locus-tag	class	description
BSR08_RS00025	COG1309	transcriptional regulator
BSR08_RS00055	COG5578	integral membrane protein
BSR08_RS00060	COG2972	Histidine kinase
BSR08_RS00070	COG1653	transport
BSR08_RS00075	COG1175	transmembrane transport
BSR08_RS00080	COG0395	ABC-type sugar transport system, permease component
BSR08_RS00085	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BSR08_RS00090	COG2207	Transcriptional regulator
BSR08_RS00095	COG2755	lipolytic protein G-D-S-L family
BSR08_RS00105	COG5578	integral membrane protein
BSR08_RS00110	COG3401	FG-GAP repeat protein
BSR08_RS00115	COG3401	FG-GAP repeat protein
BSR08_RS00120	COG2755	lipolytic protein G-D-S-L family
BSR08_RS00135	COG1653	transport
BSR08_RS00140	COG4209	transmembrane transport
BSR08_RS00145	COG0395	ABC-type sugar transport system, permease component
BSR08_RS00150	COG1486	melibiose metabolic process
BSR08_RS00155	COG2323	membrane
BSR08_RS00160	COG2329	Antibiotic biosynthesis monooxygenase
BSR08_RS00165	COG0346	lactoylglutathione lyase activity
BSR08_RS00180	COG5583	Uncharacterized small protein (DUF2292)
BSR08_RS00185	COG0670	Belongs to the BI1 family
BSR08_RS00190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BSR08_RS00200	COG3328	transposase activity
BSR08_RS00210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BSR08_RS00210	COG2124	cytochrome p450
BSR08_RS00220	COG1368	sulfuric ester hydrolase activity
BSR08_RS00225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BSR08_RS00230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BSR08_RS00235	COG1442	glycosyl transferase family 8
BSR08_RS00240	COG1216	Glycosyl transferase, family 2
BSR08_RS00245	COG1442	glycosyl transferase family 8
BSR08_RS00250	COG2223	nitrite transmembrane transporter activity
BSR08_RS00255	COG1011	Hydrolase
BSR08_RS00260	COG0531	amino acid
BSR08_RS00265	COG1012	belongs to the aldehyde dehydrogenase family
BSR08_RS00270	COG0840	transmembrane signaling receptor activity
BSR08_RS00275	COG0488	(ABC) transporter
BSR08_RS00285	COG0789	Transcriptional regulator
BSR08_RS00290	COG2814	Major facilitator Superfamily
BSR08_RS00305	COG2801	Transposase and inactivated derivatives
BSR08_RS00310	COG0488	(ABC) transporter
BSR08_RS00315	COG0513	Belongs to the DEAD box helicase family
BSR08_RS00325	COG3866	Pectate lyase
BSR08_RS00330	COG0471	metal ion transport
BSR08_RS00335	COG3290	protein histidine kinase activity
BSR08_RS00340	COG4565	transcriptional regulatory protein
BSR08_RS00345	COG3181	Tripartite tricarboxylate transporter family receptor
BSR08_RS00350	COG2851	Citrate transporter
BSR08_RS00355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSR08_RS00360	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BSR08_RS00365	COG1254	Belongs to the acylphosphatase family
BSR08_RS00370	COG2258	MOSC domain
BSR08_RS00390	COG0024	Methionine aminopeptidase
BSR08_RS00395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS00395	COG1263	PTS System
BSR08_RS00400	COG1368	sulfuric ester hydrolase activity
BSR08_RS00415	COG1115	amino acid carrier protein
BSR08_RS00425	COG0697	spore germination
BSR08_RS00430	COG0697	spore germination
BSR08_RS00435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS00435	COG1263	PTS System
BSR08_RS00440	COG0366	Alpha amylase catalytic
BSR08_RS00445	COG2188	Transcriptional regulator
BSR08_RS00450	COG0778	Nitroreductase
BSR08_RS00455	COG0737	Belongs to the 5'-nucleotidase family
BSR08_RS00460	COG0693	protein deglycase activity
BSR08_RS00470	COG2801	Transposase and inactivated derivatives
BSR08_RS00475	COG2814	Major facilitator Superfamily
BSR08_RS00480	COG4840	Belongs to the UPF0435 family
BSR08_RS00485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BSR08_RS00490	COG4980	gas vesicle protein
BSR08_RS00495	COG1295	ribonuclease BN
BSR08_RS00500	COG0477	Major facilitator Superfamily
BSR08_RS00505	COG0387	Pfam Sodium calcium exchanger
BSR08_RS00515	COG0668	transmembrane transport
BSR08_RS00520	COG0535	radical SAM domain protein
BSR08_RS00530	COG0726	polysaccharide deacetylase
BSR08_RS00535	COG2084	Dehydrogenase
BSR08_RS00540	COG0598	Magnesium transport protein CorA
BSR08_RS00545	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BSR08_RS00550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSR08_RS00560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BSR08_RS00565	COG4637	Psort location Cytoplasmic, score
BSR08_RS00575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BSR08_RS00580	COG0022	dehydrogenase e1 component
BSR08_RS00585	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSR08_RS00590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSR08_RS00595	COG3284	Transcriptional regulator
BSR08_RS00605	COG1742	UPF0060 membrane protein
BSR08_RS00630	COG4842	Belongs to the WXG100 family
BSR08_RS00635	COG1486	melibiose metabolic process
BSR08_RS00640	COG1737	Transcriptional regulator
BSR08_RS00645	COG1263	PTS System
BSR08_RS00645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS00650	COG5434	Belongs to the glycosyl hydrolase 28 family
BSR08_RS00655	COG1132	(ABC) transporter
BSR08_RS00660	COG1132	(ABC) transporter
BSR08_RS00665	COG2259	Doxx family
BSR08_RS00670	COG2514	catechol 2,3-dioxygenase activity
BSR08_RS00675	COG4977	sequence-specific DNA binding
BSR08_RS00675	COG1917	Cupin 2, conserved barrel domain protein
BSR08_RS00680	COG2814	Major facilitator Superfamily
BSR08_RS00685	COG1082	Xylose isomerase domain protein TIM barrel
BSR08_RS00695	COG4585	Histidine kinase
BSR08_RS00700	COG2197	response regulator
BSR08_RS00705	COG1131	(ABC) transporter
BSR08_RS00710	COG0842	Transport permease protein
BSR08_RS00710	COG1511	domain protein
BSR08_RS00715	COG0842	Transport permease protein
BSR08_RS00720	COG1695	Transcriptional regulator
BSR08_RS00725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BSR08_RS00730	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
BSR08_RS00735	COG1309	transcriptional regulator
BSR08_RS00740	COG2814	Major facilitator Superfamily
BSR08_RS00745	COG2318	DinB family
BSR08_RS00755	COG1846	Transcriptional regulator
BSR08_RS00760	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BSR08_RS00760	COG0392	lysyltransferase activity
BSR08_RS00765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSR08_RS00770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR08_RS00775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR08_RS00780	COG0384	phenazine biosynthesis protein PhzF
BSR08_RS00785	COG0778	Nitroreductase
BSR08_RS00800	COG1090	epimerase
BSR08_RS00805	COG2137	regulation of response to DNA damage stimulus
BSR08_RS00815	COG2814	Major facilitator Superfamily
BSR08_RS00830	COG3103	Sh3 type 3 domain protein
BSR08_RS00835	COG5658	integral membrane protein
BSR08_RS00840	COG0596	Alpha beta hydrolase
BSR08_RS00845	COG0463	Glycosyl transferase, family 2
BSR08_RS00850	COG4485	Bacterial membrane protein, YfhO
BSR08_RS00855	COG1988	membrane-bound metal-dependent
BSR08_RS00860	COG1194	a g-specific adenine glycosylase
BSR08_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS00885	COG3557	Belongs to the UPF0374 family
BSR08_RS00890	COG1132	(ABC) transporter
BSR08_RS00895	COG4129	membrane
BSR08_RS00900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BSR08_RS00905	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BSR08_RS00910	COG0735	belongs to the Fur family
BSR08_RS01020	COG4326	sporulation control protein
BSR08_RS01030	COG5577	PFAM Coat F domain
BSR08_RS01035	COG3340	Belongs to the peptidase S51 family
BSR08_RS01040	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BSR08_RS01055	COG0753	catalase activity
BSR08_RS01060	COG1116	anion transmembrane transporter activity
BSR08_RS01065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSR08_RS01070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSR08_RS01075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSR08_RS01085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BSR08_RS01095	COG1476	TRANSCRIPTIONal
BSR08_RS01105	COG3382	B3 4 domain protein
BSR08_RS01110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BSR08_RS01120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BSR08_RS01125	COG0789	Transcriptional regulator
BSR08_RS01130	COG1664	Polymer-forming cytoskeletal
BSR08_RS01135	COG1664	Polymer-forming cytoskeletal
BSR08_RS01140	COG2766	serine protein kinase
BSR08_RS01145	COG2718	Belongs to the UPF0229 family
BSR08_RS01150	COG1846	Transcriptional regulator
BSR08_RS01155	COG1566	PFAM secretion protein HlyD family protein
BSR08_RS01160	COG2814	Major facilitator Superfamily
BSR08_RS01165	COG0655	NAD(P)H dehydrogenase (quinone) activity
BSR08_RS01185	COG1725	Transcriptional regulator
BSR08_RS01190	COG1131	(ABC) transporter
BSR08_RS01195	COG1131	(ABC) transporter
BSR08_RS01200	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BSR08_RS01205	COG1278	Cold shock
BSR08_RS01215	COG1464	Belongs to the NlpA lipoprotein family
BSR08_RS01220	COG3706	GGDEF domain
BSR08_RS01225	COG1823	symporter activity
BSR08_RS01230	COG5444	nuclease activity
BSR08_RS01255	COG0582	viral genome integration into host DNA
BSR08_RS01260	COG2946	Replication initiation factor
BSR08_RS01310	COG5644	endopeptidase inhibitor activity
BSR08_RS01315	COG0791	NLP P60 protein
BSR08_RS01315	COG0741	lytic transglycosylase activity
BSR08_RS01335	COG0457	Tetratricopeptide repeat
BSR08_RS01360	COG5577	PFAM Coat F domain
BSR08_RS01365	COG1525	nuclease
BSR08_RS01365	COG0737	Belongs to the 5'-nucleotidase family
BSR08_RS01365	COG4085	toxin activity
BSR08_RS01370	COG3764	Sortase (surface protein transpeptidase)
BSR08_RS01375	COG0564	pseudouridine synthase activity
BSR08_RS01385	COG0517	IMP dehydrogenase activity
BSR08_RS01390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BSR08_RS01395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSR08_RS01395	COG3153	acetyltransferase
BSR08_RS01400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BSR08_RS01405	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BSR08_RS01410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BSR08_RS01415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BSR08_RS01420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BSR08_RS01425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSR08_RS01430	COG2203	Gaf domain
BSR08_RS01430	COG4585	Histidine kinase
BSR08_RS01435	COG2197	response regulator
BSR08_RS01440	COG0431	NADPH-dependent FMN reductase
BSR08_RS01455	COG0791	NLP P60 protein
BSR08_RS01455	COG1388	LysM domain
BSR08_RS01460	COG1959	2 iron, 2 sulfur cluster binding
BSR08_RS01465	COG0668	transmembrane transport
BSR08_RS01470	COG2719	SpoVR family
BSR08_RS01475	COG1785	Belongs to the alkaline phosphatase family
BSR08_RS01480	COG0791	NLP P60 protein
BSR08_RS01480	COG1388	LysM domain
BSR08_RS01485	COG0583	DNA-binding transcription factor activity
BSR08_RS01490	COG0372	Belongs to the citrate synthase family
BSR08_RS01495	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS01500	COG0531	amino acid
BSR08_RS01505	COG0733	neurotransmitter:sodium symporter activity
BSR08_RS01510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR08_RS01515	COG0456	acetyltransferase
BSR08_RS01530	COG1595	DNA-templated transcription, initiation
BSR08_RS01535	COG0667	Aldo Keto reductase
BSR08_RS01540	COG0204	Acyl-transferase
BSR08_RS01545	COG1253	flavin adenine dinucleotide binding
BSR08_RS01550	COG0789	Transcriptional regulator
BSR08_RS01560	COG1253	flavin adenine dinucleotide binding
BSR08_RS01565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BSR08_RS01570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BSR08_RS01575	COG0584	glycerophosphoryl diester phosphodiesterase
BSR08_RS01585	COG0668	transmembrane transport
BSR08_RS01590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BSR08_RS01595	COG0726	polysaccharide deacetylase
BSR08_RS01600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BSR08_RS01605	COG1757	Na H antiporter
BSR08_RS01610	COG0589	response to stress
BSR08_RS01620	COG1132	(ABC) transporter
BSR08_RS01625	COG1132	(ABC) transporter
BSR08_RS01630	COG0702	epimerase
BSR08_RS01655	COG0189	ligase activity
BSR08_RS01660	COG0189	ligase activity
BSR08_RS01665	COG4399	Belongs to the UPF0754 family
BSR08_RS01670	COG3679	Belongs to the UPF0342 family
BSR08_RS01680	COG0561	phosphatase activity
BSR08_RS01685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BSR08_RS01690	COG0475	glutathione-regulated potassium exporter activity
BSR08_RS01695	COG0490	domain, Protein
BSR08_RS01705	COG1024	Enoyl-CoA hydratase
BSR08_RS01715	COG4152	abc transporter atp-binding protein
BSR08_RS01720	COG1668	transmembrane transport
BSR08_RS01725	COG0420	3'-5' exonuclease activity
BSR08_RS01730	COG4717	serine-type aminopeptidase activity
BSR08_RS01735	COG3481	metal-dependent phosphohydrolase, HD sub domain
BSR08_RS01745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSR08_RS01775	COG1846	Transcriptional regulator
BSR08_RS01780	COG4980	gas vesicle protein
BSR08_RS01795	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BSR08_RS01800	COG0537	adenosine 5'-monophosphoramidase activity
BSR08_RS01805	COG1131	(ABC) transporter
BSR08_RS01810	COG4473	ABC transporter
BSR08_RS01820	COG1473	amidohydrolase
BSR08_RS01825	COG3069	C4-dicarboxylate transmembrane transporter activity
BSR08_RS01835	COG2329	Antibiotic biosynthesis monooxygenase
BSR08_RS01840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSR08_RS01845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BSR08_RS01850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BSR08_RS01855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BSR08_RS01860	COG1309	transcriptional regulator
BSR08_RS01865	COG1511	domain protein
BSR08_RS01870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSR08_RS01875	COG4377	Putative membrane peptidase family (DUF2324)
BSR08_RS01885	COG1363	Peptidase, m42
BSR08_RS01890	COG4405	Protein conserved in bacteria
BSR08_RS01895	COG1301	dicarboxylic acid transport
BSR08_RS01905	COG1234	tRNA 3'-trailer cleavage
BSR08_RS01910	COG0095	Lipoate-protein ligase
BSR08_RS01915	COG0702	epimerase
BSR08_RS01920	COG0318	PFAM AMP-dependent synthetase and ligase
BSR08_RS01930	COG0501	Belongs to the peptidase M48B family
BSR08_RS01940	COG0456	acetyltransferase
BSR08_RS01945	COG0604	alcohol dehydrogenase
BSR08_RS01950	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BSR08_RS01955	COG0406	alpha-ribazole phosphatase activity
BSR08_RS01960	COG0183	Belongs to the thiolase family
BSR08_RS01965	COG0318	PFAM AMP-dependent synthetase and ligase
BSR08_RS01970	COG1268	BioY protein
BSR08_RS01975	COG0840	transmembrane signaling receptor activity
BSR08_RS01985	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS01995	COG4903	ComK protein
BSR08_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS02010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSR08_RS02025	COG0398	Pfam SNARE associated Golgi protein
BSR08_RS02030	COG0681	Belongs to the peptidase S26 family
BSR08_RS02035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BSR08_RS02040	COG1846	Transcriptional regulator
BSR08_RS02055	COG0738	Major facilitator superfamily
BSR08_RS02060	COG0673	inositol 2-dehydrogenase activity
BSR08_RS02065	COG0561	phosphatase activity
BSR08_RS02070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BSR08_RS02075	COG1609	Transcriptional regulator
BSR08_RS02080	COG3180	Ammonia monooxygenase
BSR08_RS02085	COG0477	Major facilitator Superfamily
BSR08_RS02085	COG2814	Major facilitator Superfamily
BSR08_RS02090	COG4533	DNA binding
BSR08_RS02110	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BSR08_RS02115	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BSR08_RS02120	COG1074	ATP-dependent DNA helicase activity
BSR08_RS02125	COG0420	3'-5' exonuclease activity
BSR08_RS02130	COG0419	ATPase involved in DNA repair
BSR08_RS02135	COG1403	HNH endonuclease
BSR08_RS02175	COG5337	Spore coat protein CotH
BSR08_RS02180	COG0179	Fumarylacetoacetate (FAA) hydrolase
BSR08_RS02190	COG1404	Belongs to the peptidase S8 family
BSR08_RS02200	COG0367	asparagine synthase
BSR08_RS02205	COG1562	ergosterol biosynthetic process
BSR08_RS02210	COG0534	Mate efflux family protein
BSR08_RS02215	COG2207	Transcriptional regulator
BSR08_RS02215	COG1917	Cupin 2, conserved barrel domain protein
BSR08_RS02220	COG1609	Transcriptional regulator
BSR08_RS02225	COG0673	inositol 2-dehydrogenase activity
BSR08_RS02230	COG2318	DinB family
BSR08_RS02235	COG1279	arginine transmembrane transporter activity
BSR08_RS02240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR08_RS02245	COG1357	PFAM Pentapeptide repeats (8 copies)
BSR08_RS02250	COG2267	carboxylic ester hydrolase activity
BSR08_RS02255	COG0454	-acetyltransferase
BSR08_RS02260	COG2153	protein acetylation
BSR08_RS02265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BSR08_RS02265	COG0646	methionine synthase
BSR08_RS02270	COG1666	GTP binding
BSR08_RS02275	COG2996	Protein conserved in bacteria
BSR08_RS02285	COG1307	EDD domain protein, DegV family
BSR08_RS02290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSR08_RS02305	COG0561	phosphatase activity
BSR08_RS02310	COG1073	alpha beta
BSR08_RS02315	COG2151	metal-sulfur cluster biosynthetic enzyme
BSR08_RS02335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BSR08_RS02340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BSR08_RS02350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BSR08_RS02355	COG0505	Belongs to the CarA family
BSR08_RS02360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BSR08_RS02365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BSR08_RS02370	COG2801	Transposase and inactivated derivatives
BSR08_RS02400	COG1744	ABC transporter substrate-binding protein PnrA-like
BSR08_RS02415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSR08_RS02420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BSR08_RS02425	COG5504	Zn-dependent protease
BSR08_RS02430	COG0444	Belongs to the ABC transporter superfamily
BSR08_RS02435	COG4608	Belongs to the ABC transporter superfamily
BSR08_RS02445	COG0601	transmembrane transport
BSR08_RS02450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSR08_RS02460	COG0180	Tryptophanyl-tRNA synthetase
BSR08_RS02465	COG4166	transmembrane transport
BSR08_RS02470	COG0601	transmembrane transport
BSR08_RS02475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSR08_RS02480	COG0444	Belongs to the ABC transporter superfamily
BSR08_RS02485	COG4608	Belongs to the ABC transporter superfamily
BSR08_RS02490	COG2814	Major facilitator Superfamily
BSR08_RS02495	COG0456	acetyltransferase
BSR08_RS02500	COG1393	Belongs to the ArsC family
BSR08_RS02505	COG0861	Integral membrane protein TerC family
BSR08_RS02510	COG4862	establishment of competence for transformation
BSR08_RS02515	COG4469	Competence protein
BSR08_RS02520	COG1164	Oligoendopeptidase f
BSR08_RS02535	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BSR08_RS02540	COG2346	COG2346, Truncated hemoglobins
BSR08_RS02545	COG0741	lytic transglycosylase activity
BSR08_RS02550	COG4116	CYTH
BSR08_RS02560	COG2357	RelA SpoT domain protein
BSR08_RS02565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BSR08_RS02570	COG0564	pseudouridine synthase activity
BSR08_RS02575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BSR08_RS02580	COG0569	domain protein
BSR08_RS02580	COG0475	glutathione-regulated potassium exporter activity
BSR08_RS02585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BSR08_RS02590	COG0352	thiamine-phosphate diphosphorylase activity
BSR08_RS02595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSR08_RS02600	COG2104	thiamine diphosphate biosynthetic process
BSR08_RS02605	COG2022	thiamine diphosphate biosynthetic process
BSR08_RS02610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSR08_RS02615	COG0351	phosphomethylpyrimidine kinase
BSR08_RS02620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BSR08_RS02675	COG0210	DNA helicase
BSR08_RS02685	COG2153	protein acetylation
BSR08_RS02690	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BSR08_RS02695	COG2382	esterase
BSR08_RS02700	COG0626	cystathionine gamma-synthase activity
BSR08_RS02705	COG0626	cystathionine gamma-synthase activity
BSR08_RS02710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR08_RS02715	COG5505	Protein of unknown function (DUF819)
BSR08_RS02750	COG1396	sequence-specific DNA binding
BSR08_RS02790	COG2801	Transposase and inactivated derivatives
BSR08_RS02830	COG0457	Tetratricopeptide repeat
BSR08_RS02835	COG5444	nuclease activity
BSR08_RS02845	COG3328	transposase activity
BSR08_RS02905	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BSR08_RS02915	COG3711	transcriptional antiterminator
BSR08_RS02915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR08_RS02920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR08_RS02920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR08_RS02920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR08_RS02925	COG1482	cell wall glycoprotein biosynthetic process
BSR08_RS02940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR08_RS02950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BSR08_RS02970	COG0109	protoheme IX farnesyltransferase activity
BSR08_RS02980	COG0726	polysaccharide deacetylase
BSR08_RS02995	COG5504	Zn-dependent protease
BSR08_RS03000	COG2205	protein histidine kinase activity
BSR08_RS03015	COG2427	Protein of unknown function (DUF1641)
BSR08_RS03025	COG1051	belongs to the nudix hydrolase family
BSR08_RS03035	COG2124	cytochrome p450
BSR08_RS03040	COG1819	glycosyl
BSR08_RS03050	COG1587	Uroporphyrinogen-III synthase
BSR08_RS03055	COG0390	transport system, permease component
