locus-tag	class	description
I8N71_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I8N71_RS00010	COG0592	DNA-directed DNA polymerase activity
I8N71_RS00015	COG2501	S4 domain
I8N71_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I8N71_RS00030	COG0187	DNA topoisomerase II activity
I8N71_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8N71_RS00070	COG0517	IMP dehydrogenase activity
I8N71_RS00070	COG0516	GMP reductase activity
I8N71_RS00075	COG1686	Belongs to the peptidase S11 family
I8N71_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I8N71_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I8N71_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I8N71_RS00100	COG1428	Deoxynucleoside kinase
I8N71_RS00105	COG1428	Deoxynucleoside kinase
I8N71_RS00110	COG3858	chitin binding
I8N71_RS00110	COG1388	LysM domain
I8N71_RS00115	COG1335	isochorismatase
I8N71_RS00120	COG0590	tRNA wobble adenosine to inosine editing
I8N71_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I8N71_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I8N71_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I8N71_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I8N71_RS00190	COG3853	Toxic anion resistance protein (TelA)
I8N71_RS00195	COG1982	Orn Lys Arg decarboxylase major
I8N71_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I8N71_RS00205	COG3870	Protein conserved in bacteria
I8N71_RS00210	COG1728	Protein conserved in bacteria
I8N71_RS00215	COG0470	DNA polymerase III
I8N71_RS00220	COG1774	PSP1 C-terminal conserved region
I8N71_RS00225	COG4467	Involved in initiation control of chromosome replication
I8N71_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I8N71_RS00235	COG2827	Endonuclease containing a URI domain
I8N71_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I8N71_RS00245	COG2002	toxin-antitoxin pair type II binding
I8N71_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N71_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N71_RS00255	COG0084	hydrolase, TatD family'
I8N71_RS00260	COG3583	domain protein
I8N71_RS00260	COG3584	3D domain protein
I8N71_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I8N71_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I8N71_RS00280	COG4466	Protein conserved in bacteria
I8N71_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I8N71_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I8N71_RS00300	COG0251	oxidation-reduction process
I8N71_RS00305	COG2088	sporulation resulting in formation of a cellular spore
I8N71_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I8N71_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I8N71_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I8N71_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
I8N71_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I8N71_RS00340	COG2002	toxin-antitoxin pair type II binding
I8N71_RS00345	COG2244	polysaccharide biosynthetic process
I8N71_RS00350	COG3956	TIGRFAM MazG family protein
I8N71_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I8N71_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I8N71_RS00375	COG1098	S1 RNA binding domain
I8N71_RS00390	COG2208	phosphoserine phosphatase activity
I8N71_RS00395	COG2304	oxidoreductase activity
I8N71_RS00400	COG0515	serine threonine protein kinase
I8N71_RS00405	COG0037	tRNA processing
I8N71_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I8N71_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8N71_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I8N71_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I8N71_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8N71_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N71_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8N71_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
I8N71_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N71_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I8N71_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I8N71_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I8N71_RS00470	COG1396	sequence-specific DNA binding
I8N71_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8N71_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I8N71_RS00560	COG4463	regulation of RNA biosynthetic process
I8N71_RS00565	COG3880	PFAM UvrB UvrC protein
I8N71_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I8N71_RS00575	COG0542	response to heat
I8N71_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I8N71_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I8N71_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
I8N71_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I8N71_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I8N71_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I8N71_RS00610	COG1045	serine acetyltransferase
I8N71_RS00615	COG0215	cysteine-tRNA ligase activity
I8N71_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I8N71_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8N71_RS00630	COG3688	RNA-binding protein containing a PIN domain
I8N71_RS00635	COG1595	DNA-templated transcription, initiation
I8N71_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8N71_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
I8N71_RS00660	COG0081	regulation of translation
I8N71_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I8N71_RS00675	COG2813	Specifically methylates the guanine in position
I8N71_RS00680	COG0085	RNA polymerase activity
I8N71_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I8N71_RS00690	COG1358	cellular component organization or biogenesis
I8N71_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I8N71_RS00700	COG0049	tRNA binding
I8N71_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I8N71_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I8N71_RS00715	COG0596	Alpha beta hydrolase
I8N71_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I8N71_RS00730	COG0088	Forms part of the polypeptide exit tunnel
I8N71_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I8N71_RS00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I8N71_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I8N71_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I8N71_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I8N71_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I8N71_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I8N71_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I8N71_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I8N71_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I8N71_RS00820	COG0200	Binds to the 23S rRNA
I8N71_RS00825	COG0201	protein transport
I8N71_RS00830	COG0563	adenylate kinase activity
I8N71_RS00835	COG0024	Methionine aminopeptidase
I8N71_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I8N71_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I8N71_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I8N71_RS00865	COG0202	RNA polymerase activity
I8N71_RS00870	COG0203	ribosomal protein L17
I8N71_RS00875	COG1122	ATPase activity
I8N71_RS00880	COG1122	ATPase activity
I8N71_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I8N71_RS00890	COG0101	tRNA pseudouridine synthase activity
I8N71_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I8N71_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I8N71_RS00905	COG2226	methyltransferase
I8N71_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS00920	COG0489	protein tyrosine kinase activity
I8N71_RS00930	COG2194	sulfuric ester hydrolase activity
I8N71_RS00935	COG0726	polysaccharide deacetylase
I8N71_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
I8N71_RS01025	COG0385	Bile acid
I8N71_RS01030	COG2819	hydrolase of the alpha beta superfamily
I8N71_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N71_RS01050	COG2207	Transcriptional regulator
I8N71_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N71_RS01055	COG3876	Protein conserved in bacteria
I8N71_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
I8N71_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N71_RS01070	COG1263	PTS System
I8N71_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS01075	COG1737	Transcriptional regulator
I8N71_RS01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I8N71_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N71_RS01090	COG1683	Conserved Protein
I8N71_RS01120	COG1595	DNA-templated transcription, initiation
I8N71_RS01125	COG5662	AntiSigma factor
I8N71_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I8N71_RS01135	COG4856	YbbR-like protein
I8N71_RS01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8N71_RS01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I8N71_RS01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I8N71_RS01160	COG2169	Transcriptional regulator
I8N71_RS01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8N71_RS01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8N71_RS01175	COG3002	Belongs to the UPF0753 family
I8N71_RS01180	COG0288	reversible hydration of carbon dioxide
I8N71_RS01190	COG5609	conserved protein (DUF2294)
I8N71_RS01195	COG0640	Transcriptional regulator
I8N71_RS01200	COG2814	Major facilitator Superfamily
I8N71_RS01215	COG0535	radical SAM domain protein
I8N71_RS01220	COG1266	CAAX protease self-immunity
I8N71_RS01225	COG1131	(ABC) transporter
I8N71_RS01235	COG1413	lyase activity
I8N71_RS01240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS01245	COG0596	Alpha beta hydrolase
I8N71_RS01250	COG0745	RESPONSE REGULATOR receiver
I8N71_RS01255	COG0642	Histidine kinase
I8N71_RS01265	COG0515	serine threonine protein kinase
I8N71_RS01280	COG1113	amino acid transport
I8N71_RS01295	COG2602	Beta-lactamase
I8N71_RS01300	COG2124	cytochrome p450
I8N71_RS01310	COG0531	amino acid
I8N71_RS01315	COG0584	glycerophosphoryl diester phosphodiesterase
I8N71_RS01320	COG2271	Major facilitator Superfamily
I8N71_RS01330	COG0456	acetyltransferase
I8N71_RS01330	COG1846	Transcriptional regulator
I8N71_RS01335	COG2271	Major facilitator Superfamily
I8N71_RS01345	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS01350	COG0697	spore germination
I8N71_RS01355	COG2207	Transcriptional regulator
I8N71_RS01355	COG1917	Cupin 2, conserved barrel domain protein
I8N71_RS01360	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I8N71_RS01365	COG3591	Belongs to the peptidase S1B family
I8N71_RS01375	COG0596	Alpha beta hydrolase
I8N71_RS01380	COG1183	phosphatidylcholine synthase activity
I8N71_RS01385	COG0586	Pfam SNARE associated Golgi protein
I8N71_RS01390	COG0688	phosphatidylethanolamine metabolic process
I8N71_RS01400	COG2312	Erythromycin esterase
I8N71_RS01405	COG2207	Transcriptional regulator
I8N71_RS01410	COG1054	Belongs to the UPF0176 family
I8N71_RS01415	COG1301	dicarboxylic acid transport
I8N71_RS01420	COG2190	(PTS) system
I8N71_RS01420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS01420	COG1263	PTS System
I8N71_RS01425	COG0363	glucosamine-6-phosphate deaminase activity
I8N71_RS01430	COG2188	Transcriptional regulator
I8N71_RS01440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N71_RS01445	COG0833	amino acid
I8N71_RS01450	COG2040	homocysteine
I8N71_RS01455	COG1115	amino acid carrier protein
I8N71_RS01460	COG2066	Belongs to the glutaminase family
I8N71_RS01465	COG4191	Histidine kinase
I8N71_RS01470	COG0784	Response regulator, receiver
I8N71_RS01475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8N71_RS01480	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS01485	COG2271	Major facilitator Superfamily
I8N71_RS01490	COG4948	Mandelate Racemase Muconate Lactonizing
I8N71_RS01495	COG2186	Transcriptional regulator
I8N71_RS01500	COG2721	sulfolactate sulfo-lyase activity
I8N71_RS01505	COG3173	Aminoglycoside phosphotransferase
I8N71_RS01515	COG0697	spore germination
I8N71_RS01520	COG0745	RESPONSE REGULATOR receiver
I8N71_RS01525	COG2205	protein histidine kinase activity
I8N71_RS01530	COG1131	(ABC) transporter
I8N71_RS01550	COG3773	Cell wall hydrolase
I8N71_RS01555	COG2304	oxidoreductase activity
I8N71_RS01565	COG3540	Alkaline phosphatase
I8N71_RS01570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8N71_RS01575	COG0805	protein transport
I8N71_RS01580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I8N71_RS01585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8N71_RS01590	COG0477	Major facilitator Superfamily
I8N71_RS01595	COG1309	transcriptional regulator
I8N71_RS01600	COG0252	asparaginase activity
I8N71_RS01605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I8N71_RS01610	COG1714	RDD family
I8N71_RS01615	COG1405	negative regulation of cell septum assembly
I8N71_RS01615	COG3012	SEC-C Motif Domain Protein
I8N71_RS01620	COG3290	protein histidine kinase activity
I8N71_RS01625	COG3279	Response regulator of the LytR AlgR family
I8N71_RS01630	COG4555	ABC transporter
I8N71_RS01635	COG1668	transmembrane transport
I8N71_RS01640	COG0667	Aldo Keto reductase
I8N71_RS01655	COG1595	DNA-templated transcription, initiation
I8N71_RS01660	COG1595	DNA-templated transcription, initiation
I8N71_RS01665	COG1876	peptidase activity
I8N71_RS01670	COG0457	Tetratricopeptide repeat
I8N71_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS01680	COG0366	Alpha amylase catalytic
I8N71_RS01685	COG0803	Belongs to the bacterial solute-binding protein 9 family
I8N71_RS01690	COG1121	(ABC) transporter
I8N71_RS01695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8N71_RS01700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N71_RS01705	COG2310	stress, protein
I8N71_RS01710	COG2310	stress, protein
I8N71_RS01715	COG2310	stress, protein
I8N71_RS01720	COG0861	Integral membrane protein TerC family
I8N71_RS01730	COG3853	Toxic anion resistance protein (TelA)
I8N71_RS01735	COG0477	Major facilitator Superfamily
I8N71_RS01740	COG2814	Major facilitator Superfamily
I8N71_RS01745	COG0640	Transcriptional regulator
I8N71_RS01750	COG0517	IMP dehydrogenase activity
I8N71_RS01750	COG4175	Glycine betaine
I8N71_RS01755	COG4176	ABC-type proline glycine betaine transport system permease component
I8N71_RS01760	COG2113	Glycine betaine
I8N71_RS01765	COG1473	amidohydrolase
I8N71_RS01770	COG1288	antiporter activity
I8N71_RS01780	COG0366	Alpha amylase catalytic
I8N71_RS01785	COG0039	L-malate dehydrogenase activity
I8N71_RS01790	COG1620	l-lactate permease
I8N71_RS01795	COG2814	Major facilitator Superfamily
I8N71_RS01800	COG1846	Transcriptional regulator
I8N71_RS01805	COG1280	lysine exporter protein (LysE YggA)
I8N71_RS01810	COG3403	YqcI/YcgG family
I8N71_RS01815	COG1113	amino acid transport
I8N71_RS01820	COG3665	Urea carboxylase-associated protein
I8N71_RS01825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I8N71_RS01830	COG1660	Displays ATPase and GTPase activities
I8N71_RS01835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I8N71_RS01840	COG2226	methyltransferase
I8N71_RS01845	COG0583	DNA-binding transcription factor activity
I8N71_RS01850	COG3458	cephalosporin-C deacetylase activity
I8N71_RS01855	COG3541	Predicted nucleotidyltransferase
I8N71_RS01860	COG0506	proline dehydrogenase activity
I8N71_RS01865	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS01875	COG2508	Transcriptional regulator
I8N71_RS01880	COG3689	TIGRFAM TIGR03943 family protein
I8N71_RS01885	COG0701	Predicted permease
I8N71_RS01890	COG2267	carboxylic ester hydrolase activity
I8N71_RS01895	COG0492	ferredoxin-NADP+ reductase activity
I8N71_RS01900	COG1587	Uroporphyrinogen-III synthase
I8N71_RS01900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8N71_RS01905	COG2146	nitrite reductase [NAD(P)H] activity
I8N71_RS01910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8N71_RS01915	COG0243	molybdopterin cofactor binding
I8N71_RS01920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8N71_RS01925	COG2223	nitrite transmembrane transporter activity
I8N71_RS01930	COG1469	GTP cyclohydrolase I activity
I8N71_RS01935	COG1376	ErfK ybiS ycfS ynhG family protein
I8N71_RS01945	COG0523	cobalamin synthesis protein
I8N71_RS01950	COG0765	amino acid transport
I8N71_RS01955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N71_RS01965	COG1714	RDD family
I8N71_RS01975	COG2723	6-phospho-beta-galactosidase activity
I8N71_RS01985	COG3209	COG3209 Rhs family protein
I8N71_RS01990	COG3290	protein histidine kinase activity
I8N71_RS01990	COG0840	transmembrane signaling receptor activity
I8N71_RS01995	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I8N71_RS02000	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I8N71_RS02005	COG1733	regulation of RNA biosynthetic process
I8N71_RS02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS02025	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I8N71_RS02030	COG2814	Major facilitator Superfamily
I8N71_RS02040	COG0697	spore germination
I8N71_RS02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N71_RS02055	COG2364	Membrane
I8N71_RS02060	COG1126	abc transporter atp-binding protein
I8N71_RS02065	COG0765	amino acid transport
I8N71_RS02070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N71_RS02075	COG0583	DNA-binding transcription factor activity
I8N71_RS02080	COG0163	prenyltransferase activity
I8N71_RS02085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I8N71_RS02100	COG0596	Alpha beta hydrolase
I8N71_RS02105	COG3104	oligopeptide transport
I8N71_RS02110	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N71_RS02120	COG0697	spore germination
I8N71_RS02130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8N71_RS02135	COG1136	(ABC) transporter
I8N71_RS02140	COG0577	efflux transmembrane transporter activity
I8N71_RS02145	COG0745	RESPONSE REGULATOR receiver
I8N71_RS02150	COG5002	protein histidine kinase activity
I8N71_RS02150	COG3850	Histidine kinase
I8N71_RS02155	COG0457	Tetratricopeptide repeat
I8N71_RS02175	COG0527	aspartate kinase activity
I8N71_RS02180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS02185	COG4605	iron ion homeostasis
I8N71_RS02190	COG4604	ABC transporter, ATP-binding protein
I8N71_RS02195	COG4607	ABC-type enterochelin transport system periplasmic component
I8N71_RS02200	COG2814	Major facilitator Superfamily
I8N71_RS02205	COG1309	transcriptional regulator
I8N71_RS02210	COG0778	Nitroreductase
I8N71_RS02215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I8N71_RS02220	COG0640	Transcriptional regulator
I8N71_RS02225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N71_RS02230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8N71_RS02235	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS02240	COG4975	Glucose uptake
I8N71_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS02250	COG4549	nuclear export factor GLE1
I8N71_RS02255	COG2372	response to copper ion
I8N71_RS02255	COG1276	copper resistance
I8N71_RS02260	COG1349	DNA-binding transcription factor activity
I8N71_RS02270	COG2213	PTS system mannitol-specific
I8N71_RS02275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N71_RS02280	COG0246	Mannitol dehydrogenase
I8N71_RS02285	COG0473	3-isopropylmalate dehydrogenase activity
I8N71_RS02290	COG0681	Belongs to the peptidase S26 family
I8N71_RS02295	COG0412	Dienelactone hydrolase
I8N71_RS02300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I8N71_RS02310	COG0561	phosphatase activity
I8N71_RS02315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I8N71_RS02320	COG1914	H( )-stimulated, divalent metal cation uptake system
I8N71_RS02325	COG4336	lyase activity
I8N71_RS02330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I8N71_RS02335	COG1984	allophanate hydrolase subunit 2
I8N71_RS02340	COG1414	Transcriptional regulator
I8N71_RS02345	COG2755	lipolytic protein G-D-S-L family
I8N71_RS02355	COG2329	Antibiotic biosynthesis monooxygenase
I8N71_RS02360	COG0768	penicillin binding
I8N71_RS02365	COG4989	oxidoreductase activity
I8N71_RS02370	COG3711	transcriptional antiterminator
I8N71_RS02375	COG0318	PFAM AMP-dependent synthetase and ligase
I8N71_RS02380	COG2226	methyltransferase
I8N71_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS02390	COG1917	Cupin 2, conserved barrel domain protein
I8N71_RS02395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N71_RS02400	COG3871	stress protein (general stress protein 26)
I8N71_RS02410	COG2814	Major facilitator Superfamily
I8N71_RS02415	COG1522	sequence-specific DNA binding
I8N71_RS02420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8N71_RS02420	COG0551	DNA topoisomerase type I activity
I8N71_RS02425	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I8N71_RS02430	COG3706	GGDEF domain
I8N71_RS02435	COG5298	Protein conserved in bacteria
I8N71_RS02440	COG1215	transferase activity, transferring glycosyl groups
I8N71_RS02450	COG0531	amino acid
I8N71_RS02455	COG0494	nUDIX hydrolase
I8N71_RS02460	COG0028	Belongs to the TPP enzyme family
I8N71_RS02475	COG1914	H( )-stimulated, divalent metal cation uptake system
I8N71_RS02480	COG2261	transglycosylase associated protein
I8N71_RS02485	COG4876	unkown
I8N71_RS02490	COG2217	Heavy metal translocating P-type atpase
I8N71_RS02495	COG3729	General stress protein
I8N71_RS02500	COG0662	Cupin 2, conserved barrel domain protein
I8N71_RS02505	COG2329	Antibiotic biosynthesis monooxygenase
I8N71_RS02510	COG3546	catalase activity
I8N71_RS02515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I8N71_RS02520	COG3290	protein histidine kinase activity
I8N71_RS02525	COG4565	transcriptional regulatory protein
I8N71_RS02530	COG1301	dicarboxylic acid transport
I8N71_RS02535	COG0628	permease
I8N71_RS02540	COG1131	(ABC) transporter
I8N71_RS02545	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N71_RS02555	COG1960	acyl-CoA dehydrogenase activity
I8N71_RS02570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N71_RS02575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS02580	COG1181	Belongs to the D-alanine--D-alanine ligase family
I8N71_RS02585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I8N71_RS02590	COG0513	Belongs to the DEAD box helicase family
I8N71_RS02595	COG3402	PFAM membrane-flanked domain
I8N71_RS02600	COG3428	Bacterial PH domain
I8N71_RS02605	COG0705	Rhomboid family
I8N71_RS02610	COG0736	holo-[acyl-carrier-protein] synthase activity
I8N71_RS02615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I8N71_RS02620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8N71_RS02625	COG0864	Transcriptional regulator
I8N71_RS02630	COG2337	Toxic component of a toxin-antitoxin (TA) module
I8N71_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N71_RS02640	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N71_RS02645	COG2172	sigma factor antagonist activity
I8N71_RS02650	COG2208	phosphoserine phosphatase activity
I8N71_RS02655	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N71_RS02660	COG2172	sigma factor antagonist activity
I8N71_RS02665	COG1191	sigma factor activity
I8N71_RS02670	COG2208	phosphoserine phosphatase activity
I8N71_RS02685	COG1673	EVE domain
I8N71_RS02690	COG1846	Transcriptional regulator
I8N71_RS02695	COG2183	response to ionizing radiation
I8N71_RS02705	COG3091	SprT-like family
I8N71_RS02745	COG0582	viral genome integration into host DNA
I8N71_RS02750	COG2856	Zn peptidase
