locus-tag class description HT135_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HT135_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HT135_RS00015 ENOG410848D S4 domain protein YaaA HT135_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HT135_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HT135_RS00075 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HT135_RS00085 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HT135_RS00090 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HT135_RS00095 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HT135_RS00105 ENOG4105ZMH deoxynucleoside kinase HT135_RS00115 ENOG4105VRS hydrolase family 18 HT135_RS00120 ENOG4105GTG Isochorismatase HT135_RS00125 ENOG4108Z6B deaminase HT135_RS00135 ENOG4105C6E dna polymerase iii HT135_RS00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HT135_RS00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HT135_RS00155 ENOG41067KS pro-sigma K processing HT135_RS00195 ENOG4105CDW Resistance protein HT135_RS00200 ENOG4105CXN decarboxylase HT135_RS00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HT135_RS00210 ENOG4105X0R protein from nitrogen regulatory protein P-II HT135_RS00215 ENOG4105XVJ Protein of unknown function (DUF327) HT135_RS00220 ENOG4105FA2 dna polymerase iii HT135_RS00225 ENOG4105MA4 psp1 domain protein HT135_RS00235 ENOG41060K3 Methyltransferase HT135_RS00240 ENOG4105VC4 domain protein HT135_RS00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HT135_RS00250 ENOG4105KRN Transcriptional regulator, abrb family HT135_RS00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HT135_RS00260 ENOG4105F8V Hydrolase, tatD family HT135_RS00265 ENOG41069ER domain protein HT135_RS00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HT135_RS00280 ENOG4105XFA sporulation peptidase YabG HT135_RS00285 ENOG4105W42 Veg protein HT135_RS00290 ENOG4105XEW small acid-soluble spore protein HT135_RS00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HT135_RS00300 ENOG4105DFT pur operon repressor HT135_RS00305 ENOG4105KME endoribonuclease L-psp HT135_RS00310 ENOG4105K4W Could be involved in septation (By similarity) HT135_RS00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HT135_RS00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HT135_RS00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HT135_RS00330 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HT135_RS00340 ENOG4108JA2 transcriptioN-repair coupling factor HT135_RS00345 ENOG4108M14 stage v sporulation protein t HT135_RS00355 ENOG4108IY2 MazG family HT135_RS00360 ENOG41082I2 s4 domain protein HT135_RS00365 ENOG4105VYY sporulation protein yabp HT135_RS00380 ENOG41060GV RNA binding s1 domain protein HT135_RS00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HT135_RS00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase HT135_RS00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HT135_RS00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HT135_RS00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HT135_RS00440 ENOG4105C6T cysteine synthase HT135_RS00445 ENOG4105CRQ synthase (Component I) HT135_RS00450 ENOG4105DDQ anthranilate synthase HT135_RS00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HT135_RS00460 ENOG4105EEI dihydropteroate synthase HT135_RS00465 ENOG4105KRF dihydroneopterin aldolase HT135_RS00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HT135_RS00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HT135_RS00485 ENOG4105CRK lysyL-tRNA synthetase HT135_RS00570 ENOG4108Z0C Uvrb UvrC protein HT135_RS00575 ENOG41066A3 ATP guanido phosphotransferase HT135_RS00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HT135_RS00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HT135_RS00595 ENOG4105CTP PilT protein domain protein HT135_RS00600 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HT135_RS00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HT135_RS00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HT135_RS00615 ENOG4105D7W serine acetyltransferase HT135_RS00620 ENOG4105C8N cysteinyl-tRNA synthetase HT135_RS00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HT135_RS00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 HT135_RS00635 ENOG4105M0M Tetracycline resistance protein HT135_RS00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HT135_RS00670 ENOG4108VZM 50s ribosomal protein L10 HT135_RS00680 ENOG4107Y49 methyltransferase HT135_RS00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HT135_RS00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HT135_RS00695 ENOG4105XPM ribosomal protein HT135_RS00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HT135_RS00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HT135_RS00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HT135_RS00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HT135_RS00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HT135_RS00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HT135_RS00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HT135_RS00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HT135_RS00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HT135_RS00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HT135_RS00765 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HT135_RS00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HT135_RS00780 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HT135_RS00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HT135_RS00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HT135_RS00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HT135_RS00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HT135_RS00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HT135_RS00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HT135_RS00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HT135_RS00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HT135_RS00850 ENOG41067V7 50S ribosomal protein L36 HT135_RS00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HT135_RS00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HT135_RS00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HT135_RS00870 ENOG4108ZT0 50S ribosomal protein l17 HT135_RS00875 ENOG4108JJB ABC transporter HT135_RS00880 ENOG4108JJB ABC transporter HT135_RS00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HT135_RS00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HT135_RS00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HT135_RS00900 ENOG4108UJD 30S ribosomal protein S9 HT135_RS00905 ENOG4108I0C methyltransferase HT135_RS00920 ENOG4105D1F ATP-binding protein HT135_RS00935 ENOG4108NMV polysaccharide deacetylase HT135_RS01015 ENOG4105CHH sulfate transporter HT135_RS01025 ENOG4108SA1 esterase HT135_RS01045 ENOG410874W AraC family transcriptional regulator HT135_RS01050 ENOG4105EHZ conserved protein UCP016719 HT135_RS01055 ENOG4105D17 glycoside hydrolase, family 3 domain protein HT135_RS01075 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HT135_RS01085 ENOG4105EWC Purine nucleoside phosphorylase HT135_RS01115 ENOG4105EMN RNA polymerase sigma factor HT135_RS01125 ENOG4105C8B TIGR00159 family HT135_RS01130 ENOG4107U5W ybbr family HT135_RS01135 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HT135_RS01145 ENOG4108TWJ NADH dehydrogenase subunit 5 HT135_RS01165 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HT135_RS01170 ENOG4105WAB arsR family transcriptional regulator HT135_RS01175 ENOG4108RWP Major Facilitator Superfamily protein HT135_RS01210 ENOG4105G0J serine threonine protein kinase HT135_RS01220 ENOG4106K80 HT135_RS01230 ENOG4106DDH Sporulation-specific SASP protein HT135_RS01240 ENOG4108HWY Beta-lactamase HT135_RS01245 ENOG4107E6A Cytochrome p-450 HT135_RS01255 ENOG4107QTZ amino acid HT135_RS01260 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HT135_RS01265 ENOG4105CXY transporter HT135_RS01275 ENOG410645S MarR family Transcriptional regulator HT135_RS01280 ENOG4105DCM major facilitator superfamily HT135_RS01290 ENOG410631K Membrane HT135_RS01295 ENOG4106AXJ AraC family transcriptional regulator HT135_RS01300 ENOG4107SCQ Iron-containing alcohol dehydrogenase HT135_RS01305 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HT135_RS01310 ENOG4108TCS Glutamyl endopeptidase HT135_RS01320 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HT135_RS01325 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HT135_RS01330 ENOG4107ZTW SNARE associated Golgi HT135_RS01355 ENOG4105C72 UPF0176 protein HT135_RS01365 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane HT135_RS01370 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HT135_RS01385 ENOG4105CM2 brancheD-chain amino acid aminotransferase HT135_RS01390 ENOG4108IQI permease HT135_RS01395 ENOG4108J5H Homocysteine s-methyltransferase HT135_RS01405 ENOG4105CSV Glutaminase HT135_RS01420 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HT135_RS01425 ENOG4105C26 Dehydrogenase HT135_RS01430 ENOG4105DJB Major Facilitator Superfamily HT135_RS01435 ENOG4105EQX glucarate dehydratase HT135_RS01440 ENOG41073TP transcriptional regulator HT135_RS01445 ENOG4105CTX dehydratase HT135_RS01460 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HT135_RS01495 ENOG4105MUA Resistance protein HT135_RS01505 ENOG4105DGI Alkaline phosphatase HT135_RS01510 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HT135_RS01515 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HT135_RS01520 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HT135_RS01525 ENOG4107EPV Aminotransferase class V HT135_RS01530 ENOG4105C0R drug resistance transporter emrb qaca subfamily HT135_RS01535 ENOG4105J7D transcriptional regulator HT135_RS01540 ENOG4107RB3 L-asparaginase HT135_RS01545 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HT135_RS01555 ENOG41060AI SEC-C motif HT135_RS01565 ENOG4107Y7X LytTR HT135_RS01570 ENOG4108IUW ABC transporter HT135_RS01575 ENOG4108SDH ABC, transporter HT135_RS01580 ENOG4107SET aldo keto reductase HT135_RS01615 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HT135_RS01625 ENOG4105DSE periplasmic solute binding protein HT135_RS01630 ENOG4105DIK (ABC) transporter HT135_RS01640 ENOG4105DEN Luciferase family HT135_RS01645 ENOG4108N0M stress protein HT135_RS01650 ENOG4106FN3 tellurium resistance protein HT135_RS01655 ENOG4106FN3 tellurium resistance protein HT135_RS01660 ENOG4107TS3 membrane protein, TerC HT135_RS01675 ENOG4105DAX Pfam:DUF2983 HT135_RS01685 ENOG4108TTB tellurium resistance protein HT135_RS01695 ENOG41079KZ Major Facilitator Superfamily HT135_RS01700 ENOG4107XZQ multidrug resistance protein HT135_RS01705 ENOG4108A65 Transcriptional regulator HT135_RS01710 ENOG4108IJ7 Glycine betaine HT135_RS01715 ENOG4107SQ8 Glycine betaine HT135_RS01745 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HT135_RS01785 ENOG4105EIG urea carboxylase-associated protein 1 HT135_RS01790 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HT135_RS01795 ENOG4105I1F Resistance protein HT135_RS01805 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HT135_RS01810 ENOG41089UC methyltransferase, type 11 HT135_RS01815 ENOG4105C5Q Transcriptional regulator HT135_RS01820 ENOG4105I82 acetyl xylan esterase HT135_RS01825 ENOG410756H nucleotidyltransferase HT135_RS01835 ENOG4105C26 Dehydrogenase HT135_RS01840 ENOG4105CK7 Sodium proline symporter HT135_RS01845 ENOG4107YHD transcriptional regulator HT135_RS01855 ENOG4108PJD permease HT135_RS01865 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HT135_RS01870 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HT135_RS01875 ENOG4108IFG nitrite reductase, (NAD(P)H) HT135_RS01880 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HT135_RS01900 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HT135_RS01910 ENOG4105CKI cobalamin synthesis protein HT135_RS01915 ENOG4105E5Q amino acid AbC transporter HT135_RS01920 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein HT135_RS01925 ENOG4105E2A Dehydrogenase HT135_RS01930 ENOG4105HHM rdd domain containing protein HT135_RS01940 ENOG4108VEN abc transporter atp-binding protein HT135_RS01945 ENOG4105CS2 ec 3.2.1.21 HT135_RS01960 ENOG4105C8Q Methyl-accepting chemotaxis HT135_RS01965 ENOG41080HJ 6-phospho 3-hexuloisomerase HT135_RS01970 ENOG4108VA3 3-hexulose-6-phosphate synthase HT135_RS01975 ENOG4105KVH Transcriptional regulator HT135_RS01980 ENOG4105CEY Amp-dependent synthetase and ligase HT135_RS02010 ENOG4105SX7 Transporter HT135_RS02030 ENOG4105CDA abc transporter atp-binding protein HT135_RS02035 ENOG4105DRP amino acid AbC transporter HT135_RS02045 ENOG4106P55 Transcriptional regulator HT135_RS02050 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HT135_RS02055 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HT135_RS02060 ENOG41069ZX HT135_RS02065 ENOG41069ZX HT135_RS02075 ENOG4105DUX Transporter HT135_RS02090 ENOG4105E1K spore germination protein HT135_RS02110 ENOG4107WD8 ABC transporter, permease HT135_RS02115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT135_RS02120 ENOG4105BZU Histidine kinase HT135_RS02145 ENOG4105CFH Aspartokinase HT135_RS02150 ENOG4105DHS permease protein HT135_RS02155 ENOG4105CM4 permease protein HT135_RS02160 ENOG4108IPW abc transporter atp-binding protein HT135_RS02175 ENOG4105R8C Transcriptional regulator HT135_RS02180 ENOG4108DBC nitroreductase HT135_RS02185 ENOG41067V3 Antibiotic biosynthesis monooxygenase HT135_RS02190 ENOG4105YVS arsR family transcriptional regulator HT135_RS02200 ENOG4108JPW Aminotransferase HT135_RS02205 ENOG4105C26 Dehydrogenase HT135_RS02215 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HT135_RS02220 ENOG4105KTB nuclear export factor GLE1 HT135_RS02225 ENOG4108T5E Copper resistance protein HT135_RS02230 ENOG4108ZYE Transcriptional regulator HT135_RS02255 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HT135_RS02280 ENOG4105E7W lamb ycsf family protein HT135_RS02285 ENOG4105C5A transporter HT135_RS02290 ENOG4105CFM UPF0317 protein HT135_RS02295 ENOG4105P4J Allophanate hydrolase, subunit 1 HT135_RS02305 ENOG4107258 Transcriptional regulator HT135_RS02310 ENOG4105XJB lipolytic protein G-D-S-L family HT135_RS02320 ENOG41061CK Antibiotic biosynthesis monooxygenase HT135_RS02325 ENOG4107RVG penicillin-binding protein HT135_RS02330 ENOG4107QM2 Aldo Keto reductase HT135_RS02335 ENOG4105ETD TRANSCRIPTIONal HT135_RS02345 ENOG4105HMZ Methyltransferase HT135_RS02350 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HT135_RS02365 ENOG410606W general stress protein HT135_RS02375 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HT135_RS02380 ENOG4105VCH membrane HT135_RS02390 ENOG4105C9U ATP-dependent DNA helicase RecQ HT135_RS02405 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HT135_RS02410 ENOG4107R8N Glycosyl transferase, family 2 HT135_RS02420 ENOG4105C0X amino acid HT135_RS02440 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HT135_RS02445 ENOG4107BMA Transglycosylase associated protein HT135_RS02450 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HT135_RS02455 ENOG4105EU9 HT135_RS02460 ENOG4105QVS general stress protein HT135_RS02465 ENOG41082W1 Cupin 2, conserved barrel domain protein HT135_RS02485 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HT135_RS02490 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HT135_RS02495 ENOG4108MRH transcriptional regulatory protein HT135_RS02500 ENOG4107QJT sodium dicarboxylate symporter HT135_RS02505 ENOG4106F5Q Membrane HT135_RS02515 ENOG4105CJ1 ABC, transporter HT135_RS02530 ENOG4105FDT acyl-CoA dehydrogenase HT135_RS02550 ENOG4105SZ6 Thioredoxin HT135_RS02555 ENOG4105CPF Cell wall formation (By similarity) HT135_RS02560 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HT135_RS02565 ENOG4105C1J atp-dependent rna helicase HT135_RS02570 ENOG410905X membrane-flanked domain protein HT135_RS02575 ENOG4105CKV Membrane HT135_RS02585 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HT135_RS02590 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HT135_RS02595 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HT135_RS02605 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HT135_RS02610 ENOG4107MMM Anti-sigma-factor antagonist HT135_RS02615 ENOG4105FUA antagonist HT135_RS02620 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HT135_RS02625 ENOG4107SGM protein serine threonine phosphatase