BSR08_RS03060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSR08_RS03065	COG0697	spore germination
BSR08_RS03080	COG1252	NADH dehydrogenase
BSR08_RS03085	COG1904	glucuronate isomerase
BSR08_RS03090	COG2211	Major facilitator Superfamily
BSR08_RS03095	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BSR08_RS03100	COG1063	alcohol dehydrogenase
BSR08_RS03105	COG1312	Catalyzes the dehydration of D-mannonate
BSR08_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS03115	COG2271	Major facilitator Superfamily
BSR08_RS03120	COG1609	Transcriptional regulator
BSR08_RS03125	COG0246	Mannitol dehydrogenase
BSR08_RS03130	COG2721	sulfolactate sulfo-lyase activity
BSR08_RS03135	COG0730	response to heat
BSR08_RS03140	COG2318	DinB family
BSR08_RS03145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BSR08_RS03150	COG2801	Transposase and inactivated derivatives
BSR08_RS03160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BSR08_RS03165	COG0457	Tetratricopeptide repeat
BSR08_RS03180	COG1388	LysM domain
BSR08_RS03180	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS03180	COG5632	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS03190	COG4195	phage-related replication protein
BSR08_RS03195	COG3546	catalase activity
BSR08_RS03200	COG2856	Zn peptidase
BSR08_RS03205	COG1396	sequence-specific DNA binding
BSR08_RS03215	COG1522	sequence-specific DNA binding
BSR08_RS03220	COG1484	DNA-dependent DNA replication
BSR08_RS03240	COG1595	DNA-templated transcription, initiation
BSR08_RS03245	COG5484	DNA packaging
BSR08_RS03245	COG3728	DNA packaging
BSR08_RS03250	COG1783	phage Terminase large subunit
BSR08_RS03255	COG5518	Phage portal protein
BSR08_RS03260	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BSR08_RS03265	COG4653	Phage capsid family
BSR08_RS03315	COG5412	phage tail tape measure protein
BSR08_RS03315	COG3953	SLT domain
BSR08_RS03315	COG5412	phage tail tape measure protein
BSR08_RS03315	COG3953	SLT domain
BSR08_RS03315	COG5412	phage tail tape measure protein
BSR08_RS03315	COG3953	SLT domain
BSR08_RS03320	COG1652	LysM domain
BSR08_RS03325	COG4193	domain, Protein
BSR08_RS03335	COG3628	GPW Gp25 family protein
BSR08_RS03340	COG3299	homolog of phage Mu protein gp47
BSR08_RS03345	COG3778	Protein conserved in bacteria
BSR08_RS03385	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS03385	COG5632	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS03400	COG0306	phosphate transporter
BSR08_RS03405	COG1392	Phosphate transport regulator
BSR08_RS03410	COG0531	amino acid
BSR08_RS03415	COG0346	lactoylglutathione lyase activity
BSR08_RS03420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BSR08_RS03425	COG0463	Glycosyl transferase, family 2
BSR08_RS03430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSR08_RS03435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSR08_RS03440	COG2362	D-Aminopeptidase
BSR08_RS03445	COG0601	transmembrane transport
BSR08_RS03450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSR08_RS03455	COG0444	Belongs to the ABC transporter superfamily
BSR08_RS03460	COG4166	transmembrane transport
BSR08_RS03465	COG1619	proteins homologs of microcin C7 resistance protein MccF
BSR08_RS03470	COG4948	Mandelate Racemase Muconate Lactonizing
BSR08_RS03475	COG0791	NLP P60 protein
BSR08_RS03480	COG4608	Belongs to the ABC transporter superfamily
BSR08_RS03485	COG2706	6-phosphogluconolactonase activity
BSR08_RS03495	COG1607	acyl-coa hydrolase
BSR08_RS03500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BSR08_RS03500	COG1017	nitric oxide dioxygenase activity
BSR08_RS03510	COG2323	membrane
BSR08_RS03515	COG2318	DinB family
BSR08_RS03520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR08_RS03525	COG2076	Multidrug Resistance protein
BSR08_RS03530	COG2076	Multidrug Resistance protein
BSR08_RS03535	COG0788	formyltetrahydrofolate deformylase activity
BSR08_RS03540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BSR08_RS03545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BSR08_RS03550	COG1764	response to oxidative stress
BSR08_RS03555	COG1846	Transcriptional regulator
BSR08_RS03560	COG1764	response to oxidative stress
BSR08_RS03570	COG0590	tRNA wobble adenosine to inosine editing
BSR08_RS03575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BSR08_RS03580	COG1404	Belongs to the peptidase S8 family
BSR08_RS03585	COG1366	Belongs to the anti-sigma-factor antagonist family
BSR08_RS03590	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BSR08_RS03595	COG1122	ATPase activity
BSR08_RS03600	COG4721	ABC-type cobalt transport system, permease component
BSR08_RS03610	COG0745	RESPONSE REGULATOR receiver
BSR08_RS03615	COG5002	protein histidine kinase activity
BSR08_RS03615	COG3850	Histidine kinase
BSR08_RS03620	COG3212	peptidase
BSR08_RS03625	COG3212	peptidase
BSR08_RS03640	COG2239	Acts as a magnesium transporter
BSR08_RS03645	COG0789	Transcriptional regulator
BSR08_RS03660	COG1846	Transcriptional regulator
BSR08_RS03665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BSR08_RS03670	COG0726	polysaccharide deacetylase
BSR08_RS03675	COG1408	metallophosphoesterase
BSR08_RS03685	COG0463	Glycosyl transferase, family 2
BSR08_RS03690	COG3285	dna ligase
BSR08_RS03690	COG1793	dna ligase
BSR08_RS03695	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BSR08_RS03700	COG3300	MHYT domain
BSR08_RS03700	COG5001	Diguanylate cyclase
BSR08_RS03705	COG0586	Pfam SNARE associated Golgi protein
BSR08_RS03710	COG0861	Integral membrane protein TerC family
BSR08_RS03715	COG1191	sigma factor activity
BSR08_RS03735	COG0501	Belongs to the peptidase M48B family
BSR08_RS03740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BSR08_RS03760	COG3594	Acyltransferase
BSR08_RS03765	COG5002	protein histidine kinase activity
BSR08_RS03770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BSR08_RS03775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BSR08_RS03780	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BSR08_RS03785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSR08_RS03790	COG0436	Aminotransferase
BSR08_RS03795	COG1850	ribulose-bisphosphate carboxylase activity
BSR08_RS03800	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BSR08_RS03805	COG0235	Class ii aldolase
BSR08_RS03810	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BSR08_RS03815	COG3339	Conserved Protein
BSR08_RS03830	COG3852	Histidine kinase
BSR08_RS03835	COG1846	Transcriptional regulator
BSR08_RS03840	COG1360	Flagellar Motor Protein
BSR08_RS03845	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BSR08_RS03850	COG0542	response to heat
BSR08_RS03855	COG3949	Membrane
BSR08_RS03860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BSR08_RS03865	COG0720	synthase
BSR08_RS03870	COG0602	queuosine metabolic process
BSR08_RS03875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BSR08_RS03885	COG4873	Protein conserved in bacteria
BSR08_RS03895	COG3773	Cell wall hydrolase
BSR08_RS03900	COG2244	polysaccharide biosynthetic process
BSR08_RS03905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR08_RS03910	COG2217	Heavy metal translocating P-type atpase
BSR08_RS03920	COG0006	proline dipeptidase activity
BSR08_RS03925	COG1609	Transcriptional regulator
BSR08_RS03930	COG3711	transcriptional antiterminator
BSR08_RS03935	COG2190	(PTS) system
BSR08_RS03935	COG1263	PTS System
BSR08_RS03935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS03940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR08_RS03945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BSR08_RS03955	COG1533	DNA photolyase activity
BSR08_RS03960	COG0456	acetyltransferase
BSR08_RS03965	COG0840	transmembrane signaling receptor activity
BSR08_RS03970	COG2084	Dehydrogenase
BSR08_RS03975	COG3328	transposase activity
BSR08_RS03980	COG2340	Cysteine-rich secretory protein family
BSR08_RS03985	COG0768	penicillin binding
BSR08_RS03990	COG4191	Histidine kinase
BSR08_RS04005	COG0436	Aminotransferase
BSR08_RS04015	COG0835	chemotaxis
BSR08_RS04015	COG0784	Response regulator, receiver
BSR08_RS04025	COG2814	Major facilitator Superfamily
BSR08_RS04030	COG1376	ErfK ybiS ycfS ynhG family protein
BSR08_RS04035	COG1408	metallophosphoesterase
BSR08_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS04045	COG2200	EAL domain
BSR08_RS04050	COG4703	Protein of unknown function (DUF1797)
BSR08_RS04055	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BSR08_RS04065	COG0517	IMP dehydrogenase activity
BSR08_RS04070	COG0583	DNA-binding transcription factor activity
BSR08_RS04075	COG0716	FMN binding
BSR08_RS04085	COG0716	FMN binding
BSR08_RS04090	COG2171	N-acyltransferase activity
BSR08_RS04095	COG1473	amidohydrolase
BSR08_RS04105	COG0668	transmembrane transport
BSR08_RS04110	COG0450	alkyl hydroperoxide reductase
BSR08_RS04115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR08_RS04125	COG2801	Transposase and inactivated derivatives
BSR08_RS04140	COG0746	molybdenum cofactor guanylyltransferase activity
BSR08_RS04145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSR08_RS04150	COG0303	'Molybdopterin
BSR08_RS04155	COG1763	Mo-molybdopterin cofactor biosynthetic process
BSR08_RS04160	COG0314	molybdopterin synthase activity
BSR08_RS04165	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BSR08_RS04175	COG1132	(ABC) transporter
BSR08_RS04185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR08_RS04190	COG1136	(ABC) transporter
BSR08_RS04195	COG0577	efflux transmembrane transporter activity
BSR08_RS04200	COG1349	DNA-binding transcription factor activity
BSR08_RS04205	COG1105	Belongs to the carbohydrate kinase PfkB family
BSR08_RS04210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR08_RS04210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR08_RS04210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSR08_RS04215	COG0681	Belongs to the peptidase S26 family
BSR08_RS04225	COG0488	(ABC) transporter
BSR08_RS04230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BSR08_RS04235	COG2309	aminopeptidase activity
BSR08_RS04245	COG1077	Cell shape determining protein MreB Mrl
BSR08_RS04250	COG2002	toxin-antitoxin pair type II binding
BSR08_RS04255	COG3852	Histidine kinase
BSR08_RS04260	COG2105	PFAM AIG2 family protein
BSR08_RS04260	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BSR08_RS04265	COG0569	domain protein
BSR08_RS04270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BSR08_RS04275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BSR08_RS04280	COG5503	Protein of unknown function (DUF1447)
BSR08_RS04285	COG0561	phosphatase activity
BSR08_RS04290	COG0242	peptide deformylase activity
BSR08_RS04305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BSR08_RS04310	COG0022	dehydrogenase e1 component
BSR08_RS04315	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSR08_RS04320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSR08_RS04325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR08_RS04335	COG1982	Orn Lys Arg decarboxylase major
BSR08_RS04340	COG4476	Belongs to the UPF0223 family
BSR08_RS04345	COG4493	Belongs to the UPF0637 family
BSR08_RS04355	COG0483	inositol monophosphate 1-phosphatase activity
BSR08_RS04370	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BSR08_RS04415	COG1217	gtp-binding protein TYPA
BSR08_RS04425	COG4896	Protein conserved in bacteria
BSR08_RS04435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BSR08_RS04440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BSR08_RS04445	COG2066	Belongs to the glutaminase family
BSR08_RS04450	COG4838	Belongs to the UPF0358 family
BSR08_RS04455	COG0772	Belongs to the SEDS family
BSR08_RS04460	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BSR08_RS04465	COG1612	heme a metabolic process
BSR08_RS04470	COG0109	protoheme IX farnesyltransferase activity
BSR08_RS04475	COG2010	Cytochrome c
BSR08_RS04475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BSR08_RS04480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BSR08_RS04485	COG1845	cytochrome c oxidase, subunit III
BSR08_RS04490	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BSR08_RS04495	COG3336	cytochrome c oxidase
BSR08_RS04505	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BSR08_RS04510	COG2340	Cysteine-rich secretory protein family
BSR08_RS04525	COG3679	Belongs to the UPF0342 family
BSR08_RS04530	COG4471	UPF0298 protein
BSR08_RS04535	COG0742	ribosomal rna small subunit methyltransferase
BSR08_RS04540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BSR08_RS04545	COG3314	Sporulation integral membrane protein YlbJ
BSR08_RS04550	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSR08_RS04555	COG3480	Lon protease (S16) C-terminal proteolytic domain
BSR08_RS04560	COG1323	Belongs to the UPF0348 family
BSR08_RS04570	COG1399	metal-binding, possibly nucleic acid-binding protein
BSR08_RS04585	COG0454	-acetyltransferase
BSR08_RS04590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BSR08_RS04595	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BSR08_RS04600	COG2001	Belongs to the MraZ family
BSR08_RS04605	COG0275	rRNA processing
BSR08_RS04610	COG4839	cell division protein FtsL
BSR08_RS04615	COG0768	penicillin binding
BSR08_RS04620	COG0768	penicillin binding
BSR08_RS04625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BSR08_RS04630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BSR08_RS04635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BSR08_RS04640	COG0772	Belongs to the SEDS family
BSR08_RS04645	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BSR08_RS04650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BSR08_RS04655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BSR08_RS04660	COG3879	Bacterial protein of unknown function (DUF881)
BSR08_RS04665	COG3879	Bacterial protein of unknown function (DUF881)
BSR08_RS04670	COG3856	small basic protein
BSR08_RS04675	COG0849	cell division
BSR08_RS04680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BSR08_RS04685	COG1404	Belongs to the peptidase S8 family
BSR08_RS04685	COG4412	M6 family metalloprotease domain protein
BSR08_RS04695	COG1191	sigma factor activity
BSR08_RS04700	COG1191	sigma factor activity
BSR08_RS04705	COG1119	ATPase activity
BSR08_RS04710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSR08_RS04715	COG1873	PFAM PRC-barrel domain
BSR08_RS04720	COG1496	oxidoreductase activity
BSR08_RS04725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BSR08_RS04730	COG1799	cell septum assembly
BSR08_RS04735	COG0762	integral membrane protein
BSR08_RS04740	COG2302	S4 RNA-binding domain
BSR08_RS04745	COG3599	regulation of cell shape
BSR08_RS04750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BSR08_RS04755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BSR08_RS04760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BSR08_RS04765	COG0564	pseudouridine synthase activity
BSR08_RS04770	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BSR08_RS04775	COG2233	PERMEase
BSR08_RS04780	COG0540	Belongs to the ATCase OTCase family
BSR08_RS04785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BSR08_RS04790	COG0505	Belongs to the CarA family
BSR08_RS04795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BSR08_RS04800	COG0543	2 iron, 2 sulfur cluster binding
BSR08_RS04805	COG0167	dihydroorotate dehydrogenase activity
BSR08_RS04810	COG0284	orotidine-5'-phosphate decarboxylase activity
BSR08_RS04815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BSR08_RS04820	COG0175	sulfate reduction
BSR08_RS04825	COG0306	phosphate transporter
BSR08_RS04830	COG2046	Belongs to the sulfate adenylyltransferase family
BSR08_RS04835	COG0529	Catalyzes the synthesis of activated sulfate
BSR08_RS04840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BSR08_RS04845	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BSR08_RS04850	COG1648	precorrin-2 dehydrogenase activity
BSR08_RS04860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BSR08_RS04865	COG1561	YicC-like family, N-terminal region
BSR08_RS04875	COG0194	GDP metabolic process
BSR08_RS04880	COG1758	RNA polymerase activity
BSR08_RS04885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BSR08_RS04890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BSR08_RS04895	COG0242	peptide deformylase activity
BSR08_RS04900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BSR08_RS04905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSR08_RS04905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BSR08_RS04910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BSR08_RS04915	COG0631	protein serine/threonine phosphatase activity
BSR08_RS04920	COG0515	serine threonine protein kinase
BSR08_RS04920	COG2815	serine threonine protein kinase
BSR08_RS04925	COG1162	GTPase activity
BSR08_RS04930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BSR08_RS04935	COG1564	THIamine pyrophosphokinase
BSR08_RS04945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BSR08_RS04950	COG1302	Protein conserved in bacteria
BSR08_RS04955	COG1461	Dihydroxyacetone kinase
BSR08_RS04960	COG1760	l-serine dehydratase
BSR08_RS04965	COG1760	l-serine dehydratase
BSR08_RS04970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BSR08_RS04975	COG2050	protein possibly involved in aromatic compounds catabolism
BSR08_RS04975	COG1349	DNA-binding transcription factor activity
BSR08_RS04980	COG0416	fatty acid biosynthetic process
BSR08_RS04985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BSR08_RS04990	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS05000	COG0571	ribonuclease III activity
BSR08_RS05005	COG1196	nuclear chromosome segregation
BSR08_RS05010	COG0552	protein localization to endoplasmic reticulum
BSR08_RS05020	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BSR08_RS05025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BSR08_RS05030	COG0228	four-way junction DNA binding
BSR08_RS05035	COG1837	Belongs to the UPF0109 family
BSR08_RS05045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BSR08_RS05050	COG0336	Belongs to the RNA methyltransferase TrmD family
BSR08_RS05055	COG0335	large ribosomal subunit rRNA binding
BSR08_RS05060	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BSR08_RS05065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BSR08_RS05075	COG2257	FlhB HrpN YscU SpaS Family
BSR08_RS05080	COG0045	succinate-CoA ligase (ADP-forming) activity
BSR08_RS05085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BSR08_RS05090	COG0758	DNA mediated transformation
BSR08_RS05095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BSR08_RS05100	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BSR08_RS05105	COG4974	Belongs to the 'phage' integrase family
BSR08_RS05110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BSR08_RS05115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BSR08_RS05120	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BSR08_RS05125	COG1815	bacterial-type flagellum-dependent cell motility
BSR08_RS05130	COG1558	bacterial-type flagellum-dependent cell motility
BSR08_RS05135	COG1677	Flagellar hook-basal body complex protein FliE
BSR08_RS05145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSR08_RS05150	COG1317	bacterial-type flagellum organization
BSR08_RS05155	COG1157	protein secretion by the type III secretion system
BSR08_RS05160	COG2882	bacterial-type flagellum organization
BSR08_RS05165	COG3334	PFAM MgtE intracellular
BSR08_RS05170	COG3144	bacterial-type flagellum assembly
BSR08_RS05175	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BSR08_RS05180	COG4786	Flagellar basal body rod
BSR08_RS05185	COG1582	Flagellar protein (FlbD)
BSR08_RS05190	COG1580	Controls the rotational direction of flagella during chemotaxis
BSR08_RS05195	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSR08_RS05200	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSR08_RS05200	COG1776	CheC inhibitor of MCP methylation
BSR08_RS05205	COG2201	protein-glutamate methylesterase activity
BSR08_RS05210	COG3190	flagellar
BSR08_RS05215	COG1338	Plays a role in the flagellum-specific transport system
BSR08_RS05220	COG1987	bacterial-type flagellum assembly
BSR08_RS05225	COG1684	flagellar biosynthetic protein fliR
BSR08_RS05230	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BSR08_RS05235	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BSR08_RS05240	COG1419	protein localization to endoplasmic reticulum
BSR08_RS05245	COG0455	bacterial-type flagellum organization
BSR08_RS05250	COG2201	protein-glutamate methylesterase activity
BSR08_RS05255	COG0643	Histidine kinase
BSR08_RS05255	COG2198	Histidine kinase
BSR08_RS05260	COG0835	chemotaxis
BSR08_RS05270	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BSR08_RS05275	COG1191	sigma factor activity
BSR08_RS05285	COG0052	Belongs to the universal ribosomal protein uS2 family
BSR08_RS05290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BSR08_RS05295	COG0528	UMP kinase activity
BSR08_RS05300	COG0233	cytoplasmic translational termination
BSR08_RS05305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BSR08_RS05310	COG4589	Belongs to the CDS family
BSR08_RS05315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BSR08_RS05320	COG0750	zinc metalloprotease
BSR08_RS05325	COG0442	prolyl-tRNA aminoacylation
BSR08_RS05330	COG2176	DNA-directed DNA polymerase activity
BSR08_RS05335	COG0779	Required for maturation of 30S ribosomal subunits
BSR08_RS05340	COG0195	Participates in both transcription termination and antitermination
BSR08_RS05345	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BSR08_RS05350	COG1358	cellular component organization or biogenesis
BSR08_RS05355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BSR08_RS05360	COG1550	Protein conserved in bacteria