I8N71_RS02755	COG1396	sequence-specific DNA binding
I8N71_RS02785	COG1674	ftsk spoiiie
I8N71_RS02790	COG2946	Replication initiation factor
I8N71_RS02825	COG0433	COG0433 Predicted ATPase
I8N71_RS02835	COG5644	endopeptidase inhibitor activity
I8N71_RS02840	COG0791	NLP P60 protein
I8N71_RS02840	COG0741	lytic transglycosylase activity
I8N71_RS02860	COG0457	Tetratricopeptide repeat
I8N71_RS02875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N71_RS02880	COG1522	sequence-specific DNA binding
I8N71_RS02885	COG1522	sequence-specific DNA binding
I8N71_RS02890	COG1335	isochorismatase
I8N71_RS02895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I8N71_RS02900	COG2814	Major facilitator Superfamily
I8N71_RS02920	COG0693	protein deglycase activity
I8N71_RS02925	COG1278	Cold shock
I8N71_RS02930	COG1329	Transcriptional regulator
I8N71_RS02940	COG2207	Transcriptional regulator
I8N71_RS02940	COG1917	Cupin 2, conserved barrel domain protein
I8N71_RS02945	COG0697	spore germination
I8N71_RS02950	COG3708	Transcriptional regulator
I8N71_RS02950	COG2207	Transcriptional regulator
I8N71_RS02955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N71_RS02960	COG0477	Major facilitator Superfamily
I8N71_RS02970	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I8N71_RS02980	COG0697	spore germination
I8N71_RS02985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N71_RS02990	COG2030	dehydratase
I8N71_RS02995	COG3545	Serine hydrolase
I8N71_RS03000	COG1733	regulation of RNA biosynthetic process
I8N71_RS03005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N71_RS03010	COG1733	regulation of RNA biosynthetic process
I8N71_RS03015	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N71_RS03020	COG2814	Major facilitator Superfamily
I8N71_RS03025	COG1309	transcriptional regulator
I8N71_RS03030	COG0640	Transcriptional regulator
I8N71_RS03035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I8N71_RS03045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N71_RS03050	COG0697	spore germination
I8N71_RS03055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N71_RS03060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8N71_RS03065	COG0640	Transcriptional regulator
I8N71_RS03070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8N71_RS03085	COG4585	Histidine kinase
I8N71_RS03090	COG2197	response regulator
I8N71_RS03095	COG2409	Drug exporters of the RND superfamily
I8N71_RS03100	COG0596	Alpha beta hydrolase
I8N71_RS03105	COG1811	Na channel or pump
I8N71_RS03110	COG4978	Transcriptional regulator
I8N71_RS03110	COG0789	Transcriptional regulator
I8N71_RS03115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N71_RS03120	COG0778	Nitroreductase
I8N71_RS03125	COG0346	lactoylglutathione lyase activity
I8N71_RS03130	COG2259	Doxx family
I8N71_RS03135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS03150	COG2323	membrane
I8N71_RS03155	COG2323	membrane
I8N71_RS03160	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N71_RS03175	COG1309	transcriptional regulator
I8N71_RS03185	COG0456	acetyltransferase
I8N71_RS03190	COG0488	(ABC) transporter
I8N71_RS03195	COG1113	amino acid transport
I8N71_RS03200	COG2318	DinB family
I8N71_RS03205	COG1846	Transcriptional regulator
I8N71_RS03210	COG2409	Drug exporters of the RND superfamily
I8N71_RS03210	COG1033	growth of symbiont in host cell
I8N71_RS03215	COG0778	Nitroreductase
I8N71_RS03220	COG1846	Transcriptional regulator
I8N71_RS03225	COG2814	Major facilitator Superfamily
I8N71_RS03230	COG0730	response to heat
I8N71_RS03235	COG1802	Transcriptional regulator
I8N71_RS03240	COG1388	LysM domain
I8N71_RS03240	COG3858	chitin binding
I8N71_RS03245	COG1819	glycosyl
I8N71_RS03255	COG1785	Belongs to the alkaline phosphatase family
I8N71_RS03260	COG5646	InterPro IPR014922
I8N71_RS03270	COG0454	-acetyltransferase
I8N71_RS03275	COG1078	dGTPase activity
I8N71_RS03280	COG1388	LysM domain
I8N71_RS03285	COG2814	Major facilitator Superfamily
I8N71_RS03290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N71_RS03295	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N71_RS03300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N71_RS03305	COG2723	6-phospho-beta-galactosidase activity
I8N71_RS03310	COG2188	Transcriptional regulator
I8N71_RS03315	COG1940	carbohydrate kinase activity
I8N71_RS03320	COG1482	cell wall glycoprotein biosynthetic process
I8N71_RS03325	COG4124	Belongs to the glycosyl hydrolase 26 family
I8N71_RS03370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I8N71_RS03375	COG0802	atpase or kinase
I8N71_RS03380	COG1214	PFAM Peptidase M22, glycoprotease
I8N71_RS03385	COG0456	acetyltransferase
I8N71_RS03390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I8N71_RS03395	COG0488	(ABC) transporter
I8N71_RS03400	COG0315	cyclic pyranopterin monophosphate synthase activity
I8N71_RS03405	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I8N71_RS03410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8N71_RS03415	COG0805	protein transport
I8N71_RS03425	COG1266	CAAX protease self-immunity
I8N71_RS03435	COG0459	protein refolding
I8N71_RS03445	COG3378	Phage plasmid primase P4 family
I8N71_RS03460	COG0270	DNA (cytosine-5-)-methyltransferase activity
I8N71_RS03465	COG0270	DNA (cytosine-5-)-methyltransferase activity
I8N71_RS03485	COG1401	restriction endodeoxyribonuclease activity
I8N71_RS03510	COG0457	Tetratricopeptide repeat
I8N71_RS03515	COG1063	alcohol dehydrogenase
I8N71_RS03520	COG2211	Major facilitator Superfamily
I8N71_RS03525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N71_RS03530	COG1842	Phage shock protein A
I8N71_RS03535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I8N71_RS03540	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I8N71_RS03545	COG4260	virion core protein, lumpy skin disease virus
I8N71_RS03555	COG2814	Major facilitator Superfamily
I8N71_RS03560	COG1063	alcohol dehydrogenase
I8N71_RS03565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I8N71_RS03570	COG0823	Involved in the tonB-independent uptake of proteins
I8N71_RS03585	COG2267	carboxylic ester hydrolase activity
I8N71_RS03595	COG2132	Multicopper oxidase
I8N71_RS03600	COG1113	amino acid transport
I8N71_RS03610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N71_RS03615	COG0714	Associated with various cellular activities
I8N71_RS03620	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I8N71_RS03625	COG1305	Transglutaminase-like
I8N71_RS03630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I8N71_RS03630	COG0519	Catalyzes the synthesis of GMP from XMP
I8N71_RS03635	COG2252	PERMEase
I8N71_RS03640	COG3064	Membrane
I8N71_RS03650	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I8N71_RS03660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I8N71_RS03665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I8N71_RS03670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I8N71_RS03675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I8N71_RS03680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8N71_RS03685	COG0047	phosphoribosylformylglycinamidine synthase activity
I8N71_RS03690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8N71_RS03695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I8N71_RS03700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I8N71_RS03705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I8N71_RS03710	COG0138	bifunctional purine biosynthesis protein purh
I8N71_RS03715	COG0151	Belongs to the GarS family
I8N71_RS03720	COG1522	sequence-specific DNA binding
I8N71_RS03725	COG0531	amino acid
I8N71_RS03735	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I8N71_RS03740	COG1470	cell adhesion involved in biofilm formation
I8N71_RS03745	COG4496	protein, YerC YecD
I8N71_RS03750	COG0069	glutamate synthase activity
I8N71_RS03755	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I8N71_RS03760	COG0210	DNA helicase
I8N71_RS03765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I8N71_RS03770	COG4851	CamS sex pheromone cAM373 precursor
I8N71_RS03775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N71_RS03780	COG1285	pathogenesis
I8N71_RS03785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N71_RS03790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I8N71_RS03795	COG0154	amidase activity
I8N71_RS03800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I8N71_RS03805	COG1309	transcriptional regulator
I8N71_RS03810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8N71_RS03815	COG1597	lipid kinase activity
I8N71_RS03820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8N71_RS03825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N71_RS03830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N71_RS03835	COG1002	Type II restriction enzyme, methylase subunits
I8N71_RS03840	COG1061	Type III restriction enzyme res subunit
I8N71_RS03845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I8N71_RS03865	COG5444	nuclease activity
I8N71_RS03870	COG3391	amine dehydrogenase activity
I8N71_RS03875	COG0457	Tetratricopeptide repeat
I8N71_RS03885	COG0217	transcriptional regulatory protein
I8N71_RS03895	COG1309	transcriptional regulator
I8N71_RS03900	COG3631	Ketosteroid isomerase-related protein
I8N71_RS03905	COG0702	epimerase
I8N71_RS03920	COG3546	catalase activity
I8N71_RS03925	COG0454	-acetyltransferase
I8N71_RS03935	COG5578	integral membrane protein
I8N71_RS03940	COG2972	Histidine kinase
I8N71_RS03945	COG2207	Transcriptional regulator
I8N71_RS03945	COG4753	response regulator
I8N71_RS03950	COG1653	transport
I8N71_RS03955	COG1175	transmembrane transport
I8N71_RS03960	COG0395	ABC-type sugar transport system, permease component
I8N71_RS03965	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I8N71_RS03970	COG2207	Transcriptional regulator
I8N71_RS03975	COG2755	lipolytic protein G-D-S-L family
I8N71_RS03985	COG5578	integral membrane protein
I8N71_RS03990	COG3401	FG-GAP repeat protein
I8N71_RS03995	COG3401	FG-GAP repeat protein
I8N71_RS04000	COG2755	lipolytic protein G-D-S-L family
I8N71_RS04005	COG1874	Beta-galactosidase
I8N71_RS04015	COG1653	transport
I8N71_RS04020	COG4209	transmembrane transport
I8N71_RS04025	COG0395	ABC-type sugar transport system, permease component
I8N71_RS04030	COG1486	melibiose metabolic process
I8N71_RS04035	COG2323	membrane
I8N71_RS04040	COG2329	Antibiotic biosynthesis monooxygenase
I8N71_RS04045	COG0346	lactoylglutathione lyase activity
I8N71_RS04060	COG5583	Uncharacterized small protein (DUF2292)
I8N71_RS04065	COG0670	Belongs to the BI1 family
I8N71_RS04070	COG0697	spore germination
I8N71_RS04075	COG1846	Transcriptional regulator
I8N71_RS04080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8N71_RS04090	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N71_RS04090	COG2124	cytochrome p450
I8N71_RS04095	COG1368	sulfuric ester hydrolase activity
I8N71_RS04100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I8N71_RS04105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N71_RS04110	COG1442	glycosyl transferase family 8
I8N71_RS04115	COG1216	Glycosyl transferase, family 2
I8N71_RS04120	COG1442	glycosyl transferase family 8
I8N71_RS04125	COG2223	nitrite transmembrane transporter activity
I8N71_RS04130	COG1011	Hydrolase
I8N71_RS04135	COG0531	amino acid
I8N71_RS04140	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS04145	COG0840	transmembrane signaling receptor activity
I8N71_RS04150	COG0488	(ABC) transporter
I8N71_RS04160	COG0789	Transcriptional regulator
I8N71_RS04165	COG2814	Major facilitator Superfamily
I8N71_RS04175	COG0488	(ABC) transporter
I8N71_RS04180	COG0513	Belongs to the DEAD box helicase family
I8N71_RS04185	COG0456	acetyltransferase
I8N71_RS04190	COG2130	NADP-dependent
I8N71_RS04195	COG2211	Major facilitator Superfamily
I8N71_RS04200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I8N71_RS04205	COG1120	ATPase activity
I8N71_RS04210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS04215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS04220	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I8N71_RS04235	COG3866	Pectate lyase
I8N71_RS04240	COG0471	metal ion transport
I8N71_RS04245	COG3290	protein histidine kinase activity
I8N71_RS04250	COG4565	transcriptional regulatory protein
I8N71_RS04255	COG3181	Tripartite tricarboxylate transporter family receptor
I8N71_RS04260	COG2851	Citrate transporter
I8N71_RS04265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N71_RS04270	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I8N71_RS04275	COG1254	Belongs to the acylphosphatase family
I8N71_RS04280	COG2258	MOSC domain
I8N71_RS04300	COG0024	Methionine aminopeptidase
I8N71_RS04305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS04305	COG1263	PTS System
I8N71_RS04310	COG1368	sulfuric ester hydrolase activity
I8N71_RS04325	COG1115	amino acid carrier protein
I8N71_RS04330	COG0531	amino acid
I8N71_RS04345	COG0697	spore germination
I8N71_RS04350	COG1263	PTS System
I8N71_RS04350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS04355	COG0366	Alpha amylase catalytic
I8N71_RS04360	COG2188	Transcriptional regulator
I8N71_RS04365	COG0778	Nitroreductase
I8N71_RS04370	COG0737	Belongs to the 5'-nucleotidase family
I8N71_RS04375	COG0693	protein deglycase activity
I8N71_RS04380	COG2814	Major facilitator Superfamily
I8N71_RS04385	COG4840	Belongs to the UPF0435 family
I8N71_RS04390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8N71_RS04395	COG4980	gas vesicle protein
I8N71_RS04400	COG1295	ribonuclease BN
I8N71_RS04405	COG0477	Major facilitator Superfamily
I8N71_RS04415	COG0387	Pfam Sodium calcium exchanger
I8N71_RS04425	COG0668	transmembrane transport
I8N71_RS04430	COG0535	radical SAM domain protein
I8N71_RS04440	COG0726	polysaccharide deacetylase
I8N71_RS04445	COG2084	Dehydrogenase
I8N71_RS04450	COG0598	Magnesium transport protein CorA
I8N71_RS04455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I8N71_RS04460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8N71_RS04470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8N71_RS04475	COG4637	Psort location Cytoplasmic, score
I8N71_RS04485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N71_RS04490	COG0022	dehydrogenase e1 component
I8N71_RS04495	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N71_RS04500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N71_RS04505	COG3284	Transcriptional regulator
I8N71_RS04515	COG1742	UPF0060 membrane protein
I8N71_RS04540	COG4842	Belongs to the WXG100 family
I8N71_RS04545	COG1486	melibiose metabolic process
I8N71_RS04550	COG1737	Transcriptional regulator
I8N71_RS04555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS04555	COG1263	PTS System
I8N71_RS04560	COG1132	(ABC) transporter
I8N71_RS04565	COG1132	(ABC) transporter
I8N71_RS04570	COG2259	Doxx family
I8N71_RS04575	COG2514	catechol 2,3-dioxygenase activity
I8N71_RS04580	COG1917	Cupin 2, conserved barrel domain protein
I8N71_RS04580	COG4977	sequence-specific DNA binding
I8N71_RS04585	COG2814	Major facilitator Superfamily
I8N71_RS04590	COG1082	Xylose isomerase domain protein TIM barrel
I8N71_RS04595	COG0673	inositol 2-dehydrogenase activity
I8N71_RS04600	COG4585	Histidine kinase
I8N71_RS04605	COG2197	response regulator
I8N71_RS04610	COG1131	(ABC) transporter
I8N71_RS04615	COG0842	Transport permease protein
I8N71_RS04615	COG1511	domain protein
I8N71_RS04620	COG0842	Transport permease protein
I8N71_RS04625	COG1695	Transcriptional regulator
I8N71_RS04630	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I8N71_RS04635	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I8N71_RS04640	COG1309	transcriptional regulator
I8N71_RS04645	COG2814	Major facilitator Superfamily
I8N71_RS04650	COG2318	DinB family
I8N71_RS04655	COG2814	Major facilitator Superfamily
I8N71_RS04660	COG1846	Transcriptional regulator
I8N71_RS04665	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I8N71_RS04665	COG0392	lysyltransferase activity
I8N71_RS04670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N71_RS04675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS04680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS04685	COG0384	phenazine biosynthesis protein PhzF
I8N71_RS04690	COG0778	Nitroreductase
I8N71_RS04705	COG1090	epimerase
I8N71_RS04710	COG2137	regulation of response to DNA damage stimulus
I8N71_RS04720	COG2814	Major facilitator Superfamily
I8N71_RS04735	COG3103	Sh3 type 3 domain protein
I8N71_RS04740	COG5658	integral membrane protein
I8N71_RS04745	COG0596	Alpha beta hydrolase
I8N71_RS04750	COG0463	Glycosyl transferase, family 2
I8N71_RS04755	COG4485	Bacterial membrane protein, YfhO
I8N71_RS04760	COG1988	membrane-bound metal-dependent
I8N71_RS04765	COG1194	a g-specific adenine glycosylase
I8N71_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS04790	COG3557	Belongs to the UPF0374 family
I8N71_RS04795	COG1132	(ABC) transporter
I8N71_RS04800	COG4129	membrane
I8N71_RS04805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I8N71_RS04810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I8N71_RS04815	COG0735	belongs to the Fur family
I8N71_RS04925	COG4326	sporulation control protein
I8N71_RS04935	COG5577	PFAM Coat F domain
I8N71_RS04940	COG3340	Belongs to the peptidase S51 family
I8N71_RS04945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I8N71_RS04950	COG0277	FAD linked oxidase domain protein
I8N71_RS04960	COG0753	catalase activity
I8N71_RS04965	COG1116	anion transmembrane transporter activity
I8N71_RS04970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8N71_RS04975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8N71_RS04980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N71_RS04990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I8N71_RS05000	COG1476	TRANSCRIPTIONal
I8N71_RS05010	COG3382	B3 4 domain protein
I8N71_RS05015	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I8N71_RS05025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I8N71_RS05030	COG0789	Transcriptional regulator
I8N71_RS05035	COG1664	Polymer-forming cytoskeletal
I8N71_RS05040	COG1664	Polymer-forming cytoskeletal
I8N71_RS05045	COG2766	serine protein kinase
I8N71_RS05050	COG2718	Belongs to the UPF0229 family
I8N71_RS05055	COG1846	Transcriptional regulator
I8N71_RS05060	COG1566	PFAM secretion protein HlyD family protein
I8N71_RS05065	COG2814	Major facilitator Superfamily
I8N71_RS05070	COG0655	NAD(P)H dehydrogenase (quinone) activity
I8N71_RS05090	COG1725	Transcriptional regulator
I8N71_RS05095	COG1131	(ABC) transporter
I8N71_RS05100	COG1131	(ABC) transporter
I8N71_RS05105	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N71_RS05110	COG1278	Cold shock
I8N71_RS05115	COG1464	Belongs to the NlpA lipoprotein family
I8N71_RS05120	COG3706	GGDEF domain
I8N71_RS05125	COG1823	symporter activity
I8N71_RS05145	COG5577	PFAM Coat F domain
I8N71_RS05150	COG0737	Belongs to the 5'-nucleotidase family
I8N71_RS05150	COG4085	toxin activity
I8N71_RS05150	COG1525	nuclease
I8N71_RS05155	COG3764	Sortase (surface protein transpeptidase)
I8N71_RS05160	COG0564	pseudouridine synthase activity
I8N71_RS05170	COG0517	IMP dehydrogenase activity
I8N71_RS05175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8N71_RS05180	COG3153	acetyltransferase
I8N71_RS05180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8N71_RS05185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N71_RS05190	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I8N71_RS05195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I8N71_RS05200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I8N71_RS05205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I8N71_RS05210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8N71_RS05215	COG2203	Gaf domain
I8N71_RS05215	COG4585	Histidine kinase
I8N71_RS05220	COG2197	response regulator
I8N71_RS05225	COG0431	NADPH-dependent FMN reductase
I8N71_RS05240	COG0791	NLP P60 protein
I8N71_RS05240	COG1388	LysM domain
I8N71_RS05245	COG1959	2 iron, 2 sulfur cluster binding
I8N71_RS05250	COG0668	transmembrane transport
I8N71_RS05255	COG2719	SpoVR family
I8N71_RS05260	COG1785	Belongs to the alkaline phosphatase family
I8N71_RS05265	COG0791	NLP P60 protein
I8N71_RS05265	COG1388	LysM domain
I8N71_RS05270	COG0583	DNA-binding transcription factor activity
I8N71_RS05275	COG0372	Belongs to the citrate synthase family
I8N71_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS05285	COG0531	amino acid
I8N71_RS05290	COG0733	neurotransmitter:sodium symporter activity
I8N71_RS05295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N71_RS05300	COG0456	acetyltransferase
I8N71_RS05315	COG1595	DNA-templated transcription, initiation
I8N71_RS05320	COG0667	Aldo Keto reductase
I8N71_RS05325	COG0204	Acyl-transferase
I8N71_RS05330	COG1253	flavin adenine dinucleotide binding
I8N71_RS05335	COG0789	Transcriptional regulator
I8N71_RS05340	COG0436	Aminotransferase
I8N71_RS05345	COG1253	flavin adenine dinucleotide binding
I8N71_RS05350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8N71_RS05355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8N71_RS05360	COG0584	glycerophosphoryl diester phosphodiesterase
I8N71_RS05370	COG0668	transmembrane transport
I8N71_RS05375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I8N71_RS05380	COG0726	polysaccharide deacetylase
I8N71_RS05385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N71_RS05390	COG1757	Na H antiporter
I8N71_RS05395	COG0589	response to stress
I8N71_RS05405	COG1132	(ABC) transporter
I8N71_RS05410	COG1132	(ABC) transporter
I8N71_RS05415	COG0702	epimerase
I8N71_RS05435	COG0189	ligase activity
I8N71_RS05440	COG0189	ligase activity
I8N71_RS05445	COG4399	Belongs to the UPF0754 family
I8N71_RS05450	COG3679	Belongs to the UPF0342 family
I8N71_RS05455	COG4335	DNA alkylation repair
I8N71_RS05460	COG0561	phosphatase activity
I8N71_RS05465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8N71_RS05470	COG0475	glutathione-regulated potassium exporter activity
I8N71_RS05475	COG0490	domain, Protein
I8N71_RS05485	COG1024	Enoyl-CoA hydratase
I8N71_RS05495	COG4152	abc transporter atp-binding protein
I8N71_RS05500	COG1668	transmembrane transport
I8N71_RS05505	COG0420	3'-5' exonuclease activity
I8N71_RS05510	COG4717	serine-type aminopeptidase activity
I8N71_RS05515	COG3481	metal-dependent phosphohydrolase, HD sub domain
I8N71_RS05525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8N71_RS05555	COG1846	Transcriptional regulator
I8N71_RS05560	COG4980	gas vesicle protein
I8N71_RS05575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I8N71_RS05580	COG0537	adenosine 5'-monophosphoramidase activity
I8N71_RS05585	COG1131	(ABC) transporter
I8N71_RS05590	COG4473	ABC transporter
I8N71_RS05600	COG1473	amidohydrolase
I8N71_RS05605	COG3069	C4-dicarboxylate transmembrane transporter activity
I8N71_RS05615	COG2329	Antibiotic biosynthesis monooxygenase
I8N71_RS05620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N71_RS05625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I8N71_RS05630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I8N71_RS05635	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I8N71_RS05640	COG1309	transcriptional regulator
I8N71_RS05645	COG1511	domain protein