HT135_RS02630 ENOG4105WN5 stage II sporulation protein HT135_RS02635 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HT135_RS02645 ENOG41064BQ Phosphatase HT135_RS02655 ENOG4105M5P UPF0310 protein HT135_RS02660 ENOG4105RV9 Transcriptional regulator HT135_RS02760 ENOG4105ECK Fatty Acid Desaturase HT135_RS02765 ENOG4105VEQ Cold shock protein HT135_RS02770 ENOG4105VEQ Cold shock protein HT135_RS02775 ENOG4108VJ1 Transcriptional regulator (CarD family HT135_RS02780 ENOG4105UNS Pfam:DUF419 HT135_RS02785 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_RS02805 ENOG4105CZ9 Domain of unknown function (DU1801) HT135_RS02810 ENOG4105GIG HT135_RS02825 ENOG4108U05 Transcriptional regulator HT135_RS02830 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HT135_RS02850 ENOG4108V4B ThiJ pfpI HT135_RS02865 ENOG4105T38 integral membrane protein HT135_RS02870 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HT135_RS02875 ENOG41085FC arsR family transcriptional regulator HT135_RS02880 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_RS02910 ENOG41090E6 transcriptional regulator MERR family HT135_RS02915 ENOG4105CGD Nad-dependent epimerase dehydratase HT135_RS02930 ENOG4105DM4 PTS System HT135_RS02935 ENOG4105DG6 mannose-6-phosphate isomerase HT135_RS02940 ENOG4108ZMQ domain protein HT135_RS02945 ENOG4107Y9U Membrane HT135_RS02955 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HT135_RS02960 ENOG4105Z7P Acetyltransferase (GNAT) family HT135_RS02975 ENOG4108TVJ Nitroreductase HT135_RS02980 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HT135_RS02985 ENOG4108VGI doxx family HT135_RS02990 ENOG4105XXY Thioredoxin HT135_RS02995 ENOG4105PF9 Transcriptional regulator HT135_RS03005 ENOG4105WQG acetyltransferase HT135_RS03015 ENOG4105CK5 oxidoreductase HT135_RS03020 ENOG4105ETE Transcriptional regulator (LacI family HT135_RS03025 ENOG4105C54 Major Facilitator superfamily HT135_RS03040 ENOG4105C85 amino acid HT135_RS03050 ENOG41062A4 Transcriptional regulator HT135_RS03055 ENOG4105EYF MMPL domain protein HT135_RS03065 ENOG4108TVJ Nitroreductase HT135_RS03070 ENOG4105FS7 Transcriptional regulator HT135_RS03075 ENOG4108JCI Transcriptional regulator HT135_RS03080 ENOG4108UMN azlc family HT135_RS03090 ENOG4105C2C drug resistance transporter, Bcr CflA HT135_RS03100 ENOG4105DRR Transcriptional regulator, GntR family HT135_RS03105 ENOG4105VRS hydrolase family 18 HT135_RS03125 ENOG4105G6Z alkaline phosphatase HT135_RS03130 ENOG4107TVP HD domain protein HT135_RS03135 ENOG41090UD (LipO)protein HT135_RS03140 ENOG4105F27 Major Facilitator HT135_RS03145 ENOG4105VZJ PTS System HT135_RS03150 ENOG4105VCP PTS System HT135_RS03155 ENOG4105CK1 PTS System HT135_RS03160 ENOG4105CS2 ec 3.2.1.21 HT135_RS03165 ENOG4108TZY GntR Family Transcriptional Regulator HT135_RS03170 ENOG4105EVU fructokinase HT135_RS03175 ENOG4105DG6 mannose-6-phosphate isomerase HT135_RS03180 ENOG4105D3P Mannan endo-1,4-beta-mannosidase HT135_RS03225 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HT135_RS03230 ENOG4105K8N protein family UPF0079, ATPase HT135_RS03235 ENOG41072GX Peptidase M22 Glycoprotease HT135_RS03240 ENOG410801F ribosomal-protein-alanine acetyltransferase HT135_RS03245 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HT135_RS03250 ENOG4105C5H ABC transporter HT135_RS03255 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HT135_RS03260 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HT135_RS03265 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HT135_RS03270 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HT135_RS03280 ENOG4108TYN CAAX amino terminal protease family protein HT135_RS03290 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HT135_RS03295 ENOG4105ESF Peptidoglycan binding domain protein HT135_RS03305 ENOG4105PGZ NB-ARC domain HT135_RS03310 ENOG4105CPQ Dehydrogenase HT135_RS03315 ENOG4105CT4 transporter HT135_RS03325 ENOG41087YS Phage shock protein A HT135_RS03330 ENOG4105DQX Zinc finger domain HT135_RS03335 ENOG4108WV1 Pfam:DUF477 HT135_RS03345 ENOG4108ZMR Ion transport 2 domain-containing protein HT135_RS03350 ENOG4107QNK )-transporter HT135_RS03380 ENOG4107YUH hydrolase HT135_RS03390 ENOG4107STQ Multicopper oxidase HT135_RS03395 ENOG4105C85 amino acid HT135_RS03405 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HT135_RS03435 ENOG4105C7N Xanthine uracil vitamin C permease HT135_RS03460 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HT135_RS03465 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HT135_RS03470 ENOG4105C83 adenylosuccinate lyase HT135_RS03475 ENOG4105C8V SAICAR synthetase HT135_RS03480 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HT135_RS03485 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HT135_RS03490 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HT135_RS03500 ENOG4105CXB phosphoribosylaminoimidazole synthetase HT135_RS03505 ENOG4108V3E phosphoribosylglycinamide formyltransferase HT135_RS03510 ENOG4105DC1 bifunctional purine biosynthesis protein purh HT135_RS03515 ENOG4105C12 Phosphoribosylglycinamide synthetase HT135_RS03525 ENOG4105DVH amino acid HT135_RS03540 ENOG4108R5T secreted protein HT135_RS03545 ENOG4105KGF protein, YerC YecD HT135_RS03550 ENOG4105CBC glutamate synthase HT135_RS03555 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HT135_RS03560 ENOG4105C4R Atp-dependent dna helicase HT135_RS03565 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HT135_RS03575 ENOG4105CRN Aminoglycoside phosphotransferase HT135_RS03580 ENOG4105KT7 mgtC SapB transporter HT135_RS03585 ENOG4105CK7 Sodium proline symporter HT135_RS03590 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HT135_RS03595 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HT135_RS03600 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HT135_RS03605 ENOG4108IG5 Transcriptional regulator HT135_RS03615 ENOG4105CBD Diacylglycerol kinase HT135_RS03620 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HT135_RS03695 ENOG4105CDY transcriptional regulatory protein HT135_RS03710 ENOG4105M4P Tetr family transcriptional regulator HT135_RS03715 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HT135_RS03720 ENOG4107S9F NmrA family HT135_RS03725 ENOG4105KHM amidohydrolase 2 HT135_RS03730 ENOG4105ST3 Transcriptional regulator HT135_RS03745 ENOG4105WEF catalase HT135_RS03750 ENOG4105M18 -acetyltransferase HT135_RS03765 ENOG4105C2F Histidine kinase HT135_RS03770 ENOG4105EQD regulatoR HT135_RS03775 ENOG410769Z extracellular solute-binding protein family 1 HT135_RS03780 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HT135_RS03785 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HT135_RS03790 ENOG4105F5H Glycosyl Hydrolase Family 88 HT135_RS03795 ENOG41075H3 AraC family transcriptional regulator HT135_RS03800 ENOG4107TDE lipolytic protein G-D-S-L family HT135_RS03815 ENOG4105CX8 fg-gap repeat protein HT135_RS03820 ENOG4105CX8 fg-gap repeat protein HT135_RS03825 ENOG4105CPC Aldo Keto reductase HT135_RS03830 ENOG4107TDE lipolytic protein G-D-S-L family HT135_RS03840 ENOG4105EKC HT135_RS03845 ENOG4105E0S extracellular solute-binding protein family 1 HT135_RS03855 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HT135_RS03860 ENOG4105F8D glycoside hydrolase family 4 HT135_RS03865 ENOG4105H67 Protein of unknown function (DUF421) HT135_RS03870 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HT135_RS03875 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HT135_RS03895 ENOG4106I4J membrane HT135_RS03900 ENOG41082F9 transcriptional regulator HT135_RS03905 ENOG41061H0 Monooxygenase HT135_RS03910 ENOG4108R1P HT135_RS03915 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HT135_RS03920 ENOG4105E0M Sulfatase HT135_RS03925 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HT135_RS03935 ENOG41090R9 glycosyltransferase HT135_RS03940 ENOG4107R51 Glycosyl transferase, family 2 HT135_RS03945 ENOG41090R9 glycosyltransferase HT135_RS03950 ENOG4105EU0 Major facilitator Superfamily HT135_RS03960 ENOG4105CUB amino acid HT135_RS03965 ENOG4105C26 Dehydrogenase HT135_RS03970 ENOG4105FKZ Methyl-accepting chemotaxis HT135_RS03975 ENOG4105C5H ABC transporter HT135_RS03985 ENOG4107SWG transcriptional regulator MERR family HT135_RS03990 ENOG4105DXB Major Facilitator superfamily HT135_RS04000 ENOG4105C5H ABC transporter HT135_RS04005 ENOG4105FDU atp-dependent rna helicase HT135_RS04015 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HT135_RS04020 ENOG4105E0A ABC, transporter HT135_RS04025 ENOG4108U1V ABC transporter, permease HT135_RS04030 ENOG4105DQ5 transport system permease protein HT135_RS04035 ENOG4108HUF Transporter HT135_RS04050 ENOG4108J20 pectate lyase HT135_RS04055 ENOG4107QPK )-transporter HT135_RS04075 ENOG4106WTF Glycosyl transferase, family 2 HT135_RS04080 ENOG4107RGC Glycosyl transferase, family 2 HT135_RS04090 ENOG4108MRH transcriptional regulatory protein HT135_RS04115 ENOG410855V Acylphosphatase HT135_RS04120 ENOG4108RPX mosc domain containing protein HT135_RS04140 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HT135_RS04165 ENOG4105C5Y PTS System HT135_RS04170 ENOG4105CG3 alpha amylase, catalytic region HT135_RS04175 ENOG4107414 GntR family transcriptional regulator HT135_RS04180 ENOG4108RCM Nitroreductase HT135_RS04185 ENOG4105CGH 5'-nucleotidase HT135_RS04190 ENOG4107RKG DJ-1/PfpI family HT135_RS04205 ENOG4105KJF protein tyrosine phosphatase HT135_RS04215 ENOG4107U9T Pfam:Ribonuclease_BN HT135_RS04220 ENOG4108ISG Major Facilitator HT135_RS04225 ENOG4105UPD Calcium Proton HT135_RS04235 ENOG4105D8X mechanosensitive ion channel HT135_RS04260 ENOG4106KE4 Dehydrogenase HT135_RS04265 ENOG4105D7N magnesium and cobalt transport protein CorA HT135_RS04275 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HT135_RS04285 ENOG4105BZ1 (ABC) transporter HT135_RS04290 ENOG4105CJA serine threonine protein kinase HT135_RS04310 ENOG4105CFC Transporter HT135_RS04340 ENOG4107RUY (E1 component), alpha subunit HT135_RS04350 ENOG4107QKR Dehydrogenase HT135_RS04360 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HT135_RS04365 ENOG41069DP small acid-soluble spore protein HT135_RS04370 ENOG4105KK4 UPF0060 membrane protein HT135_RS04400 ENOG4105F8D glycoside hydrolase family 4 HT135_RS04405 ENOG4108Q3X Transcriptional regulator HT135_RS04410 ENOG4105CI1 PTS System HT135_RS04415 ENOG4105BZ1 (ABC) transporter HT135_RS04420 ENOG4105BZ1 (ABC) transporter HT135_RS04430 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_RS04435 ENOG4105ID8 Transcriptional regulator, ARAC family HT135_RS04440 ENOG4107QNK )-transporter HT135_RS04445 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HT135_RS04450 ENOG4105CIB oxidoreductase Domain protein HT135_RS04455 ENOG4105BZU Histidine kinase HT135_RS04460 ENOG4105WH1 Two component transcriptional regulator luxr family HT135_RS04465 ENOG4105CJ1 ABC, transporter HT135_RS04470 ENOG41090VJ ABC-2 type transporter HT135_RS04475 ENOG4108KYE ABC-2 type transporter HT135_RS04480 ENOG4105U3E Transcriptional regulator HT135_RS04485 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HT135_RS04490 ENOG4105H93 Acyltransferase family HT135_RS04495 ENOG4108YYS metal-dependent hydrolase (By similarity) HT135_RS04500 ENOG4105C0R drug resistance transporter emrb qaca subfamily HT135_RS04505 ENOG410834F Transcriptional regulator HT135_RS04515 ENOG4108MES Periplasmic binding protein HT135_RS04520 ENOG4105DQ5 transport system permease protein HT135_RS04525 ENOG4108IHU transport system permease protein HT135_RS04530 ENOG4105JAB phenazine biosynthesis protein, phzf family HT135_RS04535 ENOG4107Y03 Nitroreductase HT135_RS04550 ENOG4105ECP epimerase HT135_RS04565 ENOG4105F27 Major Facilitator HT135_RS04580 ENOG4105VZ8 Transcriptional regulator HT135_RS04590 ENOG4106AKJ HT135_RS04595 ENOG4105D74 hydrolase HT135_RS04600 ENOG4105CKK Glycosyl transferase, family 2 HT135_RS04605 ENOG4105EJV Membrane HT135_RS04610 ENOG41067AE Membrane-bound metal-dependent hydrolase HT135_RS04615 ENOG4105CEN a g-specific adenine glycosylase HT135_RS04620 ENOG4106BXE HT135_RS04625 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HT135_RS04640 ENOG4105EVI UPF0374 protein HT135_RS04645 ENOG4105BZ1 (ABC) transporter HT135_RS04650 ENOG4107NBY Membrane HT135_RS04660 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HT135_RS04665 ENOG4105G5W regulator Fur family HT135_RS04775 ENOG4108N23 SpoOM-related protein HT135_RS04785 ENOG4105E2A Dehydrogenase HT135_RS04790 ENOG4105PGS Spore coat protein HT135_RS04805 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HT135_RS04820 ENOG4105E2Y ABC, transporter HT135_RS04825 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HT135_RS04830 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HT135_RS04835 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HT135_RS04845 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HT135_RS04850 ENOG4107D63 HT135_RS04855 ENOG4105VZ8 Transcriptional regulator HT135_RS04870 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HT135_RS04880 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HT135_RS04900 ENOG4105CYN Serine protein kinase HT135_RS04905 ENOG4106AKX UPF0229 protein HT135_RS04910 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HT135_RS04915 ENOG4105CW7 secretion protein, HlyD family HT135_RS04920 ENOG4105C0R drug resistance transporter emrb qaca subfamily HT135_RS04925 ENOG4105CS1 NAD(P)H quinone oxidoreductase HT135_RS04940 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HT135_RS04945 ENOG4105CZV ABC transporter HT135_RS04950 ENOG4105CJ1 ABC, transporter HT135_RS04955 ENOG4108TU7 Inherit from COG: (ABC) transporter HT135_RS04960 ENOG4105VEQ Cold shock protein HT135_RS04970 ENOG4105BZU Histidine kinase HT135_RS05010 ENOG4108YBP pseudouridine synthase HT135_RS05020 ENOG41080XP Cbs domain HT135_RS05025 ENOG4107YBY Hydrolase HT135_RS05030 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HT135_RS05040 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT135_RS05045 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HT135_RS05055 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HT135_RS05060 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HT135_RS05070 ENOG4105BZU Histidine kinase HT135_RS05075 ENOG4105WH1 Two component transcriptional regulator luxr family HT135_RS05110 ENOG4105ED1 spovr family HT135_RS05115 ENOG4105G6Z alkaline phosphatase HT135_RS05130 ENOG4105BZN citrate synthase HT135_RS05135 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HT135_RS05140 ENOG4105CUB amino acid HT135_RS05145 ENOG4105C8J )-transporter HT135_RS05150 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HT135_RS05165 ENOG4105J37 HT135_RS05170 ENOG4108AEY RNA polymerase sigma factor HT135_RS05175 ENOG4108FN7 Aldo keto reductase HT135_RS05180 ENOG4105F6E Acyl-transferase HT135_RS05185 ENOG4107VFR oxidoreductase HT135_RS05190 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HT135_RS05195 ENOG4105C37 (CBS) domain HT135_RS05205 ENOG4105CHM Aminotransferase HT135_RS05210 ENOG4105C37 (CBS) domain HT135_RS05220 ENOG4105WMR Protein CrcB homolog HT135_RS05225 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HT135_RS05235 ENOG4105D64 Mechanosensitive ion channel HT135_RS05240 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HT135_RS05245 ENOG4107VMI polysaccharide deacetylase HT135_RS05250 ENOG4105F0I Aminotransferase HT135_RS05270 ENOG4105BZ1 (ABC) transporter HT135_RS05275 ENOG4105BZ1 (ABC) transporter HT135_RS05300 ENOG410839P HT135_RS05310 ENOG4106MP8 UPF0754 membrane protein HT135_RS05315 ENOG4105WZB UPF0342 protein HT135_RS05320 ENOG4105F1N DNA alkylation repair HT135_RS05330 ENOG4105D4P Coproporphyrinogen iii oxidase HT135_RS05335 ENOG4107S91 Sodium hydrogen exchanger HT135_RS05340 ENOG4105NCW Trka-c domain protein HT135_RS05350 ENOG4105CGU Enoyl-CoA hydratase HT135_RS05360 ENOG4108IUX (ABC) transporter HT135_RS05365 ENOG4105RHA ABC transporter, permease HT135_RS05370 ENOG4107VRP DNA repair exonuclease HT135_RS05375 ENOG4106D4I domain protein HT135_RS05380 ENOG4105EQI Metal Dependent Phosphohydrolase HT135_RS05390 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HT135_RS05435 ENOG4105NBU tryptophan transport protein HT135_RS05440 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HT135_RS05445 ENOG4105K59 histidine triad (HIT) protein HT135_RS05480 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HT135_RS05485 ENOG4105BZ4 penicillin-binding