locus-tag class description HR084_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HR084_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HR084_RS00015 ENOG410848D S4 domain protein YaaA HR084_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HR084_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HR084_RS00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HR084_RS00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HR084_RS00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HR084_RS00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HR084_RS00100 ENOG4105ZMH deoxynucleoside kinase HR084_RS00110 ENOG4105VRS hydrolase family 18 HR084_RS00115 ENOG4105GTG Isochorismatase HR084_RS00120 ENOG4108Z6B deaminase HR084_RS00130 ENOG4105C6E dna polymerase iii HR084_RS00135 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HR084_RS00140 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HR084_RS00150 ENOG41067KS pro-sigma K processing HR084_RS00190 ENOG4105CDW Resistance protein HR084_RS00195 ENOG4105CXN decarboxylase HR084_RS00200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HR084_RS00205 ENOG4105X0R protein from nitrogen regulatory protein P-II HR084_RS00210 ENOG4105XVJ Protein of unknown function (DUF327) HR084_RS00215 ENOG4105FA2 dna polymerase iii HR084_RS00220 ENOG4105MA4 psp1 domain protein HR084_RS00225 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) HR084_RS00230 ENOG41060K3 Methyltransferase HR084_RS00235 ENOG4105VC4 domain protein HR084_RS00240 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HR084_RS00245 ENOG4105KRN Transcriptional regulator, abrb family HR084_RS00250 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HR084_RS00255 ENOG4105F8V Hydrolase, tatD family HR084_RS00260 ENOG41069ER domain protein HR084_RS00270 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HR084_RS00275 ENOG4105XFA sporulation peptidase YabG HR084_RS00280 ENOG4105W42 Veg protein HR084_RS00285 ENOG4105XEW small acid-soluble spore protein HR084_RS00290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HR084_RS00295 ENOG4105DFT pur operon repressor HR084_RS00300 ENOG4105KME endoribonuclease L-psp HR084_RS00305 ENOG4105K4W Could be involved in septation (By similarity) HR084_RS00310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HR084_RS00315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HR084_RS00320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HR084_RS00325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HR084_RS00335 ENOG4108JA2 transcriptioN-repair coupling factor HR084_RS00340 ENOG4108M14 stage v sporulation protein t HR084_RS00350 ENOG4108IY2 MazG family HR084_RS00355 ENOG41082I2 s4 domain protein HR084_RS00360 ENOG4105VYY sporulation protein yabp HR084_RS00375 ENOG41060GV RNA binding s1 domain protein HR084_RS00405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HR084_RS00410 ENOG4108UGV hypoxanthine phosphoribosyltransferase HR084_RS00415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HR084_RS00425 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HR084_RS00430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HR084_RS00435 ENOG4105C6T cysteine synthase HR084_RS00440 ENOG4105CRQ synthase (Component I) HR084_RS00445 ENOG4105DDQ anthranilate synthase HR084_RS00450 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HR084_RS00455 ENOG4105EEI dihydropteroate synthase HR084_RS00460 ENOG4105KRF dihydroneopterin aldolase HR084_RS00465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HR084_RS00475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HR084_RS00480 ENOG4105CRK lysyL-tRNA synthetase HR084_RS00565 ENOG4108Z0C Uvrb UvrC protein HR084_RS00570 ENOG41066A3 ATP guanido phosphotransferase HR084_RS00580 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HR084_RS00585 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HR084_RS00590 ENOG4105CTP PilT protein domain protein HR084_RS00595 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HR084_RS00600 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HR084_RS00605 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HR084_RS00610 ENOG4105D7W serine acetyltransferase HR084_RS00615 ENOG4105C8N cysteinyl-tRNA synthetase HR084_RS00620 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HR084_RS00625 ENOG4105C2N RNA methyltransferase TrmH family group 3 HR084_RS00630 ENOG4105M0M Tetracycline resistance protein HR084_RS00650 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HR084_RS00665 ENOG4108VZM 50s ribosomal protein L10 HR084_RS00675 ENOG4107Y49 methyltransferase HR084_RS00680 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HR084_RS00685 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HR084_RS00690 ENOG4105XPM ribosomal protein HR084_RS00695 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HR084_RS00700 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HR084_RS00705 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HR084_RS00710 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HR084_RS00715 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HR084_RS00720 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HR084_RS00725 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HR084_RS00730 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HR084_RS00740 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HR084_RS00755 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HR084_RS00760 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HR084_RS00770 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HR084_RS00775 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HR084_RS00785 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HR084_RS00795 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HR084_RS00800 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HR084_RS00805 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HR084_RS00810 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HR084_RS00820 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HR084_RS00825 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HR084_RS00835 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HR084_RS00850 ENOG41067V7 50S ribosomal protein L36 HR084_RS00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HR084_RS00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HR084_RS00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HR084_RS00870 ENOG4108ZT0 50S ribosomal protein l17 HR084_RS00875 ENOG4108JJB ABC transporter HR084_RS00880 ENOG4108JJB ABC transporter HR084_RS00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HR084_RS00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HR084_RS00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HR084_RS00900 ENOG4108UJD 30S ribosomal protein S9 HR084_RS00905 ENOG4108I0C methyltransferase HR084_RS00920 ENOG4105D1F ATP-binding protein HR084_RS00935 ENOG4108NMV polysaccharide deacetylase HR084_RS01090 ENOG4105CHH sulfate transporter HR084_RS01100 ENOG4108SA1 esterase HR084_RS01120 ENOG410874W AraC family transcriptional regulator HR084_RS01125 ENOG4105EHZ conserved protein UCP016719 HR084_RS01130 ENOG4105D17 glycoside hydrolase, family 3 domain protein HR084_RS01150 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HR084_RS01160 ENOG4105EWC Purine nucleoside phosphorylase HR084_RS01190 ENOG4105EMN RNA polymerase sigma factor HR084_RS01200 ENOG4105C8B TIGR00159 family HR084_RS01205 ENOG4107U5W ybbr family HR084_RS01210 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HR084_RS01215 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HR084_RS01225 ENOG4105D03 DNA-3-methyladenine glycosylase II HR084_RS01235 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HR084_RS01240 ENOG4108TWJ NADH dehydrogenase subunit 5 HR084_RS01260 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HR084_RS01265 ENOG4105WAB arsR family transcriptional regulator HR084_RS01270 ENOG4108RWP Major Facilitator Superfamily protein HR084_RS01305 ENOG4105G0J serine threonine protein kinase HR084_RS01315 ENOG4106K80 HR084_RS01325 ENOG4106DDH Sporulation-specific SASP protein HR084_RS01335 ENOG4108HWY Beta-lactamase HR084_RS01340 ENOG4107E6A Cytochrome p-450 HR084_RS01350 ENOG4107QTZ amino acid HR084_RS01355 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HR084_RS01360 ENOG4105CXY transporter HR084_RS01370 ENOG410645S MarR family Transcriptional regulator HR084_RS01375 ENOG4105DCM major facilitator superfamily HR084_RS01390 ENOG410631K Membrane HR084_RS01395 ENOG4106AXJ AraC family transcriptional regulator HR084_RS01400 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HR084_RS01405 ENOG4108TCS Glutamyl endopeptidase HR084_RS01415 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HR084_RS01420 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HR084_RS01425 ENOG4107ZTW SNARE associated Golgi HR084_RS01445 ENOG4105C72 UPF0176 protein HR084_RS01455 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane HR084_RS01460 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HR084_RS01475 ENOG4105CM2 brancheD-chain amino acid aminotransferase HR084_RS01480 ENOG4108IQI permease HR084_RS01485 ENOG4108J5H Homocysteine s-methyltransferase HR084_RS01495 ENOG4105CSV Glutaminase HR084_RS01510 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HR084_RS01515 ENOG4105C26 Dehydrogenase HR084_RS01520 ENOG4105DJB Major Facilitator Superfamily HR084_RS01525 ENOG4105EQX glucarate dehydratase HR084_RS01530 ENOG41073TP transcriptional regulator HR084_RS01535 ENOG4105CTX dehydratase HR084_RS01550 ENOG4106UX7 integral membrane protein HR084_RS01555 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HR084_RS01590 ENOG4105MUA Resistance protein HR084_RS01600 ENOG4105DGI Alkaline phosphatase HR084_RS01605 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HR084_RS01610 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HR084_RS01615 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HR084_RS01620 ENOG4107EPV Aminotransferase class V HR084_RS01625 ENOG4105C0R drug resistance transporter emrb qaca subfamily HR084_RS01630 ENOG4105J7D transcriptional regulator HR084_RS01635 ENOG4107RB3 L-asparaginase HR084_RS01640 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HR084_RS01650 ENOG41060AI SEC-C motif HR084_RS01660 ENOG4107Y7X LytTR HR084_RS01665 ENOG4108IUW ABC transporter HR084_RS01670 ENOG4108SDH ABC, transporter HR084_RS01675 ENOG4107SET aldo keto reductase HR084_RS01710 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HR084_RS01720 ENOG4105DSE periplasmic solute binding protein HR084_RS01725 ENOG4105DIK (ABC) transporter HR084_RS01735 ENOG4105DEN Luciferase family HR084_RS01740 ENOG4108N0M stress protein HR084_RS01745 ENOG4106FN3 tellurium resistance protein HR084_RS01750 ENOG4106FN3 tellurium resistance protein HR084_RS01755 ENOG4107TS3 membrane protein, TerC HR084_RS01760 ENOG4108TTB tellurium resistance protein HR084_RS01770 ENOG41079KZ Major Facilitator Superfamily HR084_RS01775 ENOG4107XZQ multidrug resistance protein HR084_RS01780 ENOG4108A65 Transcriptional regulator HR084_RS01785 ENOG4108IJ7 Glycine betaine HR084_RS01790 ENOG4107SQ8 Glycine betaine HR084_RS01820 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HR084_RS01855 ENOG4105EIG urea carboxylase-associated protein 1 HR084_RS01860 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HR084_RS01865 ENOG4105I1F Resistance protein HR084_RS01870 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HR084_RS01875 ENOG41089UC methyltransferase, type 11 HR084_RS01880 ENOG4105C5Q Transcriptional regulator HR084_RS01885 ENOG4105I82 acetyl xylan esterase HR084_RS01890 ENOG410756H nucleotidyltransferase HR084_RS01900 ENOG4105C26 Dehydrogenase HR084_RS01905 ENOG4105CK7 Sodium proline symporter HR084_RS01910 ENOG4107YHD transcriptional regulator HR084_RS01920 ENOG4108PJD permease HR084_RS01925 ENOG4105U6C Alpha beta hydrolase fold protein HR084_RS01935 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HR084_RS01940 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HR084_RS01945 ENOG4108IFG nitrite reductase, (NAD(P)H) HR084_RS01950 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HR084_RS01970 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HR084_RS01985 ENOG4105CKI cobalamin synthesis protein HR084_RS01990 ENOG4105E5Q amino acid AbC transporter HR084_RS01995 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein HR084_RS02005 ENOG4105HHM rdd domain containing protein HR084_RS02015 ENOG4105CS2 ec 3.2.1.21 HR084_RS02030 ENOG4105C8Q Methyl-accepting chemotaxis HR084_RS02035 ENOG41080HJ 6-phospho 3-hexuloisomerase HR084_RS02040 ENOG4108VA3 3-hexulose-6-phosphate synthase HR084_RS02045 ENOG4105KVH Transcriptional regulator HR084_RS02050 ENOG4105CEY Amp-dependent synthetase and ligase HR084_RS02080 ENOG4105SX7 Transporter HR084_RS02090 ENOG4105W8Z 4'-phosphopantetheinyl transferase HR084_RS02100 ENOG4105CDA abc transporter atp-binding protein HR084_RS02105 ENOG4105DRP amino acid AbC transporter HR084_RS02115 ENOG4106P55 Transcriptional regulator HR084_RS02120 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HR084_RS02125 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HR084_RS02130 ENOG41069ZX HR084_RS02135 ENOG41069ZX HR084_RS02145 ENOG4105DUX Transporter HR084_RS02160 ENOG4105E1K spore germination protein HR084_RS02180 ENOG4107WD8 ABC transporter, permease HR084_RS02185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HR084_RS02190 ENOG4105BZU Histidine kinase HR084_RS02215 ENOG4105CFH Aspartokinase HR084_RS02220 ENOG4105DHS permease protein HR084_RS02225 ENOG4105CM4 permease protein HR084_RS02230 ENOG4108IPW abc transporter atp-binding protein HR084_RS02245 ENOG4105R8C Transcriptional regulator HR084_RS02250 ENOG4108DBC nitroreductase HR084_RS02255 ENOG41067V3 Antibiotic biosynthesis monooxygenase HR084_RS02260 ENOG4105YVS arsR family transcriptional regulator HR084_RS02270 ENOG4108JPW Aminotransferase HR084_RS02275 ENOG4105C26 Dehydrogenase HR084_RS02285 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HR084_RS02290 ENOG4105KTB nuclear export factor GLE1 HR084_RS02295 ENOG4108T5E Copper resistance protein HR084_RS02300 ENOG4108ZYE Transcriptional regulator HR084_RS02325 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HR084_RS02330 ENOG4108ZX0 Signal peptidase I HR084_RS02355 ENOG4105E7W lamb ycsf family protein HR084_RS02360 ENOG4105C5A transporter HR084_RS02365 ENOG4105CFM UPF0317 protein HR084_RS02370 ENOG4105P4J Allophanate hydrolase, subunit 1 HR084_RS02380 ENOG4107258 Transcriptional regulator HR084_RS02385 ENOG4105XJB lipolytic protein G-D-S-L family HR084_RS02395 ENOG41061CK Antibiotic biosynthesis monooxygenase HR084_RS02400 ENOG4107RVG penicillin-binding protein HR084_RS02405 ENOG4107QM2 Aldo Keto reductase HR084_RS02410 ENOG4105ETD TRANSCRIPTIONal HR084_RS02420 ENOG4105HMZ Methyltransferase HR084_RS02425 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HR084_RS02440 ENOG410606W general stress protein HR084_RS02450 ENOG4105VCH membrane HR084_RS02460 ENOG4105C9U ATP-dependent DNA helicase RecQ HR084_RS02475 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HR084_RS02480 ENOG4107R8N Glycosyl transferase, family 2 HR084_RS02490 ENOG4105C0X amino acid HR084_RS02525 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HR084_RS02535 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HR084_RS02540 ENOG4105EU9 HR084_RS02545 ENOG4105QVS general stress protein HR084_RS02550 ENOG41082W1 Cupin 2, conserved barrel domain protein HR084_RS02565 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HR084_RS02570 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HR084_RS02575 ENOG4108MRH transcriptional regulatory protein HR084_RS02580 ENOG4107QJT sodium dicarboxylate symporter HR084_RS02585 ENOG4106F5Q Membrane HR084_RS02595 ENOG4105CJ1 ABC, transporter HR084_RS02610 ENOG4105FDT acyl-CoA dehydrogenase HR084_RS02630 ENOG4105SZ6 Thioredoxin HR084_RS02635 ENOG4105CPF Cell wall formation (By similarity) HR084_RS02640 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HR084_RS02645 ENOG4105C1J atp-dependent rna helicase HR084_RS02650 ENOG410905X membrane-flanked domain protein HR084_RS02655 ENOG4105CKV Membrane HR084_RS02665 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HR084_RS02670 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HR084_RS02675 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HR084_RS02685 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HR084_RS02690 