I8N71_RS05650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N71_RS05655	COG4377	Putative membrane peptidase family (DUF2324)
I8N71_RS05665	COG1363	Peptidase, m42
I8N71_RS05670	COG4405	Protein conserved in bacteria
I8N71_RS05675	COG1301	dicarboxylic acid transport
I8N71_RS05685	COG1234	tRNA 3'-trailer cleavage
I8N71_RS05690	COG0095	Lipoate-protein ligase
I8N71_RS05695	COG0702	epimerase
I8N71_RS05700	COG0318	PFAM AMP-dependent synthetase and ligase
I8N71_RS05710	COG0501	Belongs to the peptidase M48B family
I8N71_RS05715	COG1404	Belongs to the peptidase S8 family
I8N71_RS05720	COG0456	acetyltransferase
I8N71_RS05725	COG0604	alcohol dehydrogenase
I8N71_RS05730	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I8N71_RS05735	COG0406	alpha-ribazole phosphatase activity
I8N71_RS05740	COG0183	Belongs to the thiolase family
I8N71_RS05745	COG0318	PFAM AMP-dependent synthetase and ligase
I8N71_RS05750	COG1268	BioY protein
I8N71_RS05755	COG0840	transmembrane signaling receptor activity
I8N71_RS05760	COG0723	plastoquinol--plastocyanin reductase activity
I8N71_RS05760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N71_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS05775	COG4903	ComK protein
I8N71_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS05790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N71_RS05805	COG0398	Pfam SNARE associated Golgi protein
I8N71_RS05810	COG0681	Belongs to the peptidase S26 family
I8N71_RS05815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8N71_RS05820	COG1846	Transcriptional regulator
I8N71_RS05825	COG0738	Major facilitator superfamily
I8N71_RS05830	COG0673	inositol 2-dehydrogenase activity
I8N71_RS05835	COG0561	phosphatase activity
I8N71_RS05840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N71_RS05845	COG1609	Transcriptional regulator
I8N71_RS05850	COG3180	Ammonia monooxygenase
I8N71_RS05855	COG0477	Major facilitator Superfamily
I8N71_RS05855	COG2814	Major facilitator Superfamily
I8N71_RS05860	COG4533	DNA binding
I8N71_RS05870	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I8N71_RS05875	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I8N71_RS05880	COG1074	ATP-dependent DNA helicase activity
I8N71_RS05885	COG0420	3'-5' exonuclease activity
I8N71_RS05890	COG0419	ATPase involved in DNA repair
I8N71_RS05895	COG1403	HNH endonuclease
I8N71_RS05935	COG5337	Spore coat protein CotH
I8N71_RS05940	COG0179	Fumarylacetoacetate (FAA) hydrolase
I8N71_RS05950	COG1404	Belongs to the peptidase S8 family
I8N71_RS05960	COG0367	asparagine synthase
I8N71_RS05965	COG2318	DinB family
I8N71_RS05970	COG1562	ergosterol biosynthetic process
I8N71_RS05975	COG0534	Mate efflux family protein
I8N71_RS05980	COG2207	Transcriptional regulator
I8N71_RS05980	COG1917	Cupin 2, conserved barrel domain protein
I8N71_RS05985	COG1609	Transcriptional regulator
I8N71_RS05990	COG0673	inositol 2-dehydrogenase activity
I8N71_RS05995	COG2318	DinB family
I8N71_RS06000	COG1279	arginine transmembrane transporter activity
I8N71_RS06005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N71_RS06010	COG1357	PFAM Pentapeptide repeats (8 copies)
I8N71_RS06015	COG2267	carboxylic ester hydrolase activity
I8N71_RS06020	COG0529	Catalyzes the synthesis of activated sulfate
I8N71_RS06025	COG2046	Belongs to the sulfate adenylyltransferase family
I8N71_RS06030	COG0175	sulfate reduction
I8N71_RS06035	COG2045	Belongs to the ComB family
I8N71_RS06040	COG1809	phosphosulfolactate synthase activity
I8N71_RS06045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N71_RS06050	COG4948	Mandelate Racemase Muconate Lactonizing
I8N71_RS06055	COG2814	Major facilitator Superfamily
I8N71_RS06060	COG0454	-acetyltransferase
I8N71_RS06065	COG2153	protein acetylation
I8N71_RS06070	COG0646	methionine synthase
I8N71_RS06070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I8N71_RS06075	COG1666	GTP binding
I8N71_RS06080	COG2996	Protein conserved in bacteria
I8N71_RS06100	COG1695	Transcriptional regulator
I8N71_RS06115	COG3227	Zinc metalloprotease (Elastase)
I8N71_RS06120	COG1307	EDD domain protein, DegV family
I8N71_RS06125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N71_RS06145	COG0561	phosphatase activity
I8N71_RS06150	COG1073	alpha beta
I8N71_RS06155	COG2151	metal-sulfur cluster biosynthetic enzyme
I8N71_RS06165	COG0277	FAD linked oxidase domain protein
I8N71_RS06170	COG2271	Major facilitator Superfamily
I8N71_RS06175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I8N71_RS06180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I8N71_RS06190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8N71_RS06195	COG0505	Belongs to the CarA family
I8N71_RS06200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8N71_RS06205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I8N71_RS06220	COG2267	carboxylic ester hydrolase activity
I8N71_RS06230	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N71_RS06245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N71_RS06250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8N71_RS06255	COG5504	Zn-dependent protease
I8N71_RS06260	COG0444	Belongs to the ABC transporter superfamily
I8N71_RS06265	COG4608	Belongs to the ABC transporter superfamily
I8N71_RS06275	COG0601	transmembrane transport
I8N71_RS06280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N71_RS06290	COG0180	Tryptophanyl-tRNA synthetase
I8N71_RS06295	COG4166	transmembrane transport
I8N71_RS06300	COG0601	transmembrane transport
I8N71_RS06305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N71_RS06310	COG0444	Belongs to the ABC transporter superfamily
I8N71_RS06315	COG4608	Belongs to the ABC transporter superfamily
I8N71_RS06320	COG2814	Major facilitator Superfamily
I8N71_RS06325	COG0456	acetyltransferase
I8N71_RS06330	COG1393	Belongs to the ArsC family
I8N71_RS06335	COG0861	Integral membrane protein TerC family
I8N71_RS06345	COG4862	establishment of competence for transformation
I8N71_RS06355	COG4469	Competence protein
I8N71_RS06360	COG1164	Oligoendopeptidase f
I8N71_RS06370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8N71_RS06375	COG2346	COG2346, Truncated hemoglobins
I8N71_RS06380	COG0741	lytic transglycosylase activity
I8N71_RS06385	COG4116	CYTH
I8N71_RS06395	COG2357	RelA SpoT domain protein
I8N71_RS06400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8N71_RS06405	COG0564	pseudouridine synthase activity
I8N71_RS06410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I8N71_RS06415	COG0569	domain protein
I8N71_RS06415	COG0475	glutathione-regulated potassium exporter activity
I8N71_RS06420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I8N71_RS06425	COG0352	thiamine-phosphate diphosphorylase activity
I8N71_RS06430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N71_RS06435	COG2104	thiamine diphosphate biosynthetic process
I8N71_RS06440	COG2022	thiamine diphosphate biosynthetic process
I8N71_RS06445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N71_RS06450	COG0351	phosphomethylpyrimidine kinase
I8N71_RS06455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I8N71_RS06510	COG0210	DNA helicase
I8N71_RS06520	COG2153	protein acetylation
I8N71_RS06525	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I8N71_RS06530	COG2382	esterase
I8N71_RS06535	COG0626	cystathionine gamma-synthase activity
I8N71_RS06540	COG0626	cystathionine gamma-synthase activity
I8N71_RS06545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N71_RS06550	COG5505	Protein of unknown function (DUF819)
I8N71_RS06585	COG3677	Transposase
I8N71_RS06600	COG5484	DNA packaging
I8N71_RS06605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I8N71_RS06610	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS06620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N71_RS06620	COG3711	transcriptional antiterminator
I8N71_RS06625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N71_RS06625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N71_RS06625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N71_RS06630	COG1482	cell wall glycoprotein biosynthetic process
I8N71_RS06640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N71_RS06650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I8N71_RS06665	COG0109	protoheme IX farnesyltransferase activity
I8N71_RS06675	COG0726	polysaccharide deacetylase
I8N71_RS06690	COG5504	Zn-dependent protease
I8N71_RS06695	COG2205	protein histidine kinase activity
I8N71_RS06705	COG3383	formate dehydrogenase (NAD+) activity
I8N71_RS06710	COG2427	Protein of unknown function (DUF1641)
I8N71_RS06720	COG1051	belongs to the nudix hydrolase family
I8N71_RS06730	COG2124	cytochrome p450
I8N71_RS06735	COG1819	glycosyl
I8N71_RS06745	COG1587	Uroporphyrinogen-III synthase
I8N71_RS06750	COG0390	transport system, permease component
I8N71_RS06755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N71_RS06760	COG0697	spore germination
I8N71_RS06765	COG4297	protein containing double-stranded beta helix domain
I8N71_RS06775	COG1252	NADH dehydrogenase
I8N71_RS06780	COG1904	glucuronate isomerase
I8N71_RS06785	COG2211	Major facilitator Superfamily
I8N71_RS06790	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I8N71_RS06795	COG1063	alcohol dehydrogenase
I8N71_RS06800	COG1312	Catalyzes the dehydration of D-mannonate
I8N71_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS06810	COG2271	Major facilitator Superfamily
I8N71_RS06815	COG1609	Transcriptional regulator
I8N71_RS06820	COG0246	Mannitol dehydrogenase
I8N71_RS06825	COG2721	sulfolactate sulfo-lyase activity
I8N71_RS06830	COG0730	response to heat
I8N71_RS06835	COG2318	DinB family
I8N71_RS06840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8N71_RS06845	COG0457	Tetratricopeptide repeat
I8N71_RS06855	COG2350	Protein conserved in bacteria
I8N71_RS06860	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS06860	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS06860	COG1388	LysM domain
I8N71_RS06870	COG4195	phage-related replication protein
I8N71_RS06875	COG3546	catalase activity
I8N71_RS06880	COG2856	Zn peptidase
I8N71_RS06885	COG1396	sequence-specific DNA binding
I8N71_RS06895	COG1522	sequence-specific DNA binding
I8N71_RS06900	COG1484	DNA-dependent DNA replication
I8N71_RS06920	COG1595	DNA-templated transcription, initiation
I8N71_RS06925	COG5484	DNA packaging
I8N71_RS06925	COG3728	DNA packaging
I8N71_RS06930	COG1783	phage Terminase large subunit
I8N71_RS06935	COG5518	Phage portal protein
I8N71_RS06940	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I8N71_RS06945	COG4653	Phage capsid family
I8N71_RS06995	COG5412	phage tail tape measure protein
I8N71_RS06995	COG3953	SLT domain
I8N71_RS07000	COG1652	LysM domain
I8N71_RS07005	COG4193	domain, Protein
I8N71_RS07015	COG3628	GPW Gp25 family protein
I8N71_RS07020	COG3299	homolog of phage Mu protein gp47
I8N71_RS07025	COG3778	Protein conserved in bacteria
I8N71_RS07065	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS07065	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS07085	COG0306	phosphate transporter
I8N71_RS07090	COG1392	Phosphate transport regulator
I8N71_RS07095	COG0531	amino acid
I8N71_RS07100	COG0346	lactoylglutathione lyase activity
I8N71_RS07110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8N71_RS07115	COG0463	Glycosyl transferase, family 2
I8N71_RS07125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N71_RS07130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N71_RS07135	COG2362	D-Aminopeptidase
I8N71_RS07140	COG0601	transmembrane transport
I8N71_RS07145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N71_RS07150	COG0444	Belongs to the ABC transporter superfamily
I8N71_RS07155	COG4166	transmembrane transport
I8N71_RS07160	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8N71_RS07165	COG4948	Mandelate Racemase Muconate Lactonizing
I8N71_RS07170	COG0791	NLP P60 protein
I8N71_RS07175	COG4608	Belongs to the ABC transporter superfamily
I8N71_RS07180	COG2706	6-phosphogluconolactonase activity
I8N71_RS07185	COG1834	amidinotransferase
I8N71_RS07190	COG1607	acyl-coa hydrolase
I8N71_RS07195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8N71_RS07195	COG1017	nitric oxide dioxygenase activity
I8N71_RS07205	COG2323	membrane
I8N71_RS07210	COG2318	DinB family
I8N71_RS07215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N71_RS07220	COG2076	Multidrug Resistance protein
I8N71_RS07225	COG2076	Multidrug Resistance protein
I8N71_RS07230	COG0788	formyltetrahydrofolate deformylase activity
I8N71_RS07235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8N71_RS07240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I8N71_RS07245	COG1764	response to oxidative stress
I8N71_RS07250	COG1846	Transcriptional regulator
I8N71_RS07255	COG1764	response to oxidative stress
I8N71_RS07265	COG0590	tRNA wobble adenosine to inosine editing
I8N71_RS07270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I8N71_RS07275	COG1404	Belongs to the peptidase S8 family
I8N71_RS07280	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N71_RS07285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I8N71_RS07290	COG1122	ATPase activity
I8N71_RS07295	COG4721	ABC-type cobalt transport system, permease component
I8N71_RS07305	COG0745	RESPONSE REGULATOR receiver
I8N71_RS07310	COG3850	Histidine kinase
I8N71_RS07310	COG5002	protein histidine kinase activity
I8N71_RS07315	COG3212	peptidase
I8N71_RS07320	COG3212	peptidase
I8N71_RS07330	COG2239	Acts as a magnesium transporter
I8N71_RS07335	COG0789	Transcriptional regulator
I8N71_RS07350	COG1846	Transcriptional regulator
I8N71_RS07355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I8N71_RS07360	COG0726	polysaccharide deacetylase
I8N71_RS07365	COG1408	metallophosphoesterase
I8N71_RS07375	COG0463	Glycosyl transferase, family 2
I8N71_RS07380	COG1793	dna ligase
I8N71_RS07380	COG3285	dna ligase
I8N71_RS07385	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I8N71_RS07390	COG5001	Diguanylate cyclase
I8N71_RS07390	COG3300	MHYT domain
I8N71_RS07395	COG0586	Pfam SNARE associated Golgi protein
I8N71_RS07400	COG0861	Integral membrane protein TerC family
I8N71_RS07405	COG1191	sigma factor activity
I8N71_RS07425	COG0501	Belongs to the peptidase M48B family
I8N71_RS07430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I8N71_RS07445	COG3594	Acyltransferase
I8N71_RS07450	COG5002	protein histidine kinase activity
I8N71_RS07455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8N71_RS07465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I8N71_RS07470	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I8N71_RS07475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8N71_RS07480	COG0436	Aminotransferase
I8N71_RS07485	COG1850	ribulose-bisphosphate carboxylase activity
I8N71_RS07490	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
I8N71_RS07495	COG0235	Class ii aldolase
I8N71_RS07500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I8N71_RS07505	COG3339	Conserved Protein
I8N71_RS07520	COG3852	Histidine kinase
I8N71_RS07525	COG1846	Transcriptional regulator
I8N71_RS07530	COG1360	Flagellar Motor Protein
I8N71_RS07535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I8N71_RS07540	COG0542	response to heat
I8N71_RS07545	COG3949	Membrane
I8N71_RS07550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I8N71_RS07555	COG0720	synthase
I8N71_RS07560	COG0602	queuosine metabolic process
I8N71_RS07565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I8N71_RS07570	COG1733	regulation of RNA biosynthetic process
I8N71_RS07575	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS07585	COG1388	LysM domain
I8N71_RS07600	COG4873	Protein conserved in bacteria
I8N71_RS07610	COG3773	Cell wall hydrolase
I8N71_RS07615	COG2244	polysaccharide biosynthetic process
I8N71_RS07620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS07625	COG2217	Heavy metal translocating P-type atpase
I8N71_RS07635	COG0006	proline dipeptidase activity
I8N71_RS07640	COG1609	Transcriptional regulator
I8N71_RS07645	COG3711	transcriptional antiterminator
I8N71_RS07650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS07650	COG2190	(PTS) system
I8N71_RS07650	COG1263	PTS System
I8N71_RS07655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N71_RS07660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I8N71_RS07670	COG1533	DNA photolyase activity
I8N71_RS07675	COG0456	acetyltransferase
I8N71_RS07680	COG0840	transmembrane signaling receptor activity
I8N71_RS07685	COG2084	Dehydrogenase
I8N71_RS07690	COG2340	Cysteine-rich secretory protein family
I8N71_RS07695	COG0768	penicillin binding
I8N71_RS07700	COG4191	Histidine kinase
I8N71_RS07705	COG0436	Aminotransferase
I8N71_RS07715	COG0835	chemotaxis
I8N71_RS07715	COG0784	Response regulator, receiver
I8N71_RS07725	COG2814	Major facilitator Superfamily
I8N71_RS07730	COG1376	ErfK ybiS ycfS ynhG family protein
I8N71_RS07735	COG1408	metallophosphoesterase
I8N71_RS07740	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS07745	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS07750	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS07760	COG2200	EAL domain
I8N71_RS07765	COG4703	Protein of unknown function (DUF1797)
I8N71_RS07770	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I8N71_RS07780	COG0517	IMP dehydrogenase activity
I8N71_RS07785	COG0583	DNA-binding transcription factor activity
I8N71_RS07790	COG0716	FMN binding
I8N71_RS07800	COG0716	FMN binding
I8N71_RS07805	COG2171	N-acyltransferase activity
I8N71_RS07810	COG1473	amidohydrolase
I8N71_RS07820	COG0668	transmembrane transport
I8N71_RS07825	COG0450	alkyl hydroperoxide reductase
I8N71_RS07830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS07845	COG0746	molybdenum cofactor guanylyltransferase activity
I8N71_RS07850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N71_RS07855	COG0303	'Molybdopterin
I8N71_RS07860	COG1763	Mo-molybdopterin cofactor biosynthetic process
I8N71_RS07865	COG0314	molybdopterin synthase activity
I8N71_RS07870	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I8N71_RS07875	COG1132	(ABC) transporter
I8N71_RS07880	COG1132	(ABC) transporter
I8N71_RS07890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8N71_RS07895	COG1136	(ABC) transporter
I8N71_RS07900	COG0577	efflux transmembrane transporter activity
I8N71_RS07905	COG1349	DNA-binding transcription factor activity
I8N71_RS07910	COG1105	Belongs to the carbohydrate kinase PfkB family
I8N71_RS07915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N71_RS07915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N71_RS07915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N71_RS07920	COG0681	Belongs to the peptidase S26 family
I8N71_RS07930	COG0488	(ABC) transporter
I8N71_RS07935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I8N71_RS07940	COG2309	aminopeptidase activity
I8N71_RS07950	COG1077	Cell shape determining protein MreB Mrl
I8N71_RS07955	COG2002	toxin-antitoxin pair type II binding
I8N71_RS07960	COG3852	Histidine kinase
I8N71_RS07965	COG2105	PFAM AIG2 family protein
I8N71_RS07965	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I8N71_RS07970	COG0569	domain protein
I8N71_RS07975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I8N71_RS07980	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8N71_RS07985	COG5503	Protein of unknown function (DUF1447)
I8N71_RS07990	COG0561	phosphatase activity
I8N71_RS07995	COG0242	peptide deformylase activity
I8N71_RS08005	COG0497	DNA recombination
I8N71_RS08010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N71_RS08015	COG0022	dehydrogenase e1 component
I8N71_RS08020	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N71_RS08025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N71_RS08030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS08040	COG1982	Orn Lys Arg decarboxylase major
I8N71_RS08045	COG4476	Belongs to the UPF0223 family
I8N71_RS08050	COG4493	Belongs to the UPF0637 family
I8N71_RS08060	COG0483	inositol monophosphate 1-phosphatase activity
I8N71_RS08070	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I8N71_RS08090	COG1595	DNA-templated transcription, initiation
I8N71_RS08110	COG1217	gtp-binding protein TYPA
I8N71_RS08120	COG4896	Protein conserved in bacteria
I8N71_RS08130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I8N71_RS08135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8N71_RS08140	COG2066	Belongs to the glutaminase family
I8N71_RS08145	COG4838	Belongs to the UPF0358 family
I8N71_RS08150	COG0772	Belongs to the SEDS family
I8N71_RS08155	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I8N71_RS08160	COG1612	heme a metabolic process
I8N71_RS08165	COG0109	protoheme IX farnesyltransferase activity
I8N71_RS08170	COG2010	Cytochrome c
I8N71_RS08170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8N71_RS08175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8N71_RS08180	COG1845	cytochrome c oxidase, subunit III
I8N71_RS08185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I8N71_RS08190	COG3336	cytochrome c oxidase
I8N71_RS08200	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I8N71_RS08205	COG2340	Cysteine-rich secretory protein family
I8N71_RS08220	COG3679	Belongs to the UPF0342 family
I8N71_RS08225	COG4471	UPF0298 protein
I8N71_RS08230	COG0742	ribosomal rna small subunit methyltransferase
I8N71_RS08235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I8N71_RS08240	COG3314	Sporulation integral membrane protein YlbJ
I8N71_RS08245	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8N71_RS08250	COG3480	Lon protease (S16) C-terminal proteolytic domain
I8N71_RS08255	COG1323	Belongs to the UPF0348 family
I8N71_RS08265	COG1399	metal-binding, possibly nucleic acid-binding protein
I8N71_RS08280	COG0454	-acetyltransferase
I8N71_RS08285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I8N71_RS08290	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I8N71_RS08295	COG2001	Belongs to the MraZ family
I8N71_RS08300	COG0275	rRNA processing
I8N71_RS08305	COG4839	cell division protein FtsL
I8N71_RS08310	COG0768	penicillin binding
I8N71_RS08315	COG0768	penicillin binding
I8N71_RS08320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I8N71_RS08325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I8N71_RS08330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I8N71_RS08335	COG0772	Belongs to the SEDS family
I8N71_RS08340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I8N71_RS08345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I8N71_RS08350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I8N71_RS08355	COG3879	Bacterial protein of unknown function (DUF881)
I8N71_RS08360	COG3879	Bacterial protein of unknown function (DUF881)
I8N71_RS08365	COG3856	small basic protein
I8N71_RS08370	COG0849	cell division
I8N71_RS08375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I8N71_RS08380	COG4412	M6 family metalloprotease domain protein
I8N71_RS08380	COG1404	Belongs to the peptidase S8 family
I8N71_RS08390	COG1191	sigma factor activity
I8N71_RS08395	COG1191	sigma factor activity
I8N71_RS08400	COG1119	ATPase activity
I8N71_RS08405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N71_RS08410	COG1873	PFAM PRC-barrel domain
I8N71_RS08415	COG1496	oxidoreductase activity
