470	COG0288	reversible hydration of carbon dioxide
C3K59_RS07475	COG0254	rRNA binding
C3K59_RS07480	COG1271	oxidase subunit
C3K59_RS07485	COG1294	oxidase, subunit
C3K59_RS07495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3K59_RS07505	COG1121	(ABC) transporter
C3K59_RS07510	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3K59_RS07515	COG4948	Mandelate Racemase Muconate Lactonizing
C3K59_RS07520	COG0318	PFAM AMP-dependent synthetase and ligase
C3K59_RS07525	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C3K59_RS07530	COG0596	Alpha beta hydrolase
C3K59_RS07535	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C3K59_RS07545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3K59_RS07555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C3K59_RS07565	COG0438	transferase activity, transferring glycosyl groups
C3K59_RS07575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3K59_RS07580	COG0438	transferase activity, transferring glycosyl groups
C3K59_RS07585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3K59_RS07590	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C3K59_RS07595	COG0058	SHG alpha-glucan phosphorylase activity
C3K59_RS07600	COG0297	glycogen (starch) synthase activity
C3K59_RS07605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3K59_RS07610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3K59_RS07740	COG3859	Proton-coupled thiamine transporter YuaJ
C3K59_RS07745	COG1247	-acetyltransferase
C3K59_RS07750	COG2268	Band 7 protein
C3K59_RS07755	COG1585	Membrane protein implicated in regulation of membrane protease activity
C3K59_RS07760	COG2318	DinB family
C3K59_RS07770	COG1454	alcohol dehydrogenase
C3K59_RS07775	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS07780	COG1510	regulation of RNA biosynthetic process
C3K59_RS07795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3K59_RS07800	COG4682	membrane
C3K59_RS07805	COG1705	Flagellar rod assembly protein muramidase FlgJ
C3K59_RS07815	COG5553	Cysteine dioxygenase type I
C3K59_RS07825	COG1968	undecaprenyl-diphosphatase activity
C3K59_RS07830	COG0628	permease
C3K59_RS07835	COG0673	inositol 2-dehydrogenase activity
C3K59_RS07840	COG4806	L-rhamnose isomerase
C3K59_RS07845	COG3254	rhamnose metabolic process
C3K59_RS07850	COG1070	Carbohydrate kinase
C3K59_RS07855	COG1349	DNA-binding transcription factor activity
C3K59_RS07870	COG0840	transmembrane signaling receptor activity
C3K59_RS07875	COG0840	transmembrane signaling receptor activity
C3K59_RS07880	COG0840	transmembrane signaling receptor activity
C3K59_RS07895	COG0432	Pfam Uncharacterised protein family UPF0047
C3K59_RS07905	COG0366	Alpha amylase catalytic
C3K59_RS07910	COG1253	flavin adenine dinucleotide binding
C3K59_RS07915	COG2738	Putative neutral zinc metallopeptidase
C3K59_RS07930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3K59_RS07945	COG0166	Belongs to the GPI family
C3K59_RS07950	COG1979	alcohol dehydrogenase
C3K59_RS07955	COG1979	alcohol dehydrogenase
C3K59_RS07960	COG2155	Conserved Protein
C3K59_RS07965	COG1098	S1 RNA binding domain
C3K59_RS07970	COG0436	Aminotransferase
C3K59_RS07975	COG1522	sequence-specific DNA binding
C3K59_RS07980	COG2267	carboxylic ester hydrolase activity
C3K59_RS07990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3K59_RS07995	COG2205	protein histidine kinase activity
C3K59_RS08005	COG5018	Exonuclease
C3K59_RS08015	COG2814	Major facilitator Superfamily
C3K59_RS08020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3K59_RS08025	COG3011	Protein conserved in bacteria
C3K59_RS08035	COG3290	protein histidine kinase activity
C3K59_RS08040	COG4565	transcriptional regulatory protein
C3K59_RS08065	COG3493	citrate carrier protein
C3K59_RS08075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C3K59_RS08075	COG2111	Na H antiporter
C3K59_RS08080	COG2111	Na H antiporter
C3K59_RS08085	COG1006	Multisubunit Na H antiporter MnhC subunit
C3K59_RS08090	COG0651	ATP synthesis coupled electron transport
C3K59_RS08095	COG1863	multisubunit Na H antiporter MnhE subunit
C3K59_RS08100	COG2212	antiporter activity
C3K59_RS08105	COG1320	monovalent cation:proton antiporter activity
C3K59_RS08110	COG2050	protein possibly involved in aromatic compounds catabolism
C3K59_RS08115	COG2197	response regulator
C3K59_RS08120	COG4585	Histidine kinase
C3K59_RS08130	COG0142	geranyltranstransferase activity
C3K59_RS08150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C3K59_RS08155	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C3K59_RS08160	COG1335	isochorismatase
C3K59_RS08165	COG5506	Protein of unknown function (DUF1694)
C3K59_RS08180	COG0628	permease
C3K59_RS08195	COG1418	mRNA catabolic process
C3K59_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS08210	COG1511	domain protein
C3K59_RS08215	COG0433	COG0433 Predicted ATPase
C3K59_RS08215	COG1674	ftsk spoiiie
C3K59_RS08220	COG4499	WXG100 protein secretion system (Wss), protein YukC
C3K59_RS08225	COG5417	Belongs to the EsaB family
C3K59_RS08230	COG4842	Belongs to the WXG100 family
C3K59_RS08235	COG2508	Transcriptional regulator
C3K59_RS08235	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C3K59_RS08240	COG0686	Belongs to the AlaDH PNT family
C3K59_RS08245	COG5634	Uncharacterized conserved protein (DUF2278)
C3K59_RS08250	COG3251	PFAM MbtH domain protein
C3K59_RS08255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS08260	COG1535	isochorismatase
C3K59_RS08260	COG3433	isochorismatase activity
C3K59_RS08265	COG1021	2,3-dihydroxybenzoate-AMP ligase
C3K59_RS08270	COG1169	isochorismate synthase
C3K59_RS08275	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS08280	COG2819	hydrolase of the alpha beta superfamily
C3K59_RS08285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3K59_RS08290	COG1268	BioY protein
C3K59_RS08295	COG2056	Na+-H+ antiporter family
C3K59_RS08300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3K59_RS08305	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C3K59_RS08310	COG3584	3D domain protein
C3K59_RS08325	COG1252	NADH dehydrogenase
C3K59_RS08330	COG0492	ferredoxin-NADP+ reductase activity
C3K59_RS08340	COG0516	GMP reductase activity
C3K59_RS08345	COG2808	Putative FMN-binding domain
C3K59_RS08350	COG0456	acetyltransferase
C3K59_RS08355	COG0316	Belongs to the HesB IscA family
C3K59_RS08360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C3K59_RS08365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C3K59_RS08370	COG4844	belongs to the
C3K59_RS08375	COG1252	NADH dehydrogenase
C3K59_RS08380	COG4837	Protein of unknown function (DUF1462)
C3K59_RS08385	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C3K59_RS08395	COG0083	homoserine kinase activity
C3K59_RS08400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3K59_RS08405	COG0460	homoserine dehydrogenase
C3K59_RS08410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3K59_RS08415	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C3K59_RS08420	COG0647	UMP catabolic process
C3K59_RS08425	COG2445	Protein of unknown function DUF86
C3K59_RS08430	COG4470	Protein conserved in bacteria
C3K59_RS08440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3K59_RS08445	COG0739	heme binding
C3K59_RS08455	COG3377	Domain of unknown function (DUF1805)
C3K59_RS08460	COG0737	Belongs to the 5'-nucleotidase family
C3K59_RS08465	COG0730	response to heat
C3K59_RS08470	COG1801	Protein of unknown function DUF72
C3K59_RS08480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3K59_RS08485	COG2508	Transcriptional regulator
C3K59_RS08490	COG2233	PERMEase
C3K59_RS08495	COG2233	PERMEase
C3K59_RS08500	COG3648	Uricase
C3K59_RS08500	COG3195	allantoin biosynthetic process
C3K59_RS08505	COG2351	hydroxyisourate hydrolase activity
C3K59_RS08515	COG2080	2 iron, 2 sulfur cluster binding
C3K59_RS08520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C3K59_RS08525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C3K59_RS08530	COG2068	MobA-Related Protein
C3K59_RS08535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C3K59_RS08540	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3K59_RS08545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3K59_RS08555	COG2356	endonuclease I
C3K59_RS08560	COG3842	ATPase activity
C3K59_RS08565	COG2188	Transcriptional regulator
C3K59_RS08570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3K59_RS08575	COG0395	ABC-type sugar transport system, permease component
C3K59_RS08580	COG1175	transmembrane transport
C3K59_RS08585	COG1653	transport
C3K59_RS08590	COG2222	sugar isomerase
C3K59_RS08595	COG0322	excinuclease ABC activity
C3K59_RS08600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3K59_RS08630	COG0457	Tetratricopeptide repeat
C3K59_RS08635	COG5444	nuclease activity
C3K59_RS08645	COG1388	LysM domain
C3K59_RS08645	COG5632	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS08645	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS08650	COG4824	toxin secretion phage lysis holin
C3K59_RS08675	COG5434	Belongs to the glycosyl hydrolase 28 family
C3K59_RS08690	COG5412	phage tail tape measure protein
C3K59_RS08690	COG3953	SLT domain
C3K59_RS08785	COG0305	Participates in initiation and elongation during chromosome replication
C3K59_RS08810	COG3645	SOS response
C3K59_RS08810	COG3646	Phage regulatory protein
C3K59_RS08845	COG1396	sequence-specific DNA binding
C3K59_RS08860	COG0719	Fe-S assembly protein
C3K59_RS08865	COG0822	iron-sulfur transferase activity
C3K59_RS08870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3K59_RS08875	COG0719	Fe-S assembly protein
C3K59_RS08880	COG0396	ATPase activity
C3K59_RS08890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3K59_RS08895	COG1464	Belongs to the NlpA lipoprotein family
C3K59_RS08900	COG2011	ABC-type metal ion transport system permease component
C3K59_RS08905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3K59_RS08915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS08920	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C3K59_RS08930	COG0509	glycine decarboxylation via glycine cleavage system
C3K59_RS08935	COG1393	Belongs to the ArsC family
C3K59_RS08940	COG1960	acyl-CoA dehydrogenase activity
C3K59_RS08945	COG0183	Belongs to the thiolase family
C3K59_RS08960	COG0506	proline dehydrogenase activity
C3K59_RS08970	COG5577	PFAM Coat F domain
C3K59_RS08980	COG0477	Major facilitator Superfamily
C3K59_RS08985	COG1942	4-Oxalocrotonate Tautomerase
C3K59_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS08995	COG0583	DNA-binding transcription factor activity
C3K59_RS09005	COG1120	ATPase activity
C3K59_RS09020	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS09025	COG0783	Belongs to the Dps family
C3K59_RS09030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3K59_RS09035	COG0745	RESPONSE REGULATOR receiver
C3K59_RS09040	COG2770	Histidine kinase
C3K59_RS09040	COG2205	protein histidine kinase activity
C3K59_RS09050	COG1309	transcriptional regulator
C3K59_RS09055	COG0114	fumarate hydratase activity
C3K59_RS09070	COG0814	amino acid
C3K59_RS09080	COG2197	response regulator
C3K59_RS09085	COG4585	Histidine kinase
C3K59_RS09090	COG4758	membrane
C3K59_RS09095	COG3595	metallopeptidase activity
C3K59_RS09100	COG1842	Phage shock protein A
C3K59_RS09105	COG4758	membrane
C3K59_RS09110	COG2814	Major facilitator Superfamily
C3K59_RS09115	COG2096	Adenosyltransferase
C3K59_RS09120	COG1120	ATPase activity
C3K59_RS09125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS09130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3K59_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS09140	COG3386	PFAM SMP-30 Gluconolaconase
C3K59_RS09145	COG2205	protein histidine kinase activity
C3K59_RS09150	COG0745	RESPONSE REGULATOR receiver
C3K59_RS09160	COG1191	sigma factor activity
C3K59_RS09170	COG2140	Oxalate decarboxylase
C3K59_RS09180	COG0577	efflux transmembrane transporter activity
C3K59_RS09185	COG1136	(ABC) transporter
C3K59_RS09190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3K59_RS09195	COG1120	ATPase activity
C3K59_RS09200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS09205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS09210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3K59_RS09215	COG0531	amino acid
C3K59_RS09225	COG1988	membrane-bound metal-dependent
C3K59_RS09235	COG1910	domain protein
C3K59_RS09240	COG0725	ABC transporter, periplasmic molybdate-binding protein
C3K59_RS09245	COG4149	molybdate abc transporter
C3K59_RS09250	COG0656	L-ascorbic acid biosynthetic process
C3K59_RS09260	COG0025	NhaP-type Na H and K H
C3K59_RS09265	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3K59_RS09275	COG3973	AAA domain
C3K59_RS09280	COG2860	membrane
C3K59_RS09285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C3K59_RS09290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C3K59_RS09295	COG2217	Heavy metal translocating P-type atpase
C3K59_RS09300	COG2217	Heavy metal translocating P-type atpase
C3K59_RS09305	COG2608	mercury ion transmembrane transporter activity
C3K59_RS09310	COG1937	Protein conserved in bacteria
C3K59_RS09320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3K59_RS09325	COG1289	transmembrane transporter activity
C3K59_RS09335	COG2076	Multidrug Resistance protein
C3K59_RS09340	COG1309	transcriptional regulator
C3K59_RS09345	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS09355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C3K59_RS09360	COG0557	exoribonuclease II activity
C3K59_RS09370	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3K59_RS09375	COG0596	Alpha beta hydrolase
C3K59_RS09380	COG1476	TRANSCRIPTIONal
C3K59_RS09385	COG1396	sequence-specific DNA binding
C3K59_RS09390	COG1396	sequence-specific DNA binding
C3K59_RS09395	COG1733	regulation of RNA biosynthetic process
C3K59_RS09400	COG0840	transmembrane signaling receptor activity
C3K59_RS09405	COG1174	glycine betaine transport
C3K59_RS09410	COG1732	Glycine betaine
C3K59_RS09415	COG1174	glycine betaine transport
C3K59_RS09425	COG1510	regulation of RNA biosynthetic process
C3K59_RS09430	COG1174	glycine betaine transport
C3K59_RS09435	COG1732	Glycine betaine
C3K59_RS09440	COG1174	glycine betaine transport
C3K59_RS09445	COG0517	IMP dehydrogenase activity
C3K59_RS09445	COG1125	glycine betaine transport
C3K59_RS09450	COG1510	regulation of RNA biosynthetic process
C3K59_RS09455	COG2095	MarC family integral membrane protein
C3K59_RS09465	COG3064	Membrane
C3K59_RS09470	COG4640	response to antibiotic
C3K59_RS09475	COG0456	acetyltransferase
C3K59_RS09490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3K59_RS09510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3K59_RS09515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3K59_RS09525	COG2234	aminopeptidase activity
C3K59_RS09530	COG0148	phosphopyruvate hydratase activity
C3K59_RS09535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C3K59_RS09540	COG0149	triose-phosphate isomerase activity
C3K59_RS09545	COG0126	phosphoglycerate kinase activity
C3K59_RS09550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3K59_RS09555	COG2390	Transcriptional regulator
C3K59_RS09565	COG1609	Transcriptional regulator