ENOG4107MMM Anti-sigma-factor antagonist HR084_RS02695 ENOG4105FUA antagonist HR084_RS02700 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HR084_RS02705 ENOG4107SGM protein serine threonine phosphatase HR084_RS02710 ENOG4105WN5 stage II sporulation protein HR084_RS02715 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HR084_RS02725 ENOG41064BQ Phosphatase HR084_RS02740 ENOG4105M5P UPF0310 protein HR084_RS02745 ENOG4105RV9 Transcriptional regulator HR084_RS02815 ENOG4106BHF HR084_RS02820 ENOG4105VZ8 Transcriptional regulator HR084_RS02830 ENOG4105ECK Fatty Acid Desaturase HR084_RS02835 ENOG4105VEQ Cold shock protein HR084_RS02850 ENOG4108MCI Transcriptional regulator, ARAC family HR084_RS02855 ENOG4108UZ3 Transporter HR084_RS02860 ENOG41086D8 Transcriptional regulator HR084_RS02865 ENOG4107U9B transcriptional regulator HR084_RS02870 ENOG4105DXI Major Facilitator superfamily HR084_RS02880 ENOG4105CZ9 Domain of unknown function (DU1801) HR084_RS02885 ENOG4105GIG HR084_RS02890 ENOG4105KRI phosphocarrier protein (HPr HR084_RS02895 ENOG4105ST3 Transcriptional regulator HR084_RS02900 ENOG4105T38 integral membrane protein HR084_RS02905 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HR084_RS02910 ENOG4108ZMQ domain protein HR084_RS02915 ENOG4105MJ9 esterase HR084_RS02920 ENOG4107Z6X Transcriptional regulator HR084_RS02930 ENOG4105KVH Transcriptional regulator HR084_RS02935 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HR084_RS02940 ENOG4105EQ0 Major Facilitator superfamily HR084_RS02945 ENOG4108JGH Tetr family transcriptional regulator HR084_RS02950 ENOG41082YX Transcriptional regulator, arsr family HR084_RS02955 ENOG4107R5R arsenical pump membrane protein HR084_RS02965 ENOG4105Z7P Acetyltransferase (GNAT) family HR084_RS02970 ENOG4107Y9U Membrane HR084_RS02980 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HR084_RS02985 ENOG4108ZHR arsR family transcriptional regulator HR084_RS02990 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HR084_RS03005 ENOG4105ENE Histidine kinase HR084_RS03010 ENOG4108VB1 regulatoR HR084_RS03015 ENOG4105EYF MMPL domain protein HR084_RS03020 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HR084_RS03025 ENOG4108UQV Membrane HR084_RS03030 ENOG4108Z5V transcriptional regulator, merr family HR084_RS03035 ENOG41076HS cation diffusion facilitator family transporter HR084_RS03040 ENOG4108TVJ Nitroreductase HR084_RS03045 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HR084_RS03050 ENOG4108VGI doxx family HR084_RS03055 ENOG4105XXY Thioredoxin HR084_RS03070 ENOG410900G Protein of unknown function (DUF421) HR084_RS03075 ENOG4108QY0 Membrane HR084_RS03095 ENOG4105PF9 Transcriptional regulator HR084_RS03105 ENOG4105WQG acetyltransferase HR084_RS03115 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HR084_RS03120 ENOG4105ETE Transcriptional regulator (LacI family HR084_RS03125 ENOG4105C54 Major Facilitator superfamily HR084_RS03140 ENOG4105C85 amino acid HR084_RS03150 ENOG41062A4 Transcriptional regulator HR084_RS03155 ENOG4105EYF MMPL domain protein HR084_RS03160 ENOG4108TVJ Nitroreductase HR084_RS03165 ENOG4105FS7 Transcriptional regulator HR084_RS03170 ENOG4105C2C drug resistance transporter, Bcr CflA HR084_RS03180 ENOG4105DRR Transcriptional regulator, GntR family HR084_RS03185 ENOG4105VRS hydrolase family 18 HR084_RS03200 ENOG4105G6Z alkaline phosphatase HR084_RS03205 ENOG4108ZMX Domain of unknown function (DU1801) HR084_RS03215 ENOG4108YM7 Gcn5-related n-acetyltransferase HR084_RS03220 ENOG4107TVP HD domain protein HR084_RS03225 ENOG41090UD (LipO)protein HR084_RS03230 ENOG4105F27 Major Facilitator HR084_RS03235 ENOG4105VZJ PTS System HR084_RS03240 ENOG4105VCP PTS System HR084_RS03245 ENOG4105CK1 PTS System HR084_RS03250 ENOG4105CS2 ec 3.2.1.21 HR084_RS03255 ENOG4108TZY GntR Family Transcriptional Regulator HR084_RS03260 ENOG4105EVU fructokinase HR084_RS03265 ENOG4105DG6 mannose-6-phosphate isomerase HR084_RS03270 ENOG4105D3P Mannan endo-1,4-beta-mannosidase HR084_RS03315 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HR084_RS03320 ENOG4105K8N protein family UPF0079, ATPase HR084_RS03325 ENOG41072GX Peptidase M22 Glycoprotease HR084_RS03330 ENOG410801F ribosomal-protein-alanine acetyltransferase HR084_RS03335 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HR084_RS03340 ENOG4105C5H ABC transporter HR084_RS03345 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HR084_RS03350 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HR084_RS03355 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HR084_RS03360 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HR084_RS03370 ENOG4108TYN CAAX amino terminal protease family protein HR084_RS03380 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HR084_RS03390 ENOG4105PGZ NB-ARC domain HR084_RS03395 ENOG4105CPQ Dehydrogenase HR084_RS03400 ENOG4105CT4 transporter HR084_RS03410 ENOG41087YS Phage shock protein A HR084_RS03415 ENOG4105DQX Zinc finger domain HR084_RS03420 ENOG4108WV1 Pfam:DUF477 HR084_RS03430 ENOG4108ZMR Ion transport 2 domain-containing protein HR084_RS03435 ENOG4107QNK )-transporter HR084_RS03465 ENOG4107YUH hydrolase HR084_RS03475 ENOG4107STQ Multicopper oxidase HR084_RS03480 ENOG4105C85 amino acid HR084_RS03495 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HR084_RS03525 ENOG4105C7N Xanthine uracil vitamin C permease HR084_RS03550 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HR084_RS03555 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HR084_RS03560 ENOG4105C83 adenylosuccinate lyase HR084_RS03565 ENOG4105C8V SAICAR synthetase HR084_RS03570 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HR084_RS03575 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HR084_RS03580 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HR084_RS03590 ENOG4105CXB phosphoribosylaminoimidazole synthetase HR084_RS03595 ENOG4108V3E phosphoribosylglycinamide formyltransferase HR084_RS03600 ENOG4105DC1 bifunctional purine biosynthesis protein purh HR084_RS03605 ENOG4105C12 Phosphoribosylglycinamide synthetase HR084_RS03615 ENOG4105DVH amino acid HR084_RS03630 ENOG4108R5T secreted protein HR084_RS03635 ENOG4105KGF protein, YerC YecD HR084_RS03640 ENOG4105CBC glutamate synthase HR084_RS03645 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HR084_RS03650 ENOG4105C4R Atp-dependent dna helicase HR084_RS03655 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HR084_RS03665 ENOG4105CRN Aminoglycoside phosphotransferase HR084_RS03670 ENOG4105KT7 mgtC SapB transporter HR084_RS03675 ENOG4105CK7 Sodium proline symporter HR084_RS03680 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HR084_RS03685 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HR084_RS03690 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HR084_RS03695 ENOG4108IG5 Transcriptional regulator HR084_RS03705 ENOG4105CBD Diacylglycerol kinase HR084_RS03710 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HR084_RS03775 ENOG4108HFV HR084_RS03795 ENOG4105CDY transcriptional regulatory protein HR084_RS03805 ENOG4105M4P Tetr family transcriptional regulator HR084_RS03810 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HR084_RS03815 ENOG4107S9F NmrA family HR084_RS03830 ENOG4105WEF catalase HR084_RS03835 ENOG4105M18 -acetyltransferase HR084_RS03850 ENOG4105C2F Histidine kinase HR084_RS03855 ENOG4105EQD regulatoR HR084_RS03860 ENOG410769Z extracellular solute-binding protein family 1 HR084_RS03865 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HR084_RS03870 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HR084_RS03875 ENOG4105F5H Glycosyl Hydrolase Family 88 HR084_RS03880 ENOG41075H3 AraC family transcriptional regulator HR084_RS03885 ENOG4107TDE lipolytic protein G-D-S-L family HR084_RS03900 ENOG4105CX8 fg-gap repeat protein HR084_RS03905 ENOG4105CX8 fg-gap repeat protein HR084_RS03910 ENOG4107TDE lipolytic protein G-D-S-L family HR084_RS03920 ENOG4105EKC HR084_RS03925 ENOG4105E0S extracellular solute-binding protein family 1 HR084_RS03935 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HR084_RS03940 ENOG4105F8D glycoside hydrolase family 4 HR084_RS03945 ENOG4105H67 Protein of unknown function (DUF421) HR084_RS03950 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HR084_RS03955 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HR084_RS03975 ENOG4106I4J membrane HR084_RS03980 ENOG4108PCN EamA-like transporter family HR084_RS03985 ENOG41082F9 transcriptional regulator HR084_RS03990 ENOG41061H0 Monooxygenase HR084_RS03995 ENOG4108R1P HR084_RS04000 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HR084_RS04005 ENOG4105E0M Sulfatase HR084_RS04010 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HR084_RS04020 ENOG41090R9 glycosyltransferase HR084_RS04025 ENOG4107R51 Glycosyl transferase, family 2 HR084_RS04030 ENOG41090R9 glycosyltransferase HR084_RS04035 ENOG4105EU0 Major facilitator Superfamily HR084_RS04045 ENOG4105CUB amino acid HR084_RS04050 ENOG4105C26 Dehydrogenase HR084_RS04055 ENOG4105FKZ Methyl-accepting chemotaxis HR084_RS04060 ENOG4105C5H ABC transporter HR084_RS04070 ENOG4107SWG transcriptional regulator MERR family HR084_RS04075 ENOG4105DXB Major Facilitator superfamily HR084_RS04085 ENOG4105C5H ABC transporter HR084_RS04090 ENOG4105FDU atp-dependent rna helicase HR084_RS04100 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HR084_RS04110 ENOG4105E6M Sulphatase-modifying factor protein HR084_RS04115 ENOG4105E0A ABC, transporter HR084_RS04120 ENOG4108U1V ABC transporter, permease HR084_RS04125 ENOG4105DQ5 transport system permease protein HR084_RS04130 ENOG4108HUF Transporter HR084_RS04145 ENOG4108J20 pectate lyase HR084_RS04150 ENOG4107QPK )-transporter HR084_RS04160 ENOG4108MRH transcriptional regulatory protein HR084_RS04185 ENOG410855V Acylphosphatase HR084_RS04190 ENOG4108RPX mosc domain containing protein HR084_RS04210 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HR084_RS04240 ENOG4105GEU Spore germination protein HR084_RS04250 ENOG4108Q5U germination protein, ger(x)c family HR084_RS04255 ENOG4105E1K spore germination protein HR084_RS04260 ENOG4105C5Y PTS System HR084_RS04265 ENOG4105CG3 alpha amylase, catalytic region HR084_RS04270 ENOG4107414 GntR family transcriptional regulator HR084_RS04275 ENOG4108RCM Nitroreductase HR084_RS04280 ENOG4105CGH 5'-nucleotidase HR084_RS04285 ENOG4107RKG DJ-1/PfpI family HR084_RS04300 ENOG4105KJF protein tyrosine phosphatase HR084_RS04310 ENOG4107U9T Pfam:Ribonuclease_BN HR084_RS04315 ENOG4108ISG Major Facilitator HR084_RS04320 ENOG4105UPD Calcium Proton HR084_RS04330 ENOG4105D8X mechanosensitive ion channel HR084_RS04350 ENOG4106KE4 Dehydrogenase HR084_RS04355 ENOG4105D7N magnesium and cobalt transport protein CorA HR084_RS04365 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HR084_RS04385 ENOG4107RUY (E1 component), alpha subunit HR084_RS04395 ENOG4107QKR Dehydrogenase HR084_RS04405 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HR084_RS04410 ENOG41069DP small acid-soluble spore protein HR084_RS04415 ENOG4105KK4 UPF0060 membrane protein HR084_RS04440 ENOG4105F8D glycoside hydrolase family 4 HR084_RS04445 ENOG4108Q3X Transcriptional regulator HR084_RS04450 ENOG4105CI1 PTS System HR084_RS04460 ENOG4105BZ1 (ABC) transporter HR084_RS04465 ENOG4105BZ1 (ABC) transporter HR084_RS04475 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HR084_RS04480 ENOG4105BZU Histidine kinase HR084_RS04485 ENOG4105WH1 Two component transcriptional regulator luxr family HR084_RS04490 ENOG4105CJ1 ABC, transporter HR084_RS04495 ENOG41090VJ ABC-2 type transporter HR084_RS04500 ENOG4108KYE ABC-2 type transporter HR084_RS04505 ENOG4105U3E Transcriptional regulator HR084_RS04510 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HR084_RS04515 ENOG4105H93 Acyltransferase family HR084_RS04520 ENOG4108YYS metal-dependent hydrolase (By similarity) HR084_RS04525 ENOG4105C0R drug resistance transporter emrb qaca subfamily HR084_RS04530 ENOG410834F Transcriptional regulator HR084_RS04540 ENOG4108MES Periplasmic binding protein HR084_RS04545 ENOG4105DQ5 transport system permease protein HR084_RS04550 ENOG4108IHU transport system permease protein HR084_RS04555 ENOG4105JAB phenazine biosynthesis protein, phzf family HR084_RS04560 ENOG4107Y03 Nitroreductase HR084_RS04575 ENOG4105ECP epimerase HR084_RS04590 ENOG4105F27 Major Facilitator HR084_RS04610 ENOG4106AKJ HR084_RS04615 ENOG4105D74 hydrolase HR084_RS04620 ENOG4105CKK Glycosyl transferase, family 2 HR084_RS04625 ENOG4105EJV Membrane HR084_RS04630 ENOG41067AE Membrane-bound metal-dependent hydrolase HR084_RS04635 ENOG4105CEN a g-specific adenine glycosylase HR084_RS04640 ENOG4106BXE HR084_RS04645 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HR084_RS04660 ENOG4105EVI UPF0374 protein HR084_RS04665 ENOG4105BZ1 (ABC) transporter HR084_RS04670 ENOG4107NBY Membrane HR084_RS04680 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HR084_RS04685 ENOG4105G5W regulator Fur family HR084_RS04795 ENOG4108N23 SpoOM-related protein HR084_RS04810 ENOG4105EC3 peptidase S51, dipeptidase E HR084_RS04815 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HR084_RS04820 ENOG4105DNP FAD linked oxidase domain protein HR084_RS04835 ENOG4105E2Y ABC, transporter HR084_RS04840 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HR084_RS04845 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HR084_RS04850 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HR084_RS04860 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HR084_RS04865 ENOG4107D63 HR084_RS04870 ENOG4105VZ8 Transcriptional regulator HR084_RS04885 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HR084_RS04895 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HR084_RS04915 ENOG4105CYN Serine protein kinase HR084_RS04920 ENOG4106AKX UPF0229 protein HR084_RS04925 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HR084_RS04930 ENOG4105CW7 secretion protein, HlyD family HR084_RS04935 ENOG4105C0R drug resistance transporter emrb qaca subfamily HR084_RS04940 ENOG4105CS1 NAD(P)H quinone oxidoreductase HR084_RS04960 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HR084_RS04965 ENOG4105CZV ABC transporter HR084_RS04970 ENOG4105CJ1 ABC, transporter HR084_RS04975 ENOG4108TU7 Inherit from COG: (ABC) transporter HR084_RS04980 ENOG4105VEQ Cold shock protein HR084_RS04990 ENOG4105BZU Histidine kinase HR084_RS05030 ENOG4108YBP pseudouridine synthase HR084_RS05040 ENOG41080XP Cbs domain HR084_RS05045 ENOG4107YBY Hydrolase HR084_RS05050 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HR084_RS05055 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HR084_RS05060 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HR084_RS05070 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HR084_RS05075 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HR084_RS05085 ENOG4105BZU Histidine kinase HR084_RS05090 ENOG4105WH1 Two component transcriptional regulator luxr family HR084_RS05125 ENOG4105ED1 spovr family HR084_RS05130 ENOG4105G6Z alkaline phosphatase HR084_RS05145 ENOG4105BZN citrate synthase HR084_RS05150 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HR084_RS05155 ENOG4105CUB amino acid HR084_RS05160 ENOG4105C8J )-transporter HR084_RS05165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HR084_RS05180 ENOG4105J37 HR084_RS05185 ENOG4108AEY RNA polymerase sigma factor HR084_RS05190 ENOG4108FN7 Aldo keto reductase HR084_RS05195 ENOG4105F6E Acyl-transferase HR084_RS05200 ENOG4105C37 (CBS) domain HR084_RS05210 ENOG4105CHM Aminotransferase HR084_RS05215 ENOG4105C37 (CBS) domain HR084_RS05225 ENOG4105WMR Protein CrcB homolog HR084_RS05230 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HR084_RS05240 ENOG4105D64 Mechanosensitive ion channel HR084_RS05245 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HR084_RS05250 ENOG4107VMI polysaccharide deacetylase HR084_RS05255 ENOG4105F0I Aminotransferase HR084_RS05275 ENOG4105BZ1 (ABC) transporter HR084_RS05280 ENOG4105BZ1 (ABC) transporter HR084_RS05305 ENOG410839P HR084_RS05315 ENOG4106MP8 UPF0754 membrane protein HR084_RS05320 ENOG4105WZB UPF0342 protein HR084_RS05325 ENOG4105F1N DNA alkylation repair HR084_RS05335 ENOG4105D4P Coproporphyrinogen iii oxidase HR084_RS05340 ENOG4107S91 Sodium hydrogen exchanger HR084_RS05345 ENOG4105NCW Trka-c domain protein HR084_RS05355 ENOG4105CGU Enoyl-CoA hydratase HR084_RS05365 ENOG4108IUX (ABC) transporter HR084_RS05370 ENOG4105RHA ABC transporter, permease HR084_RS05375 ENOG4107VRP DNA