I8N71_RS08420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I8N71_RS08425	COG1799	cell septum assembly
I8N71_RS08430	COG0762	integral membrane protein
I8N71_RS08435	COG2302	S4 RNA-binding domain
I8N71_RS08440	COG3599	regulation of cell shape
I8N71_RS08445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I8N71_RS08450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N71_RS08455	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I8N71_RS08460	COG0564	pseudouridine synthase activity
I8N71_RS08465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I8N71_RS08470	COG2233	PERMEase
I8N71_RS08475	COG0540	Belongs to the ATCase OTCase family
I8N71_RS08480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8N71_RS08485	COG0505	Belongs to the CarA family
I8N71_RS08490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8N71_RS08495	COG0543	2 iron, 2 sulfur cluster binding
I8N71_RS08500	COG0167	dihydroorotate dehydrogenase activity
I8N71_RS08505	COG0284	orotidine-5'-phosphate decarboxylase activity
I8N71_RS08510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I8N71_RS08515	COG0175	sulfate reduction
I8N71_RS08520	COG0306	phosphate transporter
I8N71_RS08525	COG2046	Belongs to the sulfate adenylyltransferase family
I8N71_RS08530	COG0529	Catalyzes the synthesis of activated sulfate
I8N71_RS08535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8N71_RS08540	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I8N71_RS08545	COG1648	precorrin-2 dehydrogenase activity
I8N71_RS08550	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I8N71_RS08555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I8N71_RS08560	COG1561	YicC-like family, N-terminal region
I8N71_RS08570	COG0194	GDP metabolic process
I8N71_RS08575	COG1758	RNA polymerase activity
I8N71_RS08580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8N71_RS08585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I8N71_RS08590	COG0242	peptide deformylase activity
I8N71_RS08595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I8N71_RS08600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I8N71_RS08600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I8N71_RS08605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I8N71_RS08610	COG0631	protein serine/threonine phosphatase activity
I8N71_RS08615	COG0515	serine threonine protein kinase
I8N71_RS08615	COG2815	serine threonine protein kinase
I8N71_RS08620	COG1162	GTPase activity
I8N71_RS08625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I8N71_RS08630	COG1564	THIamine pyrophosphokinase
I8N71_RS08640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I8N71_RS08645	COG1302	Protein conserved in bacteria
I8N71_RS08650	COG1461	Dihydroxyacetone kinase
I8N71_RS08655	COG1760	l-serine dehydratase
I8N71_RS08660	COG1760	l-serine dehydratase
I8N71_RS08665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I8N71_RS08670	COG1349	DNA-binding transcription factor activity
I8N71_RS08670	COG2050	protein possibly involved in aromatic compounds catabolism
I8N71_RS08675	COG0416	fatty acid biosynthetic process
I8N71_RS08680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I8N71_RS08685	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS08695	COG0571	ribonuclease III activity
I8N71_RS08700	COG1196	nuclear chromosome segregation
I8N71_RS08705	COG0552	protein localization to endoplasmic reticulum
I8N71_RS08715	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I8N71_RS08720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I8N71_RS08725	COG0228	four-way junction DNA binding
I8N71_RS08730	COG1837	Belongs to the UPF0109 family
I8N71_RS08740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I8N71_RS08745	COG0336	Belongs to the RNA methyltransferase TrmD family
I8N71_RS08750	COG0335	large ribosomal subunit rRNA binding
I8N71_RS08755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I8N71_RS08760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I8N71_RS08770	COG2257	FlhB HrpN YscU SpaS Family
I8N71_RS08775	COG0045	succinate-CoA ligase (ADP-forming) activity
I8N71_RS08780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I8N71_RS08785	COG0758	DNA mediated transformation
I8N71_RS08790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8N71_RS08795	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I8N71_RS08800	COG4974	Belongs to the 'phage' integrase family
I8N71_RS08805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I8N71_RS08810	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I8N71_RS08815	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I8N71_RS08820	COG1815	bacterial-type flagellum-dependent cell motility
I8N71_RS08825	COG1558	bacterial-type flagellum-dependent cell motility
I8N71_RS08830	COG1677	Flagellar hook-basal body complex protein FliE
I8N71_RS08840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N71_RS08845	COG1317	bacterial-type flagellum organization
I8N71_RS08850	COG1157	protein secretion by the type III secretion system
I8N71_RS08855	COG2882	bacterial-type flagellum organization
I8N71_RS08860	COG3334	PFAM MgtE intracellular
I8N71_RS08865	COG3144	bacterial-type flagellum assembly
I8N71_RS08870	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I8N71_RS08875	COG4786	Flagellar basal body rod
I8N71_RS08880	COG1582	Flagellar protein (FlbD)
I8N71_RS08885	COG1580	Controls the rotational direction of flagella during chemotaxis
I8N71_RS08890	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N71_RS08895	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N71_RS08895	COG1776	CheC inhibitor of MCP methylation
I8N71_RS08900	COG2201	protein-glutamate methylesterase activity
I8N71_RS08905	COG3190	flagellar
I8N71_RS08910	COG1338	Plays a role in the flagellum-specific transport system
I8N71_RS08915	COG1987	bacterial-type flagellum assembly
I8N71_RS08920	COG1684	flagellar biosynthetic protein fliR
I8N71_RS08925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8N71_RS08930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8N71_RS08935	COG1419	protein localization to endoplasmic reticulum
I8N71_RS08940	COG0455	bacterial-type flagellum organization
I8N71_RS08945	COG2201	protein-glutamate methylesterase activity
I8N71_RS08950	COG0643	Histidine kinase
I8N71_RS08950	COG2198	Histidine kinase
I8N71_RS08955	COG0835	chemotaxis
I8N71_RS08960	COG1776	CheC inhibitor of MCP methylation
I8N71_RS08965	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I8N71_RS08970	COG1191	sigma factor activity
I8N71_RS08980	COG0052	Belongs to the universal ribosomal protein uS2 family
I8N71_RS08985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I8N71_RS08990	COG0528	UMP kinase activity
I8N71_RS08995	COG0233	cytoplasmic translational termination
I8N71_RS09000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I8N71_RS09005	COG4589	Belongs to the CDS family
I8N71_RS09010	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I8N71_RS09015	COG0750	zinc metalloprotease
I8N71_RS09020	COG0442	prolyl-tRNA aminoacylation
I8N71_RS09025	COG2176	DNA-directed DNA polymerase activity
I8N71_RS09030	COG0779	Required for maturation of 30S ribosomal subunits
I8N71_RS09035	COG0195	Participates in both transcription termination and antitermination
I8N71_RS09040	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I8N71_RS09045	COG1358	cellular component organization or biogenesis
I8N71_RS09050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I8N71_RS09055	COG1550	Protein conserved in bacteria
I8N71_RS09060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I8N71_RS09065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I8N71_RS09070	COG0196	riboflavin kinase activity
I8N71_RS09075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I8N71_RS09080	COG1185	polyribonucleotide nucleotidyltransferase activity
I8N71_RS09085	COG0726	polysaccharide deacetylase
I8N71_RS09090	COG0612	Peptidase, M16
I8N71_RS09095	COG1873	PFAM PRC-barrel domain
I8N71_RS09100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I8N71_RS09105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8N71_RS09110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I8N71_RS09115	COG0527	aspartate kinase activity
I8N71_RS09120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I8N71_RS09125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8N71_RS09130	COG0740	serine-type endopeptidase activity
I8N71_RS09140	COG4980	gas vesicle protein
I8N71_RS09140	COG1674	ftsk spoiiie
I8N71_RS09145	COG2188	Transcriptional regulator
I8N71_RS09150	COG2814	Major facilitator Superfamily
I8N71_RS09155	COG0612	Peptidase, M16
I8N71_RS09160	COG0612	Peptidase, M16
I8N71_RS09165	COG0300	oxidoreductase activity
I8N71_RS09180	COG1426	Protein conserved in bacteria
I8N71_RS09185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I8N71_RS09190	COG1546	Belongs to the CinA family
I8N71_RS09190	COG1058	Belongs to the CinA family
I8N71_RS09195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I8N71_RS09200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N71_RS09205	COG1418	mRNA catabolic process
I8N71_RS09210	COG1692	metallophosphoesterase
I8N71_RS09215	COG2359	stage V sporulation protein S
I8N71_RS09220	COG1063	alcohol dehydrogenase
I8N71_RS09225	COG0156	8-amino-7-oxononanoate synthase activity
I8N71_RS09230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I8N71_RS09235	COG4550	Control of competence regulator ComK, YlbF/YmcA
I8N71_RS09245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I8N71_RS09250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I8N71_RS09265	COG3226	Transcriptional regulator
I8N71_RS09270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N71_RS09280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I8N71_RS09285	COG3321	synthase
I8N71_RS09290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I8N71_RS09290	COG2070	2-Nitropropane dioxygenase
I8N71_RS09295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N71_RS09300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8N71_RS09305	COG3425	synthase
I8N71_RS09310	COG1024	Enoyl-CoA hydratase
I8N71_RS09315	COG1024	Enoyl-CoA hydratase
I8N71_RS09320	COG0318	PFAM AMP-dependent synthetase and ligase
I8N71_RS09320	COG0300	oxidoreductase activity
I8N71_RS09320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS09320	COG3321	synthase
I8N71_RS09325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N71_RS09325	COG0300	oxidoreductase activity
I8N71_RS09325	COG4221	oxidoreductase activity
I8N71_RS09325	COG3321	synthase
I8N71_RS09330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N71_RS09330	COG3321	synthase
I8N71_RS09330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N71_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS09330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS09335	COG3321	synthase
I8N71_RS09335	COG4221	oxidoreductase activity
I8N71_RS09335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS09340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N71_RS09340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I8N71_RS09340	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8N71_RS09340	COG3321	synthase
I8N71_RS09345	COG2124	cytochrome p450
I8N71_RS09355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N71_RS09360	COG1404	Belongs to the peptidase S8 family
I8N71_RS09365	COG4195	phage-related replication protein
I8N71_RS09370	COG1764	response to oxidative stress
I8N71_RS09375	COG2076	Multidrug Resistance protein
I8N71_RS09380	COG2076	Multidrug Resistance protein
I8N71_RS09395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I8N71_RS09400	COG1923	regulation of RNA biosynthetic process
I8N71_RS09415	COG1780	Probably involved in ribonucleotide reductase function
I8N71_RS09420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N71_RS09425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N71_RS09430	COG4112	unkown
I8N71_RS09435	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS09440	COG0464	growth
I8N71_RS09445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I8N71_RS09450	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I8N71_RS09455	COG0789	Transcriptional regulator
I8N71_RS09460	COG0174	glutamine synthetase
I8N71_RS09480	COG4282	regulation of fungal-type cell wall biogenesis
I8N71_RS09490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N71_RS09520	COG0135	phosphoribosylanthranilate isomerase activity
I8N71_RS09525	COG2211	Major facilitator Superfamily
I8N71_RS09530	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N71_RS09535	COG1940	carbohydrate kinase activity
I8N71_RS09540	COG2115	Belongs to the xylose isomerase family
I8N71_RS09545	COG1070	Carbohydrate kinase
I8N71_RS09555	COG1525	nuclease
I8N71_RS09560	COG2814	Major facilitator Superfamily
I8N71_RS09565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8N71_RS09575	COG0756	dUTP diphosphatase activity
I8N71_RS09590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I8N71_RS09615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8N71_RS09630	COG3832	glyoxalase III activity
I8N71_RS09640	COG0697	spore germination
I8N71_RS09645	COG0531	amino acid
I8N71_RS09675	COG4195	phage-related replication protein
I8N71_RS09685	COG0346	lactoylglutathione lyase activity
I8N71_RS09690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I8N71_RS09695	COG1388	LysM domain
I8N71_RS09700	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N71_RS09705	COG4224	UPF0291 protein
I8N71_RS09710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I8N71_RS09720	COG3763	UPF0154 protein
I8N71_RS09730	COG0785	Cytochrome C biogenesis protein
I8N71_RS09735	COG2201	protein-glutamate methylesterase activity
I8N71_RS09740	COG4846	Membrane protein involved in cytochrome C biogenesis
I8N71_RS09750	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N71_RS09765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I8N71_RS09770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS09790	COG0824	Thioesterase
I8N71_RS09800	COG4841	protein insertion into membrane
I8N71_RS09805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I8N71_RS09810	COG1832	CoA-binding protein
I8N71_RS09815	COG0187	DNA topoisomerase II activity
I8N71_RS09820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8N71_RS09830	COG1115	amino acid carrier protein
I8N71_RS09835	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I8N71_RS09845	COG5520	Belongs to the glycosyl hydrolase 30 family
I8N71_RS09850	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N71_RS09855	COG2246	polysaccharide biosynthetic process
I8N71_RS09860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N71_RS09865	COG0586	Pfam SNARE associated Golgi protein
I8N71_RS09870	COG2404	hydrolase activity, acting on ester bonds
I8N71_RS09875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8N71_RS09880	COG1024	Enoyl-CoA hydratase
I8N71_RS09885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8N71_RS09890	COG0511	ligase activity, forming carbon-carbon bonds
I8N71_RS09895	COG0439	Biotin carboxylase
I8N71_RS09900	COG0318	PFAM AMP-dependent synthetase and ligase
I8N71_RS09905	COG1960	acyl-CoA dehydrogenase activity
I8N71_RS09920	COG1649	PFAM Uncharacterised BCR, COG1649
I8N71_RS09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS09930	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8N71_RS09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS09940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS09945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS09950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS09955	COG2027	D-alanyl-D-alanine carboxypeptidase
I8N71_RS09960	COG2017	converts alpha-aldose to the beta-anomer
I8N71_RS09965	COG0534	Mate efflux family protein
I8N71_RS09980	COG0582	viral genome integration into host DNA
I8N71_RS09985	COG0166	Belongs to the GPI family
I8N71_RS09990	COG0405	Gamma-glutamyltransferase
I8N71_RS09995	COG0583	DNA-binding transcription factor activity
I8N71_RS10000	COG0604	alcohol dehydrogenase
I8N71_RS10005	COG0493	'glutamate synthase
I8N71_RS10010	COG0067	glutamate synthase
I8N71_RS10010	COG0070	glutamate synthase
I8N71_RS10010	COG0069	glutamate synthase activity
I8N71_RS10015	COG0583	DNA-binding transcription factor activity
I8N71_RS10020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8N71_RS10025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N71_RS10035	COG0300	oxidoreductase activity
I8N71_RS10040	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I8N71_RS10050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N71_RS10055	COG2814	Major facilitator Superfamily
I8N71_RS10060	COG1070	Carbohydrate kinase
I8N71_RS10065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8N71_RS10070	COG0243	molybdopterin cofactor binding
I8N71_RS10100	COG0840	transmembrane signaling receptor activity
I8N71_RS10100	COG5278	phosphoserine phosphatase activity
I8N71_RS10105	COG2368	4-hydroxyphenylacetate
I8N71_RS10110	COG4305	rare lipoprotein A
I8N71_RS10115	COG3619	membrane
I8N71_RS10120	COG3866	Pectate lyase
I8N71_RS10125	COG2135	peptidase activity
I8N71_RS10135	COG2140	Oxalate decarboxylase
I8N71_RS10150	COG0456	acetyltransferase
I8N71_RS10170	COG2720	vancomycin resistance protein
I8N71_RS10180	COG3655	Transcriptional regulator
I8N71_RS10185	COG3739	integral membrane protein
I8N71_RS10190	COG0583	DNA-binding transcription factor activity
I8N71_RS10195	COG0697	spore germination
I8N71_RS10205	COG0693	protein deglycase activity
I8N71_RS10210	COG2367	Beta-lactamase
I8N71_RS10230	COG3848	Pyruvate phosphate dikinase
I8N71_RS10230	COG0574	Belongs to the PEP-utilizing enzyme family
I8N71_RS10235	COG0726	polysaccharide deacetylase
I8N71_RS10240	COG2314	TM2 domain
I8N71_RS10245	COG1396	sequence-specific DNA binding
I8N71_RS10260	COG2135	peptidase activity
I8N71_RS10300	COG0457	Tetratricopeptide repeat
I8N71_RS10325	COG5290	Psort location Cytoplasmic, score
I8N71_RS10350	COG5444	nuclease activity
I8N71_RS10355	COG4282	regulation of fungal-type cell wall biogenesis
I8N71_RS10360	COG1231	oxidoreductase activity
I8N71_RS10365	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N71_RS10370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N71_RS10375	COG2207	Transcriptional regulator
I8N71_RS10375	COG0662	Cupin 2, conserved barrel domain protein
I8N71_RS10380	COG0456	acetyltransferase
I8N71_RS10385	COG1309	transcriptional regulator
I8N71_RS10390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N71_RS10395	COG3708	Transcriptional regulator
I8N71_RS10400	COG2378	regulation of single-species biofilm formation
I8N71_RS10410	COG0640	Transcriptional regulator
I8N71_RS10415	COG0741	lytic transglycosylase activity
I8N71_RS10420	COG2322	membrane
I8N71_RS10435	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8N71_RS10440	COG3239	Fatty acid desaturase
I8N71_RS10445	COG4585	Histidine kinase
I8N71_RS10450	COG2197	response regulator
I8N71_RS10455	COG1388	LysM domain
I8N71_RS10455	COG3584	3D domain protein
I8N71_RS10460	COG0514	ATP-dependent DNA helicase (RecQ)
I8N71_RS10470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8N71_RS10475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N71_RS10490	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N71_RS10515	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS10520	COG1657	PFAM Prenyltransferase squalene oxidase
I8N71_RS10525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8N71_RS10530	COG0733	neurotransmitter:sodium symporter activity
I8N71_RS10535	COG0385	Bile acid
I8N71_RS10540	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N71_RS10545	COG0567	Dehydrogenase, E1 component
I8N71_RS10550	COG4548	von Willebrand factor, type A
I8N71_RS10555	COG0714	Associated with various cellular activities
I8N71_RS10560	COG2032	superoxide dismutase activity
I8N71_RS10565	COG1388	LysM domain
I8N71_RS10565	COG0791	NLP P60 protein
I8N71_RS10570	COG1819	glycosyl
I8N71_RS10575	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I8N71_RS10580	COG0534	Mate efflux family protein
I8N71_RS10585	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N71_RS10590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N71_RS10595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N71_RS10605	COG2962	Rard protein
I8N71_RS10620	COG2610	gluconate transmembrane transporter activity
I8N71_RS10625	COG1942	4-Oxalocrotonate Tautomerase
I8N71_RS10630	COG1733	regulation of RNA biosynthetic process
I8N71_RS10635	COG0778	Nitroreductase
I8N71_RS10640	COG0400	carboxylic ester hydrolase activity
I8N71_RS10645	COG0346	lactoylglutathione lyase activity
I8N71_RS10655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N71_RS10660	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS10660	COG0793	Belongs to the peptidase S41A family
I8N71_RS10665	COG2226	methyltransferase
I8N71_RS10675	COG1876	peptidase activity
I8N71_RS10680	COG0813	purine-nucleoside phosphorylase activity
I8N71_RS10695	COG0671	phosphoesterase, PA-phosphatase related
I8N71_RS10715	COG4479	Belongs to the UPF0346 family
I8N71_RS10725	COG1509	lysine 2,3-aminomutase activity
I8N71_RS10730	COG0456	acetyltransferase
I8N71_RS10735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N71_RS10740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8N71_RS10745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8N71_RS10750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N71_RS10765	COG0456	acetyltransferase
I8N71_RS10770	COG0463	Glycosyl transferase, family 2
I8N71_RS10785	COG4641	Protein conserved in bacteria
I8N71_RS10790	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
I8N71_RS10795	COG1086	Polysaccharide biosynthesis protein
I8N71_RS10805	COG3331	DNA recombination
I8N71_RS10860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8N71_RS10895	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I8N71_RS10900	COG0756	dUTP diphosphatase activity
I8N71_RS10905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS10925	COG1372	Participates in initiation and elongation during chromosome replication
I8N71_RS10925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N71_RS10930	COG1372	Participates in initiation and elongation during chromosome replication
I8N71_RS10930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N71_RS10935	COG1780	Probably involved in ribonucleotide reductase function
I8N71_RS11025	COG0270	DNA (cytosine-5-)-methyltransferase activity
I8N71_RS11035	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I8N71_RS11040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I8N71_RS11065	COG3584	3D domain protein
I8N71_RS11070	COG0587	DNA-directed DNA polymerase activity
I8N71_RS11075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I8N71_RS11080	COG0358	DNA primase activity
I8N71_RS11085	COG0305	Participates in initiation and elongation during chromosome replication
I8N71_RS11095	COG2887	Belongs to the helicase family. UvrD subfamily
I8N71_RS11125	COG3420	alginic acid biosynthetic process
I8N71_RS11125	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N71_RS11130	COG4195	phage-related replication protein
I8N71_RS11145	COG2135	peptidase activity
I8N71_RS11150	COG1793	dna ligase
I8N71_RS11205	COG4474	Belongs to the UPF0398 family