C3K59_RS09570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K59_RS09575	COG0583	DNA-binding transcription factor activity
C3K59_RS09580	COG0697	spore germination
C3K59_RS09585	COG1113	amino acid transport
C3K59_RS09590	COG3858	chitin binding
C3K59_RS09595	COG1556	Lactate utilization protein
C3K59_RS09600	COG1139	Iron-sulfur cluster binding protein
C3K59_RS09610	COG2197	response regulator
C3K59_RS09615	COG4585	Histidine kinase
C3K59_RS09625	COG1131	(ABC) transporter
C3K59_RS09630	COG0596	Alpha beta hydrolase
C3K59_RS09635	COG2208	phosphoserine phosphatase activity
C3K59_RS09640	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C3K59_RS09645	COG1874	Beta-galactosidase
C3K59_RS09650	COG3833	ABC-type maltose transport systems, permease component
C3K59_RS09655	COG1175	transmembrane transport
C3K59_RS09660	COG2182	Extracellular solute-binding protein
C3K59_RS09665	COG1609	Transcriptional regulator
C3K59_RS09675	COG1620	l-lactate permease
C3K59_RS09680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C3K59_RS09690	COG5039	Polysaccharide pyruvyl transferase
C3K59_RS09695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3K59_RS09700	COG0110	maltose O-acetyltransferase activity
C3K59_RS09705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3K59_RS09710	COG2244	polysaccharide biosynthetic process
C3K59_RS09715	COG1216	Glycosyl transferase, family 2
C3K59_RS09720	COG5039	Polysaccharide pyruvyl transferase
C3K59_RS09725	COG1216	Glycosyl transferase, family 2
C3K59_RS09735	COG0438	transferase activity, transferring glycosyl groups
C3K59_RS09740	COG1215	transferase activity, transferring glycosyl groups
C3K59_RS09745	COG0438	transferase activity, transferring glycosyl groups
C3K59_RS09750	COG1086	Polysaccharide biosynthesis protein
C3K59_RS09755	COG0489	protein tyrosine kinase activity
C3K59_RS09760	COG3944	biosynthesis protein
C3K59_RS09765	COG1396	sequence-specific DNA binding
C3K59_RS09770	COG2272	Belongs to the type-B carboxylesterase lipase family
C3K59_RS09780	COG3479	Phenolic acid decarboxylase
C3K59_RS09795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C3K59_RS09800	COG1621	beta-fructofuranosidase activity
C3K59_RS09805	COG1621	beta-fructofuranosidase activity
C3K59_RS09810	COG0531	amino acid
C3K59_RS09815	COG1309	transcriptional regulator
C3K59_RS09820	COG2076	Multidrug Resistance protein
C3K59_RS09825	COG2076	Multidrug Resistance protein
C3K59_RS09835	COG0277	FAD linked oxidase domain protein
C3K59_RS09840	COG3621	Patatin-like phospholipase
C3K59_RS09850	COG0740	serine-type endopeptidase activity
C3K59_RS09855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3K59_RS09860	COG0366	Alpha amylase catalytic
C3K59_RS09865	COG1554	hydrolase, family 65, central catalytic
C3K59_RS09870	COG5521	maltodextrose utilization protein MalA
C3K59_RS09875	COG3833	ABC-type maltose transport systems, permease component
C3K59_RS09880	COG1175	transmembrane transport
C3K59_RS09885	COG2182	Extracellular solute-binding protein
C3K59_RS09890	COG0366	Alpha amylase catalytic
C3K59_RS09895	COG1609	Transcriptional regulator
C3K59_RS09900	COG1611	Belongs to the LOG family
C3K59_RS09905	COG1694	Mazg nucleotide pyrophosphohydrolase
C3K59_RS09910	COG0659	secondary active sulfate transmembrane transporter activity
C3K59_RS09915	COG0288	reversible hydration of carbon dioxide
C3K59_RS09920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3K59_RS09925	COG0577	efflux transmembrane transporter activity
C3K59_RS09930	COG1136	(ABC) transporter
C3K59_RS09935	COG5002	protein histidine kinase activity
C3K59_RS09940	COG0745	RESPONSE REGULATOR receiver
C3K59_RS09950	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C3K59_RS09955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K59_RS09960	COG1481	regulation of sporulation
C3K59_RS09965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C3K59_RS09970	COG1660	Displays ATPase and GTPase activities
C3K59_RS09975	COG1051	belongs to the nudix hydrolase family
C3K59_RS09980	COG0492	ferredoxin-NADP+ reductase activity
C3K59_RS09985	COG0791	NLP P60 protein
C3K59_RS09985	COG3883	PFAM NLP P60 protein
C3K59_RS09990	COG0457	Tetratricopeptide repeat
C3K59_RS09995	COG1132	(ABC) transporter
C3K59_RS10015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3K59_RS10015	COG0140	phosphoribosyl-ATP diphosphatase activity
C3K59_RS10020	COG0107	imidazoleglycerol-phosphate synthase activity
C3K59_RS10025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C3K59_RS10030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3K59_RS10035	COG0131	Imidazoleglycerol-phosphate dehydratase
C3K59_RS10045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3K59_RS10050	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C3K59_RS10055	COG4990	cell redox homeostasis
C3K59_RS10060	COG5297	Belongs to the glycosyl hydrolase family 6
C3K59_RS10065	COG0110	maltose O-acetyltransferase activity
C3K59_RS10070	COG0546	phosphoglycolate phosphatase activity
C3K59_RS10075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C3K59_RS10080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C3K59_RS10085	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C3K59_RS10090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C3K59_RS10095	COG0363	glucosamine-6-phosphate deaminase activity
C3K59_RS10100	COG2188	Transcriptional regulator
C3K59_RS10105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C3K59_RS10110	COG1950	PFAM Membrane protein of
C3K59_RS10115	COG1983	PspC domain protein
C3K59_RS10120	COG3595	metallopeptidase activity
C3K59_RS10140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3K59_RS10145	COG0556	nucleotide-excision repair
C3K59_RS10150	COG4897	Protein conserved in bacteria
C3K59_RS10155	COG3848	Pyruvate phosphate dikinase
C3K59_RS10155	COG0574	Belongs to the PEP-utilizing enzyme family
C3K59_RS10160	COG1309	transcriptional regulator
C3K59_RS10165	COG2814	Major facilitator Superfamily
C3K59_RS10170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3K59_RS10180	COG0793	Belongs to the peptidase S41A family
C3K59_RS10180	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS10185	COG2177	Part of the ABC transporter FtsEX involved in
C3K59_RS10190	COG2884	Cell division ATP-binding protein ftsE
C3K59_RS10195	COG2010	Cytochrome c
C3K59_RS10200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3K59_RS10210	COG0653	protein targeting
C3K59_RS10215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C3K59_RS10230	COG1516	flagellar protein fliS
C3K59_RS10235	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C3K59_RS10240	COG1334	flagellar protein FlaG
C3K59_RS10245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C3K59_RS10250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C3K59_RS10255	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C3K59_RS10265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C3K59_RS10270	COG4786	Flagellar basal body rod
C3K59_RS10270	COG1256	bacterial-type flagellum assembly
C3K59_RS10275	COG3418	PFAM FlgN family protein
C3K59_RS10280	COG2747	anti-sigma28 factor FlgM
C3K59_RS10290	COG1040	competence protein
C3K59_RS10300	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C3K59_RS10305	COG1307	EDD domain protein, DegV family
C3K59_RS10310	COG2197	response regulator
C3K59_RS10315	COG4585	Histidine kinase
C3K59_RS10320	COG1739	Uncharacterized protein family UPF0029
C3K59_RS10325	COG1316	TRANSCRIPTIONal
C3K59_RS10330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3K59_RS10335	COG0438	transferase activity, transferring glycosyl groups
C3K59_RS10340	COG1215	transferase activity, transferring glycosyl groups
C3K59_RS10345	COG3206	protein involved in exopolysaccharide biosynthesis
C3K59_RS10350	COG3307	-O-antigen
C3K59_RS10360	COG0297	glycogen (starch) synthase activity
C3K59_RS10360	COG0438	transferase activity, transferring glycosyl groups
C3K59_RS10365	COG2244	polysaccharide biosynthetic process
C3K59_RS10375	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS10375	COG2247	cell wall binding repeat
C3K59_RS10390	COG1316	TRANSCRIPTIONal
C3K59_RS10395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C3K59_RS10400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3K59_RS10405	COG1134	teichoic acid transport
C3K59_RS10410	COG1682	transport, permease protein
C3K59_RS10415	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3K59_RS10420	COG0438	transferase activity, transferring glycosyl groups
C3K59_RS10425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3K59_RS10430	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C3K59_RS10435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3K59_RS10445	COG4193	domain, Protein
C3K59_RS10450	COG1482	cell wall glycoprotein biosynthetic process
C3K59_RS10455	COG0697	spore germination
C3K59_RS10460	COG0814	amino acid
C3K59_RS10470	COG2814	Major facilitator Superfamily
C3K59_RS10475	COG1316	TRANSCRIPTIONal
C3K59_RS10480	COG0561	phosphatase activity
C3K59_RS10485	COG0791	NLP P60 protein
C3K59_RS10495	COG2843	Capsule synthesis protein
C3K59_RS10505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3K59_RS10510	COG1609	Transcriptional regulator
C3K59_RS10515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3K59_RS10520	COG1869	D-ribose catabolic process
C3K59_RS10525	COG1129	ABC transporter
C3K59_RS10530	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3K59_RS10535	COG1879	ABC-type sugar transport system periplasmic component
C3K59_RS10540	COG3103	Sh3 type 3 domain protein
C3K59_RS10550	COG2249	NAD(P)H dehydrogenase (quinone) activity
C3K59_RS10555	COG3527	Alpha-acetolactate decarboxylase
C3K59_RS10560	COG0028	Belongs to the TPP enzyme family
C3K59_RS10565	COG0583	DNA-binding transcription factor activity
C3K59_RS10585	COG5337	Spore coat protein CotH
C3K59_RS10595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3K59_RS10605	COG0405	Gamma-glutamyltransferase
C3K59_RS10610	COG1522	sequence-specific DNA binding
C3K59_RS10615	COG2059	Chromate
C3K59_RS10620	COG2059	Chromate
C3K59_RS10630	COG0655	NAD(P)H dehydrogenase (quinone) activity
C3K59_RS10635	COG0583	DNA-binding transcription factor activity
C3K59_RS10650	COG5444	nuclease activity
C3K59_RS10670	COG3878	Protein conserved in bacteria
C3K59_RS10675	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C3K59_RS10680	COG4464	protein tyrosine phosphatase activity
C3K59_RS10685	COG0489	protein tyrosine kinase activity
C3K59_RS10690	COG3944	biosynthesis protein
C3K59_RS10700	COG4715	Zinc finger, swim domain protein
C3K59_RS10705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3K59_RS10710	COG0561	phosphatase activity
C3K59_RS10715	COG1349	DNA-binding transcription factor activity
C3K59_RS10720	COG0629	single-stranded DNA binding
C3K59_RS10735	COG3764	Sortase (surface protein transpeptidase)
C3K59_RS10740	COG0745	RESPONSE REGULATOR receiver
C3K59_RS10740	COG2972	Histidine kinase
C3K59_RS10745	COG1970	mechanosensitive ion channel activity
C3K59_RS10750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3K59_RS10755	COG0457	Tetratricopeptide repeat
C3K59_RS10760	COG4786	Flagellar basal body rod
C3K59_RS10765	COG4786	Flagellar basal body rod
C3K59_RS10770	COG1077	Cell shape determining protein MreB Mrl
C3K59_RS10775	COG1609	Transcriptional regulator
C3K59_RS10785	COG1846	Transcriptional regulator
C3K59_RS10790	COG2814	Major facilitator Superfamily
C3K59_RS10795	COG3420	alginic acid biosynthetic process
C3K59_RS10805	COG0477	Major facilitator Superfamily
C3K59_RS10810	COG1335	isochorismatase
C3K59_RS10820	COG0004	ammonium transporteR
C3K59_RS10825	COG0347	Belongs to the P(II) protein family
C3K59_RS10830	COG0671	phosphoesterase, PA-phosphatase related
C3K59_RS10840	COG0739	heme binding
C3K59_RS10845	COG1247	-acetyltransferase
C3K59_RS10865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3K59_RS10870	COG0789	Transcriptional regulator
C3K59_RS10880	COG2910	NAD(P)H-binding
C3K59_RS10885	COG1959	2 iron, 2 sulfur cluster binding
C3K59_RS10895	COG0832	Belongs to the urease beta subunit family
C3K59_RS10900	COG0831	urea catabolic process
C3K59_RS10915	COG3237	CsbD-like
C3K59_RS10920	COG1994	Peptidase M50
C3K59_RS10930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3K59_RS10935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C3K59_RS10945	COG2304	oxidoreductase activity
C3K59_RS10955	COG2304	oxidoreductase activity
C3K59_RS10960	COG2385	sporulation resulting in formation of a cellular spore
C3K59_RS10965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3K59_RS10975	COG4836	Membrane
C3K59_RS10985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3K59_RS10990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3K59_RS10995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3K59_RS11000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3K59_RS11005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3K59_RS11010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C3K59_RS11020	COG0356	it plays a direct role in the translocation of protons across the membrane
C3K59_RS11030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3K59_RS11035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3K59_RS11040	COG4475	Protein of unknown function (DUF436)
C3K59_RS11045	COG0698	ribose 5-phosphate isomerase
C3K59_RS11050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C3K59_RS11055	COG1971	Probably functions as a manganese efflux pump
C3K59_RS11060	COG0009	L-threonylcarbamoyladenylate synthase
C3K59_RS11065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C3K59_RS11085	COG2890	protein-(glutamine-N5) methyltransferase activity
C3K59_RS11090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3K59_RS11095	COG0346	lactoylglutathione lyase activity
C3K59_RS11100	COG0789	Transcriptional regulator
C3K59_RS11105	COG0679	Auxin Efflux Carrier
C3K59_RS11110	COG0281	malic enzyme
C3K59_RS11115	COG1435	thymidine kinase activity
C3K59_RS11135	COG1494	fructose-1,6-bisphosphatase
C3K59_RS11140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3K59_RS11145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3K59_RS11150	COG0191	fructose-bisphosphate aldolase activity
C3K59_RS11155	COG2204	response regulator
C3K59_RS11160	COG4821	SIS domain
C3K59_RS11165	COG0504	CTP synthase activity
C3K59_RS11170	COG3343	RNA polymerase activity
C3K59_RS11175	COG1960	acyl-CoA dehydrogenase activity
C3K59_RS11180	COG2181	nitrate reductase activity
C3K59_RS11180	COG0247	lactate metabolic process
C3K59_RS11185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3K59_RS11190	COG4294	response to UV
C3K59_RS11200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3K59_RS11205	COG1132	(ABC) transporter
C3K59_RS11220	COG2181	nitrate reductase activity
C3K59_RS11225	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C3K59_RS11230	COG1140	nitrate reductase beta subunit
C3K59_RS11235	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C3K59_RS11240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3K59_RS11250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3K59_RS11255	COG2223	nitrite transmembrane transporter activity
C3K59_RS11260	COG0018	arginyl-trna synthetase
C3K59_RS11265	COG4506	Protein conserved in bacteria
C3K59_RS11275	COG0535	radical SAM domain protein