repair exonuclease HR084_RS05380 ENOG4106D4I domain protein HR084_RS05385 ENOG4105EQI Metal Dependent Phosphohydrolase HR084_RS05395 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HR084_RS05440 ENOG4105NBU tryptophan transport protein HR084_RS05445 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HR084_RS05450 ENOG4105K59 histidine triad (HIT) protein HR084_RS05485 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HR084_RS05490 ENOG4105BZ4 penicillin-binding protein HR084_RS05495 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HR084_RS05500 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HR084_RS05505 ENOG4105C1Q protoporphyrinogen oxidase HR084_RS05515 ENOG4105ECB domain protein HR084_RS05525 ENOG41090T1 Membrane HR084_RS05535 ENOG4105DER m42 family HR084_RS05550 ENOG4106AXD HR084_RS05555 ENOG4108RQ5 Beta-lactamase domain-containing protein HR084_RS05560 ENOG4105DF9 Lipoate-protein, ligase HR084_RS05570 ENOG4105CEY Amp-dependent synthetase and ligase HR084_RS05580 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HR084_RS05585 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HR084_RS05590 ENOG4105KD7 acetyltransferase HR084_RS05600 ENOG4108HUF Transporter HR084_RS05605 ENOG4107TB6 phosphoglycerate mutase HR084_RS05615 ENOG4107F3J Amp-dependent synthetase and ligase HR084_RS05620 ENOG4107ZYJ bioY protein HR084_RS05625 ENOG4106YBV Methyl-accepting chemotaxis HR084_RS05645 ENOG4105XVF Competence transcription factor HR084_RS05650 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HR084_RS05655 ENOG4105X3H Excalibur domain protein HR084_RS05660 ENOG4105E1V na solute symporter HR084_RS05665 ENOG4106CAD Protein of unknown function (DUF3311) HR084_RS05670 ENOG41060YP HR084_RS05685 ENOG4107SCK Monooxygenase HR084_RS05690 ENOG4108INS Transcriptional regulator HR084_RS05705 ENOG4105TRI Hydrolase HR084_RS05720 ENOG4108KK1 membrane protein AbrB duplication HR084_RS05725 ENOG4106K7D Major facilitator family transporter HR084_RS05730 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HR084_RS05735 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding HR084_RS05750 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HR084_RS05760 ENOG4105EYH Exonuclease HR084_RS05810 ENOG4105ERH Fumarylacetoacetate hydrolase HR084_RS05820 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HR084_RS05830 ENOG4105CAQ asparagine synthetase HR084_RS05845 ENOG4105UQX Mate efflux family protein HR084_RS05850 ENOG4106HBX Transcriptional Regulator AraC Family HR084_RS05855 ENOG4105ETE Transcriptional regulator (LacI family HR084_RS05860 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HR084_RS05865 ENOG4105SF0 DinB family HR084_RS05875 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HR084_RS05880 ENOG4105MYW Pentapeptide repeat protein HR084_RS05885 ENOG4107S9D Alpha beta hydrolase HR084_RS05890 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HR084_RS05895 ENOG4107RIQ Sulfate adenylate transferase HR084_RS05900 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HR084_RS05905 ENOG4108N5B 2-phosphosulfolactate phosphatase HR084_RS05910 ENOG41061P3 phosphosulfolactate synthase HR084_RS05920 ENOG4105DIA mandelate racemase muconate lactonizing HR084_RS05925 ENOG4107RCC Major Facilitator Superfamily HR084_RS05930 ENOG4108SZE gCN5-related N-acetyltransferase HR084_RS05935 ENOG4105MA6 gCN5-related N-acetyltransferase HR084_RS05945 ENOG4108VPT UPF0234 protein HR084_RS05950 ENOG4105QNR S1 RNA binding domain protein HR084_RS05970 ENOG4105K7K Transcriptional regulator HR084_RS05980 ENOG410751J HR084_RS05985 ENOG4105D4Y metalloprotease HR084_RS05990 ENOG4105EPR degv family HR084_RS05995 ENOG4107AYK membrAne HR084_RS06005 ENOG41073B9 HR084_RS06015 ENOG4108KP7 hydrolase HR084_RS06020 ENOG4108MXZ Esterase HR084_RS06025 ENOG4105VG1 fes assembly suf system protein HR084_RS06035 ENOG4105IQ5 FAD linked oxidase domain protein HR084_RS06045 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HR084_RS06050 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HR084_RS06060 ENOG4105C8Y Acetylornithine aminotransferase HR084_RS06065 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HR084_RS06075 ENOG4105DBV ornithine carbamoyltransferase HR084_RS06100 ENOG4107RMD Basic membrane lipoprotein HR084_RS06115 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HR084_RS06120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HR084_RS06130 ENOG4105C3U ABC transporter HR084_RS06135 ENOG4108JQ7 (ABC) transporter HR084_RS06150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HR084_RS06160 ENOG4105C31 Tryptophanyl-tRNA synthetase HR084_RS06165 ENOG4108J59 Extracellular solute-binding protein, family 5 HR084_RS06170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HR084_RS06175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HR084_RS06185 ENOG4108JQ7 (ABC) transporter HR084_RS06200 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HR084_RS06205 ENOG4108ZCF integral membrane protein HR084_RS06215 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HR084_RS06230 ENOG4105DPN Oligoendopeptidase f HR084_RS06240 ENOG4105T58 Dithiol-disulfide isomerase HR084_RS06245 ENOG4108Z18 K06886 hemoglobin HR084_RS06250 ENOG4105E4C Lytic transglycosylase catalytic HR084_RS06255 ENOG4105MIX Adenylate cyclase HR084_RS06270 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HR084_RS06275 ENOG4105EMS pseudouridine synthase HR084_RS06290 ENOG4105ETU transcriptional activator (TenA HR084_RS06295 ENOG4108VEU Thiamine monophosphate synthase HR084_RS06310 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HR084_RS06315 ENOG4105D06 uba thif-type nad fad binding protein HR084_RS06320 ENOG4105DWF phosphomethylpyrimidine kinase HR084_RS06325 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HR084_RS06330 ENOG4107A88 HR084_RS06380 ENOG4105ENA helicase HR084_RS06395 ENOG4108ZMI UPF0477 protein HR084_RS06405 ENOG4105C28 cystathionine HR084_RS06410 ENOG4105C28 cystathionine HR084_RS06415 ENOG4105D9U N-acetyltransferase HR084_RS06420 ENOG4105JHY Membrane HR084_RS06440 ENOG4106BHF HR084_RS06470 ENOG4108PSK reductase HR084_RS06485 ENOG4105DM4 PTS System HR084_RS06490 ENOG4105DG6 mannose-6-phosphate isomerase HR084_RS06495 ENOG4105G7B Protein of unknown function (DUF2992) HR084_RS06500 ENOG4105VMI -acetyltransferase HR084_RS06510 ENOG4108Z66 YbaK ebsC protein HR084_RS06525 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HR084_RS06535 ENOG4108ZJ4 polysaccharide deacetylase HR084_RS06540 ENOG4107CUJ Protein of unknown function (DUF2690) HR084_RS06565 ENOG4108IEG Formate dehydrogenase Alpha subunit HR084_RS06590 ENOG4106A3M Cytochrome p-450 HR084_RS06595 ENOG41087PP glycosyltransferase MGT family HR084_RS06605 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HR084_RS06610 ENOG4105C4B ABC transporter, permease HR084_RS06615 ENOG4108IXI (ABC) transporter HR084_RS06625 ENOG4105Q95 Cupin 2, conserved barrel domain protein HR084_RS06640 ENOG4105D2H Uronic isomerase HR084_RS06645 ENOG4105CT4 transporter HR084_RS06650 ENOG4105DG4 malate L-lactate dehydrogenase HR084_RS06655 ENOG4105CPQ Dehydrogenase HR084_RS06660 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HR084_RS06665 ENOG4105DMW Dehydrogenase reductase HR084_RS06670 ENOG4108I5G Major Facilitator superfamily HR084_RS06675 ENOG4107KJX Transcriptional regulator HR084_RS06680 ENOG4107QZW Altronate oxidoreductase HR084_RS06685 ENOG4105CTX dehydratase HR084_RS06690 ENOG4107TSN permease HR084_RS06700 ENOG4105JD4 ATPase yjob HR084_RS06715 ENOG41068K0 YCII-related domain HR084_RS06720 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HR084_RS06725 ENOG4105KWG Pfam:DUF1696 HR084_RS06730 ENOG4105K7W phage-related replication protein HR084_RS06735 ENOG4105WEF catalase HR084_RS06740 ENOG410635T phage-like element pbsx protein HR084_RS06785 ENOG4108TFU terminase (Small subunit) HR084_RS06790 ENOG4105IG6 Phage terminase, large subunit HR084_RS06795 ENOG4108MDF Phage Portal Protein HR084_RS06820 ENOG41060SN HR084_RS06835 ENOG4105PQS phage protein HR084_RS06840 ENOG4105FR7 XkdM protein, phage-like element PBSX HR084_RS06845 ENOG4105MTC XkdN-like protein HR084_RS06855 ENOG4108FKH Transglycosylase SLT domain HR084_RS06855 ENOG4108FKH Transglycosylase SLT domain HR084_RS06860 ENOG4108WZM domain protein HR084_RS06865 ENOG4105X7F HR084_RS06875 ENOG4105MFU Protein of unknown function (DUF2634) HR084_RS06880 ENOG41066EA baseplate J family protein HR084_RS06885 ENOG410906S phage-like element pbsx protein xkdt HR084_RS06895 ENOG41068G1 HR084_RS06925 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HR084_RS06945 ENOG4105CJ3 phosphate transporter HR084_RS06950 ENOG4107GRR phosphate transport regulator HR084_RS06955 ENOG4107R7I amino acid HR084_RS06965 ENOG4105EDW glycosyl transferase, family 39 HR084_RS06970 ENOG4105CKK Glycosyl transferase, family 2 HR084_RS06975 ENOG4105C0H protease HR084_RS06985 ENOG4108ME1 Peptidase M55 D-aminopeptidase HR084_RS06990 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HR084_RS06995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HR084_RS07000 ENOG4105C3U ABC transporter HR084_RS07010 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HR084_RS07015 ENOG4105DTQ mandelate racemase muconate lactonizing HR084_RS07020 ENOG4107SN7 NLP P60 protein HR084_RS07025 ENOG4108JQ7 (ABC) transporter HR084_RS07030 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HR084_RS07035 ENOG4107TUM Amidinotransferase HR084_RS07040 ENOG4108S4H thioesterase Superfamily protein HR084_RS07045 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HR084_RS07065 ENOG4108428 Inherit from COG: -acetyltransferase HR084_RS07075 ENOG41080TC multidrug resistance protein HR084_RS07080 ENOG4105CIY formyltetrahydrofolate deformylase HR084_RS07085 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HR084_RS07100 ENOG4105K56 Transcriptional regulator HR084_RS07105 ENOG4108ZHJ Organic hydroperoxide resistance protein HR084_RS07115 ENOG4107Y2X deaminase HR084_RS07120 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HR084_RS07125 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HR084_RS07135 ENOG4108W7F transporter, permease HR084_RS07140 ENOG4108JJB ABC transporter HR084_RS07145 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HR084_RS07150 ENOG4108X43 YKOF domain protein HR084_RS07155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HR084_RS07160 ENOG41062D9 Histidine kinase HR084_RS07170 ENOG4106849 propeptide, pepSY amd peptidase M4 HR084_RS07180 ENOG4105CJW magnesium transporter HR084_RS07185 ENOG4105V75 Transcriptional regulator HR084_RS07230 ENOG4105DQE DNA ligase HR084_RS07235 ENOG4105FDF Could be involved in DNA repair (By similarity) HR084_RS07240 ENOG4105BZU Histidine kinase HR084_RS07245 ENOG4107T5V SNARE associated Golgi HR084_RS07250 ENOG4107TS3 membrane protein, TerC HR084_RS07255 ENOG4108WZW RNA polymerase sigma HR084_RS07265 ENOG410681C small acid-soluble spore protein HR084_RS07275 ENOG4105D0M Protease HtpX homolog HR084_RS07295 ENOG4108TGC Acyltransferase HR084_RS07300 ENOG4105BZU Histidine kinase HR084_RS07305 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HR084_RS07315 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HR084_RS07320 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HR084_RS07325 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HR084_RS07335 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit HR084_RS07340 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HR084_RS07345 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HR084_RS07350 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HR084_RS07370 ENOG4105BZU Histidine kinase HR084_RS07375 ENOG41090MY MarR family Transcriptional regulator HR084_RS07380 ENOG4105ER2 Ompa motb domain protein HR084_RS07385 ENOG4105E14 MotA TolQ exbB proton channel HR084_RS07395 ENOG4108K88 Membrane HR084_RS07400 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HR084_RS07405 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HR084_RS07410 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HR084_RS07415 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HR084_RS07425 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HR084_RS07430 ENOG4105FEA Spore maturation protein HR084_RS07460 ENOG4105F0V Cell wall hydrolase HR084_RS07475 ENOG4105C59 p-type ATPase HR084_RS07485 ENOG4105DC7 peptidase M24 HR084_RS07495 ENOG4105CID antiterminator HR084_RS07505 ENOG4105KRI phosphocarrier protein (HPr HR084_RS07510 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HR084_RS07520 ENOG4105F6S Spore photoproduct lyase HR084_RS07530 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HR084_RS07535 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HR084_RS07540 ENOG4105K4I Scp-like extracellular HR084_RS07550 ENOG4105BZU Histidine kinase HR084_RS07555 ENOG4105CHM Aminotransferase HR084_RS07565 ENOG4107R88 Chemotaxis protein (CheV) HR084_RS07570 ENOG4105UIN HR084_RS07580 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HR084_RS07590 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HR084_RS07595 ENOG4105EPM Diguanylate phosphodiesterase HR084_RS07600 ENOG4107IN1 Protein of unknown function (DUF1797) HR084_RS07605 ENOG4108XRC Protein of unknown function (DUF458) HR084_RS07635 ENOG4105NQC Flavodoxin HR084_RS07645 ENOG4105CH2 amidohydrolase HR084_RS07655 ENOG4105D8X mechanosensitive ion channel HR084_RS07660 ENOG4105D3R alkyl hydroperoxide reductase HR084_RS07665 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HR084_RS07680 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HR084_RS07685 ENOG4105D06 uba thif-type nad fad binding protein HR084_RS07690 ENOG4105CVM Molybdenum cofactor synthesis domain protein HR084_RS07695 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HR084_RS07700 ENOG4108ZAF Molybdopterin HR084_RS07705 ENOG41067WU Molybdopterin converting factor (Subunit 1) HR084_RS07710 ENOG4105BZ1 (ABC) transporter HR084_RS07715 ENOG4105BZ1 (ABC) transporter HR084_RS07725 ENOG4107X8C Efflux transporter RND family MFP subunit HR084_RS07730 ENOG4105C19 ABC transporter HR084_RS07735 ENOG4107RBB ABC transporter, permease HR084_RS07740 ENOG4105E98 transcriptional regulator DeoR family HR084_RS07745 ENOG4105DE4 1-phosphofructokinase HR084_RS07750 ENOG4105DM4 PTS System HR084_RS07755 ENOG4105C3F Signal peptidase i HR084_RS07765 ENOG4105C5H ABC transporter HR084_RS07770 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HR084_RS07795 ENOG4105BZU Histidine kinase HR084_RS07805 ENOG4107ZYR domain protein HR084_RS07815 ENOG4105CN5 Metallo-Beta-Lactamase HR084_RS07825 ENOG4108X4Q Hydrolase HR084_RS07830 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HR084_RS07850 ENOG4105CPP Dehydrogenase, E1 component HR084_RS07855 ENOG4105C7S Dehydrogenase HR084_RS07860 ENOG4107QN2 dihydrolipoyl dehydrogenase HR084_RS07875 ENOG4105CXN decarboxylase HR084_RS07880 ENOG4105WBI UPF0223 protein HR084_RS07895 ENOG4105ECY inositol monophosphatase HR084_RS07905 ENOG4105JQZ Methyltransferase HR084_RS07945 ENOG4105CI3 gtp-binding protein typa HR084_RS07950 ENOG4105QA2 HR084_RS07965 ENOG4108IAB Phoh family HR084_RS07975 ENOG4105CSV Glutaminase HR084_RS07980 ENOG4105ZPI UPF0358 protein HR084_RS07985 ENOG4105CNI cell division protein FtsW HR084_RS07990 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HR084_RS08000 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HR084_RS08010 ENOG4105BZ9 Cytochrome C oxidase, subunit I HR084_RS08015 ENOG4105CCU oxidase (Subunit III) HR084_RS08020 ENOG41064X9 cytochrome C oxidase subunit IV HR084_RS08035 ENOG41080XQ Signal transduction protein with cbs domains HR084_RS08040 ENOG4106UY4 Inherit from COG: Scp-like extracellular HR084_RS08060 ENOG4105WUC UPF0298 protein HR084_RS08065 ENOG4106H78 methyltransferase HR084_RS08070 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HR084_RS08075 ENOG4105H20 Sporulation integral membrane protein YlbJ HR084_RS08080 ENOG4105D78 K07001 NTE family protein HR084_RS08085 ENOG41063PX domain protein HR084_RS08090 ENOG4105CDE UPF0348 protein HR084_RS08100 ENOG4105KNH Nucleic acid-binding protein HR084_RS08130 ENOG4108V6E Cell division protein mraZ HR084_RS08135 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HR084_RS08145 ENOG4105CJN penicillin-binding protein HR084_RS08150 ENOG4105CJN penicillin-binding protein HR084_RS08155 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HR084_RS08160 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HR084_RS08165 