I8N71_RS11215	COG1388	LysM domain
I8N71_RS11235	COG3646	Phage regulatory protein
I8N71_RS11235	COG3645	SOS response
I8N71_RS11290	COG3655	Transcriptional regulator
I8N71_RS11305	COG0582	viral genome integration into host DNA
I8N71_RS11385	COG3655	Transcriptional regulator
I8N71_RS11425	COG1395	domain, Protein
I8N71_RS11440	COG0776	regulation of translation
I8N71_RS11475	COG4373	Mu-like prophage FluMu protein gp28
I8N71_RS11575	COG0582	viral genome integration into host DNA
I8N71_RS11605	COG0739	heme binding
I8N71_RS11605	COG0741	lytic transglycosylase activity
I8N71_RS11605	COG1196	nuclear chromosome segregation
I8N71_RS11615	COG2433	Pfam Transposase IS66
I8N71_RS11625	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N71_RS11625	COG4632	Exopolysaccharide biosynthesis protein
I8N71_RS11640	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS11655	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I8N71_RS11660	COG0463	Glycosyl transferase, family 2
I8N71_RS11665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS11670	COG3271	cysteine-type peptidase activity
I8N71_RS11670	COG2274	protein secretion by the type I secretion system
I8N71_RS11685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8N71_RS11715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N71_RS11730	COG5444	nuclease activity
I8N71_RS11735	COG4282	regulation of fungal-type cell wall biogenesis
I8N71_RS11750	COG1525	nuclease
I8N71_RS11760	COG2746	aminoglycoside 3-N-acetyltransferase activity
I8N71_RS11785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N71_RS11790	COG1086	Polysaccharide biosynthesis protein
I8N71_RS11795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I8N71_RS11800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I8N71_RS11805	COG1846	Transcriptional regulator
I8N71_RS11810	COG0534	Mate efflux family protein
I8N71_RS11820	COG4698	Protein conserved in bacteria
I8N71_RS11825	COG2755	lipolytic protein G-D-S-L family
I8N71_RS11830	COG1999	signal sequence binding
I8N71_RS11840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8N71_RS11845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I8N71_RS11850	COG1272	protein, Hemolysin III
I8N71_RS11855	COG0204	Acyl-transferase
I8N71_RS11860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N71_RS11865	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I8N71_RS11870	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I8N71_RS11880	COG2521	methyltransferase
I8N71_RS11880	COG2136	Putative SAM-dependent methyltransferase
I8N71_RS11890	COG0129	dihydroxy-acid dehydratase activity
I8N71_RS11895	COG1413	lyase activity
I8N71_RS11900	COG1418	mRNA catabolic process
I8N71_RS11905	COG0386	Belongs to the glutathione peroxidase family
I8N71_RS11910	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I8N71_RS11915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I8N71_RS11925	COG1278	Cold shock
I8N71_RS11945	COG0328	RNA-DNA hybrid ribonuclease activity
I8N71_RS11950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I8N71_RS11955	COG0328	RNA-DNA hybrid ribonuclease activity
I8N71_RS11965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N71_RS11980	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I8N71_RS11990	COG1755	Isoprenylcysteine carboxyl methyltransferase
I8N71_RS11995	COG3424	synthase
I8N71_RS12000	COG2233	PERMEase
I8N71_RS12005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I8N71_RS12010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I8N71_RS12020	COG0800	Aldolase
I8N71_RS12025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N71_RS12030	COG1609	Transcriptional regulator
I8N71_RS12035	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I8N71_RS12040	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS12045	COG1199	ATP-dependent helicase activity
I8N71_RS12060	COG0116	Belongs to the methyltransferase superfamily
I8N71_RS12075	COG4474	Belongs to the UPF0398 family
I8N71_RS12090	COG3359	exonuclease
I8N71_RS12095	COG1111	helicase
I8N71_RS12095	COG1205	dead DEAH box helicase
I8N71_RS12100	COG2190	(PTS) system
I8N71_RS12105	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N71_RS12140	COG3331	DNA recombination
I8N71_RS12145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N71_RS12145	COG4499	WXG100 protein secretion system (Wss), protein YukC
I8N71_RS12155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I8N71_RS12160	COG3935	DnaD domain protein
I8N71_RS12165	COG0017	Asparaginyl-tRNA synthetase
I8N71_RS12170	COG0436	Aminotransferase
I8N71_RS12175	COG5353	protein conserved in bacteria
I8N71_RS12185	COG1199	ATP-dependent helicase activity
I8N71_RS12185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I8N71_RS12190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I8N71_RS12195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I8N71_RS12200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I8N71_RS12205	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I8N71_RS12205	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I8N71_RS12210	COG0617	tRNA 3'-terminal CCA addition
I8N71_RS12215	COG0438	transferase activity, transferring glycosyl groups
I8N71_RS12220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N71_RS12225	COG1803	Methylglyoxal synthase
I8N71_RS12230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I8N71_RS12235	COG1694	Mazg nucleotide pyrophosphohydrolase
I8N71_RS12240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N71_RS12250	COG4347	Protein of unknown function (DUF1405)
I8N71_RS12255	COG2010	Cytochrome c
I8N71_RS12255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8N71_RS12260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8N71_RS12265	COG0723	plastoquinol--plastocyanin reductase activity
I8N71_RS12275	COG5582	Belongs to the UPF0302 family
I8N71_RS12280	COG0457	Tetratricopeptide repeat
I8N71_RS12285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I8N71_RS12290	COG0287	Prephenate dehydrogenase
I8N71_RS12295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I8N71_RS12300	COG0159	tryptophan synthase activity
I8N71_RS12305	COG0133	tryptophan synthase activity
I8N71_RS12310	COG0135	phosphoribosylanthranilate isomerase activity
I8N71_RS12320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I8N71_RS12325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8N71_RS12330	COG4401	Chorismate mutase type I
I8N71_RS12335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I8N71_RS12340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I8N71_RS12345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I8N71_RS12350	COG0105	UTP biosynthetic process
I8N71_RS12355	COG0142	geranyltranstransferase activity
I8N71_RS12360	COG2226	methyltransferase
I8N71_RS12365	COG0142	geranyltranstransferase activity
I8N71_RS12375	COG0302	gtp cyclohydrolase
I8N71_RS12380	COG0776	regulation of translation
I8N71_RS12385	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I8N71_RS12400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I8N71_RS12405	COG1160	GTP binding
I8N71_RS12430	COG1304	FMN binding
I8N71_RS12435	COG0539	negative regulation of cytoplasmic translation
I8N71_RS12440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I8N71_RS12450	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I8N71_RS12455	COG2959	enzyme of heme biosynthesis
I8N71_RS12460	COG3773	Cell wall hydrolase
I8N71_RS12460	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS12465	COG2339	peptidase activity
I8N71_RS12470	COG0492	ferredoxin-NADP+ reductase activity
I8N71_RS12475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N71_RS12480	COG4862	establishment of competence for transformation
I8N71_RS12485	COG1408	metallophosphoesterase
I8N71_RS12495	COG1388	LysM domain
I8N71_RS12500	COG1266	CAAX protease self-immunity
I8N71_RS12505	COG0514	ATP-dependent DNA helicase (RecQ)
I8N71_RS12510	COG4955	Helix-turn-helix domain
I8N71_RS12515	COG1141	Ferredoxin
I8N71_RS12520	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I8N71_RS12525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8N71_RS12530	COG0710	3-dehydroquinate dehydratase activity
I8N71_RS12540	COG1595	DNA-templated transcription, initiation
I8N71_RS12545	COG5002	protein histidine kinase activity
I8N71_RS12550	COG0745	RESPONSE REGULATOR receiver
I8N71_RS12555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8N71_RS12560	COG1333	cytochrome c biogenesis protein
I8N71_RS12565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS12570	COG1187	pseudouridine synthase activity
I8N71_RS12575	COG0700	Nucleoside recognition
I8N71_RS12580	COG2715	membrane protein required for spore maturation
I8N71_RS12585	COG1686	Belongs to the peptidase S11 family
I8N71_RS12595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I8N71_RS12600	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I8N71_RS12610	COG0456	acetyltransferase
I8N71_RS12615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I8N71_RS12620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I8N71_RS12620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I8N71_RS12625	COG0307	riboflavin synthase, alpha
I8N71_RS12630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8N71_RS12630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8N71_RS12640	COG0681	Belongs to the peptidase S26 family
I8N71_RS12650	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I8N71_RS12665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I8N71_RS12670	COG4086	secreted protein
I8N71_RS12675	COG0019	diaminopimelate decarboxylase activity
I8N71_RS12680	COG0697	spore germination
I8N71_RS12695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N71_RS12715	COG1191	sigma factor activity
I8N71_RS12720	COG2172	sigma factor antagonist activity
I8N71_RS12725	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N71_RS12730	COG1686	Belongs to the peptidase S11 family
I8N71_RS12735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I8N71_RS12740	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I8N71_RS12745	COG4974	Belongs to the 'phage' integrase family
I8N71_RS12755	COG0735	belongs to the Fur family
I8N71_RS12760	COG1300	Membrane
I8N71_RS12770	COG0281	malic enzyme
I8N71_RS12775	COG1757	Na H antiporter
I8N71_RS12780	COG1027	Aspartate ammonia-lyase
I8N71_RS12785	COG0252	asparaginase activity
I8N71_RS12790	COG1396	sequence-specific DNA binding
I8N71_RS12795	COG1379	DNA repair
I8N71_RS12800	COG0494	nUDIX hydrolase
I8N71_RS12810	COG0667	Aldo Keto reductase
I8N71_RS12820	COG1073	alpha beta
I8N71_RS12830	COG4918	Iron-sulphur cluster biosynthesis
I8N71_RS12835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I8N71_RS12835	COG0456	acetyltransferase
I8N71_RS12840	COG2329	Antibiotic biosynthesis monooxygenase
I8N71_RS12845	COG0456	acetyltransferase
I8N71_RS12855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8N71_RS12865	COG2211	Major facilitator Superfamily
I8N71_RS12875	COG0346	lactoylglutathione lyase activity
I8N71_RS12880	COG1072	(Pantothenic acid kinase))
I8N71_RS12885	COG3048	D-serine ammonia-lyase activity
I8N71_RS12890	COG0300	oxidoreductase activity
I8N71_RS12895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N71_RS12900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N71_RS12905	COG4187	Peptidase family M20/M25/M40
I8N71_RS12910	COG1902	pentaerythritol trinitrate reductase activity
I8N71_RS12915	COG0596	Alpha beta hydrolase
I8N71_RS12925	COG1234	tRNA 3'-trailer cleavage
I8N71_RS12930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I8N71_RS12935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I8N71_RS12940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8N71_RS12950	COG0706	membrane insertase activity
I8N71_RS12955	COG3361	conserved protein (COG2071)
I8N71_RS12960	COG2195	Cleaves the N-terminal amino acid of tripeptides
I8N71_RS12965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8N71_RS12970	COG0346	lactoylglutathione lyase activity
I8N71_RS12980	COG1376	ErfK ybiS ycfS ynhG family protein
I8N71_RS12985	COG4129	membrane
I8N71_RS12990	COG1126	abc transporter atp-binding protein
I8N71_RS12995	COG0765	amino acid transport
I8N71_RS13000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N71_RS13010	COG1597	lipid kinase activity
I8N71_RS13015	COG2814	Major facilitator Superfamily
I8N71_RS13020	COG4978	Transcriptional regulator
I8N71_RS13020	COG0789	Transcriptional regulator
I8N71_RS13025	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N71_RS13030	COG0022	dehydrogenase e1 component
I8N71_RS13035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N71_RS13040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N71_RS13045	COG3426	butyrate kinase activity
I8N71_RS13050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N71_RS13055	COG0280	phosphate acetyltransferase
I8N71_RS13060	COG3829	transcription factor binding
I8N71_RS13060	COG3290	protein histidine kinase activity
I8N71_RS13070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I8N71_RS13075	COG2079	MmgE PrpD family protein
I8N71_RS13080	COG0372	Belongs to the citrate synthase family
I8N71_RS13085	COG1960	acyl-CoA dehydrogenase activity
I8N71_RS13090	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8N71_RS13095	COG0183	Belongs to the thiolase family
I8N71_RS13100	COG0584	glycerophosphoryl diester phosphodiesterase
I8N71_RS13105	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS13120	COG1902	pentaerythritol trinitrate reductase activity
I8N71_RS13125	COG0745	RESPONSE REGULATOR receiver
I8N71_RS13130	COG0750	zinc metalloprotease
I8N71_RS13135	COG0497	DNA recombination
I8N71_RS13140	COG1438	arginine binding
I8N71_RS13145	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I8N71_RS13150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I8N71_RS13155	COG0142	geranyltranstransferase activity
I8N71_RS13160	COG1722	exodeoxyribonuclease VII activity
I8N71_RS13165	COG1570	exodeoxyribonuclease VII activity
I8N71_RS13170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I8N71_RS13175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I8N71_RS13180	COG1302	Protein conserved in bacteria
I8N71_RS13185	COG0439	Biotin carboxylase
I8N71_RS13190	COG0511	ligase activity, forming carbon-carbon bonds
I8N71_RS13230	COG3854	ATPases associated with a variety of cellular activities
I8N71_RS13240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I8N71_RS13245	COG0006	proline dipeptidase activity
I8N71_RS13250	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I8N71_RS13260	COG3872	metal-dependent enzyme
I8N71_RS13270	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8N71_RS13275	COG1321	iron dependent repressor
I8N71_RS13280	COG0095	Lipoate-protein ligase
I8N71_RS13285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N71_RS13290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I8N71_RS13295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I8N71_RS13300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I8N71_RS13305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8N71_RS13320	COG1396	sequence-specific DNA binding
I8N71_RS13330	COG0681	Belongs to the peptidase S26 family
I8N71_RS13355	COG4940	Competence protein ComGF
I8N71_RS13365	COG4970	Tfp pilus assembly protein FimT
I8N71_RS13370	COG4537	Required for transformation and DNA binding
I8N71_RS13375	COG1459	type II secretion system
I8N71_RS13380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I8N71_RS13385	COG0598	Magnesium transport protein CorA
I8N71_RS13390	COG1253	flavin adenine dinucleotide binding
I8N71_RS13395	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N71_RS13405	COG1393	Belongs to the ArsC family
I8N71_RS13415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N71_RS13425	COG0011	TIGRFAM Protein of
I8N71_RS13435	COG2866	Carboxypeptidase
I8N71_RS13440	COG1368	sulfuric ester hydrolase activity
I8N71_RS13445	COG1940	carbohydrate kinase activity
I8N71_RS13450	COG4483	Protein conserved in bacteria
I8N71_RS13455	COG0705	Rhomboid family
I8N71_RS13455	COG0457	Tetratricopeptide repeat
I8N71_RS13465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I8N71_RS13475	COG0438	transferase activity, transferring glycosyl groups
I8N71_RS13490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8N71_RS13495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N71_RS13500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N71_RS13505	COG0581	inorganic phosphate transmembrane transporter activity
I8N71_RS13510	COG0573	inorganic phosphate transmembrane transporter activity
I8N71_RS13515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I8N71_RS13520	COG0768	penicillin binding
I8N71_RS13525	COG0477	Major facilitator Superfamily
I8N71_RS13530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8N71_RS13535	COG2839	Protein conserved in bacteria
I8N71_RS13540	COG5521	maltodextrose utilization protein MalA
I8N71_RS13550	COG1388	LysM domain
I8N71_RS13555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I8N71_RS13560	COG4709	membrane
I8N71_RS13565	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I8N71_RS13570	COG0735	belongs to the Fur family
I8N71_RS13575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N71_RS13585	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I8N71_RS13590	COG0513	Belongs to the DEAD box helicase family
I8N71_RS13600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I8N71_RS13605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I8N71_RS13610	COG2384	SAM-dependent methyltransferase
I8N71_RS13615	COG2010	Cytochrome c
I8N71_RS13620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I8N71_RS13625	COG0358	DNA primase activity
I8N71_RS13630	COG1671	Belongs to the UPF0178 family
I8N71_RS13635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I8N71_RS13640	COG0517	IMP dehydrogenase activity
I8N71_RS13645	COG0751	glycine-tRNA ligase activity
I8N71_RS13650	COG0752	glycyl-tRNA synthetase alpha subunit
I8N71_RS13655	COG1381	Involved in DNA repair and RecF pathway recombination
I8N71_RS13665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I8N71_RS13670	COG0295	cytidine deaminase activity
I8N71_RS13675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I8N71_RS13680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I8N71_RS13685	COG1480	7TM receptor with intracellular HD hydrolase
I8N71_RS13690	COG1702	phosphate starvation-inducible protein PhoH
I8N71_RS13695	COG0561	phosphatase activity
I8N71_RS13710	COG4864	UPF0365 protein
I8N71_RS13715	COG1030	water channel activity
I8N71_RS13720	COG1610	YqeY-like protein
I8N71_RS13730	COG1283	sodium-dependent phosphate transmembrane transporter activity
I8N71_RS13735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I8N71_RS13740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I8N71_RS13745	COG2264	protein methyltransferase activity
I8N71_RS13750	COG0484	heat shock protein binding
I8N71_RS13755	COG0443	Heat shock 70 kDa protein
I8N71_RS13760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I8N71_RS13765	COG1420	regulation of RNA biosynthetic process
I8N71_RS13770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8N71_RS13775	COG0481	GTPase activity
I8N71_RS13785	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS13790	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I8N71_RS13795	COG0268	Binds directly to 16S ribosomal RNA
I8N71_RS13800	COG1466	dna polymerase III delta subunit
I8N71_RS13815	COG0658	competence protein
I8N71_RS13815	COG2333	competence protein COMEC
I8N71_RS13820	COG2131	deaminase
I8N71_RS13825	COG1555	photosystem II stabilization
I8N71_RS13825	COG1596	polysaccharide export
I8N71_RS13830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N71_RS13835	COG2226	methyltransferase
I8N71_RS13840	COG0799	negative regulation of ribosome biogenesis
I8N71_RS13845	COG1713	HD superfamily hydrolase involved in NAD metabolism
I8N71_RS13850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I8N71_RS13855	COG1534	Rna-binding protein
I8N71_RS13860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I8N71_RS13865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I8N71_RS13870	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I8N71_RS13880	COG2755	lipolytic protein G-D-S-L family
I8N71_RS13885	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS13885	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS13890	COG0398	Pfam SNARE associated Golgi protein
I8N71_RS13895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I8N71_RS13905	COG3209	COG3209 Rhs family protein
I8N71_RS13915	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N71_RS13920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8N71_RS13925	COG0798	PFAM Bile acid sodium symporter
I8N71_RS13930	COG0346	lactoylglutathione lyase activity
I8N71_RS13935	COG0640	Transcriptional regulator
I8N71_RS13940	COG3403	YqcI/YcgG family
I8N71_RS13945	COG0457	Tetratricopeptide repeat
I8N71_RS13960	COG5444	nuclease activity
I8N71_RS13985	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS13985	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS13990	COG4824	toxin secretion phage lysis holin
I8N71_RS14020	COG3778	Protein conserved in bacteria
I8N71_RS14025	COG3299	homolog of phage Mu protein gp47
I8N71_RS14030	COG3628	GPW Gp25 family protein
I8N71_RS14040	COG4193	domain, Protein
I8N71_RS14045	COG1652	LysM domain
I8N71_RS14050	COG3953	SLT domain
I8N71_RS14050	COG5280	Phage tail tape measure protein TP901
I8N71_RS14115	COG4653	Phage capsid family
I8N71_RS14120	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I8N71_RS14130	COG2369	cell adhesion
I8N71_RS14135	COG5518	Phage portal protein
I8N71_RS14140	COG1783	phage Terminase large subunit
I8N71_RS14145	COG5484	DNA packaging
I8N71_RS14155	COG3677	Transposase
I8N71_RS14170	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I8N71_RS14180	COG1484	DNA-dependent DNA replication
I8N71_RS14185	COG3935	DnaD domain protein
I8N71_RS14190	COG3723	Recombinational DNA repair protein, rece pathway
I8N71_RS14195	COG5377	YqaJ viral recombinase family
I8N71_RS14225	COG1476	TRANSCRIPTIONal
I8N71_RS14230	COG3620	sequence-specific DNA binding
I8N71_RS14240	COG0563	adenylate kinase activity
I8N71_RS14245	COG2856	Zn peptidase
I8N71_RS14270	COG3223	Belongs to the PsiE family
I8N71_RS14275	COG5002	protein histidine kinase activity
I8N71_RS14275	COG0642	Histidine kinase
I8N71_RS14280	COG0745	RESPONSE REGULATOR receiver
I8N71_RS14285	COG2311	Membrane
I8N71_RS14295	COG0454	-acetyltransferase
I8N71_RS14300	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N71_RS14310	COG0730	response to heat
I8N71_RS14315	COG0425	Belongs to the sulfur carrier protein TusA family
I8N71_RS14320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N71_RS14320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N71_RS14330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N71_RS14330	COG0425	Belongs to the sulfur carrier protein TusA family
I8N71_RS14335	COG2210	Belongs to the sulfur carrier protein TusA family
I8N71_RS14340	COG1937	Protein conserved in bacteria
I8N71_RS14350	COG0662	Cupin 2, conserved barrel domain protein
I8N71_RS14360	COG4978	Transcriptional regulator
I8N71_RS14360	COG0789	Transcriptional regulator