C3K59_RS11285	COG1131	(ABC) transporter
C3K59_RS11290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3K59_RS11295	COG0612	Peptidase, M16
C3K59_RS11300	COG0612	Peptidase, M16
C3K59_RS11310	COG3391	amine dehydrogenase activity
C3K59_RS11315	COG3391	amine dehydrogenase activity
C3K59_RS11325	COG0457	Tetratricopeptide repeat
C3K59_RS11355	COG1131	(ABC) transporter
C3K59_RS11365	COG0010	Belongs to the arginase family
C3K59_RS11370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C3K59_RS11375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3K59_RS11385	COG1994	Peptidase M50
C3K59_RS11390	COG1942	4-Oxalocrotonate Tautomerase
C3K59_RS11395	COG1846	Transcriptional regulator
C3K59_RS11400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3K59_RS11405	COG0477	Major facilitator Superfamily
C3K59_RS11410	COG1959	2 iron, 2 sulfur cluster binding
C3K59_RS11415	COG3465	dGTPase activity
C3K59_RS11420	COG1078	dGTPase activity
C3K59_RS11425	COG4844	belongs to the
C3K59_RS11435	COG0697	spore germination
C3K59_RS11440	COG0095	Lipoate-protein ligase
C3K59_RS11445	COG0583	DNA-binding transcription factor activity
C3K59_RS11450	COG0280	phosphate acetyltransferase
C3K59_RS11460	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS11465	COG0436	Aminotransferase
C3K59_RS11470	COG2814	Major facilitator Superfamily
C3K59_RS11475	COG0151	Belongs to the GarS family
C3K59_RS11480	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS11485	COG1917	Cupin 2, conserved barrel domain protein
C3K59_RS11490	COG0077	Prephenate dehydratase
C3K59_RS11495	COG2814	Major facilitator Superfamily
C3K59_RS11500	COG0833	amino acid
C3K59_RS11510	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS11515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3K59_RS11525	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C3K59_RS11530	COG1091	dTDP-4-dehydrorhamnose reductase activity
C3K59_RS11535	COG1088	dTDP-glucose 4,6-dehydratase activity
C3K59_RS11540	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C3K59_RS11545	COG3980	spore coat polysaccharide biosynthesis protein
C3K59_RS11550	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C3K59_RS11555	COG2089	acid synthase
C3K59_RS11560	COG0456	acetyltransferase
C3K59_RS11565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3K59_RS11570	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3K59_RS11575	COG0463	Glycosyl transferase, family 2
C3K59_RS11585	COG2363	Small membrane protein
C3K59_RS11590	COG2233	PERMEase
C3K59_RS11600	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS11605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3K59_RS11610	COG1216	Glycosyl transferase, family 2
C3K59_RS11615	COG0351	phosphomethylpyrimidine kinase
C3K59_RS11630	COG1263	PTS System
C3K59_RS11630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K59_RS11635	COG2116	formate transmembrane transporter activity
C3K59_RS11640	COG3711	transcriptional antiterminator
C3K59_RS11650	COG1404	Belongs to the peptidase S8 family
C3K59_RS11655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K59_RS11660	COG0778	Nitroreductase
C3K59_RS11665	COG0772	Belongs to the SEDS family
C3K59_RS11675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C3K59_RS11685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3K59_RS11690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3K59_RS11695	COG2261	transglycosylase associated protein
C3K59_RS11700	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C3K59_RS11705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C3K59_RS11710	COG2246	polysaccharide biosynthetic process
C3K59_RS11715	COG1309	transcriptional regulator
C3K59_RS11725	COG3162	membrane
C3K59_RS11730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3K59_RS11740	COG2837	iron assimilation
C3K59_RS11745	COG2822	iron ion transport
C3K59_RS11750	COG0672	)-iron permease
C3K59_RS11755	COG0352	thiamine-phosphate diphosphorylase activity
C3K59_RS11760	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C3K59_RS11765	COG0583	DNA-binding transcription factor activity
C3K59_RS11770	COG1380	Effector of murein hydrolase LrgA
C3K59_RS11775	COG1346	cytolysis
C3K59_RS11780	COG2814	Major facilitator Superfamily
C3K59_RS11785	COG4895	conserved protein (DUF2196)
C3K59_RS11790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C3K59_RS11795	COG0346	lactoylglutathione lyase activity
C3K59_RS11810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3K59_RS11815	COG1404	Belongs to the peptidase S8 family
C3K59_RS11820	COG1263	PTS System
C3K59_RS11820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K59_RS11825	COG3711	transcriptional antiterminator
C3K59_RS11830	COG1442	glycosyl transferase family 8
C3K59_RS11835	COG5522	Integral membrane protein (intg_mem_TP0381)
C3K59_RS11840	COG1846	Transcriptional regulator
C3K59_RS11845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3K59_RS11850	COG2234	aminopeptidase activity
C3K59_RS11865	COG2814	Major facilitator Superfamily
C3K59_RS11870	COG2357	RelA SpoT domain protein
C3K59_RS11875	COG1575	Belongs to the MenA family. Type 1 subfamily
C3K59_RS11890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS11895	COG1696	Membrane protein involved in D-alanine export
C3K59_RS11900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3K59_RS11905	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C3K59_RS11910	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C3K59_RS11915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3K59_RS11920	COG1486	melibiose metabolic process
C3K59_RS11925	COG1447	Phosphotransferase system cellobiose-specific component IIA
C3K59_RS11930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3K59_RS11935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3K59_RS11940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K59_RS11940	COG3711	transcriptional antiterminator
C3K59_RS11950	COG2094	Belongs to the DNA glycosylase MPG family
C3K59_RS11955	COG0753	catalase activity
C3K59_RS11960	COG2814	Major facilitator Superfamily
C3K59_RS11965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C3K59_RS11990	COG1595	DNA-templated transcription, initiation
C3K59_RS11995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C3K59_RS12000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3K59_RS12005	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C3K59_RS12015	COG1294	oxidase, subunit
C3K59_RS12020	COG1271	oxidase subunit
C3K59_RS12025	COG3493	citrate carrier protein
C3K59_RS12030	COG0501	Belongs to the peptidase M48B family
C3K59_RS12040	COG0726	polysaccharide deacetylase
C3K59_RS12045	COG3842	ATPase activity
C3K59_RS12050	COG2508	Transcriptional regulator
C3K59_RS12055	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS12060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3K59_RS12070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3K59_RS12080	COG4585	Histidine kinase
C3K59_RS12085	COG2197	response regulator
C3K59_RS12100	COG4894	glucomannan catabolic process
C3K59_RS12105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3K59_RS12110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3K59_RS12115	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS12120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C3K59_RS12125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C3K59_RS12130	COG2610	gluconate transmembrane transporter activity
C3K59_RS12135	COG0500	methyltransferase
C3K59_RS12140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C3K59_RS12155	COG0753	catalase activity
C3K59_RS12155	COG0693	protein deglycase activity
C3K59_RS12160	COG2851	Citrate transporter
C3K59_RS12165	COG2273	Hydrolase Family 16
C3K59_RS12170	COG3711	transcriptional antiterminator
C3K59_RS12185	COG0513	Belongs to the DEAD box helicase family
C3K59_RS12190	COG3401	FG-GAP repeat protein
C3K59_RS12190	COG2755	lipolytic protein G-D-S-L family
C3K59_RS12250	COG3209	COG3209 Rhs family protein
C3K59_RS12255	COG0697	spore germination
C3K59_RS12265	COG2723	6-phospho-beta-galactosidase activity
C3K59_RS12270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K59_RS12270	COG2190	(PTS) system
C3K59_RS12270	COG1263	PTS System
C3K59_RS12320	COG3507	Belongs to the glycosyl hydrolase 43 family
C3K59_RS12335	COG2986	histidine ammonia-lyase
C3K59_RS12340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C3K59_RS12345	COG1228	amidohydrolase
C3K59_RS12355	COG0833	amino acid
C3K59_RS12360	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C3K59_RS12365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C3K59_RS12370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C3K59_RS12375	COG2390	Transcriptional regulator
C3K59_RS12385	COG3192	ethanolamine utilization protein
C3K59_RS12395	COG1473	amidohydrolase
C3K59_RS12400	COG1126	abc transporter atp-binding protein
C3K59_RS12405	COG0765	amino acid transport
C3K59_RS12410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K59_RS12415	COG0456	acetyltransferase
C3K59_RS12420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K59_RS12425	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C3K59_RS12430	COG0561	phosphatase activity
C3K59_RS12460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3K59_RS12465	COG5294	Protein conserved in bacteria
C3K59_RS12470	COG0577	efflux transmembrane transporter activity
C3K59_RS12475	COG1136	(ABC) transporter
C3K59_RS12480	COG2205	protein histidine kinase activity
C3K59_RS12485	COG0745	RESPONSE REGULATOR receiver
C3K59_RS12490	COG0191	fructose-bisphosphate aldolase activity
C3K59_RS12495	COG1082	Xylose isomerase domain protein TIM barrel
C3K59_RS12500	COG1082	Xylose isomerase domain protein TIM barrel
C3K59_RS12505	COG0673	inositol 2-dehydrogenase activity
C3K59_RS12510	COG2814	Major facilitator Superfamily
C3K59_RS12515	COG1082	Xylose isomerase domain protein TIM barrel
C3K59_RS12520	COG3962	Belongs to the TPP enzyme family
C3K59_RS12525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3K59_RS12535	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS12540	COG1349	DNA-binding transcription factor activity
C3K59_RS12545	COG0667	Aldo Keto reductase
C3K59_RS12560	COG2814	Major facilitator Superfamily
C3K59_RS12565	COG0326	Molecular chaperone. Has ATPase activity
C3K59_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS12580	COG1309	transcriptional regulator
C3K59_RS12585	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS12590	COG1714	RDD family
C3K59_RS12595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C3K59_RS12605	COG1714	RDD family
C3K59_RS12610	COG2311	Membrane
C3K59_RS12615	COG1917	Cupin 2, conserved barrel domain protein
C3K59_RS12620	COG1309	transcriptional regulator
C3K59_RS12625	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS12630	COG1846	Transcriptional regulator
C3K59_RS12635	COG1380	Effector of murein hydrolase LrgA
C3K59_RS12640	COG1346	cytolysis
C3K59_RS12645	COG5039	Polysaccharide pyruvyl transferase
C3K59_RS12655	COG1802	Transcriptional regulator
C3K59_RS12660	COG1070	Carbohydrate kinase
C3K59_RS12670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3K59_RS12675	COG0450	alkyl hydroperoxide reductase
C3K59_RS12680	COG3634	alkyl hydroperoxide reductase activity
C3K59_RS12695	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C3K59_RS12710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C3K59_RS12745	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C3K59_RS12750	COG0456	acetyltransferase
C3K59_RS12765	COG0010	Belongs to the arginase family
C3K59_RS12770	COG0833	amino acid
C3K59_RS12775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3K59_RS12795	COG5658	integral membrane protein
C3K59_RS12800	COG0640	Transcriptional regulator
C3K59_RS12805	COG3829	transcription factor binding
C3K59_RS12820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3K59_RS12825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C3K59_RS12830	COG4853	Protein conserved in bacteria
C3K59_RS12835	COG4863	YycH protein
C3K59_RS12840	COG5002	protein histidine kinase activity
C3K59_RS12845	COG0745	RESPONSE REGULATOR receiver
C3K59_RS12875	COG0346	lactoylglutathione lyase activity
C3K59_RS12880	COG0305	Participates in initiation and elongation during chromosome replication
C3K59_RS12895	COG3093	addiction module antidote protein HigA
C3K59_RS12900	COG2807	transmembrane transport
C3K59_RS12905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C3K59_RS12910	COG0359	binds to the 23S rRNA
C3K59_RS12915	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C3K59_RS12920	COG4241	membrane
C3K59_RS12930	COG5577	PFAM Coat F domain
C3K59_RS12935	COG1733	regulation of RNA biosynthetic process
C3K59_RS12940	COG1227	inorganic diphosphatase activity
C3K59_RS12955	COG2271	Major facilitator Superfamily
C3K59_RS12960	COG4978	Transcriptional regulator
C3K59_RS12960	COG0789	Transcriptional regulator
C3K59_RS12970	COG4319	ketosteroid isomerase
C3K59_RS12975	COG1357	PFAM Pentapeptide repeats (8 copies)
C3K59_RS12980	COG2814	Major facilitator Superfamily
C3K59_RS12985	COG0583	DNA-binding transcription factor activity
C3K59_RS12990	COG2153	protein acetylation
C3K59_RS13005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3K59_RS13010	COG1846	Transcriptional regulator
C3K59_RS13015	COG2153	protein acetylation
C3K59_RS13020	COG2364	Membrane
C3K59_RS13025	COG0456	acetyltransferase
C3K59_RS13030	COG2315	Protein conserved in bacteria
C3K59_RS13035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3K59_RS13055	COG1331	Highly conserved protein containing a thioredoxin domain
C3K59_RS13060	COG0789	Transcriptional regulator
C3K59_RS13065	COG0697	spore germination
C3K59_RS13070	COG1331	Highly conserved protein containing a thioredoxin domain
C3K59_RS13075	COG1266	CAAX protease self-immunity
C3K59_RS13085	COG0110	maltose O-acetyltransferase activity
C3K59_RS13090	COG0346	lactoylglutathione lyase activity
C3K59_RS13095	COG1609	Transcriptional regulator
C3K59_RS13100	COG0708	Exodeoxyribonuclease III
C3K59_RS13105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3K59_RS13110	COG0629	single-stranded DNA binding
C3K59_RS13115	COG0360	Binds together with S18 to 16S ribosomal RNA
C3K59_RS13120	COG0012	GTP binding
C3K59_RS13125	COG0243	molybdopterin cofactor binding
C3K59_RS13130	COG4481	Protein conserved in bacteria
C3K59_RS13135	COG3949	Membrane
C3K59_RS13145	COG1475	DNA binding
C3K59_RS13150	COG1192	Involved in chromosome partitioning
C3K59_RS13160	COG1475	DNA binding
C3K59_RS13165	COG0357	Ribosomal RNA small subunit methyltransferase G
C3K59_RS13170	COG0445	tRNA wobble uridine modification
C3K59_RS13175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3K59_RS13180	COG1847	R3H domain protein
C3K59_RS13185	COG0706	membrane insertase activity
C3K59_RS13190	COG0594	ribonuclease P activity
C3K59_RS13200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3K59_RS13205	COG0592	DNA-directed DNA polymerase activity
C3K59_RS13210	COG2501	S4 domain
C3K59_RS13215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3K59_RS13225	COG0187	DNA topoisomerase II activity
C3K59_RS13230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3K59_RS13265	COG0516	GMP reductase activity
C3K59_RS13265	COG0517	IMP dehydrogenase activity