BSR08_RS05365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BSR08_RS05370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BSR08_RS05375	COG0196	riboflavin kinase activity
BSR08_RS05380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BSR08_RS05385	COG1185	polyribonucleotide nucleotidyltransferase activity
BSR08_RS05390	COG0726	polysaccharide deacetylase
BSR08_RS05395	COG0612	Peptidase, M16
BSR08_RS05400	COG1873	PFAM PRC-barrel domain
BSR08_RS05405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSR08_RS05410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BSR08_RS05415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BSR08_RS05420	COG0527	aspartate kinase activity
BSR08_RS05425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BSR08_RS05430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BSR08_RS05435	COG0740	serine-type endopeptidase activity
BSR08_RS05445	COG4980	gas vesicle protein
BSR08_RS05445	COG1674	ftsk spoiiie
BSR08_RS05450	COG2188	Transcriptional regulator
BSR08_RS05455	COG2814	Major facilitator Superfamily
BSR08_RS05460	COG0612	Peptidase, M16
BSR08_RS05465	COG0612	Peptidase, M16
BSR08_RS05470	COG0300	oxidoreductase activity
BSR08_RS05485	COG1426	Protein conserved in bacteria
BSR08_RS05490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BSR08_RS05495	COG1058	Belongs to the CinA family
BSR08_RS05495	COG1546	Belongs to the CinA family
BSR08_RS05500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BSR08_RS05505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BSR08_RS05510	COG1418	mRNA catabolic process
BSR08_RS05515	COG1692	metallophosphoesterase
BSR08_RS05520	COG2359	stage V sporulation protein S
BSR08_RS05525	COG1063	alcohol dehydrogenase
BSR08_RS05530	COG0156	8-amino-7-oxononanoate synthase activity
BSR08_RS05535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BSR08_RS05540	COG4550	Control of competence regulator ComK, YlbF/YmcA
BSR08_RS05550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BSR08_RS05555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BSR08_RS05655	COG3226	Transcriptional regulator
BSR08_RS05665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSR08_RS05670	COG1404	Belongs to the peptidase S8 family
BSR08_RS05680	COG4195	phage-related replication protein
BSR08_RS05685	COG1764	response to oxidative stress
BSR08_RS05690	COG2076	Multidrug Resistance protein
BSR08_RS05695	COG2076	Multidrug Resistance protein
BSR08_RS05710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BSR08_RS05715	COG1923	regulation of RNA biosynthetic process
BSR08_RS05730	COG1780	Probably involved in ribonucleotide reductase function
BSR08_RS05735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSR08_RS05740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSR08_RS05745	COG4112	unkown
BSR08_RS05750	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS05760	COG0464	growth
BSR08_RS05765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BSR08_RS05770	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BSR08_RS05775	COG0789	Transcriptional regulator
BSR08_RS05780	COG0174	glutamine synthetase
BSR08_RS05785	COG4974	Belongs to the 'phage' integrase family
BSR08_RS05805	COG3646	Phage regulatory protein
BSR08_RS05805	COG3645	SOS response
BSR08_RS05950	COG3953	SLT domain
BSR08_RS05950	COG5412	phage tail tape measure protein
BSR08_RS05995	COG5632	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS05995	COG1388	LysM domain
BSR08_RS05995	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS06005	COG5444	nuclease activity
BSR08_RS06045	COG4282	regulation of fungal-type cell wall biogenesis
BSR08_RS06080	COG3655	Transcriptional regulator
BSR08_RS06105	COG0135	phosphoribosylanthranilate isomerase activity
BSR08_RS06110	COG2211	Major facilitator Superfamily
BSR08_RS06125	COG3507	Belongs to the glycosyl hydrolase 43 family
BSR08_RS06130	COG1940	carbohydrate kinase activity
BSR08_RS06135	COG2115	Belongs to the xylose isomerase family
BSR08_RS06140	COG1070	Carbohydrate kinase
BSR08_RS06150	COG3328	transposase activity
BSR08_RS06155	COG1525	nuclease
BSR08_RS06160	COG2814	Major facilitator Superfamily
BSR08_RS06165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BSR08_RS06180	COG0756	dUTP diphosphatase activity
BSR08_RS06220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSR08_RS06235	COG3832	glyoxalase III activity
BSR08_RS06280	COG4195	phage-related replication protein
BSR08_RS06290	COG0346	lactoylglutathione lyase activity
BSR08_RS06300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BSR08_RS06305	COG1388	LysM domain
BSR08_RS06310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BSR08_RS06315	COG4224	UPF0291 protein
BSR08_RS06320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BSR08_RS06330	COG3763	UPF0154 protein
BSR08_RS06340	COG0785	Cytochrome C biogenesis protein
BSR08_RS06345	COG2201	protein-glutamate methylesterase activity
BSR08_RS06350	COG4846	Membrane protein involved in cytochrome C biogenesis
BSR08_RS06360	COG0071	Belongs to the small heat shock protein (HSP20) family
BSR08_RS06375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BSR08_RS06380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR08_RS06400	COG0824	Thioesterase
BSR08_RS06410	COG4841	protein insertion into membrane
BSR08_RS06415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BSR08_RS06420	COG1832	CoA-binding protein
BSR08_RS06425	COG0187	DNA topoisomerase II activity
BSR08_RS06430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BSR08_RS06440	COG1115	amino acid carrier protein
BSR08_RS06445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BSR08_RS06455	COG5520	Belongs to the glycosyl hydrolase 30 family
BSR08_RS06465	COG2246	polysaccharide biosynthetic process
BSR08_RS06470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSR08_RS06475	COG0586	Pfam SNARE associated Golgi protein
BSR08_RS06480	COG2404	hydrolase activity, acting on ester bonds
BSR08_RS06485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BSR08_RS06490	COG1024	Enoyl-CoA hydratase
BSR08_RS06495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSR08_RS06500	COG0511	ligase activity, forming carbon-carbon bonds
BSR08_RS06505	COG0439	Biotin carboxylase
BSR08_RS06510	COG0318	PFAM AMP-dependent synthetase and ligase
BSR08_RS06515	COG1960	acyl-CoA dehydrogenase activity
BSR08_RS06525	COG1649	PFAM Uncharacterised BCR, COG1649
BSR08_RS06540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BSR08_RS06545	COG2027	D-alanyl-D-alanine carboxypeptidase
BSR08_RS06550	COG2017	converts alpha-aldose to the beta-anomer
BSR08_RS06555	COG0534	Mate efflux family protein
BSR08_RS06570	COG2801	Transposase and inactivated derivatives
BSR08_RS06580	COG0582	viral genome integration into host DNA
BSR08_RS06585	COG0166	Belongs to the GPI family
BSR08_RS06590	COG0405	Gamma-glutamyltransferase
BSR08_RS06595	COG0583	DNA-binding transcription factor activity
BSR08_RS06600	COG0604	alcohol dehydrogenase
BSR08_RS06605	COG0493	'glutamate synthase
BSR08_RS06610	COG0070	glutamate synthase
BSR08_RS06610	COG0067	glutamate synthase
BSR08_RS06610	COG0069	glutamate synthase activity
BSR08_RS06615	COG0583	DNA-binding transcription factor activity
BSR08_RS06620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BSR08_RS06625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSR08_RS06630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSR08_RS06640	COG0300	oxidoreductase activity
BSR08_RS06645	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BSR08_RS06655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR08_RS06670	COG1131	(ABC) transporter
BSR08_RS06680	COG2814	Major facilitator Superfamily
BSR08_RS06685	COG3328	transposase activity
BSR08_RS06710	COG2801	Transposase and inactivated derivatives
BSR08_RS06730	COG3328	transposase activity
BSR08_RS06785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSR08_RS06790	COG2226	methyltransferase
BSR08_RS06795	COG2211	Major facilitator Superfamily
BSR08_RS06800	COG3328	transposase activity
BSR08_RS06830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR08_RS06850	COG5444	nuclease activity
BSR08_RS06855	COG4282	regulation of fungal-type cell wall biogenesis
BSR08_RS06860	COG1231	oxidoreductase activity
BSR08_RS06865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSR08_RS06870	COG0662	Cupin 2, conserved barrel domain protein
BSR08_RS06870	COG2207	Transcriptional regulator
BSR08_RS06875	COG0456	acetyltransferase
BSR08_RS06880	COG1309	transcriptional regulator
BSR08_RS06885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSR08_RS06890	COG3708	Transcriptional regulator
BSR08_RS06895	COG2378	regulation of single-species biofilm formation
BSR08_RS06905	COG0640	Transcriptional regulator
BSR08_RS06910	COG0741	lytic transglycosylase activity
BSR08_RS06915	COG2322	membrane
BSR08_RS06930	COG1619	proteins homologs of microcin C7 resistance protein MccF
BSR08_RS06935	COG3239	Fatty acid desaturase
BSR08_RS06940	COG4585	Histidine kinase
BSR08_RS06945	COG2197	response regulator
BSR08_RS06950	COG1388	LysM domain
BSR08_RS06950	COG3584	3D domain protein
BSR08_RS06955	COG0514	ATP-dependent DNA helicase (RecQ)
BSR08_RS06970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BSR08_RS06975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BSR08_RS06990	COG0071	Belongs to the small heat shock protein (HSP20) family
BSR08_RS07015	COG1012	belongs to the aldehyde dehydrogenase family
BSR08_RS07020	COG1657	PFAM Prenyltransferase squalene oxidase
BSR08_RS07025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BSR08_RS07030	COG0733	neurotransmitter:sodium symporter activity
BSR08_RS07035	COG0385	Bile acid
BSR08_RS07040	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSR08_RS07045	COG0567	Dehydrogenase, E1 component
BSR08_RS07050	COG4548	von Willebrand factor, type A
BSR08_RS07055	COG0714	Associated with various cellular activities
BSR08_RS07060	COG2032	superoxide dismutase activity
BSR08_RS07065	COG0791	NLP P60 protein
BSR08_RS07065	COG1388	LysM domain
BSR08_RS07070	COG1819	glycosyl
BSR08_RS07075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BSR08_RS07080	COG0534	Mate efflux family protein
BSR08_RS07085	COG1366	Belongs to the anti-sigma-factor antagonist family
BSR08_RS07090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BSR08_RS07095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BSR08_RS07105	COG2962	Rard protein
BSR08_RS07125	COG1942	4-Oxalocrotonate Tautomerase
BSR08_RS07130	COG1733	regulation of RNA biosynthetic process
BSR08_RS07135	COG0778	Nitroreductase
BSR08_RS07145	COG2801	Transposase and inactivated derivatives
BSR08_RS07150	COG0400	carboxylic ester hydrolase activity
BSR08_RS07165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSR08_RS07170	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS07170	COG0793	Belongs to the peptidase S41A family
BSR08_RS07175	COG2226	methyltransferase
BSR08_RS07185	COG1876	peptidase activity
BSR08_RS07190	COG0813	purine-nucleoside phosphorylase activity
BSR08_RS07205	COG0671	phosphoesterase, PA-phosphatase related
BSR08_RS07230	COG4479	Belongs to the UPF0346 family
BSR08_RS07240	COG1509	lysine 2,3-aminomutase activity
BSR08_RS07245	COG0456	acetyltransferase
BSR08_RS07250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSR08_RS07255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BSR08_RS07260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BSR08_RS07265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BSR08_RS07275	COG0456	acetyltransferase
BSR08_RS07280	COG0463	Glycosyl transferase, family 2
BSR08_RS07295	COG4641	Protein conserved in bacteria
BSR08_RS07300	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
BSR08_RS07305	COG1086	Polysaccharide biosynthesis protein
BSR08_RS07310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSR08_RS07315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSR08_RS07320	COG1846	Transcriptional regulator
BSR08_RS07325	COG0534	Mate efflux family protein
BSR08_RS07335	COG4698	Protein conserved in bacteria
BSR08_RS07340	COG2755	lipolytic protein G-D-S-L family
BSR08_RS07345	COG1999	signal sequence binding
BSR08_RS07355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BSR08_RS07360	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BSR08_RS07365	COG1272	protein, Hemolysin III
BSR08_RS07370	COG0204	Acyl-transferase
BSR08_RS07375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BSR08_RS07380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BSR08_RS07390	COG2521	methyltransferase
BSR08_RS07390	COG2136	Putative SAM-dependent methyltransferase
BSR08_RS07400	COG0129	dihydroxy-acid dehydratase activity
BSR08_RS07405	COG1413	lyase activity
BSR08_RS07410	COG1418	mRNA catabolic process
BSR08_RS07415	COG0386	Belongs to the glutathione peroxidase family
BSR08_RS07420	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BSR08_RS07425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BSR08_RS07430	COG1278	Cold shock
BSR08_RS07450	COG0328	RNA-DNA hybrid ribonuclease activity
BSR08_RS07455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BSR08_RS07460	COG0328	RNA-DNA hybrid ribonuclease activity
BSR08_RS07470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSR08_RS07485	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BSR08_RS07495	COG1755	Isoprenylcysteine carboxyl methyltransferase
BSR08_RS07500	COG3424	synthase
BSR08_RS07505	COG2233	PERMEase
BSR08_RS07510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSR08_RS07515	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BSR08_RS07525	COG0800	Aldolase
BSR08_RS07530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSR08_RS07535	COG1609	Transcriptional regulator
BSR08_RS07540	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BSR08_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS07550	COG1199	ATP-dependent helicase activity
BSR08_RS07565	COG0116	Belongs to the methyltransferase superfamily
BSR08_RS07580	COG4474	Belongs to the UPF0398 family
BSR08_RS07590	COG3359	exonuclease
BSR08_RS07595	COG1205	dead DEAH box helicase
BSR08_RS07595	COG1111	helicase
BSR08_RS07600	COG2190	(PTS) system
BSR08_RS07605	COG0071	Belongs to the small heat shock protein (HSP20) family
BSR08_RS07640	COG3331	DNA recombination
BSR08_RS07645	COG4499	WXG100 protein secretion system (Wss), protein YukC
BSR08_RS07645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSR08_RS07655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BSR08_RS07660	COG3935	DnaD domain protein
BSR08_RS07665	COG0017	Asparaginyl-tRNA synthetase
BSR08_RS07670	COG0436	Aminotransferase
BSR08_RS07675	COG5353	protein conserved in bacteria
BSR08_RS07685	COG1199	ATP-dependent helicase activity
BSR08_RS07685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BSR08_RS07690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BSR08_RS07695	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BSR08_RS07700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BSR08_RS07705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BSR08_RS07705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BSR08_RS07710	COG0617	tRNA 3'-terminal CCA addition
BSR08_RS07715	COG0438	transferase activity, transferring glycosyl groups
BSR08_RS07720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BSR08_RS07725	COG1803	Methylglyoxal synthase
BSR08_RS07730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BSR08_RS07735	COG1694	Mazg nucleotide pyrophosphohydrolase
BSR08_RS07740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSR08_RS07750	COG4347	Protein of unknown function (DUF1405)
BSR08_RS07755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BSR08_RS07755	COG2010	Cytochrome c
BSR08_RS07760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BSR08_RS07765	COG0723	plastoquinol--plastocyanin reductase activity
BSR08_RS07775	COG5582	Belongs to the UPF0302 family
BSR08_RS07780	COG0457	Tetratricopeptide repeat
BSR08_RS07785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BSR08_RS07790	COG0287	Prephenate dehydrogenase
BSR08_RS07805	COG0133	tryptophan synthase activity
BSR08_RS07810	COG0135	phosphoribosylanthranilate isomerase activity
BSR08_RS07820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BSR08_RS07825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BSR08_RS07830	COG4401	Chorismate mutase type I
BSR08_RS07835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BSR08_RS07840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BSR08_RS07845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BSR08_RS07850	COG0105	UTP biosynthetic process
BSR08_RS07855	COG0142	geranyltranstransferase activity
BSR08_RS07860	COG2226	methyltransferase
BSR08_RS07865	COG0142	geranyltranstransferase activity
BSR08_RS07875	COG0302	gtp cyclohydrolase
BSR08_RS07880	COG0776	regulation of translation
BSR08_RS07885	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BSR08_RS07900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BSR08_RS07905	COG1160	GTP binding
BSR08_RS07930	COG1304	FMN binding
BSR08_RS07935	COG0539	negative regulation of cytoplasmic translation
BSR08_RS07940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BSR08_RS07950	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BSR08_RS07955	COG2959	enzyme of heme biosynthesis
BSR08_RS07960	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS07960	COG3773	Cell wall hydrolase
BSR08_RS07965	COG2339	peptidase activity
BSR08_RS07970	COG0492	ferredoxin-NADP+ reductase activity
BSR08_RS07975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BSR08_RS07980	COG4862	establishment of competence for transformation
BSR08_RS07985	COG1408	metallophosphoesterase
BSR08_RS07995	COG1388	LysM domain
BSR08_RS08000	COG1266	CAAX protease self-immunity
BSR08_RS08005	COG0514	ATP-dependent DNA helicase (RecQ)
BSR08_RS08010	COG4955	Helix-turn-helix domain
BSR08_RS08015	COG1141	Ferredoxin
BSR08_RS08020	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BSR08_RS08025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BSR08_RS08030	COG0710	3-dehydroquinate dehydratase activity
BSR08_RS08040	COG1595	DNA-templated transcription, initiation
BSR08_RS08045	COG5002	protein histidine kinase activity
BSR08_RS08050	COG0745	RESPONSE REGULATOR receiver
BSR08_RS08055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSR08_RS08060	COG1333	cytochrome c biogenesis protein
BSR08_RS08065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR08_RS08070	COG1187	pseudouridine synthase activity
BSR08_RS08075	COG0700	Nucleoside recognition
BSR08_RS08080	COG2715	membrane protein required for spore maturation
BSR08_RS08085	COG1686	Belongs to the peptidase S11 family
BSR08_RS08095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BSR08_RS08100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BSR08_RS08105	COG1547	Domain of unknown function (DUF309)
BSR08_RS08110	COG0456	acetyltransferase
BSR08_RS08115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BSR08_RS08120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BSR08_RS08120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BSR08_RS08125	COG0307	riboflavin synthase, alpha
BSR08_RS08130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSR08_RS08130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSR08_RS08140	COG0681	Belongs to the peptidase S26 family
BSR08_RS08150	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BSR08_RS08160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BSR08_RS08165	COG0741	lytic transglycosylase activity
BSR08_RS08165	COG0739	heme binding
BSR08_RS08165	COG1196	nuclear chromosome segregation
BSR08_RS08200	COG3328	transposase activity
BSR08_RS08250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BSR08_RS08255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BSR08_RS08265	COG4086	secreted protein
BSR08_RS08270	COG0019	diaminopimelate decarboxylase activity
BSR08_RS08275	COG0697	spore germination
BSR08_RS08290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSR08_RS08310	COG1191	sigma factor activity
BSR08_RS08315	COG2172	sigma factor antagonist activity
BSR08_RS08320	COG1366	Belongs to the anti-sigma-factor antagonist family
BSR08_RS08325	COG1686	Belongs to the peptidase S11 family
BSR08_RS08330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BSR08_RS08335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BSR08_RS08340	COG4974	Belongs to the 'phage' integrase family
BSR08_RS08350	COG0735	belongs to the Fur family
BSR08_RS08355	COG1300	Membrane
BSR08_RS08365	COG0281	malic enzyme
BSR08_RS08370	COG1757	Na H antiporter
BSR08_RS08375	COG1027	Aspartate ammonia-lyase
BSR08_RS08380	COG0252	asparaginase activity
BSR08_RS08385	COG1396	sequence-specific DNA binding
BSR08_RS08390	COG1379	DNA repair
BSR08_RS08395	COG0494	nUDIX hydrolase
BSR08_RS08405	COG0667	Aldo Keto reductase
BSR08_RS08415	COG1073	alpha beta
BSR08_RS08425	COG4918	Iron-sulphur cluster biosynthesis
BSR08_RS08430	COG0456	acetyltransferase
BSR08_RS08430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BSR08_RS08435	COG2329	Antibiotic biosynthesis monooxygenase
BSR08_RS08440	COG0456	acetyltransferase
BSR08_RS08450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSR08_RS08460	COG2211	Major facilitator Superfamily
BSR08_RS08470	COG0346	lactoylglutathione lyase activity
BSR08_RS08475	COG1072	(Pantothenic acid kinase))
BSR08_RS08480	COG3048	D-serine ammonia-lyase activity
BSR08_RS08485	COG0300	oxidoreductase activity
BSR08_RS08490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSR08_RS08495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSR08_RS08500	COG4187	Peptidase family M20/M25/M40
BSR08_RS08505	COG1902	pentaerythritol trinitrate reductase activity
BSR08_RS08520	COG0596	Alpha beta hydrolase
BSR08_RS08530	COG1234	tRNA 3'-trailer cleavage
BSR08_RS08535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BSR08_RS08540	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BSR08_RS08545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSR08_RS08555	COG0706	membrane insertase activity
BSR08_RS08560	COG3361	conserved protein (COG2071)
BSR08_RS08565	COG2195	Cleaves the N-terminal amino acid of tripeptides
BSR08_RS08575	COG0346	lactoylglutathione lyase activity
BSR08_RS08580	COG1376	ErfK ybiS ycfS ynhG family protein
BSR08_RS08585	COG4129	membrane
BSR08_RS08590	COG1126	abc transporter atp-binding protein
BSR08_RS08595	COG0765	amino acid transport
BSR08_RS08600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR08_RS08610	COG1597	lipid kinase activity
BSR08_RS08620	COG4978	Transcriptional regulator
BSR08_RS08620	COG0789	Transcriptional regulator
BSR08_RS08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSR08_RS08630	COG0022	dehydrogenase e1 component
BSR08_RS08635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BSR08_RS08640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSR08_RS08645	COG3426	butyrate kinase activity
BSR08_RS08650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BSR08_RS08655	COG0280	phosphate acetyltransferase
BSR08_RS08660	COG3290	protein histidine kinase activity
BSR08_RS08660	COG3829	transcription factor binding
BSR08_RS08670	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BSR08_RS08675	COG2079	MmgE PrpD family protein
BSR08_RS08680	COG0372	Belongs to the citrate synthase family
BSR08_RS08685	COG1960	acyl-CoA dehydrogenase activity
BSR08_RS08690	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSR08_RS08695	COG0183	Belongs to the thiolase family
BSR08_RS08700	COG0584	glycerophosphoryl diester phosphodiesterase
BSR08_RS08705	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS08715	COG1902	pentaerythritol trinitrate reductase activity
BSR08_RS08720	COG0745	RESPONSE REGULATOR receiver
BSR08_RS08730	COG0750	zinc metalloprotease
BSR08_RS08735	COG0497	DNA recombination
BSR08_RS08740	COG1438	arginine binding
BSR08_RS08745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BSR08_RS08750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BSR08_RS08755	COG0142	geranyltranstransferase activity
BSR08_RS08760	COG1722	exodeoxyribonuclease VII activity
BSR08_RS08765	COG1570	exodeoxyribonuclease VII activity
BSR08_RS08770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BSR08_RS08775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSR08_RS08780	COG1302	Protein conserved in bacteria
BSR08_RS08785	COG0439	Biotin carboxylase
BSR08_RS08790	COG0511	ligase activity, forming carbon-carbon bonds
BSR08_RS08835	COG3854	ATPases associated with a variety of cellular activities
BSR08_RS08845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BSR08_RS08850	COG0006	proline dipeptidase activity
BSR08_RS08855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BSR08_RS08865	COG3872	metal-dependent enzyme
BSR08_RS08875	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSR08_RS08880	COG1321	iron dependent repressor
BSR08_RS08885	COG0095	Lipoate-protein ligase
BSR08_RS08890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSR08_RS08895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSR08_RS08900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSR08_RS08905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BSR08_RS08910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BSR08_RS08925	COG1396	sequence-specific DNA binding
BSR08_RS08935	COG0681	Belongs to the peptidase S26 family
BSR08_RS08960	COG4940	Competence protein ComGF
BSR08_RS08970	COG4970	Tfp pilus assembly protein FimT
BSR08_RS08975	COG4537	Required for transformation and DNA binding
BSR08_RS08980	COG1459	type II secretion system
BSR08_RS08985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BSR08_RS08990	COG0517	IMP dehydrogenase activity
BSR08_RS08995	COG0598	Magnesium transport protein CorA
BSR08_RS09000	COG1253	flavin adenine dinucleotide binding
BSR08_RS09005	COG1366	Belongs to the anti-sigma-factor antagonist family
BSR08_RS09015	COG1393	Belongs to the ArsC family
BSR08_RS09025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSR08_RS09035	COG0011	TIGRFAM Protein of
BSR08_RS09045	COG2866	Carboxypeptidase
BSR08_RS09050	COG1368	sulfuric ester hydrolase activity
BSR08_RS09055	COG1940	carbohydrate kinase activity
BSR08_RS09060	COG4483	Protein conserved in bacteria
BSR08_RS09065	COG0705	Rhomboid family
BSR08_RS09065	COG0457	Tetratricopeptide repeat
BSR08_RS09075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BSR08_RS09085	COG0438	transferase activity, transferring glycosyl groups
BSR08_RS09100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BSR08_RS09105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSR08_RS09110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSR08_RS09115	COG0581	inorganic phosphate transmembrane transporter activity
BSR08_RS09120	COG0573	inorganic phosphate transmembrane transporter activity
BSR08_RS09125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BSR08_RS09130	COG0768	penicillin binding
BSR08_RS09135	COG0477	Major facilitator Superfamily
BSR08_RS09140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BSR08_RS09145	COG2839	Protein conserved in bacteria
BSR08_RS09150	COG5521	maltodextrose utilization protein MalA
BSR08_RS09155	COG1388	LysM domain
BSR08_RS09160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BSR08_RS09165	COG4709	membrane
BSR08_RS09170	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BSR08_RS09175	COG0735	belongs to the Fur family
BSR08_RS09180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSR08_RS09190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BSR08_RS09195	COG0513	Belongs to the DEAD box helicase family
BSR08_RS09205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BSR08_RS09210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BSR08_RS09215	COG2384	SAM-dependent methyltransferase
BSR08_RS09220	COG2010	Cytochrome c
BSR08_RS09230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BSR08_RS09235	COG0358	DNA primase activity
BSR08_RS09240	COG1671	Belongs to the UPF0178 family
BSR08_RS09245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BSR08_RS09250	COG0517	IMP dehydrogenase activity
BSR08_RS09255	COG0751	glycine-tRNA ligase activity
BSR08_RS09260	COG0752	glycyl-tRNA synthetase alpha subunit
BSR08_RS09265	COG1381	Involved in DNA repair and RecF pathway recombination
BSR08_RS09275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BSR08_RS09280	COG0295	cytidine deaminase activity
BSR08_RS09285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BSR08_RS09290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BSR08_RS09295	COG1480	7TM receptor with intracellular HD hydrolase
BSR08_RS09300	COG1702	phosphate starvation-inducible protein PhoH
BSR08_RS09305	COG0561	phosphatase activity
BSR08_RS09320	COG4864	UPF0365 protein
BSR08_RS09325	COG1030	water channel activity
BSR08_RS09330	COG1610	YqeY-like protein
BSR08_RS09340	COG1283	sodium-dependent phosphate transmembrane transporter activity
BSR08_RS09345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BSR08_RS09350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BSR08_RS09355	COG2264	protein methyltransferase activity
BSR08_RS09360	COG0484	heat shock protein binding
BSR08_RS09365	COG0443	Heat shock 70 kDa protein
BSR08_RS09370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BSR08_RS09375	COG1420	regulation of RNA biosynthetic process
BSR08_RS09380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BSR08_RS09385	COG0481	GTPase activity
BSR08_RS09395	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS09400	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BSR08_RS09405	COG0268	Binds directly to 16S ribosomal RNA
BSR08_RS09410	COG1466	dna polymerase III delta subunit
BSR08_RS09420	COG0658	competence protein
BSR08_RS09420	COG2333	competence protein COMEC
BSR08_RS09425	COG2131	deaminase
BSR08_RS09430	COG1555	photosystem II stabilization
BSR08_RS09430	COG1596	polysaccharide export
BSR08_RS09435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSR08_RS09440	COG2226	methyltransferase
BSR08_RS09445	COG0799	negative regulation of ribosome biogenesis
BSR08_RS09450	COG1713	HD superfamily hydrolase involved in NAD metabolism
BSR08_RS09455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BSR08_RS09460	COG1534	Rna-binding protein
BSR08_RS09465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BSR08_RS09470	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BSR08_RS09475	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BSR08_RS09485	COG2755	lipolytic protein G-D-S-L family
BSR08_RS09490	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS09490	COG5632	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS09495	COG0398	Pfam SNARE associated Golgi protein
BSR08_RS09500	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BSR08_RS09510	COG3209	COG3209 Rhs family protein
BSR08_RS09525	COG0114	fumarate hydratase activity
BSR08_RS09530	COG0583	DNA-binding transcription factor activity
BSR08_RS09545	COG0457	Tetratricopeptide repeat
BSR08_RS09645	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BSR08_RS09650	COG1484	DNA-dependent DNA replication
BSR08_RS09665	COG4978	Transcriptional regulator
BSR08_RS09665	COG0789	Transcriptional regulator
BSR08_RS09670	COG2814	Major facilitator Superfamily
BSR08_RS09675	COG0456	acetyltransferase
BSR08_RS09680	COG1253	flavin adenine dinucleotide binding
BSR08_RS09690	COG0697	spore germination
BSR08_RS09695	COG0583	DNA-binding transcription factor activity
BSR08_RS09700	COG2072	flavoprotein involved in K transport
BSR08_RS09705	COG1230	cation diffusion facilitator family transporter
BSR08_RS09710	COG1942	4-Oxalocrotonate Tautomerase
BSR08_RS09715	COG1114	Component of the transport system for branched-chain amino acids
BSR08_RS09720	COG1687	branched-chain amino acid
BSR08_RS09730	COG1522	sequence-specific DNA binding
BSR08_RS09735	COG2732	(Barnase) inhibitor
BSR08_RS09740	COG2124	cytochrome p450
BSR08_RS09750	COG1335	isochorismatase
BSR08_RS09760	COG2318	DinB family
BSR08_RS09770	COG2070	2-Nitropropane dioxygenase
BSR08_RS09785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BSR08_RS09800	COG3443	Belongs to the bacterial solute-binding protein 9 family
BSR08_RS09805	COG1595	DNA-templated transcription, initiation
BSR08_RS09810	COG0667	Aldo Keto reductase
BSR08_RS09815	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS09820	COG5566	PFAM Mor transcription activator
BSR08_RS09825	COG0596	Alpha beta hydrolase
BSR08_RS09830	COG4991	sh3 domain protein
BSR08_RS09835	COG4991	sh3 domain protein
BSR08_RS09840	COG0346	lactoylglutathione lyase activity
BSR08_RS09850	COG5577	PFAM Coat F domain
BSR08_RS09855	COG1063	alcohol dehydrogenase
BSR08_RS09865	COG5577	PFAM Coat F domain
BSR08_RS09870	COG0789	Transcriptional regulator
BSR08_RS09880	COG1064	alcohol dehydrogenase
BSR08_RS09885	COG0693	protein deglycase activity
BSR08_RS09890	COG1621	beta-fructofuranosidase activity
BSR08_RS09895	COG3716	PTS system mannose fructose sorbose family IID component
BSR08_RS09900	COG3715	PTS system
BSR08_RS09905	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS09910	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR08_RS09915	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BSR08_RS09915	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BSR08_RS09920	COG1113	amino acid transport
BSR08_RS09925	COG1280	lysine exporter protein (LysE YggA)
BSR08_RS09930	COG1378	Sugar-specific transcriptional regulator TrmB
BSR08_RS09935	COG1595	DNA-templated transcription, initiation
BSR08_RS09960	COG1309	transcriptional regulator
BSR08_RS09965	COG2226	methyltransferase
BSR08_RS09975	COG2116	formate transmembrane transporter activity
BSR08_RS09980	COG5609	conserved protein (DUF2294)
BSR08_RS09985	COG3383	formate dehydrogenase (NAD+) activity
BSR08_RS09990	COG2427	Protein of unknown function (DUF1641)
BSR08_RS10005	COG0626	cystathionine gamma-synthase activity
BSR08_RS10010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSR08_RS10015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BSR08_RS10020	COG2226	methyltransferase
BSR08_RS10035	COG0768	penicillin binding
BSR08_RS10040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BSR08_RS10045	COG0572	uridine kinase
BSR08_RS10050	COG0826	peptidase U32
BSR08_RS10055	COG0826	peptidase U32
BSR08_RS10060	COG4122	O-methyltransferase activity
BSR08_RS10065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BSR08_RS10070	COG3906	Belongs to the UPF0473 family
BSR08_RS10075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BSR08_RS10080	COG4472	Bacterial protein of unknown function (DUF965)
BSR08_RS10085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BSR08_RS10090	COG0628	permease
BSR08_RS10095	COG1126	abc transporter atp-binding protein
BSR08_RS10100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR08_RS10105	COG0765	amino acid transport
BSR08_RS10110	COG0765	amino acid transport
BSR08_RS10125	COG3881	PFAM PRC-barrel domain
BSR08_RS10130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BSR08_RS10135	COG0457	Tetratricopeptide repeat
BSR08_RS10140	COG0482	sulfurtransferase activity
BSR08_RS10145	COG1104	cysteine desulfurase activity
BSR08_RS10150	COG1959	2 iron, 2 sulfur cluster binding
BSR08_RS10155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BSR08_RS10160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BSR08_RS10170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BSR08_RS10175	COG0124	histidyl-tRNA synthetase
BSR08_RS10185	COG3103	Sh3 type 3 domain protein
BSR08_RS10185	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS10185	COG4991	sh3 domain protein
BSR08_RS10195	COG1490	D-aminoacyl-tRNA deacylase activity
BSR08_RS10200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BSR08_RS10205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSR08_RS10210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BSR08_RS10210	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BSR08_RS10215	COG5416	Lipopolysaccharide assembly protein A domain
BSR08_RS10220	COG0490	domain, Protein
BSR08_RS10225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSR08_RS10225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSR08_RS10235	COG2244	polysaccharide biosynthetic process
BSR08_RS10240	COG2323	membrane
BSR08_RS10250	COG1862	Preprotein translocase
BSR08_RS10255	COG0343	queuine tRNA-ribosyltransferase activity
BSR08_RS10260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BSR08_RS10270	COG2255	four-way junction helicase activity
BSR08_RS10275	COG0632	four-way junction helicase activity
BSR08_RS10285	COG2814	Major facilitator Superfamily
BSR08_RS10290	COG0673	inositol 2-dehydrogenase activity
BSR08_RS10295	COG2112	serine threonine protein kinase
BSR08_RS10310	COG1115	amino acid carrier protein
BSR08_RS10315	COG0217	transcriptional regulatory protein
BSR08_RS10325	COG1388	LysM domain
BSR08_RS10330	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BSR08_RS10335	COG0157	Belongs to the NadC ModD family
BSR08_RS10340	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BSR08_RS10345	COG1104	cysteine desulfurase activity
BSR08_RS10350	COG1827	regulation of RNA biosynthetic process
BSR08_RS10355	COG0077	Prephenate dehydratase
BSR08_RS10360	COG4492	Belongs to the UPF0735 family
BSR08_RS10365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BSR08_RS10370	COG3290	protein histidine kinase activity
BSR08_RS10375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BSR08_RS10380	COG2868	ribosomal protein
BSR08_RS10385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BSR08_RS10390	COG1994	Peptidase M50
BSR08_RS10395	COG0739	heme binding
BSR08_RS10400	COG2894	cell division
BSR08_RS10405	COG0850	regulation of cytokinetic process
BSR08_RS10410	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BSR08_RS10420	COG1077	Cell shape determining protein MreB Mrl
BSR08_RS10425	COG2003	Belongs to the UPF0758 family
BSR08_RS10430	COG0424	maF-like protein
BSR08_RS10440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BSR08_RS10445	COG0285	dihydrofolate synthase activity
BSR08_RS10450	COG0525	valine-tRNA ligase activity
BSR08_RS10460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSR08_RS10465	COG1388	LysM domain
BSR08_RS10470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BSR08_RS10475	COG0113	porphobilinogen synthase activity
BSR08_RS10480	COG1587	Uroporphyrinogen-III synthase
BSR08_RS10485	COG0181	hydroxymethylbilane synthase activity
BSR08_RS10490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSR08_RS10495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BSR08_RS10505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BSR08_RS10510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BSR08_RS10515	COG1067	ATP-dependent peptidase activity
BSR08_RS10515	COG0470	DNA polymerase III
BSR08_RS10520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BSR08_RS10525	COG0544	peptidyl-prolyl cis-trans isomerase activity
BSR08_RS10530	COG0457	Tetratricopeptide repeat
BSR08_RS10530	COG1477	protein flavinylation
BSR08_RS10535	COG0066	3-isopropylmalate dehydratase activity
BSR08_RS10540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BSR08_RS10545	COG0473	3-isopropylmalate dehydrogenase activity
BSR08_RS10550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSR08_RS10555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BSR08_RS10560	COG0440	acetolactate synthase activity
BSR08_RS10565	COG0028	Belongs to the TPP enzyme family
BSR08_RS10575	COG0454	-acetyltransferase
BSR08_RS10580	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BSR08_RS10590	COG2801	Transposase and inactivated derivatives
BSR08_RS10615	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BSR08_RS10640	COG0622	Phosphoesterase
BSR08_RS10645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BSR08_RS10650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BSR08_RS10655	COG5401	PFAM Sporulation and spore germination
BSR08_RS10660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BSR08_RS10665	COG1846	Transcriptional regulator
BSR08_RS10670	COG2197	response regulator
BSR08_RS10675	COG0824	Thioesterase
BSR08_RS10680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BSR08_RS10685	COG1053	succinate dehydrogenase
BSR08_RS10690	COG2009	succinate dehydrogenase
BSR08_RS10695	COG1719	4-vinyl reductase, 4VR
BSR08_RS10700	COG0527	aspartate kinase activity
BSR08_RS10710	COG0322	excinuclease ABC activity
BSR08_RS10715	COG3118	belongs to the thioredoxin family
BSR08_RS10720	COG3534	alpha-L-arabinofuranosidase
BSR08_RS10725	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BSR08_RS10730	COG2086	electron transfer activity
BSR08_RS10735	COG1024	Enoyl-CoA hydratase
BSR08_RS10740	COG1309	transcriptional regulator
BSR08_RS10745	COG0318	PFAM AMP-dependent synthetase and ligase
BSR08_RS10750	COG3766	membrane
BSR08_RS10755	COG1193	negative regulation of DNA recombination
BSR08_RS10760	COG1796	DNA polymerase
BSR08_RS10760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BSR08_RS10765	COG1286	toxin biosynthetic process
BSR08_RS10770	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BSR08_RS10775	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BSR08_RS10780	COG0072	phenylalanine-tRNA ligase activity
BSR08_RS10780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSR08_RS10785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BSR08_RS10795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSR08_RS10805	COG3835	regulator
BSR08_RS10810	COG0277	FAD linked oxidase domain protein
BSR08_RS10815	COG0247	lactate metabolic process
BSR08_RS10820	COG0346	lactoylglutathione lyase activity
BSR08_RS10825	COG1966	Carbon starvation protein
BSR08_RS10830	COG3534	alpha-L-arabinofuranosidase
BSR08_RS10835	COG0395	ABC-type sugar transport system, permease component
BSR08_RS10840	COG1175	transmembrane transport
BSR08_RS10845	COG1653	transport
BSR08_RS10850	COG0371	Dehydrogenase
BSR08_RS10855	COG0647	UMP catabolic process
BSR08_RS10860	COG0235	Class ii aldolase
BSR08_RS10865	COG1069	ribulokinase activity
BSR08_RS10870	COG2160	L-arabinose isomerase activity
BSR08_RS10880	COG1363	Peptidase, m42
BSR08_RS10890	COG3326	Membrane
BSR08_RS10895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BSR08_RS10900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BSR08_RS10905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BSR08_RS10915	COG1346	cytolysis
BSR08_RS10920	COG1380	Effector of murein hydrolase LrgA
BSR08_RS10925	COG3279	Response regulator of the LytR AlgR family
BSR08_RS10930	COG3275	phosphorelay sensor kinase activity
BSR08_RS10935	COG1011	Hydrolase
BSR08_RS10940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BSR08_RS10950	COG0398	Pfam SNARE associated Golgi protein
BSR08_RS10955	COG1484	DNA-dependent DNA replication
BSR08_RS10960	COG3611	Membrane attachment protein
BSR08_RS10965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BSR08_RS10970	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BSR08_RS10975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BSR08_RS10980	COG1733	regulation of RNA biosynthetic process
BSR08_RS10985	COG2814	Major facilitator Superfamily
BSR08_RS10990	COG0656	L-ascorbic acid biosynthetic process
BSR08_RS10995	COG0237	dephospho-CoA kinase activity
BSR08_RS11000	COG1971	Probably functions as a manganese efflux pump
BSR08_RS11005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BSR08_RS11010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSR08_RS11010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSR08_RS11015	COG5002	protein histidine kinase activity
BSR08_RS11020	COG0745	RESPONSE REGULATOR receiver
BSR08_RS11025	COG0039	L-malate dehydrogenase activity
BSR08_RS11030	COG0538	isocitrate dehydrogenase activity
BSR08_RS11035	COG0372	Belongs to the citrate synthase family
BSR08_RS11040	COG2707	UPF0756 membrane protein
BSR08_RS11045	COG0628	permease
BSR08_RS11050	COG3030	protein affecting phage T7 exclusion by the F plasmid
BSR08_RS11055	COG0469	pyruvate kinase activity
BSR08_RS11060	COG0205	6-phosphofructokinase activity
BSR08_RS11065	COG0825	malonyl-CoA metabolic process
BSR08_RS11070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BSR08_RS11075	COG0281	malic enzyme
BSR08_RS11080	COG0587	DNA-directed DNA polymerase activity
BSR08_RS11100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BSR08_RS11110	COG4109	DRTGG domain
BSR08_RS11120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BSR08_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS11135	COG0165	Argininosuccinate lyase
BSR08_RS11140	COG0137	argininosuccinate synthase activity
BSR08_RS11145	COG0521	Mo-molybdopterin cofactor biosynthetic process
BSR08_RS11150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BSR08_RS11160	COG0827	DNA restriction-modification system
BSR08_RS11165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BSR08_RS11170	COG3874	Sporulation protein YtfJ
BSR08_RS11180	COG1714	RDD family
BSR08_RS11185	COG0616	signal peptide processing
BSR08_RS11190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BSR08_RS11195	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BSR08_RS11200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSR08_RS11210	COG0301	tRNA thio-modification
BSR08_RS11215	COG1104	cysteine desulfurase activity
BSR08_RS11220	COG1114	Component of the transport system for branched-chain amino acids
BSR08_RS11225	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BSR08_RS11230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BSR08_RS11235	COG1309	transcriptional regulator
BSR08_RS11240	COG1956	GAF domain-containing protein
BSR08_RS11245	COG2203	Gaf domain
BSR08_RS11245	COG2199	diguanylate cyclase activity
BSR08_RS11255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BSR08_RS11260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BSR08_RS11270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSR08_RS11275	COG0454	-acetyltransferase
BSR08_RS11280	COG0517	IMP dehydrogenase activity
BSR08_RS11285	COG0123	including yeast histone deacetylase and acetoin utilization protein
BSR08_RS11290	COG1360	Flagellar Motor Protein
BSR08_RS11295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BSR08_RS11300	COG1609	Transcriptional regulator
BSR08_RS11305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BSR08_RS11305	COG1605	Chorismate mutase
BSR08_RS11310	COG3118	belongs to the thioredoxin family
BSR08_RS11315	COG4980	gas vesicle protein
BSR08_RS11320	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BSR08_RS11325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BSR08_RS11330	COG1674	ftsk spoiiie
BSR08_RS11335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSR08_RS11340	COG4848	Belongs to the UPF0354 family
BSR08_RS11345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR08_RS11355	COG1363	Peptidase, m42
BSR08_RS11360	COG5584	Small secreted protein
BSR08_RS11365	COG0281	malic enzyme
BSR08_RS11370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSR08_RS11375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BSR08_RS11385	COG0510	thiamine kinase activity
BSR08_RS11390	COG1523	belongs to the glycosyl hydrolase 13 family
BSR08_RS11395	COG1597	lipid kinase activity
BSR08_RS11405	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BSR08_RS11410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSR08_RS11415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSR08_RS11420	COG2252	PERMEase
BSR08_RS11425	COG4473	ABC transporter
BSR08_RS11430	COG1131	(ABC) transporter
BSR08_RS11435	COG1349	DNA-binding transcription factor activity
BSR08_RS11440	COG1187	pseudouridine synthase activity
BSR08_RS11445	COG2244	polysaccharide biosynthetic process
BSR08_RS11450	COG2081	HI0933 family
BSR08_RS11455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BSR08_RS11465	COG5578	integral membrane protein
BSR08_RS11475	COG1653	transport
BSR08_RS11480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BSR08_RS11485	COG4209	transmembrane transport
BSR08_RS11495	COG1653	transport
BSR08_RS11500	COG0395	ABC-type sugar transport system, permease component
BSR08_RS11505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BSR08_RS11510	COG2124	cytochrome p450
BSR08_RS11530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BSR08_RS11535	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
BSR08_RS11540	COG1073	alpha beta
BSR08_RS11545	COG1609	Transcriptional regulator
BSR08_RS11550	COG1653	transport
BSR08_RS11555	COG1175	transmembrane transport
BSR08_RS11560	COG0395	ABC-type sugar transport system, permease component
BSR08_RS11565	COG1486	melibiose metabolic process
BSR08_RS11570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSR08_RS11575	COG0495	leucyl-tRNA aminoacylation
BSR08_RS11585	COG2202	Pas domain
BSR08_RS11585	COG1366	Belongs to the anti-sigma-factor antagonist family
BSR08_RS11590	COG2814	Major facilitator Superfamily
BSR08_RS11595	COG2433	Pfam Transposase IS66
BSR08_RS11600	COG0577	efflux transmembrane transporter activity
BSR08_RS11605	COG1136	(ABC) transporter
BSR08_RS11610	COG2205	protein histidine kinase activity
BSR08_RS11615	COG0745	RESPONSE REGULATOR receiver
BSR08_RS11620	COG0577	efflux transmembrane transporter activity
BSR08_RS11625	COG1136	(ABC) transporter
BSR08_RS11640	COG1131	(ABC) transporter
BSR08_RS11645	COG1725	Transcriptional regulator
BSR08_RS11655	COG1242	4 iron, 4 sulfur cluster binding
BSR08_RS11660	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BSR08_RS11670	COG2267	carboxylic ester hydrolase activity
BSR08_RS11675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BSR08_RS11680	COG1113	amino acid transport
BSR08_RS11685	COG0367	asparagine synthase
BSR08_RS11690	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BSR08_RS11695	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BSR08_RS11705	COG1506	peptidase
BSR08_RS11710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSR08_RS11715	COG1116	anion transmembrane transporter activity
BSR08_RS11720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSR08_RS11725	COG0494	nUDIX hydrolase
BSR08_RS11730	COG4824	toxin secretion phage lysis holin
BSR08_RS11735	COG0783	Belongs to the Dps family
BSR08_RS11750	COG1854	S-ribosylhomocysteine lyase activity
BSR08_RS11755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BSR08_RS11760	COG0288	reversible hydration of carbon dioxide
BSR08_RS11765	COG0254	rRNA binding
BSR08_RS11770	COG1271	oxidase subunit
BSR08_RS11775	COG1294	oxidase, subunit
BSR08_RS11785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BSR08_RS11790	COG1321	iron dependent repressor
BSR08_RS11790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BSR08_RS11795	COG1121	(ABC) transporter
BSR08_RS11800	COG0803	Belongs to the bacterial solute-binding protein 9 family
BSR08_RS11805	COG4948	Mandelate Racemase Muconate Lactonizing
BSR08_RS11810	COG0318	PFAM AMP-dependent synthetase and ligase
BSR08_RS11815	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BSR08_RS11820	COG0596	Alpha beta hydrolase
BSR08_RS11825	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BSR08_RS11830	COG1169	isochorismate synthase
BSR08_RS11835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BSR08_RS11840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSR08_RS11845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BSR08_RS11850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BSR08_RS11855	COG0438	transferase activity, transferring glycosyl groups
BSR08_RS11865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSR08_RS11870	COG0438	transferase activity, transferring glycosyl groups
BSR08_RS11875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSR08_RS11880	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BSR08_RS11885	COG0058	SHG alpha-glucan phosphorylase activity
BSR08_RS11890	COG0297	glycogen (starch) synthase activity
BSR08_RS11895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BSR08_RS11900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BSR08_RS11905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BSR08_RS12030	COG3859	Proton-coupled thiamine transporter YuaJ
BSR08_RS12035	COG1247	-acetyltransferase
BSR08_RS12040	COG2268	Band 7 protein
BSR08_RS12045	COG1585	Membrane protein implicated in regulation of membrane protease activity
BSR08_RS12050	COG2318	DinB family
BSR08_RS12060	COG1454	alcohol dehydrogenase
BSR08_RS12065	COG1012	belongs to the aldehyde dehydrogenase family
BSR08_RS12070	COG1510	regulation of RNA biosynthetic process
BSR08_RS12080	COG0569	domain protein
BSR08_RS12085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BSR08_RS12090	COG4682	membrane
BSR08_RS12095	COG1705	Flagellar rod assembly protein muramidase FlgJ
BSR08_RS12100	COG0477	Major facilitator Superfamily
BSR08_RS12105	COG5553	Cysteine dioxygenase type I
BSR08_RS12115	COG1968	undecaprenyl-diphosphatase activity
BSR08_RS12120	COG0628	permease
BSR08_RS12125	COG0673	inositol 2-dehydrogenase activity
BSR08_RS12130	COG4806	L-rhamnose isomerase
BSR08_RS12135	COG3254	rhamnose metabolic process
BSR08_RS12140	COG1070	Carbohydrate kinase
BSR08_RS12145	COG1349	DNA-binding transcription factor activity
BSR08_RS12150	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS12150	COG3347	Dehydrogenase
BSR08_RS12165	COG0840	transmembrane signaling receptor activity
BSR08_RS12175	COG0840	transmembrane signaling receptor activity
BSR08_RS12190	COG0432	Pfam Uncharacterised protein family UPF0047
BSR08_RS12195	COG0366	Alpha amylase catalytic
BSR08_RS12200	COG1253	flavin adenine dinucleotide binding
BSR08_RS12205	COG2738	Putative neutral zinc metallopeptidase
BSR08_RS12220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BSR08_RS12235	COG0166	Belongs to the GPI family
BSR08_RS12240	COG1979	alcohol dehydrogenase
BSR08_RS12245	COG1979	alcohol dehydrogenase
BSR08_RS12250	COG2155	Conserved Protein
BSR08_RS12255	COG1098	S1 RNA binding domain
BSR08_RS12260	COG0436	Aminotransferase
BSR08_RS12265	COG1522	sequence-specific DNA binding
BSR08_RS12270	COG2267	carboxylic ester hydrolase activity
BSR08_RS12280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BSR08_RS12285	COG2205	protein histidine kinase activity
BSR08_RS12295	COG5018	Exonuclease
BSR08_RS12305	COG2814	Major facilitator Superfamily
BSR08_RS12310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSR08_RS12315	COG3011	Protein conserved in bacteria
BSR08_RS12325	COG3290	protein histidine kinase activity
BSR08_RS12330	COG4565	transcriptional regulatory protein
BSR08_RS12335	COG1744	ABC transporter substrate-binding protein PnrA-like
BSR08_RS12340	COG3845	ABC transporter
BSR08_RS12345	COG4603	Belongs to the binding-protein-dependent transport system permease family
BSR08_RS12350	COG1079	Belongs to the binding-protein-dependent transport system permease family
BSR08_RS12355	COG3493	citrate carrier protein
BSR08_RS12365	COG2111	Na H antiporter
BSR08_RS12365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BSR08_RS12370	COG2111	Na H antiporter
BSR08_RS12375	COG1006	Multisubunit Na H antiporter MnhC subunit
BSR08_RS12380	COG0651	ATP synthesis coupled electron transport
BSR08_RS12385	COG1863	multisubunit Na H antiporter MnhE subunit
BSR08_RS12390	COG2212	antiporter activity
BSR08_RS12395	COG1320	monovalent cation:proton antiporter activity
BSR08_RS12400	COG2050	protein possibly involved in aromatic compounds catabolism
BSR08_RS12405	COG2197	response regulator
BSR08_RS12410	COG4585	Histidine kinase
BSR08_RS12420	COG0142	geranyltranstransferase activity
BSR08_RS12435	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BSR08_RS12440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BSR08_RS12445	COG1335	isochorismatase
BSR08_RS12450	COG5506	Protein of unknown function (DUF1694)
BSR08_RS12465	COG0628	permease
BSR08_RS12480	COG1418	mRNA catabolic process
BSR08_RS12485	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS12495	COG1511	domain protein
BSR08_RS12500	COG1674	ftsk spoiiie
BSR08_RS12500	COG0433	COG0433 Predicted ATPase
BSR08_RS12505	COG4499	WXG100 protein secretion system (Wss), protein YukC
BSR08_RS12510	COG5417	Belongs to the EsaB family
BSR08_RS12515	COG4842	Belongs to the WXG100 family
BSR08_RS12525	COG2508	Transcriptional regulator
BSR08_RS12525	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BSR08_RS12530	COG0686	Belongs to the AlaDH PNT family
BSR08_RS12535	COG5634	Uncharacterized conserved protein (DUF2278)
BSR08_RS12540	COG3251	PFAM MbtH domain protein
BSR08_RS12545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BSR08_RS12550	COG1535	isochorismatase
BSR08_RS12550	COG3433	isochorismatase activity
BSR08_RS12555	COG1021	2,3-dihydroxybenzoate-AMP ligase
BSR08_RS12560	COG1169	isochorismate synthase
BSR08_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS12570	COG2819	hydrolase of the alpha beta superfamily
BSR08_RS12575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BSR08_RS12580	COG1268	BioY protein
BSR08_RS12585	COG2056	Na+-H+ antiporter family
BSR08_RS12590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BSR08_RS12595	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BSR08_RS12600	COG3584	3D domain protein
BSR08_RS12615	COG1252	NADH dehydrogenase
BSR08_RS12620	COG0492	ferredoxin-NADP+ reductase activity
BSR08_RS12630	COG0516	GMP reductase activity
BSR08_RS12635	COG2808	Putative FMN-binding domain
BSR08_RS12640	COG0456	acetyltransferase
BSR08_RS12735	COG0582	viral genome integration into host DNA
BSR08_RS12745	COG4974	Belongs to the 'phage' integrase family
BSR08_RS12750	COG0316	Belongs to the HesB IscA family
BSR08_RS12755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BSR08_RS12760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSR08_RS12765	COG4844	belongs to the
BSR08_RS12770	COG1252	NADH dehydrogenase
BSR08_RS12775	COG4837	Protein of unknown function (DUF1462)
BSR08_RS12780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BSR08_RS12785	COG0823	Involved in the tonB-independent uptake of proteins
BSR08_RS12785	COG4946	Tricorn protease homolog
BSR08_RS12785	COG1506	peptidase
BSR08_RS12790	COG0083	homoserine kinase activity
BSR08_RS12795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BSR08_RS12800	COG0460	homoserine dehydrogenase
BSR08_RS12805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSR08_RS12810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BSR08_RS12815	COG0647	UMP catabolic process
BSR08_RS12820	COG2445	Protein of unknown function DUF86
BSR08_RS12825	COG4470	Protein conserved in bacteria
BSR08_RS12835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BSR08_RS12840	COG0739	heme binding
BSR08_RS12850	COG3377	Domain of unknown function (DUF1805)
BSR08_RS12855	COG0737	Belongs to the 5'-nucleotidase family
BSR08_RS12860	COG0730	response to heat
BSR08_RS12865	COG1801	Protein of unknown function DUF72
BSR08_RS12875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BSR08_RS12880	COG2508	Transcriptional regulator
BSR08_RS12885	COG2233	PERMEase
BSR08_RS12890	COG2233	PERMEase
BSR08_RS12895	COG3648	Uricase
BSR08_RS12895	COG3195	allantoin biosynthetic process
BSR08_RS12900	COG2351	hydroxyisourate hydrolase activity
BSR08_RS12910	COG2080	2 iron, 2 sulfur cluster binding
BSR08_RS12915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BSR08_RS12920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BSR08_RS12925	COG2068	MobA-Related Protein
BSR08_RS12930	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BSR08_RS12935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BSR08_RS12940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSR08_RS12945	COG2356	endonuclease I
BSR08_RS12950	COG3842	ATPase activity
BSR08_RS12955	COG2188	Transcriptional regulator
BSR08_RS12960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSR08_RS12970	COG1175	transmembrane transport
BSR08_RS12975	COG1653	transport
BSR08_RS12980	COG2222	sugar isomerase
BSR08_RS12985	COG0322	excinuclease ABC activity
BSR08_RS12990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSR08_RS13005	COG0346	lactoylglutathione lyase activity
BSR08_RS13010	COG0640	Transcriptional regulator
BSR08_RS13015	COG0719	Fe-S assembly protein
BSR08_RS13020	COG0822	iron-sulfur transferase activity
BSR08_RS13025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BSR08_RS13030	COG0719	Fe-S assembly protein
BSR08_RS13035	COG0396	ATPase activity
BSR08_RS13055	COG1464	Belongs to the NlpA lipoprotein family
BSR08_RS13060	COG2011	ABC-type metal ion transport system permease component
BSR08_RS13065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BSR08_RS13075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR08_RS13080	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BSR08_RS13090	COG0509	glycine decarboxylation via glycine cleavage system
BSR08_RS13095	COG1393	Belongs to the ArsC family
BSR08_RS13100	COG1960	acyl-CoA dehydrogenase activity
BSR08_RS13105	COG0183	Belongs to the thiolase family
BSR08_RS13110	COG1024	Enoyl-CoA hydratase
BSR08_RS13110	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSR08_RS13130	COG5577	PFAM Coat F domain
BSR08_RS13135	COG1846	Transcriptional regulator
BSR08_RS13140	COG0477	Major facilitator Superfamily
BSR08_RS13145	COG1942	4-Oxalocrotonate Tautomerase
BSR08_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS13155	COG0583	DNA-binding transcription factor activity
BSR08_RS13165	COG1120	ATPase activity
BSR08_RS13185	COG1131	(ABC) transporter
BSR08_RS13235	COG0783	Belongs to the Dps family
BSR08_RS13240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSR08_RS13245	COG0745	RESPONSE REGULATOR receiver
BSR08_RS13250	COG2205	protein histidine kinase activity
BSR08_RS13250	COG2770	Histidine kinase
BSR08_RS13260	COG1309	transcriptional regulator
BSR08_RS13265	COG0114	fumarate hydratase activity
BSR08_RS13275	COG0697	spore germination
BSR08_RS13280	COG0814	amino acid
BSR08_RS13290	COG2197	response regulator
BSR08_RS13295	COG4585	Histidine kinase
BSR08_RS13300	COG4758	membrane
BSR08_RS13305	COG3595	metallopeptidase activity
BSR08_RS13310	COG1842	Phage shock protein A
BSR08_RS13315	COG4758	membrane
BSR08_RS13320	COG2814	Major facilitator Superfamily
BSR08_RS13325	COG2096	Adenosyltransferase
BSR08_RS13330	COG1120	ATPase activity
BSR08_RS13335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR08_RS13340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSR08_RS13345	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS13350	COG3386	PFAM SMP-30 Gluconolaconase
BSR08_RS13355	COG2205	protein histidine kinase activity
BSR08_RS13360	COG0745	RESPONSE REGULATOR receiver
BSR08_RS13370	COG1191	sigma factor activity
BSR08_RS13380	COG2140	Oxalate decarboxylase
BSR08_RS13390	COG0577	efflux transmembrane transporter activity
BSR08_RS13395	COG1136	(ABC) transporter
BSR08_RS13400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSR08_RS13405	COG1120	ATPase activity
BSR08_RS13410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR08_RS13415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR08_RS13420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSR08_RS13430	COG0531	amino acid
BSR08_RS13445	COG1988	membrane-bound metal-dependent
BSR08_RS13450	COG1368	sulfuric ester hydrolase activity
BSR08_RS13455	COG1910	domain protein
BSR08_RS13460	COG0725	ABC transporter, periplasmic molybdate-binding protein
BSR08_RS13465	COG4149	molybdate abc transporter
BSR08_RS13470	COG0656	L-ascorbic acid biosynthetic process
BSR08_RS13480	COG0025	NhaP-type Na H and K H
BSR08_RS13485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BSR08_RS13490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BSR08_RS13495	COG3973	AAA domain
BSR08_RS13505	COG2860	membrane
BSR08_RS13510	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BSR08_RS13515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BSR08_RS13520	COG2217	Heavy metal translocating P-type atpase
BSR08_RS13525	COG2217	Heavy metal translocating P-type atpase
BSR08_RS13530	COG2608	mercury ion transmembrane transporter activity
BSR08_RS13535	COG1937	Protein conserved in bacteria
BSR08_RS13540	COG0673	inositol 2-dehydrogenase activity
BSR08_RS13550	COG1289	transmembrane transporter activity
BSR08_RS13560	COG2076	Multidrug Resistance protein
BSR08_RS13565	COG1309	transcriptional regulator
BSR08_RS13570	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS13580	COG5444	nuclease activity
BSR08_RS13595	COG5632	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS13595	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS13600	COG4824	toxin secretion phage lysis holin
BSR08_RS13625	COG1705	Flagellar rod assembly protein muramidase FlgJ
BSR08_RS13625	COG3942	CHAP domain
BSR08_RS13850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BSR08_RS13855	COG0557	exoribonuclease II activity
BSR08_RS13860	COG1647	Serine aminopeptidase, S33
BSR08_RS13865	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BSR08_RS13870	COG0596	Alpha beta hydrolase
BSR08_RS13875	COG1476	TRANSCRIPTIONal
BSR08_RS13880	COG1396	sequence-specific DNA binding
BSR08_RS13885	COG1396	sequence-specific DNA binding
BSR08_RS13890	COG1733	regulation of RNA biosynthetic process
BSR08_RS13895	COG0840	transmembrane signaling receptor activity
BSR08_RS13900	COG1174	glycine betaine transport
BSR08_RS13905	COG1732	Glycine betaine
BSR08_RS13910	COG1174	glycine betaine transport
BSR08_RS13915	COG1125	glycine betaine transport
BSR08_RS13915	COG0517	IMP dehydrogenase activity
BSR08_RS13920	COG1510	regulation of RNA biosynthetic process
BSR08_RS13925	COG1174	glycine betaine transport
BSR08_RS13930	COG1732	Glycine betaine
BSR08_RS13935	COG1174	glycine betaine transport
BSR08_RS13940	COG0517	IMP dehydrogenase activity
BSR08_RS13940	COG1125	glycine betaine transport
BSR08_RS13945	COG1510	regulation of RNA biosynthetic process
BSR08_RS13950	COG2095	MarC family integral membrane protein
BSR08_RS13960	COG3064	Membrane
BSR08_RS13965	COG4640	response to antibiotic
BSR08_RS13970	COG0456	acetyltransferase
BSR08_RS13975	COG0148	phosphopyruvate hydratase activity
BSR08_RS13980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BSR08_RS13985	COG0149	triose-phosphate isomerase activity
BSR08_RS13990	COG0126	phosphoglycerate kinase activity
BSR08_RS13995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BSR08_RS14000	COG2390	Transcriptional regulator
BSR08_RS14005	COG2814	Major facilitator Superfamily
BSR08_RS14010	COG1609	Transcriptional regulator
BSR08_RS14015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSR08_RS14025	COG0583	DNA-binding transcription factor activity
BSR08_RS14030	COG0697	spore germination
BSR08_RS14035	COG1113	amino acid transport
BSR08_RS14045	COG1556	Lactate utilization protein
BSR08_RS14050	COG1139	Iron-sulfur cluster binding protein
BSR08_RS14055	COG0247	lactate metabolic process
BSR08_RS14060	COG2197	response regulator
BSR08_RS14065	COG4585	Histidine kinase
BSR08_RS14070	COG0842	Transport permease protein
BSR08_RS14075	COG1131	(ABC) transporter
BSR08_RS14095	COG0596	Alpha beta hydrolase
BSR08_RS14100	COG2208	phosphoserine phosphatase activity
BSR08_RS14105	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BSR08_RS14110	COG1874	Beta-galactosidase
BSR08_RS14115	COG3833	ABC-type maltose transport systems, permease component
BSR08_RS14120	COG1175	transmembrane transport
BSR08_RS14125	COG2182	Extracellular solute-binding protein
BSR08_RS14130	COG1609	Transcriptional regulator
BSR08_RS14135	COG2186	Transcriptional regulator
BSR08_RS14140	COG1620	l-lactate permease
BSR08_RS14145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BSR08_RS14155	COG5039	Polysaccharide pyruvyl transferase
BSR08_RS14160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BSR08_RS14165	COG0110	maltose O-acetyltransferase activity
BSR08_RS14170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BSR08_RS14175	COG2244	polysaccharide biosynthetic process
BSR08_RS14180	COG1216	Glycosyl transferase, family 2
BSR08_RS14185	COG5039	Polysaccharide pyruvyl transferase
BSR08_RS14190	COG1216	Glycosyl transferase, family 2
BSR08_RS14200	COG0438	transferase activity, transferring glycosyl groups
BSR08_RS14205	COG1215	transferase activity, transferring glycosyl groups
BSR08_RS14210	COG0438	transferase activity, transferring glycosyl groups
BSR08_RS14215	COG1086	Polysaccharide biosynthesis protein
BSR08_RS14220	COG0489	protein tyrosine kinase activity
BSR08_RS14225	COG3944	biosynthesis protein
BSR08_RS14230	COG1396	sequence-specific DNA binding
BSR08_RS14235	COG2272	Belongs to the type-B carboxylesterase lipase family
BSR08_RS14245	COG3479	Phenolic acid decarboxylase
BSR08_RS14260	COG1794	racemase activity, acting on amino acids and derivatives
BSR08_RS14270	COG1621	beta-fructofuranosidase activity
BSR08_RS14275	COG1621	beta-fructofuranosidase activity
BSR08_RS14280	COG0531	amino acid
BSR08_RS14285	COG1309	transcriptional regulator
BSR08_RS14290	COG2076	Multidrug Resistance protein
BSR08_RS14295	COG2076	Multidrug Resistance protein
BSR08_RS14315	COG1674	ftsk spoiiie
BSR08_RS14335	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS14335	COG1388	LysM domain
BSR08_RS14335	COG5632	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS14370	COG1705	Flagellar rod assembly protein muramidase FlgJ
BSR08_RS14450	COG0582	viral genome integration into host DNA
BSR08_RS14550	COG4974	Belongs to the 'phage' integrase family
BSR08_RS14560	COG0740	serine-type endopeptidase activity
BSR08_RS14565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BSR08_RS14570	COG0366	Alpha amylase catalytic
BSR08_RS14575	COG1554	hydrolase, family 65, central catalytic
BSR08_RS14580	COG5521	maltodextrose utilization protein MalA
BSR08_RS14585	COG3833	ABC-type maltose transport systems, permease component
BSR08_RS14590	COG1175	transmembrane transport
BSR08_RS14595	COG2182	Extracellular solute-binding protein
BSR08_RS14605	COG1609	Transcriptional regulator
BSR08_RS14610	COG1611	Belongs to the LOG family
BSR08_RS14620	COG0659	secondary active sulfate transmembrane transporter activity
BSR08_RS14625	COG0288	reversible hydration of carbon dioxide
BSR08_RS14630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSR08_RS14635	COG0577	efflux transmembrane transporter activity
BSR08_RS14640	COG1136	(ABC) transporter
BSR08_RS14645	COG5002	protein histidine kinase activity
BSR08_RS14650	COG0745	RESPONSE REGULATOR receiver
BSR08_RS14660	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BSR08_RS14665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR08_RS14670	COG1481	regulation of sporulation
BSR08_RS14675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BSR08_RS14680	COG1660	Displays ATPase and GTPase activities
BSR08_RS14685	COG1051	belongs to the nudix hydrolase family
BSR08_RS14690	COG0492	ferredoxin-NADP+ reductase activity
BSR08_RS14695	COG0791	NLP P60 protein
BSR08_RS14695	COG3883	PFAM NLP P60 protein
BSR08_RS14700	COG0457	Tetratricopeptide repeat
BSR08_RS14705	COG1132	(ABC) transporter
BSR08_RS14725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BSR08_RS14725	COG0140	phosphoribosyl-ATP diphosphatase activity
BSR08_RS14730	COG0107	imidazoleglycerol-phosphate synthase activity
BSR08_RS14735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BSR08_RS14740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BSR08_RS14745	COG0131	Imidazoleglycerol-phosphate dehydratase
BSR08_RS14750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BSR08_RS14755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BSR08_RS14760	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BSR08_RS14765	COG4990	cell redox homeostasis
BSR08_RS14770	COG5297	Belongs to the glycosyl hydrolase family 6
BSR08_RS14780	COG2801	Transposase and inactivated derivatives
BSR08_RS14790	COG0546	phosphoglycolate phosphatase activity
BSR08_RS14795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BSR08_RS14800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BSR08_RS14805	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BSR08_RS14810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BSR08_RS14815	COG0363	glucosamine-6-phosphate deaminase activity
BSR08_RS14820	COG2188	Transcriptional regulator
BSR08_RS14825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BSR08_RS14840	COG1950	PFAM Membrane protein of
BSR08_RS14845	COG1983	PspC domain protein
BSR08_RS14850	COG3595	metallopeptidase activity
BSR08_RS14865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR08_RS14870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BSR08_RS14875	COG0556	nucleotide-excision repair
BSR08_RS14880	COG4897	Protein conserved in bacteria
BSR08_RS14885	COG3848	Pyruvate phosphate dikinase
BSR08_RS14885	COG0574	Belongs to the PEP-utilizing enzyme family
BSR08_RS14890	COG1309	transcriptional regulator
BSR08_RS14895	COG2814	Major facilitator Superfamily
BSR08_RS14900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSR08_RS14910	COG0793	Belongs to the peptidase S41A family
BSR08_RS14910	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS14915	COG2177	Part of the ABC transporter FtsEX involved in
BSR08_RS14920	COG2884	Cell division ATP-binding protein ftsE
BSR08_RS14925	COG2010	Cytochrome c
BSR08_RS14930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSR08_RS14940	COG0653	protein targeting
BSR08_RS14945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BSR08_RS14960	COG1516	flagellar protein fliS
BSR08_RS14965	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BSR08_RS14970	COG1334	flagellar protein FlaG
BSR08_RS14975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR08_RS14980	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BSR08_RS14985	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BSR08_RS14995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSR08_RS15000	COG4786	Flagellar basal body rod
BSR08_RS15000	COG1256	bacterial-type flagellum assembly
BSR08_RS15005	COG3418	PFAM FlgN family protein
BSR08_RS15010	COG2747	anti-sigma28 factor FlgM
BSR08_RS15020	COG1040	competence protein
BSR08_RS15030	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BSR08_RS15035	COG1307	EDD domain protein, DegV family
BSR08_RS15040	COG2197	response regulator
BSR08_RS15045	COG4585	Histidine kinase
BSR08_RS15050	COG1739	Uncharacterized protein family UPF0029
BSR08_RS15055	COG1316	TRANSCRIPTIONal
BSR08_RS15090	COG1131	(ABC) transporter
BSR08_RS15100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BSR08_RS15105	COG0438	transferase activity, transferring glycosyl groups
BSR08_RS15110	COG1215	transferase activity, transferring glycosyl groups
BSR08_RS15115	COG3206	protein involved in exopolysaccharide biosynthesis
BSR08_RS15120	COG3307	-O-antigen
BSR08_RS15130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BSR08_RS15135	COG0438	transferase activity, transferring glycosyl groups
BSR08_RS15135	COG0297	glycogen (starch) synthase activity
BSR08_RS15140	COG2244	polysaccharide biosynthetic process
BSR08_RS15155	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS15155	COG2247	cell wall binding repeat
BSR08_RS15160	COG2247	cell wall binding repeat
BSR08_RS15160	COG2385	sporulation resulting in formation of a cellular spore
BSR08_RS15190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BSR08_RS15195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSR08_RS15210	COG1134	teichoic acid transport
BSR08_RS15215	COG1682	transport, permease protein
BSR08_RS15230	COG0463	Glycosyl transferase, family 2
BSR08_RS15230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BSR08_RS15235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BSR08_RS15240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BSR08_RS15245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BSR08_RS15250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BSR08_RS15255	COG4193	domain, Protein
BSR08_RS15260	COG1482	cell wall glycoprotein biosynthetic process
BSR08_RS15265	COG0697	spore germination
BSR08_RS15270	COG0814	amino acid
BSR08_RS15285	COG1316	TRANSCRIPTIONal
BSR08_RS15290	COG0561	phosphatase activity
BSR08_RS15295	COG0791	NLP P60 protein
BSR08_RS15305	COG2843	Capsule synthesis protein
BSR08_RS15315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BSR08_RS15325	COG1609	Transcriptional regulator
BSR08_RS15330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSR08_RS15335	COG1869	D-ribose catabolic process
BSR08_RS15340	COG1129	ABC transporter
BSR08_RS15345	COG1172	Belongs to the binding-protein-dependent transport system permease family
BSR08_RS15350	COG1879	ABC-type sugar transport system periplasmic component
BSR08_RS15355	COG3103	Sh3 type 3 domain protein
BSR08_RS15365	COG2249	NAD(P)H dehydrogenase (quinone) activity
BSR08_RS15370	COG3527	Alpha-acetolactate decarboxylase
BSR08_RS15375	COG0028	Belongs to the TPP enzyme family
BSR08_RS15380	COG0583	DNA-binding transcription factor activity
BSR08_RS15385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BSR08_RS15400	COG5337	Spore coat protein CotH
BSR08_RS15410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BSR08_RS15420	COG0405	Gamma-glutamyltransferase
BSR08_RS15425	COG1522	sequence-specific DNA binding
BSR08_RS15430	COG2059	Chromate
BSR08_RS15435	COG2059	Chromate
BSR08_RS15445	COG0655	NAD(P)H dehydrogenase (quinone) activity
BSR08_RS15450	COG0583	DNA-binding transcription factor activity
BSR08_RS15480	COG5444	nuclease activity
BSR08_RS15500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BSR08_RS15505	COG4464	protein tyrosine phosphatase activity
BSR08_RS15510	COG0489	protein tyrosine kinase activity
BSR08_RS15515	COG3944	biosynthesis protein
BSR08_RS15525	COG4715	Zinc finger, swim domain protein
BSR08_RS15530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BSR08_RS15540	COG0561	phosphatase activity
BSR08_RS15545	COG1349	DNA-binding transcription factor activity
BSR08_RS15550	COG0629	single-stranded DNA binding
BSR08_RS15565	COG3764	Sortase (surface protein transpeptidase)
BSR08_RS15570	COG0745	RESPONSE REGULATOR receiver
BSR08_RS15570	COG2972	Histidine kinase
BSR08_RS15575	COG1970	mechanosensitive ion channel activity
BSR08_RS15580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BSR08_RS15585	COG0457	Tetratricopeptide repeat
BSR08_RS15590	COG4786	Flagellar basal body rod
BSR08_RS15595	COG4786	Flagellar basal body rod
BSR08_RS15600	COG1077	Cell shape determining protein MreB Mrl
BSR08_RS15605	COG1609	Transcriptional regulator
BSR08_RS15615	COG1846	Transcriptional regulator
BSR08_RS15620	COG2814	Major facilitator Superfamily
BSR08_RS15625	COG3420	alginic acid biosynthetic process
BSR08_RS15630	COG1953	Uracil, thiamine, allantoin
BSR08_RS15635	COG0477	Major facilitator Superfamily
BSR08_RS15640	COG1335	isochorismatase
BSR08_RS15650	COG0004	ammonium transporteR
BSR08_RS15655	COG0347	Belongs to the P(II) protein family
BSR08_RS15660	COG0671	phosphoesterase, PA-phosphatase related
BSR08_RS15670	COG0739	heme binding
BSR08_RS15675	COG1247	-acetyltransferase
BSR08_RS15685	COG2089	acid synthase
BSR08_RS15695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSR08_RS15700	COG0789	Transcriptional regulator
BSR08_RS15710	COG2910	NAD(P)H-binding
BSR08_RS15715	COG1959	2 iron, 2 sulfur cluster binding
BSR08_RS15720	COG0804	urea catabolic process
BSR08_RS15725	COG0832	Belongs to the urease beta subunit family
BSR08_RS15730	COG0831	urea catabolic process
BSR08_RS15745	COG3237	CsbD-like
BSR08_RS15750	COG1994	Peptidase M50
BSR08_RS15755	COG0457	Tetratricopeptide repeat
BSR08_RS15765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BSR08_RS15770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BSR08_RS15780	COG2304	oxidoreductase activity
BSR08_RS15790	COG2304	oxidoreductase activity
BSR08_RS15795	COG2385	sporulation resulting in formation of a cellular spore
BSR08_RS15800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BSR08_RS15810	COG4836	Membrane
BSR08_RS15820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BSR08_RS15825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BSR08_RS15830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BSR08_RS15835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BSR08_RS15840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BSR08_RS15845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BSR08_RS15855	COG0356	it plays a direct role in the translocation of protons across the membrane
BSR08_RS15865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BSR08_RS15870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BSR08_RS15875	COG4475	Protein of unknown function (DUF436)
BSR08_RS15880	COG0698	ribose 5-phosphate isomerase
BSR08_RS15885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BSR08_RS15890	COG1971	Probably functions as a manganese efflux pump
BSR08_RS15895	COG0009	L-threonylcarbamoyladenylate synthase
BSR08_RS15900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BSR08_RS15920	COG2890	protein-(glutamine-N5) methyltransferase activity
BSR08_RS15925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BSR08_RS15930	COG0346	lactoylglutathione lyase activity
BSR08_RS15935	COG0789	Transcriptional regulator
BSR08_RS15940	COG0679	Auxin Efflux Carrier
BSR08_RS15945	COG0281	malic enzyme
BSR08_RS15950	COG1435	thymidine kinase activity
BSR08_RS15960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BSR08_RS15965	COG1494	fructose-1,6-bisphosphatase
BSR08_RS15970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BSR08_RS15975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BSR08_RS15980	COG0191	fructose-bisphosphate aldolase activity
BSR08_RS15985	COG2204	response regulator
BSR08_RS15990	COG4821	SIS domain
BSR08_RS15995	COG0504	CTP synthase activity
BSR08_RS16000	COG3343	RNA polymerase activity
BSR08_RS16005	COG1960	acyl-CoA dehydrogenase activity
BSR08_RS16010	COG2181	nitrate reductase activity
BSR08_RS16010	COG0247	lactate metabolic process
BSR08_RS16015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSR08_RS16020	COG4294	response to UV
BSR08_RS16030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BSR08_RS16040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSR08_RS16050	COG2181	nitrate reductase activity
BSR08_RS16055	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BSR08_RS16060	COG1140	nitrate reductase beta subunit
BSR08_RS16065	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BSR08_RS16070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSR08_RS16080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BSR08_RS16085	COG2223	nitrite transmembrane transporter activity
BSR08_RS16090	COG0018	arginyl-trna synthetase
BSR08_RS16095	COG4506	Protein conserved in bacteria
BSR08_RS16110	COG0535	radical SAM domain protein
BSR08_RS16120	COG1131	(ABC) transporter
BSR08_RS16125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BSR08_RS16130	COG0612	Peptidase, M16
BSR08_RS16135	COG0612	Peptidase, M16
BSR08_RS16145	COG3391	amine dehydrogenase activity
BSR08_RS16150	COG3391	amine dehydrogenase activity
BSR08_RS16160	COG0457	Tetratricopeptide repeat
BSR08_RS16170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BSR08_RS16175	COG0010	Belongs to the arginase family
BSR08_RS16180	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BSR08_RS16185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSR08_RS16200	COG1994	Peptidase M50
BSR08_RS16205	COG1942	4-Oxalocrotonate Tautomerase
BSR08_RS16210	COG1846	Transcriptional regulator
BSR08_RS16215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BSR08_RS16220	COG0477	Major facilitator Superfamily
BSR08_RS16225	COG1959	2 iron, 2 sulfur cluster binding
BSR08_RS16230	COG3465	dGTPase activity
BSR08_RS16235	COG1078	dGTPase activity
BSR08_RS16240	COG4844	belongs to the
BSR08_RS16250	COG0697	spore germination
BSR08_RS16255	COG0095	Lipoate-protein ligase
BSR08_RS16260	COG0583	DNA-binding transcription factor activity
BSR08_RS16265	COG0280	phosphate acetyltransferase
BSR08_RS16270	COG3253	May function as heme-dependent peroxidase
BSR08_RS16275	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS16280	COG0436	Aminotransferase
BSR08_RS16285	COG2814	Major facilitator Superfamily
BSR08_RS16290	COG0151	Belongs to the GarS family
BSR08_RS16295	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS16300	COG1917	Cupin 2, conserved barrel domain protein
BSR08_RS16305	COG0077	Prephenate dehydratase
BSR08_RS16310	COG2814	Major facilitator Superfamily
BSR08_RS16315	COG0833	amino acid
BSR08_RS16320	COG4187	Peptidase family M20/M25/M40
BSR08_RS16325	COG1012	belongs to the aldehyde dehydrogenase family
BSR08_RS16330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BSR08_RS16340	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BSR08_RS16345	COG1091	dTDP-4-dehydrorhamnose reductase activity
BSR08_RS16350	COG1088	dTDP-glucose 4,6-dehydratase activity
BSR08_RS16355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BSR08_RS16360	COG3980	spore coat polysaccharide biosynthesis protein
BSR08_RS16365	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BSR08_RS16370	COG2089	acid synthase
BSR08_RS16375	COG0456	acetyltransferase
BSR08_RS16380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BSR08_RS16385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BSR08_RS16390	COG0463	Glycosyl transferase, family 2
BSR08_RS16405	COG2363	Small membrane protein
BSR08_RS16410	COG2233	PERMEase
BSR08_RS16420	COG1012	belongs to the aldehyde dehydrogenase family
BSR08_RS16425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BSR08_RS16430	COG1216	Glycosyl transferase, family 2
BSR08_RS16435	COG0351	phosphomethylpyrimidine kinase
BSR08_RS16445	COG1621	beta-fructofuranosidase activity
BSR08_RS16450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS16450	COG1263	PTS System
BSR08_RS16455	COG2116	formate transmembrane transporter activity
BSR08_RS16470	COG1404	Belongs to the peptidase S8 family
BSR08_RS16475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSR08_RS16480	COG0778	Nitroreductase
BSR08_RS16485	COG0772	Belongs to the SEDS family
BSR08_RS16500	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BSR08_RS16505	COG1845	cytochrome c oxidase, subunit III
BSR08_RS16510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BSR08_RS16515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BSR08_RS16520	COG2261	transglycosylase associated protein
BSR08_RS16525	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BSR08_RS16530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BSR08_RS16535	COG2246	polysaccharide biosynthetic process
BSR08_RS16540	COG1309	transcriptional regulator
BSR08_RS16550	COG3162	membrane
BSR08_RS16555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSR08_RS16560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BSR08_RS16565	COG2837	iron assimilation
BSR08_RS16570	COG2822	iron ion transport
BSR08_RS16575	COG0672	)-iron permease
BSR08_RS16580	COG0352	thiamine-phosphate diphosphorylase activity
BSR08_RS16585	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BSR08_RS16590	COG0583	DNA-binding transcription factor activity
BSR08_RS16595	COG1380	Effector of murein hydrolase LrgA
BSR08_RS16600	COG1346	cytolysis
BSR08_RS16605	COG2814	Major facilitator Superfamily
BSR08_RS16610	COG4895	conserved protein (DUF2196)
BSR08_RS16615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BSR08_RS16620	COG0346	lactoylglutathione lyase activity
BSR08_RS16635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BSR08_RS16640	COG1404	Belongs to the peptidase S8 family
BSR08_RS16645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS16645	COG1263	PTS System
BSR08_RS16650	COG3711	transcriptional antiterminator
BSR08_RS16655	COG1442	glycosyl transferase family 8
BSR08_RS16660	COG5522	Integral membrane protein (intg_mem_TP0381)
BSR08_RS16665	COG1846	Transcriptional regulator
BSR08_RS16670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BSR08_RS16675	COG2234	aminopeptidase activity
BSR08_RS16680	COG2357	RelA SpoT domain protein
BSR08_RS16690	COG2801	Transposase and inactivated derivatives
BSR08_RS16695	COG1575	Belongs to the MenA family. Type 1 subfamily
BSR08_RS16710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BSR08_RS16715	COG1696	Membrane protein involved in D-alanine export
BSR08_RS16720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BSR08_RS16725	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BSR08_RS16735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BSR08_RS16740	COG1486	melibiose metabolic process
BSR08_RS16745	COG1447	Phosphotransferase system cellobiose-specific component IIA
BSR08_RS16750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BSR08_RS16755	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BSR08_RS16760	COG3711	transcriptional antiterminator
BSR08_RS16760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR08_RS16770	COG2094	Belongs to the DNA glycosylase MPG family
BSR08_RS16775	COG0753	catalase activity
BSR08_RS16780	COG2814	Major facilitator Superfamily
BSR08_RS16785	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BSR08_RS16790	COG1131	(ABC) transporter
BSR08_RS16810	COG1595	DNA-templated transcription, initiation
BSR08_RS16815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BSR08_RS16820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BSR08_RS16825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BSR08_RS16830	COG4988	ABC transporter
BSR08_RS16835	COG1294	oxidase, subunit
BSR08_RS16840	COG1271	oxidase subunit
BSR08_RS16845	COG3493	citrate carrier protein
BSR08_RS16850	COG0501	Belongs to the peptidase M48B family
BSR08_RS16860	COG0726	polysaccharide deacetylase
BSR08_RS16865	COG3842	ATPase activity
BSR08_RS16870	COG2508	Transcriptional regulator
BSR08_RS16875	COG1012	belongs to the aldehyde dehydrogenase family
BSR08_RS16880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSR08_RS16890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BSR08_RS16900	COG4585	Histidine kinase
BSR08_RS16905	COG2197	response regulator
BSR08_RS16910	COG2195	Cleaves the N-terminal amino acid of tripeptides
BSR08_RS16920	COG4894	glucomannan catabolic process
BSR08_RS16925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BSR08_RS16930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BSR08_RS16935	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS16940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BSR08_RS16945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BSR08_RS16950	COG2610	gluconate transmembrane transporter activity
BSR08_RS16955	COG0500	methyltransferase
BSR08_RS16960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSR08_RS16975	COG0693	protein deglycase activity
BSR08_RS16975	COG0753	catalase activity
BSR08_RS16980	COG2851	Citrate transporter
BSR08_RS16985	COG2273	Hydrolase Family 16
BSR08_RS16990	COG3711	transcriptional antiterminator
BSR08_RS17000	COG2270	Major facilitator Superfamily
BSR08_RS17005	COG0513	Belongs to the DEAD box helicase family
BSR08_RS17010	COG2755	lipolytic protein G-D-S-L family
BSR08_RS17010	COG3401	FG-GAP repeat protein
BSR08_RS17140	COG0589	response to stress
BSR08_RS17150	COG1263	PTS System
BSR08_RS17150	COG2190	(PTS) system
BSR08_RS17150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS17160	COG5444	nuclease activity
BSR08_RS17170	COG5444	nuclease activity
BSR08_RS17190	COG0494	nUDIX hydrolase
BSR08_RS17195	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BSR08_RS17200	COG3507	Belongs to the glycosyl hydrolase 43 family
BSR08_RS17205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BSR08_RS17210	COG0833	amino acid
BSR08_RS17215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BSR08_RS17220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSR08_RS17225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BSR08_RS17230	COG2390	Transcriptional regulator
BSR08_RS17240	COG3192	ethanolamine utilization protein
BSR08_RS17245	COG2079	MmgE PrpD family protein
BSR08_RS17250	COG1473	amidohydrolase
BSR08_RS17255	COG1126	abc transporter atp-binding protein
BSR08_RS17260	COG0765	amino acid transport
BSR08_RS17265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR08_RS17270	COG0456	acetyltransferase
BSR08_RS17275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSR08_RS17280	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BSR08_RS17285	COG0561	phosphatase activity
BSR08_RS17315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSR08_RS17320	COG5294	Protein conserved in bacteria
BSR08_RS17335	COG2205	protein histidine kinase activity
BSR08_RS17340	COG0745	RESPONSE REGULATOR receiver
BSR08_RS17345	COG0191	fructose-bisphosphate aldolase activity
BSR08_RS17350	COG1082	Xylose isomerase domain protein TIM barrel
BSR08_RS17355	COG1082	Xylose isomerase domain protein TIM barrel
BSR08_RS17360	COG0673	inositol 2-dehydrogenase activity
BSR08_RS17365	COG2814	Major facilitator Superfamily
BSR08_RS17370	COG1082	Xylose isomerase domain protein TIM barrel
BSR08_RS17375	COG3962	Belongs to the TPP enzyme family
BSR08_RS17380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSR08_RS17400	COG1349	DNA-binding transcription factor activity
BSR08_RS17405	COG0667	Aldo Keto reductase
BSR08_RS17435	COG0326	Molecular chaperone. Has ATPase activity
BSR08_RS17495	COG1917	Cupin 2, conserved barrel domain protein
BSR08_RS17500	COG1309	transcriptional regulator
BSR08_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS17510	COG1846	Transcriptional regulator
BSR08_RS17515	COG1380	Effector of murein hydrolase LrgA
BSR08_RS17520	COG1346	cytolysis
BSR08_RS17525	COG5039	Polysaccharide pyruvyl transferase
BSR08_RS17530	COG1929	Belongs to the glycerate kinase type-1 family
BSR08_RS17535	COG1802	Transcriptional regulator
BSR08_RS17540	COG1070	Carbohydrate kinase
BSR08_RS17545	COG2610	gluconate transmembrane transporter activity
BSR08_RS17550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BSR08_RS17555	COG0450	alkyl hydroperoxide reductase
BSR08_RS17560	COG3634	alkyl hydroperoxide reductase activity
BSR08_RS17565	COG2723	6-phospho-beta-galactosidase activity
BSR08_RS17580	COG2188	Transcriptional regulator
BSR08_RS17590	COG1131	(ABC) transporter
BSR08_RS17595	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BSR08_RS17610	COG0071	Belongs to the small heat shock protein (HSP20) family
BSR08_RS17620	COG3773	Cell wall hydrolase
BSR08_RS17645	COG0210	DNA helicase
BSR08_RS17675	COG2963	transposase activity
BSR08_RS17710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BSR08_RS17725	COG1063	alcohol dehydrogenase
BSR08_RS17745	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
BSR08_RS17750	COG0456	acetyltransferase
BSR08_RS17755	COG0457	Tetratricopeptide repeat
BSR08_RS17765	COG0010	Belongs to the arginase family
BSR08_RS17770	COG0833	amino acid
BSR08_RS17775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BSR08_RS17795	COG5658	integral membrane protein
BSR08_RS17800	COG0640	Transcriptional regulator
BSR08_RS17805	COG3829	transcription factor binding
BSR08_RS17810	COG5002	protein histidine kinase activity
BSR08_RS17815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSR08_RS17820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BSR08_RS17825	COG4853	Protein conserved in bacteria
BSR08_RS17830	COG4863	YycH protein
BSR08_RS17835	COG5002	protein histidine kinase activity
BSR08_RS17840	COG0745	RESPONSE REGULATOR receiver
BSR08_RS17870	COG0346	lactoylglutathione lyase activity
BSR08_RS17875	COG0305	Participates in initiation and elongation during chromosome replication
BSR08_RS17890	COG3093	addiction module antidote protein HigA
BSR08_RS17895	COG2807	transmembrane transport
BSR08_RS17900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BSR08_RS17905	COG0359	binds to the 23S rRNA
BSR08_RS17910	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BSR08_RS17915	COG4241	membrane
BSR08_RS17930	COG1733	regulation of RNA biosynthetic process
BSR08_RS17935	COG1227	inorganic diphosphatase activity
BSR08_RS17950	COG2271	Major facilitator Superfamily
BSR08_RS17955	COG0789	Transcriptional regulator
BSR08_RS17955	COG4978	Transcriptional regulator
BSR08_RS17965	COG4319	ketosteroid isomerase
BSR08_RS17970	COG1357	PFAM Pentapeptide repeats (8 copies)
BSR08_RS17975	COG2814	Major facilitator Superfamily
BSR08_RS17985	COG1846	Transcriptional regulator
BSR08_RS17990	COG2153	protein acetylation
BSR08_RS17995	COG2364	Membrane
BSR08_RS18000	COG0456	acetyltransferase
BSR08_RS18005	COG2315	Protein conserved in bacteria
BSR08_RS18010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BSR08_RS18015	COG1331	Highly conserved protein containing a thioredoxin domain
BSR08_RS18020	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BSR08_RS18025	COG1331	Highly conserved protein containing a thioredoxin domain
BSR08_RS18030	COG1266	CAAX protease self-immunity
BSR08_RS18035	COG2814	Major facilitator Superfamily
BSR08_RS18035	COG0477	Major facilitator Superfamily
BSR08_RS18040	COG0346	lactoylglutathione lyase activity
BSR08_RS18045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSR08_RS18050	COG0542	response to heat
BSR08_RS18060	COG1609	Transcriptional regulator
BSR08_RS18065	COG0708	Exodeoxyribonuclease III
BSR08_RS18070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BSR08_RS18075	COG0629	single-stranded DNA binding
BSR08_RS18080	COG0360	Binds together with S18 to 16S ribosomal RNA
BSR08_RS18085	COG0012	GTP binding
BSR08_RS18090	COG0243	molybdopterin cofactor binding
BSR08_RS18095	COG4481	Protein conserved in bacteria
BSR08_RS18100	COG3949	Membrane
BSR08_RS18110	COG1475	DNA binding
BSR08_RS18115	COG1192	Involved in chromosome partitioning
BSR08_RS18125	COG1475	DNA binding
BSR08_RS18130	COG0357	Ribosomal RNA small subunit methyltransferase G
BSR08_RS18135	COG0445	tRNA wobble uridine modification
BSR08_RS18140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BSR08_RS18145	COG1847	R3H domain protein
BSR08_RS18150	COG0706	membrane insertase activity
BSR08_RS18155	COG0594	ribonuclease P activity
BSR08_RS18165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BSR08_RS18170	COG0592	DNA-directed DNA polymerase activity
BSR08_RS18175	COG2501	S4 domain
BSR08_RS18180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BSR08_RS18190	COG0187	DNA topoisomerase II activity
BSR08_RS18195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BSR08_RS18230	COG0516	GMP reductase activity
BSR08_RS18230	COG0517	IMP dehydrogenase activity
BSR08_RS18235	COG1686	Belongs to the peptidase S11 family
BSR08_RS18240	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BSR08_RS18245	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BSR08_RS18250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BSR08_RS18260	COG1428	Deoxynucleoside kinase
BSR08_RS18265	COG1428	Deoxynucleoside kinase
BSR08_RS18270	COG3858	chitin binding
BSR08_RS18270	COG1388	LysM domain
BSR08_RS18275	COG1335	isochorismatase
BSR08_RS18280	COG0590	tRNA wobble adenosine to inosine editing
BSR08_RS18290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BSR08_RS18295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BSR08_RS18300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BSR08_RS18345	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BSR08_RS18350	COG3853	Toxic anion resistance protein (TelA)
BSR08_RS18355	COG1982	Orn Lys Arg decarboxylase major
BSR08_RS18360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BSR08_RS18365	COG3870	Protein conserved in bacteria
BSR08_RS18370	COG1728	Protein conserved in bacteria
BSR08_RS18375	COG0470	DNA polymerase III
BSR08_RS18380	COG1774	PSP1 C-terminal conserved region
BSR08_RS18385	COG4467	Involved in initiation control of chromosome replication
BSR08_RS18390	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BSR08_RS18395	COG2827	Endonuclease containing a URI domain
BSR08_RS18400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BSR08_RS18405	COG2002	toxin-antitoxin pair type II binding
BSR08_RS18410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSR08_RS18410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSR08_RS18415	COG0084	hydrolase, TatD family'
BSR08_RS18420	COG3584	3D domain protein
BSR08_RS18420	COG3583	domain protein
BSR08_RS18425	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BSR08_RS18430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BSR08_RS18440	COG4466	Protein conserved in bacteria
BSR08_RS18450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BSR08_RS18455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSR08_RS18460	COG0251	oxidation-reduction process
BSR08_RS18465	COG2088	sporulation resulting in formation of a cellular spore
BSR08_RS18470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BSR08_RS18475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BSR08_RS18480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BSR08_RS18485	COG0193	aminoacyl-tRNA hydrolase activity
BSR08_RS18495	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BSR08_RS18500	COG2002	toxin-antitoxin pair type II binding
BSR08_RS18505	COG2244	polysaccharide biosynthetic process
BSR08_RS18510	COG3956	TIGRFAM MazG family protein
BSR08_RS18515	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BSR08_RS18530	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BSR08_RS18535	COG1098	S1 RNA binding domain
BSR08_RS18550	COG2208	phosphoserine phosphatase activity
BSR08_RS18555	COG2304	oxidoreductase activity
BSR08_RS18560	COG0515	serine threonine protein kinase
BSR08_RS18565	COG0037	tRNA processing
BSR08_RS18570	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BSR08_RS18575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BSR08_RS18580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BSR08_RS18585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BSR08_RS18590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSR08_RS18595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSR08_RS18600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BSR08_RS18605	COG0512	Glutamine amidotransferase of anthranilate synthase
BSR08_RS18610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BSR08_RS18615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BSR08_RS18620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BSR08_RS18625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BSR08_RS18630	COG1396	sequence-specific DNA binding
BSR08_RS18635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BSR08_RS18640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BSR08_RS18720	COG4463	regulation of RNA biosynthetic process
BSR08_RS18725	COG3880	PFAM UvrB UvrC protein
BSR08_RS18730	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BSR08_RS18735	COG0542	response to heat
BSR08_RS18740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BSR08_RS18745	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BSR08_RS18750	COG4956	integral membrane protein (PIN domain superfamily)
BSR08_RS18755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BSR08_RS18760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BSR08_RS18765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSR08_RS18775	COG1045	serine acetyltransferase
BSR08_RS18780	COG0215	cysteine-tRNA ligase activity
BSR08_RS18785	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BSR08_RS18790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSR08_RS18795	COG3688	RNA-binding protein containing a PIN domain
BSR08_RS18800	COG1595	DNA-templated transcription, initiation
BSR08_RS18810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BSR08_RS18815	COG0250	Participates in transcription elongation, termination and antitermination
BSR08_RS18825	COG0081	regulation of translation
BSR08_RS18830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BSR08_RS18840	COG2813	Specifically methylates the guanine in position
BSR08_RS18845	COG0085	RNA polymerase activity
BSR08_RS18850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BSR08_RS18855	COG1358	cellular component organization or biogenesis
BSR08_RS18860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BSR08_RS18865	COG0049	tRNA binding
BSR08_RS18870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BSR08_RS18875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BSR08_RS18880	COG0596	Alpha beta hydrolase
BSR08_RS18890	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BSR08_RS18895	COG0088	Forms part of the polypeptide exit tunnel
BSR08_RS18905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BSR08_RS18920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BSR08_RS18925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BSR08_RS18935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BSR08_RS18940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BSR08_RS18950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BSR08_RS18960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BSR08_RS18965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BSR08_RS18970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BSR08_RS18975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BSR08_RS18985	COG0200	Binds to the 23S rRNA
BSR08_RS18990	COG0201	protein transport
BSR08_RS18995	COG0563	adenylate kinase activity
BSR08_RS19000	COG0024	Methionine aminopeptidase
BSR08_RS19005	COG2163	COG2163 Ribosomal protein L14E L6E L27E
BSR08_RS19015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BSR08_RS19020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BSR08_RS19025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BSR08_RS19030	COG0202	RNA polymerase activity
BSR08_RS19035	COG0203	ribosomal protein L17
BSR08_RS19040	COG1122	ATPase activity
BSR08_RS19045	COG1122	ATPase activity
BSR08_RS19050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BSR08_RS19055	COG0101	tRNA pseudouridine synthase activity
BSR08_RS19060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BSR08_RS19065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BSR08_RS19075	COG2226	methyltransferase
BSR08_RS19085	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS19090	COG0489	protein tyrosine kinase activity
BSR08_RS19100	COG2194	sulfuric ester hydrolase activity
BSR08_RS19105	COG0726	polysaccharide deacetylase
BSR08_RS19185	COG0659	secondary active sulfate transmembrane transporter activity
BSR08_RS19190	COG0385	Bile acid
BSR08_RS19195	COG2819	hydrolase of the alpha beta superfamily
BSR08_RS19200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR08_RS19205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR08_RS19210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSR08_RS19215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSR08_RS19215	COG2207	Transcriptional regulator
BSR08_RS19220	COG3876	Protein conserved in bacteria
BSR08_RS19225	COG1472	Belongs to the glycosyl hydrolase 3 family
BSR08_RS19230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BSR08_RS19235	COG1263	PTS System
BSR08_RS19235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS19240	COG1737	Transcriptional regulator
BSR08_RS19245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BSR08_RS19250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR08_RS19255	COG1683	Conserved Protein
BSR08_RS19285	COG1595	DNA-templated transcription, initiation
BSR08_RS19290	COG5662	AntiSigma factor
BSR08_RS19295	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BSR08_RS19300	COG4856	YbbR-like protein
BSR08_RS19305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSR08_RS19315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BSR08_RS19325	COG2169	Transcriptional regulator
BSR08_RS19330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BSR08_RS19335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BSR08_RS19340	COG3002	Belongs to the UPF0753 family
BSR08_RS19345	COG0288	reversible hydration of carbon dioxide
BSR08_RS19355	COG5609	conserved protein (DUF2294)
BSR08_RS19365	COG0642	Histidine kinase
BSR08_RS19375	COG0515	serine threonine protein kinase
BSR08_RS19390	COG1113	amino acid transport
BSR08_RS19405	COG2602	Beta-lactamase
BSR08_RS19410	COG2124	cytochrome p450
BSR08_RS19420	COG0531	amino acid
BSR08_RS19425	COG0584	glycerophosphoryl diester phosphodiesterase
BSR08_RS19430	COG2271	Major facilitator Superfamily
BSR08_RS19445	COG0456	acetyltransferase
BSR08_RS19445	COG1846	Transcriptional regulator
BSR08_RS19465	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS19470	COG0697	spore germination
BSR08_RS19475	COG2207	Transcriptional regulator
BSR08_RS19475	COG1917	Cupin 2, conserved barrel domain protein
BSR08_RS19490	COG5632	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS19490	COG1388	LysM domain
BSR08_RS19490	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS19495	COG1388	LysM domain
BSR08_RS19495	COG5632	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS19495	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS19500	COG3409	Peptidoglycan-binding domain 1 protein
BSR08_RS19500	COG1388	LysM domain
BSR08_RS19500	COG5632	N-Acetylmuramoyl-L-alanine amidase
BSR08_RS19515	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BSR08_RS19520	COG3591	Belongs to the peptidase S1B family
BSR08_RS19530	COG0596	Alpha beta hydrolase
BSR08_RS19535	COG1183	phosphatidylcholine synthase activity
BSR08_RS19540	COG0586	Pfam SNARE associated Golgi protein
BSR08_RS19545	COG0688	phosphatidylethanolamine metabolic process
BSR08_RS19555	COG2312	Erythromycin esterase
BSR08_RS19560	COG2207	Transcriptional regulator
BSR08_RS19565	COG1054	Belongs to the UPF0176 family
BSR08_RS19570	COG1301	dicarboxylic acid transport
BSR08_RS19575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSR08_RS19575	COG1263	PTS System
BSR08_RS19575	COG2190	(PTS) system
BSR08_RS19580	COG0363	glucosamine-6-phosphate deaminase activity
BSR08_RS19585	COG2188	Transcriptional regulator
BSR08_RS19595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BSR08_RS19600	COG0833	amino acid
BSR08_RS19605	COG2040	homocysteine
BSR08_RS19620	COG2066	Belongs to the glutaminase family
BSR08_RS19625	COG4191	Histidine kinase
BSR08_RS19630	COG0784	Response regulator, receiver
BSR08_RS19640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BSR08_RS19645	COG1012	belongs to the aldehyde dehydrogenase family
BSR08_RS19650	COG2271	Major facilitator Superfamily
BSR08_RS19655	COG4948	Mandelate Racemase Muconate Lactonizing
BSR08_RS19660	COG2186	Transcriptional regulator
BSR08_RS19665	COG2721	sulfolactate sulfo-lyase activity
BSR08_RS19670	COG3173	Aminoglycoside phosphotransferase
BSR08_RS19680	COG0697	spore germination
BSR08_RS19685	COG0745	RESPONSE REGULATOR receiver
BSR08_RS19690	COG2205	protein histidine kinase activity
BSR08_RS19695	COG1131	(ABC) transporter
BSR08_RS19710	COG3773	Cell wall hydrolase
BSR08_RS19715	COG2304	oxidoreductase activity
BSR08_RS19725	COG3540	Alkaline phosphatase
BSR08_RS19730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSR08_RS19735	COG0805	protein transport
BSR08_RS19740	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BSR08_RS19745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BSR08_RS19750	COG0477	Major facilitator Superfamily
BSR08_RS19755	COG1309	transcriptional regulator
BSR08_RS19760	COG0252	asparaginase activity
BSR08_RS19765	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BSR08_RS19770	COG1714	RDD family
BSR08_RS19775	COG3012	SEC-C Motif Domain Protein
BSR08_RS19775	COG1405	negative regulation of cell septum assembly
BSR08_RS19785	COG3279	Response regulator of the LytR AlgR family
BSR08_RS19795	COG1668	transmembrane transport
BSR08_RS19800	COG0667	Aldo Keto reductase
BSR08_RS19810	COG1595	DNA-templated transcription, initiation
BSR08_RS19815	COG1595	DNA-templated transcription, initiation
BSR08_RS19820	COG1876	peptidase activity
BSR08_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS19835	COG0366	Alpha amylase catalytic
BSR08_RS19840	COG0803	Belongs to the bacterial solute-binding protein 9 family
BSR08_RS19845	COG1121	(ABC) transporter
BSR08_RS19850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BSR08_RS19860	COG2310	stress, protein
BSR08_RS19865	COG2310	stress, protein
BSR08_RS19870	COG2310	stress, protein
BSR08_RS19875	COG0861	Integral membrane protein TerC family
BSR08_RS19885	COG3853	Toxic anion resistance protein (TelA)
BSR08_RS19895	COG2801	Transposase and inactivated derivatives
BSR08_RS19900	COG0477	Major facilitator Superfamily
BSR08_RS19905	COG2814	Major facilitator Superfamily
BSR08_RS19910	COG0640	Transcriptional regulator
BSR08_RS19915	COG4175	Glycine betaine
BSR08_RS19915	COG0517	IMP dehydrogenase activity
BSR08_RS19920	COG4176	ABC-type proline glycine betaine transport system permease component
BSR08_RS19925	COG2113	Glycine betaine
BSR08_RS19930	COG1473	amidohydrolase
BSR08_RS19935	COG1288	antiporter activity
BSR08_RS19950	COG0039	L-malate dehydrogenase activity
BSR08_RS19965	COG3403	YqcI/YcgG family
BSR08_RS19980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BSR08_RS19985	COG1660	Displays ATPase and GTPase activities
BSR08_RS19995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BSR08_RS20010	COG2226	methyltransferase
BSR08_RS20015	COG0583	DNA-binding transcription factor activity
BSR08_RS20020	COG3458	cephalosporin-C deacetylase activity
BSR08_RS20025	COG3541	Predicted nucleotidyltransferase
BSR08_RS20030	COG0506	proline dehydrogenase activity
BSR08_RS20035	COG1012	belongs to the aldehyde dehydrogenase family
BSR08_RS20040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSR08_RS20045	COG2508	Transcriptional regulator
BSR08_RS20050	COG3689	TIGRFAM TIGR03943 family protein
BSR08_RS20055	COG0701	Predicted permease
BSR08_RS20060	COG2267	carboxylic ester hydrolase activity
BSR08_RS20065	COG0492	ferredoxin-NADP+ reductase activity
BSR08_RS20070	COG1587	Uroporphyrinogen-III synthase
BSR08_RS20070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BSR08_RS20075	COG2146	nitrite reductase [NAD(P)H] activity
BSR08_RS20080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BSR08_RS20085	COG0243	molybdopterin cofactor binding
BSR08_RS20090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BSR08_RS20095	COG2223	nitrite transmembrane transporter activity
BSR08_RS20100	COG1469	GTP cyclohydrolase I activity
BSR08_RS20105	COG1376	ErfK ybiS ycfS ynhG family protein
BSR08_RS20120	COG0765	amino acid transport
BSR08_RS20125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR08_RS20135	COG1714	RDD family
BSR08_RS20145	COG1846	Transcriptional regulator
BSR08_RS20160	COG2723	6-phospho-beta-galactosidase activity
BSR08_RS20170	COG3209	COG3209 Rhs family protein
BSR08_RS20180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BSR08_RS20185	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BSR08_RS20190	COG1733	regulation of RNA biosynthetic process
BSR08_RS20195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BSR08_RS20200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BSR08_RS20205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BSR08_RS20210	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BSR08_RS20215	COG2814	Major facilitator Superfamily
BSR08_RS20225	COG0697	spore germination
BSR08_RS20230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR08_RS20240	COG2364	Membrane
BSR08_RS20250	COG1126	abc transporter atp-binding protein
BSR08_RS20255	COG0765	amino acid transport
BSR08_RS20260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSR08_RS20265	COG0583	DNA-binding transcription factor activity
BSR08_RS20270	COG0163	prenyltransferase activity
BSR08_RS20275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BSR08_RS20290	COG0596	Alpha beta hydrolase
BSR08_RS20295	COG3104	oligopeptide transport
BSR08_RS20300	COG5434	Belongs to the glycosyl hydrolase 28 family
BSR08_RS20310	COG0697	spore germination
BSR08_RS20320	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BSR08_RS20325	COG1136	(ABC) transporter
BSR08_RS20330	COG0577	efflux transmembrane transporter activity
BSR08_RS20335	COG0745	RESPONSE REGULATOR receiver
BSR08_RS20340	COG3850	Histidine kinase
BSR08_RS20340	COG5002	protein histidine kinase activity
BSR08_RS20345	COG0457	Tetratricopeptide repeat
BSR08_RS20365	COG0527	aspartate kinase activity
BSR08_RS20370	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSR08_RS20375	COG4605	iron ion homeostasis
BSR08_RS20380	COG4604	ABC transporter, ATP-binding protein
BSR08_RS20385	COG4607	ABC-type enterochelin transport system periplasmic component
BSR08_RS20395	COG2814	Major facilitator Superfamily
BSR08_RS20400	COG1309	transcriptional regulator
BSR08_RS20405	COG0778	Nitroreductase
BSR08_RS20410	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BSR08_RS20415	COG0640	Transcriptional regulator
BSR08_RS20420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR08_RS20425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BSR08_RS20430	COG1012	belongs to the aldehyde dehydrogenase family
BSR08_RS20435	COG4975	Glucose uptake
BSR08_RS20440	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS20445	COG4549	nuclear export factor GLE1
BSR08_RS20450	COG2372	response to copper ion
BSR08_RS20450	COG1276	copper resistance
BSR08_RS20455	COG1349	DNA-binding transcription factor activity
BSR08_RS20465	COG2213	PTS system mannitol-specific
BSR08_RS20470	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR08_RS20475	COG0246	Mannitol dehydrogenase
BSR08_RS20480	COG0473	3-isopropylmalate dehydrogenase activity
BSR08_RS20485	COG0681	Belongs to the peptidase S26 family
BSR08_RS20495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BSR08_RS20505	COG0561	phosphatase activity
BSR08_RS20510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BSR08_RS20515	COG1914	H( )-stimulated, divalent metal cation uptake system
BSR08_RS20520	COG4336	lyase activity
BSR08_RS20525	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BSR08_RS20530	COG1984	allophanate hydrolase subunit 2
BSR08_RS20535	COG1414	Transcriptional regulator
BSR08_RS20540	COG2755	lipolytic protein G-D-S-L family
BSR08_RS20550	COG2329	Antibiotic biosynthesis monooxygenase
BSR08_RS20555	COG0768	penicillin binding
BSR08_RS20560	COG4989	oxidoreductase activity
BSR08_RS20565	COG3711	transcriptional antiterminator
BSR08_RS20570	COG0318	PFAM AMP-dependent synthetase and ligase
BSR08_RS20575	COG2226	methyltransferase
BSR08_RS20580	COG1028	Short-chain dehydrogenase reductase Sdr
BSR08_RS20585	COG1917	Cupin 2, conserved barrel domain protein
BSR08_RS20590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR08_RS20595	COG3871	stress protein (general stress protein 26)
BSR08_RS20605	COG2814	Major facilitator Superfamily
BSR08_RS20610	COG1522	sequence-specific DNA binding
BSR08_RS20615	COG0551	DNA topoisomerase type I activity
BSR08_RS20615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BSR08_RS20620	COG0494	nUDIX hydrolase
BSR08_RS20625	COG0028	Belongs to the TPP enzyme family
BSR08_RS20655	COG1914	H( )-stimulated, divalent metal cation uptake system
BSR08_RS20660	COG2261	transglycosylase associated protein
BSR08_RS20665	COG4876	unkown
BSR08_RS20670	COG2217	Heavy metal translocating P-type atpase
BSR08_RS20675	COG3729	General stress protein
BSR08_RS20680	COG0662	Cupin 2, conserved barrel domain protein
BSR08_RS20685	COG2329	Antibiotic biosynthesis monooxygenase
BSR08_RS20690	COG3546	catalase activity
BSR08_RS20695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BSR08_RS20700	COG3290	protein histidine kinase activity
BSR08_RS20705	COG4565	transcriptional regulatory protein
BSR08_RS20710	COG1301	dicarboxylic acid transport
BSR08_RS20715	COG0628	permease
BSR08_RS20720	COG1131	(ABC) transporter
BSR08_RS20725	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BSR08_RS20735	COG1960	acyl-CoA dehydrogenase activity
BSR08_RS20750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BSR08_RS20755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR08_RS20760	COG1181	Belongs to the D-alanine--D-alanine ligase family
BSR08_RS20765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BSR08_RS20775	COG0513	Belongs to the DEAD box helicase family
BSR08_RS20780	COG3402	PFAM membrane-flanked domain
BSR08_RS20785	COG3428	Bacterial PH domain
BSR08_RS20790	COG0705	Rhomboid family
BSR08_RS20795	COG0736	holo-[acyl-carrier-protein] synthase activity
BSR08_RS20800	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BSR08_RS20805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BSR08_RS20810	COG0864	Transcriptional regulator
BSR08_RS20815	COG2337	Toxic component of a toxin-antitoxin (TA) module
BSR08_RS20820	COG1366	Belongs to the anti-sigma-factor antagonist family
BSR08_RS20825	COG1366	Belongs to the anti-sigma-factor antagonist family
BSR08_RS20830	COG2172	sigma factor antagonist activity
BSR08_RS20835	COG2208	phosphoserine phosphatase activity
BSR08_RS20840	COG1366	Belongs to the anti-sigma-factor antagonist family
BSR08_RS20845	COG2172	sigma factor antagonist activity
BSR08_RS20850	COG1191	sigma factor activity
BSR08_RS20855	COG2208	phosphoserine phosphatase activity
BSR08_RS20870	COG1673	EVE domain
BSR08_RS20875	COG1846	Transcriptional regulator
BSR08_RS20880	COG2183	response to ionizing radiation
BSR08_RS20885	COG3091	SprT-like family
BSR08_RS20925	COG0582	viral genome integration into host DNA
BSR08_RS20930	COG2856	Zn peptidase
BSR08_RS20935	COG1396	sequence-specific DNA binding
BSR08_RS20960	COG1674	ftsk spoiiie
BSR08_RS20965	COG2946	Replication initiation factor
BSR08_RS21005	COG0433	COG0433 Predicted ATPase
BSR08_RS21015	COG5644	endopeptidase inhibitor activity
BSR08_RS21025	COG0791	NLP P60 protein
BSR08_RS21025	COG0741	lytic transglycosylase activity
BSR08_RS21040	COG0457	Tetratricopeptide repeat
BSR08_RS21075	COG0583	DNA-binding transcription factor activity
BSR08_RS21080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR08_RS21090	COG5444	nuclease activity
BSR08_RS21095	COG1476	TRANSCRIPTIONal
BSR08_RS21120	COG0693	protein deglycase activity
BSR08_RS21125	COG1278	Cold shock
BSR08_RS21130	COG1329	Transcriptional regulator
BSR08_RS21140	COG0697	spore germination
BSR08_RS21145	COG1917	Cupin 2, conserved barrel domain protein
BSR08_RS21145	COG2207	Transcriptional regulator
BSR08_RS21155	COG2207	Transcriptional regulator
BSR08_RS21155	COG3708	Transcriptional regulator
BSR08_RS21160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR08_RS21175	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BSR08_RS21190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSR08_RS21195	COG1309	transcriptional regulator
BSR08_RS21200	COG0697	spore germination
BSR08_RS21205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR08_RS21210	COG2030	dehydratase
BSR08_RS21215	COG3545	Serine hydrolase
BSR08_RS21225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSR08_RS21230	COG0640	Transcriptional regulator
BSR08_RS21235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BSR08_RS21245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSR08_RS21250	COG0697	spore germination
BSR08_RS21255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSR08_RS21260	COG0076	glutamate decarboxylase activity
BSR08_RS21265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BSR08_RS21270	COG0640	Transcriptional regulator
BSR08_RS21275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BSR08_RS21290	COG4585	Histidine kinase
BSR08_RS21295	COG2197	response regulator
BSR08_RS21300	COG2409	Drug exporters of the RND superfamily
BSR08_RS21305	COG0596	Alpha beta hydrolase
BSR08_RS21310	COG1811	Na channel or pump
BSR08_RS21315	COG0789	Transcriptional regulator
BSR08_RS21315	COG4978	Transcriptional regulator
BSR08_RS21320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BSR08_RS21325	COG0778	Nitroreductase
BSR08_RS21330	COG0346	lactoylglutathione lyase activity
BSR08_RS21335	COG2259	Doxx family
BSR08_RS21340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSR08_RS21370	COG2323	membrane
BSR08_RS21375	COG0071	Belongs to the small heat shock protein (HSP20) family
BSR08_RS21390	COG1309	transcriptional regulator
BSR08_RS21400	COG0456	acetyltransferase
BSR08_RS21405	COG0488	(ABC) transporter
BSR08_RS21410	COG1113	amino acid transport
BSR08_RS21415	COG2318	DinB family
BSR08_RS21420	COG1846	Transcriptional regulator
BSR08_RS21425	COG2409	Drug exporters of the RND superfamily
BSR08_RS21425	COG1033	growth of symbiont in host cell
BSR08_RS21430	COG0778	Nitroreductase
BSR08_RS21435	COG1846	Transcriptional regulator
BSR08_RS21440	COG2814	Major facilitator Superfamily
BSR08_RS21445	COG0730	response to heat
BSR08_RS21450	COG1802	Transcriptional regulator
BSR08_RS21455	COG3858	chitin binding
BSR08_RS21455	COG1388	LysM domain
BSR08_RS21460	COG1819	glycosyl
BSR08_RS21470	COG1785	Belongs to the alkaline phosphatase family
BSR08_RS21475	COG5646	InterPro IPR014922
BSR08_RS21485	COG0454	-acetyltransferase
BSR08_RS21490	COG1078	dGTPase activity
BSR08_RS21495	COG1388	LysM domain
BSR08_RS21500	COG2814	Major facilitator Superfamily
BSR08_RS21505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BSR08_RS21520	COG2723	6-phospho-beta-galactosidase activity
BSR08_RS21525	COG2188	Transcriptional regulator
BSR08_RS21530	COG1940	carbohydrate kinase activity
BSR08_RS21540	COG4124	Belongs to the glycosyl hydrolase 26 family
BSR08_RS21585	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BSR08_RS21590	COG0802	atpase or kinase
BSR08_RS21595	COG1214	PFAM Peptidase M22, glycoprotease
BSR08_RS21600	COG0456	acetyltransferase
BSR08_RS21605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BSR08_RS21610	COG0488	(ABC) transporter
BSR08_RS21615	COG0315	cyclic pyranopterin monophosphate synthase activity
BSR08_RS21620	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BSR08_RS21625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSR08_RS21630	COG0805	protein transport
BSR08_RS21645	COG1266	CAAX protease self-immunity
BSR08_RS21655	COG0459	protein refolding
BSR08_RS21670	COG0457	Tetratricopeptide repeat
BSR08_RS21675	COG1063	alcohol dehydrogenase
BSR08_RS21680	COG2211	Major facilitator Superfamily
BSR08_RS21685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSR08_RS21695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BSR08_RS21700	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BSR08_RS21705	COG4260	virion core protein, lumpy skin disease virus
BSR08_RS21715	COG2814	Major facilitator Superfamily
BSR08_RS21720	COG1063	alcohol dehydrogenase
BSR08_RS21725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BSR08_RS21730	COG0823	Involved in the tonB-independent uptake of proteins
BSR08_RS21735	COG2801	Transposase and inactivated derivatives
BSR08_RS21755	COG2267	carboxylic ester hydrolase activity
BSR08_RS21765	COG2132	Multicopper oxidase
BSR08_RS21770	COG1113	amino acid transport
BSR08_RS21780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BSR08_RS21785	COG0714	Associated with various cellular activities
BSR08_RS21790	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BSR08_RS21795	COG1305	Transglutaminase-like
BSR08_RS21800	COG0519	Catalyzes the synthesis of GMP from XMP
BSR08_RS21800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BSR08_RS21810	COG2252	PERMEase
BSR08_RS21815	COG3064	Membrane
BSR08_RS21825	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BSR08_RS21835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BSR08_RS21840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BSR08_RS21845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BSR08_RS21850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BSR08_RS21855	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BSR08_RS21860	COG0047	phosphoribosylformylglycinamidine synthase activity
BSR08_RS21865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BSR08_RS21870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BSR08_RS21875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BSR08_RS21880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BSR08_RS21885	COG0138	bifunctional purine biosynthesis protein purh
BSR08_RS21890	COG0151	Belongs to the GarS family
BSR08_RS21895	COG1522	sequence-specific DNA binding
BSR08_RS21900	COG0531	amino acid
BSR08_RS21910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BSR08_RS21915	COG1470	cell adhesion involved in biofilm formation
BSR08_RS21920	COG4496	protein, YerC YecD
BSR08_RS21925	COG0069	glutamate synthase activity
BSR08_RS21930	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BSR08_RS21935	COG0210	DNA helicase
BSR08_RS21940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BSR08_RS21945	COG4851	CamS sex pheromone cAM373 precursor
BSR08_RS21955	COG2801	Transposase and inactivated derivatives
BSR08_RS21960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSR08_RS21965	COG1285	pathogenesis
BSR08_RS21970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSR08_RS21975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BSR08_RS21980	COG0154	amidase activity
BSR08_RS21985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BSR08_RS21990	COG1309	transcriptional regulator
BSR08_RS21995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSR08_RS22000	COG1597	lipid kinase activity
BSR08_RS22005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSR08_RS22010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BSR08_RS22035	COG5444	nuclease activity
BSR08_RS22045	COG0457	Tetratricopeptide repeat
BSR08_RS22055	COG0217	transcriptional regulatory protein
BSR08_RS22065	COG1309	transcriptional regulator
BSR08_RS22080	COG3546	catalase activity
BSR08_RS22085	COG0454	-acetyltransferase
BSR08_RS22095	COG5578	integral membrane protein
BSR08_RS22100	COG2972	Histidine kinase
BSR08_RS22110	COG1653	transport
BSR08_RS22115	COG1175	transmembrane transport
BSR08_RS22130	COG2207	Transcriptional regulator
BSR08_RS22175	COG3546	catalase activity
BSR08_RS22200	COG2972	Histidine kinase
BSR08_RS22240	COG0395	ABC-type sugar transport system, permease component
BSR08_RS22250	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BSR08_RS22545	COG0488	(ABC) transporter
BSR08_RS22555	COG0513	Belongs to the DEAD box helicase family
BSR08_RS22585	COG0471	metal ion transport
BSR08_RS22610	COG3290	protein histidine kinase activity
BSR08_RS22620	COG3181	Tripartite tricarboxylate transporter family receptor