I8N71_RS14365	COG2814	Major facilitator Superfamily
I8N71_RS14370	COG0456	acetyltransferase
I8N71_RS14375	COG1253	flavin adenine dinucleotide binding
I8N71_RS14385	COG0697	spore germination
I8N71_RS14390	COG0583	DNA-binding transcription factor activity
I8N71_RS14395	COG2072	flavoprotein involved in K transport
I8N71_RS14400	COG1230	cation diffusion facilitator family transporter
I8N71_RS14405	COG1942	4-Oxalocrotonate Tautomerase
I8N71_RS14410	COG0583	DNA-binding transcription factor activity
I8N71_RS14420	COG1114	Component of the transport system for branched-chain amino acids
I8N71_RS14425	COG1687	branched-chain amino acid
I8N71_RS14430	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I8N71_RS14435	COG1522	sequence-specific DNA binding
I8N71_RS14440	COG2732	(Barnase) inhibitor
I8N71_RS14445	COG2124	cytochrome p450
I8N71_RS14460	COG1335	isochorismatase
I8N71_RS14475	COG2318	DinB family
I8N71_RS14485	COG2070	2-Nitropropane dioxygenase
I8N71_RS14490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I8N71_RS14515	COG3443	Belongs to the bacterial solute-binding protein 9 family
I8N71_RS14520	COG1595	DNA-templated transcription, initiation
I8N71_RS14525	COG0667	Aldo Keto reductase
I8N71_RS14530	COG2851	Citrate transporter
I8N71_RS14535	COG0583	DNA-binding transcription factor activity
I8N71_RS14540	COG2828	Protein conserved in bacteria
I8N71_RS14545	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS14550	COG5566	PFAM Mor transcription activator
I8N71_RS14555	COG0596	Alpha beta hydrolase
I8N71_RS14560	COG4991	sh3 domain protein
I8N71_RS14565	COG4991	sh3 domain protein
I8N71_RS14575	COG0346	lactoylglutathione lyase activity
I8N71_RS14585	COG5577	PFAM Coat F domain
I8N71_RS14590	COG1063	alcohol dehydrogenase
I8N71_RS14600	COG5577	PFAM Coat F domain
I8N71_RS14605	COG0789	Transcriptional regulator
I8N71_RS14615	COG1064	alcohol dehydrogenase
I8N71_RS14620	COG0693	protein deglycase activity
I8N71_RS14625	COG1621	beta-fructofuranosidase activity
I8N71_RS14630	COG3716	PTS system mannose fructose sorbose family IID component
I8N71_RS14635	COG3715	PTS system
I8N71_RS14640	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS14645	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N71_RS14650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I8N71_RS14650	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I8N71_RS14660	COG1113	amino acid transport
I8N71_RS14665	COG1280	lysine exporter protein (LysE YggA)
I8N71_RS14670	COG1378	Sugar-specific transcriptional regulator TrmB
I8N71_RS14675	COG1595	DNA-templated transcription, initiation
I8N71_RS14685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I8N71_RS14685	COG2755	lipolytic protein G-D-S-L family
I8N71_RS14695	COG2124	cytochrome p450
I8N71_RS14695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N71_RS14700	COG1309	transcriptional regulator
I8N71_RS14705	COG2226	methyltransferase
I8N71_RS14720	COG2116	formate transmembrane transporter activity
I8N71_RS14725	COG5609	conserved protein (DUF2294)
I8N71_RS14730	COG3383	formate dehydrogenase (NAD+) activity
I8N71_RS14735	COG2427	Protein of unknown function (DUF1641)
I8N71_RS14745	COG0626	cystathionine gamma-synthase activity
I8N71_RS14750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N71_RS14755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I8N71_RS14760	COG2226	methyltransferase
I8N71_RS14775	COG0768	penicillin binding
I8N71_RS14780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I8N71_RS14785	COG0572	uridine kinase
I8N71_RS14790	COG0826	peptidase U32
I8N71_RS14795	COG0826	peptidase U32
I8N71_RS14800	COG4122	O-methyltransferase activity
I8N71_RS14805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8N71_RS14810	COG3906	Belongs to the UPF0473 family
I8N71_RS14815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I8N71_RS14820	COG4472	Bacterial protein of unknown function (DUF965)
I8N71_RS14825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I8N71_RS14830	COG0628	permease
I8N71_RS14835	COG1126	abc transporter atp-binding protein
I8N71_RS14840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N71_RS14845	COG0765	amino acid transport
I8N71_RS14850	COG0765	amino acid transport
I8N71_RS14865	COG3881	PFAM PRC-barrel domain
I8N71_RS14870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8N71_RS14875	COG0457	Tetratricopeptide repeat
I8N71_RS14880	COG0482	sulfurtransferase activity
I8N71_RS14885	COG1104	cysteine desulfurase activity
I8N71_RS14890	COG1959	2 iron, 2 sulfur cluster binding
I8N71_RS14895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I8N71_RS14900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I8N71_RS14910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I8N71_RS14915	COG0124	histidyl-tRNA synthetase
I8N71_RS14925	COG3103	Sh3 type 3 domain protein
I8N71_RS14925	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS14925	COG4991	sh3 domain protein
I8N71_RS14930	COG1490	D-aminoacyl-tRNA deacylase activity
I8N71_RS14935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I8N71_RS14940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I8N71_RS14945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I8N71_RS14945	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I8N71_RS14950	COG5416	Lipopolysaccharide assembly protein A domain
I8N71_RS14955	COG0490	domain, Protein
I8N71_RS14960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8N71_RS14960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8N71_RS14970	COG2244	polysaccharide biosynthetic process
I8N71_RS14975	COG2323	membrane
I8N71_RS14985	COG1862	Preprotein translocase
I8N71_RS14990	COG0343	queuine tRNA-ribosyltransferase activity
I8N71_RS14995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I8N71_RS15005	COG2255	four-way junction helicase activity
I8N71_RS15010	COG0632	four-way junction helicase activity
I8N71_RS15020	COG2814	Major facilitator Superfamily
I8N71_RS15025	COG0673	inositol 2-dehydrogenase activity
I8N71_RS15030	COG2112	serine threonine protein kinase
I8N71_RS15050	COG1115	amino acid carrier protein
I8N71_RS15055	COG0217	transcriptional regulatory protein
I8N71_RS15065	COG1388	LysM domain
I8N71_RS15070	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I8N71_RS15075	COG0157	Belongs to the NadC ModD family
I8N71_RS15080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I8N71_RS15085	COG1104	cysteine desulfurase activity
I8N71_RS15090	COG1827	regulation of RNA biosynthetic process
I8N71_RS15095	COG0077	Prephenate dehydratase
I8N71_RS15100	COG4492	Belongs to the UPF0735 family
I8N71_RS15105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I8N71_RS15110	COG3290	protein histidine kinase activity
I8N71_RS15120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I8N71_RS15125	COG2868	ribosomal protein
I8N71_RS15130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I8N71_RS15135	COG1994	Peptidase M50
I8N71_RS15140	COG0739	heme binding
I8N71_RS15145	COG2894	cell division
I8N71_RS15150	COG0850	regulation of cytokinetic process
I8N71_RS15155	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I8N71_RS15165	COG1077	Cell shape determining protein MreB Mrl
I8N71_RS15170	COG2003	Belongs to the UPF0758 family
I8N71_RS15175	COG0424	maF-like protein
I8N71_RS15185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I8N71_RS15190	COG0285	dihydrofolate synthase activity
I8N71_RS15195	COG0525	valine-tRNA ligase activity
I8N71_RS15205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N71_RS15210	COG1388	LysM domain
I8N71_RS15215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I8N71_RS15220	COG0113	porphobilinogen synthase activity
I8N71_RS15225	COG1587	Uroporphyrinogen-III synthase
I8N71_RS15230	COG0181	hydroxymethylbilane synthase activity
I8N71_RS15235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8N71_RS15240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I8N71_RS15250	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I8N71_RS15255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I8N71_RS15260	COG1067	ATP-dependent peptidase activity
I8N71_RS15260	COG0470	DNA polymerase III
I8N71_RS15265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I8N71_RS15270	COG0544	peptidyl-prolyl cis-trans isomerase activity
I8N71_RS15275	COG1477	protein flavinylation
I8N71_RS15275	COG0457	Tetratricopeptide repeat
I8N71_RS15280	COG0066	3-isopropylmalate dehydratase activity
I8N71_RS15285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I8N71_RS15290	COG0473	3-isopropylmalate dehydrogenase activity
I8N71_RS15295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8N71_RS15300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I8N71_RS15305	COG0440	acetolactate synthase activity
I8N71_RS15310	COG0028	Belongs to the TPP enzyme family
I8N71_RS15320	COG0454	-acetyltransferase
I8N71_RS15325	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I8N71_RS15335	COG0622	Phosphoesterase
I8N71_RS15340	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I8N71_RS15345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I8N71_RS15350	COG5401	PFAM Sporulation and spore germination
I8N71_RS15355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I8N71_RS15360	COG1846	Transcriptional regulator
I8N71_RS15365	COG2197	response regulator
I8N71_RS15370	COG0824	Thioesterase
I8N71_RS15375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I8N71_RS15380	COG1053	succinate dehydrogenase
I8N71_RS15385	COG2009	succinate dehydrogenase
I8N71_RS15390	COG1719	4-vinyl reductase, 4VR
I8N71_RS15395	COG0527	aspartate kinase activity
I8N71_RS15400	COG0322	excinuclease ABC activity
I8N71_RS15405	COG3118	belongs to the thioredoxin family
I8N71_RS15415	COG3534	alpha-L-arabinofuranosidase
I8N71_RS15420	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I8N71_RS15425	COG2086	electron transfer activity
I8N71_RS15430	COG1024	Enoyl-CoA hydratase
I8N71_RS15435	COG1309	transcriptional regulator
I8N71_RS15440	COG0318	PFAM AMP-dependent synthetase and ligase
I8N71_RS15445	COG3766	membrane
I8N71_RS15450	COG1193	negative regulation of DNA recombination
I8N71_RS15455	COG1796	DNA polymerase
I8N71_RS15455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I8N71_RS15460	COG1286	toxin biosynthetic process
I8N71_RS15465	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I8N71_RS15470	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I8N71_RS15475	COG0072	phenylalanine-tRNA ligase activity
I8N71_RS15475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N71_RS15480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I8N71_RS15490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8N71_RS15500	COG3835	regulator
I8N71_RS15505	COG0277	FAD linked oxidase domain protein
I8N71_RS15510	COG0247	lactate metabolic process
I8N71_RS15515	COG0346	lactoylglutathione lyase activity
I8N71_RS15525	COG1966	Carbon starvation protein
I8N71_RS15530	COG3534	alpha-L-arabinofuranosidase
I8N71_RS15535	COG0395	ABC-type sugar transport system, permease component
I8N71_RS15540	COG1175	transmembrane transport
I8N71_RS15545	COG1653	transport
I8N71_RS15550	COG0371	Dehydrogenase
I8N71_RS15555	COG0647	UMP catabolic process
I8N71_RS15560	COG0235	Class ii aldolase
I8N71_RS15565	COG1069	ribulokinase activity
I8N71_RS15570	COG2160	L-arabinose isomerase activity
I8N71_RS15575	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N71_RS15580	COG1363	Peptidase, m42
I8N71_RS15590	COG3326	Membrane
I8N71_RS15595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I8N71_RS15600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I8N71_RS15605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I8N71_RS15615	COG1346	cytolysis
I8N71_RS15620	COG1380	Effector of murein hydrolase LrgA
I8N71_RS15625	COG3279	Response regulator of the LytR AlgR family
I8N71_RS15630	COG3275	phosphorelay sensor kinase activity
I8N71_RS15635	COG1011	Hydrolase
I8N71_RS15640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I8N71_RS15650	COG0398	Pfam SNARE associated Golgi protein
I8N71_RS15655	COG1484	DNA-dependent DNA replication
I8N71_RS15660	COG3611	Membrane attachment protein
I8N71_RS15665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I8N71_RS15670	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I8N71_RS15675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8N71_RS15680	COG1733	regulation of RNA biosynthetic process
I8N71_RS15685	COG2814	Major facilitator Superfamily
I8N71_RS15690	COG0656	L-ascorbic acid biosynthetic process
I8N71_RS15695	COG0237	dephospho-CoA kinase activity
I8N71_RS15700	COG1971	Probably functions as a manganese efflux pump
I8N71_RS15705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8N71_RS15710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N71_RS15710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N71_RS15715	COG5002	protein histidine kinase activity
I8N71_RS15720	COG0745	RESPONSE REGULATOR receiver
I8N71_RS15725	COG0039	L-malate dehydrogenase activity
I8N71_RS15730	COG0538	isocitrate dehydrogenase activity
I8N71_RS15735	COG0372	Belongs to the citrate synthase family
I8N71_RS15740	COG2707	UPF0756 membrane protein
I8N71_RS15745	COG0628	permease
I8N71_RS15750	COG3030	protein affecting phage T7 exclusion by the F plasmid
I8N71_RS15755	COG0469	pyruvate kinase activity
I8N71_RS15760	COG0205	6-phosphofructokinase activity
I8N71_RS15765	COG0825	malonyl-CoA metabolic process
I8N71_RS15770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I8N71_RS15775	COG0281	malic enzyme
I8N71_RS15780	COG0587	DNA-directed DNA polymerase activity
I8N71_RS15800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I8N71_RS15810	COG4109	DRTGG domain
I8N71_RS15815	COG0730	response to heat
I8N71_RS15820	COG1473	amidohydrolase
I8N71_RS15825	COG0196	riboflavin kinase activity
I8N71_RS15830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N71_RS15835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I8N71_RS15840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N71_RS15845	COG1126	abc transporter atp-binding protein
I8N71_RS15850	COG0765	amino acid transport
I8N71_RS15855	COG0765	amino acid transport
I8N71_RS15860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N71_RS15865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N71_RS15870	COG0454	-acetyltransferase
I8N71_RS15875	COG0583	DNA-binding transcription factor activity
I8N71_RS15880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I8N71_RS15885	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS15890	COG0165	Argininosuccinate lyase
I8N71_RS15895	COG0137	argininosuccinate synthase activity
I8N71_RS15900	COG0521	Mo-molybdopterin cofactor biosynthetic process
I8N71_RS15905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I8N71_RS15915	COG0827	DNA restriction-modification system
I8N71_RS15920	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I8N71_RS15925	COG3874	Sporulation protein YtfJ
I8N71_RS15935	COG1714	RDD family
I8N71_RS15940	COG0616	signal peptide processing
I8N71_RS15945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8N71_RS15950	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I8N71_RS15955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8N71_RS15965	COG0301	tRNA thio-modification
I8N71_RS15970	COG1104	cysteine desulfurase activity
I8N71_RS15975	COG1114	Component of the transport system for branched-chain amino acids
I8N71_RS15980	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I8N71_RS15985	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I8N71_RS15990	COG1309	transcriptional regulator
I8N71_RS15995	COG1956	GAF domain-containing protein
I8N71_RS16000	COG2203	Gaf domain
I8N71_RS16000	COG2199	diguanylate cyclase activity
I8N71_RS16005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I8N71_RS16010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I8N71_RS16015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8N71_RS16020	COG0454	-acetyltransferase
I8N71_RS16025	COG0517	IMP dehydrogenase activity
I8N71_RS16030	COG0123	including yeast histone deacetylase and acetoin utilization protein
I8N71_RS16035	COG1360	Flagellar Motor Protein
I8N71_RS16040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I8N71_RS16045	COG1609	Transcriptional regulator
I8N71_RS16050	COG1605	Chorismate mutase
I8N71_RS16050	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I8N71_RS16055	COG3118	belongs to the thioredoxin family
I8N71_RS16060	COG4980	gas vesicle protein
I8N71_RS16065	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I8N71_RS16070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I8N71_RS16075	COG1674	ftsk spoiiie
I8N71_RS16080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N71_RS16085	COG4848	Belongs to the UPF0354 family
I8N71_RS16090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS16105	COG1363	Peptidase, m42
I8N71_RS16110	COG5584	Small secreted protein
I8N71_RS16115	COG0281	malic enzyme
I8N71_RS16120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N71_RS16125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I8N71_RS16135	COG0510	thiamine kinase activity
I8N71_RS16140	COG1523	belongs to the glycosyl hydrolase 13 family
I8N71_RS16145	COG1597	lipid kinase activity
I8N71_RS16155	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I8N71_RS16160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N71_RS16165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N71_RS16170	COG2252	PERMEase
I8N71_RS16175	COG4473	ABC transporter
I8N71_RS16180	COG1131	(ABC) transporter
I8N71_RS16185	COG1349	DNA-binding transcription factor activity
I8N71_RS16190	COG1187	pseudouridine synthase activity
I8N71_RS16195	COG2244	polysaccharide biosynthetic process
I8N71_RS16200	COG2081	HI0933 family
I8N71_RS16205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8N71_RS16215	COG5578	integral membrane protein
I8N71_RS16220	COG0673	inositol 2-dehydrogenase activity
I8N71_RS16225	COG1653	transport
I8N71_RS16230	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I8N71_RS16235	COG4209	transmembrane transport
I8N71_RS16240	COG2207	Transcriptional regulator
I8N71_RS16245	COG1653	transport
I8N71_RS16250	COG0395	ABC-type sugar transport system, permease component
I8N71_RS16255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N71_RS16260	COG2124	cytochrome p450
I8N71_RS16265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I8N71_RS16270	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I8N71_RS16275	COG0156	8-amino-7-oxononanoate synthase activity
I8N71_RS16280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N71_RS16285	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
I8N71_RS16290	COG1073	alpha beta
I8N71_RS16295	COG1609	Transcriptional regulator
I8N71_RS16300	COG1653	transport
I8N71_RS16305	COG1175	transmembrane transport
I8N71_RS16310	COG0395	ABC-type sugar transport system, permease component
I8N71_RS16315	COG1486	melibiose metabolic process
I8N71_RS16320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N71_RS16325	COG0495	leucyl-tRNA aminoacylation
I8N71_RS16335	COG2202	Pas domain
I8N71_RS16335	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N71_RS16340	COG2814	Major facilitator Superfamily
I8N71_RS16345	COG2433	Pfam Transposase IS66
I8N71_RS16350	COG0577	efflux transmembrane transporter activity
I8N71_RS16355	COG1136	(ABC) transporter
I8N71_RS16360	COG2205	protein histidine kinase activity
I8N71_RS16365	COG0745	RESPONSE REGULATOR receiver
I8N71_RS16370	COG0577	efflux transmembrane transporter activity
I8N71_RS16375	COG1136	(ABC) transporter
I8N71_RS16390	COG1131	(ABC) transporter
I8N71_RS16395	COG1725	Transcriptional regulator
I8N71_RS16410	COG1242	4 iron, 4 sulfur cluster binding
I8N71_RS16415	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I8N71_RS16425	COG2267	carboxylic ester hydrolase activity
I8N71_RS16430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I8N71_RS16435	COG1113	amino acid transport
I8N71_RS16440	COG0367	asparagine synthase
I8N71_RS16445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I8N71_RS16450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I8N71_RS16460	COG1506	peptidase
I8N71_RS16465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8N71_RS16470	COG1116	anion transmembrane transporter activity
I8N71_RS16475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8N71_RS16480	COG0494	nUDIX hydrolase
I8N71_RS16485	COG4824	toxin secretion phage lysis holin
I8N71_RS16490	COG0783	Belongs to the Dps family
I8N71_RS16505	COG1854	S-ribosylhomocysteine lyase activity
I8N71_RS16510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I8N71_RS16515	COG0288	reversible hydration of carbon dioxide
I8N71_RS16520	COG0254	rRNA binding
I8N71_RS16525	COG1271	oxidase subunit
I8N71_RS16530	COG1294	oxidase, subunit
I8N71_RS16540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8N71_RS16545	COG1321	iron dependent repressor
I8N71_RS16545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8N71_RS16550	COG1121	(ABC) transporter
I8N71_RS16555	COG0803	Belongs to the bacterial solute-binding protein 9 family
I8N71_RS16560	COG4948	Mandelate Racemase Muconate Lactonizing
I8N71_RS16565	COG0318	PFAM AMP-dependent synthetase and ligase
I8N71_RS16570	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I8N71_RS16575	COG0596	Alpha beta hydrolase
I8N71_RS16580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I8N71_RS16585	COG1169	isochorismate synthase
I8N71_RS16590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N71_RS16595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N71_RS16600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8N71_RS16605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N71_RS16610	COG0438	transferase activity, transferring glycosyl groups
I8N71_RS16620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N71_RS16625	COG0438	transferase activity, transferring glycosyl groups
I8N71_RS16630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N71_RS16635	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I8N71_RS16640	COG0058	SHG alpha-glucan phosphorylase activity
I8N71_RS16645	COG0297	glycogen (starch) synthase activity
I8N71_RS16650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I8N71_RS16655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I8N71_RS16660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I8N71_RS16785	COG3859	Proton-coupled thiamine transporter YuaJ
I8N71_RS16790	COG1247	-acetyltransferase
I8N71_RS16795	COG2268	Band 7 protein
I8N71_RS16800	COG1585	Membrane protein implicated in regulation of membrane protease activity
I8N71_RS16805	COG2318	DinB family
I8N71_RS16815	COG1454	alcohol dehydrogenase
I8N71_RS16820	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS16825	COG1510	regulation of RNA biosynthetic process
I8N71_RS16835	COG0569	domain protein
I8N71_RS16840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I8N71_RS16845	COG4682	membrane
I8N71_RS16850	COG1705	Flagellar rod assembly protein muramidase FlgJ
I8N71_RS16855	COG0477	Major facilitator Superfamily
I8N71_RS16860	COG5553	Cysteine dioxygenase type I
I8N71_RS16870	COG1968	undecaprenyl-diphosphatase activity
I8N71_RS16875	COG0628	permease
I8N71_RS16880	COG0673	inositol 2-dehydrogenase activity
I8N71_RS16885	COG4806	L-rhamnose isomerase