C3K59_RS13270	COG1686	Belongs to the peptidase S11 family
C3K59_RS13275	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C3K59_RS13280	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C3K59_RS13285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3K59_RS13295	COG1428	Deoxynucleoside kinase
C3K59_RS13300	COG1428	Deoxynucleoside kinase
C3K59_RS13305	COG3858	chitin binding
C3K59_RS13305	COG1388	LysM domain
C3K59_RS13310	COG1335	isochorismatase
C3K59_RS13315	COG0590	tRNA wobble adenosine to inosine editing
C3K59_RS13325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3K59_RS13330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C3K59_RS13335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3K59_RS13380	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C3K59_RS13385	COG3853	Toxic anion resistance protein (TelA)
C3K59_RS13390	COG1982	Orn Lys Arg decarboxylase major
C3K59_RS13395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C3K59_RS13400	COG3870	Protein conserved in bacteria
C3K59_RS13405	COG1728	Protein conserved in bacteria
C3K59_RS13410	COG0470	DNA polymerase III
C3K59_RS13415	COG1774	PSP1 C-terminal conserved region
C3K59_RS13420	COG4467	Involved in initiation control of chromosome replication
C3K59_RS13425	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C3K59_RS13430	COG2827	Endonuclease containing a URI domain
C3K59_RS13435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3K59_RS13440	COG2002	toxin-antitoxin pair type II binding
C3K59_RS13445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3K59_RS13445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3K59_RS13450	COG0084	hydrolase, TatD family'
C3K59_RS13455	COG3583	domain protein
C3K59_RS13455	COG3584	3D domain protein
C3K59_RS13460	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C3K59_RS13465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3K59_RS13475	COG4466	Protein conserved in bacteria
C3K59_RS13485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C3K59_RS13490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3K59_RS13495	COG0251	oxidation-reduction process
C3K59_RS13500	COG2088	sporulation resulting in formation of a cellular spore
C3K59_RS13505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3K59_RS13510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3K59_RS13515	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3K59_RS13520	COG0193	aminoacyl-tRNA hydrolase activity
C3K59_RS13535	COG2002	toxin-antitoxin pair type II binding
C3K59_RS13540	COG2244	polysaccharide biosynthetic process
C3K59_RS13550	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C3K59_RS13565	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C3K59_RS13570	COG1098	S1 RNA binding domain
C3K59_RS13585	COG2208	phosphoserine phosphatase activity
C3K59_RS13590	COG2304	oxidoreductase activity
C3K59_RS13600	COG0037	tRNA processing
C3K59_RS13610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3K59_RS13615	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C3K59_RS13620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C3K59_RS13625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3K59_RS13630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3K59_RS13635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C3K59_RS13640	COG0512	Glutamine amidotransferase of anthranilate synthase
C3K59_RS13645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3K59_RS13650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3K59_RS13655	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3K59_RS13660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C3K59_RS13665	COG1396	sequence-specific DNA binding
C3K59_RS13670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3K59_RS13675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C3K59_RS13755	COG4463	regulation of RNA biosynthetic process
C3K59_RS13760	COG3880	PFAM UvrB UvrC protein
C3K59_RS13765	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C3K59_RS13770	COG0542	response to heat
C3K59_RS13775	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C3K59_RS13780	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C3K59_RS13785	COG4956	integral membrane protein (PIN domain superfamily)
C3K59_RS13790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C3K59_RS13795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3K59_RS13800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3K59_RS13805	COG1045	serine acetyltransferase
C3K59_RS13810	COG0215	cysteine-tRNA ligase activity
C3K59_RS13815	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C3K59_RS13820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3K59_RS13825	COG3688	RNA-binding protein containing a PIN domain
C3K59_RS13830	COG1595	DNA-templated transcription, initiation
C3K59_RS13840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3K59_RS13845	COG0250	Participates in transcription elongation, termination and antitermination
C3K59_RS13855	COG0081	regulation of translation
C3K59_RS13860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3K59_RS13870	COG2813	Specifically methylates the guanine in position
C3K59_RS13875	COG0085	RNA polymerase activity
C3K59_RS13880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C3K59_RS13885	COG1358	cellular component organization or biogenesis
C3K59_RS13890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3K59_RS13895	COG0049	tRNA binding
C3K59_RS13900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3K59_RS13905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3K59_RS13920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C3K59_RS13925	COG0088	Forms part of the polypeptide exit tunnel
C3K59_RS13935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3K59_RS13950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3K59_RS13955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3K59_RS13965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3K59_RS13970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3K59_RS13980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C3K59_RS13990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3K59_RS13995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3K59_RS14000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3K59_RS14005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3K59_RS14015	COG0200	Binds to the 23S rRNA
C3K59_RS14020	COG0201	protein transport
C3K59_RS14025	COG0563	adenylate kinase activity
C3K59_RS14030	COG0024	Methionine aminopeptidase
C3K59_RS14035	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C3K59_RS14045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3K59_RS14050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3K59_RS14055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3K59_RS14060	COG0202	RNA polymerase activity
C3K59_RS14065	COG0203	ribosomal protein L17
C3K59_RS14070	COG1122	ATPase activity
C3K59_RS14075	COG1122	ATPase activity
C3K59_RS14080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C3K59_RS14085	COG0101	tRNA pseudouridine synthase activity
C3K59_RS14090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3K59_RS14095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3K59_RS14100	COG2226	methyltransferase
C3K59_RS14110	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS14115	COG0489	protein tyrosine kinase activity
C3K59_RS14130	COG0726	polysaccharide deacetylase
C3K59_RS14165	COG2856	Zn peptidase
C3K59_RS14180	COG1395	domain, Protein
C3K59_RS14240	COG0305	Participates in initiation and elongation during chromosome replication
C3K59_RS14345	COG1783	phage Terminase large subunit
C3K59_RS14350	COG5518	Phage portal protein
C3K59_RS14355	COG2369	cell adhesion
C3K59_RS14365	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C3K59_RS14370	COG4653	Phage capsid family
C3K59_RS14425	COG5280	Phage tail tape measure protein TP901
C3K59_RS14425	COG3953	SLT domain
C3K59_RS14430	COG1652	LysM domain
C3K59_RS14435	COG4193	domain, Protein
C3K59_RS14445	COG3628	GPW Gp25 family protein
C3K59_RS14450	COG3299	homolog of phage Mu protein gp47
C3K59_RS14455	COG3778	Protein conserved in bacteria
C3K59_RS14495	COG1388	LysM domain
C3K59_RS14495	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS14495	COG5632	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS14505	COG5444	nuclease activity
C3K59_RS14510	COG0457	Tetratricopeptide repeat
C3K59_RS14525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3K59_RS14585	COG0659	secondary active sulfate transmembrane transporter activity
C3K59_RS14590	COG0385	Bile acid
C3K59_RS14595	COG2819	hydrolase of the alpha beta superfamily
C3K59_RS14600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS14605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS14610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3K59_RS14615	COG2207	Transcriptional regulator
C3K59_RS14615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3K59_RS14620	COG3876	Protein conserved in bacteria
C3K59_RS14625	COG1472	Belongs to the glycosyl hydrolase 3 family
C3K59_RS14630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C3K59_RS14635	COG1263	PTS System
C3K59_RS14635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K59_RS14640	COG1737	Transcriptional regulator
C3K59_RS14645	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C3K59_RS14650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K59_RS14685	COG1595	DNA-templated transcription, initiation
C3K59_RS14690	COG5662	AntiSigma factor
C3K59_RS14695	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C3K59_RS14700	COG4856	YbbR-like protein
C3K59_RS14705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3K59_RS14710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3K59_RS14720	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C3K59_RS14725	COG2169	Transcriptional regulator
C3K59_RS14730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3K59_RS14740	COG3002	Belongs to the UPF0753 family
C3K59_RS14745	COG0288	reversible hydration of carbon dioxide
C3K59_RS14755	COG5609	conserved protein (DUF2294)
C3K59_RS14760	COG0640	Transcriptional regulator
C3K59_RS14780	COG1404	Belongs to the peptidase S8 family
C3K59_RS14800	COG1132	(ABC) transporter
C3K59_RS14805	COG1132	(ABC) transporter
C3K59_RS14810	COG0596	Alpha beta hydrolase
C3K59_RS14820	COG0642	Histidine kinase
C3K59_RS14830	COG0515	serine threonine protein kinase
C3K59_RS14845	COG1113	amino acid transport
C3K59_RS14865	COG2124	cytochrome p450
C3K59_RS14875	COG0531	amino acid
C3K59_RS14885	COG0584	glycerophosphoryl diester phosphodiesterase
C3K59_RS14890	COG2271	Major facilitator Superfamily
C3K59_RS14900	COG0456	acetyltransferase
C3K59_RS14900	COG1846	Transcriptional regulator
C3K59_RS14905	COG2271	Major facilitator Superfamily
C3K59_RS14915	COG1917	Cupin 2, conserved barrel domain protein
C3K59_RS14915	COG2207	Transcriptional regulator
C3K59_RS14920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C3K59_RS14925	COG3591	Belongs to the peptidase S1B family
C3K59_RS14935	COG0596	Alpha beta hydrolase
C3K59_RS14940	COG1183	phosphatidylcholine synthase activity
C3K59_RS14945	COG0586	Pfam SNARE associated Golgi protein
C3K59_RS14950	COG0688	phosphatidylethanolamine metabolic process
C3K59_RS14960	COG2312	Erythromycin esterase
C3K59_RS14970	COG1301	dicarboxylic acid transport
C3K59_RS14975	COG2190	(PTS) system
C3K59_RS14975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K59_RS14975	COG1263	PTS System
C3K59_RS14980	COG0363	glucosamine-6-phosphate deaminase activity
C3K59_RS14985	COG2188	Transcriptional regulator
C3K59_RS14995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3K59_RS15000	COG0833	amino acid
C3K59_RS15005	COG2040	homocysteine
C3K59_RS15015	COG1115	amino acid carrier protein
C3K59_RS15020	COG2066	Belongs to the glutaminase family
C3K59_RS15025	COG4191	Histidine kinase
C3K59_RS15030	COG0784	Response regulator, receiver
C3K59_RS15035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3K59_RS15040	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS15045	COG2271	Major facilitator Superfamily
C3K59_RS15050	COG4948	Mandelate Racemase Muconate Lactonizing
C3K59_RS15055	COG2186	Transcriptional regulator
C3K59_RS15065	COG3173	Aminoglycoside phosphotransferase
C3K59_RS15075	COG0697	spore germination
C3K59_RS15085	COG2205	protein histidine kinase activity
C3K59_RS15090	COG1131	(ABC) transporter
C3K59_RS15110	COG3773	Cell wall hydrolase
C3K59_RS15115	COG2304	oxidoreductase activity
C3K59_RS15125	COG3540	Alkaline phosphatase
C3K59_RS15130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3K59_RS15135	COG0805	protein transport
C3K59_RS15140	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C3K59_RS15145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3K59_RS15150	COG0477	Major facilitator Superfamily
C3K59_RS15155	COG1309	transcriptional regulator
C3K59_RS15160	COG0252	asparaginase activity
C3K59_RS15165	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C3K59_RS15170	COG1714	RDD family
C3K59_RS15175	COG1405	negative regulation of cell septum assembly
C3K59_RS15175	COG3012	SEC-C Motif Domain Protein
C3K59_RS15180	COG3290	protein histidine kinase activity
C3K59_RS15185	COG3279	Response regulator of the LytR AlgR family
C3K59_RS15190	COG4555	ABC transporter
C3K59_RS15195	COG1668	transmembrane transport
C3K59_RS15200	COG0667	Aldo Keto reductase
C3K59_RS15215	COG1595	DNA-templated transcription, initiation
C3K59_RS15220	COG1595	DNA-templated transcription, initiation
C3K59_RS15225	COG1876	peptidase activity
C3K59_RS15230	COG0457	Tetratricopeptide repeat
C3K59_RS15235	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS15240	COG0366	Alpha amylase catalytic
C3K59_RS15245	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3K59_RS15250	COG1121	(ABC) transporter
C3K59_RS15255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3K59_RS15260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K59_RS15265	COG2310	stress, protein
C3K59_RS15270	COG2310	stress, protein
C3K59_RS15275	COG2310	stress, protein
C3K59_RS15280	COG0861	Integral membrane protein TerC family
C3K59_RS15290	COG3853	Toxic anion resistance protein (TelA)
C3K59_RS15295	COG0477	Major facilitator Superfamily
C3K59_RS15305	COG0640	Transcriptional regulator
C3K59_RS15310	COG0517	IMP dehydrogenase activity
C3K59_RS15310	COG4175	Glycine betaine
C3K59_RS15315	COG4176	ABC-type proline glycine betaine transport system permease component
C3K59_RS15320	COG2113	Glycine betaine
C3K59_RS15325	COG1473	amidohydrolase
C3K59_RS15330	COG1288	antiporter activity
C3K59_RS15340	COG0366	Alpha amylase catalytic
C3K59_RS15345	COG0039	L-malate dehydrogenase activity
C3K59_RS15350	COG1620	l-lactate permease
C3K59_RS15355	COG2814	Major facilitator Superfamily
C3K59_RS15360	COG1846	Transcriptional regulator
C3K59_RS15370	COG3403	YqcI/YcgG family
C3K59_RS15375	COG1113	amino acid transport
C3K59_RS15380	COG3665	Urea carboxylase-associated protein
C3K59_RS15385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3K59_RS15390	COG1660	Displays ATPase and GTPase activities
C3K59_RS15395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3K59_RS15400	COG2226	methyltransferase