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HR084_RS08170 ENOG4105CNI cell division protein FtsW HR084_RS08175 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HR084_RS08180 ENOG4105D4A Cell wall formation (By similarity) HR084_RS08185 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HR084_RS08190 ENOG4108R2U division initiation protein HR084_RS08200 ENOG4105K67 small basic protein HR084_RS08205 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HR084_RS08210 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HR084_RS08235 ENOG4105FFI sigma-e processing peptidase spoiiga HR084_RS08240 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HR084_RS08250 ENOG4105DKW ABC transporter HR084_RS08260 ENOG4105WR5 sporulation protein, YlmC YmxH family HR084_RS08265 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HR084_RS08270 ENOG4105DFA alanine racemase domain protein HR084_RS08275 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HR084_RS08280 ENOG41067XK integral membrane protein HR084_RS08285 ENOG4105DBK s4 domain protein HR084_RS08295 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HR084_RS08305 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HR084_RS08310 ENOG4105C34 Pseudouridine synthase HR084_RS08315 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HR084_RS08325 ENOG4105CXT aspartate transcarbamylase HR084_RS08335 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HR084_RS08340 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HR084_RS08345 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HR084_RS08350 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HR084_RS08355 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HR084_RS08360 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HR084_RS08365 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HR084_RS08375 ENOG4107S4M Sulfate adenylate transferase HR084_RS08380 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HR084_RS08385 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HR084_RS08390 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HR084_RS08395 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HR084_RS08410 ENOG4105DSJ YicC domain protein HR084_RS08415 ENOG4105KC4 UPF0296 protein HR084_RS08420 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HR084_RS08430 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HR084_RS08435 ENOG4105C25 Primosomal protein n' HR084_RS08440 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HR084_RS08445 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HR084_RS08450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HR084_RS08455 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HR084_RS08460 ENOG4108ZF3 Phosphatase HR084_RS08465 ENOG4105D9P serine threonine protein kinase HR084_RS08470 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HR084_RS08475 ENOG4105DJV ribulose-phosphate 3-epimerase HR084_RS08480 ENOG4105FJ0 thiamine HR084_RS08490 ENOG4105VB9 50S ribosomal protein l28 HR084_RS08495 ENOG4108ZAA Alkaline-shock protein HR084_RS08500 ENOG4105DP4 dak2 domain fusion protein ylov HR084_RS08510 ENOG4105EJQ L-serine dehydratase HR084_RS08515 ENOG4105CB5 ATP-dependent DNA helicase recG HR084_RS08520 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HR084_RS08530 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HR084_RS08535 ENOG4105CHR reductase HR084_RS08545 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HR084_RS08550 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HR084_RS08555 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HR084_RS08565 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HR084_RS08575 ENOG4105K5M 30s ribosomal protein S16 HR084_RS08580 ENOG4108BW8 UPF0109 protein HR084_RS08590 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HR084_RS08595 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HR084_RS08600 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HR084_RS08605 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HR084_RS08610 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HR084_RS08620 ENOG4105VM1 flagellar HR084_RS08625 ENOG4105CMV Succinyl-CoA synthetase subunit beta HR084_RS08630 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HR084_RS08635 ENOG4105C79 DNA protecting protein DprA HR084_RS08640 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HR084_RS08645 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HR084_RS08650 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HR084_RS08655 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HR084_RS08660 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HR084_RS08670 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HR084_RS08675 ENOG4108ZC9 flagellar basal-body rod protein flgc HR084_RS08680 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HR084_RS08685 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HR084_RS08690 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HR084_RS08705 ENOG4106YF4 Flagellar biosynthesis chaperone HR084_RS08715 ENOG410696Y Flagellar hook-length control protein HR084_RS08720 ENOG410822I Flagellar hook capping protein HR084_RS08725 ENOG4108JQA flagellar HR084_RS08730 ENOG41068WV flagellar FlbD family protein HR084_RS08740 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HR084_RS08745 ENOG4105DD5 Flagellar motor switch protein HR084_RS08750 ENOG4107YTP response regulator receiver protein HR084_RS08760 ENOG4105CN7 Flagellar biosynthetic protein FliP HR084_RS08765 ENOG4105VS8 Flagellar biosynthetic protein fliq HR084_RS08770 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HR084_RS08775 ENOG4105D00 flagellar biosynthetic protein flhB HR084_RS08780 ENOG4105D7B Flagellar biosynthesis protein flha HR084_RS08785 ENOG4105FZW flagellar biosynthesis regulator FlhF HR084_RS08795 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HR084_RS08800 ENOG4105CBS Chea signal transduction histidine kinase HR084_RS08805 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HR084_RS08820 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HR084_RS08830 ENOG4105CE9 30S ribosomal protein S2 HR084_RS08835 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HR084_RS08845 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HR084_RS08850 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HR084_RS08855 ENOG4105KNE Phosphatidate cytidylyltransferase HR084_RS08865 ENOG4105DZP Membrane-associated zinc metalloprotease HR084_RS08870 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HR084_RS08875 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HR084_RS08880 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HR084_RS08885 ENOG4105CHV Transcription elongation factor NusA HR084_RS08890 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HR084_RS08895 ENOG4105VHM ribosomal protein HR084_RS08900 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HR084_RS08905 ENOG4105W7A Protein of unknown function (DUF503) HR084_RS08910 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HR084_RS08915 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HR084_RS08920 ENOG4105DTN riboflavin biosynthesis protein ribF HR084_RS08925 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HR084_RS08930 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HR084_RS08940 ENOG4105C1V Peptidase, M16 HR084_RS08950 ENOG4105E35 Dipicolinate synthase subunit A HR084_RS08955 ENOG4108S0H Dipicolinic acid synthetase, b subunit HR084_RS08960 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HR084_RS08970 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HR084_RS08980 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HR084_RS08990 ENOG4105CNU cell division protein FtsK HR084_RS08995 ENOG4105FDP GntR family transcriptional regulator HR084_RS09015 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HR084_RS09020 ENOG4105XZV Protein of unknown function (DUF3243) HR084_RS09035 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HR084_RS09040 ENOG4105CEV competence damage-inducible protein HR084_RS09050 ENOG4108A04 Beta-lactamase HR084_RS09055 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HR084_RS09060 ENOG4105D48 metallophosphoesterase HR084_RS09065 ENOG4105MCT stage V sporulation protein S HR084_RS09075 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HR084_RS09080 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HR084_RS09095 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HR084_RS09100 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HR084_RS09110 ENOG4105IIP Membrane HR084_RS09115 ENOG4105W1N transcriptional regulator HR084_RS09120 ENOG4108151 Beta-lactamase domain protein HR084_RS09130 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HR084_RS09140 ENOG4107QKG PfaD family HR084_RS09145 ENOG41062T2 Acyl carrier protein HR084_RS09150 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase HR084_RS09155 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HR084_RS09160 ENOG4108MGH Enoyl-CoA hydratase HR084_RS09165 ENOG4108KQ6 Enoyl-CoA hydratase HR084_RS09170 ENOG4105C0W non-ribosomal peptide synthetase HR084_RS09175 ENOG4107SQU synthase HR084_RS09185 ENOG4105C0W non-ribosomal peptide synthetase HR084_RS09195 ENOG4106A3M Cytochrome p-450 HR084_RS09210 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HR084_RS09220 ENOG4105K7W phage-related replication protein HR084_RS09225 ENOG4108X3M OsmC Ohr family protein HR084_RS09230 ENOG410814C multidrug resistance protein HR084_RS09250 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HR084_RS09255 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HR084_RS09270 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HR084_RS09275 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HR084_RS09280 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HR084_RS09285 ENOG4105U6W MutT NUDIX family protein HR084_RS09290 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HR084_RS09295 ENOG4106F1P AAA ATPase, central domain protein HR084_RS09300 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HR084_RS09305 ENOG4105CXI aluminum resistance protein HR084_RS09310 ENOG4105KV4 Transcriptional regulator HR084_RS09315 ENOG4105C5F glutamine synthetase HR084_RS09350 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HR084_RS09405 ENOG41079P0 HR084_RS09435 ENOG4106WTF Glycosyl transferase, family 2 HR084_RS09440 ENOG4107RGC Glycosyl transferase, family 2 HR084_RS09465 ENOG4107NTZ HR084_RS09480 ENOG410907G HR084_RS09495 ENOG4105CT4 transporter HR084_RS09500 ENOG4105DSG hydrolase family 43 HR084_RS09505 ENOG4105E2R ROK family HR084_RS09510 ENOG4105C93 Xylose Isomerase HR084_RS09515 ENOG4105CMG Carbohydrate kinase HR084_RS09520 ENOG4107Y9E nuclease HR084_RS09525 ENOG4105C54 Major Facilitator superfamily HR084_RS09530 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HR084_RS09540 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HR084_RS09610 ENOG4108Q8B Spore germination protein HR084_RS09615 ENOG4108NHD germination protein HR084_RS09630 ENOG4105FVX HR084_RS09640 ENOG4105K7W phage-related replication protein HR084_RS09650 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HR084_RS09655 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HR084_RS09665 ENOG4108SVB resolvase HR084_RS09670 ENOG4105VPS UPF0291 protein HR084_RS09675 ENOG4105CV1 Transketolase (EC 2.2.1.1) HR084_RS09695 ENOG4107QIV Cytochrome c biogenesis protein HR084_RS09720 ENOG4107DZX Small, acid-soluble spore protein P HR084_RS09730 ENOG4108I0Z Aconitate hydratase HR084_RS09735 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HR084_RS09750 ENOG41067CD Small, acid-soluble spore protein Tlp HR084_RS09760 ENOG4105MI2 HR084_RS09765 ENOG4105W8X HesB YadR YfhF-family protein HR084_RS09770 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HR084_RS09775 ENOG4105K4P CoA-binding domain protein HR084_RS09780 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HR084_RS09800 ENOG4107QWR cellulase (EC 3.2.1.4) HR084_RS09810 ENOG4108MYR Secreted protein HR084_RS09815 ENOG4107SYN Glycosyl hydrolases family 43 HR084_RS09825 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HR084_RS09830 ENOG4107T5V SNARE associated Golgi HR084_RS09840 ENOG4107QX3 carboxylase HR084_RS09845 ENOG4105E39 Enoyl-CoA hydratase HR084_RS09850 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HR084_RS09855 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HR084_RS09860 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HR084_RS09865 ENOG4105CEY Amp-dependent synthetase and ligase HR084_RS09870 ENOG4105C1G acyl-Coa dehydrogenase HR084_RS09885 ENOG4105F32 YngK protein HR084_RS09890 ENOG4106U2H Protein of unknown function (DUF1360) HR084_RS09900 ENOG4105CEY Amp-dependent synthetase and ligase HR084_RS09905 ENOG4105C0W non-ribosomal peptide synthetase HR084_RS09915 ENOG4105C0W non-ribosomal peptide synthetase HR084_RS09920 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HR084_RS09925 ENOG4108N2V aldose 1-epimerase HR084_RS09930 ENOG4107QJQ Mate efflux family protein HR084_RS09955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HR084_RS09960 ENOG4105SKE transcriptional Regulator LysR family HR084_RS09965 ENOG4105CB2 alcohol dehydrogenase HR084_RS09970 ENOG4105BZ8 glutamate synthase HR084_RS09975 ENOG4105CBC glutamate synthase HR084_RS09980 ENOG4105C5Q Transcriptional regulator HR084_RS09985 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HR084_RS09990 ENOG4105II7 pyrroline-5-carboxylate reductase HR084_RS10010 ENOG4108UB7 HR084_RS10015 ENOG41068WN HR084_RS10035 ENOG4105IE8 Alpha-ketoglutarate permease HR084_RS10040 ENOG4107U6E carbohydrate kinase FGGY HR084_RS10045 ENOG4108M3J Dehydrogenase HR084_RS10050 ENOG4108J2R molybdopterin oxidoreductase HR084_RS10080 ENOG4105EC8 Methyl-accepting chemotaxis HR084_RS10090 ENOG4108YQE rare lipoprotein a HR084_RS10095 ENOG4105XPP Protein of unknown function (DUF1275) HR084_RS10100 ENOG4108NR7 pectate lyase HR084_RS10105 ENOG4108RAV Conserved protein HR084_RS10125 ENOG4105EPI acetyltransferase, (GNAT) family HR084_RS10145 ENOG41073R8 VanW family HR084_RS10160 ENOG4105NX3 Membrane HR084_RS10170 ENOG4108Q5Y Membrane HR084_RS10180 ENOG4108V4B ThiJ pfpI HR084_RS10185 ENOG4108J4B Beta-lactamase HR084_RS10200 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HR084_RS10205 ENOG4107T94 Endo-14-beta-xylanase HR084_RS10210 ENOG4105YB8 TM2 domain containing protein HR084_RS10215 ENOG4108IMY Transcriptional regulator HR084_RS10335 ENOG410780I phosphoprotein phosphatase activity HR084_RS10375 ENOG4106BHF HR084_RS10390 ENOG4108Z7R Chaperone CsaA HR084_RS10395 ENOG4105FTV AraC Family Transcriptional Regulator HR084_RS10400 ENOG4108HJF gCN5-related N-acetyltransferase HR084_RS10410 ENOG4108W8B Beta-lactamase domain protein HR084_RS10420 ENOG4105D29 Helix-turn-helix type 11 domain protein HR084_RS10430 ENOG4105KTU Transcriptional regulator, arsr family HR084_RS10440 ENOG4108SJC Membrane HR084_RS10460 ENOG4105ECK Fatty Acid Desaturase HR084_RS10465 ENOG4108ZGX Histidine kinase HR084_RS10470 ENOG4108S01 response regulator HR084_RS10475 ENOG41069ER domain protein HR084_RS10480 ENOG4105C9U ATP-dependent DNA helicase RecQ HR084_RS10490 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HR084_RS10495 ENOG4105SCY DNAK suppressor HR084_RS10535 ENOG4105C26 Dehydrogenase HR084_RS10540 ENOG4105EWU Squalene--hopene cyclase HR084_RS10545 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HR084_RS10550 ENOG4105C8J )-transporter HR084_RS10555 ENOG4105C09 Bile acid HR084_RS10560 ENOG4105C7S Dehydrogenase HR084_RS10570 ENOG4107T89 von Willebrand factor, type A HR084_RS10575 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HR084_RS10585 ENOG4105K4H Nlp p60 protein HR084_RS10590 ENOG41087PP glycosyltransferase MGT family HR084_RS10600 ENOG4107QMU Mate efflux family protein HR084_RS10605 ENOG4106SCS STAS domain HR084_RS10625 ENOG4105FR1 rard protein HR084_RS10645 ENOG41090U3 tautomerase HR084_RS10660 ENOG4105FBA Phospholipase Carboxylesterase HR084_RS10675 ENOG4105E1V na solute symporter HR084_RS10695 ENOG4108VXD carboxy-peptidase HR084_RS10700 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HR084_RS10710 ENOG4106Z5R HR084_RS10715 ENOG410841Q phosphoesterase PA-phosphatase related protein HR084_RS10745 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HR084_RS10750 ENOG4108TSC N-acetyltransferase HR084_RS10755 ENOG4107S4Y M20 DapE family protein YgeY HR084_RS10770 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HR084_RS10810 ENOG4107T32 3-phytase (EC 3.1.3.8) HR084_RS10815 ENOG4105C5E polysaccharide biosynthesis protein HR084_RS10820 ENOG4105E0X reductase HR084_RS10825 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HR084_RS10845 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HR084_RS10850 ENOG41090WU lipolytic protein G-D-S-L family HR084_RS10855 ENOG4108KF3 Electron transport protein SCO1 SenC HR084_RS10865 ENOG4105C7B Threonine dehydratase HR084_RS10875 ENOG4108UT2 hemolysin iii HR084_RS10885 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HR084_RS10890 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HR084_RS10905 ENOG4107YX5 Pfam:DUF548 HR084_RS10910 ENOG4108Y6J UPF0403 protein HR084_RS10915 ENOG4105C01 Dihydroxy-acid dehydratase HR084_RS10930 ENOG4108V06 Glutathione peroxidase HR084_RS10935 ENOG4105CVG Homoserine O-transsuccinylase HR084_RS10980 ENOG41081VK Ribonuclease HR084_RS11005 ENOG410890F Dynamin family HR084_RS11020 ENOG41065KQ synthase HR084_RS11025 ENOG4105C2W permease HR084_RS11030 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HR084_RS11035 ENOG4105CTD carboxy-peptidase HR084_RS11040 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HR084_RS11045 ENOG4108UHU Aldolase HR084_RS11050 ENOG4105D7K pfkb domain protein HR084_RS11055 ENOG4108M60 Transcriptional regulator HR084_RS11065 ENOG4105CHR reductase HR084_RS11070 ENOG4105DVT helicase HR084_RS11085 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HR084_RS11100 ENOG4108UKS UPF0398 protein HR084_RS11115 ENOG4107X2U Inherit from COG: Exonuclease-like protein HR084_RS11120 ENOG4108I5C dEAD DEAH box helicase HR084_RS11170 ENOG4105BZ4 penicillin-binding protein HR084_RS11180 ENOG4105CSM endonuclease III HR084_RS11190 ENOG4105C5S asparaginyl-tRNA synthetase HR084_RS11195 ENOG4105CHM Aminotransferase HR084_RS11205 ENOG4105YAC HR084_RS11210 ENOG4105DVT helicase HR084_RS11215 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HR084_RS11220 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HR084_RS11225 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HR084_RS11230 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HR084_RS11235 ENOG4105DJ0 Poly(A) Polymerase HR084_RS11240 ENOG4105CPK Glycosyl transferase (Group 1 HR084_RS11245 ENOG4105FJR Lmbe family HR084_RS11250 ENOG4108Z5K methylglyoxal synthase HR084_RS11255 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HR084_RS11260 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HR084_RS11265 ENOG4108JYZ YitT family HR084_RS11285 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HR084_RS11305 ENOG41068YB TPR repeat-containing protein HR084_RS11310 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HR084_RS11320 ENOG4105CIH Imidazole acetol-phosphate transaminase HR084_RS11330 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HR084_RS11335 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HR084_RS11345 ENOG4108I0Q anthranilate phosphoribosyltransferase HR084_RS11350 ENOG4105CRQ synthase (Component I) HR084_RS11355 ENOG4105KHN chorismate mutase HR084_RS11360 ENOG4105D49 3-dehydroquinate synthase HR084_RS11365 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HR084_RS11370 ENOG4105BZU Histidine kinase HR084_RS11375 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HR084_RS11380 ENOG4105EAH synthase HR084_RS11385 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HR084_RS11390 ENOG4105XXQ heptaprenyl diphosphate synthase component I HR084_RS11400 ENOG4105EUJ GTP cyclohydrolase i HR084_RS11405 ENOG4105K70 DNA-binding protein HR084_RS11410 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HR084_RS11425 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HR084_RS11430 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HR084_RS11435 ENOG41065D1 HR084_RS11440 ENOG4105S2F HR084_RS11455 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HR084_RS11460 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HR084_RS11465 ENOG4105CAT Cytidine monophosphate kinase HR084_RS11480 ENOG4105MSI germination protein ypeb HR084_RS11490 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HR084_RS11495 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HR084_RS11510 ENOG4107RGJ metallophosphoesterase HR084_RS11525 ENOG4105I7S Abortive infection protein HR084_RS11530 ENOG4105C9U ATP-dependent DNA helicase RecQ HR084_RS11535 ENOG4105T7X HR084_RS11545 ENOG4108SAX Membrane HR084_RS11550 ENOG4108JQ1 Dehydrogenase HR084_RS11555 ENOG4105FF2 Type I DHQase HR084_RS11570 ENOG4105BZU Histidine kinase HR084_RS11575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HR084_RS11580 ENOG4105CRE cytochrome C HR084_RS11585 ENOG4107TWT Cytochrome c biogenesis protein HR084_RS11595 ENOG4105FE9 pseudouridine synthase HR084_RS11605 ENOG4108JIC nucleoside recognition domain protein HR084_RS11610 ENOG4105DZ1 carboxypeptidase HR084_RS11620 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HR084_RS11625 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HR084_RS11640 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HR084_RS11645 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HR084_RS11650 ENOG4108R6K riboflavin synthase, subunit alpha HR084_RS11655 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HR084_RS11665 ENOG4105C3F Signal peptidase i HR084_RS11675 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) HR084_RS11695 ENOG4107ZE5 PPIases accelerate the folding of proteins HR084_RS11700 ENOG4105PTM secreted protein HR084_RS11705 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HR084_RS11715 ENOG4105G6R Stage v sporulation protein ae HR084_RS11725 ENOG4105CZ3 stage V sporulation protein ad HR084_RS11730 ENOG41090VF Stage v sporulation protein ac HR084_RS11745 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HR084_RS11750 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HR084_RS11755 ENOG41082AN stage II sporulation protein HR084_RS11760 ENOG4105DZ1 carboxypeptidase HR084_RS11765 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HR084_RS11770 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HR084_RS11775 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HR084_RS11785 ENOG4105I3K Ferric uptake regulator, Fur family HR084_RS11790 ENOG4105MZ9 stage II sporulation protein m HR084_RS11805 ENOG4105DFD Na H antiporter HR084_RS11810 ENOG4108IJ0 Aspartate ammonia-lyase HR084_RS11815 ENOG4105HDK L-asparaginase HR084_RS11820 ENOG4108IMY Transcriptional regulator HR084_RS11830 ENOG4108YZ4 nudix hydrolase HR084_RS11840 ENOG4105CPC Aldo Keto reductase HR084_RS11860 ENOG4106HZJ HR084_RS11865 ENOG4105RHY Pfam:UPF0157 HR084_RS11870 ENOG4105KAC Antibiotic biosynthesis monooxygenase HR084_RS11875 ENOG4108XET gCN5-related N-acetyltransferase HR084_RS11885 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HR084_RS11895 ENOG4105E5W Transporter HR084_RS11905 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HR084_RS11920 ENOG4108IXY short-chain dehydrogenase reductase HR084_RS11925 ENOG41069FQ Metallo-beta-lactamase superfamily HR084_RS11930 ENOG4105II7 pyrroline-5-carboxylate reductase HR084_RS11940 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HR084_RS11950 ENOG410861F 50S ribosomal protein L33 HR084_RS11955 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HR084_RS11960 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HR084_RS11965 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HR084_RS11970 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HR084_RS11980 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HR084_RS11985 ENOG4108NA0 Uncharacterized conserved protein (COG2071) HR084_RS11990 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HR084_RS11995 ENOG4108HNZ carboxyl transferase HR084_RS12000 ENOG4108ZVT methylmalonyl-coA epimerase HR084_RS12010 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HR084_RS12015 ENOG4108QEG Membrane HR084_RS12020 ENOG4105CDA abc transporter atp-binding protein HR084_RS12025 ENOG4105E5Q amino acid AbC transporter HR084_RS12030 ENOG4108HW3 (ABC) transporter HR084_RS12035 ENOG4108Y6J UPF0403 protein HR084_RS12040 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HR084_RS12055 ENOG4105C7S Dehydrogenase HR084_RS12060 ENOG4105CPP Dehydrogenase, E1 component HR084_RS12075 ENOG4105CKM Branched-chain carboxylic acid kinase HR084_RS12080 ENOG4107RDP Dehydrogenase HR084_RS12090 ENOG4108JUB Transcriptional regulator HR084_RS12095 ENOG4106CCJ Protein of unknown function (DUF2627) HR084_RS12100 ENOG4105CR4 methylisocitrate lyase HR084_RS12105 ENOG4105DXD 2-methylcitrate dehydratase HR084_RS12115 ENOG4105C1G acyl-Coa dehydrogenase HR084_RS12120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HR084_RS12130 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HR084_RS12135 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HR084_RS12150 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HR084_RS12155 ENOG4107QQR Sporulation HR084_RS12160 ENOG4105S1Z Stage IV sporulation protein B HR084_RS12165 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HR084_RS12170 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HR084_RS12175 ENOG4105DX0 Hemolysin A HR084_RS12185 ENOG4105CTB Polyprenyl synthetase HR084_RS12190 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HR084_RS12195 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HR084_RS12200 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HR084_RS12205 ENOG4105M7K Involved in the transcription termination process (By similarity) HR084_RS12210 ENOG4108ZSR alkaline shock protein HR084_RS12215 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HR084_RS12235 ENOG410644B Stage III sporulation protein af HR084_RS12245 ENOG4105KQ4 Stage iii sporulation protein ad HR084_RS12250 ENOG4108CQH stage III sporulation protein AC HR084_RS12255 ENOG4105KR5 Stage iii sporulation protein HR084_RS12260 ENOG4105CD2 stage iii sporulation protein aa HR084_RS12270 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HR084_RS12275 ENOG4105DC7 peptidase M24 HR084_RS12280 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HR084_RS12290 ENOG4105CBJ Metal-dependent enzyme HR084_RS12305 ENOG4105KST dependent repressor HR084_RS12310 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HR084_RS12315 ENOG4105WZW rhodanese family HR084_RS12320 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HR084_RS12325 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HR084_RS12330 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HR084_RS12335 ENOG4105C0D helicase HR084_RS12350 ENOG4108IMY Transcriptional regulator HR084_RS12360 ENOG4105VFR signal peptidase HR084_RS12420 ENOG4105C37 (CBS) domain HR084_RS12445 ENOG4105C5X domain protein HR084_RS12470 ENOG4105E0M Sulfatase HR084_RS12485 ENOG4107ZXI Rhomboid family HR084_RS12495 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HR084_RS12520 ENOG41068DG YceG-like family HR084_RS12525 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HR084_RS12530 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HR084_RS12535 ENOG4105E2Z phosphate ABC transporter (Permease HR084_RS12540 ENOG4105C8U phosphate abc transporter HR084_RS12545 ENOG4105CVA phosphate HR084_RS12550 ENOG4107RF6 penicillin-binding protein HR084_RS12560 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HR084_RS12565 ENOG4105SXS Protein of unknown function (DUF456) HR084_RS12580 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HR084_RS12585 ENOG41063Y9 HR084_RS12590 ENOG4108U5J '-nucleotidase HR084_RS12595 ENOG4105N80 Ferric uptake regulator, Fur family HR084_RS12600 ENOG4108JYZ YitT family HR084_RS12605 ENOG41069ZM Protein of unknown function (DUF2624) HR084_RS12610 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HR084_RS12625 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HR084_RS12630 ENOG4105EGD dinuclear metal center protein, YbgI family HR084_RS12645 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HR084_RS12650 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HR084_RS12655 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 HR084_RS12660 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HR084_RS12670 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HR084_RS12675 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HR084_RS12680 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HR084_RS12690 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HR084_RS12695 ENOG4105KG3 cytidine deaminase HR084_RS12700 ENOG4107YR5 Diacylglycerol kinase HR084_RS12705 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HR084_RS12710 ENOG4105CTJ Metal Dependent Phosphohydrolase HR084_RS12715 ENOG4105C9A Phoh family HR084_RS12720 ENOG4105EI1 sporulation protein yqfd HR084_RS12725 ENOG41068P3 sporulation protein YqfC HR084_RS12735 ENOG4105DI5 UPF0365 protein HR084_RS12740 ENOG4105F7J membrane-bound serine protease HR084_RS12745 ENOG4105KTH gatB Yqey HR084_RS12760 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HR084_RS12765 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HR084_RS12770 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HR084_RS12780 ENOG4105CFG Acts as a chaperone (By similarity) HR084_RS12785 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HR084_RS12790 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HR084_RS12795 ENOG4105CSA Coproporphyrinogen iii oxidase HR084_RS12800 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HR084_RS12810 ENOG4108ZRV stage ii sporulation protein p HR084_RS12815 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HR084_RS12820 ENOG41082YS Binds directly to 16S ribosomal RNA HR084_RS12825 ENOG4105TQK DNA polymerase iii, delta' subunit HR084_RS12840 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HR084_RS12845 ENOG4108UK2 deaminase HR084_RS12850 ENOG4105KQC Competence protein HR084_RS12860 ENOG4108D32 Methyltransferase HR084_RS12870 ENOG4108WF2 Metal Dependent Phosphohydrolase HR084_RS12875 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HR084_RS12880 ENOG410812S Rna-binding protein HR084_RS12885 ENOG4105E2X shikimate dehydrogenase HR084_RS12890 ENOG4105CQW ribosome biogenesis GTPase YqeH HR084_RS12895 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HR084_RS12910 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HR084_RS12915 ENOG41080BT SNARE associated Golgi HR084_RS12930 ENOG4105WFK nuclease HR084_RS12940 ENOG4107Y5K Resolvase HR084_RS12945 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HR084_RS12960 ENOG4108IXY short-chain dehydrogenase reductase HR084_RS12965 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HR084_RS12970 ENOG4107TTQ Alpha beta hydrolase fold HR084_RS12975 ENOG4105M4P Tetr family transcriptional regulator HR084_RS12985 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HR084_RS12990 ENOG4105C7Z Conserved Protein HR084_RS12995 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HR084_RS13000 ENOG41085FC arsR family transcriptional regulator HR084_RS13120 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HR084_RS13135 ENOG4108SWU Histidine kinase HR084_RS13140 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HR084_RS13145 ENOG4105DHF Membrane HR084_RS13155 ENOG4108UYN gCN5-related N-acetyltransferase HR084_RS13160 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HR084_RS13165 ENOG41068VA HR084_RS13170 ENOG41087NI Sulfite exporter TauE/SafE HR084_RS13175 ENOG4105VFE sira family HR084_RS13180 ENOG4107TPS domain protein HR084_RS13190 ENOG4105VFE sira family HR084_RS13200 ENOG4105XTG Pfam:DUF156 HR084_RS13205 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein HR084_RS13215 ENOG41090E6 transcriptional regulator MERR family HR084_RS13230 ENOG4105C37 (CBS) domain HR084_RS13245 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HR084_RS13250 ENOG4105H3G oxidoreductase HR084_RS13255 ENOG4105PGM cation diffusion facilitator family transporter HR084_RS13260 ENOG41090U3 tautomerase HR084_RS13280 ENOG4105KMT branched-chain amino acid HR084_RS13285 ENOG4108UMN azlc family HR084_RS13290 ENOG4108ZRZ Transcriptional regulator (AsnC family) HR084_RS13295 ENOG41067XF inhibitor HR084_RS13310 ENOG41064BW Protein of unknown function (DUF2568) HR084_RS13325 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HR084_RS13330 ENOG4105EA8 2-Nitropropane dioxygenase HR084_RS13335 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HR084_RS13355 ENOG4108MEK Metal-binding protein YodA HR084_RS13360 ENOG410904A RNA polymerase HR084_RS13365 ENOG4105CPC Aldo Keto reductase HR084_RS13375 ENOG4108KAM Transcriptional regulator HR084_RS13380 ENOG4105C7F