I8N71_RS16890	COG3254	rhamnose metabolic process
I8N71_RS16895	COG1070	Carbohydrate kinase
I8N71_RS16900	COG1349	DNA-binding transcription factor activity
I8N71_RS16905	COG3347	Dehydrogenase
I8N71_RS16905	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS16910	COG0840	transmembrane signaling receptor activity
I8N71_RS16915	COG0840	transmembrane signaling receptor activity
I8N71_RS16920	COG0840	transmembrane signaling receptor activity
I8N71_RS16925	COG0840	transmembrane signaling receptor activity
I8N71_RS16940	COG0432	Pfam Uncharacterised protein family UPF0047
I8N71_RS16950	COG0366	Alpha amylase catalytic
I8N71_RS16955	COG1253	flavin adenine dinucleotide binding
I8N71_RS16960	COG2738	Putative neutral zinc metallopeptidase
I8N71_RS16975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I8N71_RS16990	COG0166	Belongs to the GPI family
I8N71_RS16995	COG1979	alcohol dehydrogenase
I8N71_RS17000	COG1979	alcohol dehydrogenase
I8N71_RS17005	COG2155	Conserved Protein
I8N71_RS17010	COG1098	S1 RNA binding domain
I8N71_RS17015	COG0436	Aminotransferase
I8N71_RS17020	COG1522	sequence-specific DNA binding
I8N71_RS17025	COG2267	carboxylic ester hydrolase activity
I8N71_RS17035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I8N71_RS17040	COG2205	protein histidine kinase activity
I8N71_RS17050	COG5018	Exonuclease
I8N71_RS17055	COG2814	Major facilitator Superfamily
I8N71_RS17060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N71_RS17065	COG3011	Protein conserved in bacteria
I8N71_RS17075	COG3290	protein histidine kinase activity
I8N71_RS17080	COG4565	transcriptional regulatory protein
I8N71_RS17085	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N71_RS17090	COG3845	ABC transporter
I8N71_RS17095	COG4603	Belongs to the binding-protein-dependent transport system permease family
I8N71_RS17100	COG1079	Belongs to the binding-protein-dependent transport system permease family
I8N71_RS17105	COG3493	citrate carrier protein
I8N71_RS17115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8N71_RS17115	COG2111	Na H antiporter
I8N71_RS17120	COG2111	Na H antiporter
I8N71_RS17125	COG1006	Multisubunit Na H antiporter MnhC subunit
I8N71_RS17130	COG0651	ATP synthesis coupled electron transport
I8N71_RS17135	COG1863	multisubunit Na H antiporter MnhE subunit
I8N71_RS17140	COG2212	antiporter activity
I8N71_RS17145	COG1320	monovalent cation:proton antiporter activity
I8N71_RS17150	COG2050	protein possibly involved in aromatic compounds catabolism
I8N71_RS17155	COG2197	response regulator
I8N71_RS17170	COG0142	geranyltranstransferase activity
I8N71_RS17190	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I8N71_RS17195	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I8N71_RS17200	COG1335	isochorismatase
I8N71_RS17205	COG5506	Protein of unknown function (DUF1694)
I8N71_RS17220	COG0628	permease
I8N71_RS17235	COG1418	mRNA catabolic process
I8N71_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS17250	COG1511	domain protein
I8N71_RS17255	COG0433	COG0433 Predicted ATPase
I8N71_RS17255	COG1674	ftsk spoiiie
I8N71_RS17260	COG4499	WXG100 protein secretion system (Wss), protein YukC
I8N71_RS17265	COG5417	Belongs to the EsaB family
I8N71_RS17270	COG4842	Belongs to the WXG100 family
I8N71_RS17275	COG2508	Transcriptional regulator
I8N71_RS17275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I8N71_RS17280	COG0686	Belongs to the AlaDH PNT family
I8N71_RS17285	COG5634	Uncharacterized conserved protein (DUF2278)
I8N71_RS17290	COG3251	PFAM MbtH domain protein
I8N71_RS17295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS17300	COG1535	isochorismatase
I8N71_RS17300	COG3433	isochorismatase activity
I8N71_RS17305	COG1021	2,3-dihydroxybenzoate-AMP ligase
I8N71_RS17310	COG1169	isochorismate synthase
I8N71_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS17320	COG2819	hydrolase of the alpha beta superfamily
I8N71_RS17325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8N71_RS17330	COG1268	BioY protein
I8N71_RS17335	COG2056	Na+-H+ antiporter family
I8N71_RS17340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I8N71_RS17345	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I8N71_RS17350	COG3584	3D domain protein
I8N71_RS17365	COG1252	NADH dehydrogenase
I8N71_RS17370	COG0492	ferredoxin-NADP+ reductase activity
I8N71_RS17380	COG0516	GMP reductase activity
I8N71_RS17385	COG2808	Putative FMN-binding domain
I8N71_RS17390	COG0456	acetyltransferase
I8N71_RS17395	COG0316	Belongs to the HesB IscA family
I8N71_RS17400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I8N71_RS17405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N71_RS17410	COG4844	belongs to the
I8N71_RS17415	COG1252	NADH dehydrogenase
I8N71_RS17420	COG4837	Protein of unknown function (DUF1462)
I8N71_RS17425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I8N71_RS17430	COG0823	Involved in the tonB-independent uptake of proteins
I8N71_RS17430	COG1506	peptidase
I8N71_RS17430	COG4946	Tricorn protease homolog
I8N71_RS17435	COG0083	homoserine kinase activity
I8N71_RS17440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I8N71_RS17445	COG0460	homoserine dehydrogenase
I8N71_RS17450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N71_RS17455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I8N71_RS17460	COG0647	UMP catabolic process
I8N71_RS17465	COG2445	Protein of unknown function DUF86
I8N71_RS17470	COG4470	Protein conserved in bacteria
I8N71_RS17480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I8N71_RS17485	COG0739	heme binding
I8N71_RS17495	COG3377	Domain of unknown function (DUF1805)
I8N71_RS17500	COG0737	Belongs to the 5'-nucleotidase family
I8N71_RS17505	COG0730	response to heat
I8N71_RS17510	COG1801	Protein of unknown function DUF72
I8N71_RS17520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8N71_RS17525	COG2508	Transcriptional regulator
I8N71_RS17530	COG2233	PERMEase
I8N71_RS17535	COG2233	PERMEase
I8N71_RS17540	COG3195	allantoin biosynthetic process
I8N71_RS17540	COG3648	Uricase
I8N71_RS17545	COG2351	hydroxyisourate hydrolase activity
I8N71_RS17555	COG2080	2 iron, 2 sulfur cluster binding
I8N71_RS17560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I8N71_RS17565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I8N71_RS17570	COG2068	MobA-Related Protein
I8N71_RS17575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I8N71_RS17580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I8N71_RS17585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N71_RS17595	COG2356	endonuclease I
I8N71_RS17600	COG3842	ATPase activity
I8N71_RS17605	COG2188	Transcriptional regulator
I8N71_RS17610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N71_RS17615	COG0395	ABC-type sugar transport system, permease component
I8N71_RS17620	COG1175	transmembrane transport
I8N71_RS17625	COG1653	transport
I8N71_RS17630	COG2222	sugar isomerase
I8N71_RS17635	COG0322	excinuclease ABC activity
I8N71_RS17640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N71_RS17655	COG0346	lactoylglutathione lyase activity
I8N71_RS17660	COG0640	Transcriptional regulator
I8N71_RS17665	COG0719	Fe-S assembly protein
I8N71_RS17670	COG0822	iron-sulfur transferase activity
I8N71_RS17675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8N71_RS17680	COG0719	Fe-S assembly protein
I8N71_RS17685	COG0396	ATPase activity
I8N71_RS17695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8N71_RS17700	COG1464	Belongs to the NlpA lipoprotein family
I8N71_RS17705	COG2011	ABC-type metal ion transport system permease component
I8N71_RS17710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I8N71_RS17720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N71_RS17725	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I8N71_RS17735	COG0509	glycine decarboxylation via glycine cleavage system
I8N71_RS17740	COG1393	Belongs to the ArsC family
I8N71_RS17745	COG1960	acyl-CoA dehydrogenase activity
I8N71_RS17750	COG0183	Belongs to the thiolase family
I8N71_RS17755	COG1024	Enoyl-CoA hydratase
I8N71_RS17755	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8N71_RS17765	COG0506	proline dehydrogenase activity
I8N71_RS17775	COG5577	PFAM Coat F domain
I8N71_RS17780	COG1846	Transcriptional regulator
I8N71_RS17785	COG0477	Major facilitator Superfamily
I8N71_RS17790	COG1942	4-Oxalocrotonate Tautomerase
I8N71_RS17800	COG0583	DNA-binding transcription factor activity
I8N71_RS17810	COG1120	ATPase activity
I8N71_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS17830	COG0783	Belongs to the Dps family
I8N71_RS17835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N71_RS17840	COG0745	RESPONSE REGULATOR receiver
I8N71_RS17845	COG2205	protein histidine kinase activity
I8N71_RS17845	COG2770	Histidine kinase
I8N71_RS17855	COG1309	transcriptional regulator
I8N71_RS17860	COG0114	fumarate hydratase activity
I8N71_RS17870	COG0697	spore germination
I8N71_RS17875	COG0814	amino acid
I8N71_RS17885	COG2197	response regulator
I8N71_RS17890	COG4585	Histidine kinase
I8N71_RS17895	COG4758	membrane
I8N71_RS17900	COG3595	metallopeptidase activity
I8N71_RS17905	COG1842	Phage shock protein A
I8N71_RS17910	COG4758	membrane
I8N71_RS17915	COG2814	Major facilitator Superfamily
I8N71_RS17920	COG2096	Adenosyltransferase
I8N71_RS17925	COG1120	ATPase activity
I8N71_RS17930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS17935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N71_RS17940	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS17945	COG3386	PFAM SMP-30 Gluconolaconase
I8N71_RS17950	COG2205	protein histidine kinase activity
I8N71_RS17955	COG0745	RESPONSE REGULATOR receiver
I8N71_RS17965	COG1191	sigma factor activity
I8N71_RS17975	COG2140	Oxalate decarboxylase
I8N71_RS17985	COG0577	efflux transmembrane transporter activity
I8N71_RS17990	COG1136	(ABC) transporter
I8N71_RS17995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8N71_RS18000	COG1120	ATPase activity
I8N71_RS18005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS18010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N71_RS18015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N71_RS18020	COG0531	amino acid
I8N71_RS18030	COG1988	membrane-bound metal-dependent
I8N71_RS18035	COG1368	sulfuric ester hydrolase activity
I8N71_RS18040	COG1910	domain protein
I8N71_RS18045	COG0725	ABC transporter, periplasmic molybdate-binding protein
I8N71_RS18050	COG4149	molybdate abc transporter
I8N71_RS18055	COG0656	L-ascorbic acid biosynthetic process
I8N71_RS18065	COG0025	NhaP-type Na H and K H
I8N71_RS18070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8N71_RS18075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N71_RS18080	COG3973	AAA domain
I8N71_RS18085	COG2860	membrane
I8N71_RS18090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I8N71_RS18095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I8N71_RS18100	COG2217	Heavy metal translocating P-type atpase
I8N71_RS18105	COG2217	Heavy metal translocating P-type atpase
I8N71_RS18110	COG2608	mercury ion transmembrane transporter activity
I8N71_RS18115	COG1937	Protein conserved in bacteria
I8N71_RS18120	COG0673	inositol 2-dehydrogenase activity
I8N71_RS18125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8N71_RS18130	COG1289	transmembrane transporter activity
I8N71_RS18140	COG2076	Multidrug Resistance protein
I8N71_RS18145	COG1309	transcriptional regulator
I8N71_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS18160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I8N71_RS18165	COG0557	exoribonuclease II activity
I8N71_RS18170	COG1647	Serine aminopeptidase, S33
I8N71_RS18175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8N71_RS18180	COG0596	Alpha beta hydrolase
I8N71_RS18185	COG1476	TRANSCRIPTIONal
I8N71_RS18190	COG1396	sequence-specific DNA binding
I8N71_RS18195	COG1396	sequence-specific DNA binding
I8N71_RS18200	COG1733	regulation of RNA biosynthetic process
I8N71_RS18205	COG0840	transmembrane signaling receptor activity
I8N71_RS18210	COG1174	glycine betaine transport
I8N71_RS18215	COG1732	Glycine betaine
I8N71_RS18220	COG1174	glycine betaine transport
I8N71_RS18225	COG1125	glycine betaine transport
I8N71_RS18225	COG0517	IMP dehydrogenase activity
I8N71_RS18230	COG1510	regulation of RNA biosynthetic process
I8N71_RS18250	COG5658	integral membrane protein
I8N71_RS18255	COG0640	Transcriptional regulator
I8N71_RS18260	COG1174	glycine betaine transport
I8N71_RS18265	COG1732	Glycine betaine
I8N71_RS18270	COG1174	glycine betaine transport
I8N71_RS18275	COG0517	IMP dehydrogenase activity
I8N71_RS18275	COG1125	glycine betaine transport
I8N71_RS18280	COG1510	regulation of RNA biosynthetic process
I8N71_RS18285	COG2095	MarC family integral membrane protein
I8N71_RS18295	COG3064	Membrane
I8N71_RS18300	COG4640	response to antibiotic
I8N71_RS18305	COG0456	acetyltransferase
I8N71_RS18310	COG0148	phosphopyruvate hydratase activity
I8N71_RS18315	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I8N71_RS18320	COG0149	triose-phosphate isomerase activity
I8N71_RS18325	COG0126	phosphoglycerate kinase activity
I8N71_RS18330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8N71_RS18335	COG2390	Transcriptional regulator
I8N71_RS18340	COG2814	Major facilitator Superfamily
I8N71_RS18345	COG1609	Transcriptional regulator
I8N71_RS18350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N71_RS18355	COG0583	DNA-binding transcription factor activity
I8N71_RS18360	COG0697	spore germination
I8N71_RS18365	COG1113	amino acid transport
I8N71_RS18370	COG3858	chitin binding
I8N71_RS18375	COG1556	Lactate utilization protein
I8N71_RS18380	COG1139	Iron-sulfur cluster binding protein
I8N71_RS18385	COG0247	lactate metabolic process
I8N71_RS18390	COG2197	response regulator
I8N71_RS18395	COG4585	Histidine kinase
I8N71_RS18400	COG0842	Transport permease protein
I8N71_RS18405	COG1131	(ABC) transporter
I8N71_RS18410	COG0596	Alpha beta hydrolase
I8N71_RS18415	COG2208	phosphoserine phosphatase activity
I8N71_RS18420	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I8N71_RS18425	COG1874	Beta-galactosidase
I8N71_RS18430	COG3833	ABC-type maltose transport systems, permease component
I8N71_RS18435	COG1175	transmembrane transport
I8N71_RS18440	COG2182	Extracellular solute-binding protein
I8N71_RS18445	COG1609	Transcriptional regulator
I8N71_RS18450	COG2186	Transcriptional regulator
I8N71_RS18455	COG1620	l-lactate permease
I8N71_RS18460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I8N71_RS18470	COG5039	Polysaccharide pyruvyl transferase
I8N71_RS18475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N71_RS18480	COG0110	maltose O-acetyltransferase activity
I8N71_RS18485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I8N71_RS18490	COG2244	polysaccharide biosynthetic process
I8N71_RS18495	COG1216	Glycosyl transferase, family 2
I8N71_RS18500	COG5039	Polysaccharide pyruvyl transferase
I8N71_RS18505	COG1216	Glycosyl transferase, family 2
I8N71_RS18515	COG0438	transferase activity, transferring glycosyl groups
I8N71_RS18520	COG1215	transferase activity, transferring glycosyl groups
I8N71_RS18525	COG0438	transferase activity, transferring glycosyl groups
I8N71_RS18530	COG1086	Polysaccharide biosynthesis protein
I8N71_RS18535	COG0489	protein tyrosine kinase activity
I8N71_RS18540	COG3944	biosynthesis protein
I8N71_RS18545	COG1396	sequence-specific DNA binding
I8N71_RS18550	COG2272	Belongs to the type-B carboxylesterase lipase family
I8N71_RS18560	COG3479	Phenolic acid decarboxylase
I8N71_RS18570	COG1794	racemase activity, acting on amino acids and derivatives
I8N71_RS18575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N71_RS18580	COG1621	beta-fructofuranosidase activity
I8N71_RS18585	COG1621	beta-fructofuranosidase activity
I8N71_RS18590	COG0531	amino acid
I8N71_RS18595	COG1309	transcriptional regulator
I8N71_RS18600	COG2076	Multidrug Resistance protein
I8N71_RS18605	COG2076	Multidrug Resistance protein
I8N71_RS18615	COG0277	FAD linked oxidase domain protein
I8N71_RS18620	COG3621	Patatin-like phospholipase
I8N71_RS18630	COG0740	serine-type endopeptidase activity
I8N71_RS18635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8N71_RS18640	COG0366	Alpha amylase catalytic
I8N71_RS18645	COG1554	hydrolase, family 65, central catalytic
I8N71_RS18650	COG5521	maltodextrose utilization protein MalA
I8N71_RS18655	COG3833	ABC-type maltose transport systems, permease component
I8N71_RS18660	COG1175	transmembrane transport
I8N71_RS18665	COG2182	Extracellular solute-binding protein
I8N71_RS18670	COG0366	Alpha amylase catalytic
I8N71_RS18675	COG1609	Transcriptional regulator
I8N71_RS18680	COG1611	Belongs to the LOG family
I8N71_RS18685	COG1694	Mazg nucleotide pyrophosphohydrolase
I8N71_RS18690	COG0659	secondary active sulfate transmembrane transporter activity
I8N71_RS18695	COG0288	reversible hydration of carbon dioxide
I8N71_RS18700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I8N71_RS18705	COG0577	efflux transmembrane transporter activity
I8N71_RS18710	COG1136	(ABC) transporter
I8N71_RS18715	COG5002	protein histidine kinase activity
I8N71_RS18720	COG0745	RESPONSE REGULATOR receiver
I8N71_RS18730	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I8N71_RS18735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N71_RS18740	COG1481	regulation of sporulation
I8N71_RS18745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I8N71_RS18750	COG1660	Displays ATPase and GTPase activities
I8N71_RS18755	COG1051	belongs to the nudix hydrolase family
I8N71_RS18760	COG0492	ferredoxin-NADP+ reductase activity
I8N71_RS18765	COG0791	NLP P60 protein
I8N71_RS18765	COG3883	PFAM NLP P60 protein
I8N71_RS18770	COG0457	Tetratricopeptide repeat
I8N71_RS18775	COG1132	(ABC) transporter
I8N71_RS18795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I8N71_RS18795	COG0140	phosphoribosyl-ATP diphosphatase activity
I8N71_RS18800	COG0107	imidazoleglycerol-phosphate synthase activity
I8N71_RS18805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I8N71_RS18810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I8N71_RS18815	COG0131	Imidazoleglycerol-phosphate dehydratase
I8N71_RS18820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I8N71_RS18825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I8N71_RS18830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I8N71_RS18835	COG4990	cell redox homeostasis
I8N71_RS18840	COG5297	Belongs to the glycosyl hydrolase family 6
I8N71_RS18845	COG0110	maltose O-acetyltransferase activity
I8N71_RS18850	COG0546	phosphoglycolate phosphatase activity
I8N71_RS18855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I8N71_RS18860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I8N71_RS18865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I8N71_RS18870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I8N71_RS18875	COG0363	glucosamine-6-phosphate deaminase activity
I8N71_RS18880	COG2188	Transcriptional regulator
I8N71_RS18885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8N71_RS18890	COG1846	Transcriptional regulator
I8N71_RS18895	COG2124	cytochrome p450
I8N71_RS18905	COG1846	Transcriptional regulator
I8N71_RS18910	COG2814	Major facilitator Superfamily
I8N71_RS18915	COG1950	PFAM Membrane protein of
I8N71_RS18920	COG1983	PspC domain protein
I8N71_RS18925	COG3595	metallopeptidase activity
I8N71_RS18945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I8N71_RS18950	COG0556	nucleotide-excision repair
I8N71_RS18955	COG4897	Protein conserved in bacteria
I8N71_RS18960	COG0574	Belongs to the PEP-utilizing enzyme family
I8N71_RS18960	COG3848	Pyruvate phosphate dikinase
I8N71_RS18965	COG1309	transcriptional regulator
I8N71_RS18970	COG2814	Major facilitator Superfamily
I8N71_RS18975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N71_RS18985	COG3409	Peptidoglycan-binding domain 1 protein
I8N71_RS18985	COG0793	Belongs to the peptidase S41A family
I8N71_RS18990	COG2177	Part of the ABC transporter FtsEX involved in
I8N71_RS18995	COG2884	Cell division ATP-binding protein ftsE
I8N71_RS19000	COG2010	Cytochrome c
I8N71_RS19005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N71_RS19015	COG0653	protein targeting
I8N71_RS19020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I8N71_RS19035	COG1516	flagellar protein fliS
I8N71_RS19040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I8N71_RS19045	COG1334	flagellar protein FlaG
I8N71_RS19050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8N71_RS19055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I8N71_RS19060	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I8N71_RS19070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8N71_RS19075	COG1256	bacterial-type flagellum assembly
I8N71_RS19075	COG4786	Flagellar basal body rod
I8N71_RS19080	COG3418	PFAM FlgN family protein
I8N71_RS19085	COG2747	anti-sigma28 factor FlgM
I8N71_RS19095	COG1040	competence protein
I8N71_RS19105	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I8N71_RS19110	COG1307	EDD domain protein, DegV family
I8N71_RS19115	COG2197	response regulator
I8N71_RS19120	COG4585	Histidine kinase
I8N71_RS19125	COG1739	Uncharacterized protein family UPF0029
I8N71_RS19130	COG1316	TRANSCRIPTIONal
I8N71_RS19135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I8N71_RS19140	COG0438	transferase activity, transferring glycosyl groups
I8N71_RS19145	COG1215	transferase activity, transferring glycosyl groups
I8N71_RS19150	COG3206	protein involved in exopolysaccharide biosynthesis
I8N71_RS19155	COG3307	-O-antigen
I8N71_RS19160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8N71_RS19165	COG0438	transferase activity, transferring glycosyl groups
I8N71_RS19165	COG0297	glycogen (starch) synthase activity
I8N71_RS19170	COG2244	polysaccharide biosynthetic process
I8N71_RS19180	COG2247	cell wall binding repeat
I8N71_RS19180	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N71_RS19185	COG2385	sporulation resulting in formation of a cellular spore
I8N71_RS19185	COG2247	cell wall binding repeat
I8N71_RS19195	COG1316	TRANSCRIPTIONal
I8N71_RS19200	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I8N71_RS19205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N71_RS19215	COG1215	transferase activity, transferring glycosyl groups
I8N71_RS19215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N71_RS19220	COG0463	Glycosyl transferase, family 2
I8N71_RS19230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N71_RS19240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N71_RS19245	COG1134	teichoic acid transport
I8N71_RS19250	COG1682	transport, permease protein
I8N71_RS19255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N71_RS19260	COG0438	transferase activity, transferring glycosyl groups
I8N71_RS19265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I8N71_RS19270	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I8N71_RS19275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N71_RS19285	COG4193	domain, Protein
I8N71_RS19290	COG1482	cell wall glycoprotein biosynthetic process
I8N71_RS19295	COG0697	spore germination
I8N71_RS19300	COG0814	amino acid
I8N71_RS19310	COG2814	Major facilitator Superfamily
I8N71_RS19315	COG1316	TRANSCRIPTIONal
I8N71_RS19320	COG0561	phosphatase activity
I8N71_RS19325	COG0791	NLP P60 protein
I8N71_RS19335	COG2843	Capsule synthesis protein
I8N71_RS19345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I8N71_RS19350	COG1609	Transcriptional regulator
I8N71_RS19355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N71_RS19360	COG1869	D-ribose catabolic process
I8N71_RS19365	COG1129	ABC transporter
I8N71_RS19370	COG1172	Belongs to the binding-protein-dependent transport system permease family
I8N71_RS19375	COG1879	ABC-type sugar transport system periplasmic component
I8N71_RS19380	COG3103	Sh3 type 3 domain protein
I8N71_RS19390	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N71_RS19395	COG3527	Alpha-acetolactate decarboxylase
I8N71_RS19400	COG0028	Belongs to the TPP enzyme family
I8N71_RS19405	COG0583	DNA-binding transcription factor activity
I8N71_RS19410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I8N71_RS19425	COG5337	Spore coat protein CotH
I8N71_RS19435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8N71_RS19445	COG0405	Gamma-glutamyltransferase
I8N71_RS19450	COG1522	sequence-specific DNA binding
I8N71_RS19455	COG2059	Chromate
I8N71_RS19460	COG2059	Chromate
I8N71_RS19470	COG0655	NAD(P)H dehydrogenase (quinone) activity
I8N71_RS19475	COG0583	DNA-binding transcription factor activity
I8N71_RS19480	COG1515	deoxyribonuclease V activity
I8N71_RS19485	COG2849	repeat protein
I8N71_RS19490	COG5444	nuclease activity
I8N71_RS19510	COG3878	Protein conserved in bacteria
I8N71_RS19515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8N71_RS19520	COG4464	protein tyrosine phosphatase activity
I8N71_RS19525	COG0489	protein tyrosine kinase activity
I8N71_RS19530	COG3944	biosynthesis protein
I8N71_RS19540	COG4715	Zinc finger, swim domain protein
I8N71_RS19545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8N71_RS19550	COG0561	phosphatase activity
I8N71_RS19555	COG1349	DNA-binding transcription factor activity
I8N71_RS19560	COG0629	single-stranded DNA binding
I8N71_RS19585	COG0745	RESPONSE REGULATOR receiver
I8N71_RS19585	COG2972	Histidine kinase
I8N71_RS19590	COG1970	mechanosensitive ion channel activity
I8N71_RS19595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I8N71_RS19600	COG0457	Tetratricopeptide repeat
I8N71_RS19605	COG4786	Flagellar basal body rod
I8N71_RS19610	COG4786	Flagellar basal body rod
I8N71_RS19615	COG1077	Cell shape determining protein MreB Mrl
I8N71_RS19620	COG1609	Transcriptional regulator
I8N71_RS19630	COG1846	Transcriptional regulator
I8N71_RS19635	COG2814	Major facilitator Superfamily
I8N71_RS19640	COG3420	alginic acid biosynthetic process
I8N71_RS19645	COG1953	Uracil, thiamine, allantoin
I8N71_RS19650	COG0477	Major facilitator Superfamily
I8N71_RS19655	COG1335	isochorismatase
I8N71_RS19665	COG0004	ammonium transporteR
I8N71_RS19670	COG0347	Belongs to the P(II) protein family
I8N71_RS19675	COG0671	phosphoesterase, PA-phosphatase related
I8N71_RS19685	COG0739	heme binding
I8N71_RS19690	COG1247	-acetyltransferase
I8N71_RS19710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N71_RS19715	COG0789	Transcriptional regulator
I8N71_RS19725	COG2910	NAD(P)H-binding
I8N71_RS19730	COG1959	2 iron, 2 sulfur cluster binding
I8N71_RS19735	COG0804	urea catabolic process
I8N71_RS19740	COG0832	Belongs to the urease beta subunit family
I8N71_RS19745	COG0831	urea catabolic process
I8N71_RS19760	COG3237	CsbD-like
I8N71_RS19765	COG1994	Peptidase M50
I8N71_RS19770	COG0457	Tetratricopeptide repeat
I8N71_RS19775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I8N71_RS19780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I8N71_RS19790	COG2304	oxidoreductase activity
I8N71_RS19800	COG2304	oxidoreductase activity
I8N71_RS19805	COG2385	sporulation resulting in formation of a cellular spore
I8N71_RS19810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8N71_RS19820	COG4836	Membrane
I8N71_RS19830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I8N71_RS19835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I8N71_RS19840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I8N71_RS19845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I8N71_RS19850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I8N71_RS19855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I8N71_RS19865	COG0356	it plays a direct role in the translocation of protons across the membrane
I8N71_RS19875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I8N71_RS19880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I8N71_RS19885	COG4475	Protein of unknown function (DUF436)
I8N71_RS19890	COG0698	ribose 5-phosphate isomerase
I8N71_RS19895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8N71_RS19900	COG1971	Probably functions as a manganese efflux pump
I8N71_RS19905	COG0009	L-threonylcarbamoyladenylate synthase
I8N71_RS19910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I8N71_RS19930	COG2890	protein-(glutamine-N5) methyltransferase activity
I8N71_RS19935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I8N71_RS19940	COG0346	lactoylglutathione lyase activity
I8N71_RS19945	COG0789	Transcriptional regulator
I8N71_RS19950	COG0679	Auxin Efflux Carrier
I8N71_RS19955	COG0281	malic enzyme
I8N71_RS19960	COG1435	thymidine kinase activity
I8N71_RS19970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I8N71_RS19980	COG1494	fructose-1,6-bisphosphatase
I8N71_RS19985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8N71_RS19990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I8N71_RS19995	COG0191	fructose-bisphosphate aldolase activity
I8N71_RS20000	COG2204	response regulator
I8N71_RS20005	COG4821	SIS domain
I8N71_RS20010	COG0504	CTP synthase activity
I8N71_RS20015	COG3343	RNA polymerase activity
I8N71_RS20020	COG1960	acyl-CoA dehydrogenase activity
I8N71_RS20025	COG0247	lactate metabolic process
I8N71_RS20025	COG2181	nitrate reductase activity
I8N71_RS20030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N71_RS20035	COG4294	response to UV
I8N71_RS20045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N71_RS20050	COG1132	(ABC) transporter
I8N71_RS20055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N71_RS20060	COG2181	nitrate reductase activity
I8N71_RS20065	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I8N71_RS20070	COG1140	nitrate reductase beta subunit
I8N71_RS20075	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I8N71_RS20080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N71_RS20090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N71_RS20095	COG2223	nitrite transmembrane transporter activity
I8N71_RS20100	COG0018	arginyl-trna synthetase
I8N71_RS20105	COG4506	Protein conserved in bacteria
I8N71_RS20120	COG0535	radical SAM domain protein
I8N71_RS20130	COG1131	(ABC) transporter
I8N71_RS20135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I8N71_RS20140	COG0612	Peptidase, M16
I8N71_RS20145	COG0612	Peptidase, M16
I8N71_RS20155	COG3391	amine dehydrogenase activity
I8N71_RS20160	COG3391	amine dehydrogenase activity
I8N71_RS20165	COG0457	Tetratricopeptide repeat
I8N71_RS20175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I8N71_RS20180	COG0010	Belongs to the arginase family
I8N71_RS20185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I8N71_RS20190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N71_RS20200	COG1994	Peptidase M50
I8N71_RS20205	COG1942	4-Oxalocrotonate Tautomerase
I8N71_RS20210	COG1846	Transcriptional regulator
I8N71_RS20215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I8N71_RS20220	COG0477	Major facilitator Superfamily
I8N71_RS20225	COG1959	2 iron, 2 sulfur cluster binding
I8N71_RS20230	COG3465	dGTPase activity
I8N71_RS20235	COG1078	dGTPase activity
I8N71_RS20240	COG4844	belongs to the
I8N71_RS20250	COG0697	spore germination
I8N71_RS20255	COG0095	Lipoate-protein ligase
I8N71_RS20260	COG0583	DNA-binding transcription factor activity
I8N71_RS20265	COG0280	phosphate acetyltransferase
I8N71_RS20270	COG3253	May function as heme-dependent peroxidase
I8N71_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS20280	COG0436	Aminotransferase
I8N71_RS20285	COG2814	Major facilitator Superfamily
I8N71_RS20290	COG0151	Belongs to the GarS family
I8N71_RS20295	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS20300	COG1917	Cupin 2, conserved barrel domain protein
I8N71_RS20305	COG0077	Prephenate dehydratase
I8N71_RS20310	COG2814	Major facilitator Superfamily
I8N71_RS20315	COG0833	amino acid
I8N71_RS20320	COG4187	Peptidase family M20/M25/M40
I8N71_RS20325	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS20330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N71_RS20340	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I8N71_RS20345	COG1091	dTDP-4-dehydrorhamnose reductase activity
I8N71_RS20350	COG1088	dTDP-glucose 4,6-dehydratase activity
I8N71_RS20355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I8N71_RS20360	COG3980	spore coat polysaccharide biosynthesis protein
I8N71_RS20365	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I8N71_RS20370	COG2089	acid synthase
I8N71_RS20375	COG0456	acetyltransferase
I8N71_RS20380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N71_RS20385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N71_RS20390	COG0463	Glycosyl transferase, family 2
I8N71_RS20400	COG2363	Small membrane protein
I8N71_RS20405	COG2233	PERMEase
I8N71_RS20415	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS20420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I8N71_RS20425	COG1216	Glycosyl transferase, family 2
I8N71_RS20440	COG1695	Transcriptional regulator
I8N71_RS20445	COG0351	phosphomethylpyrimidine kinase
I8N71_RS20455	COG1621	beta-fructofuranosidase activity
I8N71_RS20460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS20460	COG1263	PTS System
I8N71_RS20465	COG2116	formate transmembrane transporter activity
I8N71_RS20470	COG3711	transcriptional antiterminator
I8N71_RS20480	COG1404	Belongs to the peptidase S8 family
I8N71_RS20485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N71_RS20490	COG0778	Nitroreductase
I8N71_RS20495	COG0772	Belongs to the SEDS family
I8N71_RS20505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I8N71_RS20510	COG1845	cytochrome c oxidase, subunit III
I8N71_RS20515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8N71_RS20520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8N71_RS20525	COG2261	transglycosylase associated protein
I8N71_RS20530	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I8N71_RS20535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I8N71_RS20540	COG2246	polysaccharide biosynthetic process
I8N71_RS20545	COG1309	transcriptional regulator
I8N71_RS20555	COG3162	membrane
I8N71_RS20560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N71_RS20565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8N71_RS20570	COG2837	iron assimilation
I8N71_RS20575	COG2822	iron ion transport
I8N71_RS20580	COG0672	)-iron permease
I8N71_RS20585	COG0352	thiamine-phosphate diphosphorylase activity
I8N71_RS20590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I8N71_RS20595	COG0583	DNA-binding transcription factor activity
I8N71_RS20600	COG1380	Effector of murein hydrolase LrgA
I8N71_RS20605	COG1346	cytolysis
I8N71_RS20610	COG2814	Major facilitator Superfamily
I8N71_RS20615	COG4895	conserved protein (DUF2196)
I8N71_RS20620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I8N71_RS20625	COG0346	lactoylglutathione lyase activity
I8N71_RS20635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N71_RS20640	COG1404	Belongs to the peptidase S8 family
I8N71_RS20645	COG1263	PTS System
I8N71_RS20645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS20650	COG3711	transcriptional antiterminator
I8N71_RS20655	COG1442	glycosyl transferase family 8
I8N71_RS20660	COG5522	Integral membrane protein (intg_mem_TP0381)
I8N71_RS20665	COG1846	Transcriptional regulator
I8N71_RS20670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I8N71_RS20675	COG2234	aminopeptidase activity
I8N71_RS20680	COG2357	RelA SpoT domain protein
I8N71_RS20685	COG1575	Belongs to the MenA family. Type 1 subfamily
I8N71_RS20700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N71_RS20705	COG1696	Membrane protein involved in D-alanine export
I8N71_RS20710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N71_RS20715	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I8N71_RS20720	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I8N71_RS20725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N71_RS20730	COG1486	melibiose metabolic process
I8N71_RS20735	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N71_RS20740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N71_RS20745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N71_RS20750	COG3711	transcriptional antiterminator
I8N71_RS20750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N71_RS20760	COG2094	Belongs to the DNA glycosylase MPG family
I8N71_RS20765	COG0753	catalase activity
I8N71_RS20770	COG2814	Major facilitator Superfamily
I8N71_RS20775	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N71_RS20780	COG1131	(ABC) transporter
I8N71_RS20800	COG1595	DNA-templated transcription, initiation
I8N71_RS20805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8N71_RS20810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I8N71_RS20815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I8N71_RS20820	COG4988	ABC transporter
I8N71_RS20825	COG1294	oxidase, subunit
I8N71_RS20830	COG1271	oxidase subunit
I8N71_RS20835	COG3493	citrate carrier protein
I8N71_RS20840	COG0501	Belongs to the peptidase M48B family
I8N71_RS20850	COG0726	polysaccharide deacetylase
I8N71_RS20855	COG3842	ATPase activity
I8N71_RS20860	COG2508	Transcriptional regulator
I8N71_RS20865	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS20870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N71_RS20880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I8N71_RS20885	COG1881	PFAM PEBP family protein
I8N71_RS20890	COG0583	DNA-binding transcription factor activity
I8N71_RS20900	COG4585	Histidine kinase
I8N71_RS20905	COG2197	response regulator
I8N71_RS20910	COG2195	Cleaves the N-terminal amino acid of tripeptides
I8N71_RS20920	COG4894	glucomannan catabolic process
I8N71_RS20925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I8N71_RS20930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I8N71_RS20935	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS20940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8N71_RS20945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8N71_RS20950	COG2610	gluconate transmembrane transporter activity
I8N71_RS20955	COG0500	methyltransferase
I8N71_RS20960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N71_RS20975	COG0693	protein deglycase activity
I8N71_RS20975	COG0753	catalase activity
I8N71_RS20980	COG2851	Citrate transporter
I8N71_RS20985	COG2273	Hydrolase Family 16
I8N71_RS20990	COG3711	transcriptional antiterminator
I8N71_RS21000	COG2270	Major facilitator Superfamily
I8N71_RS21005	COG0513	Belongs to the DEAD box helicase family
I8N71_RS21010	COG3401	FG-GAP repeat protein
I8N71_RS21010	COG2755	lipolytic protein G-D-S-L family
I8N71_RS21070	COG3209	COG3209 Rhs family protein
I8N71_RS21075	COG0697	spore germination
I8N71_RS21080	COG0589	response to stress
I8N71_RS21085	COG2723	6-phospho-beta-galactosidase activity
I8N71_RS21090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N71_RS21090	COG1263	PTS System
I8N71_RS21090	COG2190	(PTS) system
I8N71_RS21105	COG5444	nuclease activity
I8N71_RS21120	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N71_RS21135	COG2986	histidine ammonia-lyase
I8N71_RS21140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I8N71_RS21145	COG1228	amidohydrolase
I8N71_RS21150	COG0010	Belongs to the arginase family
I8N71_RS21155	COG0833	amino acid
I8N71_RS21160	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I8N71_RS21165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N71_RS21170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I8N71_RS21175	COG2390	Transcriptional regulator
I8N71_RS21185	COG3192	ethanolamine utilization protein
I8N71_RS21190	COG2079	MmgE PrpD family protein
I8N71_RS21195	COG1473	amidohydrolase
I8N71_RS21200	COG1126	abc transporter atp-binding protein
I8N71_RS21205	COG0765	amino acid transport
I8N71_RS21210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N71_RS21215	COG0456	acetyltransferase
I8N71_RS21220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N71_RS21230	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I8N71_RS21235	COG0561	phosphatase activity
I8N71_RS21265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N71_RS21270	COG5294	Protein conserved in bacteria
I8N71_RS21275	COG0577	efflux transmembrane transporter activity
I8N71_RS21280	COG1136	(ABC) transporter
I8N71_RS21285	COG2205	protein histidine kinase activity
I8N71_RS21290	COG0745	RESPONSE REGULATOR receiver
I8N71_RS21295	COG0191	fructose-bisphosphate aldolase activity
I8N71_RS21300	COG1082	Xylose isomerase domain protein TIM barrel
I8N71_RS21305	COG1082	Xylose isomerase domain protein TIM barrel
I8N71_RS21310	COG0673	inositol 2-dehydrogenase activity
I8N71_RS21315	COG2814	Major facilitator Superfamily
I8N71_RS21320	COG1082	Xylose isomerase domain protein TIM barrel
I8N71_RS21325	COG3962	Belongs to the TPP enzyme family
I8N71_RS21330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N71_RS21335	COG3718	enzyme involved in inositol metabolism
I8N71_RS21340	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS21345	COG1349	DNA-binding transcription factor activity
I8N71_RS21350	COG0667	Aldo Keto reductase
I8N71_RS21365	COG2814	Major facilitator Superfamily
I8N71_RS21370	COG0326	Molecular chaperone. Has ATPase activity
I8N71_RS21380	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS21385	COG1309	transcriptional regulator
I8N71_RS21390	COG1012	belongs to the aldehyde dehydrogenase family
I8N71_RS21395	COG0456	acetyltransferase
I8N71_RS21400	COG2850	peptidyl-arginine hydroxylation
I8N71_RS21405	COG2226	methyltransferase
I8N71_RS21420	COG0367	asparagine synthase
I8N71_RS21425	COG2814	Major facilitator Superfamily
I8N71_RS21430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I8N71_RS21440	COG1714	RDD family
I8N71_RS21445	COG2311	Membrane
I8N71_RS21450	COG1917	Cupin 2, conserved barrel domain protein
I8N71_RS21455	COG1309	transcriptional regulator
I8N71_RS21460	COG1028	Short-chain dehydrogenase reductase Sdr
I8N71_RS21465	COG1846	Transcriptional regulator
I8N71_RS21470	COG1380	Effector of murein hydrolase LrgA
I8N71_RS21475	COG1346	cytolysis
I8N71_RS21480	COG5039	Polysaccharide pyruvyl transferase
I8N71_RS21485	COG1929	Belongs to the glycerate kinase type-1 family
I8N71_RS21490	COG1802	Transcriptional regulator
I8N71_RS21495	COG1070	Carbohydrate kinase
I8N71_RS21500	COG2610	gluconate transmembrane transporter activity
I8N71_RS21505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I8N71_RS21510	COG0450	alkyl hydroperoxide reductase
I8N71_RS21515	COG3634	alkyl hydroperoxide reductase activity
I8N71_RS21520	COG2723	6-phospho-beta-galactosidase activity
I8N71_RS21530	COG2188	Transcriptional regulator
I8N71_RS21545	COG1131	(ABC) transporter
I8N71_RS21550	COG1994	Peptidase M50
I8N71_RS21555	COG0535	radical SAM domain protein
I8N71_RS21565	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I8N71_RS21570	COG5293	efflux transmembrane transporter activity
I8N71_RS21580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8N71_RS21585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I8N71_RS21600	COG1063	alcohol dehydrogenase
I8N71_RS21620	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I8N71_RS21625	COG0456	acetyltransferase
I8N71_RS21630	COG0457	Tetratricopeptide repeat
I8N71_RS21640	COG0010	Belongs to the arginase family
I8N71_RS21645	COG0833	amino acid
I8N71_RS21650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8N71_RS21655	COG3829	transcription factor binding
I8N71_RS21670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N71_RS21675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I8N71_RS21680	COG4853	Protein conserved in bacteria
I8N71_RS21685	COG4863	YycH protein
I8N71_RS21690	COG5002	protein histidine kinase activity
I8N71_RS21695	COG0745	RESPONSE REGULATOR receiver
I8N71_RS21725	COG0346	lactoylglutathione lyase activity
I8N71_RS21730	COG0305	Participates in initiation and elongation during chromosome replication
I8N71_RS21745	COG3093	addiction module antidote protein HigA
I8N71_RS21750	COG2807	transmembrane transport
I8N71_RS21755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8N71_RS21760	COG0359	binds to the 23S rRNA
I8N71_RS21765	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I8N71_RS21770	COG4241	membrane
I8N71_RS21780	COG5577	PFAM Coat F domain
I8N71_RS21785	COG1733	regulation of RNA biosynthetic process
I8N71_RS21790	COG1227	inorganic diphosphatase activity
I8N71_RS21805	COG2271	Major facilitator Superfamily
I8N71_RS21845	COG1131	(ABC) transporter
I8N71_RS21860	COG4319	ketosteroid isomerase
I8N71_RS21865	COG1357	PFAM Pentapeptide repeats (8 copies)
I8N71_RS21870	COG2814	Major facilitator Superfamily
I8N71_RS21875	COG0583	DNA-binding transcription factor activity
I8N71_RS21880	COG2153	protein acetylation
I8N71_RS21890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N71_RS21895	COG1846	Transcriptional regulator
I8N71_RS21900	COG2153	protein acetylation
I8N71_RS21905	COG2364	Membrane
I8N71_RS21910	COG0456	acetyltransferase
I8N71_RS21915	COG2315	Protein conserved in bacteria
I8N71_RS21920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N71_RS21930	COG2814	Major facilitator Superfamily
I8N71_RS21940	COG1331	Highly conserved protein containing a thioredoxin domain
I8N71_RS21945	COG0789	Transcriptional regulator
I8N71_RS21950	COG0697	spore germination
I8N71_RS21955	COG1331	Highly conserved protein containing a thioredoxin domain
I8N71_RS21960	COG1266	CAAX protease self-immunity
I8N71_RS21965	COG0477	Major facilitator Superfamily
I8N71_RS21965	COG2814	Major facilitator Superfamily
I8N71_RS21970	COG0110	maltose O-acetyltransferase activity
I8N71_RS21975	COG0346	lactoylglutathione lyase activity
I8N71_RS21980	COG1609	Transcriptional regulator
I8N71_RS21985	COG0708	Exodeoxyribonuclease III
I8N71_RS21990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I8N71_RS21995	COG0629	single-stranded DNA binding
I8N71_RS22000	COG0360	Binds together with S18 to 16S ribosomal RNA
I8N71_RS22005	COG0012	GTP binding
I8N71_RS22010	COG0243	molybdopterin cofactor binding
I8N71_RS22015	COG4481	Protein conserved in bacteria
I8N71_RS22020	COG3949	Membrane
I8N71_RS22030	COG1475	DNA binding
I8N71_RS22035	COG1192	Involved in chromosome partitioning
I8N71_RS22045	COG1475	DNA binding
I8N71_RS22050	COG0357	Ribosomal RNA small subunit methyltransferase G
I8N71_RS22055	COG0445	tRNA wobble uridine modification
I8N71_RS22060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I8N71_RS22065	COG1847	R3H domain protein
I8N71_RS22070	COG0706	membrane insertase activity
I8N71_RS22075	COG0594	ribonuclease P activity