C3K59_RS15405	COG0583	DNA-binding transcription factor activity
C3K59_RS15410	COG3458	cephalosporin-C deacetylase activity
C3K59_RS15415	COG3541	Predicted nucleotidyltransferase
C3K59_RS15420	COG0506	proline dehydrogenase activity
C3K59_RS15425	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS15430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3K59_RS15435	COG2508	Transcriptional regulator
C3K59_RS15440	COG3689	TIGRFAM TIGR03943 family protein
C3K59_RS15445	COG0701	Predicted permease
C3K59_RS15450	COG2267	carboxylic ester hydrolase activity
C3K59_RS15460	COG1587	Uroporphyrinogen-III synthase
C3K59_RS15460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C3K59_RS15465	COG2146	nitrite reductase [NAD(P)H] activity
C3K59_RS15470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3K59_RS15480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3K59_RS15485	COG2223	nitrite transmembrane transporter activity
C3K59_RS15490	COG1469	GTP cyclohydrolase I activity
C3K59_RS15495	COG1376	ErfK ybiS ycfS ynhG family protein
C3K59_RS15510	COG0765	amino acid transport
C3K59_RS15515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K59_RS15535	COG2723	6-phospho-beta-galactosidase activity
C3K59_RS15545	COG3209	COG3209 Rhs family protein
C3K59_RS15550	COG0840	transmembrane signaling receptor activity
C3K59_RS15550	COG3290	protein histidine kinase activity
C3K59_RS15555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C3K59_RS15560	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C3K59_RS15565	COG1733	regulation of RNA biosynthetic process
C3K59_RS15570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS15575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS15580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS15585	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C3K59_RS15590	COG2814	Major facilitator Superfamily
C3K59_RS15600	COG0697	spore germination
C3K59_RS15615	COG2364	Membrane
C3K59_RS15620	COG1126	abc transporter atp-binding protein
C3K59_RS15625	COG0765	amino acid transport
C3K59_RS15630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3K59_RS15635	COG0583	DNA-binding transcription factor activity
C3K59_RS15640	COG0163	prenyltransferase activity
C3K59_RS15645	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C3K59_RS15660	COG0596	Alpha beta hydrolase
C3K59_RS15665	COG3104	oligopeptide transport
C3K59_RS15670	COG5434	Belongs to the glycosyl hydrolase 28 family
C3K59_RS15680	COG0697	spore germination
C3K59_RS15690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C3K59_RS15695	COG1136	(ABC) transporter
C3K59_RS15700	COG0577	efflux transmembrane transporter activity
C3K59_RS15705	COG0745	RESPONSE REGULATOR receiver
C3K59_RS15710	COG3850	Histidine kinase
C3K59_RS15710	COG5002	protein histidine kinase activity
C3K59_RS15715	COG0457	Tetratricopeptide repeat
C3K59_RS15735	COG0527	aspartate kinase activity
C3K59_RS15740	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS15745	COG4605	iron ion homeostasis
C3K59_RS15750	COG4604	ABC transporter, ATP-binding protein
C3K59_RS15755	COG4607	ABC-type enterochelin transport system periplasmic component
C3K59_RS15760	COG2814	Major facilitator Superfamily
C3K59_RS15765	COG1309	transcriptional regulator
C3K59_RS15770	COG0778	Nitroreductase
C3K59_RS15775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C3K59_RS15780	COG0640	Transcriptional regulator
C3K59_RS15785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K59_RS15790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3K59_RS15795	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS15805	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS15810	COG4549	nuclear export factor GLE1
C3K59_RS15815	COG2372	response to copper ion
C3K59_RS15815	COG1276	copper resistance
C3K59_RS15820	COG1349	DNA-binding transcription factor activity
C3K59_RS15830	COG2213	PTS system mannitol-specific
C3K59_RS15835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K59_RS15840	COG0246	Mannitol dehydrogenase
C3K59_RS15845	COG0473	3-isopropylmalate dehydrogenase activity
C3K59_RS15850	COG0681	Belongs to the peptidase S26 family
C3K59_RS15855	COG0412	Dienelactone hydrolase
C3K59_RS15860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3K59_RS15870	COG0561	phosphatase activity
C3K59_RS15875	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C3K59_RS15880	COG1914	H( )-stimulated, divalent metal cation uptake system
C3K59_RS15885	COG4336	lyase activity
C3K59_RS15890	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C3K59_RS15895	COG1984	allophanate hydrolase subunit 2
C3K59_RS15905	COG2755	lipolytic protein G-D-S-L family
C3K59_RS15915	COG2329	Antibiotic biosynthesis monooxygenase
C3K59_RS15920	COG0768	penicillin binding
C3K59_RS15925	COG4989	oxidoreductase activity
C3K59_RS15930	COG3711	transcriptional antiterminator
C3K59_RS15935	COG0318	PFAM AMP-dependent synthetase and ligase
C3K59_RS15940	COG2226	methyltransferase
C3K59_RS15945	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS15950	COG1917	Cupin 2, conserved barrel domain protein
C3K59_RS15955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K59_RS15960	COG3871	stress protein (general stress protein 26)
C3K59_RS15970	COG2814	Major facilitator Superfamily
C3K59_RS15975	COG1522	sequence-specific DNA binding
C3K59_RS15980	COG0551	DNA topoisomerase type I activity
C3K59_RS15980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3K59_RS15985	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C3K59_RS15990	COG3706	GGDEF domain
C3K59_RS16000	COG1215	transferase activity, transferring glycosyl groups
C3K59_RS16010	COG0531	amino acid
C3K59_RS16015	COG0494	nUDIX hydrolase
C3K59_RS16020	COG0028	Belongs to the TPP enzyme family
C3K59_RS16035	COG1914	H( )-stimulated, divalent metal cation uptake system
C3K59_RS16040	COG2261	transglycosylase associated protein
C3K59_RS16045	COG4876	unkown
C3K59_RS16050	COG2217	Heavy metal translocating P-type atpase
C3K59_RS16055	COG3729	General stress protein
C3K59_RS16060	COG0662	Cupin 2, conserved barrel domain protein
C3K59_RS16065	COG2329	Antibiotic biosynthesis monooxygenase
C3K59_RS16070	COG3546	catalase activity
C3K59_RS16075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C3K59_RS16080	COG3290	protein histidine kinase activity
C3K59_RS16085	COG4565	transcriptional regulatory protein
C3K59_RS16090	COG1301	dicarboxylic acid transport
C3K59_RS16095	COG0628	permease
C3K59_RS16100	COG1131	(ABC) transporter
C3K59_RS16105	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C3K59_RS16115	COG1960	acyl-CoA dehydrogenase activity
C3K59_RS16130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3K59_RS16135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS16140	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3K59_RS16145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3K59_RS16150	COG0513	Belongs to the DEAD box helicase family
C3K59_RS16155	COG3402	PFAM membrane-flanked domain
C3K59_RS16160	COG3428	Bacterial PH domain
C3K59_RS16165	COG0705	Rhomboid family
C3K59_RS16170	COG0736	holo-[acyl-carrier-protein] synthase activity
C3K59_RS16175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C3K59_RS16180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C3K59_RS16185	COG0864	Transcriptional regulator
C3K59_RS16190	COG2337	Toxic component of a toxin-antitoxin (TA) module
C3K59_RS16195	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K59_RS16200	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K59_RS16205	COG2172	sigma factor antagonist activity
C3K59_RS16210	COG2208	phosphoserine phosphatase activity
C3K59_RS16215	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K59_RS16220	COG2172	sigma factor antagonist activity
C3K59_RS16225	COG1191	sigma factor activity
C3K59_RS16230	COG2208	phosphoserine phosphatase activity
C3K59_RS16235	COG2183	response to ionizing radiation
C3K59_RS16245	COG3091	SprT-like family
C3K59_RS16295	COG1476	TRANSCRIPTIONal
C3K59_RS16320	COG0693	protein deglycase activity
C3K59_RS16325	COG1278	Cold shock
C3K59_RS16330	COG1329	Transcriptional regulator
C3K59_RS16335	COG0697	spore germination
C3K59_RS16340	COG1917	Cupin 2, conserved barrel domain protein
C3K59_RS16340	COG2207	Transcriptional regulator
C3K59_RS16345	COG0697	spore germination
C3K59_RS16350	COG3708	Transcriptional regulator
C3K59_RS16350	COG2207	Transcriptional regulator
C3K59_RS16355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K59_RS16360	COG0477	Major facilitator Superfamily
C3K59_RS16370	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C3K59_RS16385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K59_RS16390	COG1309	transcriptional regulator
C3K59_RS16400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K59_RS16405	COG2030	dehydratase
C3K59_RS16410	COG3545	Serine hydrolase
C3K59_RS16415	COG1733	regulation of RNA biosynthetic process
C3K59_RS16420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3K59_RS16425	COG2814	Major facilitator Superfamily
C3K59_RS16430	COG1309	transcriptional regulator
C3K59_RS16440	COG0640	Transcriptional regulator
C3K59_RS16445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C3K59_RS16455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K59_RS16460	COG0697	spore germination
C3K59_RS16465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K59_RS16470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C3K59_RS16475	COG0640	Transcriptional regulator
C3K59_RS16480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C3K59_RS16500	COG2197	response regulator
C3K59_RS16505	COG2409	Drug exporters of the RND superfamily
C3K59_RS16510	COG0596	Alpha beta hydrolase
C3K59_RS16515	COG1811	Na channel or pump
C3K59_RS16520	COG4978	Transcriptional regulator
C3K59_RS16520	COG0789	Transcriptional regulator
C3K59_RS16525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3K59_RS16530	COG0778	Nitroreductase
C3K59_RS16535	COG0346	lactoylglutathione lyase activity
C3K59_RS16540	COG2259	Doxx family
C3K59_RS16545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS16565	COG2323	membrane
C3K59_RS16570	COG2323	membrane
C3K59_RS16575	COG0071	Belongs to the small heat shock protein (HSP20) family
C3K59_RS16590	COG1309	transcriptional regulator
C3K59_RS16610	COG1113	amino acid transport
C3K59_RS16615	COG2318	DinB family
C3K59_RS16620	COG1846	Transcriptional regulator
C3K59_RS16625	COG1033	growth of symbiont in host cell
C3K59_RS16625	COG2409	Drug exporters of the RND superfamily
C3K59_RS16630	COG0778	Nitroreductase
C3K59_RS16635	COG1846	Transcriptional regulator
C3K59_RS16640	COG2814	Major facilitator Superfamily
C3K59_RS16645	COG0730	response to heat
C3K59_RS16650	COG1802	Transcriptional regulator
C3K59_RS16670	COG1785	Belongs to the alkaline phosphatase family
C3K59_RS16675	COG5646	InterPro IPR014922
C3K59_RS16685	COG0454	-acetyltransferase
C3K59_RS16690	COG1078	dGTPase activity
C3K59_RS16695	COG1388	LysM domain
C3K59_RS16700	COG2814	Major facilitator Superfamily
C3K59_RS16705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3K59_RS16710	COG1447	Phosphotransferase system cellobiose-specific component IIA
C3K59_RS16715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3K59_RS16720	COG2723	6-phospho-beta-galactosidase activity
C3K59_RS16725	COG2188	Transcriptional regulator
C3K59_RS16730	COG1940	carbohydrate kinase activity
C3K59_RS16735	COG1482	cell wall glycoprotein biosynthetic process
C3K59_RS16740	COG4124	Belongs to the glycosyl hydrolase 26 family
C3K59_RS16785	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C3K59_RS16790	COG0802	atpase or kinase
C3K59_RS16795	COG1214	PFAM Peptidase M22, glycoprotease
C3K59_RS16800	COG0456	acetyltransferase
C3K59_RS16805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C3K59_RS16810	COG0488	(ABC) transporter
C3K59_RS16815	COG0315	cyclic pyranopterin monophosphate synthase activity
C3K59_RS16820	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C3K59_RS16825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3K59_RS16830	COG0805	protein transport
C3K59_RS16840	COG1266	CAAX protease self-immunity
C3K59_RS16850	COG0459	protein refolding
C3K59_RS16855	COG4974	Belongs to the 'phage' integrase family
C3K59_RS16860	COG2856	Zn peptidase
C3K59_RS16875	COG1396	sequence-specific DNA binding
C3K59_RS16915	COG5377	YqaJ viral recombinase family
C3K59_RS16920	COG3723	Recombinational DNA repair protein, rece pathway
C3K59_RS16930	COG3935	DnaD domain protein
C3K59_RS16935	COG1484	DNA-dependent DNA replication
C3K59_RS17030	COG3677	Transposase
C3K59_RS17170	COG5632	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS17170	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS17215	COG1073	alpha beta
C3K59_RS17220	COG0457	Tetratricopeptide repeat
C3K59_RS17225	COG1063	alcohol dehydrogenase
C3K59_RS17230	COG2211	Major facilitator Superfamily
C3K59_RS17235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3K59_RS17240	COG1842	Phage shock protein A
C3K59_RS17245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3K59_RS17255	COG4260	virion core protein, lumpy skin disease virus
C3K59_RS17265	COG2814	Major facilitator Superfamily
C3K59_RS17270	COG1063	alcohol dehydrogenase
C3K59_RS17275	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C3K59_RS17280	COG0823	Involved in the tonB-independent uptake of proteins
C3K59_RS17295	COG2267	carboxylic ester hydrolase activity
C3K59_RS17305	COG2132	Multicopper oxidase
C3K59_RS17310	COG1113	amino acid transport
C3K59_RS17320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3K59_RS17325	COG0714	Associated with various cellular activities
C3K59_RS17330	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C3K59_RS17335	COG1305	Transglutaminase-like
C3K59_RS17340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3K59_RS17340	COG0519	Catalyzes the synthesis of GMP from XMP
C3K59_RS17355	COG2252	PERMEase
C3K59_RS17360	COG3064	Membrane
C3K59_RS17370	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C3K59_RS17380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C3K59_RS17385	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C3K59_RS17390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C3K59_RS17395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C3K59_RS17400	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3K59_RS17405	COG0047	phosphoribosylformylglycinamidine synthase activity
C3K59_RS17410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3K59_RS17415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C3K59_RS17420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3K59_RS17425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C3K59_RS17430	COG0138	bifunctional purine biosynthesis protein purh
C3K59_RS17435	COG0151	Belongs to the GarS family
C3K59_RS17440	COG1522	sequence-specific DNA binding
C3K59_RS17445	COG0531	amino acid
C3K59_RS17455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C3K59_RS17460	COG1470	cell adhesion involved in biofilm formation
C3K59_RS17465	COG4496	protein, YerC YecD
C3K59_RS17470	COG0069	glutamate synthase activity
C3K59_RS17475	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C3K59_RS17480	COG0210	DNA helicase