AcnD-accessory protein PrpF HR084_RS13385 ENOG41083Q9 chitosanase HR084_RS13390 ENOG4105X5K response regulator receiver protein HR084_RS13395 ENOG4108VQT Alpha beta hydrolase fold protein HR084_RS13400 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HR084_RS13405 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HR084_RS13410 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase HR084_RS13420 ENOG4105PGS Spore coat protein HR084_RS13425 ENOG4105E2A Dehydrogenase HR084_RS13440 ENOG4105VUF Transcriptional regulator HR084_RS13450 ENOG4105DQ4 alcohol dehydrogenase HR084_RS13455 ENOG4108Z0Z intracellular protease Pfpi family HR084_RS13460 ENOG4108HKT sucrose-6-phosphate hydrolase HR084_RS13465 ENOG4105F3R pts system mannose fructose sorbose family iid HR084_RS13470 ENOG4105ETZ PTS System HR084_RS13475 ENOG4108IQ3 PTS system HR084_RS13480 ENOG4105YHU PTS system HR084_RS13485 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HR084_RS13495 ENOG4105C85 amino acid HR084_RS13500 ENOG4105N14 lysine exporter protein LysE YggA HR084_RS13505 ENOG4108NGU Transcriptional regulator HR084_RS13510 ENOG4105JVQ RNA Polymerase HR084_RS13515 ENOG4108P49 AntiSigma factor HR084_RS13520 ENOG4105EXC Acyl-transferase HR084_RS13525 ENOG4105WDR HR084_RS13530 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HR084_RS13535 ENOG41082JN Transcriptional regulator HR084_RS13555 ENOG4105TMB Formate nitrite transporter HR084_RS13560 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HR084_RS13565 ENOG4108JB9 formate dehydrogenase HR084_RS13580 ENOG4105C28 cystathionine HR084_RS13595 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HR084_RS13610 ENOG4107XRG penicillin-binding protein HR084_RS13615 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HR084_RS13620 ENOG4105DBI uridine monophosphokinase HR084_RS13625 ENOG4105CFP Peptidase U32 HR084_RS13630 ENOG4105XYU peptidase (U32 family) HR084_RS13640 ENOG4105HHA aminodeoxychorismate lyase HR084_RS13645 ENOG4105VPH UPF0473 protein HR084_RS13650 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HR084_RS13655 ENOG4105VBH UPF0297 protein HR084_RS13660 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HR084_RS13665 ENOG4105C02 permease HR084_RS13670 ENOG4105CDA abc transporter atp-binding protein HR084_RS13675 ENOG4105CT1 (ABC) transporter HR084_RS13680 ENOG4105EAD ABC transporter HR084_RS13685 ENOG4105DRP amino acid AbC transporter HR084_RS13695 ENOG41060CR HR084_RS13705 ENOG4105C7H Helicase, RecD TraA family HR084_RS13715 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HR084_RS13720 ENOG4105C3J Cysteine desulfurase HR084_RS13730 ENOG4105D1H recombination factor protein RarA HR084_RS13735 ENOG4105CUZ uba thif-type nad fad binding protein HR084_RS13745 ENOG4105C9M aspartyl-trna synthetase HR084_RS13750 ENOG4105CUT histidyl-tRNA synthetase HR084_RS13760 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HR084_RS13770 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HR084_RS13775 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HR084_RS13780 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HR084_RS13785 ENOG41067VP Protein of unknown function (DUF1049) HR084_RS13790 ENOG4105NCW Trka-c domain protein HR084_RS13795 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HR084_RS13805 ENOG4105CKP Polysaccharide Biosynthesis Protein HR084_RS13810 ENOG4108QG2 Membrane HR084_RS13815 ENOG4105NAP HR084_RS13820 ENOG4105VIE preprotein translocase, subunit YajC HR084_RS13825 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HR084_RS13830 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HR084_RS13835 ENOG41061AI Protein of unknown function (DUF2905) HR084_RS13840 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HR084_RS13845 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HR084_RS13855 ENOG4105IE8 Alpha-ketoglutarate permease HR084_RS13860 ENOG4105CK5 oxidoreductase HR084_RS13885 ENOG4105BZG amino acid carrier protein HR084_RS13890 ENOG4105CDY transcriptional regulatory protein HR084_RS13900 ENOG4106678 morphogenetic protein associated with SpoVID HR084_RS13905 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HR084_RS13910 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HR084_RS13915 ENOG4108IYU L-aspartate oxidase HR084_RS13930 ENOG4105CQC Prephenate dehydratase HR084_RS13935 ENOG41090I5 UPF0735 ACT domain-containing protein HR084_RS13940 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HR084_RS13955 ENOG4105K46 50S ribosomal protein l27 HR084_RS13960 ENOG4105X36 (ribosomal) protein HR084_RS13965 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HR084_RS13980 ENOG4107QMS site-determining protein HR084_RS13985 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HR084_RS13990 ENOG4105YHC Rod shape-determining protein MreD HR084_RS14000 ENOG4105DFF Rod shape-determining protein mreb HR084_RS14005 ENOG4105W5Q DNA repair protein (RadC HR084_RS14010 ENOG4108Z03 MAF-like protein HR084_RS14020 ENOG4106A3R peptidase HR084_RS14025 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HR084_RS14030 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HR084_RS14040 ENOG4106AR7 Spore coat protein HR084_RS14045 ENOG41068KH stage VI sporulation protein D HR084_RS14050 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HR084_RS14055 ENOG4105D52 delta-aminolevulinic acid dehydratase HR084_RS14065 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HR084_RS14075 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HR084_RS14085 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HR084_RS14090 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HR084_RS14095 ENOG4108IUQ atp-dependent protease HR084_RS14100 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HR084_RS14105 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HR084_RS14115 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HR084_RS14120 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HR084_RS14125 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HR084_RS14130 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HR084_RS14135 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HR084_RS14140 ENOG4108ZP8 Acetolactate synthase small subunit HR084_RS14145 ENOG4105C7K acetolactate synthase HR084_RS14155 ENOG4105I4A GCN5-related N-acetyltransferase HR084_RS14160 ENOG4107KM7 Heat induced stress protein YflT HR084_RS14170 ENOG4105M59 Phosphodiesterase, mj0936 family HR084_RS14175 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HR084_RS14180 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HR084_RS14185 ENOG4108XJQ germination protein HR084_RS14190 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HR084_RS14195 ENOG41067TZ transcriptional regulator, MarR family HR084_RS14200 ENOG4105PFC Transcriptional regulator HR084_RS14210 ENOG4105E33 succinate dehydrogenase HR084_RS14220 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HR084_RS14230 ENOG4105CFH Aspartokinase HR084_RS14235 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HR084_RS14240 ENOG4105K63 Thioredoxin HR084_RS14245 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HR084_RS14250 ENOG4105C10 Electron transfer flavoprotein HR084_RS14255 ENOG4105BZJ Electron transfer flavoprotein HR084_RS14260 ENOG41060WC Enoyl-CoA hydratase HR084_RS14265 ENOG4107Z3H Transcriptional regulator, TetR family HR084_RS14270 ENOG4105CEY Amp-dependent synthetase and ligase HR084_RS14280 ENOG4105C98 muts2 protein HR084_RS14285 ENOG4105DCG PHP domain protein HR084_RS14300 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HR084_RS14305 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HR084_RS14310 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HR084_RS14320 ENOG4108RWN rrna methyltransferase HR084_RS14325 ENOG41067MF small acid-soluble spore protein HR084_RS14335 ENOG4105CQB FAD linked oxidase domain protein HR084_RS14340 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HR084_RS14355 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HR084_RS14360 ENOG4105DRS transport system, permease HR084_RS14375 ENOG4108MDK Dehydrogenase HR084_RS14385 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HR084_RS14390 ENOG4105EF1 ribulokinase HR084_RS14400 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HR084_RS14405 ENOG4105CN9 Peptidase m42 family protein HR084_RS14415 ENOG410696E Membrane HR084_RS14420 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HR084_RS14425 ENOG4105VJV 50s ribosomal protein L35 HR084_RS14430 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HR084_RS14440 ENOG41067MG lrgb family HR084_RS14450 ENOG4105DY9 regulatoR HR084_RS14455 ENOG4108HRK Histidine kinase HR084_RS14465 ENOG4105C22 threonyL-tRNA synthetase HR084_RS14470 ENOG4108TDW sporulation protein YtxC HR084_RS14490 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HR084_RS14495 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HR084_RS14500 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HR084_RS14505 ENOG4105KVH Transcriptional regulator HR084_RS14510 ENOG4105F27 Major Facilitator HR084_RS14515 ENOG4105CV8 reductase HR084_RS14520 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HR084_RS14530 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HR084_RS14535 ENOG4105C2M dna polymerase I HR084_RS14540 ENOG4105BZU Histidine kinase HR084_RS14545 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HR084_RS14550 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HR084_RS14555 ENOG4108HMX isocitrate dehydrogenase (NADP) HR084_RS14560 ENOG4105BZN citrate synthase HR084_RS14570 ENOG4108REF Sporulation integral membrane protein ytvi HR084_RS14575 ENOG4105FS0 cytoplasmic membrane protein HR084_RS14580 ENOG4105CA9 Pyruvate kinase HR084_RS14585 ENOG4105CTQ phosphohexokinase HR084_RS14595 ENOG4108IEY Carboxyl transferase domain HR084_RS14600 ENOG4105C6K Malic enzyme HR084_RS14605 ENOG4105C0B DNA polymerase III (alpha subunit) HR084_RS14610 ENOG4105VV2 HR084_RS14620 ENOG4106EVM HR084_RS14625 ENOG4105SFS phosphoesterase RecJ domain protein HR084_RS14640 ENOG410635A Membrane HR084_RS14645 ENOG4105CH2 amidohydrolase HR084_RS14665 ENOG4105DEN Luciferase family HR084_RS14670 ENOG4105CDA abc transporter atp-binding protein HR084_RS14695 ENOG4108XSB acetyltransferase, (GNAT) family HR084_RS14700 ENOG4108KSA LysR family transcriptional regulator HR084_RS14705 ENOG4105E8R UPF0173 metal-dependent hydrolase HR084_RS14715 ENOG4105CH7 arginosuccinase HR084_RS14720 ENOG4105CDH Citrulline--aspartate ligase HR084_RS14725 ENOG4105EPU Molybdenum cofactor synthesis domain protein HR084_RS14730 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HR084_RS14745 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HR084_RS14750 ENOG4105KBJ sporulation protein ytfj HR084_RS14760 ENOG4105VK3 rdd domain containing protein HR084_RS14765 ENOG4105D07 Signal peptide peptidase, SppA HR084_RS14770 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HR084_RS14775 ENOG4105EFZ amidohydrolase HR084_RS14780 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HR084_RS14815 ENOG4105U5Y Transcriptional regulator HR084_RS14825 ENOG4105BZU Histidine kinase HR084_RS14830 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HR084_RS14835 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HR084_RS14845 ENOG4105F1V Acetoin utilization protein HR084_RS14850 ENOG4105W87 Cbs domain HR084_RS14855 ENOG4105DGU Histone deacetylase HR084_RS14860 ENOG4105ER2 Ompa motb domain protein HR084_RS14865 ENOG4107R0U MotA TolQ exbB proton channel HR084_RS14870 ENOG4105ETE Transcriptional regulator (LacI family HR084_RS14875 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HR084_RS14895 ENOG4105DFU Cell wall formation (By similarity) HR084_RS14905 ENOG4108VDD TRNA binding domain protein HR084_RS14925 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HR084_RS14940 ENOG4105C6K Malic enzyme HR084_RS14945 ENOG4105C8F Beta-lactamase domain protein HR084_RS14950 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HR084_RS14960 ENOG4108V15 phosphotransferase enzyme family HR084_RS14965 ENOG4108IUM Glycogen debranching enzyme HR084_RS14980 ENOG4107F58 2'-5' rna ligase HR084_RS14985 ENOG4105C6T cysteine synthase HR084_RS14990 ENOG4107QSE Dipeptidase HR084_RS14995 ENOG4105C7N Xanthine uracil vitamin C permease HR084_RS15010 ENOG4105YW5 deoR family transcriptional regulator HR084_RS15025 ENOG4105CBX hi0933 family HR084_RS15030 ENOG4105C94 Transporter HR084_RS15040 ENOG4105MU9 integral membrane protein HR084_RS15045 ENOG4105DDC Oxidoreductase domain protein HR084_RS15055 ENOG4105F5H Glycosyl Hydrolase Family 88 HR084_RS15065 ENOG41075H3 AraC family transcriptional regulator HR084_RS15075 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HR084_RS15085 ENOG4106A3M Cytochrome p-450 HR084_RS15090 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HR084_RS15100 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HR084_RS15105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HR084_RS15110 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) HR084_RS15115 ENOG4105NTD Inherit from COG: Hydrolase HR084_RS15145 ENOG41085GJ domain protein HR084_RS15150 ENOG4105C8T Leucyl-tRNA synthetase HR084_RS15160 ENOG4105BZU Histidine kinase HR084_RS15165 ENOG410605W Major Facilitator HR084_RS15170 ENOG4106UBQ HR084_RS15180 ENOG4105C19 ABC transporter HR084_RS15185 ENOG4105EWM Histidine kinase HR084_RS15195 ENOG4107R34 abc transporter permease protein HR084_RS15200 ENOG4105C19 ABC transporter HR084_RS15215 ENOG4105DVE abc transporter atp-binding protein HR084_RS15220 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HR084_RS15235 ENOG4105N5T Radical SAM Protein HR084_RS15250 ENOG4105E8V Alpha Beta Hydrolase Fold protein HR084_RS15255 ENOG4108Z0R Transferase HR084_RS15260 ENOG4105C85 amino acid HR084_RS15265 ENOG4105CAQ asparagine synthetase HR084_RS15270 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HR084_RS15275 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HR084_RS15290 ENOG4105D2X ABC transporter substrate-binding protein HR084_RS15300 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HR084_RS15315 ENOG4108RMU ferritin dps family protein HR084_RS15330 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HR084_RS15335 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HR084_RS15340 ENOG4108V2W Carbonate dehydratase HR084_RS15365 ENOG4105CC5 ABC transporter HR084_RS15370 ENOG4105CC5 ABC transporter HR084_RS15375 ENOG4105DIK (ABC) transporter HR084_RS15380 ENOG4105DSE periplasmic solute binding protein HR084_RS15385 ENOG4105DTQ mandelate racemase muconate lactonizing HR084_RS15390 ENOG4105CEY Amp-dependent synthetase and ligase HR084_RS15395 ENOG4108IPT Naphthoate synthase HR084_RS15400 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HR084_RS15405 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HR084_RS15410 ENOG4105E4F Isochorismate synthase HR084_RS15430 ENOG4108IAJ Nad-dependent epimerase dehydratase HR084_RS15435 ENOG4107SBE Glycosyl transferase (Group 1 HR084_RS15450 ENOG4107SBE Glycosyl transferase (Group 1 HR084_RS15455 ENOG4108KS4 Spore coat protein HR084_RS15470 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HR084_RS15480 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HR084_RS15610 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HR084_RS15615 ENOG4105VRR gCN5-related N-acetyltransferase HR084_RS15620 ENOG4105DZ6 Band 7 protein HR084_RS15630 ENOG4106DF1 HR084_RS15635 ENOG4108VNY MOSC domain protein HR084_RS15640 ENOG4108JB8 alcohol dehydrogenase HR084_RS15650 ENOG4105TRT Transcriptional regulator HR084_RS15665 ENOG4105CZN Potassium uptake protein HR084_RS15670 ENOG4107I77 yiaA/B two helix domain HR084_RS15675 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HR084_RS15695 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HR084_RS15705 ENOG4105EE0 oxidoreductase HR084_RS15710 ENOG4105DKG l-rhamnose isomerase HR084_RS15715 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HR084_RS15720 ENOG4105DET Rhamnulokinase HR084_RS15725 ENOG4105E98 transcriptional regulator DeoR family HR084_RS15735 ENOG4105C8Q Methyl-accepting chemotaxis HR084_RS15740 ENOG4105C8Q Methyl-accepting chemotaxis HR084_RS15745 ENOG4105C8Q Methyl-accepting chemotaxis HR084_RS15750 ENOG4105C8Q Methyl-accepting chemotaxis HR084_RS15765 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HR084_RS15780 ENOG4105C37 (CBS) domain HR084_RS15795 ENOG4107PBV potassium channel HR084_RS15800 ENOG4107PBV potassium channel HR084_RS15815 ENOG4107QYV phosphohexose isomerase HR084_RS15825 ENOG4107QW4 alcohol dehydrogenase HR084_RS15830 ENOG4105WG9 Conserved Protein HR084_RS15840 ENOG4105CHM Aminotransferase HR084_RS15845 ENOG4108ZB6 transcriptional regulator AsnC family HR084_RS15850 ENOG4108MUZ hydrolase HR084_RS15860 ENOG4105C87 Aminotransferase class I and II HR084_RS15865 ENOG4108HGU Histidine kinase HR084_RS15870 ENOG4105Y38 Kinase-associated protein B HR084_RS15885 ENOG4105BZ4 penicillin-binding protein HR084_RS15890 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HR084_RS15905 ENOG4108MRH transcriptional regulatory protein HR084_RS15910 ENOG4105DIH basic membrane HR084_RS15915 ENOG4108JQ9 ABC transporter HR084_RS15920 ENOG4105UIB (ABC) transporter HR084_RS15940 ENOG4105D65 subunit l HR084_RS15945 ENOG4105HC0 Na H antiporter HR084_RS15950 ENOG4108ZE9 Monovalent cation H antiporter subunit C HR084_RS15955 ENOG4108JPZ Monovalent cation H antiporter subunit D HR084_RS15960 ENOG4105SC1 monovalent cation H antiporter subunit E HR084_RS15970 ENOG4105KJM monovalent cation h antiporter subunit g HR084_RS15975 ENOG4105KA0 thioesterase Superfamily protein HR084_RS16015 ENOG4105D58 Diguanylate phosphodiesterase HR084_RS16020 ENOG4105DAP Nicotinate phosphoribosyltransferase HR084_RS16045 ENOG4105C02 permease HR084_RS16065 ENOG410904N short-chain dehydrogenase reductase HR084_RS16100 ENOG4108K8K Transcriptional regulator HR084_RS16105 ENOG4105DCF alanine dehydrogenase HR084_RS16115 ENOG4105WQT MbtH domain protein HR084_RS16120 ENOG4105CEY Amp-dependent synthetase and ligase HR084_RS16125 ENOG4105WQI isochorismatase HR084_RS16130 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HR084_RS16135 ENOG4105E4F Isochorismate synthase HR084_RS16140 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HR084_RS16145 ENOG4105NIV Esterase HR084_RS16165 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HR084_RS16175 ENOG41069ER domain protein HR084_RS16190 ENOG4105CEP NADH dehydrogenase HR084_RS16195 ENOG4105CAY ferredoxin--nadp reductase HR084_RS16215 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HR084_RS16220 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HR084_RS16235 ENOG4105ZKE UPF0349 protein HR084_RS16250 ENOG41083MR nifu domain-containing protein HR084_RS16255 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HR084_RS16260 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HR084_RS16265 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HR084_RS16270 ENOG4105D6E homoserine dehydrogenase HR084_RS16280 ENOG4108W5N phosphatidylglycerophosphatase a HR084_RS16285 ENOG4105D4U had-superfamily hydrolase, subfamily iia HR084_RS16295 ENOG4105MMD transcriptional regulator HR084_RS16300 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HR084_RS16305 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HR084_RS16310 ENOG4105FAA peptidase M23 HR084_RS16315 ENOG4108YTE sporulation protein YunB HR084_RS16320 ENOG4105KZD Domain of unknown function (DUF1805) HR084_RS16325 ENOG4107R8B 5'-nucleotidase HR084_RS16335 ENOG4105I3N Conserved Protein HR084_RS16345 ENOG4105CD3 dihydroorotase HR084_RS16350 ENOG4105G9B Transcriptional regulator HR084_RS16365 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HR084_RS16370 ENOG4105VT2 5-hydroxyisourate hydrolase HR084_RS16380 ENOG4107YV9 domain protein HR084_RS16385 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HR084_RS16400 ENOG4105XRQ Xanthine dehydrogenase accessory factor HR084_RS16405 ENOG4105C5R Aminotransferase HR084_RS16420 ENOG4108K8S endonuclease I HR084_RS16425 ENOG4108IJ9 (ABC) transporter HR084_RS16430 ENOG4105FDP GntR family transcriptional regulator HR084_RS16435 ENOG4108KPW sugar kinase HR084_RS16440 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HR084_RS16445 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HR084_RS16450 ENOG4105XN3 extracellular solute-binding protein family 1 HR084_RS16455 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HR084_RS16460 ENOG4105PKS Excinuclease abc c subunit domain protein HR084_RS16465 ENOG4107VFR oxidoreductase HR084_RS16480 ENOG4105DIW FeS assembly protein SUFB HR084_RS16485 ENOG4108UNV SUF system FeS assembly protein, NifU family HR084_RS16490 ENOG4105C9B Cysteine desulfurase HR084_RS16495 ENOG4105JRK feS assembly protein SufD HR084_RS16500 ENOG4105C3K feS assembly ATPase SufC HR084_RS16515 ENOG4105D01 (LipO)protein HR084_RS16520 ENOG4108UMI ABC transporter, permease HR084_RS16525 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HR084_RS16550 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HR084_RS16555 ENOG41080E8 Transcriptional regulator, Spx MgsR family HR084_RS16560 ENOG4105C1G acyl-Coa dehydrogenase HR084_RS16565 ENOG4105CHU acetyl-coa acetyltransferase HR084_RS16595 ENOG41067TZ transcriptional regulator, MarR family HR084_RS16600 ENOG4105C0R drug resistance transporter emrb qaca subfamily HR084_RS16605 ENOG4105MDS 4-oxalocrotonate tautomerase HR084_RS16615 ENOG4105EGI Transcriptional regulator HR084_RS16625 ENOG4105E0A ABC, transporter HR084_RS16640 ENOG4105E1F short-chain dehydrogenase reductase HR084_RS16645 ENOG4105HUF DNA protection during starvation protein HR084_RS16650 ENOG4105C0H protease HR084_RS16660 ENOG4105F3H Histidine kinase HR084_RS16670 ENOG41067SE Tetr family transcriptional regulator HR084_RS16675 ENOG4105C9Q fumarate hydratase class II HR084_RS16700 ENOG4105WH1 Two component transcriptional regulator luxr family HR084_RS16705 ENOG4105ENE Histidine kinase HR084_RS16720 ENOG41087YS Phage shock protein A HR084_RS16735 ENOG4108WBT adenosyltransferase HR084_RS16740 ENOG4105E0A ABC, transporter HR084_RS16745 ENOG4105EHG Permease protein HR084_RS16750 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HR084_RS16755 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HR084_RS16760 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HR084_RS16770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HR084_RS16780 ENOG4106DF4 Sigma-70, region 4 HR084_RS16790 ENOG4105F0F Oxalate decarboxylase HR084_RS16800 ENOG4107RBB ABC transporter, permease HR084_RS16805 ENOG4105C19 ABC transporter HR084_RS16810 ENOG4108WMK Efflux transporter RND family MFP subunit HR084_RS16815 ENOG4105E0A ABC, transporter HR084_RS16820 ENOG4105EHG Permease protein HR084_RS16825 ENOG4105DQ5 transport system permease protein HR084_RS16835 ENOG4105D5Q Arginine ornithine antiporter HR084_RS16845 ENOG4107K5X Membrane-bound metal-dependent hydrolase HR084_RS16850 ENOG4107QZ2 Sulfatase HR084_RS16855 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HR084_RS16860 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HR084_RS16865 ENOG4105E0C molybdate abc transporter HR084_RS16880 ENOG4105EEQ Na H antiporter HR084_RS16885 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HR084_RS16890 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HR084_RS16895 ENOG4105EEM helicase HR084_RS16900 ENOG4105EN6 Membrane HR084_RS16910 ENOG4107ZQN disulfide bond HR084_RS16915 ENOG4105C59 p-type ATPase HR084_RS16920 ENOG4105C59 p-type ATPase HR084_RS16925 ENOG410681U heavy metal transport detoxification protein HR084_RS16930 ENOG4105VPX protein, conserved in bacteria HR084_RS16935 ENOG4105D9R oxidoreductase HR084_RS16940 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HR084_RS16945 ENOG4105ME7 Membrane HR084_RS16950 ENOG4105RXJ HR084_RS16955 ENOG4105KPY Small multidrug resistance protein HR084_RS16960 ENOG4105KBX Transcriptional regulator, TetR family HR084_RS16965 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HR084_RS16975 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HR084_RS16980 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HR084_RS16990 ENOG4105XZU Preprotein translocase, subunit SecG HR084_RS17015 ENOG4105KVH Transcriptional regulator HR084_RS17020 ENOG4105C8Q Methyl-accepting chemotaxis HR084_RS17025 ENOG4105R40 Glycine betaine carnitine choline HR084_RS17030 ENOG4108HQR Glycine betaine HR084_RS17035 ENOG4105E90 ABC transporter HR084_RS17040 ENOG4108IJ8 ABC transporter HR084_RS17045 ENOG4107HG4 Transcriptional regulator HR084_RS17050 ENOG4105R40 Glycine betaine carnitine choline HR084_RS17055 ENOG4108HQR Glycine betaine HR084_RS17060 ENOG4105E90 ABC transporter HR084_RS17065 ENOG4108IJ8 ABC transporter HR084_RS17070 ENOG4107HG4 Transcriptional regulator HR084_RS17075 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HR084_RS17080 ENOG4108QCI YvbH-like oligomerisation region HR084_RS17090 ENOG4105T65 Membrane-associated protein HR084_RS17095 ENOG4108W0I acetyltransferase HR084_RS17100 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HR084_RS17105 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HR084_RS17110 ENOG4105CP7 Triose-phosphate isomerase HR084_RS17115 ENOG4105BZA Phosphoglycerate kinase HR084_RS17120 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HR084_RS17135 ENOG4105CMD Transcriptional regulator, GntR family HR084_RS17140 ENOG4105DEN Luciferase family HR084_RS17145 ENOG4105GZI Transcriptional regulator HR084_RS17150 ENOG4107RT3 EamA-like transporter family HR084_RS17160 ENOG4105VRS hydrolase family 18 HR084_RS17165 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HR084_RS17170 ENOG4107QR9 Iron-sulfur cluster binding protein HR084_RS17175 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HR084_RS17185 ENOG4105BZU Histidine kinase HR084_RS17190 ENOG4105KCT ABC transporter HR084_RS17195 ENOG4108M15 ABC transporter HR084_RS17200 ENOG4107R6F Alpha Beta Hydrolase Fold protein HR084_RS17205 ENOG4108MJI response regulator HR084_RS17220 ENOG4105EG2 ABC transporter, permease HR084_RS17230 ENOG4107FKK extracellular solute-binding protein family 1 HR084_RS17240 ENOG4105JXH GntR family transcriptional regulator HR084_RS17245 ENOG4105DAA L-lactate HR084_RS17250 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HR084_RS17260 ENOG4108ZPC Polysaccharide pyruvyl transferase HR084_RS17265 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HR084_RS17270 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HR084_RS17275 ENOG4105D3Q Sugar transferase HR084_RS17285 ENOG4105K64 Glycosyl transferase, family 2 HR084_RS17295 ENOG4107QRS glycosyltransferase group 2 family protein HR084_RS17300 ENOG41068W6 Capsular polysaccharide biosynthesis protein HR084_RS17305 ENOG4108KMV Glycosyl transferase (Group 1 HR084_RS17310 ENOG4105K64 Glycosyl transferase, family 2 HR084_RS17315 ENOG4108PQP glycosyl transferase group 1 HR084_RS17325 ENOG4108QV3 biosynthesis protein HR084_RS17330 ENOG4105HTX biosynthesis protein HR084_RS17340 ENOG4105EBR Carboxylesterase HR084_RS17350 ENOG4105PY6 Phenolic acid decarboxylase HR084_RS17355 ENOG4105NI3 Protein of unknown function (DUF3237) HR084_RS17365 ENOG4105FQP Beta-lactamase HR084_RS17370 ENOG4105EDQ levansucrase EC 2.4.1.10 HR084_RS17375 ENOG4108HKT sucrose-6-phosphate hydrolase HR084_RS17380 ENOG4107QTZ amino acid HR084_RS17405 ENOG4105DNP FAD linked oxidase domain protein HR084_RS17410 ENOG4105IRW patatin-like phospholipase family protein HR084_RS17420 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HR084_RS17425 ENOG4107URF beta-phospho-glucomutase HR084_RS17430 ENOG4105CG3 alpha amylase, catalytic region HR084_RS17445 ENOG4105EG2 ABC transporter, permease HR084_RS17450 ENOG4105D56 permease protein HR084_RS17455 ENOG4107FKK extracellular solute-binding protein family 1 HR084_RS17460 ENOG4108IUK alpha amylase, catalytic HR084_RS17465 ENOG4105FKQ transcriptional regulator HR084_RS17470 ENOG4108URH decarboxylase HR084_RS17475 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HR084_RS17480 ENOG4105CHH sulfate transporter HR084_RS17485 ENOG4108V2W Carbonate dehydratase HR084_RS17490 ENOG4105C5I Dehydrogenase HR084_RS17500 ENOG4105C19 ABC transporter HR084_RS17505 ENOG4105EWM Histidine kinase HR084_RS17515 ENOG4107A6P HR084_RS17520 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HR084_RS17525 ENOG4105KRI phosphocarrier protein (HPr HR084_RS17530 ENOG4105CIE May be required for sporulation (By similarity) HR084_RS17535 ENOG4105CHW UPF0052 protein HR084_RS17540 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HR084_RS17545 ENOG4108Z4K mutator MutT protein HR084_RS17550 ENOG4105C3M thioredoxin reductase HR084_RS17565 ENOG4105BZ1 (ABC) transporter HR084_RS17575 ENOG4106FGC HR084_RS17585 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HR084_RS17590 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HR084_RS17595 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HR084_RS17600 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HR084_RS17605 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HR084_RS17610 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HR084_RS17615 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HR084_RS17620 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HR084_RS17630 ENOG4108E16 pectate lyase HR084_RS17635 ENOG4108S4C acetyltransferase HR084_RS17640 ENOG4107XGZ Hydrolase HR084_RS17645 ENOG4105HKU nucleoside recognition domain-containing protein HR084_RS17650 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HR084_RS17655 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HR084_RS17660 ENOG4105CE4 GlcNAc 6-P deacetylase HR084_RS17665 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HR084_RS17675 ENOG41088CQ domain protein HR084_RS17685 ENOG4106A3M Cytochrome p-450 HR084_RS17690 ENOG410625E HR084_RS17705 ENOG41086DT Membrane protein of unknown function HR084_RS17710 ENOG41067S9 phage shock protein C, PspC HR084_RS17715 ENOG4108PY7 HR084_RS17730 ENOG4105I03 Flagellin HR084_RS17735 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HR084_RS17740 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HR084_RS17755 ENOG4105MKU Transcriptional regulator HR084_RS17775 ENOG4105CN1 protease HR084_RS17780 ENOG4105CRP Part of the ABC transporter FtsEX involved in HR084_RS17785 ENOG4105CAK Cell division ATP-binding protein ftsE HR084_RS17810 ENOG4105MS2 ribosomal subunit Interface protein HR084_RS17825 ENOG4105MQ3 flagellar protein FliS HR084_RS17830 ENOG4107RT6 flagellar hook-associated HR084_RS17835 ENOG41083S7 flagellar protein FlaG HR084_RS17840 ENOG4105I03 Flagellin HR084_RS17845 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HR084_RS17850 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HR084_RS17855 ENOG4105MKD HR084_RS17860 ENOG4105DTJ flagellar hook-associated protein HR084_RS17865 ENOG4105E1Q flagellar hook-associated protein HR084_RS17880 ENOG4105RU3 HR084_RS17885 ENOG41081UC Inherit from COG: Competence protein HR084_RS17905 ENOG4105WH1 Two component transcriptional regulator luxr family HR084_RS17910 ENOG4105BZU Histidine kinase HR084_RS17915 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HR084_RS17920 ENOG4108KGH TRANSCRIPTIONal HR084_RS17925 ENOG4105ESV Glycosyl transferase, family 4 HR084_RS17930 ENOG4107EF8 Glycosyl transferase (Group 1 HR084_RS17945 ENOG4105QZI O-Antigen Polymerase HR084_RS17950 ENOG4105C6Y Udp-glucose 6-dehydrogenase HR084_RS17955 ENOG4107RA4 Glycosyl transferase (Group 1 HR084_RS17960 ENOG4105PSV Polysaccharide Biosynthesis Protein HR084_RS17965 ENOG4105D3Q Sugar transferase HR084_RS17975 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HR084_RS17980 ENOG4105JFG SpoIID LytB domain protein HR084_RS17995 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HR084_RS18015 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HR084_RS18020 ENOG4105EY8 ABC transporter HR084_RS18040 ENOG4107VDP teichoic acid biosynthesis HR084_RS18045 ENOG41088M2 Glycosyl transferase family 2 HR084_RS18095 ENOG4105DG6 mannose-6-phosphate isomerase HR084_RS18110 ENOG4108NHD germination protein HR084_RS18115 ENOG4105C54 Major Facilitator superfamily HR084_RS18120 ENOG4108KGH TRANSCRIPTIONal HR084_RS18125 ENOG4105J7I hydrolase HR084_RS18130 ENOG4105K4H Nlp p60 protein HR084_RS18140 ENOG4105PNM synthesis protein HR084_RS18150 ENOG4105N98 Capsule biosynthesis protein capB HR084_RS18155 ENOG4105ETE Transcriptional regulator (LacI family HR084_RS18160 ENOG4108RVA ribokinase HR084_RS18165 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HR084_RS18170 ENOG4105C2J ABC transporter HR084_RS18175 ENOG4105CNN ABC, transporter HR084_RS18180 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HR084_RS18195 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HR084_RS18200 ENOG4107FQX Alpha-acetolactate decarboxylase HR084_RS18210 ENOG4107RSM transcriptional regulator HR084_RS18225 ENOG4106UIA HR084_RS18240 ENOG4107XC4 flavin reductase domain protein, FMN-binding HR084_RS18250 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HR084_RS18260 ENOG4105CAH Chromate HR084_RS18265 ENOG4105FGV Chromate HR084_RS18275 ENOG4108WS4 fmn reductase HR084_RS18280 ENOG4107V2S Transcriptional regulator HR084_RS18285 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HR084_RS18330 ENOG4108XI2 Domain of unknown function (DUF1963) HR084_RS18335 ENOG4105C6Y Udp-glucose 6-dehydrogenase HR084_RS18340 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HR084_RS18345 ENOG4107YJ4 chain length determinant protein HR084_RS18350 ENOG4105HTX biosynthesis protein HR084_RS18360 ENOG4105KBK Zinc finger, swim domain protein HR084_RS18365 ENOG4105C0D helicase HR084_RS18370 ENOG410667J hydrolase HR084_RS18375 ENOG4105E98 transcriptional regulator DeoR family HR084_RS18380 ENOG4105Z8H single-stranded DNA-binding protein HR084_RS18410 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HR084_RS18415 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HR084_RS18425 ENOG4105CGA flagellar basal-body rod protein FlgG HR084_RS18435 ENOG4105DFF Rod shape-determining protein mreb HR084_RS18440 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HR084_RS18450 ENOG4107MII Sugar-specific transcriptional regulator TrmB HR084_RS18455 ENOG4105CZM Major Facilitator HR084_RS18460 ENOG4108M26 parallel beta-helix repeat protein HR084_RS18465 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HR084_RS18470 ENOG41080V3 Major Facilitator superfamily HR084_RS18475 ENOG4105D3W isochorismatase HR084_RS18480 ENOG4107P26 HR084_RS18485 ENOG4105BZU Histidine kinase HR084_RS18495 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HR084_RS18505 ENOG4105FRN stage II sporulation protein HR084_RS18510 ENOG4107TCE N-acetyltransferase HR084_RS18530 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HR084_RS18535 ENOG4107TXC Transcriptional regulator HR084_RS18540 ENOG4106BRK HR084_RS18545 ENOG4108RYK Nad-dependent epimerase dehydratase HR084_RS18550 ENOG4108Z40 Transcriptional regulator HR084_RS18555 ENOG4105CQM Urea amidohydrolase subunit alpha HR084_RS18560 ENOG4105KI2 Urea amidohydrolase subunit beta HR084_RS18565 ENOG4108YZ9 Urea amidohydrolase subunit gamma HR084_RS18600 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HR084_RS18610 ENOG4108TF4 von Willebrand factor, type A HR084_RS18625 ENOG4105JFG SpoIID LytB domain protein HR084_RS18630 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HR084_RS18640 ENOG4106778 Protein of unknown function (DUF1146) HR084_RS18650 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HR084_RS18655 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HR084_RS18660 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HR084_RS18665 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HR084_RS18685 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) HR084_RS18695 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HR084_RS18700 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HR084_RS18705 ENOG4108UIC UPF0340 protein HR084_RS18710 ENOG4108YZG isomerase HR084_RS18715 ENOG4107WAU Protein tyrosine phosphatase HR084_RS18720 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HR084_RS18725 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HR084_RS18735 ENOG4108ZXQ stage ii sporulation protein r HR084_RS18750 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HR084_RS18755 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HR084_RS18760 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HR084_RS18770 ENOG4107TT2 Auxin Efflux Carrier HR084_RS18775 ENOG4105C6K Malic enzyme HR084_RS18780 ENOG4107104 thymidine kinase HR084_RS18790 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HR084_RS18800 ENOG4105CBT Fructose-1,6-bisphosphatase HR084_RS18805 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HR084_RS18810 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway HR084_RS18815 ENOG4105D2N Aldolase HR084_RS18820 ENOG410812K response regulator receiver protein HR084_RS18830 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HR084_RS18840 ENOG4105C1G acyl-Coa dehydrogenase HR084_RS18845 ENOG4105DF6 Fe-S oxidoreductase HR084_RS18855 ENOG4105E5J UV damage endonuclease HR084_RS18865 ENOG4105NAE bifunctional deaminase-reductase domain protein HR084_RS18870 ENOG4105BZ1 (ABC) transporter HR084_RS18875 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HR084_RS18890 ENOG4105R3A Nitrate reductase HR084_RS18895 ENOG4108IUE nitrate reductase beta subunit HR084_RS18915 ENOG4107V6Q Cyclic nucleotide-binding domain HR084_RS18925 ENOG4105C75 arginyL-tRNA synthetase HR084_RS18930 ENOG410684U Domain of unknown function (DUF1934) HR084_RS18945 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HR084_RS18990 ENOG4107JM4 Tetratricopeptide repeat HR084_RS19020 ENOG4108RDQ ABC transporter HR084_RS19030 ENOG4105CYW agmatinase HR084_RS19035 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HR084_RS19040 ENOG4105BZ4 penicillin-binding protein HR084_RS19045 ENOG4108XFG YwhD family HR084_RS19050 ENOG4108Z4T Peptidase M50 HR084_RS19055 ENOG41069HH 4-oxalocrotonate tautomerase HR084_RS19060 ENOG41067TZ transcriptional regulator, MarR family HR084_RS19065 ENOG4105C22 threonyL-tRNA synthetase HR084_RS19070 ENOG4105C57 major facilitator superfamily HR084_RS19075 ENOG41062ES Transcriptional regulator HR084_RS19085 ENOG4105DCI Phosphohydrolase HR084_RS19095 ENOG4108VCI transcription factor, rsfa family HR084_RS19100 ENOG4108RNG Permease of the drug metabolite transporter HR084_RS19105 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HR084_RS19110 ENOG4105DUM transcriptional regulator, lysR family HR084_RS19115 ENOG4108IJ2 phosphate acetyltransferase HR084_RS19130 ENOG4105CHM Aminotransferase HR084_RS19140 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase HR084_RS19145 ENOG4105CHR reductase HR084_RS19150 ENOG4106CHD Bacilysin biosynthesis protein bacB HR084_RS19155 ENOG41061WN bacilysin biosynthesis protein HR084_RS19160 ENOG4105FCW Major Facilitator superfamily HR084_RS19175 ENOG4105C26 Dehydrogenase HR084_RS19180 ENOG4105D82 Glutamate dehydrogenase HR084_RS19190 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HR084_RS19195 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HR084_RS19200 ENOG4105C1B dTDP-glucose 4-6-dehydratase HR084_RS19205 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HR084_RS19210 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG HR084_RS19215 ENOG4107TY6 Acylneuraminate cytidylyltransferase HR084_RS19225 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HR084_RS19230 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HR084_RS19265 ENOG4105C26 Dehydrogenase HR084_RS19270 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HR084_RS19275 ENOG4108RJ9 Glycosyl transferase, family 2 HR084_RS19295 ENOG4105DWF phosphomethylpyrimidine kinase HR084_RS19310 ENOG4105C5Y PTS System HR084_RS19315 ENOG4108QTI )-transporter HR084_RS19330 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HR084_RS19335 ENOG4105DEN Luciferase family HR084_RS19340 ENOG4108DBC nitroreductase HR084_RS19355 ENOG41060D1 Quinol oxidase HR084_RS19360 ENOG4105CCU oxidase (Subunit III) HR084_RS19365 ENOG4105BZ9 Cytochrome C oxidase, subunit I HR084_RS19370 ENOG4105E2S oxidase) subunit II HR084_RS19375 ENOG4107BMA Transglycosylase associated protein HR084_RS19385 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HR084_RS19390 ENOG4105WH5 Teichoic acid glycosylation protein HR084_RS19415 ENOG4107ZXU DSBA oxidoreductase HR084_RS19420 ENOG4105DBE peroxidase HR084_RS19425 ENOG410650H (LipO)protein HR084_RS19430 ENOG4107SJW iron permease, FTR1 HR084_RS19435 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HR084_RS19445 ENOG4105CMU LysR family (Transcriptional regulator HR084_RS19450 ENOG4105VAW lrga family HR084_RS19455 ENOG41067MG lrgb family HR084_RS19460 ENOG4105D8G Major Facilitator superfamily HR084_RS19470 ENOG4105DR4 Methyltransferase HR084_RS19480 ENOG4105CK1 PTS System HR084_RS19485 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HR084_RS19500 ENOG4105X1N Glycosyl transferase family 8 HR084_RS19510 ENOG4105GVJ transcriptional regulator HR084_RS19515 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HR084_RS19520 ENOG4105IIU Aminopeptidase HR084_RS19545 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HR084_RS19560 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HR084_RS19565 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HR084_RS19575 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HR084_RS19580 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HR084_RS19585 ENOG4105CM2 brancheD-chain amino acid aminotransferase HR084_RS19590 ENOG4105F8D glycoside hydrolase family 4 HR084_RS19595 ENOG4105VCP PTS System HR084_RS19600 ENOG4105CK1 PTS System HR084_RS19605 ENOG4105VZJ PTS System HR084_RS19610 ENOG4105EMD TRANSCRIPTIONal HR084_RS19620 ENOG4108VX5 3-methyladenine DNA glycosylase HR084_RS19625 ENOG4105CH6 catalase HR084_RS19640 ENOG4105DA5 (ABC) transporter HR084_RS19645 ENOG41069JR HR084_RS19665 ENOG4105ETS cytosine purines uracil thiamine allantoin HR084_RS19670 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HR084_RS19675 ENOG4108JJ8 (ABC) transporter HR084_RS19680 ENOG4108JJ9 ABC, transporter HR084_RS19685 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HR084_RS19690 ENOG4105C4M (Ubiquinol oxidase) subunit I HR084_RS19695 ENOG4105D2K citrate carrier protein HR084_RS19710 ENOG4107BJW polysaccharide deacetylase HR084_RS19730 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HR084_RS19740 ENOG4105CMR udp-glucose 4-epimerase HR084_RS19750 ENOG4105BZU Histidine kinase HR084_RS19755 ENOG4105WH1 Two component transcriptional regulator luxr family HR084_RS19760 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HR084_RS19785 ENOG4105DTD Dehydrogenase HR084_RS19790 ENOG4108IIH CoA-transferase subunit B HR084_RS19795 ENOG4105D6N CoA-transferase, subunit a HR084_RS19800 ENOG4105CY2 Citrate transporter HR084_RS19805 ENOG4105DHI Methyltransferase HR084_RS19825 ENOG4105CH6 catalase HR084_RS19830 ENOG4105D4T Citrate transporter HR084_RS19835 ENOG4108RZ2 Glycoside hydrolase family 16 HR084_RS19840 ENOG4105CID antiterminator HR084_RS19850 ENOG4105DEU major facilitator superfamily HR084_RS19855 ENOG4105C1J atp-dependent rna helicase HR084_RS19860 ENOG4107TDE lipolytic protein G-D-S-L family HR084_RS19920 ENOG4105CNA YD repeat protein HR084_RS19930 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HR084_RS19940 ENOG4107YZX Universal stress protein HR084_RS19945 ENOG4105CS2 ec 3.2.1.21 HR084_RS19950 ENOG4105C5Y PTS System HR084_RS19965 ENOG4107EV6 Inherit from COG: YD repeat protein HR084_RS19980 ENOG4106Z5D Glycoside Hydrolase Family 43 HR084_RS19990 ENOG4105C84 Histidine ammonia-lyase HR084_RS19995 ENOG4105CGP Urocanate hydratase HR084_RS20000 ENOG4105CI2 imidazolone-5-propionate hydrolase HR084_RS20005 ENOG4107W25 arginase agmatinase formiminoglutamase HR084_RS20015 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HR084_RS20020 ENOG4105D9N nucleoside HR084_RS20030 ENOG4107RHR regulatoR HR084_RS20035 ENOG4108TM9 integral membrane protein HR084_RS20040 ENOG4105ENY Ethanolamine utilization protein eutH HR084_RS20045 ENOG4108PGP mmge prpd family protein HR084_RS20060 ENOG4108HW4 amino acid AbC transporter HR084_RS20065 ENOG4105EAB amino acid AbC transporter HR084_RS20085 ENOG4107QHE Choloylglycine hydrolase HR084_RS20090 ENOG410667J hydrolase HR084_RS20120 ENOG4108V5C ABC transporter HR084_RS20150 ENOG4105D2N Aldolase HR084_RS20155 ENOG4107TRN Xylose isomerase domain protein TIM barrel HR084_RS20160 ENOG4105F0H myo-inositol catabolism protein HR084_RS20165 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HR084_RS20175 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HR084_RS20180 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HR084_RS20185 ENOG4105D7K pfkb domain protein HR084_RS20195 ENOG4105C26 Dehydrogenase HR084_RS20205 ENOG4105CPC Aldo Keto reductase HR084_RS20220 ENOG4107QNK )-transporter HR084_RS20225 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HR084_RS20235 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HR084_RS20240 ENOG4105ST3 Transcriptional regulator HR084_RS20245 ENOG4105C26 Dehydrogenase HR084_RS20250 ENOG4108YM7 Gcn5-related n-acetyltransferase HR084_RS20255 ENOG4105N1N Cupin superfamily protein HR084_RS20260 ENOG4107Y1Y Methyltransferase HR084_RS20275 ENOG4105CAQ asparagine synthetase HR084_RS20280 ENOG4105F22 Major Facilitator Superfamily HR084_RS20285 ENOG4108ITS PQQ enzyme repeat HR084_RS20295 ENOG41085PJ rdd domain containing protein HR084_RS20310 ENOG4105J7D transcriptional regulator HR084_RS20315 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HR084_RS20320 ENOG41061AU MarR family Transcriptional regulator HR084_RS20330 ENOG41067MG lrgb family HR084_RS20340 ENOG4105BZW Glycerate kinase HR084_RS20345 ENOG4105G3Z GntR family transcriptional regulator HR084_RS20350 ENOG4105CMG Carbohydrate kinase HR084_RS20355 ENOG4105C6Z Gluconate HR084_RS20360 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HR084_RS20365 ENOG4105D3R alkyl hydroperoxide reductase HR084_RS20370 ENOG4108JU3 Alkyl hydroperoxide reductase HR084_RS20375 ENOG4105CS2 ec 3.2.1.21 HR084_RS20385 ENOG4108S3Y transcriptional regulator HR084_RS20395 ENOG4106KKU HR084_RS20400 ENOG4108Z15 abc transporter atp-binding protein HR084_RS20405 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HR084_RS20440 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HR084_RS20455 ENOG4105E2A Dehydrogenase HR084_RS20475 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HR084_RS20480 ENOG4105WQG acetyltransferase HR084_RS20485 ENOG410780I phosphoprotein phosphatase activity HR084_RS20495 ENOG41066UZ arginase EC 3.5.3.1 HR084_RS20500 ENOG4108IQI permease HR084_RS20505 ENOG4105C8Y Acetylornithine aminotransferase HR084_RS20510 ENOG4108JUB Transcriptional regulator HR084_RS20515 ENOG4105BZU Histidine kinase HR084_RS20540 ENOG4105C0H protease HR084_RS20545 ENOG4105Q2H domain protein HR084_RS20560 ENOG4105BZU Histidine kinase HR084_RS20565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HR084_RS20590 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HR084_RS20595 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HR084_RS20600 ENOG4105CDU Replicative dna helicase HR084_RS20620 ENOG4105DJ2 Major Facilitator Superfamily HR084_RS20625 ENOG4105EDW glycosyl transferase, family 39 HR084_RS20630 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HR084_RS20635 ENOG4105BZR domain protein HR084_RS20640 ENOG4108XMW Membrane HR084_RS20655 ENOG4105KVH Transcriptional regulator HR084_RS20660 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HR084_RS20680 ENOG41090E6 transcriptional regulator MERR family HR084_RS20690 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HR084_RS20695 ENOG4105DDN Pentapeptide repeat-containing protein HR084_RS20700 ENOG4105D94 Major Facilitator Superfamily HR084_RS20705 ENOG4107RSM transcriptional regulator HR084_RS20710 ENOG41082BV acetyltransferase HR084_RS20715 ENOG41081I9 integral membrane protein HR084_RS20725 ENOG4108U05 Transcriptional regulator HR084_RS20730 ENOG41082BV acetyltransferase HR084_RS20740 ENOG4108U7W acetyltransferase HR084_RS20745 ENOG4105UNS Pfam:DUF419 HR084_RS20750 ENOG4105NAE bifunctional deaminase-reductase domain protein HR084_RS20760 ENOG4108J8C transporter major facilitator family protein HR084_RS20770 ENOG4105C7Z Conserved Protein HR084_RS20775 ENOG4107FCW Abortive infection protein HR084_RS20785 ENOG4108UW5 maltose o-acetyltransferase HR084_RS20790 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HR084_RS20800 ENOG4105CGK Exodeoxyribonuclease III HR084_RS20805 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HR084_RS20810 ENOG4108UUM single-stranded DNA-binding protein HR084_RS20815 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HR084_RS20820 ENOG4105C3G gtp-binding protein HR084_RS20825 ENOG4108J2R molybdopterin oxidoreductase HR084_RS20830 ENOG4105VDK protein, conserved in bacteria HR084_RS20840 ENOG4108ZDA Sporulation protein YyaC HR084_RS20845 ENOG4105FA0 parb-like partition protein HR084_RS20850 ENOG4107QJE Chromosome Partitioning Protein HR084_RS20865 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HR084_RS20870 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HR084_RS20875 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HR084_RS20890 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)