protein HT135_RS05490 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HT135_RS05495 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HT135_RS05500 ENOG4105C1Q protoporphyrinogen oxidase HT135_RS05510 ENOG4105ECB domain protein HT135_RS05520 ENOG41090T1 Membrane HT135_RS05525 ENOG4105DER m42 family HT135_RS05540 ENOG4106AXD HT135_RS05545 ENOG4108RQ5 Beta-lactamase domain-containing protein HT135_RS05550 ENOG4105DF9 Lipoate-protein, ligase HT135_RS05560 ENOG4105CEY Amp-dependent synthetase and ligase HT135_RS05570 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HT135_RS05575 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_RS05580 ENOG4105KD7 acetyltransferase HT135_RS05590 ENOG4108HUF Transporter HT135_RS05595 ENOG4107TB6 phosphoglycerate mutase HT135_RS05605 ENOG4107F3J Amp-dependent synthetase and ligase HT135_RS05610 ENOG4107ZYJ bioY protein HT135_RS05615 ENOG4106YBV Methyl-accepting chemotaxis HT135_RS05635 ENOG4105XVF Competence transcription factor HT135_RS05645 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HT135_RS05650 ENOG4105X3H Excalibur domain protein HT135_RS05655 ENOG4105E1V na solute symporter HT135_RS05660 ENOG4106CAD Protein of unknown function (DUF3311) HT135_RS05665 ENOG41060YP HT135_RS05680 ENOG4107SCK Monooxygenase HT135_RS05685 ENOG4108INS Transcriptional regulator HT135_RS05705 ENOG4105TRI Hydrolase HT135_RS05720 ENOG4108KK1 membrane protein AbrB duplication HT135_RS05725 ENOG4106K7D Major facilitator family transporter HT135_RS05730 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HT135_RS05735 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding HT135_RS05750 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HT135_RS05760 ENOG4105EYH Exonuclease HT135_RS05810 ENOG4105ERH Fumarylacetoacetate hydrolase HT135_RS05820 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_RS05830 ENOG4105CAQ asparagine synthetase HT135_RS05845 ENOG4105UQX Mate efflux family protein HT135_RS05850 ENOG4106HBX Transcriptional Regulator AraC Family HT135_RS05855 ENOG4105ETE Transcriptional regulator (LacI family HT135_RS05860 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HT135_RS05865 ENOG4105SF0 DinB family HT135_RS05870 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HT135_RS05875 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HT135_RS05880 ENOG4105MYW Pentapeptide repeat protein HT135_RS05885 ENOG4107S9D Alpha beta hydrolase HT135_RS05890 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HT135_RS05895 ENOG4107RIQ Sulfate adenylate transferase HT135_RS05900 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HT135_RS05905 ENOG4108N5B 2-phosphosulfolactate phosphatase HT135_RS05910 ENOG41061P3 phosphosulfolactate synthase HT135_RS05920 ENOG4105DIA mandelate racemase muconate lactonizing HT135_RS05925 ENOG4107RCC Major Facilitator Superfamily HT135_RS05930 ENOG4108SZE gCN5-related N-acetyltransferase HT135_RS05935 ENOG4105MA6 gCN5-related N-acetyltransferase HT135_RS05945 ENOG4108VPT UPF0234 protein HT135_RS05950 ENOG4105QNR S1 RNA binding domain protein HT135_RS05970 ENOG4105K7K Transcriptional regulator HT135_RS05980 ENOG410751J HT135_RS05985 ENOG4105D4Y metalloprotease HT135_RS05990 ENOG4105EPR degv family HT135_RS05995 ENOG4107AYK membrAne HT135_RS06005 ENOG41073B9 HT135_RS06015 ENOG4108KP7 hydrolase HT135_RS06020 ENOG4108MXZ Esterase HT135_RS06025 ENOG4105VG1 fes assembly suf system protein HT135_RS06035 ENOG4105IQ5 FAD linked oxidase domain protein HT135_RS06045 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HT135_RS06050 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HT135_RS06060 ENOG4105C8Y Acetylornithine aminotransferase HT135_RS06065 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HT135_RS06075 ENOG4105DBV ornithine carbamoyltransferase HT135_RS06100 ENOG4107RMD Basic membrane lipoprotein HT135_RS06115 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HT135_RS06120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HT135_RS06130 ENOG4105C3U ABC transporter HT135_RS06135 ENOG4108JQ7 (ABC) transporter HT135_RS06150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT135_RS06160 ENOG4105C31 Tryptophanyl-tRNA synthetase HT135_RS06165 ENOG4108J59 Extracellular solute-binding protein, family 5 HT135_RS06170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT135_RS06175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT135_RS06185 ENOG4108JQ7 (ABC) transporter HT135_RS06200 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HT135_RS06205 ENOG4108ZCF integral membrane protein HT135_RS06215 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HT135_RS06225 ENOG4105DPN Oligoendopeptidase f HT135_RS06235 ENOG4105T58 Dithiol-disulfide isomerase HT135_RS06240 ENOG4108Z18 K06886 hemoglobin HT135_RS06245 ENOG4105E4C Lytic transglycosylase catalytic HT135_RS06250 ENOG4105MIX Adenylate cyclase HT135_RS06265 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HT135_RS06270 ENOG4105EMS pseudouridine synthase HT135_RS06285 ENOG4105ETU transcriptional activator (TenA HT135_RS06290 ENOG4108VEU Thiamine monophosphate synthase HT135_RS06305 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HT135_RS06310 ENOG4105D06 uba thif-type nad fad binding protein HT135_RS06315 ENOG4105DWF phosphomethylpyrimidine kinase HT135_RS06320 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HT135_RS06325 ENOG4107A88 HT135_RS06375 ENOG4105ENA helicase HT135_RS06390 ENOG4108ZMI UPF0477 protein HT135_RS06400 ENOG4105C28 cystathionine HT135_RS06405 ENOG4105C28 cystathionine HT135_RS06410 ENOG4105D9U N-acetyltransferase HT135_RS06415 ENOG4105JHY Membrane HT135_RS06425 ENOG4105VTR Integrase HT135_RS06440 ENOG4108ZUE Phage regulatory protein rha HT135_RS06445 ENOG4107D0N HT135_RS06560 ENOG4108FKH Transglycosylase SLT domain HT135_RS06575 ENOG410651K Teichoic acid biosynthesis protein C HT135_RS06580 ENOG41068G1 HT135_RS06600 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HT135_RS06660 ENOG4106BHF HT135_RS06705 ENOG41083Q9 chitosanase HT135_RS06720 ENOG4105G7B Protein of unknown function (DUF2992) HT135_RS06725 ENOG4105VMI -acetyltransferase HT135_RS06730 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HT135_RS06745 ENOG4107TXC Transcriptional regulator HT135_RS06765 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HT135_RS06775 ENOG4108ZJ4 polysaccharide deacetylase HT135_RS06780 ENOG4107CUJ Protein of unknown function (DUF2690) HT135_RS06805 ENOG4108IEG Formate dehydrogenase Alpha subunit HT135_RS06830 ENOG4106A3M Cytochrome p-450 HT135_RS06835 ENOG41087PP glycosyltransferase MGT family HT135_RS06850 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HT135_RS06855 ENOG4105C4B ABC transporter, permease HT135_RS06860 ENOG4108IXI (ABC) transporter HT135_RS06870 ENOG4105Q95 Cupin 2, conserved barrel domain protein HT135_RS06885 ENOG4105D2H Uronic isomerase HT135_RS06890 ENOG4105CT4 transporter HT135_RS06895 ENOG4105DG4 malate L-lactate dehydrogenase HT135_RS06900 ENOG4105CPQ Dehydrogenase HT135_RS06905 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HT135_RS06910 ENOG4105DMW Dehydrogenase reductase HT135_RS06915 ENOG4108I5G Major Facilitator superfamily HT135_RS06920 ENOG4107KJX Transcriptional regulator HT135_RS06925 ENOG4107QZW Altronate oxidoreductase HT135_RS06930 ENOG4105CTX dehydratase HT135_RS06935 ENOG4107TSN permease HT135_RS06955 ENOG41068K0 YCII-related domain HT135_RS06960 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HT135_RS06970 ENOG4105K7W phage-related replication protein HT135_RS06975 ENOG4105WEF catalase HT135_RS06980 ENOG410635T phage-like element pbsx protein HT135_RS07025 ENOG4108TFU terminase (Small subunit) HT135_RS07030 ENOG4105IG6 Phage terminase, large subunit HT135_RS07035 ENOG4108MDF Phage Portal Protein HT135_RS07060 ENOG41060SN HT135_RS07075 ENOG4105PQS phage protein HT135_RS07080 ENOG4105FR7 XkdM protein, phage-like element PBSX HT135_RS07085 ENOG4105MTC XkdN-like protein HT135_RS07095 ENOG4108FKH Transglycosylase SLT domain HT135_RS07100 ENOG4108WZM domain protein HT135_RS07105 ENOG4105X7F HT135_RS07115 ENOG4105MFU Protein of unknown function (DUF2634) HT135_RS07120 ENOG41066EA baseplate J family protein HT135_RS07125 ENOG410906S phage-like element pbsx protein xkdt HT135_RS07135 ENOG41068G1 HT135_RS07165 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HT135_RS07185 ENOG4105CJ3 phosphate transporter HT135_RS07190 ENOG4107GRR phosphate transport regulator HT135_RS07195 ENOG4107R7I amino acid HT135_RS07205 ENOG4105EDW glycosyl transferase, family 39 HT135_RS07210 ENOG4105CKK Glycosyl transferase, family 2 HT135_RS07220 ENOG4105C0H protease HT135_RS07230 ENOG4108ME1 Peptidase M55 D-aminopeptidase HT135_RS07235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT135_RS07240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT135_RS07245 ENOG4105C3U ABC transporter HT135_RS07255 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HT135_RS07260 ENOG4105DTQ mandelate racemase muconate lactonizing HT135_RS07265 ENOG4107SN7 NLP P60 protein HT135_RS07270 ENOG4108JQ7 (ABC) transporter HT135_RS07275 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HT135_RS07280 ENOG4107TUM Amidinotransferase HT135_RS07285 ENOG4108S4H thioesterase Superfamily protein HT135_RS07290 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HT135_RS07310 ENOG4108428 Inherit from COG: -acetyltransferase HT135_RS07320 ENOG41080TC multidrug resistance protein HT135_RS07325 ENOG4105CIY formyltetrahydrofolate deformylase HT135_RS07330 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HT135_RS07345 ENOG4105K56 Transcriptional regulator HT135_RS07350 ENOG4108ZHJ Organic hydroperoxide resistance protein HT135_RS07355 ENOG4107TVC Glycosyl transferase, family 2 HT135_RS07360 ENOG4107Y2X deaminase HT135_RS07365 ENOG4105CVJ phosphoglycerate mutase HT135_RS07370 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HT135_RS07375 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_RS07385 ENOG4108W7F transporter, permease HT135_RS07390 ENOG4108JJB ABC transporter HT135_RS07395 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HT135_RS07400 ENOG4108X43 YKOF domain protein HT135_RS07405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT135_RS07410 ENOG41062D9 Histidine kinase HT135_RS07420 ENOG4106849 propeptide, pepSY amd peptidase M4 HT135_RS07430 ENOG4105CJW magnesium transporter HT135_RS07435 ENOG4105V75 Transcriptional regulator HT135_RS07480 ENOG4105DQE DNA ligase HT135_RS07485 ENOG4105FDF Could be involved in DNA repair (By similarity) HT135_RS07490 ENOG4105BZU Histidine kinase HT135_RS07495 ENOG4107T5V SNARE associated Golgi HT135_RS07500 ENOG4107TS3 membrane protein, TerC HT135_RS07505 ENOG4108WZW RNA polymerase sigma HT135_RS07515 ENOG410681C small acid-soluble spore protein HT135_RS07525 ENOG4105D0M Protease HtpX homolog HT135_RS07545 ENOG4108TGC Acyltransferase HT135_RS07550 ENOG4105BZU Histidine kinase HT135_RS07555 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HT135_RS07565 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HT135_RS07570 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HT135_RS07575 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HT135_RS07585 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit HT135_RS07590 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HT135_RS07595 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HT135_RS07600 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HT135_RS07620 ENOG4105BZU Histidine kinase HT135_RS07625 ENOG41090MY MarR family Transcriptional regulator HT135_RS07630 ENOG4105ER2 Ompa motb domain protein HT135_RS07635 ENOG4105E14 MotA TolQ exbB proton channel HT135_RS07645 ENOG4108K88 Membrane HT135_RS07650 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HT135_RS07655 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HT135_RS07660 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HT135_RS07665 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HT135_RS07670 ENOG4105FEA Spore maturation protein HT135_RS07700 ENOG4105F0V Cell wall hydrolase HT135_RS07715 ENOG4105C59 p-type ATPase HT135_RS07725 ENOG4105DC7 peptidase M24 HT135_RS07735 ENOG4105CID antiterminator HT135_RS07745 ENOG4105KRI phosphocarrier protein (HPr HT135_RS07750 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HT135_RS07760 ENOG4105F6S Spore photoproduct lyase HT135_RS07770 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HT135_RS07775 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HT135_RS07780 ENOG4105K4I Scp-like extracellular HT135_RS07790 ENOG4105BZU Histidine kinase HT135_RS07795 ENOG4105CHM Aminotransferase HT135_RS07805 ENOG4107R88 Chemotaxis protein (CheV) HT135_RS07810 ENOG4105UIN HT135_RS07820 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HT135_RS07830 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HT135_RS07835 ENOG4105EPM Diguanylate phosphodiesterase HT135_RS07840 ENOG4105WEF catalase HT135_RS07845 ENOG4107IN1 Protein of unknown function (DUF1797) HT135_RS07850 ENOG4108XRC Protein of unknown function (DUF458) HT135_RS07880 ENOG4105NQC Flavodoxin HT135_RS07890 ENOG4105CH2 amidohydrolase HT135_RS07900 ENOG4105D8X mechanosensitive ion channel HT135_RS07905 ENOG4105D3R alkyl hydroperoxide reductase HT135_RS07910 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HT135_RS07925 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HT135_RS07930 ENOG4105D06 uba thif-type nad fad binding protein HT135_RS07935 ENOG4105CVM Molybdenum cofactor synthesis domain protein HT135_RS07940 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HT135_RS07945 ENOG4108ZAF Molybdopterin HT135_RS07950 ENOG41067WU Molybdopterin converting factor (Subunit 1) HT135_RS07955 ENOG4105BZ1 (ABC) transporter HT135_RS07960 ENOG4105BZ1 (ABC) transporter HT135_RS07970 ENOG4107X8C Efflux transporter RND family MFP subunit HT135_RS07975 ENOG4105C19 ABC transporter HT135_RS07980 ENOG4107RBB ABC transporter, permease HT135_RS07985 ENOG4105E98 transcriptional regulator DeoR family HT135_RS07990 ENOG4105DE4 1-phosphofructokinase HT135_RS07995 ENOG4105DM4 PTS System HT135_RS08000 ENOG4105C3F Signal peptidase i HT135_RS08010 ENOG4105C5H ABC transporter HT135_RS08015 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HT135_RS08040 ENOG4105BZU Histidine kinase HT135_RS08050 ENOG4107ZYR domain protein HT135_RS08060 ENOG4105CN5 Metallo-Beta-Lactamase HT135_RS08070 ENOG4108X4Q Hydrolase HT135_RS08075 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HT135_RS08095 ENOG4105CPP Dehydrogenase, E1 component HT135_RS08100 ENOG4105C7S Dehydrogenase HT135_RS08105 ENOG4107QN2 dihydrolipoyl dehydrogenase HT135_RS08120 ENOG4105CXN decarboxylase HT135_RS08125 ENOG4105WBI UPF0223 protein HT135_RS08140 ENOG4105ECY inositol monophosphatase HT135_RS08150 ENOG4105JQZ Methyltransferase HT135_RS08190 ENOG4105CI3 gtp-binding protein typa HT135_RS08195 ENOG4105QA2 HT135_RS08210 ENOG4108IAB Phoh family HT135_RS08220 ENOG4105CSV Glutaminase HT135_RS08225 ENOG4105ZPI UPF0358 protein HT135_RS08230 ENOG4105CNI cell division protein FtsW HT135_RS08235 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HT135_RS08245 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HT135_RS08255 ENOG4105BZ9 Cytochrome C oxidase, subunit I HT135_RS08260 ENOG4105CCU oxidase (Subunit III) HT135_RS08265 ENOG41064X9 cytochrome C oxidase subunit IV HT135_RS08280 ENOG41080XQ Signal transduction protein with cbs domains HT135_RS08285 ENOG4106UY4 Inherit from COG: Scp-like extracellular HT135_RS08305 ENOG4105WUC UPF0298 protein HT135_RS08310 ENOG4106H78 methyltransferase HT135_RS08315 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HT135_RS08320 ENOG4105H20 Sporulation integral membrane protein YlbJ HT135_RS08325 ENOG4105D78 K07001 NTE family protein HT135_RS08330 ENOG41063PX domain protein HT135_RS08340 ENOG4105CDE UPF0348 protein HT135_RS08345 ENOG4105KNH Nucleic acid-binding protein HT135_RS08375 ENOG4108V6E Cell division protein mraZ HT135_RS08380 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HT135_RS08390 ENOG4105CJN penicillin-binding protein HT135_RS08395 ENOG4105CJN penicillin-binding protein HT135_RS08400 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HT135_RS08405 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HT135_RS08410 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HT135_RS08415 ENOG4105CNI cell division protein FtsW HT135_RS08420 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HT135_RS08425 ENOG4105D4A Cell wall formation (By similarity) HT135_RS08430 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HT135_RS08435 ENOG4108R2U division initiation protein HT135_RS08445 ENOG4105K67 small basic protein HT135_RS08450 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HT135_RS08455 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HT135_RS08465 ENOG4105FFI sigma-e processing peptidase spoiiga HT135_RS08470 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_RS08480 ENOG4105DKW ABC transporter HT135_RS08490 ENOG4105WR5 sporulation protein, YlmC YmxH family HT135_RS08495 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HT135_RS08500 ENOG4105DFA alanine racemase domain protein HT135_RS08505 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HT135_RS08510 ENOG41067XK integral membrane protein HT135_RS08515 ENOG4105DBK s4 domain protein HT135_RS08525 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HT135_RS08535 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HT135_RS08540 ENOG4105C34 Pseudouridine synthase HT135_RS08545 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HT135_RS08555 ENOG4105CXT aspartate transcarbamylase HT135_RS08565 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HT135_RS08570 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HT135_RS08575 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HT135_RS08580 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HT135_RS08585 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HT135_RS08590 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HT135_RS08595 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HT135_RS08605 ENOG4107S4M Sulfate adenylate transferase HT135_RS08610 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HT135_RS08615 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HT135_RS08620 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HT135_RS08625 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HT135_RS08640 ENOG4105DSJ YicC domain protein HT135_RS08645 ENOG4105KC4 UPF0296 protein HT135_RS08650 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HT135_RS08660 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HT135_RS08665 ENOG4105C25 Primosomal protein n' HT135_RS08670 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HT135_RS08675 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HT135_RS08680 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HT135_RS08685 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HT135_RS08690 ENOG4108ZF3 Phosphatase HT135_RS08695 ENOG4105D9P serine threonine protein kinase HT135_RS08700 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HT135_RS08705 ENOG4105DJV ribulose-phosphate 3-epimerase HT135_RS08710 ENOG4105FJ0 thiamine HT135_RS08720 ENOG4105VB9 50S ribosomal protein l28 HT135_RS08725 ENOG4108ZAA Alkaline-shock protein HT135_RS08730 ENOG4105DP4 dak2 domain fusion protein ylov HT135_RS08740 ENOG4105EJQ L-serine dehydratase HT135_RS08745 ENOG4105CB5 ATP-dependent DNA helicase recG HT135_RS08750 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HT135_RS08760 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HT135_RS08765 ENOG4105CHR reductase HT135_RS08775 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HT135_RS08780 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HT135_RS08785 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HT135_RS08795 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HT135_RS08805 ENOG4105K5M 30s ribosomal protein S16 HT135_RS08810 ENOG4108BW8 UPF0109 protein HT135_RS08820 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HT135_RS08825 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HT135_RS08830 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HT135_RS08835 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HT135_RS08840 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HT135_RS08850 ENOG4105VM1 flagellar HT135_RS08855 ENOG4105CMV Succinyl-CoA synthetase subunit beta HT135_RS08860 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HT135_RS08865 ENOG4105C79 DNA protecting protein DprA HT135_RS08870 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HT135_RS08875 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HT135_RS08880 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HT135_RS08885 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HT135_RS08890 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HT135_RS08900 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HT135_RS08905 ENOG4108ZC9 flagellar basal-body rod protein flgc HT135_RS08910 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HT135_RS08915 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HT135_RS08920 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HT135_RS08935 ENOG4106YF4 Flagellar biosynthesis chaperone HT135_RS08945 ENOG410696Y Flagellar hook-length control protein HT135_RS08950 ENOG410822I Flagellar hook capping protein HT135_RS08955 ENOG4108JQA flagellar HT135_RS08960 ENOG41068WV flagellar FlbD family protein HT135_RS08970 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HT135_RS08975 ENOG4105DD5 Flagellar motor switch protein HT135_RS08980 ENOG4107YTP response regulator receiver protein HT135_RS08990 ENOG4105CN7 Flagellar biosynthetic protein FliP HT135_RS08995 ENOG4105VS8 Flagellar biosynthetic protein fliq HT135_RS09000 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HT135_RS09005 ENOG4105D00 flagellar biosynthetic protein flhB HT135_RS09010 ENOG4105D7B Flagellar biosynthesis protein flha HT135_RS09015 ENOG4105FZW flagellar biosynthesis regulator FlhF HT135_RS09025 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HT135_RS09030 ENOG4105CBS Chea signal transduction histidine kinase HT135_RS09035 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HT135_RS09050 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_RS09060 ENOG4105CE9 30S ribosomal protein S2 HT135_RS09065 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HT135_RS09075 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HT135_RS09080 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HT135_RS09085 ENOG4105KNE Phosphatidate cytidylyltransferase HT135_RS09095 ENOG4105DZP Membrane-associated zinc metalloprotease HT135_RS09100 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HT135_RS09105 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HT135_RS09110 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HT135_RS09115 ENOG4105CHV Transcription elongation factor NusA HT135_RS09120 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HT135_RS09125 ENOG4105VHM ribosomal protein HT135_RS09130 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HT135_RS09135 ENOG4105W7A Protein of unknown function (DUF503) HT135_RS09140 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HT135_RS09145 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HT135_RS09150 ENOG4105DTN riboflavin biosynthesis protein ribF HT135_RS09155 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HT135_RS09160 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HT135_RS09170 ENOG4105C1V Peptidase, M16 HT135_RS09180 ENOG4105E35 Dipicolinate synthase subunit A HT135_RS09185 ENOG4108S0H Dipicolinic acid synthetase, b subunit HT135_RS09190 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HT135_RS09200 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HT135_RS09210 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HT135_RS09220 ENOG4105CNU cell division protein FtsK HT135_RS09225 ENOG4105FDP GntR family transcriptional regulator HT135_RS09245 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HT135_RS09250 ENOG4105XZV Protein of unknown function (DUF3243) HT135_RS09265 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HT135_RS09270 ENOG4105CEV competence damage-inducible protein HT135_RS09280 ENOG4108A04 Beta-lactamase HT135_RS09285 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HT135_RS09290 ENOG4105D48 metallophosphoesterase HT135_RS09295 ENOG4105MCT stage V sporulation protein S HT135_RS09305 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HT135_RS09310 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HT135_RS09325 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HT135_RS09330 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HT135_RS09365 ENOG4105K7W phage-related replication protein HT135_RS09395 ENOG4105IIP Membrane HT135_RS09400 ENOG4105W1N transcriptional regulator HT135_RS09405 ENOG4108151 Beta-lactamase domain protein HT135_RS09410 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HT135_RS09420 ENOG4107QKG PfaD family HT135_RS09425 ENOG41062T2 Acyl carrier protein HT135_RS09430 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase HT135_RS09435 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HT135_RS09440 ENOG4108MGH Enoyl-CoA hydratase HT135_RS09445 ENOG4108KQ6 Enoyl-CoA hydratase HT135_RS09450 ENOG4105C0W non-ribosomal peptide synthetase HT135_RS09455 ENOG4107SQU synthase HT135_RS09465 ENOG4105C0W non-ribosomal peptide synthetase HT135_RS09475 ENOG4106A3M Cytochrome p-450 HT135_RS09485 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_RS09490 ENOG4105K7W phage-related replication protein HT135_RS09495 ENOG4108X3M OsmC Ohr family protein HT135_RS09520 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HT135_RS09525 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HT135_RS09545 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HT135_RS09550 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_RS09555 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_RS09560 ENOG4105U6W MutT NUDIX family protein HT135_RS09565 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HT135_RS09570 ENOG4106F1P AAA ATPase, central domain protein HT135_RS09575 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HT135_RS09580 ENOG4105CXI aluminum resistance protein HT135_RS09585 ENOG4105KV4 Transcriptional regulator HT135_RS09590 ENOG4105C5F glutamine synthetase HT135_RS09595 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HT135_RS09605 ENOG4106BHF HT135_RS09610 ENOG410780I phosphoprotein phosphatase activity HT135_RS09620 ENOG4108U7W acetyltransferase HT135_RS09655 ENOG4108RZ2 Glycoside hydrolase family 16 HT135_RS09695 ENOG4107T94 Endo-14-beta-xylanase HT135_RS09720 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HT135_RS09725 ENOG41073R8 VanW family HT135_RS09730 ENOG4105NX3 Membrane HT135_RS09735 ENOG4105VMP Transcriptional regulator HT135_RS09745 ENOG4108RAV Conserved protein HT135_RS09790 ENOG4105FVX HT135_RS09800 ENOG4105K7W phage-related replication protein HT135_RS09820 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HT135_RS09830 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HT135_RS09840 ENOG4108SVB resolvase HT135_RS09845 ENOG4105VPS UPF0291 protein HT135_RS09850 ENOG4105CV1 Transketolase (EC 2.2.1.1) HT135_RS09870 ENOG4107QIV Cytochrome c biogenesis protein HT135_RS09895 ENOG4107DZX Small, acid-soluble spore protein P HT135_RS09905 ENOG4108I0Z Aconitate hydratase HT135_RS09910 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HT135_RS09925 ENOG41067CD Small, acid-soluble spore protein Tlp HT135_RS09935 ENOG4105MI2 HT135_RS09940 ENOG4105W8X HesB YadR YfhF-family protein HT135_RS09945 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HT135_RS09950 ENOG4105K4P CoA-binding domain protein HT135_RS09955 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HT135_RS09975 ENOG4107QWR cellulase (EC 3.2.1.4) HT135_RS09990 ENOG4108MYR Secreted protein HT135_RS09995 ENOG4107SYN Glycosyl hydrolases family 43 HT135_RS10010 ENOG4107T5V SNARE associated Golgi HT135_RS10020 ENOG4107QX3 carboxylase HT135_RS10025 ENOG4105E39 Enoyl-CoA hydratase HT135_RS10030 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HT135_RS10035 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HT135_RS10040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HT135_RS10045 ENOG4105CEY Amp-dependent synthetase and ligase HT135_RS10050 ENOG4105C1G acyl-Coa dehydrogenase HT135_RS10060 ENOG4105F32 YngK protein HT135_RS10065 ENOG4106U2H Protein of unknown function (DUF1360) HT135_RS10075 ENOG4105CEY Amp-dependent synthetase and ligase HT135_RS10080 ENOG4105C0W non-ribosomal peptide synthetase HT135_RS10090 ENOG4105C0W non-ribosomal peptide synthetase HT135_RS10095 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HT135_RS10100 ENOG4108N2V aldose 1-epimerase HT135_RS10105 ENOG4107QJQ Mate efflux family protein HT135_RS10130 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HT135_RS10135 ENOG4105SKE transcriptional Regulator LysR family HT135_RS10140 ENOG4105CB2 alcohol dehydrogenase HT135_RS10145 ENOG4105BZ8 glutamate synthase HT135_RS10150 ENOG4105CBC glutamate synthase HT135_RS10155 ENOG4105C5Q Transcriptional regulator HT135_RS10160 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HT135_RS10190 ENOG4108UB7 HT135_RS10195 ENOG41068WN HT135_RS10210 ENOG4105CJ1 ABC, transporter HT135_RS10220 ENOG4105IE8 Alpha-ketoglutarate permease HT135_RS10225 ENOG4107U6E carbohydrate kinase FGGY HT135_RS10230 ENOG4108M3J Dehydrogenase HT135_RS10235 ENOG4108J2R molybdopterin oxidoreductase HT135_RS10245 ENOG4105CIB oxidoreductase Domain protein HT135_RS10250 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HT135_RS10255 ENOG4105ETE Transcriptional regulator (LacI family HT135_RS10260 ENOG4108YQE rare lipoprotein a HT135_RS10265 ENOG4105XPP Protein of unknown function (DUF1275) HT135_RS10270 ENOG4108NR7 pectate lyase HT135_RS10275 ENOG4105CHR reductase HT135_RS10310 ENOG4105C54 Major Facilitator superfamily HT135_RS10315 ENOG4107Y9E nuclease HT135_RS10330 ENOG4105CMG Carbohydrate kinase HT135_RS10345 ENOG4105DSG hydrolase family 43 HT135_RS10350 ENOG4105CT4 transporter HT135_RS10365 ENOG4108M1A Chitin-binding protein HT135_RS10470 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HT135_RS10495 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HT135_RS10510 ENOG4108Z7R Chaperone CsaA HT135_RS10515 ENOG4105FTV AraC Family Transcriptional Regulator HT135_RS10520 ENOG4108HJF gCN5-related N-acetyltransferase HT135_RS10530 ENOG4108W8B Beta-lactamase domain protein HT135_RS10540 ENOG4105D29 Helix-turn-helix type 11 domain protein HT135_RS10550 ENOG4105KTU Transcriptional regulator, arsr family HT135_RS10560 ENOG4108SJC Membrane HT135_RS10580 ENOG4105ECK Fatty Acid Desaturase HT135_RS10585 ENOG4108ZGX Histidine kinase HT135_RS10590 ENOG4108S01 response regulator HT135_RS10600 ENOG41069ER domain protein HT135_RS10605 ENOG4105C9U ATP-dependent DNA helicase RecQ HT135_RS10615 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HT135_RS10620 ENOG4105SCY DNAK suppressor HT135_RS10635 ENOG4105C26 Dehydrogenase HT135_RS10640 ENOG4105EWU Squalene--hopene cyclase HT135_RS10645 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HT135_RS10650 ENOG4105C8J )-transporter HT135_RS10655 ENOG4105C09 Bile acid HT135_RS10660 ENOG4105C7S Dehydrogenase HT135_RS10670 ENOG4107T89 von Willebrand factor, type A HT135_RS10675 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HT135_RS10685 ENOG4105K4H Nlp p60 protein HT135_RS10690 ENOG41087PP glycosyltransferase MGT family HT135_RS10700 ENOG4107QMU Mate efflux family protein HT135_RS10705 ENOG4106SCS STAS domain HT135_RS10725 ENOG4105FR1 rard protein HT135_RS10745 ENOG41090U3 tautomerase HT135_RS10765 ENOG4105FBA Phospholipase Carboxylesterase HT135_RS10780 ENOG4105E1V na solute symporter HT135_RS10800 ENOG4108VXD carboxy-peptidase HT135_RS10805 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HT135_RS10815 ENOG4106Z5R HT135_RS10820 ENOG410841Q phosphoesterase PA-phosphatase related protein HT135_RS10850 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HT135_RS10855 ENOG4108TSC N-acetyltransferase HT135_RS10860 ENOG4107S4Y M20 DapE family protein YgeY HT135_RS10875 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT135_RS10910 ENOG4107T32 3-phytase (EC 3.1.3.8) HT135_RS10925 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HT135_RS11010 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HT135_RS11015 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HT135_RS11040 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HT135_RS11050 ENOG4106ITI Glutaredoxin HT135_RS11055 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_RS11060 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_RS11070 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_RS11075 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HT135_RS11170 ENOG4105DVF Cytosine-specific methyltransferase HT135_RS11215 ENOG4106J9J DNA polymerase HT135_RS11225 ENOG4106IVX HT135_RS11230 ENOG4106PTB DnaB-like helicase C terminal domain HT135_RS11240 ENOG41088HM HT135_RS11245 ENOG4106YR8 HT135_RS11270 ENOG4105K7W phage-related replication protein HT135_RS11290 ENOG4108RAV Conserved protein HT135_RS11295 ENOG4108J9Q DNA ligase HT135_RS11410 ENOG4107D0N HT135_RS11465 ENOG4107NTZ HT135_RS11510 ENOG4108NE4 HT135_RS11540 ENOG41067QW Transcriptional regulator HT135_RS11550 ENOG4105ZUG HT135_RS11555 ENOG4105K70 DNA-binding protein HT135_RS11665 ENOG41068G1 HT135_RS11705 ENOG4105E4C Lytic transglycosylase catalytic HT135_RS11730 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HT135_RS11750 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HT135_RS11770 ENOG4106ANW SMI1_KNR4 HT135_RS11775 ENOG4106BHF HT135_RS11790 ENOG4107Y9E nuclease HT135_RS11815 ENOG4105C5E polysaccharide biosynthesis protein HT135_RS11820 ENOG4105E0X reductase HT135_RS11825 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HT135_RS11845 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HT135_RS11850 ENOG41090WU lipolytic protein G-D-S-L family HT135_RS11855 ENOG4108KF3 Electron transport protein SCO1 SenC HT135_RS11865 ENOG4105C7B Threonine dehydratase HT135_RS11875 ENOG4108UT2 hemolysin iii HT135_RS11885 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HT135_RS11905 ENOG4107YX5 Pfam:DUF548 HT135_RS11910 ENOG4108Y6J UPF0403 protein HT135_RS11915 ENOG4105C01 Dihydroxy-acid dehydratase HT135_RS11930 ENOG4108V06 Glutathione peroxidase HT135_RS11935 ENOG4105CVG Homoserine O-transsuccinylase HT135_RS11975 ENOG41081VK Ribonuclease HT135_RS12000 ENOG410890F Dynamin family HT135_RS12015 ENOG41065KQ synthase HT135_RS12020 ENOG4105C2W permease HT135_RS12025 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HT135_RS12030 ENOG4105CTD carboxy-peptidase HT135_RS12035 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HT135_RS12040 ENOG4108UHU Aldolase HT135_RS12045 ENOG4105D7K pfkb domain protein HT135_RS12050 ENOG4108M60 Transcriptional regulator HT135_RS12060 ENOG4105CHR reductase HT135_RS12065 ENOG4105DVT helicase HT135_RS12080 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HT135_RS12090 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HT135_RS12095 ENOG4108UKS UPF0398 protein HT135_RS12110 ENOG4107X2U Inherit from COG: Exonuclease-like protein HT135_RS12115 ENOG4108I5C dEAD DEAH box helicase HT135_RS12165 ENOG4105BZ4 penicillin-binding protein HT135_RS12175 ENOG4105CSM endonuclease III HT135_RS12185 ENOG4105C5S asparaginyl-tRNA synthetase HT135_RS12190 ENOG4105CHM Aminotransferase HT135_RS12200 ENOG4105YAC HT135_RS12205 ENOG4105DVT helicase HT135_RS12210 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HT135_RS12215 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HT135_RS12220 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HT135_RS12225 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HT135_RS12230 ENOG4105DJ0 Poly(A) Polymerase HT135_RS12235 ENOG4105CPK Glycosyl transferase (Group 1 HT135_RS12240 ENOG4105FJR Lmbe family HT135_RS12245 ENOG4108Z5K methylglyoxal synthase HT135_RS12250 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HT135_RS12255 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HT135_RS12260 ENOG4108JYZ YitT family HT135_RS12280 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HT135_RS12300 ENOG41068YB TPR repeat-containing protein HT135_RS12305 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HT135_RS12315 ENOG4105CIH Imidazole acetol-phosphate transaminase HT135_RS12325 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HT135_RS12330 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HT135_RS12340 ENOG4108I0Q anthranilate phosphoribosyltransferase HT135_RS12345 ENOG4105CRQ synthase (Component I) HT135_RS12350 ENOG4105KHN chorismate mutase HT135_RS12355 ENOG4105D49 3-dehydroquinate synthase HT135_RS12360 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HT135_RS12365 ENOG4105BZU Histidine kinase HT135_RS12370 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HT135_RS12375 ENOG4105EAH synthase HT135_RS12380 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HT135_RS12385 ENOG4105XXQ heptaprenyl diphosphate synthase component I HT135_RS12395 ENOG4105EUJ GTP cyclohydrolase i HT135_RS12400 ENOG4105K70 DNA-binding protein HT135_RS12405 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HT135_RS12420 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HT135_RS12425 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HT135_RS12430 ENOG41065D1 HT135_RS12435 ENOG4105S2F HT135_RS12450 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HT135_RS12455 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HT135_RS12460 ENOG4105CAT Cytidine monophosphate kinase HT135_RS12475 ENOG4105MSI germination protein ypeb HT135_RS12485 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HT135_RS12490 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HT135_RS12505 ENOG4107RGJ metallophosphoesterase HT135_RS12520 ENOG4105I7S Abortive infection protein HT135_RS12525 ENOG4105C9U ATP-dependent DNA helicase RecQ HT135_RS12530 ENOG4105T7X HT135_RS12540 ENOG4108SAX Membrane HT135_RS12545 ENOG4108JQ1 Dehydrogenase HT135_RS12550 ENOG4105FF2 Type I DHQase HT135_RS12565 ENOG4105BZU Histidine kinase HT135_RS12570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT135_RS12575 ENOG4105CRE cytochrome C HT135_RS12580 ENOG4107TWT Cytochrome c biogenesis protein HT135_RS12590 ENOG4105FE9 pseudouridine synthase HT135_RS12600 ENOG4108JIC nucleoside recognition domain protein HT135_RS12605 ENOG4105DZ1 carboxypeptidase HT135_RS12615 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HT135_RS12620 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HT135_RS12640 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HT135_RS12645 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HT135_RS12650 ENOG4108R6K riboflavin synthase, subunit alpha HT135_RS12655 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HT135_RS12665 ENOG4105C3F Signal peptidase i HT135_RS12670 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) HT135_RS12675 ENOG4107ZE5 PPIases accelerate the folding of proteins HT135_RS12680 ENOG4105PTM secreted protein HT135_RS12685 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HT135_RS12695 ENOG4105G6R Stage v sporulation protein ae HT135_RS12705 ENOG4105CZ3 stage V sporulation protein ad HT135_RS12710 ENOG41090VF Stage v sporulation protein ac HT135_RS12725 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_RS12730 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HT135_RS12735 ENOG41082AN stage II sporulation protein HT135_RS12740 ENOG4105DZ1 carboxypeptidase HT135_RS12745 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HT135_RS12750 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HT135_RS12755 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HT135_RS12765 ENOG4105I3K Ferric uptake regulator, Fur family HT135_RS12770 ENOG4105MZ9 stage II sporulation protein m HT135_RS12785 ENOG4105DFD Na H antiporter HT135_RS12790 ENOG4108IJ0 Aspartate ammonia-lyase HT135_RS12795 ENOG4105HDK L-asparaginase HT135_RS12800 ENOG4108IMY Transcriptional regulator HT135_RS12810 ENOG4108YZ4 nudix hydrolase HT135_RS12820 ENOG4105CPC Aldo Keto reductase HT135_RS12840 ENOG4106HZJ HT135_RS12845 ENOG4105RHY Pfam:UPF0157 HT135_RS12850 ENOG4105KAC Antibiotic biosynthesis monooxygenase HT135_RS12855 ENOG4108XET gCN5-related N-acetyltransferase HT135_RS12865 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HT135_RS12875 ENOG4105E5W Transporter HT135_RS12885 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_RS12900 ENOG4108IXY short-chain dehydrogenase reductase HT135_RS12905 ENOG41069FQ Metallo-beta-lactamase superfamily HT135_RS12910 ENOG4105II7 pyrroline-5-carboxylate reductase HT135_RS12920 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HT135_RS12930 ENOG410861F 50S ribosomal protein L33 HT135_RS12935 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HT135_RS12940 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HT135_RS12950 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HT135_RS12955 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HT135_RS12965 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HT135_RS12975 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HT135_RS12980 ENOG4108HNZ carboxyl transferase HT135_RS12985 ENOG4108ZVT methylmalonyl-coA epimerase HT135_RS12995 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HT135_RS13000 ENOG4108QEG Membrane HT135_RS13005 ENOG4105CDA abc transporter atp-binding protein HT135_RS13010 ENOG4105E5Q amino acid AbC transporter HT135_RS13015 ENOG4108HW3 (ABC) transporter HT135_RS13020 ENOG4108Y6J UPF0403 protein HT135_RS13025 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HT135_RS13040 ENOG4105C7S Dehydrogenase HT135_RS13045 ENOG4105CPP Dehydrogenase, E1 component HT135_RS13060 ENOG4105CKM Branched-chain carboxylic acid kinase HT135_RS13065 ENOG4107RDP Dehydrogenase HT135_RS13075 ENOG4108JUB Transcriptional regulator HT135_RS13080 ENOG4106CCJ Protein of unknown function (DUF2627) HT135_RS13085 ENOG4105CR4 methylisocitrate lyase HT135_RS13090 ENOG4105DXD 2-methylcitrate dehydratase HT135_RS13100 ENOG4105C1G acyl-Coa dehydrogenase HT135_RS13105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HT135_RS13115 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HT135_RS13120 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HT135_RS13135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HT135_RS13140 ENOG4107QQR Sporulation HT135_RS13145 ENOG4105S1Z Stage IV sporulation protein B HT135_RS13150 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HT135_RS13155 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HT135_RS13160 ENOG4105DX0 Hemolysin A HT135_RS13170 ENOG4105CTB Polyprenyl synthetase HT135_RS13175 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HT135_RS13180 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HT135_RS13185 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HT135_RS13190 ENOG4105M7K Involved in the transcription termination process (By similarity) HT135_RS13195 ENOG4108ZSR alkaline shock protein HT135_RS13200 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HT135_RS13220 ENOG410644B Stage III sporulation protein af HT135_RS13230 ENOG4105KQ4 Stage iii sporulation protein ad HT135_RS13235 ENOG4108CQH stage III sporulation protein AC HT135_RS13240 ENOG4105KR5 Stage iii sporulation protein HT135_RS13245 ENOG4105CD2 stage iii sporulation protein aa HT135_RS13255 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HT135_RS13260 ENOG4105DC7 peptidase M24 HT135_RS13265 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HT135_RS13275 ENOG4105CBJ Metal-dependent enzyme HT135_RS13290 ENOG4105KST dependent repressor HT135_RS13295 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HT135_RS13300 ENOG4105WZW rhodanese family HT135_RS13305 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HT135_RS13310 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HT135_RS13315 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HT135_RS13320 ENOG4105C0D helicase HT135_RS13335 ENOG4108IMY Transcriptional regulator HT135_RS13345 ENOG4105VFR signal peptidase HT135_RS13400 ENOG41080XP Cbs domain HT135_RS13410 ENOG4105C37 (CBS) domain HT135_RS13435 ENOG4105C5X domain protein HT135_RS13460 ENOG4105E0M Sulfatase HT135_RS13475 ENOG4107ZXI Rhomboid family HT135_RS13485 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HT135_RS13510 ENOG41068DG YceG-like family HT135_RS13515 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HT135_RS13520 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HT135_RS13525 ENOG4105E2Z phosphate ABC transporter (Permease HT135_RS13530 ENOG4105C8U phosphate abc transporter HT135_RS13535 ENOG4105CVA phosphate HT135_RS13540 ENOG4107RF6 penicillin-binding protein HT135_RS13550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HT135_RS13555 ENOG4105SXS Protein of unknown function (DUF456) HT135_RS13570 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HT135_RS13575 ENOG41063Y9 HT135_RS13580 ENOG4108U5J '-nucleotidase HT135_RS13585 ENOG4105N80 Ferric uptake regulator, Fur family HT135_RS13590 ENOG4108JYZ YitT family HT135_RS13595 ENOG41069ZM Protein of unknown function (DUF2624) HT135_RS13600 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HT135_RS13615 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HT135_RS13620 ENOG4105EGD dinuclear metal center protein, YbgI family HT135_RS13635 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_RS13640 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HT135_RS13645 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 HT135_RS13650 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HT135_RS13660 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HT135_RS13665 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HT135_RS13670 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HT135_RS13680 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HT135_RS13685 ENOG4105KG3 cytidine deaminase HT135_RS13690 ENOG4107YR5 Diacylglycerol kinase HT135_RS13695 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HT135_RS13700 ENOG4105CTJ Metal Dependent Phosphohydrolase HT135_RS13705 ENOG4105C9A Phoh family HT135_RS13710 ENOG4105EI1 sporulation protein yqfd HT135_RS13715 ENOG41068P3 sporulation protein YqfC HT135_RS13725 ENOG4105DI5 UPF0365 protein HT135_RS13730 ENOG4105F7J membrane-bound serine protease HT135_RS13735 ENOG4105KTH gatB Yqey HT135_RS13750 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HT135_RS13755 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HT135_RS13760 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HT135_RS13770 ENOG4105CFG Acts as a chaperone (By similarity) HT135_RS13775 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HT135_RS13780 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HT135_RS13785 ENOG4105CSA Coproporphyrinogen iii oxidase HT135_RS13790 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HT135_RS13800 ENOG4108ZRV stage ii sporulation protein p HT135_RS13805 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HT135_RS13810 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HT135_RS13815 ENOG4105TQK DNA polymerase iii, delta' subunit HT135_RS13830 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HT135_RS13835 ENOG4108UK2 deaminase HT135_RS13840 ENOG4105KQC Competence protein HT135_RS13850 ENOG4108D32 Methyltransferase HT135_RS13860 ENOG4108WF2 Metal Dependent Phosphohydrolase HT135_RS13865 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HT135_RS13870 ENOG410812S Rna-binding protein HT135_RS13875 ENOG4105E2X shikimate dehydrogenase HT135_RS13880 ENOG4105CQW ribosome biogenesis GTPase YqeH HT135_RS13885 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HT135_RS13900 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HT135_RS13905 ENOG41080BT SNARE associated Golgi HT135_RS13920 ENOG4105WFK nuclease HT135_RS13925 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_RS13955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HT135_RS13970 ENOG4107XZQ multidrug resistance protein HT135_RS13980 ENOG4105H3G oxidoreductase HT135_RS13985 ENOG4105PGM cation diffusion facilitator family transporter HT135_RS14020 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HT135_RS14085 ENOG4105QBX endodeoxyribonuclease RusA HT135_RS14105 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HT135_RS14125 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HT135_RS14130 ENOG4105KVH Transcriptional regulator HT135_RS14135 ENOG4108DBC nitroreductase HT135_RS14155 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HT135_RS14165 ENOG41067XF inhibitor HT135_RS14195 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HT135_RS14210 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HT135_RS14215 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT135_RS14220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT135_RS14230 ENOG4108JQ7 (ABC) transporter HT135_RS14240 ENOG4108MEK Metal-binding protein YodA HT135_RS14250 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HT135_RS14255 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HT135_RS14270 ENOG4105KRI phosphocarrier protein (HPr HT135_RS14280 ENOG4105VUF Transcriptional regulator HT135_RS14285 ENOG4105DQ4 alcohol dehydrogenase HT135_RS14290 ENOG4108Z0Z intracellular protease Pfpi family HT135_RS14295 ENOG4108HKT sucrose-6-phosphate hydrolase HT135_RS14300 ENOG4105F3R pts system mannose fructose sorbose family iid HT135_RS14305 ENOG4105ETZ PTS System HT135_RS14310 ENOG4108IQ3 PTS system HT135_RS14315 ENOG4105YHU PTS system HT135_RS14320 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HT135_RS14325 ENOG4105C85 amino acid HT135_RS14330 ENOG4105N14 lysine exporter protein LysE YggA HT135_RS14335 ENOG4108NGU Transcriptional regulator HT135_RS14340 ENOG4105JVQ RNA Polymerase HT135_RS14345 ENOG4108P49 AntiSigma factor HT135_RS14350 ENOG4105EXC Acyl-transferase HT135_RS14355 ENOG4105WDR HT135_RS14360 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HT135_RS14365 ENOG41082JN Transcriptional regulator HT135_RS14385 ENOG4105TMB Formate nitrite transporter HT135_RS14390 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HT135_RS14395 ENOG4108JB9 formate dehydrogenase HT135_RS14410 ENOG4105C28 cystathionine HT135_RS14425 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HT135_RS14440 ENOG4107XRG penicillin-binding protein HT135_RS14445 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HT135_RS14450 ENOG4105DBI uridine monophosphokinase HT135_RS14455 ENOG4105CFP Peptidase U32 HT135_RS14460 ENOG4105XYU peptidase (U32 family) HT135_RS14470 ENOG4105HHA aminodeoxychorismate lyase HT135_RS14475 ENOG4105VPH UPF0473 protein HT135_RS14480 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HT135_RS14485 ENOG4105VBH UPF0297 protein HT135_RS14490 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HT135_RS14495 ENOG4105C02 permease HT135_RS14500 ENOG4105CDA abc transporter atp-binding protein HT135_RS14505 ENOG4105CT1 (ABC) transporter HT135_RS14510 ENOG4105EAD ABC transporter HT135_RS14515 ENOG4105DRP amino acid AbC transporter HT135_RS14525 ENOG41060CR HT135_RS14535 ENOG4105C7H Helicase, RecD TraA family HT135_RS14545 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HT135_RS14550 ENOG4105C3J Cysteine desulfurase HT135_RS14560 ENOG4105D1H recombination factor protein RarA HT135_RS14565 ENOG4105CUZ uba thif-type nad fad binding protein HT135_RS14575 ENOG4105C9M aspartyl-trna synthetase HT135_RS14580 ENOG4105CUT histidyl-tRNA synthetase HT135_RS14590 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HT135_RS14595 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HT135_RS14600 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HT135_RS14605 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HT135_RS14610 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HT135_RS14615 ENOG41067VP Protein of unknown function (DUF1049) HT135_RS14620 ENOG4105NCW Trka-c domain protein HT135_RS14625 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HT135_RS14635 ENOG4105CKP Polysaccharide Biosynthesis Protein HT135_RS14640 ENOG4108QG2 Membrane HT135_RS14645 ENOG4105NAP HT135_RS14650 ENOG4105VIE preprotein translocase, subunit YajC HT135_RS14655 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HT135_RS14660 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HT135_RS14665 ENOG41061AI Protein of unknown function (DUF2905) HT135_RS14670 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HT135_RS14675 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HT135_RS14685 ENOG4105IE8 Alpha-ketoglutarate permease HT135_RS14690 ENOG4105CK5 oxidoreductase HT135_RS14710 ENOG4105BZG amino acid carrier protein HT135_RS14715 ENOG4105CDY transcriptional regulatory protein HT135_RS14725 ENOG4106678 morphogenetic protein associated with SpoVID HT135_RS14730 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HT135_RS14735 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HT135_RS14740 ENOG4108IYU L-aspartate oxidase HT135_RS14755 ENOG4105CQC Prephenate dehydratase HT135_RS14760 ENOG41090I5 UPF0735 ACT domain-containing protein HT135_RS14765 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HT135_RS14780 ENOG4105K46 50S ribosomal protein l27 HT135_RS14785 ENOG4105X36 (ribosomal) protein HT135_RS14790 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HT135_RS14805 ENOG4107QMS site-determining protein HT135_RS14810 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HT135_RS14815 ENOG4105YHC Rod shape-determining protein MreD HT135_RS14825 ENOG4105DFF Rod shape-determining protein mreb HT135_RS14830 ENOG4105W5Q DNA repair protein (RadC HT135_RS14835 ENOG4108Z03 MAF-like protein HT135_RS14845 ENOG4106A3R peptidase HT135_RS14850 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HT135_RS14855 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HT135_RS14865 ENOG4106AR7 Spore coat protein HT135_RS14870 ENOG41068KH stage VI sporulation protein D HT135_RS14875 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HT135_RS14880 ENOG4105D52 delta-aminolevulinic acid dehydratase HT135_RS14890 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HT135_RS14900 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HT135_RS14910 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HT135_RS14915 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HT135_RS14920 ENOG4108IUQ atp-dependent protease HT135_RS14925 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HT135_RS14930 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HT135_RS14940 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HT135_RS14945 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HT135_RS14950 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HT135_RS14955 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HT135_RS14960 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HT135_RS14965 ENOG4108ZP8 Acetolactate synthase small subunit HT135_RS14970 ENOG4105C7K acetolactate synthase HT135_RS14980 ENOG4105I4A GCN5-related N-acetyltransferase HT135_RS14985 ENOG4107KM7 Heat induced stress protein YflT HT135_RS14995 ENOG4105M59 Phosphodiesterase, mj0936 family HT135_RS15000 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HT135_RS15005 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HT135_RS15010 ENOG4108XJQ germination protein HT135_RS15015 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HT135_RS15020 ENOG41067TZ transcriptional regulator, MarR family HT135_RS15025 ENOG4105PFC Transcriptional regulator HT135_RS15035 ENOG4105E33 succinate dehydrogenase HT135_RS15045 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HT135_RS15055 ENOG4105CFH Aspartokinase HT135_RS15065 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HT135_RS15070 ENOG4105K63 Thioredoxin HT135_RS15075 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HT135_RS15080 ENOG4105C10 Electron transfer flavoprotein HT135_RS15085 ENOG4105BZJ Electron transfer flavoprotein HT135_RS15090 ENOG41060WC Enoyl-CoA hydratase HT135_RS15095 ENOG4107Z3H Transcriptional regulator, TetR family HT135_RS15100 ENOG4105CEY Amp-dependent synthetase and ligase HT135_RS15110 ENOG4105C98 muts2 protein HT135_RS15115 ENOG4105DCG PHP domain protein HT135_RS15130 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HT135_RS15135 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HT135_RS15140 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HT135_RS15150 ENOG4108RWN rrna methyltransferase HT135_RS15155 ENOG41067MF small acid-soluble spore protein HT135_RS15165 ENOG4105CQB FAD linked oxidase domain protein HT135_RS15170 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HT135_RS15195 ENOG4105K7K Transcriptional regulator HT135_RS15200 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HT135_RS15205 ENOG4105DRS transport system, permease HT135_RS15220 ENOG4108MDK Dehydrogenase HT135_RS15230 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HT135_RS15235 ENOG4105EF1 ribulokinase HT135_RS15245 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HT135_RS15250 ENOG4105CN9 Peptidase m42 family protein HT135_RS15260 ENOG410696E Membrane HT135_RS15265 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HT135_RS15270 ENOG4105VJV 50s ribosomal protein L35 HT135_RS15275 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HT135_RS15285 ENOG41067MG lrgb family HT135_RS15295 ENOG4105DY9 regulatoR HT135_RS15300 ENOG4108HRK Histidine kinase HT135_RS15310 ENOG4105C22 threonyL-tRNA synthetase HT135_RS15315 ENOG4108TDW sporulation protein YtxC HT135_RS15335 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HT135_RS15340 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HT135_RS15345 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HT135_RS15350 ENOG4105KVH Transcriptional regulator HT135_RS15355 ENOG4105F27 Major Facilitator HT135_RS15360 ENOG4105CV8 reductase HT135_RS15365 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HT135_RS15375 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HT135_RS15380 ENOG4105C2M dna polymerase I HT135_RS15385 ENOG4105BZU Histidine kinase HT135_RS15390 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HT135_RS15395 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HT135_RS15400 ENOG4108HMX isocitrate dehydrogenase (NADP) HT135_RS15405 ENOG4105BZN citrate synthase HT135_RS15415 ENOG4108REF Sporulation integral membrane protein ytvi HT135_RS15420 ENOG4105FS0 cytoplasmic membrane protein HT135_RS15425 ENOG4105CA9 Pyruvate kinase HT135_RS15430 ENOG4105CTQ phosphohexokinase HT135_RS15440 ENOG4108IEY Carboxyl transferase domain HT135_RS15445 ENOG4105C6K Malic enzyme HT135_RS15450 ENOG4105C0B DNA polymerase III (alpha subunit) HT135_RS15455 ENOG4105VV2 HT135_RS15465 ENOG4106EVM HT135_RS15470 ENOG4105SFS phosphoesterase RecJ domain protein HT135_RS15485 ENOG410635A Membrane HT135_RS15490 ENOG4105CH2 amidohydrolase HT135_RS15510 ENOG4105DEN Luciferase family HT135_RS15515 ENOG4105CDA abc transporter atp-binding protein HT135_RS15540 ENOG4108XSB acetyltransferase, (GNAT) family HT135_RS15545 ENOG4108KSA LysR family transcriptional regulator HT135_RS15550 ENOG4105E8R UPF0173 metal-dependent hydrolase HT135_RS15560 ENOG4105CH7 arginosuccinase HT135_RS15565 ENOG4105CDH Citrulline--aspartate ligase HT135_RS15570 ENOG4105EPU Molybdenum cofactor synthesis domain protein HT135_RS15575 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HT135_RS15585 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HT135_RS15590 ENOG4105KBJ sporulation protein ytfj HT135_RS15600 ENOG4105VK3 rdd domain containing protein HT135_RS15605 ENOG4105D07 Signal peptide peptidase, SppA HT135_RS15610 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HT135_RS15615 ENOG4105EFZ amidohydrolase HT135_RS15620 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HT135_RS15655 ENOG4105U5Y Transcriptional regulator HT135_RS15665 ENOG4105BZU Histidine kinase HT135_RS15670 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HT135_RS15675 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HT135_RS15685 ENOG4105F1V Acetoin utilization protein HT135_RS15690 ENOG4105W87 Cbs domain HT135_RS15695 ENOG4105DGU Histone deacetylase HT135_RS15700 ENOG4105ER2 Ompa motb domain protein HT135_RS15705 ENOG4107R0U MotA TolQ exbB proton channel HT135_RS15710 ENOG4105ETE Transcriptional regulator (LacI family HT135_RS15715 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HT135_RS15735 ENOG4105DFU Cell wall formation (By similarity) HT135_RS15745 ENOG4108VDD TRNA binding domain protein HT135_RS15765 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HT135_RS15780 ENOG4105C6K Malic enzyme HT135_RS15785 ENOG4105C8F Beta-lactamase domain protein HT135_RS15790 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HT135_RS15800 ENOG4108V15 phosphotransferase enzyme family HT135_RS15805 ENOG4108IUM Glycogen debranching enzyme HT135_RS15820 ENOG4107F58 2'-5' rna ligase HT135_RS15825 ENOG4105C6T cysteine synthase HT135_RS15830 ENOG4107QSE Dipeptidase HT135_RS15835 ENOG4105C7N Xanthine uracil vitamin C permease HT135_RS15850 ENOG4105YW5 deoR family transcriptional regulator HT135_RS15865 ENOG4105CBX hi0933 family HT135_RS15870 ENOG4105C94 Transporter HT135_RS15880 ENOG4105MU9 integral membrane protein HT135_RS15885 ENOG4105DDC Oxidoreductase domain protein HT135_RS15895 ENOG4105F5H Glycosyl Hydrolase Family 88 HT135_RS15905 ENOG41075H3 AraC family transcriptional regulator HT135_RS15915 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HT135_RS15925 ENOG4106A3M Cytochrome p-450 HT135_RS15930 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HT135_RS15940 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HT135_RS15945 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT135_RS15955 ENOG4105NTD Inherit from COG: Hydrolase HT135_RS15985 ENOG41085GJ domain protein HT135_RS15990 ENOG4105C8T Leucyl-tRNA synthetase HT135_RS16000 ENOG4105BZU Histidine kinase HT135_RS16005 ENOG410605W Major Facilitator HT135_RS16010 ENOG4106UBQ HT135_RS16020 ENOG4105C19 ABC transporter HT135_RS16025 ENOG4105EWM Histidine kinase HT135_RS16035 ENOG4107R34 abc transporter permease protein HT135_RS16040 ENOG4105C19 ABC transporter HT135_RS16055 ENOG4105DVE abc transporter atp-binding protein HT135_RS16060 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HT135_RS16075 ENOG4105N5T Radical SAM Protein HT135_RS16090 ENOG4105E8V Alpha Beta Hydrolase Fold protein HT135_RS16095 ENOG4108Z0R Transferase HT135_RS16100 ENOG4105C85 amino acid HT135_RS16105 ENOG4105CAQ asparagine synthetase HT135_RS16110 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HT135_RS16115 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HT135_RS16130 ENOG4105D2X ABC transporter substrate-binding protein HT135_RS16140 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HT135_RS16155 ENOG4108RMU ferritin dps family protein HT135_RS16170 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HT135_RS16175 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HT135_RS16180 ENOG4108V2W Carbonate dehydratase HT135_RS16205 ENOG4105CC5 ABC transporter HT135_RS16210 ENOG4105CC5 ABC transporter HT135_RS16215 ENOG4105DIK (ABC) transporter HT135_RS16220 ENOG4105DSE periplasmic solute binding protein HT135_RS16225 ENOG4105DTQ mandelate racemase muconate lactonizing HT135_RS16230 ENOG4105CEY Amp-dependent synthetase and ligase HT135_RS16235 ENOG4108IPT Naphthoate synthase HT135_RS16240 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HT135_RS16245 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HT135_RS16250 ENOG4105E4F Isochorismate synthase HT135_RS16270 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HT135_RS16280 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HT135_RS16410 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HT135_RS16415 ENOG4105VRR gCN5-related N-acetyltransferase HT135_RS16420 ENOG4105DZ6 Band 7 protein HT135_RS16430 ENOG4106DF1 HT135_RS16435 ENOG4108VNY MOSC domain protein HT135_RS16440 ENOG4108JB8 alcohol dehydrogenase HT135_RS16450 ENOG4105TRT Transcriptional regulator HT135_RS16465 ENOG4105CZN Potassium uptake protein HT135_RS16470 ENOG4107I77 yiaA/B two helix domain HT135_RS16475 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HT135_RS16495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HT135_RS16505 ENOG4105EE0 oxidoreductase HT135_RS16510 ENOG4105DKG l-rhamnose isomerase HT135_RS16515 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HT135_RS16520 ENOG4105DET Rhamnulokinase HT135_RS16525 ENOG4105E98 transcriptional regulator DeoR family HT135_RS16535 ENOG4105C8Q Methyl-accepting chemotaxis HT135_RS16540 ENOG4105C8Q Methyl-accepting chemotaxis HT135_RS16545 ENOG4105C8Q Methyl-accepting chemotaxis HT135_RS16550 ENOG4105C8Q Methyl-accepting chemotaxis HT135_RS16565 ENOG4105EA8 2-Nitropropane dioxygenase HT135_RS16570 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HT135_RS16580 ENOG4105C37 (CBS) domain HT135_RS16595 ENOG4107PBV potassium channel HT135_RS16600 ENOG4107PBV potassium channel HT135_RS16615 ENOG4107QYV phosphohexose isomerase HT135_RS16625 ENOG4107QW4 alcohol dehydrogenase HT135_RS16630 ENOG4105WG9 Conserved Protein HT135_RS16640 ENOG4105CHM Aminotransferase HT135_RS16645 ENOG4108ZB6 transcriptional regulator AsnC family HT135_RS16650 ENOG4108MUZ hydrolase HT135_RS16660 ENOG4105C87 Aminotransferase class I and II HT135_RS16665 ENOG4108HGU Histidine kinase HT135_RS16670 ENOG4105Y38 Kinase-associated protein B HT135_RS16685 ENOG4105BZ4 penicillin-binding protein HT135_RS16690 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HT135_RS16705 ENOG4108MRH transcriptional regulatory protein HT135_RS16710 ENOG4105DIH basic membrane HT135_RS16715 ENOG4108JQ9 ABC transporter HT135_RS16720 ENOG4105UIB (ABC) transporter HT135_RS16740 ENOG4105D65 subunit l HT135_RS16745 ENOG4105HC0 Na H antiporter HT135_RS16750 ENOG4108ZE9 Monovalent cation H antiporter subunit C HT135_RS16755 ENOG4108JPZ Monovalent cation H antiporter subunit D HT135_RS16760 ENOG4105SC1 monovalent cation H antiporter subunit E HT135_RS16770 ENOG4105KJM monovalent cation h antiporter subunit g HT135_RS16775 ENOG4105KA0 thioesterase Superfamily protein HT135_RS16810 ENOG4105D58 Diguanylate phosphodiesterase HT135_RS16815 ENOG4105DAP Nicotinate phosphoribosyltransferase HT135_RS16840 ENOG4105C02 permease HT135_RS16855 ENOG410904N short-chain dehydrogenase reductase HT135_RS16890 ENOG4108K8K Transcriptional regulator HT135_RS16895 ENOG4105DCF alanine dehydrogenase HT135_RS16905 ENOG4105WQT MbtH domain protein HT135_RS16910 ENOG4105CEY Amp-dependent synthetase and ligase HT135_RS16915 ENOG4105WQI isochorismatase HT135_RS16920 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HT135_RS16925 ENOG4105E4F Isochorismate synthase HT135_RS16930 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HT135_RS16935 ENOG4105NIV Esterase HT135_RS16955 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HT135_RS16965 ENOG41069ER domain protein HT135_RS16980 ENOG4105CEP NADH dehydrogenase HT135_RS16985 ENOG4105CAY ferredoxin--nadp reductase HT135_RS17000 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HT135_RS17015 ENOG4105ZKE UPF0349 protein HT135_RS17030 ENOG41083MR nifu domain-containing protein HT135_RS17035 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HT135_RS17040 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HT135_RS17045 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HT135_RS17050 ENOG4105D6E homoserine dehydrogenase HT135_RS17060 ENOG4108W5N phosphatidylglycerophosphatase a HT135_RS17065 ENOG4105D4U had-superfamily hydrolase, subfamily iia HT135_RS17075 ENOG4105MMD transcriptional regulator HT135_RS17080 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HT135_RS17085 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HT135_RS17090 ENOG4105FAA peptidase M23 HT135_RS17095 ENOG4108YTE sporulation protein YunB HT135_RS17100 ENOG4105KZD Domain of unknown function (DUF1805) HT135_RS17105 ENOG4107R8B 5'-nucleotidase HT135_RS17115 ENOG4105I3N Conserved Protein HT135_RS17125 ENOG4105CD3 dihydroorotase HT135_RS17130 ENOG4105G9B Transcriptional regulator HT135_RS17145 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HT135_RS17150 ENOG4105VT2 5-hydroxyisourate hydrolase HT135_RS17160 ENOG4107YV9 domain protein HT135_RS17165 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HT135_RS17180 ENOG4105XRQ Xanthine dehydrogenase accessory factor HT135_RS17185 ENOG4105C5R Aminotransferase HT135_RS17195 ENOG4108K8S endonuclease I HT135_RS17200 ENOG4108IJ9 (ABC) transporter HT135_RS17205 ENOG4105FDP GntR family transcriptional regulator HT135_RS17210 ENOG4108KPW sugar kinase HT135_RS17215 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HT135_RS17220 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HT135_RS17225 ENOG4105XN3 extracellular solute-binding protein family 1 HT135_RS17230 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HT135_RS17235 ENOG4105PKS Excinuclease abc c subunit domain protein HT135_RS17240 ENOG4107VFR oxidoreductase HT135_RS17260 ENOG4105DIW FeS assembly protein SUFB HT135_RS17265 ENOG4108UNV SUF system FeS assembly protein, NifU family HT135_RS17270 ENOG4105C9B Cysteine desulfurase HT135_RS17275 ENOG4105JRK feS assembly protein SufD HT135_RS17280 ENOG4105C3K feS assembly ATPase SufC HT135_RS17295 ENOG4105D01 (LipO)protein HT135_RS17300 ENOG4108UMI ABC transporter, permease HT135_RS17305 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HT135_RS17330 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HT135_RS17335 ENOG41080E8 Transcriptional regulator, Spx MgsR family HT135_RS17340 ENOG4105C1G acyl-Coa dehydrogenase HT135_RS17345 ENOG4105CHU acetyl-coa acetyltransferase HT135_RS17375 ENOG41067TZ transcriptional regulator, MarR family HT135_RS17380 ENOG4105C0R drug resistance transporter emrb qaca subfamily HT135_RS17385 ENOG4105MDS 4-oxalocrotonate tautomerase HT135_RS17395 ENOG4105EGI Transcriptional regulator HT135_RS17405 ENOG4105E0A ABC, transporter HT135_RS17420 ENOG4105E1F short-chain dehydrogenase reductase HT135_RS17425 ENOG4105HUF DNA protection during starvation protein HT135_RS17430 ENOG4105C0H protease HT135_RS17440 ENOG4105F3H Histidine kinase HT135_RS17450 ENOG41067SE Tetr family transcriptional regulator HT135_RS17455 ENOG4105C9Q fumarate hydratase class II HT135_RS17480 ENOG4105WH1 Two component transcriptional regulator luxr family HT135_RS17485 ENOG4105ENE Histidine kinase HT135_RS17500 ENOG41087YS Phage shock protein A HT135_RS17515 ENOG4108WBT adenosyltransferase HT135_RS17520 ENOG4105E0A ABC, transporter HT135_RS17525 ENOG4105EHG Permease protein HT135_RS17530 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HT135_RS17535 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HT135_RS17540 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HT135_RS17550 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HT135_RS17560 ENOG4106DF4 Sigma-70, region 4 HT135_RS17570 ENOG4105F0F Oxalate decarboxylase HT135_RS17580 ENOG4107RBB ABC transporter, permease HT135_RS17585 ENOG4105C19 ABC transporter HT135_RS17590 ENOG4108WMK Efflux transporter RND family MFP subunit HT135_RS17595 ENOG4105E0A ABC, transporter HT135_RS17600 ENOG4105EHG Permease protein HT135_RS17605 ENOG4105DQ5 transport system permease protein HT135_RS17615 ENOG4105D5Q Arginine ornithine antiporter HT135_RS17625 ENOG4107K5X Membrane-bound metal-dependent hydrolase HT135_RS17630 ENOG4107QZ2 Sulfatase HT135_RS17635 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HT135_RS17640 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HT135_RS17645 ENOG4105E0C molybdate abc transporter HT135_RS17660 ENOG4105EEQ Na H antiporter HT135_RS17665 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HT135_RS17670 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HT135_RS17675 ENOG4105EEM helicase HT135_RS17685 ENOG4105EN6 Membrane HT135_RS17695 ENOG4107ZQN disulfide bond HT135_RS17700 ENOG4105C59 p-type ATPase HT135_RS17705 ENOG4105C59 p-type ATPase HT135_RS17710 ENOG410681U heavy metal transport detoxification protein HT135_RS17715 ENOG4105VPX protein, conserved in bacteria HT135_RS17720 ENOG4105D9R oxidoreductase HT135_RS17725 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HT135_RS17730 ENOG4105ME7 Membrane HT135_RS17735 ENOG4105DRR Transcriptional regulator, GntR family HT135_RS17740 ENOG4108UZ3 Transporter HT135_RS17745 ENOG4105RXJ HT135_RS17750 ENOG4105KPY Small multidrug resistance protein HT135_RS17755 ENOG4105KBX Transcriptional regulator, TetR family HT135_RS17760 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HT135_RS17770 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HT135_RS17775 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HT135_RS17785 ENOG4105XZU Preprotein translocase, subunit SecG HT135_RS17810 ENOG4105KVH Transcriptional regulator HT135_RS17815 ENOG4105C8Q Methyl-accepting chemotaxis HT135_RS17820 ENOG4105R40 Glycine betaine carnitine choline HT135_RS17825 ENOG4108HQR Glycine betaine HT135_RS17830 ENOG4105E90 ABC transporter HT135_RS17835 ENOG4108IJ8 ABC transporter HT135_RS17840 ENOG4107HG4 Transcriptional regulator HT135_RS17850 ENOG4105H5S HT135_RS17865 ENOG41082BM Transcriptional regulator, arsr family HT135_RS17870 ENOG4105R40 Glycine betaine carnitine choline HT135_RS17875 ENOG4108HQR Glycine betaine HT135_RS17880 ENOG4105E90 ABC transporter HT135_RS17885 ENOG4108IJ8 ABC transporter HT135_RS17890 ENOG4107HG4 Transcriptional regulator HT135_RS17895 ENOG4108QCI YvbH-like oligomerisation region HT135_RS17905 ENOG4105T65 Membrane-associated protein HT135_RS17910 ENOG4108W0I acetyltransferase HT135_RS17925 ENOG4105FJR Lmbe family HT135_RS17945 ENOG4108IAJ Nad-dependent epimerase dehydratase HT135_RS17950 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HT135_RS17955 ENOG4107QQG Dehydrogenase HT135_RS17960 ENOG4105IIU Aminopeptidase HT135_RS17965 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HT135_RS17970 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HT135_RS17975 ENOG4105CP7 Triose-phosphate isomerase HT135_RS17980 ENOG4105BZA Phosphoglycerate kinase HT135_RS17985 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HT135_RS18000 ENOG4105CMD Transcriptional regulator, GntR family HT135_RS18005 ENOG4105DEN Luciferase family HT135_RS18010 ENOG4105GZI Transcriptional regulator HT135_RS18015 ENOG4107RT3 EamA-like transporter family HT135_RS18025 ENOG4105VRS hydrolase family 18 HT135_RS18030 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HT135_RS18035 ENOG4107QR9 Iron-sulfur cluster binding protein HT135_RS18040 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HT135_RS18050 ENOG4105BZU Histidine kinase HT135_RS18055 ENOG4105KCT ABC transporter HT135_RS18060 ENOG4108M15 ABC transporter HT135_RS18065 ENOG4107R6F Alpha Beta Hydrolase Fold protein HT135_RS18070 ENOG4108MJI response regulator HT135_RS18085 ENOG4105EG2 ABC transporter, permease HT135_RS18095 ENOG4107FKK extracellular solute-binding protein family 1 HT135_RS18105 ENOG4105JXH GntR family transcriptional regulator HT135_RS18110 ENOG4105DAA L-lactate HT135_RS18115 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_RS18125 ENOG4108ZPC Polysaccharide pyruvyl transferase HT135_RS18130 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HT135_RS18135 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HT135_RS18140 ENOG4105D3Q Sugar transferase HT135_RS18150 ENOG4105K64 Glycosyl transferase, family 2 HT135_RS18160 ENOG4107QRS glycosyltransferase group 2 family protein HT135_RS18165 ENOG41068W6 Capsular polysaccharide biosynthesis protein HT135_RS18170 ENOG4108KMV Glycosyl transferase (Group 1 HT135_RS18175 ENOG4105K64 Glycosyl transferase, family 2 HT135_RS18180 ENOG4108PQP glycosyl transferase group 1 HT135_RS18190 ENOG4108QV3 biosynthesis protein HT135_RS18195 ENOG4105HTX biosynthesis protein HT135_RS18205 ENOG4105EBR Carboxylesterase HT135_RS18215 ENOG4105PY6 Phenolic acid decarboxylase HT135_RS18220 ENOG4105NI3 Protein of unknown function (DUF3237) HT135_RS18230 ENOG4105FQP Beta-lactamase HT135_RS18240 ENOG4108UXE Protein tyrosine phosphatase HT135_RS18245 ENOG4107R5R arsenical pump membrane protein HT135_RS18250 ENOG41082YX Transcriptional regulator, arsr family HT135_RS18255 ENOG4105EDQ levansucrase EC 2.4.1.10 HT135_RS18260 ENOG4108HKT sucrose-6-phosphate hydrolase HT135_RS18265 ENOG4107QTZ amino acid HT135_RS18295 ENOG4105DNP FAD linked oxidase domain protein HT135_RS18300 ENOG4105IRW patatin-like phospholipase family protein HT135_RS18310 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HT135_RS18315 ENOG4108URH decarboxylase HT135_RS18320 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HT135_RS18325 ENOG4105CHH sulfate transporter HT135_RS18330 ENOG4108V2W Carbonate dehydratase HT135_RS18335 ENOG4105C5I Dehydrogenase HT135_RS18345 ENOG4105C19 ABC transporter HT135_RS18350 ENOG4105EWM Histidine kinase HT135_RS18360 ENOG4107A6P HT135_RS18365 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HT135_RS18370 ENOG4105KRI phosphocarrier protein (HPr HT135_RS18375 ENOG4105CIE May be required for sporulation (By similarity) HT135_RS18380 ENOG4105CHW UPF0052 protein HT135_RS18385 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HT135_RS18390 ENOG4108Z4K mutator MutT protein HT135_RS18395 ENOG4105C3M thioredoxin reductase HT135_RS18410 ENOG4105BZ1 (ABC) transporter HT135_RS18420 ENOG4106FGC HT135_RS18430 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HT135_RS18435 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HT135_RS18440 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HT135_RS18445 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HT135_RS18450 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HT135_RS18455 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HT135_RS18460 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HT135_RS18465 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HT135_RS18475 ENOG4108E16 pectate lyase HT135_RS18480 ENOG4108S4C acetyltransferase HT135_RS18485 ENOG4107XGZ Hydrolase HT135_RS18490 ENOG4105HKU nucleoside recognition domain-containing protein HT135_RS18495 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HT135_RS18500 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HT135_RS18505 ENOG4105CE4 GlcNAc 6-P deacetylase HT135_RS18510 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HT135_RS18520 ENOG41088CQ domain protein HT135_RS18540 ENOG41086DT Membrane protein of unknown function HT135_RS18545 ENOG41067S9 phage shock protein C, PspC HT135_RS18550 ENOG4108PY7 HT135_RS18565 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HT135_RS18570 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HT135_RS18585 ENOG4105MKU Transcriptional regulator HT135_RS18605 ENOG4105CN1 protease HT135_RS18610 ENOG4105CRP Part of the ABC transporter FtsEX involved in HT135_RS18615 ENOG4105CAK Cell division ATP-binding protein ftsE HT135_RS18640 ENOG4105MS2 ribosomal subunit Interface protein HT135_RS18655 ENOG4105MQ3 flagellar protein FliS HT135_RS18660 ENOG4107RT6 flagellar hook-associated HT135_RS18665 ENOG41083S7 flagellar protein FlaG HT135_RS18670 ENOG4105I03 Flagellin HT135_RS18675 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HT135_RS18680 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HT135_RS18685 ENOG4105MKD HT135_RS18690 ENOG4105DTJ flagellar hook-associated protein HT135_RS18695 ENOG4105E1Q flagellar hook-associated protein HT135_RS18710 ENOG4105RU3 HT135_RS18715 ENOG41081UC Inherit from COG: Competence protein HT135_RS18735 ENOG4105WH1 Two component transcriptional regulator luxr family HT135_RS18740 ENOG4105BZU Histidine kinase HT135_RS18745 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HT135_RS18750 ENOG4108KGH TRANSCRIPTIONal HT135_RS18755 ENOG4105ESV Glycosyl transferase, family 4 HT135_RS18760 ENOG4107EF8 Glycosyl transferase (Group 1 HT135_RS18775 ENOG4105QZI O-Antigen Polymerase HT135_RS18780 ENOG4105C6Y Udp-glucose 6-dehydrogenase HT135_RS18785 ENOG4107RA4 Glycosyl transferase (Group 1 HT135_RS18790 ENOG4105PSV Polysaccharide Biosynthesis Protein HT135_RS18795 ENOG4105D3Q Sugar transferase HT135_RS18800 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HT135_RS18805 ENOG4105JFG SpoIID LytB domain protein HT135_RS18820 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HT135_RS18835 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HT135_RS18840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HT135_RS18845 ENOG4105EY8 ABC transporter HT135_RS18870 ENOG41088M2 Glycosyl transferase family 2 HT135_RS18920 ENOG4105DG6 mannose-6-phosphate isomerase HT135_RS18935 ENOG4108NHD germination protein HT135_RS18940 ENOG4105C54 Major Facilitator superfamily HT135_RS18945 ENOG4108KGH TRANSCRIPTIONal HT135_RS18950 ENOG4105J7I hydrolase HT135_RS18955 ENOG4105K4H Nlp p60 protein HT135_RS18965 ENOG4105PNM synthesis protein HT135_RS18975 ENOG4105N98 Capsule biosynthesis protein capB HT135_RS18980 ENOG4105ETE Transcriptional regulator (LacI family HT135_RS18985 ENOG4108RVA ribokinase HT135_RS18990 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HT135_RS18995 ENOG4105C2J ABC transporter HT135_RS19000 ENOG4105CNN ABC, transporter HT135_RS19005 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HT135_RS19020 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HT135_RS19025 ENOG4107FQX Alpha-acetolactate decarboxylase HT135_RS19035 ENOG4107RSM transcriptional regulator HT135_RS19050 ENOG4106UIA HT135_RS19050 ENOG4106UIA HT135_RS19065 ENOG4107XC4 flavin reductase domain protein, FMN-binding HT135_RS19070 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HT135_RS19085 ENOG4105UP7 3-epimerase HT135_RS19095 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HT135_RS19105 ENOG4105CAH Chromate HT135_RS19110 ENOG4105FGV Chromate HT135_RS19120 ENOG4108WS4 fmn reductase HT135_RS19125 ENOG4107V2S Transcriptional regulator HT135_RS19130 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HT135_RS19185 ENOG4105C6Y Udp-glucose 6-dehydrogenase HT135_RS19190 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HT135_RS19195 ENOG4107YJ4 chain length determinant protein HT135_RS19200 ENOG4105HTX biosynthesis protein HT135_RS19210 ENOG4105KBK Zinc finger, swim domain protein HT135_RS19215 ENOG4105C0D helicase HT135_RS19220 ENOG410667J hydrolase HT135_RS19225 ENOG4105E98 transcriptional regulator DeoR family HT135_RS19230 ENOG4105Z8H single-stranded DNA-binding protein HT135_RS19245 ENOG4108HWY Beta-lactamase HT135_RS19250 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HT135_RS19255 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HT135_RS19265 ENOG4105CGA flagellar basal-body rod protein FlgG HT135_RS19275 ENOG4105DFF Rod shape-determining protein mreb HT135_RS19280 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HT135_RS19290 ENOG4107MII Sugar-specific transcriptional regulator TrmB HT135_RS19295 ENOG4105CZM Major Facilitator HT135_RS19300 ENOG4108M26 parallel beta-helix repeat protein HT135_RS19305 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HT135_RS19310 ENOG41080V3 Major Facilitator superfamily HT135_RS19315 ENOG4105D3W isochorismatase HT135_RS19320 ENOG4107P26 HT135_RS19325 ENOG4105BZU Histidine kinase HT135_RS19335 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HT135_RS19345 ENOG4105FRN stage II sporulation protein HT135_RS19350 ENOG4107TCE N-acetyltransferase HT135_RS19365 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HT135_RS19370 ENOG4106BRK HT135_RS19375 ENOG4108RYK Nad-dependent epimerase dehydratase HT135_RS19380 ENOG4108Z40 Transcriptional regulator HT135_RS19385 ENOG4105CQM Urea amidohydrolase subunit alpha HT135_RS19390 ENOG4105KI2 Urea amidohydrolase subunit beta HT135_RS19395 ENOG4108YZ9 Urea amidohydrolase subunit gamma HT135_RS19400 ENOG4108IV0 ABC, transporter HT135_RS19405 ENOG4105C0Z ABC transporter HT135_RS19415 ENOG4105C32 Amino acid ABC transporter (Permease) HT135_RS19420 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HT135_RS19445 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HT135_RS19455 ENOG4108TF4 von Willebrand factor, type A HT135_RS19465 ENOG4105JFG SpoIID LytB domain protein HT135_RS19470 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HT135_RS19480 ENOG4106778 Protein of unknown function (DUF1146) HT135_RS19490 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HT135_RS19495 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HT135_RS19500 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HT135_RS19505 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HT135_RS19525 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) HT135_RS19535 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HT135_RS19540 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HT135_RS19545 ENOG4108UIC UPF0340 protein HT135_RS19550 ENOG4108YZG isomerase HT135_RS19555 ENOG4107WAU Protein tyrosine phosphatase HT135_RS19560 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HT135_RS19565 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HT135_RS19575 ENOG4108ZXQ stage ii sporulation protein r HT135_RS19590 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HT135_RS19595 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HT135_RS19600 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HT135_RS19610 ENOG4107TT2 Auxin Efflux Carrier HT135_RS19615 ENOG4105C6K Malic enzyme HT135_RS19620 ENOG4107104 thymidine kinase HT135_RS19630 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HT135_RS19640 ENOG4105CBT Fructose-1,6-bisphosphatase HT135_RS19645 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HT135_RS19650 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway HT135_RS19655 ENOG4105D2N Aldolase HT135_RS19660 ENOG410812K response regulator receiver protein HT135_RS19670 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HT135_RS19680 ENOG4105C1G acyl-Coa dehydrogenase HT135_RS19685 ENOG4105DF6 Fe-S oxidoreductase HT135_RS19695 ENOG4105E5J UV damage endonuclease HT135_RS19705 ENOG4105NAE bifunctional deaminase-reductase domain protein HT135_RS19710 ENOG4105BZ1 (ABC) transporter HT135_RS19715 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HT135_RS19730 ENOG4105R3A Nitrate reductase HT135_RS19735 ENOG4108IUE nitrate reductase beta subunit HT135_RS19755 ENOG4107V6Q Cyclic nucleotide-binding domain HT135_RS19765 ENOG4105C75 arginyL-tRNA synthetase HT135_RS19770 ENOG410684U Domain of unknown function (DUF1934) HT135_RS19780 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HT135_RS19825 ENOG4107JM4 Tetratricopeptide repeat HT135_RS19835 ENOG4105CYW agmatinase HT135_RS19840 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HT135_RS19845 ENOG4105BZ4 penicillin-binding protein HT135_RS19855 ENOG4108XFG YwhD family HT135_RS19860 ENOG4108Z4T Peptidase M50 HT135_RS19865 ENOG41069HH 4-oxalocrotonate tautomerase HT135_RS19870 ENOG41067TZ transcriptional regulator, MarR family HT135_RS19875 ENOG4105C22 threonyL-tRNA synthetase HT135_RS19880 ENOG4105C57 major facilitator superfamily HT135_RS19885 ENOG41062ES Transcriptional regulator HT135_RS19895 ENOG4105DCI Phosphohydrolase HT135_RS19905 ENOG4108VCI transcription factor, rsfa family HT135_RS19910 ENOG4108RNG Permease of the drug metabolite transporter HT135_RS19915 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HT135_RS19920 ENOG4105DUM transcriptional regulator, lysR family HT135_RS19925 ENOG4108IJ2 phosphate acetyltransferase HT135_RS19940 ENOG4105CHM Aminotransferase HT135_RS19950 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase HT135_RS19955 ENOG4105CHR reductase HT135_RS19960 ENOG4106CHD Bacilysin biosynthesis protein bacB HT135_RS19965 ENOG41061WN bacilysin biosynthesis protein HT135_RS19970 ENOG4105FCW Major Facilitator superfamily HT135_RS19990 ENOG4105C26 Dehydrogenase HT135_RS19995 ENOG4105D82 Glutamate dehydrogenase HT135_RS20005 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HT135_RS20010 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HT135_RS20015 ENOG4105C1B dTDP-glucose 4-6-dehydratase HT135_RS20020 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HT135_RS20025 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG HT135_RS20030 ENOG4107TY6 Acylneuraminate cytidylyltransferase HT135_RS20040 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HT135_RS20045 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HT135_RS20080 ENOG4105C26 Dehydrogenase HT135_RS20085 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HT135_RS20090 ENOG4108RJ9 Glycosyl transferase, family 2 HT135_RS20110 ENOG4105DWF phosphomethylpyrimidine kinase HT135_RS20125 ENOG4105C5Y PTS System HT135_RS20130 ENOG4108QTI )-transporter HT135_RS20145 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_RS20150 ENOG4105DEN Luciferase family HT135_RS20155 ENOG4108DBC nitroreductase HT135_RS20180 ENOG4105BZ9 Cytochrome C oxidase, subunit I HT135_RS20185 ENOG4105E2S oxidase) subunit II HT135_RS20190 ENOG4107BMA Transglycosylase associated protein HT135_RS20200 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HT135_RS20205 ENOG4105WH5 Teichoic acid glycosylation protein HT135_RS20230 ENOG4107ZXU DSBA oxidoreductase HT135_RS20235 ENOG4105DBE peroxidase HT135_RS20240 ENOG410650H (LipO)protein HT135_RS20245 ENOG4107SJW iron permease, FTR1 HT135_RS20250 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HT135_RS20260 ENOG4105CMU LysR family (Transcriptional regulator HT135_RS20265 ENOG4105VAW lrga family HT135_RS20270 ENOG41067MG lrgb family HT135_RS20275 ENOG4105D8G Major Facilitator superfamily HT135_RS20285 ENOG4105DR4 Methyltransferase HT135_RS20295 ENOG4108YV3 Protein of unknown function (DUF2711) HT135_RS20300 ENOG4105CK1 PTS System HT135_RS20305 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_RS20320 ENOG4105X1N Glycosyl transferase family 8 HT135_RS20330 ENOG4105GVJ transcriptional regulator HT135_RS20335 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HT135_RS20340 ENOG4105IIU Aminopeptidase HT135_RS20350 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HT135_RS20360 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HT135_RS20365 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HT135_RS20375 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HT135_RS20380 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HT135_RS20385 ENOG4105CM2 brancheD-chain amino acid aminotransferase HT135_RS20390 ENOG4105F8D glycoside hydrolase family 4 HT135_RS20395 ENOG4105VCP PTS System HT135_RS20400 ENOG4105CK1 PTS System HT135_RS20405 ENOG4105VZJ PTS System HT135_RS20410 ENOG4105EMD TRANSCRIPTIONal HT135_RS20420 ENOG4108VX5 3-methyladenine DNA glycosylase HT135_RS20425 ENOG4105CH6 catalase HT135_RS20440 ENOG4105DA5 (ABC) transporter HT135_RS20445 ENOG41069JR HT135_RS20465 ENOG4105ETS cytosine purines uracil thiamine allantoin HT135_RS20470 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HT135_RS20475 ENOG4108JJ8 (ABC) transporter HT135_RS20480 ENOG4108JJ9 ABC, transporter HT135_RS20485 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HT135_RS20490 ENOG4105C4M (Ubiquinol oxidase) subunit I HT135_RS20495 ENOG4105D2K citrate carrier protein HT135_RS20510 ENOG4107BJW polysaccharide deacetylase HT135_RS20530 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HT135_RS20540 ENOG4105CMR udp-glucose 4-epimerase HT135_RS20550 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HT135_RS20575 ENOG4108JUB Transcriptional regulator HT135_RS20580 ENOG4105DTD Dehydrogenase HT135_RS20585 ENOG4108IIH CoA-transferase subunit B HT135_RS20590 ENOG4105D6N CoA-transferase, subunit a HT135_RS20595 ENOG4105CY2 Citrate transporter HT135_RS20600 ENOG4105DHI Methyltransferase HT135_RS20620 ENOG4105CH6 catalase HT135_RS20625 ENOG4105D4T Citrate transporter HT135_RS20635 ENOG4105CS2 ec 3.2.1.21 HT135_RS20640 ENOG4105C5Y PTS System HT135_RS20645 ENOG4105CID antiterminator HT135_RS20655 ENOG4105DEU major facilitator superfamily HT135_RS20660 ENOG4105C1J atp-dependent rna helicase HT135_RS20665 ENOG4107TDE lipolytic protein G-D-S-L family HT135_RS20725 ENOG4107YZX Universal stress protein HT135_RS20730 ENOG4105CS2 ec 3.2.1.21 HT135_RS20735 ENOG4105C5Y PTS System HT135_RS20755 ENOG4107EV6 Inherit from COG: YD repeat protein HT135_RS20790 ENOG4106Z5D Glycoside Hydrolase Family 43 HT135_RS20805 ENOG4105C84 Histidine ammonia-lyase HT135_RS20810 ENOG4105CGP Urocanate hydratase HT135_RS20815 ENOG4105CI2 imidazolone-5-propionate hydrolase HT135_RS20820 ENOG4107W25 arginase agmatinase formiminoglutamase HT135_RS20830 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HT135_RS20835 ENOG4105D9N nucleoside HT135_RS20845 ENOG4107RHR regulatoR HT135_RS20850 ENOG4108TM9 integral membrane protein HT135_RS20855 ENOG4105ENY Ethanolamine utilization protein eutH HT135_RS20860 ENOG4108PGP mmge prpd family protein HT135_RS20875 ENOG4108HW4 amino acid AbC transporter HT135_RS20880 ENOG4105EAB amino acid AbC transporter HT135_RS20900 ENOG4107QHE Choloylglycine hydrolase HT135_RS20905 ENOG410667J hydrolase HT135_RS20935 ENOG4108V5C ABC transporter HT135_RS20965 ENOG4105D2N Aldolase HT135_RS20970 ENOG4105WZ4 isomerase HT135_RS20975 ENOG4105F0H myo-inositol catabolism protein HT135_RS20980 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HT135_RS20990 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HT135_RS20995 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HT135_RS21000 ENOG4105D7K pfkb domain protein HT135_RS21010 ENOG4105C26 Dehydrogenase HT135_RS21020 ENOG4105CPC Aldo Keto reductase HT135_RS21045 ENOG4107QNK )-transporter HT135_RS21050 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HT135_RS21060 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HT135_RS21065 ENOG4105ST3 Transcriptional regulator HT135_RS21070 ENOG4105C26 Dehydrogenase HT135_RS21075 ENOG41085PJ rdd domain containing protein HT135_RS21080 ENOG4108ITS PQQ enzyme repeat HT135_RS21090 ENOG41085PJ rdd domain containing protein HT135_RS21105 ENOG4105J7D transcriptional regulator HT135_RS21110 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HT135_RS21115 ENOG41061AU MarR family Transcriptional regulator HT135_RS21125 ENOG41067MG lrgb family HT135_RS21155 ENOG4105BZW Glycerate kinase HT135_RS21160 ENOG4105G3Z GntR family transcriptional regulator HT135_RS21165 ENOG4105CMG Carbohydrate kinase HT135_RS21170 ENOG4105C6Z Gluconate HT135_RS21175 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HT135_RS21180 ENOG4105D3R alkyl hydroperoxide reductase HT135_RS21185 ENOG4108JU3 Alkyl hydroperoxide reductase HT135_RS21190 ENOG4105CS2 ec 3.2.1.21 HT135_RS21200 ENOG4108S3Y transcriptional regulator HT135_RS21210 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HT135_RS21245 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HT135_RS21260 ENOG4105E2A Dehydrogenase HT135_RS21280 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HT135_RS21285 ENOG4105WQG acetyltransferase HT135_RS21290 ENOG410780I phosphoprotein phosphatase activity HT135_RS21300 ENOG41066UZ arginase EC 3.5.3.1 HT135_RS21305 ENOG4108IQI permease HT135_RS21310 ENOG4105C8Y Acetylornithine aminotransferase HT135_RS21315 ENOG4108JUB Transcriptional regulator HT135_RS21320 ENOG4105C0H protease HT135_RS21325 ENOG4105Q2H domain protein HT135_RS21340 ENOG4105BZU Histidine kinase HT135_RS21345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT135_RS21370 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HT135_RS21375 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_RS21380 ENOG4105CDU Replicative dna helicase HT135_RS21400 ENOG4105DJ2 Major Facilitator Superfamily HT135_RS21405 ENOG4105EDW glycosyl transferase, family 39 HT135_RS21410 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HT135_RS21415 ENOG4105BZR domain protein HT135_RS21420 ENOG4108XMW Membrane HT135_RS21435 ENOG4105KVH Transcriptional regulator HT135_RS21440 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HT135_RS21465 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HT135_RS21475 ENOG4105D94 Major Facilitator Superfamily HT135_RS21480 ENOG4107RSM transcriptional regulator HT135_RS21485 ENOG41082BV acetyltransferase HT135_RS21490 ENOG41081I9 integral membrane protein HT135_RS21495 ENOG4107V2S Transcriptional regulator HT135_RS21500 ENOG4108VP3 Lysine exporter protein (LysE YggA) HT135_RS21505 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_RS21520 ENOG4108ZHR arsR family transcriptional regulator HT135_RS21525 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HT135_RS21535 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HT135_RS21550 ENOG4108IXY short-chain dehydrogenase reductase HT135_RS21560 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HT135_RS21570 ENOG4105M4P Tetr family transcriptional regulator HT135_RS21590 ENOG4108Z5V transcriptional regulator, merr family HT135_RS21595 ENOG4108UQV Membrane HT135_RS21600 ENOG41086D8 Transcriptional regulator HT135_RS21620 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HT135_RS21625 ENOG4105C7Z Conserved Protein HT135_RS21645 ENOG4105MSY salicylate hydroxylase HT135_RS21650 ENOG41068WC Domain of unknown function (DUF955) HT135_RS21685 ENOG4105C7Z Conserved Protein HT135_RS21690 ENOG4107FCW Abortive infection protein HT135_RS21700 ENOG4108UW5 maltose o-acetyltransferase HT135_RS21705 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_RS21715 ENOG4105CGK Exodeoxyribonuclease III HT135_RS21720 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HT135_RS21725 ENOG4108UUM single-stranded DNA-binding protein HT135_RS21730 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HT135_RS21735 ENOG4105C3G gtp-binding protein HT135_RS21740 ENOG4108J2R molybdopterin oxidoreductase HT135_RS21745 ENOG4105VDK protein, conserved in bacteria HT135_RS21755 ENOG4108ZDA Sporulation protein YyaC HT135_RS21760 ENOG4105FA0 parb-like partition protein HT135_RS21765 ENOG4107QJE Chromosome Partitioning Protein HT135_RS21780 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HT135_RS21785 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HT135_RS21790 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HT135_RS21805 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)