C3K59_RS17485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C3K59_RS17495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3K59_RS17505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3K59_RS17510	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3K59_RS17515	COG0154	amidase activity
C3K59_RS17520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3K59_RS17525	COG1309	transcriptional regulator
C3K59_RS17530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3K59_RS17535	COG1597	lipid kinase activity
C3K59_RS17540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3K59_RS17550	COG0457	Tetratricopeptide repeat
C3K59_RS17565	COG5444	nuclease activity
C3K59_RS17570	COG3391	amine dehydrogenase activity
C3K59_RS17580	COG0457	Tetratricopeptide repeat
C3K59_RS17590	COG0217	transcriptional regulatory protein
C3K59_RS17600	COG1309	transcriptional regulator
C3K59_RS17605	COG3631	Ketosteroid isomerase-related protein
C3K59_RS17610	COG0702	epimerase
C3K59_RS17625	COG3546	catalase activity
C3K59_RS17630	COG0454	-acetyltransferase
C3K59_RS17640	COG5578	integral membrane protein
C3K59_RS17645	COG2972	Histidine kinase
C3K59_RS17650	COG2207	Transcriptional regulator
C3K59_RS17650	COG4753	response regulator
C3K59_RS17655	COG1653	transport
C3K59_RS17660	COG1175	transmembrane transport
C3K59_RS17665	COG0395	ABC-type sugar transport system, permease component
C3K59_RS17670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C3K59_RS17675	COG2207	Transcriptional regulator
C3K59_RS17680	COG2755	lipolytic protein G-D-S-L family
C3K59_RS17690	COG5578	integral membrane protein
C3K59_RS17695	COG3401	FG-GAP repeat protein
C3K59_RS17700	COG3401	FG-GAP repeat protein
C3K59_RS17705	COG2755	lipolytic protein G-D-S-L family
C3K59_RS17710	COG1874	Beta-galactosidase
C3K59_RS17720	COG1653	transport
C3K59_RS17725	COG4209	transmembrane transport
C3K59_RS17730	COG0395	ABC-type sugar transport system, permease component
C3K59_RS17735	COG1486	melibiose metabolic process
C3K59_RS17740	COG2323	membrane
C3K59_RS17745	COG2329	Antibiotic biosynthesis monooxygenase
C3K59_RS17750	COG0346	lactoylglutathione lyase activity
C3K59_RS17765	COG5583	Uncharacterized small protein (DUF2292)
C3K59_RS17770	COG0670	Belongs to the BI1 family
C3K59_RS17775	COG0697	spore germination
C3K59_RS17780	COG1846	Transcriptional regulator
C3K59_RS17785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3K59_RS17800	COG2124	cytochrome p450
C3K59_RS17800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C3K59_RS17805	COG1368	sulfuric ester hydrolase activity
C3K59_RS17810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C3K59_RS17815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3K59_RS17820	COG1442	glycosyl transferase family 8
C3K59_RS17825	COG1216	Glycosyl transferase, family 2
C3K59_RS17830	COG1442	glycosyl transferase family 8
C3K59_RS17835	COG2223	nitrite transmembrane transporter activity
C3K59_RS17840	COG1011	Hydrolase
C3K59_RS17845	COG0531	amino acid
C3K59_RS17850	COG1012	belongs to the aldehyde dehydrogenase family
C3K59_RS17855	COG0840	transmembrane signaling receptor activity
C3K59_RS17860	COG0488	(ABC) transporter
C3K59_RS17870	COG0789	Transcriptional regulator
C3K59_RS17875	COG2814	Major facilitator Superfamily
C3K59_RS17885	COG0488	(ABC) transporter
C3K59_RS17890	COG0513	Belongs to the DEAD box helicase family
C3K59_RS17895	COG0456	acetyltransferase
C3K59_RS17900	COG2130	NADP-dependent
C3K59_RS17905	COG2211	Major facilitator Superfamily
C3K59_RS17910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C3K59_RS17915	COG1120	ATPase activity
C3K59_RS17920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS17925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS17930	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C3K59_RS17945	COG3866	Pectate lyase
C3K59_RS17950	COG0471	metal ion transport
C3K59_RS17960	COG4565	transcriptional regulatory protein
C3K59_RS17965	COG3181	Tripartite tricarboxylate transporter family receptor
C3K59_RS17970	COG2851	Citrate transporter
C3K59_RS17975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3K59_RS17980	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C3K59_RS17985	COG1254	Belongs to the acylphosphatase family
C3K59_RS17990	COG2258	MOSC domain
C3K59_RS18010	COG0024	Methionine aminopeptidase
C3K59_RS18020	COG1368	sulfuric ester hydrolase activity
C3K59_RS18035	COG1115	amino acid carrier protein
C3K59_RS18040	COG0531	amino acid
C3K59_RS18055	COG0697	spore germination
C3K59_RS18060	COG1263	PTS System
C3K59_RS18060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K59_RS18065	COG0366	Alpha amylase catalytic
C3K59_RS18070	COG2188	Transcriptional regulator
C3K59_RS18075	COG0778	Nitroreductase
C3K59_RS18080	COG0737	Belongs to the 5'-nucleotidase family
C3K59_RS18085	COG0693	protein deglycase activity
C3K59_RS18090	COG2814	Major facilitator Superfamily
C3K59_RS18095	COG4840	Belongs to the UPF0435 family
C3K59_RS18105	COG4980	gas vesicle protein
C3K59_RS18110	COG1295	ribonuclease BN
C3K59_RS18115	COG0477	Major facilitator Superfamily
C3K59_RS18120	COG0387	Pfam Sodium calcium exchanger
C3K59_RS18130	COG0668	transmembrane transport
C3K59_RS18135	COG0535	radical SAM domain protein
C3K59_RS18145	COG0726	polysaccharide deacetylase
C3K59_RS18150	COG2084	Dehydrogenase
C3K59_RS18155	COG0598	Magnesium transport protein CorA
C3K59_RS18160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C3K59_RS18165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3K59_RS18175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3K59_RS18180	COG4637	Psort location Cytoplasmic, score
C3K59_RS18185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3K59_RS18190	COG0022	dehydrogenase e1 component
C3K59_RS18195	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3K59_RS18200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3K59_RS18205	COG3284	Transcriptional regulator
C3K59_RS18215	COG1742	UPF0060 membrane protein
C3K59_RS18235	COG4842	Belongs to the WXG100 family
C3K59_RS18240	COG1486	melibiose metabolic process
C3K59_RS18245	COG1737	Transcriptional regulator
C3K59_RS18250	COG1263	PTS System
C3K59_RS18250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K59_RS18255	COG1132	(ABC) transporter
C3K59_RS18260	COG1132	(ABC) transporter
C3K59_RS18265	COG2259	Doxx family
C3K59_RS18275	COG4585	Histidine kinase
C3K59_RS18280	COG2197	response regulator
C3K59_RS18290	COG1511	domain protein
C3K59_RS18290	COG0842	Transport permease protein
C3K59_RS18295	COG0842	Transport permease protein
C3K59_RS18300	COG1695	Transcriptional regulator
C3K59_RS18305	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C3K59_RS18310	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C3K59_RS18315	COG2318	DinB family
C3K59_RS18320	COG2814	Major facilitator Superfamily
C3K59_RS18325	COG1846	Transcriptional regulator
C3K59_RS18330	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C3K59_RS18330	COG0392	lysyltransferase activity
C3K59_RS18335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3K59_RS18340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS18345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3K59_RS18350	COG0384	phenazine biosynthesis protein PhzF
C3K59_RS18355	COG0778	Nitroreductase
C3K59_RS18370	COG1090	epimerase
C3K59_RS18375	COG2137	regulation of response to DNA damage stimulus
C3K59_RS18400	COG3103	Sh3 type 3 domain protein
C3K59_RS18405	COG5658	integral membrane protein
C3K59_RS18410	COG0596	Alpha beta hydrolase
C3K59_RS18415	COG0463	Glycosyl transferase, family 2
C3K59_RS18420	COG4485	Bacterial membrane protein, YfhO
C3K59_RS18425	COG1988	membrane-bound metal-dependent
C3K59_RS18430	COG1194	a g-specific adenine glycosylase
C3K59_RS18440	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS18455	COG3557	Belongs to the UPF0374 family
C3K59_RS18460	COG1132	(ABC) transporter
C3K59_RS18465	COG4129	membrane
C3K59_RS18470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3K59_RS18475	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C3K59_RS18480	COG0735	belongs to the Fur family
C3K59_RS18590	COG4326	sporulation control protein
C3K59_RS18600	COG5577	PFAM Coat F domain
C3K59_RS18605	COG3340	Belongs to the peptidase S51 family
C3K59_RS18610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C3K59_RS18615	COG0277	FAD linked oxidase domain protein
C3K59_RS18625	COG0753	catalase activity
C3K59_RS18630	COG1116	anion transmembrane transporter activity
C3K59_RS18635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3K59_RS18640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3K59_RS18645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3K59_RS18655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3K59_RS18665	COG1476	TRANSCRIPTIONal
C3K59_RS18675	COG3382	B3 4 domain protein
C3K59_RS18680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C3K59_RS18690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3K59_RS18695	COG0789	Transcriptional regulator
C3K59_RS18700	COG1664	Polymer-forming cytoskeletal
C3K59_RS18705	COG1664	Polymer-forming cytoskeletal
C3K59_RS18710	COG2766	serine protein kinase
C3K59_RS18715	COG2718	Belongs to the UPF0229 family
C3K59_RS18720	COG1846	Transcriptional regulator
C3K59_RS18725	COG1566	PFAM secretion protein HlyD family protein
C3K59_RS18735	COG0655	NAD(P)H dehydrogenase (quinone) activity
C3K59_RS18755	COG1725	Transcriptional regulator
C3K59_RS18760	COG1131	(ABC) transporter
C3K59_RS18765	COG1131	(ABC) transporter
C3K59_RS18770	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C3K59_RS18775	COG1278	Cold shock
C3K59_RS18780	COG1464	Belongs to the NlpA lipoprotein family
C3K59_RS18785	COG3706	GGDEF domain
C3K59_RS18810	COG5577	PFAM Coat F domain
C3K59_RS18815	COG4085	toxin activity
C3K59_RS18815	COG1525	nuclease
C3K59_RS18815	COG0737	Belongs to the 5'-nucleotidase family
C3K59_RS18820	COG3764	Sortase (surface protein transpeptidase)
C3K59_RS18825	COG0564	pseudouridine synthase activity
C3K59_RS18835	COG0517	IMP dehydrogenase activity
C3K59_RS18840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3K59_RS18845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3K59_RS18845	COG3153	acetyltransferase
C3K59_RS18850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3K59_RS18860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C3K59_RS18865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3K59_RS18870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3K59_RS18875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3K59_RS18880	COG4585	Histidine kinase
C3K59_RS18880	COG2203	Gaf domain
C3K59_RS18885	COG2197	response regulator
C3K59_RS18890	COG0431	NADPH-dependent FMN reductase
C3K59_RS18905	COG0791	NLP P60 protein
C3K59_RS18905	COG1388	LysM domain
C3K59_RS18910	COG1959	2 iron, 2 sulfur cluster binding
C3K59_RS18915	COG0668	transmembrane transport
C3K59_RS18920	COG2719	SpoVR family
C3K59_RS18925	COG1785	Belongs to the alkaline phosphatase family
C3K59_RS18930	COG1388	LysM domain
C3K59_RS18930	COG0791	NLP P60 protein
C3K59_RS18935	COG0583	DNA-binding transcription factor activity
C3K59_RS18940	COG0372	Belongs to the citrate synthase family
C3K59_RS18945	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS18950	COG0531	amino acid
C3K59_RS18955	COG0733	neurotransmitter:sodium symporter activity
C3K59_RS18960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K59_RS18965	COG0456	acetyltransferase
C3K59_RS18980	COG1595	DNA-templated transcription, initiation
C3K59_RS18990	COG0204	Acyl-transferase
C3K59_RS18995	COG1253	flavin adenine dinucleotide binding
C3K59_RS19000	COG0789	Transcriptional regulator
C3K59_RS19005	COG0436	Aminotransferase
C3K59_RS19010	COG1253	flavin adenine dinucleotide binding
C3K59_RS19015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3K59_RS19020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3K59_RS19025	COG0584	glycerophosphoryl diester phosphodiesterase
C3K59_RS19035	COG0668	transmembrane transport
C3K59_RS19040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C3K59_RS19045	COG0726	polysaccharide deacetylase
C3K59_RS19050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3K59_RS19055	COG1757	Na H antiporter
C3K59_RS19060	COG0589	response to stress
C3K59_RS19070	COG1132	(ABC) transporter
C3K59_RS19075	COG1132	(ABC) transporter
C3K59_RS19080	COG0702	epimerase
C3K59_RS19100	COG0189	ligase activity
C3K59_RS19105	COG0189	ligase activity
C3K59_RS19110	COG4399	Belongs to the UPF0754 family
C3K59_RS19115	COG3679	Belongs to the UPF0342 family
C3K59_RS19120	COG4335	DNA alkylation repair
C3K59_RS19125	COG0561	phosphatase activity
C3K59_RS19130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3K59_RS19135	COG0475	glutathione-regulated potassium exporter activity
C3K59_RS19140	COG0490	domain, Protein
C3K59_RS19150	COG1024	Enoyl-CoA hydratase
C3K59_RS19160	COG4152	abc transporter atp-binding protein
C3K59_RS19165	COG1668	transmembrane transport
C3K59_RS19170	COG0420	3'-5' exonuclease activity
C3K59_RS19175	COG4717	serine-type aminopeptidase activity
C3K59_RS19180	COG3481	metal-dependent phosphohydrolase, HD sub domain
C3K59_RS19190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3K59_RS19220	COG1846	Transcriptional regulator
C3K59_RS19225	COG4980	gas vesicle protein
C3K59_RS19240	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C3K59_RS19245	COG0537	adenosine 5'-monophosphoramidase activity
C3K59_RS19250	COG1131	(ABC) transporter
C3K59_RS19255	COG4473	ABC transporter
C3K59_RS19265	COG1473	amidohydrolase
C3K59_RS19270	COG3069	C4-dicarboxylate transmembrane transporter activity
C3K59_RS19280	COG2329	Antibiotic biosynthesis monooxygenase
C3K59_RS19285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3K59_RS19290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3K59_RS19305	COG1309	transcriptional regulator
C3K59_RS19310	COG1511	domain protein
C3K59_RS19315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3K59_RS19320	COG4377	Putative membrane peptidase family (DUF2324)
C3K59_RS19330	COG1363	Peptidase, m42
C3K59_RS19335	COG4405	Protein conserved in bacteria
C3K59_RS19340	COG1301	dicarboxylic acid transport
C3K59_RS19350	COG1234	tRNA 3'-trailer cleavage
C3K59_RS19355	COG0095	Lipoate-protein ligase
C3K59_RS19360	COG0702	epimerase
C3K59_RS19365	COG0318	PFAM AMP-dependent synthetase and ligase
C3K59_RS19375	COG0501	Belongs to the peptidase M48B family
C3K59_RS19380	COG1404	Belongs to the peptidase S8 family
C3K59_RS19385	COG0456	acetyltransferase
C3K59_RS19390	COG0604	alcohol dehydrogenase
C3K59_RS19395	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C3K59_RS19400	COG0406	alpha-ribazole phosphatase activity
C3K59_RS19405	COG0183	Belongs to the thiolase family
C3K59_RS19410	COG0318	PFAM AMP-dependent synthetase and ligase
C3K59_RS19415	COG1268	BioY protein
C3K59_RS19420	COG0840	transmembrane signaling receptor activity
C3K59_RS19425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3K59_RS19425	COG0723	plastoquinol--plastocyanin reductase activity
C3K59_RS19430	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS19440	COG4903	ComK protein
C3K59_RS19445	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS19455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3K59_RS19475	COG0681	Belongs to the peptidase S26 family
C3K59_RS19480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C3K59_RS19490	COG0738	Major facilitator superfamily
C3K59_RS19495	COG0673	inositol 2-dehydrogenase activity
C3K59_RS19500	COG0561	phosphatase activity
C3K59_RS19505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C3K59_RS19510	COG1609	Transcriptional regulator
C3K59_RS19515	COG3180	Ammonia monooxygenase
C3K59_RS19520	COG2814	Major facilitator Superfamily
C3K59_RS19520	COG0477	Major facilitator Superfamily
C3K59_RS19525	COG4533	DNA binding
C3K59_RS19535	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C3K59_RS19540	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C3K59_RS19550	COG0420	3'-5' exonuclease activity
C3K59_RS19555	COG0419	ATPase involved in DNA repair
C3K59_RS19560	COG1403	HNH endonuclease
C3K59_RS19600	COG5337	Spore coat protein CotH
C3K59_RS19605	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3K59_RS19615	COG1404	Belongs to the peptidase S8 family
C3K59_RS19630	COG2318	DinB family
C3K59_RS19635	COG1562	ergosterol biosynthetic process
C3K59_RS19640	COG0534	Mate efflux family protein
C3K59_RS19645	COG1917	Cupin 2, conserved barrel domain protein
C3K59_RS19645	COG2207	Transcriptional regulator
C3K59_RS19650	COG1609	Transcriptional regulator
C3K59_RS19655	COG0673	inositol 2-dehydrogenase activity
C3K59_RS19660	COG2318	DinB family
C3K59_RS19665	COG1279	arginine transmembrane transporter activity
C3K59_RS19670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3K59_RS19675	COG1357	PFAM Pentapeptide repeats (8 copies)
C3K59_RS19680	COG2267	carboxylic ester hydrolase activity
C3K59_RS19685	COG0529	Catalyzes the synthesis of activated sulfate
C3K59_RS19690	COG2046	Belongs to the sulfate adenylyltransferase family
C3K59_RS19695	COG0175	sulfate reduction
C3K59_RS19700	COG2045	Belongs to the ComB family
C3K59_RS19705	COG1809	phosphosulfolactate synthase activity
C3K59_RS19710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3K59_RS19715	COG4948	Mandelate Racemase Muconate Lactonizing
C3K59_RS19720	COG2814	Major facilitator Superfamily
C3K59_RS19725	COG0454	-acetyltransferase
C3K59_RS19730	COG2153	protein acetylation
C3K59_RS19735	COG0646	methionine synthase
C3K59_RS19735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C3K59_RS19740	COG1666	GTP binding
C3K59_RS19745	COG2996	Protein conserved in bacteria
C3K59_RS19765	COG1695	Transcriptional regulator
C3K59_RS19780	COG3227	Zinc metalloprotease (Elastase)
C3K59_RS19785	COG1307	EDD domain protein, DegV family
C3K59_RS19790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3K59_RS19810	COG0561	phosphatase activity
C3K59_RS19815	COG1073	alpha beta
C3K59_RS19820	COG2151	metal-sulfur cluster biosynthetic enzyme
C3K59_RS19830	COG0277	FAD linked oxidase domain protein
C3K59_RS19835	COG2271	Major facilitator Superfamily
C3K59_RS19840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3K59_RS19845	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3K59_RS19855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3K59_RS19860	COG0505	Belongs to the CarA family
C3K59_RS19865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3K59_RS19870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3K59_RS19885	COG2267	carboxylic ester hydrolase activity
C3K59_RS19895	COG1744	ABC transporter substrate-binding protein PnrA-like
C3K59_RS19910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3K59_RS19915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3K59_RS19920	COG5504	Zn-dependent protease
C3K59_RS19925	COG0444	Belongs to the ABC transporter superfamily
C3K59_RS19930	COG4608	Belongs to the ABC transporter superfamily
C3K59_RS19940	COG0601	transmembrane transport
C3K59_RS19955	COG0180	Tryptophanyl-tRNA synthetase
C3K59_RS19960	COG4166	transmembrane transport
C3K59_RS19965	COG0601	transmembrane transport
C3K59_RS19970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3K59_RS19975	COG0444	Belongs to the ABC transporter superfamily
C3K59_RS19980	COG4608	Belongs to the ABC transporter superfamily
C3K59_RS19985	COG2814	Major facilitator Superfamily
C3K59_RS19990	COG0456	acetyltransferase
C3K59_RS19995	COG1393	Belongs to the ArsC family
C3K59_RS20000	COG0861	Integral membrane protein TerC family
C3K59_RS20010	COG4862	establishment of competence for transformation
C3K59_RS20020	COG4469	Competence protein
C3K59_RS20025	COG1164	Oligoendopeptidase f
C3K59_RS20040	COG2346	COG2346, Truncated hemoglobins
C3K59_RS20045	COG0741	lytic transglycosylase activity
C3K59_RS20050	COG4116	CYTH
C3K59_RS20060	COG2357	RelA SpoT domain protein
C3K59_RS20065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C3K59_RS20070	COG0564	pseudouridine synthase activity
C3K59_RS20075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C3K59_RS20080	COG0475	glutathione-regulated potassium exporter activity
C3K59_RS20080	COG0569	domain protein
C3K59_RS20085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C3K59_RS20095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3K59_RS20100	COG2104	thiamine diphosphate biosynthetic process
C3K59_RS20105	COG2022	thiamine diphosphate biosynthetic process
C3K59_RS20110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C3K59_RS20115	COG0351	phosphomethylpyrimidine kinase
C3K59_RS20120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C3K59_RS20175	COG0210	DNA helicase
C3K59_RS20185	COG2153	protein acetylation
C3K59_RS20190	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C3K59_RS20195	COG2382	esterase
C3K59_RS20200	COG0626	cystathionine gamma-synthase activity
C3K59_RS20205	COG0626	cystathionine gamma-synthase activity
C3K59_RS20210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K59_RS20215	COG5505	Protein of unknown function (DUF819)
C3K59_RS20235	COG5444	nuclease activity
C3K59_RS20285	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C3K59_RS20290	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS20300	COG3711	transcriptional antiterminator
C3K59_RS20300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K59_RS20310	COG1482	cell wall glycoprotein biosynthetic process
C3K59_RS20320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K59_RS20330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3K59_RS20345	COG0109	protoheme IX farnesyltransferase activity
C3K59_RS20355	COG0726	polysaccharide deacetylase
C3K59_RS20370	COG5504	Zn-dependent protease
C3K59_RS20375	COG2205	protein histidine kinase activity
C3K59_RS20385	COG3383	formate dehydrogenase (NAD+) activity
C3K59_RS20390	COG2427	Protein of unknown function (DUF1641)
C3K59_RS20400	COG1051	belongs to the nudix hydrolase family
C3K59_RS20410	COG2124	cytochrome p450
C3K59_RS20415	COG1819	glycosyl
C3K59_RS20425	COG1587	Uroporphyrinogen-III synthase
C3K59_RS20430	COG0390	transport system, permease component
C3K59_RS20435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3K59_RS20440	COG0697	spore germination
C3K59_RS20445	COG4297	protein containing double-stranded beta helix domain
C3K59_RS20455	COG1252	NADH dehydrogenase
C3K59_RS20460	COG1904	glucuronate isomerase
C3K59_RS20465	COG2211	Major facilitator Superfamily
C3K59_RS20475	COG1063	alcohol dehydrogenase
C3K59_RS20480	COG1312	Catalyzes the dehydration of D-mannonate
C3K59_RS20485	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS20495	COG1609	Transcriptional regulator
C3K59_RS20505	COG2721	sulfolactate sulfo-lyase activity
C3K59_RS20510	COG0730	response to heat
C3K59_RS20515	COG2318	DinB family
C3K59_RS20520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3K59_RS20525	COG0457	Tetratricopeptide repeat
C3K59_RS20535	COG2350	Protein conserved in bacteria
C3K59_RS20540	COG1388	LysM domain
C3K59_RS20540	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS20540	COG5632	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS20550	COG4195	phage-related replication protein
C3K59_RS20555	COG3546	catalase activity
C3K59_RS20560	COG2856	Zn peptidase
C3K59_RS20565	COG1396	sequence-specific DNA binding
C3K59_RS20575	COG1522	sequence-specific DNA binding
C3K59_RS20580	COG1484	DNA-dependent DNA replication
C3K59_RS20600	COG1595	DNA-templated transcription, initiation
C3K59_RS20605	COG3728	DNA packaging
C3K59_RS20605	COG5484	DNA packaging
C3K59_RS20610	COG1783	phage Terminase large subunit
C3K59_RS20615	COG5518	Phage portal protein
C3K59_RS20620	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C3K59_RS20625	COG4653	Phage capsid family
C3K59_RS20675	COG5412	phage tail tape measure protein
C3K59_RS20675	COG3953	SLT domain
C3K59_RS20675	COG5412	phage tail tape measure protein
C3K59_RS20675	COG3953	SLT domain
C3K59_RS20680	COG1652	LysM domain
C3K59_RS20685	COG4193	domain, Protein
C3K59_RS20695	COG3628	GPW Gp25 family protein
C3K59_RS20700	COG3299	homolog of phage Mu protein gp47
C3K59_RS20705	COG3778	Protein conserved in bacteria
C3K59_RS20745	COG3409	Peptidoglycan-binding domain 1 protein
C3K59_RS20745	COG5632	N-Acetylmuramoyl-L-alanine amidase
C3K59_RS20765	COG0306	phosphate transporter
C3K59_RS20770	COG1392	Phosphate transport regulator
C3K59_RS20775	COG0531	amino acid
C3K59_RS20780	COG0346	lactoylglutathione lyase activity
C3K59_RS20785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C3K59_RS20790	COG0463	Glycosyl transferase, family 2
C3K59_RS20800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3K59_RS20805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3K59_RS20810	COG2362	D-Aminopeptidase
C3K59_RS20815	COG0601	transmembrane transport
C3K59_RS20820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3K59_RS20825	COG0444	Belongs to the ABC transporter superfamily
C3K59_RS20830	COG4166	transmembrane transport
C3K59_RS20840	COG4948	Mandelate Racemase Muconate Lactonizing
C3K59_RS20850	COG4608	Belongs to the ABC transporter superfamily
C3K59_RS20855	COG2706	6-phosphogluconolactonase activity
C3K59_RS20860	COG1834	amidinotransferase
C3K59_RS20865	COG1607	acyl-coa hydrolase
C3K59_RS20870	COG1017	nitric oxide dioxygenase activity
C3K59_RS20870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C3K59_RS20880	COG2323	membrane
C3K59_RS20885	COG2318	DinB family
C3K59_RS20890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3K59_RS20895	COG2076	Multidrug Resistance protein
C3K59_RS20900	COG2076	Multidrug Resistance protein
C3K59_RS20905	COG0788	formyltetrahydrofolate deformylase activity
C3K59_RS20910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3K59_RS20915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3K59_RS20920	COG1764	response to oxidative stress
C3K59_RS20925	COG1846	Transcriptional regulator
C3K59_RS20930	COG1764	response to oxidative stress
C3K59_RS20940	COG0590	tRNA wobble adenosine to inosine editing
C3K59_RS20945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3K59_RS20950	COG1404	Belongs to the peptidase S8 family
C3K59_RS20955	COG1366	Belongs to the anti-sigma-factor antagonist family
C3K59_RS20960	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C3K59_RS20965	COG1122	ATPase activity
C3K59_RS20970	COG4721	ABC-type cobalt transport system, permease component
C3K59_RS20980	COG0745	RESPONSE REGULATOR receiver
C3K59_RS20985	COG3850	Histidine kinase
C3K59_RS20985	COG5002	protein histidine kinase activity
C3K59_RS20990	COG3212	peptidase
C3K59_RS20995	COG3212	peptidase
C3K59_RS21005	COG2239	Acts as a magnesium transporter
C3K59_RS21025	COG1846	Transcriptional regulator
C3K59_RS21030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3K59_RS21035	COG0726	polysaccharide deacetylase
C3K59_RS21040	COG1408	metallophosphoesterase
C3K59_RS21050	COG0463	Glycosyl transferase, family 2
C3K59_RS21055	COG3285	dna ligase
C3K59_RS21055	COG1793	dna ligase
C3K59_RS21060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C3K59_RS21065	COG3300	MHYT domain
C3K59_RS21065	COG5001	Diguanylate cyclase
C3K59_RS21070	COG0586	Pfam SNARE associated Golgi protein
C3K59_RS21075	COG0861	Integral membrane protein TerC family
C3K59_RS21080	COG1191	sigma factor activity
C3K59_RS21100	COG0501	Belongs to the peptidase M48B family
C3K59_RS21105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3K59_RS21120	COG3594	Acyltransferase
C3K59_RS21125	COG5002	protein histidine kinase activity
C3K59_RS21130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3K59_RS21140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C3K59_RS21145	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C3K59_RS21150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3K59_RS21155	COG0436	Aminotransferase
C3K59_RS21170	COG0235	Class ii aldolase
C3K59_RS21175	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C3K59_RS21180	COG3339	Conserved Protein
C3K59_RS21195	COG3852	Histidine kinase
C3K59_RS21200	COG1846	Transcriptional regulator
C3K59_RS21205	COG1360	Flagellar Motor Protein
C3K59_RS21210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C3K59_RS21215	COG0542	response to heat
C3K59_RS21220	COG3949	Membrane
C3K59_RS21225	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C3K59_RS21230	COG0720	synthase
C3K59_RS21235	COG0602	queuosine metabolic process
C3K59_RS21240	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C3K59_RS21245	COG1733	regulation of RNA biosynthetic process
C3K59_RS21250	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS21260	COG1388	LysM domain
C3K59_RS21265	COG3858	chitin binding
C3K59_RS21275	COG4873	Protein conserved in bacteria
C3K59_RS21285	COG3773	Cell wall hydrolase
C3K59_RS21290	COG2244	polysaccharide biosynthetic process
C3K59_RS21295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS21300	COG2217	Heavy metal translocating P-type atpase
C3K59_RS21310	COG0006	proline dipeptidase activity
C3K59_RS21315	COG1609	Transcriptional regulator
C3K59_RS21320	COG3711	transcriptional antiterminator
C3K59_RS21325	COG1263	PTS System
C3K59_RS21325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3K59_RS21325	COG2190	(PTS) system
C3K59_RS21330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3K59_RS21335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C3K59_RS21345	COG1533	DNA photolyase activity
C3K59_RS21350	COG0456	acetyltransferase
C3K59_RS21355	COG0840	transmembrane signaling receptor activity
C3K59_RS21360	COG2084	Dehydrogenase
C3K59_RS21365	COG2340	Cysteine-rich secretory protein family
C3K59_RS21370	COG0768	penicillin binding
C3K59_RS21375	COG4191	Histidine kinase
C3K59_RS21380	COG0436	Aminotransferase
C3K59_RS21390	COG0835	chemotaxis
C3K59_RS21390	COG0784	Response regulator, receiver
C3K59_RS21400	COG2814	Major facilitator Superfamily
C3K59_RS21405	COG1376	ErfK ybiS ycfS ynhG family protein
C3K59_RS21410	COG1408	metallophosphoesterase
C3K59_RS21415	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS21420	COG2200	EAL domain
C3K59_RS21425	COG4703	Protein of unknown function (DUF1797)
C3K59_RS21440	COG0517	IMP dehydrogenase activity
C3K59_RS21445	COG0583	DNA-binding transcription factor activity
C3K59_RS21450	COG0716	FMN binding
C3K59_RS21460	COG0716	FMN binding
C3K59_RS21465	COG2171	N-acyltransferase activity
C3K59_RS21470	COG1473	amidohydrolase
C3K59_RS21480	COG0668	transmembrane transport
C3K59_RS21485	COG0450	alkyl hydroperoxide reductase
C3K59_RS21490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS21505	COG0746	molybdenum cofactor guanylyltransferase activity
C3K59_RS21515	COG0303	'Molybdopterin
C3K59_RS21520	COG1763	Mo-molybdopterin cofactor biosynthetic process
C3K59_RS21525	COG0314	molybdopterin synthase activity
C3K59_RS21530	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C3K59_RS21535	COG1132	(ABC) transporter
C3K59_RS21540	COG1132	(ABC) transporter
C3K59_RS21550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3K59_RS21555	COG1136	(ABC) transporter
C3K59_RS21560	COG0577	efflux transmembrane transporter activity
C3K59_RS21580	COG0681	Belongs to the peptidase S26 family
C3K59_RS21590	COG0488	(ABC) transporter
C3K59_RS21595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C3K59_RS21600	COG2309	aminopeptidase activity
C3K59_RS21610	COG1077	Cell shape determining protein MreB Mrl
C3K59_RS21615	COG2002	toxin-antitoxin pair type II binding
C3K59_RS21620	COG3852	Histidine kinase
C3K59_RS21625	COG2105	PFAM AIG2 family protein
C3K59_RS21625	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C3K59_RS21630	COG0569	domain protein
C3K59_RS21635	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C3K59_RS21640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3K59_RS21650	COG0561	phosphatase activity
C3K59_RS21655	COG0242	peptide deformylase activity
C3K59_RS21665	COG0497	DNA recombination
C3K59_RS21670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3K59_RS21675	COG0022	dehydrogenase e1 component
C3K59_RS21680	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3K59_RS21685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3K59_RS21690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3K59_RS21700	COG1982	Orn Lys Arg decarboxylase major
C3K59_RS21705	COG4476	Belongs to the UPF0223 family
C3K59_RS21710	COG4493	Belongs to the UPF0637 family
C3K59_RS21720	COG0483	inositol monophosphate 1-phosphatase activity
C3K59_RS21730	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C3K59_RS21750	COG1595	DNA-templated transcription, initiation
C3K59_RS21780	COG4896	Protein conserved in bacteria
C3K59_RS21790	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3K59_RS21795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3K59_RS21800	COG2066	Belongs to the glutaminase family
C3K59_RS21805	COG4838	Belongs to the UPF0358 family
C3K59_RS21810	COG0772	Belongs to the SEDS family
C3K59_RS21815	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C3K59_RS21820	COG1612	heme a metabolic process
C3K59_RS21825	COG0109	protoheme IX farnesyltransferase activity
C3K59_RS21830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3K59_RS21830	COG2010	Cytochrome c
C3K59_RS21835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3K59_RS21840	COG1845	cytochrome c oxidase, subunit III
C3K59_RS21845	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C3K59_RS21850	COG3336	cytochrome c oxidase
C3K59_RS21860	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C3K59_RS21865	COG2340	Cysteine-rich secretory protein family
C3K59_RS21880	COG3679	Belongs to the UPF0342 family
C3K59_RS21885	COG4471	UPF0298 protein
C3K59_RS21895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C3K59_RS21900	COG3314	Sporulation integral membrane protein YlbJ
C3K59_RS21905	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3K59_RS21910	COG3480	Lon protease (S16) C-terminal proteolytic domain
C3K59_RS21925	COG1399	metal-binding, possibly nucleic acid-binding protein
C3K59_RS21940	COG0454	-acetyltransferase
C3K59_RS21945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C3K59_RS21950	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C3K59_RS21955	COG2001	Belongs to the MraZ family
C3K59_RS21960	COG0275	rRNA processing
C3K59_RS21965	COG4839	cell division protein FtsL
C3K59_RS21975	COG0768	penicillin binding
C3K59_RS21980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C3K59_RS21985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3K59_RS21990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3K59_RS21995	COG0772	Belongs to the SEDS family
C3K59_RS22000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3K59_RS22005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C3K59_RS22010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C3K59_RS22015	COG3879	Bacterial protein of unknown function (DUF881)
C3K59_RS22020	COG3879	Bacterial protein of unknown function (DUF881)
C3K59_RS22025	COG3856	small basic protein
C3K59_RS22030	COG0849	cell division
C3K59_RS22035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3K59_RS22040	COG1404	Belongs to the peptidase S8 family
C3K59_RS22040	COG4412	M6 family metalloprotease domain protein
C3K59_RS22050	COG1191	sigma factor activity
C3K59_RS22055	COG1191	sigma factor activity
C3K59_RS22060	COG1119	ATPase activity
C3K59_RS22065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3K59_RS22070	COG1873	PFAM PRC-barrel domain
C3K59_RS22080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C3K59_RS22085	COG1799	cell septum assembly
C3K59_RS22090	COG0762	integral membrane protein
C3K59_RS22100	COG3599	regulation of cell shape
C3K59_RS22105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C3K59_RS22110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3K59_RS22115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3K59_RS22120	COG0564	pseudouridine synthase activity
C3K59_RS22125	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C3K59_RS22130	COG2233	PERMEase
C3K59_RS22135	COG0540	Belongs to the ATCase OTCase family
C3K59_RS22140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3K59_RS22145	COG0505	Belongs to the CarA family
C3K59_RS22150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3K59_RS22155	COG0543	2 iron, 2 sulfur cluster binding
C3K59_RS22165	COG0284	orotidine-5'-phosphate decarboxylase activity
C3K59_RS22170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3K59_RS22175	COG0175	sulfate reduction
C3K59_RS22180	COG0306	phosphate transporter
C3K59_RS22185	COG2046	Belongs to the sulfate adenylyltransferase family
C3K59_RS22190	COG0529	Catalyzes the synthesis of activated sulfate
C3K59_RS22200	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C3K59_RS22205	COG1648	precorrin-2 dehydrogenase activity
C3K59_RS22210	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C3K59_RS22215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3K59_RS22220	COG1561	YicC-like family, N-terminal region
C3K59_RS22230	COG0194	GDP metabolic process
C3K59_RS22235	COG1758	RNA polymerase activity
C3K59_RS22240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3K59_RS22245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3K59_RS22250	COG0242	peptide deformylase activity
C3K59_RS22255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3K59_RS22260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3K59_RS22260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C3K59_RS22265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3K59_RS22270	COG0631	protein serine/threonine phosphatase activity
C3K59_RS22275	COG0515	serine threonine protein kinase
C3K59_RS22275	COG2815	serine threonine protein kinase
C3K59_RS22280	COG1162	GTPase activity
C3K59_RS22285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3K59_RS22290	COG1564	THIamine pyrophosphokinase
C3K59_RS22300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3K59_RS22305	COG1302	Protein conserved in bacteria
C3K59_RS22310	COG1461	Dihydroxyacetone kinase
C3K59_RS22315	COG1760	l-serine dehydratase
C3K59_RS22320	COG1760	l-serine dehydratase
C3K59_RS22325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3K59_RS22330	COG2050	protein possibly involved in aromatic compounds catabolism
C3K59_RS22330	COG1349	DNA-binding transcription factor activity
C3K59_RS22335	COG0416	fatty acid biosynthetic process
C3K59_RS22340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C3K59_RS22345	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS22355	COG0571	ribonuclease III activity
C3K59_RS22360	COG1196	nuclear chromosome segregation
C3K59_RS22365	COG0552	protein localization to endoplasmic reticulum
C3K59_RS22375	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C3K59_RS22380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3K59_RS22385	COG0228	four-way junction DNA binding
C3K59_RS22390	COG1837	Belongs to the UPF0109 family
C3K59_RS22400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3K59_RS22405	COG0336	Belongs to the RNA methyltransferase TrmD family
C3K59_RS22410	COG0335	large ribosomal subunit rRNA binding
C3K59_RS22415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C3K59_RS22420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C3K59_RS22430	COG2257	FlhB HrpN YscU SpaS Family
C3K59_RS22440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C3K59_RS22450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3K59_RS22455	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C3K59_RS22460	COG4974	Belongs to the 'phage' integrase family
C3K59_RS22465	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C3K59_RS22470	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C3K59_RS22475	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C3K59_RS22480	COG1815	bacterial-type flagellum-dependent cell motility
C3K59_RS22485	COG1558	bacterial-type flagellum-dependent cell motility
C3K59_RS22490	COG1677	Flagellar hook-basal body complex protein FliE
C3K59_RS22495	COG1766	The M ring may be actively involved in energy transduction
C3K59_RS22500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3K59_RS22505	COG1317	bacterial-type flagellum organization
C3K59_RS22510	COG1157	protein secretion by the type III secretion system
C3K59_RS22515	COG2882	bacterial-type flagellum organization
C3K59_RS22525	COG3144	bacterial-type flagellum assembly
C3K59_RS22530	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C3K59_RS22535	COG4786	Flagellar basal body rod
C3K59_RS22540	COG1582	Flagellar protein (FlbD)
C3K59_RS22545	COG1580	Controls the rotational direction of flagella during chemotaxis
C3K59_RS22550	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3K59_RS22555	COG1776	CheC inhibitor of MCP methylation
C3K59_RS22555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3K59_RS22560	COG2201	protein-glutamate methylesterase activity
C3K59_RS22565	COG3190	flagellar
C3K59_RS22570	COG1338	Plays a role in the flagellum-specific transport system
C3K59_RS22575	COG1987	bacterial-type flagellum assembly
C3K59_RS22580	COG1684	flagellar biosynthetic protein fliR
C3K59_RS22585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3K59_RS22590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3K59_RS22595	COG1419	protein localization to endoplasmic reticulum
C3K59_RS22600	COG0455	bacterial-type flagellum organization
C3K59_RS22605	COG2201	protein-glutamate methylesterase activity
C3K59_RS22610	COG2198	Histidine kinase
C3K59_RS22610	COG0643	Histidine kinase
C3K59_RS22615	COG0835	chemotaxis
C3K59_RS22620	COG1776	CheC inhibitor of MCP methylation
C3K59_RS22625	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C3K59_RS22630	COG1191	sigma factor activity
C3K59_RS22640	COG0052	Belongs to the universal ribosomal protein uS2 family
C3K59_RS22645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3K59_RS22650	COG0528	UMP kinase activity
C3K59_RS22655	COG0233	cytoplasmic translational termination
C3K59_RS22660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3K59_RS22665	COG4589	Belongs to the CDS family
C3K59_RS22670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C3K59_RS22675	COG0750	zinc metalloprotease
C3K59_RS22680	COG0442	prolyl-tRNA aminoacylation
C3K59_RS22685	COG2176	DNA-directed DNA polymerase activity
C3K59_RS22690	COG0779	Required for maturation of 30S ribosomal subunits
C3K59_RS22695	COG0195	Participates in both transcription termination and antitermination
C3K59_RS22700	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C3K59_RS22705	COG1358	cellular component organization or biogenesis
C3K59_RS22710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C3K59_RS22715	COG1550	Protein conserved in bacteria
C3K59_RS22720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3K59_RS22725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3K59_RS22730	COG0196	riboflavin kinase activity
C3K59_RS22735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3K59_RS22740	COG1185	polyribonucleotide nucleotidyltransferase activity
C3K59_RS22745	COG0726	polysaccharide deacetylase
C3K59_RS22750	COG0612	Peptidase, M16
C3K59_RS22755	COG1873	PFAM PRC-barrel domain
C3K59_RS22760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3K59_RS22765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3K59_RS22770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C3K59_RS22775	COG0527	aspartate kinase activity
C3K59_RS22780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C3K59_RS22785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3K59_RS22790	COG0740	serine-type endopeptidase activity
C3K59_RS22800	COG1674	ftsk spoiiie
C3K59_RS22800	COG4980	gas vesicle protein
C3K59_RS22805	COG2188	Transcriptional regulator
C3K59_RS22810	COG2814	Major facilitator Superfamily
C3K59_RS22815	COG0612	Peptidase, M16
C3K59_RS22820	COG0612	Peptidase, M16
C3K59_RS22825	COG0300	oxidoreductase activity
C3K59_RS22840	COG1426	Protein conserved in bacteria
C3K59_RS22845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3K59_RS22850	COG1546	Belongs to the CinA family
C3K59_RS22850	COG1058	Belongs to the CinA family
C3K59_RS22855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C3K59_RS22860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C3K59_RS22865	COG1418	mRNA catabolic process
C3K59_RS22870	COG1692	metallophosphoesterase
C3K59_RS22875	COG2359	stage V sporulation protein S
C3K59_RS22880	COG1063	alcohol dehydrogenase
C3K59_RS22885	COG0156	8-amino-7-oxononanoate synthase activity
C3K59_RS22890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3K59_RS22895	COG4550	Control of competence regulator ComK, YlbF/YmcA
C3K59_RS22905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3K59_RS22910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C3K59_RS22925	COG3226	Transcriptional regulator
C3K59_RS22930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3K59_RS22940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C3K59_RS22945	COG3321	synthase
C3K59_RS22950	COG2070	2-Nitropropane dioxygenase
C3K59_RS22950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C3K59_RS22955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3K59_RS22960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3K59_RS22965	COG3425	synthase
C3K59_RS22970	COG1024	Enoyl-CoA hydratase
C3K59_RS22975	COG1024	Enoyl-CoA hydratase
C3K59_RS22990	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS22990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C3K59_RS22990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3K59_RS22990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3K59_RS22990	COG3321	synthase
C3K59_RS22995	COG4221	oxidoreductase activity
C3K59_RS22995	COG3321	synthase
C3K59_RS22995	COG1028	Short-chain dehydrogenase reductase Sdr
C3K59_RS22995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity